calcification share genetic: Topics by WorldWideScience.org

Highly lytic and persistent lentiviruses naturally present in sheep with progressive pneumonia are genetically distinct.

The phylogeny and taxonomy of mammalian species were originally based upon shared or derived morphological characteristics. However, genetic analyses have more recently played an increasingly important...Full Text Available

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Incorporating Traditional Knowledge in an International Regime on Access to Genetic Resources and Benefit Sharing: Problems and Prospects

Ovine and caprine lentiviruses share the capacity to induce slowly progressive and inflammatory diseases of the central nervous system (leukoencephalitis or visna), lungs (progressive pneumonia or maedi),...Full Text Available

1984-11-01

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British Library Electronic Table of Contents (United Kingdom)

The Seventh Meeting of the Conference of the Parties (2004) of the Convention on Biological Diversity established a mandate for the negotiation of an international regime on Access to Genetic Resources and Benefit Sharing arising from their utilization. Negotiations have been proceeding and have entered the final phase. Seven working group meetings have been held to date and there is expectation that an instrument will emerge by the final deadline - the Tenth Meeting of the Conference of the Parties in Nagoya, Japan in October 2010. A key component singled out for inclusion in the international regime relates to the recognition and protection of the rights of indigenous and local communities (ILCs) over their traditional knowledge (TK) associated with genetic resources. The Ninth Meeting o...

2010-01-01

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Incidental orbital calcifications on computed tomography scans; Calcificacoes orbitarias incidentais na tomografia computadorizada

Extensive peritoneal calcifications associated with continuous ambulatory peritoneal dialysis

We retrospectively studied the computed tomography scans of the orbit in 75 patients in order to identify the presence of incidental calcifications (scleral and trochlear apparatus calcifications.). These imaging findings should integrate the vast list of differential diagnosis of orbital calcifications, as they may help radiologists to distinguish these calcifications from orbital foreign bodies. (author)

2001-02-01

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Introduction to Genetic Algorithms

Peritoneal calcification, which can lead to intestinal obstruction and potentially lethal hemoperitoneum, is a rare complication of continuous ambulatory peritoneal dialysis. We describe a case in which extensive peritoneal calcification had arisen for this reason. Although the patient was asymptomatic, extensive calcification was present on the parietal and visceral peritoneum, including the hepatic and splenic surface. (author)

2000-07-01

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Detection of intracardiac calcification using Fuji computed radiography

Introduction to Genetic Algorithms

2007-01-01

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Hypoparathyroidism and intracerebral calcification in patients with beta-thalassemia major

Fuji Computed Radiography (FCR) was evaluated for detection of intracardiac calcification as compared with conventional radiography in 77 patients. Intracardiac calcification was found in 37 patients (left coronary artery: 31, right coronary artery: 11, valve: 9) on cine-fluorography. The sensitivity for detecting these calcified foci with FCR was higher than conventional screen-film method. Especially, sensitivity for detecting left coronary artery calcification with FCR was significantly higher than conventional method (71 %, 32 %) (p < 0.01), Fine anatomical details of calcification were well shown on FCR. Chest radiography using FCR is of great use for detection of intracardiac calcification. (author).

1986-01-01

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Cerebral calcification and learning disabilities following cranial irradiation for medulloblastoma.

Background: Hypoparathyroidism is one of the most important endocrine complications of thalassemia major. This study was conducted to evaluate the prevalence of intracerebral calcifications in patients with thalassemia with and without hypoparathyroidism. Methods: 47 beta-thalassemia patients with hypoparathyroidism underwent a brain CT scan to investigate the presence and extent of intracerebral calcification. 30 age- and sex-matched beta-thalassemic patients with normal parathyroid function who had undergone brain CT for headache, or some other minor neurologic problems were also enrolled in the study serving as controls. The amount of intracerebral calcification, hematologic parameters, and some clinical findings were compared between both groups. Results: Intracerebral calcification was present in 54.2% of beta-thalassemia patients with hypoparathyroidism. The most frequent sites of ...

2009-06-15

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The epidemiology of Graves' disease: Evidence of a genetic and an environmental contribution

Six children who received craniospinal irradiation for medulloblastoma when they were under 10 years of age developed learning disabilities. Four exhibited associated temporal lobe calcification on...Full Text Available

1990-12-01

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British Library Electronic Table of Contents (United Kingdom)

Previous family and twin studies have indicated that Graves' disease has a heritable component. Family studies have also shown that some autoimmune disease cluster in families and genetic studies have been able to show shared susceptibility genes. In the present nation-wide study we describe familial risk for Graves' disease among parents and offspring, singleton siblings, twins and spouses with regard to age of onset, gender and number and type of affected family members. Additionally familial association of Graves' disease with any of 33 other autoimmune and related conditions was analyzed. The Swedish Multigeneration Register on 0-75-year-old subjects was linked to the Hospital Discharge Register from years 1987-2007. Standardized incidence ratios (SIRs) were calculated for individuals ...

2010-01-01

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Evaluation of calcification in pulmonary nodules using bone images obtained with single exposure energy subtraction

Evaluation of calcification in pulmonary nodules using bone images obtained with single exposure energy subtraction

Bone images obtained by single exposure dual energy subtraction with computed radiography, a new image processing method, were evaluated for the detectability of calcification in lung nodules in both phantom and clinical studies. In the phantom study, five simulated nodules containing known and uniformly distributed amounts of calcium hydroxide were placed in a human chest phantom and images were obtained the following five techniques: (1) conventional radiography (CXR), (2) low kV conventional radiography (Low), (3) Fuji computed radiography (FCR), (4) bone images with conventional singles exposure energy subtraction (ES) and (5) bone image with fine single exposure energy subtraction (FES). The detectability of calcification in the simulated nodules was evaluated by six radiologists using ROC analysis and two-way analysis of variance. In the clinical study, images of 42 lung nodules (21 calcified lung nodules and 21 non-calcified nodules), in ...

1995-08-01

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Feeding ecology of Xenoturbella bocki (phylum Xenoturbellida) revealed by genetic barcoding

Bone images obtained by single exposure dual energy subtraction with computed radiography, a new image processing method, were evaluated for the detectability of calcification in lung nodules in both phantom and clinical studies. In the phantom study, five simulated nodules containing known and uniformly distributed amounts of calcium hydroxide were placed in a human chest phantom and images were obtained the following five techniques: 1) conventional radiography (CXR), 2) low kV conventional radiography (Low), 3) Fuji computed radiography (FCR), 4) bone images with conventional singles exposure energy subtraction (ES) and 5) bone image with fine single exposure energy subtraction (FES). The detectability of calcification in the simulated nodules was evaluated by six radiologists using ROC analysis and two-way analysis of variance. In the clinical study, images of 42 lung nodules (21 calcified lung nodules and 21 non-calcified nodules), in ...

1995-01-01

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British Library Electronic Table of Contents (United Kingdom)

Abstract The benthic marine worm Xenoturbella is frequently contaminated with molluscan DNA, which had earlier caused confusion resulting in a suggested bivalve relationship. In order to find the source of the contaminant, we have used molluscan sequences derived from Xenoturbella and compared them to barcodes obtained from several individuals of the nonmicroscopic molluscs sharing the same environment as Xenoturbella. Using cytochrome oxidase 1, we found the contaminating sequences to be 98% similar to the bivalve Ennucula tenuis. Using the highly variable D1-D2 region of the large ribosomal subunit in Xenoturbella, we found three distinct species of contaminating molluscs, one of which is 99% similar to the bivalve Abra nitida, one of the most abundant bivalves in the Gullmarsfjord where...

2008-01-01

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Absence of the A4 peptide in the G4 glycinin subunit of soybean cultivar Enrei is caused by a point mutation in the Gy4 gene

Scientific Electronic Library Online (English)

Abstract in english Functional properties of soy proteins for food are closely related to the composition of their storage protein subunits. Using base excision sequence scanning (BESS), we show that the absence of the A4 peptide in the G4 glycinin subunit of the soybean (Glycine max L.) cultivar Enrei was caused by the same point mutation in the Gy4 gene as previously reported in the soybean cultivar Raiden. Although the genetic relationship between Raiden and Enrei is not known, the same p (more) oint mutation in their Gy4 genes may indicate that they probably share a related origin. The application of BESS to identify single nucleotide polymorphisms (SNPs) as co-dominant markers for marker-assisted selection (MAS) of a recessive null allele is also discussed.

2005-09-01

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The ZNF804A gene: characterization of a novel neural risk mechanism for the major psychoses.

Renal bone disease and extraskeletal calcification during dialysis and after transplantation

Schizophrenia and bipolar disorder share genetic risk, brain vulnerability, and clinical symptoms. The ZNF804A risk variant, rs1344706, confers susceptibility for both disorders. This study aimed to identify neural mechanisms common to both schizophrenia and bipolar disorder through this variant's potential effects on cortical thickness, white matter tract integrity, and cognitive function. Imaging, genetics, and cognitive measures were ascertained in 62 healthy adults aged between 18 and 59 years. High-resolution multimodal MRI/DTI imaging was used to measure cortical thickness and major frontotemporal and interhemispheric white matter tracts. The general linear model was used to examine the influence of the ZNF804A rs1344706 risk variant on cortical thickness, white matter tract integrity, and cognitive measures. Individuals homozygous for the risk variant ('A' allele) demonstrated reduced cortical gray matter thickness ...

2011-04-27

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Pop : Phonophani "Genetic Engineering" / Erkki Luuk

The author reports 10 studies concerning the diagnosis of renal osteodystrophy and extraskeletal calcification in patients on maintenance hemodialysis as well as some aspects of persistent hyperparathyroidism after renal transplantation. The majority of the studies focus on the value of bone scintigraphy with Tc-99m HEDP in the diagnosis of these disorders. (Auth.).

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Index Scriptorium Estoniae

Heliplaadist

2001-01-01

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XML

Indian Academy of Sciences (India)

with whom do you need to share your data or metadata? ...

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Calcified metastases of the kidney. Etiology, pathogenesis, CT findings and diagnostic problems; Metastasi renali calcificate: eziologia, patogenesi, aspetti con tomografia computerizzata e diagnostica differenziale

Calcification of subcutaneously implanted type I collagen sponges. Effects of formaldehyde and glutaraldehyde pretreatments.

Aim of the work was to describe computerised tomography (CT) findings of calcified renal metastases focusing on differential diagnosis problems. Abdominal CT scans of 8000 patients with tumor, performed from 1984 to 1998, have been retrospectively reviewed. [Italian] Scopo del lavoro e' quello di descrivere gli aspetti con tomografia computerizzata delle metastasi renali calcificate enfatizzando le problematiche diagnostico differenziali. Sono state valutate retrospettivamente le indagini TC addominali di 8000 pazienti affetti da tumore nel periodo 1984-1998, analizzando le lesioni calcificate riscontrate.

2000-03-01

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Mitochondrial genetic damage induced in yeast by a photoactivated furocoumarin in combination with ethidium bromide or ultraviolet light

Although collagen-containing implants are widely used in various surgical applications, there has been relatively little attention paid to the possibility that this type of biomaterial may undergo pathologic...Full Text Available

1986-01-01

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Genetic organization of Bungarus multicinctus protease inhibitor-like proteins.

Ethidium bromide (EB) and ultraviolet light (UV) in combination are known to produce a synergistic induction of 'petite' mutants in yeast. Two other agents were combined with EB, 3-Carbethoxypsoralene (3 CPs) activated by 365 nm light or #gamma# rays. EB in combination with 3 CPs also resulted in an enhanced production of 'petite' mutants. After the photoaddition of 3 CPs in exponential phase cells, recovery of the 'petite' mutation during dark liquid holding was inhibited by the presence of EB producing an enhanced number of 'petite' mutants. The behavior of mitochondrial antibiotic resistance markers after individual and combined treatments with EB and 3 CPs indicates a random loss of markers after EB and a preferential loss of a certain region for the 3 CPs photoaddition. The combination of the two agents leads to an additivity of total drug marker losses rather than a synergistic loss. The combination of EB with #gamma# rays produced no enhancement in 'petite' induction. A ...

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Genetics, Genomics, and Molecular Biology

The structural organization of the genes encoding Bungarus multicinctus protease inhibitor-like proteins (PILPs), PILP-1, PILP-2 and PILP-3, are reported in this study. Unlike PILP-2 and PILP-3, recombinant PILP-1 exhibited inhibitory activity on trypsin. PILP genes and B chain genes shared identical organization with three exons interrupted by two introns in similar positions. On the contrary, intron 1 of these genes had a similar size, a notable variation with the size of intron 2 was observed. It was found that two regions at the second intron of B1 chain and B2 chain genes were absent in that of PILP genes. Noticeably, intronic insertion in the second intron of B chain genes appeared in the promoter region of PILP-1 gene, but not in that of PILP-2 and PILP-3 genes. Comparative analyses of PILP genes and B chain genes showed that the protein-coding regions of the exons are more diverse than introns, except for in the signal peptide domain. These results suggest ...

2008-03-27

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Estimating Load-Sharing Properties in a Dynamic Reliability System

Genetics, Genomics, and Molecular Biology USGS scientists develop and integrate new genetic and molecular techniques into systematic analyses to describe individuals and populations of fish .....

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New frontiers in competition for pollination

An estimator for the load share parameters in an equal load-share model is derived based on observing k-component parallel systems of identical components that have a continuous...Full Text Available

2005-01-01

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Technology assessment and resource allocation for predictive genetic testing: A study of the perspectives of Canadian genetic health care providers

BackgroundCo-flowering plant species frequently share pollinators. Pollinator sharing is often detrimental to one or more of these species, leading to competition for pollination....Full Text Available

2009-06-01

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Molecular Genetics of Emericella nidulans Sexual Development

BackgroundWith a growing number of genetic tests becoming available to the health and consumer markets, genetic health care providers in Canada are faced with the challenge of developing...Full Text Available

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Genetic screening: The vista of genomic medicine

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2009-09-01

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The role of Computerized Tomography in osteoid-osteoma diagnosis

The accelerating development of biochemical and DNA-based diagnostic tests for human genetic conditions in the last decade has engendered a revolution in genetic diagnosis. Both genetic testing and...Full Text Available

2011-01-01

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Theoretical considerations for X-ray phase contrast mammography by Thomson source

Alcaptonuria is a rare autosomal recessive metabolic disease, due to the lack of homogentisic acid oxidase. The following accumulation of homogentisic acid brings about a black discoloration of both the urine alcaptonuria) and connective tissue (ochronosis). The ochronotic alterations into joint cartilages cause degenerative arthropathy and osteopenia. The radiological features of three unrelated cases of alcaptonuria are reported. Radiographic abnormalities of ochconotic arthropathy are found in both the spine and the extraspinal joints. In the spine, the progressive calcification and ''vacuum'' phenomenon of disc spaces are the most characteristic findings. Disc space narrowing is associated with calcification and marginal sclerosis of vertebral bodies and is accentuated by osteopenia. Osteophytes are usually absent or of small size; neverthless progressive formation of marginal intervertebral bridges and obliteration of disc spaces at ...

1988-01-01

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Water Demand and Supply Stability Analysis Using Shared Vision Model

The advent, in the near future, of compact X-ray sources like Thomson Back-Scattering (TBS) will allow the clinical application of advanced X-ray imaging techniques, such as phase contrast, with higher sensitivity and lower impact in terms of dose delivery. In this work, we theoretically investigated the possibility of using such sources for phase contrast imaging of micro-calcifications included in a breast tissue. In our study we analyzed the phase and amplitude distribution of the TBS source and we showed that this source can be used for phase contrast imaging since the source coherence at the sample position is sufficiently high for achieving good contrast and micrometer spatial resolution. Indeed the spatial coherence of a TBS source is closer to that of a synchrotron radiation source, and much better than that of a laboratory source. Moreover, we showed the advantages of phase imaging with respect to standard absorption imaging, in the specific case of ...

2009-09-01

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Don't walk like an Egyptian : Coping with shared attention in a mobile 3D system

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2004-07-01

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Norwegian Open Research Archives (NORA)

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Increased levels of the calcification marker Matrix Gla Protein and the inflammatory markers YKL-40 and CRP in patients with type 2 diabetes and ischemic heart disease

CT scan findings in cerebral paragonimiasis

Objective and designLow grade inflammation is of pathogenic importance in atherosclerosis and in the development of cardiovascular disease (CVD) and type 2 diabetes (T2D). Matrix...Full Text Available

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Implementing Explicit and Finding Implicit Sharing in Embedded DSLs

Computed tomography was performed on 5 patients with chronic cerebral paragonimiasis. CT showed solitary or multiple, amorphous, round, or oval calcifications, and ventricular enlargement in all 5 cases. A large low-density area is also found in 4 of the 5 cases. These CT findings are compatible with previously reported findings of simple X-ray films of the skull, pneumoencephalography, and pathological studies. (author).

1982-01-01

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Genomic analysis of the symbiotic marine crenarchaeon, Cenarchaeumsymbiosum

Aliasing, or sharing, is prominent in many domains, denoting that two differently-named objects are in fact identical: a change in one object (memory cell, circuit terminal, disk block) is instantly reflected in the other. Languages for modelling such domains should let the programmer explicitly define the sharing among objects or expressions. A DSL compiler may find other identical expressions and share them, implicitly. Such common subexpression elimination is crucial to the efficient implementation of DSLs. Sharing is tricky in embedded DSL, since host aliasing may correspond to copying of the underlying objects rather than their sharing. This tutorial summarizes discussions of implementing sharing in Haskell DSLs for automotive embedded systems and hardware description languages. The technique has since been used in a Haskell SAT solver and the DSL for music ...

2011-01-01

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Genome Sequence of a Lancefield Group C Streptococcus zooepidemicus Strain Causing Epidemic Nephritis: New Information about an Old Disease

Crenarchaea are ubiquitous and abundant microbial constituents of soils, sediments, lakes and ocean waters, yet relatively little is known about their fundamental evolutionary, ecological, and physiological properties. To better describe the ubiquitous nonthermophilic Crenarchaea, we analyzed the genome sequence of one representative, the uncultivated sponge symbiont, Cenarchaeum symbiosum. C. symbiosum genotypes coinhabiting the same host partitioned into two dominant populations, corresponding to previously described a- and b-type ribosomal RNA variants. Although synthetic, overlapping a- and b-type ribotypes harbored significant genetic variability. A single tiling path comprising the dominant a-type genotype was assembled, and used to explore the biological properties of C. symbiosum and its planktonic relatives. Out of a total of 2,066 predicted open reading frames, 36% were more highly conserved with other Archaea. The remainder partitioned between bacteria ...

2006-06-24

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Exploiting rice-sorghum synteny for targeted development of EST-SSRs to enrich the sorghum genetic linkage map.

Outbreaks of disease attributable to human error or natural causes can provide unique opportunities to gain new information about host-pathogen interactions and new leads for pathogenesis research. Poststreptococcal glomerulonephritis (PSGN), a sequela of infection with pathogenic streptococci, is a common cause of preventable kidney disease worldwide. Although PSGN usually occurs after infection with group A streptococci, organisms of Lancefield group C and G also can be responsible. Despite decades of study, the molecular pathogenesis of PSGN is poorly understood. As a first step toward gaining new information about PSGN pathogenesis, we sequenced the genome of Streptococcus equi subsp. zooepidemicus strain MGCS10565, a group C organism that caused a very large and unusually severe epidemic of nephritis in Brazil. The genome is a circular chromosome of 2,024,171 bp. The genome shares extensive gene content, including many virulence factors, with ...

2008-08-21

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The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics

The sequencing and detailed comparative functional analysis of genomes of a number of select botanical models open new doors into comparative genomics among the angiosperms, with potential benefits for improvement of many orphan crops that feed large populations. In this study, a set of simple sequence repeat (SSR) markers was developed by mining the expressed sequence tag (EST) database of sorghum. Among the SSR-containing sequences, only those sharing considerable homology with rice genomic sequences across the lengths of the 12 rice chromosomes were selected. Thus, 600 SSR-containing sorghum EST sequences (50 homologous sequences on each of the 12 rice chromosomes) were selected, with the intention of providing coverage for corresponding homologous regions of the sorghum genome. Primer pairs were designed and polymorphism detection ability was assessed using parental pairs of two existing sorghum mapping populations. About 28% of these new markers detected ...

2009-08-08

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Genetically-engineered mouse models for pancreatic cancer: Advances and current limitations

Mouse genetic resources include inbred strains, recombinant inbred lines, chromosome substitution strains, heterogeneous stocks, and the Collaborative Cross (CC). These resources were generated through...Full Text Available

2007-07-01

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From Classical Genetics to Quantitative Genetics to Systems Biology: Modeling Epistasis

Recently, there has been significant progress in the development of genetically-engineered mouse (GEM) models. By introducing genetic alterations and/or signaling alterations of human pancreatic cancer...Full Text Available

2011-05-10

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Evolving hard problems: Generating human genetics datasets with a complex etiology

Gene expression data has been used in lieu of phenotype in both classical and quantitative genetic settings. These two disciplines have separate approaches to measuring and interpreting epistasis, which...Full Text Available

2008-03-01

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Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study

BackgroundA goal of human genetics is to discover genetic factors that influence individuals' susceptibility to common diseases. Most common diseases are thought to result from the...Full Text Available

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THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF EVOLUTIONARY CHANGE MEDIATED BY PHENOTYPIC ...

Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which genetic association-studies have successfully...Full Text Available

2010-07-01

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Ovine reference materials and assays for prion genetic testing

... 1111/j.1558-5646.2007.00203.x THE BALDWIN EFFECT AND GENETIC ASSIMILATION: REVISITING TWO MECHANISMS OF ... to phenotypic plast...

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Molecular Genetics and Carcinogenesis Section

BackgroundGenetic predisposition to scrapie in sheep is associated with several variations in the peptide sequence of the prion protein gene (PRNP). DNA-based tests...Full Text Available

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Mice as a Mammalian Model for Research on the Genetics of Aging

The Molecular Genetics and Carcinogenesis Section conducts studies using human epithelial cells to assess: activation of proto-oncogenes by chemical and physical carcinogens; inactivation and dysregulation of tumor suppressor genes by chemical and physical

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Liver Carcinogenesis Unit

Mice are an ideal mammalian model for studying the genetics of aging: considerable resources are available, the generation time is short, and the environment can be easily controlled, an important...Full Text Available

2011-02-08

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Detection of genetic mutations in repetitive DNA sequences in somatic human cells after low-dose irradiation

The Liver Carcinogenesis Section uses the modern technologies of molecular biology, cell biology, protein chemistry and genetics to investigate the biochemical and genetic pathways involved in human liver cancer.

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Browse Conditions - Genetics Home Reference

... 3-89701-147-6 0949-2224 245 p. animal cells dna genetic radiation effects

1998-03-01

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APPLICATION OF RAPD IN THE DETERMINATION OF GENETIC FIDELITY IN MICROPROPAGATED DROSERA PLANTLETS

Home A service of the U.S. National Library of Medicine® Home Conditions Genes Chromosomes Handbook Glossary Resources Genetic Conditions > Browse Conditions 1-9 | A | B | C...

2011-09-24

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Tissue distribution of brain-thymus shared antigens recognized by anti-brain xenosera in the rat, dog and man.

... K. Ishii. 1998. Determination of genetic stability in long-term micropropagated shoots of Pinus thunbergii Parl. using RAPD markers. Plant ... ...

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Information Sharing in the Era of WikiLeaks: Balancing Security and Collaboration.

A comparative and quantitative study of the tissue distribution of brain-thymus shared antigens was carried out using rabbit antisera to rat, dog and human brain homogenates, assayed on rat, dog and...Full Text Available

1979-03-01

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Induced voltage in a shared corridor

As the IC Information Sharing Executive (IC ISE), my main focus today concerns classified information--and, in particular, information that is derived from intelligence sources and methods, or information that is reflected in the analytic judgments and as...

2011-01-01

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The induction of voltages on pipelines and railroad signal wires can be a problem when high-voltage transmission lines share the right of way. A handbook and two computer programs provide the analytic tools for utilities to avoid the problem.

1983-10-01

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The EMSL Collaboratory

Models for Work Backlogs at Computers that Time-Share ...

sharing data and computational resources, and accessing information in digital libraries." Bill Wulf (1989) In a Collaboratory, the presentation/meeting concept embodied...

2011-10-07

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A Medical Integration Framework based on XML for efficient exchange and sharing of Electronic Health Record using HL7

... DATA PROCESSING TERMINALS, *REMOTE TERMINALS, DATA PROCESSING, STOCHASTIC PROCESSES, QUEUEING THEORY, TIME ...

1977-07-01

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Full Text Available

2002-10-01

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Primaquine

Population genetic structure of savannah elephants in Kenya: conservation and management implications

... oxygen to the tissues in the body),nicotinamide adenine dinucleotide (NADH) deficiency (a genetic condition), glucose-6- ...

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Genome structure of cotton revealed by a genome-wide SSR genetic map constructed from a BC₁population between gossypium hirsutum and G. barbadense

Udgivelsesdato: null-null

2008-01-01

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Genetically and somatically significant radiation doses in the radiotherapy of inflammatory and degenerative diseases

BackgroundCotton, with a large genome, is an important crop throughout the world. A high-density genetic linkage map is the prerequisite for cotton genetics and breeding. A genetic...Full Text Available

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Genetic Stability of Magnaporthe oryzae during Successive Passages through Rice Plants and on Artificial Medium

... pathological changes patients radiation protection radiotherapy diseases

1982-10-25

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Genetic Characterization of Encephalomyocarditis Virus Isolated from Aborted Swine Fetus in Korea

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2010-12-01

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Disturbed tooth formation by /sup 60/Co-gamma-ray radiation

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2006-10-01

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Computed tomography of the mediastinal tumor

The molar of guinea pigs was irradiated with /sup 60/Co-..gamma.. ray for daily observations of the manifestation of disturbed tooth formation by microradiography and the time registration by tetracycline-labelling. Irradiation first injured young blast cells of the dentin in the growth phase, dental pulp cells, and cells of the enamel. The portion composed of injured cells formed a depressed ''constriction'' from the dental pulp side toward the border between the enamel and dentin. The cells of the enamel injured by irradiation in the growth phase later formed a very thin irregular stroma. In contrast, cells in the differentiation or subsequent phase at the time of irradiation and cells probably having started to grow after irradiation proceeded with formation of a normal stroma and calcification. No uniform relation was obtained between the histological staining of the organic stroma of normal or abnormal dentin and ...

1982-02-01

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PET/CT cardiology: an area whose boundaries are still out of sight

Forty-one cases of mediastinal tumor examined by computed tomography were reviewed. CT findings of the mediastinal malignancy were as follows: 1) inhomogeneous density on contrast CT, 2) equivocaton of fat plane surrounding the tumor, 3) irregular margin. Benign teratoma had smooth margin and included fat or calcification density. Mediastinal seminoma was observed as a lobulated mass with no calcification on CT. These findings were similar to the patterns of malignant thymoma or lymphoma. Consequently, it was very difficult to differentiate between malignant thymoma and malignant lymphoma by CT. According to our data, malignant thymoma tended to expand to only one side of the anterior mediastinum and to invade the anterior chest wall. On the other hand, malignant lymphoma of anterior medistinal type expanded into the trachea and the superior vena cava. In patients with sarcoidosis, the enlargement of bilateral hilar lymph nodes was commonly ...

