Block Pickard Models for Two-Dimensional Constraints
Forchhammer, Søren; Justesen, Jørn
2009-01-01
In Pickard random fields (PRF), the probabilities of finite configurations and the entropy of the field can be calculated explicitly, but only very simple structures can be incorporated into such a field. Given two Markov chains describing a boundary, an algorithm is presented which determines wh...... domino tiling constraint represented by a quaternary alphabet. PRF models are also presented for higher order constraints, including the no isolated bits (n.i.b.) constraint, and a minimum distance 3 constraint by defining super symbols on blocks of binary symbols....
A Model for the Two-dimensional no Isolated Bits Constraint
Forchhammer, Søren; Laursen, Torben Vaarby
2006-01-01
A stationary model is presented for the two-dimensional (2-D) no isolated bits (n.i.b.) constraint over an extended alphabet defined by the elements within 1 by 2 blocks. This block-wise model is based on a set of sufficient conditions for a Pickard random field (PRF) over an m-ary alphabet...
Block clustering with collapsed latent block models
Wyse, Jason; Friel, Nial
2010-01-01
We introduce a Bayesian extension of the latent block model for model-based block clustering of data matrices. Our approach considers a block model where block parameters may be integrated out. The result is a posterior defined over the number of clusters in rows and columns and cluster memberships. The number of row and column clusters need not be known in advance as these are sampled along with cluster memberhips using Markov chain Monte Carlo. This differs from existing work on latent bloc...
A series of models is being built and used as tools in the design of the SNUPPS Standard Power Block. The modelling programme includes both preliminary and final design models, a construction sequence mode, and additional models used to study various features of the design. The design of a standard power block unit has necessitated design definition which is more detailed than that customarily used in the design of nuclear power stations. One innovation is the use of engineering models as a primary design tool in the layout of process piping, preparation of isometric drawings, design of small components which are customarily designed in the field during construction. Development of a standard construction sequence and construction work plan is another innovation. (author)
Sampaio, C I N
2011-01-01
We introduce and study the block voter model with noise on two-dimensional square lattices using Monte Carlo simulations and finite-size scaling techniques. The model is defined by an outflow dynamics where a central set of $N_{PCS}$ spins, here denoted by persuasive cluster spins (PCS), tries to influence the opinion of their neighbouring counterparts. We consider the collective behaviour of the entire system with varying PCS size. When $N_{PCS}>2$, the system exhibits an order-disorder phase transition at a critical noise parameter $q_{c}$ which is a monotonically increasing function of the size of the persuasive cluster. We conclude that how large the PCS is more power of persuasion it has. It also seems that the resulting critical behaviour is Ising-like independent of the range of the interactions.
Multi-block and path modelling procedures
Høskuldsson, Agnar
2008-01-01
of sub-processes, overall model can be specified. There can be several useful path models during the process, where the data blocks in a path are the ones that are actual or important at given stages of the process. Data collection equipments are getting more and more advanced and cheap. Data analysis...... that lead to it. Methods of standard regression analysis are extended to this type of modelling. Three types of 'strengths' of relationship are computed for each set of two connected data blocks. First is the strength in the path, second the strength where only the data blocks leading to the last one...
Extensions to the two atom blocking model
This paper contains viewgraphs on the use of the blocking model to describe atom-atom collisions in solids. Experimental results on two particle emissions for attractive and repulsive coulomb potentials are given
Mineral resources estimation based on block modeling
Bargawa, Waterman Sulistyana; Amri, Nur Ali
2016-02-01
The estimation in this paper uses three kinds of block models of nearest neighbor polygon, inverse distance squared and ordinary kriging. The techniques are weighting scheme which is based on the principle that block content is a linear combination of the grade data or the sample around the block being estimated. The case study in Pongkor area, here is gold-silver resource modeling that allegedly shaped of quartz vein as a hydrothermal process of epithermal type. Resources modeling includes of data entry, statistical and variography analysis of topography and geological model, the block model construction, estimation parameter, presentation model and tabulation of mineral resources. Skewed distribution, here isolated by robust semivariogram. The mineral resources classification generated in this model based on an analysis of the kriging standard deviation and number of samples which are used in the estimation of each block. Research results are used to evaluate the performance of OK and IDS estimator. Based on the visual and statistical analysis, concluded that the model of OK gives the estimation closer to the data used for modeling.
Spring-block Model for Barkhausen Noise
A simple mechanical spring-block model is used for studying Barkhausen noise (BN). The model incorporates the generally accepted physics of domain wall movement and pinning. Computer simulations on this model reproduces the main features of the hysteresis loop and Barkhausen jumps. The statistics of the obtained Barkhausen jumps follows several scaling laws, in qualitative agreement with experimental results. The model consists of a one-dimensional frictional spring-block system. The blocks model the Bloch-walls that separate inversely oriented magnetic domains, and springs correspond to the magnetized regions. Three types of realistic forces are modelled with this system: 1. the force resulting from the magnetic energy of the neighboring domains in external magnetic field (modelled by forces having alternating orientations and acting directly on the blocks); 2. the force resulting from the magnetic self-energy of each domain (modelled by the elastic forces of the springs); 3. the pinning forces acting on the domain walls (modelled by position dependent static friction acting on blocks). The dynamics of the system is governed by searching for equilibrium: one particular domain wall can jump to the next pinning center if the resultant of forces 1. and 2. is greater then the pinning force. The external magnetic field is successively increased (or decreased) and the system is relaxed to mechanical equilibrium. During the simulations we are monitoring the variation of the magnetization focusing on the shape of the hysteresis loop, power spectrum, jump size (avalanche size) distribution, signal duration distribution, signal area distribution. The simulated shape of the hysteresis loops fulfills all the requirements for real magnetization phenomena. The power spectrum indicates different behavior in the low (1/f noise) and high (white noise) frequency region. All the relevant distribution functions show scaling behavior over several decades of magnitude with a naturally
Høskuldsson, Agnar; Svinning, K.
2006-01-01
Here is presented a unified approach to modelling multi-block regression data. The starting point is a partition of the data X into L data blocks, X = (X-1, X-2,...X-L), and the data Y into M data-blocks, Y = (Y-1, Y-2,...,Y-M). The methods of linear regression, X -> Y, are extended to the case...... of a linear relationship between each X-i and Y-j. X-i -> Y-j. A modelling strategy is used to decide if the residual X-i should take part in the modelling of one or more Y(j)s. At each step the procedure of finding score vectors is based on well-defined optimisation procedures. The principle of optimisation...... is based on that the score vectors should give the sizes of the resulting Y(j)s loading vectors as large as possible. The partition of X and Y are independent of each other. The choice of Y-j can be X-j, Y-i = X-i, thus including the possibility of modelling X -> X-i,i=1,...,L. It is shown how...
Infinite-degree-corrected stochastic block model
Herlau, Tue; Schmidt, Mikkel Nørgaard; Mørup, Morten
2014-01-01
, Phys. Rev. E 83, 016107 (2011)] incorporates a node degree correction to model degree heterogeneity within each group. Although this demonstrably leads to better performance on several networks, it is not obvious whether modeling node degree is always appropriate or necessary. We formulate the degree...... corrected stochastic block model as a nonparametric Bayesian model, incorporating a parameter to control the amount of degree correction that can then be inferred from data. Additionally, our formulation yields principled ways of inferring the number of groups as well as predicting missing links in the...... network that can be used to quantify the model’s predictive performance. On synthetic data we demonstrate that including the degree correction yields better performance on both recovering the true group structure and predicting missing links when degree heterogeneity is present, whereas performance is on...
Inverse modeling of Chalk River block
Within the framework of the international project HYDROCOIN, a block of fractured monzonitic gneiss within the facilities of Chalk River National Laboratories, Canada, was selected as a test case to study and develop strategies for the calibration and validation of groundwater flow models. Adopting a quasi-three dimensional formulation, the fractures were simulated by two-dimensional finite elements and the rock mass was simulated by strings of line elements. The models were calibrated using, first, steady-state data and, second, transient data. Model calibration involved both identification of model parameters and model structure. Model parameters were obtained by automatic estimation based on measures of the model response and prior information about the model parameters. Excellent agreement between measured and computed heads was obtained for the transient runs. However, such match was only fair in steady-state. Model Structures Identification criteria were used to rank the performance of several model structures. In the steady state the model structure identification criteria did not strongly support increasing the model complexity. However, it is also believed that the information content of the steady state data was quite poor. In contrast, the transient data being both more numerous and more informative than steady-state data, allowed the model structure identification criteria to suggest more complex models. The validation runs were performed on data corresponding to interference pump tests different from the ones used for calibration. The prediction errors in these runs were relatively small and consistent with the calibration uncertainty. Furthermore, the ranking of the models performances during validation runs was the same as the one obtained at the calibration stage, using Model Structure Identification Criteria. (author) 26 figs., 17 tabs., 39 refs
Block Models and Personalized PageRank
Kloumann, Isabel; Kleinberg, Jon
2016-01-01
Methods for ranking the importance of nodes in a network have a rich history in machine learning and across domains that analyze structured data. Recent work has evaluated these methods though the seed set expansion problem: given a subset $S$ of nodes from a community of interest in an underlying graph, can we reliably identify the rest of the community? We start from the observation that the most widely used techniques for this problem, personalized PageRank and heat kernel methods, operate in the space of landing probabilities of a random walk rooted at the seed set, ranking nodes according to weighted sums of landing probabilities of different length walks. Both schemes, however, lack an a priori relationship to the seed set objective. In this work we develop a principled framework for evaluating ranking methods by studying seed set expansion applied to the stochastic block model. We derive the optimal gradient for separating the landing probabilities of two classes in a stochastic block model, and find, ...
Optimal information diffusion in stochastic block models
Curato, Gianbiagio
2016-01-01
We use the linear threshold model to study the diffusion of information on a network generated by the stochastic block model. We focus our analysis on a two community structure where the initial set of informed nodes lies only in one of the two communities and we look for optimal network structures, i.e. those maximizing the asymptotic extent of the diffusion. We find that, constraining the mean degree and the fraction of initially informed nodes, the optimal structure can be assortative (modular), core-periphery, or even disassortative. We then look for minimal cost structures, i.e. those such that a minimal fraction of initially informed nodes is needed to trigger a global cascade. We find that the optimal networks are assortative but with a structure very close to a core-periphery graph, i.e. a very dense community linked to a much more sparsely connected periphery.
Block Kalman filtering for large-scale DSGE models
Strid, Ingvar; Walentin, Karl
2008-01-01
In this paper block Kalman filters for Dynamic Stochastic General Equilibrium models are presented and evaluated. Our approach is based on the simple idea of writing down the Kalman filter recursions on block form and appropriately sequencing the operations of the prediction step of the algorithm. It is argued that block filtering is the only viable serial algorithmic approach to significantly reduce Kalman filtering time in the context of large DSGE models. For the largest model we evaluate ...
Latent Block Model for Contingency Table
Govaert, Gérard; Nadif, Mohamed
2010-01-01
Although many clustering procedures aim to construct an optimal partition of objects or, sometimes, variables, there are other methods, called block clustering methods, which simultaneously consider the two sets and organize the data into homogeneous blocks. This kind of method has practical importance in a wide variety of applications such as text and market basket data analysis. Typically, the data that arise in these applications are arranged as a two-way contingency table. Using Poisson d...
Block Mixture Model for the Biclustering of Microarray Data
Ben Saber, Haifa; Elloumi, Mourad; Nadif, Mohamed
2011-01-01
An attractive way to make biclustering of genes and conditions is to adopt a Block Mixture Model (BMM). Approaches based on a BMM operate thanks to a Block Expectation Maximization (BEM) algorithm and/or a Block Classification Expectation Maximization (BCEM) one. The drawback of these approaches is their difficulty to choose a good strategy of initialization of the BEM and BCEM algorithms. This paper introduces existing biclustering approaches adopting a BMM and suggests a new fuzzy bicluster...
Big Blocks and River Incision: A Numerical Modeling Perspective
Shobe, C. M.; Tucker, G. E.; Anderson, R. S.
2015-12-01
Sediment supply dynamics affect fluvial erosion in steep landscapes. Workers have explored the effects of changing sediment flux and uniform grain size on incision processes and distribution of alluvial cover. However, sediment supplied to real rivers is often highly heterogeneous in size, especially in rapidly eroding landscapes where supply processes may range from landslides to rockfall to moraine incision. We hypothesize that the pace of landscape evolution depends on the sediment size distribution supplied to rapidly eroding channels. Rivers that quickly cut steep-walled canyons may incite a negative feedback on incision by receiving an increased supply of large, immobile blocks from the canyon walls that shield significant portions of the bed from erosion. We use a 1-D numerical model that combines mass-flux continuum treatment of several grain size classes with tracking of discrete large blocks to explore fluvial response to changing grain size distribution. We compare simulations with and without a feedback between channel incision rate and the supply rate of large blocks from adjacent hillslopes. This reflects the hypothesis that slopes will be steeper and more prone to releasing large blocks when the channel at their base is eroding rapidly. Comparing model predictions with field observations shows that our models can successfully reproduce the distribution of blocks in natural channels. Results suggest that in landscapes with access to large blocks, fluvial incision may be slowed as increasing amounts of immobile material are supplied from adjacent hillslopes and canyon walls. This can act to stall knickpoint retreat in such rivers and slow the pace of landscape adjustment. The importance of channel armoring by blocks is governed by competition between two timescales: the time required for significant block cover to accumulate in the channel and the time required for blocks to abrade, fragment, or weather down to transportable sizes. Model results also
Efficient image duplicated region detection model using sequential block clustering
Sekeh, M. A.; Maarof, M. A.; Rohani, M. F.; Mahdian, Babak
2013-01-01
Roč. 10, č. 1 (2013), s. 73-84. ISSN 1742-2876 Institutional support: RVO:67985556 Keywords : Image forensic * Copy–paste forgery * Local block matching Subject RIV: IN - Informatics, Computer Science Impact factor: 0.986, year: 2013 http://library.utia.cas.cz/separaty/2013/ZOI/mahdian-efficient image duplicated region detection model using sequential block clustering.pdf
Extending models for two-dimensional constraints
Forchhammer, Søren
2009-01-01
Random fields in two dimensions may be specified on 2 times 2 elements such that the probabilities of finite configurations and the entropy may be calculated explicitly. The Pickard random field is one example where probability of a new (non-boundary) element is conditioned on three previous...... models of two-dimensional constraints and as examples we apply it to the hard-square constraint and the no isolated bits (n.i.b) constraint. The iterative scaling can ensure that the entropy of the extension is optimized and that the entropy is increased compared to the initial model defined on 2 times 2...... elements. Application to a simple stationary model with hidden states is also outlined. For the n.i.b constraint, the initial model is based on elements defined by blocks of (1 times 2) binary symbols....
MODELS FOR EMBEDDED REPAIRING LOGIC BLOCKS
Hahanov, V. I.; Abbas, Murad Ali; Litvinova, E.I.; HAHANOVA I.V.
2013-01-01
The goal of this article is to improve the quality and reliability of digital systems-on-chips by creating an infrastructure for embedded testing, diagnosis, optimization and repairing through the use of hardware redundancy and reduce the speed of functional operations. The models of combinational circuits, focused on solving real-world problems of embedded repairing components of the logic devices, are proposed. The logical scheme is improved by using operational and control automaton for mo...
Block Spin Density Matrix of the Inhomogeneous AKLT Model
Xu, Ying; Katsura, Hosho; Hirano, Takaaki; Korepin, Vladimir E.
2008-01-01
We study the inhomogeneous generalization of a 1-dimensional AKLT spin chain model. Spins at each lattice site could be different. Under certain conditions, the ground state of this AKLT model is unique and is described by the Valence-Bond-Solid (VBS) state. We calculate the density matrix of a contiguous block of bulk spins in this ground state. The density matrix is independent of spins outside the block. It is diagonalized and shown to be a projector onto a subspace. We prove that for larg...
Block-Krylov component synthesis method for structural model reduction
Craig, Roy R., Jr.; Hale, Arthur L.
1988-01-01
A new analytical method is presented for generating component shape vectors, or Ritz vectors, for use in component synthesis. Based on the concept of a block-Krylov subspace, easily derived recurrence relations generate blocks of Ritz vectors for each component. The subspace spanned by the Ritz vectors is called a block-Krylov subspace. The synthesis uses the new Ritz vectors rather than component normal modes to reduce the order of large, finite-element component models. An advantage of the Ritz vectors is that they involve significantly less computation than component normal modes. Both 'free-interface' and 'fixed-interface' component models are derived. They yield block-Krylov formulations paralleling the concepts of free-interface and fixed-interface component modal synthesis. Additionally, block-Krylov reduced-order component models are shown to have special disturbability/observability properties. Consequently, the method is attractive in active structural control applications, such as large space structures. The new fixed-interface methodology is demonstrated by a numerical example. The accuracy is found to be comparable to that of fixed-interface component modal synthesis.
A block-based landslide model using smooth surface reconstructions
Elsen, Katharina; Tinti, Stefano
2014-05-01
The present work is combining the block-based landslide-model developed by Tinti and Bertolucci (2000) with different smooth surface reconstruction methods. This enables us to directly solve the underlying ODE-system, that is describing the blocks motion, numerically. The numerical model is based on the idea that the sliding mass can be discretized by a certain number of quadrilateral blocks of finite volume, where the movement of the single blocks is described using a Lagrangian approach. Within this approach, the underlying equations of motion require for each time-step the computation of the acceleration of each of the blocks from their position on the sliding surface, where information on its curvature is needed in order to compute the centripetal component. To come up to this, different methods were used to interpolate smooth, two times differentiable, surface reconstructions from a given number of points that are describing the real sliding surface. The numerical solution of the model in time is obtained using higher-order explicit and implicit time-integration methods The results of the simulations are evaluated especially with respect to the arrival times and final velocities of the sliding mass and therefore a possible tsunamigenic impact.
Detection Block Model for SQL Injection Attacks
Diksha G. Kumar
2014-10-01
Full Text Available With the rapid development of Internet, more and more organizations connect their databases to the Internet for resource sharing. However, due to developers' lack of knowledge of all possible attacks, web applications become vulnerable to multiple attacks. Thus the network databases could face multiple threats. Web applications generally consist of a three tier architecture where database is in the third pole, which is the most valuable asset in any organization. SQL injection is an attack technique in which specially crafted input string is entered in user input field. It is submitted to server and result is returned to the user. In SQL injection vulnerability, the database server is forced to execute malicious operations which may cause the data loss or corruption, denial of access, and unauthentic access to sensitive data by crafting specific inputs. An attacker can directly compromise the database, and that is why this is a most threatening web attack. SQL injection attack occupies first position in top ten vulnerabilities as specified by Open Web Application Security Project. It is probably the most common Website vulnerability today. Current scenarios which provide solutions to SQL injection attack either have limited scope i.e. can’t be implemented across all platforms, or do not cover all types of SQL injection attacks. In this work we implement Message Authentication Code (MAC based solution against SQL injection attacks. The model works both on client and server side. Client side implements a filter function and server side is based on information theory. MAC of static and dynamic queries is compared to detect SQL injection attack.
A physical model for measuring thermally-induced block displacements
Bakun-Mazor, Dagan; Feldhiem, Aviran; Keissar, Yuval; Hatzor, Yossef H.
2016-04-01
A new model for thermally-induced block displacement in discontinuous rock slopes has been recently suggested. The model consists of a discrete block that is separated from the rock mass by a tension crack and rests on an inclined plane. The tension crack is filled with a wedge block or rock fragments. Irreversible block sliding is assumed to develop in response to climatic thermal fluctuations and consequent contraction and expansion of the sliding block material. While a tentative analytical solution for this model is already available, we are exploring here the possibility of obtaining such a permanent, thermally-induced, rock block displacement, under fully controlled conditions at the laboratory, and the sensitivity of the mechanism to geometry, mechanical properties, and temperature fluctuations. A large scale concrete physical model (50x150x60 cm^3) is being examined in a Climate-Controlled Room (CCR). The CCR permits accurate control of ambient temperature from 5 to 45 Celsius degrees. The permanent plastic displacement is being measured using four displacement transducers and a high resolution (29M pixel) visual range camera. A series of thermocouples measure the heating front inside the sliding block, hence thermal diffusivity is evaluated from the measured thermal gradient and heat flow. In order to select the appropriate concrete mixture, the mechanical and thermo-physical properties of concrete samples are determined in the lab. Friction angle and shear stiffness of the sliding interface are determined utilizing a hydraulic, servo-controlled direct shear apparatus. Uniaxial compression tests are performed to determine the uniaxial compressive strength, Young's modulus and Poison's ratio of the intact block material using a stiff triaxial load frame. Thermal conductivity and linear thermal expansion coefficient are determined experimentally using a self-constructed measuring system. Due to the fact that this experiment is still in progress, preliminary
Analogue Behavioral Modeling of Switched-Current Building Block Circuits
ZENG Xuan; WANG Wei; SHI Jianlei; TANG Pushan; D.ZHOU
2001-01-01
This paper proposes a behavioral modeling technique for the second-generation switched-current building block circuits. The proposed models are capable of capturing the non-ideal behavior of switched-current circuits, which includes the charge injection effects and device mismatch effects. As a result, system performance degradations due to the building block imperfections can be detected at the early design stage by fast behavioral simulations. To evaluate the accuracy of the proposed models, we developed a time-domain behavioral simulator. Experimental results have shown that compared with SPICE, the behavioral modeling error is less than 2.15%, while behavioral simulation speed up is 4 orders in time-domain.
A biologically inspired computational model of the Block Copying Task
Lan, Tian; Arnold, Michael; Sejnowski, Terrence; Jabri, Marwan
2003-01-01
We present in this paper a biologically inspired model of the Basal Ganglia which deals with Block Copying as a sequence learning task. By breaking a relatively complex task into simpler operations with well-defined skills, an approach which is termed as a skill-based machine design is used in the device of computational models to complete such tasks. Basal Ganglia are critically involved in sensorimotor control. From the learning aspects, Actor-Critic architectures have been proposed to mode...
Global and Local Information in Clustering Labeled Block Models
Kanade, Varun; Mossel, Elchanan; Schramm, Tselil
2014-01-01
The stochastic block model is a classical cluster-exhibiting random graph model that has been widely studied in statistics, physics and computer science. In its simplest form, the model is a random graph with two equal-sized clusters, with intra-cluster edge probability p, and inter-cluster edge probability q. We focus on the sparse case, i.e., p, q = O(1/n), which is practically more relevant and also mathematically more challenging. A conjecture of Decelle, Krzakala, Moore and Zdeborova, ba...
Mathematical modeling and simulation of nanopore blocking by precipitation
Wolfram, M-T
2010-10-29
High surface charges of polymer pore walls and applied electric fields can lead to the formation and subsequent dissolution of precipitates in nanopores. These precipitates block the pore, leading to current fluctuations. We present an extended Poisson-Nernst-Planck system which includes chemical reactions of precipitation and dissolution. We discuss the mathematical modeling and present 2D numerical simulations. © 2010 IOP Publishing Ltd.
Mixed-Membership Stochastic Block-Models for Transactional Networks
Shafiei, Mahdi
2010-01-01
Transactional network data can be thought of as a list of one-to-many communications(e.g., email) between nodes in a social network. Most social network models convert this type of data into binary relations between pairs of nodes. We develop a latent mixed membership model capable of modeling richer forms of transactional network data, including relations between more than two nodes. The model can cluster nodes and predict transactions. The block-model nature of the model implies that groups can be characterized in very general ways. This flexible notion of group structure enables discovery of rich structure in transactional networks. Estimation and inference are accomplished via a variational EM algorithm. Simulations indicate that the learning algorithm can recover the correct generative model. Interesting structure is discovered in the Enron email dataset and another dataset extracted from the Reddit website. Analysis of the Reddit data is facilitated by a novel performance measure for comparing two soft ...
Application of blocking diagnosis methods to general circulation models. Part II: model simulations
Barriopedro, D.; Trigo, R.M. [Universidade de Lisboa, CGUL-IDL, Faculdade de Ciencias, Lisbon (Portugal); Garcia-Herrera, R.; Gonzalez-Rouco, J.F. [Universidad Complutense de Madrid, Departamento de Fisica de la Tierra II, Facultad de C.C. Fisicas, Madrid (Spain)
2010-12-15
A previously defined automatic method is applied to reanalysis and present-day (1950-1989) forced simulations of the ECHO-G model in order to assess its performance in reproducing atmospheric blocking in the Northern Hemisphere. Unlike previous methodologies, critical parameters and thresholds to estimate blocking occurrence in the model are not calibrated with an observed reference, but objectively derived from the simulated climatology. The choice of model dependent parameters allows for an objective definition of blocking and corrects for some intrinsic model bias, the difference between model and observed thresholds providing a measure of systematic errors in the model. The model captures reasonably the main blocking features (location, amplitude, annual cycle and persistence) found in observations, but reveals a relative southward shift of Eurasian blocks and an overall underestimation of blocking activity, especially over the Euro-Atlantic sector. Blocking underestimation mostly arises from the model inability to generate long persistent blocks with the observed frequency. This error is mainly attributed to a bias in the basic state. The bias pattern consists of excessive zonal winds over the Euro-Atlantic sector and a southward shift at the exit zone of the jet stream extending into in the Eurasian continent, that are more prominent in cold and warm seasons and account for much of Euro-Atlantic and Eurasian blocking errors, respectively. It is shown that other widely used blocking indices or empirical observational thresholds may not give a proper account of the lack of realism in the model as compared with the proposed method. This suggests that in addition to blocking changes that could be ascribed to natural variability processes or climate change signals in the simulated climate, attention should be paid to significant departures in the diagnosis of phenomena that can also arise from an inappropriate adaptation of detection methods to the climate of the
New Kinematic Block Model for the Caribbean Plate
Symithe, S. J.; Calais, E.; Freed, A. M.
2013-12-01
The quasi-frontal subduction of the north and south American plates under the Lesser Antilles and the left- and right-lateral strike slip along the northern and southern margins of the Caribbean plate offer the opportunity to study the transition from subduction to strike-slip faulting along major plate boundaries. In addition, the segmentation and degree of interplate coupling along the Lesser Antilles subduction is key to our understanding of the earthquake potential of a subduction zone whose length is similar to the rupture area of the Mw9.0, 2011, Tohoku earthquake in Japan. Previous studies used GPS data and a block modeling approach to infer coupling at the plate interface and strain partitioning at the transition with strike-slip fault in the northeastern Caribbean (Manaker et al., 2008; Benford et al., 2013), with three main findings: (1) a correlation between strong interplate coupling and strain partitioning, (2) low coupling of the Lesser Antilles and Puerto Rico subduction, and, (3) internal deformation within the upper plate in Hispaniola. These studies were however based on a sparse and inhomogeneous GPS data set. Here we use a much updated geodetic GPS data set (~300 stations, 50% continuous) and earthquake slip vectors to expand these previous studies to the entire Caribbean region (excluding Central America, except to define the stable Caribbean plate). We use the block modeling approach described in McCaffrey et al. (2002) to test the optimal block geometry for the northern, eastern and southern boundaries of the Caribbean plate. We solve for variations in interplate coupling along the subduction plate boundaries, estimate angular velocities for each block/plate, and determine strain accumulation rates for all major faults in the region.
Energy Blocks — A Physical Model for Teaching Energy Concepts
Hertting, Scott
2016-01-01
Most physics educators would agree that energy is a very useful, albeit abstract topic. It is therefore important to use various methods to help the student internalize the concept of energy itself and its related ideas. These methods include using representations such as energy bar graphs, energy pie charts, or energy tracking diagrams. Activities and analogies like Energy Theater and Richard Feynman's blocks, as well as the popular money (or wealth) analogy, can also be very effective. The goal of this paper is to describe a physical model of Feynman's blocks that can be employed by instructors to help students learn the following energy-related concepts: 1. The factors affecting each individual mechanical energy storage mode (this refers to what has been traditionally called a form of energy, and while the Modeling Method of instruction is not the focus of this paper, much of the energy related language used is specific to the Modeling Method). For example, how mass or height affects gravitational energy; 2. Energy conservation; and 3. The graphical relationships between the energy storage mode and a factor affecting it. For example, the graphical relationship between elastic energy and the change in length of a spring.
Ecohydrologic process modeling of mountain block groundwater recharge.
