WorldWideScience
1

Purification of mRNA guanylyltransferase from calf thymus.  

UK PubMed Central (United Kingdom)

mRNA guanylyltransferase has been extensively purified from calf thymus. A GTP-binding assay was used based on the observations by Shuman and Hurwitz (1981) and Venkatesan and Moss (1982) that vaccinia...Full Text Available

1982-01-01

2

No Effect of a Homeopathic Preparation on Neonatal Calf Diarrhoea in a Randomised Double-Blind, Placebo-Controlled Clinical Trial  

UK PubMed Central (United Kingdom)

A double-blind, placebo-controlled clinical trial of a homeopathic treatment of neonatal calf diarrhoea was performed using 44 calves in 12 dairy herds. Calves with spontaneously derived diarrhoea were...Full Text Available

2003-01-01

3

Timber Compartment Boundary  

Science.gov (United States)

Timber Compartment Boundary This data set identifies the 90 timber compartment boundaries in a 200 square-mile study ... Kawishiwi Ranger Districts, Superior National ...

4

In vivo phosphorylation of histones H1 and H5 in calf thymus and chicken erythrocytes as studied by /sup 31/P nuclear magnetic resonance spectroscopy  

Energy Technology Data Exchange (ETDEWEB)

The /sup 31/P NMR method was first applied to characterize in vivo phosphorylation of H1 and H5 in calf thymus and chicken erythrocytes as well as in vitro phosphorylation of H1 and H5 by cAMP-dependent protein kinase. The amino acid residues phosphorylated in vivo in the histones were exclusively serine residues, and the mole fraction of phosphoserine was estimated to be 0.34 and 0.27 per molecule of calf thymus H1 and chicken erythrocyte H5, respectively. Interestingly, chicken erythrocyte H1 was not phosphorylated in vivo. Three H1 subtypes from calf thymus H1 varied in the /sup 31/P NMR spectra, and the bisected fragments of calf thymus H1 and chicken erythrocyte H5 exhibited characteristic spectral patterns, indicating that there are considerable diversities of the degree of phosphorylation and phosphorylation sites in very-lysine-rich histones. Furthermore, it was found that the microenvironment ...

1987-08-01

5

Duodenal ileus caused by a calf feeding nipple in a cow  

UK PubMed Central (United Kingdom)

BackgroundThe aim of this report was to describe duodenal obstruction caused by a rubber foreign body in a cow.Case PresentationThe clinical, biochemical...Full Text Available

7

Why is it getting more difficult to successfully artificially inseminate dairy cows?*  

UK PubMed Central (United Kingdom)

Successfully using artificial insemination (AI) is defined as getting cows pregnant when the farmer wants them in-calf and making the best use of appropriate genetic potential. Over the past...Full Text Available

2008-08-01

8

Changes in Tetracycline Susceptibility of Enteric Bacteria following Switching to Nonmedicated Milk Replacer for Dairy Calves?  

UK PubMed Central (United Kingdom)

A randomized intervention study was conducted to determine if discontinuing use of calf milk replacer medicated with oxytetracycline results in increased tetracycline susceptibility in Salmonella...Full Text Available

2008-06-01

12

Effects of chronic ingestion of tritiated water on prenatal brain development  

International Nuclear Information System (INIS)

In view of the anticipated increased use of atomic energy in industry, the possible long-term effects of chronic radiation exposure were studied in five generations of rats. Female rats (F_0) were given tritiated drinking water ("3HOH;3#mu#Ci/ml) from adolescence (60 days) until and throughout pregnancy. A separate study showed that the maximum radioactivity in the urine is reached in 30 days, and in the blood in 42 days. In the newborns, the highest specific activity was in the nucleic acid fraction, but total radioactivity was mainly due to the water (body fluids) compartment. No signs of radiation illness or increase in cataract formation in the mothers were observed. The food and water intake and body weight changes before pregnancy were normal. The course and the outcome of pregnancy were also normal. However, 60% of the newborns (F_1) exhibited hematomas, edemas, and subdural hemorrhages, which disappeared at 30 days of age. Bollod ...

14

Handbook: Approaches for the Remediation of Federal Facility ...  

Science.gov (United States)

... 4-4 UXO disposal operations ... testing of sequencing batch reactor treatment of ... and lead toward the anode compartment ..... ...

1993-09-01

15

CARBON DIOXIDE REDUCTION SYSTEM  

Science.gov (United States)

... be easily replaceable, and its compartment or container ... in a simple, efficient manner for storage or disposal. ... and enters the reactor at approximatel ...

1963-01-01

16

Device for laying cut peat in a drying formation  

Energy Technology Data Exchange (ETDEWEB)

A device for laying cut peat in drying formations is proposed consisting of separate compartments, reinforced on a common frame and with mechanisms for both vertical and horizontal mixing. In order to intensify the drying process, within the scope of laying cut peat, uniform clearances and spacing in formations is applied. The mixing compartments are joined in sections with capabilities for separate mixing in each unit. The compartments are joined together by hinges and can be turned 180 degrees on the hinges horizontal to the plane.

1980-06-17

21

Evaluation of Systemic Markers Related To Anemia of Chronic Disease in the Peripheral Blood of Smokers and Non-Smokers with Chronic Periodontitis  

UK PubMed Central (United Kingdom)

ObjectivesThe aim of this study was to investigate the effect of cigarette smoking on clinical parameters and signs anemia of chronic disease in chronic periodontitis patients.Full Text Available

2008-04-01

23

Chronic Fatigue: Can Natural Remedies Boost My Energy?  

Science.gov (United States)

... Question Chronic fatigue: Can natural remedies boost my energy? Are there any natural remedies that reduce chronic ... AN01764 ">Chronic fatigue: Can natural remedies boost my energy? Guidelines for sites linking to MayoClinic.com ...

25

Advances in Chronic Kidney Disease - Elsevier  

Wastenet

...Advances in Chronic Kidney Disease-The purpose of Advances Chronic Kidney Disease is to provide in-depth, scholarly review articles about the care and mana ... Advances in Chronic Kidney Disease - Elsevier Home Products User Resources About Us Support & Contact Elsevier Websites Advanced Product ...Search Browse Journals Advances in Chronic Kidney Disease Advances in Chronic Kidney Disease Additional Information Related Publications Editorial Board Journal Online e- Alert Readers ...year: 6 Tips Title This is my tip content Visit Advances in Chronic Kidney Disease Online! The purpose of Advances Chronic Kidney Disease is ...

26

Category III Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Insights from The National Institutes of Health Chronic Prostatitis Collaborative Research Network Studies  

UK PubMed Central (United Kingdom)

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) remains an enigmatic medical condition. Creation of the (NIH) Chronic Prostatitis Collaborative Research Network (CPCRN) funded by...Full Text Available

2008-07-01

27

The DNA and RNA specificity of eilatin Ru(II) complexes as compared to eilatin and ethidium bromide  

UK PubMed Central (United Kingdom)

Eilatin-containing ruthenium complexes bind to a broad range of different nucleic acids including: calf thymus (CT) DNA, tRNAPhe, polymeric RNAs and DNAs, and viral RNAs including the HIV-1...Full Text Available

2003-10-01

28

Transurethral Ultrasound Diffraction Tomography  

Science.gov (United States)

... [5] GT Gullberg, RH Huesman, DNG Roy, J. Qi and BW Reutter, Esti- mation of the parameter covariance matrix for a one-compartment cardiac ...

2007-03-01

29

The mammalian oocyte orchestrates the rate of ovarian follicular development  

UK PubMed Central (United Kingdom)

The development of both the mammalian oocyte and the somatic cell compartments of the ovarian follicle is highly coordinated; this coordination ensures that the ovulated oocyte is ready to undergo fertilization...Full Text Available

2002-03-05

30

Navy Nuclear-Powered Surface Ships: Background, Issues ...  

Science.gov (United States)

... and support cost, and post-retirement disposal cost) of ... from reactors, and the reactors and other ... the ship's hull and reactor compartment enough to ...

2010-06-10

31

Correlation between particle size, in vivo particle persistence, and lung injury.  

UK PubMed Central (United Kingdom)

Dosimetry parameters such as deposition, clearance, retention, and translocation and dissolution of inhaled particles in and to different lung compartments may be important for the persistence of particles...Full Text Available

1994-10-01

32

Carbohydrate-specified endocytosis: localization of ligand in the lysosomal compartment.  

UK PubMed Central (United Kingdom)

Carbohydrate-directed endocytosis is mediated by a receptor, the hepatic binding protein; it is responsible for the clearance of galactose-terminated glycoproteins from the circulation. This process...Full Text Available

1981-11-01

33

Adder bite: an uncommon cause of compartment syndrome in northern hemisphere  

UK PubMed Central (United Kingdom)

Snakebite envenomation is an uncommon condition in the northern hemisphere, but requires high vigilance with regard to both the systemic effects of the venom and the locoregional impact on the soft...Full Text Available

34

A comprehensive assessment of N-terminal signal peptides prediction methods  

UK PubMed Central (United Kingdom)

BackgroundAmino-terminal signal peptides (SPs) are short regions that guide the targeting of secretory proteins to the correct subcellular compartments in the cell. They are cleaved...Full Text Available

35

Tissue Localization of Australia Antigen Immune Complexes in Acute and Chronic Hepatitis and Liver Cirrhosis  

UK PubMed Central (United Kingdom)

In a significant percentage of examined cases of fulminant hepatitis, subacute hepatitis, chronic aggressive hepatitis, liver cirrhosis and chronic persistent hepatitis, Australia (hepatitis-associated)...Full Text Available

1972-07-01

36

Comparison between children and adolescents with and without chronic benign pain: consultation rate and pain characteristics.  

UK PubMed Central (United Kingdom)

The aim of the study was to determine whether children with chronic benign pain are in contact with their general practitioner (GP) more frequently than those without chronic benign pain. A random sample...Full Text Available

2002-03-01

37

Role of spinal cyclooxygenase in human postoperative and chronic pain  

UK PubMed Central (United Kingdom)

BackgroundNonsteroidal anti-inflammatory drugs are commonly used to treat postoperative and chronic pain. Animal studies suggest these drugs act in part by blocking...Full Text Available

2010-05-01

38

Evaluation of the microbiology of chronic ethmoid sinusitis.  

UK PubMed Central (United Kingdom)

In a prospective study, patients with the diagnosis of chronic ethmoid sinusitis were evaluated microbiologically by using biopsy specimens of the ethmoid sinus mucosa. Microbiology cultures were performed...Full Text Available

1991-11-01

39

Chronic toxicity of environmental contaminants: sentinels and biomarkers.  

UK PubMed Central (United Kingdom)

Due to the use of a limited number of species and subchronic exposures, current ecological hazard assessment processes can underestimate the chronic toxicity of environmental contaminants resulting...Full Text Available

1997-02-01

40

Chronic kidney disease in children: the global perspective  

UK PubMed Central (United Kingdom)

In contrast to the increasing availability of information pertaining to the care of children with chronic kidney disease (CKD) from large-scale observational and interventional studies, epidemiological...Full Text Available

2007-12-01

41

Identification of a nucleoside triphosphate binding site on calf thymus RNA polymerase II  

Energy Technology Data Exchange (ETDEWEB)

A nucleoside triphosphate binding site on calf thymus RNA polymerase II was identified by using photoaffinity analogues of adenosine 5'-triphosphate and guanosine 5'-triphosphate. Both radiolabeled 8-azidoadenosine 5'-triphosphate (8-N3ATP) and radiolabeled 8-azidoguanosine 5'-triphosphate (8-N3GTP) bound to a single polypeptide of this enzyme. This polypeptide has a molecular mass of 37 kilodaltons and an isoelectric point of 5.4. Ultraviolet (UV) irradiation was necessary for photolabeling to occur. In addition, no labeling occurred when the probe was prephotolyzed or when the enzyme was inactivated. Furthermore, photolabeling of the enzyme could be decreased by preincubation with natural substrates. To provide evidence that the radiolabeled polypeptide forms a part of the domain of the nucleoside triphosphate binding site, experiments were performed using unlabeled 8-N3ATP. Although this unlabeled analogue was not a substrate ...

1986-01-14

42

Development of a generic analysis code of dynamic compartment model for evaluation of doses in terrestrial biosphere  

International Nuclear Information System (INIS)

The release rate of a nuclide from a reactor or a radioactive waste disposal plant at the accident is not steady, but varies with time. The various parameters of a nuclide migration into environment vary also day after day, or with the seasons. In such cases, dynamic behavior of the nuclide in the environment must be taken into consideration. It is difficult for a mathematical model to involve all of mechanisms for the nuclide migration. The environment for evaluation of doses are usually divided into some of compartments in which a nuclide concentration is uniform. Time variations of the nuclide concentration in the compartment are described in simultaneous differential equations. The nuclide concentration can be solved as a time function, and the radiation doses, therefore, can be estimated as a time function. Generic analysis code for dynamic compartment model (GACOM) is developed for the nuclide migration and the ...

1999-02-01

48

PRODUCT NAME BARITE  

Wastenet

the low levels of crystalline silica in this product, chronic health effects are not anticipated with normal

52

Long-term storage facility for reactor compartments in Sayda Bay - German support for utilization of nuclear submarines in Russia  

Science.gov (United States)

The German-Russian project that is part of the G8 initiative on Global Partnership Against the Spread of Weapons and Materials of Mass Destruction focuses on the speedy construction of a land-based interim storage facility for nuclear submarine reactor compartments at Sayda Bay near Murmansk. This project includes the required infrastructure facilities for long-term storage of about 150 reactor compartments for a period of about 70 years. The interim storage facility is a precondition for effective activities of decommissioning and dismantlement of almost all nuclear-powered submarines of the Russian Northern Fleet. The project also includes the establishment of a computer-assisted waste monitoring system. In addition, the project involves clearing Sayda Bay of other shipwrecks of the Russian navy. On the German side the project is carried out by the Energiewerke Nord GmbH (EWN) on behalf of the Federal Ministry of Economics and Labour (BMWi). ...

2007-07-01

53

Depression and chronic fatigue in the patient with chronic pain.  

Science.gov (United States)

Chronic benign pain is commonly associated with chronic fatigue and depression. Depression and chronic fatigue syndrome are also associated with each other and often include pain. Psychologic factors are prominent in these conditions, and they may share neurobiologic factors as well. Management requires separately addressing each component of patients' distress and usually includes physical rehabilitation, education, administration of nonhabituating medications and often counseling. Depression may be a favorable prognostic sign, as it suggests a treatable condition and provides incentive for recovery. PMID:1876618

1991-06-01

54

Simulation on energy use for mechanical ventilation and air-conditioning (MVAC) systems in train compartments  

Energy Technology Data Exchange (ETDEWEB)

Unlike the conventional automotive, modem railway trains are designed with non-openable windows; and a mechanical ventilation and air-conditioning (MVAC) system is installed in each train compartment for better indoor air quality as well as to provide a thermally comfortable environment. The ventilation rate is no doubt a critical element in the design of a MVAC system, especially in Hong Kong where the daily passenger load is extremely heavy. Earlier studies illustrated that carbon dioxide can be controlled at 1000 ppm by increasing the ventilation rate to 25.2 m{sup 3} h{sup -1}; however, it will also lead to an increase in energy consumption. In this paper, the electrical energy consumption at various ventilation rates was studied, and the cost of maintaining a low carbon dioxide level was estimated These provide solid information for the local railway companies to improve the air quality inside the train compartments. (author)

2000-01-01

55

Microanalytical method development for Fe, Cu and Zn determination in colorectal cancer cells  

British Library Electronic Table of Contents (United Kingdom)

Microanalytical methods suitable for the determination of Fe, Cu in HT-29 (human colon adenocarcinoma) cells treated with different iron compounds (Fe(II) sulfate, Fe(III) chloride, Fe(III) citrate and Fe(III) transferrin) and cultured in medium supplemented or not with 10% (v/v) fetal calf serum (FCS) by total reflection X-ray fluorescence spectrometry (TXRF) and simultaneous graphite furnace atomic absorption spectrometry (GF-AAS) were developed. The developed TXRF method was also suitable for Zn determination in the samples. The main advantage of the proposed methods is the execution of all sample preparation steps following incubation and prior to the elemental analysis in the same Eppendorf tubes. Sample preparation was performed at microscale (115mL sample volume) with 65% nitric aci...

2011-01-01

56

In vitro diffusion bed, 3-day repeat challenge `capacity' test for antimicrobial wound dressings:  

British Library Electronic Table of Contents (United Kingdom)

Greenman J, Thorn RMS, Saad S, Austin AJ. In vitro diffusion bed, 3-day repeat challenge `capacity' test for antimicrobial wound dressings. Int Wound J 2006;3:322-329. Abstract The aim of this study was to develop an in vitro wound infection model that allows the comparison of the bacterial kill rate of antimicrobial wound dressings over the course of 3 days, with renewed microbial challenges each day, under realistic wound-like conditions. A test bed model of a moderately exuding wound was constructed from a hydrogel containing releasable foetal calf serum (FCS), and cellulose discs dosed with test microbes (Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa) suspended in 50% FCS applied at the interface between the test dressing and the hydrogel test bed. Freshly prep...

2006-01-01

57

Curcumin Binding to DNA and RNA  

British Library Electronic Table of Contents (United Kingdom)

Curcumin, the yellow pigment from the rhizoma of Curcuma longa, is a widely studied phytochemical with a variety of biological activities. The ongoing research and clinical trials have proved that this natural phenolic compound has great and diverse pharmacological potencies. Beside its effective antioxidant, antiinflammatory, and antimicrobial/antiviral properties, curcumin is also considered as a cancer chemopreventive agent. While the antioxidant activity of curcumin is well documented, its interaction with DNA and RNA is not fully investigated. This study was designed to examine the interactions of curcumin with calf thymus DNA and yeast RNA in aqueous solution at physiological conditions, using constant DNA and RNA concentration (6.25?mM) and various curcumin/polynucleotide (phosphate...

2009-01-01

58

A calf for all seasons? The potential of stable isotope analysis to investigate prehistoric husbandry practices  

British Library Electronic Table of Contents (United Kingdom)

The Early Bronze Age barrows at Irthlingborough and Gayhurst in central England are notable for the large number of cattle (Bos taurus) remains associated with their human Beaker burials. Previous work using strontium isotope analysis has indicated that most of the cattle analysed, and one aurochs (Bos primigenius), were of local origin [Towers, J., Montgomery, J., Evans, J., Jay, M., Parker Pearson, M., 2010. An investigation of the origins of cattle and aurochs deposited in the Early Bronze Age barrows at Gayhurst and Irthlingborough. Journal of Archaeological Science 37, 508-515.]. In this study, stable isotope analysis of enamel and bone was carried out to investigate whether the mature cattle had experienced similar husbandry practices, climate and environment. Bulk carbon, nitrogen a...

2011-01-01

59

Total Antioxidant Performance Is Associated with Diet and Serum Antioxidants in Participants of the Diet and Physical Activity Substudy of the Jackson Heart Study12  

UK PubMed Central (United Kingdom)

Total antioxidant performance (TAP) measures antioxidant capacities in both hydrophilic and lipophilic compartments of serum and interactions known to exist between them. Our objective was to assess...Full Text Available

2009-10-01

60

STS-94 - Johnson Space Center - NASA  

Science.gov (United States)

spacecraft and aircraft propulsion, and hazardous waste disposal. .... called lockers and two larger, standardized compartments called drawers. ..... ductile refractory metal used chiefly in nuclear reactors and chemical processing ...

61

STS-83 - Johnson Space Center - NASA  

Science.gov (United States)

Radiation Measurement in Crew Compartment. DTO 805: .... spacecraft and aircraft propulsion, and hazardous waste disposal. ...... combustion reactions in a turbulent chemical kinetic flow reactor using laser induced fluorescence and ...

62

Regulation of basal cellular physiology by the homeostatic unfolded protein response  

UK PubMed Central (United Kingdom)

The extensive membrane network of the endoplasmic reticulum (ER) is physically juxtaposed to and functionally entwined with essentially all other cellular compartments. Therefore, the ER must sense...Full Text Available

2010-05-31

63

PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast  

UK PubMed Central (United Kingdom)

Eukaryotic cells can massively transport their own cytoplasmic contents into a lytic compartment, the vacuole/lysosome, for recycling through a conserved system called autophagy. The key process in...Full Text Available

2011-01-01

64

International Space Station Overview - NASA  

Science.gov (United States)

(accumulates & stores brine for disposal). Separator. (separates water from purge gases). ? Purge pump periodically vent ... Reactor Health. Sensor. ( verifies reactor is operating w/n limits) ... Waste and Hygiene Compartment ...

65

Heat Stress Enhances the Accumulation of Polyadenylated Mitochondrial Transcripts in Arabidopsis thaliana  

UK PubMed Central (United Kingdom)

BackgroundPolyadenylation of RNA has a decisive influence on RNA stability. Depending on the organisms or subcellular compartment, it either enhances transcript stability or targets...Full Text Available

66

Asynchronous Cell Cycle and Asymmetric Vacuolar Inheritance in True Hyphae of Candida albicans  

UK PubMed Central (United Kingdom)

Candida albicans forms unconstricted hyphae in serum-containing medium that are divided into discrete compartments. Time-lapse photomicroscopy, flow cytometry, and a novel three-dimensional...Full Text Available

2003-06-01

67

Activity-Dependent Augmentation of Spontaneous Neurotransmission during Endoplasmic Reticulum Stress  

UK PubMed Central (United Kingdom)

The endoplasmic reticulum (ER) is an essential cellular compartment responsible for Ca2+ sequestration, signaling, protein translation, folding as well as transport. Several acute...Full Text Available

2010-05-26

68

A marine compartment model for collective dose assessment of liquid radioactive effluents  

International Nuclear Information System (INIS)

A compartment model is described which is currently used by the Ministry of Agriculture, Fisheries and Food to calculate collective radiation exposure due to liquid radioactive wastes discharged to sea from UK nuclear sites. Collective dose is a useful indicator of the radiological impact of a disposal practice and is one of the quantities needed to show compliance with the ICRP system of dose limitation. The model has been used for the purposes of the Sizewell Inquiry to predict the collective radiation exposure from reactor operation at Sizewell and, on the basis of current Sellafield experience, correlations between dose and discharge for disposals of fuel reprocessing wastes. (author).

1982-01-01

69

Basic aspects of the concept of reactor compartment (including damaged compartments) management during utilization of nuclear powered submarines -- High priority R and D  

International Nuclear Information System (INIS)

Large-scale decommissioning of Russian nuclear-powered submarines (NPS) and their utilization prospects gave rise to numerous complicated scientific and technical, as well as economic, problems. Problems of handling of radioactive equipment from the reactor compartments (RC) are among the vital ones, arousing a growing concern with the public. Without solution of the problems the processes of NPS utilization can not be considered completed. It involves potential hazard, for the environment both from NPS being paid up (temporal on-float storage) with unloaded spent nuclear fuel (SNF), and RC, cut from submarine hull, containing highly radioactive equipment and materials but no SNF. Diverse variations of the concept of reactor compartment handling of NPS subject to, utilization are possible, but, in principle, there are essentially two variants: (1) RC utilization directly in the course of NPS utilization, envisaging removal of radioactive ...

1996-03-10

70

Use of complementary and alternative medicines for children with chronic health conditions in Lagos, Nigeria  

UK PubMed Central (United Kingdom)

BackgroundThe use of complementary and alternative medicine (CAM) is on the increase globally with a high prevalence in children and adults with chronic illnesses. Many studies have...Full Text Available

71

Trends in use of opioids for chronic non-cancer pain among individuals with mental health and substance use disorders: the TROUP study  

UK PubMed Central (United Kingdom)

ObjectivesUse of prescription opioids for chronic pain is increasing, as is abuse of these medications, though the nature of the link between these trends is unclear....Full Text Available

2010-01-01

72

Therapeutic Vaccination in Chronic Hepatitis B: Preclinical Studies in the Woodchuck  

UK PubMed Central (United Kingdom)

Recommended treatment of chronic hepatitis B with interferon-α and/or nucleos(t)ide analogues does not lead to a satisfactory result. Induction of HBV-specific T cells by therapeutic...Full Text Available

2010-01-01

73

The management of children with chronic fatigue syndrome-like illness in primary care: a cross-sectional study  

UK PubMed Central (United Kingdom)

BackgroundMost studies on children with chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) have been undertaken in tertiary care and little is known about their management...Full Text Available

2006-01-01

74

The costs of hospitalization in patients with acute exacerbation of chronic obstructive pulmonary disease  

UK PubMed Central (United Kingdom)

Introduction:Chronic obstructive pulmonary disease (COPD) is a major public health problem. It imparts a substantial economic burden on individuals and society. Acute exacerbations...Full Text Available

75

Substance Misuse Treatment for High Risk Chronic Pain Patients on Opioid Therapy: A Randomized Trial  

UK PubMed Central (United Kingdom)

Chronic pain patients who show aberrant drug-related behavior often are discontinued from treatment when they are noncompliant with their use of opioids for pain. The purpose of this study was...Full Text Available

2010-09-01

76

Spinal Cord Stimulation for Intractable Visceral Pain due to Chronic Pancreatitis  

UK PubMed Central (United Kingdom)

Pain caused by chronic pancreatitis is medically intractable and resistant to conventional interventional or surgical treatment. We report a case of spinal cord stimulation (SCS) for intractable pain...Full Text Available

2009-08-01

77

Sociodemographic factors in a pediatric chronic pain clinic: The roles of age, sex and minority status in pain and health characteristics  

UK PubMed Central (United Kingdom)

Little is known about how sociodemographic factors relate to children’s chronic pain. This paper describes the pain, health, and sociodemographic characteristics of a cohort of children...Full Text Available

2010-07-01

78

Sleep and Fatigue Symptoms in Children and Adolescents With CKD: A Cross-sectional Analysis From the Chronic Kidney Disease in Children (CKiD) Study  

UK PubMed Central (United Kingdom)

BackgroundAlthough symptoms of sleepiness and fatigue are common among adults with Chronic Kidney Disease (CKD), little is known about the prevalence of these symptoms...Full Text Available

2010-02-01

79

Severely disabling chronic pain in young adults: prevalence from a population-based postal survey in North Staffordshire  

UK PubMed Central (United Kingdom)

BackgroundSeverely disabling chronic pain in the adult population is strongly associated with a range of negative health consequences for individuals and high health care costs,...Full Text Available

80

Randomised trial of telephone intervention in chronic heart failure: DIAL trial  

UK PubMed Central (United Kingdom)

Objective To determine whether a centralised telephone intervention reduces the incidence of death or admission for worsening heart failure in outpatients with chronic heart failure.Design...Full Text Available

2005-08-20

81

Pulmonary Function and the Risk of Functional Limitation in Chronic Obstructive Pulmonary Disease  

UK PubMed Central (United Kingdom)

The authors’ objective was to analyze the impact of respiratory impairment on the risk of physical functional limitations among adults with chronic obstructive pulmonary disease (COPD)....Full Text Available

2008-05-01

82

Propranolol ameliorates the development of portal-systemic shunting in a chronic murine schistosomiasis model of portal hypertension.  

UK PubMed Central (United Kingdom)

We investigated the role of early portal hypotensive pharmacotherapy in preventing the development of portal-systemic shunting in a portal hypertensive model of chronic murine schistosomiasis induced...Full Text Available

1991-03-01

83

Prevalence of Ocular Fundus Pathology in Patients with Chronic Kidney Disease  

UK PubMed Central (United Kingdom)

Background and objectives: The objective of this study was to describe the prevalence of ocular fundus pathology in the Chronic Renal Insufficiency Cohort (CRIC) study, a multicenter, longitudinal study...Full Text Available

2010-05-01

84

Physical Activity and Mortality in Chronic Kidney Disease (NHANES III)  

UK PubMed Central (United Kingdom)

Background and objectives: Chronic kidney disease (CKD) is associated with impaired physical activity. However, it is unclear whether the associations of physical activity with mortality are modified...Full Text Available

2009-12-01

85

Patient-Care Practices Associated With an Increased Prevalence Of Hepatitis C Virus Infection among Chronic Hemodialysis Patients  

UK PubMed Central (United Kingdom)

ObjectiveTo identify patient-care practices related to an increased prevalence of hepatitis C virus (HCV) infection among chronic hemodialysis patients.Full Text Available

2011-05-01

86

Opioids and the Treatment of Chronic Pain: Controversies, Current Status, and Future Directions  

UK PubMed Central (United Kingdom)

Opioids have been regarded for millennia as among the most effective drugs for the treatment of pain. Their use in the management of acute severe pain and chronic pain related to advanced medical...Full Text Available

2008-10-01

87

Living and dying with severe chronic obstructive pulmonary disease: multi-perspective longitudinal qualitative study  

UK PubMed Central (United Kingdom)

Objectives To understand the perspectives of people with severe chronic obstructive pulmonary disease (COPD) as their illness progresses, and of their informal and professional carers,...Full Text Available

2011-01-01

88

Legionella lansingensis sp. nov. isolated from a patient with pneumonia and underlying chronic lymphocytic leukemia.  

UK PubMed Central (United Kingdom)

A Legionella-like organism, strain 1677-MI-H, was isolated from the bronchoscopy washings of a patient with pneumonia who had a 2-year history of progressive, chronic lymphocytic leukemia. The growth...Full Text Available

1992-09-01

89

High-Speed Ultrahigh-Resolution Optical Coherence Tomography Findings in Chronic Solar Retinopathy  

UK PubMed Central (United Kingdom)

PurposeTo describe ocular findings for a 34-year-old man with chronic solar retinopathy using high-speed ultrahigh-resolution (UHR) optical coherence tomography (OCT).Full Text Available

2008-01-01

90

Helicobacter pylori infection, oncogenic pathways and epigenetic mechanisms in gastric carcinogenesis  

UK PubMed Central (United Kingdom)

Chronic colonization of the human stomach by Helicobacter pylori, a Gram-negative bacterium, is the major cause of chronic gastritis, peptic ulcers and gastric cancer. Recent...Full Text Available

2010-05-01

91

Exploring the impact of a decision support intervention on vascular access decisions in chronic hemodialysis patients: study protocol  

UK PubMed Central (United Kingdom)

BackgroundIn patients with Stage 5 Chronic Kidney Disease who require renal replacement therapy a major decision concerns modality choice. However, many patients defer the decision...Full Text Available

92

Evaluating Patients with Chronic Pain and their Families  

UK PubMed Central (United Kingdom)

Inclusion of family members in the assessment of patients with chronic pain can improve outcomes. Family functioning can be assessed in four basic areas: boundaries, power, communication, and intimacy....Full Text Available

1991-02-01

93

Efficacy and cost-effectiveness of a physiotherapy program for chronic rotator cuff pathology: A protocol for a randomised, double-blind, placebo-controlled trial  

UK PubMed Central (United Kingdom)

BackgroundChronic rotator cuff pathology (CRCP) is a common shoulder condition causing pain and disability. Physiotherapy is often the first line of management for CRCP yet there...Full Text Available

94

Determination of risk factors for hepatitis B and C in male patients suffering from chronic hepatitis  

UK PubMed Central (United Kingdom)

BackgroundHepatitis B and C is common in Pakistan and various risk factors are attributable to its spread.One thousand and fifty consecutive male cases suffering from chronic...Full Text Available

95

Detecting Retroviral Sequences in Chronic Fatigue Syndrome  

UK PubMed Central (United Kingdom)

XMRV or xenotropic murine leukemia virus-related retrovirus, a recently discovered retrovirus, has been linked to both prostate cancer and chronic fatigue syndrome (CFS). Recently, the teams of Drs....Full Text Available

96

Chronic pain in primary care. German figures from 1991 and 2006  

UK PubMed Central (United Kingdom)

BackgroundUntil now only limited research has been done on the prevalence of chronic pain in primary care. The aim of this investigation was to study the health care utilisation...Full Text Available

97

Chronic or Recurrent Pain in the Emergency Department: National Telephone Survey of Patient Experience  

UK PubMed Central (United Kingdom)

ObjectivePersons with chronic or recurrent pain frequently visit the emergency department (ED), yet little research examines this experience. We conducted this national survey to...Full Text Available

2010-12-01

98

Chronic lymphatic leukaemia and engine exhausts, fresh wood, and DDT: a case-referent study.  

UK PubMed Central (United Kingdom)

The effect of potential risk factors for chronic lymphatic leukaemia was evaluated in a case-referent study encompassing 111 cases and 431 randomised referents, all alive. Information on exposure was...Full Text Available

1988-01-01

99

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas  

UK PubMed Central (United Kingdom)

Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs)....Full Text Available

2009-08-01

100

Chronic Wasting Disease Prions in Elk Antler Velvet  

UK PubMed Central (United Kingdom)

Chronic wasting disease (CWD) is a contagious, fatal prion disease of deer and elk that continues to emerge in new locations. To explore the means by which prions are transmitted with high efficiency...Full Text Available

2009-05-01

101

Characteristics of chronic non-specific musculoskeletal pain in children and adolescents attending a rheumatology outpatients clinic: a cross-sectional study  

UK PubMed Central (United Kingdom)

BackgroundChronic non-specific musculoskeletal pain (CNSMSP) may develop in childhood and adolescence, leading to disability and reduced quality of life that continues into adulthood....Full Text Available

102

Assessment and management of patients with chronic cough by Certified Respiratory Educators: A randomized controlled trial  

UK PubMed Central (United Kingdom)

BACKGROUND:The value of other health care professionals is increasingly being recognized to compensate for the shortage of physicians in Canada. Chronic cough is one of the most...Full Text Available

2009-02-01

103

Anti-albumin antibodies in chronic liver diseases: diagnostic significance of these antibodies in patients with conventional or immunosuppressive therapy.  

UK PubMed Central (United Kingdom)

The two categories of anti-albumin antibodies (AAA), namely precipitins (AA-P) and agglutinins (AA-Aggl), were investigated in 260 patients with morphologically diagnosed chronic liver diseases (CLD)....Full Text Available

1981-02-01

104

An Update on the Controversies in Anemia Management in Chronic Kidney Disease: Lessons Learned and Lost  

UK PubMed Central (United Kingdom)

Background. Erythropoietin deficiency and anemia occur in Chronic Kidney Disease (CKD) and may be treated with Erythropoietin Stimulating Agents (ESAs). The optimal hemoglobin,...Full Text Available

2011-01-01

105

An Analysis of Heavy Utilizers of Opioids for Chronic Non-Cancer Pain in the TROUP Study  

UK PubMed Central (United Kingdom)

ContextWhile opioids are increasingly used for chronic non-cancer pain (CNCP), we know little about opioid dosing patterns among individuals with CNCP in usual care...Full Text Available

2010-08-01

106

Advanced MRI Methods for Assessment of Chronic Liver Disease  

UK PubMed Central (United Kingdom)

MRI plays an increasingly important role for assessment of patients with chronic liver disease. MRI has numerous advantages, including lack of ionizing radiation and the possibility of performing...Full Text Available

2009-07-01

107

A predictive model of Health Related Quality of life of parents of chronically ill children: the importance of care-dependency of their child and their support system  

UK PubMed Central (United Kingdom)

BackgroundParents of chronically ill children are at risk for a lower Health Related Quality of Life (HRQoL). Insight in the dynamics of factors influencing parental HRQoL is necessary...Full Text Available

108

A non-selective (amitriptyline), but not a selective (citalopram), serotonin reuptake inhibitor is effective in the prophylactic treatment of chronic tension-type headache.  

