Science.gov (United States)

This cost-effectiveness analysis supports the proposed effluent limitations guidelines and standards for the Metal Products and Machinery Industry (MP and M) Phase I Industry. The report assesses the cost-effectiveness of five regulatory options for indir...

Energy Technology Data Exchange (ETDEWEB)

Concern for the environment and cost reduction are driving forces for a broad effort in government and the private sector to develop new, more cost-effective technologies for characterizing, monitoring and remediating environmental sites. Secondary goals of the characterization, monitoring and remediation (CMR) activity are: minimize secondary waste generation, minimize site impact, protect water tables, and develop methods/strategies to apply new technologies. The Sandia National Laboratories (SNL) project in directional boring for CMR of waste sites with enhanced machinery from the underground utility installation industry was initiated in 1990. The project has tested a variety of prototype machinery and hardware built by the industrial partner, Charles Machine Works (CMW), and SNL at several sites (Savannah River Site (SRS), Hanford, SNL, Kirtland AFB (KAFB), CMW), successfully installed usable horizontal environmental test wells at SRS and ...

CERN Multimedia

View of construction of endcap carts in Hudong Heavy Machinery (HHM) in Shanghai, China.

Energy Technology Data Exchange (ETDEWEB)

Purified protein kinase C (C-kinase) from guinea pig pancreas and rat brain stimulated adenylate cyclase activity in purified rat adipocyte membranes. Cyclase stimulation occurred over 100 to 1000 mU/ml of C-kinase activity, required greater than 10 ..mu..M calcium, proceeded without a lag, was not readily reversible, and required no exogenous phospholipid. Moreover, C-kinase inhibitors, such as chlorpromazine and palmitoyl carnitine, inhibited selectively adenylate cyclase which was activated by C-kinase and calcium. Depending on assay conditions, 10 nM 12-0-tetradecanoylphorbol-13-acetate (TPA) either enhanced or was required for kinase action on cyclase. Also, TPA plus calcium promoted the quantitative association of C-kinase with membranes. Adenylate cyclase activation by C-kinase was seen both in the presence and absence of exogenous GTP, indicating that the kinase effect does not result from an action on the ...

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

The hypothesis that intracellular Ca/sup 2 +/ is an essential component of the intracellular mechanism of insulin action in the adipocyte was evaluated. Cells were loaded with the Ca/sup 2 +/ chelator quin-2, by preincubating them with quin-2 AM, the tetrakis(acetoxymethyl) ester of quin-2. Quin-2 loading inhibited insulin-stimulated glucose transport without affecting basal activity. The ability of insulin to stimulate glucose uptake in quin-2-loaded cells could be partially restored by preincubating cells with buffer supplemented with 1.2 mM CaCl/sub 2/ and the Ca/sup 2 +/ ionophore A23187. These conditions had no effect on basal activity and omission of CaCl/sub 2/ from the buffer prevented the restoration of insulin-stimulated glucose uptake by A23187. Quin-2 loading also inhibited insulin-stimulated glucose oxidation and the ability of insulin to inhibit cAMP-stimulated lipolysis without affecting their basal activities. Incubation of cells with 100 ..mu..M quin-2 or quin-2 AM had ...

KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

The objective of this study is to establish a construction plan for vibration analysis system of HANARO's rotating machinery. To achieve this purpose, as a first step, the references related to the vibration analysis system for the rotating machinery were investigated. In addition, to verify the possibility of condition monitoring of the pumps, vibration signals obtained from the vibration monitoring system were analyzed. The results show that using the accelerometers mounted on the bearing locations of the pumps can monitor the current status of the pump such as unbalance, misalignment, and bearing condition. Based on the results of this study, the construction plans for the vibration analysis system of HANARO have been established. The hardware of the vibration analysis system will be installed by the end of this year. It is expected that the developed vibration analysis system can be utilized for the realization of the preventive ...

Energy Technology Data Exchange (ETDEWEB)

Vibration of machinery plays an important role in preventive maintenance programs of machinery. It can be applied in different phases ranging from simple to computerized programs. The advantages of applying machine condition monitoring programs are numerous since vibration measurement and analysis leads to the early detection of component deterioration. The cost, savings and some details of the vibration preventive maintenance program are discussed.

International Nuclear Information System (INIS)

Neuron-restrictive silencer factor (NRSF) binds its consensus element to repress the transcription of various genes. The dominant-negative form (dnNRSF) has a hypertrophic effect on cardiogenesis through an unidentified mechanism. We examined the involvement of transient receptor potential (TRP) channel proteins, using transgenic mice overexpressing dnNRSF (dnNRSF mice). Electrophoretic mobility-shift assays revealed an interaction between NRSF and a neuron-restrictive silencer element-like sequence in intron 4 of TRPC1 genomic DNA. According to RT-PCR and Western analyses, TRPC1 was up-regulated in dnNRSF mouse heart. Transient overexpression of TRPC1 in HEK 293T cells increased the activity of the nuclear factor in activated T cells (NFAT) promoter and stimulated store-operated Ca"2"+ channel (SOCC)-mediated Ca"2"+ entry. Transfection of TRPC1 into primary cardiomyocytes increased NFAT activity, indicating a major role for TRPC1 in NFAT activation. Our findings strongly suggest that ...

Energy Technology Data Exchange (ETDEWEB)

Heterochromatin constitutes a significant portion of the genome in higher eukaryotes; approximately 30% in Drosophila and human. Heterochromatin contains a high repeat DNA content and a low density of protein-encoding genes. In contrast, euchromatin is composed mostly of unique sequences and contains the majority of single-copy genes. Genetic and cytological studies demonstrated that heterochromatin exhibits regulatory roles in chromosome organization, centromere function and telomere protection. As an epigenetically regulated structure, heterochromatin formation is not defined by any DNA sequence consensus. Heterochromatin is characterized by its association with nucleosomes containing methylated-lysine 9 of histone H3 (H3K9me), heterochromatin protein 1 (HP1) that binds H3K9me, and Su(var)3-9, which methylates H3K9 and binds HP1. Heterochromatin formation and functions are influenced by HP1, Su(var)3-9, and the RNA interference (RNAi) pathway. My thesis project ...

UK PubMed Central (United Kingdom)

Taste cells use multiple signaling mechanisms to generate appropriate cellular responses to discrete taste stimuli. Some taste stimuli activate G protein coupled receptors (GPCRs) that cause calcium...Full Text Available

UK PubMed Central (United Kingdom)

Background:The cardiac sodium–calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance of calcium homeostasis in the heart. Since heart failure...Full Text Available

UK PubMed Central (United Kingdom)

Calcium requirements of North American adolescents were set at 1300 mg/day based on data from white girls. Calcium requirements for Asian-American adolescents have not been studied. Using metabolic...Full Text Available

UK PubMed Central (United Kingdom)

AbstractWe propose a mechanism for the formation of membrane oscillations and traveling waves, which arise due to the coupling between the actin cytoskeleton and the calcium flux through...Full Text Available

Science.gov (United States)

Table of Contents: Overview of Organization and Contents of Document; Analytical Data Collection Efforts and Definition of Options; Description of Data Conventions; Statistical Methodology: Modified Delta-Lognormal Model; Estimation Under the Modified Del...

UK PubMed Central (United Kingdom)

The Dot/Icm-translocated Ankyrin B (AnkB) F-box effector of Legionella pneumophila is essential for intra-vacuolar proliferation and functions as a platform for the docking of polyubiquitinated...Full Text Available

UK PubMed Central (United Kingdom)

The Dot/Icm type IV translocated Ankyrin B (AnkB) effector of Legionella pneumophila is modified by the host prenylation machinery that anchors it into the outer leaflet of the Legionella-containing...Full Text Available

UK PubMed Central (United Kingdom)

Recent studies have indicated that the DNA replication machinery is coupled to silencing of mating-type loci in the budding yeast Saccharomyces cerevisiae, and a similar silencing mechanism...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

KoreaScience (Korea)

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International Nuclear Information System (INIS)

Short communication.

KoreaScience (Korea)

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KoreaScience (Korea)

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KoreaScience (Korea)

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Energy Technology Data Exchange (ETDEWEB)

To apply the CO{sub 2} absorber at about 1000{sup o}C for integrated coal gasification combined cycle (IGCC) furnace, the reactions of calcium oxide and CO{sub 2} at high temperatures was examined. Calcium carbonate reacts with sodium hydrogen carbonate below 200{sup o}C and forms sodium-calcium complex carbonate. The sodium-calcium complex carbonate melts at 813{sup o}C, and the carbon dioxide absorption and discharge reversible reactions of calcium-oxide takes place via liquid at around 1000{sup o}C. Sintering of calcium oxide at high temperature has been successfully avoided by the addition of sodium.

International Nuclear Information System (INIS)

We studied the effect of extracellular Ca"2"+ concentration ([Ca"2"+]_e) on adipocyte differentiation. Preadipocytes exposed to continuous [Ca"2"+]_e higher than 2.5 mmol/l accumulated little or no cytoplasmic lipid compared to controls in 1.8 mmol/l [Ca"2"+]_e. Differentiation was monitored by Oil Red O staining of cytoplasmic lipid and triglyceride assay of accumulated lipid, by RT-PCR analysis of adipogenic markers, and by the activity of glycerol-3-phosphate dehydrogenase (GPDH). Elevated [Ca"2"+]_e inhibited expression of peroxisome proliferator-activated receptor #gamma#, CCAAT/enhancer binding protein #alpha#, and steroid regulatory binding element protein. High [Ca"2"+]_e significantly inhibited differentiation marker expression including adipocyte fatty acid binding protein, and GPDH. The decrease in Pref-1 expression that accompanied differentiation also was prevented by high [Ca"2"+]_e. Treatment of 3T3-L1 cells with high [Ca"2"+]_e did not significantly ...