Magruder, Ian A; Woessner, William W; Running, Steve W
2009-01-01
Regional mountain block recharge (MBR) is a key component of alluvial basin aquifer systems typical of the western United States. Yet neither water scientists nor resource managers have a commonly available and reasonably invoked quantitative method to constrain MBR rates. Recent advances in landscape-scale ecohydrologic process modeling offer the possibility that meteorological data and land surface physical and vegetative conditions can be used to generate estimates of MBR. A water balance was generated for a temperate 24,600-ha mountain watershed, elevation 1565 to 3207 m, using the ecosystem process model Biome-BGC (BioGeochemical Cycles) (Running and Hunt 1993). Input data included remotely sensed landscape information and climate data generated with the Mountain Climate Simulator (MT-CLIM) (Running et al. 1987). Estimated mean annual MBR flux into the crystalline bedrock terrain is 99,000 m(3) /d, or approximately 19% of annual precipitation for the 2003 water year. Controls on MBR predictions include evapotranspiration (radiation limited in wet years and moisture limited in dry years), soil properties, vegetative ecotones (significant at lower elevations), and snowmelt (dominant recharge process). The ecohydrologic model is also used to investigate how climatic and vegetative controls influence recharge dynamics within three elevation zones. The ecohydrologic model proves useful for investigating controls on recharge to mountain blocks as a function of climate and vegetation. Future efforts will need to investigate the uncertainty in the modeled water balance by incorporating an advanced understanding of mountain recharge processes, an ability to simulate those processes at varying scales, and independent approaches to calibrating MBR estimates. PMID:19702780
Block voter model: phase diagram and critical behavior.
Sampaio-Filho, C I N; Moreira, F G B
2011-11-01
We introduce and study the block voter model with noise on two-dimensional square lattices using Monte Carlo simulations and finite-size scaling techniques. The model is defined by an outflow dynamics where a central set of N(PCS) spins, here denoted by persuasive cluster spins (PCS), tries to influence the opinion of their neighboring counterparts. We consider the collective behavior of the entire system with varying PCS size. When N(PCS)>2, the system exhibits an order-disorder phase transition at a critical noise parameter q(c) which is a monotonically increasing function of the size of the persuasive cluster. We conclude that a larger PCS has more power of persuasion, when compared to a smaller one. It also seems that the resulting critical behavior is Ising-like independent of the range of interaction. PMID:22181394
Thin Filament Structure and the Steric Blocking Model.
Lehman, William
2016-04-01
By interacting with the troponin-tropomyosin complex on myofibrillar thin filaments, Ca2+ and myosin govern the regulatory switching processes influencing contractile activity of mammalian cardiac and skeletal muscles. A possible explanation of the roles played by Ca2+ and myosin emerged in the early 1970s when a compelling "steric model" began to gain traction as a likely mechanism accounting for muscle regulation. In its most simple form, the model holds that, under the control of Ca2+ binding to troponin and myosin binding to actin, tropomyosin strands running along thin filaments either block myosin-binding sites on actin when muscles are relaxed or move away from them when muscles are activated. Evidence for the steric model was initially based on interpretation of subtle changes observed in X-ray fiber diffraction patterns of intact skeletal muscle preparations. Over the past 25 years, electron microscopy coupled with three-dimensional reconstruction directly resolved thin filament organization under many experimental conditions and at increasingly higher resolution. At low-Ca2+, tropomyosin was shown to occupy a "blocked-state" position on the filament, and switched-on in a two-step process, involving first a movement of tropomyosin away from the majority of the myosin-binding site as Ca2+ binds to troponin and then a further movement to fully expose the site when small numbers of myosin heads bind to actin. In this contribution, basic information on Ca2+-regulation of muscle contraction is provided. A description is then given relating the voyage of discovery taken to arrive at the present understanding of the steric regulatory model. PMID:27065174
Inference for blocked randomization under a selection bias model.
Kennes, Lieven N; Rosenberger, William F; Hilgers, Ralf-Dieter
2015-12-01
We provide an asymptotic test to analyze randomized clinical trials that may be subject to selection bias. For normally distributed responses, and under permuted block randomization, we derive a likelihood ratio test of the treatment effect under a selection bias model. A likelihood ratio test of the presence of selection bias arises from the same formulation. We prove that the test is asymptotically chi-square on one degree of freedom. These results correlate well with the likelihood ratio test of Ivanova et al. (2005, Statistics in Medicine 24, 1537-1546) for binary responses, for which they established by simulation that the asymptotic distribution is chi-square. Simulations also show that the test is robust to departures from normality and under another randomization procedure. We illustrate the test by reanalyzing a clinical trial on retinal detachment. PMID:26099068
Rectangular amplitudes, conformal blocks, and applications to loop models
Bondesan, Roberto, E-mail: roberto.bondesan@cea.fr [LPTENS, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris (France); Institute de Physique Theorique, CEA Saclay, F-91191 Gif-sur-Yvette (France); Jacobsen, Jesper L. [LPTENS, Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris (France); Universite Pierre et Marie Curie, 4 place Jussieu, 75252 Paris (France); Saleur, Hubert [Institute de Physique Theorique, CEA Saclay, F-91191 Gif-sur-Yvette (France); Physics Department, USC, Los Angeles, CA 90089-0484 (United States)
2013-02-21
In this paper we continue the investigation of partition functions of critical systems on a rectangle initiated in [R. Bondesan, et al., Nucl. Phys. B 862 (2012) 553-575]. Here we develop a general formalism of rectangle boundary states using conformal field theory, adapted to describe geometries supporting different boundary conditions. We discuss the computation of rectangular amplitudes and their modular properties, presenting explicit results for the case of free theories. In a second part of the paper we focus on applications to loop models, discussing in details lattice discretizations using both numerical and analytical calculations. These results allow to interpret geometrically conformal blocks, and as an application we derive new probability formulas for self-avoiding walks.
Martin Boeff
2014-01-01
Full Text Available The plastic deformations of tempered martensite steel representative volume elements with different martensite block structures have been investigated by using a nonlocal crystal plasticity model which considers isotropic and kinematic hardening produced by plastic strain gradients. It was found that pronounced strain gradients occur in the grain boundary region even under homogeneous loading. The isotropic hardening of strain gradients strongly influences the global stress–strain diagram while the kinematic hardening of strain gradients influences the local deformation behaviour. It is found that the additional strain gradient hardening is not only dependent on the block width but also on the misorientations or the deformation incompatibilities in adjacent blocks.
Consistency of community detection in networks under degree-corrected stochastic block models
Zhao, Yunpeng; Levina, Elizaveta; Zhu, Ji
2012-01-01
Community detection is a fundamental problem in network analysis, with applications in many diverse areas. The stochastic block model is a common tool for model-based community detection, and asymptotic tools for checking consistency of community detection under the block model have been recently developed. However, the block model is limited by its assumption that all nodes within a community are stochastically equivalent, and provides a poor fit to networks with hubs or highly varying node ...
When is Nontrivial Estimation Possible for Graphons and Stochastic Block Models?
McMillan, Audra; Smith, Adam, 1723-1790
2016-01-01
Block graphons (also called stochastic block models) are an important and widely-studied class of models for random networks. We provide a lower bound on the accuracy of estimators for block graphons with a large number of blocks. We show that, given only the number $k$ of blocks and an upper bound $\\rho$ on the values (connection probabilities) of the graphon, every estimator incurs error at least on the order of $\\min(\\rho, \\sqrt{\\rho k^2/n^2})$ in the $\\delta_2$ metric with constant probab...
Clinic expert information extraction based on domain model and block importance model.
Zhang, Yuanpeng; Wang, Li; Qian, Danmin; Geng, Xingyun; Yao, Dengfu; Dong, Jiancheng
2015-11-01
To extract expert clinic information from the Deep Web, there are two challenges to face. The first one is to make a judgment on forms. A novel method based on a domain model, which is a tree structure constructed by the attributes of query interfaces is proposed. With this model, query interfaces can be classified to a domain and filled in with domain keywords. Another challenge is to extract information from response Web pages indexed by query interfaces. To filter the noisy information on a Web page, a block importance model is proposed, both content and spatial features are taken into account in this model. The experimental results indicate that the domain model yields a precision 4.89% higher than that of the rule-based method, whereas the block importance model yields an F1 measure 10.5% higher than that of the XPath method. PMID:26231612
Auditory Model: Effects on Learning under Blocked and Random Practice Schedules
Han, Dong-Wook; Shea, Charles H.
2008-01-01
An experiment was conducted to determine the impact of an auditory model on blocked, random, and mixed practice schedules of three five-segment timing sequences (relative time constant). We were interested in whether or not the auditory model differentially affected the learning of relative and absolute timing under blocked and random practice.…
Markov Bases for Typical Block Effect Models of Two-way Contingency Tables
Ogawa, Mitsunori; Takemura, Akimichi
2011-01-01
Markov basis for statistical model of contingency tables gives a useful tool for performing the conditional test of the model via Markov chain Monte Carlo method. In this paper we derive explicit forms of Markov bases for change point models and block diagonal effect models, which are typical block-wise effect models of two-way contingency tables, and perform conditional tests with some real data sets.
Spring-block model for a single-lane highway traffic
Jarai-Szabo, Ferenc; Sandor, Bulcsu; Neda, Zoltan
2010-01-01
A simple one-dimensional spring-block chain with asymmetric interactions is considered to model an idealized single-lane highway traffic. The main elements of the system are blocks (modeling cars), springs with unidirectional interactions (modeling distance keeping interactions between neighbors), static and kinetic friction (modeling inertia of drivers and cars) and spatiotemporal disorder in the values of these friction forces (modeling differences in the driving attitudes). The traveling c...
On dynamics of seismicity simulated by the models of blocks-and-faults systems
I. A. Vorobieva
1997-06-01
Full Text Available The major results obtained by numerical simulation of block structure dynamics are juxtaposed and analysed: the possibilities to reconstruct tectonic driving forces from territorial distribution of seismicity, clustering of earthquakes in the model, and dependence of the occurrence of strong earthquakes on fragmentation of the media, and on rotation of blocks. These results show that modelling of block structure dynamics is a useful tool to study relations between the geometry of faults and block movements and earthquake flow, including premonitory seismicity patterns, to test the existing earthquake prediction algorithms, and to develop new ones.
Modeling of IPMC cantilever’s displacements and blocking forces
Vokoun, David; He, Q.; Heller, Luděk; Yu, M.; Dai, Z.
2015-01-01
Roč. 12, č. 1 (2015), s. 142-151. ISSN 1672-6529 R&D Projects: GA ČR GB14-36566G Institutional support: RVO:68378271 Keywords : ionic polymer metal composite * actuator * blocking force * finite element method Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.632, year: 2014
Modelling of composite concrete block pavement systems applying a cohesive zone model
Skar, Asmus; Poulsen, Peter Noe
This paper presents a numerical analysis of the fracture behaviour of the cement bound base material in composite concrete block pavement systems, using a cohesive zone model. The functionality of the proposed model is tested on experimental and numerical investigations of beam bending tests. The...... cohesive model is suitable for simulation of crack propagation in cement bound materials subjected to monotonic loading. The methodology implemented gives a new understanding of the mechanical behaviour of cement bound materials which can be used in further refinements of mechanical models for composite...
Martin Boeff; Anxin Ma; Alexander Hartmaier
2014-01-01
The plastic deformations of tempered martensite steel representative volume elements with different martensite block structures have been investigated by using a nonlocal crystal plasticity model which considers isotropic and kinematic hardening produced by plastic strain gradients. It was found that pronounced strain gradients occur in the grain boundary region even under homogeneous loading. The isotropic hardening of strain gradients strongly influences the global stress–strain diagram whi...
Non-linear dynamic analysis of ancient masonry structures by 3D rigid block models
Orduña, Agustin; Ayala, A. Gustavo
2015-12-01
This work presents a formulation for non-linear dynamic analysis of unreinforced masonry structures using rigid block models. This procedure is akin to the distinct element family of methods, nevertheless, we assume that small displacements occur and, therefore, the formulation does not involve the search for new contacts between blocks. This proposal is also related to the rigid element method, although, in this case we use full three-dimensional models and a more robust interface formulation.
Diagnostic analysis and spectral energetics of a blocking event in the GLAS climate model simulation
Chen, T.-C.; Shukla, J.
1983-01-01
A synoptic and spectral analysis of a blocking event is presented, with attention given to the temporal evolution, maintenance, and decay of the block. The GLAS numerical climate model was used to generate a blocking event by the introduction of SST anomalies. Wavenumbers 2 and 3 became stationary around their climatological locations, and their constructive interference produced persistent blocking ridges over the west coast of North America and the other over western Europe. Time variations of the kinetic and potential energies and energy conversions during the blocking were performed. Spectrally filtered Hovmoller diagrams were developed for the winter of 1976-77, and showed that long waves were stationary over most of the interval, which featured severe weather conditions.
Wang, Haibo; Swee Poo, Gee
2004-08-01
We study the provisioning of virtual private network (VPN) service over WDM optical networks. For this purpose, we investigate the blocking performance of the hose model versus the pipe model for the provisioning. Two techniques are presented: an analytical queuing model and a discrete event simulation. The queuing model is developed from the multirate reduced-load approximation technique. The simulation is done with the OPNET simulator. Several experimental situations were used. The blocking probabilities calculated from the two approaches show a close match, indicating that the multirate reduced-load approximation technique is capable of predicting the blocking performance for the pipe model and the hose model in WDM networks. A comparison of the blocking behavior of the two models shows that the hose model has superior blocking performance as compared with pipe model. By and large, the blocking probability of the hose model is better than that of the pipe model by a few orders of magnitude, particularly at low load regions. The flexibility of the hose model allowing for the sharing of resources on a link among all connections accounts for its superior performance.
Franjo Šumanovac
2007-12-01
Full Text Available The block model in a homogenous environment can generally serve for presentation of some geological models: changes of facies, changes of rock compactness-fragmentation, underground cavities, bauxite deposits, etc. Therefore, on the block model of increased resistivities in a homogenous environment of low resistivity, the potentials of the electrical tomography method were tested for the purpose of their detection. Regarding potentials of block detection, resolution methods depend on: depth of block location, ratio between block resistivity and the environment in which it is located as well as applied survey geometry, i.e. electrode array. Thus the analyses carried out for the most frequently used electrode arrays in the investigations are the following: the Wenner, Wenner-Schlumberger, dipole-dipole and pole-pole arrays. For each array, maximum depths at which a block can be detected relative to the ratio between block resistivity and parent rock environment were analyzed. The results are shown in the two-dimensional graphs, where the ratio between the block resistivity and the environment is shown on the X-axis, and the resolution depth on the Y-axis, after which the curves defining the resolution limits were drawn. These graphs have a practical use, since they enable a fast, simple determination of potentials of the method application on a specific geological model.
Abdenaceur Boudlal
2010-01-01
Full Text Available This article investigates a new method of motion estimation based on block matching criterion through the modeling of image blocks by a mixture of two and three Gaussian distributions. Mixture parameters (weights, means vectors, and covariance matrices are estimated by the Expectation Maximization algorithm (EM which maximizes the log-likelihood criterion. The similarity between a block in the current image and the more resembling one in a search window on the reference image is measured by the minimization of Extended Mahalanobis distance between the clusters of mixture. Performed experiments on sequences of real images have given good results, and PSNR reached 3 dB.
Dynamic interaction of slip displacement accumulation in a two-block Newmark model
Zania, Varvara; Tsompanakis, Y.; Psarropoulos, Prodromos N.
2011-01-01
aforementioned interfaces. The well-known Newmark’s sliding block has been widely applied to mimic the seismic response of structures with distinct interfaces. In the current study a new model is presented, which is based on the principles of Newmark’s approach. This model comprises of three stacked rigid blocks...... reduction of the permanent relative displacements along both interfaces. The interaction mechanism is dominated by the inclination of the sliding planes, the mass ratio of the two blocks, the ratio of the yield acceleration of the two interfaces and the angle of friction of the lower interface. Moreover......, the sensitivity of the interaction mechanism to the excitation characteristics and to the mass of the two blocks was also investigated...
Physical and theoretical modeling of rock slopes against block-flexure toppling failure
Mehdi Amini
2015-12-01
Full Text Available Block-flexure is the most common mode of toppling failure in natural and excavated rock slopes. In such failure, some rock blocks break due to tensile stresses and some overturn under their own weights and then all of them topple together. In this paper, first, a brief review of previous studies on toppling failures is presented. Then, the physical and mechanical properties of experimental modeling materials are summarized. Next, the physical modeling results of rock slopes with the potential of block-flexural toppling failures are explained and a new analytical solution is proposed for the stability analysis of such slopes. The results of this method are compared with the outcomes of the experiments. The comparative studies show that the proposed analytical approach is appropriate for the stability analysis of rock slopes against block-flexure toppling failure. Finally, a real case study is used for the practical verification of the suggested method.
Markovian Building Blocks for Individual-Based Modelling
Nilsson, Lars Anders Fredrik
2007-01-01
The present thesis consists of a summary report, four research articles, one technical report and one manuscript. The subject of the thesis is individual-based stochastic models. The summary report is composed of three parts and a brief history of some basic models in population biology. This his......The present thesis consists of a summary report, four research articles, one technical report and one manuscript. The subject of the thesis is individual-based stochastic models. The summary report is composed of three parts and a brief history of some basic models in population biology....... This history is included in order to provide a reader that has no previous exposure to models in population biology with a sufficient background to understand some of the biological models that are mentioned in the thesis. The first part of the rest of the summary is a description of the dramatic changes...... in the degree of aggregation of sprat or herring in the Baltic during the day, with special focus on the dispersion of the fish from schools at dusk. The next part is a brief introduction to Markovian arrival processes, a type of stochastic processes with potential applications as sub-models in population...
Traffic Modelling for Moving-Block Train Control System
TANG Tao; LI Ke-Ping
2007-01-01
This paper presents a new cellular automaton (CA) model for train control system simulation.In the proposed CA model,the driver reactions to train movements are captured by some updated rules.The space-time diagram of traffic flow and the trajectory of train movement is used to obtain insight into the characteristic behavior of railway traffic flow.A number of simulation results demonstrate that the proposed CA model can be successfully used for the simulations of railway traffic.Not only the characteristic behavior of railway traffic flow can be reproduced,but also the simulation values of the minimum time headway are close to the theoretical values.
Traffic Modelling for Moving-Block Train Control System
This paper presents a new cellular automaton (CA) model for train control system simulation. In the proposed CA model, the driver reactions to train movements are captured by some updated rules. The space-time diagram of traffic flow and the trajectory of train movement is used to obtain insight into the characteristic behavior of railway traffic flow. A number of simulation results demonstrate that the proposed CA model can be successfully used for the simulations of railway traffic. Not only the characteristic behavior of railway traffic flow can be reproduced, but also the simulation values of the minimum time headway are close to the theoretical values.
Modeling Data Center Building Blocks for Energy-efficiency and Thermal Simulations
Vor Dem Berge, Micha; Da Costa, Georges; Jarus, Mateusz; Oleksiak, Ariel; Piatek, Wojciech; Volk, Eugen
2013-01-01
In this paper we present a concept and specification of Data Center Efficiency Building Blocks (DEBBs), which represent hardware components of a data center complemented by descriptions of their energy efficiency. Proposed building blocks contain hardware and thermodynamic models that can be applied to simulate a data center and to evaluate its energy efficiency. DEBBs are available in an open repository being built by the CoolEmAll project. In the paper we illustrate the concept by an exampl...
A novel code generation methodology for block diagram modeler and simulators Scicos and VSS
Chancelier, Jean-Philippe; Nikoukhah, Ramine
2015-01-01
Block operations during simulation in Scicos and VSS environments can naturally be described as Nsp functions. But the direct use of Nsp functions for simulation leads to poor performance since the Nsp language is interpreted, not compiled. The methodology presented in this paper is used to develop a tool for generating efficient compilable code, such as C and ADA, for Scicos and VSS models from these block Nsp functions. Operator overloading and partial evaluation are the key elements of thi...
The Financial Block in the Econometric Model KOSMOS
Markowski, Aleksander
1996-01-01
The model includes seven sectors (Central Bank, central government, banks mortgage institutions, private and social insurance, non-financial business and households, foreign) and nine asset categories (certificates, bonds, bank deposits, loans, equity, net foreign assets, notes and coin, insurance savings and claims on the National Savings Scheme). Emphasis was laid on modelling demand for bonds and certificates, which in turn affects the bond rate and the money stock. Sector demand for equit...
A SIGNALING MODEL OF CONTROL BLOCK SALES BY ENTREPRENEURS
Lynda S. Livingston
2007-01-01
In this paper, we present a model in which higher-valued managers signal their value by voluntarily submitting to shareholder oversight. If a manager is willing to sell enough stock to release voting control, he is perceived to be of higher quality than if he had defensively maintained control. The implication of the model is that voluntary/control sales by insiders can be good news for the firm. This is consistent with the share-price increases that follow the deaths of entrenched managers.
Twenty years on: Atmospheric blocking representation in Global Climate Models from AMIP to CMIP-5
Davini, Paolo; D'Andrea, Fabio
2016-04-01
Atmospheric blocking simulation has always been a big concern for Global Climate Models (GCMs). Making use of a series of equivalent metrics, the improvement of GCMs since the 90s to nowadays is assessed. Results from the AMIP (1992), the CMIP-3 (2007) and the CMIP-5 (2012) inter-comparison projects are analyzed, using both coupled and atmospheric-only models for a total of 82 climate models. Although large improvements are seen over the Pacific ocean minor success has been achieved over the Euro-Atlantic sector, where many state-of-the-art GCMs still exhibits the same negative bias as 20 years ago - associated with large geopotential height systematic errors. Even though, some of the CMIP-5 models reasonably represent the climatological frequency of blocking over both basins. Negligible differences emerge among coupled or atmospheric-only simulations, suggesting weak relevance of sea surface temperatures biases. Conversely, increased horizontal resolution seems cardinal to resolve European Blocking.
Sousa, A.M.; Ashmawi, H.A.; Costa, L.S.; Posso, I.P. [LIM-08 - Anestesiologia Experimental, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP (Brazil); Slullitel, A. [Departamento de Anestesiologia, Hospital Santa Paula, São Paulo, SP (Brazil)
2011-12-23
Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2% lidocaine or tramadol (1.25 and 5 mg) was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the flinching behavior test. In the plantar incision model, tramadol (1.25 mg) increased both paw withdrawal latency in response to radiant heat (8.3 ± 1.1, 12.7 ± 1.8, 8.4 ± 0.8, and 11.1 ± 3.3 s) and mechanical threshold in response to von Frey filaments (459 ± 82.8, 447.5 ± 91.7, 320.1 ± 120, 126.43 ± 92.8 mN) at 5, 15, 30, and 60 min, respectively. Sham block or contralateral sciatic nerve block did not differ from perineural saline injection throughout the study in either model. The effect of tramadol was not antagonized by intraperitoneal naloxone. High dose tramadol (5 mg) blocked motor function as well as 2% lidocaine. In conclusion, tramadol blocks nociception and motor function in vivo similar to local anesthetics.
A.M. Sousa
2012-02-01
Full Text Available Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2% lidocaine or tramadol (1.25 and 5 mg was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the flinching behavior test. In the plantar incision model, tramadol (1.25 mg increased both paw withdrawal latency in response to radiant heat (8.3 ± 1.1, 12.7 ± 1.8, 8.4 ± 0.8, and 11.1 ± 3.3 s and mechanical threshold in response to von Frey filaments (459 ± 82.8, 447.5 ± 91.7, 320.1 ± 120, 126.43 ± 92.8 mN at 5, 15, 30, and 60 min, respectively. Sham block or contralateral sciatic nerve block did not differ from perineural saline injection throughout the study in either model. The effect of tramadol was not antagonized by intraperitoneal naloxone. High dose tramadol (5 mg blocked motor function as well as 2% lidocaine. In conclusion, tramadol blocks nociception and motor function in vivo similar to local anesthetics.
Local anesthetic efficacy of tramadol has been reported following intradermal application. Our aim was to investigate the effect of perineural tramadol as the sole analgesic in two pain models. Male Wistar rats (280-380 g; N = 5/group) were used in these experiments. A neurostimulation-guided sciatic nerve block was performed and 2% lidocaine or tramadol (1.25 and 5 mg) was perineurally injected in two different animal pain models. In the flinching behavior test, the number of flinches was evaluated and in the plantar incision model, mechanical and heat thresholds were measured. Motor effects of lidocaine and tramadol were quantified and a motor block score elaborated. Tramadol, 1.25 mg, completely blocked the first and reduced the second phase of the flinching behavior test. In the plantar incision model, tramadol (1.25 mg) increased both paw withdrawal latency in response to radiant heat (8.3 ± 1.1, 12.7 ± 1.8, 8.4 ± 0.8, and 11.1 ± 3.3 s) and mechanical threshold in response to von Frey filaments (459 ± 82.8, 447.5 ± 91.7, 320.1 ± 120, 126.43 ± 92.8 mN) at 5, 15, 30, and 60 min, respectively. Sham block or contralateral sciatic nerve block did not differ from perineural saline injection throughout the study in either model. The effect of tramadol was not antagonized by intraperitoneal naloxone. High dose tramadol (5 mg) blocked motor function as well as 2% lidocaine. In conclusion, tramadol blocks nociception and motor function in vivo similar to local anesthetics
Application of Seismic Data to Reservoir Modeling of the Chegu 201 Block
CaiYi; ZhangXiangzhong; ZhangXinshang
2005-01-01
Great uncertainty exists in reservoir models built for blocks where well spacing is uneven or large. The uncertainty in reservoir models can be significantly reduced by using Coordinate Cokriging Sequential Gaussian Simulation technology, in combination with the restriction of seismic characteristic data. Satisfactory reservoir parameter interpolation results, which are more accurate than those derived only from borehole data, are obtained, giving rise to a reasonable combination of widespread and dense-sampled seismic (soft data) data with borehole data (hard data). A significant effect has been made in reservoir parameter modeling in the Chegu 201 block of the Futai Oilfield by using this technology.
Bayesian Degree-Corrected Stochastic Block Models for Community Detection
Peng, Lijun
2013-01-01
Community detection in networks has drawn much attention in diverse fields, especially social sciences. Given its significance, there has been a large body of literature among which many are not statistically based. In this paper, we propose a novel stochastic blockmodel based on a logistic regression setup with node correction terms to better address this problem. We follow a Bayesian approach that explicitly captures the community behavior via prior specification. We then adopt a data augmentation strategy with latent Polya-Gamma variables to obtain posterior samples. We conduct inference based on a canonically mapped centroid estimator that formally addresses label non-identifiability. We demonstrate the novel proposed model and estimation on real-world as well as simulated benchmark networks and show that the proposed model and estimator are more flexible, representative, and yield smaller error rates when compared to the MAP estimator from classical degree-corrected stochastic blockmodels.
Barriopedro, D. [Universidade de Lisboa, CGUL-IDL, Faculdade de Ciencias, Ed. C-8, Lisbon (Portugal); Universidad de Extremadura, Departamento de Fisica, Facultad de Ciencias, Badajoz (Spain); Garcia-Herrera, R. [Universidad Complutense de Madrid, Departamento de Fisica de la Tierra II, Facultad de C.C. Fisicas, Madrid (Spain); Trigo, R.M. [Universidade de Lisboa, CGUL-IDL, Faculdade de Ciencias, Ed. C-8, Lisbon (Portugal)
2010-12-15
This paper aims to provide a new blocking definition with applicability to observations and model simulations. An updated review of previous blocking detection indices is provided and some of their implications and caveats discussed. A novel blocking index is proposed by reconciling two traditional approaches based on anomaly and absolute flows. Blocks are considered from a complementary perspective as a signature in the anomalous height field capable of reversing the meridional jet-based height gradient in the total flow. The method succeeds in identifying 2-D persistent anomalies associated to a weather regime in the total flow with blockage of the westerlies. The new index accounts for the duration, intensity, extension, propagation, and spatial structure of a blocking event. In spite of its increased complexity, the detection efficiency of the method is improved without hampering the computational time. Furthermore, some misleading identification problems and artificial assumptions resulting from previous single blocking indices are avoided with the new approach. The characteristics of blocking for 40 years of reanalysis (1950-1989) over the Northern Hemisphere are described from the perspective of the new definition and compared to those resulting from two standard blocking indices and different critical thresholds. As compared to single approaches, the novel index shows a better agreement with reported proxies of blocking activity, namely climatological regions of simultaneous wave amplification and maximum band-pass filtered height standard deviation. An additional asset of the method is its adaptability to different data sets. As critical thresholds are specific of the data set employed, the method is useful for observations and model simulations of different resolutions, temporal lengths and time variant basic states, optimizing its value as a tool for model validation. Special attention has been paid on the devise of an objective scheme easily applicable
Evolutionary Modelling in Economics : A Survey of Methods and Building Blocks
Safarzynska, Karolina; Jeroen C.J.M. van den Bergh
2008-01-01
In this paper we present an overview of methods and components of formal economic models employing evolutionary approaches. This compromises two levels: (1) techniques of evolutionary modelling, including multi-agent modelling, evolutionary algorithms and evolutionary game theory; (2) building blocks or components of formal models classified into core processes and features of evolutionary systems - diversity, innovation and selection - and additional elements, such as bounded rationality, di...