1984-12-01

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Dextranomer/hyaluronic acid copolymer (Deflux) implants mimicking distal ureteral calculi on CT

Positron emission tomography (PET) and X-ray computed tomography (CT) performed with PET/CT cameras allow us to obtain concurrently information on the presence and degree of alterations of myocardial perfusion and metabolism and on coronary arteries calcification. Furthermore, by gated myocardial perfusion studies, PET may provide crucial information on regional coronary blood flow reserve and endothelial dysfunction. A number of recent papers provide some insight on the potential of PET/CT in cardiology and in the assessment of various cardiovascular diseases including various types of vasculitis and metabolic diseases.

2006-05-01

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Mechanism of sup(99m)Tc-methylene diphosphonate (sup(99m)Tc-MDP) localization in experimental studies of bone tumors. Microautoradiography method

Periureteral or subtrigonal injection of dextranomer/hyaluronic acid (Dx/HA) copolymer (Deflux, Q-Med, Uppsala, Sweden) is an increasingly common endoscopic treatment for vesicoureteral reflux. We report a confusing radiographic finding of bilateral calcified Dx/HA injections initially thought to represent bilateral distal ureteral stones in a boy who presented with intermittent periumbilical pain. Urologists, radiologists, and emergency room physicians should be aware of the potential for calcification of ureteral implants of Dx/HA, and of the potentially confusing radiographic images that may result. (orig.)

2008-01-15

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Mechanism of sup(99m)Tc-methylene diphosphonate (Tc-MDP) localization in clinical and experimental studies of bone tumors

(Materials and Methods) (I) VX/sub 2/ carcinoma was transplanted to the rabbit tibia, sup(99m)Tc-MDP was intravenously injected when bone destruction was radiologically seen. Preoperative scintigraphs, postoperative one of the resected tibia and fibra and scintigraphs of sliced tumor were compared with each other. Tissue fragments were collected from the sliced tumor, and RI was measured to compare concentration rates at different parts together with histological investigations. (II) Tetracycline was given to the rabbit of Experiment (I) to compare with the concentration of sup(99m)Tc-MDP. (III) Microautoradiography method was done on the experimental animals for investigation of the concentration of sup(99m)Tc-MDP. (Results) (I) Localization of sup(99m)Tc-MDP was increased at the sites of tumorous bone formation, of reactive bone formation at tumor edges, and of cartilage calcification, with little concentration at tumor cells or necrotic tissue. (II) Deposition ...

1981-12-01

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Clinical application of dual energy subtraction in direct digital radiography of chest

Tc-MDP 10mCi was intravenously given preoperatively to 20 patients with primary bone tumors and 1 with a metastatic bone tumor. Preoperative and postoperative scintigraphs of resected tumor and scintigraphs of sliced tumor were compared. Tissue fragments were collected from the sliced tumor, and RI measured to compare concentration rates at different areas. Histological investigations were also done. Localization of Tc-MDP was increased at sites of tumorous bone formation, of reactive bone formation at tumor edges, and of cartilage calcification, with little concentration at tumor cells or necrotic tissue. VX/sub 2/ carcinoma was transplanted into the rabbit tibia, Tc-MDP was intravenously injected when bone destruction was radiologically evident, and investigations were done as in the clinical cases. In experimental bone tumor, increased uptake localization of Tc-MDP was much the same as in clinical cases. Tetracycline was given to the rabbit of Experiment to ...

1981-06-01

70

Local chromatin structure of heterochromatin regulates repeatedDNA stability, nucleolus structure, and genome integrity

Objective: To discuss the clinical application value of dual energy subtraction (DES) in direct digital radiography of chest. Methods: 83 cases of chest digital radiography(DR) using double-energy subtraction (DES) were randomly selected, and three posterior-anterior (PA) chest films (standard image, bone image and soft tissue image) were obtained in each case, which is so called 'bone and soft tissue separated' technology. Results: With the aid of double energy subtraction (DES), the bony chest was subtracted, the sensitivity and specificity of pulmonary calcification were improved, and sensitivity of pulmonary nodes was also improved, enhancing the distinction between pulmonary benign or malignant lesions, enlightening the diagnosis of chest cage lesions, and showing a clear superiority in the detection of pulmonary nodes comparing to common chest films. The double energy subtraction (DES) films showed a higher diagnostic accuracy in the detection of bony cage ...

2009-02-01

71

Genetic diversity among Angus, American Brahman, Senepol and Romosinuano cattle breeds:

Heterochromatin constitutes a significant portion of the genome in higher eukaryotes; approximately 30% in Drosophila and human. Heterochromatin contains a high repeat DNA content and a low density of protein-encoding genes. In contrast, euchromatin is composed mostly of unique sequences and contains the majority of single-copy genes. Genetic and cytological studies demonstrated that heterochromatin exhibits regulatory roles in chromosome organization, centromere function and telomere protection. As an epigenetically regulated structure, heterochromatin formation is not defined by any DNA sequence consensus. Heterochromatin is characterized by its association with nucleosomes containing methylated-lysine 9 of histone H3 (H3K9me), heterochromatin protein 1 (HP1) that binds H3K9me, and Su(var)3-9, which methylates H3K9 and binds HP1. Heterochromatin formation and functions are influenced by HP1, Su(var)3-9, and the RNA interference (RNAi) pathway. My thesis project ...

2007-05-05

72

British Library Electronic Table of Contents (United Kingdom)

Summary The objective of this study was to quantify the genetic diversity among breeds under evaluation for tropical adaptability traits that affect the performance of beef cattle at the USDA/ARS SubTropical Agricultural Research Station (STARS) near Brooksville, FL, USA. Twenty-six microsatellite loci were used to estimate parameters of genetic diversity among the breeds American Brahman, Angus, Senepol and Romosinuano; the latter was comprised of two distinct bloodlines (Costa Rican and Venezuelan). Genotypes of 47 animals from each of these STARS herds were analysed for genetic diversity and genetic distance. Using two methods, the greatest genetic distance was detected between the Costa Rican line of Romosinuano and the Senepol. Gene diversity ranged between 0.64 (Costa Rican line of R...

2007-01-01

73

Entanglement-secured single-qubit quantum secret-sharing

Industrial research - Information Centre - Research & Innovation - European Commission

In single-qubit quantum secret sharing, a secret is shared between N parties via manipulation and measurement of one qubit at a time. Each qubit is sent to all N parties in sequence; the secret is encoded in the first participant's preparation of the qubit state and the subsequent participants' choices of state rotation or measurement basis. We present a protocol for single-qubit quantum secret sharing using polarization entanglement of photon pairs produced in type-I spontaneous parametric downconversion. We investigate the protocol's security against eavesdropping attack under common experimental conditions: a lossy channel for photon transmission, and imperfect preparation of the initial qubit state. A protocol which exploits entanglement between photons, rather than simply polarization correlation, is more robustly secure. We implement the entanglement-based secret-sharing protocol with 87% ...

2011-01-01

74

Wastenet

... These highly energy efficient panels of organic luminescence are far removed from the bulbs and filaments of current lighting technology. 28-04-11 Source : Star Projects Results: 1-10 of 251 Page(s) 1 of 26 Next Limit search to articles published within the last Month Quarter Year No limit Follow us on Facebook Share an article You can share any article via social networking sites or email it to friends. Click the SHARE icon, select from the list that appears, and the article ...

75

Cost savings through effective use of network resources

Volume IIr - NASA Technical Report Server (NTRS)

The role of computers has become increasingly important for oil and gas field research and operations support. Today, the computer network is an integral part of the increasingly complex computing environment that exists in many companies. Computer networks allow users to efficiently share information, software, and hardware to support critical global communication needs. Because users are able to share software and hardware, the use of computer networks can also result in significant cost savings. This paper describes typical network loading and demand levels for shared software applications on a computer network that has been used for several years.

1994-12-31

76

Transvaal Consolidated Land and Exploration Company, Limited

f4. HRS. 65. 119 HRS. Figure 2-39. Space Processing Shared Flows ..... Learning Curve: An 80 percent learning curve will be used to extrap ...

77

Soybean Rust Economic Assessment

The difficult economic circumstances with which almost the whole world had to contend, brought serious financial crisis in many countries. South Africa also had its own share of serious problems. Despite this situation, Transvaal Consolidated Land and Exploration Company, Limited, showed on increase in earnings of 24 per cent per share. The reason for this lies mainly in two areas. Firstly the company acquired the mining related business of Rand Mines, Limited. Included in the acquisition was a partfolio of shares mainly in the company's associated gold and uranium mining companies and additional shares in its listed coal mining subsidiaries. Secondly, the average gold price realised by producers in rand terms, was considerably higher than in the previous year. Consolidated profit attributable to members increased by 52 per cent to R82,6 million.

1983-12-01

78

Reenergizing Public Health Through Precaution

& International Markets Bottom of Browse By Subject You are here: Home / Featuring / Soybean Rust Featuring Print this page Print | E-mail this link E-mail | Bookmark & Share...

2011-10-01

79

Protein misfolding disorders and macroautophagy

The precautionary principle has provoked a spirited debate among environmentalists worldwide, but it is equally relevant to public health and shares much with primary prevention. Its central components...Full Text Available

2001-09-01

80

Problems of Water Use and Estimation of Water Right in North Han River Shared by North and South Korea (I) -Analysis of Diversion Impacts on Downstream Area by Imnam Dam

A large group of diseases, termed protein misfolding disorders, share the common feature of the accumulation of misfolded proteins. The possibility of a common mechanism underlying either the pathogenesis...Full Text Available

2011-04-01

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81

Primary lymphoma of the brain: MedlinePlus Medical Encyclopedia

Full Text Available

2011-04-01

82

Lens-induced glaucoma in the elderly

brain Printer-friendly version Email this page to a friend Share Primary lymphoma of the brain is cancer of the lymph cells that starts in the brain. Causes The cause of primary...

2011-10-13

83

In Defense of Change Processes

Lens-induced glaucoma comprises a number of different glaucomatous processes occurring in the elderly that share in common the role of the crystalline lens in the mechanism of increase in intraocular...Full Text Available

2009-01-01

84

GHG Inventories & Forecasts: National Inventories and Forecasts...

Nativist and constructivist approaches to the study of development share a common emphasis on characterizing beginning and end states in development. This focus has highlighted the question...Full Text Available

2008-01-01

85

Funding will push battery technology from Argonne Laboratory

of different transportation fuels (e.g., gasoline, diesel fuel, aviation gasoline, jet fuel, residual fuel oil). Subsequent calculations are performed to estimate the share...

2011-08-26

86

Epithelial cells derived from human embryonic stem cells display p16INK4A senescence, hypermotility, and differentiation properties shared by many P63+ somatic cell types

Publications Science Highlights Researcher Profiles Internship Funding to push battery technology from Argonne Laboratory to marketplace Bookmark and Share (Download...

2011-08-27

87

Dynamic Phenotypic Clustering in Noisy Ecosystems

Udgivelsesdato: 2009-Jun

2009-01-01

88

Cross-sectional survey of users of Internet depression communities

In natural ecosystems, hundreds of species typically share the same environment and are connected by a dense network of interactions such as predation or competition for resources. Much is known about...Full Text Available

2011-03-01

89

Choosing and Using a Plant DNA Barcode

BackgroundInternet-based depression communities provide a forum for individuals to communicate and share information and ideas. There has been little research into the health status...Full Text Available

90

Arc Habitat Suitability Index computer software

The main aim of DNA barcoding is to establish a shared community resource of DNA sequences that can be used for organismal identification and taxonomic clarification. This approach was successfully...Full Text Available

91

An Extended Kalman Filter for Use in a Shared Aperture ...

Sep 1, 2011 ... Publication Information. Bookmark and Share. Title: Arc Habitat Suitability Index computer software. Author: Juntti, Thomas M.; Rumble, Mark A. ...

92

Zebrafish: A Model System for the Study of Eye Genetics

... used to track a point source target ... A one sigma tracking error of .2 ... LOOKING INFRARED SYSTEMS, *KALMAN FILTERING, SIGNAL PROCESSING ...

1978-12-01

93

Use of Forward Genetics to Discover Novel Regulators of NF-?B

Over the last decade, the use of the zebrafish as a genetic model has moved beyond the proof-of-concept for the analysis of vertebrate embryonic development to demonstrated utility as a mainstream...Full Text Available

2008-01-01

94

Tissue Effect on Genetic Control of Transcript Isoform Variation

Forward and reverse genetic experiments have both played important roles in revealing critical aspects of mammalian signal transduction pathways in cell culture experiments. Only recently have we begun...Full Text Available

2010-06-01

95

Survival of Genetically Modified and Self-Cloned Strains of Commercial Baker's Yeast in Simulated Natural Environments: Environmental Risk Assessment

Current genome-wide association studies (GWAS) are moving towards the use of large cohorts of primary cell lines to study a disease of interest and to assign biological relevance to the genetic signals...Full Text Available

2009-08-01

96

Strategies for the production of genetically identical monkeys by embryo splitting

Although genetic engineering techniques for baker's yeast might improve the yeast's fermentation characteristics, the lack of scientific data on the survival of such strains in natural environments...Full Text Available

2005-11-01

97

Reproduction in three genetic lines of dairy cattle housed a total confinement system.

Genetically identical rhesus monkeys would have tremendous utility as models for the study of human disease and would be particularly valuable for vaccine trials and tissue transplantation studies where...Full Text Available

98

Radiation risks for medical applications

Dairy cattle of three genetic lines maintained year round in total confinement (either in loose housing or tie stall barn) were monitored for estrous cycle activity and reproductive performance. Only...Full Text Available

1981-10-01

99

RISK-XLR: A Microcomputer-Based Genetic Risk Program for X-Linked Recessive Traits

The achievements made in the field of radiation protection over the past 20 years are outlined. Risk analysis as applied to medicine is considered and genetic significant doses, genetic risks, somatic effective doses and somatic risks are discussed. (C.F.).

1980-05-31

100

Potential of plant genetic systems for monitoring and screening mutagens

A computer program, RISK-XLR, which calculates genetic risk for carrier status of a Mendelian X-linked recessive condition has been written for the Macintosh series of microcomputers. The program,...Full Text Available

1987-11-04

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101

Persistence of genetic variants of the arctic fox strain of Rabies virus in southern Ontario

Plants have too long been ignored as useful screening and monitoring systems of environmental mutagens. However, there are about a dozen reliable, some even unique, plant genetic systems that can increase...Full Text Available

1978-12-01

102

Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis

AbstractGenetic-variant analysis of rabies viruses provides the most sensitive epidemiologic tool for following the spread and persistence of these viruses in their wildlife hosts. Since...Full Text Available

2006-01-01

103

Heritability of Measures of Kidney Disease Among Zuni Indians: The Zuni Kidney Project

Auxin modulates diverse plant developmental pathways through direct transcriptional regulation and cooperative signaling with other plant hormones. Genetic and biochemical approaches have clarified...Full Text Available

2004-10-12

104

Genomic Evidence for the Evolution of Streptococcus equi: Host Restriction, Increased Virulence, and Genetic Exchange with Human Pathogens

BackgroundThe long-term goal of the GKDZI (Genetics of Kidney Disease in Zuni Indians) Study is to identify genes, environmental factors, and genetic-environmental...Full Text Available

2010-08-01

105

Genetic susceptibility to systemic lupus erythematosus in the genomic era

The continued evolution of bacterial pathogens has major implications for both human and animal disease, but the exchange of genetic material between host-restricted pathogens is rarely considered....Full Text Available

2009-03-01

106

Genetic relationship between anxiety- and fear -related behaviors in BXD recombinant inbred mice

Our understanding of the genetic basis of systemic lupus erythematosus (SLE) has been rapidly advanced using large-scale, case–control, candidate gene studies as well as genome-wide...Full Text Available

2010-12-01

107

Genetic predisposition for femoral neck stress fractures in military conscripts

Mood and anxiety disorders and rodent phenotypic measures modeling these disorders have a strong genetic component. Various assays are used to study the neurobiological basis of fear- and anxiety-related...Full Text Available

2009-03-01

108

Genetic evidence of illegal trade in protected whales links Japan with the US and South Korea

BackgroundStress fractures are a significant problem among athletes and soldiers and may result in devastating complications or even permanent handicap. Genetic factors may increase...Full Text Available

109

Genetic aspects of birth defects: new understandings of old problems

We report on genetic identification of ‘whale meat’ purchased in sushi restaurants in Los Angeles, CA (USA) in October 2009 and in Seoul, South Korea in June and September 2009. Phylogenetic...Full Text Available

2010-10-23

110

Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

Over the past two decades, combined advances in genetics, developmental biology and biochemistry have transformed the study of human birth defects. This review describes the importance of genome architecture,...Full Text Available

2007-07-01

111

Genetic Monitoring and Evaluation Program for Supplemented Populations of Salmon and Steelhead in the Snake River Basin, 1990-1991 Annual Report.

The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes that underlie these traits, the magnitude...Full Text Available

2008-12-16

112

Genetic Elucidation of Human Hyperosmia to Isovaleric Acid

This is the first report of research for an ongoing study to evaluate the genetic effects of using hatchery-reared fish to supplement natural populations of chinook salmon and steelhead in the Snake River Basin.

1991-08-01

113

Genetic Diversity Assessment of Rarely Cultivated Traditional Indica Rice (Oryza sativa L.) Varieties

The genetic basis of odorant-specific variations in human olfactory thresholds, and in particular of enhanced odorant sensitivity (hyperosmia), remains largely unknown. Olfactory receptor (OR) segregating...Full Text Available

2007-11-01

114

Energy metabolism of the untrained muscle of elite runners as observed by 31P magnetic resonance spectroscopy: evidence suggesting a genetic endowment for endurance exercise.

Random amplified polymorphic DNA fingerprinting was performed to assess the genetic diversity among rarely cultivated traditional indica rice (Oryza sativa ...Full Text Available

115

Effect of Feeding Cows Genetically Modified Maize on the Bacterial Community in the Bovine Rumen?

The purpose of this study was to investigate whether genetically determined properties of muscle metabolism contribute to the exceptional physical endurance of world-class distance runners. ATP, phosphocreatine,...Full Text Available

1988-12-01

116

Creating genetically modified pigs by using nuclear transfer

Rumen-cannulated cows (n = 4) were fed successively silage made from either conventional or genetically modified (GM) maize. Results revealed no effects of GM maize on the dynamics...Full Text Available

2007-12-01

117

Construction and Application of a Zebrafish Array CGH Platform

Nuclear transfer (NT) is a procedure by which genetically identical individuals can be created. The technology of pig somatic NT, including in vitro maturation of oocytes, isolation and treatment of...Full Text Available

118

Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease

The zebrafish is emerging as a prominent model system for studying the genetics of human development and disease. Genetic alterations that underlie each mutant model can exist in the form of...Full Text Available

2009-02-01

119

A Strong Case for Viral Genetic Factors in HIV Virulence

This study examined the genetic basis of hypertension and renal disease in Dahl SS/Mcwi (Dahl Salt-Sensitive) rats using a complete chromosome substitution panel of consomic rats in which each of the...Full Text Available

2008-09-01

120

A Cytogenetic Abnormality and Rare Coding Variants Identify ABCA13 as a Candidate Gene in Schizophrenia, Bipolar Disorder, and Depression

HIV infections show great variation in the rate of progression to disease, and the role of viral genetic factors in this variation had remained poorly characterized until recently. Now a series of four...Full Text Available

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121

Soil microbial toxicity of eight polycyclic aromatic compounds: effects on nitrification, the genetic diversity of bacteria, and the total number of protozoans.

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations, with heritability estimates of ∼80% indicating a substantial genetic component. Population genetics...Full Text Available

2009-12-11

122

Primer for the Potato Specific Internal Control DNA and Screening Method for the Genetically Modified Potatoes by Competitive Duplex-PCR

Udgivelsesdato: 2002-Aug

2002-01-01

123

Genetic Applications in Avian Conservation

Full Text Available

2002-12-01

124

Genetic and somatic risks in X-ray diagnosis

... structure along an elevational gradient in Hawaiian honeycreepers reveals contrasting evolutionary responses to avian malaria. BMC Evolutionary Biology 8: ... ...

125

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI): final 5-year results suggest long-term safety and efficacy

Based on a literature study an actual summary of the risk-utility problems in X-ray diagnosis is outlined due to the Recommendations of the International Commission for Radiation Protection (ICRP publication 26/1977). Papers demonstrating quantitative assessment of the somatic and genetical risk in X-ray examination are preferably cited and evaluated. It is concluded that the somatic and genetical risk is low in diagnostic ratiology. However, it must not be neglected and has always to be compared to the utility of an examination as well as to other risks of the examination. (author).

1982-01-01

126

British Library Electronic Table of Contents (United Kingdom)

Background Limited data is available for investigating the long-term safety and effects of intracoronary progenitor cell therapy in patients with acute myocardial infarction (AMI). Objective To assess the clinical course, NT-proBNP and MRI data as objective markers of cardiac function of the TOPCARE-AMI patients at 5-year follow-up. Design The TOPCARE-AMI trial was the first randomized study investigating the effects of intracoronary infusion of circulating (CPC) or bone marrow-derived progenitor cells (BMC) in 59 patients with successfully reperfused AMI. Results Five-year follow-up data were completed in 55 patients, 3 patients were lost to follow-up. None of the patients showed any signs of intramyocardial calcification or tumors at 5?years. One patient died during the initial hospitali...

2011-01-01

127

Malignant solitary fibrous tumor of the thyroid gland: Report of a case and review of the literature

British Library Electronic Table of Contents (United Kingdom)

Abstract Solitary fibrous tumors of the thyroid gland (T-SFT) are rarely described, with only 21 cases being reported in the English literatures, all showing benign clinical characteristics. We herein present a 76-year-old woman presenting with a 3-month history of rapidly enlarging neck masses and the CT showed masses with partial calcification in the right thyroid lobe. We performed right hemithyroidectomy and isthmectomy with negative margin under general anesthesia. Histologically, the masses consisted of pleomorphic spindle cells with high mitoses and collagen bands. Immunohistochemically, the tumor cells showed positive reactions for CD34, vimentin and bcl-2, then a diagnosis of malignant solitary fibrous tumor of the right thyroid was made. Six months postoperatively, the CT showed ...

2011-01-01

128

Characteristic features of intracranial meningiomas on magnetic resonance tomography

CT findings of malignant lymphoma of the anterior mediastinum. Differentiation from invasive thymoma

Twenty-three patients with intracranial meningiomas were examined by means of magnetic resonance tomography (MRT). In 13 patients the paramagnetic contrast medium gadolinium DTPA was used. Meningiomas show only slight changes in signal intensity compared with brain in the spin-echo mode, the greatest contrast being found on photon density images (TR 1600 ms, TE 35 ms). In T1 images more than 50% of the patients showed a low signal margin between tumour and brain. Hyperostosis of the calvarium is easily recognised, but MRT is unreliable for showing tumour calcification. After intravenous injection of gadolinium DTPA, there was marked homogeneous uptake in the meningiomas. These signs are useful for the diagnosis of a meningioma by MRT. (orig.).

129

Translational bioinformatics and healthcare informatics: computational and ethical challenges.

CT findings were compared retrospectively between 9 cases with malignant lymphoma of the anterior mediastinum and 8 cases with invasive thymoma. CT findings of malignant lymphoma were as follows: (1) The majority of the tumors were bilateral and extended beyond the anterior mediastinum to the other mediastinum compartments. (2) Their margin was either smooth or lobulated. (3) Their density was either homogeneous or heterogeneous. In the case with heterogeneous density, ring, triangle and/or band-like low density areas, just like interspace of fused lymph nodes, were demonstrated. Calcification or cysts could not be shown. (4) Patent inherent vessels without deviation were occasionally demonstrated running through the tumors. (5) The tumors faced and contacted widely to anterior chest wall and often pressed the lung laterally at the anterior parietomediastinal pleural reflection. (6) Pleural implants were not demonstrated. (author).

1989-04-01

130

Computed Tomography in the study of pulmonary tuberculosis

Exponentially growing biological and bioinformatics data sets present a challenge and an opportunity for researchers to contribute to the understanding of the genetic basis of phenotypes. Due to breakthroughs in microarray technology, it is possible to simultaneously monitor the expressions of thousands of genes, and it is imperative that researchers have access to the clinical data to understand the genetics and proteomics of the diseased tissue. This technology could be a landmark in personalized medicine, which will provide storage for clinical and genetic data in electronic health records (EHRs). In this paper, we explore the computational and ethical challenges that emanate from the intersection of bioinformatics and healthcare informatics research. We describe the current situation of the EHR and its capabilities to store clinical and genetic data and then discuss the Genetic ...

2009-09-16

131

A comparison of cathode ray tube (CRT) and computed radiography (CR) diagnosis in mammography

The authors carried out a retrospective study on 4 years' work on a series of patients with proved active tuberculosis examined in the Departments of Bronchopneumology and Infectious Disease of the Arezzo Civil Hospital. The population was heterogenerous from the immunologic viewpoint. This paper compared the effectiveness of Computed Tomography (CT) with that of conventional chest radiography (CR) in the diagnosis and prognosis of tuberculosis. All patients underwent chest CR in double projection and conventional CT studies of the chest; 16 patients were also submitted to high resolution CT (HRCT). Consolidation was the most frequent parenchymal lesion in immunocompetent patients; it was often associated with cavitation, with no clear topographic prevalence in the upper lobes. Pleural effusion, as the only sign of disease and with empyema features, was found in 10 immunocompetent patients. No predominant pattern was found in the other two groups, even though intrathoracic adenopathies ...

1997-01-01

132

Forest genetics: research and application in Indian forestry

Quantitative evaluation of CRT and CR observations in indentification of malignancy using phantom and clinical data. A breast phantom and a total of 40 patients were imaged by Fuji computed radiography (FCR). The images were interpreted twice by six radiologists both on CR film (2510 x 2000 pixels x 10 bits, 0.1 mm spatial resolution) and on a CRT monitor (1568 x 1152 pixels x 10 bits, 0.1 mm pixel size with double expansion) with image processing parameters of a toutine (RN 1.0, RE 0.2), for a calcification (RN 9.0, RE 4.0) and for a mass (RN 7.0, RE 2.0). The forty clinical cases included breast diseases with calcifications, masses, and normal breasts. Two-tailed t-test was performed to analyze interpretation of simulated microcalcifications and masses in the phantom. The receiver operating characteristic (ROC) analysis was performed to evaluate clinical cases. In all interpretation studies using both breast phantom and clinical cases, there ...