UK PubMed Central (United Kingdom)

OBJECTIVES: Although the tricyclic antidepressant amitriptyline is extensively used in the prophylactic treatment of chronic tension-type headache, only few studies have investigated the efficacy of...Full Text Available

1996-09-01

109

A System for Evaluating and Treating Chronic Back Disability  

UK PubMed Central (United Kingdom)

Five methods of personality assessment are evaluated to provide guidance for the psychological treatment of patients with chronic back pain. Patient pain drawings, pentothal pain studies, stress score...Full Text Available

1976-05-01

111

PRODUCT NAME CAUSTIC SODA (RHEOCHEM)  

Wastenet

has the potential to cause severe acute and chronic health effects with over exposure.Use safe work

112

Healthy Nutrition: Breastfeeding  

Medline Plus

... Dynamics Media Work & Play Health Issues Conditions Abdominal ADHD Allergies & Asthma Chest & Lungs Chronic Conditions Developmental Disabilities ...

113

Xenotropic murine leukaemia virus-related virus (XMRV) does not cause chronic fatigue.  

Science.gov (United States)

The xenotropic murine leukaemia virus-related virus (XMRV), a gammaretrovirus, was discovered in prostate cancer tumours by Virochip technology in 2006. It was subsequently detected in chronic fatigue patients in 2009. The association between XMRV and chronic fatigue has proved to be controversial. No study has confirmed these findings and many have refuted them. Here, we present the evidence for our contention that XMRV is not a human pathogen. PMID:21978843

2011-10-01

114

The Impact of Proactive Chronic Care Management on Hospital Admissions in a German Senior Population  

British Library Electronic Table of Contents (United Kingdom)

Abstract An increase in chronic disease prevalence is contributing to health care cost growth and decreased quality of life in industrialized nations worldwide. Inadequate management of chronic diseases is a leading cause of hospitalizations and, thus, avoidable expenditures. In this study, we evaluated the impact of nurse-delivered care calls, the primary intervention of a proactive chronic care management (CCM) program, in a population aged 65 and older in Germany. In this analysis, hospital admission rates were evaluated among program enrollees who were diagnosed with diabetes, heart failure, coronary heart disease, or chronic obstructive pulmonary disease. The Intervention group comprised those members who participated in care calls (n?=?13,486), whereas the Comparison group included e...

2011-01-01

115

Physical therapy for chronic pain conditions—A novel approach using mind–body connection  

British Library Electronic Table of Contents (United Kingdom)

The treatment of chronic pain conditions continue to present a challenge to the medical field. Physical therapy treatment needs to approach the management of chronic pain differently than the approach used to resolve acute pain. Patients with chronic pain often have many factors that have perpetuated the pain condition. These factors, as well as pain itself, influence their ability to reactivate and perform functional daily activities. Physical therapists can begin to address some of the factors, including fear and deconditioning, by building confidence and body awareness in a self-care model including a slow graduated reactivation program. There is evidence that patients with chronic pain conditions have altered motor control that may be influencing reoccurrences and possible flares of pa...

2011-01-01

116

Effects of Scutellaria baicalensis on chronic cerebral hypoperfusion-induced memory impairments and chronic lipopolysaccharide infusion-induced memory impairments  

British Library Electronic Table of Contents (United Kingdom)

Ethnopharmacological relevance: Extracts of the roots of Scutellaria baicalensis Georgi (Labiatae) have been widely used to relieve fever related to bacterial infection and inflammatory diseases in traditional Korean medicine and have been reported to be effective in brain diseases. These experiments were conducted to examine the effects of oral administration of Scutellaria baicalensis extracts on the rescue of memory impairments induced by chronic cerebral hypoperfusion or chronic lipopolysaccharide (LPS) infusion. In addition, the underlying mechanisms of these effects were investigated. Materials and methods: In the first experiment, chronic cerebral hypoperfusion was induced in male Wister rats by bilateral common carotid artery occlusion (BCCAo). Daily administration of Scutellaria b...

2011-01-01

117

Chronic and non-communicable diseases: a critical challenge for nurses globally  

British Library Electronic Table of Contents (United Kingdom)

ALLEYNE G., HANCOCK C. & HUGHES P. (2011) Chronic and non-communicable diseases: a critical challenge for nurses globally. International Nursing Review58, 328-331 Background:- Chronic and non-communicable diseases (NCDs) are a growing and enormous challenge that faces countries across the world. Low- and middle-income countries are disproportionately affected. Contributory factors:- Three risk factors - tobacco use, poor diet (including excessive alcohol intake) and lack of physical activity - contribute to four major chronic diseases - cardiovascular, chronic obstructive pulmonary disease, diabetes and some cancers, which are responsible for over 50% of deaths worldwide. Potential solutions:- International governmental and non-governmental agencies are becoming increasingly concerned and ...

2011-01-01

118

CFD investigation of balcony spill plumes in atria  

Energy Technology Data Exchange (ETDEWEB)

Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production rate of the buoyant fire plume. One design issue is the smoke production rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes are based on a combination of one-tenth scale test data and theoretical analysis. Questions have arisen over the suitability of these correlations for real-scale designs. A combined program of full-scale experimentation and CFD modeling is being conducted to analyze the accuracy of these correlations. A full-scale experimental facility was constructed with a 5 m by 5 m by 15 m fire compartment connected to a four-story atrium. Propane fires in the ...

2004-07-01

119

CFD investigation of balcony spill plumes in atria  

International Nuclear Information System (INIS)

Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production rate of the buoyant fire plume. One design issue is the smoke production rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes are based on a combination of one-tenth scale test data and theoretical analysis. Questions have arisen over the suitability of these correlations for real-scale designs. A combined program of full-scale experimentation and CFD modeling is being conducted to analyze the accuracy of these correlations. A full-scale experimental facility was constructed with a 5 m by 5 m by 15 m fire compartment connected to a four-story atrium. Propane fires in the ...

2004-05-09

120

Development of a microbiological ammonium to nitrate recycling bioreactor for space capsules  

International Nuclear Information System (INIS)

Since 1988, the Expertise group of Molecular and Cellular Biology (MCB) is an important partner in the development of the Micro-Ecological Life Support System Alternative (MELiSSA). The MELiSSA was designed to allow a small crew to survive on an Antarctic, lunar or Mars outpost, and is a joint research project currently fostered by the European Space Agency, ESA. The MELiSSA functions through a series of five interconnected compartments, of which four are microbial bioreactors and was engineered to degrade organic waste, regenerate the outpost's atmosphere and water, and provide the crew with an additional vegetarian diet. The bioreactor of the third compartment provides the edible cyanobacteria and plants of the fourth compartment with nitrate instead of ammonium as a source of nitrogen. The two bacteria responsible for the biological transformation of ammonium to nitrate (nitrification) are Nitrosomonas europaea and ...

2009-09-01

121

Radiation factors specifying safety in reactor compartments handling in the process of decommissioning nuclear-powered submarines  

International Nuclear Information System (INIS)

The main problems arising in decommissioning nuclear-powered submarines (NPS) relate to choosing a concept of handling reactor compartments followed by handling technology development. Reactor compartments (RC) are characterized with extremely space-saving or integral layout of large-size power equipment and systems, restricted access for dismantling, high radiation dose rates in a number of bays of RC. The above RC features pose a problem to find optimum option of RC utilization which on the one hand would be the most cost efficient, and the safest as possible on the other, i.e. dose commitments of personnel involved should be minimum, and effect on population and environment should be negligible. The main radiation factors specifying safety in RC handling at any decommissioning stage are as follows: (1) total radioactivity integrated in reactor facility (RF); (2) distribution of this radioactivity through RF equipment and structures; (3) ...

1996-03-10

122

AIDE: internal dosimetry software.  

Science.gov (United States)

AIDE (Activity and Internal Dose Estimates) is a software for calculating activities in compartments and committed doses due to occupational exposures, and for performing intake and dose estimates using bioassay data. It has been continuously developed and tested for more than 20 years. Its calculation core has been applied in several situations, like performing all dose estimates due to (137)Cs intakes, which occurred during the Goiania accident in 1987; performing quality assurance of the ICRP Task Group on Dose Calculations regarding calculations of activities in compartments and generation of dose coefficients for adults due to intakes by inhalation, ingestion and injection of several radionuclides; and producing the tables of activities in compartments and dose coefficients using the NCRP Wound Model for the NCRP report. It provides several capabilities like performing calculations using modified Human Respiratory ...

2008-03-12

123

A radionuclide analyzer of total sulfur in coal  

International Nuclear Information System (INIS)

The devised radionuclide analyzer for the determination of total sulfur in coal includes two radionuclide sources with different energies, which are accommodated in collimators fitted with adjustable diaphramgs. The sample compartment is located between the two sources. Moreover, an X-ray fluorescence standard can be slid into the sample compartment. A proportional detector for X-ray fluorescence and scattered gamma radiation is located off the sample compartment. The input of the proportional detector is interfaced to the output of a high-voltage supply, the output, to the information input of a control-and-evaluation unit. One of the control outputs of the control-and-evaluation unit is connected to the input of the sliding mechanism for the X-ray fluorescence standard. This arrangement enables automatic energy calibration of the analyzer. The analyzer can measure not only total sulfur in coal by radionuclide X-ray ...

1987-05-13

124

CFD investigation of balcony spill plumes in atria (part II)  

Energy Technology Data Exchange (ETDEWEB)

This paper proposes an integrated method for using experimental data and CFD modeling to develop engineering correlations for atrium smoke management. Part I focused on the experimental program and validation of a CFD model of the experimental facility. Part II describes the extension of this model to a parametric study of balcony spill plumes. Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production or mass flow rate of the buoyant fire plume. One design issue is the mass flow rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes (BSPs) are based on a combination of one-tenth scale test data and theoretical analysis. The suitability of these correlations ...

2005-07-01

125

CFD investigation of balcony spill plumes in atria (part II)  

International Nuclear Information System (INIS)

This paper proposes an integrated method for using experimental data and CFD modeling to develop engineering correlations for atrium smoke management. Part I focused on the experimental program and validation of a CFD model of the experimental facility. Part II describes the extension of this model to a parametric study of balcony spill plumes. Smoke management in buildings during fire events often uses mechanical ventilation systems to maintain smoke layer elevation above a safe evacuation path. Design of these systems requires accurate correlations for the smoke production or mass flow rate of the buoyant fire plume. One design issue is the mass flow rate of fire plumes which spill out from a fire compartment, under a balcony and up through an atrium or other large volume. Current engineering correlations for these balcony spill plumes (BSPs) are based on a combination of one-tenth scale test data and theoretical analysis. The suitability of these correlations ...

126

Selective downregulation of retinoic acid-inducible gene I within the intestinal epithelial compartment in crohn's disease  

British Library Electronic Table of Contents (United Kingdom)

AbstractBackground: A defective innate immune response may contribute to the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC). Employing a global gene expression analysis, this study was aimed at identifying specifically regulated genes within the epithelial compartment in inflammatory bowel disease (IBD). Methods: The epithelial fraction of human ileal mucosa samples from surgical specimens was obtained by laser microdissection. Gene expression was examined by global expression profiling (n = 18, Affymetrix), quantitative reverse-transcription polymerase chain reaction (RT-PCR) (n = 35), immunoblot analysis (n = 9), and immunohistochemistry (n = 25). Results: Global expression profiling revealed a pronounced downregulation of the retinoic acid-inducible gene I (RIG-I) with...

2011-01-01

127

Comparison between children and adolescents with and without chronic benign pain: consultation rate and pain characteristics.  

Science.gov (United States)

The aim of the study was to determine whether children with chronic benign pain are in contact with their general practitioner (GP) more frequently than those without chronic benign pain. A random sample of children and adolescents aged between 0 and 18 years of age was drawn from the records of ten general practices. According to their responses to a pain questionnaire, subjects were assigned to the chronic benign pain group (n = 95) if they had pain of more than three months' duration, or to the control group (n = 105) if they had pain of less than three months' duration or no pain at all. All the subjects had an average GP consultation rate of 2.6 contacts per year. No significant age and sex differences were found. Chronic benign pain in childhood and adolescence is not related to increased use of healthcare services, suggesting that somatisation does not play a major role in children with ...

2002-03-01

128

Platelet thrombosis in cardiac-valve prostheses  

International Nuclear Information System (INIS)

The contribution of platelets and clotting factors in thrombosis on cardiovascular prostheses had been quantified with several tracers. Thrombus formation in vivo could be measured semiquantitatively in animal models and patients with indium-111, Technetium-99m labeled platelets, iodine-123, iodine-131 labeled fibrinogen, and In-111 and Tc-99m labeled antibody to the fibrinogen-receptor on the platelet- membrane, or fibrin. The early studies demonstrated that certain platelet-inhibitors, e.g. sulfinpyrazone, aspirin or aspirin- persantine increased platelet survival time with mechanical valves implanted in the baboon model and patients. Thrombus localization by imaging is possible for large thrombus on thrombogenic surface of prosthesis in the acute phase. The majority of thrombus was found in the sewing ring (Dacron) in the acute phase in both the mechanical and tissue valves. The amount of retained thrombus in both mechanical and tissue valves in our one-day study in the dog model ...

1989-06-08

129

Inhibitory effect of minocycline on osteoclastogenesis in mouse bone marrow cells  

British Library Electronic Table of Contents (United Kingdom)

Objective: To study the effects of minocycline hydrochloride (MINO) on the formation of tartrate-resistant acid phosphatase (TRAP) staining-positive multinucleated osteoclast-like cells in mouse bone marrow cells (BMCs) treated with 1@a,25(OH)"2D"3 or soluble receptor activator of nuclear factor-@kB ligand (s-RANKL). Materials and methods: Mouse BMCs were cultured in alpha-modified minimum essential medium containing foetal calf serum (10%) and tetracyclines (2.5, 5 and 10@mM), such as MINO, tetracycline hydrochloride (TC), oxytetracycline hydrochloride (OXT) or doxycycline (DOXY) in the presence of 1@a,25(OH)"2D"3 (10nM) or s-RANKL (20ng/ml) for 7 days, and the number of TRAP staining-positive osteoclast-like cells was counted. In RNA isolated from BMCs treated with 1@a,25(OH)"2D"3 or s-R...

2011-01-01

130

Influence of nutrition and suckling patterns on the postpartum cyclic activity of swamp buffaloes  

International Nuclear Information System (INIS)

Two studies were conducted to investigate the effects of nutrition and suckling patterns on the ovarian cyclicity of postpartum buffaloes. In Study 1, which was conducted on an institutional farm, two different diets were fed to 24 buffaloes during late gestation and postpartum period. Restricted (twice daily) suckling began on day 30 postpartum in half the animals on each diet. The body weight of both ad libitum suckled and twice daily suckled groups declined during the postpartum period, irrespective of the diet fed. Buffaloes subjected to restricted suckling lost less body weight and re-established ovarian cyclicity earlier than those suckled ad libitum. In Study 2, which was conducted under village conditions, temporary calf removal for 72 hours on days 91-93 postpartum in anoestrous buffaloes induced the re-establishment of ovarian cyclicity within 14 days. (author). 11 refs, 7 tabs.

1989-02-20

131

The role of lesions of DNA in senescence of seeds of Lupinus polyphyllus L. induced by chronic low-intensity irradiation  

International Nuclear Information System (INIS)

A nonlinear relationship between the time of accelerated aging of Lupine seeds and the indices of its survival as well as the single-strand DNA amount in cells from these seeds is established. The character of this relationship is essentially altered in chronically irradiated lupine seeds from the Chernobyl NPP exclusion zone and seems more complicated. The possible role of repair systems in these effects is discussed. The fact that chronic irradiation in low doses can modify the course of senescence in lupine seeds reflects its high biological efficiency comparing with acute irradiation.

2000-08-01

132

The behavioral management of pain: a criticism of a response.  

Science.gov (United States)

In response to an earlier published paper by Fordyce, some assumptions underlying the behavior management paradigm of chronic pain are critically discussed. While operant treatment has proved successful, the conclusion that operant factors play an important role in the development and maintenance of chronic benign pain is debated. Some empirical studies, regularly used to demonstrate this role, are re-evaluated. An alternative theory is proposed for chronic pain behavior, in which the role of a lower tolerance to proprioceptive stimuli, which may include more than just pain stimuli, is emphasized. PMID:3313200

1987-09-01

134

Xanthogranulomatous Salpingitis Associated with a Large Uterine Leiomyoma  

UK PubMed Central (United Kingdom)

A case of xanthogranulomatous salpingitis (XGS) associated with a large uterine leiomyoma in a 50-year-old woman is presented. Xanthogranulomatous inflammation is an uncommon form of chronic inflammation...Full Text Available

2010-01-01

135

Update on Medications With Adverse Skeletal Effects  

UK PubMed Central (United Kingdom)

Patients rely on their primary care physician to manage multiple, often chronic medical conditions that require prescription medications. Balancing the risk to benefit of treatments can be challenging...Full Text Available

2011-04-01

136

Toxicological properties of lead.  

UK PubMed Central (United Kingdom)

The pathological effects of lead on the renal, nervous, reproductive, endocrine, and immune systems have been reviewed. Emphasis is placed on reported subclinical effects due to chronic, low-level lead...Full Text Available

1977-08-01

137

The Burden of Mental Disorders  

UK PubMed Central (United Kingdom)

In the last decade, there has been an increase in interest in the burden of chronic and disabling health conditions that are not necessarily fatal, such as the mental disorders. This review...Full Text Available

2008-01-01

138

Rapidly adapting receptors in a rabbit model of mitral regurgitation  

UK PubMed Central (United Kingdom)

Unlike in normal rabbits, pulmonary rapidly adapting receptors (RARs) in rabbits with chronic mitral regurgitation (MR) do not respond to small changes in extravascular...Full Text Available

1999-12-15

139

Quality and availability of consumer information on heart failure in Australia  

UK PubMed Central (United Kingdom)

BackgroundProvision of consumer information and patient education are considered an essential part of chronic disease management programmes developed for patients with heart failure....Full Text Available

140

Preamputation Pain and Acute Pain Predict Chronic Pain After Lower Extremity Amputation  

British Library Electronic Table of Contents (United Kingdom)

Although previous research suggests that preamputation pain is a risk factor for pain after amputation, little is known about the association between acute postsurgical pain and chronic amputation-related pain. The current prospective study examined the associations of preamputation pain and acute postamputation pain with chronic amputation-related pain. The sample consisted of patients with lower limb amputation (N = 57) who provided both preamputation and postamputation data during a 2-year study period. Preamputation pain intensity and duration were assessed before amputation; acute phantom limb pain (PLP) and residual limb pain (RLP) intensity were assessed on postsurgical days 4 and 5. Acute PLP intensity was the only significant independent predictor of chronic PLP intensity at 6 and...

2007-01-01

142

Paratuberculosis.  

UK PubMed Central (United Kingdom)

Paratuberculosis (Johne's disease) is a chronic, wasting, widespread mycobacteriosis of ruminants. It involves extensive mycobacterial shedding, which accounts for the high contagiousness, and ends...Full Text Available

1994-07-01

143

Oxidative Stress Disrupts Oligodendrocyte Maturation  

UK PubMed Central (United Kingdom)

Periventricular white matter injury (PWMI), is the leading cause of chronic neurologic injury among survivors of preterm birth. The hallmark of PWMI is hypomyelination and a lack of mature,...Full Text Available

2009-11-01

145

Medical Conditions of Nursing Home Admissions  

UK PubMed Central (United Kingdom)

BackgroundAs long-term nursing home care is likely to increase with the aging of the population, identifying chronic medical conditions is of particular interest. Although need factors...Full Text Available

146

Is Phenacetin a Nephrotoxin?  

UK PubMed Central (United Kingdom)

Numerous reports of chronic renal disease in patients who habitually use phenacetin-containing compounds to excess have aroused considerable controversy over the possible relationship between phenacetin,...Full Text Available

1964-08-01

147

Independent Hospital Dialysis in Brunei  

UK PubMed Central (United Kingdom)

In establishing a chronic haemodialysis unit in Brunei the difficulties encountered were less insuperable than had been expected. Quite unsophisticated patients successfully dialysed unattended in...Full Text Available

1971-09-11

148

If I Had - Acne As a Young Female  

Medline Plus

... VIDEO: FASDs Cause More Severe Behavioral Problems Than ADHD, Baking Soda May Slow Chronic Kidney Disease, Higher ...

149

Healthy aging and disease: role for telomere biology?  

UK PubMed Central (United Kingdom)

Aging is a biological process that affects most cells, organisms and species. Human aging is associated with increased susceptibility to a variety of chronic diseases, including cardiovascular disease,...Full Text Available

2011-05-01

150

Gynecologic Pelvic Pain  

UK PubMed Central (United Kingdom)

The family physician dealing with gynecologic pelvic pain (acute or chronic) enters at the beginning of the problem as diagnostician, refers the patient to a specialist in the interim, and resumes...Full Text Available

1989-06-01

151

Focal fits during chlorambucil therapy  

UK PubMed Central (United Kingdom)

An elderly man receiving chlorambucil for chronic lymphatic leukaemia developed focal fits. The onset and frequency were dose related. There was no evidence of metabolic disturbance or of meningeal...Full Text Available

1979-11-01

152

Effects of acute and chronic gamma irradiation on the shoot apex and general morphology of Lupinus albus L  

International Nuclear Information System (INIS)

Lupinus albus L. plants were grown from seeds and irradiated at various stages of development with acute or chronic gamma rays. All plants were greenhouse grown (pre- and post-irradiation) and allowed to proceed through their normal growth cycle. The purpose of these experiments was to establish a Plactochron Index for Lupinus albus L. and to determine the effects of acute and chronic irradiation on development at the macro and microscopic levels. A Plastochron Index was calculated and used as an indirect time scale to evaluate the effects of gamma rays from a common base line. Acute radiation treatment lasted for a period of a few days, whereas chronic treatment was initiated at the seedling stage and lasted for the entire growth season. Vegetative plants were used to study the effects of acute radiation exposure on apical meristem morphology, Plastochron Index, phyllatoxis and gross morphology.

1980-01-01

153

Dietary Phosphorus Acutely Impairs Endothelial Function  

UK PubMed Central (United Kingdom)

Excessive dietary phosphorus may increase cardiovascular risk in healthy individuals as well as in patients with chronic kidney disease, but the mechanisms underlying this risk are not completely understood....Full Text Available

2009-07-01

154

Dendritic Cells in Systemic Lupus Erythematosus  

UK PubMed Central (United Kingdom)

Systemic lupus erythematosus (SLE) persists as a chronic inflammatory autoimmune disease and is characterized by the production of autoantibodies and immune complexes that affects multiple organs....Full Text Available

2010-04-01

155

Critical Limb Ischemia  

UK PubMed Central (United Kingdom)

Opinion statementCritical limb ischemia (CLI), defined as chronic ischemic rest pain, ulcers, or gangrene attributable to objectively proven arterial occlusive disease, is the most advanced...Full Text Available

2010-06-01

156

Clinical significance of unilateral sinusitis.  

UK PubMed Central (United Kingdom)

In general, the etiologic factors of chronic paranasal sinusitis are systemic conditions such as nutrition, predisposition, allergy, and local factors such as nasal anatomic conditions. Among these...Full Text Available

1986-09-01

157

Chronic Recording of Regenerating Vlllth Nerve Axons with a Sieve ...  

Science.gov (United States)

SLPL molecule to stimulate sufficient growth to have nerve sprouts enter the electrode and establish a neural interface for prosthesis control. ...

158

Chronic Pain Associated with Upper-Limb Loss  

UK PubMed Central (United Kingdom)

ObjectiveTo describe the prevalence, intensity, and functional impact of the following types of pain associated with upper-limb loss: phantom limb, residual limb,...Full Text Available

2009-09-01

159

Chronic Disability Syndrome  

UK PubMed Central (United Kingdom)

Prolonged disability is best understood as an illness that exists independently of the initiating disease. The disabled individual goes through predictable stages of disability before resolution occurs....Full Text Available

1991-09-01

160

Cardioprotection conferred by exercise training is blunted by blockade of the opioid system  

UK PubMed Central (United Kingdom)

OBJECTIVES:To investigate the effect of opioid receptor blockade on the myocardial protection conferred by chronic exercise and to compare exercise training with different strategies...Full Text Available

2011-01-01

162

Activation of stem cells in hepatic diseases  

UK PubMed Central (United Kingdom)

The liver has enormous regenerative capacity. Following acute liver injury, hepatocyte division regenerates the parenchyma but, if this capacity is overwhelmed during massive or chronic liver...Full Text Available

2008-01-01

163

Acne keloidalis in females: case report and review of literature.  

UK PubMed Central (United Kingdom)

Acne keloidalis, also known as folliculitis nuchae, is a form of chronic scarring folliculitis characterized by fibrotic papules and nodules of the nape of the neck and the occiput. It particularly...Full Text Available

2005-05-01

164

A Novel Multi-Antigen Virally Vectored Vaccine against Mycobacterium avium Subspecies paratuberculosis  

UK PubMed Central (United Kingdom)

BackgroundMycobacterium avium subspecies paratuberculosis causes systemic infection and chronic intestinal inflammation in many species including...Full Text Available

165

Use of ceramic porous membranes in molten carbonate fuel cells  

Energy Technology Data Exchange (ETDEWEB)

The diffusion of alkali vapours in the anode compartment of a DIR-MCFC produces the deactivation of the internal reforming catalyst. Sets of ceramic porous membranes purposed to limit the diffusion have been manufactured by different techniques and the influence of the preparation technique and of the preparative variables on the morphological characteristics of the membranes structures has been studied.

1996-12-31

166

Request for interim approval to operate Trench 94 of the 218-E-12B Burial Ground as a chemical waste landfill for disposal of polychlorinated biphenyl waste in submarine reactor compartments. Revision 2.  

Science.gov (United States)

This request is submitted to seek interim approval to operate a Toxic Substances Control Act (TSCA) of 1976 chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) waste. Operation of a chemical waste landfill for disposal of PCB waste ...

1994-01-01

167

Request for interim approval to operate 218-E-12B Trench 94 as a chemical waste landfill for disposal of polychlorinated biphenyl wastes in submarine reactor compartments. Revision 1.  

Science.gov (United States)

This request is submitted to seek interim approval to operate a chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) waste. Interim approval is requested for a period not to exceed 5 years. This request covers only the disposal of sm...

1992-01-01

168

Request for interim approval to operate 218-E-12B Trench 94 as a chemical waste landfill for disposal of polychlorinated biphenyl wastes in submarine reactor compartments.  

Science.gov (United States)

This request is submitted to seek interim approval to operate a chemical waste landfill for the disposal of polychlorinated biphenyl (PCB) wastes. This request covers only the disposal of small quantities of solid PCB wastes contained in decommissioned su...

1990-01-01

169

Pharmacokinetic parameters for thallium (I)-ions in man  

Energy Technology Data Exchange (ETDEWEB)

The pharmacokinetics of Tl/sup +/ were studied in 9 patients who underwent myocardial scintigraphy with /sup 201/Tl/sup +/. The time course of the /sup 201/Tl/sup +/ concentration fitted to an open two-compartment model. Using previously published dialysance values the influence of hemodialysis on Tl/sup +/ elimination was calculated. Hemodialysis in Tl/sup +/ intoxications should be moderately effective.

1983-05-01

170

Effect of dietary and synthetic chelating agents on the intestinal absorption of lead. [Rats  

Energy Technology Data Exchange (ETDEWEB)

The effect of a number of dietary and synthetic chelating agents on the intestinal absorption of lead has been examined using the everted sac preparation and the tracer isotope /sup 203/Pb. All the agents examined increased lead transport into the serosal compartment. An explanation of the way in which these agents modify the model to describe lead transport is proposed.

1982-01-01

171

Development of a solution method for the differential equations arising in the biosphere module of the BNFL's suite of codes MONDRIAN  

International Nuclear Information System (INIS)

British Nuclear Fuels plc owns and operates the near-surface Drigg disposal facility for low level radioactive waste. The long-term performance of the site is modelled by a suite of computer codes called MONDRIAN. One of the modules of MONDRIAN deals with the transport of radionuclides through the environment, and this paper reports on the current status of this module (BIOS). We derive the basic set of working equations from first principles and show clearly how the approximate nature of the final equations is arrived at. This is done by an averaging process leading to compartments, in and out of which radionuclides, solids and water can flow. The equations allow radioactive decay chains and an arbitrary number of compartments. There is also the facility to deal with changes in the rate coefficients, thereby simulating different environmental states. It is also possible to include the creation of new compartments arising ...

2002-06-01

172

Design basis for protection of light water nuclear power plants against effects of postulated pipe rupture  

Energy Technology Data Exchange (ETDEWEB)

This standard addresses the design bases for light water reactor, nuclear power plant structures and components essential for the protection of public health and safety from the potential adverse effects of pipe whip, jet impingement, pressurization of compartments outside containment, environmental conditions and flooding associated with a postulated pipe rupture. The design bases for missile protection and the design bases for containment pressurization are not within this standard.

1981-01-01

173

American National Standard: design basis for protection of light water nuclear power plants against effects of postulated pipe rupture  

Energy Technology Data Exchange (ETDEWEB)

This standard addresses the design bases for light water reactor, nuclear power plant structures and components essential for the protection of public health and safety from the potential adverse effects of pipe whip, jet impingement, pressurization of compartments outside containment, environmental conditions and flooding associated with a postulated pipe rupture. The design bases for missile protection and the design bases for containment pressurization are not within this standard.

1980-12-31

174

ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia  

UK PubMed Central (United Kingdom)

The deregulated kinase activity of p210-BCR/ABL oncoproteins, hallmark of chronic myelogenous leukaemia (CML), induces and sustains the leukaemic phenotype, and contributes to disease progression....Full Text Available

2006-10-09

175

Pulmonary function in histology technicians compared with women from Michigan: effects of chronic low dose formaldehyde on a national sample of women.  

UK PubMed Central (United Kingdom)

Chronic workplace exposure to formaldehyde and solvents at low doses reduced pulmonary function in 280 non-smoker white women working as histology technicians. They were studied during national workshops...Full Text Available

1989-07-01

176

Outcome predictability of biomarkers of protein-energy wasting and inflammation in moderate and advanced chronic kidney disease1234  

UK PubMed Central (United Kingdom)

Background: Markers of protein-energy wasting (PEW) and inflammation are common in chronic kidney disease (CKD) and are among the strongest predictors of mortality in dialysis patients.Objective:...Full Text Available

2009-08-01

177

Monoclonal antibodies define genus-specific, species-specific, and cross-reactive epitopes of the chlamydial 60-kilodalton heat shock protein (hsp60): specific immunodetection and purification of chlamydial hsp60.  

UK PubMed Central (United Kingdom)

Ocular and urogenital tract infections with Chlamydia trachomatis can progress to chronic inflammatory diseases that produce blindness and tubal infertility. The pathophysiology of these chronic disease...Full Text Available

1992-06-01

178

Molecular basis of adult-onset and chronic GM2 gangliosidoses in patients of Ashkenazi Jewish origin: substitution of serine for glycine at position 269 of the alpha-subunit of beta-hexosaminidase.  

UK PubMed Central (United Kingdom)

Chronic and adult-onset GM2 gangliosidoses are neurological disorders caused by marked deficiency of the A isoenzyme of beta-hexosaminidase; they occur in the Ashkenazi Jewish population, though less...Full Text Available

1989-04-01

179

Evolution of Hepatitis B Virus in a Chronic HBV-Infected Patient over 2 Years  

UK PubMed Central (United Kingdom)

Mutations in full-length HBV isolates obtained from a chronic HBV-infected patient were evaluated at three time points: 1 day, 6 months, and 31 months. While 5 nucleotides variation, and an 18 bp...Full Text Available

2011-01-01

180

Chronic fatigue syndrome, XMRV and blood safety  

British Library Electronic Table of Contents (United Kingdom)

In the past few months, there has been public discussion relating to a new perspective on blood safety and specifically upon measures to prevent or discourage donation by individuals with a diagnosis of myalgic encephalopathy-chronic fatigue syndrome. This reflects an intriguing interplay between science, public health and public concern and illustrates some of the difficulties of making decisions in the face of uncertainty and inadequate information.

2011-01-01

181

Decommissioning of French nuclear submarines  

Energy Technology Data Exchange (ETDEWEB)

Since the beginning of the sixties, France has developed a fleet of nuclear powered vessels. Insofar as the ships of the 2. generation are being built, the older ones are decommissioned and enter the dismantling process. The average rate is presently one submarine decommissioned every two or three years. The overall strategy for the decommissioning of French nuclear submarines can be brought down to 3 phases: 1. Level 1 dismantling which essentially consists in: - unloading the spent fuel and storing it in a pool ; - possibly emptying the circuits which contain radioactive liquids. The level 1 is easily achieved, as it is not very different from the plant situation during ship overhaul or major refits. 2. Level 2 dismantling which consists in isolating the nuclear reactor compartment from the rest of the submarine and conditioning it for interim storage on a ground facility located inside Cherbourg Naval Dockyard. The rest of the ship is decontaminated, controlled ...

2003-07-01

182

[Clinico-hormonal correlations in patients with chronic alcoholic intoxication].  

Science.gov (United States)

Radioimmunochemical assay was used to study the hypophyseal and peripheral hormones activity in 60 patients with chronic alcoholism, stage II. A correlation has been established between the patient's age and prolactin and FSH concentrations, as well as between the duration of the recent hard drinking and the concentrations of prolactin, testosterone, FSH and interstitial cell stimulating hormone. It has been shown that the manifestation of the alcoholic abstinent syndrome depended on the prolactin concentration. The test sensitivity estimated by the prolactin level rise and the testosterone level reduction reached 92.3%. The specificity of the changes detected comprised 25%. A conclusion has been made that the disorders noted in the patients with chronic alcoholic intoxication can be used as an objective test in the alcoholism diagnosis. PMID:3936321

1985-01-01

183

[Characteristics of the clinical picture and course of chronic alcoholic intoxication in patients with various types of neuroendocrine changes].  