Valuation model of exploratory blocks; Modelo de valoracao de blocos exploratorios
Campos, Thiago Neves de; Sartori, Vanderlei [Agencia Nacional do Petroleo, Gas Natural e Biocombustiveis (ANP), Rio de Janeiro, RJ (Brazil)
2008-07-01
Last year completed 10 years of the promulgations of the Brazilian Petroleum Act. This act has regulated the of the sector of exploration and production of oil and natural gas in Brazil, enabling these activities were granted to private or state companies, preceded by a bidding round. Since 1998, ANP have been doing these bids, using in the judgment of offers the following criteria: Minimum Exploration Program, Local Content and Bonuses of Signature. The objective of this article is to present a model of valuation of the blocks on offer, showing a model of estimation of the monetary value of the block. (author)
Mechanical Strength Modeling and Optimization of Lateritic Solid Block with 4% Mound Soil Inclusion
Onuamah, P. N.; Ezeokpube G.C.
2015-01-01
The work is an investigation for the model development and optimization of the compressive strength of solid sandcrete block with mound soil inclusion. The study applies the Scheffe’s optimization approach to obtain a mathematical model of the form f(xi1,xi2,xi3,,xi4), where xi are proportions of the concrete components, viz: cement, mound soil, laterite, and water. Scheffe’s experimental design techniques are followed to mould various solid block samples measuring 450mm x 225mm x 150mm...
Wilson, James D; Woodall, William H
2016-01-01
In many applications it is of interest to identify anomalous behavior within a dynamic interacting system. Such anomalous interactions are reflected by structural changes in the network representation of the system. We propose and investigate the use of a dynamic version of the degree corrected stochastic block model (DCSBM) as a means to model and monitor dynamic networks that undergo a significant structural change. Our model provides a means to simulate a variety of local and global changes in a time-varying network. Furthermore, one can efficiently detect such changes using the maximum likelihood estimates of the parameters that characterize the DCSBM. We assess the utility of the dynamic DCSBM on both simulated and real networks. Using a simple monitoring strategy on the DCSBM, we are able to detect significant changes in the U.S. Senate co-voting network that reflects both times of cohesion and times of polarization among Republican and Democratic members. Our analysis suggests that the dynamic DCSBM pr...
The Three-Block Model of Universal Design for Learning Implementation in a High School
Katz, Jennifer; Sugden, Ron
2013-01-01
The role of the school leader (principal) in supporting educational reform is explored through a case study of one high school implementing the Three Block Model of UDL (Katz, 2012a) in an effort to meet the needs of a diverse student population. This case study is a part of a much larger study exploring outcomes for students and teachers of…
Katz, Jennifer
2013-01-01
When the Three Block Model of Universal Design for Learning (Katz, 2012a) is implemented, outcomes related to student academic and social engagement were investigated in this study. 631 students from Grades 1 to 12 attending ten schools located in two rural and three urban school divisions in Manitoba took part in the study. Intervention and…
A GLE multi-block model for the evaluation of seismic displacements of slopes
The paper describes a multi-block displacement model for the evaluation of seismic permanent displacements of natural slopes with slip surface of general shape. A rigorous limit equilibrium method of stability analysis is considered and an application to an ideal clay slope is presented including the effect of excess pore pressure build-up on the displacement response
Baranovskaya T. P.
2014-06-01
Full Text Available The article describes the fuzzy-multiple approach and the block of fuzzy (interval mathematical models developed by the authors for calculating the amounts of material and financial flows, prices for bread and economic efficiency in a technologically integrated bread production system
Shape Optimization of Hollow Concrete Blocks Using the Lattice Discrete Particle Model
Fatemeh Javidan
2013-01-01
Full Text Available Hollow concrete blocks are one of the widely used building elements of masonry structures in whichthey are normally loaded under combined action of shear and compression. Accordingly and due to theirstructural importance, the present study intends to numerically search for an optimum shape of such blocks.The optimality index is selected to be the ratio of block’s failure strength to its weight, a non-dimensionalparameter, which needs to be maximized. The nonlinear analysis has been done using a homemade code writtenbased on the recently developed Lattice Discrete Particle Model (LDPM for the meso-scale simulation ofconcrete. This numerical approach accounts for the different aspects of concrete’s complex behavior such astensile fracturing, cohesive and frictional shearing and also its nonlinear compressive response. The modelparameters were calibrated against previously reported experimental data. Various two-core configurations forthe hollow blocks are examined, compared and discussed.
Mechanical Strength Modeling and Optimization of Lateritic Solid Block with 4% Mound Soil Inclusion
Onuamah, P.N
2015-05-01
Full Text Available The work is an investigation for the model development and optimization of the compressive strength of solid sandcrete block with mound soil inclusion. The study applies the Scheffe’s optimization approach to obtain a mathematical model of the form f(xi1,xi2,xi3,,xi4, where xi are proportions of the concrete components, viz: cement, mound soil, laterite, and water. Scheffe’s experimental design techniques are followed to mould various solid block samples measuring 450mm x 225mm x 150mm and tested for 28 days strength. The task involved experimentation and design, applying the second order polynomial characterization process of the simplex lattice method. The model adequacy is checked using the control factors. Finally a software is prepared to handle the design computation process to take the desired property of the mix, and generate the optimal mix ratios.
A new approach to modelling and designing mono-block dental implants
R. Hunter
2007-05-01
Full Text Available Purpose: of this paper is present a new approach to modelling and design the low cost mono-block dental implants based on the integration of the computer aided techniques. This approach provides the automation of the design process of the mono-block dental implants.Design/methodology/approach: The approach used to develop the modelling and design of the mono-block dental implants are based on the parametrization of the main geometric features of the implants. This approach allows to generate several designs of the implant with different configurations respect to the dimensions, forms and tolerances.Findings: The findings are focused on two main topics. The first one is the minimization of the manufacturing cost and time based on the manufacture process automation. The second one is the integration, in the same informatics platform, of the design, analysis and manufacturing environment.Research limitations/implications: The implications are focused on the development of a new design of mono-block dental implants. One of the main features of this design is associated to the reduction of the surgical stage and their simplification respect to other commercial implants.Practical implications: The main outcomes and implications of this research is the design of a low cost dental implant. This solution is implemented to assist the social programs of oral health.Originality/value: The originality of this research is the design of a new model of mono-block dental implant. The structure of this implant improves the mechanical properties; reduce the manufacturing cost and the surgical complications.
Zhao, Wentao; Hou, Guiting; Hari, K. R.
2016-07-01
The importance of the Ordos Block, which is surrounded by different Chinese continental blocks, is well documented, but the development of the structural fractures and the stress fields within the Late Mesozoic and Cenozoic eras in this stable block (dips of the Mesozoic and Cenozoic strata are less than 3°) have been poorly studied. In this paper, two dominant groups of structural fractures with NW to EW and NNE to ENE trends are identified through field measurements and imaging log observations. The maximum principal compressive stress magnitudes and stress trajectories are calculated employing 2D finite element models (2D-FEM). Based on the displacement fields, the rotation of the Ordos Block and comparisons between the measured and the calculated stresses, it can be deduced that there are two episodes of fracture formation in the Ordos Block. The calculated orientations of maximum compressive stress in the Late Mesozoic and the Cenozoic eras are found to be WNW and NE respectively, which imply that the NW to EW trending structural fractures were developed in a Late Mesozoic stress field whereas the NNE to ENE ones were developed in a Cenozoic stress field in the block. The change in stress fields may have resulted in the change in tectonic setting from the northwestward subduction of the Izanagi Plate in the Late Mesozoic to the collision between the Indian Plate and the Eurasian Plate in the Cenozoic. The change in the Mesozoic and Cenozoic stress fields is of great significance to the further fracture prediction in fractured reservoirs, basin analyses in the Ordos Basin and research on the geodynamics of the North China Craton.
Modeling Block Failure in Vertical Cliffs of Arctic Coasts Underlain by Permafrost
Pollard, W. H.
2004-12-01
Arctic coasts lie at the interface between terrestrial systems dominated by permafrost, and marine systems that are characterized by long periods of ice cover and short periods of open water when wave action and storm activity are important. Permafrost, sea ice and wind-wave conditions are driven by regional and local climate forcing and interact in such a way that a change in one produces feedbacks affecting the other two. However, under predicted climate change scenarios of warming, increased storm activity and sea level rise will profoundly affect all three leading to potentially devastating rates of coastal erosion and permafrost degradation. Permafrost coasts are subject to complex erosional processes, however one of the most poorly understood but probably most important is block failure. Thermo-abrasional falls or block collapses provide the most spectacular form of coastal recession in permafrost areas. This study provides computational models for block failure mechanisms and investigates the relative contribution of horizontal thermo-erosional niches and ice wedges to block failure of permafrost cliffs fronted by a beach.
Arctic warming, atmospheric blocking and cold European winters in CMIP5 models
Amplified Arctic warming is expected to have a significant long-term influence on the midlatitude atmospheric circulation by the latter half of the 21st century. Potential influences of recent and near future Arctic changes on shorter timescales are much less clear, despite having received much recent attention in the literature. In this letter, climate models from the recent CMIP5 experiment are analysed for evidence of an influence of Arctic temperatures on midlatitude blocking and cold European winters in particular. The focus is on the variability of these features in detrended data and, in contrast to other studies, limited evidence of an influence is found. The occurrence of cold European winters is found to be largely independent of the temperature variability in the key Barents–Kara Sea region. Positive correlations of the Barents–Kara temperatures with Eurasian blocking are found in some models, but significant correlations are limited. (paper)
Optimal generators for a systematic block code model of prokaryotic translation initiation
The decoding of received error control encoded bit streams is fairly straightforward when the channel encoding algorithms are efficient and known. But if the encoding scheme is unknown or part of the data is missing, how would one design a viable decoder for the received transmission? Communication engineers may not frequently encounter this situation, but for computational biologists this is an immediate challenge as we attempt to decipher and understand the vast amount of sequence data produced by genome sequencing projects. Assuming the systematic parity check block code model of protein translation initiation, this work presents an approach for determining the generator matrix given a set of potential codewords. The resulting generators and corresponding parity matrices are applied to valid and invalid Escherichia coli K-12 MG1655 messenger RNA leader sequences. The generators constructed using strict subsets of the 16S ribosomal RNA performed better than those constructed using the block code model in earlier works.
AN EFFECTIVE MODEL TO EVALUATE BLOCKING PROBABILITY OF TIME-SLOTTED OPTICAL BURST SWITCHED NETWORKS
Yang Zongkai; Ou Liang; Tan Xiansi
2006-01-01
Time-slotted optical burst switched network is a potential technique to support IP over Wavelength Division Multiplexing (WDM) by introduce Time Division Multiplexing (TDM) channel to Optical Burst Switching (OBS) technology. This paper presents a framework to evaluate blocking performance of time-slotted OBS networks with multi-fiber wavelength channels. The proposed model is efficient for not only single class traffic such as individual circuit switch traffics or best-effort traffics but also mixed multi-class traffics.The effectiveness of the proposed model is validated by simulation results. The study shows that blocking performance of multi-fiber TS-OBS network is acceptable for future Internet services.
Discrete matrix models for partial sums of conformal blocks associated to Painlevé transcendents
Balogh, F.
2015-01-01
A recently formulated conjecture of Gamayun, Iorgov and Lisovyy gives an asymptotic expansion of the Jimbo-Miwa-Ueno isomonodromic τ-function for certain Painlevé transcendents. The coefficients in this expansion are given in terms of conformal blocks of a two-dimensional conformal field theory, which can be written as infinite sums over pairs of partitions. In this note a discrete matrix model is proposed on a lattice whose partition function can be used to obtain a multiple integral representation for the length-restricted partial sums of the Painlevé conformal blocks. This leads to expressions of the partial sums involving Hänkel determinants associated to the discrete measure of the matrix model, or equivalently, Wronskians of the corresponding moment generating function which is shown to be of the generalized hypergeometric type.
Discrete matrix models for partial sums of conformal blocks associated to Painlev\\'e transcendents
Balogh, F
2014-01-01
A recently formulated conjecture of Gamayun, Iorgov and Lisovyy gives an asymptotic expansion of the Jimbo--Miwa--Ueno isomonodromic $\\tau$-function for certain Painlev\\'e transcendents. The coefficients in this expansion are given in terms of conformal blocks of a two-dimensional conformal field theory, which can be written as infinite sums over pairs of partitions. In this note a discrete matrix model is proposed on a lattice whose partition function can be used to obtain a multiple integral representation for the length restricted partial sums of the Painlev\\'e conformal blocks. This leads to expressions of the partial sums involving H\\"ankel determinants associated to the discrete measure of the matrix model, or equivalently, Wronskians of the corresponding moment generating function which is shown to be of the generalized hypergeometric type.
Chu, Chunlei
2009-01-01
The major performance bottleneck of the parallel Fourier method on distributed memory systems is the network communication cost. In this study, we investigate the potential of using non‐blocking all‐to‐all communications to solve this problem by overlapping computation and communication. We present the runtime comparison of a 3D seismic modeling problem with the Fourier method using non‐blocking and blocking calls, respectively, on a Linux cluster. The data demonstrate that a performance improvement of up to 40% can be achieved by simply changing blocking all‐to‐all communication calls to non‐blocking ones to introduce the overlapping capability. A 3D reverse‐time migration result is also presented as an extension to the modeling work based on non‐blocking collective communications.
Comparison of vibration test results for Atucha II NPP and large scale concrete block models
In order to study the soil structure interaction of reactor building that could be constructed on a Quaternary soil, a comparison study of the soil structure interaction springs was performed between full scale vibration test results of Atucha II NPP and vibration test results of large scale concrete block models constructed on Quaternary soil. This comparison study provides a case data of soil structure interaction springs on Quaternary soil with different foundation size and stiffness. (author)
Modeling of a Hot Gas Bypass Test Block for Centrifugal Compressors
Gessler, Paul D.; Mathison, Margaret M.; Bowman, Anthony J.
2014-01-01
The increasingly competitive building equipment and control industry pushes manufacturers to devote more resources each year to research and development, continually improving the performance and efficiency of their products to develop and maintain a competitive edge. Compressor development is an expensive endeavor because of prototyping and testing costs, but the cost and time required for testing can be minimized by developing a model of the compressor test block to predict its behavior wit...
Discrete matrix models for partial sums of conformal blocks associated to Painlev\\'e transcendents
Balogh, F.
2014-01-01
A recently formulated conjecture of Gamayun, Iorgov and Lisovyy gives an asymptotic expansion of the Jimbo--Miwa--Ueno isomonodromic $\\tau$-function for certain Painlev\\'e transcendents. The coefficients in this expansion are given in terms of conformal blocks of a two-dimensional conformal field theory, which can be written as infinite sums over pairs of partitions. In this note a discrete matrix model is proposed on a lattice whose partition function can be used to obtain a multiple integra...
A Scalable Blocked Gibbs Sampling Algorithm For Gaussian And Poisson Regression Models
Johnson, Nicholas A.; Kuehnel, Frank O.; Amini, Ali Nasiri
2016-01-01
Markov Chain Monte Carlo (MCMC) methods are a popular technique in Bayesian statistical modeling. They have long been used to obtain samples from posterior distributions, but recent research has focused on the scalability of these techniques for large problems. We do not develop new sampling methods but instead describe a blocked Gibbs sampler which is sufficiently scalable to accomodate many interesting problems. The sampler we describe applies to a restricted subset of the Generalized Linea...
Li Kaile; Ma Lijun [Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD 21210 (United States)
2004-08-07
We have developed an automatic critical region shielding (ACRS) algorithm for Gamma Knife radiosurgery of trigeminal neuralgia. The algorithm selectively blocks 201 Gamma Knife sources to minimize the dose to the brainstem while irradiating the root entry area of the trigeminal nerve with 70-90 Gy. An independent dose model was developed to implement the algorithm. The accuracy of the dose model was tested and validated via comparison with the Leksell GammaPlan (LGP) calculations. Agreements of 3% or 3 mm in isodose distributions were found for both single-shot and multiple-shot treatment plans. After the optimized blocking patterns are obtained via the independent dose model, they are imported into the LGP for final dose calculations and treatment planning analyses. We found that the use of a moderate number of source plugs (30-50 plugs) significantly lowered ({approx}40%) the dose to the brainstem for trigeminal neuralgia treatments. Considering the small effort involved in using these plugs, we recommend source blocking for all trigeminal neuralgia treatments with Gamma Knife radiosurgery.
We have developed an automatic critical region shielding (ACRS) algorithm for Gamma Knife radiosurgery of trigeminal neuralgia. The algorithm selectively blocks 201 Gamma Knife sources to minimize the dose to the brainstem while irradiating the root entry area of the trigeminal nerve with 70-90 Gy. An independent dose model was developed to implement the algorithm. The accuracy of the dose model was tested and validated via comparison with the Leksell GammaPlan (LGP) calculations. Agreements of 3% or 3 mm in isodose distributions were found for both single-shot and multiple-shot treatment plans. After the optimized blocking patterns are obtained via the independent dose model, they are imported into the LGP for final dose calculations and treatment planning analyses. We found that the use of a moderate number of source plugs (30-50 plugs) significantly lowered (∼40%) the dose to the brainstem for trigeminal neuralgia treatments. Considering the small effort involved in using these plugs, we recommend source blocking for all trigeminal neuralgia treatments with Gamma Knife radiosurgery
Li, Kaile; Ma, Lijun
2004-08-01
We have developed an automatic critical region shielding (ACRS) algorithm for Gamma Knife radiosurgery of trigeminal neuralgia. The algorithm selectively blocks 201 Gamma Knife sources to minimize the dose to the brainstem while irradiating the root entry area of the trigeminal nerve with 70-90 Gy. An independent dose model was developed to implement the algorithm. The accuracy of the dose model was tested and validated via comparison with the Leksell GammaPlan (LGP) calculations. Agreements of 3% or 3 mm in isodose distributions were found for both single-shot and multiple-shot treatment plans. After the optimized blocking patterns are obtained via the independent dose model, they are imported into the LGP for final dose calculations and treatment planning analyses. We found that the use of a moderate number of source plugs (30-50 plugs) significantly lowered (~40%) the dose to the brainstem for trigeminal neuralgia treatments. Considering the small effort involved in using these plugs, we recommend source blocking for all trigeminal neuralgia treatments with Gamma Knife radiosurgery.
Yasuhiro Omori; Toshiaki Watanabe
2007-01-01
This article introduces a new efficient simulation smoother and disturbance smoother for general state-space models where there exists a correlation between error terms of the measurement and state equations. The state vector is divided into several blocks where each block consists of many state variables. For each block, corresponding disturbances are sampled simultaneously from their conditional posterior distribution. The algorithm is based on the multivariate normal approximation of the c...
Final report of the TRUE Block Scale project. 1. Characterisation and model development
The general objectives of the TRUE Block Scale Project were to 1) increase understanding of tracer transport in a fracture network and to improve predictive capabilities, 2) assess the importance of tracer retention mechanisms (diffusion and sorption) in a fracture network, and 3) assess the link between flow and transport data as a means for predicting transport phenomena. During the period mid 1996 through mid 1999 a 200x250x100 m rock volume was characterised with the purpose of furnishing the basis for successful tracer experiments in a network of conductive structures in the block scale (10-100 m). In total five cored boreholes were drilled as part of the project in an iterative mode with a period of analysis following completion of characterisation, and with a strong component of inter activity with numerical modelling and experimental design, particularly towards the end of the characterisation. The combined use of pressure responses due to drilling and drilling records provided important early information/confirmation of the existence and location of a given structure. Verification of conductors identified from pressure responses was achieved through the use of various flow logging techniques. The usage of the Posiva difference flow log towards the end of the characterisation work enabled identification of discrete conductive fractures with a high resolution. Pressure responses collected during drilling were used to obtain a first assessment of connectivity between boreholes. The transient behaviour of the responses collected during cross-hole interference tests in packed-off boreholes were used to identify families of responses, which correlated well with the identified principal families of structures/fracture networks. The conductive geometry of the investigated rock block is made up of steeply dipping deterministic NW structures and NNW structures. High inflows in the boreholes were for the most part associated with geologically/geometrically identified
Block modeling of crustal deformation in Tierra del Fuego from GNSS velocities
Mendoza, L.; Richter, A.; Fritsche, M.; Hormaechea, J. L.; Perdomo, R.; Dietrich, R.
2015-05-01
The Tierra del Fuego (TDF) main island is divided by a major transform boundary between the South America and Scotia tectonic plates. Using a block model, we infer slip rates, locking depths and inclinations of active faults in TDF from inversion of site velocities derived from Global Navigation Satellite System observations. We use interseismic velocities from 48 sites, obtained from field measurements spanning 20 years. Euler vectors consistent with a simple seismic cycle are estimated for each block. In addition, we introduce far-field information into the modeling by applying constraints on Euler vectors of major tectonic plates. The difference between model and observed surface deformation near the Magallanes Fagnano Fault System (MFS) is reduced by considering finite dip in the forward model. For this tectonic boundary global plate circuits models predict relative movements between 7 and 9 mm yr- 1, while our regional model indicates that a strike-slip rate of 5.9 ± 0.2 mm yr- 1 is accommodated across the MFS. Our results indicate faults dipping 66- 4+ 6° southward, locked to a depth of 11- 5+ 5 km, which are consistent with geological models for the MFS. However, normal slip also dominates the fault perpendicular motion throughout the eastern MFS, with a maximum rate along the Fagnano Lake.
Efficient Monte Carlo and greedy heuristic for the inference of stochastic block models
Peixoto, Tiago P
2014-01-01
We present an efficient algorithm for the inference of stochastic block models in large networks. The algorithm can be used as an optimized Markov chain Monte Carlo (MCMC) method, with a fast mixing time and a much reduced susceptibility to getting trapped in metastable states, or as a greedy agglomerative heuristic, with an almost linear $O(N\\ln^2N)$ complexity, where $N$ is the number of nodes in the network, independent on the number of blocks being inferred. We show that the heuristic is capable of delivering results which are indistinguishable from the more exact and numerically expensive MCMC method in many artificial and empirical networks, despite being much faster. The method is entirely unbiased towards any specific mixing pattern, and in particular it does not favor assortative community structures.
Fem Modelling and Analysis of Reinforced Concrete Section with Light Weight Blocks Infill
T. Subramani
2014-06-01
Full Text Available In an attempt to reduce the self weight of reinforced concrete structures, a new development of lightweight sandwich reinforced concrete (LSRC section has been proposed as an alternative option to solid section. LSRC section is a reinforced concrete section which contains lightweight blocks as infill material. An experimental investigation into the strength of LSRC beams has shown promising results under flexural tests. To ensure the serviceability of LSRC members under service load, it is necessary to accurately predict the cracking and deflection of this section. This paper will focus on analysing the behaviour of the tested beam specimens after cracking occurs. ANSYS 12.1 was employed to study the crack propagation of LSRC beams under bending. The numerical model shows the crack in the area of AAC blocks which associates with the brittle failure of LSRC beams. The crack propagation of the beams analysed by ANSYS agrees well with the results from the experimental investigation.
A. Soloviev
2008-02-01
Full Text Available The b-value change in the frequency-magnitude (FM distribution for a synthetic earthquake catalogue obtained by means of the model of block structure dynamics has been studied. The catalogue is divided into time periods preceding strong earthquakes and time periods that do not precede strong earthquakes. The separate analysis of these periods shows that the b-value is smaller before strong earthquakes. The similar phenomenon has been found also for the observed seismicity of the Southern California. The model of block structure dynamics represents a seismic region as a system of perfectly rigid blocks divided by infinitely thin plane faults. The blocks interact between themselves and with the underlying medium. The system of blocks moves as a consequence of prescribed motion of the boundary blocks and of the underlying medium. As the blocks are perfectly rigid, all deformation takes place in the fault zones and at the block base in contact with the underlying medium. Relative block displacements take place along the fault zones. Block motion is defined so that the system is in a quasistatic equilibrium state. The interaction of blocks along the fault zones is viscous-elastic ("normal state" while the ratio of the stress to the pressure remains below a certain strength level. When the critical level is exceeded in some part of a fault zone, a stress-drop ("failure" occurs (in accordance with the dry friction model, possibly causing failure in other parts of the fault zones. These failures produce earthquakes. Immediately after the earthquake and for some time after, the affected parts of the fault zones are in a state of creep. This state differs from the normal state because of a faster growth of inelastic displacements, lasting until the stress falls below some other level. This numerical simulation gives rise a synthetic earthquake catalogue.
Wang, Xinsheng; Wang, Chenxu; Yu, Mingyan
2016-07-01
In this paper, we propose a generalised sub-block structure preservation interconnect model order reduction (MOR) technique based on the swarm intelligence method, that is, particle swarm optimisation (PSO). The swarm intelligence-based structure preservation MOR can be used for a standard model as a criterion for different structure preservation interconnect MOR methods. In the proposed technique, the PSO method is used for predicting the unknown elements of structure-preserving reduced-order modelling of interconnect circuits. The prediction is based on minimising the difference of transform function between the original full-order and desired reduced-order systems maintaining the full-order structure in the reduced-order model. The proposed swarm-intelligence-based structure-preserving MOR method is compared with published work on structure preservation MOR SPRIM techniques. Simulation and synthesis results verify the accuracy and validity of the new structure-preserving MOR technique.
Maximizing entropy of image models for 2-D constrained coding
Forchhammer, Søren; Danieli, Matteo; Burini, Nino; Zamarin, Marco; Ukhanova, Ann
2010-01-01
This paper considers estimating and maximizing the entropy of two-dimensional (2-D) fields with application to 2-D constrained coding. We consider Markov random fields (MRF), which have a non-causal description, and the special case of Pickard random fields (PRF). The PRF are 2-D causal finite context models, which define stationary probability distributions on finite rectangles and thus allow for calculation of the entropy. We consider two binary constraints and revisit the hard square const...
We study conformational properties of a single multiblock copolymer chain consisting of flexible and semiflexible blocks. Monomer units of different blocks are equivalent in the sense of the volume interaction potential, but the intramolecular bending potential between successive bonds along the chain is different. We consider a single flexible-semiflexible regular multiblock copolymer chain with equal content of flexible and semiflexible units and vary the length of the blocks and the stiffness parameter. We perform flat histogram type Monte Carlo simulations based on the Wang-Landau approach and employ the bond fluctuation lattice model. We present here our data on different non-trivial globular morphologies which we have obtained in our model for different values of the block length and the stiffness parameter. We demonstrate that the collapse can occur in one or in two stages depending on the values of both these parameters and discuss the role of the inhomogeneity of intraglobular distributions of monomer units of both flexible and semiflexible blocks. For short block length and/or large stiffness the collapse occurs in two stages, because it goes through intermediate (meta-)stable structures, like a dumbbell shaped conformation. In such conformations the semiflexible blocks form a cylinder-like core, and the flexible blocks form two domains at both ends of such a cylinder. For long block length and/or small stiffness the collapse occurs in one stage, and in typical conformations the flexible blocks form a spherical core of a globule while the semiflexible blocks are located on the surface and wrap around this core.
Excitation block in a nerve fibre model owing to potassium-dependent changes in myelin resistance
Brazhe, Alexey; Maksimov, G. V.; Mosekilde, Erik; Sosnovtseva, O. V.
2011-01-01
. Uptake of potassium leads to Schwann cell swelling and myelin restructuring that impacts the electrical properties of the myelin. In order to further understand the dynamic interaction that takes place between the myelin and the axon, we have modelled submyelin potassium accumulation and related changes...... in myelin resistance during prolonged high-frequency stimulation. We predict that potassium-mediated decrease in myelin resistance leads to a functional excitation block with various patterns of altered spike trains. The patterns are found to depend on stimulation frequency and amplitude and to range...