1999-11-01

133

Assessing the mediating role of online social capital between social support and instant messaging usage

Sufficient genetic diversity exists in Indian tree species to give large genetic gains. Improvement potential, using wild gene resources for selection and breeding is vast as there are over 244 genera and 400 forest tree species in India. Of these over 30 species and 22 genera are of outstanding forestry value. Selective genetic-variation can be lifted from wild populations, multiplied vegetatively or by seed, and planted with controlled germplasm sources. Among the Indian species no less than 74 reproduce by cutting, 11 by layers, 9 by grafting and buding and 104 by root suckers. More than 161 species coppice vigorously. Afforestation techniques of over 170 species have been worked out. Tree genetic approach of survey of natural variability, quick evaluation, selection, conservation multiplication and planting superior variability directly in the field can give immediate genetic ...

1981-04-01

134

British Library Electronic Table of Contents (United Kingdom)

This study validates a research model that examines usage of instant messaging (IM) from the aspect of online social support. Drawing on the social capital theory, this study postulates that IM usage is indirectly affected by social support via the mediation of the following six dimensions of social capital: commitment, reciprocity, shared codes and language, shared narratives, centrality, and network ties. The model tests data obtained from business organizations in Taiwan, and the results suggest that the indirect influence of social support on IM usage through shared codes and language is significant, and the indirect influence of social support on IM usage through centrality is also significant. Managerial implications and limitations of the empirical findings are provided.

2011-01-01

135

Genetic variability, heritability and genetic advance for seedling traits in sorghum genotypes

Exons, Introns and Talking Genes: The Sience Behind the Human Genome Project

Analysis of data on seedling traits from 20 diverse genotypes revealed significant differences fro most of the seedling traits. Significant estimates of broad-sense heritability were observed for VI, ERI, FRTW, DRTW and R/S ratio. Genetic advance was maximum for VI,ERI and E%. The correlation of VI with ERI and R/S ratio was negative and significant, whereas it was positive and significant with E%, FSHW and DSHW. Characterization of the sorghum genotypes according to Anderson's Metro glyph Statistics revealed five different groups for seedling trails. (authors)

1999-01-01

136

Widespread duplications in the genomes of laboratory stocks of Dictyostelium discoideum

This book presents in simple terms the basis of molecular genetics and how it is used to obtain an understanding of the human genome. The author's central focus is the transistion of genetics from statistics to experimental manipulations, and he offers analogies that help readers visualize the genome, thereby avoiding conventional scientific presentations. He illustrates how genetics is used in scientific laboratories, in courtrooms, and in hospitals. Little is presented about the complex social and ethical issues raised by the Human Genome project.

1993-01-01

137

Two-phase application of multi-objective genetic algorithms in green building design

BackgroundDuplications of stretches of the genome are an important source of individual genetic variation, but their unrecognized presence in laboratory organisms would be a confounding...Full Text Available

2008-01-01

138

The evaluation of risks from radiation

The application of multi-objective genetic algorithms for green building design in two phases were presented in order to better help designers in the decision-making process. The purpose is to minimize two conflicting criteria: the life-cycle cost and the life-cycle environmental impact. Environmental impact criteria examined include energy and non-energy natural resources, global warming, and acidification. Variables focus on building envelope-related parameters. The application of multi-objective genetic algorithms is divided into two phases. The first phase intends to help designers in understanding the trade-off relationship between the two conflicting criteria. The second phase intends to refine the performance region that is of the designer's interest. The results after the two-phase application of the multi objective genetic algorithm were then presented. 13 refs., 4 tabs., 3 figs.

2005-07-01

139

The burden of genetically determined eye disease.

German translation of the publication 'The evaluation of risks from radiation' published in 1965 by the International Commission on Radiological Protection. In a survey, genetic and somatic risks from radiation are presented and explained. (HP).

1977-01-01

140

The biological aspects and behaviour of Heliothis virescens Fabricius adults from irradiated diapausal pupae

We determined the underlying aetiology of blindness for the registered blind population of the Province of Newfoundland and Labrador. In both 1981 and 1984 single-gene disorders accounted for 30% of...Full Text Available

1986-09-01

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141

Telomeres and telomerase in cancer

... bollworm fertility gamma radiation genetic radiation effects life span mating

1974-07-22

142

Spatial Epidemiology: Current Approaches and Future Challenges

Myriad genetic and epigenetic alterations are required to drive normal cells toward malignant transformation. These somatic events commandeer many signaling pathways that cooperate to endow aspiring...Full Text Available

2010-01-01

143

Salicylate Metabolism in Twins

Spatial epidemiology is the description and analysis of geographic variations in disease with respect to demographic, environmental, behavioral, socioeconomic, genetic, and infectious risk factors....Full Text Available

2004-06-01

144

Role of the 5HT3 Receptor in Alcohol Drinking and ...

To evaluate the contribution of genetic influences on the individual variation in plateau serum salicylate levels, salicylate metabolism was studied in seven pairs of identical and six pairs of fraternal...Full Text Available

1977-07-01

145

Retinoids for Treatment of Retinal Diseases

... Proc Natl Acad Sci USA 97:11032-7 27. Duman RS 2002 Genetics of childhood disorders: XXXIX. Stem cell research, part 3: ...

2005-09-01

146

Principles of antibody therapy.

Knowledge about retinal photoreceptor signal transduction and the visual cycle required for normal eyesight has expanded exponentially over the past decade. Substantial progress in human genetics...Full Text Available

2010-06-01

147

Pharmacogenetics of aspirin resistance: a comprehensive systematic review

The success of monoclonal antibodies in clinical practice is dependent on good design. Finding a suitable target is the most important part as other properties of the antibody can be altered by genetic...Full Text Available

1992-12-05

148

Myxoviruses Monitoring in Seals Populations

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECTA genetic basis for aspirin resistance has been postulated to exist.The...Full Text Available

2008-08-01

149

POSTNOTE

Wastenet

the environment, with the 2006 release of a GM pink bollworm moth (a pest of cotton), ...Use of Genetically Engineered Fruit Fly and Pink Bollworm in APHIS Plant Pest Control Programs 6 Gould,

150

International Science & Technology Center (ISTC)

Comparative Molecular Genetic Monitoring of Myxoviruses Circulating in Populations of Seals Phoca Caspia and Phoca Sibirica in Northern Caspian Region and Lake Baikal

151

Mutations in RNA Binding Protein Gene Cause Familial Dilated Cardiomyopathy

Molecular based assessment of genetic diversity within Barbary fig (Opuntia ficus indica (L.) Mill.) in Tunisia

ObjectivesWe sought to identify a novel gene for dilated cardiomyopathy (DCM).BackgroundDCM is a heritable, genetically...Full Text Available

2009-09-01

152

British Library Electronic Table of Contents (United Kingdom)

In this work, we report for the first time on the analysis of genetic diversity within a set of 36 Tunisian Opuntia ficus indica (L.) Mill. ecotypes using RAPD markers.Random decamer primers were screened to assess their ability to detect polymorphisms in this plant crop. Thirty-nine RAPD markers were revealed and used to survey the genetic diversity at the DNA level and to establish relationships.Consequently, considerable genetic diversity was detected and the UPGMA analysis permitted the discrimination of all the genotypes and enabled their sorting into thirteen groups. The accession `R Sbiba inerme' was significantly divergent from all tested genotypes. In addition, as shown by the clustering the tested genotypes did not significantly diverge, though originating from different localiti...

2007-01-01

153

Microarray-based gene expression profiles of silkworm brains

Loss of genetic connectivity and diversity in urban microreserves in a southern California endemic Jerusalem cricket (Orthoptera: Stenopelmatidae: Stenopelmatus n. sp. ?santa monica??)

BackgroundMolecular genetic studies of Bombyx mori have led to profound advances in our understanding of the regulation of development. Bombyx mori brain,...Full Text Available

154

British Library Electronic Table of Contents (United Kingdom)

Microreserves may be useful in protecting native arthropod diversity in urbanized landscapes. However, species that do not disperse through the urban matrix may eventually be lost from these fragments. Population extinctions may be precipitated by an increase in genetic differentiation among fragments and loss of genetic diversity within fragments, and these effects should become stronger with time. We analyzed population genetic structure in the dispersal limited Jerusalem cricket Stenopelmatus n. sp. ?santa monica?? in the Santa Monica Mountains and Simi Hills north of Los Angeles, California (CA), to determine the impacts of fragmentation over the past 70 years. MtDNA divergence was greater among urban fragments than within contiguous habitat and was positively correlated with fragment ...

2009-01-01

155

Imaging immune response in vivo

Genomics of human longevity

PurposeClinical trials have commenced to evaluate the feasibility of targeting malignant gliomas with genetically engineered cytolytic T-cells (CTLs) delivered directly...Full Text Available

2008-06-15

156

Genetic structure of gilthead seabream, Sparus aurata, in the Central Mediterranean Sea

In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences...Full Text Available

2011-01-12

157

British Library Electronic Table of Contents (United Kingdom)

The gilthead seabream, Sparus aurata, represents an important economic resource for Mediterranean aquaculture. In spite of its wide geographic distribution and economic importance, only recently studies have been carried out on the genetic composition of natural populations, which have revealed a picture of a heterogeneous degree of genetic differentiation among S. aurata populations. In this study an allozyme analysis of samples from six different collecting sites along the Italian and Croatian coasts was carried out, covering an area in the Central Mediterranean sea that has yet to be investigated through gene-enzyme systems. Data on 26 gene loci, 10 of which are polymorphic, indicate a slight but significant genetic structure (FST = 0.0167) of the species. A hierarchical analysis of pop...

2006-01-01

158

Genetic Architecture Underlying Variation in Extent and Remodeling of the Collateral Circulation

GENETIC STUDIES OF PIGMENTATION IN ...

RationaleCollaterals are arteriole-to-arteriole anastomoses that connect adjacent arterial trees. They lessen ischemic tissue injury by serving as endogenous bypass...Full Text Available

2010-08-20

159

Evidence for Epigenetic Interactions for Loci on Mouse Chromosome 1 Regulating Open Field Activity

... Strains Smith and -aybush were both grown in broth containing from 0.1 to 50 pg/ml of acriflavin, acridine orange, or proflavin. ...

1966-05-01

160

British Library Electronic Table of Contents (United Kingdom)

The expression of motor activity levels in response to novel situations is under complex genetic and environmental control. Several genetic loci have been implicated in the regulation of this behavioral phenotype, but their relationship to epigenetic and epistatic interactions is relatively unknown. Here, we report on a quantitative trait locus (QTL) on mouse chromosome 1 for novelty-induced motor activity in the open field, using chromosome substitution strains derived from a high active host strain (C57BL/6J) and a low active donor strain (A/J). The QTL for open field (horizontal distance moved) peaked at the location of Kcnj9, however, QTL detection was initially masked by an interplay of both grandparent genetic origin and genetic co-factors influencing behavior on chromosome 1. Our fi...

2009-01-01

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161

Estimation of Genetic Parameters for Growth-Related Traits in 9-month Old of Two Korean Abalone Subspecies, Haliotis discus hannai and H. discus discus, by Using Multiple Traits of Animal Model

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model

Full Text Available

2009-12-01

162

Distinct sensory representations of wind and near-field sound in the Drosophila brain

BackgroundMutations that disrupt the conversion of prelamin A to mature lamin A cause the rare genetic disorder Hutchinson-Gilford progeria syndrome and a group of laminopathies....Full Text Available

163

Current Projects - Human Nutrition Research Center on Aging ...

Behavioral responses to wind are thought to play a critical role in controlling the dispersal and population genetics of wild Drosophila species1,Full Text Available

2009-03-12

164

diet and genetic obesity metabolic defects and inflammation. To determine the role of adipocyte death in promoting adipose tissue inflammation and insulin resistance in animal...

2011-08-31

165

Culture and cooperation

Consumer attitudes and decision-making with regard to genetically engineered food products: A review of the literature and a presentation of models for future research

Does the cultural background influence the success with which genetically unrelated individuals cooperate in social dilemma situations? In this paper, we provide an answer by analysing the data of Full Text Available

2010-09-12

166

Comparing Genomes within the Species Mycobacterium tuberculosis

Executive summary 1. Few studies have to date explained consumer attitudes and purchase decisions with regard to genetically engineered food products. However, the increased marketing of genetically engineered food products and the considerable concern that consumers seem to express with regard to the technology call for the development of a theoretical basis for research into these issues. 2. The aim of the paper is to present three models which we have developed to explain consumer attitudes, buying behaviour and attitude change with regard to genetically engineered food products. All three models build on established consumer behaviour theory and on existing and comparable research in the field. 3. Consumer attitudes toward genetic engineering in food products are explained in an attitude model that builds on Fishbein's multiattribute attitude model. The model deviates from Fishbein's model in a ...

1998-01-01

167

Combining Genetics and Population History in the Study of Ethnic Diversity in the People's Republic of China

The study of genetic variability within natural populations of pathogens may provide insight into their evolution and pathogenesis. We used a Mycobacterium tuberculosis high-density...Full Text Available

2001-04-01

168

Can microRNAs act as biomarkers of aging?

... some Central Asian populations (Zerjal et al. 2002). Haplogroup W has a similar Middle Eastern origin, and again ... ...

169

Allozyme Divergence in Two Syntopic Liolaemus of the Liolaemus monticola Group (Squamata: Tropiduridae)

Aging can be defined as a progressive decline in physiological efficiency regulated by an extremely complex multifactorial process. The genetic makeup of an individual appears to dictate this rate...Full Text Available

170

AEC syndrome - Genetics Home Reference

... shareware for population genetic analysis. Molecular Biology and Biotecnology Centre, Univ. of Alberta, Canada. enlarge figure Fig. ... ...

171

Understanding how out of pocket expenses, treatment value and patient characteristics influence treatment choices

What genes are related to AEC syndrome? AEC syndrome is caused by mutations in the TP63 gene. This gene provides instructions for making a protein known as p63, which plays an...

2011-10-15

172

Transvaal Consolidated Land and Exploration Company, Limited. Chairman's statement for the year ended 30th September, 1983

PURPOSECost-sharing, intended to control the “over-use” of healthcare resources, may also reduce utilization of necessary services. The influence...Full Text Available

2010-01-01

173

Temporal and Tissue-Specific Patterns of Pon3 Expression in Mouse: In situ Hybridization Analysis

The difficult economic circumstances with which almost the whole world had to contend, brought serious financial crisis in many countries. South Africa also had its own share of serious problems. Despite this situation, Transvaal Consolidated Land and Exploration Company, Limited, showed on increase in earnings of 24 per cent per share. The reason for this lies mainly in two areas. Firstly the company acquired the mining related business of Rand Mines, Limited. Included in the acquisition was a partfolio of shares mainly in the company's associated gold and uranium mining companies and additional shares in its listed coal mining subsidiaries. Secondly, the average gold price realised by producers in rand terms, was considerably higher than in the previous year. Consolidated profit attributable to members increased by 52 per cent to R82,6 million.

1983-12-01

174

Shared versus specialized glycinergic spinal interneurons in axial motor circuits of larval zebrafish

PON3 is a member of the paraoxonase gene family that includes PON1 and PON2. For example, PON3 and PON1 share...Full Text Available

2010-01-01

175

Quantifiable Biomarkers of Normal Aging in the Japanese Medaka Fish (Oryzias latipes)

The neuronal networks in spinal cord can produce a diverse array of motor behaviors. In aquatic vertebrates such as fishes and tadpoles, these include escape behaviors, swimming across a range...Full Text Available

2008-11-26

176

Prospects for Collective Security in the Gulf Following the Kuwait Crisis.

BackgroundSmall laboratory fish share many anatomical and histological characteristics with other vertebrates, yet can be maintained in large numbers at low cost for lifetime studies....Full Text Available

177

Network information security in a phase III Integrated Academic Information Management System (IAIMS).

The history of the Arabian Gulf region shows a lot of commonality in the six states which form the Gulf Cooperation Council (GCC). Their shared heritage ranges from common colonial masters to common religion and language. Because of their oil wealth and, ...

1991-01-01

178

Natural gas in the Federal Republic of Germany. Aardgas in West Duitsland; Harde concurrentie in een liberale markt

The developing Integrated Academic Information System (IAIMS) at Columbia-Presbyterian Medical Center provides data sharing links between two separate corporate entities, namely Columbia University...Full Text Available

1992-01-01

179

Meet the NASA Scientists and Engineers Andrea ... - Aura - NASA

Petroleum is the unchallenged energy market leader in West Germany,having a share of 42%; natural gas accounts for 16-17%. West Germany imports 29% of its natural gas from the Soviet Union, 28% from the Netherlands, 14% from Norway, and 1% from Denmark. In West Germany many-branched natural gas distribution system is operated, equipped with a.o. 21 installations for underground storage which results in a great flexibility of the system. Because of the preferential treatment given to the use of coal as fuel for power plants the share of natural gas has decreased to the present 6% in the last ten years. In the indutrial sector the share is 18%. Strict air pollution abatement measures ('TA-Luft') favour the use of natural gas. However, duty has been levied on the use of natural gas per January 1st, 1989. For space heating of houses and commercial buildings the share of natural gas is 27%. ...

1989-10-01

180

Investigation of Dyslexia and SLI Risk Variants in Reading- and Language-Impaired Subjects

Equipped with terahertz sensors, the Aura mission will see far more ... We introduce you to a few amazing individuals, all sharing the dubious title of rocket scientist . And a ..... similar thing happens with incoming light. Astronomers call it the ...

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181

Image Engine: an object-oriented multimedia database for storing, retrieving and sharing medical images and text.

Dyslexia (or reading disability) and specific language impairment (or SLI) are common childhood disorders that show considerable co-morbidity and diagnostic overlaps and have been suggested to share...Full Text Available

2011-01-01

182

Home | United States Virtual Presence Post Maldives

This paper describes Image Engine, an object-oriented, microcomputer-based, multimedia database designed to facilitate the storage and retrieval of digitized biomedical still images, video, and text...Full Text Available

1993-01-01

183

Design and Implementation of an Open Source Indexing Solution for a Large Set of Radiological Reports and Images

efforts to work with other countries to solve shared problems. U.S. Condemns Alleged WikiLeaks Disclosures November 29, 2010: President Obama and Secretary of State Hillary Rodham...

2011-09-15

184

Decentralized Data Sharing of Tissue Microarrays for Investigative Research in Oncology

This paper hopes to share the insights we experienced during designing, building, and running an indexing solution for a large set of radiological reports and images in a production environment for...Full Text Available

2007-11-01

185

Cancer Risk in Type 2 Diabetes Mellitus: Metabolic Links and Therapeutic Considerations

Tissue microarray technology (TMA) is a relatively new approach for efficiently and economically assessing protein and gene expression across large ensembles of tissue specimens. Tissue microarray technology...Full Text Available

186

Bipolar and ADHD Comorbidity: Both Artifact and Outgrowth of Shared Mechanisms

Type 2 diabetes mellitus (DM2) is increasing in incidence, creating worldwide public health concerns and impacting morbidity and mortality rates. An increasing number of studies have demonstrated shared...Full Text Available

2011-01-01

187

Analysis of the Pharmacokinetic Interaction between Cephalexin and Quinapril by a Nonlinear Mixed-Effect Model

Published rates of comorbidity between pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD) have been higher than would be expected if they were independent conditions,...Full Text Available

2010-12-01

188

Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts

Oligopeptidic drugs such as β-lactams and angiotensin-converting enzyme inhibitors share the same carriers in humans and animals, which results in possible pharmacokinetic interactions. To model...Full Text Available

1998-06-01

189

A gene expression signature shared by human mature oocytes and embryonic stem cells

Amyloid proteins constitute a chemically heterogeneous group of proteins, which share some biophysical and biological characteristics, the principal of which are the high propensity to acquire an incorrect...Full Text Available

190

32 CFR 813.4 - Combat camera operations.

BackgroundThe first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have...Full Text Available

191

Fear, panic and prosperity consciousness: developing resilience as the paradigm shifts

...COMCAM forces document Air Force and air component activities...supported unified command or joint task force commander, through the...Force COMCAM forces in a joint environment. If an...share of Unified Command headquarters COMCAM and visual...

2010-07-01

192

British Library Electronic Table of Contents (United Kingdom)

Purpose - The article shares insights from a program that was developed to address burnout, compassion fatigue and vicarious trauma. The program works from the premise that people and organizations thrive when they have shared values and common understandings. Design/methodology/approach - The approach draws together reflection at the organizational and person levels. Connecting business ethics and organizational analysis, improving understanding of the body's energy as well as inter-cultural understanding are all achievable while adopting the resilience development methods. Findings - The article concludes that reflective practice through the tools used on the program enhances understanding of the challenges faced by organizations and the individuals involved. It provides creative routes ...

2009-01-01

193

Quantitative genetic activity graphical profiles for use in chemical evaluation

Optimal selection of capacitors for radial distribution systems using a genetic algorithm

A graphic approach, terms a Genetic Activity Profile (GAP), was developed to display a matrix of data on the genetic and related effects of selected chemical agents. The profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical. Either the lowest effective dose or highest ineffective dose is recorded for each agent and bioassay. Up to 200 different test systems are represented across the GAP. Bioassay systems are organized according to the phylogeny of the test organisms and the end points of genetic activity. The methodology for producing and evaluating genetic activity profile was developed in collaboration with the International Agency for Research on Cancer (IARC). Data on individual chemicals were compiles by IARC and by the US Environmental Protection Agency (EPA). Data are available on 343 compounds selected from volumes 1-53 of the IARC ...

1990-06-27

194

Nucleotide sequence and genetic analysis of a 13.1-kilobase-pair Pseudomonas denitrificans DNA fragment containing five cob genes and identification of structural genes encoding Cob(I)alamin adenosyltransferase, cobyric acid synthase, and bifunctional cobinamide kinase-cobinamide phosphate guanylyltransferase.

In this paper, a new design methodology for determining the size, location, type and number of capacitors to be placed on a radial distribution system is presented. The objective is to minimize the peak power losses and the energy losses in the distribution system considering the capacitor cost. A sensitivity analysis based method is used to select the candidate locations for the capacitors. A new optimization method using a Genetic Algorithm is proposed to determine the optimal selection of capacitors. Test results have been presented along with the discussion of the algorithm.

1994-08-01

195

Mobilization of the genetically engineered plasmid pHSV106 from Escherichia coli HB101(pHSV106) to Enterobacter cloacae in drinking water.

A 13.1-kb DNA fragment carrying Pseudomonas denitrificans cob genes has been sequenced. The nucleotide sequence and genetic analysis revealed that this fragment contained five different cob genes named...Full Text Available

1991-10-01

196

Liposome technology. Volume II: Incorporation of drugs, proteins and genetic material

We have used triparental matings to demonstrate transfer (mobilization) of the nonconjugative genetically engineered plasmid pHSV106, which contains the thymidine kinase gene of herpes simplex virus...Full Text Available

1991-01-01

197

Invasiveness and persistence of Salmonella enteritidis, Salmonella typhimurium, and a genetically defined S. enteritidis aroA strain in young chickens.

These three volumes cover liposome technology in pharmacology and medicine. Contributors emphasize methodology used in their own laboratories, and include a brief introduction, coverage of relevant literature, applications and critical evaluations for the methods they describe. Volume II presents procedures for the entrapment of a number of drugs, including genetic material, into selected types of liposomes.

1984-01-01

198

Genetics and biochemistry of Clostridium relevant to development of fermentation processes

Newly hatched chicks were dosed orally with a Salmonella typhimurium wild-type strain, an S. enteritidis wild-type strain, and a genetically defined S. enteritidis aroA vaccine candidate, strain CVL30....Full Text Available

1994-11-01

199

Genetic and somatic effects in animals maintained on tritiated water

It is the purpose of this review to draw together the recent research adding to our understanding of the molecular nature of Clostridia. The thrust here is to emphasize those research advances in biochemistry and genetics that bear upon future development of fermentation processes employing the Clostridia. 222 refs., 10 figs., 5 tabs.

1984-01-01

200

Generalized genetic code. A note on order-isomorphism/order-equivalence relations

The possible genetic (dominant lethal mutations (DLM) and cytogenetic changes in the regenerating liver) and somatic (hematopoietic stem cell changes, growth and nonspecific life time shortening) effects in mice maintained on tritiated water (HTO) over two generations was investigated. Results to date are summarized. (ACR)

1981-01-01

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201

Estimation of organ dose during radiological and computer tomographic examinations with calculations of the somatically significant doses

Constructive and combinatorial relationships between order-isomorphisms and order-equivalence classes within the generalized genetic code are presented, not only for the biologically relevant groups of order 4, but also for finite groups of arbitrary order. The main result is the derivation of the number (and types) or order-equivalence classes for a group of order n. Finally, an extension of this work to all biologically admissible alternative codes is discussed.

1982-01-01

202

Estimation of organ dose during radiological and computer tomographic examinations with calculations of the somatically significant doses

The risks from radiation exposure during radiological diagnosis has usually been estimated in relation to genetic changes. Relevant information has been expressed as the genetically significant dose. In this paper we attempt to produce an analogous measure for evaluating the somatic risk in the form of a somatically significant dose index for radiological and CT examinations. It is shown that, for both types of examination, the two risk factors may be entirely different.

1980-10-01

203

Biological effects and health risks following to the exposition to ionizing radiation

The risks from radiation exposure during radiological diagnosis has usually been estimated in relation to genetic changes. Relevant information has been expressed as the genetically significant dose. In this paper we attempt to produce an analogous measure for evaluating the somatic risk in the form of a somatically significant dose index for radiological and CT examinations. It is shown that, for both types of examination, the two risk factors may be entirely different. (orig.).

1980-01-01

204

A Genetic Screen for Ribosomal DNA Silencing Defects Identifies Multiple DNA Replication and Chromatin-Modulating Factors

Late somatic and genetic radiation effects are imperfectly understood, particularly in the human species. However the available information is sufficient to draw reasonably precise risk estimates in man for many types of damage by means of scientifically justifiable procedures and with the necessary caution. This overall absolute risk of major somatic and genetic damage may be set at around 10"-"4/rad of chronic whole-body doses.

1976-01-01

205

Study of the crystallographic architecture of corals at the nanoscale by scanning transmission X-ray microscopy and transmission electron microscopy.

Transcriptional silencing in Saccharomyces cerevisiae occurs at several genetic loci, including the ribosomal DNA (rDNA). Silencing at telomeres (telomere position effect [TPE])...Full Text Available

1999-04-01

206

Single exposure energy subtraction chest radiography in the diagnosis of pulmonary cancer

We have investigated the nanotexture and crystallographic orientation of aragonite in a coral skeleton using synchrotron-based scanning transmission X-ray microscopy (STXM) and transmission electron microscopy (TEM). Polarization-dependent STXM imaging at 40-nm spatial resolution was used to obtain an orientation map of the c-axis of aragonite on a focused ion beam milled ultrathin section of a Porites coral. This imaging showed that one of the basic units of coral skeletons, referred to as the center of calcification (COC), consists of a cluster of 100-nm aragonite globules crystallographically aligned over several micrometers with a fan-like distribution and with the properties of single crystals at the mesoscale. The remainder of the skeleton consists of aragonite single-crystal fibers in crystallographic continuity with the nanoglobules comprising the COC. Our observation provides information on the nm-scale processes that led to biomineral formation in this ...