Science.gov (United States)

Clinical and hormonal indices of androgenic activity were compared in 118 males chronically intoxicated with alcohol. The population was divided into two groups with respect to their clinical and hormonal androgenic indices: 76 patients with (Group 1), and 46 patients without (Group 2) androgenic insufficiency. Distinct signs and syndromes of alcohol addiction were shown to correlate with the extent of cross-regulation impairment within hypothalamo-hypophyseo-gonadal system. This was particularly derived from comparison of clinical picture of chronic alcohol intoxication and hormone activity in the groups. Conventional therapy failed to restore the neuroendocrine indices that was apparently due to inhibition of cross-regulation links in the hypothalamo-hypophyseo-gonadal system at several stages of alcohol addiction. PMID:3223149

1988-01-01

184

Stress-induced alterations in anxiety-like behavior and adaptations in plasticity in the bed nucleus of the stria terminalis  

British Library Electronic Table of Contents (United Kingdom)

In vulnerable individuals, exposure to stressors can result in chronic disorders such as generalized anxiety disorder (GAD), major depressive disorder (MDD), and post-traumatic stress disorder (PTSD). The extended amygdala is critically implicated in mediating acute and chronic stress responsivity and anxiety-like behaviors. The bed nucleus of the stria terminalis (BNST), a subregion of the extended amygdala, serves as a relay of corticolimbic information to the paraventricular nucleus of the hypothalamus (PVN) to directly influence the stress response. To investigate the influence of the corticosteroid milieu and housing conditions on BNST function, adult C57Bl/6J were either acutely or chronically administered corticosterone (CORT, 25mg/kg in sesame oil) or vehicle (sesame oil) or were g...

2011-01-01

185

Sexual function in women receiving maintenance dialysis  

British Library Electronic Table of Contents (United Kingdom)

Abstract While substantial attention has been paid to the issue of sexual dysfunction in men on chronic dialysis, less is known about this problem in women with end-stage renal disease. We sought to assess sexual dysfunction in women on chronic dialysis and determine whether patients discuss this problem with their providers and receive treatment. We prospectively enrolled women receiving chronic hemodialysis or peritoneal dialysis in Pittsburgh, PA. We asked patients to complete the 19-item Female Sexual Function Index (FSFI) to assess sexual function and a 5-item survey that assessed whether patients had discussed sexual dysfunction with their providers and/or received treatment for this problem in the past. We enrolled 66 patients; 59 (89%) on hemodialysis and 7 (11%) on peritoneal dial...

2010-01-01

186

Magnetic resonance imaging of chronic aortic dissection  

International Nuclear Information System (INIS)

17 patients with chronic aortic dissection were examined by MRI. In 12 patients, comparison between gradient echo sequences and SE sequences was possible. Gradient echo sequences, unlike SE sequences, permitted evaluation of flow in the true and false lumen, reliable differentiation between thrombus and flowing blood and clear delination of the intimal flap. An additional comparison between transoesophageal ultrasound and MRT in 15 patients showed significant advantages in favour of MRI. In three patients MRI was able to detect more proximal origins of the dissection. Moreover, MRI allowed evaluation of the major aortic branches and their relation to the dissection; this was not possible with ultrasound. MRI plays an important role in the follow-up of chronic aortic dissections. (orig.).

187

Lipid composition of liver microsomes and mitochondria after acute and chronic {gamma}-irradiation of rats  

Energy Technology Data Exchange (ETDEWEB)

Acute {gamma}-irradiation of rats at doses of 100 and 270 Gy stimulates lipid synthesis and changes the lipid composition of liver cell organelles. The content of cholesterol and cholesterol esters in microsomes increased at 100 Gy and decreased at 270 Gy, with total phospholipid content remaining unchanged. The lipid content in mitochondria decreased considerably 1 h after irradiation at 270 Gy. This change was significantly less pronounced 47 h later. Under chronic {gamma}-irradiation (0.129 Gy/day), cholesterol and cardiolipin in mitochondria increased. The changes in lipid content caused by acute irradiation are presumed to be related to activated synthesis of lipids in the liver. The modification of the lipid content of mitochondria observed in chronically irradiated rats may indicate that energy-metabolizing liver cell systems are involved in the adaptation to irradiation.

1994-07-01

188

Intestinal Ischemia for estenosis of the superior mesenteric artery, Treatment with angioplastia and stent implant  

International Nuclear Information System (INIS)

Chronic mesenteric arterial ischemia is an uncommon condition associated a high morbidity and mortality. It is most Commonly caused by atherosclerotic occlusive disease. Patients may suffer epigastric or periumbilical postprandial pain ten to thirty minutes after eating. A case of chronic mesenteric artery stenosis, the diagnosis was performance with colonoscopy and biopsy. We present a case report of a patient with chronic mesenteric ischemia. Mesenteric arteriography was performed and documented estenosis of the mesenteric superior artery. Then percutaneous arteriography with angioplasty and implant of stent was performed. The patients became completely asymptomatic and normal colon mucous is observed in control colonoscopy. The purpose of this report is to present the case endoscopy, clinic and radiological features and to describe the percutaneous angioplasty and implant of stent. We believe that angioplasty treatment ...

189

Image diagnosis of parathyroid glands in chronic renal failure  

Energy Technology Data Exchange (ETDEWEB)

Twenty-two out of 31 patients with chronic renal failure and secondary hyperparathyroidism who underwent parathyroidectomy before operation underwent non-invasive image diagnosis of parathyroid glands by computed tomography (CT), scintigraphy with /sup 201/TlCl and /sup 99m/TcO/sup 4 +/, and/or ultrasonography. CT visualized 39 of 45 parathyroid glands (86.7%), weighing more than 500 mg. Scintigraphy with a subtraction method using a computer performed the diagnosis in 19 of 27 glands (70.4%). Ultrasonography detected 21 of 27 glands (77.8%). Image diagnosis was also useful in the postoperative follow-up study. The non-invasive image diagnosis of parathyroid glands in patients with chronic renal failure is thus valuable for 1) definite diagnosis of secondary hyperparathyroidism, 2) localization, and 3) diagnosis for effectiveness of conservative treatment.

1983-07-01

190

Histological analysis of 70-nm silica particles-induced chronic toxicity in mice  

British Library Electronic Table of Contents (United Kingdom)

Nano-sized silica is a promising material for disease diagnosis, cosmetics and drugs. For the successful application of nano-sized material in bioscience, evaluation of nano-sized material toxicity is important. We previously found that nano-sized silica particles with a diameter of 70nm showed acute liver failure in mice. Here, we performed histological analysis of major organs such as the liver, spleen, lung, kidney, brain and heart in mice, chronically injected with 70-nm silica particles for 4weeks. Histological analysis revealed hepatic microgranulation and splenic megakaryocyte accumulation in these 70-nm silica particles treated mice, while the kidney, lung, brain and heart remained unaffected. Thus, liver and spleen appear to be the major target organs for toxicity by the chronic a...

2009-01-01

191

Chronic maternal stress affects growth, behaviour and hypothalamo?pituitary?adrenal function in juvenile offspring  

British Library Electronic Table of Contents (United Kingdom)

Maternal stress during pregnancy, particularly that combined with low socioeconomic status (SES), has been linked to an increased risk for impaired behavioural and emotional development and affective disorders in children. In animal models, acute periods of prenatal stress have profound effects on hypothalamo-pituitary-adrenal (HPA) function and behaviour. However, few studies have determined the impact of chronic exposure to stress in animal models. The objective of this study was to determine the effects of chronic maternal stress (CMS) during the 2nd half of pregnancy and nursing on growth, locomotor behaviour and HPA axis function in juvenile guinea pig offspring. Pregnant guinea pigs were exposed to a random combination of variable stressors every other day over the 2nd half of gestat...

2008-01-01

192

Radiation Chemistry of Aqueous Solutions Related to Nuclear Reactor Systems and Spent Fuel Management  

International Nuclear Information System (INIS)

In this thesis the rate constants for a number of radical reactions in aqueous solution have been studied in a wide temperature range. The reactions of H with H_2O_2, OH and HO_2 and the reactions of HO_2 with OH, Fe"2"+ and Cu"2"+ have been studied. For each reaction rate constants have been determined as a function of temperature using the technique of high temperature, high pressure (HTP) pulse radiolysis. The rate constants were obtained by fitting a kinetic computer model to the experimental data. From an Arrhenius plot the activation energy of each reaction was determined. The data determined in this way are important for modeling of radiolysis in nuclear light water reactors. A previously developed model for calculation of the effect of water radiolysis products on oxidation and dissolution of spent nuclear fuel has been improved. In the new model, called TraRaMo, simultaneous transport by diffusion and chemical reactions induced by radiolysis can be modeled. The model is a ...

2003-01-01

193

Quantification of antibiotic drug potency by a two-compartment radioassay of bacterial growth  

Energy Technology Data Exchange (ETDEWEB)

The two-compartment radioassay for microbial kinetics based on continuous measurement of the {sup 14}CO{sub 2} released by bacterial metabolism of 14C-labeled substrate offers a valuable approach to testing the potency of antimicrobial drugs. By using a previously validated radioassay with gram-positive and gram-negative bacteria, a group of protein synthesis inhibitors was evaluated for their effect on microbial growth kinetics. All tested drugs induced changes in both the slopes and intercepts of the growth curves. An exponential growth model was applied to quantify the drug effect on the processes of bacterial {sup 14}CO{sub 2} liberation and cell generation. The response was measured in terms of a generation rate constant. A linear dependence of the generation rate constant on the dose of spectinomycin was observed with Escherichia coli. Sigmoidal-shaped curves were found in the assays of chloramphenicol and tetracycline. The implications of dose-response ...

1990-06-01

194

Implementation of the NCRP wound model for interpretation of bioassay data for intake of radionuclides through contaminated wounds.  

Science.gov (United States)

Emergency response preparedness for radiological accidents involving wound contamination has become more important, considering the current extending tendency in the nuclear industry related to the nuclear fuel cycle. The US National Council on Radiation Protection and Measurements (NCRP) proposed a biokinetic and dosimetric model for the intake of radionuclides through contaminated wounds in 2007. The present paper describes the implementation of this NCRP wound model for the prediction of systemic behaviour of some important radioactive elements encountered in workplaces related to the nuclear industry. The NCRP wound model was linked to the current ICRP systemic model at each blood compartment and simultaneous differential equations for the content of radioactivity in each compartment and excreta were solved with the Runge-Kutta method. The results of the calculation of wound, whole-body or specific organ retention and daily urinary or ...

2009-05-01

195

Hydrogen utilization efficiency in PEM fuel cells  

Energy Technology Data Exchange (ETDEWEB)

In this paper, we present the work carried out within the framework of the FEVER project (Fuel cell Electric Vehicle for Efficiency and Range), an European project coordinated by Renault, joining Ecole des Mines de Paris, Ansaldo, De Nora, Air Liquide and Volvo. For the FEVER project, where an electrical air compressor is used for oxidant supply, there is no need for hydrogen spill over, meaning that the hydrogen stoichiometry has to be as close to one as possible. To determine the optimum hydrogen utilization efficiency for a 10 kW Proton Exchange Membrane Fuel Cell (PEMFC) fed with pure hydrogen, a 4 kW prototype fuel cell was tested with and without a hydrogen recirculator at the test facility of Ecole des Mines de Paris. Nitrogen cross over from the cathodic compartment to the anodic compartment limits the hydrogen utilization of the fuel cell without recirculator to 97.4 % whereas 100% is feasible when a recirculator is used. 5 refs.

1998-07-01

196

Evaluation of pipe whip impacts on neighboring piping and walls of the Ignalina Nuclear Power Plant  

Energy Technology Data Exchange (ETDEWEB)

Stress corrosion cracks have been discovered in Group Distribution Headers (GDH) at the Ignalina and Chernobyl Nuclear Power Plants. This increases the probability that a guillotine pipe break can occur that creates a whipping pipe (GDH) with the potential to damage surrounding structures-i.e. adjacent GDH and its attached piping or adjacent reinforced concrete compartment wall. The GDH is the most important component for reactor safety in case of an accident. Emergency Core Cooling System (ECCS) piping is connected to the GDH piping such that, during an accident, coolant passes from the ECSS into the GDH. Presented in this paper is the transient analysis of a Group Distribution Header following a guillotine break at the blind end of the header. Using a very conservative force loading function, the transient response of a whipping RBMK-1500 GDH along with neighboring concrete walls and pipelines is obtained using finite element methodology. The results of the ...

2007-04-15

197

Sonography and Computed Tomography in the evaluation of giant Baker's cysts  

International Nuclear Information System (INIS)

The US study of the posterior compartment of the knee usually allows the clinical suspicion of popliteal cyst to be confirmed. Neverthless, in case of giant Baker's cysts - which are, at any rate, less frequent -US diagnosis is more difficult. CT can help determine the benign nature of the lesion, and hallow an accurate spatial evaluation. Moreover CT, when accurately performed, demonstrates the caudal or cranial cystic spread, together with its clear separation from adjacent muscular tissues. Direct coronal scans are more useful to obtain better spatial definition than reformatted images.

1991-01-01

198

Overview of macroautophagy regulation in mammalian cells  

British Library Electronic Table of Contents (United Kingdom)

Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal compartment, and it is of fundamental importance in tissue homeostasis. In this review, we consider macroautophagy in the light of recent advances in our understanding of the formation of autophagosomes, which are double-membrane-bound vacuoles that sequester cytoplasmic cargos and deliver them to lysosomes. In most cases, this final step is preceded by a maturation step during which autophagosomes interact with the endocytic pathway. The discovery of AuTophaGy-related genes has greatly increased our knowledge about the mechanism responsible for autophagosome formation, and there has also been progress in the understanding of molecular aspects of autophagosome maturation. Finally, the regulation of au...

2010-01-01

199

Metabolism of benzo(a)pyrene by isolated perfused testis and testicular homogenate  

Energy Technology Data Exchange (ETDEWEB)

In an effort to improve the extrapolation of laboratory data to man and estimate risk of human reproductive toxicity associated with environmental exposure, the pharmacokinetic parameters of the testicular compartment are being studied. Of particular interest is the variety of enzyme systems capable of activating and detoxicating environmental chemicals and drugs. This report compares the metabolism of benzo(a)pyrene by the isolated perfused testis and testicular homogenates in vitro. The cell free in vitro system metabolized benzo(a)pyrene at a much greater rate than the perfused testis and produced a different spectrum of metabolites. Reliable laboratory prediction of biotransformation by the whole organ or intact animal is an essential aspect of reproductive toxicology.

1980-12-01

200

Global Dissipative Dynamics of the Extended Brusselator System  

CERN Document Server

The existence of a global attractor for the solution semiflow of the extended Brusselator system in the $L^2$ phase space is proved, which is a cubic-autocatalytic and partially reversible reaction-diffusion system with linear coupling between two compartments. The method of grouping and re-scaling estimation is developed to deal with the challenge in proving the absorbing property and the asymptotic compactness of this typical multi-component reaction-diffusion systems. It is also proved that the global attractor is an $(H, E)$ global attractor with the $L^\\infty$ regularity and that the Hausdorff dimension and the fractal dimension of the global attractor are finite. The results and methodology can find many applications and further extensions in complex biological and biochemical dynamical systems.

2011-01-01

201

Comprehensive view of BMFT-funded research on forest decline. Gesamtdarstellung der oeffentlich gefoerderten Forschung ueber Waldschaeden  

Energy Technology Data Exchange (ETDEWEB)

Since 1983, about 600 research projects received a total of DM 250 million public funds for the following tasks: - Development of scientific fundamentals for monitoring and observation of forest decline and its ecological and economic consequences. - Investigation of the cause-effect relationship of forest damage, with particular regard to the involvement of the various compartments of the forest ecosystem and to the contribution of different pollutants. - Development of the scientific fundamentals required for forestry measures to accompany the air pollution abatement measures. The investigations comprised both laboratory and field tests. The findings and conclusion are summarized. (orig./MG).

1988-12-01

202

Translocation of particles to the pleural space and tracheobronchial lymph nodes following lung deposition  

Energy Technology Data Exchange (ETDEWEB)

The translocation of particles from the alveolar compartment to the pleural space and tracheobronchial lymph nodes was investigated in rats over a 30 day period following the intrapulmonary instillation of 4 x 10/sup 8/ polystyrene microspheres (1.9 ..mu..m dia.). In initial studies, approx. =10/sup 4/ particles were found in the pleural space compartment on Days 1, 14 and 30 after particle deposition, and most of these were cell-associated. Subsequent pleural space studies indicated, however, that the particles found in this compartment were, at least in part, due to the pleural lavage technique, and, unlike observations reported for some fibers, the translocation of the particles used in our study to the pleural space does not represent an important lung clearance pathway. In regard to particle clearance to the tracheobronchial lymph nodes, the accumulation of particles, most of which were extracellular, kinetically was ...

1985-01-01

203

Prediction of response of blood lead to airborne and dietary lead from volunteer experiments with lead isotopes  

Energy Technology Data Exchange (ETDEWEB)

To predict the response of blood lead to airborne and dietary lead requires knowledge of the rate of uptake of lead into the body from lung and gut, its subsequent partitioning between compartments, the stay time in those compartments, and its redistribution or excretion. Tracer studies with volunteers have shown no differences in systemic distribution of inorganic lead between tissues whether it is taken by inhalation, ingestion or injection. Lead is rapidly transferred from plasma to red cells, and there is slower movement thence into liver and other soft tissues, to bone, and to excreta. Work at Harwell and elsewhere with /sup 203/Pb has shown that the initial rapid distribution leaves rather over half the assimilated lead attached to red cells. The result is remarkably consistent, and applies also to dogs and baboons. The renal clearance (Vu) (ratio of U to CB, or daily urinary output expressed as mass of blood having the same lead ...

1985-04-22

204

Low concentrations of primaquine inhibit degradation but not receptor-mediated endocytosis of asialoorosomucoid by HepG2 cells  

Energy Technology Data Exchange (ETDEWEB)

Asialoorosomucoid (ASOR) is internalized and degraded by HepG2 cells after binding to the asialoglycoprotein (ASGP) receptor, internalization through the coated pit/coated vesicle pathway, and trafficking to lysosomes. Primaquine, an 8-aminoquinoline antimalarial compound, inhibits ASOR degradation at concentrations greater than 0.2 mM by neutralizing intracellular acid compartments. This leads to alterations in surface receptor number, receptor-ligand dissociation, and receptor recycling. We have investigated the effects of primaquine on 125I-ASOR uptake and degradation as a function of primaquine concentration and duration of exposure. Concentrations below those required for neutralization of acidic compartments block 125I-ASOR degradation in HepG2 cells and lead to intracellular ligand accumulation. This effect is maximal at 80 microM primaquine. The intracellular 125I-ASOR is undegraded, dissociated from the ASGP receptor, and contained ...

1991-02-01

205

Low concentrations of primaquine inhibit degradation but not receptor-mediated endocytosis of asialoorosomucoid by HepG2 cells  

International Nuclear Information System (INIS)

Asialoorosomucoid (ASOR) is internalized and degraded by HepG2 cells after binding to the asialoglycoprotein (ASGP) receptor, internalization through the coated pit/coated vesicle pathway, and trafficking to lysosomes. Primaquine, an 8-aminoquinoline antimalarial compound, inhibits ASOR degradation at concentrations greater than 0.2 mM by neutralizing intracellular acid compartments. This leads to alterations in surface receptor number, receptor-ligand dissociation, and receptor recycling. We have investigated the effects of primaquine on 125I-ASOR uptake and degradation as a function of primaquine concentration and duration of exposure. Concentrations below those required for neutralization of acidic compartments block 125I-ASOR degradation in HepG2 cells and lead to intracellular ligand accumulation. This effect is maximal at 80 microM primaquine. The intracellular 125I-ASOR is undegraded, dissociated from the ASGP receptor, and contained ...

206

Influence of sedation and data acquisition method on tracer uptake in animal models: ["1"2"3I]-2-iodo-L-phenylalanine in pentobarbital-sedated tumor-bearing athymic mice  

International Nuclear Information System (INIS)

Objectives: To minimize movement artifacts during tracer imaging studies, the animals are generally sedated. Although many reports describe the effect of barbiturates on brain function, less is published about the general impact on the extracerebral metabolism and tracer biodistribution. This report describes the influence of pentobarbital on tumor uptake of ["1"2"3I]-2-iodo-L-phenylalanine (["1"2"3I]-2I-L-PA) using dissection and nuclear imaging. Methods: R1M tumor-bearing athymic mice were divided into two populations: untreated and pentobarbital-treated. Each group was subjected to dynamic and static planar imaging and organ dissection after ["1"2"3I]-2I-L-PA injection. Two-compartment blood modeling was performed. Analysis of variance (ANOVA), t test and clustered boxplot analyses were used to compare the results between the treatment groups and between the data acquisition methods. Results: Two-compartment blood modeling demonstrated that ...

2006-01-01

207

Estimation of the parameter covariance matrix for aone-compartment cardiac perfusion model estimated from a dynamic sequencereconstructed using map iterative reconstruction algorithms  

Energy Technology Data Exchange (ETDEWEB)

In dynamic cardiac SPECT estimates of kinetic parameters ofa one-compartment perfusion model are usually obtained in a two stepprocess: 1) first a MAP iterative algorithm, which properly models thePoisson statistics and the physics of the data acquisition, reconstructsa sequence of dynamic reconstructions, 2) then kinetic parameters areestimated from time activity curves generated from the dynamicreconstructions. This paper provides a method for calculating thecovariance matrix of the kinetic parameters, which are determined usingweighted least squares fitting that incorporates the estimated varianceand covariance of the dynamic reconstructions. For each transaxial slicesets of sequential tomographic projections are reconstructed into asequence of transaxial reconstructions usingfor each reconstruction inthe time sequence an iterative MAP reconstruction to calculate themaximum a priori reconstructed estimate. Time-activity curves for a sumof activity in a blood ...

2004-01-01

208

Variants in Inflammation Genes and the Risk of Biliary Tract Cancers and Stones: A Population-based Study in China  

UK PubMed Central (United Kingdom)

To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), including...Full Text Available

2008-08-01

209

Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease  

UK PubMed Central (United Kingdom)

Objective:The identification of biological markers in order to assess different aspects of COPD is an area of growing interest. The objective of this study was to investigate whether...Full Text Available

2011-01-01

210

Uneven dietary development: linking the policies and processes of globalization with the nutrition transition, obesity and diet-related chronic diseases  

UK PubMed Central (United Kingdom)

In a "nutrition transition", the consumption of foods high in fats and sweeteners is increasing throughout the developing world. The transition, implicated in the rapid rise of obesity and diet-related...Full Text Available

211

Tumor necrosis factor-? serum levels in healthy smokers and nonsmokers  

UK PubMed Central (United Kingdom)

Background:Tobacco smoking is the most important risk factor for chronic obstructive pulmonary disease (COPD) development. Inhaled cigarette smoke can induce tumor necrosis factor-α...Full Text Available

2010-01-01

212

Toxicity and carcinogenicity studies of boric acid in male and female B6C3F1 mice.  

UK PubMed Central (United Kingdom)

Toxicity and potential carcinogenicity studies of boric acid were investigated in mice to verify in a second rodent species that this was a noncarcinogenic chemical. Earlier chronic studies in rats...Full Text Available

1994-11-01

213

Timing of Erythropoiesis-Stimulating Agent Initiation and Adverse Outcomes in Nondialysis CKD: a Propensity-Matched Observational Study  

UK PubMed Central (United Kingdom)

Background and objectives: The severity of anemia at which to initiate erythropoiesis-stimulating agent (ESA) treatment in nondialysis chronic kidney disease (CKD) patients is unclear. Risk of mortality,...Full Text Available

2010-05-01

214

The treatment of chronic pain by epidural spinal cord stimulation--a 15 year follow up; present status.  

Science.gov (United States)

Pain is necessary for survival but chronic pain is disabling and causes significant health and economic problems. This study provides an understanding of the future for spinal cord stimulation. Stimulation by means of chronically implanted electrodes, was carried out in 200 patients with pain of varied benign organic etiology. In 177 of them, pain was confined to the failed back syndrome. Most patients were referred by a Pain Management Service. 226 epidural implants were used: 80 unipolar, 59 Resume, 12 bipolar, and 75 quadripolar. Patients were followed for periods of 6 months to 12 years, with a mean follow-up of 44 months. 84 patients (42%) were able to control their pain by stimulation alone, 22 patients (11%) needed occasional analgesic supplements along with their stimulation program. Pain secondary to failed back syndrome, multiple sclerosis, peripheral vascular disease, sympathetic dystrophy and diabetic neuropathy responded favorably. ...

1997-06-01

215

The role of cryoanalgesia for chronic thoracic pain: results of a long-term follow up.  

UK PubMed Central (United Kingdom)

Cryoanalgesia (the use of cold to provide anesthesia or analgesia) is the oldest anesthetic and analgesic still in current clinical use. Its intraoperative use in providing postoperative analgesia for...Full Text Available

2002-08-01

216

The musculoskeletal effects of diabetes mellitus  

UK PubMed Central (United Kingdom)

Diabetes mellitus (DM) is a multi-system disease characterized by persistent hyperglycemia that has both acute and chronic biochemical and anatomical sequelae, with Type-2 DM representing the most common...Full Text Available

2006-03-01

217

The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN study*  

UK PubMed Central (United Kingdom)

Chronically elevated interleukin-6 (IL-6) affects lipid and lipoprotein metabolism. Individuals genetically predisposed to higher IL-6 secretion may be at risk of dyslipidemia, especially during the...Full Text Available

2008-08-01

218

The causes, consequences, and treatment of left or right heart failure  

UK PubMed Central (United Kingdom)

Chronic heart failure (HF) is a cardiovascular disease of cardinal importance because of several factors: a) an increasing occurrence due to the aging of the population, primary and secondary prevention...Full Text Available

2011-01-01

219

The Role of Placental Homeobox Genes in Human Fetal Growth Restriction  

UK PubMed Central (United Kingdom)

Fetal growth restriction (FGR) is an adverse pregnancy outcome associated with significant perinatal and paediatric morbidity and mortality, and an increased risk of chronic disease later in adult life....Full Text Available

2011-01-01

220

The Medical Home Concept and Congenital Adrenal Hyperplasia: A Comfortable Habitat!  

UK PubMed Central (United Kingdom)

Patient-centered interdisciplinary health care for children with chronic medical disorders represents an evolution from the traditional “stop and go” treatment for acute illnesses. This...Full Text Available

2010-01-01

221

Symptom Burden, Depression, and Quality of Life in Chronic and End-Stage Kidney Disease  

UK PubMed Central (United Kingdom)

Background and objectives: While many patients with end-stage renal disease (ESRD) have impaired physical and psychologic well-being, less is known about these health domains in patients with advanced...Full Text Available

2009-06-01

222

Statistical methods for the blood beryllium lymphocyte proliferation test.  

UK PubMed Central (United Kingdom)

The blood beryllium lymphocyte proliferation test (BeLPT) is a modification of the standard lymphocyte proliferation test that is used to identify persons who may have chronic beryllium disease. A major...Full Text Available

1996-10-01

223

Spouse Beliefs about Partner Chronic Pain  

UK PubMed Central (United Kingdom)

While research has shown that patients’ beliefs about their pain are related to pain adjustment and treatment outcomes, little is known about the beliefs of their significant others....Full Text Available

2009-05-01

224

Shedding New Light on Early Caries Detection  

UK PubMed Central (United Kingdom)

Dental caries continues to be a common chronic disease among various population groups. Patient care can be improved with detection at the earliest stage. However, current techniques do not...Full Text Available

2008-12-01

225

Sex and Hormonal Variations in the Development of At-level Allodynia In a Rat Chronic Spinal Cord Injury Model  

UK PubMed Central (United Kingdom)

The development of central neuropathic pain varies among patients with spinal cord injury (SCI). The factors contributing to the development and perpetuation of segmental pain (at-level allodynia)...Full Text Available

2010-06-25

226

Serum Potassium and Outcomes in CKD: Insights from the RRI-CKD Cohort Study  

UK PubMed Central (United Kingdom)

Background and objectives: The relationship between serum potassium (SK) and mortality in chronic kidney disease (CKD) has not been systematically investigated.Design, setting, participants,...Full Text Available

2010-05-01

227

Rome II Versus Rome III Classification of Functional Gastrointestinal Disorders in Pediatric Chronic Abdominal Pain  

UK PubMed Central (United Kingdom)

ObjectivesThe updated Rome III criteria for pediatric functional gastrointestinal disorders (FGIDs) include new FGID categories and changes to the Rome II criteria...Full Text Available

2008-09-01

228

Results of a multicenter trial comparing imipenem/cilastatin to tobramycin/clindamycin for intra-abdominal infections.  

UK PubMed Central (United Kingdom)

We designed a multicenter study to compare tobramycin/clindamycin to imipenem/cilastatin for intra-abdominal infections. We included the Acute Physiology and Chronic Health Evaluation (APACHE II) index...Full Text Available

1990-11-01

229

Reliability and Validity of an Internet-based Questionnaire Measuring Lifetime Physical Activity  

UK PubMed Central (United Kingdom)

Lifetime exposure to physical activity is an important construct for evaluating associations between physical activity and disease outcomes, given the long induction periods in many chronic diseases....Full Text Available

2010-11-15

230

Prevalence and determinants of pain and pain-related disability in urban and rural settings in southeastern Ontario  

UK PubMed Central (United Kingdom)

BACKGROUND:Canadian chronic pain prevalence estimates range from 11% to 66%, are affected by sampling and measurement bias, and largely represent urban settings.OBJECTIVES:To...Full Text Available

2006-01-01

231

Preemptive analgesia: the prevention of neurogenous orofacial pain.  

UK PubMed Central (United Kingdom)

Chronic neurogenous pain is often an extremely difficult condition to manage. In the orofacial region, trauma from injury or dental procedures may lead to the development of severe neuralgic pains and...Full Text Available

1995-01-01

232

Predictivity of survival according to different equations for estimating renal function in community-dwelling elderly subjects  

UK PubMed Central (United Kingdom)

Background. Detection of subjects with early chronic kidney disease (CKD) is important because some will progress up to stage 5 CKD, and most are at high risk of cardiovascular morbidity...Full Text Available

2009-04-01

233

Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis  

UK PubMed Central (United Kingdom)

BackgroundThe long latent stage seen in syphilis, followed by chronic central nervous system infection and inflammation, can be explained by the persistence of atypical cystic and...Full Text Available

234

Pain characteristics of adults 65 years of age and older referred to a tertiary care pain clinic  

UK PubMed Central (United Kingdom)

BACKGROUND:Reports indicate that characteristics of older adults with chronic pain may be different than those of younger persons.OBJECTIVE:To study...Full Text Available

2008-09-01

235

Paediatric Palliative Care: Theory to Practice  

UK PubMed Central (United Kingdom)

Paediatric palliative care is a holistic approach aimed at addressing the complex issues related to the care of children and families facing chronic life limiting illnesses. The needs of children are...Full Text Available

2011-01-01

236

PAGETOID RETICULOSIS IN A 5 YEAR OLD BOY  

UK PubMed Central (United Kingdom)

We present a rare case of pagetoid reticulosis arising in a five year old white boy. He had a history of a large chronic erythematous, scaly patch on his left buttock that had shown intermittent...Full Text Available

2008-04-01

237

P2Y2 Nucleotide Receptor-Mediated Responses in Brain Cells  

UK PubMed Central (United Kingdom)

Acute inflammation is important for tissue repair; however, chronic inflammation contributes to neurodegeneration in Alzheimer’s disease (AD) and occurs when glial cells undergo prolonged...Full Text Available

2010-06-01

238

Over-the-scope clip closure of two chronic fistulas after gastric band penetration  

UK PubMed Central (United Kingdom)

Gastrointestinal perforations are conservatively managed at endoscopy by through-the-scope endoclips and covered self expandable stents, according to the size and tissue features of the perforation....Full Text Available

2010-04-07

239

Outcomes Associated with Race in Males with Nondialysis-Dependent Chronic Kidney Disease  

UK PubMed Central (United Kingdom)

Background and objectives: Blacks are over-represented among dialysis patients, but they have better survival rates than whites. It is unclear if the over-representation of blacks on dialysis is due...Full Text Available

2009-05-01

240

Origin of XMRV and its Demise as a Human Pathogen Associated with Chronic Fatigue Syndrome  

UK PubMed Central (United Kingdom)

Retroviruses are well known pathogens of mammals, birds and fish. Their potential to induce cancer in chickens was already described almost 100 years ago and murine retroviruses have been a subject...Full Text Available

241

Ocular side effects of anti-rheumatic medications: what a rheumatologist should know  

UK PubMed Central (United Kingdom)

Nearly every drug may cause changes to ocular tissues through a variety of mechanisms. Medication overdoses, drug–drug interactions but also chronic administration of medications at...Full Text Available

2010-01-01

242

Nonclinical Safety Profile of Telbivudine, a Novel Potent Antiviral Agent for Treatment of Hepatitis B?  

UK PubMed Central (United Kingdom)

Telbivudine is a novel nucleoside drug recently approved for the treatment of patients with chronic hepatitis B. Its nonclinical safety was evaluated in a comprehensive program of studies, including...Full Text Available

2008-07-01

243

Nocturnal sleep, daytime sleepiness, and quality of life in stable patients on hemodialysis  

UK PubMed Central (United Kingdom)

BackgroundAlthough considerable progress has been made in the treatment of chronic kidney disease, compromised quality of life continues to be a significant problem for patients...Full Text Available

244

Multicomponent Breath Analysis With Infrared Absorption Using Room-Temperature Quantum Cascade Lasers  

UK PubMed Central (United Kingdom)

Breath analysis is a powerful noninvasive technique for the diagnosis and monitoring of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). Nitric oxide...Full Text Available

2009-12-11

245

Morules in endometrial carcinoma and benign endometrial lesions differ from squamous differentiation tissue and are not infected with human papillomavirus  

UK PubMed Central (United Kingdom)

Background: Squamous differentiation/squamous metaplasia is often associated with endometrial adenocarcinoma and benign lesions, such as endometrial hyperplasia and chronic endometritis....Full Text Available

2004-09-01

246

Liver Flukes: the Malady Neglected  

UK PubMed Central (United Kingdom)

Liver fluke disease is a chronic parasitic inflammatory disease of the bile ducts. Infection occurs through ingestion of fluke-infested, fresh-water raw fish. The most well-known species that cause...Full Text Available

2011-05-01

247

Kidney Function Influences Warfarin Responsiveness and Hemorrhagic Complications  

UK PubMed Central (United Kingdom)

Although management of warfarin is challenging for patients with chronic kidney disease (CKD), no prospective studies have compared response to warfarin among patients with minimal, moderate, and severe...Full Text Available

2009-04-01

248

Is There a Role for Patent Medicine Vendors in Tuberculosis Control in Southern Nigeria?  