UK PubMed Central (United Kingdom)

BackgroundInferring regulatory interactions between genes from transcriptomics time-resolved data, yielding reverse engineered gene regulatory networks, is of paramount importance...Full Text Available

International Nuclear Information System (INIS)

As the new entrants in the global nuclear construction market are increasing and the establishment of an effective and sustainable regulatory infrastructure becomes more important, they have requested international assistance from the international nuclear communities with mature nuclear regulatory programmes. It needs to optimize the use of limited resources from regulatory organization providing support to regulatory infrastructure of new comers. This paper suggests the resource portfolio concept like a GE/Mckinsey Matrix used in business management and tries to apply it to the current needs considered in the regulatory support program in Korea as the case study

UK PubMed Central (United Kingdom)

Skeletal muscle uses calcium as a second messenger to respond and adapt to environmental stimuli. Elevations in intracellular calcium levels activate calcineurin, a serine/threonine phosphatase, resulting...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundCalcium signaling plays an important role in B lymphocyte survival and activation, and is critically dependent on the inositol-1,4,5-tris-phosphate-induced...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundCalcium homeostasis is a known target of several environmental toxicants including lead and mercury.ObjectiveOur goal was to determine...Full Text Available

UK PubMed Central (United Kingdom)

Objectives To assess the effectiveness of calcium supplementation for improving bone mineral density in healthy children and to determine if any effect is modified by other factors and...Full Text Available

UK PubMed Central (United Kingdom)

Calcium, vitamin D, exposure to sunshine, and vitamin D receptor (VDR) genotypes have been associated rectal cancer. We used data from 750 rectal tumors and 1,205 population-based...Full Text Available

UK PubMed Central (United Kingdom)

Assessment of the regulation of plant metabolism by the calcium ion requires a knowledge of its intracellular levels and dynamics. Technical problems have prevented direct measurement of the concentration...Full Text Available

UK PubMed Central (United Kingdom)

Regulatory T cells are proposed to play a central role in the maintenance of immunological tolerance in the periphery, and studies in many animal models demonstrate their capacity to inhibit inflammatory...Full Text Available

KoreaScience (Korea)

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Science.gov (United States)

... interactive surfaces and interfaces, and 3) the more complex a ... carbonate or calcium phosphate with a thin interface ... diameter) for nerve prosthesis. ...

Energy Technology Data Exchange (ETDEWEB)

Ways of reducing energy consumption in plastics processing are examined. Examples are given which illustrate how the awareness of everyone in the company to energy saving is essential with particular reference to switching arrangements to ensure such things as lights, machinery, compressed air systems are switched off when not needed or run at a lower level where appropriate. An understanding of the various elements of the electricity bill can inform a company`s planning of its operations to take advantage of lower tariffs. Machinery selection both with regard to efficiency of processing, quality of engineering and appropriate size can achieve significant savings and attention to maintenance is important. Fundamental to all aspects of energy saving is the monitoring of energy usage to identify where savings can be made and to evaluate the effectiveness of any measures taken. (UK)

Science.gov (United States)

Gas contaminated with at least one noxious component, such as SO/sub 2/, HF or NOx, is scrubbed with a clear, calcium-containing, initially-basic washing liquid which also comprises the anion of a strong inorganic acid, that of a polybasic carboxylic acid and, optionally, that of a monobasic carboxylic acid. Apparatus is provided for scrubbing the gas, oxidizing produced calcium bisulfite to calcium sulfate, separating out and removing solids, and recirculating clarified liquid for scrubbing contaminated gas.

Energy Technology Data Exchange (ETDEWEB)

X-ray diffraction, infrared spectroscopy, thermal analysis, scanning electron microscopy, and particle size analysis were used to characterize the product of the thiosulfate process. It was found to consist of a mixture of a solid solution of calcium sulfate in calcium sulfite hemihydrate, calcium sulfate dihydrate, and calcium carbonate. Reactions taking place on heating the byproduct were identified in oxidizing and reducing atmospheres. Pure calcium sulfite hemihydrate as well as solid solutions of CaSO[sub 4] in CaSO[sub 3] [center dot] (1/2)H[sub 2]O with different sulfate concentrations were synthesized in the laboratory. Thermal analyses of pure solid solutions proved that the higher the sulfate content, the higher is the dehydration temperature. Accordingly, taking SO[sub 4][sup 2[minus

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

Energy Technology Data Exchange (ETDEWEB)

Water-assisted mining machinery is beginning to be considered in the US, although it has been in use in Europe for some time. A waterjet roof bolter is currently under test and should greatly increase drilling rate with longer bit life and no dust. Water-assisted roadheaders and longwall winning machines under development in Europe and the US are described.

Energy Technology Data Exchange (ETDEWEB)

The four mines supplying the Sasol-2 plant at Secunda, South Africa are approaching their full production potential of 29 million t/year. Current production is 27.7 million t/year of coal for gasification and steam raising. Three mining methods are employed: bord and pillar, longwall and continuous mining. Details are given of the mining operations and machinery. A 43 km overland conveyor transports the coal to the Sasol plant stockpile.

Energy Technology Data Exchange (ETDEWEB)

The paper describes a way to control methane that is almost self-sufficient. The Methane Buster extracts methane from longwall mines. The machinery can run virtually unattended and is fuelled by a small proportion of the methane that it extracts. The most popular model is the size of a car and weighs 3000 lbs. With pump inlet sizes varying from 6 to 24 ins. The pumps can handle up to 30,000 CFM. 3 photos.

International Nuclear Information System (INIS)

The present Annual Report of Activities of the Nuclear Regulatory Authority (ARN), prepared regularly from the creation as independent institution, describes across tree parts and seven annexes the activities developed by the organism during 2007. The main topic are: the organization and the activity of the ARN; the regulatory standards; the licensing and inspection of nuclear power plants and critical facilities; the emergency systems; the occupational surveillance; the environmental monitoring; improved organizational. Also, this publication have annexes with the following content: regulatory documents; inspections to medical, industrial and training installations; regulatory guides; measurement and evaluation of the drinking water of Ezeiza.

Science.gov (United States)

A method of treating final products from a flue gas desulfurization. The flue gas desulfurization is carried out by the absorption of sulfur oxide in a spray dryer with a suspension which contains lime, or in a reactor with a dry, fine-grained, absorbent which contains lime. Prior to desulfurization, the fly ash carried along by the flue gas which is to be desulfurized is separated entirely, partially, or not at all from the flue gas, and the final products from the flue gas desulfurization, prior to any further treatment thereof, amount to 1-99% by weight, preferably 1-70% by weight, of fly ash, and 1-99% by weight, preferably 30-99% by weight, of the sum of the desulfurization products, preferably calcium sulfite hemihydrate, and/or calcium sulfite, and/or calcium sulfate dyhydrate, and/or calcium sulfate hemihydrate, and/or calcium sulfate, as well as residue of the absorbent. ...

UK PubMed Central (United Kingdom)

Vitamin D is now known to be of physiological importance outside of bone health and calcium homeostasis, and there is mounting evidence that it plays a beneficial role in the prevention and/or treatment...Full Text Available

UK PubMed Central (United Kingdom)

A filamentous fungus, Cunninghamella blakesleeana AS 3.153, was used as a microbial model of mammalian metabolism to transform verapamil, a calcium channel antagonist. The metabolites...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The spontaneous precipitation of calcium sulfate in supersaturated solutions over the temperature range between 25.0 and 80.0 C was investigated by monitoring the solution specific conductivity during desupersaturation. From measurements of the induction times preceding the onset of precipitation the surface energy of the forming solid, identified as gypsum, was found between ca. 12 and 25 mJ/m{sup 2} for the temperature range between 80.0 and 25.0 C, respectively. Kinetics analysis showed that over 50 C it is possible that anhydrous calcium sulfate is forming as a transient phase converting into the more stable calcium sulfate dihydrate. The linear dependence of the rates of precipitation on the relative solution supersaturation suggested a mechanism according to which the growth units are integrated into the active sites of the supercritical nuclei by surface diffusion. According to the morphological examination of the ...

UK PubMed Central (United Kingdom)

Direct radiological measurements of the mineral content of femoral bone were performed in 13 patients on maintenance dialysis. They were found to be sufficiently sensitive to be used for monitoring,...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

We have investigated the effect of manganese (Mn) doping on properties of nanosized biphasic calcium phosphate powders and their dense bodies. Manganese levels of 0.6, 1.3, 1.9, 4.3, 7.0 and 11.9at.% were successfully incorporated into biphasic calcium phosphate via a sol-gel route. The prepared powders were calcined at temperatures of 500-1200^oC. The X-ray diffraction analysis revealed that a mix phase comprising of hydroxyapatite and @b-tricalcium phosphate were present, however the content of each phases in the structure was affected by the Mn content. The studies found that the largest portion of @b-tricalcium phosphate was detected at 4.3at.% Mn doping. The incorporation of Mn has also greatly increased the crystallinity of the biphasic calcium phosphate powder due to progressive den...

International Nuclear Information System (INIS)

Main results of 15-year SSTC NRS activity in the field of technical support of regulatory authority are presented. The article also described management policy, quality assurance system, personnel training system and international co-operation of SSTC. (author)

UK PubMed Central (United Kingdom)

That regulatory T cells (Tregs) have a crucial role in controlling allergic diseases such as asthma is now undisputed. The cytokines most commonly implicated in Treg-mediated suppression of...Full Text Available

UK PubMed Central (United Kingdom)

Motivation: The identification of gene regulatory modules is an important yet challenging problem in computational biology. While many computational methods have been proposed to identify...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundA wide range of techniques is now available for analyzing regulatory networks. Nonetheless, most of these techniques fail to interpret large-scale transcriptional data...Full Text Available

Science.gov (United States)

The report analyzes the cost-effectiveness of two alternative regulatory options: A Treated Discharge Option and a Zero Discharge Option. The report compares the total annualized cost incurred for each of the two regulatory options to the corresponding ef...

Energy Technology Data Exchange (ETDEWEB)

An offshore drilling rig is described for use in drilling into a formation below a body of water comprising a barge hull having a drilling slot extending inwardly from the peripheral boundary of the barge hull, means for supporting the barge hull in a position above the water, a cantilever structure mounted on the barge hull and movable horizontally with respect to such barge hull, the cantilever structure being so located relative to the drilling slot as to be movable horizontally into a position in vertical alignment with the drilling slot, a derrick and drilling machinery mounted to the cantilever structure and movable into a position above the drilling slot whereby well drilling operations may be conducted through the drilling slot, the cantilever structure also being movable horizontally to a position which locates the derrick and the drilling machinery outboard of the peripheral boundary of the barge hull, whereby a drilling operations ...

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

International Nuclear Information System (INIS)

Oct 1976. 2 p. United States Nuclear Regulatory Commission, Washington,

Science.gov (United States)

... this critical information, we analyzed 17 years of timber harvest data gathered for regulatory purposes for a ... ...

Energy Technology Data Exchange (ETDEWEB)

This conference provided a forum to discuss advances in the application of bioengineering principles and practices dealing with biological systems for the production of food, bioproducts and energy. The topics of discussion ranged from engineering practices in agriculture, forestry, bioresources, biochemistry and biosystems. The sessions of the conference were entitled: renewable energy; waste management; soil and water; machinery systems; building and storage systems; and bioproducts and food. The conference also featured a workshop on integrated biomass supply and logistics. In addition to 20 posters, the conference featured 67 presentations, of which 3 have been catalogued separately for inclusion in this database. refs., tabs., figs.

