Cao, Tong; Zhang, Yuanming; Yu, Jin
According to our collections of literature, about 400 scientific papers dealing with Chinese bryophytes have been published in China and abroad during 1990’s. Among these, more than 50 % were published in different scientific journals in China and often written in Chinese with English abstract, which are not well known and assessable for foreign bryologists. Therefore, in addition to previous Chinese literature I-III (Cao et al. 1990, Li et Zhang 1993, 1994), we present the fourth part of Chi...
Efraín J. MORENO
This is an overview of the bryological studies for Venezuela comprising the period from the early XIX century to date. The main contributors to this field have been foreign bryologists whose work, unfortunately, has not been of interest to the Venezuelan botanists.
A taxonomic study of two species of Mniaceae family (Mosses) was made based upon the microscopic features of specimens from extensive collection in Northern and Eastern Poland. The examined species of the genus Plagiomnium are treated in accordance with the new bryological classification.
Full Text Available A taxonomic study of two species of Mniaceae family (Mosses was made based upon the microscopic features of specimens from extensive collection in Northern and Eastern Poland. The examined species of the genus Plagiomnium are treated in accordance with the new bryological classification.
Australasian Bryological Newsletter — Although there have been already 26 issues, this journal has only now come to our attention. It appears bi-annually, in June and December, and is circulated without charge to all those interested within Australasia and overseas. Write to Mr. P.J. DALTON, Plant S
Cárdenas S., Angeles
The teaching of bryology in Mexico confronts various difficulties that prevent students from having at least a broad overview of what bryophytes are. There are three main problems: lack of institutional facilities, lack of specialized literature and ignorance of the structure, biology and significance of these plants on the part of teachers. To resolve these difficulties, schools must obtain the minimum necessary facilities (Microscopes, laboratory materials ans specialized literature) and re...
Staveness, Daryl; Abdelnabi, Rana; Schrier, Adam J; Loy, Brian A; Verma, Vishal A; DeChristopher, Brian A; Near, Katherine E; Neyts, Johan; Delang, Leen; Leyssen, Pieter; Wender, Paul A
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus showing a recent resurgence and rapid spread worldwide. While vaccines are under development, there are currently no therapies to treat this disease, except for over-the-counter (OTC) analgesics, which alleviate the devastating arthritic and arthralgic symptoms. To identify novel inhibitors of the virus, analogues of the natural product bryostatin 1, a clinical lead for the treatment of cancer, Alzheimer's disease, and HIV eradication, were investigated for in vitro antiviral activity and were found to be among the most potent inhibitors of CHIKV replication reported to date. Bryostatin-based therapeutic efforts and even recent anti-CHIKV strategies have centered on modulation of protein kinase C (PKC). Intriguingly, while the C ring of bryostatin primarily drives interactions with PKC, A- and B-ring functionality in these analogues has a significant effect on the observed cell-protective activity. Significantly, bryostatin 1 itself, a potent pan-PKC modulator, is inactive in these assays. These new findings indicate that the observed anti-CHIKV activity is not solely mediated by PKC modulation, suggesting possible as yet unidentified targets for CHIKV therapeutic intervention. The high potency and low toxicity of these bryologs make them promising new leads for the development of a CHIKV treatment. PMID:26900625
Wender, Paul A; Quiroz, Ryan V; Stevens, Matthew C
, thereby harnessing the power of chemists and computers to create new structures with desired functions that could be prepared in a simple, safe, economical, and green, if not ideal, fashion. Reported herein are examples of FOS associated with (a) molecular recognition, leading to the first designed phorbol-inspired protein kinase C regulatory ligands, the first designed bryostatin analogs, the newest bryologs, and a new family of designed kinase inhibitors, (b) target modification, leading to highly simplified but functionally competent photonucleases-molecules that cleave DNA upon photoactivation, (c) drug delivery, leading to cell penetrating molecular transporters, molecules that ferry other attached or complexed molecules across biological barriers, and (d) new reactivity-regenerating reagents in the form of functional equivalents of butatrienes, reagents that allow for back-to-back three-component cycloaddition reactions, thus achieving structural complexity and value with step-economy. While retrosynthetic analysis seeks to identify the best way to make a target, retrofunction analysis seeks to identify the best targets to make. In essence, form (structure) follows function. PMID:25742599