UK PubMed Central (United Kingdom)

Patent medicine vendors (PMVs) are a ubiquitous feature of the informal health sector in Nigeria. A previous study on healthcare-seeking behaviour of persons with chronic cough in southern Nigeria found...Full Text Available

2010-12-01

249

Iron Metabolism in the Anaemia of Chronic Renal Failure. Effects of Dialysis and of Pareuteral Iron  

UK PubMed Central (United Kingdom)

Serial studies of iron transport in patients on maintenance dialysis showed normal or raised values in almost all subjects and a transient increase soon after the start of dialysis in three. These...Full Text Available

1969-07-26

250

Intravenous immunoglobulin in the treatment of primary trigeminal neuralgia refractory to carbamazepine: a study protocol[ISRCTN33042138  

UK PubMed Central (United Kingdom)

BackgroundWe have recently reported successful treatment of patients with chronic pain syndromes using human pooled intravenous immunoglobulin (IVIG) in a prospective, open-label...Full Text Available

251

Information Systems for Patient Follow-Up and Chronic Management of HIV and Tuberculosis: A Life-Saving Technology in Resource-Poor Areas  

UK PubMed Central (United Kingdom)

Background The scale-up of treatment for HIV and multidrug-resistant tuberculosis (MDR-TB) in developing countries requires a long-term relationship with the...Full Text Available

252

Image-guided lumbar facet joint infiltration in nonradicular low back pain  

UK PubMed Central (United Kingdom)

Objective:To assess the efficacy of facet joint infiltrations for pain relief in 44 selected patients with chronic nonradicular low back pain (LBP).Materials...Full Text Available

2009-02-01

253

Idiopathic venous thromboembolism and thrombophilia  

UK PubMed Central (United Kingdom)

During the past decade idiopathic venous thromboembolism has become a separate entity, a chronic illness which has required prolonged anticoagulation and other prevention strategies to avoid recurrences....Full Text Available

2011-02-15

254

Hyperbilirubinemia in Inflammatory Pancreatic Disease: Natural History and Management  

UK PubMed Central (United Kingdom)

Of 868 patients admitted with pancreatitis between 1971 and 1976, coexisting hyperbilirubinemia was noted in 125 (14%). The patient population was primarily composed of alcoholics (84%) with chronic...Full Text Available

1978-11-01

255

Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation  

UK PubMed Central (United Kingdom)

Ethnopharmacological relevanceHLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases....Full Text Available

2009-05-04

256

Homeostasis of intrinsic excitability in hippocampal neurones: dynamics and mechanism of the response to chronic depolarization  

UK PubMed Central (United Kingdom)

In order to maintain stable functionality in the face of continually changing input, neurones in the CNS must dynamically modulate their electrical characteristics. It has been hypothesized that in...Full Text Available

2010-01-01

257

Hepatotoxicity of High Oral Dose (-)-Epigallocatechin-3-Gallate in Mice  

UK PubMed Central (United Kingdom)

The tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) has been studied for chronic disease preventive effects, and is marketed as part of many dietary supplements. However, case reports have...Full Text Available

2010-01-01

258

Hepatitis B virus infection and primary hepatocellular carcinoma.  

UK PubMed Central (United Kingdom)

For many years, epidemiological studies have demonstrated a strong link between chronic hepatitis B virus (HBV) infection and the development of primary hepatocellular carcinoma (PHC). Other hepatocarcinogens...Full Text Available

1992-07-01

259

Glycyrrhizin as antiviral agent against Hepatitis C Virus  

UK PubMed Central (United Kingdom)

BackgroundHepatitis C virus is a major cause of chronic liver diseases which can lead to permanent liver damage, hepatocellular carcinoma and death. The presently available treatment...Full Text Available

260

Gene expression profile of rat left ventricles reveals persisting changes following chronic mild exercise protocol: implications for cardioprotection  

UK PubMed Central (United Kingdom)

BackgroundEpidemiological studies showed that physical exercise, specifically moderate lifelong training, is protective against cardiovascular morbidity and mortality. Most experimental...Full Text Available

261

Foraminal stenosis complicating retained broken epidural needle tip -A case report-  

UK PubMed Central (United Kingdom)

Lumbar epidural anesthesia is useful in a variety of chronic benign pain syndromes, including lumbar radiculopathy, low back pain syndrome, spinal stenosis, and vertebral compression fractures. Given...Full Text Available

2010-12-01

262

Food meanings in HIV and AIDS caregiving trajectories: Ritual, optimism and anguish among caregivers in Lesotho  

UK PubMed Central (United Kingdom)

The article describes the caregiving responsibility to provide food for chronically ill family members and the meanings attached to food and eating when ill created stress for family caregivers. The...Full Text Available

2011-02-05

263

Facial osteomyelitis as complication of chronic sinusitis in hemophiliac-AIDS patients - scintigraphic evaluation with technetium-99m-MDP and Gallium-67; Osteomielitis da face como complicacao de sinusite cronica em hemofilicos aideticos - avaliacao cintilografica com {sup 99m} Tc-MDP e {sup 67} Ga  

Energy Technology Data Exchange (ETDEWEB)

In the paper six cases of facial osteomyelitis as a complication of chronic sinusitis in hemophiliac-AIDS patients are reported. Osteomyelitis was suggested by an increasing of erythrocyte sedimentation rate. The diagnosis was confirmed by a positive {sup 99m} Tc MDP scintigraphy. The patients were submitted to clinical treatment. The erythrocyte sedimentation rate and 67-gallium citrate scans were used in the follow-up of the therapy. Three patients had negative gallium after three weeks of organism-specific antibiotic therapy; in two patients the gallium scintigraphy remained positive. One patient did not undergo the radionuclide scan for this clinical conditions. These results suggest that MDP scans showed higher sensitivity and specificity in detection of bone disease in chronic sinusitis. Gallium scans appeared to be valuable tool in the follow-up of the infection. There are no reports in the literature of osteomyelitis as a complication ...

1997-01-01

264

Evaluation of support groups for women with breast cancer: importance of the navigator role  

UK PubMed Central (United Kingdom)

BackgroundAt least some forms of breast cancer are increasingly being viewed as a chronic illness, where an emphasis is placed on meeting the various ongoing needs of people living...Full Text Available

265

Evaluating noncancer effects of trichloroethylene: dosimetry, mode of action, and risk assessment.  

UK PubMed Central (United Kingdom)

Alternatives for developing chronic exposure limits for noncancer effects of trichloroethylene (TCE) were evaluated. These alternatives were organized within a framework for dose-response assessment--exposure:dosimetry...Full Text Available

2000-05-01

266

Elevated c-Src tyrosine kinase activity in premalignant epithelia of ulcerative colitis.  

UK PubMed Central (United Kingdom)

Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with a high incidence of colon cancer. Dysplasia is a precursor to carcinoma and a predictor of malignant potential; epithelia...Full Text Available

1994-02-01

267

Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial  

UK PubMed Central (United Kingdom)

BackgroundObesity has reached epidemic proportions in the United States. It is implicated in the development of a variety of chronic disease states and is associated with increased...Full Text Available

268

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep.  

UK PubMed Central (United Kingdom)

The effects of Escherichia coli endotoxin on lung mechanics, hemodynamics, gas exchange, and lung fluid and solute exchange were studied in 12 chronically instrumented unanesthetized sheep. A possible...Full Text Available

1983-07-01

269

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice  

UK PubMed Central (United Kingdom)

In chronic kidney disease, fibroblast dysfunction causes renal fibrosis and renal anemia. Renal fibrosis is mediated by the accumulation of myofibroblasts, whereas renal anemia is mediated by the reduced...Full Text Available

2011-10-03

270

Diabetes: An Investor's Perspective  

UK PubMed Central (United Kingdom)

Total health care expenditure in 2006 was $2.1 trillion. This figure is estimated to double within the next few years as the cost of treating diabetes and other chronic conditions continues to rise....Full Text Available

271

Development of Korean Academy of Medical Sciences Guideline Rating the Physical Impairment; Kidney, Bladder, Urethra, Male and Female Reproductive Systems (Preliminary Report)  

UK PubMed Central (United Kingdom)

For the evaluation of the kidney impairment, serum creatinine concentrations or glomerular filtration rates are mainly used, and the conditions of solitary or transplanted kidney and chronic dialysis...Full Text Available

2009-05-01

272

Detection of Sub-Clinical CWD Infection in Conventional Test-Negative Deer Long after Oral Exposure to Urine and Feces from CWD+ Deer  

UK PubMed Central (United Kingdom)

BackgroundChronic wasting disease (CWD) of cervids is a prion disease distinguished by high levels of transmissibility, wherein bodily fluids and excretions are thought to play an...Full Text Available

273

Deposition and retention of inhaled fibres: effects on incidence of lung cancer and mesothelioma.  

UK PubMed Central (United Kingdom)

A review of the literature on chronic inhalation studies in which rats were exposed to mineral fibres at known fibre number concentrations was undertaken to examine the specific roles of fibre length...Full Text Available

1994-12-01

274

Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity.  

UK PubMed Central (United Kingdom)

Lymphocytes from patients with insulin-dependent diabetes mellitus (IDDM), a chronic autoimmune disease, have recently been shown to have decreased surface expression of MHC class I antigens. Since...Full Text Available

1993-05-01

275

Cumulative Inflammatory Load Is Associated with Short Leukocyte Telomere Length in the Health, Aging and Body Composition Study  

UK PubMed Central (United Kingdom)

BackgroundLeukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of ...Full Text Available

276

Correlation of Pain Scores, Analgesic Use, and Beck Anxiety Inventory Scores During Hospitalization in Lower Extremity Amputees  

UK PubMed Central (United Kingdom)

Post amputation pain can be debilitating for patients and families. Chronic pain is a common phenomenon after lower extremity amputation, occurring in up to 80% of this population. The purpose of this...Full Text Available

277

Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor ?B Is a Steady Feature of Urinary Bladder Carcinogenesis  

UK PubMed Central (United Kingdom)

Objectives. The inescapable relationship between chronic inflammation and carcinogenesis has long been established. Our objective was to investigate COX-2 and NF-κB...Full Text Available

2010-01-01

278

Consequences of Low Neonatal Iron Status due to Maternal Diabetes Mellitus on Explicit Memory Performance in Childhood  

UK PubMed Central (United Kingdom)

Diabetic pregnancies are characterized by chronic metabolic insults, including iron deficiency, that place the developing brain at risk and for memory impairment later in life. A behavioral...Full Text Available

2009-11-01

279

Concentric Versus Enhanced Eccentric Hamstring Strength Training: Clinical Implications  

UK PubMed Central (United Kingdom)

Objective: Hamstring injuries can be quite debilitating and often result in chronic problems. Eccentric muscle actions are often the last line of defense against muscle injury...Full Text Available

1998-07-01

280

Chronic inflammation and estradiol interact through MAPK activation to affect TMJ nociceptive processing by trigeminal caudalis neurons  

UK PubMed Central (United Kingdom)

The mitogen-activated protein kinase/extracellular regulated kinase (MAPK/ERK) pathway plays a key role in mediating estrogen actions in the brain and neuronal sensitization during inflammation....Full Text Available

2009-12-29

281

Chronic immobilisation stress ameliorates clinical score and neuroinflammation in a MOG-induced EAE in Dark Agouti rats: mechanisms implicated  

UK PubMed Central (United Kingdom)

BackgroundMultiple sclerosis (MS) is the endpoint of a complex and still poorly understood process which results in inflammation, demyelination and axonal and neuronal degeneration....Full Text Available

282

Chronic Coronary Artery Disease: Diagnosis and Management  

UK PubMed Central (United Kingdom)

Coronary artery disease (CAD) is the single most common cause of death in the developed world, responsible for about 1 in every 5 deaths. The morbidity, mortality, and socioeconomic importance...Full Text Available

2009-12-01

283

Chronic Cocaine-Induced H3 Acetylation and Transcriptional Activation of CaMKII? in the Nucleus Accumbens Is Critical for Motivation for Drug Reinforcement  

UK PubMed Central (United Kingdom)

The regulation of gene expression in the brain reward regions is known to contribute to the pathogenesis and persistence of drug addiction. Increasing evidence suggests that the regulation of gene transcription...Full Text Available

2010-03-01

284

Changes in colonic motility induced by sennosides in dogs: evidence of a prostaglandin mediation.  

UK PubMed Central (United Kingdom)

The effects of sennosides on colonic motility were investigated in eight conscious dogs chronically fitted with two strain gauge transducers in the proximal colon, an intracolonic silicone catheter...Full Text Available

1988-09-01

285

Challenge and Hope in Radiotherapy of Hepatocellular Carcinoma  

UK PubMed Central (United Kingdom)

Hepatocellular carcinoma (HCC) is one of the most critical global health issues. With frequent association of viral liver disease, HCC is highly complex, harboring both cancer and chronic liver disease....Full Text Available

2009-10-31

286

CHRONIC ETHANOL FEEDING AFFECTS PROTEASOME INTERACTING PROTEINS  

UK PubMed Central (United Kingdom)

Studies on alcoholic liver injury mechanisms show a significant inhibition of the proteasome activity. To investigate this phenomenon, we isolated proteasome complexes from the liver of rats...Full Text Available

2009-07-01

287

Brucella arthritis: a study of 96 cases in Kuwait.  

UK PubMed Central (United Kingdom)

Of 400 patients with brucellosis, 104 (26%) had arthritis, of whom 96 could be followed up. The systemic disease in the 96 patients was acute in 54 (56%), subacute in 24 (25%), and chronic in 18 (19%)....Full Text Available

1990-12-01

288

Breakdown of the Blood-Brain Barrier during Tick-Borne Encephalitis in Mice Is Not Dependent on CD8+ T-Cells  

UK PubMed Central (United Kingdom)

Tick-borne encephalitis (TBE) virus causes severe encephalitis with serious sequelae in humans. The disease is characterized by fever and debilitating encephalitis that can progress to chronic illness...Full Text Available

289

Bio-remediation of hydrocarbons in coastal regions; Bioremediation des hydrocarbures en milieu cotier  

Energy Technology Data Exchange (ETDEWEB)

Coasts are exposed to chronic or accidental pollutions by hydrocarbons. The aim of this study is to show the importance of the microbial layers (stratified sedimentary systems) in the biodegradation of the hydrocarbons. (A.L.B.)

2001-07-01

290

Autoimmune pancreatitis with atypical imaging findings that mimicked an endocrine tumor  

UK PubMed Central (United Kingdom)

Autoimmune pancreatitis (AIP) is a rare cause of recurrent acute pancreatitis or chronic pancreatitis in middle-aged patients, and is characterised by a marked infiltration of lymphocytes and plasma...Full Text Available

2010-06-21

291

Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers  

UK PubMed Central (United Kingdom)

Recent studies suggest that calcium influx via L-type calcium channels is necessary for psychostimulant-induced behavioral sensitization. In addition, chronic amphetamine upregulates subtype...Full Text Available

2007-07-26

292

Associations between the clinical signs of chronic endometritis with ovarian cysts and body condition loss in German Holstein Friesian cows  

UK PubMed Central (United Kingdom)

The objective of this retrospective field study was to associate the type and smell of discharge, the size of the uterus, the ovarian and treatment status, and the time to diagnosis of animals with...Full Text Available

2009-12-01

293

Arsenic Exposure and Type 2 Diabetes: A Systematic Review of the Experimental and Epidemiologic Evidence  

UK PubMed Central (United Kingdom)

Chronic arsenic exposure has been suggested to contribute to diabetes development. We performed a systematic review of the experimental and epidemiologic evidence on the association of arsenic and type...Full Text Available

2006-05-01

294

Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.  

UK PubMed Central (United Kingdom)

beta-Endorphin-like immunoreactivity in human ventricular cerebrospinal fluid was measured with a specific radioimmunoassay. The subjects were undergoing a surgical procedure for relief of chronic intractable...Full Text Available

1978-10-01

295

Antioxidant Treatment Alters Peripheral Vascular Dysfunction Induced by Postnatal Glucocorticoid Therapy in Rats  

UK PubMed Central (United Kingdom)

BackgroundPostnatal glucocorticoid therapy in premature infants diminishes chronic lung disease, but it also increases the risk of hypertension in adulthood. Since glucocorticoid...Full Text Available

296

Analysis of Failed Spinal Cord Stimulation Trials in the Treatment of Intractable Chronic Pain  

UK PubMed Central (United Kingdom)

ObjectiveThe purpose of this study is to identify the factors affecting the failure of trials (<50% pain reduction in pain for trial period) to improve success rate of spinal...Full Text Available

2008-02-01

297

An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program.  

UK PubMed Central (United Kingdom)

Since the establishment of the National Toxicology Program (NTP), there have been gradual changes in strategies to evaluate the overall toxicity of chemicals as well as their carcinogenic potential....Full Text Available

1990-06-01

298

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction  

UK PubMed Central (United Kingdom)

BackgroundChronic kidney disease and end-stage renal disease are major causes of morbidity and mortality that are seen far more commonly in the aged population. Interestingly, kidney...Full Text Available

299

A cross-sectional study of Tritrichomonas foetus infection among healthy cats at shows in Norway  

UK PubMed Central (United Kingdom)

BackgroundIn recent years, the protozoan Tritrichomonas foetus has been recognised as an important cause of chronic large-bowel diarrhoea in purebred cats in many...Full Text Available

300

?? T cells and Th17 cytokines in Hypersensitivity Pneumonitis and Lung Fibrosis  

UK PubMed Central (United Kingdom)

Hypersensitivity pneumonitis (HP) is an inflammatory lung disease caused by repeated inhalation of aerosolized antigens. With chronic exposure to an inhaled antigen, patients are at risk of...Full Text Available

2009-11-01

301

1996 Hazardous Substances and New Organisms No. 30  

Wastenet

ii) Flammability: (iii) A capacity to oxidise: (iv) Corrosiveness: (v) Toxicity (including chronic ...an explosion or fire: (d) For substances with corrosive properties: (i) To reduce the ...likelihood of any unintended corrosion:(ii) To control the adverse effects of any corrosion:

302

Patient isolation in chronic benign pain.  

Science.gov (United States)

Over the years, nurses, doctors and scientists have sought ways of assessing the impact of pain on patients. While many of the instruments devised have been extremely useful in identifying the nature and intensity of pain, defining the effect it has on people's lives and perceptions has proved much more problematic. Based on the work she carried out with patients suffering from chronic benign pain, Karen Rose explores one aspect of these effects--the feeling of isolation. By using a four-step anthropological approach to identify the impact of pain, she argues, nurses can arrive at a realistic and accurate assessment of how patients are coping. PMID:7947167

303

Botulinum toxin—Beyond wrinkles  

British Library Electronic Table of Contents (United Kingdom)

Botulinum neurotoxin is produced by the bacterium, Clostridium botulinum. The neurotoxin inhibits acetylcholine at the neuromuscular junction, thus interfering with overall muscular contraction. Botulinum neurotoxin is commonly used for the following medical conditions: cervical dystonia, upper limb spasticity, blepharospasm, strabismus, and hyperhydrosis. However, the use of botulinum neurotoxin was recently approved for the prophylaxis of headaches in adults with chronic migraines. The proposed mechanism of botulinum neurotoxin is no longer solely limited to the inhibition of acetylcholine. There are new mechanisms emerging that involve inhibition of proinflammatory agents and neuropeptides involved in chronic pain. Consequently, there is a disruption of the overall sensory feedback loop...

2011-01-01

304

Bilateral lipoma arborescens of the bicipitoradial bursa  

International Nuclear Information System (INIS)

A 37-year-old military mechanic presented to our institution with a chronic history of a slowly enlarging left elbow antecubital fossa mass. There was no history of other chronic illness or trauma. Magnetic resonance imaging (MRI) and excisional biopsy revealed fatty villi and synovial inflammation within the left bicipitoradial bursa, consistent with lipoma arborescens. Four years later the patient presented with a 6-month history of swelling at the antecubital fossa of the opposite elbow. Diagnostic computed tomography and MRI examinations were performed. The surgical and pathologic findings confirmed the imaging diagnosis of lipoma arborescens at the right bicipitoradial bursa. (orig.)

2002-11-01

305

Structural determinants of alpha-bungarotoxin binding to the sequence segment 181-200 of the muscle nicotinic acetylcholine receptor #alpha# subunit: Effects of cysteine/cystine modification and species-specific amino acid substitution  

International Nuclear Information System (INIS)

The sequence segment 181-200 of the Torpedo nicotinic acetylcholine receptor (nAChR) #alpha#subunit forms a binding site for #alpha#-bungarotoxin (#alpha#-BTX). Synthetic peptides corresponding to the homologous sequences of human, calf, mouse, chicken, frog, and cobra muscle nAChR #alpha#1 subunits were tested for their ability to bind "1"2"5I-#alpha#-BTX, and differences in #alpha#-BTX affinity were determined by using solution (IC_5_0s) and solid-phase (K_ds) assays. Panels of overlapping peptides corresponding to the complete #alpha#1 subunit of mouse and human were also tested for #alpha#-BTX binding, but other sequence segments forming the #alpha#-BTX site were not consistently detectable. The role of a putative vicinal disulfide bound between Cys-192 and -193, relative to the Torpedo sequence, was determined by modifying the peptides with sulfhydryl reagents. Reduction and alkylation of the peptides decreased #alpha#-BTX binding, whereas oxidation of the ...

306

Molecular characterization of the Spirometra mansonoides genome: renaturation kinetics, methylation, and hybridization to human cDNA probes.  

Science.gov (United States)

High molecular weight DNA from pleroceroid larvae of the tapeworm Spirometra mansonoides was purified from isolated nuclei by conventional techniques. The DNA so isolated has a melting temperature (Tm) of 87 degrees C and a guanine plus cytosine (G/C) content of 44%. 5-Methyl cytosine could not be detected in plerocercoid DNA by HPLC analysis of DNA hydrolysates, by radiolabeling 5'-termini of MspI digests with polynucleotide kinase, or by comparing restriction patterns generated by MspI and HpaII. Renaturation kinetics demonstrated that the genome of S. mansonoides contains repetitive as well as single copy sequences and has a genome size estimated at approx. 1.6 X 10(9) bp. Hybridization was carried out between plerocercoid DNA and cDNAs for human beta-actin, alpha-tubulin and growth hormone (hGH). Rationale for this analysis was based on known homologies among actin and tubulin genes in numerous species and on apparent similarities between hGH and a plerocercoid growth factor that ...

1990-06-21

307

A pain management program for chronic cancer-treatment-related pain: a preliminary study.  

Science.gov (United States)

A large proportion of patients may develop chronic pain following cancer treatments such as surgery, radiotherapy, or chemotherapy. These patients can experience significant levels of physical and psychological morbidity. Our aim was to investigate a cognitive-behavioral pain management program (PMP) for cancer patients with chronic treatment-related pain. Thirteen patients (1 man, 12 women; mean age 52 yrs) completed the study, 9 of whom had a history of breast cancer and had received extensive medical treatment, including surgery. A combination of physical and psychological techniques were adapted from previous work in chronic benign pain and implemented by two therapists. Interventions included education, relaxation, exercise training, and goal setting. A variety of outcomes were examined to assess general fitness, psychological distress, coping success, activities of daily living, and pain report. The median number of ...

2006-02-01

308

Percolation-theory and fuzzy rule-based probability estimation of fault leakage at geologic carbon sequestration sites  

Energy Technology Data Exchange (ETDEWEB)

Leakage of CO{sub 2} and displaced brine from geologic carbon sequestration (GCS) sites into potable groundwater or to the near-surface environment is a primary concern for safety and effectiveness of GCS. The focus of this study is on the estimation of the probability of CO{sub 2} leakage along conduits such as faults and fractures. This probability is controlled by (1) the probability that the CO{sub 2} plume encounters a conductive fault that could serve as a conduit for CO{sub 2} to leak through the sealing formation, and (2) the probability that the conductive fault(s) intersected by the CO{sub 2} plume are connected to other conductive faults in such a way that a connected flow path is formed to allow CO{sub 2} to leak to environmental resources that may be impacted by leakage. This work is designed to fit into the certification framework for geological CO{sub 2} storage, which represents vulnerable resources such as potable groundwater, health and safety, and the near-surface ...

2009-05-01

309

Thyroid Cathepsin K: Roles in Physiology and Thyroid Disease  

British Library Electronic Table of Contents (United Kingdom)

The human genome encodes 11 cysteine cathepsins belonging to the papain-like family of cysteine peptidases that are known predominantly as endo-lysosomal enzymes. However, it is now understood that the functions and activities of cysteine cathepsins are not limited to endo-lysosomal compartments, as they are also active in the peri- and extracellular space. The thyroid gland is an endocrine organ where such intra- and extracellular proteolytic activities are required to solubilize the prohormone thyroglobulin from its luminal, covalently cross-linked storage forms for subsequent processing into smaller protein fragments and thyroid hormone liberation. Cathepsin K has been identified as one of the cysteine cathepsins with a crucial role in thyroglobulin processing. However, cathepsin K has ...

2011-01-01

310

Review and investigations of oscillatory flow behaviour of a horizontal ceiling opening for nuclear containment and fire safety analysis  

Energy Technology Data Exchange (ETDEWEB)

In the thermal hydraulics codes developed for fire safety analysis and for containment thermal hydraulic analysis, junctions in the multi-compartment geometries is often modeled as uni-directional junctions. However, ceiling junctions are known to depict unstable/oscillatory bi-directional flow behavior. Detailed investigations have been carried out to understand the unstable flow behaviour of a junction by analyzing an earlier reported experiment and its subsequent two dimensional numerical RANS based study of fire in an enclosure. The authors attempt more realistic and desired three dimensional and inherently transient large eddy simulations using a computer code Fire Dynamics Simulator (FDS). The paper presents the details of the analysis, the results obtained and further studies required to be conducted so that the findings can be applied to the fire/containment thermal hydraulics analysis codes successfully. (orig.)

2011-05-15

311

Locally D-optimal designs based on a class of composed models resulted from blending Emax and one-compartment models  

CERN Document Server

A class of nonlinear models combining a pharmacokinetic compartmental model and a pharmacodynamic Emax model is introduced. The locally D-optimal (LD) design for a four-parameter composed model is found to be a saturated four-point uniform LD design with the two boundary points of the design space in the LD design support. For a five-parameter composed model, a sufficient condition for the LD design to require the minimum number of sampling time points is derived. Robust LD designs are also investigated for both models. It is found that an LD design with $k$ parameters is equivalent to an LD design with $k-1$ parameters if the linear parameter in the two composed models is a nuisance parameter. Assorted examples of LD designs are presented.

2008-01-01

312

Integral air-conditioning system for electric cars. Integrales Klimasystem fuer Elektroautomobile  

Energy Technology Data Exchange (ETDEWEB)

Increasing environmental awareness and new legislation in Europe and, in particular, America have accelerated the development of marketable electric cars which satisfy customer demands in terms of performance, range capability, safety and comfort. Tomorrow's electric cars will therefore require powerful heating and cooling systems for the passenger compartment which meet the conditions specific to this particular mode of transport and which do not overly affect the range capability of such vehicles. At Behr GmbH suitable system concepts were developed at a very early stage which were based on a high proportion of recirculated air, the use of the A/C unit as a heat pump, and heat recovery. This paper will examine two typical A/C systems which combine good heating and cooling characteristics with the low electric power requirement of only 1,5-2 kW. (orig.).

1992-11-01

313

In vivo distribution and excretion studies and in vitro blood studies on the kinetics of lead-203 in beagle dogs  

International Nuclear Information System (INIS)

Studies on the kinetics of the distribution of lead-203 in body fluids have been carried out in vitro, and in animal studies using beagle dogs. In vitro, the distribution of carrier free lead-203 between plasma and cells of canine blood at 37"0C was measured after the addition of isotope. In animal studies, activity in plasma was measured for about 150 hours, and activity in blood cells, urine and feces measured for about 400 hours after exposure to lead-203. Linear compartmental models for distribution of the isotope are presented for both in vitro and in vivo experimental systems. The models contain compartments for both untransformed lead, for isotope added in saline or citric acid, and transformed lead, as obtained by lead-203 incubation in plasma.

314

Improved recovery demonstration for Williston basin carbonates. Quarterly technical progress report, October 1, 1995--December 31, 1995  

Science.gov (United States)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in-place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing 3-dimensional and multi-component seismic area is being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with extended-reach jetting lance and other ultra-short radius lateral technologies. Improved completion efficiency, additional wells at closer spacing and better estimates of oil-in-place will result in additional oil production by primary and enhanced recovery processes.

1996-02-01

315

Improved recovery demonstration for Williston basin carbonates. Annual report, June 10, 1994--June 9, 1995  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in-place, methods for improved completion efficiency and the suitability of waterflooding in Red River and Ratcliffe shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing three-dimensional and multi-component seismic are being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with extended-reach jetting lance and other ultra-short-radius lateral technologies. Improved completion efficiency, additional wells at closer spacing and better estimates of oil in place will result in additional oil recovery by primary and enhanced recovery processes.

1995-09-01

316

Improved recovery demonstration for Williston Basin carbonates. Quarterly technical progress report, October--December 1996  

Science.gov (United States)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in-place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing 3-dimensional (3D) and multi-component seismic are being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with short-lateral and horizontal drilling technologies. Improved completion efficiency, additional wells at closer spacing and better estimates of oil-in-place will result in additional oil production by primary and enhanced recovery processes.

1997-04-01

317

Improved recovery demonstration for Williston Basin carbonates. Quarterly report, July 1 - September 30, 1996  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in- place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing 3-dimensional (3D) and multi-component seismic are being investigated for identification of structural and stratigraphic reservoir compartments. Field demonstrations are in progress to collect data for evaluation of horizontal completions in both the Red River and Ratcliffe. A vertical well in the Red River will test attribute analysis of 3D seismic data for prediction of porosity development. Additional seismic acquisitions and interpretation are in progress for both the Ratcliffe and Red River. A water-injectivity test in a new horizontal completion in the Red Rive B zone at Buffalo Field is ...

1996-12-31

318

Improved recovery demonstration for Williston Basin carbonates. Annual report, June 10, 1995--June 9, 1996  

Science.gov (United States)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in-place, methods for improved completion efficiency and the suitability of waterflooding in Red River and Ratcliffe shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing three-dimensional and multi-component seismic are being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with extended-reach jetting lance and other ultra-short-radius lateral technologies. Improved completion efficiency, additional wells at closer spacing and better estimates of oil in place will result in additional oil recovery by primary and enhanced recovery processes.

1996-09-01

319

Improved recovery demonstration for Williston Basin carbonates  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in- place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing 3-dimensional (3D) and multi- component seismic are being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with short- lateral and horizontal drilling technologies. Improved completion efficiency, additional wells at closer spacing and better estimates of oil-in-place will result in additional oil production by primary and enhanced recovery processes.

1996-09-01

320

Improved recovery demonstration for Williston Basin carbonates  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determination of oil-in-place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing 3-dimensional (3D) is being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with short lateral and horizontal drilling technologies. Improved completion efficiency, additional wells at closer spacing and better estimates of oil-in- place will result in additional oil production by primary and enhanced recovery processes.

1997-12-01

321

Improved Recovery Demonstration for Williston Basin Carbonates.  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in- place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing 3-dimensional (3-D) and multi-component seismic are being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with short-lateral and horizontal drilling technologies. Improved completion efficiency, additional wells at closer spacing and better estimate of oil-in-place will result in additional oil production by primary and enhanced recovery processes.

1997-12-31

322

Improved Recovery Demonstration for Williston Basin Carbonates  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in- place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing 3-dimensional (3-D) and multi- component seismic are being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with short- lateral and horizontal drilling technologies. Improved completion efficiency, additional wells at closer spacing and better estimate of oil-in-place will result in additional oil production by primary and enhanced recovery processes.

1997-03-01

323

Improved Recovery Demonstration for Williston Basin Carbonates  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in-place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing three-dimensional is being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with short-lateral and horizontal drilling technologies. Improved completion efficiency, additional wells at closer spacing and better estimates of oil-in-place will result in additional oil production by primary and enhanced recovery processes.

1997-12-31

324

Immunofluorescence analysis of the internal brain anatomy of Nereis diversicolor (Polychaeta, Annelida)  

British Library Electronic Table of Contents (United Kingdom)

Comparative analyses of neuroanatomical characters can make valuable contributions to the inference of phylogenetic relationships. Whereas investigations in this field are numerous for arthropods, in-depth studies on other protostomes are sparse. Here, we provide a survey of the internal neuroarchitecture of the brain of the aciculate ragworm Nereis diversicolor (Polychaeta, Annelida). Descriptions are based on confocal laser scanning microscope analyses of brain sections labeled with the nuclear marker DAPI and antibodies raised against FMRF-amide, serotonin, and histamine. Autofluorescence of the nervous tissue has been utilized to further elucidate the anatomical structures of the brain. The architecture of two major brain compartments, i.e., the paired mushroom bodies and the central o...

2008-01-01

325

Greater than the sum of their parts: Combination strategies for immune regeneration following allogeneic hematopoietic stem cell transplantation  

British Library Electronic Table of Contents (United Kingdom)

Cytoreductive conditioning regimes designed to allow for successful allogeneic hematopoietic stem cell transplantation (allo-HSCT) paradoxically are also detrimental to recovery of the immune system in general but lymphopoiesis in particular. Post-transplant immune depletion is particularly striking within the T cell compartment which is exquisitely sensitive to negative regulation, evidenced by the profound decline in thymic function with age. As a consequence, regeneration of the immune system remains a significant unmet clinical need. Over the past decade studies have revealed several promising therapeutic strategies to address ineffective lymphopoiesis and post-transplant immune deficiency. These include the use of cytokines such as IL-7, IL-12 and IL-15; growth factors and hormones li...

2011-01-01

326

Functionally defined substates within the human embryonic stem cell compartment.  

Science.gov (United States)

Human embryonic stem (ES) cells can undergo spontaneously differentiation in standard culture conditions, demonstrating that the undifferentiated state is relatively unstable. The heterogeneous expression of SSEA3 observed within human ES colonies, provides a means to examine undifferentiated stem cell substates. Through functional testing of single cells we have shown that undifferentiated ES cells can be segregated into functionally discrete subpopulations on the basis of SSEA3 expression: SSEA3(High), SSEA(Low) and SSEA3(Negative). Human ES subpopulations were found to be interconvertible, but they possess distinct properties when challenged to differentiate along the neural lineage. These data suggest that ES cells with pluripotent/self-renewal capacities can exhibit different responses to induction of differentiation. PMID:21763622

2011-05-11

327

Environmental quality assessment in estuarine ecosystems: Use of biometric measurements and fecundity of the ragworm Nereis diversicolor (Polychaeta, Nereididae)  

British Library Electronic Table of Contents (United Kingdom)

The ability to cope with environmental stress may be expensive in terms of energy and this cost of tolerance is suspected to have negative counterparts such as reduced growth and fecundity. To date, condition indices based on biometric measurements are currently used in bivalves or fish but do not exist in endobenthic worms, despite their interest as bioindicators for the sedimentary compartment in which the major part of pollutants is stored in aquatic environments. In the present work, several biometric variables (jaw and total body length, number of segments, the length of the first three segments L3, wet or dry weight) were measured in the ragworm Nereis diversicolor originating from clean (Authie) and polluted (Seine) estuaries (France) to study size-weight relationships. The producti...