Final report of the TRUE Block Scale project. 1. Characterisation and model development
Andersson, Peter; Byegaard, Johan [Geosigma AB, Uppsala (Sweden); Dershowitz, Bill; Doe, Thomas [Golder Associates Inc., Redmond, WA (United States); Hermanson, Jan [Golder Associates AB (Sweden); Meier, Peter [ANDRA, Chatenay-Malabry (France); Tullborg, Eva-Lena [Terralogica AB (Sweden); Winberg, Anders (ed.) [Conterra AB, Partille (Sweden)
2002-04-01
The general objectives of the TRUE Block Scale Project were to 1) increase understanding of tracer transport in a fracture network and to improve predictive capabilities, 2) assess the importance of tracer retention mechanisms (diffusion and sorption) in a fracture network, and 3) assess the link between flow and transport data as a means for predicting transport phenomena. During the period mid 1996 through mid 1999 a 200x250x100 m rock volume was characterised with the purpose of furnishing the basis for successful tracer experiments in a network of conductive structures in the block scale (10-100 m). In total five cored boreholes were drilled as part of the project in an iterative mode with a period of analysis following completion of characterisation, and with a strong component of inter activity with numerical modelling and experimental design, particularly towards the end of the characterisation. The combined use of pressure responses due to drilling and drilling records provided important early information/confirmation of the existence and location of a given structure. Verification of conductors identified from pressure responses was achieved through the use of various flow logging techniques. The usage of the Posiva difference flow log towards the end of the characterisation work enabled identification of discrete conductive fractures with a high resolution. Pressure responses collected during drilling were used to obtain a first assessment of connectivity between boreholes. The transient behaviour of the responses collected during cross-hole interference tests in packed-off boreholes were used to identify families of responses, which correlated well with the identified principal families of structures/fracture networks. The conductive geometry of the investigated rock block is made up of steeply dipping deterministic NW structures and NNW structures. High inflows in the boreholes were for the most part associated with geologically/geometrically identified
LEE Hyeon-deok; SON Myeong-jo; OH Min-jae; LEE Hyung-woo; KIM Tae-wan
2012-01-01
In early 2000,large domestic shipyards introduced shipbuilding 3D computer-aided design (CAD)to the hull production design process to define manufacturing and assembly information.The production design process accounts for most of the man-hours (M/H) of the entire design process and is closely connected to yard production because designs must take into account the production schedule of the shipyard,the current state of the dock needed to mount the ship's block,and supply information.Therefore,many shipyards are investigating the complete automation of the production design process to reduce the M/H for designers.However,these problems are still currently unresolved,and a clear direction is needed for research on the automatic design base of manufacturing rules,batches reflecting changed building specifications,batch updates of boundary information for hull members,and management of the hull model change history to automate the production design process.In this study,a process was developed to aid production design engineers in designing a new ship's hull block model from that of a similar ship previously built,based on AVEVA Marine.An automation system that uses the similar ship's hull block model is proposed to reduce M/H and human errors by the production design engineer.First,scheme files holding important information were constructed in a database to automatically update hull block model modifications.Second,for batch updates,the database's table,including building specifications and the referential integrity of a relational database were compared.In particular,this study focused on reflecting the frequent modification of building specifications and regeneration of boundary information of the adjacent panel due to changes in a specific panel.Third,the rollback function is proposed in which the database (DB) is used to return to the previously designed panels.
Dhont, Damien; Monod, Bernard; Hervouët, Yves; Backé, Guillaume; Klarica, Stéphanie; Choy, José E.
2012-11-01
The Venezuelan Andes form a N50°E-trending mountain belt extending from the Colombian border in the SW to the Caribbean Sea in the NE. The belt began to rise since the Middle Miocene in response to the E-W collision between the Maracaibo block to the NW and the Guyana shield belonging to South America to the SE. This oblique collision led to strain partitioning with (1) shortening along opposite-vergent thrust fronts, (2) right-lateral slip along the Boconó fault crossing the belt more or less along-strike and (3) crustal escape of the Trujillo block moving towards the NE in between the Boconó fault and the N-S-striking left-lateral Valera fault. The geology of the Venezuelan Andes is well described at the surface, but its structure at depth remains hypothetic. We investigated the deep geometry of the Mérida Andes by a 3D model newly developed from geological and geophysical data. The 3D fault model is restricted to the crust and is mainly based on the surface data of outcropping fault traces. The final model reveals the orogenic float concept where the mountain belt is decoupled from its underlying lithosphere over a horizontal décollement located either at the upper/lower crust boundary. The reconstruction of the Boconó and Valera faults results in a 3D shape of the Trujillo block, which floats over a mid-crustal décollement horizon emerging at the Boconó-Valera triple junction. Motion of the Trujillo block is accompanied by a widespread extension towards the NE accommodated by normal faults with listric geometries such as for the Motatan, Momboy and Tuñame faults. Extension is explained by the gravitational spreading of the upper crust during the escape process.
Evaluation of subgrid-scale models in large-eddy simulation of flow past a two-dimensional block
Highlights: • Large-eddy simulations of flow past a 2D block were performed. • Four subgrid-scale models were evaluated against wind tunnel experimental data. • The recently-developed modulated gradient model (MGM) shows the best overall results. • This study is the first time to validate the MGM in recirculating flows. • Analysis of TKE budget in the flow shows strong TKE production above the block. -- Abstract: Large-eddy simulations of flow past a two-dimensional (2D) block were performed to evaluate four subgrid-scale (SGS) models: (i) the traditional Smagorinsky model, (ii) the Lagrangian dynamic model, (iii) the Lagrangian scale-dependent dynamic model, and (iv) the modulated gradient model. An immersed boundary method was employed to simulate the 2D block boundaries on a uniform Cartesian grid. The sensitivity of the simulation results to grid refinement was investigated by using four different grid resolutions. The velocity streamlines and the vertical profiles of the mean velocities and variances were compared with experimental results. The modulated gradient model shows the best overall agreement with the experimental results among the four SGS models. In particular, the flow recirculation, the reattachment position and the vertical profiles are accurately reproduced with a relative coarse grid resolution of (Nx × Ny × Nz=) 160 × 40 × 160 (nx × nz = 13 × 16 covering the block). Besides the modulated gradient model, the Lagrangian scale-dependent dynamic model is also able to give reasonable prediction of the flow statistics with some discrepancies compared with the experimental results. Relatively poor performance by the Lagrangian dynamic model and the Smagorinsky model is observed, with simulated recirculating patterns that differ from the measured ones. Analysis of the turbulence kinetic energy (TKE) budget in this flow shows evidence of a strong production of TKE in the shear layer that forms as the flow is deflected around the block
Exploring Mixed Membership Stochastic Block Models via Non-negative Matrix Factorization
Peng, Chengbin
2014-12-01
Many real-world phenomena can be modeled by networks in which entities and connections are represented by nodes and edges respectively. When certain nodes are highly connected with each other, those nodes forms a cluster, which is called community in our context. It is usually assumed that each node belongs to one community only, but evidences in biology and social networks reveal that the communities often overlap with each other. In other words, one node can probably belong to multiple communities. In light of that, mixed membership stochastic block models (MMB) have been developed to model those networks with overlapping communities. Such a model contains three matrices: two incidence matrices indicating in and out connections and one probability matrix. When the probability of connections for nodes between communities are significantly small, the parameter inference problem to this model can be solved by a constrained non-negative matrix factorization (NMF) algorithm. In this paper, we explore the connection between the two models and propose an algorithm based on NMF to infer the parameters of MMB. The proposed algorithms can detect overlapping communities regardless of knowing or not the number of communities. Experiments show that our algorithm can achieve a better community detection performance than the traditional NMF algorithm. © 2014 IEEE.
A sandpile model of grain blocking and consequences for sediment dynamics in step-pool streams
Molnar, P.
2012-04-01
Coarse grains (cobbles to boulders) are set in motion in steep mountain streams by floods with sufficient energy to erode the particles locally and transport them downstream. During transport, grains are often blocked and form width-spannings structures called steps, separated by pools. The step-pool system is a transient, self-organizing and self-sustaining structure. The temporary storage of sediment in steps and the release of that sediment in avalanche-like pulses when steps collapse, leads to a complex nonlinear threshold-driven dynamics in sediment transport which has been observed in laboratory experiments (e.g., Zimmermann et al., 2010) and in the field (e.g., Turowski et al., 2011). The basic question in this paper is if the emergent statistical properties of sediment transport in step-pool systems may be linked to the transient state of the bed, i.e. sediment storage and morphology, and to the dynamics in sediment input. The hypothesis is that this state, in which sediment transporting events due to the collapse and rebuilding of steps of all sizes occur, is analogous to a critical state in self-organized open dissipative dynamical systems (Bak et al., 1988). To exlore the process of self-organization, a cellular automaton sandpile model is used to simulate the processes of grain blocking and hydraulically-driven step collapse in a 1-d channel. Particles are injected at the top of the channel and are allowed to travel downstream based on various local threshold rules, with the travel distance drawn from a chosen probability distribution. In sandpile modelling this is a simple 1-d limited non-local model, however it has been shown to have nontrivial dynamical behaviour (Kadanoff et al., 1989), and it captures the essence of stochastic sediment transport in step-pool systems. The numerical simulations are used to illustrate the differences between input and output sediment transport rates, mainly focussing on the magnification of intermittency and
Xiaoqing Ren; Jielin Pu; Shu Zhang; Liang Meng; Fangzheng Wang
2007-01-01
Objective Atrioventricular block (AVB) is a common and serious arrhythmia. At present, there is no perfect method of treatment for this kind of arrhythmia. The purpose of this study was to regenerate cardiac atrioventricular conduction by autologous transplantation of bone marrow mesenchymal stem cells (MSCs), and explore new methods for therapy of atrioventricular block. Methods Eleven Mongrel canines were randomized to MSCs transplantation (n=6) or control (n=5) group. The models of permanent and complete AVB in 11 canines were established by ablating His bundle with radiofrequency technique. At 4 weeks after AVB, bone marrow was aspirated from the iliac crest. MSCs were isolated and culture-expanded by means of gradient centrifugal and adherence to growth technique, and differentiated by 5-azacytidine in vitro. Differentiated MSCs (1ml, 1.5×107cells) labeled with BrdU were autotransplanted into His bundle area of canines by direct injection in the experimental group, and 1ml DMEM in the control group. At 1-12 weeks after operation,the effects of autologous MSCs transplantation on AVB models were evaluated by electrocardiogram, pathologic and immunohistochemical staining technique. Results Compared with the control group, there was a distinct improvement in atrioventricular conduction function in the experimental group. MSCs transplanted in His bundle were differentiated into analogous conduction system cells and endothelial cells in vivo, and established gap junction with host cardiomyocytes. Conclusions The committed-induced MSCs transplanted into His bundle area could differentiate into analogous conduction system cells and improve His conduction function in canine AVB models.
Meso-scale Modeling of Block Copolymers Self-Assembly in Casting Solutions for Membrane Manufacture
Moreno Chaparro, Nicolas
2016-05-01
Isoporous membranes manufactured from diblock copolymer are successfully produced at laboratory scale under controlled conditions. Because of the complex phenomena involved, membrane preparation requires trial and error methodologies to find the optimal conditions, leading to a considerable demand of resources. Experimental insights demonstrate that the self-assembly of the block copolymers in solution has an effect on the final membrane structure. Nevertheless, the complete understanding of these multi-scale phenomena is elusive. Herein we use the coarse-grained method Dissipative Particle Dynamics to study the self-assembly of block copolymers that are used for the preparation of the membranes. To simulate representative time and length scales, we introduce a framework for model reduction of polymer chain representations for dissipative particle dynamics, which preserves the properties governing the phase equilibria. We reduce the number of degrees of freedom by accounting for the correlation between beads in fine-grained models via power laws and the consistent scaling of the simulation parameters. The coarse-graining models are consistent with the experimental evidence, showing a morphological transition of the aggregates as the polymer concentration and solvent affinity change. We show that hexagonal packing of the micelles can occur in solution within different windows of polymer concentration depending on the solvent affinity. However, the shape and size dispersion of the micelles determine the characteristic arrangement. We describe the order of crew-cut micelles using a rigid-sphere approximation and propose different phase parameters that characterize the emergence of monodisperse-spherical micelles in solution. Additionally, we investigate the effect of blending asymmetric diblock copolymers (AB/AC) over the properties of the membranes. We observe that the co-assembly mechanism localizes the AC molecules at the interface of A and B domains, and induces
Final report of the TRUE Block Scale project. 3. Modelling of flow and transport
A series of tracer experiments were performed as part of the TRUE Block Scale experiment over length scales ranging from 10 to 100 m. The in situ experimentation was preceded by a comprehensive iterative characterisation campaign - the results from one borehole was used to update descriptive models and provide the basis for continued characterisation. Apart from core drilling, various types of laboratory investigations, core logging, borehole TV imaging and various types of hydraulic tests (single hole and cross-hole) were performed. Based on the characterisation data a hydro structural model of the investigated rock volume was constructed including deterministic structures and a stochastic background fracture population, and their material properties. In addition, a generic microstructure conceptual model of the investigated structures was developed. Tracer tests with radioactive sorbing tracers performed in three flow paths were preceded by various pre-tests including tracer dilution tests, which were used to select suitable configurations of tracer injection and pumping in the established borehole array. The in situ experimentation was preceded by formulation of basic questions and associated hypotheses to be addressed by the tracer tests and the subsequent evaluation. The hypotheses included address of the validity of the hydro structural model, the effects of heterogeneity and block scale retention. Model predictions and subsequent evaluation modelling was performed using a wide variety of model concepts. These included stochastic continuum, discrete feature network and channel network models formulated in 3D, which also solved the flow problem. In addition, two 'single channel' approaches (Posiva Streamtube and LaSAR extended to the block scale) were employed. A common basis for transport was formulated. The difference between the approaches was found in how heterogeneity is accounted for, both in terms of number of different types of immobile zones included
Final report of the TRUE Block Scale project. 3. Modelling of flow and transport
Poteri, Antti [VTT Processes, Helsinki (Finland); Billaux, Daniel [Itasca Consultants SA, Ecully (France); Dershowitz, William [Golder Associates Inc., Redmond, WA (United States); Gomez-Hernandez, J. Jaime [Univ. Politecnica de Valencia (Spain). Dept. of Hydrahulic and Environmental Engineering; Cvetkovic, Vladimir [Royal Inst. of Tech., Stockholm (Sweden). Div. of Water Resources Engineering; Hautojaervi, Aimo [Posiva Oy, Olkiluoto (Finland); Holton, David [Serco Assurance, Harwell (United Kingdom); Medina, Agustin [UPC, Barcelona (Spain); Winberg, Anders (ed.) [Conterra AB, Uppsala (Sweden)
2002-12-01
A series of tracer experiments were performed as part of the TRUE Block Scale experiment over length scales ranging from 10 to 100 m. The in situ experimentation was preceded by a comprehensive iterative characterisation campaign - the results from one borehole was used to update descriptive models and provide the basis for continued characterisation. Apart from core drilling, various types of laboratory investigations, core logging, borehole TV imaging and various types of hydraulic tests (single hole and cross-hole) were performed. Based on the characterisation data a hydro structural model of the investigated rock volume was constructed including deterministic structures and a stochastic background fracture population, and their material properties. In addition, a generic microstructure conceptual model of the investigated structures was developed. Tracer tests with radioactive sorbing tracers performed in three flow paths were preceded by various pre-tests including tracer dilution tests, which were used to select suitable configurations of tracer injection and pumping in the established borehole array. The in situ experimentation was preceded by formulation of basic questions and associated hypotheses to be addressed by the tracer tests and the subsequent evaluation. The hypotheses included address of the validity of the hydro structural model, the effects of heterogeneity and block scale retention. Model predictions and subsequent evaluation modelling was performed using a wide variety of model concepts. These included stochastic continuum, discrete feature network and channel network models formulated in 3D, which also solved the flow problem. In addition, two 'single channel' approaches (Posiva Streamtube and LaSAR extended to the block scale) were employed. A common basis for transport was formulated. The difference between the approaches was found in how heterogeneity is accounted for, both in terms of number of different types of immobile zones
3-D seismic and reservoir modeling, ram prospect, Viosca Knoll Block 912, offshore Gulf of Mexico
Carew, W.; Ostendorf, P.F. (Exxon Company, New Orleans, LA (United States)); Krum, G.K. (Exxon Exploration Company, Houston, TX (United States))
1993-09-01
Ram prospect is a large stratigraphic trap located in Viosca Knoll Block 912/956/957, offshore Alabama in 3500-ft water depth. Reservoirs are Pliocene and Miocene gas- and oil-bearing deep-water sands deposited as fan complexes in an intraslope basin. The field has been proved by a total of 12 well penetrations and is nearing the development stage. In an effort to predict reservoir performance and recovery efficiencies, we constructed three-dimensional (3-D) reservoir models Exxon's in-house 3-D modeling program (GEOSET). Reservoir simulation studies will be based upon these 3-D geological models. We used 3-D seismic data to map seismic attributes around the prospect and well control to calibrate the seismic attributes based on known reservoir characteristics, thereby deriving a facies map for the entire field. Top/base structure, gross isopach, facies polygons, porosity, and Vshale were input into GEOSET to define the overall reservoir container and fill. The paucity of well data was compensated by using the 3-D-seismic based facies as a guide to filling polygons and by creating [open quotes]pseudowells[close quotes] from the real well data. These pseudowells aided in correlating within and between polygons. The resulting 3-D models (total porosity, effective porosity, Vsand) faithfully reflect the heterogeneity inferred from both 3-D seismic data and well control and provide visualization of reservoir continuity much better than models derived from well data alone. The models serve as a framework within which one can perform reservoir simulations and run various sensitivities. Additionally, the GEOSET porosity models can provide an alternative reservoir volume calculation.
无
2007-01-01
BACKGROUND: The cerebral ischemia and ischemia/reperfusion animal models are used to simulate the human cerebrovascular diseases is one of the popular topics of neurological science recently. To study the pathophysiology, pathogenesis, prophylaxis and treatment of ischemic cerebrovascular diseases and to establish the ideal animal model that is the most similar to the human cerebral ischemia, are the topics that the people generally cared about.OBJECTIVE: To evaluate the effects of aerocyst-blocking bilateral ascending pharyngeal artery on the establishment of cerebral ischemia models by using digital subtraction angiography (DSA), magnetic resonance diffusion-weighted imaging (DWI) and magnetic resonance perfusion-weighted imaging (PWI). DESIGN: Repetitive measure animal experiment.SETTING: Zhongshan Hospital Affiliated to Dalian University.MATERIALS: The experiment was carried out in the Animal Laboratory (Provincial Laboratory),Zhongshan Hospital of Dalian Univeristy from January to May 2006. A total of 14 domestic piglets, of 6 months old, weighing 12 - 15 kg, of either gender, were selected from Animal Experimental Center, Dalian University. Multistar T.O.P digital subtraction angiography machine was provided by Siemens Company,German.METHODS: Aerocyst-blocking bilateral ascending pharyngeal artery was used to establish cerebral ischemia models. And then, Multistar T.O.P. DSA was used for imaging of cerebral vessels before blocking, during blocking and at 0.5 and 2 hours after ischemia perfusion. GE Signa 1.5 T supraconduction magnetic resonance imaging was used for DWI examination; in addition, PWI was used based on focal sites and areas.Otherwise, magnetic resonance imaging (MRI) was used to detect signal changes of T1WI and T2WI in ischemic areas.MAIN OUTCOME MEASURES: Analytic results of DSA, DWI, PWI and MRI.RESULTS: All 14 experimental piglets were involved in the final analysis. ① DSA: The blood flow of bilateral ascending pharyngeal arteries and its
A blocked takeover in the Polish power sector: A model-based analysis
As the President of the Office of Competition and Consumer Protection refused to approve a government initiated takeover in the Polish power sector and the Court of Competition and Consumer Protection did not make a ruling on that case, the takeover was finally prohibited. In this context, the main aim of this paper is to carry out a quantitative analysis of the impact of the takeover in question on electricity prices and quantities, consumer and producer surpluses, dead weight loss and emissions. The scope of the study covers the Polish power generation sector and the analysis was carried out for 2009. A game theory-based electricity market equilibrium model developed for Poland was applied. The model includes several country-specific conditions, such as a coal-based power generation fuel-mix, a large share of biomass co-combustion, etc. For the sake of clarity, only four scenarios are assumed. The paper concludes that the declared synergy savings did not compensate for the increase in dead weight loss and the transfer of surplus from consumers to producers caused by increased market power. - Highlights: • A takeover blocked by the President of the Office of Competition and Consumer Protection was analysed. • A game theory-based model of the Polish wholesale electricity market was applied. • The impact of the takeover on electricity prices and generation levels, surplus transfers and dead weight loss was estimated. • The results were compared with the declared synergy savings
The experimental validation of a transient power electronic building block (PEBB) mathematical model
This work adjusts and validates experimentally a previously developed volume element model based thermal management tool (vemESRDC) through the comparison of temperature measurements of a power electronic building block (PEBB) to numerical simulation results, featuring relevant electronic components of an all-electric ship. Primary components of interest in this simulation are: inductors, capacitors, AC and DC fuses, and a tiristors/fins set. The vemESRDC is a thermal simulation tool developed as part of the Electric Ship Research and Development Consortium (ESRDC) funded by the Office of Naval Research (ONR) that is capable of providing quick responses during early stages of ship design. The model adjustment was conducted by solving the inverse problem of parameter estimation for appropriate equipment properties using a total power dissipation of 4.8 kW in the PEBB. Next, the adjusted model was experimentally validated using the same PEBB with a power dissipation of 11.12 kW. The transient and steady state numerical results are shown to be in good quantitative and qualitative agreement with the experimental measurements within the experimental error margin. Transient simulations demonstrate that the components temperature vary significantly from one heating mode to another, whereas internal air average temperature varies only slightly for all heating modes, therefore not only average internal air temperature should be monitored for preserving equipment functionality. As a result, it is expected that vemESRDC could be used as a reliable tool for transient and steady state thermal management of heat generating packages (e.g., PEBB, future all-electric ship). -- Highlights: • We amended and tested a general computational model for electronic packages. • Experimental and numerical results are in good quantitative and qualitative agreement. • A transient simulation study was conducted with the model. • The system thermal conductance was determined and
N.M. Ghasem
2003-12-01
Full Text Available In this paper, the simulink block diagram is used to solve a model consists of a set of ordinary differential and algebraic equations to control the temperature inside a simple stirred tank heater. The flexibility of simulink block diagram gives students a better understanding of the control systems. The simulink also allows solution of mathematical models and easy visualization of the system variables. A polyethylene fluidized bed reactor is considered as an industrial example and the effect of the Proportional, Integral and Derivative control policy is presented for comparison.
A seismically active region is represented as a system of absolutely rigid blocks divided by infinitely thin plane faults. The interaction of the blocks along the fault planes and with the underlying medium is viscous-elastic. The system of blocks moves as a consequence of prescribed motion of boundary blocks and the underlying medium. When for some part of a fault plane the stress surpasses a certain strength level a stress-drop (''a failure'') occurs. It can cause a failure for other parts of fault planes. The failures are considered as earthquakes. As a result of the numerical simulation a synthetic earthquake catalogue is produced. This procedure is applied for numerical modeling of dynamics of the block structure approximating the tectonic structure of the Vrancea region. By numerical experiments the values of the model parameters were obtained which supplied the synthetic earthquake catalog with the space distribution of epicenters close to the real distribution of the earthquake epicenters in the Vrancea region. The frequency-magnitude relations (Gutenberg-Richter curves) obtained for the synthetic and real catalogs have some common features. The sequences of earthquakes arising in the model are studied for some artificial structures. It is found that ''foreshocks'', ''main shocks'', and ''aftershocks'' could be detected among earthquakes forming the sequences. The features of aftershocks, foreshocks, and catalogs of main shocks are analysed. (author). 5 refs, 12 figs, 16 tabs
Modeling interactions between blocking and permeant cations in the NavMs channel.
Korkosh, Vyacheslav S; Zhorov, Boris S; Tikhonov, Denis B
2016-06-01
Mechanisms of sodium channel block by local anesthetics (LAs) are still a matter of intensive studies. In the absence of high-resolution structures of eukaryotic channels, atomic details of LA-channel interactions are analyzed using homology modeling. LAs are predicted to access the closed channel through a sidewalk (fenestration) between the channel repeats, bind in a horizontal orientation, and leave its aromatic moiety in the interface. Recent X-ray structure of a bacterial sodium channel NavMs with a cationic molecule Pl1, which is structurally similar to LAs, has confirmed this theoretical prediction and demonstrated a reduced selectivity filter occupancy by the permeant ions in the Pl1-bound channel. However, the nature of the antagonism between LAs and permeant ions is still unclear. Here we used the NavMs structure and Monte Carlo energy minimizations to model Pl1 binding. Our computations predict that Pl1 can displace permeant ion(s) from the selectivity filter by both steric and electrostatic mechanisms. We hypothesize that the electrostatic mechanism is more general, because it is applicable to many LAs and related drugs, which lack a moiety capable to enter the selectivity filter and sterically displace the permeant ion. The electrostatic mechanism is also consistent with the data that various cationic blockers of potassium channels bind in the inner pore without entering the selectivity filter. PMID:27020546
Automation of block assignment planning using a diagram-based scenario modeling method
Hwang In Hyuck
2014-03-01
Full Text Available Most shipbuilding scheduling research so far has focused on the load level on the dock plan. This is be¬cause the dock is the least extendable resource in shipyards, and its overloading is difficult to resolve. However, once dock scheduling is completed, making a plan that makes the best use of the rest of the resources in the shipyard to minimize any additional cost is also important. Block assignment planning is one of the midterm planning tasks; it assigns a block to the facility (factory/shop or surface plate that will actually manufacture the block according to the block characteristics and current situation of the facility. It is one of the most heavily loaded midterm planning tasks and is carried out manu¬ally by experienced workers. In this study, a method of representing the block assignment rules using a diagram was su¬ggested through analysis of the existing manual process. A block allocation program was developed which automated the block assignment process according to the rules represented by the diagram. The planning scenario was validated through a case study that compared the manual assignment and two automated block assignment results.
A series of hydrologic tests have been conducted at the Stripa research mine in Sweden to develop hydrologic characterization techniques for rock masses in which fractures form the primary flow paths. The structural studies reported here were conducted to aid in the hydrologic examination of a cubic block of granite with dimensions of 150 m on a side. This block (the SCV block) is located between the 310- and 460-m depth levels at the Stripa mine. This report describes and interprets the fracture system geology at Stripa as revealed in drift exposures, checks the interpretive model against borehole records and discusses the hydrologic implication of the model, and examines the likely effects of stress redistribution around a drift (the Validation drift) on inflow to the drift along a prominent fracture zone. (72 refs.) (au)
Martel, S.J.
1992-04-01
A series of hydrologic tests have been conducted at the Stripa research mine in Sweden to develop hydrologic characterization techniques for rock masses in which fractures form the primary flow paths. The structural studies reported here were conducted to aid in the hydrologic examination of a cubic block of granite with dimensions of 150 m on a side. This block (the SCV block) is located between the 310- and 460-m depth levels at the Stripa mine. this report describes and interprets the fracture system geology at Stripa as revealed in drift exposures, checks the interpretive model against borehole records and discusses the hydrologic implications of the model, and examines the likely effects of stress redistribution around a drift (the Validation drift) on inflow to the drift along a prominent fracture zone.
Laine, E. P.; Field, C.
