Hrbáček, J.; Urban, M.; Eis, V.; Hamšíková, E.; Tachezy, R.; Brabec, Marek; Heráček, J.
Roč. 15, č. 3 (2011), s. 172-180. ISSN 1211-8729 Institutional research plan: CEZ:AV0Z10300504 Keywords : infekce * karcinom prostaty * pohlavně přenosné nemoci * staging nádoru Subject RIV: FD - Oncology ; Hematology
Staršíchová, Andrea; Lincová, Eva; Pernicová, Zuzana; Kozubík, Alois; Souček, Karel
Brno, 2009. s. 38. ISBN 978-80-86793-12-2. [Brněnské onkologické dny /33./ a Konference pro nelékařské zdravotnické pracovníky /23./. 16.04.2009-18.04.2009, Brno] R&D Projects: GA ČR(CZ) GA204/07/0834; GA ČR(CZ) GA310/07/0961 Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702 Keywords : interleukin-6 * transforming growth factor-beta1 * prostate Subject RIV: BO - Biophysics
Souček, Karel; Phung, A.D.; Bulinski, J.C.; Harper, R.W.; McManus, M.T.; Eserich, J.P.
Brno, 2006. s. 283-284. [XXX. Brněnské onkologické dny s XX. Konferencí pro sestry a laboranty. 11.05.2006-13.5.2006, Brno] Institutional research plan: CEZ:AV0Z50040507 Keywords : prostate cancer * tubulin * tyrosination/detyrosination cycle Subject RIV: BO - Biophysics
Serum prostatic acid phosphatase (PAP) level was determined by radioimmunoassay (RIA) in 272 patients. For comparative purposes PAP was also measured by an enzymatic assay. In prostate adenocarcinoma 55% of the values were elevated. In early stages (A and B) 17% of patients were found to be positive; at later stages (C and D) the percentage increased to 78%. The enzymatic method yielded 46% positive values in these patients: 17% in the former group (A+B), and 64% in the latter one (C+D). False positive values were observed in 10% of the patients with prostate adenoma, and 22% of the patients with prostatis. The data confirm the low sensitivity of RIA (and enzymatic assay) for detecting early intracapsular disease. RIA determination of PAP is a good diagnostic tool for advanced cancer of the prostate. (author)
Fytoestrogeny jsou v posledních letech velice intenzivně studovány, protože vykazují rozličné farmakologické účinky na zdraví člověka. Bylo např. prokázáno, že fytoestrogeny snižují riziko výskytu některých typů rakoviny (prsu, prostaty nebo střeva), působí v organismu jako antioxidanty a ovlivňují aktivitu některých enzymů. Kromě toho byla prokázána také řada pozitivních účinků sójových fytoestrogenů na zdravotní stav žen v menopauze, jako je např. snížení rizika kardiovaskulárních onemocněn...
王超奇; 田玉英; 王金花; 梁姗; 梁静; 王璠; 王明; 余大海
目的:探讨凋亡相关蛋白Clusterin、p27和Survivin在前列腺癌组织中的表达及临床意义.方法:应用免疫组织化学方法检测68例前列腺癌组织和47例前列腺增生组织Clusterin、p27和Survivin蛋白的表达.结果:前列腺癌组织Clusterin、p27和Survivin蛋白的阳性表达率分别为75.0％ (51/68)、72.1％(49/68)和67.6％ (46/68)；前列腺增生组织Clusterin、p27和Survivin蛋白的阳性表达率分别为25.5％(12/47)、19.1％ (9/47)和23.4％ (11/47).Clusterin、p27和Survivin蛋白阳性表达率在前列腺癌组织和前列腺增生组织中差异有统计学意义,P＜0.01.Clusterin、p27和Survivin 蛋白表达与前列腺癌病理分级、临床分期和转移情况具有相关性,P＜0.05.前列腺癌组织Survivin与Clusterin、Survivin与p27的表达呈正相关,P＜0.01.结论:联合检测Clusterin、p27和Survivin蛋白有助于对进展性前列腺癌细胞的侵袭力作出正确评价,以指导临床治疗.%OBJECTIVE : To detect the expressions of Clusterin, p27, Survivin and their correlation In prostate cancer (PCa) tissues. METHODS: Immunohistochemistry was employed to measure the expression of Clusterin,p27 and Survivin in prostatic cancer and 47 cases benign prostatic hyperplasia. RESULTS: In prostatie cancer tissue, the positive expression rates of Clusterin,p27 and Survivin were 75. 0%(51/68) ,72.1%(49/68) and 67. 6％(46/68). In benign prostatic hyper-pksia tissue the positive expression rates of Clusterin, p27 and Survivin were 25. 5% (12/47) ,19, 1% (9/47), 23. 4% (11/47). The positive expression of clusterin,p27 and Survivin between prostatic cancer and benign prostatic hyperplasia were significantly different (P<0.01). The positive expression of Clusterin,p27 and Survivin were related with the histo-logic grade,clinical stage and metastasis of prostatic cancer (P<0. 05). The expression of Surrivin was a positive correlation with clusterin and p27 expression in prostatic cancer (P<0, 01
张志甫; 吴春磊; 陆铮; 莫曾南