International Nuclear Information System (INIS)

In the construction work for the Unit No.5 Turbine Building at Hamaoka Nuclear Power Station, the collaboration work for the planning and the coordination of the building construction and the machinery installation was carried out utilizing three-dimensional computer aided design (3D CAD) information. It was the first time in Japan for a building constructor and a plant manufacturer to work together, exchanging 3D CAD data of the whole building and adjusting the construction schedule. It was made possible to confirm the correspondence concerning the planning of both companies from the primary stage of the project by the total process simulation and to adjust on-going work precisely by the partial process simulation.

UK PubMed Central (United Kingdom)

Loss-of-function mutations in the regulatory gene areA of Aspergillus nidulans prevent the utilization of a wide variety of nitrogen sources. The phenotypes of nit-2 mutants of Neurospora crassa suggest...Full Text Available

UK PubMed Central (United Kingdom)

Inhibition of large conductance calcium-activated potassium (BK_Ca) channels mediates, in part, oxygen sensing by carotid body type I cells. However, BK_Ca channels remain active...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Earlier studies have indicated that xylitol may increase the absorption and urinary excretion of dietary oxalate. It has also been indicated that xylitol increases the absorption of calcium. Intestinal absorption of lead, a divalent contaminant in the diet, is in many respects similar to that of calcium. The purpose of this study was to evaluate the effects of xylitol on the intestinal absorption of lead using two different approaches: the in situ ligated intestinal loop technique in cockerels and gastric gavage in mice.

International Nuclear Information System (INIS)

Human complement protein C9 is shown to be a metalloprotein that binds 1 mol of Ca"2"+/mol of C9 with a dissociation constant of 3 #mu#m as measured by equilibrium dialysis. Incubation with EDTA removes the bound calcium, resulting in a apoprotein with decreased thermal stability. This loss in stability leads to aggregation and, therefore, to loss of hemolytic activity upon heating to a few degrees above the physiological temperature. Heat-induced aggregation of apoC9 can be prevented by salts that stabilize proteins according to the Hofmeister series of lyotropic ions, suggesting that the ion in native C9 may ligand with more than one structural element of domain of the protein. Ligand blotting indicates that the calcium binding site is located in the amino-terminal half of the protein. Removal of calcium by inclusion of EDTA in assay mixtures has no effect on the hemolytic activity of C9, and its capacity to bind to C8 in ...

Energy Technology Data Exchange (ETDEWEB)

In August 1995, the US Nuclear Regulatory Commission (NRC) issued a policy statement proposing improved regulatory decision making by increasing the use of probabilistic risk assessment (PRA) in all regulatory matters to the extent supported by the state-of-the-art in PRA methods and data. A key aspect in using PRA in risk-informed regulatory activities is establishing the appropriate scope and attributes of the PRA. In this regard, the American Society of Mechanical Engineers (ASME) decided to develop a consensus PRA standard. The objective is to develop a PRA standard such that the technical quality of nuclear plant PRAs will be sufficient to support risk-informed regulatory applications. The authors present example recommendations for the systems analysis element of a PRA for incorporation into the ASME PRA standard.

Energy Technology Data Exchange (ETDEWEB)

This report, the eighth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1992. A special emphasis on accomplishments in nuclear power plant aging research reflects recognition that a number of plants are entering the final portion of their original 40-year operating licenses and that, in addition to current aging effects, a focus on safety considerations for license renewal becomes timely. The primary purpose of performing regulatory research is to develop and provide the Commission and its staff with the technical bases for regulatory decisions on the safe operation of licensed nuclear reactors and facilities, to find unknown or unexpected safety problems, and to develop data and related information for the purpose of revising the ...

International Nuclear Information System (INIS)

The mechanism of lead transport is presented, and especially the particular similarities or dissimilarities between lead and calcium in this process. The absorption of these metals was determined cockerels, raised on a commercial diet or on a specified diet, using in vivo ligated loop procedure. The dose administered into the loop contained 0.5 #mu#Ci "2"0"3Pb (and/or 0.1 #mu#Ci "4"7Ca), and 0.01 mM lead acetate (and/or mM CaCl_2) in 0.5 ml 0.15 M NaCl,pH 6.5. It was shown that lead is rapidly taken up by the mucosal tissue, and slowly transferred into the body, whereas less calcium is retained by the tissue and the transfer of calcium is many times as effective as that for lead. They appear to respond in a similar manner to a low calcium intake and vitamin D treatment. Increasing luminal stable lead concentration significantly reduced the percentage of radiolead significantly reduced the percentage of ...

British Library Electronic Table of Contents (United Kingdom)

Endogenous opioid peptides (EOP) are molecules affecting many biological functions influencing productive and reproductive performance. They increase in stress conditions and interact with specific opioidergic receptors (OR): delta, kappa and mu. Several studies in other animal species suggest that they can also affect sperm cell motility. In fish the ionic external environment modulates the increase of intracellular calcium ion that is required to activate sperm motility after spawning. In mammals OR are functionally associated to calcium channels and in fishes calcium is highly required for fish sperm activation. In this study the presence of OR on spermatozoa of two Perciform fish, the sharpsnout seabream (Diplodus puntazzo, family Sparidae) and the European sea bass (Dicentrarchus labr...

Energy Technology Data Exchange (ETDEWEB)

This is a process for producing calcium sulfate dihydrate during desulfurization of stack gases from power station boilers, where the stack gases are introduced into a washing tower and are treated with a washing water suspension containing lime in the washing tower, where oxygen in the form of air or of air enriched in oxygen is also blown into the washing tower, and where the washing water suspension drawn off from the washing tower is fed back to the washing tower at a temperature of 45 to 50/sup 0/C in the circuit and at least part of the flow goes via a thickener and where calcium sulfate dihydrate slurry is drawn off from the thickener.

British Library Electronic Table of Contents (United Kingdom)

Mineral carbonation is based on the reaction of carbon dioxide with metal-oxide bearing minerals, usually containing magnesium or calcium silicate, to form hardly soluble carbonates and other solid byproducts. The concept is based on acceleration of the naturally occurring rock weathering process. In the present work the calcium silicate is present in the mineral, wollastonite. To accelerate the process and make it potentially useful for practical applications, mineral carbonation is conducted here using an indirect two-step route in which the reactive component (Ca^2^+ ions in considered case) is first extracted from the mineral matrix and afterwards carbonated. Two solid byproducts are formed in this process: silica in the extraction step and calcium carbonate in the carbonation step. In...

Energy Technology Data Exchange (ETDEWEB)

To examine the hormonal regulation of the ATP-dependent Ca{sup 2+} pump in the kidneys, the ATP-dependent Ca{sup 2+} uptake by the basolateral membrane vesicles in the renal cortex was measured using radioactive calcium ({sup 45}Ca{sup 2+}) in rats with vitamin D deficiency or rats undergoing thyroparathyroidectomy. The V{sub max} of the Ca{sup 2+} pump activity was increased not only by administering calcitriol, but also by normalizing the serum calcium level in vitamin D-deficient rats. PTH suppressed the Ca{sup 2+} pump activity in normocalcemic vitamin D-deficient rats. Thyroparathyroidectomy did not affect the Ca{sup 2+} pump activity in the kidneys of normal rats. It was concluded that the ATP-dependent Ca{sup 2+} pump activity was depressed by secondary hyperparathyroidism in vitamin D-deficient rats. (author).

International Nuclear Information System (INIS)

This paper describes stable strontium as composed of four stable isotopes ( Sr 88, Sr 87, Sr 86, and Sr 84), of which Sr 88 contributes more than 82% to its composition. Strontium exists in three crystalline, plymorphic forms; face-centered cubic alpha form, hexagonal beta form and body-centered cubic gamma form. Strontium occupies in many physicochemical aspects an intermediate position between calcium and barium, as does the solubility of strontium salts. As a result of its oxidation potential, strontium readily forms oxides, halides, and sulfide. The author proposes that the slight discrimination against strontium incorporation into bony tissues may be due to the difference in ionic potential (14%) between strontium and calcium. Ionic potential is an indicator of the strength of ionic bonds: strontium has a smaller ratio of ionic charge to ionic radius when compared with calcium.

Energy Technology Data Exchange (ETDEWEB)

This report, the seventh in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1991. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

Energy Technology Data Exchange (ETDEWEB)

This report, the sixth in a series of annual reports, was prepared in response to congressional inquiries concerning how nuclear regulatory research is used. It summarizes the accomplishments of the Office of Nuclear Regulatory Research during FY 1990. The goal of this office is to ensure that safety-related research provides the technical bases for rulemaking and for related decisions in support of NRC licensing and inspection activities. This research is necessary to make certain that the regulations that are imposed on licensees provide an adequate margin of safety so as to protect the health and safety of the public. This report describes both the direct contributions to scientific and technical knowledge with regard to nuclear safety and their regulatory applications.

Energy Technology Data Exchange (ETDEWEB)

This report is the second in a series of annual reports responding to congressional inquiries as to the utilization of nuclear regulatory research. NUREG-1175, ''NRC Safety Research in Support of Regulation,'' published in May 1986, reported major research accomplishments between about FY 1980 and FY 1985. This report narrates the accomplishments of FY 1986 and does not restate earlier accomplishments. Earlier research results are mentioned in the context of current results in the interest of continuity. Both the direct contributions to scientific and technical knowledge and their regulatory applications, when there has been a definite regulatory outcome during FY 1986, have been described.

UK PubMed Central (United Kingdom)

BackgroundChanges in ionic concentration have a fundamental effect on numerous physiological processes. For example, IP₃-gated thapsigargin sensitive intracellular calcium...Full Text Available

UK PubMed Central (United Kingdom)

SUMMARYIn voltage-gated sodium, potassium, and calcium channels the functions of ion conduction and voltage sensing are performed by two distinct structural units: the pore domain...Full Text Available

UK PubMed Central (United Kingdom)

Dominant mutations in sarcomere protein genes cause hypertrophic cardiomyopathy, an inherited human disorder with increased ventricular wall thickness, myocyte hypertrophy, and disarray. To understand...Full Text Available

UK PubMed Central (United Kingdom)

Secondary caries and restoration fracture remain the two most common problems in restorative dentistry. Release of fluoride ions (F) could be a substantial benefit because F could enrich neighboring...Full Text Available

UK PubMed Central (United Kingdom)

The transport of serine into tobacco (Nicotiana tabacum L. var. Xanthi) cells grown in liquid medium was studied. Serine transport was maximal below pH 4.0. A time-dependent stimulation...Full Text Available

UK PubMed Central (United Kingdom)

The H⁺-translocating inorganic pyrophosphatase (H⁺-PPase) associated with vesicles of the vacuolar membrane (tonoplast) isolated from beet (Beta vulgaris L.) is...Full Text Available

UK PubMed Central (United Kingdom)

Feedback controls of estrogen in LHRH-1 neurons play a pivotal role in reproductive function. However, the mechanism of estrogen action in LHRH-1 neurons is still unclear. In the present study, the...Full Text Available

International Nuclear Information System (INIS)

Radionuclide X-ray fluorescence analysis was used for the determination of iron, calcium, potassium, copper, manganese and zinc in waste water from the production process of citric acid. (author).