2010-12-01
The Campus Compact for New Hampshire (Gordon, 2003) introduced a practical model for designing service-learning exercises or components for new or existing courses. They divided the design and implementation process into eight concrete areas, the “8-Block Model”. Their goal was to demystify the design process of service learning courses by breaking it down into interconnected components. These components include: project design, community partner relations, the problem statement, building community in the classroom, building student capacity, project management, assessment of learning, and reflection and connections. The project design component of the “8-Block Model” asks that the service performed be consistent with the learning goals of the course. For science courses students carry out their work as a way of learning science and the process of science, not solely for the sake of service. Their work supports the goals of a community partner and the community partner poses research problems for the class in a letter on their letterhead. Linking student work to important problems in the community effectively engages students and encourages them to work at more sophisticated levels than usually seen in introductory science classes. Using team-building techniques, the classroom becomes a safe, secure learning environment that encourages sharing and experimentation. Targeted lectures, labs, and demonstrations build the capacity of students to do their research. Behind the scenes project management ensures student success. Learning is assessed using a variety of tools, including graded classroom presentations, poster sessions, and presentations and reports to community partners. Finally, students reflect upon their work and make connections between their research and its importance to the well being of the community. Over the past 10 years, we have used this approach to design and continually modify an introductory oceanography course for majors and non
Rojas, G.; Simon, C.; Capoferri, E.; Redaelli, M.; Marcano, E. [Eni Venezuela B.V., Caracas (Venezuela, Bolivarian Republic of); Solorzano, E. [PDVSA Petroleos de Venezuela SA, Caracas (Venezuela, Bolivarian Republic of). CVP
2009-07-01
The presence of oil in Venezuela's Orinoco heavy oil belt has been known since the 1930's, but the first rigorous evaluation of the resource was only made in the 1980's and revised in 2005. The Faja Petrolifera del Orinoco (FPO) has been divided into 4 areas, namely the Boyaca (6 blocks), Junin (11 blocks), Ayacucho (7 blocks) and Carabobo (4 blocks). The Junin 5 block covers a surface area of 672 km{sup 2} and consists of extra-heavy oil accumulations with an average API gravity of 8. Field static and dynamic models were generated as part of a joint study agreement between PDVSA and Eni Venezuela that included the quantification and the certification of stock tank oil initially in place (STOIIP). A reservoir analysis was performed based on original geophysical, petrophysical, stratigraphic and sedimentological studies. The Cretaceous to Oligo-Miocene reservoir sequence consists of a complex mix of fluvial and tidal delta facies interbedded with alluvial and coastal plain non-reservoir intervals. Structurally, the sequence consists of a faulted monocline dipping north-northeast and onlapping southwards onto Paleozoic meta-sediments. The 6 petrophysical facies include coarse-medium sand, fine-medium sand, heterolithic deposits, coal, tight facies and shale. A relationship between petrophysical facies derived from electric logs and sedimentological facies described from bottom-hole cores was found. At least 15 hydraulic units were defined in the whole sequence. All the results of the reservoir analysis were integrated into a geo-cellular model of the whole Junin 5 block. The STOIIP of the Junin 5 block, which was computed taking into account all the pay facies, was found to be 39,416 MMSTB. The most important reservoirs are the Arenas Basales and the Oligocene which contain more than 85 per cent of the oil volume. 12 refs., 1 tab., 14 figs.
Sébastien, Haffen; Yves, Géraud; Marc, Diraison; Chrystel, Dezayes
2013-04-01
Buntsandstein sandstones (upper Permian to middle Triassic), located in the Upper Rhine Graben, appear as an easy target for geothermal exploitation: this reservoir links more or less permeable argillaceous sandstones, intersected by many major faults, to the regional thermal anomaly. In this context, we propose a conceptual geological 3-D block model of the Buntsandstein reservoir which could be used as a guide for future regional geothermal exploration or exploitation. This block presents the Buntsandstein sandstones reservoir at depth with different sedimentary facies (braided rivers, playa lake and fluvio-aeolian), above the Palaeozoic Granit and below the Muschelkalk limestones, intersecting by faults oriented according regional major azimuths: (1) ≈N020°E, corresponding to Rhenish faults and (2) ≈N060°E (or ≈N130°E) corresponding to Hercynian reactivated faults. Petrophysical properties of the reservoir are both controlled by matrix and faults/fractures characteristics. (1) Matrix properties (porosity, permeability, thermal conductivity, Pwaves velocity) have been determined from petrophysical measurements performed on cores of 15 borehole, mainly on borehole EPS1 (Soultz-sous-Forêts, France), continuously cored through Buntsandstein; (2) from thermal gradient analyses based on thermal conductivity measurements on core samples and also from borehole temperature logs run in the same borehole. This last approach allows locating fluid flow and thus permeability at reservoir scale. The flow paths appear as a composite network controlled by 'sedimentary' permeability on one hand and by 'fracture' permeability on the other. Fracturing associated with major fault zones provide pathways for the upward flowing fluids to connect with stratigraphic levels characterized by high matrix permeability and no impermeable macroscopic layers. This is why the Playa Lake and Fluvio-aeolian marginal erg facies provide a reservoir connected to a deep hot fluid source
Pichai Aree
2005-01-01
The transfer-function block-diagram model of single-machine infinite-bus power system has been a popular analytical tool amongst power engineers for explaining and assessing synchronous generator dynamic behaviors. In previous studies, the effects of local load together with damper circuit on generator damping have not yet been addressed because neither of them was integrated into this model. Since the model only accounts for the generator main field circuit, it may not always yield a realist...
Peters, Andrew J.; Lawson, Richard A.; Nation, Benjamin D.; Ludovice, Peter J.; Henderson, Clifford L.
2016-01-01
State-of-the-art block copolymer (BCP)-directed self-assembly (DSA) methods still yield defect densities orders of magnitude higher than is necessary in semiconductor fabrication despite free-energy calculations that suggest equilibrium defect densities are much lower than is necessary for economic fabrication. This disparity suggests that the main problem may lie in the kinetics of defect removal. This work uses a coarse-grained model to study the rates, pathways, and dependencies of healing a common defect to give insight into the fundamental processes that control defect healing and give guidance on optimal process conditions for BCP-DSA. It is found that bulk simulations yield an exponential drop in defect heal rate above χN˜30. Thin films show no change in rate associated with the energy barrier below χN˜50, significantly higher than the χN values found previously for self-consistent field theory studies that neglect fluctuations. Above χN˜50, the simulations show an increase in energy barrier scaling with 1/2 to 1/3 of the bulk systems. This is because thin films always begin healing at the free interface or the BCP-underlayer interface, where the increased A-B contact area associated with the transition state is minimized, while the infinitely thick films cannot begin healing at an interface.
Ketones block amyloid entry and improve cognition in an Alzheimer's model.
Yin, Jun Xiang; Maalouf, Marwan; Han, Pengcheng; Zhao, Minglei; Gao, Ming; Dharshaun, Turner; Ryan, Christopher; Whitelegge, Julian; Wu, Jie; Eisenberg, David; Reiman, Eric M; Schweizer, Felix E; Shi, Jiong
2016-03-01
Sporadic Alzheimer's disease (AD) is responsible for 60%-80% of dementia cases, and the most opportune time for preventive intervention is in the earliest stage of its preclinical phase. As traditional mitochondrial energy substrates, ketone bodies (ketones, for short), beta-hydroxybutyrate, and acetoacetate, have been reported to provide symptomatic improvement and disease-modifying activity in epilepsy and neurodegenerative disorders. Recently, ketones are thought as more than just metabolites and also as endogenous factors protecting against AD. In this study, we discovered a novel neuroprotective mechanism of ketones in which they blocked amyloid-β 42, a pathologic hallmark protein of AD, entry into neurons. The suppression of intracellular amyloid-β 42 accumulation rescued mitochondrial complex I activity, reduced oxidative stress, and improved synaptic plasticity. Most importantly, we show that peripheral administration of ketones significantly reduced amyloid burden and greatly improved learning and memory ability in a symptomatic mouse model of AD. These observations provide us insights to understand and to establish a novel therapeutic use of ketones in AD prevention. PMID:26923399
Wang, Tingting; Dai, Weidi; Jiao, Pengfei; Wang, Wenjun
2016-05-01
Many real-world data can be represented as dynamic networks which are the evolutionary networks with timestamps. Analyzing dynamic attributes is important to understanding the structures and functions of these complex networks. Especially, studying the influential nodes is significant to exploring and analyzing networks. In this paper, we propose a method to identify influential nodes in dynamic social networks based on identifying such nodes in the temporal communities which make up the dynamic networks. Firstly, we detect the community structures of all the snapshot networks based on the degree-corrected stochastic block model (DCBM). After getting the community structures, we capture the evolution of every community in the dynamic network by the extended Jaccard’s coefficient which is defined to map communities among all the snapshot networks. Then we obtain the initial influential nodes of the dynamic network and aggregate them based on three widely used centrality metrics. Experiments on real-world and synthetic datasets demonstrate that our method can identify influential nodes in dynamic networks accurately, at the same time, we also find some interesting phenomena and conclusions for those that have been validated in complex network or social science.
Molecular Dynamics Modelling of Block-Copolymer Electrolytes with High t+ Values
Molecular Dynamics simulations of the BAB type triblock copolymer lithium poly[(4-styrenesulfonyl) (trifluoromethylenesulfonyl) imide)]-block-poly(ethylene oxide)-block-lithium poly[(4-stryrenesylfonyl) (trifluoromethanesulfonyl) imide] (P(STFSILi)-b-PEO-b-P(STFSILi)) were carried out for different simulation temperatures and B-block lengths. By covalently binding the anion to the polymer backbone, it is immobilised and the cation transference number thereby raised significantly. It was found that the Li-ion diffusion decreases exponentially with growth of the B-block length. The poly(ethylene oxide) matrix dissolves Li-ions already during the equilibration stage of the simulation, and no Li-ion diffusion pathways were identified along the STFSI branches, which significantly influence the transport properties of the material
Contemporary crustal deformation of the Chinese continent and tectonic block model
WANG; Min; (王; 敏); SHEN; Zhengkang; (沈正康); NIU; Zhijun; (牛之俊); ZHANG; Zusheng; (张祖胜); SUN; Hanrong; (孙汉荣); GAN; Weijun; (甘卫军); WANG; Qi; (王; 琪); REN; Qun; (任; 群)
2003-01-01
We obtain the preliminary result of crustal deformation velocity field for the Chinese con-tinent by analyzing GPS data from the Crustal Motion Observation Network of China (CMONOC), particularly the data from the regional networks of CMONOC observed in 1999 and 2001. We de-lineate 9 tectonically active blocks and 2 broadly distributed deformation zones out of a denseGPS velocity field, and derive block motion Euler poles for the blocks and their relative motionrates. Our result reveals that there are 3 categories of deformation patterns in the Chinese conti-nent. The first category, associated with the interior of the Tibetan Plateau and the Tianshan oro-genic belt, shows broadly distributed deformation within the regions. The third category, associatedwith the Tarim Basin and the region east of the north-south seismic belt of China, shows block-likemotion, with deformation accommodated along the block boundaries only. The second category, mainly associated with the borderland of the Tibetan Plateau, such as the Qaidam, Qilian, Xining(in eastern Qinghai), and the Diamond-shaped (in western Sichuan and Yunnan) blocks, has thedeformation pattern between the first and the third, i.e. these regions appear to deform block-like,but with smaller sizes and less strength for the blocks. Based on the analysis of the lithosphericstructures and the deformation patterns of the regions above, we come to the inference that thedeformation modes of the Chinese continental crust are mainly controlled by the crustal structure.The crust of the eastern China and the Tarim Basin is mechanically strong, and its deformationtakes the form of relative motion between rigid blocks. On the other hand, the northward indentation of the Indian plate into the Asia continent has created the uplift of the Tibetan Plateau and the Tianshan Mountains, thickened their crust, and raised the temperature in the crust. The lower crust thus has become ductile, evidenced in low seismic velocity and high
Modeling of HDD Head Positioning Systems Regarded as Robot Manipulators Using Block Matrices
Trawinski, Tomasz; Witula, Roman
2010-01-01
The formulated dynamics block matrix of multilayer head positioning system consist of submatrixes which are related directly with structure of his kinematic chain. The dynamic block matrix consists of: bough self inertial matrix, self inertial matrix of branches, branch-bough inertial coupling matrix. The bough self inertial matrix is always one by one dimensional. But this matrix is very sensitive for increase of numbers of branches, adding one new branch into kinematic chains it result in t...
Phosphogypsum is a by-product from the phosphate fertilizer industry and its large-scale utilization as an alternative construction material copes with radiological issues related to radon-222. Zero-order models for radon-222 exhalation from phosphogypsum building blocks and its time-varying accumulation in closed domains (e.g. indoor accumulation) presume homogeneous distribution of radon-222 throughout the enclosure. Having in mind radiological protection design, exhalation characterization of a block sample is a valuable parameter for the corresponding building performance simulation and it can be accomplished by placing a test block inside a test chamber together with a suitable nuclear detector (their relative positioning depends on the chamber geometry). As breakdown of the uniform concentration hypothesis is likely to occur, this preliminary work numerically investigates such model oversimplification. Along with emanation and decay processes, the present mathematical model assumes time-dependent two-dimensional diffusion-dominant mass transfer in a domain containing a sample of porous material, namely the phosphogypsum block of finite thickness. Conversely, as the test chamber is quite small and air-tight closed, convective mass transfer is neglected. Numerically simulated results have confirmed that a non-uniform radon-222 distribution takes place, which can obviously influence the position of the nuclear detector (or its primary element), thus affecting its readings. (author)
A Physics-Based Charge-Control Model for InP DHBT Including Current-Blocking Effect
GE Ji; JIN Zhi; SU Yong-Bo; CHENG Wei; WANG Xian-Wai; CHEN Gao-Peng; LIU Xin-Yu
2009-01-01
We develop a physics-based charge-control InP double heterojunction bipolar transistor model including three important effects: current blocking, mobile-charge modulation of the base-collector capacitance and velocity-field modulation in the transit time. The bias-dependent base-collector depletion charge is obtained analytically, which takes into account the mobile-charge modulation. Then, a measurement based voltage-dependent transit time formulation is implemented. As a result, over a wide range of biases, the developed model shows good agreement between the modeled and measured S-parameters and cutoff frequency. Also, the model considering current blocking effect demonstrates more accurate prediction of the output characteristics than conventional vertical bipolar inter company results.
2016-01-01
Purpose The aim of this study was to present new a model that allows the study of the bone healing process, with an emphasis on the biological behavior of different graft-to-host interfaces. A standardized “over-inlay” surgical technique combined with a differential histomorphometric analysis is presented in order to optimize the use of critical-size calvarial defects in pre-clinical testing. Methods Critical-size defects were created into the parietal bone of 8 male Wistar rats. Deproteinized bovine bone (DBBM) blocks were inserted into the defects, so that part of the block was included within the calvarial thickness and part exceeded the calvarial height (an “over-inlay” graft). All animals were sacrificed at 1 or 3 months. Histomorphometric and immunohistochemical evaluation was carried out within distinct regions of interest (ROIs): the areas adjacent to the native bone (BA), the periosteal area (PA) and the central area (CA). Results The animals healed without complications. Differential morphometry allowed the examination of the tissue composition within distinct regions: the BA presented consistent amounts of new bone formation (NB), which increased over time (24.53%±1.26% at 1 month; 37.73%±0.39% at 3 months), thus suggesting that this area makes a substantial contribution toward NB. The PA was mainly composed of fibrous tissue (71.16%±8.06% and 78.30%±2.67%, respectively), while the CA showed high amounts of DBBM at both time points (78.30%±2.67% and 74.68%±1.07%, respectively), demonstrating a slow remodeling process. Blood vessels revealed a progressive migration from the interface with native bone toward the central area of the graft. Osterix-positive cells observed at 1 month within the PA suggested that the periosteum was a source of osteoprogenitor elements. Alkaline phosphatase data on matrix deposition confirmed this observation. Conclusions The present model allowed for a standardized investigation of distinct graft
Stratigraphic model deposit Ofi Inf SDZ-2X A1, Jun in block in Orinoco Oil belt
This work is about the Stratigraphic model deposit O fi I nf SDZ-2X A1, Junin block in Orinoco Oil belt.This model was based on a chrono stratigraphic interpretation and was defined the correlation between the main and secondary surfaces. The wells of the study area pass through the Cambrian, Cretaceous and Miocene sediments. The last is more interesting for the study because of the stratigraphic and sand body surface presence
Chen, Xuan; Goodwin, Barry K.
2012-01-01
Our study focuses on modeling wildfire damage in the State of Florida. The approach is to evaluate wildfire risks in a spatio-temporal framework. A block bootstrapping method has been proposed to construct a statistical model accounting for explanatory variables while adjusting for spatial and temporal autocorrelation. Although the bootstrap (Efron 1979) method can handle independent observations well, the strong autocorrelation of wildfire risks brings about a major challenge. Motivated by b...
Nesterenko, Vladislav V.; Zygmunt, Andrew C.; Rajamani, Sridharan; Belardinelli, Luiz; Antzelevitch, Charles
2011-01-01
Block of Na+ channel conductance by ranolazine displays marked atrial selectivity that is an order of magnitude higher that of other class I antiarrhythmic drugs. Here, we present a Markovian model of the Na+ channel gating, which includes activation-inactivation coupling, aimed at elucidating the mechanisms underlying this potent atrial selectivity of ranolazine. The model incorporates experimentally observed differences between atrial and ventricular Na+ channel gating, including a more neg...
Solid images for geostructural mapping and key block modeling of rock discontinuities
Assali, Pierre; Grussenmeyer, Pierre; Villemin, Thierry; Pollet, Nicolas; Viguier, Flavien
2016-04-01
Rock mass characterization is obviously a key element in rock fall hazard analysis. Managing risk and determining the most adapted reinforcement method require a proper understanding of the considered rock mass. Description of discontinuity sets is therefore a crucial first step in the reinforcement work design process. The on-field survey is then followed by a structural modeling in order to extrapolate the data collected at the rock surface to the inner part of the massif. Traditional compass survey and manual observations can be undoubtedly surpassed by dense 3D data such as LiDAR or photogrammetric point clouds. However, although the acquisition phase is quite fast and highly automated, managing, handling and exploiting such great amount of collected data is an arduous task and especially for non specialist users. In this study, we propose a combined approached using both 3D point clouds (from LiDAR or image matching) and 2D digital images, gathered into the concept of ''solid image''. This product is the connection between the advantages of classical true colors 2D digital images, accessibility and interpretability, and the particular strengths of dense 3D point clouds, i.e. geometrical completeness and accuracy. The solid image can be considered as the information support for carrying-out a digital survey at the surface of the outcrop without being affected by traditional deficiencies (lack of data and sampling difficulties due to inaccessible areas, safety risk in steep sectors, etc.). Computational tools presented in this paper have been implemented into one standalone software through a graphical user interface helping operators with the completion of a digital geostructural survey and analysis. 3D coordinates extraction, 3D distances and area measurement, planar best-fit for discontinuity orientation, directional roughness profiles, block size estimation, and other tools have been experimented on a calcareous quarry in the French Alps.
Marc Pudlo
2016-06-01
Full Text Available Objective: Anaphylactic reactions induced by neuromuscular blocking agents (NMBAs can occur at first contact and might be due to cross-sensitization by other drugs or chemicals. Our aim was to investigate whether divalent molecules sharing chemical features with NMBAs might potentially cause cross-sensitization. Methods: We constructed a pharmacophore key from chemical features common to all NMBAs (two positive or ionizable features 1.0807 nm apart and used the key to screen FDA-approved small drug molecules of the Drug Bank® database (1541 molecules. The selected molecules were categorized on the basis of the values for three main parameters (fit value, relative energy and mean polar surface area. Results: Screening from the pharmacophore key selected 13 NMBAs and 88 non-NMBA drugs. Of these 88 drugs, 42 had high-ranking parameter values and were considered preferential cross-sensitizers. These included the dopamine D2 receptor ligands aripiprazole and domperidone. Pholcodine, as well as nizatidine, ranitidine, antrafenine, cabergoline and, to some extent, chlorhexidine best fulfilled the required criteria of apolar character, bioavailability and ionization rate. Conclusion: Our data support the hypothesis that pholcodine might be a potential NMBA cross-sensitizer. They confirmed the results of inhibition tests on patient serum suggesting that dopamine D2 receptor ligands might be cross-sensitizers. They also identified chlorhexidine, a widely used disinfectant incriminated in several cases of immediate hypersensitivity reactions, as a potential cross-sensitizer. Pharmacophore modelling is an inexpensive, straightforward approach that can be used to identify potential NMBA cross-sensitizing agents.
Y HARI PRASADA REDDY
2012-05-01
Full Text Available In this paper, a mathematical model has been developed for group replacement of a block of Air Conditioners using discrete-time First Order Markov Chains. To make the model more realistic, threeintermediate states viz., Minor Repair State, Semi-Major Repair State and Major Repair States have been introduced between Functioning State & Complete Failure States of the system. The Transition Probabilities for future periods for First Order Markov Chain (FOMC are estimated by Spectral Decomposition Method. Using these probabilities, the number of systems in each state and accordingly the corresponding average maintenance cost is computed. The forecasted inflation for Air Conditioners and the real value of money using Fisherman’s relation are employed to study and develop the real time mathematical model for block replacement decision making.
... the signal causes the heart to contract and pump blood. Heart block occurs if the electrical signal is ... degree heart block limits the heart's ability to pump blood to the rest of the body. This type ...
Schwieger, Christian; Achilles, Anja; Scholz, Sven; Rüger, Jan; Bacia, Kirsten; Saalwaechter, Kay; Kressler, Jörg; Blume, Alfred
2014-09-01
A novel class of symmetric amphi- and triphilic (hydrophilic, lipophilic, fluorophilic) block copolymers has been investigated with respect to their interactions with lipid membranes. The amphiphilic triblock copolymer has the structure PGMA(20)-PPO(34)-PGMA(20) (GP) and it becomes triphilic after attaching perfluoroalkyl moieties (F9) to either end which leads to F(9)-PGMA(20)-PPO(34)-PGMA(20)-F(9) (F-GP). The hydrophobic poly(propylene oxide) (PPO) block is sufficiently long to span a lipid bilayer. The poly(glycerol monomethacrylate) (PGMA) blocks have a high propensity for hydrogen bonding. The hydrophobic and lipophobic perfluoroalkyl moieties have the tendency to phase segregate in aqueous as well as in hydrocarbon environments. We performed differential scanning calorimetry (DSC) measurements on polymer bound lipid vesicles under systematic variation of the bilayer thickness, the nature of the lipid headgroup, and the polymer concentration. The vesicles were composed of phosphatidylcholines (DMPC, DPPC, DAPC, DSPC) or phosphatidylethanolamines (DMPE, DPPE, POPE). We showed that GP as well as F-GP binding have membrane stabilizing and destabilizing components. PPO and F9 blocks insert into the hydrophobic part of the membrane concomitantly with PGMA block adsorption to the lipid headgroup layer. The F9 chains act as additional membrane anchors. The insertion of the PPO blocks of both GP and F-GP could be proven by 2D-NOESY NMR spectroscopy. By fluorescence microscopy we show that F-GP binding increases the porosity of POPC giant unilamellar vesicles (GUVs), allowing the influx of water soluble dyes as well as the translocation of the complete triphilic polymer and its accumulation at the GUV surface. These results open a new route for the rational design of membrane systems with specific properties. PMID:24942348
Smith, Martin H.
1992-01-01
Describes an educational game called "Population Blocks" that is designed to illustrate the concept of exponential growth of the human population and some potential effects of overpopulation. The game material consists of wooden blocks; 18 blocks are painted green (representing land), 7 are painted blue (representing water); and the remaining…
de Oliveira, Leida Calegário; Campos, Fabiana V; Figueiredo, Suely Gomes; Cordeiro, Marta N; Adaime, Beatriz R; Richardson, Michael; Pimenta, Adriano M C; Martin-Eauclaire, Marie-France; Beirão, Paulo S L; De Lima, Maria Elena
2015-09-15
A potent insecticidal toxin, β/δ-PrIT1, molecular mass of 5598.86 [M+H](+), was characterized from Phoneutria reidyi spider venom. Its partial amino acid sequence showed high similarity with insecticidal spider toxins from the genus Phoneutria. β/δ-PrIT1 was very toxic (LD50 = 4 nmol/g) to flies (Musca domestica), but not to mice (Mus musculus). Kinetic studies showed that (125)I-β/δ-PrIT1 binds to two distinct sites in insect sodium channels, with close affinity (Kd1 = 34.7 pM and Kd2 = 35.1 pM). Its association is rather fast (t1/2(1) = 1.4 min, t1/2(2) = 8.5 min) and its dissociation is a slower process (t1/2(1) = 5.4 min, t1/2(2) = 32.8 min). On rat brain synaptosomes β/δ-PrIT1 partially competed (∼30%) with the beta-toxin (125)I-CssIV, but did not compete with the alpha-toxin of reference (125)I-AaII, nor with the beta-toxin (125)I-TsVII. On cockroach nerve cord synaptosomes, β/δ-PrIT1 did not compete with the anti-insect toxin (125)I-LqqIT1, but it competed (IC50 = 80 pM) with the "alpha-like" toxin (125)I-BomIV. In cockroach neurons, β/δ-PrIT1 inhibited the inactivation of Nav-channels and it shifted the sodium channel activation to hyperpolarizing potentials. These results indicate two different binding sites for β/δ-PrIT1, leading to two different pharmacological responses. β/δ-PrIT1 is one of the most toxic spider toxins to insects without apparent toxicity to mammals, and provide new model for the development of insecticides. PMID:26220799
Realizing block planning concepts in make-and-pack production using MILP modelling and SAP APO
Günther, H.O.; Grunow, M.; Neuhaus, U.
2006-01-01
major producer of hair dyes as a case study. We present two different implementations of the block planning concept. One utilizes the Production Planning/Detailed Scheduling module of the SAP APO© software. The other approach is based on a mixed-integer linear programming formulation. In contrast to the...
LI; Shihai; LIAN; Zhenzhong; J.; G.; Wang
2005-01-01
This paper studies the stability of jointed rock slopes by using our improved three-dimensional discrete element methods (DEM) and physical modeling. Results show that the DEM can simulate all failure modes of rock slopes with different joint configurations. The stress in each rock block is not homogeneous and blocks rotate in failure development. Failure modes depend on the configuration of joints. Toppling failure is observed for the slope with straight joints and sliding failure is observed for the slope with staged joints. The DEM results are also compared with those of limit equilibrium method (LEM). Without considering the joints in rock masses, the LEM predicts much higher factor of safety than physical modeling and DEM. The failure mode and factor of safety predicted by the DEM are in good agreement with laboratory tests for any jointed rock slope.
Guérin, Bastein; Fakhri, Georges El
2008-01-01
We have developed and validated a realistic simulation of random coincidences, pixelated block detectors, light sharing among crystal elements and dead-time in 2D and 3D positron emission tomography (PET) imaging based on the SimSET Monte Carlo simulation software. Our simulation was validated by comparison to a Monte Carlo transport code widely used for PET modeling, GATE, and to measurements made on a PET scanner.
Modelling radiation exposure in homes from siporex blocks by using exhalation rates of radon
Nikolić Mladen D.
2015-01-01
Full Text Available Building materials are the second major source of indoor radon, after soil. The contribution of building materials to indoor radon amount depends upon the radium content and exhalation rates, which can be used as a primary index for radon levels in the dwellings. This paper presents the results of using the experimentally determined exhalation rates of siporex blocks and concrete plates, to assess the radiation exposure in dwellings built of siporex blocks. The annual doses in rooms have been estimated depending on the established modes of ventilation. Realistic scenario was created to predict an annual effective dose for an old person, a housewife, a student, and an employed tenant, who live in the same apartment, spending different periods of time in it. The results indicate the crucial importance of good ventilation of the living space.
A Modified Heuristic-Block Protocol Model for Privacy and Concurrency in Cloud
Akhilesh Kumar Bhardwaj
2015-09-01
Full Text Available With boost in the figure of cloud users and the magnitude of sensitive data on cloud, shielding of cloud has become more important. Competent methods are consistently desirable to ensure the information privacy and load management of outsource data on un-trusted cloud servers. The base of our proposed idea is the chronological display of metaheuristic firefly algorithm and blocks based Merkle hash tree protocol. This pool of combination significantly reduces the communication delay and I/O costs. The projected scheme in addition considers the dynamic data operations at block level while maintaining the equivalent security assurance. Our method makes use of third party auditor to periodically verify the data stored at cloud provider side. Our elucidation removes the burden of verification from the user side and alleviates both the user’s and storage service’s fear about data outburst and data corruptions.