2011-05-05

207

Single exposure energy subtraction chest radiography in the diagnosis of pulmonary cancer

A single exposure energy subtraction technique with a metal filter and an imaging plate for the Fuji Computed Radiography (FCR) system was developed for dual-energy subtraction radiography (DES) of the chest. By the use of this technique, 206 patients with suspected lung cancer were scanned in the clinical settings. The subtracted images in 200 patients, excluding six with poor image quality, were examined. Soft-tissue images (bone cancelled images) were useful in visualizing abnormality of the airway and nodules lying under the ribs; and bone images (soft-tissue cancelled images) in detecting rib metastases and the presence or absence of calcification in nodules. Additional information was acquired in 21 % (42/200). A single exposure is capable of neglecting motion artifacts. In addition, this technique may be of value in DES, which is considered to be one of the routine examinations, in view of low exposure doses. The need of conventional roentgenograph, in ...

1987-03-01

208

Ganglioneuromas in childhood: MRI and CT characteristics

A single exposure energy subtraction technique with a metal filter and an imaging plate for the Fuji Computed Radiography (FCR) system was developed for dual-energy subtraction radiography (DES) of the chest. By the use of this technique, 206 patients with suspected lung cancer were scanned in the clinical settings. The subtracted images in 200 patients, excluding six with poor image quality, were examined. Soft-tissue images (bone cancelled images) were useful in visualizing abnormality of the airway and nodules lying under the ribs; and bone images (soft-tissue cancelled images) in detecting rib metastases and the presence or absence of calcification in nodules. Additional information was acquired in 21 % (42/200). A single exposure is capable of neglecting motion artifacts. In addition, this technique may be of value in DES, which is considered to be one of the routine examinations, in view of low exposure doses. The need of conventional roentgenograph, in ...

1987-01-01

209

A study on brain CT of neurological endemic cretinism

Purpose: The aim of this study was to demonstrate the typical appearance of ganglioneuromas in computer-assisted tomography (CT), and magnetic resonance imaging (MRI). Material and methods: Retrospective analysis of diagnostic imaging (9 CT, 6 MRI) in 9 children aged 3 to 15 years with the histological diagnosis of ganglioneuroma. Results: The tomographies showed large (max. 13.4 cm in diameter) round or oval tumors with sharp delineation. The sites of the tumors were the retroperitoneum (5), the mediastinum (3), and the adrenal gland (1). Intraspinal tumor involvement occurred in 4 cases. On comparing CT with MRI, MRI was more accurate in defining the intraspinal involvement. The ganglioneuromas were of hypodense appearance in the native CT scan and showed moderate enhancement upon administration of contrast media. In five patients tumor calcifications with a disseminated sprinkled pattern were seen in CT. In MRI T_1-weighted scans the tumors were homogeneous and ...

2000-05-01

210

Genetic studies of fertility and pathogenicity in Magnaporthe grisea (Pyricularia oryzae)

A study on brain CT was made in 20 cases of typical endemic cretinism and 15 cases of normal persons. These patients from severely iodine deficient area were diagnosed as neurological endemic cretinism characterized by severe mental retardation with impairment of hearing, speech, neuromotor, etc. to varying degrees. The brain CT showed that there were many and deep depressions in cerebral cortex, especially in frontal and parietal lobes of some cretins, the lateral ventricle system was dilated, particularly in posterior part of it, and the interhemisphere fissure, lateral fissure and subarachnoid cisterns were also expanded. The CT value of cortex was higher and white matter was lower than that of normal persons. In some severe cases, the two hemispheres of brain were not the same in size. These findings above indicated that these endemic cretins had a severe retardation of brain development including cerebral cortex and white matter. In addition, some abnormal ...

211

Genetic diversity associated with in vitro and conventional bud propagation of Saccharum varieties using RAPD analysis

Crosses between field isolates of Magnaporthe grisea (anamorph, Pyricularia oryzae Cav. and Pyricularia grisea) have led to the development of fertile laboratory strains that infect goosegrass and/or weeping lovegrass. These strains may now be utilized in a rigorous genetic analysis of host species specificity and general pathogenicity. Attempts to improve the fertility of rice pathogens for the goal of undertaking a genetic analysis of host cultivar specificity have so far been unsuccessful. Crosses between M. grisea strains that infect rice, goosegrass or weeping lovegrass demonstrate that host species specificity differences between field isolates of this fungus in some cases have a complete genetic basis, and in other cases have a simple genetic basis. Crosses between a field isolate of the pathogen that infects weeping lovegrass and a field isolate that infects goosegrass have resulted in the ...

1984-01-01

212

British Library Electronic Table of Contents (United Kingdom)

Abstract Polymorphisms in the genomic DNA of eight varieties maintained by conventional bud propagation (via rhizomes) and by in vitro shoot tip cultures were detected by RAPD analysis of sugarcane varieties. The study estimated the genetic diversity induced after in vitro multiplication of these varieties. Higher (28.9%) and lower (12%) numbers of polymorphic bands were detected in plants propagated via rhizomes; the genetic similarity estimate varying from 0.63 to 0.80. Plants of SP90-3723 and SP91-1049, or RB85-5113 and SP90-3723, varieties involving greater genetic distances may be indicated as progenitors in breeding programmes. In vitro multiplication of RB86-7515, RB85-5113, RB83-5054 and SP86-42 varieties increases genetic variability, while in vitro multiplication of SP91-1049, SP...

2008-01-01

213

Aortic non communicating dissections. A study with helical CT

What is the heritable component of spinal deformities in the European sea bass (Dicentrarchus labrax)?

The evaluate the signs of aortic intramural hematoma with helical CT and the diagnostic role of this technique in patients with this condition. It was reviewed the CT findings of 396 patients submitted to emergency examinations for suspected aortic dissection from 1995 to 1999. Only 18 patients (6 women and 12 men) had CT signs of aortic intramural hematoma. Helical CT studies were carried out with the following parameters: slice thickness 10 mm, reconstruction index 10, feed 1.5 mm, conventional algorithm with minimum values of 130 kV and 125mA. All patients were examined with dynamic contrast-enhanced CT, before and after a power injection of 130 mL ionic contrast material. It was studied: hematoma localization and longitudinal extension; thickness and density of aortic wall; presence and location of intimal calcifications; integrity of intimal wall; hemo mediastinum and/or hemo thorax. Aortic wall thickening appeared as a high density crescent-shaped area at ...

2000-09-01

214

British Library Electronic Table of Contents (United Kingdom)

Malformations in farmed fish are a prime research topic as it has a major impact on fish welfare and on the economical value of the product. In this study, the genetic component of spine deformities was estimated in European sea bass, a major species of Mediterranean aquaculture, with the use of a posteriori reconstruction of pedigree with microsatellites. Our population exhibited a very high malformation rate (81%), probably due to intense swimming of fish during pre-growing. The heritability of global spine deformities was evaluated to be 0.21?0.04 on the underlying scale (0.33?0.06 for lordosis, 0.13?0.04 for scoliosis). Deformities scored by an internal or external examination turned out to be genetically the same trait (genetic correlations>0.9), although phenotypic correlations were ...

2009-01-01

215

The ribosome and the mechanism of protein synthesis

Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA

In virtually all forms of life on earth, proteins in each cell are made according to a genetic blueprint, in the form of DNA. The translation of copies of this genetic blueprint (in the form of messenger RNA) into polypeptides is performed on the ribosome, a highly complex molecular machine composed of RNAs and proteins. To this end, special adaptor molecules called transfer RNAs are lined up by the ribosome in the sequence dictated by the genetic code, such that the amino acids carried by these molecules can be linked into a polypeptide. Several cofactors are involved in these processes, some of which require energy freed up by GTP hydrolysis. Although the ribosome was discovered more than 50 years ago, its structure has only been solved recently by X-ray crystallography. Another technique, cryo-electron microscopy, is starting to contribute toward our understanding of the ribosome's function, by portraying its ...

2006-05-01

216

British Library Electronic Table of Contents (United Kingdom)

On November fourth and fifth 2010 a group of more than 100 international investigators gathered in Atlanta for the second Osteoarthritis (OA) Biomarkers Global Initiative workshop titled ''Genetics and Genomics: New Targets in OA''. The first workshop took place in April 2009 and focused on in vitro (soluble) biomarkers whilst the third and final workshop will take place in 2012 and will focus on imaging biomarkers. The OA Research Society International (OARSI) has organized the workshops. In addition to OARSI, the National Institute of Arthritis, Musculoskeletal and Skin Diseases, the Arthritis Foundation, Amgen, Genzyme, the American Orthopaedic Society for Sports Medicine and Pfizer sponsored the second meeting. It was clear from this meeting that experiments in the genetics, epigenetic...

2011-01-01

217

Predicting the subspecific identity of invasive species using distribution models: Acacia saligna as an example

British Library Electronic Table of Contents (United Kingdom)

Abstract Aim- To explore whether the subspecific genetic entities of Acacia saligna occupy different bioclimatic niches in their native and introduced ranges and whether these niches are predictable using species distribution models (SDMs). Location- Australia, South Africa and the Mediterranean Basin. Methods- Species distribution models were developed in MAXENT using six climatic variables to calculate the climatic suitability of the ranges of A.saligna. We assessed (1) the subspecific niche differences identified by SDMs using measures of niche overlap and model performance; (2) the ability of SDMs to predict the most likely subspecific genetic entities present in South Africa based on comparisons to genetic data; and (3) the ability of SDMs to predict the most likely subspecific geneti...

2011-01-01

218

Molecular phylogeography of the microturbellarian Monocelis lineata (Platyhelminthes: Proseriata) in the North-East Atlantic

British Library Electronic Table of Contents (United Kingdom)

Monocelis lineata is a complex of cryptic species (three in the Mediterranean and one in the Atlantic) widespread in midlittoral habitats. Throughout the range, populations with or without an ocular pigmented shield are found. We investigated the genetic structure of the North-East Atlantic populations with the aim of shedding light on their phylogeography and reconstructing possible patterns of recolonization after the Wrmian glaciation. Fourteen samples were investigated using cytochrome c oxidase subunit I (COI) and 13 by inter-simple sequence repeats (ISSRs). COI did not exhibit a clear pattern of decreased genetic diversity along a latitudinal gradient. Populations from Ferrol (Spain), Doolin (Ireland), and Helsingr (Denmark) showed a higher genetic variability, whereas a reduction in...

2011-01-01

219

Human cDNA mapping using fluorescence in situ hybridization

Genetic fidelity of long-term micropropagated shoot cultures of vanilla (Vanilla planifolia Andrews) as assessed by molecular markers

Genetic mapping is approached using the techniques of high resolution fluorescence in situ hybridization (FISH). This technology and the results of its application are designed to rapidly generate whole genome as tool box of expressed sequence to speed the identification of human disease genes. The results of this study are intended to dovetail with and to link the results of existing technologies for creating backbone YAC and genetic maps. In the first eight months, this approach generated 60--80% of the expressed sequence map, the remainder expected to be derived through more long-term, labor-intensive, regional chromosomal gene searches or sequencing. The laboratory has made significant progress in the set-up phase, in mapping fetal and adult brain and other cDNAs, in testing a model system for directly linking genetic and physical maps using FISH with small fragments, in setting up a database, and in establishing the ...

1993-03-04

220

British Library Electronic Table of Contents (United Kingdom)

Occurrence of genetic variants during micropropagation is occasionally encountered when the cultures are maintained in vitro for long period. Therefore, the micropropagated multiple shoots of Vanilla planifolia Andrews developed from axillary bud explants established 10 years ago were used to determine somaclonal variation using random amplified polymorphic DNA (RAPD) and intersimple sequence repeats markers (ISSR). One thousand micro-plants were established in soil of which 95 plantlets (consisting of four phenotypes) along with the mother plant were subjected to genetic analyses using RAPD and ISSR markers. Out of the 45 RAPD and 20 ISSR primers screened, 30 RAPD and 7 ISSR primers showed 317 clear, distinct and reproducible band classes resulting in a total of 30 115 bands. However, no ...

2007-01-01

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221

Genetic factors for resistance to diet-induced obesity and associated metabolic traits on mouse chromosome 17

British Library Electronic Table of Contents (United Kingdom)

Obesity is associated with increased susceptibility to dyslipidemia, insulin resistance, and hypertension, a combination of traits that comprise the traditional definition of the metabolic syndrome. Recent evidence suggests that obesity is also associated with the development of nonalcoholic fatty liver disease (NAFLD). Despite the high prevalence of obesity and its related conditions, their etiologies and pathophysiology remains unknown. Both genetic and environmental factors contribute to the development of obesity and NAFLD. Previous genetic analysis of high-fat, diet-induced obesity in C57BL/6J (B6) and A/J male mice using a panel of B6-ChrA/J/NaJ chromosome substitution strains (CSSs) demonstrated that 17 CSSs conferred resistance to high-fat, diet-induced obesity. One of these CSS st...

2009-01-01

222

Genetic and environmental interactions determine plant defences against herbivores

British Library Electronic Table of Contents (United Kingdom)

Summary 1. Plants express multiple defensive traits, but little is known about the genetic stability and phenotypic plasticity of these traits in nature. To investigate sources of variation and their potential ecological consequences for herbivores, we combined field observations of cyanogenic lima bean with laboratory experiments. 2. Field studies in South Mexico revealed a distinct variability of cyanogenic traits within and among wild lima bean populations. To differentiate among genetic variation and the impact of ambient conditions on plant phenotypes, we used seed grown plants as well as clones propagated from high (HC) and low cyanogenic (LC) wild type plants. 3. In growth chamber experiments, we cultivated plants under three intensities each of drought and salt stress, nutrient sup...

2011-01-01

223

Genetic Variation of Lodgepole Pine, Pinus contorta var. latifolia, Chemical and Physical Defenses that Affect Mountain Pine Beetle, Dendroctonus ponderosae, Attack and Tree Mortality

British Library Electronic Table of Contents (United Kingdom)

Plant secondary chemistry is determined by both genetic and environmental factors, and while large intraspecific variation in secondary chemistry has been reported frequently, the levels of genetic variation of many secondary metabolites in forest trees in the context of potential resistance against pests have been rarely investigated. We examined the effect of tree genotype and environment/site on the variation in defensive secondary chemistry of lodgepole pine, Pinus contorta var. latifolia, against the fungus, Grosmannia clavigera (formerly known as Ophiostoma clavigerum), associated with the mountain pine beetle, Dendroctonus ponderosae. Terpenoids were analyzed in phloem samples from 887, 20-yr-old trees originating from 45 half-sibling families planted at two sites. Samples were coll...

2011-01-01

224

Estimates of quantitative genetic parameters of immunological traits in the chicken.

Borderline personality traits and adult attention-deficit hyperactivity disorder symptoms: A genetic analysis of comorbidity

Three in vivo assays were used to measure the immunocompetence of chickens in two generations of a selection experiment. The obtained data were used to estimate the variance components for sire and dam for antibody production to Pasteurella multocida and Mycoplasma gallisepticum vaccines, for T-cell-mediated immunity evaluated by a phytohemagglutinin wing web assay, and for clearance of foreign particles from the circulatory system. Heritabilities of and genetic correlations among these immunological traits were calculated from the sire variance components. Heritability estimates of the immunological traits based on the sire component of variance ranged from .06 to .53, and genetic correlations among immunological traits were generally negative. PMID:1956847

1991-10-01

225

British Library Electronic Table of Contents (United Kingdom)

Abstract Previous research has established the comorbidity of adult Attention-Deficit Hyperactivity Disorder (ADHD) with different personality disorders including Borderline Personality Disorder (BPD). The association between adult ADHD and BPD has primarily been investigated at the phenotypic level and not yet at the genetic level. The present study investigates the genetic and environmental contributions to the association between borderline personality traits (BPT) and ADHD symptoms in a sample of 7,233 twins and siblings (aged 18-90 years) registered with the Netherlands Twin Register and the East Flanders Prospective Twin Survey (EFPTS) . Participants completed the Conners' Adult ADHD Rating Scales (CAARS-S:SV) and the Personality Assessment Inventory-Borderline Features Scale (PAI-BO...

2011-01-01

226

Association between chemical and genetic variation in Calophyllum inophyllum, a medicinally important tree of the Western Ghats of India

British Library Electronic Table of Contents (United Kingdom)

The objective of the present work is to study the chemical variation in Calophyllum inophyllum growing along the Western Ghats of India. Contents of dipyranocoumarins (inophyllums) in C.?inophyllum were determined to assess whether they could be used as a taxonomic marker for C.?inophyllum. This study also aims to establish inter simple sequence repeat (ISSR) markers that can be used to study genetic variation within the species and explore correlation between ISSR and chemical markers. The contents of dipyranocoumarins were estimated in seeds collected from 20 locations. Leaves from plants at the same 20 locations were assayed for ISSR variation. A dendrogram based on Nei?s genetic distance as well as principal component analysis based on dipyranocoumarins and ISSR variation clustered pla...

2011-01-01

227

An integrated genome research network for studying the genetics of alcohol addiction

British Library Electronic Table of Contents (United Kingdom)

Abstract Alcohol drinking is highly prevalent in many cultures and contributes to the global burden of disease. In fact, it was shown that alcohol constitutes 3.2% of all worldwide deaths in the year 2006 and is linked to more than 60 diseases, including cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders, injuries and foetal alcohol syndrome. Alcoholism, which has been proven to have a high genetic load, is one potentially fatal consequence of chronic heavy alcohol consumption, and may be regarded as one of the most prevalent neuropsychiatric diseases afflicting our society today. The aim of the integrated genome research network -Genetics of Alcohol Addiction--which is a German inter-/trans-disciplinary life science consortium consisting of molecular biologists,...

2010-01-01

228

Lessons Learned from the Photovoltaic Manufacturing Technology/PV Manufacturing R&D and Thin Film PV Partnership Projects

Supporting Dynamic Ad hoc Collaboration Capabilities

As the U.S. Department of Energy's (DOE's) Solar Energy Technologies Program initiates new cost-shared solar energy R&D under the Solar America Initiative (SAI), it is useful to analyze the experience gained from cost-shared R&D projects that have been funded through the program to date. This report summarizes lessons learned from two DOE-sponsored photovoltaic (PV) projects: the Photovoltaic Manufacturing Technology/PV Manufacturing R&D (PVMaT/PVMR&D) project and the Thin-Film PV Partnership project. During the past 10-15 years, these two projects have invested roughly $330 million of government resources in cost-shared R&D and leveraged another $190 million in private-sector PV R&D investments. Following a description of key findings and brief descriptions of the PVMaT/PVMR&D and Thin-Film PV Partnership projects, this report presents lessons ...

2006-09-01

229

Shared-memory performance of multiple computer terminals in parallel distributed information-processing systems

Modern HENP experiments such as CMS and Atlas involve as many as 2000 collaborators around the world. Collaborations this large will be unable to meet often enough to support working closely together. Many of the tools currently available for collaboration focus on heavy-weight applications such as videoconferencing tools. While these are important, there is a more basic need for tools that support connecting physicists to work together on an ad hoc or continuous basis. Tools that support the day-to-day connectivity and underlying needs of a group of collaborators are important for providing light-weight, non-intrusive, and flexible ways to work collaboratively. Some example tools include messaging, file-sharing, and shared plot viewers. An important component of the environment is a scalable underlying communication framework. In this paper we will describe our current progress on building a dynamic and ad hoc collaboration environment and our ...

2003-01-01

230

Investigation of the steady state and transient operating behaviour of a 20 kW pressure electrolyser

A system model for transmission of computer user's data with a finite number of regular users in a resource-sharing mode in parallel distributed information-processing systems is considered. The mini/microcomputer included in the system model is considered to be receiving the mixed arrival data of the user from a picture-phone terminal with uniformly-distributed data arrivals and a teletypewriter terminal with Erlang-distributed data arrivals. The large-memory performance of the mini/microcomputer is analysed with the mixed input data, constant service-times, synchronous transmission and single server interruption through a first-order Markov process. A simple and general approach to calculate the data arrivals from picture-phone and teletypewriter terminals and their mixed data arrivals is presented. Expressions for memory content probability and average queueing delay are derived. The application of the model is illustrated by presenting an integrated ...

1984-03-01

231

Human and rat mast cell high-affinity immunoglobulin E receptors: Characterization of putative. alpha. -chain gene products

The present paper describes the investigation of the static and dynamic behaviour of an 20 kW pressure electrolyser. The suitability for a coupled operating regime with a wind power plant has been investigated. At first the static behaviour has been analysed. The share of oxygen in hydrogen gas is lower than 0.5 Vol%. But reaching the temperature limit of 80 deg C leads to a switch off of the electrolyser, accompanied by an increase of the oxygen share in hydrogen gas up to 1.3 Vol%. Therefore, an improvement of the cooling system is necessary. Secondly, the electrolyser was excited by different step signals for load changing and finally, the electrolyser has been controlled by the power output signal of the windmill. The investigation shows that the development of a direct coupled wind-hydrogen system will be only a small step. 3 refs.

1998-07-01

232

Design, Performance and Series Production of Superconducting Trim Quadrupoles for the Large Hadron Collider

The authors have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative {alpha} subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH{sub 2}-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hydrophobic transmembrane region, and a positively charged cytoplasmic tail. The human and rat {alpha} subunits share an overall homology with one another and the immunoglobulin gene family, suggesting that they arose from a common ancestral gene and continue to share structural homology with their ligands. In addition, the rat gene is transcribed into at least three distinct forms, each of which yields a somewhat different coding sequence.

1988-03-01

233

Cross-count identity, distinctness, and the theory of internal and external relations

The Large Hadron Collider (LHC) will be equipped with several thousands of superconducting corrector magnets. Among the largest ones are the superconducting trim quadrupoles (MQTL). These twin-aperture magnets with a total mass of up to 1700 kg have a nominal gradient of 129 T/m at 1.9 K and a magnetic length of 1.3 m. Sixty MQTL are required for the LHC, 36 operating at 1.9 K in and 24 operating at 4.5 K. The paper describes the design features, and reports the measured quench performance and magnetic field quality of the production magnets. The MQTL magnet production is shared between CERN and industry. This sharing is simplified due to the modular construction, common to all twin-aperture correctors.

2006-01-01

234

British Library Electronic Table of Contents (United Kingdom)

Baxter (Australas J Philos 79:449?464, 2001) proposes an ingenious solution to the problem of instantiation based on his theory of cross-count identity. His idea is that where a particular instantiates a universal it shares an aspect with that universal. Both the particular and the universal are numerically identical with the shared aspect in different counts. Although Baxter does not say exactly what a count is, it appears that he takes ways of counting as mysterious primitives against which different numerical identities are defined. In contrast, I defend the idea?suggested, though not quite endorsed, by Baxter himself?that counts are independent dimensions of numerical identity. Different ways of counting are explained by the existence of these different sorts of identity (i.e., counts)...

2010-01-01

235

Communication and Round Efficient Information Checking Protocol

An empirical analysis of petroleum demand for Indonesia. An application of the cointegration approach

In this paper, we present a very important primitive called Information Checking Protocol (ICP) which plays an important role in constructing statistical Verifiable Secret Sharing (VSS) and Weak Secret Sharing (WSS) protocols. Informally, ICP is a tool for authenticating messages in the presence of computationally unbounded corrupted parties. Here we extend the basic bare-bone definition of ICP, introduced by Rabin et al. and then present an ICP that attains the best communication complexity and round complexity among all the existing ICPs in the literature. We also show that our ICP satisfies several interesting properties such as linearity property which is an important requirement in many applications of ICP. Though not presented in this paper, we can design communication and round efficient statistical (i.e involves negligible error probability in computation) VSS and Multiparty Computation (MPC) protocol using our new ICP.