Energy Technology Data Exchange (ETDEWEB)

A process is given for the removal of sulfur oxides from exhaust gases by absorbing with a slurry of red mud containing calcium ion which comprises the steps of: (1) contacting an exhaust gas containing sulfur oxides of not higher than about 100/sup 0/ C with a slurry of red mud containing calcium ion led from the next step (2) to take up sulfur oxides in the gas until ph of the slurry becomes in the range of 4.3 to less than 6 while maintaining the molar fraction of SO/sub 4/-- to total SO/sub 2/ in the slurry within the said pH range at 0.05 to 0.7; and then, (2) contacting the treated gas with a fresh slurry of red mud containing calcium ion to further take up sulfur oxides in the gas while maintaining the concentration of NaHSO/sub 3/ in the slurry at not more than about 8 g/l.

UK PubMed Central (United Kingdom)

Some laboratory experiments have suggested that power-frequency electric and magnetic fields (EMF) may be capable of influencing calcium efflux from cell membranes, pineal function, and circadian rhythms....Full Text Available

UK PubMed Central (United Kingdom)

Epifluorescence images of Ca2+ transients elicited by electrical stimulation of single skeletal muscle fibers were studied with fast imaging techniques that take advantage of the large fluorescence...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Taiheiyo coal deashed using acid treatment and loaded with potassium or calcium was hydro-cracked under gaseous phase to discuss effects of these metals on liquefaction reaction. In addition, the loaded coal was added with red mud catalyst to examine effects of the addition. The loaded potassium has a softening power, and particularly the potassium adsorbed into surface and micropores in the coal decomposes selectively HI-BS and BI-PS and generates gas and HS. On the other hand, potassium deposited on coal surface promotes direct gas production from the coal. Irrespective of its loading modes, calcium has a catalytic nature to produce HI-BS selectively. Calcium also acts to impede decomposition of HI-BS into HS. Adding red mud catalyst to potassium loaded coal increases the inversion rate and the liquefaction yield, and most of the increase is accounted for by HI -BS, and BI-PS. When red mud catalyst is added to ...

UK PubMed Central (United Kingdom)

The amount of phosphorus contained in food as food additives is currently increasing and a high intake of phosphorus can cause various diseases. To determine the effects of a prolonged high phosphorus...Full Text Available

UK PubMed Central (United Kingdom)

Human Factor VIII/von Willebrand factor, purified by calcium citrate-cellulose chromatography and 4% agarose gel filtration was subjected to sodium dodecyl sulfate gel electrophoresis on gels containing...Full Text Available

UK PubMed Central (United Kingdom)

Plants respond to a large variety of environmental signals, including changes in the gravity vector (gravistimulation). In Arabidopsis (Arabidopsis thaliana) seedlings, gravistimulation...Full Text Available

International Nuclear Information System (INIS)

Laboratory testing at Combustion Engineering has indicated promise in controlling simulated steam generator tube denting through chemical neutralization. Testing was limited to on-line treatment, and two neutralizers have been evaluated: calcium hydroxide and boric acid. On-line treatment with calcium hydroxide successfully halted active denting whenever the bulk calcium concentration (in ppm) equaled or exceeded the bulk chloride concentration (in ppm). Calcium hydroxide also was effective as an alternative to ammonia as a pH controlling agent in two tests conducted without ingress of chloride. On-line treatment with boric acid consisted of a four-day soak at simulated low (approximately 30 percent) power with 50 ppm B followed by one month full-power operation with 10 ppm B. This treatment also halted denting. Nondestructive and destructive examination of test boilers gave no indication of adverse ...

UK PubMed Central (United Kingdom)

Benzodiazepine withdrawal anxiety is associated with potentiation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) currents in hippocampal CA1 pyramidal...Full Text Available

UK PubMed Central (United Kingdom)

Stomatal movements depend on both ion influx and efflux; attainment of steady state apertures reflects modulation of either or both processes. The role of Ca²⁺ in those two processes was...Full Text Available

UK PubMed Central (United Kingdom)

Amyloid proteins constitute a chemically heterogeneous group of proteins, which share some biophysical and biological characteristics, the principal of which are the high propensity to acquire an incorrect...Full Text Available

International Science & Technology Center (ISTC)

Realization of Pharmacological Tests, Development of the Specifications and Technical Documentation and Registration in the Russian Federation of Medical Products as Soluble Tablets of Acetylsalicylic Acid/Calcium Carbonate in Two Dosages Intended for use as Medical Products Smoothing, Febrifugal and Antiaggregation Action and Development of Technology of Tableting the Above-Stated Preparations

DEFF Research Database (Denmark)

The aim of the present study was to test a mathematical model of the biochemical processes in the parathyroid glands responsible for the secretion of parathyroid hormone resulting from extracellular calcium reduction. A double exponential curve described the parathyroid hormone secretion induced by rapid lowering of blood-ionized calcium in humans with normal as well as abnormal parathyroid tissue. Our data show that it was possible to establish a simple mathematical model of the parathyroid hormone response to blood-ionized calcium lowering, sufficient to fit experimental data obtained from patients with abnormal and normal parathyroid tissue. The fitted parameters showed no significant differences between patients with insulin-dependent diabetes mellitus and controls. In primary hyperparathyroidism, the parathyroid hormone production and steady-state transport across the cell membrane were increased, probably due to the ...

Science.gov (United States)

isotherme, dans un courant d'azote ou sous vide entretenu. I t. Comptes Rendus Scientific Academy, Paris, Vol. 265 pyrolyse du carbonate de calcium, ...

International Nuclear Information System (INIS)

Jun 1973. 2 p. United States USAEC Directorate of Regulatory Standards,

International Nuclear Information System (INIS)

In the aftermath of the 9/11 terrorist attacks on the United States, there was heightened interest worldwide in protecting nuclear power plants against intentional aircraft attack by terrorists. This paper presents our perspective into regulatory requirements for intentional aircraft crash that were set forth in foreign countries, including the latest rulemaking by the U.S. Nuclear Regulatory Commission (NRC), i.e., 10 CFR 50.54(hh) and 10 CFR 50.150 that have been made effective in May and July of 2009, respectively. In light of these international efforts to further enhance safety of NPPs, a study is also underway at the Korea Institute of Nuclear Safety (KINS) to establish an effective and efficient regulatory approach in consideration of the state of the art in this area

Science.gov (United States)

The parathyroid endocrine glands, usually four in number and about the size of a split pea, lie on either side of the posterior aspect of the thyroid gland. Occasionally one or more of these structures are found in an aberrant position in the neck or even in the superior mediastinum. The parathyroid secretion, parathormone, regulates the level of serum calcium within sharply defined limits. Lack of parathormone, with lowering of the serum calcium, results in hyper-irritability of skeletal muscle, the clinical condition known as tetany. This is encountered following inadvertent removal or bruising of the parathyroid glands at thyroidectomy. PMID:21488463

Energy Technology Data Exchange (ETDEWEB)

Air pollution constraints continue to intensify, resulting in solid waste volume increases. An example of this is coal burning power plant flue gas desulfurization by scrubbing. The aqueous suspensions of calcium sulfate hemihydrate or calcium sulfate dihydrate will exceed 200 million tons annually by the year 2000. Disposal of these wastes can have massive environmental effects, due to physical instability and leaching to groundwater. One alternate disposal technique is sulfopozzolanic fixation, converting the FGD waste by addition of fine coal ash and an alkaline earth additive, into a monolithic mass. 6 refs., 17 figs., 3 tabs.

Energy Technology Data Exchange (ETDEWEB)

Calcium sulfate dihydrate in large crystal form is produced by maintaining the circulation of the lime containing scrubbing solution in the desulfurization scrubbing of flue gases from a power plant boiler so that it has a residence time of 5 to 25 hours, preferably 15 hours. The crystals are moved by passing a portion of the recirculation through a thinner in which a sludge containing crystals with a mean particle size of which 90% is in excess of 100 microns is removed. This product can be dewatered and treated with sulfuric acid and steam to convert it to the alpha semihydrate and is free from sulfite.

Energy Technology Data Exchange (ETDEWEB)

A heat storage compostion comprises sodium sulfate decahydrate as main component, a supercooling inhibitor, and a solid-liquid separation inhibitor. The composition is characterized in that hydraulic calcium sulfate and/or calcium sulfate dihydrate is contained as the solid-liquid separation inhibitor in an amount of 2-15 wt% base on the whole weight of the composition, whereby the solid-liquid separation, i.e. the sedimentation of the anhydrous sodium sulfate during the phase transition, is effectively prevented and the long-term stability is improved. The long-term stabilty of the composition can be more improved by addition of a silcia series of thickener.

British Library Electronic Table of Contents (United Kingdom)

The recent advances in RFID offer vast opportunities for research, development and innovation in agriculture. The aim of this paper is to give readers a comprehensive view of current applications and new possibilities, but also explain the limitations and challenges of this technology. RFID has been used for years in animal identification and tracking, being a common practice in many farms. Also it has been used in the food chain for traceability control. The implementation of sensors in tags, make possible to monitor the cold chain of perishable food products and the development of new applications in fields like environmental monitoring, irrigation, specialty crops and farm machinery. However, it is not all advantages. There are also challenges and limitations that should be faced in the...

Energy Technology Data Exchange (ETDEWEB)

Wheeling electric power, the transmission of electricity not owned by an electric utility over its transmission lines, is a term not generally recognized outside the electric utility industry. Investigation of the term`s origin is intriguing. For centuries, wheel has been used to describe an entire machine, not just individual wheels within a machine. Thus we have waterwheel, spinning wheel, potter`s wheel and, for an automobile, wheels. Wheel as a verb connotes transmission or modification of forces and motion in machinery. With the advent of an understanding of electricity, use of the word wheel was extended to be transmission of electric power as well as mechanical power. Today, use of the term wheeling electric power is restricted to utility transmission of power that it doesn`t own. Cogeneration refers to simultaneous production of electric and thermal power from an energy source. This is more efficient than separate production of electricity and thermal power ...

British Library Electronic Table of Contents (United Kingdom)

Zeaxanthin is a carotenoid produced by plants and has been associated with protection of the photosynthetic machinery under light stress and, together with lutein, in protection of the central retina of the eye. Zeaxanthin levels in blood plasma have been negatively correlated to the development of AMD (age-related macular degeneration) (Gale et al., 2003). Under normal conditions, plants have a low content of zeaxanthin. The aim of this study was to increase the zeaxanthin content in green vegetables by post harvest treatments. Efficient conditions for activation of the endogenous enzyme system generating zeaxanthin was established and included incubation at low pH (2.5-5.5), with the membrane permeable acetic acid/acetate buffer at room temperature or above for 30min or more. Typically m...