2008-01-01

328

Desorption of b-carotene from mesoporous carbon coated monolith: Isotherm, kinetics and regeneration studies  

British Library Electronic Table of Contents (United Kingdom)

b-carotene, a natural antioxidant, beneficial form human health prospective. In this study we had examined the recovery of b-carotene form mesoporous carbon coated monolith (MCCM) by batch process. Desorption kinetics and isotherm studies were carried out by using n-hexane as an eluent. Isotherm studies showed better applicability of Langmuir model. The first-order two-compartment three-parameter kinetics model as a function of initial loading concentration and reaction temperature was applied. It was observed that b-carotene desorption process is controlled by both rapid and slow desorption. Results showed that the slow desorption fraction increases from 0.8446 to 0.9007 with increase in initial loading concentration from 10.83 to 39.72mg/g while, the slow desorption fraction decreases fr...

2011-01-01

329

CT findings of malignant lymphoma of the anterior mediastinum. Differentiation from invasive thymoma  

Energy Technology Data Exchange (ETDEWEB)

CT findings were compared retrospectively between 9 cases with malignant lymphoma of the anterior mediastinum and 8 cases with invasive thymoma. CT findings of malignant lymphoma were as follows: (1) The majority of the tumors were bilateral and extended beyond the anterior mediastinum to the other mediastinum compartments. (2) Their margin was either smooth or lobulated. (3) Their density was either homogeneous or heterogeneous. In the case with heterogeneous density, ring, triangle and/or band-like low density areas, just like interspace of fused lymph nodes, were demonstrated. Calcification or cysts could not be shown. (4) Patent inherent vessels without deviation were occasionally demonstrated running through the tumors. (5) The tumors faced and contacted widely to anterior chest wall and often pressed the lung laterally at the anterior parietomediastinal pleural reflection. (6) Pleural implants were not demonstrated. (author).

1989-04-01

330

MRI in preoperative evaluation of chronic paranasal sinusitis - a comparison with CT  

International Nuclear Information System (INIS)

Purpose: To determine the value of MRI in the preoperative evaluation of chronic paranasal sinusitis and to compare the results with CT and intraoperative findings. Method/Materials: 42 patients with clinical signs of chronic paranasal sinusitis underwent MRI after CT evaluation on one day, with subsequent functional endoscopic sinus surgery on the next day. Coronary CT was obtained with 5-mm slices and table-feed in the prone position, while MRI was performed in the supine position with coronary T_2-TSE+pd and coronary and transverse HASTE, each with 5-mm slice thickness. Aquisition time in MRI was less than 8 minutes. Two radiologists reviewed the CT and MRI scans for signs of sinusitis and detection of anatomical landmarks. The results were correlated with the intraoperative findings. Results: MRI offered no artifacts of dental work and showed more often high quality pictures than CT. CT and MRI demonstrated a good correlation in the ...

2001-04-01

331

Increase in phorbol ester binding in liver microsomes after chronic administration of phenobarbital  

Energy Technology Data Exchange (ETDEWEB)

The effect of chronic administration of phenobarbital on the binding of phorbol-12,13-dibutyrate (({sup 3}H)PDBu), an activator of protein kinase C (PKC), was examined in rat liver microsomes. A significant increase in the number of binding sites was observed in microsomes of Fisher 344 rats. However, no change appeared in liver cytosol binding of PDBu. Consequently, a translocation process of PKC is unlikely. The increase in ({sup 3}H)PDBu binding in liver microsomes is significant 24 h. after one injection of phenobarbital and reaches its maximum in 2 days. In other strains of rats (ACI and lean Zucker), significant differences were found in the increase of ({sup 3}H)PDBu binding in microsomes. Fisher 344 were the most sensitive, lean Zucker rats, the least sensitive. Those results parallel the pentoxy-resorufin O demethylase activity in the microsomes of the same animals. EC{sub 50} values for inhibition of ({sup 3}H)PDBu binding by pentobarbital were determined ...

1991-03-15

332

Hemodynamic characterization of chronic bile duct-ligated rats: effect of pentobarbital sodium  

International Nuclear Information System (INIS)

Systemic and splanchnic hemodynamics of the chronic bile duct-ligated rat were characterized by radioactive microspheres. Conscious and pentobarbital sodium-anesthetized, bile duct-ligated and sham-operated rats had cardiac output and regional organ blood flows determined. The conscious bile duct-ligated rat compared with the sham-operated showed a hyperdynamic circulation with an increased cardiac output and portal tributary blood flow. Pentobarbital sodium anesthesia induced marked hemodynamic changes in both sham-operated and bile duct-ligated rats. The latter group was especially sensitive to its effects; thus, comparison of cardiac output and portal tributary blood flow between anesthetized bile duct-ligated and sham-operated rats showed no significant differences. The authors conclude that the rat with cirrhosis due to chronic bile duct ligation is an excellent model for hemodynamic investigations but should be studied in the conscious ...

333

Changes in myocardial beta1-adrenergic receptor and stimulatory G-protein gene expression after chronic treatment with doxorubicin in rat.  

Science.gov (United States)

The gene expression of beta(1)-adrenergic receptor (beta(1)AR) and stimulatory G-protein Gsalpha in ventricle after chronic treatment with doxorubicin (DOX) in rat was investigated. The rats were treated with DOX in a dose of 2.5 mg/kg once a week for 5 weeks, the cumulative dose being 12.5 mg/kg. Two weeks after the last injection, the positive inotropic effect of isoproterenol was noticeably decreased in left atrial muscle preparations isolated from DOX-treated rats. Northern blot hybridization showed that the mRNA transcripts of beta(1)AR and Gsalpha, important signal transduction elements for regulating heart rate and contractility, were significantly decreased in the ventricle of DOX-treated rats. Thus, chronic treatment with DOX decreases the gene expression levels of myocardial beta(1)AR and Gsalpha. PMID:15353854

2004-08-01

334

DNA cleavage on photoexposure at the d-d band in ternary copper(II) complexes using red-light laser.  

Science.gov (United States)

Ternary copper(II) complexes [Cu(L1)B](ClO4) (1, 2) and [Cu(L2)B](ClO4) (3, 4), where HL1 and HL2 are tridentate NSO- and ONO-donor Schiff bases and B is a heterocyclic base, viz. dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 1 and 3) or dipyrido[3,2-a:2',3'-c]phenazine (dppz, 2 and 4), were prepared and their DNA binding and photoinduced DNA cleavage activity studied. Complex 1, structurally characterized by single-crystal X-ray crystallography, shows an axially elongated square-pyramidal (4 + 1) coordination geometry in which the monoanionic L1 binds at the equatorial plane. The NN-donor dpq ligand exhibits an axial-equatorial binding mode. The complexes display good binding propensity to calf thymus DNA, giving a relative order 2 (NSO-dppz) > 4 (ONO-dppz) > 1 (NSO-dpq) > 3 (ONO-dpq). They cleave supercoiled pUC19 DNA to its nicked circular form when treated with 3-mercaptopropionic acid (MPA) by formation of hydroxyl radicals as the cleavage active species ...

2006-12-25

335

[Functional state of the hypothalamo-hypophyseal-gonadal system in patients with chronic alcoholic intoxication].  

Science.gov (United States)

The function of the hypothalamo-pituitary-gonadal system has been studied in 118 males with different stages of alcoholism. Comparison with the control group has shown decreased levels of interstitial cell stimulating hormone (ICSH), follicle-stimulating hormone (FSH), and testosterone, and elevated concentrations of prolactin (Prl). Differences in the parameters of hormonal activity expressed in a varying degree of a decrease in FSH, ICSH, and testosterone, and a Prl elevation are related to change in mutual regulatory influences between the gonads and hypothalamo-pituitary complex. The most informative parameters were concentrations of Prl and testosterone (considering elevation in the former and reduction in the latter hormone) and the ratio of their concentrations. Difference of these parameters in each group (corresponding to the stages of alcoholism) may be used as an additional diagnostic criterion of chronic alcohol intoxication. PMID:3434080

1987-01-01

336

Reliability and validity of the PedsQL? Multidimensional Fatigue Scale in Japan  

British Library Electronic Table of Contents (United Kingdom)

Purpose To examine the reliability and validity of the Japanese-language version of the PedsQL? Multidimensional Fatigue Scale and to investigate the agreement between child self-reported fatigue and parent proxy-reported fatigue. Methods The Japanese-language version of the PedsQL? Multidimensional Fatigue Scale was administered to 652 preschoolers and schoolchildren aged 5?12 and their parents, and to 91 parents of preschool children aged 1?4. Results Internal consistency reliability was 0.62?0.87 for children and 0.81?0.93 for parents. Known-group validity was examined between a group of healthy samples (n?=?530) and chronic condition sample (n?=?102); the chronically ill group reported a significantly higher perceived fatigue problem. Correlations between child self- and parent proxy r...

2011-01-01

337

Pyridostigmine interaction with soman during chronic exposure in rodents. Interim report, February-November 1987  

Energy Technology Data Exchange (ETDEWEB)

The effects of repeated low-level nerve agent exposure on animal performance and lethality are a major concern of USAF Medical Research. This concern has generated interest in the role that pretreatment drugs such as pyridostigmine may play during simultaneous exposure to soman. This role was investigated by recording lethality, weights, symptoms, and cholinesterase (ChE) inhibition in rats chronically exposed to 4 levels of soman (32, 39, 48 or 59 micrograms/kg/day) while simultaneously receiving 10.0 milligrams/kg/day pyridostigmine, 1.0 milligrams/kg/day pyridostigmine, or vehicle via an osmotic pump. No effect (either protective or detractive) was found in the soman-poisoned animals due to the presence or absence of pyridostigmine. However, rat blood biochemistry is different from that of the primate, warranting further study in the primate before extrapolation to man.

1988-01-01

338

Psychological distress and investment in one-s appearance in patients with pemphigus  

British Library Electronic Table of Contents (United Kingdom)

Abstract Background- Pemphigus vulgaris is a chronic disease not currently curable. Physical involvement and the impact of chronic therapies can lead patients to changes in psychological and relational areas. Objectives- To provide a measure of psychological distress, dysfunctional investment in one's appearance, and their relationship. Methods- Self-administered questionnaires (ASI, HADS) were given to 74 pemphigus inpatients. Results- Strong associations between psychological distress and dysfunctional investment in one's appearance were observed [adjusted odds ratio (OR) = 7.36, 95% confidence intervals (CI) 1.20-45.11; OR 5.38, 95% CI 0.81-35.87, respectively, for appearance stereotyping and body-image vulnerability], together with a perceived high disease severity (OR 6.03, 95% CI 1.9...

2011-01-01

339

PREVENTION OF INFECTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE PART III: SURVEILLANCE AND AUDITING IN A RENAL CARE ENVIRONMENT  

British Library Electronic Table of Contents (United Kingdom)

Summary This third paper, in a three-part CE series on the preventions of infection in patients with chronic kidney disease, focuses on surveillance and auditing of healthcare-associated infections within the renal care environment. The last decade has seen an increased awareness of the threat to patient safety from healthcare-associated infection (HCAI) and the emergence of multi-drug resistance organisms. Effective HCAI prevention strategies include adequate governance structures, access to expert advice, adherence to standard and transmission-based precautions, minimising the use of invasive medical devices, and surveillance. Surveillance data can be collected using outcome (e.g. infection) and/or process (e.g. hand hygiene compliance audit) measures. Establishing a surveillance program...

2011-01-01

340

No detectable XMRV in subjects with chronic fatigue syndrome from Quebec  

British Library Electronic Table of Contents (United Kingdom)

We investigated the presence of XMRV in a cohort of Quebec patients with chronic fatigue syndrome (CFS). DNA was purified from activated peripheral blood mononuclear cells (PBMCs) and PCR was used to detect XMRV gag and env in 72 patients. Anti-XMRV antibodies were searched in sera of 62 patients by Western blot analysis. Attempts to detect XMRV antigens was made, using immunofluorescence with Gag anti-p30 antiserum on activated PBMC from 50 patients. Plasma viremia was measured by RT-PCR on 9 subjects. Finally, detection of infectious virus in 113 CFS subjects was made by co-culture of PHA+IL-2 activated PBMC with human LNCaP carcinoma cells, and by infecting the same susceptible cells with plasma, using a reverse transcriptase (RT) assay as a readout in both experiments. No detection of ...

2011-01-01

341

Hepatocellular Carcinoma (HCC)  

Science.gov (United States)

Hepatocellular carcinoma (HCC) is considered to be one of the most common malignancies worldwide, and the most common one in Africa and Asia. Over the last decade, a rising incidence of up to 10-15/100,000 per population has been seen in the Western world, with an estimate of 250,000 deaths and more than a million worldwide per year. By the year 2010, the World Health Organization expects that HCC will be the leading cause of cancer mortality surpassing lung cancer. This increasing incidence is most likely related to an increasing prevalence of chronic hepatitis C (HC) and B (HB) virus infections and other diseases inducing chronic inflammation (Befeler and Di Bisceglie 2002; Llovet et al. 2003).

2006-01-01

342

Diesel exhaust inhalation induces heat shock protein 70 expression in vivo  

British Library Electronic Table of Contents (United Kingdom)

Exposure to urban air pollution is an independent risk factor for increased cardiovascular diseases. Heat shock protein 70 (HSP70) has been implicated in the pathogenesis of vascular dysfunction and cardiovascular diseases. This study has been designed to determine whether inhalation of urban air induces HSP70 expression in the lung and blood as well as the association of HSP70 and air pollution-induced vascular dysfunction. Apolipoprotein E (Apo-E) deficient mice were exposed to diesel exhaust (DE) either acutely (3 days, 200 or 400 g/m3 for 6 h/day) or chronically (7 weeks, 200 or 400 g/m3 for 6 h/day). HSP70 was measured in the lung using immunohistochemistry, and in the plasma by ELISA. Abdominal aorta rings were used to determine vascular functional responses. Chronic DE-exposure incr...

2011-01-01

343

Detecting retroviral sequences in chronic fatigue syndrome.  

Science.gov (United States)

XMRV or xenotropic murine leukemia virus-related retrovirus, a recently discovered retrovirus, has been linked to both prostate cancer and chronic fatigue syndrome (CFS). Recently, the teams of Drs. Shyh-Ching Lo and Harvey Alter discovered the presence of sequences closely related to XMRV in the blood of 86.5% of patients with CFS [1]. These findings are important because since the initial discovery of XMRV in CFS, several studies have failed to find XMRV in specimens collected from CFS patients. While the current study also did not find XMRV in CFS, Lo et al. did detect sequences that belong to polytropic mouse endogenous retroviruses (PMV), which share considerable similarity with XMRV. Criteria for future studies that will help bring greater clarity to the issue of retroviral sequences in CFS are proposed below. PMID:21994623

2010-11-03

344

Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE)  

British Library Electronic Table of Contents (United Kingdom)

Objective Multiple sclerosis (MS) and its animal counterpart experimental autoimmune encephalomyelitis (EAE) have a major inflammatory component that drives and orchestrates both diseases. One particular group of mediators are the prostaglandins (PGs), which we have previously shown, through quantitation and pharmacological intervention, to be closely involved in the pathology of MS and EAE. The aim of the current study was to determine the expression of the PG-generating cyclooxygenase (COX) enzymes and the profile of PGE2 and PGD2, in selected central nervous system (CNS) tissues, with the development of the chronic relapsing (CR) form of EAE. In particular, the work investigates the possible relationship between the expression of COX isoenzymes and PG levels during the neurological phas...

2011-01-01

345

Chronic sympathetic activation promotes downregulation of ?-adrenoceptor-mediated effects in the guinea pig heart independently of structural remodeling and systolic dysfunction  

British Library Electronic Table of Contents (United Kingdom)

It is uncertain if downregulation of ?-adrenoceptor signaling pathway is promoted by an enhanced adrenergic tone at an early stage of cardiac disease, or it develops secondary to detrimental local myocardial changes in advanced heart failure. We examined the integrity of ?-adrenoceptor signaling pathway upon chronic infusion of isoproterenol, a ?-adrenoceptor agonist, at a dose producing no structural left ventricular (LV) remodeling and systolic dysfunction. Subcutaneous isoproterenol infusion (400??g?kg?1?h?1 over 16?days) to guinea pigs using osmotic minipumps produced no change in cardiac weights, LV internal dimensions, myocyte cross-sectional area, extent of interstitial fibrosis, and basal contractile function. Isolated, perfused heart preparations from isoproterenol-treated guinea ...

2011-01-01

346

Chronic irradiation and brain development. Final (4th) progress report  

International Nuclear Information System (INIS)

The possible long term effects of chronic radiation exposure have been studied. Rats were given tritiated drinking water (3#mu#Ci/ml) before pregnancy, during pregnancy and threafter, continuously through 5 generations. The brains were studied at 30 and 120 days postnatally. Significant decreases in weight, DNA and protein contents of specific parts of the brain were found, the most pronounced decreases being in the diencephalon. The decreases in protein content were more pronounced than the decreases in DNA content; the decreases were also more pronounced at 30 days than at 120 days, and more pronounced in the fifth generation than in previous generations. An attempt was made to explain these complex phenomena on the basis of known periods of proliferation of various brain cells, damage to mothers themselves in each generation, and damage and repair of nucleic acids caused by radioactivity.

347

Chronic inflammation and mortality in haemodialysis: effect of different renal replacement therapies. Results from the RISCAVID study  

British Library Electronic Table of Contents (United Kingdom)

Background. The `RISchio CArdiovascolare nei pazienti afferenti all' Area Vasta In Dialisi (RISCAVID) study is an observational and prospective trial including the whole chronic haemodialysis (HD) population in the northwest part of Tuscany (1.235 million people). The aim of the study was to elucidate the relevance of traditional and non-traditional risk factors of mortality and morbidity in HD patients as well as the impact of different HD modalities.Methods. A total of 757 HD patients (mean age 66 +- 14 years, mean dialytic age 70 +- 76 months, diabetes 19%) were prospectively followed up for 30 months and all-cause mortality, cardiovascular (CV) mortality and non-fatal CV events (acute myocardial infarction and stroke) were registered. At the time of the enrolment, demographic, clinical...

2008-01-01

348

Analysis of cerebrospinal fluid from chronic fatigue syndrome patients for multiple human ubiquitous viruses and xenotropic murine leukemia-related virus  

British Library Electronic Table of Contents (United Kingdom)

Abstract Recent reports showed many patients with chronic fatigue syndrome (CFS) harbor a retrovirus, xenotropic murine leukemia-related virus (XMRV), in blood; other studies could not replicate this finding. A useful next step would be to examine cerebrospinal fluid, because in some patients CFS is thought to be a brain disorder. Finding a microbe in the central nervous system would have greater significance than in blood because of the integrity of the blood-brain barrier. We examined cerebrospinal fluid from 43 CFS patients using polymerase chain reaction techniques, but did not find XMRV or multiple other common viruses, suggesting that exploration of other causes or pathogenetic mechanisms is warranted. Ann Neurol 2011;

2011-01-01

349

Triphenylmethylphosphonium cation distribution as a measure of hormone-induced alterations in white adipocyte membrane potential  

Energy Technology Data Exchange (ETDEWEB)

Triphenylmethylphosphonium (TPMP+) partitions into the mitochondrial and cytosolic compartments in the rat white adipocyte in a potential-dependent fashion. The relationship between (/sup 3/H)TPMP+ distribution, intracellular cAMP generation and lipolysis in response to hormones and cAMP-mimetic compounds was examined. Half-maximal (/sup 3/H)TPMP+ efflux and glycerol release were produced by 15 and 9 nM adrenocorticotropin, 170 and 110 nM 1-epinephrine, 70 and 27 microM isobutylmethylxanthine and 800 and 750 microM dibutyryl cAMP, respectively. Hormone-stimulated cAMP generation was also correlated with (/sup 3/H)TPMP+ efflux and lipolysis in terms of concentration dependency. In kinetic experiments, glycerol release and (/sup 3/H)TPMP+ efflux in response to adrenocorticotropin or cholera toxin proceeded over a similar time course, whereas an earlier rise in cAMP generation was detected. The depolarizing effect of lipolytic compounds was localized to the ...

1982-01-01

350

Preparation of uranium (IV) from uranium (VI) by using an electrodialysis technique  

International Nuclear Information System (INIS)

Preparation of a uranous nitrate solution from the reduction process of a uranyl nitrate solution by using electrodialysis technique with a cation exchange membrane has been studied. Uranyl ions were reduced into uranous ions in a nitric acid solution stabilized by hydrazine sulfate in a two-compartment electrolytic cell made from flexiglass. Platinum and carbon or stainless steel were used as anode and cathode, respectively. The electrodialysis process was carried out at room temperature. A piece of cation exchange membrane was inserted between the two compartments and the distance between electrode and membrane was 1.5 cm and this was kept constant throughout the experiment. A 100 ml of a nitric acid 1.4 M solution was in the anode chamber as analyte, whilst a 100 ml of a uranyl nitrate solution with the uranium concentration of 23.97 g/l was in the cathode chamber containing hydrazine sulfate. The parameters tasted were reduction voltage, ...

2000-03-08

351

Growth-related variations in the glycosaminoglycan synthesis of ultraviolet light-induced murine cutaneous fibrosarcoma cells  

Energy Technology Data Exchange (ETDEWEB)

Glycosaminoglycan synthesis was studied in cell populations of ultraviolet light-induced murine cutaneous fibrosarcoma cells under conditions of varying growth rates in vitro. After labeling with the precursors, /sup 3/H-glucosamine and /sup 35/SO/sub 4/, sulfated glycosaminoglycans recoverable by direct proteolysis of the culture monolayers increased approximately 5-fold on a per cell basis from sparsely populated, exponential cell cultures (greater than 85% of cells in S, G2, or M phases) to stationary cultures inhibited by high cell density (greater than 50% of cells in G1). Within this cell surface-associated material, the relative ratio of heparan sulfate to the chondroitin sulfates was approximately 60/40% under conditions of exponential growth; in the growth-arrested cultures, the reverse ratio was found. The substratum attached material, obtained from the flask surface after ethyl glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid (EGTA)-mediated detachment of the ...

1985-08-01

352

Elemental transfer from Chinese soil via the diet to the whole human body  

International Nuclear Information System (INIS)

Based on results from recent studies of elemental dietary intake and organ or tissue content for adult Chinese men, quoted nationwide elemental concentrations in Chinese soil and newly published national average consumption of dietary foods, values of both transfer coefficients and discrimination factor (DF) for transfer from soil via the diet to both critical organs and the whole body have been calculated for important elements in radiation protection, including alkaline earths, alkali metals, rare earths and other related elements. These calculations have used both the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) model and the DF method. In the UNSCEAR model, the basic parameters used to describe the transport of radionuclides are the transfer coefficients P_i_j, which describe the relationship of concentrations or other amounts between compartment i and the following compartment j, whereas the DF is the ...

2008-12-01

353

[Hormonal disorders in chronic alcoholic intoxication].  

Science.gov (United States)

Hormone levels were examined in the venous blood in 54 men suffering from stage 2 alcoholism and in 30 normal subjects, using a radioimmunochemical assay. The alcoholics were found to have a statistically significant increase in prolactin and a decrease in testosterone. A definite ratio in the secretion of these hormones differing from that in the control group was elucidated. This ratio (prolactin-testosterone index) is proposed as a diagnostic test of alcoholism. PMID:6441404

1984-01-01

354

Urethral carcinoma and hyperplasia in male and female B6C3F1 mice treated with 3,3?,4,4?- Tetrachloroazobenzene (TCAB)  

UK PubMed Central (United Kingdom)

B6C3F1 mice chronically exposed to 3,3′,4,4′-tetrachloroazobenzene (TCAB), a contaminant of dichloroaniline-derived herbicides, developed a number of neoplastic and nonneoplastic...Full Text Available

2010-01-01

355

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia  

UK PubMed Central (United Kingdom)

Chronic HTLV-I (human T cell lymphotropic virus type I) infection may cause adult T cell leukemia/lymphoma (ATL), a disease with dismal long-term prognosis. The HTLV-I transactivator, Tax, initiates...Full Text Available

2010-12-20

356

The epidemiology and experience of atopic eczema during childhood: a discussion paper on the implications of current knowledge for health care, public health policy and research  

UK PubMed Central (United Kingdom)

Atopic eczema is a chronic skin condition affecting between 5% and 20% of children aged up to 11 years at one time or other. Research suggests that prevalence is increasing and various environmental...Full Text Available

2000-08-01

357

The effect of ethanol on "3"5-S-TBPS binding to mouse brain membranes in the presence of chloride  

International Nuclear Information System (INIS)

The effect of in vitro and in vivo administration of ethanol on the binding of "3"5S-t-butyl-bicyclophosphorothionate ("3"5S-TBPS) to cortical brain membranes of C57B1 mice was investigated using KCl (100 mM) containing assay media. The in vitro addition of ethanol produced a dose-dependent inhibition of basal "3"5S-TBPS binding. In the presence of chloride ions, GABA and pentobarbital had a biphasic action (stimulation followed by inhibition) on "3"5S-TBPS binding, whereas diazepam only stimulated the binding. Ethanol reduced the stimulatory effects of GABA and pentobarbital in a dose-dependent manner, but had no effect on the enhancement of "3"5S-TBPS binding produced by diazepam. "3"5S-TBPS binding to cortical brain membranes was inhibited by the putative Cl"- channel blocking agent DIDS. This inhibitory action of DIDS was significantly, and dose-dependently reduced by ethanol (#<=# 100 mM ethanol). Chronic ethanol ingestion in vivo, which produced tolerance ...

358

Particulate air pollution and chronic ischemic heart disease in the eastern United States: a county level ecological study using satellite aerosol data  

UK PubMed Central (United Kingdom)

BackgroundThere are several known factors that cause ischemic heart disease. However, the part played by air pollution still remains something of a mystery. Recent attention has...Full Text Available

359

On the effect of ionizing radiation on some factors of hamster natural immunity in norm and in himenolepis diminuta invasion  

International Nuclear Information System (INIS)

Effect of single and chronic irradiation on factors of hamsters natural immunity such as complement, lysozyme and antibodies in norm and in the cestode invasion has been investigated. Significant phase changes in the complement activity level, lysozyme content and specific antibodies tite have been shown to occur in hamster blood under the influence of ionizing radiation. Cestode invasion in irradiated host organism increases the negative effect of ionizing radiation on the hamster immyne system.

1994-01-01

360

Non-neoplastic pulmonary disease from inhaled radon daughters with uranium ore dust in beagle dogs  

International Nuclear Information System (INIS)

Daily exposures of adult beagle dogs to inhaled radon daughters plus uranium ore dust, with and without concurrent cigarette smoking, for 2 to 5-1/2 yr have produced massive pulmonary fibrosis and severe emphysema. The cumulative exposure doses are similar to those associated with a 5-fold or greater increase in death rate of uranium miners due to chronic respiratory insufficiency, including pneumoconiosis, pulmonary fibrosis, and emphysema.

1977-05-01

361

Mucociliary transport and upper airway disease  

International Nuclear Information System (INIS)

Mucociliary transport so critical in nasal, paranasal sinus, and middle ear physiology is impaired in chronic sinsusitis and otitis media by factors such as increased mucus viscoelasticity, decreased ciliary area, and primary or secondary ciliary immotility. We reviewed the pathophysiology of primary ciliary dyskinesia, otitis media with effusion, chronic sinusitis, and allergic rhinitis in terms of mucociliary transport. Subjects with primary ciliary dyskinesia may experience recurrent middle ear infection, chronic airway infection, predominantly lower-lobe bronchiectasis, male sterility, or situs inversus. Primary ciliary dyskinesia is sometimes difficult to diagnose in cases without situs inversus. Nasal nitric oxide concentration in such patients decreases, although why is unclear. Mutations may involve dynein arm intermediate chain 1 (DNAI1) or dynein arm heavy chain 5 (DNAH5). Mucociliary clearance decreases more in ...

2010-05-01

362

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.  

UK PubMed Central (United Kingdom)

We have recently shown that viable Borrelia burgdorferi organisms induce a chronic infection associated with arthritis and carditis in severe combined immunodeficiency (scid) mice but not in immunocompetent...Full Text Available

1990-05-01

363

Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program  

UK PubMed Central (United Kingdom)

AimsThe prevalence and importance of liver function test (LFT) abnormalities in a large contemporary cohort of heart failure patients have not been systematically evaluated.Full Text Available

2009-02-01

364

Ionising radiation. Part 2  

Energy Technology Data Exchange (ETDEWEB)

A brief tutorial on the health effects of ionising radiation is presented. The distinction between somatic and genetic health effects is explained. The two types of somatic health effects, i.e., acute and chronic effects, are discussed, as well as the concepts of ''deterministic'' and ''stochastic'' (also called ''probabilistic'') health effects. The possibility of cancer caused by DNA damage is discussed. The document ends with the definition of some key radiation terms.

2000-11-01

365

Investigation of genomic instability by assay of DNA fingerprint from the offspring of male mice exposed to chronic low-level #gamma#-radiation  

International Nuclear Information System (INIS)

By polymerase chain reaction with arbitrary primer (AP-PCR), the possibility of transmission of genome instability to somatic cells of the offspring (F_1 generation) from male parents of mice exposed to chronic low-dose #gamma#-radiation was studied. Male mice 15 days after exposure to 10-50 cGy were mated with unirradiated females. Biopsies were taken from tale tips of two month-old mice progeny for DNA separation. Primer in the AP-PCR was 20-mer oligonucleotide flanking the micro-satellite locus Atplb2 on chromosome 11 of the mouse. Comparative analysis of individual fingerprints of AP-PCR products on DNA-templates from the offspring of irradiated and unirradiated male mice revealed an increased variability of micro-satellite-associated sequences in the genome of the offspring of males exposed to 25 and 50 cGy. DNA-fingerprints of the offspring of male mice exposed to chronic irradiation doses 10 and 25 cGy. 15 days before fertilization (at ...

2000-11-20

366

Insights in the use of health care services in chronic benign pain in childhood and adolescence.  

Science.gov (United States)

The utilization of health care services in children and adolescents with chronic benign pain was studied in a Dutch population sample of 254 chronic pain sufferers aged 0-18 years. Children and adolescents who had reported chronic pain (continuous or recurrent pain >3 months) in our previous prevalence study were asked to keep a 3-week diary on their pain and to fill out questionnaires on background factors, health care use and the impact of pain. Parent ratings were used for children aged 0-11 years, self-report was used in adolescents (12-18 years). In a 3-month period, in 53.4% of the cases medication was used for pain, and general practitioners and specialists were consulted for pain in 31.1% and 13.9% of subjects, respectively. Physiotherapists, psychologists and alternative health providers were visited by 11.5, 2.8, and 4.0%, respectively. In the preceding year, 6.4% had been hospitalized due to pain. The most ...

2001-11-01

367

IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells  

UK PubMed Central (United Kingdom)

Nonthyroidal illness syndrome (NTIS) is a state of low serum 3,5,3′ triiodothyronine (T3) that occurs in chronically ill patients; the degree of reduction in T3 is associated...Full Text Available

2011-05-02

368

Hypothyroidism in Noninterferon Treated-HCV Infected Individuals Is Associated with Abnormalities in the Regulation of Th17 Cells  

UK PubMed Central (United Kingdom)

HCV-Ag-specific TH17 cells secrete IL17, a cytokine involved in autoimmune diseases and regulated by IL10 and TGF-b. 5–12% of patients with chronic HCV infection have hypothyroidism. We evaluated...Full Text Available

2010-01-01

369

Heavy water leak due to fretting of DN tube  

International Nuclear Information System (INIS)

Wolsung nuclear power plant has experienced four occasions of reactor shutdown owing to heavy water leaks since its commercial operation. Among these heavy water leaks, only one case was acute and brought about reactor shutdown but the other cases listed below were chronic and repaired after manual reactor shutdown. (author). 4 tabs., 10 figs.

1989-06-04

370

Extracorporeal Photochemotherapy as a Challenging Treatment for Cutaneous T-Cell Lymphoma, Acute and Chronic Graft-versus-Host Disease, Organ Rejection and T-Lymphocyte-Mediated Autoimmune Diseases  

UK PubMed Central (United Kingdom)

Summary20 years ago, in 1987, Edelson and co-workers published their first report on the effectiveness of a new procedure, called extracorporeal photochemotherapy (ECP), in patients...Full Text Available

2008-01-01

371

Exploring Wait List Prioritization and Management Strategies for Publicly Funded Ambulatory Rehabilitation Services in Ontario, Canada: Further Evidence of Barriers to Access for People with Chronic Disease  

UK PubMed Central (United Kingdom)

Background:Timely access to publicly funded health services is a priority issue across the healthcare continuum in Canada. The purpose of this study was to examine wait list management...Full Text Available

2010-05-01

372

Estimating Regional Spatial and Temporal Variability of PM2.5 Concentrations Using Satellite Data, Meteorology, and Land Use Information  

UK PubMed Central (United Kingdom)

BackgroundStudies of chronic health effects due to exposures to particulate matter with aerodynamic diameters ≤ 2.5 μm (PM2.5) are often limited by sparse...Full Text Available

2009-06-01

373

Establishment of stable Huh-7 cell lines expressing various hepatitis C virus genotype 3a protein: an in-vitro testing system for novel anti-HCV drugs  

UK PubMed Central (United Kingdom)

BackgroundHepatitis C virus (HCV) infection is the leading cause of chronic hepatitis which progresses to hepatocellular carcinoma (HCC) afflicting > 170 million people worldwide....Full Text Available

374

Effects of Low Dose Parathyroid Hormone on Bone Mass, Turnover, and Ectopic Osteoinduction in a Rat Model for Chronic Alcohol Abuse  

UK PubMed Central (United Kingdom)

Parathyroid hormone (PTH) is used clinically in osteoporotic patients to increase bone mass by enhancing bone formation. PTH therapy is not uniformly effective at all skeletal sites and “lifestyle”...Full Text Available

2008-04-01

375

Effects of Chronic JP-8 Jet Fuel Exposure on Lung Function.  

Science.gov (United States)

The past three years of work for the Air Force Office of Scientific Research has resulted in the development of a congenic mouse model of JP-8 jet fuel exposure, the role of substance P in the JP-8 jet fuel-induced lung injury process, and development of ...