2010-01-01

236

solQTL: a tool for QTL analysis, visualization and linking to genomes at SGN database

This paper uses selection criteria from various models in a bounds testing approach to cointegration to estimate the price and income elasticities of demand for total petroleum products (gasoline and diesel) and gasoline share in total products in Indonesia. The results suggest that both total products and gasoline share estimates are more responsive to changes in income than changes in the real price of petroleum products. These results have important policy implications as they suggest that policy makers may need to use market-based pricing policies and other policies such as public enlightenment in addition to regulations like minimum energy efficiency standards to promote efficiency and conservation and curb the rising consumption of petroleum products in Indonesia. (author)

2009-11-15

237

Why is it getting more difficult to successfully artificially inseminate dairy cows?*

BackgroundA common approach to understanding the genetic basis of complex traits is through identification of associated quantitative trait loci (QTL). Fine mapping QTLs requires...Full Text Available

238

Variation in Nicotine Consumption in Inbred Mice Is Not Linked to Orosensory Ability

Successfully using artificial insemination (AI) is defined as getting cows pregnant when the farmer wants them in-calf and making the best use of appropriate genetic potential. Over the past...Full Text Available

2008-08-01

239

Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans

Genetic studies of nicotine addiction in mice have utilized the oral self-administration model. However, it is unclear if strain differences in nicotine consumption are influenced by variation in bitter...Full Text Available

2009-01-01

240

Type I Collagen Is a Genetic Modifier of Matrix Metalloproteinase 2 in Murine Skeletal Development

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

2011-04-01

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241

Tumour-stromal interactions: Phenotypic and genetic alterations in mammary stroma - implications for tumour progression

Recessive inactivating mutations in human matrix metalloproteinase 2 (MMP2, gelatinase A) are associated with syndromes that include abnormal facial appearance, short stature, and severe bone...Full Text Available

2007-06-01

242

Transposable elements in fish functional genomics: technical challenges and perspectives

In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in...Full Text Available

2001-01-01

243

Transgenesis in Xenopus using the Sleeping Beauty transposon system

The recent introduction of several transposable elements in zebrafish opens new frontiers for genetic manipulation in this important vertebrate model. This review discusses transposable elements as...Full Text Available

2007-01-01

244

The high Andes, gene flow and a stable hybrid zone shape the genetic structure of a wide-ranging South American parrot

Transposon-based integration systems have been widely used for genetic manipulation of invertebrate and plant model systems. In the past decade, these powerful tools have begun to be used in...Full Text Available

2009-07-01

245

The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN study*

BackgroundWhile the gene flow in some organisms is strongly affected by physical barriers and geographical distance, other highly mobile species are able to overcome such constraints....Full Text Available

246

The Spectrum of Monogenic Autoinflammatory Syndromes: Understanding Disease Mechanisms and Use of Targeted Therapies

Chronically elevated interleukin-6 (IL-6) affects lipid and lipoprotein metabolism. Individuals genetically predisposed to higher IL-6 secretion may be at risk of dyslipidemia, especially during the...Full Text Available

2008-08-01

247

The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific

Monogenic autoinflammatory diseases encompass a distinct and growing clinical entity of multisystem inflammatory diseases with known genetic defects in the innate immune system. The diseases...Full Text Available

2008-07-01

248

The Genetic Basis of Cellular Morphogenesis in the Filamentous Fungus Neurospora crassa

The world's oceans contain a complex mixture of micro-organisms that are for the most part, uncharacterized both genetically and biochemically. We report here a metagenomic study of the marine planktonic...Full Text Available

2007-03-01

249

The Dystrophin Complex Controls BK Channel Localization and Muscle Activity in Caenorhabditis elegans

Cellular polarity is a fundamental property of every cell. Due to their extremely fast growth rate (≥1 μm/s) and their highly elongated form, filamentous fungi represent a prime example...Full Text Available

2003-11-01

250

Temperature regulates limb length in homeotherms by directly modulating cartilage growth

Genetic defects in the dystrophin-associated protein complex (DAPC) are responsible for a variety of pathological conditions including muscular dystrophy, cardiomyopathy, and vasospasm. Conserved DAPC...Full Text Available

2009-12-01

251

Technical approaches for mouse models of human disease

Allen's Rule documents a century-old biological observation that strong positive correlations exist among latitude, ambient temperature, and limb length in mammals. Although genetic selection for thermoregulatory...Full Text Available

2008-12-09

252

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

The mouse is the leading organism for disease research. A rich resource of genetic variation occurs naturally in inbred and special strains owing to spontaneous mutations. However, one can also obtain...Full Text Available

2011-05-01

253

Stressed-Induced TMEM135 Protein Is Part of a Conserved Genetic Network Involved in Fat Storage and Longevity Regulation in Caenorhabditis elegans

The development of new methods for gene addition to mammalian genomes is necessary to overcome the limitations of conventional genetic engineering strategies. Although a variety of DNA-modifying enzymes...Full Text Available

2011-09-01

254

Specific genetic modifications of domestic animals by gene targeting and animal cloning

Disorders of mitochondrial fat metabolism lead to sudden death in infants and children. Although survival is possible, the underlying molecular mechanisms which enable this outcome have not yet been...Full Text Available

255

Speciation genetics: current status and evolving approaches

The technology of gene targeting through homologous recombination has been extremely useful for elucidating gene functions in mice. The application of this technology was thought impossible in the large...Full Text Available

256

Soluble Epoxide Hydrolase Inhibition: Targeting Multiple Mechanisms of Ischemic Brain Injury with a Single Agent

The view of species as entities subjected to natural selection and amenable to change put forth by Charles Darwin and Alfred Wallace laid the conceptual foundation for understanding speciation. Initially...Full Text Available

2010-06-12

257

Single nucleotide polymorphisms for assessing genetic diversity in castor bean (Ricinus communis)

SummarySoluble epoxide hydrolase (sEH) is a key enzyme in the metabolic conversion and degradation of P450 eicosanoids called epoxyeicosatrienoic acids (EETs). Genetic variations...Full Text Available

2009-03-01

258

Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes

BackgroundCastor bean (Ricinus communis) is an agricultural crop and garden ornamental that is widely cultivated and has been introduced worldwide. Understanding...Full Text Available

259

Sex modifies exercise and cardiac adaptation in mice

BackgroundRecent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects...Full Text Available

260

Sex determines the expression level of one third of the actively expressed genes in bovine blastocysts

How an individual’s sex and genetic background modify cardiac adaptation to increased workload is a topic of great interest. We systematically evaluated morphological and physiological...Full Text Available

2004-12-01

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261

Although genetically identical for autosomal Chrs (Chr), male and female preimplantation embryos could display sex-specific transcriptional regulation. To illustrate sex-specific differences at the...Full Text Available

2010-02-23

262

STR References 3001-3250

Root Suberin Forms an Extracellular Barrier That Affects Water Relations and Mineral Nutrition in Arabidopsis

Journal of Human Genetics. 82: 873-882. 3134. Schulz, I., Schneider, P. M., Olek, K, Rothschild, M. A., and Tsokos, M. (2006) Examination of Postmortem Animal Interference to Human...

2009-03-16

263

Role of the nac gene product in the nitrogen regulation of some NTR-regulated operons of Klebsiella aerogenes.

Though central to our understanding of how roots perform their vital function of scavenging water and solutes from the soil, no direct genetic evidence currently exists to support the foundational model...Full Text Available

2009-05-01

264

Remobilization of Tol2 transposons in Xenopus tropicalis

A positive, genetic selection against the activity of the nitrogen regulatory (NTR) system was used to isolate insertion mutations affecting nitrogen regulation in Klebsiella aerogenes. Two classes...Full Text Available

1990-12-01

265

Research - Keyword Index

Wastenet

...and biological processes acting on recruitment and post-recruitment EU-Agrinet - Project sheet: Biological performance testing methodology to evaluate the durability of plywood as a quality indicator ... Project sheet: Biological performance testing methodology to evaluate the durability of plywood as a quali EU-Agrinet - Project sheet: Genetic evaluation of European ...

266

Relationship between mRNA secondary structure and sequence variability in Chloroplast genes: possible life history implications

BackgroundThe Class II DNA transposons are mobile genetic elements that move DNA sequence from one position in the genome to another. We have previously demonstrated that the naturally...Full Text Available

267

Regulation of G1 Cell Cycle Progression

BackgroundSynonymous sites are freer to vary because of redundancy in genetic code. Messenger RNA secondary structure restricts this freedom, as revealed by previous findings in...Full Text Available

268

Recovery of Pathogenic Measles Virus from Cloned cDNA

Most genetic changes that promote tumorigenesis involve dysregulation of G1 cell cycle progression. A key regulatory site in G1 is a growth factor–dependent restriction point (R) where cells...Full Text Available

2010-11-01

269

Rapid in vivo transport and catabolism of human apolipoprotein A-IV-1 and slower catabolism of the apoA-IV-2 isoprotein.

Reverse genetics technology so far established for measles virus (MeV) is based on the Edmonston strain, which was isolated several decades ago, has been passaged in nonlymphoid cell lines, and is no...Full Text Available

2000-07-01

270

Radiation exposure due to X-rays of the hip joint in babies

Apolipoprotein (apo) A-IV is a polymorphic, intestinally derived apolipoprotein that is genetically linked to and similar in structure to apoA-I, the major apolipoprotein in high density lipoproteins...Full Text Available

1993-08-01

271

QSAR Studies of Copper Azamacrocycles and Thiosemicarbazones

Exact anatomic knowledge about the location of the gonads and the application of corresponding measures of radiation protection are the preconditions for an efficient reduction of the danger of a possible genetic damage as a result of radiation exposition during X-ray examination of the hip joint of newborns. (VJ).

272

Public interest in predictive genetic testing, including direct-to-consumer testing, for susceptibility to major depression: preliminary findings

Genetic algorithms (GA) were used to develop specific copper metal-ligand force field parameters for the MM3 force field, from a combination of crystallographic structures and ab initio...Full Text Available

2005-08-25

273

Programmed Cell Death during Pollination-Induced Petal Senescence in Petunia1

The past decade has seen rapid advances in the identification of associations between candidate genes and a range of common multifactorial disorders. This paper evaluates public attitudes towards the...Full Text Available

2010-01-01

274

Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error

Petal senescence, one type of programmed cell death (PCD) in plants, is a genetically controlled sequence of events comprising its final developmental stage. We characterized the pollination-induced...Full Text Available

2000-04-01

275

Population genetic analysis of large sequence polymorphisms in Plasmodium falciparum blood-stage antigens

BackgroundWith the advent of increasingly efficient means to obtain genetic information, a great insurgence of data has resulted, leading to the need for methods for analyzing this...Full Text Available

276

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

Plasmodium falciparum, the causative agent of human malaria, invades host erythrocytes using several proteins on the surface of the invasive merozoite, which have been proposed...Full Text Available

2010-03-01

277

Phylometabonomic Patterns of Adaptation to High Fat Diet Feeding in Inbred Mice

Human longevity is in part genetically determined, and the insulin/IGF-1 signal transduction (IIS) pathway has consistently been implicated. In humans, type 2 diabetes is a frequent disease that results...Full Text Available

278

Phylogenetic Network for European mtDNA

Insulin resistance plays a central role in type 2 diabetes and obesity, which develop as a consequence of genetic and environmental factors. Dietary changes including high fat diet (HFD) feeding promotes...Full Text Available

279

Persistent Staphylococcus aureus Colonization Is Not a Strongly Heritable Trait in Amish Families

The sequence in the first hypervariable segment (HVS-I) of the control region has been used as a source of evolutionary information in most phylogenetic analyses of mtDNA. Population genetic inference...Full Text Available

2001-06-01

280

Pathophysiological, Genetic and Gene Expression Features of a Novel Rodent Model of the Cardio-Metabolic Syndrome

About 20% of adults are persistently colonized with S. aureus in the anterior nares. Host genetic factors could contribute susceptibility to this phenotype. The objective of...Full Text Available

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281

Parent-of-origin effects on voluntary exercise levels and body composition in mice

BackgroundComplex etiology and pathogenesis of pathophysiological components of the cardio-metabolic syndrome have been demonstrated in humans and animal models.Methodology/Principal...Full Text Available

282

PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah^enu2 mice

Despite the health-related benefits of exercise, many people do not engage in enough activity to realize the rewards, and little is known regarding the genetic or environmental components that account...Full Text Available

2010-01-01

283

Olfactory copy number association with age at onset of Alzheimer disease

Phenylketonuria (PKU) is a common genetic disorder in humans that arises from deficient activity of phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine....Full Text Available

2007-01-05

284

Oil palm (Elaeis guineensis Jacq.) tissue culture ESTs: Identifying genes associated with callogenesis and embryogenesis

Objectives:Copy number variants (CNVs) have been recognized as a source of genetic variation that contributes to disease phenotypes. Alzheimer disease (AD) has high heritability...Full Text Available

2011-04-12

285

Nuclear reprogramming in mammalian somatic cell nuclear cloning

BackgroundOil palm (Elaeis guineensis Jacq.) is one of the most important oil bearing crops in the world. However, genetic improvement of oil palm through conventional...Full Text Available

286

Nuclear Receptor Rev-erb Alpha (Nr1d1) Functions in Concert with Nr2e3 to Regulate Transcriptional Networks in the Retina

Nuclear cloning is still a developing technique used to create genetically identical animals by somatic cell nuclear transfer into unfertilized eggs. Despite an intensive effort in a number...Full Text Available

2004-01-01

287

Novel Multilocus Measure of Linkage Disequilibrium to Estimate Past Effective Population Size

The majority of diseases in the retina are caused by genetic mutations affecting the development and function of photoreceptor cells. The transcriptional networks directing these processes are regulated...Full Text Available

288

Myofibrillogenesis in the developing zebrafish heart: A functional study of tnnt2

Linkage disequilibrium (LD) between densely spaced, polymorphic genetic markers in humans and other species contains information about historical population size. Inferring past population size is of...Full Text Available

2003-04-01

289

Mycolic Acid Analysis by High-Performance Liquid Chromatography for Identification of Mycobacterium Species

Various hypotheses have been proposed to explain the molecule processes of sarcomere assembly, partially due to the lack of systematic genetic studies of sarcomeric genes in an in vivo...Full Text Available

2009-07-15

290

Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins.

Mycobacterium tuberculosis is the etiologic agent of tuberculosis and can be accurately detected by laboratories using commercial genetic tests. Nontuberculosis mycobacteria (NTM) causing other mycobacterioses...Full Text Available

2001-10-01

291

Mutation analysis of 272 Spanish families affected by autosomal recessive retinitis pigmentosa using a genotyping microarray

In our quest for novel genes required for the development of the embryonic peripheral nervous system (PNS), we have performed three genetic screens using MAb 22C10 as a marker of terminally differentiated...Full Text Available

2000-12-01

292

Multivariate analyses reveal common and drug specific genetic influences on responses to four drugs of abuse

PurposeRetinitis pigmentosa (RP) is a genetically heterogeneous disorder characterized by progressive loss of vision. The aim of this study was to identify the causative mutations...Full Text Available

293

Molecular mechanisms of genetic adaptation to xenobiotic compounds.

Vulnerability to abused drugs is influenced by multiple genes unique to each drug as well as to risk genes for polydrug abuse. If several inbred mouse strains respond to different drugs similarly,...Full Text Available

2008-11-01

294

Molecular biological enhancement of coal biodesulfurization. Final report, October 1988--December 1991

Microorganisms in the environment can often adapt to use xenobiotic chemicals as novel growth and energy substrates. Specialized enzyme systems and metabolic pathways for the degradation of man-made...Full Text Available

1992-12-01

295

Mobilizing diversity: transposable element insertions in genetic variation and disease

The overall objective of this project was to use molecular genetics to develop strains of bacteria with enhanced ability to remove sulfur from coal, and to obtain data that will allow the performance and economics of a coal biodesulfurization process to be predicted. (VC)

1991-12-01

296

Microsatellite-based genetic diversity and population structure of domestic sheep in northern Eurasia

Transposable elements (TEs) comprise a large fraction of mammalian genomes. A number of these elements are actively jumping in our genomes today. As a consequence, these insertions provide a source...Full Text Available

297

Mapping Quantitative Trait Loci Controlling Milk Production in Dairy Cattle by Exploiting Progeny Testing

BackgroundIdentification of global livestock diversity hotspots and their importance in diversity maintenance is essential for making global conservation efforts. We screened 52...Full Text Available

298

Mammalian life-span determinant p66^shcA mediates obesity-induced insulin resistance

We have exploited ``progeny testing'' to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny...Full Text Available

1995-02-01

299

Lymphocytes, neuropeptides, and genes involved in alopecia areata

Obesity and metabolic syndrome result from excess calorie intake and genetic predisposition and are mechanistically linked to type II diabetes and accelerated body aging; abnormal nutrient and insulin...Full Text Available

2010-07-27

300

Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies

Many lessons in autoimmunity — particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology — can be learned from the study of alopecia...Full Text Available

2007-08-01

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301

Interpopulation hybridization results in widespread viability selection across the genome in Tigriopus californicus

Recently, genome-wide association studies (GWAS) have linked the human LIN28B locus to height and timing of menarche [1-Full Text Available

2010-07-01

302

Integrase-directed recovery of functional genes from genomic libraries

BackgroundGenetic interactions within hybrids influence their overall fitness. Understanding the details of these interactions can improve our understanding of speciation. One experimental...Full Text Available

303

Insecticidal properties of genetically engineered baculoviruses expressing an insect juvenile hormone esterase gene.

Large population sizes, rapid growth and 3.8 billion years of evolution firmly establish microorganisms as a major source of the planet's biological and genetic diversity. However, up to 99% of the...Full Text Available

2009-09-01

304

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Exploring the possibility of enhancing the properties of baculoviruses as biological control agents of insect pests, we tested the effect of expressing an insect gene (jhe) encoding juvenile hormone...Full Text Available

1992-05-01

305

Inferring gene regulatory networks from asynchronous microarray data with AIRnet

As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc...Full Text Available

2010-02-02

306

Infant Milk Feeding Influences Adult Bone Health: A Prospective Study from Birth to 32 Years

BackgroundModern approaches to treating genetic disorders, cancers and even epidemics rely on a detailed understanding of the underlying gene signaling network. Previous work has...Full Text Available

307

Increased Ethanol Productivity in Xylose-Utilizing Saccharomyces cerevisiae via a Randomly Mutagenized Xylose Reductase?

BackgroundPeak bone mass, attained by early adulthood, is influenced by genetic and life-style factors. Early infant feeding and duration of breastfeeding in particular, associate...Full Text Available

308

In Vivo RNAi Screening Identifies Regulators of Actin Dynamics as Key Determinants of Lymphoma Progression

Baker's yeast (Saccharomyces cerevisiae) has been genetically engineered to ferment the pentose sugar xylose present in lignocellulose biomass. One of the reactions controlling the...Full Text Available

2010-12-01

309

Improvement of Aroma in Transgenic Potato As a Consequence of Impairing Tuber Browning

Mouse models have dramatically improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic...Full Text Available

2009-10-01

310

Impaired replication dynamics at the FRA3B common fragile site

Sensory analysis studies are critical in the development of quality enhanced crops, and may be an important component in the public acceptance of genetically modified foods. It has recently been established...Full Text Available

311

Impact of genetic changes to the CRPV genome and their application to the study of pathogenesis in vivo

Chromosomal common fragile sites (CFSs) are genetically unstable regions of the genome that are induced by conditions that impair DNA replication. In this report, we show that treatment with the DNA...Full Text Available

2010-01-01

312

Immortalizing the Complexity of Cancer Metastasis Genetic Features of Lethal Metastatic Pancreatic Cancer Obtained from Rapid Autopsy

The cottontail rabbit papillomavirus (CRPV)/rabbit model has been used to study oncogenicity and immunogenicity of different antigens from the papillomavirus genome and has therefore served...Full Text Available

2007-02-20

313

Identification of genetic variation and haplotype structure of the canine ABCA4 gene for retinal disease association studies

The virtual lack of well-characterized metastatic pancreatic cancer tissues for study has limited systematic studies of the metastatic process of this deadly disease. To address this important...Full Text Available

2005-05-01

314

Identification of genes and haplotypes that predict rheumatoid arthritis using random forests

Over 200 mutations in the retina specific member of the ATP-binding cassette transporter super-family (ABCA4) have been associated with a diverse group of human retinal diseases....Full Text Available

2010-10-01

315

Identification of a Copper-Responsive Two-Component System on the Chromosome of Escherichia coli K-12

Random forest (RF) analysis of genetic data does not require specification of the mode of inheritance, and provides measures of variable importance that incorporate interaction effects. In this paper...Full Text Available

316

Ichthyosis follicularis, alopecia, and photophobia (IFAP) syndrome

Using a genetic screen we have identified two chromosomal genes, cusRS (ylcA ybcZ), from Escherichia coli K-12 that encode a two-component, signal...Full Text Available

2000-10-01

317

ICC-MY coordinate smooth muscle electrical and mechanical activity in the murine small intestine

The IFAP syndrome is a rare X-linked genetic disorder reported in nearly 40 patients. It is characterized by the triad of Ichthyosis Follicularis, Alopecia, and Photophobia from birth. Other features...Full Text Available

318

How DNA coiling enhances target localization by proteins

BackgroundAnimals carrying genetic mutations have provided powerful insights into the role of interstitial cells of Cajal (ICC) in motility. One classic model is...Full Text Available

2010-05-01

319

High genetic variability and low local diversity in a population of arbuscular mycorrhizal fungi

Many genetic processes depend on proteins interacting with specific sequences on DNA. Despite the large excess of nonspecific DNA in the cell, proteins can locate their targets rapidly. After initial...Full Text Available

2008-10-14

320

Heritability of Lumbar Trabecular Bone Mechanical Properties in Baboons

Arbuscular mycorrhizal fungi (AMF) are ecologically important root symbionts of most terrestrial plants. Ecological studies of AMF have concentrated on differences between species; largely assuming...Full Text Available

2004-02-24

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321

Hereditary Connective Tissue Diseases in Young Adult Stroke: A Comprehensive Synthesis

Genetic effects on mechanical properties have been demonstrated in rodents, but not confirmed in primates. Our aim was to quantify the proportion of variation in vertebral trabecular bone mechanical...Full Text Available

2010-03-01

322

Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein*

Though the genetic background of ischaemic and haemorrhagic stroke is often polygenetic or multifactorial, it can in some cases result from a monogenic disease, particularly in young adults. Besides...Full Text Available

323

Genome-wide detection and characterization of positive selection in human populations

Chemical genetics is an emerging approach to investigate the biology of host-pathogen interactions. We screened several inhibitors of ATP-dependent DNA motors and detected the gyrase B inhibitor coumermycin...Full Text Available

2010-12-10

324

Genome-wide characterization of simple sequence repeats in cucumber (Cucumis sativus L.)

With the advent of dense maps of human genetic variation, it is now possible to detect positive natural selection across the human genome. Here we report an analysis of over 3 million polymorphisms...Full Text Available

2007-10-18

325

Genetics of the mammalian phenylalanine hydroxylase system. Studies of human liver phenylalanine hydroxylase subunit structure and of mutations in phenylketonuria.

BackgroundCucumber, Cucumis sativus L. is an important vegetable crop worldwide. Until very recently, cucumber genetic and genomic resources, especially molecular...Full Text Available

326

Genetics and molecular pathology of Stargardt-like macular degeneration

Phenylalanine hydroxylase was purified from crude extracts of human livers which show enzyme activity by usine two different methods: (a) affinity chromatography and (b) immunoprecipitation with an...Full Text Available

1979-08-01

327

Genetic heterogeneity in human T-cell leukemia/lymphoma virus type II.

Stargardt-like macular degeneration (STGD3) is an early onset, autosomal dominant macular degeneration. STGD3 is characterized by a progressive pathology, the loss of central vision, atrophy...Full Text Available

2010-05-01

328

Genetic effects of introgression genomic components from Sea Island cotton (Gossypium barbadense L.) on fiber related traits in upland cotton (G. hirsutum L.)

DNA from the peripheral blood mononuclear cells of 17 different individuals infected with human T-cell lymphoma/leukemia virus type II (HTLV-II) was successfully amplified by the polymerase chain reaction...Full Text Available

1993-03-01

329

British Library Electronic Table of Contents (United Kingdom)

The germplasm with exotic genomic components especially from Sea Island cotton (Gossypium barbadense L. Gb) is the dominant genetic resources to enhance fiber quality of upland cotton (G. hirsutum L., Gh). Due to low efficiency of phenotypic evaluation and selection on fiber quality, genetic dissection of favorable alleles using molecular markers is essential. Genetic dissection on putative Gb introgressions related to fiber traits were conducted by SSR markers with mapping populations derived from a cross between Luyuan343 (LY343), a superior fiber quality introgression line (IL) with genomic components from Gb, and an elite Upland cotton cv. Lumianyan#22 (LMY22). Among 82 polymorphic loci screened out from 4050 SSRs, 42 were identified as putative introgression alleles. A total of 29 fib...

2011-01-01

330

Genetic association between the COMT genotype and urinary levels of tea polyphenols and their metabolites among daily green tea drinkers

Genetic architecture of voluntary exercise in an advanced intercross line of mice

Available in vitro and animal studies have shown cancer protective effects of tea polyphenols. Recent study suggests a greater protective effect of green tea intake on breast cancer...Full Text Available

331

Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans

Exercise is essential for health, yet the amount, duration, and intensity that individuals engage in are strikingly variable, even under prescription. Our focus was to identify the locations and effects...Full Text Available

2010-07-01

332

Genetic Variation at the Mitochondrial DNA 9-bp Repeat Locus in the Sakha of Siberia

Neurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations,...Full Text Available

2010-03-01

333

Genetic Susceptibility for Individual Cooperation Preferences: The Role of Monoamine Oxidase A Gene (MAOA) in the Voluntary Provision of Public Goods

... 16223, 16292, and 16295, which classify them as haplogroup W (Richards et al. 2000). The sample that was ... belonged to haplogroup B, 2 individuals belonged to haplogroup W, and 1 individual belonged to ...

334

Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

In the context of social dilemmas, previous research has shown that human cooperation is mainly based on the social norm of conditional cooperation. While in most cases individuals behave according...Full Text Available

335

Genetic Modulation of GABA Levels in the Anterior Cingulate Cortex by GAD1 and COMT

It is widely accepted that specific human papillomavirus (HPV) types are the central etiologic agent of cervical carcinogenesis. However, a number of infected women do not develop invasive lesions,...Full Text Available

336

Genetic Heterogeneity in Severe Congenital Neutropenia: How Many Aberrant Pathways Can Kill a Neutrophil?

γ-Aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in...Full Text Available

2010-07-01

337

Genetic Evidence for Inhibition of Bacterial Division Protein FtsZ by Berberine

Purpose of reviewSevere congenital neutropenia (SCN) is a primary immunodeficiency in which lack of neutrophils causes inadequate innate immune host response to bacterial...Full Text Available

2007-12-01

338

Genetic Diversity in Blastomyces dermatitidis: Implications for PCR Detection in Clinical and Environmental Samples

BackgroundBerberine is a plant alkaloid that is widely used as an anti-infective in traditional medicine. Escherichia coli exposed to berberine form filaments, suggesting...Full Text Available

339

Genetic Association Analysis of NOS1 and Methamphetamine-Induced Psychosis Among Japanese

SummaryBlastomycosis is a serious and potentially fatal infection by the thermally dimorphic fungus Blastomyces dermatitidis. PCR assays targeting the BAD-1 virulence...Full Text Available

2010-03-01

340

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1?

The neuronal nitric oxide synthase gene (NOS1) is located at 12q24, a susceptibility region for schizophrenia, and produces nitric oxide (NO). NO has been reported to play important...Full Text Available

2011-03-01

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341

Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice

Keap1 regulates Nrf2 activity in response to xenobiotic and oxidative stresses. Nrf2 is an essential regulator of cytoprotective genes. Keap1-null mice are lethal by weaning age due...Full Text Available

2010-06-01

342

Generation of Novel Bacterial Regulatory Proteins That Detect Priority Pollutant Phenols

Cigarette smoke (CS) induces recruitment of inflammatory cells in the lungs leading to the generation of reactive oxygen species (ROS), which are involved in lung inflammation and injury. Nicotinamide...Full Text Available

2008-05-01

343

Gene-gene and gene-environment interactions: new insights into the prevention, detection and management of coronary artery disease

The genetic systems of bacteria that have the ability to use organic pollutants as carbon and energy sources can be adapted to create bacterial biosensors for the detection of industrial pollution....Full Text Available

2000-01-01

344

Gene-Environment Interactions and Epigenetic Basis of Human Diseases

Despite the recent success of genome-wide association studies (GWASs) in identifying loci consistently associated with coronary artery disease (CAD), a large proportion of the genetic components of...Full Text Available

345

Frequent Promoter Hypermethylation of the APC and RASSF1A Tumour Suppressors in Parathyroid Tumours

Most human diseases are related in some way to the loss or gain in gene functions. Regulation of gene expression is a complex process. In addition to genetic mechanisms, epigenetic causes are...Full Text Available

2008-01-01

346

Familial occurrence of unilateral giant breasts in Nigeria: a possible new genetic entity.