International Nuclear Information System (INIS)

The dynamic response of cylindrical and ring-shaped YBaCuO bulk parts to pulsed magnetic fields is calculated by using small sets of finite elements. Some comparisons with experimental results are provided, and they give confidence in the modelling of the superconducting properties. Transient magnetizations as a function of time and space as well as shapes and absolute values of trapped magnetic flux profiles are presented. The influence of the sample geometry is investigated for different millisecond pulsed magnetization processes. Results are reported for different radial thicknesses and heights, different pulse durations, peak magnetic fields and pulse sequences with and without stepwise cooling. Comparisons concerning the achievable trapped magnetic field and flux are made, and implications for the use of high-temperature superconductor bulk parts as cryo-permanent magnets in potential applications like electric machinery are discussed.

Energy Technology Data Exchange (ETDEWEB)

In order to suppress resonance vibrations of a rotor-shaft of rotating machinery, a rotor-shaft system elastically supported by ball bearings which are installed in electromagnetic actuators are proposed and the design method of some compensatory circuits in the controller to control the electromagnetic actuators in the system are explained. These actuators are controlled by the analog PID (proportional, integral, and derivative) controller. The compensation for nonlinearity of electromagnetic force, the negative stiffness of electromagnet, and the time lag of the coil current are discussed and the effective control circuits are proposed. The rotor-shaft system is replaced by the equivalent two-degree-of-freedom system and both impulse and frequency responses are numerically simulated for several parameters of PD-controller gain. By applying the principle of dynamic absorbers, optimum parameters are calculated. The gains of the control circuit are adjusted to give ...

UK PubMed Central (United Kingdom)

In the early 1970s a spate of papers by research groups around the world provided evidence for a negative regulatory role of thymus-derived lymphocytes (T cells). In 1971, Gershon and Kondo published...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Public Law 95-209 includes a requirement that the Advisory Committee on Reactor Safeguards submit an annual report to Congress on the safety research program of the Nuclear Regulatory Commission. This report presents the results of the ACRS review and evaluation of the NRC safety research program for Fiscal Year 1983. The report contains a number of comments and recommendations.

Energy Technology Data Exchange (ETDEWEB)

This report presents information and analysis to assist BLM in clarifying oil shale research needs. It provides technical guidance on research needs in support of their regulatory responsibilities for onshore mineral activities involving oil shale. It provides an assessment of research needed to support the regulatory and managerial role of the BLM as well as others involved in the development of oil shale resources on public and Indian lands in the western United States.

Energy Technology Data Exchange (ETDEWEB)

This document contains eleven papers on various aspects of low-level radioactive waste regulation. Topics include: EPA environmental standards; international exemption principles; the concept of below regulatory concern; envirocare activities in Utah; mixed waste; FUSRAP and the Superfund; and a review of various incentive programs. Individual papers are processed separately for the data base. (TEM)

Energy Technology Data Exchange (ETDEWEB)

The study concludes that while the diversification into nonutility activities by the Rural Electric Cooperatives and the Rural Telephone Cooperatives has been expanding, the regulatory activities by the Rural Electrification Administration and the state public utility commissions have been inadequate to guard against cross-subsidization. In fact, there generally exist no data to identify and investigate illegal cross-subsidization activities of cooperatives. Increasing the regulatory functions of state public utility commissions and the REA was recommended.

UK PubMed Central (United Kingdom)

Background: Hypertriglyceridemia is a risk factor for cardiovascular disease. Variation in the apolipoprotein A5 (APOA5) and glucokinase regulatory protein (GCKR)...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The goal of this study is to estimate the relevance and Influence of the Existing Regulation and the RI-PBR to the institutionalization of the regulatory system. This study reviews the current regulatory system and the status of the RI-PBR implementation of the US NRC and Korea based upon SECY Papers, Risk Informed Regulation Implementation Plan (RIRIP) of the US NRC and other domestic studies. In order to investigate the perceptions, knowledge level, ground for the regulatory change, a survey was performed to Korean nuclear utilities, researchers and regulators on the perception on the RIR. The questionnaire was composed of 50 questions regarding personal details on work experience, level of education and specific field of work ; level of knowledge on the risk informed performance based regulation (RI-PBR); the perception of the current regulation, the effectiveness, level of procedure, flexibility, dependency on the ...

Energy Technology Data Exchange (ETDEWEB)

The present study was designed to investigate, in more detail, the mechanism of lead transport by the gastrointestinal tract and particularly the similarities or dissimilarities between lead and calcium in this process. The absorption of these metals was determined in 3-week-old white Leghorn cockerels, raised on a commercial diet or special diets, using an in vivo ligated loop procedure. The dose administered into the loop usually contained 0.5 ..mu..Ci /sup 203/Pb (and/or 0.1 ..mu..Ci /sup 47/Ca), 0.01 mM lead acetate (and/or 1 mM CaCl/sub 2/) in 0.5 ml of 0.15 M NaCl, pH 6.5. It was shown that lead is rapidly taken up by the intestinal tissue, and only slowly transferred into the circulation whereas calcium, also accumulated rapidly by the tissue, is rapidly released from the tissue in the serosal direction. The absorption processes of these cations show similar responses to various experimental conditions (low calcium ...

Energy Technology Data Exchange (ETDEWEB)

The kinetics of calcium sulfate crystal growth is of importance in various fields, such as geochemistry, desalination technology, petroleum industry, and water and wastewater treatment. The seeded crystal growth rate of calcium sulfate dihydrate was measured as a function of supersaturation in NaCl electrolyte solutions from 0 to 6 m at temperatures of 25, 50, 70, and 90 C. The growth followed a second-order parabolic rate law with activation energies greater than 53 kJ/mol which suggested the surface reaction as the rate-limiting step. It was observed that the rate constant and the activation energy are solution composition dependent. The rate constant increases with NaCl concentration up to 3 molal and then begins to fall slightly. The activation energy dropped from 61 kJ/mol in the pure Ca-SO[sub 4]H[sub 2]O system to 53 kJ/mol in 3.0 m NaCl solutions. The electrolyte effect was similar to the crystal solubility behavior in aqueous ...

Energy Technology Data Exchange (ETDEWEB)

The paper gives results of a study to identify active sites and surface functional groups that may contribute to the absorption of elemental mercury (Hg) by relatively inexpensive calcium (Ca)-based sorbents. The study investigated the formation of chlorine (Cl) sites in CA-based sorbents as well as their role and reactivity in the absorption of Hg. HCl-exposed calcium sulfate dihydrate (gypsum) exhibited a superior Hg sorption capability. Crystalline water molecules on the surface of the gypsum were confirmed to contribute indirectly to Hg uptake. These surface molecules may have absorbed HC1 through hydrogen bond formation between an oxygen atom of a crystalline water molecule and a hydrogen atom of an HCl molecule. Two adjacent, physically absorbed HCl molecules could then trap an Hg molecule through formation of a mercuric-chloride-like molecule. Significant correlations between Cl and Hg uptake by gypsum were noted.

International Nuclear Information System (INIS)

In vivo effects of toxaphene on calcium pump activity in rat brain synaptosomes was studied. Male Sprague-Dawley rats were dosed with toxaphene at 0,25,50, and 100 mg/kg/day for 3 days and sacrificed 24 h after last dose. Ca"2"+-ATPase activity and "4"5Ca uptake were determined in brain P_2 fraction. Toxaphene inhibited both Ca"2"+-ATPase activity and "4"5Ca"2"+ uptake and the inhibition was dose dependent. Both substrate and Ca"2"+ activation kinetics of Ca"2"+-ATPase indicated non-competitive type of inhibition as evidenced by decreased catalytic velocity but not enzyme-substrate affinity. The inhibited Ca"2"+-ATPase activity and Ca"2"+ uptake were restored to normal level by exogenously added calmodulin which increased both velocity and affinity. The inhibition of Ca"2"+-ATPase activity and Ca"2"+ uptake and restoration by calmodulin suggests that toxaphene may impair active calcium transport mechanisms by decreasing regulator protein ...

International Nuclear Information System (INIS)

Denting studies have been undertaken in order to assess the influence of the most important parameters which could initiate corrosion of the carbon-steel occurring in the tube-tube support plate crevices of some PWR steam generators. Tests have been carried out in model boilers, feedwater being polluted with sea or river water. Specific effect of chloride or sulfate and influence of oxygen content, magnetite addition and pH value were investigated. In magnetite prepacked crevices, denting is obtained within 1000 hours for sea-water pollution of 0.3 ppm chloride at the blowdown. In neutral chloride or in river water denting is observed only with oxygen addition. Denting prevention is effective in the case of an on-line addition of phosphate, boric acid or calcium hydroxide. For denting stopping, boric acid or calcium hydroxide is efficient even with a high sea-water pollution. Soaks cannot stop denting if they are not followed by an on-line ...

Energy Technology Data Exchange (ETDEWEB)

This project is part of PETC`s Advanced Power Systems Program, whose mission is to accelerate the commercialization of affordable, high- efficiency, low emission, coal-fueled electric generating technologies. A process concept - Clear Liquor Scrubbing with Anhydrite Production - was proposed and accepted by PETC as a Phase I project in its Mega-PRDA program. the project integrated three process operations - chloride control upstream of the flue gas desulfurization (FGD) system, a clear liquor process for enhanced SO{sub 2} removal performance, and production of anhydrite (anhydrous calcium sulfate) rather than calcium sulfite or gypsum (calcium sulfate dihydrate). The first step in the project was to perform batch and flow-through experiments in the laboratory to confirm theoretical calculations and preliminary laboratory results concerning anhydrite formation, these laboratory experiments were designed to prove that ...

Energy Technology Data Exchange (ETDEWEB)

A method and an instrument for determining the total water content in a hydrocarbon fuel using an indicator composition, which includes calcium hydride and phenolphthaleyn, are developed. The essence of the method is fixing the presence of water with its interaction with the calcium hydride and subsequent indication of the formed Ca(OH)2 using the phenolphthallen. To make the indicator composition, a hygroscopic cotton, prewashed by rectified alcohol and dried for 30 minutes at 105 degrees, is impregnated by a 1 percent alcohol solution of phenolphthaleyn and is dried in the same conditions. Then the cotton is processed by a powder form calcium hydride (a layer thickness of 0.1 to 0.2 millimeters, and a granule size of less than or equal to 80 micromters). The indicator composition is placed in a glass tube (a diameter of 4 to 7 millimeters and a length of 80 to 100 millimeters), whose ends are sealed or filled with ...