Conformal blocks in Virasoro and W theories: Duality and the Calogero-Sutherland model
Estienne, Benoit, E-mail: b.d.a.estienne@uva.nl [Institute for Theoretical Physics, Universiteit van Amsterdam, Valckenierstraat 65, 1018 XE Amsterdam (Netherlands); Department of Physics, Princeton University, Princeton, NJ 08544 (United States); Pasquier, Vincent, E-mail: vincent.pasquier@cea.fr [Institut de Physique Theorique, DSM, CEA, URA2306 CNRS, Saclay, F-91191 Gif-sur-Yvette (France); Santachiara, Raoul, E-mail: raoul.santachiara@lptms.u-psud.fr [Laboratoire J.V. Poncelet, UMI 2615, Moscow (Russian Federation); LPTMS, CNRS, UMR 8626, Universite Paris-Sud, Batiment 100, 91405 Orsay (France); Serban, Didina, E-mail: didina.serban@cea.fr [Institut de Physique Theorique, DSM, CEA, URA2306 CNRS, Saclay, F-91191 Gif-sur-Yvette (France)
2012-07-21
We study the properties of the conformal blocks of the conformal field theories with Virasoro or W-extended symmetry. When the conformal blocks contain only second-order degenerate fields, the conformal blocks obey second order differential equations and they can be interpreted as ground-state wave functions of a trigonometric Calogero-Sutherland Hamiltonian with non-trivial braiding properties. A generalized duality property relates the two types of second order degenerate fields. By studying this duality we found that the excited states of the Calogero-Sutherland Hamiltonian are characterized by two partitions, or in the case of WA{sub k-1} theories by k partitions. By extending the conformal field theories under consideration by a u(1) field, we find that we can put in correspondence the states in the Hilbert state of the extended CFT with the excited non-polynomial eigenstates of the Calogero-Sutherland Hamiltonian. When the action of the Calogero-Sutherland integrals of motion is translated on the Hilbert space, they become identical to the integrals of motion recently discovered by Alba, Fateev, Litvinov and Tarnopolsky in Liouville theory in the context of the AGT conjecture. Upon bosonization, these integrals of motion can be expressed as a sum of two, or in general k, bosonic Calogero-Sutherland Hamiltonian coupled by an interaction term with a triangular structure. For special values of the coupling constant, the conformal blocks can be expressed in terms of Jack polynomials with pairing properties, and they give electron wave functions for special Fractional Quantum Hall states.
We consider a 1D spring-block model for earthquake dynamics under a modified frictional force, and examine the direction effects of a driving plate’s action on these dynamics. This force deals with a frictional parameter λ0 that takes into account the heterogeneity of the surface separating the two sides of the faults. We note that the amplitude of the motion of this block decays as the direction of the pulling force grows. Our investigations also show that the system undergoes a first order discontinuous transition from a stick-slip behavior to a creep motion as the friction parameter is varied. We establish that this phase transition is independent of the greatness of the driving plate’s velocity, but depends strongly on the direction of the pulling force. It also appears from our work that the critical values of the frictional velocity and the magnitude of the earthquake depend on λ0. (paper)
Morales Hurtado, M; de Vries, E G; Zeng, X; van der Heide, E
2016-09-01
Poly(vinyl) alcohol hydrogel (PVA) is a well-known polymer widely used in the medical field due to its biocompatibility properties and easy manufacturing. In this work, the tribo-mechanical properties of PVA-based blocks are studied to evaluate their suitability as a part of a structure simulating the length scale dependence of human skin. Thus, blocks of pure PVA and PVA mixed with Cellulose (PVA-Cel) were synthesised via freezing/thawing cycles and their mechanical properties were determined by Dynamic Mechanical Analysis (DMA) and creep tests. The dynamic tests addressed to elastic moduli between 38 and 50kPa for the PVA and PVA-Cel, respectively. The fitting of the creep compliance tests in the SLS model confirmed the viscoelastic behaviour of the samples with retardation times of 23 and 16 seconds for the PVA and PVA-Cel, respectively. Micro indentation tests were also achieved and the results indicated elastic moduli in the same range of the dynamic tests. Specifically, values between 45-55 and 56-81kPa were obtained for the PVA and PVA-Cel samples, respectively. The tribological results indicated values of 0.55 at low forces for the PVA decreasing to 0.13 at higher forces. The PVA-Cel blocks showed lower friction even at low forces with values between 0.2 and 0.07. The implementation of these building blocks in the design of a 2-layered skin model (2LSM) is also presented in this work. The 2LSM was stamped with four different textures and their surface properties were evaluated. The hydration of the 2LSM was also evaluated with a corneometer and the results indicated a gradient of hydration comparable to the human skin. PMID:27236420
Tibaldi and Molteni (1990, hereafter referred to as TM) had previously investigated operational blocking predictability by the ECMWF model and the possible relationships between model systematic error and blocking in the winter season of the Northern Hemisphere, using seven years of ECMWF operational archives of analyses and day 1 to 10 forecasts. They showed that fewer blocking episodes than in the real atmosphere were generally simulated by the model, and that this deficiency increased with increasing forecast time. As a consequence of this, a major contribution to the systematic error in the winter season was shown to derive from the inability of the model to properly forecast blocking. In this study, the analysis performed in TM for the first seven winter seasons of the ECMWF operational model is extended to the subsequent five winters, during which model development, reflecting both resolution increases and parametrisation modifications, continued unabated. In addition the objective blocking index developed by TM has been applied to the observed data to study the natural low frequency variability of blocking. The ability to simulate blocking of some climate models has also been tested
Pichai Aree
2005-07-01
Full Text Available The transfer-function block-diagram model of single-machine infinite-bus power system has been a popular analytical tool amongst power engineers for explaining and assessing synchronous generator dynamic behaviors. In previous studies, the effects of local load together with damper circuit on generator damping have not yet been addressed because neither of them was integrated into this model. Since the model only accounts for the generator main field circuit, it may not always yield a realistic damping assessment due to lack of damper circuit representation. This paper presents an extended transfer-function block-diagram model, which includes one of the q-axis damper circuits as well as local load. This allows a more realistic investigation of the local load effect on the generator damping. The extended model is applied to assess thegenerator dynamic performance. The results show that the damping power components mostly derived from the q-axis damper and the field circuits can be improved according to the local load. The frequency response method is employed to carry out the fundamental analysis.
De Zoysa, A. P.; Mendis, C.; Gamage-Mendis, A. C.; Weerasinghe, S; Herath, P. R.; Mendis, K N
1991-01-01
We have developed a multi-state mathematical model to describe the transmission of Plasmodium vivax malaria; the model accommodates variable transmission-blocking/enhancing immunity during the course of a blood infection, a short memory for boosting immunity, and relapses. Using the model, we simulated the incidence of human malaria, sporozoite rates in the vector population, and the level of transmission-blocking immunity for the infected population over a period of time. Field data from an ...
Parallel implementation of the time-evolving block decimation algorithm for the Bose-Hubbard model
Urbanek, Miroslav; Soldán, Pavel
2016-02-01
A system of ultracold atoms in an optical lattice represents a powerful experimental setup for testing the fundamentals of quantum mechanics. While its microscopic interaction mechanisms are well understood, the system behavior for a moderate number of particles is difficult to simulate due to a high dimension of its many-body space. This article presents TEBDOL, a parallel implementation of the time-evolving block decimation (TEBD) algorithm that can efficiently simulate time evolution of a one-dimensional chain of atoms in optical lattices. We investigate the parallelization strategy and the strong and weak scaling with the number of processes.
Mavrouli, O.; Corominas, J.; Jaboyedoff, M.
2015-07-01
In this paper, two analytical procedures which are independent from the existence of empirical data are presented for the calculation of (1) the size distribution of potentially unstable rock masses that expresses the potential rockfall size distribution, including big volumes corresponding to potential rare events with low susceptibility of failure and (2) the in situ block distribution on the slope face. Two approaches are, respectively, used. The first one involves the detection of kinematically unstable surfaces on a digital elevation model (DEM) and on orthophotos and the calculation of the volumes resting on them. For the second one the in situ block volumes formed by the intersection of the existing discontinuity sets are calculated using a high-resolution DEM. The procedures are presented through an application example at the country of Andorra and in particular at the chute of Forat Negre. The results from the first procedure indicate that it is kinematically possible to have mobilized volumes of some thousands of cubic meters; however, these are considered rare events with low susceptibility of failure. The size distribution of potentially unstable rock masses for big volume events was well fitted by a power law with an exponent of -0.5. The in situ block distribution on the slope face from the second procedure, assuming three types of intersection between the joints of the existing discontinuity sets and two extreme cases of discontinuity persistence, was also found to follow a power law, but with an exponent of -1.3. The comparison with the observed in the field block volume distribution on the slope face indicates that in reality discontinuities have a very high persistence and that considering only their visible trace length overestimates volumes, which is conservative.
Mattioli, G. S.; Jansma, P. E.; Stafford-Glenn, M.; Calais, E.
2011-12-01
The presence of small tectonic blocks the Greater Antilles, for example the Puerto Rico-Virgin Islands block (PRVI), which may be translating, rotating, and possibly internally deforming, has been proposed and some cases well-documented by several workers. In addition, the existence of a Lesser Antilles forearc has been proposed based on interplate earthquake slip vectors (Lopez et al. 2006). Manaker et al. (2008) used sparse GPS and earthquake slip data from the northeastern Caribbean to construct a DEFNODE block and fault model to constrain interseismic fault coupling among the microplates in the northeastern Caribbean. They concluded that the Enriquillo fault in Haiti could produce a Mw7.2, if the entire accumulated elastic strain was released in one event. On January 12, 2010, the strain was released in a Mw7.0 earthquake that left Port-au-Prince in rubble. The interseismic GPS velocity field has been updated for Hispanolia (Calais et al, 2010); in addition, new data have been collected in the northern Lesser Antilles (NLA) in 2009 as well as throughout the PRVI block in 2007 and 2011, and the existing GPS time series updated and transformed into ITRF05 (IGS05). GPS data from the NLA are consistent with a NLA forearc sliver that moves differently from the Caribbean and North American plates as originally proposed by Lopez et al. (2006). The forearc does not, however, continue as single tectonic entity across the Anegada Passage as previously suggested. Here we report revised DEFNODE models using both the original geometry and constraints of Manaker et al. (2008) with an updated GPS data set as well as new models that explicitly include a forearc block. The models may be used to explicitly define the rotation parameters of the block as well as the coupling along block bounding faults. The original model geometry (without a forearc sliver) yields a higher reduced chi-squared (2.57 vs. 2.01), when additional the GPS velocities from NLA are used to condition the
Geometry modeling and multi-block grid generation for turbomachinery configurations
Shih, Ming H.; Soni, Bharat K.
1992-01-01
An interactive 3D grid generation code, Turbomachinery Interactive Grid genERation (TIGER), was developed for general turbomachinery configurations. TIGER features the automatic generation of multi-block structured grids around multiple blade rows for either internal, external, or internal-external turbomachinery flow fields. Utilization of the Bezier's curves achieves a smooth grid and better orthogonality. TIGER generates the algebraic grid automatically based on geometric information provided by its built-in pseudo-AI algorithm. However, due to the large variation of turbomachinery configurations, this initial grid may not always be as good as desired. TIGER therefore provides graphical user interactions during the process which allow the user to design, modify, as well as manipulate the grid, including the capability of elliptic surface grid generation.
The principles of organization of connection between the attachments prepared in Access and AutoCAD are developed,and a technology of transfer from one application into another with displaying of delivered information is realized.Information models of Reactor Department Auxiliary Systems (RDAS) block premises from axes 25 to 51,and from rows 'U' to 'Yu', deaerator stack from axes 34 to 68,and from row 'B' to 'D', and turbine hall from axes 34 to 68 and from row 'A' to 'B',are created.The possibility is shown of using integrated information model to develop and visualize by means of computer animation the access routes in 'Ukryttia' object premises,to integrate raster image of structure and vector computer model of Object
Muhammad Shahzad Iqbal
2010-11-01
Full Text Available The current research highlights the trade among under the regime of South Asian Free Trade Agreements specially focus on trade with India. The Regional Block trade has given importance to the host as well receiving countries. Data were collected from various secondary sources and analysis by using Computable General Equilibrium model by using GEM pack. The regional trade among the Block countries are given absolutely and comparative advantage among various countries in the Blocks. The recent trade development shows positive results among the member countries specially in the context of free trade among South Asian Countries. ASEAN, NAFTA, MESUER trade gaining importance in the world and regional block trade has effect on the economies of the country. It was revealed that block trade has positive impact not only the countries economy but also welfare of the importing and host countries among the regional bloack.
Quistberg, D Alex; Howard, Eric J; Ebel, Beth E; Moudon, Anne V; Saelens, Brian E; Hurvitz, Philip M; Curtin, James E; Rivara, Frederick P
2015-11-01
Walking is a popular form of physical activity associated with clear health benefits. Promoting safe walking for pedestrians requires evaluating the risk of pedestrian-motor vehicle collisions at specific roadway locations in order to identify where road improvements and other interventions may be needed. The objective of this analysis was to estimate the risk of pedestrian collisions at intersections and mid-blocks in Seattle, WA. The study used 2007-2013 pedestrian-motor vehicle collision data from police reports and detailed characteristics of the microenvironment and macroenvironment at intersection and mid-block locations. The primary outcome was the number of pedestrian-motor vehicle collisions over time at each location (incident rate ratio [IRR] and 95% confidence interval [95% CI]). Multilevel mixed effects Poisson models accounted for correlation within and between locations and census blocks over time. Analysis accounted for pedestrian and vehicle activity (e.g., residential density and road classification). In the final multivariable model, intersections with 4 segments or 5 or more segments had higher pedestrian collision rates compared to mid-blocks. Non-residential roads had significantly higher rates than residential roads, with principal arterials having the highest collision rate. The pedestrian collision rate was higher by 9% per 10 feet of street width. Locations with traffic signals had twice the collision rate of locations without a signal and those with marked crosswalks also had a higher rate. Locations with a marked crosswalk also had higher risk of collision. Locations with a one-way road or those with signs encouraging motorists to cede the right-of-way to pedestrians had fewer pedestrian collisions. Collision rates were higher in locations that encourage greater pedestrian activity (more bus use, more fast food restaurants, higher employment, residential, and population densities). Locations with higher intersection density had a lower
Tidwell, V.C. [Sandia National Labs., Albuquerque, NM (United States); Wilson, J.L. [New Mexico Tech, Socorro, NM (United States)
1997-07-01
A specially designed minipermeameter test system, termed the Multisupport Permeameter (MSP), has been developed for direct physical investigation of permeability upscaling. The unique feature of this instrument is its ability to acquire permeability data at multiple sample supports subject to consistent boundary conditions and flow geometries. This device has been employed to physically investigate the permeability upscaling characteristics of a block of Berea Sandstone. Results reveal a number of consistent and distinct trends relating key summary statistics to changes in sample support. Comparisons are drawn between trends in the sample mean measured on the Berea Sandstone and that predicted by three theoretical upscaling models representing three common but different approaches to modeling permeability upscaling.
Dou Jianhong; Xia Ling; Zhang Yu; Shou Guofa [Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027 (China); Wei Qing; Liu Feng; Crozier, Stuart [School of Information Technology and Electrical Engineering, University of Queensland, St Lucia, Brisbane, Queensland 4072 (Australia)], E-mail: xialing@zju.edu.cn
2009-01-21
Asynchronous electrical activation, induced by bundle branch block (BBB), can cause reduced ventricular function. However, the effects of BBB on the mechanical function of heart are difficult to assess experimentally. Many heart models have been developed to investigate cardiac properties during BBB but have mainly focused on the electrophysiological properties. To date, the mechanical function of BBB has not been well investigated. Based on a three-dimensional electromechanical canine heart model, the mechanical properties of complete left and right bundle branch block (LBBB and RBBB) were simulated. The anatomical model as well as the fiber orientations of a dog heart was reconstructed from magnetic resonance imaging (MRI) and diffusion tensor MRI (DT-MRI). Using the solutions of reaction-diffusion equations and with a strategy of parallel computation, the asynchronous excitation propagation and intraventricular conduction in BBB was simulated. The mechanics of myocardial tissues were computed with time-, sarcomere length-dependent uniaxial active stress initiated at the time of depolarization. The quantification of mechanical intra- and interventricular asynchrony of BBB was then investigated using the finite-element method with an eight-node isoparametric element. The simulation results show that (1) there exists inter- and intraventricular systolic dyssynchrony during BBB; (2) RBBB may have more mechanical synchrony and better systolic function of the left ventricle (LV) than LBBB; (3) the ventricles always move toward the early-activated ventricle; and (4) the septum experiences higher stress than left and right ventricular free walls in BBB. The simulation results validate clinical and experimental recordings of heart deformation and provide regional quantitative estimates of ventricular wall strain and stress. The present work suggests that an electromechanical heart model, incorporating real geometry and fiber orientations, may be helpful for better
Asynchronous electrical activation, induced by bundle branch block (BBB), can cause reduced ventricular function. However, the effects of BBB on the mechanical function of heart are difficult to assess experimentally. Many heart models have been developed to investigate cardiac properties during BBB but have mainly focused on the electrophysiological properties. To date, the mechanical function of BBB has not been well investigated. Based on a three-dimensional electromechanical canine heart model, the mechanical properties of complete left and right bundle branch block (LBBB and RBBB) were simulated. The anatomical model as well as the fiber orientations of a dog heart was reconstructed from magnetic resonance imaging (MRI) and diffusion tensor MRI (DT-MRI). Using the solutions of reaction-diffusion equations and with a strategy of parallel computation, the asynchronous excitation propagation and intraventricular conduction in BBB was simulated. The mechanics of myocardial tissues were computed with time-, sarcomere length-dependent uniaxial active stress initiated at the time of depolarization. The quantification of mechanical intra- and interventricular asynchrony of BBB was then investigated using the finite-element method with an eight-node isoparametric element. The simulation results show that (1) there exists inter- and intraventricular systolic dyssynchrony during BBB; (2) RBBB may have more mechanical synchrony and better systolic function of the left ventricle (LV) than LBBB; (3) the ventricles always move toward the early-activated ventricle; and (4) the septum experiences higher stress than left and right ventricular free walls in BBB. The simulation results validate clinical and experimental recordings of heart deformation and provide regional quantitative estimates of ventricular wall strain and stress. The present work suggests that an electromechanical heart model, incorporating real geometry and fiber orientations, may be helpful for better
Wagner, M.
2010-10-01
The inherent variability of the solar resource presents a unique challenge for CSP systems. Incident solar irradiation can fluctuate widely over a short time scale, but plant performance must be assessed for long time periods. As a result, annual simulations with hourly (or sub-hourly) timesteps are the norm in CSP analysis. A highly detailed power cycle model provides accuracy but tends to suffer from prohibitively long run-times; alternatively, simplified empirical models can run quickly but don?t always provide enough information, accuracy, or flexibility for the modeler. The ideal model for feasibility-level analysis incorporates both the detail and accuracy of a first-principle model with the low computational load of a regression model. The work presented in this paper proposes a methodology for organizing and extracting information from the performance output of a detailed model, then using it to develop a flexible reduced-order regression model in a systematic and structured way. A similar but less generalized approach for characterizing power cycle performance and a reduced-order modeling methodology for CFD analysis of heat transfer from electronic devices have been presented. This paper builds on these publications and the non-dimensional approach originally described.
A multiscale modeling study of loss processes in block-copolymer-based solar cell nanodevices
Donets, Sergii; Pershin, Anton; Christlmaier, Martin J. A.; Baeurle, Stephan A.
2013-03-01
Flexible photovoltaic devices possess promising perspectives in opto-electronic technologies, where high mobility and/or large-scale applicability are important. However, their usefulness in such applications is currently still limited due to the low level of optimization of their performance and durability. For the improvement of these properties, a better understanding and control of small-scale annihilation phenomena involved in the photovoltaic process, such as exciton loss and charge carrier loss, is necessary, which typically implicates multiple length- and time-scales. Here, we study the causes for their occurrence on the example of nanostructured diblock- and triblock-copolymer systems by making use of a novel solar-cell simulation algorithm and explore new routes to optimize their photovoltaic properties. A particular focus is set on the investigation of exciton and charge carrier loss phenomena and their dependence on the inter-monomeric interaction strength, chain architecture, and external mechanical loading. Our simulation results reveal that in the regime from low up to intermediate χ-parameters an increasing number of continuous percolation paths is created. In this parameter range, the internal quantum efficiency (IQE) increases up to a maximum, characterized by a minimum in the number of charge losses due to charge recombination. In the regime of high χ-parameters both block-copolymer systems form nanostructures with a large number of bottlenecks and dead ends. These lead to a large number of charge losses due to charge recombination, charge trapping, and a deteriorated exciton dissociation, resulting in a significant drop in the IQE. Moreover, we find that the photovoltaic performance of the triblock-copolymer material decreases with increasing mechanical loading, caused by a growing number of charge losses due to charge recombination and charge accumulation. Finally, we demonstrate that the process of charge trapping in defects can be reversed
Hands-On Exercise in Environmental Structural Geology Using a Fracture Block Model.
Gates, Alexander E.
2001-01-01
Describes the use of a scale analog model of an actual fractured rock reservoir to replace paper copies of fracture maps in the structural geology curriculum. Discusses the merits of the model in enabling students to gain experience performing standard structural analyses. (DDR)
20-sim software for hierarchical bond-graph/block-diagram models
Broenink, Jan F.
1999-01-01
We discuss the modeling and simulation package 20-sim, a tool for modeling and simulation of dynamic behavior of engineering systems. Engineering systems as application domain means that we focus on systems that span multiple physical domains and the information domain. The 20-sim software is an int
Webb, Neil
2011-01-01
Filmed on the English south coast 'Ghost Block' depicts the uncanny and eerie atmosphere at the site of a WW2 coastal defence line. The concrete cubes were used as an anti-invasion blockade against potential landing forces. This protection line now slowly decaying and becoming enmeshed into the environment still acts as a defence to repel unwanted visitors. The area is a natural reserve to nesting birds that often lay eggs directly onto the beach surface. The blocks act as a final barrier ...
HADOOP+Big Data: Analytics Using Series Queue with Blocking Model
S. Koteeswaran
2014-07-01
Full Text Available Big data deals with large volumes of tons and tons of data. Since managing this much amount of data is not in the mere way for the traditional data mining techniques. Technology is in the world of pervasive environment i.e., technology follows up with its tremendous growth. Hence coordinating these amount of data in a linear way is mere little difficult, hence we proposed a new scheme in order to draw the data and data transformation in large data base. We extended our work in HADOOP (one of the big data managing tool. Our model is fully based on aggregation of data and data modelling. Our proposed model leads to high end data transformation for big data processing. We achieved our analytical result by applying our model with 2 HADOOP clusters, 4 nodes and with 25 jobs in MR functionality.
Kim, Kyu-Myong; Lau, K. M.; Wu, H. T.; Kim, Maeng-Ki; Cho, Chunho
2012-01-01
The Russia heat wave and wild fires of the summer of 2010 was the most extreme weather event in the history of the country. Studies show that the root cause of the 2010 Russia heat wave/wild fires was an atmospheric blocking event which started to develop at the end of June and peaked around late July and early August. Atmospheric blocking in the summer of 2010 was anomalous in terms of the size, duration, and the location, which shifted to the east from the normal location. This and other similar continental scale severe summertime heat waves and blocking events in recent years have raised the question of whether such events are occurring more frequently and with higher intensity in a warmer climate induced by greenhouse gases. We studied the spatial and temporal distributions of the occurrence and intensity of atmospheric blocking and associated heat waves for northern summer over Eurasia based on CMIPS model simulations. To examine the global warming induced change of atmospheric blocking and heat waves, experiments for a high emissions scenario (RCP8.S) and a medium mitigation scenario (RCP4.S) are compared to the 20th century simulations (historical). Most models simulate the mean distributions of blockings reasonably well, including major blocking centers over Eurasia, northern Pacific, and northern Atlantic. However, the models tend to underestimate the number of blockings compared to MERRA and NCEPIDOE reanalysis, especially in western Siberia. Models also reproduced associated heat waves in terms of the shifting in the probability distribution function of near surface temperature. Seven out of eight models used in this study show that the frequency of atmospheric blocking over the Europe will likely decrease in a warmer climate, but slightly increase over the western Siberia. This spatial pattern resembles the blocking in the summer of 2010, indicating the possibility of more frequent occurrences of heat waves in western Siberia. In this talk, we will also
Building Blocks for a Disequilibrium Model of a European Team Sports League
Andreff, Wladimir
2014-01-01
1 A standard equilibrium model of a team sports league was first elaborated on in the context of North American professional team sports leagues assuming that teams are profit-maximizing (El Hodiri & Quirk, 1971; Fort & Quirk, 1995). When economists adapted this model to European team sports leagues, instead of assuming a team's profit maximization they focused on a team's win-maximizing objective function. They did not care enough about how irrelevant some crucial hypotheses such as price fl...
... Drugs & Supplements Videos & Tools Español You Are Here: Home ... It numbs or causes a loss of feeling in the lower half your body. This lessens the pain of contractions during childbirth. An epidural block may also be used to ...
Cunha-Santos, Janete; Duarte-Neves, Joana; Carmona, Vitor; Guarente, Leonard; Pereira de Almeida, Luís; Cavadas, Cláudia
2016-01-01
Machado–Joseph disease (MJD) is a neurodegenerative disorder characterized by an abnormal expansion of the CAG triplet in the ATXN3 gene, translating into a polyglutamine tract within the ataxin-3 protein. The available treatments only ameliorate symptomatology and do not block disease progression. In this study we find that caloric restriction dramatically rescues the motor incoordination, imbalance and the associated neuropathology in transgenic MJD mice. We further show that caloric restriction rescues SIRT1 levels in transgenic MJD mice, whereas silencing SIRT1 is sufficient to prevent the beneficial effects on MJD pathology. In addition, the re-establishment of SIRT1 levels in MJD mouse model, through the gene delivery approach, significantly ameliorates neuropathology, reducing neuroinflammation and activating autophagy. Furthermore, the pharmacological activation of SIRT1 with resveratrol significantly reduces motor incoordination of MJD mice. The pharmacological SIRT1 activation could provide important benefits to treat MJD patients. PMID:27165717
Dhruv Sareen
Full Text Available Spinal muscular atrophy (SMA is a genetic disorder caused by a deletion of the survival motor neuron 1 gene leading to motor neuron loss, muscle atrophy, paralysis, and death. We show here that induced pluripotent stem cell (iPSC lines generated from two Type I SMA subjects-one produced with lentiviral constructs and the second using a virus-free plasmid-based approach-recapitulate the disease phenotype and generate significantly fewer motor neurons at later developmental time periods in culture compared to two separate control subject iPSC lines. During motor neuron development, both SMA lines showed an increase in Fas ligand-mediated apoptosis and increased caspase-8 and-3 activation. Importantly, this could be mitigated by addition of either a Fas blocking antibody or a caspase-3 inhibitor. Together, these data further validate this human stem cell model of SMA, suggesting that specific inhibitors of apoptotic pathways may be beneficial for patients.
Measurement and Modeling of Blocking Contacts for Cadmium Telluride Gamma Ray Detectors
Beck, Patrick R. [California Polytechnic State Univ. (CalPoly), San Luis Obispo, CA (United States)
2010-01-07
Gamma ray detectors are important in national security applications, medicine, and astronomy. Semiconductor materials with high density and atomic number, such as Cadmium Telluride (CdTe), offer a small device footprint, but their performance is limited by noise at room temperature; however, improved device design can decrease detector noise by reducing leakage current. This thesis characterizes and models two unique Schottky devices: one with an argon ion sputter etch before Schottky contact deposition and one without. Analysis of current versus voltage characteristics shows that thermionic emission alone does not describe these devices. This analysis points to reverse bias generation current or leakage through an inhomogeneous barrier. Modeling the devices in reverse bias with thermionic field emission and a leaky Schottky barrier yields good agreement with measurements. Also numerical modeling with a finite-element physics-based simulator suggests that reverse bias current is a combination of thermionic emission and generation. This thesis proposes further experiments to determine the correct model for reverse bias conduction. Understanding conduction mechanisms in these devices will help develop more reproducible contacts, reduce leakage current, and ultimately improve detector performance.
Optimal three-field block-preconditioners for models of coupled magma/mantle dynamics
Rhebergen, Sander; Wathen, Andrew J; Katz, Richard F
2014-01-01
For a prescribed porosity, the coupled magma/mantle flow equations can be formulated as a two field system of equations with velocity and pressure unknowns. Previous work has shown that while optimal preconditioners for the two field formulation can be constructed, the construction of preconditioners that are uniform with respect to model parameters is difficult. This limits the applicability of two field preconditioners in certain regimes of practical interest. We address this issue by reformulating the governing equations as a three field problem, which removes a term that was problematic in the two field formulation in favour of an additional equation for a pressure-like field. For the three-field problem, we develop and analyse new preconditioners and we show numerically that the new three-field preconditioners are optimal in terms of problem size and less sensitive to model parameters compared to the two-field preconditioner. This extends the applicability of optimal preconditioners for coupled mantle/ma...
Huang, Xiaoqin; Gu, Howard H.; Zhan, Chang-Guo
2009-01-01
Molecular modeling and dynamics simulations have been performed to study how cocaine inhibits dopamine transporter (DAT) for the transport of dopamine. The computationally determined DAT-ligand binding mode is totally different from previously proposed overlap binding mode in which cocaine- and dopamine-binding sites are the same (Beuming, T. et al. Nature Neurosci. 2008, 11, 780–789). The new cocaine-binding site does not overlap with, but close to, the dopamine-binding site. Analysis of all...