BackgroundParathyroid adenomas constitute the most common entity in primary hyperparathyroidism, and although recent advances have been made regarding the underlying genetic cause...Full Text Available

347

Extracellular Administration of BCL2 Protein Reduces Apoptosis and Improves Survival in a Murine Model of Sepsis

Four cases of unilateral giant breasts from two unrelated families are described. Three of the patients were managed surgically. It is speculated from a review of available published reports that this...Full Text Available

1984-04-01

348

Expression Signatures of Metastatic Capacity in a Genetic Mouse Model of Lung Adenocarcinoma

BackgroundSevere sepsis and septic shock are major causes of morbidity and mortality worldwide. In experimental sepsis there is prominent apoptosis of various cell types, and genetic...Full Text Available

349

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

BackgroundNon-small cell lung cancer (NSCLC) is the foremost cause of cancer-related death in Western countries, which is due partly to the propensity of NSCLC cells to metastasize....Full Text Available

350

Estimation of effective population sizes from data on genetic markers

The incidence of melanoma is increasing more than any other cancer, and knowledge of its genetic alterations is limited. To systematically analyze such alterations, we performed whole-exome...Full Text Available

2011-05-01

351

Establishing the scientific and mechanistic framework for a GIN (Genetic Improvement Network)

The effective population size (N_e) is an important parameter in ecology, evolutionary biology and conservation biology. It is, however, notoriously difficult to estimate,...Full Text Available

2005-07-29

352

Environmental Research Database

Objectives7. (b) Objectives General background Livestock production accounts for 70% of the agricultural land on the planet. Given that demand for livestock products is expected to double by 2050 it is vital that we identify less polluting ways of production, spanning both intensive and extensive systems. Northern Europe is one of the few parts of the globe where climate change is expected to be neutral or even benefit agricultural productivity. Hence it is likely to make an even more important co [continued...]DescriptionRuminant genetic improvement can play an important role in developing livestock systems that will be sustainable in the future, and produce food in an environmentally friendly manner. Also, genetic improvement of livestock is a particularly cost-effective technology, producing permanent and cumulative changes in performance. Moran et al (2007) showed the very high value of animal and plant genetics ...

2010-01-31

353

Engineering of a psychrophilic bacterium for the bioremediation of aromatic compounds

Engineering ligand-responsive RNA controllers in yeast through the assembly of RNase III tuning modules

Microbial degradation of aromatic hydrocarbons has been studied with the aim of developing applications for the removal of toxic compounds. Efforts have been directed toward the genetic manipulation...Full Text Available

2010-05-01

354

Djinn Lite: a tool for customised gene transcript modelling, annotation-data enrichment and exploration

The programming of cellular networks to achieve new biological functions depends on the development of genetic tools that link the presence of a molecular signal to gene-regulatory activity. Recently,...Full Text Available

2011-07-01

355

Dissecting the Genetic Components of Adaptation of Escherichia coli to the Mouse Gut

BackgroundThere is an ever increasing rate of data made available on genetic variation, transcriptomes and proteomes. Similarly, a growing variety of bioinformatic programs are becoming...Full Text Available

356

Differential effects of the mottled yellow and pseudoagouti phenotypes on immunocompetence in Avy/a mice.

While pleiotropic adaptive mutations are thought to be central for evolution, little is known on the downstream molecular effects allowing adaptation to complex ecologically relevant environments. Here...Full Text Available

2008-01-01

357

Development of an extrachromosomal cloning vector system for use in Borrelia burgdorferi

Whereas genetic factors are known to influence both susceptibility to carcinogens and the capacity to respond to specific antigenic stimuli, little is known regarding the influence of phenotype per...Full Text Available

1984-04-01

358

Detection of genetic mutations in repetitive DNA sequences in somatic human cells after low-dose irradiation; Nachweis genetischer Veraenderungen in repetitiven DNA-Sequenzen in somatischen menschlichen Zellen nach Bestrahlung im niedrigen Dosisbereich

Molecular genetic analysis of Borrelia burgdorferi, the cause of Lyme disease, has been hampered by the absence of any means of efficient generation, identification, and complementation...Full Text Available

2000-04-25

359

Detection and Identification of Ciprofloxacin-Resistant Yersinia pestis by Denaturing High-Performance Liquid Chromatography

No abstract prepared

1998-03-01

360

Destructive effects of smoking on molecular and genetic factors of periodontal disease

Denaturing high-performance liquid chromatography (DHPLC) has been used extensively to detect genetic variation. We used this method to detect and identify Yersinia pestis KIM5 ciprofloxacin-resistant...Full Text Available

2003-07-01

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25

361

Design of 240,000 orthogonal 25mer DNA barcode probes

Many epidemiological evidences have proven the association between smoking and periodontal disease. The causality can be further established by linking findings of traditional epidemiological studies...Full Text Available

362

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

DNA barcodes linked to genetic features greatly facilitate screening these features in pooled formats using microarray hybridization, and new tools are needed to design large sets of barcodes to allow...Full Text Available

2009-02-17

363

De Novo Induction of Genetically Engineered Brain Tumors In Mice Using Plasmid DNA

OBJECTIVEPrevious studies showed that genetic deletion or pharmacological blockade of the receptor for advanced glycation end products (RAGE) prevents the early structural changes...Full Text Available

2010-08-01

364

Cytogenetic analysis of three sea catfish species (Teleostei, Siluriformes, Ariidae) with the first report of Ag-NOR in this fish family

Spontaneous mouse models of cancer show promise to more accurately recapitulate human disease and predict clinical efficacy. Transgenic mice or viral vectors have been required to generate spontaneous...Full Text Available

2009-01-15

365

Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum

Despite their ecological and economical importance, fishes of the family Ariidae are still genetically and cytogenetically poorly studied. Among the 133 known species of ariids, only eight have been...Full Text Available

2010-04-01

366

Construction of DNA recognition sites active in Haemophilus transformation.

The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design....Full Text Available

367

Construction and Characterization of Genetically Defined aro omp Mutants of Enterotoxigenic Escherichia coli and Preliminary Studies of Safety and Immunogenicity in Humans

Competent Haemophilus cells recognize and preferentially take up Haemophilus DNA during genetic transformation. This preferential uptake is correlated with the presence on incoming DNA of an 11-base-pair...Full Text Available

1982-04-01

368

Confocal microscopy for the analysis of siRNA delivery by polymeric nanoparticles

Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in travelers to countries where the disease is endemic and causes a major disease burden in the indigenous population,...Full Text Available

2001-08-01

369

Complex Integration of Matrix, Oxidative Stress, and Apoptosis in Genetic Emphysema

Clinical applications of genetic therapies, including delivery of short, interfering RNAs (siRNAs) for RNA interference (RNAi), are limited due to the difficulty of delivering nucleic acids...Full Text Available

2010-09-01

370

Completely phased genome sequencing through chromosome sorting

Alveolar enlargement, which is characteristic of bronchopulmonary dysplasia, congenital matrix disorders, and cigarette smoke-induced emphysema, is thought to result from enhanced inflammation and ensuing...Full Text Available

2009-07-01

371

Comparative mapping of Andropogoneae: Saccharum L. (sugarcane) and its relation to sorghum and?maize

The two haploid genome sequences that a person inherits from the two parents represent the most fundamentally useful type of genetic information for the study of heritable diseases and the development...Full Text Available

2011-01-04

372

Common mitochondrial polymorphisms as risk factor for endometrial cancer

Comparative genetic maps of Papuan Saccharum officinarum L. (2n = 80) and S. robustum (2n = 80) were constructed by using single-dose...Full Text Available

1997-12-23

373

Common Genetic Variants Associate with Serum Phosphorus Concentration

Endometrial carcinoma is the most commonly diagnosed gynaecological cancer in developed countries. Although the molecular genetics of this disease has been in the focus of many research laboratories...Full Text Available

374

Co-localization of Sorting Nexin 2 and Androgen Receptor in the Song System of Juvenile Zebra Finches

Phosphorus is an essential mineral that maintains cellular energy and mineralizes the skeleton. Because complex actions of ion transporters and regulatory hormones regulate serum phosphorus concentrations,...Full Text Available

2010-07-01

375

Climate Change, Genetics or Human Choice: Why Were the Shells of Mankind's Earliest Ornament Larger in the Pleistocene Than in the Holocene?

Mechanisms regulating sexual differentiation of the zebra finch song system appear to include both genetic and hormonal factors. Sorting Nexin 2 (SNX2), which is involved in trafficking proteins...Full Text Available

2010-07-09

376

Chemical complementation: A reaction-independent genetic assay for enzyme catalysis

BackgroundThe southern African tick shell, Nassarius kraussianus (Dunker, 1846), has been identified as being the earliest known ornamental object used by human...Full Text Available

377

Calcium, Vitamin D, VDR Genotypes, and Epigenetic and Genetic Changes in Rectal Tumors

A high-throughput assay for enzyme activity has been developed that is reaction independent. In this assay, a small-molecule yeast three-hybrid system is used to link enzyme catalysis to transcription...Full Text Available

2002-12-24

378

Biodiversity of Costa Rican salamanders: Implications of high levels of genetic differentiation and phylogeographic structure for species formation

Calcium, vitamin D, exposure to sunshine, and vitamin D receptor (VDR) genotypes have been associated rectal cancer. We used data from 750 rectal tumors and 1,205 population-based...Full Text Available

2010-05-01

379

Behavioral genomics of honeybee foraging and nest defense

Although salamanders are characteristic amphibians in Holarctic temperate habitats, in tropical regions they have diversified evolutionarily only in tropical America. An adaptive radiation centered...Full Text Available

2000-02-15

380

Association of COMT Val^108/158Met Genotype and Cigarette Smoking in Pregnant Women

The honeybee has been the most important insect species for study of social behavior. The recently released draft genomic sequence for the bee will accelerate honeybee behavioral genetics. Although...Full Text Available

2007-04-01

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381

Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.

Introduction:Smoking behaviors, including heaviness of smoking and smoking cessation, are known to be under a degree of genetic influence. The enzyme catechol O-methyltransferase...Full Text Available

2011-02-01

382

Assessment of the bone quality of black male athletes using calcaneal ultrasound: a cross-sectional study

Familial defective apolipoprotein (apo) B-100 is a genetic disease that leads to hypercholesterolemia and to an increased serum concentration of low density lipoproteins that bind defectively to the...Full Text Available

1989-01-01

383

Antidepressant-Like Effects of ?-Opioid Receptor Antagonists in Wistar Kyoto Rats

BackgroundLifestyle, genetics and environmental factors are established determinants of bone density. We aimed to describe the bone characteristics of competitive top-ranked Nigerian...Full Text Available

384

Anticipation in familial lattice corneal dystrophy type I with R124C mutation in the TGFBI (BIGH3) gene

The Wistar Kyoto (WKY) rat strain is a putative genetic model of comorbid depression and anxiety. Previous research showing increased κ-opioid receptor (KOR)...Full Text Available

2010-02-01

385

Angiotensin II Promotes Development of the Renal Microcirculation through AT₁ Receptors

PurposeTo report the clinical, ophthalmic, and genetic characteristics for lattice corneal dystrophy type I (LCDI) in a Chilean family.MethodsSix...Full Text Available

386

Analysis of non-TIR NBS-LRR resistance gene analogs in Musa acuminata Colla: Isolation, RFLP marker development, and physical mapping

Pharmacologic or genetic deletion of components of the renin-angiotensin system leads to postnatal kidney injury, but the roles of these components in kidney development are unknown. To test the hypothesis...Full Text Available

2010-03-01

387

Analysis of genomic differences among Clostridium botulinum type A1 strains

BackgroundMany commercial banana varieties lack sources of resistance to pests and diseases, as a consequence of sterility and narrow genetic background. Fertile wild relatives,...Full Text Available

388

An integrative multi-dimensional genetic and epigenetic strategy to identify aberrant genes and pathways in cancer

BackgroundType A1 Clostridium botulinum strains are a group of Gram-positive, spore-forming anaerobic bacteria that produce a genetically, biochemically, and biophysically...Full Text Available

389

An excess of rare genetic variation in ABCE1 among Yorubans and African-American individuals with HIV-1

BackgroundGenomics has substantially changed our approach to cancer research. Gene expression profiling, for example, has been utilized to delineate subtypes of cancer, and facilitated...Full Text Available

390

An Immune Basis for Malaria Protection by the Sickle Cell Trait

Signatures of natural selection occur throughout the human genome and can be detected at the sequence level. We have re-sequenced ABCE1, a host candidate gene essential for...Full Text Available

2009-12-01

391

Air pollution induces heritable DNA mutations

BackgroundMalaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for over half a century. Nevertheless, the mechanism...Full Text Available

2005-05-01

392

Ageing in Drosophila: The role of the insulin/Igf and TOR signalling network

Hundreds of thousands of people worldwide live or work in close proximity to steel mills. Integrated steel production generates chemical pollution containing compounds that can induce genetic damage...Full Text Available

2002-12-10

393

Activation of cycasin to a mutagen for Saccharomyces cerevisiae by rat intestinal flora.

A remarkable discovery of recent years is that, despite the complexity of ageing, simple genetic interventions can increase lifespan and improve health during ageing in laboratory animals. The pathways...Full Text Available

2011-05-01

394

A study of the genetics of dieldrin-resistance in the housefly (Musca domestica L.)*

Genetic test systems involving microorganisms and liver enzyme preparations may be insufficient to detect compounds that require breakdown by enzymes provided by the microbial flora of the intestinal...Full Text Available

1983-02-01

395

A multi-marker model for detecting chromosomal segments displaying QTL activity

Reciprocal mass crosses and back-crosses were performed between two homogeneous strains of the housefly (Musca domestica L.), representing the extremes in susceptibility and resistance...Full Text Available

1963-01-01

396

A homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, ? cell hyperplasia, and islet cell tumor

A statistical method is presented for detecting quantitative trait loci (QTLs), based on the linear model. Unlike methods able to detect a few well separated QTLs and to estimate their effects and positions, this method considers the genome as a whole and enables the detection of chromosomal segments involved in the differences between two homozygous lines, and their backcross, doubled haploid, or F[sub 2] progenies, for a quantitative trait. Genetic markers must be codominant, but missing markers are accepted, provided they are missing independently from the experiment. Asymptotic properties, which are of practical use, are developed. This method does not rely on strong genetic hypotheses, and thus does not permit any precise genetic analysis of the trait under study, but it does assess which regions of the genome are involved, whatever the complexity of the genetic determinism (number, effects and ...

1993-08-01

397

A haplotype map of the human genome

ObjectiveThe goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic α cell hyperplasia...Full Text Available

2009-11-01

398

A combination of transposable elements and magnetic cell sorting provides a very efficient transgenesis system for chicken primary erythroid progenitors

Inherited genetic variation has a critical but as yet largely uncharacterized role in human disease. Here we report a public database of common variation in the human genome: more than one million...Full Text Available

2005-10-27

399

A Turquoise Mutant Genetically Separates Expression of Genes Encoding Phycoerythrin and Its Associated Linker Peptides

BackgroundStable transgenesis is an undeniable key to understanding any genetic system. Retrovirus-based insertional strategies, which feature several technical challenges when they...Full Text Available

400

A Suppression Subtractive Hybridization Approach Reveals Niche-Specific Genes That May Be Involved in Predator Avoidance in Marine Synechococcus Isolates

During complementary chromatic adaptation (CCA), cyanobacterial light harvesting structures called phycobilisomes are restructured in response to ambient light quality shifts. Transcription of genes...Full Text Available

2002-02-01

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401

A Practical Approach to Genetic Inducible Fate Mapping: A Visual Guide to Mark and Track Cells In Vivo

Picocyanobacteria of the genus Synechococcus are important contributors to marine primary production and are ubiquitous in the world's oceans. This genus is genetically diverse, and...Full Text Available

2006-04-01

402

A DNA transposon-based approach to validate oncogenic mutations in the mouse

Fate maps are generated by marking and tracking cells in vivo to determine how progenitors contribute to specific structures and cell types in developing and adult tissue. An advance in this...Full Text Available

403

29 CFR 2590.702-1 - Additional requirements prohibiting discrimination based on genetic information.

Large-scale cancer genome projects will soon be able to sequence many cancer genomes to comprehensively identify genetic changes in human cancer. Genome-wide association studies have also identified...Full Text Available

2008-12-16

404

Stochastic Optimization Approaches for Solving Sudoku

...treated for leukemia. B' s physician, who is employed by the HMO, is considering a treatment plan that includes six-mercaptopurine, a drug for treating leukemia in most children. However, the drug could be fatal if taken by a small percentage of...

2010-07-01

405

Optimal Parameter Selection of Power System Stabilizer using Genetic Algorithm

In this paper the Sudoku problem is solved using stochastic search techniques and these are: Cultural Genetic Algorithm (CGA), Repulsive Particle Swarm Optimization (RPSO), Quantum Simulated Annealing (QSA) and the Hybrid method that combines Genetic Algorithm with Simulated Annealing (HGASA). The results obtained show that the CGA, QSA and HGASA are able to solve the Sudoku puzzle with CGA finding a solution in 28 seconds, while QSA finding a solution in 65 seconds and HGASA in 1.447 seconds. This is mainly because HGASA combines the parallel searching of GA with the flexibility of SA. The RPSO was found to be unable to solve the puzzle.

2008-01-01

406

Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent

In this paper, it is suggested that the selection method of optimal parameter of power system stabilizer (PSS) with robustness in low frequency oscillation for power system using real variable elitism genetic algorithm (RVEGA). The optimal parameters were selected in the case of power system stabilizer with one lead compensator, and two lead compensator. Also, the frequency responses characteristics of PSS, the system eigenvalues criterion and the dynamic characteristics were considered in the normal load and the heavy load, which proved usefulness of RVEGA compare with Yu's compensator design theory. (author). 20 refs., 15 figs., 8 tabs.

1999-06-01

407

Estimated values of the genetic and somatic radiation exposure of the Bulgarian population in 1976

Gaussian-process models are developed to detect genetic linkage using complete high-resolution maps of identity by descent between affected relative pairs. Approximations are given for the significance level and power of the likelihood-ratio test of no linkage and for likelihood-ratio confidence regions for trait loci. The sample sizes required to detect linkage by using different classes of affected relative pairs are compared, and the problem of combining data from different classes of relatives is discussed. 23 refs., 2 figs.

1993-07-01

408

Characterization of eight microsatellite markers in the white sea bream, Diplodus sargus (Teleostei, Sparidae)

The genetically and leukemia-significant doses (GSD and LSD) were calculated from the average gonad and bone marrow doses caused by the most frequently applied radiopharmaceuticals in Bulgaria in 1976. Because of the lack of information about the age groups of the patients examined assumptions have been made which led to estimated values of 0.97 mrad for GSD and 2.0 mrad for LSD which must be considered as the upper limit of the real GSD and LSD. The influence of the different radiopharmaceuticals on the average radiation exposure of the population is discussed. (author).

1976-01-01

409

British Library Electronic Table of Contents (United Kingdom)

Abstract The white sea bream, Diplodus sargus (Teleostei, Sparidae), is a species with a high commercial importance in Mediterranean aquaculture. There is currently little information available about the genetic characteristics of cultured populations. In this survey, we have developed eight polymorphic microsatellites for the white sea bream using an enriched genome library protocol. All of them were polymorphic in the 67 individuals tested, 32 of which were wild specimens, and 35 were individuals from a captive F1 broodstock. These markers can potentially be useful tools for use in population genetic studies.

2008-01-01

410

An improved colony PCR procedure for genetic screening of Chlorella and related microalgae.

Algorithm for assessment of mean annual gonad dose and genetically significant dose from the data of personal dosimetry

A colony PCR technique was applied for both genomic and chloroplast DNA in the green microalgae Chlorella. Of five different lysis buffers, Chelex-100 was superior for DNA extraction, PCR and DNA storage. It also was insensitive to variations in cell density. The conditions established for an improved PCR formulation are applicable for screening of genetically-engineered transformants as well as bioprospecting of natural microalgal isolates. Besides multiple Chlorella species, we also demonstrate the efficacy of Chelex-100 for colony PCR with a number of other microalgal strains, including Chlamydomonas reinhardtii, Dunaliella salina, Nannochloropsis sp., Coccomyxa sp., and Thalassiosira pseudonana. PMID:21431847

2011-03-24

411

Genetic and physical location of the gene for Stargardt`s disease and further evidence for genetic homogeneity

During one year more than 40,000 items of information on radiation exposure of personnel involved in the handling of radiation sources and more than 5,000,000 items on irradiation of other people are collected in the authors' laboratory. Considerable progress in assessment of mean annual gonad dose of genetically sifnificant dose was attained by means of an algorithm for a personal computer. This simple and inexpensive system has led to a higher accuracy in the application of protective measures. (author).

1985-10-22

412

The spoIIE homolog of Epulopiscium sp. type B is expressed early in intracellular offspring development.

Stargardt`s disease is inherited as an autosomal recessive condition characterized by a juvenile macular dystrophy. Genetic linkage analysis recently assigned the disease locus to chromosome 1p21-p13 with the best estimate for location of the gene near the locus D1S435. We performed linkage analysis in 34 North American families and 2 inbred families from the Kingdom of Saudi Arabia with 12 highly polymorphic markers on chromosome 1p flanking D1S435 between D1S207 and D1S223 and report significant linkage for all 12 markers with no evidence for genetic heterogeneity. Two-point linkage analysis demonstrated the Stargardt`s disease locus and D1S435 are linked with a maximum lod score of 17.17 at a recombination fraction of 1%. The markers UT851, D1S188, D1S424, UT2069, and D1S236 also demonstrated recombination fractions of 1% or less with two-point lod scores of 15.86, 21.93, 16.41, 20.36, and 17.37, respectively. To characterize this region ...

1994-09-01

413

The role of networking for nuclear education

Epulopiscium sp. type B is an enormous intestinal symbiont of the surgeonfish Naso tonganus. Intracellular offspring production in Epulopiscium shares features with endospore formation. Here, we characterize the spoIIE homolog in Epulopiscium. The timing of spoIIE gene expression and presence of interacting partners suggest that the activation of ?(F) occurs early in Epulopiscium offspring development. PMID:21398534

2011-03-11

414

The Protein Kinase SnRK2.6 Mediates the Regulation of Sucrose Metabolism and Plant Growth in Arabidopsis^[W]^[OA]

Nuclear knowledge is the basis for almost all nuclear activities, and education and training are the most fundamental means to transfer knowledge from one generation to the next. Understanding means and trends in knowledge transfer through education and training thus deserves a closer examination. In the past years, a number of trends and questions in nuclear knowledge, education and training have emerged. With declining student enrolment numbers and a general stagnation of the use of nuclear power in some of the IAEA's Member States, the issue of a slow erosion of the knowledge base and the possibility of loosing knowledge has become increasingly important, in particular if seen against the background of a possible renaissance of nuclear power in the future. In other Member States, an expansion of nuclear power is expected, with a corresponding need for human resources. As a result, in many Member States education and training of the next generation and succession planning have become ...

2004-10-01

415

Synthesis and crystal structure of a new open-framework iron phosphate (NH4)4Fe3(OH)2F2[H3(PO4)4]: Novel linear trimer of corner-sharing Fe(III) octahedra

In higher plants, three subfamilies of sucrose nonfermenting-1 (Snf1)-related protein kinases have evolved. While the Snf1-related protein kinase 1 (SnRK1) subfamily has been shown to share pivotal...Full Text Available

2010-05-01

416

Remote participation technical infrastructure for the JET facilities under EFDA

A new iron phosphate (NH4)4Fe3(OH)2F2[H3(PO4)4] has been synthesized hydrothermally at HF concentrations from 0.5 to 1.2 mL. Single-crystal X-ray diffraction analysis reveals its three-dimensional open-framework structure (monoclinic, space group P21/n (No. 14), a=6.2614(13) A, b=9.844(2) A, c=14.271(3) A, ?=92.11(1)o, V=879.0(3) A3). This structure is built from isolated linear trimers of corner-sharing Fe(III) octahedra, which are linked by (PO4) groups to form ten-membered-ring channels along [1 0 0]. This isolated, linear trimer of corner-sharing Fe(III) octahedra, [(FeO4)3(OH)2F2], is new and adds to the diverse linkages of Fe polyhedra as secondary building units in iron phosphates. The trivalent iron at octahedral sites for the title compound has been confirmed by synchrotron Fe K-edge XANES spectra and magnetic measurements. Magnetic measurements also show that this compound exhibit a strong antiferromagnetic exchange below TN=17 K, ...

2010-12-01

417

Large T1 oligonucleotides of Moloney leukemia virus missing in an env gene recombinant, HIX, are present on an intracellular 21S Moloney viral RNA species.

The new collaborative exploitation of the JET Facilities requires suitable technical tools and infrastructure measures to enable the Remote Participation of scientists from all European Fusion labs. Such measures are being gradually introduced. They comprise of a toolkit for Remote Data Access, Remote Computer Access and for teleconferencing, and of infrastructure measures that address network connectivity, network security, shared documentation and technical support.

2001-10-01

418

Kes1p shares homology with human oxysterol binding protein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis.

HIX, a recombinant derived from Moloney leukemia virus, has an envelope glycoprotein different from that of the Moloney virus. HIX and Moloney viruses share the majority of the large T1 oligonucleotides...Full Text Available

1978-06-01

419

Genome-wide association studies of gastric adenocarcinoma and esophageal squamous cell carcinoma identify a shared susceptibility locus in PLCE1 at 10q23

The yeast phosphatidylinositol transfer protein (Sec14p) is required for biogenesis of Golgi-derived transport vesicles and cell viability, and this essential Sec14p requirement is abrogated by inactivation...Full Text Available

1996-12-02

420

Genome-Wide Association Study SNPs in the Human Genome Diversity Project Populations: Does Selection Affect Unlinked SNPs with Shared Trait Associations?

We conducted a genome-wide association study of gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 single nucleotide polymorphisms...Full Text Available

2010-09-01

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421

Experimental realization of Dicke states of up to six qubits for multiparty quantum networking

Genome-wide association studies (GWAS) have identified more than 2,000 trait-SNP associations, and the number continues to increase. GWAS have focused on traits with potential consequences for human...Full Text Available

2011-01-01

422

Entangling optical and microwave cavity modes by means of a nanomechanical resonator

We report the first experimental generation and characterization of a six-photon Dicke state and demonstrate its remarkable versatility by projecting out four- and five-photon Dicke states, in addition to four-photon GHZ- and W-states. These multipartite states are studied by developing experimentally favorable characterization tools. Furthermore, we show that Dicke states have interesting applications in multiparty quantum networking protocols such as open-destination teleportation, telecloning and quantum secret sharing.

2009-01-01

423

Distributed multiprocessor system runs on 68000-based VME bus hardware

We propose a scheme able to generate stationary continuous variable entanglement between an optical and a microwave cavity mode by means of their common interaction with a micro-mechanical resonator. We show that when both cavities are intensely driven one can generate bipartite entanglement between any pair of the tripartite system, and that, due to entanglement sharing, optical-microwave entanglement is efficiently generated at the expense of microwave-mechanical and opto-mechanical entanglement.