International Nuclear Information System (INIS)

Industrial radiography accounts for approximately half of all the reported accidents for the nuclear related industry, in both developed and developing countries. This Safety Report is the result of a review made of a large selection of accidents in industrial radiography reported by regulatory authorities, professional associations and scientific journals. A small, representative selection of 43 accident descriptions has been used to illustrate the primary causes of radiography accidents, and a set of measures provided to prevent the recurrence of such accidents or to mitigate the consequences of those that do occur. These accident descriptions were categorized by primary causes as follows: inadequate regulatory control; failure to follow operational procedures; inadequate training; inadequate maintenance; human error; equipment malfunction or defect; design flaws; and wilful violation. The information in this Safety report is intended for use ...

International Nuclear Information System (INIS)

A brief description is given of the physico-chemical parameters characterized a hot water geothermal reservoir and of its exploitation by means of single or coupled (doublet) wells. The technical aspects of geothermal heat to the users is then discussed, beginning with corrosion of materials caused by seven main agents: oxygen, hydrogen sulphide, carbon dioxide, ammonia, hydrogen, sulphates and chlorides. A brief mention is made of scaling due to calcium carbonate, silica and calcium sulphates. The basic components of a geothermal plant for non-electric uses are then discussed: production pumps, surface pipelines, heat exchangers, heat pumps and reinjection pumps. The advantages and disadvantages of the different equipment and materials used in the geothermal sector are also presented. A list is also given of the criteria used in the energy and economic balance of a geothermal operation. (author). 24 refs, 13 figs, 2 tabs.

British Library Electronic Table of Contents (United Kingdom)

ObjectiveTo study a method of chemical sterilization and its efficacy in adult male stray dogs.MethodsSterilization was performed 45 days after a single bilateral intratesticular injection of calcium chloride (CaCl2) at the doses of 5, 10, 15 or 20 mg per testis per kg body weight.ResultsHistomorphological measures of testes showed total necrosis of testicular tissue at 45 days after an injection of either 10 or 15 or 20 mg CaCl2 along with fibrosis and hyalinization in seminiferous tubules and interstitial spaces. Infiltration of leucocytes was also observed with the 10- or 15-mg dose. Disintegration of germ cell arrangement in seminiferous tubules and washing out of germ cells from the tubules were noted with the 5-mg dose. Relative organ weight, epididymal sperm count, plasma and intrat...

Environmental Research Database

ObjectivesTo determine the reaction rate of slag during curing and factors affecting reactivity.~%~~%~To measure the rates of chloride ingress into concrete and the extent of chloride binding.~%~~%~To determine conditions for pitting corrosion and the nature of corrosion products.~%~~%~To characterise the reactions in slag-calcium alumina cement hydration and the nature of the products.~%~DescriptionBlast-furnace slag has latent hydraulic properties, giving considerable potential for commercial use in addition to its widespread use as a partial replacement for Portland cement, notably in alkali-activated slag (AAS) and slag-calcium alumina cement (CAC) concretes. Use of AAS concretes is already well-established in China and the former USSR, but their further application is hindered by lack of research into setting, hydration and durability, Slag/CAC blends are new materials whose chemistr ...

British Library Electronic Table of Contents (United Kingdom)

BACKGROUND AND PURPOSE Controlling vascular tone involves K+ efflux through endothelial cell small- and intermediate-conductance calcium-activated potassium channels (KCa2.3 and KCa3.1, respectively). We investigated the expression of these channels in astrocytes and the possibility that, by a similar mechanism, they might contribute to neurovascular coupling. EXPERIMENTAL APPROACH Transgenic mice expressing enhanced green fluorescent protein (eGFP) in astrocytes were used to assess KCa2.3 and KCa3.1 expression by immunohistochemistry and RT-PCR. KCa currents in eGFP-positive astrocytes were determined in situ using whole-cell patch clamp electrophysiology. The contribution of KCa3.1 to neurovascular coupling was investigated in pharmacological experiments using electrical field stimulatio...

International Nuclear Information System (INIS)

A method is described for determination of aluminium, cadmium, cobalt, chromium, copper, calcium, magnesium, sodium, potassium, manganese, nickel, lead, strontium, zinc, titanium and vanadium in iron ore. After dissolution, a 1 gram sample of iron ore is applied to a column of AGI-X8 anion exchange resin (chloride form), in 100 ml of 7M HCl. Aluminium, chromium, calcium, magnesium, sodium, potassium, manganese, nickel, lead, strontium, titanium and vanadium are eluted with 7M HCl; iron, copper and cobalt are eluted with 0.5M HCl; cadmium and zinc are eluted with 2M HNO_3. Iron is subsequently removed from copper and cobalt by a solvent extraction with methyl isobutyl ketone. The elements are determined in the eluates by atomic absorption spectrometry, except for titanium and vanadium, which are determined spectrophotometrically.

Energy Technology Data Exchange (ETDEWEB)

The combined Lewis and Broensted acidities were measured of 13X (sodium) zeolite and of its 84.2% calcium-exchanged, 86.0% lanthanum-exchanged, and 69.2% protonated forms, calcined at 400/sup 0/C. The butylamine titrations were performed to visible color changes of Hammett indicators. The H/sub 0/ acidities were 0 for the sodium X zeolite, and 0.2, 0.98, and 0.75 for the calcium, lanthanum, and hydrogen zeolites, respectively. These acidities compared well with trends reported in literature for zeolites pretreated under different conditions. Titration of Broensted sites with arylmethanol indicators did not give satisfactory visible endpoints.

UK PubMed Central (United Kingdom)

Wiskott-Aldrich syndrome protein (WASp) is essential for optimal T cell activation. Patients with WAS exhibit both immunodeficiency and a marked susceptibility to systemic autoimmunity. We investigated...Full Text Available

UK PubMed Central (United Kingdom)

In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in...Full Text Available

UK PubMed Central (United Kingdom)

Memory consolidation requires transcription and translation of new protein. Arc, an effector immediate early gene, and zif268, a regulatory transcription factor, have been implicated in synaptic plasticity...Full Text Available

UK PubMed Central (United Kingdom)

The RNA-binding protein Hfq is recognized as an important regulatory factor in a variety of cellular processes, including stress resistance and pathogenesis. Hfq has been shown in several bacteria to...Full Text Available

UK PubMed Central (United Kingdom)

Background/AimsHelicobacter pylori (H. pylori) infection appears to subvert the human iron regulatory mechanism and thus upregulates hepcidin, resulting...Full Text Available

UK PubMed Central (United Kingdom)

A regulatory locus on the Staphylococcus aureus chromosome, designated sar, is involved in the expression of cell wall proteins, some of which are potentially important in the pathogenesis of endocarditis....Full Text Available

UK PubMed Central (United Kingdom)

The level of bone morphogenetic protein 2 (BMP2) profoundly influences essential cell behaviors such as proliferation, differentiation, apoptosis, and migration. The spatial and temporal pattern...Full Text Available

UK PubMed Central (United Kingdom)

Phospho-beta-galactosidase (P-beta-gal), the enzyme which catalyzes the first step in the metabolism of intracellular lactose phosphate, occurred at high specific activity in the cytoplasm in 12 of...Full Text Available

UK PubMed Central (United Kingdom)

Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans. We argue that it is always more useful to...Full Text Available

UK PubMed Central (United Kingdom)

Medical treatment of heroin addiction with methadone and other pharmacotherapies has important benefits for individuals and society. However, regulatory policies have separated this treatment from the...Full Text Available

UK PubMed Central (United Kingdom)

Government agencies responsible for protecting the public from the adverse effects of toxic chemicals must set priorities for research, regulatory action, protocol testing, and monitoring due to the...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

This report includes the issuances received during the specified period from the Commission, the Atomic Safety and Licensing Appeal Boards, the Atomic Safety and Licensing Boards, the Administrative Law Judge, the Directors' Decisions, and the Denials of Petitions for Rulemaking.

Energy Technology Data Exchange (ETDEWEB)

This report includes the issuances received during the specified period from the Commission (CLl), the Atomic Safety and Licensing Appeal Boards (ALAB), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judge (ALJ), The Directors' Decisions (DD), and the Denials of Petitions For Rulemaking (DPRM).

Energy Technology Data Exchange (ETDEWEB)

The Regulatory Agenda is a semiannual compilation of all rules on which the NRC has recently completed action, or has proposed action, or is considering action, and of all petitions for rulemaking that the NRC has received that are pending disposition.

UK PubMed Central (United Kingdom)

Choline (Cho)-containing phospholipids are the most abundant phospholipids in cellular membranes and play fundamental structural as well as regulatory roles in cell metabolism and signaling. Although...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Electricity markets in the United States are undergoing unprecedented structural changes as a result of the confluence of regulatory, competitive, and technological forces. This paper introduces these structural changes and forces and discuss the implications, markets and commercialization scenarios for emerging fuel cells in evolving US electricity markets.

Science.gov (United States)

This manual provides information to assist in selection and designing control measures for reducing pollutant discharges from combined sewer overflows (CSOs). he manual will be useful for municipal public works staff, design engineers, and regulatory agency staff tasked with the ...

UK PubMed Central (United Kingdom)

BackgroundModern approaches to treating genetic disorders, cancers and even epidemics rely on a detailed understanding of the underlying gene signaling network. Previous work has...Full Text Available

UK PubMed Central (United Kingdom)

Myosin phosphatase target subunit 1 (MYPT1) is the regulatory subunit of myosin light chain phosphatase (MLCP). It plays a critical role in vasodilatation induced by cGMP-elevating agents such as nitric...Full Text Available

UK PubMed Central (United Kingdom)

Skeletal formation is an essential and intricately regulated part of vertebrate development. Humans and mice deficient in Growth and Differentiation Factor 6 (Gdf6) have numerous...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Progress is reported in the following subject areas: (1) chemistry of the arogenate molecule; (2) plant enzymology at the organismal level; (3) isolation of regulatory mutants in tobacco; and (4) stability of the haploid state in Nicotiana sylvestris.

UK PubMed Central (United Kingdom)

The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity. Recently,...Full Text Available

UK PubMed Central (United Kingdom)

FXYD1 (phospholemman) is a member of an evolutionarily conserved family of membrane proteins that regulate the function of the Na,K-ATPase enzyme complex in specific tissues and specific physiological...Full Text Available

Science.gov (United States)

The report presents detailed technical information concerning application of flue gas desulfurization (FGD) systems to industrial boilers. The information was obtained by a survey of plant personnel, control system vendors, regulatory agencies, and consulting engineering firms. T...

Science.gov (United States)

This analysis, submitted in support of proposed effluent limitations guidelines and standards for the centralized waste treatment (CWT) industry, investigates the cost-effectiveness of 24 regulatory options, representing all possible combinations of nine ...