1997-01-01

376

Differential Changes in Heat Shock Protein-, Lipoarabinomannan-, and Purified Protein Derivative-Specific Immunoglobulin G1 and G2 Isotype Responses during Bovine Mycobacterium avium subsp. paratuberculosis Infection  

UK PubMed Central (United Kingdom)

Bovine paratuberculosis is caused by infection of young calves with Mycobacterium avium subsp. paratuberculosis. In some of the chronically infected cows the long asymptomatic...Full Text Available

2001-03-01

377

Commentary  

International Nuclear Information System (INIS)

1. It is not possible to give a threshold value for the dose - nor for genetic neither for somatic late effects. 2. The linear dose-effect exprapolation is not conservative in the sense of 'fying on the safe side'. 3. There has been found no relative reduction of the effects at chronic radiation exposure in man. 4 The numbers given by authorities and utilities for damage rates per rem received, that are called upper limits, are by far too low. (orig./HP).

1980-02-01

378

Cerebral sparganosis. Case report.  

Science.gov (United States)

The tapeworm Spirometra mansonoides infects man worldwide, particularly in Asian countries. Rarely, the central nervous system is involved; such a case is presented here. In the total of 12 reported cases, including the case described, the worm presented clinically as a mass suspicious for neoplasm or chronic abscess cavity. Surgical removal was invariably curative in each case. Although infrequent, the possibility of tapeworm infection should be entertained in the evaluation of intracranial masses in patients who have visited exotic locales. PMID:2191089

1990-07-01

379

Cellular Sources of Transforming Growth Factor-? Isoforms in Early and Chronic Radiation Enteropathy  

UK PubMed Central (United Kingdom)

The three mammalian transforming growth factor (TGF)-β isoforms (TGF-β1, TGF-β2, and TGF-β3) differ in their putative roles in radiation-induced fibrosis in intestine...Full Text Available

1998-11-01

380

CT scan findings in cerebral paragonimiasis  

International Nuclear Information System (INIS)

Computed tomography was performed on 5 patients with chronic cerebral paragonimiasis. CT showed solitary or multiple, amorphous, round, or oval calcifications, and ventricular enlargement in all 5 cases. A large low-density area is also found in 4 of the 5 cases. These CT findings are compatible with previously reported findings of simple X-ray films of the skull, pneumoencephalography, and pathological studies. (author).

1982-01-01

381

CT manifestations of ileal dysgenesis  

Energy Technology Data Exchange (ETDEWEB)

Ileal dysgenesis is an uncommon condition of unknown etiology occurring in the distal ileum in the region of the vitelline duct. The CT appearance of this lesion, although not previously described to our knowledge, is characteristic. We report a patient with ileal dysgenesis who had an abdominal CT scan to evaluate chronic iron deficiency anemia and protein-losing enteropathy. Recognition of this lesion by pediatric radiologists is important; so that surgical treatment, which is simple and effective, can be initiated quickly. (orig.)

2007-02-15

382

Biological effects and health risks following to the exposition to ionizing radiation  

International Nuclear Information System (INIS)

Late somatic and genetic radiation effects are imperfectly understood, particularly in the human species. However the available information is sufficient to draw reasonably precise risk estimates in man for many types of damage by means of scientifically justifiable procedures and with the necessary caution. This overall absolute risk of major somatic and genetic damage may be set at around 10"-"4/rad of chronic whole-body doses.

1976-01-01

383

Performance Assessment Monitoring Plan for the Hanford Site Low-Level Burial Grounds  

Energy Technology Data Exchange (ETDEWEB)

The U.S. Department of Energy Order 435.1, Radioactive Waste Management, requires a disposal authorization statement authorizing operation (or continued operation) for low-level waste disposal facilities. In fulfillment of these requirements, a disposal authorization statement was issued on October 25, 1999, authorizing the Hanford Site to transfer, receive, possess, and dispose of low-level radioactive waste at the 200 East Area burial grounds and the 200 West Area burial grounds. One of the conditions is that monitoring plans for the 200 East Area and 200 West Area low-level burial grounds be written and approved by the Richland Operations Office. As a result of a record of decision for the Hanford Site Solid Waste Program and acceptance of the Hanford Site Solid Waste Environmental Impact Statement, the use of the low-level burial ground (LLBG) as a disposal facility for low-level and mixed low-level wastes has been restricted to lined trenches and the Navy ...

2006-03-30

384

Uncertainties of retrospective radon concentration measurements by multilayer surface trap detector  

Energy Technology Data Exchange (ETDEWEB)

The detector for retrospective radon exposure measurements is developed. The detector consists of the multilayer package of solid-state nuclear track detectors LR-115 type. Nitrocellulose films works both as {alpha}-particle detector and as absorber decreasing the energy of {alpha}-particles. The uncertainties of implanted {sup 210}Pb measurements by two- and three-layer detectors are assessed in dependence on surface {sup 210}Po activity and gross background activity of the glass. The generalized compartment behavior model of radon decay products in the room atmosphere was developed and verified. It is shown that the most influencing parameters on the value of conversion coefficient from {sup 210}Po surface activity to average radon concentration are aerosol particles concentration, deposition velocity of unattached {sup 218}Po and air exchange rate. It is demonstrated that with the use of additional information on surface to volume room ratio, air exchange rate ...

2006-07-01

385

The transfer of trichloroethylene (TCE) from a shower to indoor air: Experimental measurements and their implications  

Energy Technology Data Exchange (ETDEWEB)

Experiments were performed to measure the transfer of trichloroethylene (TCE), a volatile organic compound (VOC), from tap water in showers to indoor air. In these experiments, the loss of TCE from tap water in the shower is based on the difference between influent and effluent concentrations.We have developed and previously published a three-compartment model, which we use to simulate the 24-h concentration history of VOCs in the shower, bathroom, and remaining household volumes resulting from the use of contaminated tap water. An important input to this model is the transfer efficiency of the VOC from water to air. The experiments reveal that the transfer efficiency of TCE from shower water to air has an arithmetic mean value of 51 percent and an arithmetic standard deviation of 9 percent. Analysis of the results shows that there is no statistically significant difference between the transfer efficiency measured with hot (37C) or cold (22C) shower water and that ...

1991-08-01

386

Sinonasal malignant tumors involvement of the orbit and skull: a computed tomography study  

International Nuclear Information System (INIS)

Malignant tumors of the sinonasal cavities are rare and often diagnosed late in the course of the disease. These tumors can extend into regions such as the orbit and brain, where treatment is difficult. Ten patients with non treated sinonasal malignant neoplasms and radiological evidence of tumor extension into the orbit and brain were studied with computed tomography. Five (50%) tumors were epithelial neoplasms whereas squamous cell carcinoma was the most common type (3 cases). The ethmoidal sinus was the most common site of origin of the tumors (40%), followed by the maxillary sinus (30%) and nasal cavity (30%). A total of 16 orbits were involved since 6 patients (60%) had bilateral orbital involvement. The tumors extended more often into the orbits through erosion of the medial and inferior orbital bones. All orbital compartments were involved in the majority of the orbits. Tumoral extension into the cranial cavity was more common through the ethmoidal (70%) and ...

2002-01-01

387

Silver nanoparticles directly formed on natural macroporous matrix and their anti-microbial activities  

Energy Technology Data Exchange (ETDEWEB)

In this study, silver nanoparticles were formed on a natural macroporous matrix, the stem of rice-paper plant, by reducing Ag{sup +} in aqueous solution through in situ processing without using any other stabilizers. The pores of the matrix, with their size of about 100 {mu}m, were thought to act as reaction compartments for the nucleation and growth of silver nanoparticles, and the control of nucleation of silver crystal during the reduction reaction was found to be important to the successful formation of nanosized silver particles onto the matrix. The diameter and amount of resultant silver particles can be controlled by changing the reaction conditions. Under optimized conditions, the content of silver particles in the matrix can reach as high as 1.8 wt% with the particle diameters being kept below 100 nm. The anti-microbial activities in terms of minimum inhibitory concentration (MIC) for the silver nanoparticle composites against Escherichia coli and Candida ...

2007-02-07

388

Short rotation coppice with Robinia pseudoacacia L. : a land use option for carbon sequestration on reclaimed mine sites  

Energy Technology Data Exchange (ETDEWEB)

A study in northeast Germany has shown that the establishment of short rotation coppices (SRC) of Robinia pseudoacacia L. may be a viable option for improving farmers income on marginal soils. The plantations produce woody biomass at a fast rate for energy use. Carbon is accumulated in the harvestable biomass, as well as in the stump and the roots. These plant compartments form a long-term carbon storage pool because they can survive a harvest, stay vital at the site and continue to grow as the plant ages. As organic litter decomposes, additional carbon is sequestered under SRC as soil organic carbon. The carbon sequestration in SRC of R. pseudoacacia on mining sites within the Lower Lusatian region in northeast Germany was studied and the results were complemented with findings of current field studies conducted on reclaimed mine sites. The average above ground dry matter productivity of R. pseudoacacia was found to be 3 to 10 Mg per hectare per year, depending on ...

2010-07-01

389

Phosphate/UO{sub 2} interaction during in vitro dissolution of inhalable particles in a medium simulating the phagolysosomal compartment  

Energy Technology Data Exchange (ETDEWEB)

Qualitative and quantitative methods have been developed to relate phosphate/UO{sub 2} interactions and U dissolution, in vitro, in a medium containing 0 or 10 mM phosphate concentrations at pH 5. This was performed by Energy Dispersive X ray Spectrometry (EDS) at 200 kV on entire particles and by fluorimetric measurement. The U dissolution rate was larger in a medium without phosphate than in a medium containing 10 mM phosphate. During the first day, the initial U dissolution involved 80.55% and 91.13% of the powder in media with and without phosphate respectively. From 5 to 15 d after beginning the assay, the dissolution half-times were longer than 92 d and 22 d for media with and without phosphate. EDS analyses have shown a constant P/U X ray intensity ratio for reference U{sub 2}O(PO{sub 4}){sub 2} for the same range of particle diameter. A gradual increase of this ratio was measured for UO{sub 2} incubated in a 10 mM phosphate medium throughout the experiment. (author)

1998-07-01

390

Overview of the 1995 NATO ARW on nuclear submarine decommissioning and related problems  

International Nuclear Information System (INIS)

The NATO Advanced Research Workshop on Nuclear Submarine Decommissioning and Related Problems was held in Moscow June 19--22, 1995. It was preceded by a visit to the Zvezdotchka Shipyard at Severodvinsk, a repair and maintenance yard for Russian nuclear submarines, for a subgroup of the workshop attendees. Most of the material in this paper is drawn directly form the workshop proceedings. Slightly less than 500 nuclear ships and submarines (the vast majority are submarines) have been constructed by the countries with nuclear navies. This includes approximately 250 by Russia, 195 by the United States, 23 by the United Kingdom, 11 by France and 6 by China. By the year 2000 it is expected that approximately one-half of these nuclear vessels will be removed from service and in various states of decommissioning. A newspaper account in June 1997 indicated that 156 Russian nuclear submarines had been removed from service. In August 1996 it was reported that 55 reactor ...

1997-11-21

391

Operational feedback and design improvements in reactor regulating system of 540MWe PHWR  

International Nuclear Information System (INIS)

Reactor Regulating System (RRS) of TAPP-3 and 4 (540 MWe PHWR) addresses issues of elaborate Flux Tilt Control as applied to large Reactor Cores in addition to the traditional Bulk Power (Actual Power) Control. The control of Bulk and Zonal Power by RRS through the use of Zonal Control Compartments (ZCCs) has been successfully demonstrated in the Indian PHWRs for the first time. Features like automation in Demand Power Maneuvering, Manual Movement of Reactivity Devices through the Human Machine Interface (HMI) and the supervised withdrawal of Shut-off Rods during Auto Criticality are also included. Special algorithms to measure and control the individual Zone Power and Bulk Power also form part of RRS algorithms. This paper describes the salient features of RRS of TAPP-3 and 4 and the improvement carried out based on the feedback of past 1 year of operation of TAPP-4 at around 90 % FP. (author)

2006-11-13

392

Numerical Simulation of a Compartment Fire in a Nuclear Power Plant Containment Building  

International Nuclear Information System (INIS)

The current trend towards the increased use of risk assessment in the regulation of nuclear power plants will inevitably result in changes in the analysis of fire protection systems and the methods of analysis. Before fire protection can be regulated on a risk basis, a consensus must be reached on a number of issues. One key issue is what types of computational tools will be allowable for analyzing fire events, and what types of scenarios those tools will be approved for use. Reaching this consensus will require an understanding of the types of computational tools available and their inherent advantages and disadvantages. To aid with this understanding, three different methods of fire simulation are applied to an oil pool fire test in the HDR (Heiss Dampf Reaktor) containment test facility. These methods are a hand calculation, the zone model code CFAST (Consolidated Model of Fire Growth and Smoke Transport), and the computational fluid dynamics code FDS (Fire Dynamics Simulator). Each ...

2002-04-14

393

Nuclear Targeting of Methyl-Recycling Enzymes in Arabidopsis thaliana Is Mediated by Specific Protein Interactions.  

Science.gov (United States)

Numerous transmethylation reactions are required for normal plant growth and development. S-adenosylhomocysteine hydrolase (SAHH) and adenosine kinase (ADK) act coordinately to recycle the by-product of these reactions, S-adenosylhomocysteine (SAH) that would otherwise competitively inhibit methyltransferase (MT) activities. Here, we report on investigations to understand how the SAH produced in the nucleus is metabolized by SAHH and ADK. Localization analyses using green fluorescent fusion proteins demonstrated that both enzymes are capable of localizing to the cytoplasm and the nucleus, although no obvious nuclear localization signal was found in their sequences. Deletion analysis revealed that a 41-amino-acid segment of SAHH (Gly(150)-Lys(190)) is required for nuclear targeting of this enzyme. This segment is surface exposed, shows unique sequence conservation patterns in plant SAHHs, and possesses additional features of protein-protein interaction motifs. ADK and SAHH interact in ...

2011-10-01

394

Liquid and gaseous effluent control and monitoring at Cernavoda NPP and the assessment of the environmental impact  

International Nuclear Information System (INIS)

The release of any potential radioactive pollutant to the environment during routine operation of a Nuclear Power Plant should be the subject of appropriate controls and assessments. It is impossible to monitor directly the dose contribution of normal releases because the environmental radioactivity levels are very small but source monitoring provides a means of assessing the radiation exposure of population groups, critical groups and individual members of the public. Derived emissions limits ( DELs ) are used to quantify the relationship between releases of radioactivity and doses to public - critical groups. CNE Cernavoda DELs are based on a pathway analysis conducted for Cernavoda site specific conditions and they were computed using a compartment transfer model. Annual air and water emissions for the most significant radionuclides between 1997 and 2008 are presented in terms of doses and can be observed that population doses are far below the authorized limit ...

2009-10-12

395

Ion movements in cell death: from protection to execution  

Scientific Electronic Library Online (English)

Abstract in english Cell death is preceded by severe disruption of inorganic ion homeostasis. Seconds to minutes after an injury, calcium, protons, sodium, potassium and chloride are exchanged between the cell and its environment. Simultaneously, ions are shifted between membrane compartments inside the cell, whereby mitochondria and endoplasmic reticulum play a crucial role. Depending of the type and severity of injury, two mutually exclusive metastable states can be reached, which predict (more) the final outcome. Cells characterized by large increases in cytosolic [Ca2+], [Na+]; and [Mg2+] swell and die by necrosis; alternatively, cells characterized by high [H+]and low [K+], with normal [Na+] and normal to moderate [Ca2+] increases die by apoptosis. The levels of these ions represent central determinants in signaling events leading to cell death. Their movements are explained mechanistically by specific modulation of membrane transport proteins including ...

2002-01-01

396

Improved recovery demonstration for Williston Basin carbonates. Quarterly report, January 1, 1996--March 31, 1996  

Science.gov (United States)

The purpose of this project is to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in- place, methods for improved completion efficiency and the suitability of waterflooding in certain shallow-shelf carbonate reservoirs in the Williston Basin, Montana, North Dakota and South Dakota. Improved reservoir characterization utilizing 3-dimensional and multi-component seismic area is being investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterization tools are integrated with geological and engineering studies. Improved completion efficiency is being tested with extended- reach jetting lance and other ultra-short radius lateral technologies. Improved completion efficiency, additional wells at closer spacings better estimates of oil-in-place will result in additional oil production by primary and enhanced recovery processes. Technical progress is described for field ...

1996-07-01

397

Human exposure to volatile organic compounds in household tap water: the indoor inhalation pathway  

International Nuclear Information System (INIS)

This paper addresses the quantification of human exposure to volatile organic compounds (VOC's) as a result of mass transfer from tap water to indoor air. A three-compartment model is developed and used to simulate the 24-h concentration profile within the shower, bathroom, and remaining household volumes of a dwelling. Mass transfers from water to air are derived from measured data for radon and adjusted to account for the difference in mass-transfer properties for VOC's. A preliminary data base for household parameters is used to calculate a range of concentrations and human exposures in U.S. dwellings. The model is used to estimate exposure factors for seven compounds-chloroform, ethylene dibromide, dibromo-chloropropane, methylchloroform, perchloroethylene, trichloroethylene, and carbon tetrachloride. The calculated ratio of indoor-air exposure to tap water concentration is compared to measured values for one of the compounds, chloroform. A sensitivity analysis ...

398

High temperature aluminum electrolytic capacitors for ULEV inverters  

Energy Technology Data Exchange (ETDEWEB)

A comparison between the concepts of the hybrid electric vehicle (HEV) and the ultra low emission vehicle (ULEV) was presented. The ULEV uses a much larger engine compared to the HEV, but it uses a lower Kw generator/motor and inverter/charger to use the latest engine and battery technology. The underlying goal of the ULEV is to supply auxiliary power under start-up and heavy load conditions and to remove indirect systems such as steering, starting and blower control from the engine via small electric drives. The challenge is to build a ULEV that is robust enough to withstand any environmental conditions. Since the ULEV engine is larger, it can experience compartment temperatures greater than 125 degrees C, which limits the use of conventional filter capacitors. Nippon Chemi-Con has recently developed U787D, the world's first continuous 150 degrees C rated aluminum electrolytic capacitor designed to meet the ambient, ripple currents and vibration ...

2000-07-01

399

GROWTH REGULATION IN ROUS SARCOMA VIRUS INFECTED CHICKEN EMBRYO FIBROBLASTS: THE ROLE OF THE src GENE  

Energy Technology Data Exchange (ETDEWEB)

We report here a study of the mechanisms leading to loss of growth control in chicken embryo fibroblasts transformed by Rous sarcoma virus (RSV). We have been particularly concerned with the role of the src gene in this process, and have used RSV mutants temperature sensitive (ts) for transformation to investigate the nature of the growth regulatory lesion. The two principal findings were (1) the stationary phase of the cell cycle (G{sub 1}) in chick embryo fibroblasts seems to have two distinct regulatory compartments (using the terminology of Brooks et al. we refer to these as 'Q' and 'A' states). When rendered stationary at 41.5 C by serum deprivation, normal cells enter a Q state, but cells infected with the ts-mutant occupy an A state. (2) Whereas normal cells can occupy either state depending on culture conditions, the ts-infected cells, at 41.5 C, do not seem to enter Q even though a known src gene product, a kinase, is ...

1980-07-01

400

GDH pipe break transient analysis of the RBMK - 1500.  

Energy Technology Data Exchange (ETDEWEB)

Presented in this paper is the transient analysis of a Group Distribution Header (GDH) following a guillotine break at the end of the header. The GDH is the most important component of reactor safety in case of accidents. Emergency Core Cooling System (ECCS) piping is connected to the GDH piping such that, during an accident, coolant passes from the GDH into the ECCS. The GDH that is propelled into motion after a guillotine break can impact neighboring GDH pipes or the nearest wall of the compartment. The cases of GDH impact on an adjacent GDH and its attached piping are investigated in this paper. A whipping RBMK-1500 GDH along with neighboring concrete walls and pipelines is modeled using finite elements. The finite element code NEPTUNE used in this study enables a dynamic pipe whip structural analysis that accommodates large displacements and nonlinear material characteristics. The results of the study indicate that a whipping GDH pipe would not significantly ...

2002-05-15

401

G3 model of gas and liquid migration from grout containing radioactive waste  

Energy Technology Data Exchange (ETDEWEB)

Grout has been evaluated as a means of containing low-level radioactive waste for long-term disposal. Concerns about hydrogen and reactive gas generation in the Hanford Site grout disposal facility lead to the development of the G3 model, which has predicted buildup of radiolytically formed gases in the grout region and their migration to air-filled regions. The G3 model is a one-dimensional code that couples models of gas diffusion with two-phase gas and liquid flow. It was coupled to a compartment diffusion model and these models predicted the concentrations of hydrogen I nitrous oxide, and other gases in air-filled regions of the grout disposal facility. The results have served as the technical basis for safety studies. A unique finding of the G3 model was that a liquid return, or expulsion of unbound liquid from the grout region, could occur. This liquid return is driven by displacement caused by gas bubbles that form within the grout`s microstructure. Liquid ...

1994-11-01

402

Experimental simulation of heat transfer augmentation by break-jets in passive containment cooling system  

International Nuclear Information System (INIS)

The studies of forced jet augmentation of natural convection heat transfer are introduced. It investigates experimentally mixed convection and heat transfer augmentation by forced jets in a large rectangular enclosure with a vertical cooling surface. The experiment is designed to measure the key parameters governing the heat transfer augmentation by a forced jet, and to investigate the effects of geometric factors, including the jet diameter, jet injection orientation, interior structures, and enclosure aspect ratio, on conditions simulating those of actual passive containment cooling systems and scales approaching those of actual containment buildings or compartments. The tests that cover a variety of injection modes will contribute to reveal the nature of mixing and stratification phenomena under accident conditions to a new generation of inherently safe reactors. With similarity considerations on governing equations, the heat transfer of mixed convection can be ...

2010-02-01

403

Evaluation of pipe whip impacts on neighboring piping and walls of the Ignalina nuclear power plant.  

Energy Technology Data Exchange (ETDEWEB)

Presented in this paper is the transient analysis of a Group Distribution Header (GDH) following a guillotine break at the end of the header. The GDH is the most important component of reactor safety in case of accidents. Emergency Core Cooling System (ECCS) piping is connected to the GDH piping such that, during an accident, coolant passes from the GDH into the ECCS. The GDH that is propelled into motion after a guillotine break can impact neighboring GDH pipes or the nearest wall of the compartment. Therefore, two cases are investigated: GDH impact on an adjacent GDH and its attached piping; and GDH impact on an adjacent reinforced concrete wall. A whipping RBMK-1500 GDH along with neighboring concrete walls and pipelines is modeled using finite elements. The finite element code NEPTUNE used in this study enables a dynamic pipe whip structural analysis that accommodates large displacements and nonlinear material characteristics. The results of the study indicate ...

2002-02-26

404

Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension  

Energy Technology Data Exchange (ETDEWEB)

Arachidonic acid is metabolized by means of P450 isoenzyme(s) to form epoxyeicosatrienoic acids (EETs) and their corresponding dihydroxy derivatives (DHETs). In the present study, we established the presence in human urine of 8,9-, 11,12-, and 14,15-EETs and their corresponding DHETs by developing quantitative assays and using negative ion, chemical ionization GC/MS and octadeuterated internal standards. Urinary excretion of 8,9- and 11,12-DHET increased in healthy pregnant women compared with nonpregnant female volunteers. By contrast, excretion of 11,12-DHET and 14,15-DHET, but not the 8,9-DHET regioisomer, increased even further in patients with pregnancy-induced hypertension. Intravenous administration of (3H)14,15-EET to three dogs markedly increased its DHET in plasma. The terminal half-life ranged from 7.9-12.3 min and the volume of distribution (3.5-5.3 liters) suggested limited distribution outside the plasma compartment. Negligible radioactivity was ...

1990-08-01

405

Critical loads for vegetation. Definition, use and limits. Charges critiques pour la vegetation  

Energy Technology Data Exchange (ETDEWEB)

Vegetation is a key compartment of ecosystems. It contains a large part of the biodiversity at the species level. For the evaluation of critical loads, we have to separate different receptors: lower plants (algae, fungi, lichens and mosses) and vascular plants. Trees must be distinguished due to their economic value. We analyze the different changes that pollution produces on vegetation: the state of health of individuals, changes in the biology and genetics at the population level, changes in the biodiversity or the specific composition at the community level. Calculation of critical loads is based on observational or experimental studies, in more or less controlled environments. However, they cannot yet be obtained through models of vegetation changes. Some results have been acquired at the European level, mainly for critical loads for nitrogen, but these results have come mostly from Northern Europe. Moreover, only heathlands and acidic forests have been studied ...

1993-06-01

406

Analyses of postulated accidental releases of UF6 inside process buildings  

International Nuclear Information System (INIS)

Uranium Hexafluoride is a material used in the various processes which comprise the front end of the nuclear fuel cycle (conversion, enrichment and fuel fabrication). Confinement of UF6 is a very important safety requirement since this material is highly reactive and presents safety hazards to humans. The present paper discusses the safety relevant aspects of accidental releases of UF6 inside process confinement buildings. Postulated accidental scenarios are analyzed and their consequences evaluated. Implant releases rates are estimated using computer code predictions. A time dependent homogeneous compartment model is used to predict concentrations of UF6, hydrogen fluoride and uranyl fluoride inside a confinement building, as well as to evaluate source terms released to the atmosphere. These source terms can be used as input to atmospheric dispersion models to evaluate consequences to the environment. The results can also be used to define adequate protective ...

407

A calculation model for thermo-hydraulic analyses of the PGV-1000 steam generator  

International Nuclear Information System (INIS)

A calculation model was developed for the analysis of thermal and hydraulic processes in the PGV-1000 horizontal steam generator. The model makes it possible to examine the hydraulics of the primary medium, i.e., the distribution of flow velocities and mass flows in the exchanger tube system and hydraulic losses of the primary medium in the steam generator during its flow between the two connecting sites to the main circulation pipeline, spatial distribution of heat fluxes between the primary and secondary sides of the steam generator and the total transmitted thermal power, pressure on the secondary side of the generator, natural circulation of the working medium on the secondary side, and the mean circulation number, spatial distribution of the volume fraction of the steam component in the intertubular space, effect of the perforated sheet on the thermo-hydraulic processes in the steam generator, redistribution of the steam component in the compartment above the ...

1994-01-01

408

Challenges in commissioning and operation of 'first-of -its- kind' liquid zone control system in TAPP-3 and 4  

International Nuclear Information System (INIS)

Liquid Zone Control (LZC) System is a 'first-of-its-kind' reactivity control device, designed and implemented at TAPP-3 and 4. The system provides zonal and bulk power control. The system consists of fourteen Zone Control Compartments (ZCCs) containing demineralised light water as neutron absorber. Reactivity control is achieved by varying the level of water in the compartments bi-directionally. Six in-core zircaloy assemblies, housing the fourteen ZCCs and an elaborate process system constitute the LZC system. Measurement of water levels in the ZCCs is done using helium bubbler method. Reliability of ZCC water level measurement is of paramount importance. Commissioning and operating the new system trouble free was a challenge, considering the complex nature of the system. While commissioning the system, level measurement of one of the ZCCs (ZCC - 1) was found erratic and inconsistent. Methodologies were developed to identify the problem and ...

2006-11-13

409

Respiratory morbidity of pattern and model makers exposed to wood, plastic, and metal products  

Energy Technology Data Exchange (ETDEWEB)

Pattern and model makers are skilled tradespersons who may be exposed to hardwoods, softwoods, phenol-formaldehyde resin-impregnated woods, epoxy and polyester/styrene resin systems, and welding and metal-casting fumes. The relationship of respiratory symptoms (wheezing, chronic bronchitis, dyspnea) and pulmonary function (FVC% predicted, FEV1% predicted, FEV1/FVC% predicted) with interview-derived cumulative exposure estimates to specific workplace agents and to all work with wood, plastic, or metal products was investigated in 751 pattern and model makers in southeast Michigan. In stratified analyses and age- and smoking-adjusted linear and logistic regression models, measures of cumulative wood exposures were associated with decrements in pulmonary function and dyspnea, but not with other symptoms. In similar analyses, measures of cumulative plastic exposures were associated with wheezing, chronic bronchitis, and dyspnea, but not with ...

1990-01-01

410

OSCAAR calculations for the Iput dose reconstruction scenario of BIOMASS theme 2  

Energy Technology Data Exchange (ETDEWEB)

This report presents the results obtained from the application of the accident consequence assessment code, called OSCAAR, developed in Japan Atomic Energy Research Institute to the Iput dose reconstruction scenario of BIOMASS Theme 2 organized by International Atomic Energy Agency. The Iput Scenario deals with {sup 137}Cs contamination of the catchment basin and agricultural area in the Bryansk Region of Russia, which was heavily contaminated after the Chernobyl accident. This exercise was used to test the chronic exposure pathway models in OSCAAR with actual measurements and to identify the most important sources of uncertainly with respect to each part of the assessment. The OSCAAR chronic exposure pathway models almost successfully reconstructed the whole 10-year time course of {sup 137}Cs activity concentrations in most requested types of agricultural products and natural foodstuffs. Modeling of {sup 137}Cs downward migration in soils is, ...

2001-01-01

411

Impairments of astrocytes are involved in the D-galactose-induced brain aging  

International Nuclear Information System (INIS)

Astrocyte dysfunction is implicated in course of various age-related neurodegenerative diseases. Chronic injection of D-galactose can cause a progressive deterioration in learning and memory capacity and serve as an animal model of aging. To investigate the involvement of astrocytes in this model, oxidative stress biomarkers, biochemical and pathological changes of astrocytes were examined in the hippocampus of the rats with six weeks of D-galactose injection. D-galactose-injected rats displayed impaired antioxidant systems, an increase in nitric oxide levels, and a decrease in reduced glutathione levels. Consistently, western blotting and immunostaining of glial fibrillary acidic protein showed extensive activation of astrocytes. Double-immunofluorescent staining further showed activated astrocytes highly expressed inducible nitric oxide synthase. Electron microscopy demonstrated the degeneration of astrocytes, especially in the aggregated area of synapse and ...

2008-05-16

412

Effects of chronic treatment with honokiol in spontaneously hypertensive rats.  

Science.gov (United States)

The present study was performed to evaluate the antihypertensive effects of honokiol in vivo in spontaneously hypertensive rats (SHR). The effects of honokiol were investigated by determination of the blood pressure, vascular reactivity, oxidative parameters, and histologic change in the aorta. Long-term administration of honokiol (400 mg/kg/d) to SHR decreased systolic blood pressure significantly. Honokiol (200, 400 mg/kg/d) enhanced the aortic relaxation in response to acetylcholine after 49-d treatment, but had no significant effects on the relaxation to sodium nitroprusside. The oral administration of honokiol significantly increased the plasma level of NO(2(-))/NO(3(-)), but decreased the level of malondialdehyde in liver of SHR compared with the control vehicle. In addition, SHR administered honokiol showed significant reductions in the elastin bands and media thickness in the aorta. These results suggest that chronic treatment with honokiol exerts an ...

2010-01-01

413

Computed tomography and magnetic resonance imaging of acquired abnormalities of the inner ear and cerebello-pontine angle  

International Nuclear Information System (INIS)

CT and MRI of acquired abnormalities of the inner ear and cerebello-pontine angle present themselves with very typical findings. The imaging should be adapted to the pathology looked for and either CT or MRI should be used alone or in combination.CT, especially high resolution CT (HRCT), provides an excellent bone contrast, while MRI has a much superior soft tissue contrast. Acute inflammatory changes of the inner ear are solely depicted by contrast-enhanced MRI. HRCT excellently depicts osseous changes of the inner ear and cerebellopontine angle such as chronic ossifying labyrinthitis occurring after acute labyrinthitis, otosclerotic or traumatic changes. Tumorous changes not yielding to bony changes are best delineated by MRI. Posttraumatic hemorrhage and chronic fibrotic changes within the labyrinth are depicted by MRI, only. In conclusion HRCT and MRI are excellent methods to delineate acquired abnormalities of the inner ear and ...

2003-03-01

414

An availability of brain magnetic resonance imaging (MRI) in the early diagnosis of latent hepatic encephalopathy  

Energy Technology Data Exchange (ETDEWEB)

Brain MRI was carried out in patients with chronic liver diseases. No abnormal findings were recognized in patients with chronic viral hepatitis, while 59.2% of cirrhotics showed a symmetrically strong signal in basal ganglia on T1 weighted image in MRI. This finding significantly related with lowered Fischer`s ratio of serum amino acid, increased levels of serum phenylalanine, tyrosine and hyaluronic acid, prolonged prothrombin time and decreased platelet counts in the peripheral blood. Overt hepatic encephalopathy was observed in 6 of 34 patients with the strong signal in MRI during follow-up period, while none of patients without that finding developed hepatic encephalopathy. These results have indicated that the strong signal in basal ganglia on MRI appears in cirrhotic patients with severe liver dysfunction, and it is an useful index in the early diagnosis of latent hepatic encephalopathy. An improvement of this MRI finding was not ...

1996-03-01

415

A preliminary study of a cartoon measure for children's reactions to chronic trauma.  

Science.gov (United States)

Preliminary psychometric properties of a new instrument, Angie/Andy Cartoon Trauma Scales (ACTS), are presented. Angie/Andy features a cartoon-based methodology, measuring trauma-related sequelae of prolonged, repeated abuse. A sample of 208 children comprised intrafamilial trauma, extrafamilial trauma, combined trauma, and nontrauma groups. Angie/Andy demonstrated high internal consistency, with coefficient alphas from 0.70 to 0.95. The three trauma groups scored significantly higher than the nontrauma group on all scales (p's < 0.0001). Generally, the most severely traumatized group scored significantly higher than the less severely traumatized groups. The number of types of violence exposures correlated with Angie/Andy scores from 0.55 to 0.74. The frequency and severity of trauma exposure correlated with Angie/Andy scores from 0.44 to 0.56. The Angie/Andy parent version correlated with a standardized parent scale from 0.71 to 0.81. Parent/child agreement was significant. ...

2000-08-01

416

A critical review of behavioural treatments for chronic benign pain other than headache.  

Science.gov (United States)

Studies of the effectiveness of operant, relaxation, cognitive, and multimodal behavioural approaches to the treatment of chronic benign pain other than headache were evaluated. In general, the quality of the studies was poor, and most investigations lacked appropriate and adequate control conditions, outcome measures, and/or follow-ups. While outcome reports for all four behavioural treatments have been mainly positive, few data were found which conclusively demonstrate that any of the approaches are effective or that they are the treatment of choice. The data do, however, imply that behavioural approaches may help patients lead more normal and productive lives. Specifically, the literature suggests that: (1) the operant method leads to increased activity levels and decreased pain and drug intake, (2) the relaxation approach results in decreased EMG levels and some pain reductions, (3) the cognitive techniques are speculative at this time, and (4) the multimodal ...

