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1

Caenorhabditis elegans Pheromones Regulate Multiple Complex Behaviors  

UK PubMed Central (United Kingdom)

Summary of recent advancesA family of small molecules called ascarosides act as pheromones to control multiple behaviors in the nematode Caenorhabditis elegans....Full Text Available

2009-08-01

2

A Genomewide RNAi Screen for Genes That Affect the Stability, Distribution and Function of P Granules in Caenorhabditis elegans  

UK PubMed Central (United Kingdom)

P granules are non-membrane-bound organelles found in the germ-line cytoplasm throughout Caenorhabditis elegans development. Like their “germ granule” counterparts in...Full Text Available

2009-12-01

3

Global 'worming'  

UK PubMed Central (United Kingdom)

A report on the 16th International Caenorhabditis elegans Meeting, Los Angeles, USA, 27 June-1 July 2007.

2007-01-01

4

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB  

UK PubMed Central (United Kingdom)

Activating AMPK or inactivating calcineurin slows ageing in Caenorhabditis elegans1,2...Full Text Available

2011-02-17

5

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans  

UK PubMed Central (United Kingdom)

The nuo-6 and isp-1 genes of C. elegans encode, respectively, subunits of complex I and III of the mitochondrial respiratory chain. Partial loss-of-function...Full Text Available

2010-12-01

6

Zebrafish TRPA1 Channels are Required for Chemosensation but not for Thermosensation or Mechanosensory Hair Cell Function  

UK PubMed Central (United Kingdom)

Transient receptor potential (TRP) ion channels have been implicated in detecting chemical, thermal and mechanical stimuli in organisms ranging from mammals to Caenorhabditis elegans....Full Text Available

2008-10-01

7

Variable Pathogenicity Determines Individual Lifespan in Caenorhabditis elegans  

UK PubMed Central (United Kingdom)

A common property of aging in all animals is that chronologically and genetically identical individuals age at different rates. To unveil mechanisms that influence aging variability, we identified markers...Full Text Available

2011-04-01

8

The Dystrophin Complex Controls BK Channel Localization and Muscle Activity in Caenorhabditis elegans  

UK PubMed Central (United Kingdom)

Genetic defects in the dystrophin-associated protein complex (DAPC) are responsible for a variety of pathological conditions including muscular dystrophy, cardiomyopathy, and vasospasm. Conserved DAPC...Full Text Available

2009-12-01

9

The Caenorhabditis elegans Elongator Complex Regulates Neuronal ?-tubulin Acetylation  

UK PubMed Central (United Kingdom)

Although acetylated α-tubulin is known to be a marker of stable microtubules in neurons, precise factors that regulate α-tubulin acetylation are, to date, largely unknown. Therefore,...Full Text Available

2010-01-01

10

Stressed-Induced TMEM135 Protein Is Part of a Conserved Genetic Network Involved in Fat Storage and Longevity Regulation in Caenorhabditis elegans  

UK PubMed Central (United Kingdom)

Disorders of mitochondrial fat metabolism lead to sudden death in infants and children. Although survival is possible, the underlying molecular mechanisms which enable this outcome have not yet been...Full Text Available

11

Regulation of DAF-16-mediated Innate Immunity in Caenorhabditis elegans*  

UK PubMed Central (United Kingdom)

Activation of the innate immune system results in a rapid microbicidal response against microorganisms, which needs to be fine-tuned because uncontrolled immune responses can lead to infection and cancer,...Full Text Available

2009-12-18

12

Purpose and regulation of stem cells: a systems-biology view from the Caenorhabditis elegans germ line  

UK PubMed Central (United Kingdom)

Stem cells are expected to play a key role in the development and maintenance of organisms, and hold great therapeutic promises. However, a number of questions must be answered to achieve an...Full Text Available

2009-01-01

13

PDP-1 Links the TGF-? and IIS Pathways to Regulate Longevity, Development, and Metabolism  

UK PubMed Central (United Kingdom)

The insulin/IGF-1 signaling (IIS) pathway is a conserved regulator of longevity, development, and metabolism. In Caenorhabditis elegans IIS involves activation of DAF-2 (insulin/IGF-1...Full Text Available

2011-04-01

14

Membrane Efflux and Influx Modulate both Multidrug Resistance and Virulence of Klebsiella pneumoniae in a Caenorhabditis elegans Model?  