UK PubMed Central (United Kingdom)

Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations,...Full Text Available

UK PubMed Central (United Kingdom)

Zipper-interacting protein kinase (ZIPK) is a member of the death-associated protein kinase family associated with apoptosis in nonmuscle cells where it phosphorylates myosin regulatory light chain...Full Text Available

UK PubMed Central (United Kingdom)

Biosynthesis and uptake of siderophores in Aspergillus nidulans are regulated not only by iron availability but also by ambient pH: expression of this high-affinity iron uptake system...Full Text Available

UK PubMed Central (United Kingdom)

Oncolytic viruses (OVs) represent a relatively novel anti-cancer modality. Like other new cancer treatments, effective OV therapy will likely require combination with conventional treatments. In order...Full Text Available

UK PubMed Central (United Kingdom)

The accumulation of α-1,4-polyglucans is an important strategy to cope with transient starvation conditions in the environment. In bacteria and plants, the synthesis of glycogen and starch occurs...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSearching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge for...Full Text Available

UK PubMed Central (United Kingdom)

KLF1 regulates a diverse suite of genes to direct erythroid cell differentiation from bipotent progenitors. To determine the local cis-regulatory contexts and transcription factor networks...Full Text Available

UK PubMed Central (United Kingdom)

Leaf senescence is a developmentally programmed degeneration process, which is fine tuned by a complex regulatory network for plant fitness. However, molecular regulation of leaf senescence is poorly...Full Text Available

International Nuclear Information System (INIS)

It needs accurate estimation of radiation level for verifying machinery and cable in Nuclear Power Plant. Therefore, in this study, we used ESR(Electron Spin Resonance) system for estimate dose of Alanine dosimeter. Alanine/ESR dosimetry, already known as a dosimetric method in medical and industrial field, was applied to estimate dose quantity at cable locations within a nuclear power plant as a part of equipment qualification program. Alanine/ESR dosimetry of absorbed dose range is 1 - 100 KGy. The alanine dosimeter is not significantly affected by temperature and fading is limited to 1% per year. The alanine dosimeters were fixed on the targeted cable or nearest position to measure dose quantity to get accurate value. Alanine dosimeters were scanned by commercially used two different ESR systems, e-scan and EMX series for alanine dosimeters. To estimate more accurate dose, two environmental correction factors, irradiation temperature and dosimeter weight, were ...

Energy Technology Data Exchange (ETDEWEB)

Sandia National Laboratories has recently developed two major field test capabilities for unattended ground sensor systems at the Department of energy`s Nevada Test Site (NTS). The first capability utilizes the NTS large area, varied terrain, and intrasite communications systems for testing sensors for detecting and tracking vehicular traffic. Sensor and ground truth data can be collected at either of two secure control centers. This system also includes an automated ground truth capability that consists of differential Global Positioning Satellite (GPS) receivers on test vehicles and live TV coverage of critical road sections. Finally there is a high-speed, secure computer network link between the control centers and the Air Force`s Theater Air Command and Control Simulation Facility in Albuquerque NM. The second capability is Bunker 2-300. It is a facility for evaluating advanced sensor systems for monitoring activities in underground cut-and-cover facilities. The main part of the ...

Energy Technology Data Exchange (ETDEWEB)

Squeeze film dampers (SFD) are devices utilized to control vibrations of the shafts of high-speed rotating machinery. The SFD - squirrel cage combination is probably the most used system for tuning the stiffness and damping of the supports for rotors installed on ball bearings. Squeeze film dampers are essentially hydrodynamic bearings which contain the ball bearings housings of ball-bearings supported shafts. Consequently, the oil film within the SFD are influenced only by the precession and nutation of the shaft, that is the flow of the oil within the damper is not directly influenced by the spin of the rotor. However, in the classical theory, the flow in the thin film is also governed by the Reynolds equation. In this paper, some of the limits of the classical theory of the SFD are discussed and theoretical and experimental studies, which illustrate the ideas presented herein, are presented as well. The orbits of an unbalanced rotor that is supported by a ...

Energy Technology Data Exchange (ETDEWEB)

The power source facilities of JT-60 consist of poloidal magnetic coil power source, toroidal magnetic coil power source, the power generation facility for heating, operation power distribution facility and secondary cooling facility, and at the time of the experiment operation of JT-60, they supply 1300 MVA of instantaneous maximum power to loads. The component machinery and equipment of the power source facilities are installed in about 20 indoor and outdoor places, and their mounted parts are about 15,000 kinds. About 3,000 kinds of spare parts are preserved in 15 exclusively used stores. The managing system for mounted parts and spare parts of JT-60 power source facilities which possesses the functions of rapidly and efficiently carrying out the storage of large quantity of information, mutual relating and retrieval by making mounted parts and spare parts into a data base and doing their unified management with a computer was constructed. As for the software, ...

Energy Technology Data Exchange (ETDEWEB)

Ventilation, cooling and illumination of modern high-rise office buildings with high-quality thermal insulation (average k-value 1.0 W/m12K) and high loads from office machinery (up to 20 W/m12 and beyond) are problematic even for modern facility management systems, with consequences for the building shell, heating system, and window ventilation. [Deutsch] Die Lueftung, Kuehlung und Beleuchtung moderner Buerohochbauten mit extremer Waermedaemmung (mittlerer K-Wert 1,0 W/m{sup 2}K) und hohen Bueromaschinenlasten (bis zu 20 W/m{sup 2} und mehr) verursachen auch heute noch erhebliche Probleme, obwohl die technische Gebaeudeausruestung weiterentwickelt wurde. Dies zeigt sich vor allem bei der Fassadenausbildung der Heizung und Fensterlueftung. (orig.)

Energy Technology Data Exchange (ETDEWEB)

The subject of FDD (fault detection and diagnosis) has gained widespread industrial interest in machine condition monitoring applications. This is mainly due to the potential advantage to be achieved from reduced maintenance costs, improved productivity and increased machine availability. This paper presents a new FDD scheme for condition machinery of an industrial steam turbine using a data fusion methodology. Fusion of a SVM (support vector machine) classifier with an ANFIS (adaptive neuro-fuzzy inference system) classifier, integrated into a common framework, is utilized to enhance the fault detection and diagnostic tasks. For this purpose, a multi-attribute data is fused into aggregated values of a single attribute by OWA (ordered weighted averaging) operators. The simulation studies indicate that the resulting fusion-based scheme outperforms the individual SVM and ANFIS systems to detect and diagnose incipient steam turbine faults. (author)

Science.gov (United States)

Group B Streptococcus (GBS) is the leading cause of meningitis in newborn infants. Bacterial cell surface appendages, known as pili, have been recently described in streptococcal pathogens, including GBS. The pilus tip adhesin, PilA, contributes to GBS adherence to blood-brain barrier (BBB) endothelium; however, the host receptor and the contribution of PilA in central nervous system (CNS) disease pathogenesis are unknown. Here we show that PilA binds collagen, which promotes GBS interaction with the ?(2)?(1) integrin resulting in activation of host chemokine expression and neutrophil recruitment during infection. Mice infected with the PilA-deficient mutant exhibit delayed mortality, a decrease in neutrophil infiltration and bacterial CNS dissemination. We find that PilA-mediated virulence is dependent on neutrophil influx as neutrophil depletion results in a decrease in BBB permeability and GBS-BBB penetration. Our results suggest that the bacterial pilus, specifically the PilA ...

International Nuclear Information System (INIS)

This document defines the services the Waste Sampling and Characterization Facility (WSCF) shall provide Effluent Monitoring (EM) throughout the calendar year for analysis. The internal memo contained in Appendix A identifies the samples Em plans to submit for analysis in CY-1995. Analysis of effluent (liquid and air discharges) and environmental (air, liquid, animal, and vegetative) samples is required using standard laboratory procedures, in accordance with regulatory and control requirements. This report describes regulatory reporting requirements and WSCF services and data quality objectives.

Energy Technology Data Exchange (ETDEWEB)

Abstract: The Hanford Tanks Initiative (HTI) is a five-year project resulting from the technical and financial partnership of the U.S. Department of Energy`s Office of Waste Management (EM-30) and Office of Science and Technology Development (EM-50). The HTI project accelerates activities to gain key technical, cost performance, and regulatory information on two high-level waste tanks. The HTI will provide a basis for design and regulatory decisions affecting the remainder of the Tank Waste Remediation System`s tank waste retrieval Program.

International Nuclear Information System (INIS)

Different cases exist in various countries regarding the institutional status, the organization and the technical resources of the Nuclear Regulatory Authority (NRA): there are NRAs having extended internal technical capability and others relying mostly on external technical support. Considering the research and development activities and the very broad range of technical matters on which the regulatory and licensing activity are based, the NRA can not rely only on internal resources, and generally there is the need of technical and scientific support together with enhanced international cooperation. The international cooperation and networking among NRAs, and their Technical Support Organizations (TSO), represents a fundamental way to maintain competence, capability and knowledge. Within the EU member states this is becoming more and more an institutional duty. In providing technical support for regulatory activity, the ...

International Nuclear Information System (INIS)

The separation, concentration, and determination of trace elements in iron ores are described. After the sample has been dissolved, the iron is separated by liquid-liquid extraction with a liquid cation-exchanger, di-(2-ethylhexyl) phosphoric acid. The trace elements aluminium, cadmium, calcium, chromium, cobalt, copper, lead, magnesium, manganese, mercury, potassium, sodium, vanadium, and zinc are determined in the aqueous phase by atomic-absorption spectrophotometry.

Science.gov (United States)

The aim of the current investigation was to study the effects of sevelamer hydrochloride (RenaGel) on serum phosphate, intact parathyroid hormone levels (iPTH), and lipid profiles in stable hemodialysis patients. Hemodialysis patients maintained on calcium containing phosphate binders were enrolled in this study. Following two weeks of washout of the phosphate binders, serum phosphate rose from 6.4 +/- 0.6 to 10.5 +/- 0.7 mg/dl (p <0.001). After 8 weeks of titration with sevelamer hydrochloride, serum phosphate fell by 4.5 +/- 0.3 to 6.3 +/- 0.7 mg/dl (p <0.0001). Serum calcium levels fell during washout (9.8 +/- 0.4 to 8.9 +/- 0.3 mg/dl, p <0.004) and were unaffected by sevelamer hydrochloride. Sevelamer hydrochloride administration was associated with a 23.0 +/- 3.1% fall in total cholesterol, a 35.9 +/- 3.0% fall in LDL cholesterol, and a 35.2 +/- 5.3% fall in the LDL:HDL cholesterol ratio (p <0.001). There was no change in HDL ...

Energy Technology Data Exchange (ETDEWEB)

The investigations of lignite hydroliquefaction were aimed at improving reaction control in order to minimize residue and gas portion and hence increase the oil yield. To reach this goal, the process parameters were optimized and various catalysts tested for use in sump phase hydrogenation. Detailed investigations were also carried out on the problem of calcium carbonate agglomeration and the maceral decomposition behaviour of different lignite samples under hydrogenation conditions.