2011-01-01

424

Direct conversion of fusion energy into the electric one in the 'Dragon' magnetic confinement system

Using the Philips DRM distributed real-time multiprocessing system, designers can implement high-performance computer systems using VME hardware and the C programming language. The system provides a virtual-processing environment in which several 68000 CPUs share the workload. There are no centralized components, and tasks can be assumed by the rest of a system in the event of an individual processor's failure.

1984-04-19

425

Differential decay of parent-of-origin-specific genomic sharing in cystic fibrosis-affected sib pairs maps a paternally imprinted locus to 7q34

It is shown that recuperator in which the thermal energy of particles is transformed into electric oue under drift in crossed fields is naturally coupled with dragontype magnetic confinement system, so the recuperation process can be initiated in the dragon magnetic field. A number of questions occuring under analysis of recuperator-dragon system is considered, including the dynamics of particle transfer to the recuperator, the share of particles entering the recuperator, the effect of rotational transform and the recuperation efficiency.

426

Conservation and renewable energy programs: Technical and financial assistance

Cystic fibrosis (CF) is a monogenic disease characterized by a high variability of disease severity and outcome that points to the role of environmental factors and modulating genes that shape the course...Full Text Available

2010-05-01

427

Combined cycles and combined energy systems for a safe and sound environment and life

The US Department of Energy, Office of Technical and Financial Assistance (OTFA) promotes the application of renewable energy and energy efficiency technologies and practices by working cooperatively with state and local governments and private and nonprofit organizations, providing technical and financial assistance and serving as network for sharing information. This report is an overview of some of the programs designed to aid in solving our national energy problems.

1991-05-01

428

Ceramic dome receiver technology developments

Discussion is presented of world CO{sub 2} emissions and the effect rising population and population distribution has on this. Possible ways of decreasing emissions are presented, including potential for heat recovery, exhaust-air purification as an energy supply, shared power supply in industry, the use of cogeneration, and multiple use of heat in industry. 9 refs., 10 figs., 3 tabs.

1992-01-01

429

Business perspective for information technology

The development and experimental demonstration of a high-temperature seal for the SHARE ceramic dome cavity receiver is reported. The mechanical contact seal which was tested on one-foot-diameter silicon-carbide ceramic-dome hardware at pressure differentials to four atmospheres and dome temperatures to 2200/sup 0/F (1200/sup 0/C) showed negligible leakage at expected receiver operating conditions. Potential solar receiver applications for the technology are illustrated.

1980-01-01

430

Astrocytes derived from trisomic human embryonic stem cells express markers of astrocytic cancer cells and premalignant stem-like progenitors

Increasingly, utility organizations recognize the value of sharing data and applications among their computing environments. A typical utility`s computing environment may consist of disparate computer platforms. The focus of this paper is to highlight importance of a documented information technology architecture for identifying business perspectives for interoperability, and to brief utility management about the Electric Power Research Institute`s (EPRI) accomplishment along these same lines.

1995-10-01

431

Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.

BackgroundTrisomic variants of human embryonic stem cells (hESCs) arise spontaneously in culture. Although trisomic hESCs share many properties with diploid hESCs, they also exhibit...Full Text Available

432

A calculation program for electricity generation costs using LOTUS

A series of translocation break points found in a subset of human acute leukemias have one of the breaks on human chromosome 11q23. This region has recently been cloned and a large gene, ALL-1, with...Full Text Available

1993-07-01

433

Self-expanding nitinol stents for treatment of infragenicular arteries following unsuccessful balloon angioplasty

This program is designed in order to calculate electricity generation cost by different energy sources, and menu type is adopted for user convenience. This program also graphically shows the share of capital investment cost, O and M cost, and fuel cost. Sensitivity analysis about discount rate can also be carried out by this program, taking into consideration the important role of the discount rate in the generation costs calculation. (Author) 7 refs., 1 fig., 3 tabs.

1994-12-01

434

Radiologic findings of extraosseous Ewing's sarcoma

The feasibility of self-expanding nitinol stents for treatment of infragenicular arteries following unsuccessful balloon angioplasty was assessed. Options for lower limb percutaneous revascularization are limited, especially for complex vessel obstruction. Depending on the lesion and the experience of the interventionalist, the failure rate of balloon angioplasty (PTA) ranges between 10 and 40%. Until recently, no self-expanding stent for the use in the infragenicular arteries was available. This is the first report of the results for 18 consecutive patients who received 4F sheath compatible self-expanding nitinol stents following unsuccessful PTA or early restenosis. Twenty-four stents were implanted in 21 lesions for various indications residual stenosis >50% due to heavy calcification, flow-limiting dissection, occluding thrombus resistant to thrombolyis, thrombaspiration, and PTA, and early restenosis after previous PTA. Stent implantation was feasible ...

2007-08-15

435

Intrahepatic peripheral cholangiocarcinoma; dynamic features of CT scans

The purpose of this study is to evaluate the radiologic findings of the extraosseous Ewing's sarcoma. Six patients with pathologically confirmed extraosseous Ewing's sarcoma were retrospectively reviewed. Patients included two men and four women with an average age of 21.5 years (age range 9-48 years). Plain radiographs (six patients), magnetic resonance (MR) images (five patients), computed tomographic (CT) scans (three patients) and whole body scintigraphy (two patients) were reviewed and analyzed. Images were evaluated with regard to lesion location, size, margin, muscle or bone involvement and intrinsic imaging characteristics on CT and MRI. The tumors were located in the thigh (three patients), back (two patients) and upper arm (one patient). The tumors ranged in size from 2.3 cm to 7.5 cm (mean, 5.2 cm), were mainly well circumscribed and showed no evidence of calcification prior to treatment. Margins were well defined in four out of the six patients. Four ...

2005-09-01

436

High-field MR imaging in the follow-up of patients with valvular and composite tubular aortic prostheses

To elucidate the dynamic features of CT scans in peripheral cholangiocarcinoma for the differentiation of this tumor from various primary hepatic neoplasms. Materials were 24 cases of pathologically confirmed peripheral cholangiocarcinoma. Contrast enhancement patterns of central and peripheral portion of the masses were analyzed at three phases including arterial dominant(22), tissue equilibria(24), and postequilibria(9). Other associated CT findings and laboratory data were analyzed. Serum total bilirubin was mostly below 2 mg/dl(22/24), hepatitis B surface antigen was positive in only 9%, serum alphafetoprotein was elevated in 18%, carcinoembryonic antigen in 47%, cancer antigen 19-9 in 60%. In the arterial dominant image(22), 50% of the cases showed peripheral hyperdensity and 50% total hypodensity. In the tissue equilibrial images(24), 63% showed total hypodensity, 25% peripheral hyperdensity, and 13% total isodensity. In the postequilibrial images(9), 45% showed peripheral ...

1995-05-01

437

Disorders of brain development and phakomatosis

Eleven patients who had undergone cardiac surgery were studied by means of high-field MR imaging (1.5 T). Six patients had aortic root and valve replaced with a Bjork-Shiley (BS) composite tubular aortic graft prosthesis for acute dissection of ascending aorta. In the other 5 patients with rheumatic calcific aortic disease, the valve had been replaced with a BS prosthesis. As a whole, MR studies were 14. Previous evaluations of magnetic field effects had seem carried out ex vivo on both BS valves and BS composite prostheses, on surgical ligation clips (Tantalium and Stainless) and on stainless wires for sternal closure. In 4 patients (2 BS composite grafts, and 2 BS valves) MRI diagnosed chronic dissection of both arch and descending aorta. In 1 of them, with a bs valve, associated localized acute dissection of ascending aorta was observed. In 3 patients with BS composite grafts, MRI revealed pseudo-aneurysms (including a thrombosed one) at the graft level. In one ...

438

The somatically significant dose, SSD, and analog of the GSD, the genetically significant dose

Full text: Disorders of brain development and phakomatosis are resulting from disturbed embryonic-foetal development One third of all major embryological anomalies involve CNS, and over 2000 different anomalies have been described. Anomalies of the brain often cause foetal and neonatal death, and mental and physical retardation in pediatric group. The majority of disorders of brain development and phakomatosis are idiopathic, and most of them are not hereditary or familial. Ultrasonography plays the important role in screening foetal and neonatal brain, but after closure of fontanels it is difficult to find the acoustic window. CT has limited contrast resolution, and disadvantage exposing infant to ionizing radiation. It is helpful to demonstrate the presence of calcifications. MR imaging has proved to be a diagnostic tool of major importance in children with disorders of brain development and phakomatosis. The excellent grey/white matter differentiation and ...

439

On the genetic and somatic radiation doses in radiotherapy of inflammatory and degenerative diseases of bones, joints and soft parts

The medical applications of radiation comprise three main fields namely: Diagnostic Radiology, Radiotherapy and Nuclear Medicine. With the new weighting factors of ICRP (IC91a) the effective dose due to medical applications can be established. I is common to separate the effective dose into the genetic part and the somatic part, SED. In dealing with gonad doses it is important to account for the age of the person at the time of exposure as this will influence the number of children still to be expected from that person. The resulting dose will then be called the genetically significant dose, GSD. In a similar fashion this age factor will be important in considering the chance of tumor induction. The age of patients differs considerably from the average age of the general population. This age difference has to be accounted for if a comparison is to be made with other sources of radiation. This justifies establishing a somatically significant ...

1991-11-01

440

Molecular epidemiology of childhood leukemia with emphasis on chemical exposures

Dose measurements were performed in several body regions of patients suffering from inflammatory degenerative diseases (humeral epicondylitis, humeroscapular periarthritis, gonarthrosis, axillary hidradenitis, rheumatoid arthritis, coxarthrosis, parotitis). The problem of the radiation induction of neoplasms is predominant concerning somatic as well as genetic risk, discussed by example of the most frequently occurring organ cancer. Compared to the rate of breast cancer in the highly developed industrial states (5,000 to 6,000 cancers/100,000 women) the 'radiation induction' calculated according to a mathematical model of ICRP 26 (1.25 cases of death for breast cancers/100,000 women following for example irradiation of epicondylitis) is behind several powers of ten and not demonstrable. The genetic radiation exposure is also low. Derived from the measurements it is wrong to give up reliable and approved indications of radiotherapy of ...

1983-01-01

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441

Human cDNA mapping using fluorescence in situ hybridization. Progress report, April 1, 1992--December 31, 1992

Developing markets in the Pacific Basin depend heavily on the production and export of consumer goods. The generation of hazardous waste as a by-product of industrial production can be linked to adverse health outcomes, such as childhood leukemia, in ways that are presently unknown. In California, exposures resulting from hazardous waste disposal are of concern in the etiology of childhood cancer. Approximately 63% of the 57 hazardous waste sites that the U.S. Environmental Protection Agency (USEPA) included in the national priority list under the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA) statute were in the six-county San Francisco Bay area. This area includes California`s Silicon Valley, where a disproportionate majority of these sites are located. Although only one study links hazardous waste disposal to childhood leukemia evidence is accumulating that in utero and maternal pesticide exposures as well as chemical exposures during childhood are ...

1996-12-31

442

High genetic diversity of HIV-1 was found in men who have sex with men in Shijiazhuang, China

Genetic mapping is approached using the techniques of high resolution fluorescence in situ hybridization (FISH). This technology and the results of its application are designed to rapidly generate whole genome as tool box of expressed sequence to speed the identification of human disease genes. The results of this study are intended to dovetail with and to link the results of existing technologies for creating backbone YAC and genetic maps. In the first eight months, this approach generated 60--80% of the expressed sequence map, the remainder expected to be derived through more long-term, labor-intensive, regional chromosomal gene searches or sequencing. The laboratory has made significant progress in the set-up phase, in mapping fetal and adult brain and other cDNAs, in testing a model system for directly linking genetic and physical maps using FISH with small fragments, in setting up a database, and in establishing the ...

1993-03-04

443

British Library Electronic Table of Contents (United Kingdom)

Men who have sex with men (MSM) have become one of the populations with severely HIV prevalence in China. However, very few genetic studies have been done on HIV-1 spreading in this population. In this study, the genetic characterization of HIV-1 strains prevalent in the MSM in Shijiazhuang, China, was analyzed basing on the HIV-1 full-length gag, pol, and partial env gene. 21 drug-naive HIV-1 sero-positive patients were enrolled into the study. Full length gag, pol, partial env genes and some near full length genomes were amplified with nest RT-PCR followed by sequencing. Multiple subtypes, including CRF01_AE (52.9%), subtype B (35.3%) and CRF07_BC (11.8%), were found in the population. Phylogenetic analysis showed close relationship between our strains with those from Beijing MSM but not...

2011-01-01

444

Effective per-capita dose as a yardstick for medical radiation exposure of the population - a supplement or an alternative to the genetically significant dose

Absence of linkage of apparently single gene mediated ADHD with the human syntenic region of the mouse mutant coloboma

The genetically significant dose (GSD) is an index variable which exclusively allows to describe the genetic risk in the progeny of a population due to the application of ionizing radiation and radioactive substances in one part of this population. It may result in wrong interpretation of population exposure at increasing incidence of examinations in a population involving ionizing radiation and radioactive drugs at simultaneously increasing application of alternative methods in children and adolescents owing to the fact that it indicates a downward trend although somatic exposure of this population has increased. Therefore, it is recommended to state both the GSD and the level of somatic radiation exposure of the population taken from the individual sources for the comparison and assessment of radiation exposure from various sources in future. Although the somatically significant dose constitutes the suitable variable complementary to GSD in ...

1984-06-01

445

Genetic Modification of Short Rotation Poplar Biomass Feedstock for Efficient Conversion to Ethanol

Attention deficit disorder (ADHD) is a complex biobehavioral phenotype which affects up to 8% of the general population and often impairs social, academic, and job performance. Its origins are heterogeneous, but a significant genetic component is suggested by family and twin studies. The murine strain, coloboma, displays a spontaneously hyperactive phenotype that is responsive to dextroamphetamine and has been proposed as a genetic model for ADHD. Coloboma is a semi-dominant mutation that is caused by a hemizygous deletion of the SNAP-25 and other genes on mouse chromosome 2q. To test the possibility that the human homolog of the mouse coloboma gene(s) could be responsible for ADHD, we have carried out linkage studies with polymorphic markers in the region syntenic to coloboma (20p11-p12). Five families in which the pattern of inheritance of ADHD appears to be autosomal dominant were studied. Segregation analysis of the traits studied suggested ...

1995-12-18

446

Use of a trap garden to find additional genetically distinct isolates of the rust fungus Phragmidium violaceum to enhance biological control of European blackberry in Australia

The Bioenergy Feedstock Development Program, Environmental Sciences Division, Oak Ridge National Laboratory is developing poplars (Populus species and hybrids) as sources of renewable energy, i.e., ethanol. Notable increases in adaptability, volume productivity, and pest/stress resistance have been achieved via classical selection and breeding and intensified cultural practices. Significant advances have also been made in the efficiencies of harvesting and handling systems. Given these and anticipated accomplishments, program leaders are considering shifting some attention to genetically modifying feedstock physical and chemical properties, so as to improve the efficiency with which feedstocks can be converted to ethanol. This report provides an in-depth review and synthesis of opportunities for and feasibilities of genetically modifying feedstock qualities via classical selection and breeding, marker-aided selection and breeding, and ...

2000-08-30

447

British Library Electronic Table of Contents (United Kingdom)

Biological control agents can be more effective if their populations are genetically diverse, particularly when the target invasive plant comprises a range of genotypes with different susceptibilities and occurs across various microclimates. We report on the use of an efficient approach to find, in the native range, diverse isolates of a rust fungus for biological control. An outdoor trap garden containing various clones of invasive European blackberry (Rubus fruticosus agg.) collected in Australia, each with a different DNA phenotype, was established in France. Within 4?weeks of establishment, the leaf-rust fungus Phragmidium violaceum was recovered from all clones in the garden. Molecular analyses of eight recovered and purified isolates of the fungus from the garden revealed that they w...

2011-01-01

448

Two-photon calcium imaging from head-fixed Drosophila during optomotor walking behavior

British Library Electronic Table of Contents (United Kingdom)

Drosophila melanogaster is a model organism rich in genetic tools to manipulate and identify neural circuits involved in specific behaviors. Here we present a technique for two-photon calcium imaging in the central brain of head-fixed Drosophila walking on an air-supported ball. The ball's motion is tracked at high resolution and can be treated as a proxy for the fly's own movements. We used the genetically encoded calcium sensor, GCaMP3.0, to record from important elements of the motion-processing pathway, the horizontal-system lobula plate tangential cells (LPTCs) in the fly optic lobe. We presented motion stimuli to the tethered fly and found that calcium transients in horizontal-system neurons correlated with robust optomotor behavior during walking. Our technique allows both behavior ...

2010-01-01

449

The effective per caput dose equivalent as a measure of medical radiation exposure of the population - a complement or an alternative to the genetically significant dose

Subjective effects to cannabis are associated with use, abuse and dependence after adjusting for genetic and environmental influences

The GSD must be considered as a quantity by means of which the risk in a given population can be described exclusively in terms of genetic risk. In cases of a simultaneous increase in the rate of examinations, the GSD may lead to a misinterpretation of the population exposure, suggesting a decreasing trend, although there is an actual increase in the somatic radiation exposure. It is recommended to indicate not only the GSD but also the amount of somatic radiation exposure of the population for each specific source when comparing and evaluating radiation exposures from different sources. Although the somatically significant dose formally would be suited as a complement to the GSD, it is recommended to use the effective per caput dose equivalent. It must be pointed out that the application of the concept of effective dose equivalent is only appropriate for comparative evaluations of the population exposure to different sources of radiation. (orig./HP).

1984-01-01

450

British Library Electronic Table of Contents (United Kingdom)

Background Previous reports in adults have suggested that the effects experienced after cannabis use can be described in terms of positive and negative subtypes that are heritable and are associated with abuse and dependence. This study extends existing research by inclusion of adolescents and young adults in an offspring of twins design which makes it possible to take into account genetic and environmental risks for substance use disorder. Methods Data were collected from 725 twin members of the Vietnam Era Twin Registry, 839 of their 12-32 year old biological offspring and 427 mothers. Offspring who had ever used cannabis (n=464) were asked the degree to which they typically experienced 13 subjective effects shortly after using cannabis. Latent class analysis (LCA) was used to derive sub...

2009-01-01

451

Somatic radiation risk in different mammography techniques

Somatic and genetic radiation exposure of the patient in digital subtraction angiography (DSA)

By measuring organ doses with TLD at an Alderson-Rando-phantom it was tested to evaluate the somatic risk for mammographies. Similarly as the genetic risk can be expressed by the genetic significant dose, the somatic risk can be expressed by the somatic significant dose index. The measurement results of the mammography show a large deviation of almost one power of ten with dependence of the chosen technique. In conventional xeroradiography and recording technique with foilless film the somatic radiation risk is the highest. By using amplifying foils in combination with high-sensitive films it is relatively small. Unfortunately the magnitude of the somatic risk in the different mammography techniques is in the ratio reciprocal to the corresponding image quality. At the time being the most favourable technique is mammography with a soft rastering method, although the xeromammography with additional high aluminium-filtering is a further ...

1981-01-01

452

Sequences of versatile, broad-host-range vectors of the RK2 family.

The somatic and genetic radiation exposure of patients undergoing Digital Subtraction Angiography (DSA) and traditional Film Arteriography (FA) of cranial, cervical, thoracic and abdominal vascular territories are compared. The radiation doses absorbed within the critical organs - red bone marrow, lung, thyroid gland and female breast - and in the gonads were measured using an anthropomorphic Alderson phantom. A Somatic Dose Index was calculated in order to estimate the somatic radiation risk. The somatic radiation exposure depends upon the location of the critical organs with respect to the entrance site of the x-ray beam, and can be reduced by an appropriate choice of the angiographic projection. Under this condition, the radiation exposure of the patient during DSA can be lower than during FA. For renal DSA an a.p. projection, the use of an abdominal compression device and careful caudal shielding of the field are advocated. (orig.).

1986-01-01

453

Risk assessment for radiation protection purposes

Plasmid pRK404-a smaller derivative of RK2-is a tetracycline-resistant broad-host-range vector that carries a multiple cloning site and the lacZ(alpha) peptide that enables blue/white selection for cloned inserts in Escherichia coli. We present herein the complete and annotated sequence of pRK404 and three related vectors-pRK437, pRK442, and pRK442(H). These derivatives have proven to be valuable tools for genetic manipulation in Gram-negative bacteria. The knowledge of their complete sequences will facilitate efficient future engineering of them and will enhance their general applicability to the design of genetic systems for use in organisms for which new genomic sequence data are becoming available.

2003-07-01

454

Review on the immunology of European sea bass Dicentrarchus labrax

In defining criteria for good protection against ionizing radiation, it is important to assess quantitatively the likely risk of any radiation exposure. The 'somatic' risks to the individual result mainly from induction of cancer in the organs irradiated, and these risks can now be estimated on the basis of numerous detailed epidemiological surveys of exposed human populations. Estimates of the risk of hereditary effects, from genetic changes induced in germ cells, are based largely on the frequency with which such effects are induced in other species. In both cases the risk at very low dose can be inferred using knowledge of the way in which radiation damage is caused in tissues. Coherent systems of radiation protection are based on a restriction of doses to the whole body and to individual organs, such that the induction of cancer and genetic harm is infrequent, and the threshold dose for causing other, 'non-stochastic', effects is not ...

1980-01-01

455

British Library Electronic Table of Contents (United Kingdom)

European sea bass (Dicentrarchus labrax L.) is a marine species of great economic importance, particularly in Mediterranean aquaculture. However, numerous pathogenic viruses, bacteria, fungi and parasites affect the species, causing various infectious diseases and thereby leading to the most heavy losses in aquaculture production of sea bass. In this respect, knowledge on molecular and genetic mechanisms of resistance to pathogens and specific features of immune response against various infectious agents should greatly benefit the development of effective vaccines and proper vaccination strategies in marker-assisted selection of fish resistant to a range of infections. To date, genetic knowledge on sea bass immune regulatory genes responsible for resistance to pathogens is relatively poor ...

2007-01-01

456

Phylogeography of rabies virus isolated from dogs in Brazil between 1985 and 2006

British Library Electronic Table of Contents (United Kingdom)

To establish the phylogeographic relationships in rabies viruses in Brazil, we studied a dataset retrieved from GenBank consisting of 71 genetic sequences from the coding region of the N gene of rabies viruses isolated in dogs over a period of 22?years. The Bayesian Markov chain Monte Carlo method available in the BEAST package was used with the GTR+G+?4 evolutionary model in conjunction with the relaxed uncorrelated lognormal molecular clock model and an exponential growth tree prior. A discrete phylogeographic diffusion model was also analyzed using a standard continuous-time Markov chain viewed with Google Earth to provide a spatial projection of the diffusion of genetic lineages based on their phylogeographic relationships. The topology of the time and substitution phylogenetic trees a...

2011-01-01

457

Novel Techniques and Their Wide Applications to Health Foods, Medical and Agricultural Biotechnology in Relation to Policy Making on Genetically Modified Crops and Foods

Mucosal Inflammation in Spondylarthritides: Past, Present, and Future

Selected applications of novel techniques in Agricultural Biotechnology, Health Food formulations and Medical Biotechnology are being reviewed with the aim of unraveling future developments and policy changes that are likely to open new markets for Biotechnology and prevent the shrinking or closing of existing ones. Amongst the selected novel techniques with applications in both Agricultural and Medical Biotechnology are: immobilized bacterial cells and enzymes, microencapsulation and liposome production, genetic manipulation of microorganisms, development of novel vaccines from plants, epigenomics of mammalian cells and organisms, and biocomputational tools for molecular modeling related to disease and Bioinformatics. Both fundamental and applied aspects of the emerging new techniques are being discussed in relation to their anticipated, marked impact on future markets and present policy changes that are needed for success in either Agricultural or Medical ...

2004-01-01

458

British Library Electronic Table of Contents (United Kingdom)

Spondylarthritides (SpA) and inflammatory bowel disease (IBD) are idiopathic, chronic inflammatory disorders. Although they are very distinct and well-defined entities, there is clinical and genetic evidence supporting some degree of overlap between the pathogenesis of the two. Subclinical gut inflammation is present in up to two thirds of all SpA patients and can evolve into IBD. This subclinical gut inflammation has been shown to be strongly associated with joint inflammation, providing a clue for a common pathophysiologic background. Despite extensive research progress in the field over the past few years, many questions remain unanswered. In this paper, we focus on the clinical, genetic, and pathophysiologic overlap of SpA and IBD. Furthermore, we discuss some of the targets that may i...

2011-01-01

459

Mary Lyon and the hypothesis of random X chromosome inactivation

British Library Electronic Table of Contents (United Kingdom)

The 50th anniversary of Mary Lyon?s 1961 Nature paper, proposing random inactivation in early embryonic life of one of the two X chromosomes in the cells of mammalian females, provides an opportunity to remember and celebrate the work of those involved. While the hypothesis was initially put forward by Lyon based on findings in the mouse, it was founded on earlier studies, notably the work of Susumu Ohno; it was also suggested independently by Beutler and colleagues using experimental evidence from a human X-linked disorder, glucose-6-phosphate dehydrogenase deficiency, and has proved to be of as great importance for human and medical genetics as it has for general mammalian genetics. Alongside the hypothesis itself, previous cytological studies of mouse and human chromosomes, and the obse...

2011-01-01

460

Isolation and characterization of microsatellite markers in Acca sellowiana (Berg) Burret.

Introduction to the Special Issue: Human Linkage Studies for Behavioral Traits

Acca sellowiana has commercial potential because of the quality and the unique flavor of its fruit. Conservation of natural populations and management of breeding programmes would benefit from the availability of molecular markers that could be used to characterize levels and distribution of genetic variability. Thus, 13 microsatellite markers were developed from an enriched genomic library of A. sellowiana. They were characterized using 40 samples. The expected and observed heterozygosities ranged from 0.513 to 0.913 and from 0.200 to 0.889, respectively. These are the first microsatellite loci characterized from A. sellowiana that will contribute to improve researches on the genetic conservation, characterization and breeding. PMID:21586063

2008-07-08

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461

British Library Electronic Table of Contents (United Kingdom)

In the post Genome era, the aim of behavior genetics has shifted from estimating the relative contributions of genes and environmental factors to (co-)variation in human complex traits, to localization of genes and identification of functional genetic variants. This special issue reflects this transition and presents fifteen papers that report on genome-wide linkage scans for complex traits in humans and on methodological tools and innovations. Six papers focus on cognition and report overlapping linkage peaks on chromosomes 6p and 14p. Papers on addictive behavior, i.e. smoking and alcohol dependence and its endophenotypes, find moderate LOD scores on chromosomes 6p, 5q, 4p and 7q, respectively. Three papers concentrate on emotionality, depression and loneliness and examine chromosomes 2q...