Objective To investigate the relationship between asymptomatic inflammatory prostatitis (AIP)and serum prostate specific antigen (PSA). Methods Data collection was conducted in the Medical Examination Centre of Fangchenggang First People's Hospital.During the physical examination,trained physi-cians administered a standard questionnaire,basic data including National Institutes of Health Chronic Prostati-tis Symptom Index (NIH-CPSI),demographic information (age,education,occupation,etc),history of dis-ease,and lifestyle risk factors (smoking,alcohol consumption,and physical activity),and health status were collected using a standardized questionnaire.A trained profession conducted the anthtopometric parameters measurements for the participants.8 h-fasting vein blood was drawn and then the biochemical indexes [PSA, triglyceride (TG),high density cholesterol-cholesterol (HDL-C),and fasting blood glucose]were meas-ured.The expressed prostatic secretions (EPS)were collected and then were smeared on a glass slide for counting the mean WBC count of EPS.According to the NIH-CPSI score,and presence of inflammation,the participants were divided into a NIH-IV prostatitis group and a healthy group. Results The mean value of serum PSA in the healthy group and the NIH-IV prostatitis group were 0.91 ng/ml and 1.27 ng/ml,the standard deviation was 0.79 ng/ml,and 1.52 ng/ml,there were statistically significant differences (P <0.001).In NIH-IV prostatitis group,the scores of age,TG,diastolic blood pressure (DBP),systolic blood pressure (SBP),hypertension,education status,physical activity were higher than those in the healthy group. NIH-IV prostatitis (WBC≥3+)group compared to healthy group,along with the elevated PSA the OR value was also increased,the OR value was 1.078,3.589,4.406,respectively.In PSAQ4,with the elevation of in-flammation the OR value also increased.Respectively in age,education status,dyslipidemia,diabetes,high blood pressure
Dosagem e correlação do antígeno prostático específico com as alterações histológicas dos anexos sexuais do hamster sírio Prostate specific antigen-psa dosage and correlation with syrian hamster sexual addiction histologic alterations
Dimas José Araújo Vidigal
relações estatísticas entre os níveis de PSA e as alterações das vesículas seminais e testículo. CONCLUSÕES: 1- O Hamster Sírio, Mesocricetus auratus, apresenta PSA sérico dosável e seu valor médio para o Hamster jovem é de 0,252ng/mL e no Hamster adulto é de 0,325ng/mL.2. Não foi possível correlacionar os níveis de PSA com as alterações histológicas encontradas nos anexos sexuais do Mesocricetus auratus.BACKGROUND: The objective of this work is to verify total PSA in young and adult Syrian Hamster and demonstrate a possible correlation among those levels and sexual anexes histological changes: prostate, seminal vesicles and testicles. METHODS: On this experimental study ten young Hamsters were used, with ages below seven weeks, and twenty animals with age above one year. PSA dosage and a histological analysis of sexual anexes were performed in both groups in order to get the correlation among the PSA level and histological changes. RESULTS: The average age for young animals (control group was 46.7 days (Std Dev=1.16. In adult animals (experimental group the average age was undetermined, although all groups were above one year old, at the death moment. Average weigh of those young animals, when dead, was 57.0g (Std Dev= 3.5 and adult animals 126.5g (Std Dev=19.3 being acceptable. PSA was dosed in old adult animals plasma and in seven of the youngest ones. PSA was not detected in three animals of young group. Young animals PSA average was 0.252ng/mL (nanogran per mililiter and in adults some presented 0.325ng/mL. Young animals did not present histologic changes. In adult hamsters, fourteen (70.0% of them presented change in their sexual anexes: ten (50.0% PBH (prostate benign hiperplasia, one (5.0% HBP, prostatis and seminal vesicle inflammation, one (5.0% seminal vesicle suppurative inflammation, one (5.0% testicle infarct and prostatitis. There was no statistic relationship between PSA levels and PBH, although those with PBH evidenced PSA higher