UK PubMed Central (United Kingdom)

Cross-resistance to cefoxitin (FOX), chloramphenicol (CMP), and quinolones (nalidixic acid [NAL]) related to a putative efflux system overexpression has recently been reported for Klebsiella...Full Text Available

2010-10-01

15

A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans  

UK PubMed Central (United Kingdom)

The decline in immune function with aging, known as immunosenescence, has been implicated in evolutionarily diverse species, but the underlying molecular mechanisms are not understood. During aging...Full Text Available

2011-05-01

16

Disruption of the ATP-binding Cassette B7 (ABTM-1/ABCB7) Induces Oxidative Stress and Premature Cell Death in Caenorhabditis elegans*  

UK PubMed Central (United Kingdom)

X-linked sideroblastic anemia with ataxia (XLSA/A) is a rare inherited disorder characterized by mild anemia and ataxia. XLSA/A is caused by mutations in the ABCB7 gene, which encodes...Full Text Available

2011-06-17

17

A Role for Set1/MLL-Related Components in Epigenetic Regulation of the Caenorhabditis elegans Germ Line  

UK PubMed Central (United Kingdom)

The methylation of lysine 4 of Histone H3 (H3K4me) is an important component of epigenetic regulation. H3K4 methylation is a consequence of transcriptional activity, but also has been shown to contribute...Full Text Available

2011-03-01

18

Steinernema diaprepesi (Nematoda: Steinernematidae): Its Occurrence in Western Mexico and Susceptibility of Engorded ...  

Science.gov (United States)

... 663. 2009 doi: 10.1653/024.092.0423 Steinernema diaprepesi (Nematoda: Steinernematidae): Its Occurrence in...

19

Molecular determinants archetypical to the phylum Nematoda  

UK PubMed Central (United Kingdom)

BackgroundNematoda diverged from other animals between 600–1,200 million years ago and has become one of the most diverse animal phyla on earth. Most nematodes are free-living...Full Text Available

20

C. elegans as a model for stem cell biology  

UK PubMed Central (United Kingdom)

We review the application of C. elegans as a model system to understand key aspects of stem cell biology. The only bona fide stem cells in C. elegans...Full Text Available

2010-05-01

 
 
 
 
21

Calcineurin may regulate multiple endocytic processes in C. elegans  

KoreaScience (Korea)

Full Text Available

2011-02-01

22

Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells  

UK PubMed Central (United Kingdom)

Germline-specific granules of unknown function are found in a wide variety of organisms, including C. elegans, where they are called P granules. P granules are cytoplasmic bodies...Full Text Available

2010-04-15

23

Simultaneous recognition and segmentation of cells: application in C.elegans  

UK PubMed Central (United Kingdom)

Motivation: Automatic recognition of cell identities is critical for quantitative measurement, targeting and manipulation of cells of model animals at single-cell resolution. It has been...Full Text Available

2011-10-15

24

Subulura lacertilia sp.n. (Nematoda, Subuluridae) parasitizing the Brazilian lizard Tropidurus nanuzae Rodrigues (Lacertilia, Tropiduridae)  

Scientific Electronic Library Online (English)

Abstract in english This report deals with the identification of samples of nematodes recovered from Tropidurus nanuzae Rodrigues, 1981, with the description of a new species, and is a part of a major study on helminth parasites of reptiles in Brazil, taking into account previous data on this subject. The main approach is that referring to the first occurrence of subulurid nematodes in a reptilian host, since they have been assigned previously to birds and mammals.

2000-12-01

25

Natural variation in life history and aging phenotypes is associated with mitochondrial DNA deletion frequency in Caenorhabditis briggsae  

UK PubMed Central (United Kingdom)

BackgroundMutations that impair mitochondrial functioning are associated with a variety of metabolic and age-related disorders. A barrier to rigorous tests of the role of mitochondrial...Full Text Available

26

The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity  

UK PubMed Central (United Kingdom)

SummaryThe life span of C. elegans can be increased via reduced function of the mitochondria; however, the extent to which mitochondrial alteration in a single,...Full Text Available

2011-01-07

27

Regulation of life span by mitochondrial respiration: the HIF-1 and ROS connection  

UK PubMed Central (United Kingdom)

A mild reduction in mitochondrial respiration extends the life span of many species, including C. elegans. We recently showed that hypoxia-inducible factor 1 (HIF-1) is required for...Full Text Available

28

Modulation of lipid biosynthesis contributes to stress resistance and longevity of C. elegans mutants  

UK PubMed Central (United Kingdom)

Many lifespan-modulating genes are involved in either generation of oxidative substrates and end-products, or their detoxification and removal. Among such metabolites, only lipoperoxides have the ability...Full Text Available

29

Gene expression profiling of oxidative stress response of C. elegans aging defective AMPK mutants using massively parallel transcriptome sequencing  

UK PubMed Central (United Kingdom)

BackgroundA strong association between stress resistance and longevity in multicellular organisms has been established as many mutations that extend lifespan also show increased...Full Text Available