1982-11-01

417

[HBsAG in feces, urine and saliva].  

Science.gov (United States)

After some observations about the tests of the research exposed in the literature, authors illustrate the tests for 142 patients divided into 5 groups: a) patients affected with acute viral hepatitis; b) patients affected with praegressa acute viral hepatitis; c) relatives of patients with acute viral hepatitis; d) volunteers; e) patients affected with chronic uraemia under dialisis periodic treatment. After the testing control, authors, conclude with an hipotesis: a possible epidemic function of faeces, urine saliva, in the passage of the acute viral hepatitis. PMID:488577

418

The language of pain: affective descriptors of pain are a better predictor of psychological disturbance than pattern of sensory and affective descriptors.  

Science.gov (United States)

The language used by chronic benign pain patients to characterize their pain complaint was analyzed to determine the best predictor of psychiatric disturbance. Using the 78 adjectives provided by the McGill Pain Questionnaire, the number of affective descriptors used was the best predictor of psychiatric disturbance. Addition of sensory descriptors either to augment the total number of descriptors used (magnitude) or as a pattern of sensory greater than affective or sensory less than affective failed to increase predictive strength. PMID:6877847

1983-06-01

419

The influence of multiple photoperiods and pinealectomy on gonads, pelage and body weight in male meadow voles, Microtus pennsylvanicus.  

Science.gov (United States)

1. Chronic exposure of male Microtus pennsylvanicus to photoperiods with 8, 10 and 12 hr of light per day results in gonadal regression, molt to winter pelage and significant reductions in body weight and food consumption relative to voles kept on photoperiods with 13 and 14 hr of light per day. 2. A precise critical daylength is observed in this species as exposure to photoperiods with 12 or fewer hours of light per day results in complete gonadal involution, seasonal molt and loss of body weight. 3. Pinealectomy abolishes all short-photoperiod induced responses in this species. PMID:2573458

1989-01-01

420

Role of nuclear medicine bone scans in evaluating pain in athletic injuries  

Energy Technology Data Exchange (ETDEWEB)

The utilization of nuclear medicine bone scanning examinations early in the diagnostic process allows physicians to render prompt and correct treatment in urgent or difficult athletic cases. Bone scanning should be performed for athletic injuries whenever (1) x-rays are normal but bone or joint pain persists; (2) x-rays are positive but it cannot be determined if the findings are acute or chronic; (3) soft-tissue injuries present and x-rays are not useful; and (4) bone pain or joint impairment present without a history of trauma.89 references.

1987-10-01

421

Reciprocal regulation of the neural and innate immune systems  

British Library Electronic Table of Contents (United Kingdom)

Innate immune responses are regulated by microorganisms and cell death, as well as by a third class of stress signal from the nervous and endocrine systems. The innate immune system also feeds back, through the production of cytokines, to regulate the function of the central nervous system (CNS), and this has effects on behaviour. These signals provide an extrinsic regulatory circuit that links physiological, social and environmental conditions, as perceived by the CNS, with transcriptional 'decision-making' in leukocytes. CNS-mediated regulation of innate immune responses optimizes total organism fitness and provides new opportunities for therapeutic control of chronic infectious, inflammatory and neuropsychiatric diseases.

2011-01-01

422

Recent advances in pharmacotherapy for dyspnea in COPD  

British Library Electronic Table of Contents (United Kingdom)

Dyspnea is the most distressing symptom experienced by those suffering from advanced stages of chronic obstructive pulmonary disease (COPD). Activity-related dyspnea in COPD is multifactorial but is associated with increased central neural drive, impaired dynamic respiratory mechanics and abnormal respiratory muscle function. Each of these components can potentially be targeted for pharmacotherapy. Recent advances in the pharmacotherapy of COPD include the development of new long-acting bronchodilators which, when combined, provide sustained improvements in dyspnea. Additionally, novel applications of older therapies such as opiates, furosemide, helium-oxygen, and statins show early promise as dyspnea-relieving interventions in COPD. Effective pharmacological manipulation of the affective ...

2011-01-01

423

Neuroinflammation and brain infections: Historical context and current perspectives  

British Library Electronic Table of Contents (United Kingdom)

An overview of current concepts on neuroinflammation and on the dialogue between neurons and non-neuronal cells in three important infections of the central nervous systems (rabies, cerebral malaria, and human African trypanosomiasis or sleeping sickness) is here presented. Large numbers of cases affected by these diseases are currently reported. In the context of an issue dedicated to Camillo Golgi, historical notes on seminal discoveries on these diseases are also presented. Neuroinflammation is currently closely associated with pathogenetic mechanisms of chronic neurodegenerative diseases. Neuroinflammatory signaling in brain infections is instead relatively neglected in the neuroscience community, despite the fact that the above infections provide paradigmatic examples of alterations o...

2011-01-01

424

Improvement of muscle strenght independently of analgesic effect following spinal cord stimulation. A case report.  

Science.gov (United States)

Spinal cord stimulation (SCS) is frequently used for relief of chronic benign pain resistant to conservative therapies. Clinical practice suggests, at least in patients with failed back surgery syndrome (FBSS), the possibility that SCS significantly improves motor performances. We present here the case of a 41-years-old female patient with FBSS, who showed a clear improvement in muscle strength after SCS, persisting at 6-months follow-up. We speculate that the electrical stimulation of posterior columns could potentiate the caudal, segmental spinal reflexes resulting in a facilitation of motoneurons activation. PMID:16175150

2004-12-01

425

Foraminal stenosis complicating retained broken epidural needle tip -A case report-.  

Science.gov (United States)

Lumbar epidural anesthesia is useful in a variety of chronic benign pain syndromes, including lumbar radiculopathy, low back pain syndrome, spinal stenosis, and vertebral compression fractures. Given the increased number of epidural nerve blocks being performed, some have reported unexplained complications of a transient or permanent nature and with varying degrees of severity. However, no case has been reported of a broken epidural needle tip retained in the lumbar facet joint area. This represents the first reported case presentation of foraminal stenosis developing in a patient after a retained epidural needle tip. PMID:21286465

2010-12-31

426

Cellular Sources of Transforming Growth Factor-? Isoforms in Early and Chronic Radiation Enteropathy  

Science.gov (United States)

The three mammalian transforming growth factor (TGF)-? isoforms (TGF-?1, TGF-?2, and TGF-?3) differ in their putative roles in radiation-induced fibrosis in intestine and other organs. Furthermore, tissue specificity of TGF-? action may result from temporal or spatial changes in production and/or activation. The present study examined shifts in the cell types expressing TGF-? mRNA relative to TGF-? immunoreactivity and histopathological injury during radiation enteropathy development. A 4-cm loop of rat small intestine was locally exposed to 0, 12, or 21-Gy single doses of x-irradiation. Sham-irradiated and irradiated intestine were procured 2 and 26 weeks after irradiation. Cells expressing the TGF-?1, TGF-?2, or TGF-?3 transcripts were identified by in situ hybridization with digoxigenin-labeled riboprobes. Intestinal wall TGF-? immunoreactivity was measured using computerized image analysis, and structural radiation injury was assessed by quantitative histopathology. Normal ...

1998-11-01

427

Cadmium and endrin toxicity to fish in waters containing mineral fibers  

Energy Technology Data Exchange (ETDEWEB)

Taconite tailings and their component asbestiform minerals in Lake Superior water had no demonstrable effect on the chronic toxicity of cadmium to the flagfish, Jordanella floridae. Maximum acceptable toxicant concentrations determined in life cycle tests, where effects on survival, growth, reproduction, and bioconcentration were used as endpoints, were between 3.3 to 7.4, 3.0 to 6.5, and 3.4 to 7.3 micrograms cadmium/liter at 0.004, 0.08, and 0.95 mg/liter taconite tailings concentrations, respectively.

1982-05-01

428

Acquired cystic kidney disease  

Energy Technology Data Exchange (ETDEWEB)

Acquired cystic kidney disease (ACKD), also known as acquired renal cystic disease (ARCD,) occurs in patients who are on dialysis for end-stage renal disease. It is generally accepted that ACKD develops as a consequence of sustained uremia and can first manifest even before dialysis is initiated while the patient is still in chronic renal failure. The role of immune suppression, particularly in transplant recipients, in the development of ACKD, is still under investigation. The prevalence of ACKD is directly related to the duration of dialysis and the risk of cancer is directly related to the presence of cysts. Herein we review the current understanding of the pathophysiology and imaging implications of ACKD. (orig.)

2000-11-01

429

A research agenda to examine the efficacy and relevance of the Transtheoretical Model for physical activity behavior  

British Library Electronic Table of Contents (United Kingdom)

Regular physical activity (PA) decreases the risk of several chronic diseases including some cancers, type II diabetes, obesity, and cardiovascular disease; however, the majority of US adults are not meeting the recommended levels to experience these benefits. To address this public health concern, the underlying mechanisms for behavior change need to be understood, translated and disseminated into appropriately tailored interventions. The Transtheoretical Model (TTM) provides a framework for both the conceptualization and the measurement of behavior change, as well as facilitating promotion strategies that are individualized and easily adapted. The purpose of this manuscript is to present the constructs of the TTM as they relate to PA behavior change. We begin with a brief synopsis of rec...

2011-01-01

430

A Patient-Centric, Provider-Assisted Diabetes Telehealth Self-management Intervention for Urban Minorities  

Science.gov (United States)

This article describes the design and implementation of an online diabetes self-management intervention for a sample of inner-city African Americans with diabetes. Study participants were randomly assigned to the treatment (26) and control (21) conditions. The results indicate that treatment group participants were more likely to achieve positive outcomes in terms of lowered hemoglobin A1c and body mass index measurements than were control group members. These findings support the development of telehealth interventions to promote effective chronic disease management in medically underserved communities.

2011-01-01

431

Relationship between acute ozone responsiveness and chronic loss of lung function in residents of a high-ozone community  

Energy Technology Data Exchange (ETDEWEB)

The authors hypothesized that acute respiratory responsiveness to ozone predicts chronic lung injury from repeated exposure to ozone-containing air pollution. They tested this hypothesis in 164 middle-aged nonsmoking residents of an ozone-polluted community who underwent lung-function measurements during 1986 and 1987 (i.e., time 3). The time-3 study was a follow up of more comprehensive studies conducted in 1977--1978 (time 1) and in 1982--1983 (time 2). In contrast to the apparent rapid (i.e., {approx} 60 ml/y) decline in lung-function measurements between times 1 and 2, their subjects showed little change in forced vital capacity (FVC) or forced expired volume in 1 s (FEV{sub 1.0}) between times 2 and 3, and they experienced a normal decline between times 1 and 3. A subgroup (n = 45) underwent 2-h laboratory ozone exposures to 0.4 ppm ozone, accompanied by intermittent exercise, and they experienced mild acute reductions in FEV{sub 1.0} and FVC, but there was ...

1998-09-01

432

Metallothionein (MT) response after chronic palladium exposure in the zebra mussel, Dreissena polymorpha  

International Nuclear Information System (INIS)

The effects of different exposure concentrations of palladium (Pd) on relative metallothionein (MT) response and bioaccumulation were investigated in zebra mussels (Dreissena polymorpha). The mussels were exposed to 0.05, 5, 50, and 500 ?g/L Pd2+ for 10 weeks under controlled temperature and fasting conditions. Relative MT contents were assessed by a modified Ag-saturation method, which allows to discriminate between MT bound to Pd (Pd-MT) and MT bound to unidentified metals (Ag-MT). Determination of metal contents resulted from atomic absorption spectrometry following a microwave digestion. For unexposed mussels and mussels exposed to 0.05 ?g/L Pd no metal accumulation could be detected. All other exposure concentrations resulted in detectable Pd accumulation in mussels with final tissue concentrations of 96 ?g/g (500 ?g/L), 45 ?g/g (50 ?g/L), and 9 ?g/g (5 ?g/L). Compared with initial levels Pd-MT concentrations at the end of the exposure period were 600 (500 ?g/L), 160 (50 ?g/L), ...

2008-11-01

433

Contribution of pulmonary emphysema to functional impairment in patients with severe chronic obstructive pulmonary disease. A high-resolution CT study  

International Nuclear Information System (INIS)

The purpose of the paper is to investigate whether high-resolution CT (HRCT) can detect the subjects with massive emphysematous destruction in a group of patients with severe chronic obstructive pulmonary disease (COPD) and therefor be of help in selecting the candidates to surgical lung volume reduction. Have been examined 40 former smokers with severe COPD (FEV_1#<=#40% of the predicted value, with no major improvement after inhalation of bronchodilators). The emphysema extent score was significantly correlated with the hematocrit value and Tiffeneau index (p<2) in all the 40 patients. The severity of bronchial obstruction was the same in bronchitis and dyspnoeic patients. The subject with chronic bronchitis had milder emphysema (mean extent 35% versus 47% in the dyspnoeic subjects) and a higher frequency of bronchial involvement. A decrease in FEV_1 was significantly correlated with emphysema extent (p<1) in dyspnoeic, but not in ...

1999-01-01

434

The radioecological risk of decommissioning of nuclear submarines. Possible accidents and normal conditions  

International Nuclear Information System (INIS)

In the report the results of the estimations of radiological risk of various stages of decommissioning of nuclear submarines are presented. At occurrence on nuclear submarine the heavy failure, relating to the class hypotetical volume of acting of radionuclides in atmosphere can reach 1.6E(15) Bq. Results of estimations probable doses on an axis of a trace of a radioactive loop show, that at distribution of radionuclides during atmospheric carry to 'agreed' settlement (500-1000 m) the maximum doses on its territory can make: about 6.0E(-3) Sv (for the whole body); 3.0E(-3) Gy for the leather (basal layer); 6.3E(-2) Gy for the lungs (acute exposure) and up to 1.8 Gy for the thyroid gland. Hypotetical failure for the estimation of the greatest possible radioecological consequences for hydrobiocenosis is considering, connected with single discharge of liquid radioactive waste (LRW) in water area. At navigating failure of the tanker with LRW in water area can arrive 300 M3 of LRW with the ...

2000-05-01

435

Wheat grain quality under enhanced tropospheric CO{sub 2} and O{sub 3} concentrations  

Energy Technology Data Exchange (ETDEWEB)

It is expected that the progressive increase of tropospheric trace gases such as CO{sub 2} and O{sub 3} will have a significant impact on agricultural production. The single and combined effects of CO{sub 2} enrichment and tropospheric O{sub 3} on grain quality characteristics in soft red winter wheat (Triticum aestivum L.) were examined in field studies using 3 m in diam. open-top chambers. Wheat cultivars {open_quotes}Massey{close_quotes} (1991) and {open_quotes}Saluda{close_quotes} (1992) were exposed to two CO{sub 2} concentrations (350 vs. 500 {mu}mol CO{sub 2} mol{sup {minus}1}; 12 h d{sup {minus}1}) in combination with two O{sub 3} regimes (charcoal-filtered air vs. ambient air + 40 {plus_minus} 20 nmol O{sub 3} mol{sup {minus}1}, 7 h d{sup {minus}1}; Monday to Friday) from late March until maturity in June. Grain quality characteristics investigated included: test weight, milling and baking quality, flour yield, protein content, softness equivalent, alkaline water retention ...

1996-11-01

436

[Transdermal opioid administration: the pain plaster].  

Science.gov (United States)

A new method of administration of an opioid was recently registered: fentanyl transdermal (brand name: Durogesic), intended particularly for the indication range 'pain in cancer'. Fentanyl is lipid-soluble so that deposition in the skin takes place and the biological half-life is approximately 20 hours after removal of the plaster. It is safe to start on a basis of an equianalgesic conversion of 100:1 in relation to oral morphine, although this may entail some risk of fentanyl under dosage. The dose adjustment time is 12-24 hours before a constant fentanyl level is reached; therefore, after attaching the first sticking plaster, the original morphine dose should be continued for another 12 hours. In addition, the patient may, if necessary, be given supplementary morphine preferably as a short-acting drug. There seems to be no clear indication for transdermal fentanyl either in neuropathic pain or in chronic benign pain. PMID:9221362

1997-04-26

437

[Efficacy of epidural neurolysis].  

Science.gov (United States)

Forty-one patients were treated with epidural neurolysis using 50 % ethyl alcohol 2 ml. Thirty eight patients were suffering from cancer pain and three patients were complaining of chronic benign pain. Alcohol block was repeated 2.3 times (mean) in the same patient. Thirty patients were followed after the treatment. Forty-seven percent of the patients reported 70 % or greater pain relief and 20 % of the patients reported about 50 % pain relief. Duration of pain relief was from 9 days to 203 days with a mean duration of 54 days. Adverse effects were reported 43 % of the patients. There is no miserable adverse effect. Adverse effect reported most was pain with epidural injection of drugs after the alcohol block had been performed. PMID:8544293

1995-11-01

438

Yttrium Y 90 Ibritumomab Tiuxetan, Fludarabine, Radiation Therapy, and Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma  

Science.gov (United States)

B-cell Chronic Lymphocytic Leukemia; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

2010-10-12

439

Transient azotaemia is associated with a high risk of death in hospitalized patients  

British Library Electronic Table of Contents (United Kingdom)

Background.There are no suitably powered epidemiological studies of `transient azotaemia' (TA). The objective of this study was to describe the epidemiology of TA and its independent association with hospital mortality. We hypothesized that TA would be associated with an independent increase in the risk of death. Methods.We retrospectively studied all patients admitted to a university-affiliated hospital in Australia between January 2000 and December 2002. Patients were excluded if they were <15 years old, were on chronic dialysis, had kidney transplant or if their length of hospital stay was <24 hours. We defined TA as rapidly recovering acute kidney injury (AKI) (return to no-AKI risk, injury, failure, loss, end stage (RIFLE) class within 72 hours of onset). We performed descriptive and ...

2010-01-01

440

The health impact of pemphigus vulgaris and pemphigus foliaceus assessed using the Medical Outcomes Study 36-item short form health survey questionnaire  

British Library Electronic Table of Contents (United Kingdom)

Summary Background Pemphigus vulgaris and pemphigus foliaceus are rare, potentially life-threatening, autoimmune disorders characterized by antibodies to epidermal adhesion molecules. Clinical characteristics are painful chronic erosions of mucous membranes and of the skin. There are only few published studies on the impact of the disease on the health status (HS) of patients with these conditions. Objectives To assess the impact of disease on the HS of patients with pemphigus. Methods Fifty-eight patients enrolled at the Bullous Skin Diseases Unit of IDI-IRCCS in the period January-June 2006 were assessed for their HS using the Medical Outcomes Study 36-item short form health survey (SF-36) questionnaire and for anxiety and depression using the Institute for Personality and Ability Testin...

2008-01-01

441

Systematic Function-Based Intervention for Adolescents with Emotional and Behavioral Disorders in an Alternative Setting: Broadening the Context  

Science.gov (United States)

Three adolescents (ages 14-17) with emotional and behavioral disorders displayed chronic disruptive behavior in their self-contained classrooms at a self-contained alternative school. A descriptive functional behavioral assessment was conducted for each student. Data from file review, structured interviews, and direct observations were used to identify the functions of their disruptive behaviors. Then, function-based interventions were systematically constructed for each student and implemented for an extended period (nearly 6 weeks) within the most problematic situation in their classrooms. The interventions improved each student's behavior and the effects maintained during follow-up and generalized to instruction in a nonintervention classroom. Social validity data comparing the interventions to baseline practices revealed the function-based intervention had moderately higher social validity among teachers and substantially higher social validity among students. ...

2011-02-01

442

Sonography, Computed Tomography and ERCP in the diagnosis of focal exocrine pancreatic disease  

International Nuclear Information System (INIS)

In spite of the improved imaging techniques currently available, mortality for pancreatic cancer is still high, and pancreatics is often diagnosed only in its advanced stages. The authors investigated the value of different imaging techniques - i.e., US, CT, and ERCP - for an early diagnosis, when a more effective (curative?) treatment can be suggested. Fifty-six cases of pancreatic cancer and 36 cases of chronic pancreatitis were evaluated. The results indicate that ERCP, with the help of statistical methods, is superior to US and CT not only in evaluating early neoplastic or inflammatory lesions, but also for their differential diagnosis. In the letter case, ERCP can sometimes be used as a valid alternative to fine-needle aspiration biopsy.

1991-01-01

443

Short-term synaptic plasticity in the auditory brain stem by using in-vivo-like stimulation parameters  

British Library Electronic Table of Contents (United Kingdom)

Reduced systems such as brain slices offer a powerful approach to study the physiology of auditory neurons in great detail. However, when studying auditory nuclei in reduced systems such as brain slices, especially highly active auditory brain stem nuclei, one has to be aware that the unphysiological lack of activity in the reduced system compared to the in-vivo situation has a number of important effects on the neurons under investigation, and thus on the data that are measured. Most importantly, the lack of chronic activity in the slice preparation has important effects on the properties of short-term plasticity of the synapses. The main purpose of this article is to discuss how spontaneous activity in auditory neurons, or the lack thereof, can affect the data measured.

2011-01-01

444

Short-term oral administration of several manganese compounds in mice: Physiological and behavioral alterations caused by different forms of manganese  

Energy Technology Data Exchange (ETDEWEB)

In Kanazawa, Japan, air pollution from a Mn treatment factory was found to affect local junior high school students, who showed reduced respiratory function relative to their exposure to Mn. The use of Mn as an antiknock ingredient in automobile fuels has recently been introduced, placing the general population at risk of chronic low-level exposure. There are few animal studies on the effects of compounds other than manganese chloride (MnCl{sub 2}). In the case of environmental pollution by Mn, the differing physiological effects of the various chemical forms of Mn must be considered. The present study therefore examined the differences in the effects of several Mn compounds on the physiology and behavior of mice by short-term oral administration.

1991-06-01

445

Septal stimulation inhibits spinal cord dorsal horn neuronal activity  

British Library Electronic Table of Contents (United Kingdom)

Deep brain stimulation (DBS) has been used for relieving chronic pain in patients that have been through other existing options. The septum has been one of the targets for such treatment. The purpose of this study was to determine the inhibitory effect of electrical stimulation in the medial septum diagonal band of broca (MSDB) on neuronal activity in the spinal cord of rats anesthetized with sodium pentobarbital. While unilaterally stimulating the MSDB, wide dynamic range neurons in the lumbar region of the spinal cord were recorded in response to graded mechanical stimulation of the hind paws (brush, pressure, and pinch). Stimulation was at 1, 5, 10, and 20V, at 100Hz, and 0.1ms duration. Significant bilateral reduction was observed in response to pressure (ipsilaterally: 0.90+/-0.05, 0....

2011-01-01

446

Roles of biomarkers in evaluating interactions among mixtures of lead, cadmium and arsenic  

British Library Electronic Table of Contents (United Kingdom)

Human exposure to environmental chemicals is most correctly characterized as exposure to mixtures of these agents. The metals/metalloids, lead (Pb), cadmium (Cd), and arsenic (As), are among the leading toxic agents detected in the environment. Exposure to these elements, particularly at chronic low dose levels, is still a major public health concern. Concurrent exposure to Pb, Cd, or As may produce additive or synergistic interactions or even new effects that are not seen in single component exposures. Evaluating these interactions on a mechanistic basis is essential for risk assessment and management of metal/metalloid mixtures. This paper will review a number of individual studies that addressed interactions of these metals/metalloids in both experimental and human exposure studies with...

2008-01-01

447

Role of MRI in the diagnostic evaluation of parotid diseases  

International Nuclear Information System (INIS)

MRI findings in 13 patients with monolateral parotid tumor were compared with US, sialographic and CT findings. MRI did not allow an accurate diagnosis in 2 patients with diffuse chronic parotitis. MRI was superior to CT in 1 case in defining the intraglandular site of the lesion, and in 2 patients in showing the extraglandular involvement. MRI proved to be superior to CT thanks to its contrast resolution and to multiplanar imaging. MRI high contrast resolution made it possible to demonstrate neoplastic lesions of 4 mm in diameter. The lesion has low signal intensity on T1-weighted images and high signal intensity on T2-weighted. Parotid tumors cannot be characterized by signal intensity alone: only morphology allows to discriminate between benign and malignant lesions. To conclude, US is a screening method, while MRI is helpful in detecting multifocal lesions and in evaluating the tumor extent.

1988-01-01

448

Radon concentration measurements in bituminous coal mines  

Energy Technology Data Exchange (ETDEWEB)

Radon measurements were carried out in Kozlu, Karadon and Uzulmez underground coal mines of Zonguldak bituminous coal basin in Turkey. Passive-time integrating method, which is the most widely used technique for the measurement of radon concentration in air, was applied by using nuclear etched track detectors (CR-39) in the study area. The radon concentration measurements were performed on a total of 42 points in those three mines. The annual exposure, the annual effective dose and lifetime fatality risk, which are the important parameters for the health of workers, were estimated based on chronic occupational exposure to the radon gas, which is calculated using UNCEAR-2000 and ICRP-65 models. The radon concentrations at several coal production faces are higher than the action level of 1000 Bq m{sup -3}. It is suggested that the ventilation rates should be rearranged to reduce the radon concentration.

2005-07-01

449

Quantitation of infectious myonecrosis virus in different tissues of naturally infected Pacific white shrimp, Litopenaeus vannamei, using real-time PCR with SYBR Green chemistry  

British Library Electronic Table of Contents (United Kingdom)

The Pacific white shrimp, Litopenaeus vannamei, is the most important shrimp species in volume in world aquaculture. However, in recent decades, outbreaks of diseases, especially viral diseases, have led to significant economic losses, threatening the sustainability of shrimp farming worldwide. In 2004, Brazilian shrimp farming was seriously affected by a new disease caused by the Infectious myonecrosis virus (IMNV). Thus, disease control based on rapid and sensitive pathogen detection methods has become a priority. In this study, a specific quantitation method for IMNV was developed using real-time PCR with SYBR Green chemistry and viral load of the principal target tissues of chronically infected animals was quantified. The quantitative analysis revealed that mean viral load ranged from ...

2011-01-01

450

Penile rehabilitation therapy with PDE-V inhibitors following radical prostatectomy: proceed with caution.  

Science.gov (United States)

Penile rehabilitation therapy following radical prostatectomy is a much debated topic. Erectile dysfunction is still a significant contributor to postoperative morbidity following radical prostatectomy, despite meticulous nerve-sparing technique. Secondary smooth muscle changes in the penis have been identified as the underlying causes of penile atrophy, veno-occlusive dysfunction, and fibrosis. Initial observations that intracavernous injection therapies used on a regular basis postoperatively resulted in improvements in the return of spontaneous erectile function led to the development of penile rehabilitation protocols. Chronic dosing of PDE-V inhibitors is now commonly used by urologists after radical prostatectomy. Despite the current enthusiasm of penile rehabilitation therapy, current scientific evidence with clinical trials is still limited. PMID:19255627

2009-01-25

451

Pain measurement: the affective dimensional measure of the McGill pain questionnaire with a cancer pain population.  

Science.gov (United States)

Two experiments used the McGill Pain Questionnaire (MPQ) to examine the affective dimension of pain in patients whose pain was secondary to malignancy. In experiment I, segregating groups of cancer patients on the basis of extreme scores (high versus low) on the MPQ failed to produce segregation on independent measures of affect and infirmity. This outcome contrasts with earlier work with chronic benign pain patients. Experiment II compared cancer pain patients matched with benign pain patients on intensity of pain report on the affective dimension of the MPQ. Cancer pain patients reported a reliably higher affective loading to their pain. These data suggest that cancer pain patients employ different criteria than benign pain patients in selecting affective pain descriptors. Possible explanations for this difference are discussed. PMID:7070825

1982-02-01

452

Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma  

British Library Electronic Table of Contents (United Kingdom)

Asthma, affecting as many as 400 million individuals worldwide, is one of the most prevalent chronic health condition in the United States. With an increasing number of patients with asthma and the frequent inability of conventional lifestyle modification and therapy to effectively control the problem, nutritional and dietary therapies are being sought. This study was undertaken to investigate the efficacy of the purple passion fruit peel (PFP) extract, a novel mixture of bioflavonoids, on asthma symptoms. Patients with asthma were studied in a 4-week randomized, placebo-controlled, double-blind trial with oral administration of PFP extract (150 mg/d) or placebo pills. The effects of PFP extract were evaluated by assessing the clinical symptoms of asthma and spirometry tests. Most clinical...

2008-01-01

453

Occupational exposure to uranium oxides (UO{sub 2} - U{sub 3}O{sub 8}) - methods and results; Etude de l'exposition industrielle a des oxydes d'uranium (UO{sub 2} - U{sub 3}O{sub 8}) - methodes et resultats  

Energy Technology Data Exchange (ETDEWEB)

Chronic exposure to uranium compounds such as UO{sub 2} and U{sub 3}O{sub 8} led to the development of a methodology, based on the recommendation of ICRP, involving four main steps: the measurement of the uranium concentration and the particle size distribution at the workstation, the assessment of physico-chemical properties of the compound, the study of in-vitro solubility using a chemical test and the monitoring of workers. Results and comments on UO{sub 2} and U{sub 3}O{sub 8} are given. (author)

1992-07-01

454

Nerve-Evoked Constriction of Rat Tail Veins Is Potentiated and Venous Diameter Is Reduced after Chronic Spinal Cord Transection  

British Library Electronic Table of Contents (United Kingdom)

Abstract Despite reduced sympathetic activity below the level of a spinal cord injury (SCI), venoconstriction during autonomic dysreflexia increases venous return to the heart. Here, contractions of isometrically mounted tail veins from rats with spinal transection at T4 performed 8???10 weeks earlier are compared with those from sham-operated rats. After SCI, lumen diameter was reduced by ?30% and the contractions evoked by electrical stimulation of the perivascular axons were larger than control. This augmentation of neurovascular transmission was not associated with enhanced sensitivity to ?-adrenoceptor agonists or to adenosine-5?-triphosphate (ATP) although contractions to depolarization with K+ were larger after SCI. The percentage reduction in nerve-evoked contraction after SCI prod...

2011-01-01

455

Mucosal Inflammation in Spondylarthritides: Past, Present, and Future  

British Library Electronic Table of Contents (United Kingdom)

Spondylarthritides (SpA) and inflammatory bowel disease (IBD) are idiopathic, chronic inflammatory disorders. Although they are very distinct and well-defined entities, there is clinical and genetic evidence supporting some degree of overlap between the pathogenesis of the two. Subclinical gut inflammation is present in up to two thirds of all SpA patients and can evolve into IBD. This subclinical gut inflammation has been shown to be strongly associated with joint inflammation, providing a clue for a common pathophysiologic background. Despite extensive research progress in the field over the past few years, many questions remain unanswered. In this paper, we focus on the clinical, genetic, and pathophysiologic overlap of SpA and IBD. Furthermore, we discuss some of the targets that may i...

2011-01-01

456

Molecular pathology of tumor-initiating cells: Lessons from Philadelphia chromosome-positive leukemia  

British Library Electronic Table of Contents (United Kingdom)

Recent improvements in cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor-initiating cells (TIC). This discovery has led to the -cancer stem cell hierarchy- concept, which holds that tumors are organized as a hierarchy of malignant tissues sustained by such TIC. However, this concept remains controversial. In this review, we examine recent advances in cancer stem cell research that have been generated from studies of Philadelphia (Ph) chromosome-positive leukemia. The abnormal Ph chromosome, which arises from a translocation creating the BCR-ABL1 fusion gene, is most commonly associated with chronic myelogenous leukemia (CML) and precursor B cell acute lymphoblastic leukemia (B-ALL). Examination of the pathophysiology ...

2011-01-01

457

Mapping of local cerebral blood flow with stable xenon-enhanced CT and the curve-fitting method of analysis  

Energy Technology Data Exchange (ETDEWEB)

A noninvasive method is described for estimating local cerebral blood flow (LCBF) and local partition coefficients by means of computed tomographic scanning during inhalation of 30% stable xenon gas in oxygen. Time-dependent xenon concentrations in arterial blood and brain tissue during the wash-in and washout phases are used to calculate partition coefficients and LCBF values by means of a least-squares curve-fitting analysis. Control values for partition coefficient and LCBF obtained from control subjects with minor head trauma in the chronic stage were compatible with those in several past reports, and reproducibility was satisfactory. The theoretic grounds underlying this new method of curve-fitting analysis are discussed.

1988-07-01

458

Mapping of local cerebral blood flow with stable xenon-enhanced CT and the curve-fitting method of analysis  

International Nuclear Information System (INIS)

A noninvasive method is described for estimating local cerebral blood flow (LCBF) and local partition coefficients by means of computed tomographic scanning during inhalation of 30% stable xenon gas in oxygen. Time-dependent xenon concentrations in arterial blood and brain tissue during the wash-in and washout phases are used to calculate partition coefficients and LCBF values by means of a least-squares curve-fitting analysis. Control values for partition coefficient and LCBF obtained from control subjects with minor head trauma in the chronic stage were compatible with those in several past reports, and reproducibility was satisfactory. The theoretic grounds underlying this new method of curve-fitting analysis are discussed.

459

Inflammatory spine disease as a cause of back pain  

International Nuclear Information System (INIS)

The aim of this review is to evaluate the role of inflammatory spine disease in patients with chronic back pain. The contribution of imaging modalities for the diagnostic evaluation of back pain is discussed. A systematic literature search based on the classification of seronegative spondyloarthropathies and rheumatoid arthritis was performed. The results of this search and the experiences in a large collective of rheumatological patients are analyzed. The prevalence of rheumatoid arthritis (1-2%) is comparable to that of spondyloarthropathies (1.9%). The etiology of these entities is not fully elucidated. Magnetic resonance imaging is increasingly used for early detection and surveillance of therapy with TNF-#alpha# antagonists. Bone marrow edema, which is only detectable with MRI, represents an early sign of inflammation. Therapy with TNF-#alpha# antagonists is based on clinical and laboratory criteria, and signs of inflammation in MRI. MRI is useful for ...

2006-06-01

460

In vitro evaluation of mineral cytotoxicity and inflammatory activity  

Energy Technology Data Exchange (ETDEWEB)

Health risks associated with inhalation of mineral dusts have been identified to a great extent through epidemiology studies, but also have been assessed by conducting subchronic and chronic inhalation studies typically on rodents. However, in vivo studies are softly, time-consuming, requiring complex technologies, and may not yield information on cellular and molecular mechanisms of response. As a result, the use of in vitro cell culture systems has played an important role in studying the toxicology of mineral dusts and providing insight into action mechanisms. This article reviews selected in vitro approaches that are used to investigate the cytotoxic and inflammatory properties of mineral particles and fibers. In addition key findings as they relate to understanding the toxicology of mineral dusts are presented. 165 refs., 1 fig., 5 tab.