2006-01-01

462

Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): Localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7

Health risks arising from ionizing radiation and chemical pollutants

The gene encoding the human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R1) was mapped to chromosome 7 by PCR analysis of genomic DNA from a human/rodent somatic cell hybrid mapping panel. This assignment was confirmed and the gene localized to chromosome band 7p14 by fluorescence in situ hybridization. A yeast artificial chromosome containing ADCYAP1R1 was identified in the CEPH {open_quotes}B{close_quotes} Mega-YAC library. This YAC includes two highly polymorphic dinucleotide repeat sequences that will facilitate genetic studies of the contribution of ADCYAP1R1 in disease states of the central nervous and neuroendocrine systems. 13 refs., 1 fig.

1994-10-01

463

Habitat segregation and genetic relationship of two heptageniid mayflies, Epeorus latifolium and Epeorus l-nigrus, in the Shinano-gawa River basin

In quantifying health risks arising from radiation exposure and synergistic effects promoted by radiation the dose-effect relationship must be used as a basis. Special problems arise in the extrapolation of experimental results or in the treatment of data in the region of low doses administered over long periods of time. For radiation protection purposes, especially manifestations of cancer and genetic effects are significant. The International Commission on Radiation Protection has published binding guiding values on the basis of which to assess the risk of cancer. The cancer risk and genetic risks are estimated for relevant dose ranges and compared with other factors of civilization. For the most important chemical pollutants emitted into the environment the possibilities of impacts arising from synergistic effects are discussed on the basis of the rules and regulations specified in German antipollution legislation. (orig.) 891 HP/orig. 892 ...

1979-10-03

464

British Library Electronic Table of Contents (United Kingdom)

The heptageniid mayflies Epeorus latifolium and Epeorus l-nigrus are often the dominant species in the upper and midstream areas of Japanese rivers; as such, they play a significant role in river ecosystems. However, although these two species have been identified using the morphological characteristics of the male in its adult stage, it is impossible to differentiate them in their nymphal stage. We conducted a study to elucidate their distribution pattern, i.e., the current distribution of these two species in the Shinano-gawa River basin, based on quantitative field sampling and genetic analysis of nymphs and also some male adults; for these, it was possible to differentiate between the two species reliably. The data collected from the 30 study sites of the 1-year-long study revealed tha...

2011-01-01

465

Gravitational Lens Modeling with Genetic Algorithms and Particle Swarm Optimizers

Genomic architecture of aggression: Rare copy number variants in intermittent explosive disorder

Strong gravitational lensing of an extended object is described by a mapping from source to image coordinates that is nonlinear and cannot generally be inverted analytically. Determining the structure of the source intensity distribution also requires a description of the blurring effect due to a point spread function. This initial study uses an iterative gravitational lens modeling scheme based on the semilinear method to determine the linear parameters (source intensity profile) of a strongly lensed system. Our 'matrix-free' approach avoids construction of the lens and blurring operators while retaining the least squares formulation of the problem. The parameters of an analytical lens model are found through nonlinear optimization by an advanced genetic algorithm (GA) and particle swarm optimizer (PSO). These global optimization routines are designed to explore the parameter space thoroughly, mapping model degeneracies in detail. We develop a novel method that ...

2011-01-01

466

British Library Electronic Table of Contents (United Kingdom)

Abstract Copy number variants (CNVs) are known to be associated with complex neuropsychiatric disorders (e.g., schizophrenia and autism) but have not been explored in the isolated features of aggressive behaviors such as intermittent explosive disorder (IED). IED is characterized by recurrent episodes of aggression in which individuals act impulsively and grossly out of proportion from the involved stressors. Previous studies have identified genetic variants in the serotonergic pathway that play a role in susceptibility to this behavior, but additional contributors have not been identified. Therefore, to further delineate possible genetic influences, we investigated CNVs in individuals diagnosed with IED and/or personality disorder (PD). We carried out array comparative genomic hybridizati...

2011-01-01

467

Genetic testing for hereditary cancer: Effects of alexithymia and coping strategies on variations in anxiety before and after result disclosure

British Library Electronic Table of Contents (United Kingdom)

This study assessed the impact of the results of genetic testing for hereditary cancer from a multifactorial health psychology perspective, considering that emotional expression plays a key role in psychological adjustment. Measures of dispositional and transactional coping strategies, anxiety and alexithymia were filled out by 77 participants in a longitudinal study design. Statistical analyses were performed using general linear models and partial least squares path modelling, low-constraint methods that are particularly useful in the behavioural sciences. While anxiety levels prior to the result announcement were predictive of the distress experienced by noncarriers, considerable variability was observed for mutation carriers. Some subjects who had lower anxiety levels before the test d...

2011-01-01

468

Fault diagnosis on bottle filling plant using genetic-based neural network

British Library Electronic Table of Contents (United Kingdom)

Timely detection of the pneumatic system problems is important in industry. Many techniques have been employed to solve this problem. In this paper, Genetic Algorithm (GA) based optimal configuration of neural networks is proposed for fault diagnostic of bottle filling systems. Back-propagation is used for neural networks algorithm. The back-propagation algorithm had six inputs and one output. A fitness function was designed to the minimize execution time of ANN model by keeping the number of hidden layer(s) and nodes as low as possible while the mean square error of estimated output error is minimized. The designed GA-ANN combination and the graphical user interface (GUI) eliminate the trial and error process for selection of the fastest and most accurate configuration. The performance of...

2011-01-01

469

Design of recurrent neural network power system stabilizer based on genetic algorithm

Continuous human cell lines and method of making same

A new recurrent neural network power system stabilizer (RNNPSS) based on genetic algorithm (GA) was presented. It shows faster convergence than the linear quadratic regulator (LQR) stabilizer in a multi-machine power system, because the proposed GA based neural network was first trained off-line to determine the optimal values of the learning rates. Otherwise, the RNNPSS consists of just two layers. As such, the time consumption of the damping oscillations is lower than with conventional methods. In addition, the operating range of the RNNPSS is greater than that of the LQR and conventional three layer neural networks, since the RNNPSS can greatly reduce system complexity and effectively damp system oscillations. 9 refs., 7 figs.

2008-07-01

470

Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats

Substantially genetically stable continuous human cell lines derived from normal human mammary epithelial cells (HMEC) and processes for making and using the same. In a preferred embodiment, the cell lines are derived by treating normal human mammary epithelial tissue with a chemical carcinogen such as benzo(a)pyrene. The novel cell lines serve as useful substrates for elucidating the potential effects of a number of toxins, carcinogens and mutagens as well as of the addition of exogenous genetic material. The autogenic parent cells from which the cell lines are derived serve as convenient control samples for testing. The cell lines are not neoplastically transformed, although they have acquired several properties which distinguish them from their normal progenitors. 2 tabs.

1985-07-01

471

British Library Electronic Table of Contents (United Kingdom)

To test the hypothesis that transduction of the channelrhodopsin-2 (ChR2) gene, a microbial-type rhodopsin gene, into retinal ganglion cells of genetically blind rats will restore functional vision, we recorded visually evoked potentials and tested the experimental rats for the presence of optomotor responses. The N-terminal fragment of the ChR2 gene was fused to the fluorescent protein Venus and inserted into an adeno-associated virus to make AAV2-ChR2V. AAV2-ChR2V was injected intravitreally into the eyes of 6-month-old dystrophic RCS (rdy/rdy) rats. Visual function was evaluated six weeks after the injection by recording visually evoked potentials (VEPs) and testing optomotor responses. The expression of ChR2V in the retina was investigated histologically. We found that VEPs could not b...

2010-01-01

472

Australian experience with herbicide tolerant (HT) and Bacillus thuringiensis (Bt) cotton

British Library Electronic Table of Contents (United Kingdom)

Australia?s nationally consistent framework for gene technology regulation is underpinned by the Gene Technology Act 2000, administered by an independent decision-maker, the Gene Technology Regulator. The object of the Act is ?to protect the health and safety of people, and to protect the environment, by identifying risks posed by or as a result of gene technology, and by managing those risks through regulating certain dealings with genetically modified organisms?. Marketing and trade impacts are outside the scope of assessments required by the Act. Since 2001, seven licences have been issued for the commercial cultivation of genetically modified (GM) cotton with insect resistance and/or herbicide tolerance. Licences have also been issued for 32 GM cotton field trials with a broader range ...

2011-01-01

473

Vectorization and Parallelization of the Adaptive Mesh Refinement N-body Code

Valuing climate protection through willingness to pay for biomass ethanol

In this paper, we describe our vectorized and parallelized adaptive mesh refinement (AMR) N-body code with shared time steps, and report its performance on a Fujitsu VPP5000 vector-parallel supercomputer. Our AMR N-body code puts hierarchical meshes recursively where higher resolution is required and the time step of all particles are the same. The parts which are the most difficult to vectorize are loops that access the mesh data and particle data. We vectorized such parts by changing the loop structure, so that the innermost loop steps through the cells instead of the particles in each cell, in other words, by changing the loop order from the depth-first order to the breadth-first order. Mass assignment is also vectorizable using this loop order exchange and splitting the loop into $2^{N_{dim}}$ loops, if the cloud-in-cell scheme is adopted. Here, $N_{dim}$ is the number of dimension. These vectorization schemes which eliminate the unvectorized loops are ...

2005-01-01

474

Uplink Capacity and Interference Avoidance for Two-Tier Cellular Networks

This study uses a multi-part, split-sample contingent valuation method (CVM) and fair share (FS) survey to better understand the public's valuation of mitigating global climate change through its willingness to pay for biomass or 'cellulosic' ethanol. In addition to a basic CVM question, a related scenario was developed that asked half of the survey respondents to state their fair share cost to lessen a potential food shortage in the next decade, also through the expanded use of cellulosic ethanol. Three alternative biomass feedstocks were assessed: farming residues, forestry residues and paper mill wastes, and municipal solid wastes. Overall a slightly larger proportion of respondents were WTP extra for cellulosic ethanol in the basic CVM scenario than in the FS scenario, though no significant differences were found in the WTP for the different feedstocks. Bid curve lognormal regression results for the two models ...

2009-05-15

475

Some observations on the flow of financial resources to developing countries

This paper presents an uplink capacity analysis and interference avoidance technique for a femtocell based two-tier DS-CDMA network using shared spectrum. Assuming randomly distributed macrocell users and femtocell base stations (BS), we evaluate a network-wide area spectral efficiency metric called the operating contour (OC) defined as the feasible combinations of the average macrocell users and femtocell BS per cell-site that meet a target outage constraint $\\epsilon$. A contribution of this work is an accurate characterization of the uplink outage probability taking cross-tier power control, path-loss and shadowing effects into account. We show that a time-hopped CDMA physical layer coupled with sectorized receive antennas shows dramatic performance improvements in both light and heavily loaded two-tier networks, relative to a split spectrum two-tier network with omnidirectional femtocell antennas. These results provide insights into design of robust ...

2007-01-01

476

Resolving conflicting safety cultures

This paper highlights some of the conceptual and methodological problems involved in the compilation of statistics on economic aid to developing countries. Figures from the OECD Development Assistance Committee (DAC) and the Organization of Petroleum Exporting Countries (OPEC) member states are compared to point up problems in the interpretation of the statistics. One area of concern is the listing of funds provided by financial institutions located in the DAC countries. OPEC capital often forms a majority of such institutions; yet the figures do not measure the OPEC share of the capital nor its share of the risk borne in its provision of the loans. Another area of concern is bond purchases and subscriptions to syndicated loans by OPEC financial institutions in the financial markets of DAC countries. The flows in these instances, originating from OPEC sources, are merely channeled through the DAC financial markets. Based on origin and risk ...

1980-03-01

477

Internalizing externalities of electricity generation: An analysis with MESSAGE-MACRO

Several nuclear power plant sites have been wounded in the crossfire between two distinct corporate cultures. The traditional utility culture lies on one side and that of the nuclear navy on the other. The two corporate cultures lead to different perceptions of open-quotes safety culture.close quotes This clash of safety cultures obscures a very important point about nuclear plant operations: Safety depends on organizational learning. Organizational learning provides the foundation for a perception of safety culture that transcends the conflict between utility and nuclear navy cultures. Corporate culture may be defined as the knowledge, attitudes, and beliefs shared by employees of a given company. Safety culture is the part of corporate culture concerning shared attitudes and beliefs affecting individual or public safety. If the safety culture promotes behaviors that lead to greater safety, employees will tend to open-quotes do the right ...

1993-06-20

478

Internalizing externalities of electricity generation: An analysis with MESSAGE-MACRO

This paper examines the global impacts of a policy that internalizes the external costs (related to air pollution damage, excluding climate costs) of electricity generation using a combined energy systems and macroeconomic model. Starting point are estimates of the monetary damage costs for SO{sub 2}, NO {sub X} , and PM per kWh electricity generated, taking into account the fuel type, sulfur content, removal technology, generation efficiency, and population density. Internalizing these externalities implies that clean and advanced technologies increase their share in global electricity production. Particularly, advanced coal power plants, natural gas combined cycles, natural gas fuel cells, wind and biomass technologies gain significant market shares at the expense of traditional coal- and gas-fired plants. Global carbon dioxide emissions are lowered by 3% to 5%. Sulfur dioxide emissions drop significantly below the already low level. The ...

2007-02-15

479

Interactions among transportation fuel substitution, vehicle quality growth, and national economic growth

This paper examines the global impacts of a policy that internalizes the external costs (related to air pollution damage, excluding climate costs) of electricity generation using a combined energy systems and macroeconomic model. Starting point are estimates of the monetary damage costs for SO{sub 2}, NOX, and PM per kWh electricity generated, taking into account the fuel type, sulfur content, removal technology, generation efficiency, and population density. Internalizing these externalities implies that clean and advanced technologies increase their share in global electricity production. Particularly, advanced coal power plants, natural gas combined cycles, natural gas fuel cells, wind and biomass technologies gain significant market shares at the expense of traditional coal- and gas-fired plants. Global carbon dioxide emissions are lowered by 3% to 5%. Sulfur dioxide emissions drop significantly below the already low level. The policy ...

2007-02-15

480

Fundamentals of Inter-cell Overhead Signaling in Heterogeneous Cellular Networks

Estimates of annual rates of change of fuel switching are constructed using logistic curve models fitted to often sparse historical data on fuel use in the USA. The estimated annual rate of loss of market share of an old fuel is then shown to be correlated with five-year averages of declines in the rate of growth of affected vehicle numbers. Other statistical tests show a positive correlation between five-year average changes in the rate of growth of the vehicle numbers and of macroeconomic activity when the affected vehicles are directly responsible for a large share of that activity. The vehicle types shown to have this effect are locomotives from 1885-1915 and automobiles thereafter. The third set of tests supports an interpretation that the indirect effects of fuel switches are significant and consistent with GNP throughout the 1880-1980 period. It is shown that a pronounced drop in GNP growth occurs at the time when the important fuel ...

1989-05-01

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481

Financing Projects That Use Clean Energy Technologies: An Overview of Barriers and Opportunities

Heterogeneous base stations (e.g. picocells, microcells, femtocells and distributed antennas) will become increasingly essential for cellular network capacity and coverage. Up until now, little basic research has been done on the fundamentals of managing so much infrastructure -- much of it unplanned -- together with the carefully planned macro-cellular network. Inter-cell coordination is in principle an effective way of ensuring different infrastructure components behave in a way that increases, rather than decreases, the key quality of service (QoS) metrics. The success of such coordination depends heavily on how the overhead is shared, and the rate and delay of the overhead sharing. We develop a novel framework to quantify overhead signaling for inter-cell coordination, which is usually ignored in traditional 1-tier networks, and assumes even more importance in multi-tier heterogeneous cellular networks (HCNs). We derive the overhead quality ...

2011-01-01

482

Federated sigma point filter for multi-sensor attitude and rate estimation of spacecraft

Project finance is asset-based financing, meaning that the project lenders have recourse only to the underlying assets of a project. It involves both debt and equity, where the debt-to-equity ratio is typically large (e.g., 70% debt to 30% equity). Debt is used when available and when it is the least expensive form of financing, with equity still needed for credit worthiness. Most important, revenue from the project must be able to generate a return to the equity investors, and pay for interest and principal on the debt, transaction costs associated with developing and structuring the project, and operations and maintenance costs. Successful project financing must provide a structure to manage and share risks in an optimal way that benefits all participants, allocating risks to those entities that are able to mitigate each specific risk, and to share information about putting risk management in the proper hands at the proper stage of project ...

2005-10-01

483

FastFlow: Efficient Parallel Streaming Applications on Multi-core

High precision, fast computation speed, as well as a good capability of fault tolerant and reconstruction are required more and more for spacecraft attitude determination system. To realize the above requirement, an approach was presented to the synthesis of federated filters using sigma point technique. In this algorithm, the sigma point technique brought the algorithm a high precision, while the federated structure significantly enhanced the filters' capability of multi-rate information fusion, fault tolerance, and system modularity. Within consideration of computation consumption, a simple information-sharing formulation was derived to adapt to the special property of sigma point distribution, and a dynamical information sharing strategy for multi-rate fusion was developed. A numerical simulation example was employed to give the algorithm a test, where the simulated system contained a suit of gyroscopes; a three-axis magnetometer and a sun ...

2008-11-01

484

Development of the high-tension distribution line design support system; Koatsu gaisen sekkei shien system no kaihatsu

Shared memory multiprocessors come back to popularity thanks to rapid spreading of commodity multi-core architectures. As ever, shared memory programs are fairly easy to write and quite hard to optimise; providing multi-core programmers with optimising tools and programming frameworks is a nowadays challenge. Few efforts have been done to support effective streaming applications on these architectures. In this paper we introduce FastFlow, a low-level programming framework based on lock-free queues explicitly designed to support high-level languages for streaming applications. We compare FastFlow with state-of-the-art programming frameworks such as Cilk, OpenMP, and Intel TBB. We experimentally demonstrate that FastFlow is always more efficient than all of them in a set of micro-benchmarks and on a real world application; the speedup edge of FastFlow over other solutions might be bold for fine grain tasks, as an example +35% on OpenMP, +226% on ...

2009-01-01

485

Deterministic secure direct communication using GHZ states and swapping quantum entanglement

The 'high-tension distribution line design support system' was developed for the 'work design support system'. This support system is composed of the work outline editor for preparing work details and facility data and the inference engine for preparing practical design plans, and can check system conditions such as voltage drop and deviation from technical standards automatically. The work outline editor takes charge of selection of work items, selective input of system information, and setting of some conditions such as pole position and reserved load onto a system diagram. The inference engine provides the design plan automatically based on the information inputted by the editor. For the design of high-tension distribution line, such various factors as local condition and load sharing of distribution systems should be considered. This design support system attains efficient processing by not total automation of design works ...

2000-02-10

486

Controlling federal costs for coal liquefaction program hinges on management and contracting improvements

We present a deterministic secure direct communication scheme via entanglement swapping, where a set of ordered maximally entangled three-particle states (GHZ states), initially shared by three spatially separated parties, Alice, Bob and Charlie, functions as a quantum information channel. After ensuring the safety of the quantum channel, Alice and Bob apply a series of local operations on their respective particles according to the tripartite stipulation and the secret message they both want to send to Charlie. By three of Alice, Bob and Charlie's Bell measurement results, Charlie is able to infer the secret messages directly. The secret messages are faithfully transmitted from Alice and Bob to Charlie via initially shared pairs of GHZ states without revealing any information to a potential eavesdropper. Since there is no transmission of the qubits carrying the secret message between any two of them in the public channel, it is completely ...

2005-06-24

487

A tool for the LHCb MWPC production monitoring the LNF on-line database

GAO's review of the H-Coal and Exxon projects showed inadequacies in DOE's contracting practices and a failure by DOE to properly plan, manage, and monitor, especially the H-Coal project. The initial Government-industry H-Coal agreements regarding the level of investment by private sponsors and the ceilings imposed on sharing in cost growth were imbalanced. Larger investments by private sponsors and sharing of cost growth provides an incentive to private sponsors to control costs and helps to assure that each party is fully committed to the success of the project. DOE started the H-Coal project prematurely before sufficiently detailed designs were available and without adequate project planning for functions such as construction scheduling, materials handling, inventory systems, and quality control. DOE staffing was inadequate at both projects to effectively monitor progress and contribute to timely decisions. Its contracts ...

1981-02-04

488

Wind-To-Hydrogen Project: Operational Experience, Performance Testing, and Systems Integration

The LHCb Muon detector system is made of several (1368) Multi Wire Proportional Chambers (MWPCs). Those chambers differ in size, readout and constructing materials and are built in various countries: their assembly takes place in different sites and foresee many steps. To ensure the production quality and keep track of panels/chambers production an on-line database has been set up. This web based tool allows an easy sharing of the information: the database update is made possible trough a web interface. The update is easy and reliable. The interface helps the information sharing in different sites and helps optimizing the production rate by allowing feedback on production needs and quality between sites contributing to the production chain. The planning is made using the information on the material availability. Quality tests and crosschecks are made easier, as well as the overall production monitoring. The tool has been developed using mySQL, ...

2006-01-01

489

Ventilation on demand: The efficient way to ensure clean air; Bedarfsgeregelte Lueftung: Dicke Luft wirtschaftlich verhindern

The Wind2H2 system is fully functional and continues to gather performance data. In this report, specifications of the Wind2H2 equipment (electrolyzers, compressor, hydrogen storage tanks, and the hydrogen fueled generator) are summarized. System operational experience and lessons learned are discussed. Valuable operational experience is shared through running, testing, daily operations, and troubleshooting the Wind2H2 system and equipment errors are being logged to help evaluate the reliability of the system.

2009-03-01

490

Two Avowable Quantum Communication Schemes

Ventilation systems must ensure high room air quality with minimum energy consumption in all states of operation. Systems for ventilation on demand are increasing their market share. (orig./MSK) [Deutsch] Oberste Aufgabe von Raumlufttechnischen Anlagen ist die Sicherstellung guter Raumluftqualitaet bei minimalem Energieverbrauch unter allen Betriebsbedingungen. Um dieses Ziel zu erreichen, setzt sich am Markt zunehmend die bedarfsgeregelte Lueftung durch. (orig./MSK)

1997-11-01

491

Two Avowable Quantum Communication Schemes

Two avowable quantum communication schemes are proposed. One is an avowable teleportation protocol based on the quantum cryptography. In this protocol one teleports a set of one-particle states based on the availability of an honest arbitrator, the keys and the Einstein-Podolsky-Rosen pairs shared by the communication parties and the arbitrator. The key point is that the fact of the teleportation can neither be disavowed by the sender nor be denied by the receiver. Another is an avowable quantum secure direct communication scheme. A one-way Hash function chosen by the communication parties helps the receiver to validate the truth of the information and to avoid disavowing for the sender.

2008-11-15

492

The law of one price: an examination of price integration between Europe and regional markets in Africa

Two avowable quantum communication schemes are proposed. One is an avowable teleportation protocol based on the quantum cryptography. In this protocol one teleports a set of one-particle states based on the availability of an honest arbitrator, the keys and the Einstein Podolsky Rosen pairs shared by the communication parties and the arbitrator. The key point is that the fact of the teleportation can neither be disavowed by the sender nor be denied by the receiver. Another is an avowable quantum secure direct communication scheme. A one-way Hash function chosen by the communication parties helps the receiver to validate the truth of the information and to avoid disavowing for the sender.

2008-11-01

493

British Library Electronic Table of Contents (United Kingdom)

This study examines the degree of price-integration of equity indices between the major markets of Africa, namely Morocco, Tunisia, Egypt, Kenya, Nigeria, Namibia and South Africa with the European markets of London and Paris. Vector Autoregressive and Autoregressive Distributed Lag methods reveal that African markets are largely price-segmented. The only markets that are price-integrated have shared economic and financial institutions, such as Namibia and South Africa, and Egypt, Tunisia and France. The evidence suggests that development policy should be focussed on enhancing existing institutions rather than embarking prematurely on regional integration.

2012-01-01

494

Quantum Secure Direct Communication with Four-Particle Genuine Entangled State and Dense Coding

Efficient quantum secure communication scheme with one-time pad

A quantum secure direct communication scheme using dense coding is proposed. At first, the sender (Alice) prepares four-particle genuine entangled states and shares them with the receiver (Bob) by sending two particles in each entangled state to him. Secondly, Alice encodes secret information by performing the unitary transformations on her particles and transmits them to Bob. Finally, Bob performs the joint measurements on his particles to decode the secret information. The two-step security test guarantees the security of communication.

2009-07-01

495

Does energy substitution affect carbon dioxide emissions - Income relationship?

In this paper, we proposed a novel quantum secure direct communication scheme with one-time pad in stabilizer formalism. Based on the reuse of qubit sequence, an efficient secure communication of secret messages without first producing a shared secret key can be achieved. One hence may find that the amount of private key needed for quantum communication is smaller than that in the general case. Therefore, the present protocol which is feasible with the present-day techniques may be applied to quantum communication with short-length encoding.

2009-05-01

496

British Library Electronic Table of Contents (United Kingdom)

Considerable discussion has taken place during the last decade regarding the role of economic growth in determining environmental quality. Using data from 30 OECD countries for the period 1960-2003 and the nonparametric method of generalized additive models, which enables us to use flexible functional forms, this paper examines the environmental Kuznets curve hypothesis for carbon dioxide (CO2). We find that the reduction of coal share in energy use has a significant effect on CO2. Our results imply that economic growth is not sufficient to decrease CO2 emissions.

2010-01-01

497

Depression and chronic fatigue in the patient with chronic pain.

Database management system for instrument data management

Chronic benign pain is commonly associated with chronic fatigue and depression. Depression and chronic fatigue syndrome are also associated with each other and often include pain. Psychologic factors are prominent in these conditions, and they may share neurobiologic factors as well. Management requires separately addressing each component of patients' distress and usually includes physical rehabilitation, education, administration of nonhabituating medications and often counseling. Depression may be a favorable prognostic sign, as it suggests a treatable condition and provides incentive for recovery. PMID:1876618

1991-06-01

498

Alberta oil sands royalty regime

Data from many measuring devices throughout the Savannah River Site (SRS) is transmitted to a central location for processing as a vital component in the SRS emergency preparedness and response program. The data processing is currently accomplished using VAX-based FORTRAN programs with the data stored in Digital's Record Management System (RMS) files which is shared using global COMMON. A program is underway to store and process this data using a Structured Query Language (SQL)-based Database Management System (DBMS). The advantages of replacing the current system with one using an SQL-based DBMS are discussed.

1990-01-01

499

Advanced Power Electronics Interfaces for Distributed Energy Workshop Summary: August 24, 2006, Sacramento, California

The long term objective of the Oil Sands Business Unit of Alberta Energy is to pave the way for Alberta's bitumen production to reach 3 million barrels per day by 2020. This presentation described the national government's role in resource development. It was emphasized that since the Crown is the owner of the oil sands resource, it would benefit by providing strategic leadership and by generating a larger royalty base. The oil sands fiscal regime was described with reference to generic royalty, risk sharing, investment, and project economics. Business rule principles were also outlined along with criteria for project expansions. Both upstream and downstream challenges and opportunities were listed. 4 figs.

2004-01-29

500