Bramwell Osula; Eddie C. W. Ng
2014-01-01
In this paper, the authors propose extending the construct of non-profit leadership to accommodate collaborative and transformational themes. The suggestion is that the resultant broader definition accords with the modern context within which non-profits now operate and feeds into a more resilient model of non-profit leadership. The paper begins with a review of emergent trends in leadership theory and the changing context of the non-profit sector. The argument is made that the extraordinary...
Accuracy of finite-element models for the stress analysis of multiple-holed moderator blocks
Two steps have been taken to quantify and improve the accuracy in the analysis. First, the limitations of various approximation techniques have been studied with the aid of smaller benchmark problems containing fewer holes. Second, a new family of computer programs has been developed for handling such large problems. This paper describes the accuracy studies and the benchmark problems. A review is given of some proposed modeling techniques including local mesh refinement, homogenization, a special-purpose finite element, and substructuring. Some limitations of these approaches are discussed. The new finite element programs and the features that contribute to their efficiency are discussed. These include a standard architecture for out-of-core data processing and an equation solver that operates on a peripheral array processor. The central conclusions of the paper are: (1) modeling approximation methods such as local mesh refinement and homogenization tend to be unreliable, and they should be justified by a fine mesh benchmark analysis; and (2) finite element codes are now available that can achieve accurate solutions at a reasonable cost, and there is no longer a need to employ modeling approximations in the two-dimensional analysis of HTGR fuel elements. 10 figures
Classical Virasoro irregular conformal block
Rim, Chaiho
2015-01-01
Virasoro irregular conformal block with arbitrary rank is obtained for the classical limit or equivalently Nekrasov-Shatashvili limit using the beta-deformed irregular matrix model (Penner-type matrix model for the irregular conformal block). The same result is derived using the generalized Mathieu equation which is equivalent to the loop equation of the irregular matrix model.
Bramwell Osula
2014-04-01
Full Text Available In this paper, the authors propose extending the construct of non-profit leadership to accommodate collaborative and transformational themes. The suggestion is that the resultant broader definition accords with the modern context within which non-profits now operate and feeds into a more resilient model of non-profit leadership. The paper begins with a review of emergent trends in leadership theory and the changing context of the non-profit sector. The argument is made that the extraordinary challenges facing the sector signal the need for fresh new perspectives in leadership. The authors then proceed to examine the significance of a nascent non-profit culture point to a re-alignment of the sector that is informed by transformational principles and a values-orientation. The result is said to be a new model of non-profit and public sector leadership that raises important methodological questions which the authors maintain can inform future analyses of the structure, role, and responsibilities of non-profit leadership. Finally, a world of new possibilities is envisioned, one in which non-profit organizations are strategically repositioned to take advantage of a new values-based ethic that is rooted in principles of integrity, increased self-awareness, a collaborative agenda, intentionality, emphasis of followership, cultural competence, and orientation toward the future.
Over the last decade, Sm-Nd model age mapping has been successfully used for deciphering temporally distinct crustal domains in many complex Precambrian terrains. The Sm-Nd model ages combined with age data by other methods, such as U-Pb zircon, form a powerful approach for constraining timing of crust formation in Precambrian poly-metamorphic terrains. When used judiciously, the Sm-Nd model ages (generally depleted mantle ages, TDM), could relate to the time of extraction of magmatic protoliths from the upper mantle. A large database of new Sm-Nd and Rb-Sr isotopic analyses (86 samples) on Precambrian basement gneisses (mainly charnockite gneisses) along a wide corridor representing a N-S cross section across the Cauvery Shear Zone (CSZ), of the Southern Granulite Terrain (SGT), South India are considered here. Spatial distribution of the crust-formation ages is considered mainly in terms of: (1) deciphering temporally distinct crustal blocks across the CSZ and (2) the tectonic significance of the CSZ both in the regional and global (Gondwana) perspective
Guérin, Bastein; Fakhri, Georges El
2008-01-01
We have developed and validated a realistic simulation of random coincidences, pixelated block detectors, light sharing among crystal elements and dead-time in 2D and 3D positron emission tomography (PET) imaging based on the SimSET Monte Carlo simulation software. Our simulation was validated by comparison to a Monte Carlo transport code widely used for PET modeling, GATE, and to measurements made on a PET scanner. Methods We have modified the SimSET software to allow independent tracking of single photons in the object and septa while taking advantage of existing voxel based attenuation and activity distributions and validated importance sampling techniques implemented in SimSET. For each single photon interacting in the detector, the energy-weighted average of interaction points was computed, a blurring model applied to account for light sharing and the associated crystal identified. Detector dead-time was modeled in every block as a function of the local single rate using a variance reduction technique. Electronic dead-time was modeled for the whole scanner as a function of the prompt coincidences rate. Energy spectra predicted by our simulation were compared to GATE. NEMA NU-2 2001 performance tests were simulated with the new simulation as well as with SimSET and compared to measurements made on a Discovery ST (DST) camera. Results Errors in simulated spatial resolution (full width at half maximum, FWHM) were 5.5% (6.1%) in 2D (3D) with the new simulation, compared with 42.5% (38.2%) with SimSET. Simulated (measured) scatter fractions were 17.8% (21.3%) in 2D and 45.8% (45.2%) in 3D. Simulated and measured sensitivities agreed within 2.3 % in 2D and 3D for all planes and simulated and acquired count rate curves (including NEC) were within 12.7% in 2D in the [0: 80 kBq/cc] range and in 3D in the [0: 35 kBq/cc] range. The new simulation yielded significantly more realistic singles’ and coincidences’ spectra, spatial resolution, global sensitivity and lesion
Resistance to fire of walls constituted by hollow blocks: Experiments and thermal modeling
The thermo-mechanical behavior of masonry walls is investigated from both experimental and theoretical points of view. Fire tests have been performed in order to evaluate the thermo-mechanical resistance of masonry wall submitted to a vertical load (13 ton/m) and exposed to temperatures ranging from 20 to 1200 oC. As a result we measure the temperature evolution inside the wall and evaluate the vertical and lateral displacements of this wall during heating for a period of 6 h. These results are affected significantly by phase-change phenomena which appeared as a plateau around oC in temperature-time curves. A theoretical model was then developed to describe the experimental results taking in to account convection, conduction and radiation phenomena inside the wall. In addition, liquid water migration using an enthalpic method is considered
velocity and the slug predominant frequency were obtained from the void fraction signals. The waves were filmed using a digital video camera and the frame images were used to extract their amplitudes. Even though, for co-current flows, the formation of slugs has been explained in terms of the Kelvin-Helmholtz instability criterion, we did not observe that the slugging phenomena were triggered by this type of instability. Thus, the objective of this paper is to provide a model that explain the formation of slugs in a CCF. The model is based on the Boussinesq nonlinear system of equations that are discretized by using leap-frog scheme and solved numerically. The results have been used to obtain the slug frequency and propagation velocity. We have calculated the slug frequency from the lag time between the instant a train of solitons are formed in the horizontal leg and the instant that two trains of solitons collide with each other to form a slug. The slug propagation velocity has been estimated by using a control volume approach, the average horizontal velocity given by the model and the velocity of gravitational waves. The predictions of the model were compared with the slug data; in general, a good agreement between the predictions and the data was found. (authors)
Community Detection Algorithm Combining Stochastic Block Model and Attribute Data Clustering
Kataoka, Shun; Yasuda, Muneki; Tanaka, Kazuyuki
2016-01-01
We propose a new algorithm to detect the community structure in a network that utilizes both the network structure and vertex attribute data. Suppose we have the network structure together with the vertex attribute data, that is, the information assigned to each vertex associated with the community to which it belongs. The problem addressed this paper is the detection of the community structure from the information of both the network structure and the vertex attribute data. Our approach is based on the Bayesian approach that models the posterior probability distribution of the community labels. The detection of the community structure in our method is achieved by using belief propagation and an EM algorithm. We numerically verified the performance of our method using computer-generated networks and real-world networks.
Mutant bacterial sodium channels as models for local anesthetic block of eukaryotic proteins.
Smith, Natalie E; Corry, Ben
2016-05-01
Voltage gated sodium channels are the target of a range of local anesthetic, anti-epileptic and anti-arrhythmic compounds. But, gaining a molecular level understanding of their mode of action is difficult as we only have atomic resolution structures of bacterial sodium channels not their eukaryotic counterparts. In this study we used molecular dynamics simulations to demonstrate that the binding sites of both the local anesthetic benzocaine and the anti-epileptic phenytoin to the bacterial sodium channel NavAb can be altered significantly by the introduction of point mutations. Free energy techniques were applied to show that increased aromaticity in the pore of the channel, used to emulate the aromatic residues observed in eukaryotic Nav1.2, led to changes in the location of binding and dissociation constants of each drug relative to wild type NavAb. Further, binding locations and dissociation constants obtained for both benzocaine (660 μM) and phenytoin (1 μ M) in the mutant channels were within the range expected from experimental values obtained from drug binding to eukaryotic sodium channels, indicating that these mutant NavAb may be a better model for drug binding to eukaryotic channels than the wild type. PMID:26852716
Jensen, Grethe Vestergaard; Shi, Qing; Deen, G. Roshan;
2012-01-01
Structures of poly(ethylene propylene)–poly(ethylene oxide) (PEP–PEO) block copolymer micelles were determined from small-angle X-ray scattering and static light scattering and compared to predictions from a thermodynamic model. Both the corona block length and the solvent water–ethanol ratio were...... water (except for the highest PEO molar mass), the micelles were cylindrical; for other conditions they were spherical. The structural parameters can be reasonably well described by the thermodynamic model by Zhulina et al. [Macromolecules2005, 38 (12), 5330–5351]; however, they have a stronger...
Xu, Hua-Neng; Liu, Huan-Huan; Zhang, Lianfu
2015-08-25
The stability of cyclodextrin (CD)-based emulsions is attributed to the formation of a solid film of oil-CD complexes at the oil/water interface. However, competitive interactions between CDs and other components at the interface still need to be understood. Here we develop two different routes that allow the incorporation of a model protein (sodium caseinate, SC) into emulsions based on β-CD. One route is the components adsorbed simultaneously from a mixed solution to the oil/water interface (route I), and the other is SC was added to a previously established CD-stabilized interface (route II). The adsorption mechanism of β-CD modified by SC at the oil/water interface is investigated by rheological and optical methods. Strong sensitivity of the rheological behavior to the routes is indicated by both steady-state and small-deformation oscillatory experiments. Possible β-CD/SC interaction models at the interface are proposed. In route I, the protein, due to its higher affinity for the interface, adsorbs strongly at the interface with blocking of the adsorption of β-CD and formation of oil-CD complexes. In route II, the protein penetrates and blends into the preadsorbed layer of oil-CD complexes already formed at the interface. The revelation of interfacial assembly is expected to help better understand CD-based emulsions in natural systems and improve their designs in engineering applications. PMID:26228663
Sadykov, Raman; Kiponievich Ogay, Evgeniy; Royer, Jean-Jacques; Zhapbasbayev, Uzak; Panfilova, Irina
2015-04-01
Coal Bed Methane (CBM) is gas stored in coal layers. It can be extracted from wells after hydraulic fracturing and/or solvent injection, and secondary recovery techniques such as CO2 injection. Karaganda Basin is a very favorable candidate region to develop CBM production for the following reasons: (i) Huge gas potential; (ii) Available technologies for extracting and commercializing the gas produced by CBM methods; (iii) Experience in degassing during underground mining operations for safety reasons; (iv) Local needs in energy for producing electricity for the industrial and domestic market. The objectives of this work are to model the Taldykuduk block coal layers and their properties focusing on Coal Bed Methane production. It is motivated by the availability of large coal bed methane resources in Karaganda coal basin which includes 4 300 Bm3 equivalent 2 billion tons of coal (B = billion = 109) with gas content 15-25 m3/t of coal (for comparison San Juan basin (USA) has matrix (m) and the fracture (f) for which the initial and boundary conditions are different. The resulting comprehensive 3D models had helped in better understanding the tectonic structures of the region, especially the relationships between the fault systems.
Kudryavtsev, Andrey V.; Laurent, Guillaume J.; Clévy, Cédric; Tamadazte, Brahim; Lutz, Philippe
2015-10-01
Microassembly is an innovative alternative to the microfabrication process of MOEMS, which is quite complex. It usually implies the use of microrobots controlled by an operator. The reliability of this approach has been already confirmed for micro-optical technologies. However, the characterization of assemblies has shown that the operator is the main source of inaccuracies in the teleoperated microassembly. Therefore, there is great interest in automating the microassembly process. One of the constraints of automation in microscale is the lack of high precision sensors capable to provide the full information about the object position. Thus, the usage of visual-based feedback represents a very promising approach allowing to automate the microassembly process. The purpose of this article is to characterize the techniques of object position estimation based on the visual data, i.e., visual tracking techniques from the ViSP library. These algorithms enables a 3-D object pose using a single view of the scene and the CAD model of the object. The performance of three main types of model-based trackers is analyzed and quantified: edge-based, texture-based and hybrid tracker. The problems of visual tracking in microscale are discussed. The control of the micromanipulation station used in the framework of our project is performed using a new Simulink block set. Experimental results are shown and demonstrate the possibility to obtain the repeatability below 1 µm.
Yang, Xiao-Qiang; Li, Zi-Long; Yu, Sheng-Qiang
2016-08-01
Charnockites in the Datian region of the northeastern Cathaysia Block, South China have an assemblage of garnet, clinopyroxene, orthopyroxene, plagioclase, anti-perthite, K-feldspar, biotite, quartz and ilmenite. Phase equilibrium modeling indicates that the Datian charnockite was formed at T = 845-855 °C and P = 8.2-8.4 kbar with corresponding water activity lower than 0.50. Fluid inclusions in the Datian charnockite are dominated by N2 and CO2 with minor CH4. The fluids homogenized to liquid at -153.0 to -138.8 °C and 18.3-21.6 °C, respectively, showing a low-density nature. The low-density fluids could be attributed to selective leakage of water due to the affinity of water to melt and decompression-dominated retrograde process. Combined with previous studies, a two-stage formation model is proposed to interpret the petrogenesis of the Datian charnockite, viz emplaced at the Paleoproterozoic and underwent the granulite-facies metamorphism during the Phanerozoic tectonic event.
Borisov, O.V.; Zhulina, E.B.; Leermakers, F.A.M.; Muller, A.H.E.
2011-01-01
We present an overview of statistical thermodynamic theories that describe the self-assembly of amphiphilic ionic/hydrophobic diblock copolymers in dilute solution. Block copolymers with both strongly and weakly dissociating (pH-sensitive) ionic blocks are considered. We focus mostly on structural a
Yuan Zhang
2016-01-01
Full Text Available A type of concrete hollow block with typical structure and a common phase change material (PCM were adopted. The PCM was filled into the hollow blocks by which the multiform composite PCM hollow blocks were made. The temperature-changing hot chamber method was used to test the thermal performance of block walls. The enthalpy method and the effective heat capacity method were used to calculate the heat transfer process. The results of the two methods can both reach the reasonable agreement with the experimental data. The unsteady-state thermal performance of the PCM hollow block walls is markedly higher than that of the wall without PCM. Furthermore, if the temperature of the PCM in the wall does not exceed its phase transition temperature range, the PCM wall can reach high thermal performance.
Kaylani, Samer Z. [Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 414, Birmingham, AL 35233 (United States); Xu, Jianmin; Srivastava, Ritesh K. [Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294-0019 (United States); Kopelovich, Levy [Division of Cancer Prevention, National Cancer Institute, Bethesda (United States); Pressey, Joseph G. [Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 414, Birmingham, AL 35233 (United States); Athar, Mohammad, E-mail: mathar@uab.edu [Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294-0019 (United States)
2013-06-14
Graphical abstract: Intervention of poorly differentiated RMS by rapamycin: In poorly differentiated RMS, rapamycin blocks mTOR and Hh signaling pathways concomitantly. This leads to dampening in cell cycle regulation and induction of apoptosis. This study provides a rationale for the therapeutic intervention of poorly differentiated RMS by treating patients with rapamycin alone or in combination with other chemotherapeutic agents. -- Highlights: •Rapamycin abrogates RMS tumor growth by modulating proliferation and apoptosis. •Co-targeting mTOR/Hh pathways underlie the molecular basis of effectiveness. •Reduction in mTOR/Hh pathways diminish EMT leading to reduced invasiveness. -- Abstract: Rhabdomyosarcomas (RMS) represent the most common childhood soft-tissue sarcoma. Over the past few decades outcomes for low and intermediate risk RMS patients have slowly improved while patients with metastatic or relapsed RMS still face a grim prognosis. New chemotherapeutic agents or combinations of chemotherapies have largely failed to improve the outcome. Based on the identification of novel molecular targets, potential therapeutic approaches in RMS may offer a decreased reliance on conventional chemotherapy. Thus, identification of effective therapeutic agents that specifically target relevant pathways may be particularly beneficial for patients with metastatic and refractory RMS. The PI3K/AKT/mTOR pathway has been found to be a potentially attractive target in RMS therapy. In this study, we provide evidence that rapamycin (sirolimus) abrogates growth of RMS development in a RMS xenograft mouse model. As compared to a vehicle-treated control group, more than 95% inhibition in tumor growth was observed in mice receiving parenteral administration of rapamycin. The residual tumors in rapamycin-treated group showed significant reduction in the expression of biomarkers indicative of proliferation and tumor invasiveness. These tumors also showed enhanced apoptosis
Hein, James R.; Conrad, Tracey A.; Dunham, Rachel E.
2009-01-01
Regulations are being developed through the International Seabed Authority (ISBA) for the exploration and mining of cobalt-rich ferromanganese crusts. This paper lays out geologic and geomorphologic criteria that can be used to determine the size and number of exploration and mine-site blocks that will be the focus of much discussion within the ISBA Council deliberations. The surface areas of 155 volcanic edifices in the central equatorial Pacific were measured and used to develop a mine-site model. The mine-site model considers areas above 2,500 m water depth as permissive, and narrows the general area available for exploration and mining to 20% of that permissive area. It is calculated that about eighteen 100 km2 explora-tion blocks, each composed of five 20km2 contiguous sub-blocks, would be adequate to identify a 260 km2 20-year-mine site; the mine site would be composed of thirteen of the 20km2 sub-blocks. In this hypothetical example, the 260 km2 mine site would be spread over four volcanic edifices and comprise 3.7% of the permissive area of the four edifices and 0.01% of the total area of those four edifices. The eighteen 100km2 exploration blocks would be selected from a limited geographic area. That confinement area is defined as having a long dimension of not more than 1,000 km and an area of not more than 300,000 km2.
Thermal insulation was the cause of the blockages that shut down five BWRs in Sweden. The main culprit was mineral wool installed when the plants started up. Physical degradation of the wool over the lifetime of the plant meant it could easily be washed out of place during a loss of coolant accident and could quickly block strainers in the emergency core cooling systems. The five BWRs are almost all back on line, equipped with larger strainers and faster backwashing capability. But the incident prompted more detailed investigation into how materials in the containment would behave during an accident. One material that caused particular concern is Caposil, a material often used to insulate the reactor vessel. Composed of natural calcium, aluminium silicates and cellulose fibres, in the event of a LOCA Caposil becomes particularly hazardous. Under high pressure, or when brought into contact with high pressure water and steam, Caposil fragments into 1 cm clumps, free fibres, and ''fines''. It is these fines which cause major problems and can block a strainer extremely quickly. The successful testing of a high performance water filter which can handle Caposil is described. (4 figures) (Author)
Katz, Jennifer
2015-01-01
Fifty-eight teachers of grades 1-12 in 10 schools located in two rural and three urban school divisions in Manitoba were involved in a study implementing the Three Block Model of Universal Design for Learning and exploring its outcomes for teachers and students. This article reports teachers' perceptions related to the outcomes of the…
Khaira, Gurdaman Singh
Rapid progress in the semi-conductor industry has pushed for smaller feature sizes on integrated electronic circuits. Current photo-lithographic techniques for nanofabrication have reached their technical limit and are problematic when printing features small enough to meet future industrial requirements. "Bottom-up'' techniques, such as the directed self-assembly (DSA) of block copolymers (BCP), are the primary contenders to compliment current "top-down'' photo-lithography ones. For industrial requirements, the defect density from DSA needs to be less than 1 defect per 10 cm by 10 cm. Knowledge of both material synthesis and the thermodynamics of the self-assembly process are required before optimal operating conditions can be found to produce results adequate for industry. The work present in this thesis is divided into three chapters, each discussing various aspects of DSA as studied via a molecular model that contains the essential physics of BCP self-assembly. Though there are various types of guiding fields that can be used to direct BCPs over large wafer areas with minimum defects, this study focuses only on chemically patterned substrates. The first chapter addresses optimal pattern design by describing a framework where molecular simulations of various complexities are coupled with an advanced optimization technique to find a pattern that directs a target morphology. It demonstrates the first ever study where BCP self-assembly on a patterned substrate is optimized using a three-dimensional description of the block-copolymers. For problems pertaining to DSA, the methodology is shown to converge much faster than the traditional random search approach. The second chapter discusses the metrology of BCP thin films using TEM tomography and X-ray scattering techniques, such as CDSAXS and GISAXS. X-ray scattering has the advantage of being able to quickly probe the average structure of BCP morphologies over large wafer areas; however, deducing the BCP morphology
De Zoysa, A P; Mendis, C; Gamage-Mendis, A C; Weerasinghe, S; Herath, P R; Mendis, K N
1991-01-01
We have developed a multi-state mathematical model to describe the transmission of Plasmodium vivax malaria; the model accommodates variable transmission-blocking/enhancing immunity during the course of a blood infection, a short memory for boosting immunity, and relapses. Using the model, we simulated the incidence of human malaria, sporozoite rates in the vector population, and the level of transmission-blocking immunity for the infected population over a period of time. Field data from an epidemiological study conducted in Kataragama in the south of Sri Lanka were used to test the results obtained. The incidence of malaria during the study period was simulated satisfactorily. The impact of naturally-acquired transmission-blocking immunity on malaria transmission under different vectorial capacities was also simulated. The results show that at low vectorial capacities, e.g., just above the threshold for transmission, the effect of transmission-blocking immunity is very significant; however, the effect is lower at higher vectorial capacities. PMID:1786621
Meigooni, Ali S; Dou, Kai; Meigooni, Navid J; Gnaster, Michael; Awan, Shahid; Dini, Sharifeh; Johnson, Ellis L
2006-09-01
Grid radiation therapy with megavoltage x-ray beam has been proven to be an effective technique for management of large, bulky malignant tumors. The clinical advantage of GRID therapy, combined with conventional radiation therapy, has been demonstrated using a prototype GRID block [Mohiuddin, Curtis, Grizos, and Komarnicky, Cancer 66, 114-118 (1990)]. Recently, a new GRID block design with improved dosimetric properties has become commercially available from Radiation Product Design, Inc. (Albertive, MN). This GRID collimator consists of an array of focused apertures in a cerrobend block arranged in a hexagonal pattern having a circular cross-section with a diameter and center-to-center spacing of 14.3 and 21.1 mm, respectively, in the plane of isocenter. In this project, dosimetric characteristics of the newly redesigned GRID block have been investigated for a Varian 21EX linear accelerator (Varian Associates, Palo Alto, CA). These determinations were performed using radiographic films, thermoluminescent dosimeters in Solid Water phantom materials, and an ionization chamber in water. The output factor, percentage depth dose, beam profiles, and isodose distributions of the GRID radiation as a function of field size and beam energy have been measured using both 6 and 18 MV x-ray beams. In addition, the therapeutic advantage obtained from this treatment modality with the new GRID block design for a high, single fraction of dose has been calculated using the linear quadratic model with alpha/beta ratios for typical tumor and normal cells. These biological characteristics of the new GRID block design will also be presented. PMID:17022209
Lin, W
2001-12-01
This report documents the Large-Block Test (LBT) conducted at Fran Ridge near Yucca Mountain, Nevada. The LBT was a thermal test conducted on an exposed block of middle non-lithophysal Topopah Spring tuff (Tptpmn) and was designed to assist in understanding the thermal-hydrological-mechanical-chemical (THMC) processes associated with heating and then cooling a partially saturated fractured rock mass. The LBT was unique in that it was a large (3 x 3 x 4.5 m) block with top and sides exposed. Because the block was exposed at the surface, boundary conditions on five of the six sides of the block were relatively well known and controlled, making this test both easier to model and easier to monitor. This report presents a detailed description of the test as well as analyses of the data and conclusions drawn from the test. The rock block that was tested during the LBT was exposed by excavation and removal of the surrounding rock. The block was characterized and instrumented, and the sides were sealed and insulated to inhibit moisture and heat loss. Temperature on the top of the block was also controlled. The block was heated for 13 months, during which time temperature, moisture distribution, and deformation were monitored. After the test was completed and the block cooled down, a series of boreholes were drilled, and one of the heater holes was over-cored to collect samples for post-test characterization of mineralogy and mechanical properties. Section 2 provides background on the test. Section 3 lists the test objectives and describes the block site, the site configuration, and measurements made during the test. Section 3 also presents a chronology of events associated with the LBT, characterization of the block, and the pre-heat analyses of the test. Section 4 describes the fracture network contained in the block. Section 5 describes the heating/cooling system used to control the temperature in the block and presents the thermal history of the block during the test
Radionuclides escaping from a repository in crystalline rock for spent nuclear fuel will migrate with the seeping water in the fissures. Most radionuclides will be retarded by sorption on the rock surfaces and by diffusion into the rock matrix. Available surface for sorption and residence time are two prime variables which influence the radionuclide movement. The water velocity may vary very much along a flow path especially if the flow path enters a strongly fissured zone (lineament). In this paper the radionuclides in a stream tube with an arbitrary velocity along the flow path have been investigated and a numerical scheme based on the integrated finite difference method - IFDM - is proposed for practical calculations. The transport mechanisms considered are advection and longitudinal dispersion and the retardation mechanisms used are instantaneous sorption in a portion of the rock (surface sorption) and diffusion into the rock matrix and sorption on the micropore surfaces. An attempt is also made to account for blocks of various sizes by the MINC approach (Multiple Interacting Continua). This method accounts for the large sorption surface but small volume of small blocks and small surface area but large volume of large blocks. Any block size distribution can be handled. (authors)
An, Ji-Yong; You, Zhu-Hong; Meng, Fan-Rong; Xu, Shu-Juan; Wang, Yin
2016-01-01
Protein-Protein Interactions (PPIs) play essential roles in most cellular processes. Knowledge of PPIs is becoming increasingly more important, which has prompted the development of technologies that are capable of discovering large-scale PPIs. Although many high-throughput biological technologies have been proposed to detect PPIs, there are unavoidable shortcomings, including cost, time intensity, and inherently high false positive and false negative rates. For the sake of these reasons, in silico methods are attracting much attention due to their good performances in predicting PPIs. In this paper, we propose a novel computational method known as RVM-AB that combines the Relevance Vector Machine (RVM) model and Average Blocks (AB) to predict PPIs from protein sequences. The main improvements are the results of representing protein sequences using the AB feature representation on a Position Specific Scoring Matrix (PSSM), reducing the influence of noise using a Principal Component Analysis (PCA), and using a Relevance Vector Machine (RVM) based classifier. We performed five-fold cross-validation experiments on yeast and Helicobacter pylori datasets, and achieved very high accuracies of 92.98% and 95.58% respectively, which is significantly better than previous works. In addition, we also obtained good prediction accuracies of 88.31%, 89.46%, 91.08%, 91.55%, and 94.81% on other five independent datasets C. elegans, M. musculus, H. sapiens, H. pylori, and E. coli for cross-species prediction. To further evaluate the proposed method, we compare it with the state-of-the-art support vector machine (SVM) classifier on the yeast dataset. The experimental results demonstrate that our RVM-AB method is obviously better than the SVM-based method. The promising experimental results show the efficiency and simplicity of the proposed method, which can be an automatic decision support tool. To facilitate extensive studies for future proteomics research, we developed a freely
Fai, S.; Rafeiro, J.