1993-12-31

461

IAEA RESEARCH CONTRACTS FIRST ANNUAL REPORT. Technical reports Series No. 4  

Science.gov (United States)

Summaries are included of research contracts which expired prior to Dec. 31, 1960. The contracts were concerned with investigations of: electrophysiological responses of biological systems in nerve cells to irradiation with small doses of ionizing radiations; the mode of the protective action of certain sulfhydryl compounds against radiation effects on the synthesis of deoxyribonucleic acid, using tritium-labeled thymidine; development of a bubble chamber method of monitoring and dosimetry for Low fast neutron fluxes; effects of incorporated radioisotopes on the stability of genetic materials; interrelation of root and leaf absorption of radioisotopes in herbaceous plants; uptake of radioactive wastes by lowland rice from soils contaminated by irrigation water, and decontamination of the rice; and comparison between mutation rates induced by acute and chronic gamma irradiations. (B.O.G.)

1961-01-01

462

High-Resolution Optical Coherence Tomography Findings in Solar Maculopathy and the Differential Diagnosis of Outer Retinal Holes  

British Library Electronic Table of Contents (United Kingdom)

PurposeTo characterize the morphology of outer retinal holes caused by solar maculopathy, using spectral-domain optical coherence tomography (SD-OCT). DesignThis study is an observational case series. MethodsThe SD-OCT findings of 3 patients (6 eyes) with chronic solar maculopathy are presented. ResultsSD-OCT demonstrates a characteristic appearance of partial-thickness hole(s) in the outer retina at the fovea. In 3 of 6 eyes, there is 1 hole directly beneath the umbo. In the remaining 3 eyes, there are multifocal holes spread across the fovea. Holes in more restricted layers, as had been previously reported with time-domain OCT, were not seen. In addition, advanced visualization of SD-OCT data demonstrates a hyperreflective ring around the outer retinal hole. ConclusionsSD-OCT can be used...

2011-01-01

463

Gonadal hormone modulation of neurogenesis in the dentate gyrus of adult male and female rodents  

British Library Electronic Table of Contents (United Kingdom)

Gonadal hormones modulate neurogenesis in the dentate gyrus differentially in male and female adult rodents. Neurogenesis is comprised of at least two components: cell proliferation (the production of new cells) and cell survival (the number of new neurons that survive to maturity). Previous studies have found sex differences in the level of cell proliferation in the dentate gyrus only when comparing females in a high estrogen state to males. This review focuses on the effects of acute and chronic levels of estrogens or androgens on hippocampal neurogenesis in the adult male and female rodent. Evidence is also reviewed for the co-localization of androgen receptors and estrogen receptors (ER) with markers for cell proliferation or immature new cell survival. Briefly, evidence suggests that ...

2008-01-01

464

Global suppression of mitogen-activated ovine peripheral blood mononuclear cells by surface protein activity from Mycoplasma ovipneumoniae  

British Library Electronic Table of Contents (United Kingdom)

Mycoplasma ovipneumoniae is associated with chronic non-progressive pneumonia of sheep and goats. As with many other mycoplasmas involved in animal diseases, protective immune responses have not been achieved with vaccines, even though antibody responses can be obtained. This study focuses on characterizing the interaction of M. ovipneumoniae with ovine PBMC using carboxy-fluorescein-succinimidyl-ester (CFSE) loading and flow cytometry to measure lymphoid cell division. M. ovipneumoniae induced a strong in vitro polyclonal suppression of CD4^+, CD8^+, and B blood lymphocyte subsets. The suppressive activity could be destroyed by heating to 60^oC, and partially impaired by formalin and binary ethyleneimine treatment that abolished its viability. The activity resided on the surface-exposed m...

2010-01-01

465

Gallstones: choosing the right therapy despite vague clinical clues.  

Science.gov (United States)

Therapeutic decisions are quite clear-cut for asymptomatic gallstone disease and acute cholecystitis. However, the appropriate therapeutic course for older patients with chronic cholecystitis may be less obvious. Watchful waiting may be reasonable for patients with mild and infrequent symptoms. For healthy patients, cholecystectomy is recommended if symptoms are becoming more frequent and severe. Laparoscopy may reduce the complication rate and be safely performed even in those with underlying medical illness. Oral dissolution therapy can be attempted for qualifying symptomatic patients who are at poor surgical risk or who refuse surgery. Shock wave lithotripsy and contact dissolution therapy show some promise but are currently experimental. PMID:8339941

1993-08-01

466

Exploration of the hypothalamic?pituitary?adrenal function as a tool to evaluate animal welfare  

British Library Electronic Table of Contents (United Kingdom)

Measuring HPA axis activity is the standard approach to the study of stress and welfare in farm animals. Although the reference technique is the use of blood plasma to measure glucocorticoid hormones (cortisol or corticosterone), several alternative methods such as the measurement of corticosteroids in saliva, urine or faeces have been developed to overcome the stress induced by blood sampling itself. In chronic stress situations, as is frequently the case in studies about farm animal welfare, hormonal secretions are usually unchanged but dynamic testing allows the demonstration of functional changes at several levels of the system, including the sensitization of the adrenal cortex to ACTH and the resistance of the axis to feedback inhibition by corticosteroids (dexamethasone suppression t...

2007-01-01

467

Exogenous nicotine normalises sensory gating in schizophrenia; therapeutic implications  

British Library Electronic Table of Contents (United Kingdom)

Summary There is a current popular recognition that cigarette smoking is deleterious to health. Although this is very clearly the case for physical health, the situation regarding mental health is, however, rather more complicated. This piece concentrates on the role of smoking in schizophrenia: it is important to consider why schizophrenia, exceptionally amongst the severe and enduring mental illnesses, is associated with increased cigarette consumption. People who suffer from schizophrenia consequently have a greater risk of the complications to physical health caused by this addiction and clearly, it is important to understand why this occurs. Numerous investigators have found that both neuroleptic-naive, first-onset schizophrenics, together with chronic sufferers of the illness, consum...

2009-01-01

468

Evidence for involvement of the astrocytic benzodiazepine receptor in the mechanism of action of convulsant and anticonvulsant drugs  

Energy Technology Data Exchange (ETDEWEB)

The anticonvulsant drugs carbamazepine, phenobarbital, trimethadione, valproic acid and ethosuximide at pharmacologically relevant concentrations inhibit (/sup 3/H)diazepam binding to astrocytes in primary cultures but have much less effect on a corresponding preparation of neurons. Phenytoin as well as pentobarbital (which is not used chronically as an anticonvulsant) are equipotent in the two cell types. The convulsants picrotoxinin and pentylenetetrazol, the convulsant benzodiazepine RO 5-3663 and the two convulsant barbiturates DMBB and CHEB similarly inhibit diazepam binding to astrocytes but have little effect on neurons. On the basis of these findings it is suggested that these convulsants and anticonvulsants owe at least part of their effect to an interaction with the astrocytic benzodiazepine receptor, perhaps by interference with a calcium channel.

1988-01-01

469

Environmental Radiation Effects: A Need to Question Old Paradigms  

Energy Technology Data Exchange (ETDEWEB)

A historical perspective is given of the current paradigm that does not explicitly protect the environment from radiation, but instead, relies on the concept that if dose limits are set to protect humans then the environment is automatically protected as well. We summarize recent international questioning of this paradigm and briefly present three different frameworks for protecting biota that are being considered by the U.S. DOE, the Canadian government and the International Commission on Radiological Protection. We emphasize that an enhanced collaboration is required between what has traditionally been separated disciplines of radiation biology and radiation ecology if we are going to properly address the current environmental radiation problems. We then summarize results generated from an EMSP grant that allowed us to develop a Low Dose Irradiation Facility that specifically addresses effects of low-level, chronic irradiation on multiple levels of biological ...

2003-03-27

470

Enhanced In Vivo Function of Bioartificial Lungs in Rats  

British Library Electronic Table of Contents (United Kingdom)

BackgroundMore than 11 million Americans live with chronic lung disease; in search for an alternative to donor organs, we attempted to regenerate lungs based on perfusion decellularized lung scaffolds that can be transplanted similar to a donor organ. MethodsCadaveric rat lungs were decellularized by detergent perfusion. Resulting scaffolds were mounted in bioreactors and seeded with endothelial and fetal lung cells. Biomimetic organ culture was maintained for 7 days. Resulting bioartificial left lungs were transplanted in orthotopic position after left pneumonectomy in rats. Cadaveric left lung transplants and pneumonectomies served as controls. Blood gas analyses, compliance testing, and fluoroscopies were performed on postoperative days 1, 7, and 14. Lungs were removed for final analysi...

2011-01-01

471

Engaging both the Eagle and the Dragon: The Philippines' Precarious and Futile Attempt in Equi balancing  

British Library Electronic Table of Contents (United Kingdom)

The article examines the limits and challenges small powers face when they adjust to systemic changes. Specifically, this article discusses the Philippines' conduct of a diplomatic strategy of equi balancing between the USA and China. In this strategy, the Philippines enhances and deepens its security relations with its strategic ally, the USA and at the same time, obtains economic assistance and politico diplomatic concessions from East Asia's emergent power, China. The Philippines' diplomatic gambit, however, is restrained by its formal alliance with the USA and its chronic territorial dispute with China over the Spratly Islands. At present, several developments are undermining Manila's efforts in playing this balancing game with Washington and Beijing. These are: the Philippines' passiv...

2010-01-01

472

Effects of pre- and postnatal exposure to tritiated water for five generations on postnatal brain development  

International Nuclear Information System (INIS)

The possible long-term effects of chronic radiation exposure have been studied. Rats were given tritiated drinking water (3 #mu#Ci/ml) before and during pregnancy and thereafter continuously through five generations. The brains were studied at 30 and 120 days postnatally. Significant decreases in weight and DNA and protein contents of specific parts of the brain were found, the most pronounced decreases being in the diencephalon. The decrease in protein content were more pronounced than the decreases in DNA content; the decreases were also more pronounced at 30 days than at 120 days, and more pronounced in the fith generation than in previous generations.

473

Effects of Behet's Disease on Sexual Function and Psychological Status of Male Patients  

British Library Electronic Table of Contents (United Kingdom)

Abstract Introduction.- There are no studies on the sexual function of male patients with Behet's disease (BD), but it is probable that male sexual dysfunction may be seen in this chronic condition. Aim.- The aim of this study was to assess the effect of BD on male sexual function and psychiatric status, and to examine the relationship between sexual function and depression in this population. Methods.- Patients with a diagnosis of BD for at least one year were included in the study. The patients' age, educational level, and duration of disease were recorded. A healthy control group was selected with highly similar characteristics to the patient group. The sexual functions of the patient and the control groups were assessed using the International Index of Erectile Functions (IIEF), and th...

2011-01-01

474

Effect of an Active Abdominal Pulse Generator on Defibrillation Thresholds with a Dual-Coil, Transvenous ICD Lead System  

British Library Electronic Table of Contents (United Kingdom)

Effect of Abdominal Active Can on DFTs. Introduction: Many patients with implantable cardioverter defibrillators (ICDs) have older lead systems, which are usually not replaced at the time of pulse generator replacement unless a malfunction is noted. Therefore, optimization of defibrillation with these lead systems is clinically important. The objective of this prospective study was to determine if an active abdominal pulse generator (Can) affects chronic defibrillation thresholds (DFTs) with a dual-coil, transvenous ICD lead system. Methods and Results: The study population consisted of 39 patients who presented for routine abdominal pulse generator replacement. Each patient underwent two assessments of DFT using a step-down protocol, with the order of testing randomized. The distal right ...

2006-01-01

475

Destructive spondyloarthropathy in hemodialysis patients. Report of four cases and prospective study  

Energy Technology Data Exchange (ETDEWEB)

A destructive spondyloarthropathy is reported in four patients undergoing maintenance hemodialysis for chronic renal disease. In a separate investigation a controlled, prospective radiographic study of the cervical spine revealed this spondyloarthropathy in 4 (15%) of 26 long-term dialysis patients. A single disk level was involved in three patients, and two disc levels were involved in one patient. This spondyloarthropathy correlated with the duration of dialysis but not with the radiographic evidence of renal osteodystrophy or severity of laboratory abnormalities associated with hyperparathyroidism. Three of these four patients also had discovertebral erosions or destruction involving the lumbar spine. Cervical spine flexion views revealed evidence of ligamentous laxity or instability in three (12%) dialysis patients, all with vertebral resorption and disc space narrowing. It is postulated that this instability may contribute to the development of cervical ...

1988-04-01

476

Cost-effectiveness of educational outreach to primary care nurses to increase tuberculosis case detection and improve respiratory care: economic evaluation alongside a randomised trial  

British Library Electronic Table of Contents (United Kingdom)

Summary Objective To evaluate the cost-effectiveness of an educational outreach intervention to improve primary respiratory care by South African nurses. Methods Cost-effectiveness analysis alongside a pragmatic cluster randomised controlled trial, with individual patient data. The intervention, the Practical Approach to Lung Health in South Africa (PALSA), comprised educational outreach based on syndromic clinical practice guidelines for tuberculosis, asthma, chronic obstructive pulmonary disease, pneumonia and other respiratory diseases. The study included 1999 patients aged 15 or over with cough or difficult breathing, attending 40 primary care clinics staffed by nurses in the Free State province. They were interviewed at first presentation, and 1856 (93%) were interviewed 3 months late...

2010-01-01

477

Case?control study of knee osteoarthritis and lifestyle factors considering their interaction with physical workload  

British Library Electronic Table of Contents (United Kingdom)

Aims The aim of this study is to examine the dose?response relationships between age, ?lifestyle factors?? (body mass index, tobacco smoking, sports), and symptomatic knee osteoarthritis in a population-based case?control study. Additionally, the study aims to investigate the mode of interaction between body mass index (BMI) and physical workload (occupational kneeling/squatting and lifting/carrying of loads) with respect to the risk of symptomatic knee osteoarthritis. Methods In five orthopedic clinics and five practices, 295 male patients aged 25?70 with radiographically confirmed knee osteoarthritis associated with chronic complaints were recruited. The control group comprised 327 male control subjects. In a structured personal interview, body weight at different ages, body height, cumu...

2010-01-01

478

Assessing the effect of an antimicrobial wound dressing on biofilms  

British Library Electronic Table of Contents (United Kingdom)

ABSTRACT To date the effect of silver-containing wound dressings on biofilms, known to be present in chronic wounds, has not been determined or documented. In this current study, we aimed to determine the antimicrobial effect of a silver-containing dressing on biofilms grown in a chambered slide model. Before the addition of a wound dressing onto a 24-hour biofilm, composed of either Pseudomonas aeruginosa, Enterobacter cloacae, Staphylococcus aureus, or a mixed bacterial community, a fluorescent dye was applied. This enabled the viability of sessile bacteria to be monitored in real-time, using a rapid form of confocal laser scanning microscopy over a contact time period of 48 hours. By analyzing all the three-dimensional data generated from the confocal time-lapse sequences, 90% of all se...

2008-01-01

479

An overview of strategies to assess and rehabilitate former nuclear test sites. Keynote address  

International Nuclear Information System (INIS)

Since the publication by the International Commission on Radiological Protection of revised recommendations which set out some general principles for intervention, some ideas have emerged which address interventions in the case of chronic exposure from contaminated lands. In the past there have been interventions proposed or carried out to rehabilitate land contaminated during the era of atmospheric nuclear weapon testing. Some of these interventions are reviewed in the context of these ideas and it is concluded that, by and large, reasonable outcomes have been achieved. The concept of a 'generic action level' (an effective dose of the order of 10 mSv#centre dot#a"-"1 to representative individuals in the critical group) may be useful in future to aid decision makers in determining whether intervention is appropriate. (author)

480

An integrated genome research network for studying the genetics of alcohol addiction  

British Library Electronic Table of Contents (United Kingdom)

Abstract Alcohol drinking is highly prevalent in many cultures and contributes to the global burden of disease. In fact, it was shown that alcohol constitutes 3.2% of all worldwide deaths in the year 2006 and is linked to more than 60 diseases, including cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders, injuries and foetal alcohol syndrome. Alcoholism, which has been proven to have a high genetic load, is one potentially fatal consequence of chronic heavy alcohol consumption, and may be regarded as one of the most prevalent neuropsychiatric diseases afflicting our society today. The aim of the integrated genome research network -Genetics of Alcohol Addiction--which is a German inter-/trans-disciplinary life science consortium consisting of molecular biologists,...

2010-01-01

481

An immunohistochemical study in cases with usual and unusual clinicopathological findings of canine visceral leishmaniosis  

British Library Electronic Table of Contents (United Kingdom)

The present study describes pathologic findings and immunohistochemical diagnosis of canine visceral leishmaniasis (CVL) in 22 dogs who died naturally in the Aegean region of Turkey. At necropsy, lymphadenomegaly, hepatosplenomegaly, hepatic, and nephrosclerotic lesions were conspicuous. Histopathologically, chronic inflammatory reactions of the spleen, lymph nodes, bone marrow, liver, and skin were marked findings. Cytological and histological examinations showed macrophages loaded with Leishmania amastigotes in these organs. Immunohistochemistry revealed that immunolabeling of amastigotes and/or parasite antigen, especially in the lymph nodes, spleen, bone marrow, liver, and skin, and occasionally, in the kidneys, intestines and lungs. Our laboratory results showed that immunohistochemis...

2011-01-01

482

Adverse cutaneous reactions secondary to tyrosine kinase inhibitors including imatinib mesylate, nilotinib, and dasatinib  

British Library Electronic Table of Contents (United Kingdom)

Abstract Imatinib mesylate is the first of a novel group of drugs that specifically target protein tyrosine kinases, which are central to the pathogenesis of human cancer. It has been approved for the treatment of chronic myeloid leukemia and gastrointestinal stromal tumor and has been found efficacious in other neoplastic diseases. Nilotinib and dasatinib, a second-generation of tyrosine kinase inhibitors (TKIs), were developed in response to findings of emerging imatinib resistance or intolerance to the drug. Cutaneous reactions are the most common nonhematologic side effect of these drugs, and their management is challenging especially in the absence of alternative anticancer agents. The present review focuses on the clinical characteristics and the hypothesized molecular pathogenesis o...

2011-01-01

483

Adult Attention-Deficit/Hyperactivity Disorder Treatment and Cardiovascular Implications  

British Library Electronic Table of Contents (United Kingdom)

Attention-deficit/hyperactivity disorder (ADHD) is a chronic neurobehavioral disorder afflicting adults worldwide. This article is an update on the evidence supporting medications for adult ADHD, with particular emphasis on cardiovascular implications. Relevant clinical literature was sought using PubMed searches, with an emphasis on new reports from April 2009 to April 2011. This review describes the efficacy and general tolerability of stimulant and nonstimulant medications for adults with ADHD as seen in contemporary clinical trials. Cardiovascular response to medications for ADHD is primarily seen in heart rate and blood pressure elevations, while less is known about the etiology of rare cardiovascular events or long-term sequelae. Further research is indicated to delineate clinical an...

2011-01-01

484

A prospective randomised open label study to evaluate the potential of a new silver alginate/carboxymethylcellulose antimicrobial wound dressing to promote wound healing  

British Library Electronic Table of Contents (United Kingdom)

The aim of this study was to observe both the clinical signs and symptoms of wounds at risk of infection, that is critically colonised (biofilm infected) and antimicrobial-performance of an ionic silver alginate/carboxymethylcellulose (SACMC) dressing, in comparison with a non silver calcium alginate fibre (AF) dressing, on chronic venous leg and pressure ulcers. Thirty-six patients with venous or pressure ulcers, considered clinically to be critically colonised (biofilm infected), were randomly chosen to receive either an SACMC dressing or a non silver calcium AF dressing. The efficacy of each wound dressing was evaluated over a 4-week period. The primary study endpoints were prevention of infection and progression to wound healing. The SACMC group showed a statistically significant (P = ...

2010-01-01

485

Validation of flux mapping system (FMS) of TAPP-4 with TRIVENI  

International Nuclear Information System (INIS)

The reactor core of TAPP-3 and 4 is divided into 14 power zones for spatial power control. Corresponding to each zone is a light water zonal compartment. The 14 ZCCs are located in two radial planes, each containing 7 ZCCs. For each zone, power measurement is carried out using three cobalt Self Powered Neutron Detectors (SPNDs) at appropriate locations close to the respective ZCC. Since the zone power as obtained by the true average of the healthy zone control detector (ZCD) readings belonging to a particular zone may not correspond to its actual power because these 3 detectors per zone, measure only point fluxes but the zone extends over a large core region. Therefore accurate estimation of zone power calibration factors is required to estimate the zone powers and also to provide effective spatial power control to avoid the xenon induced spatial power oscillations in large PHWRs like 540 MWe Reactor. This accurate calculation of zone power is carried out by FMS ...

2006-11-13

486

Tumour control probability (TCP) for non-uniform activity distribution in radionuclide therapy  

Energy Technology Data Exchange (ETDEWEB)

Non-uniform radionuclide distribution in tumours will lead to a non-uniform absorbed dose. The aim of this study was to investigate how tumour control probability (TCP) depends on the radionuclide distribution in the tumour, both macroscopically and at the subcellular level. The absorbed dose in the cell nuclei of tumours was calculated for {sup 90}Y, {sup 177}Lu, {sup 103m}Rh and {sup 211}At. The radionuclides were uniformly distributed within the subcellular compartment and they were uniformly, normally or log-normally distributed among the cells in the tumour. When all cells contain the same amount of activity, the cumulated activities required for TCP = 0.99 (A-tilde{sub TCP=0.99}) were 1.5-2 and 2-3 times higher when the activity was distributed on the cell membrane compared to in the cell nucleus for {sup 103m}Rh and {sup 211}At, respectively. TCP for {sup 90}Y was not affected by different radionuclide distributions, whereas for {sup 177}Lu, it was slightly ...

2008-08-21

487

Thermal performance of automotive aluminium plate radiator  

Energy Technology Data Exchange (ETDEWEB)

The thermal performance of an automotive radiator plays an important role in the performance of an automobile's cooling system and all other associated systems. For a number of years, this component has been given little attention with very little changing in its manufacturing cost, operation and geometry. As opposed to the old tubular heat exchanger configurations used in automotive radiators, plate heat exchangers currently form the backbone of today's process industry with their advanced performance reaching levels the designers of tubular heat exchangers can only dream of. The aluminium roll-bonding technique widely used in manufacturing the cooling compartments for domestic refrigeration units is one of the cheapest methods for heat exchanger manufacturing. Using this technique, it is possible to manufacture a wide range of heat exchanger configurations that can help augment heat transfer whilst reducing pressure drops. CFD results obtained ...

2005-06-01

488

Temperature-induced fusion of small unilamellar vesicles formed from saturated long-chain lecithins and diheptanoylphosphatidylcholine  

Energy Technology Data Exchange (ETDEWEB)

Small unilamellar vesicles which form when gel-state long-chain phosphatidylcholines are mixed with micellar short-chain lecithins undergo an increase in size as the long-chain species melts to its liquid-crystalline form. Analysis of the vesicle population with quasi-elastic light scattering shows that the particle size increases from 90-A radius to greater than 5000-A radius. Resonance energy transfer experiments show total mixing of lipid probes with unlabeled vesicles only when the Tm of the long-chain phosphatidylcholine is exceeded. This implies that the large size change represents a fusion process. Aqueous compartments are also mixed during this transition. 31P NMR analysis of the vesicle mixtures above the phase transition shows a great degree of heterogeneity with large unilamellar particles coexisting with oligo- and multilamellar structures. Upon cooling the vesicles below the Tm, the original size distribution (e.g., small unilamellar vesicles) is ...

1989-10-03

489

Simulation of CO{sub 2} budget and ecological implications of sugi (cryptomeria japonica) man-made forests in Japan  

Energy Technology Data Exchange (ETDEWEB)

A compartment model, including removal of organic matter in a forest ecosystem, is developed to describe matter cycling and net CO{sub 2} flux of the ecosystem especially of managed forests. The model consists of five carbon stocks: atmosphere, foliage, woody matter, underground matter, and dead organic matter in the soil. Employing appropriate values of ecophysiological parameters in the model and simulation of man-made sugi (Cryptomeria japonica D. Don) plantation forests shows that these forests have high growth potential with a maximum total phytomass of over 750 t ha{sup -1} in dry matter basis. When the typical pattern of thinning regime for sugi plantation forests in Japan is applied to the present model, the simulated forest biomass developments compare well with mensuration data from various forestry sites. The CO{sub 2} balance between the sugi forest ecosystem and the atmosphere reveals a net CO{sub 2} fixation of 49.38 million ton CO{sub 2} year{sup -1} ...

1998-09-01

490

Reservoir characterization of the Ordovician Red River Formation in southwest Williston Basin Bowman County, ND and Harding County, SD  

Energy Technology Data Exchange (ETDEWEB)

This topical report is a compilation of characterizations by different disciplines of the Red River Formation in the southwest portion of the Williston Basin and the oil reservoirs which it contains in an area which straddles the state line between North Dakota and South Dakota. Goals of the report are to increase understanding of the reservoir rocks, oil-in-place, heterogeneity, and methods for improved recovery. The report is divided by discipline into five major sections: (1) geology, (2) petrography-petrophysical, (3) engineering, (4) case studies and (5) geophysical. Interwoven in these sections are results from demonstration wells which were drilled or selected for special testing to evaluate important concepts for field development and enhanced recovery. The Red River study area has been successfully explored with two-dimensional (2D) seismic. Improved reservoir characterization utilizing 3-dimensional (3D) and has been investigated for identification of structural and ...

1998-07-01

491

Research document no. 24. The integration of european electric markets: from the national markets juxtaposition to the establishment of a regional market; Cahier de recherche no. 24. L'integration des marches electriques europeens: de la juxtaposition de marches nationaux a l'etablissement d'un marche regional  

Energy Technology Data Exchange (ETDEWEB)

After the transcription of the electricity directive in national legislations, the European electricity market appears to be a vast set of juxtaposed markets which are weakly connected at the level of their wholesale contracts compartment. Referring to the technological peculiarities of electricity as a commodity, the paper identifies the direct conditions of regional integration of the electricity markets, those which would favour cross-border trade and allow to be near the normal functioning of a regional commodity market. The infrastructure network dependence and the need of a stringent technical coordination necessitate to unify the operation of the different systems and the rules of access, or at the least to come near this unification by strong coordination. A second major condition, which is not fully debated, is the increasing connexion of short-term markets, via daily physical trade and emergence of a European financial market, which could trade various ...

2000-11-01

492

Mitochondrial sequestration of BCECF after ester loading in the giant alga Chara australis.  

Science.gov (United States)

Ratiometric fluorescent dyes are often used to monitor free ion concentrations in vivo, especially in cells that are recalcitrant to transformation with genetically encoded fluorescent markers. Although intracellular dye distributions are often found to be cytosolic, dye localisation has often not been examined in detail. We began exploring the use of BCECF (2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein) to monitor pH in the giant alga Chara australis and discovered that younger leaf cells could be loaded using the acetoxymethyl ester of BCECF. However, we were puzzled to find in microphotometric measurements that the fluorescence ratio appeared insensitive to manipulations affecting cytosolic pH. Confocal imaging of C. australis cells loaded with BCECF showed an accumulation of the dye in two locations: (1) on the outside of the chloroplasts in irregularly shaped stationary bodies; (2) within 1-1.5 mum structures that moved rapidly with the pericellular cytoplasmic streaming. ...

2007-12-19

493

Improvement of bioprocess monitoring: development of novel concepts.  

Science.gov (United States)

The advancement of bioprocess monitoring will play a crucial role to meet the future requirements of bioprocess technology. Major issues are the acceleration of process development to reduce the time to the market and to ensure optimal exploitation of the cell factory and further to cope with the requirements of the Process Analytical Technology initiative. Due to the enormous complexity of cellular systems and lack of appropriate sensor systems microbial production processes are still poorly understood. This holds generally true for the most microbial production processes, in particular for the recombinant protein production due to strong interaction between recombinant gene expression and host cell metabolism. Therefore, it is necessary to scrutinise the role of the different cellular compartments in the biosynthesis process in order to develop comprehensive process monitoring concepts by involving the most significant process variables and their ...

2006-05-22

494

Improved recovery demonstration for Williston Basin carbonates. Final report  

Science.gov (United States)

The purpose of this project was to demonstrate targeted infill and extension drilling opportunities, better determinations of oil-in-place, and methods for improved completion efficiency. The investigations and demonstrations were focussed on Red River and Ratcliffe reservoirs in the Williston Basin within portions of Montana, North Dakota and South Dakota. Both of these formations have been successfully explored with conventional 2-dimensional (2D) seismic. Improved reservoir characterization utilizing 3-dimensional (3D) seismic was investigated for identification of structural and stratigraphic reservoir compartments. These seismic characterizations were integrated with geological and engineering studies. The project tested lateral completion techniques, including high-pressure jetting lance technology and short-radius lateral drilling to enhance completion efficiency. Lateral completions should improve economics for both primary and secondary oil where low ...

1998-07-01

495

Heat management - a technique for resolving the conflicting aims between fuel consumption and comfort; Waermemanagement - ein Werkzeug zur Loesung der Zielkonflikte zwischen Verbrauch und Komfort  

Energy Technology Data Exchange (ETDEWEB)

In view of current trends in motor car development, the author investigates the increasing conflict between higher comfort and lower fuel consumption. The conflict results mainly from insufficient cooling water heating with consumption-optimized engines. So far, it was never necessary to analyze heat flow after cold starting and heat-up of the powertrain, to develop strategies for heat storage and distribution, to remove heat sinks and to use components multifunctionally. The contribution shows that a general heat management strategy for the whole vehicle will result in high potential fuel savings and improved thermal comfort. Using the example of a latent heat store, heating strategies for the engine and transmission system on the one hand and the passenger compartment on the other hand are developed, and the advantages are presented in detail. [German] Abgeleitet aus den Trends in der Fahrzeugentwicklung wird auf den immer staerker werdenden Konflikt zwischen den ...

1999-07-01

496

Experimental investigation of mixed convection heat transfer caused by forced-jets in large enclosure  

Energy Technology Data Exchange (ETDEWEB)

This research investigates experimentally mixed convection and heat transfer augmentation by forced jets in a large enclosure, at conditions simulating those of actual passive containment cooling systems and scales approaching those of actual containment buildings or compartments. The experiment was designed to measure the key parameters governing the heat transfer augmentation by forced jets and investigate the effects of geometric factors, including the jet diameter, jet injection orientation, interior structures, and enclosure aspect ratio. The tests cover a variety of injection modes leading to flow configurations of interest that contribute to reveal the nature of mixing and stratification phenomena in the containment under accident conditions of interest. The heat transfer of mixed convection can be predicted to be controlled by jet Archimedes number and geometric factors. Using a combining rule for mixed convection and appropriate forced and natural ...

2004-07-01

497

Dose coefficients for intakes of radionuclides via contaminated wounds.  

Science.gov (United States)

The NCRP Wound Model, which describes the retention of selected radionuclides at the site of a contaminated wound and their uptake into the transfer compartment, has been combined with the ICRP element-specific systemic models for those radionuclides to derive dose coefficients for intakes via contaminated wounds. These coefficients can be used to generate derived regulatory guidance (i.e., the activity in a wound that would result in an effective dose of 20 or 50 mSv, or in some cases, a organ-equivalent dose of 500 mSv) and clinical decision guidance (i.e., activity levels that would indicate the need for consideration of medical intervention to remove activity from the wound site, administration of decorporation therapy or both). Data are provided for 38 radionuclides commonly encountered in various activities such as nuclear weapons, fuel fabrication or recycling, waste disposal, medicine, research, and nuclear power. These include 3H, 14C, 32P, 35S, 59Fe, ...

2011-05-01

498

Current status of siting a new near surface repository in Romania  

International Nuclear Information System (INIS)

Full text: The site selection process for a near surface repository dedicated for the radioactive waste resulted from the Cernavoda NPP operation and decommissioning started early in 90's. Each site selection stage included the collection of data from specific field and laboratory works as well as the appropriate safety performance evaluation. In order to assess/confirm the performance of the natural barrier of the Saligny site, the radionuclide concentration in the disposal system compartments has been evaluated, as complementary safety indicator of repository. The siting process was made in accordance with national and international regulations and standards and using a conceptual design similar to those used at L'Aube (France), ElCabril (Spain) or Mohovce (Slovak Republic). ANDRAD, the Romanian waste management organization that has continued the siting process in the last three years applied and obtained a partial siting license from CNCAN in 2008. In 2009, ...

2009-05-27

499

Cellular dosimetry: Absorbed fractions for monoenergetic electron and alpha particle sources and S-values for radionuclides uniformly distributed in different cell compartments  

Energy Technology Data Exchange (ETDEWEB)

The importance of cellular dosimetry in both diagnostic and therapeutic nuclear medicine is becoming increasingly recognized. Experimental range-energy relations for electrons and alpha particles, along with derived geometric reduction factors, are used to calculate cellular absorbed fractions for these radiations. The resulting absorbed fractions are employed to calculate cellular S-values for several radionuclides. Cellular absorbed fractions for monoenergetic electron sources with energies ranging from 0.1 keV to 1 MeV, distributed uniformly in the source region, are calculated for several target {l_arrow} source combinations including cell{l_arrow}cell, cell{l_arrow}cell surface, nucleus{l_arrow}nucleus, nucleus {l_arrow}cytoplasm and nucleus {l_arrow}cell surface. Similar data are also provided for monoenergetic alpha particle sources with energies ranging from 3 to 10 MeV. S-values are also conveniently tabulated for {sup 32}P, {sup 35}S, {sup 86}Rb, {sup 89}Sr, {sup 90}Y, {sup ...

1994-02-01

500

A case of wound intake of plutonium isotopes and 241Am in a human: application and improvement of the NCRP wound model.  

Science.gov (United States)

Plutonium isotopes (239Pu and 238Pu, and 241Am) with a total activity of 269 kBq were accidentally deposited in a puncture wound of the right index finger of a nuclear worker at the Mayak Production Association. Tissues surrounding the wound site contaminated with radionuclides were excised 4.5 h after the injury. Residual contamination within the wound amounted to 0.05% of the initial contamination. The 10-d therapy with CaNa3-diethylene triamine pentaacetate acid (CaNa3-DTPA) was performed in parallel with in vivo measurements of the wound site and daily urine bioassays. The wound intake of radionuclides was consistent with two forms of radioactive materials detected within the wound site, i.e., soluble compounds and a large fragment, which was completely removed by excision. On day 9 after the injury, the clearance rate from the wound site was 1.8 times higher than the rate predicted by the National Council on Radiation Protection and Measurements (NCRP) model for soluble compounds ...

2010-10-01