UK PubMed Central (United Kingdom)

1. We studied the effects of flash photolysis on the novel enantiomeric cardiac inotropes EMD 57033 (a calcium sensitizer) and EMD 57439 (a phosphodiesterase III inhibitor) in rat isolated ventricular...Full Text Available

DEFF Research Database (Denmark)

Urinary acidification, bone metabolism and urinary excretion of calcium and citrate were evaluated in 10 recurrent stone formers with incomplete renal tubular acidosis (iRTA), 10 recurrent stone formers with normal urinary acidification (NUA) and 10 normal controls (NC). Patients with iRTA had lower plasma standard bicarbonate after fasting (P <0.01) and lower urinary excretion of titratable acid (P <0.05) and citrate (P <0.01) compared with NUA patients and NC, and higher urinary excretion of ammonia (P <0.05) compared with NC (P <0.05). Hypercalciuria was found in 6 of 10 patients with iRTA compared with 3 of 10 with NUA, and 0 of 10 NC. The citrate/calcium ratio in urine was significantly reduced in iRTA compared with the value in NUA (P <0.01), and in NUA compared with NC (P <0.05). Biochemical markers of bone formation (serum osteocalcin) and bone resorption (urinary hydroxyproline) were significantly increased in iRTA ...

International Nuclear Information System (INIS)

The present study was undertaken to determine the involvement of calcium-protein kinase C pathway in the mechanism of action of Escherichia coli heat stable enterotoxin (STa) apart from STa-induced activation of guanylate cyclase in human colonic carcinoma cell line COLO-205, which was used as a model cultured cell line to study the mechanism of action of E. coli STa. In response to E. coli STa, protein kinase C (PKC) activity was increased in a time-dependent manner with its physical translocation from cytosol to membrane. Inhibition of the PKC activity in membrane fraction and inhibition of its physical translocation in response to IP_3-mediated calcium release inhibitor dantrolene suggested the involvement of intracellular store depletion in the regulation of PKC activity. Among different PKC isoforms, predominant involvement of calcium-dependent protein kinase C (PKC#alpha#) was specified using isotype-specific ...

Energy Technology Data Exchange (ETDEWEB)

The role of dietary calcium and phosphorus in modifying the intestinal absorption of lead and also the effect of lead ingestion on the metabolism of cholecalciferol were studied in chicks. The efficiency of absorption of /sup 203/Pb and /sup 47/Ca was increased when the animals were fed a low calcium diet and treated with cholecalciferol. The synthesis of the vitamin D-induced calcium-binding protein (CaBP) was correspondingly increased. When the chicks were depleted of vitamin D and repleted with 1,25-dihydroxycholecalciferol (1,25(OH)/sub 2/D/sub 3/) as their only source of the vitamin, the absorption of both /sup 47/Ca and /sup 203/Pb was unaffected by dietary calcium levels, and no change in CaBP levels occurred. Low dietary intake of phosphorus resulted in an increase in /sup 47/Ca and /sup 203/Pb absorption and in CaBP synthesis when the animals were treated with cholecalciferol. However, when the ...

UK PubMed Central (United Kingdom)

Gamma interferon plays an important role in regulating the functional properties of mononuclear phagocytes. In the present study, the role of activated protein kinases in the mechanism of action of...Full Text Available

UK PubMed Central (United Kingdom)

The interaction between Ca²⁺ sensors STIM1 and STIM2 and Ca²⁺ channel-forming protein ORAI1 is a crucial element of ...Full Text Available

UK PubMed Central (United Kingdom)

T-cell activation requires the influx of extracellular calcium, although mechanistic details regarding such activation are not fully defined. Here, we show that P2X₇ receptors play a key...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Nutrient elements contained in litter fall flux, that of uptake flux and turnover rate had generally tended to increase with the increase in the Warmth Index, while the amount of nutrient in the A[sub 0] horizon and nutrient use efficiency did not. However, it is suggested that topographic and climatic aridity, and the amount of available and exchangeable phosphorus, calcium and magnesium greatly affect the nutrient dynamics in a each forest ecosystem as the Warmth Index increases. (J.P.N.).

Science.gov (United States)

Several examples of agonist-directed trafficking of receptor signalling at 5-HT2A and 5-HT2C receptors have been reported that involve independent downstream transduction pathways. We now report the functional selectivity of a series of chemically diverse agonists at human (h)5-HT2A, h5-HT2B and h5-HT2C-VSV by examining two related responses, the upstream activation of Gq/11 proteins in comparison with its associated cascade of calcium mobilisation. At the h5-HT2A receptor, d-lysergic acid diethylamide (LSD) and the antiparkinsonian agents lisuride, bromocriptine and pergolide exhibit a higher potency for Gq/11 activation than calcium release in contrast with all the other tested ligands such as 5-HT, mCPP and BW723C86, that show an opposite preference of signalling pathway. Comparable observations are made at h5-HT2B and h5-HT2C-VSV receptors, suggesting a similar mechanism of functional selectivity for the three serotonin receptors. ...

Energy Technology Data Exchange (ETDEWEB)

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus (JCV), a human papovavirus. PML is a relatively rare disease seen predominantly in immunocompromised individuals and is a frequent complication observed in AIDS patients. The significantly higher incidence of PML in AIDS patients than in other immunosuppressive disorders has suggested that the presence of human immunodeficiency virus type 1 (HIV-1) in the brain may directly or indirectly contribute to the pathogenesis of this disease. In the present study the authors have examined the expression of the JCV genome in both glial and non-glial cells in the presence of HIV-1 regulatory proteins. They find that the HIV-1-encoded trans-regulatory protein tat increases the basal activity of the JCV late promoter, JCV{sub L}, in glial cells. They conclude that the presence of the HIV-1-encoded tat protein may positively ...

CERN Document Server

Regulatory genes called small RNAs (sRNAs) are known to play critical roles in cellular responses to changing environments. For several sRNAs, regulation is effected by coupled stoichiometric degradation with messenger RNAs (mRNAs). The nonlinearity inherent in this regulatory scheme indicates that exact analytical solutions for the corresponding stochastic models are intractable. Here, we present a variational approach to analyze a well-studied stochastic model for regulation by sRNAs via coupled degradation. The proposed approach is efficient and provides accurate estimates of mean mRNA levels as well as higher order terms. Results from the variational ansatz are in excellent agreement with data from stochastic simulations for a wide range of parameters, including regions of parameter space where mean-field approaches break down. The proposed approach can be applied to quantitatively model stochastic gene expression in complex ...

International Nuclear Information System (INIS)

The role of law in a federal regulatory agency is examined from an organizational perspective. While law is usually viewed in terms of its legal, political, and social value consequences, it is postulated that it also has significant organizational consequences. The impact of those consequences is examined in the case of a single agency, the US Nuclear Regulatory Commission. The legal process is shown to be a powerful organizational characteristic of the government administrative agency, beginning with statuatory definition of organization goals, structure, and procedures and ending with judicial review of actions. Agency lawyers are shown to represent a distinct professional subculture within this agency. Their values and orientations toward business, the role of regulation, and the role of nuclear utilities are different from the 95% of agency employees subculture based on a physical science/engineering background. It is concluded that agency ...

Energy Technology Data Exchange (ETDEWEB)

Our group is interested in evaluating early effects of dietary interventions on bone loss. Postmenopausal women lose bone following reduction in estrogen which leads to increased risk of fracture. Traditional means of monitoring bone loss and effectiveness of treatments include changes in bone density, which takes 6 months to years to observe effects, and changes in biochemical markers of bone turnover, which are highly variable and lack specificity. Prelabeling bone with {sup 41}Ca and measuring urinary {sup 41}Ca excretion with accelerator mass spectrometry provides a sensitive, specific, and rapid approach to evaluating effectiveness of treatment. To better understand {sup 41}Ca technology as a tool for measuring effective treatments on reducing bone resorption, we perturbed bone resorption by manipulating dietary calcium in rats. We used {sup 3}H-tetracycline ({sup 3}H-TC) as a proxy for {sup 41}Ca and found that a single dose is feasible to study bone ...

Energy Technology Data Exchange (ETDEWEB)

The possibility of obtaining high yields of hydrogen through the exposure of calcium hydroxide to natural uranium fission fragments is confirmed experimentally. The amounts of hydrogen obtained in some experiments were determined not only from the mass-spectrometry data, but also with the use of standard chemical analysis methods. The radiolytic hydrogen yield averaged over six independent experiments comprises 20.41 hydrogen molecules per 100 eV of absorbed fission fragment energy. The corresponding energy efficiency makes up to 60.62. Since on interaction with water or water vapor calcium hydroxide enters into the exothermal reaction to liberate 15.6 kcal/mole, it can easily be regenerated; this was attested to by one of irradiation experiments. Therefore, in the long run, we are dealing with a radiolytic decomposition of water at low temperatures or at temperatures readily available with modern reactor engineering techniques. Comparison of ...

Energy Technology Data Exchange (ETDEWEB)

Although it has been established that lead is transferred in milk from mother to suckling offspring, the physiological processes and parameters involved are not well understood. Single i.v. doses (0.2 mg/kg) or p.o. doses (2 mg/kg) of radiolabeled lead were administered to lactating and nonlactating female mice, and lead concentrations in blood, plasma, and milk were determined during a 21-day period. Large differences in lead elimination were observed between lactating and nonlactation mice. A significant fraction (25%) of the initial maternal dose (absorbed dose) was transferred to the suckling pups. The ratio of lead concentration in milk to lead concentration in plasma was found to be nearly constant over time. However, the milk-to-blood concentration ratios decreased during the same period. Furthermore, the concentration of lead in milk exceeded the plasma concentration by a factor of approximately 25, indicating that there is a physiological process(es) which establishes a large ...

Science.gov (United States)

A miniature, high-voltage, thermally activated battery has been developed. This battery weighs 41 grams, occupies a volume of 16.4 cu cm, and contains two separate 500-v channels, each designed to charge a 5.25 microfarad capacitor within 300 milli-seconds and remain operational under a 640-kohm load for a minimum of 28 seconds over the temperature range from +16 to +71 C. The electrochemical system utilizes a calcium anode, LiCl-KCl molten salt electrolyte, a CaCrO4-K2CrO4 mixture as the depolarizer or active cathode material, and an iron cathode. The depolarizer and electrolyte, along with a silica binder, are formed into homogeneous pellets, and these pellets are stacked alternately with calcium-iron bimetal disks in beryllium oxide tubes to form cell stacks. The cells are activated by an iron-potassium perchlorate pyrotechnic heat source external to the BeO tubes.