30

Biochemical analysis of PIFTC3, the Trypanosoma brucei ortholog of nematode DYF-13, reveals interactions with established and putative intraflagellar transport components  

UK PubMed Central (United Kingdom)

DYF-13, originally identified in C. elegans within a collection of dye-filling chemosensory mutants, is one of several proteins that have been classified as putatively involved...Full Text Available

2010-10-01

31

Absence of Ataxin-3 Leads to Enhanced Stress Response in C. elegans  

UK PubMed Central (United Kingdom)

Ataxin-3, the protein involved in Machado-Joseph disease, is able to bind ubiquitylated substrates and act as a deubiquitylating enzyme in vitro, and it has been involved in the modulation of protein...Full Text Available

32

A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding  

UK PubMed Central (United Kingdom)

BackgroundProteins may evolve through the recruitment and modification of discrete domains, and in many cases, protein action can be dissected at the domain level. PDZ domains are...Full Text Available

33

Marine Flatworms, Leslie Newman and Lester Cannon, 9780643101197  

Wastenet

...Marine Flatworms provides a fascinating introduction to the intriguing world of polyclad flatworms, a group of large, free-living marine Platyhelminthes, which are found throughout the world but are most colourful in tropical waters. Although not related to molluscs, they are often mistaken for sea slugs ...com Marine Flatworms provides a fascinating introduction to the intriguing world of polyclad flatworms, a group of large, free-living marine Platyhelminthes, which are found throughout the world but are most colourful in tropical waters. Although not related to molluscs, they are often mistaken for sea ...the world Over 300 stunning full colour photographs Brings together polyclads worldwide Newly developed key to polyclad families Introduction The world of worms Flatworms (Phylum:Platyhelminthes) Segmented Worms (Phylum: Annelida) Round worms (Nematoda) Other worms The polyclad body Habitat and lifestyle Colours and ...

34

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in a-synuclein transgenic C. elegans  

British Library Electronic Table of Contents (United Kingdom)

Mutations or multiplications in a-synuclein gene cause familial forms of Parkinson disease or dementia with Lewy bodies (LB), and the deposition of wild-type a-synuclein as LB occurs as a hallmark lesion of these disorders, collectively referred to as synucleinopathies, implicating a-synuclein in the pathogenesis of synucleinopathy. To identify modifier genes of a-synuclein-induced neurotoxicity, we conducted an RNAi screen in transgenic C. elegans (Tg worms) that overexpress human a-synuclein in a pan-neuronal manner. To enhance the RNAi effect in neurons, we crossed a-synuclein Tg worms with an RNAi-enhanced mutant eri-1 strain. We tested RNAi of 1673 genes related to nervous system or synaptic functions, and identified 10 genes that, upon knockdown, caused severe growth/motor abnormalit...

2008-01-01

35

Effect of temperature on the development of Steinernema carpocapsae and Steinernema feltiae (Nematoda: Rhabditida) in liquid culture.  

Science.gov (United States)

For commercial use of the entomopathogenic nematodes Steinernema carpocapsae and Steinernema feltiae in biological control of insect pests, they are produced in liquid culture on artificial media pre-incubated with their symbiotic bacteria Xenorhabdus nematophila and Xenorhabdus bovienii, respectively. After 1 day of the bacterial culture, nematode dauer juveniles (DJs) are inoculated, which recover development. The adult nematodes produce DJ offspring, which are harvested and can be sprayed. This study determined optimal temperatures to obtain high DJ progeny within a short process time. Temperatures assessed were 23 degrees C, 25 degrees C, 27 degrees C, and 29 degrees C for S. carpocapsae and 20 degrees C, 23 degrees C, 25 degrees C, and 27 degrees C for S. feltiae. The recovery of inoculated DJs was hardly affected and was reduced only in S. carpocapsae at 29 degrees C. The fecundity (eggs in uterus) in S. carpocapsae reached a maximum at 27 degrees C; whereas, maximum yields were ...

2009-05-20

36

Proving Stabilization of Biological Systems  

Science.gov (United States)

We describe an efficient procedure for proving stabilization of biological systems modeled as qualitative networks or genetic regulatory networks. For scalability, our procedure uses modular proof techniques, where state-space exploration is applied only locally to small pieces of the system rather than the entire system as a whole. Our procedure exploits the observation that, in practice, the form of modular proofs can be restricted to a very limited set. For completeness, our technique falls back on a non-compositional counterexample search. Using our new procedure, we have solved a number of challenging published examples, including: a 3-D model of the mammalian epidermis; a model of metabolic networks operating in type-2 diabetes; a model of fate determination of vulval precursor cells in the C. elegans worm; and a model of pair-rule regulation during segmentation in the Drosophila embryo. Our results show many orders of magnitude speedup in cases where ...

2011-01-01