2014-05-01
In 2011, Public Works and Government Services Canada (PWGSC) embarked on a comprehensive rehabilitation of the historically significant West Block of Canada's Parliament Hill. With over 17 thousand square meters of floor space, the West Block is one of the largest projects of its kind in the world. As part of the rehabilitation, PWGSC is working with the Carleton Immersive Media Studio (CIMS) to develop a building information model (BIM) that can serve as maintenance and life-cycle management tool once construction is completed. The scale and complexity of the model have presented many challenges. One of these challenges is determining appropriate levels of detail (LoD). While still a matter of debate in the development of international BIM standards, LoD is further complicated in the context of heritage buildings because we must reconcile the LoD of the BIM with that used in the documentation process (terrestrial laser scan and photogrammetric survey data). In this paper, we will discuss our work to date on establishing appropriate LoD within the West Block BIM that will best serve the end use. To facilitate this, we have developed a single parametric model for gothic pointed arches that can be used for over seventy-five unique window types present in the West Block. Using the AEC (CAN) BIM as a reference, we have developed a workflow to test each of these window types at three distinct levels of detail. We have found that the parametric Gothic arch significantly reduces the amount of time necessary to develop scenarios to test appropriate LoD.
Vyazmensky, Alexander
2008-01-01
Recent years have seen a major increase of interest in the block cave mining method which is characterized by extraction of a massive volume of rock usually accompanied by the formation of a significant surface depression above and in the vicinity of the mining operation. The ability to predict surface subsidence is important for mine planning, operational hazard assessment and evaluation of environmental and socio-economic impacts. Owing to problems of scale and lack of access, the fundament...
Ultrasound guided supraclavicular block.
Hanumanthaiah, Deepak
2013-09-01
Ultrasound guided regional anaesthesia is becoming increasingly popular. The supraclavicular block has been transformed by ultrasound guidance into a potentially safe superficial block. We reviewed the techniques of performing supraclavicular block with special focus on ultrasound guidance.
Hammond, W. C.; Bormann, J.; Blewitt, G.; Kreemer, C.
2013-12-01
The Walker Lane in the western Great Basin of the western United States is an 800 km long and 100 km wide zone of active intracontinental transtension that absorbs ~10 mm/yr, about 20% of the Pacific/North America plate boundary relative motion. Lying west of the Sierra Nevada/Great Valley microplate (SNGV) and adjoining the Basin and Range Province to the east, deformation is predominantly shear strain overprinted with a minor component of extension. The Walker Lane responds with faulting, block rotations, structural step-overs, and has distinct and varying partitioned domains of shear and extension. Resolving these complex deformation patterns requires a long term observation strategy with a dense network of GPS stations (spacing ~20 km). The University of Nevada, Reno operates the 373 station Mobile Array of GPS for Nevada transtension (MAGNET) semi-continuous network that supplements coverage by other networks such as EarthScope's Plate Boundary Observatory, which alone has insufficient density to resolve the deformation patterns. Uniform processing of data from these GPS mega-networks provides a synoptic view and new insights into the kinematics and mechanics of Walker Lane tectonics. We present velocities for thousands of stations with time series between 3 to 17 years in duration aligned to our new GPS-based North America fixed reference frame NA12. The velocity field shows a rate budget across the southern Walker Lane of ~10 mm/yr, decreasing northward to ~7 mm/yr at the latitude of the Mohawk Valley and Pyramid Lake. We model the data with a new block model that estimates rotations and slip rates of known active faults between the Mojave Desert and northern Nevada and northeast California. The density of active faults in the region requires including a relatively large number of blocks in the model to accurately estimate deformation patterns. With 49 blocks, our the model captures structural detail not represented in previous province-scale models, and
Block model at the Hatay Triple junction in N-W Syria and S-E Turkey from GPS data inversion
Mahmoud, Yasser; Cakir, Ziyadin; Masson, Frédéric; Meghraoui, Mustapha
2013-04-01
The active deformation at the Hatay Triple junction (HTJ) in northwest Syria and southeast Turkey is represented by finite number of rotating elastic spherical blocks limited by faults. GPS derived horizontal velocities are inverted for the fault parameters and block angular velocities. We are using GPS vectors from our dense regional GPS network reinforced by other GPS solutions in the region.We test different tectonic configurations trying to minimize the data misfit of our model using a reduced chi-square statistic:χ_n^2=(∑r^2/s2 )/DOF.Residuals were calculated for different models in order to define the best fit to the known kinematic configuration of the region. A block model with the new Iskenderun and Amanous micro blocks and three major blocks of Arabia, Anatolia, and Sinai is essential to explain the GPS vectors. The estimated relative slip rates on faults are similar to other published estimations with some exceptions.The Karasu Fault shows a sinistral slip rate of 4.0 ± 1.0 mm/yr and a compressional behavior with a revers slip rate of 2.1-2.7 mm/yr, which contradicts with the extensional nature proposed by previous studies. The Dead Sea fault experiences a relative slip rate of ~3.5 ± 0.3 mm/yr along all its segments. We also define a new Euler pole for the relative angular velocity of Anatolia-Arabia Euler pole at (27.61oN, 45.127oE, 0.391± 0.056 o/Myr), and a Sinai-Arabia Euler pole at (31.012oN, 46.464oE, 0.202 ± 0.067 o/Myr).A 15 km of locking depth is estimated for the EAF, 4-5 km deeper than that of the Dead Sea Fault. The East Anatolian Fault is however partially locked down to the depths of 30 km with no significant extension or compression. In general, slip rates and kinematics of faults are consistent with the geological observations in the region.
Aróstegui, J.; Sangüesa, F. J.; Nieto, F.; Uriarte, J. A.
2006-01-01
Diagenesis in the Cretaceous and Tertiary sediments of the Alava Block (Basque-Cantabrian basin) has been studied using the clay mineralogy (X-ray diffraction) of cuttings from three representative wells of a N–S cross-section. More than 5500 m of various lithologies (marls, mudstones and sandstones) have been drilled in the northern part of the domain, and 2100 m in the southern zone. The illitization of smectite and the disappearance of kaolinite, due to diagenesis, are the most characteris...
Numerical simulation is an effective and economical tool for optimally designing laboratory experiments and deriving practical experimental conditions. We executed a detailed numerical simulation study to examine the active fracture concept (AFC, Liu et al., 1998) using a cubic meter-sized block model. The numerical simulations for this study were performed by applying various experimental conditions, including different bottom flow boundaries, varying injection rates, and different fracture-matrix interaction (by increasing absolute matrix permeability at the fracture matrix boundary) for a larger fracture interaction under transient or balanced-state flow regimes. Two conceptual block models were developed based on different numerical approaches: a two-dimensional discrete-fracture-network model (DFNM) and a one-dimensional dual continuum model (DCM). The DFNM was used as a surrogate for a natural block to produce synthetic breakthrough curves of water and tracer concentration under transient or balanced-state conditions. The DCM is the approach typically used for the Yucca Mountain Project because of its computational efficiency. The AFC was incorporated into the DCM to capture heterogeneous flow patterns that occur in unsaturated fractured rocks. The simulation results from the DCM were compared with the results from the DFNM to determine whether the DCM could predict the water flow and tracer transport observed in the DFNM at the scale of the experiment. It was found that implementing the AFC in the DCM improved the prediction of unsaturated flow and that the flow and transport experiments with low injection rates in the DFNM were compared better with the AFC implemented DCM at the meter scale. However, the estimated AFC parameter varied from 0.38 to 1.0 with different flow conditions, suggesting that the AFC parameter was not a sufficient to fully capture the complexity of the flow processes in a one meter sized discrete fracture network
Longxin, M.; Baojun, X.; Shancheng, Z.; Guoqing, H. [CNPC America Ltd., Caracas (Venezuela)
2008-10-15
Horizontal well drilling with cold production were used to develop most of heavy oil fields in Venezuela's Orinoco heavy oil belt. This study interpreted the horizontal well logs of Block M of the Orinoco heavy oil belt in an effort to improve production from this highly porous and permeable reservoir. The reservoir is comprised primarily of non-consolidated sandstones. A porosity calculation formula for the horizontal well without porosity logs was established based on the study of horizontal well logging data of block M in the Orinoco heavy oil belt. A high quality 3-D simulation tool was used to separate the block into several different sections. A set of methods were presented in order to identify if the well track was approaching an adjacent formation, to estimate the distance between the well track and the adjacent formation, and to correct the deep resistivity of the horizontal section affected by the adjacent formation. A set of interpretation techniques were established, based on the combination of well logging data, seismic data and the oilfield development performance data. It was concluded that the development of the precise 3D geological model helped to establish a solid foundation for guiding the well position design and the drilling of the horizontal well. It also contributed to the reservoir numerical simulation and the effective development of the oil field. 6 refs., 2 tabs., 14 figs.
Kosonen, H; Valkama, S; Hartikainen, J; Eerikainen, H; Torkkeli, M; Jokela, K; Serimaa, R; Sundholm, F; ten Brinke, G; Ikkala, O; Eerikäinen, Hannele
2002-01-01
We report self-organized polymer electrolytes based on poly(styrene)-block-poly(4-vinylpyridine) (PS-block-P4VP). Liquidlike ethylene oxide (EO) oligomers with sulfonic acid end groups are bonded to the P4VP block, leading to comb-shaped supramolecules with the PS-block-P4VP backbone. Lithium perchl
We introduce a fast block-iterative maximum a posteriori (MAP) reconstruction algorithm and apply it to four-dimensional reconstruction of gated SPECT perfusion studies. The new algorithm, called RBI-MAP, is based on the rescaled block iterative EM (RBI-EM) algorithm. We develop RBI-MAP based on similarities between the RBI-EM, ML-EM and MAP-EM algorithms. RBI-MAP requires far fewer iterations than MAP-EM, and so should result in acceleration similar to that obtained from using RBI-EM or OS-EM as opposed to ML-EM. When complex four-dimensional clique structures are used in the prior, however, evaluation of the smoothing prior dominates the processing time. We show that a simple scheme for updating the prior term in the heart region only for RBI-MAP results in savings in processing time of a factor of six over MAP-EM. The RBI-MAP algorithm incorporating 3D collimator-detector response compensation is demonstrated on a simulated 99mTc gated perfusion study. Results of RBI-MAP are compared with RBI-EM followed by a 4D linear filter. For the simulated study, we find that RBI-MAP provides consistently higher defect contrast for a given degree of noise smoothing than does filtered RBI-EM. This is an indication that RBI-MAP smoothing does less to degrade resolution gained from 3D detector response compensation than does a linear filter. We conclude that RBI-MAP can provide smooth four-dimensional reconstructions with good visualization of heart structures in clinically realistic processing times. (author)
Aydin, Fikret; Chu, Xiaolei; Uppaladadium, Geetartha; Devore, David; Goyal, Ritu; Murthy, N Sanjeeva; Zhang, Zheng; Kohn, Joachim; Dutt, Meenakshi
2016-04-21
The dissipative particle dynamics (DPD) simulation technique is a coarse-grained (CG) molecular dynamics-based approach that can effectively capture the hydrodynamics of complex systems while retaining essential information about the structural properties of the molecular species. An advantageous feature of DPD is that it utilizes soft repulsive interactions between the beads, which are CG representation of groups of atoms or molecules. In this study, we used the DPD simulation technique to study the aggregation characteristics of ABA triblock copolymers in aqueous medium. Pluronic polymers (PEG-PPO-PEG) were modeled as two segments of hydrophilic beads and one segment of hydrophobic beads. Tyrosine-derived PEG5K-b-oligo(desaminotyrosyl tyrosine octyl ester-suberate)-b-PEG5K (PEG5K-oligo(DTO-SA)-PEG5K) block copolymers possess alternate rigid and flexible components along the hydrophobic oligo(DTO-SA) chain, and were modeled as two segments of hydrophilic beads and one segment of hydrophobic, alternate soft and hard beads. The formation, structure, and morphology of the initial aggregation of the polymer molecules in aqueous medium were investigated by following the aggregation dynamics. The dimensions of the aggregates predicted by the computational approach were in good agreement with corresponding results from experiments, for the Pluronic and PEG5K-oligo(DTO-SA)-PEG5K block copolymers. In addition, DPD simulations were utilized to determine the critical aggregation concentration (CAC), which was compared with corresponding results from an experimental approach. For Pluronic polymers F68, F88, F108, and F127, the computational results agreed well with experimental measurements of the CAC measurements. For PEG5K-b-oligo(DTO-SA)-b-PEG5K block polymers, the complexity in polymer structure made it difficult to directly determine their CAC values via the CG scheme. Therefore, we determined CAC values of a series of triblock copolymers with 3-8 DTO-SA units using DPD
Herbsthofer, Laurin; Truhetz, Heimo
2016-04-01
We use the Froude number of continuum mechanics to study the flow behaviour in the Alpine region, especially to identify flow-above and blocked-flow situations for model evaluation purposes. Using the wind speed of an air parcel U, the Brunt-Väisälä frequency N (describing buoyancy and taking moisture and condensation into account) as well as the barrier height h of a mountain the Froude number F can be easily calculated using F=U/Nh. F therefore represents the ratio of kinetic energy of an air parcel to the potential energy required to surmount a barrier. High values of F then indicate flow-above, while F<1 represent blocked-flow situations. In the framework of the project NHCM-2 (www.nhcm-2.eu), funded by the Austrian Science Fund (FWF, project ID P24758-N29), we use this method to analyse the differences between the regional climate models COSMO-CLM and WRF, operated on convection permitting scale (3 km grid spacing), and the analysis fields from the operational Swiss forecast system COSMO-7 (7 km grid spacing). Calculating a two-dimensional field of F values for a layer of interest (e.g. constant geometric height of 1500 meters), we introduce different flow categories (such as flow-above and blocked-flow and taking local stability into account) and study their frequency of occurrence based on hourly data. First results from a test period (November 2002) show that differences between COSMO-CLM and COSMO-7 in areas close to the Alps are usually larger than in areas further away. However, there are some subregions (especially the Po Valley as well as the regions from Burgundy to Southern Germany) that show a clear over- or underestimation of these categories. Detailed results for an extended period (including WRF) will be presented.
Ameri, Mohsen; Samavat, Feridoun; Mohajerani, Ezeddin; Fathollahi, Mohammad-Reza
2016-06-01
In the present research, the effect of \\text{ZnO} -based blocking layers on the operational features of \\text{Ti}{{\\text{O}}2} -based dye-sensitized solar cells is investigated. A facile solution-based coating method is applied to prepare an interfacial highly transparent \\text{ZnO} compact blocking layer (CBL) to enhance the efficiency of dye-sensitized solar cells. Different precursor molar concentration were tested to find the optimum concentration. Optical and electrical measurements were carried out to confirm the operation of the CBLs. Morphological characterizations were performed by scanning electron microscopy (SEM) and atomic force microscopy (AFM) to investigate the structure of the compact layers. We have also developed a set of modeling procedures to extract the effective electrical parameters including the parasitic resistances and charged carrier profiles to investigate the effect of CBLs on the dye-sensitized solar cell (DSSC) performance. The adopted modeling approach should establish a versatile framework for diagnosis of DSSCs and facilitates the exploration of critical factors influencing device performance.
Dey, Aloke
2010-01-01
This book presents a systematic, rigorous and comprehensive account of the theory and applications of incomplete block designs. All major aspects of incomplete block designs are considered by consolidating vast amounts of material from the literature - the classical incomplete block designs, like the balanced incomplete block (BIB) and partially balanced incomplete block (PBIB) designs. Other developments like efficiency-balanced designs, nested designs, robust designs, C-designs and alpha designs are also discussed, along with more recent developments in incomplete block designs for special t
Zoladz, Phillip R; Fleshner, Monika; Diamond, David M
2013-07-01
Individuals exposed to life-threatening trauma are at risk for developing post-traumatic stress disorder (PTSD), a debilitating condition that involves persistent anxiety, intrusive memories and several physiological disturbances. Current pharmacotherapies for PTSD manage only a subset of these symptoms and typically have adverse side effects which limit their overall effectiveness. We evaluated the effectiveness of three different pharmacological agents to ameliorate a broad range of PTSD-like symptoms in our established predator-based animal model of PTSD. Adult male Sprague-Dawley rats were given 1-h cat exposures on two occasions that were separated by 10 days, in conjunction with chronic social instability. Beginning 24 h after the first cat exposure, rats received daily injections of amitriptyline, clonidine, tianeptine or vehicle. Three weeks after the second cat exposure, all rats underwent a battery of behavioral and physiological tests. The vehicle-treated, psychosocially stressed rats demonstrated a robust fear memory for the two cat exposures, as well as increased anxiety expressed on the elevated plus maze, an exaggerated startle response, elevated heart rate and blood pressure, reduced growth rate and increased adrenal gland weight, relative to the vehicle-treated, non-stressed (control) rats. Neither amitriptyline nor clonidine was effective at blocking the entire cluster of stress-induced sequelae, and each agent produced adverse side effects in control subjects. Only the antidepressant tianeptine completely blocked the effects of psychosocial stress on all of the physiological and behavioral measures that were examined. These findings illustrate the differential effectiveness of these three treatments to block components of PTSD-like symptoms in rats, and in particular, reveal the profile of tianeptine as the most effective of all three agents. PMID:23318688
Yucca Mountain, Nevada is underlain by 14.0 to 11.6 Ma volcanic rocks tilted eastward 3 degree to 20 degree and cut by faults that were primarily active between 12.7 and 11.6 Ma. A three-dimensional computer-based model of the central block of the mountain consists of seven structural subblocks composed of six formations and the interstratified-bedded tuffaceous deposits. Rocks from the 12.7 Ma Tiva Canyon Tuff, which forms most of the exposed rocks on the mountain, to the 13.1 Ma Prow Pass Tuff are modeled with 13 surfaces. Modeled units represent single formations such as the Pah Canyon Tuff, grouped units such as the combination of the Yucca Mountain Tuff with the superjacent bedded tuff, and divisions of the Topopah Spring Tuff such as the crystal-poor vitrophyre interval. The model is based on data from 75 boreholes from which a structure contour map at the base of the Tiva Canyon Tuff and isochore maps for each unit are constructed to serve as primary input. Modeling consists of an iterative cycle that begins with the primary structure-contour map from which isochore values of the subjacent model unit are subtracted to produce the structure contour map on the base of the unit. This new structure contour map forms the input for another cycle of isochore subtraction to produce the next structure contour map. In this method of solids modeling, the model units are presented by surfaces (structure contour maps), and all surfaces are stored in the model. Surfaces can be converted to form volumes of model units with additional effort. This lithostratigraphic and structural model can be used for (1) storing data from, and planning future, site characterization activities, (2) preliminary geometry of units for design of Exploratory Studies Facility and potential repository, and (3) performance assessment evaluations
Seda, P E; McAnulty, J H; Anderson, C J
1980-01-01
A patient presented with orthostatic dizziness and syncope caused by postural heart block. When the patient was supine, atrioventricular conduction was normal and he was asymptomatic; when he was standing he developed second degree type II block and symptoms. The left bundle-branch block on his electrocardiogram and intracardiac electrophysiological study findings suggest that this heart block occurred distal to the His bundle. Orthostatic symptoms are usually presumed to be secondary to an i...
Application of multi-block methods in cement production
Svinning, K.; Høskuldsson, Agnar
2008-01-01
Compressive strength at 1 day of Portland cement as a function of the microstructure of cement was statistically modelled by application of multi-block regression method. The observation X-matrix was partitioned into four blocks, the first block representing the mineralogy, the second particle size...... distribution and the two last blocks the superficial microstructure analysed by differential thermo gravimetric analysis. The multi-block method is used to identify the role of each part. The score vectors of each block can be analysed separately or together with score vectors of other blocks. Stepwise...... regression is used to find minimum number of variables of each block. The multi-block method proved useful in determining the modelling strength of each data block and finding minimum number of variables within each data block....
I. J. Maasilta
2012-12-01
Full Text Available The responsivity and noise of a voltage-biased superconducting transition-edge sensor depends strongly on the details of its thermal model, and the simplest theory for TES response assumes a single heat capacity connected to the heat bath. Here, analytical results are derived and discussed for the complex impedance, the responsivity and the noise of a transition-edge sensor, when the thermal model is not simple but consists of either two or three connected heat capacities. The implications of the differences of the models are discussed, as well.
Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury
Duan Yingli
2012-01-01
Full Text Available Abstract Background Proline-rich tyrosine kinase 2 (Pyk2 is essential in neutrophil degranulation and chemotaxis in vitro. However, its effect on the process of lung inflammation and edema formation during LPS induced acute lung injury (ALI remains unknown. The goal of the present study was to determine the effect of inhibiting Pyk2 on LPS-induced acute lung inflammation and injury in vivo. Methods C57BL6 mice were given either 10 mg/kg LPS or saline intratracheally. Inhibition of Pyk2 was effected by intraperitoneal administration TAT-Pyk2-CT 1 h before challenge. Bronchoalveolar lavage analysis of cell counts, lung histology and protein concentration in BAL were analyzed at 18 h after LPS treatment. KC and MIP-2 concentrations in BAL were measured by a mouse cytokine multiplex kit. The static lung compliance was determined by pressure-volume curve using a computer-controlled small animal ventilator. The extravasated Evans blue concentration in lung homogenate was determined spectrophotometrically. Results Intratracheal instillation of LPS induced significant neutrophil infiltration into the lung interstitium and alveolar space, which was attenuated by pre-treatment with TAT-Pyk2-CT. TAT-Pyk2-CT pretreatment also attenuated 1 myeloperoxidase content in lung tissues, 2 vascular leakage as measured by Evans blue dye extravasation in the lungs and the increase in protein concentration in bronchoalveolar lavage, and 3 the decrease in lung compliance. In each paradigm, treatment with control protein TAT-GFP had no blocking effect. By contrast, production of neutrophil chemokines MIP-2 and keratinocyte-derived chemokine in the bronchoalveolar lavage was not reduced by TAT-Pyk2-CT. Western blot analysis confirmed that tyrosine phosphorylation of Pyk2 in LPS-challenged lungs was reduced to control levels by TAT-Pyk2-CT pretreatment. Conclusions These results suggest that Pyk2 plays an important role in the development of acute lung injury in mice and
Santos, Roberto Hugo Melo dos; Figueiro, Wilson Mouzer [Bahia Univ., Salvador, BA (Brazil). Inst. de Geociencias]. E-mail: rms@cpgg.ufba.br; fgueiro@cpgg.ufba.br
2003-07-01
The developed algorithm in this work was based on the finite difference method applied to the wave equation, assuming that the Earth has an acoustic behavior. The seismic modeling was implemented numerically by means of the finite differences method (MDF), employing regular nets, and applied to the derivatives of time and fourth order to derivatives of the space. Two-dimensional geological models was represented by two distinct kind of parametrizations: in blocs (P B) and using trigonometric polynomials (PPT). With the objective of jumping the advantages of using the PPT front P B, mainly in what it tells respect the economy of space of memory in program of finite difference and simplification of the equation in the inversion strategies, simulations of the propagation of waves ware presented in several models acted by different parametrizations (P B and PPT) using applied MDF the equation of the wave and generating synthetic seismograms that they are compared amongst themselves. As a result of this work we can detach the great economy of space of memory in the use of PPT, in whole PPT the model is defined for the coefficients of the polynomial that start to be the parameters of the model, and PPT simplifies the representation of more complicated models. (author)
Jönsson, Jeppe
2015-01-01
shows that no readily available tests with a well-defined substantial eccentricity have been performed. This paper presents theoretical and experimental work leading towards generalized block failure capacity methods. Simple combination of normal force, shear force and moment stress distributions along......Block tearing is considered in several codes as a pure block tension or a pure block shear failure mechanism. However in many situations the load acts eccentrically and involves the transfer of a substantial moment in combination with the shear force and perhaps a normal force. A literature study...... yield lines around the block leads to simple interaction formulas similar to other interaction formulas in the codes....
Block Scheduling: Center for School Success Promising Practices Series
Imbimbo, Josephine; Gilkes, Alwyn
2009-01-01
This publication focuses on block scheduling. Alternative scheduling models--usually called "block scheduling" because they involve blocks of time for student learning--restructure the school day. Schools may adopt block scheduling to create more productive and personal relationships among teachers and students, to design challenging curricula…
Orlov Anton S.
2015-01-01
Full Text Available This article investigates electrolyte filtration in the bottom of the aluminum electrolyzer cathode device using the mathematical modeling. Penetration of molten electrolyte in the heat insulation part of the lining is one of the main reasons of electrolyzer premature shutdown, because it leads to bottom destruction and excessive heat loss. This problem is considered a two-phase filtration of incompressible immiscible liquids in an inhomogeneous non-deformable porous body. The verification of the model on the problem of water filtration pin a porous medium has confirmed its adequacy. With the help of the developed mathematical model the dynamics of the impregnation of the lining of the cathode and electrolyte device defined thermal balance baths. Research has identified the speed of penetration of the melt in the bottom of the bath during service of the electrolyzer.
Ota, Shinichi; Geschwind, Jean-Francois H; Buijs, Manon; Wijlemans, Joost W; Kwak, Byung Kook; Ganapathy-Kanniappan, Shanmugasundaram
2013-06-01
Studies in animal models of cancer have demonstrated that targeting tumor metabolism can be an effective anticancer strategy. Previously, we showed that inhibition of glucose metabolism by the pyruvate analog, 3-bromopyruvate (3-BrPA), induces anticancer effects both in vitro and in vivo. We have also documented that intratumoral delivery of 3-BrPA affects tumor growth in a subcutaneous tumor model of human liver cancer. However, the efficacy of such an approach in a clinically relevant orthotopic tumor model has not been reported. Here, we investigated the feasibility of ultrasound (US) image-guided delivery of 3-BrPA in an orthotopic mouse model of human pancreatic cancer and evaluated its therapeutic efficacy. In vitro, treatment of Panc-1 cells with 3-BrPA resulted in a dose-dependent decrease in cell viability. The loss of viability correlated with a dose-dependent decrease in the intracellular ATP level and lactate production confirming that disruption of energy metabolism underlies these 3-BrPA-mediated effects. In vivo, US-guided delivery of 3-BrPA was feasible and effective as demonstrated by a marked decrease in tumor size on imaging. Further, the antitumor effect was confirmed by (1) a decrease in the proliferative potential by Ki-67 immunohistochemical staining and (2) the induction of apoptosis by terminal deoxynucleotidyl transferase-mediated deoxyuridine 5-triphospate nick end labeling staining. We therefore demonstrate the technical feasibility of US-guided intratumoral injection of 3-BrPA in a mouse model of human pancreatic cancer as well as its therapeutic efficacy. Our data suggest that this new therapeutic approach consisting of a direct intratumoral injection of antiglycolytic agents may represent an exciting opportunity to treat patients with pancreas cancer. PMID:23529644
地震资料在车古201块储层建模中的应用%Application of Seismic Data to Reservoir Modeling of the Chegu 201 Block
蔡毅; 张祥忠; 张新赏
2005-01-01
Great uncertainty exists in reservoir models built for blocks where well spacing is uneven or large. The uncertainty in reservoir models can be significantly reduced by using Coordinate Cokriging Sequential Gaussian Simulation technology, in combination with the restriction of seismic characteristic data. Satisfactory reservoir parameter interpolation results, which are more accurate than those derived only from borehole data, are obtained, giving rise to a reasonable combination of widespread and dense-sampled seismic (soft data) data with borehole data (hard data). A significant effect has been made in reservoir parameter modeling in the Chegu 201 block of the Futai Oilfield by using this technology.
Blocked randomization with randomly selected block sizes.
Efird, Jimmy
2011-01-01
When planning a randomized clinical trial, careful consideration must be given to how participants are selected for various arms of a study. Selection and accidental bias may occur when participants are not assigned to study groups with equal probability. A simple random allocation scheme is a process by which each participant has equal likelihood of being assigned to treatment versus referent groups. However, by chance an unequal number of individuals may be assigned to each arm of the study and thus decrease the power to detect statistically significant differences between groups. Block randomization is a commonly used technique in clinical trial design to reduce bias and achieve balance in the allocation of participants to treatment arms, especially when the sample size is small. This method increases the probability that each arm will contain an equal number of individuals by sequencing participant assignments by block. Yet still, the allocation process may be predictable, for example, when the investigator is not blind and the block size is fixed. This paper provides an overview of blocked randomization and illustrates how to avoid selection bias by using random block sizes. PMID:21318011
Blocked Randomization with Randomly Selected Block Sizes
Jimmy Efird
2010-12-01
Full Text Available When planning a randomized clinical trial, careful consideration must be given to how participants are selected for various arms of a study. Selection and accidental bias may occur when participants are not assigned to study groups with equal probability. A simple random allocation scheme is a process by which each participant has equal likelihood of being assigned to treatment versus referent groups. However, by chance an unequal number of individuals may be assigned to each arm of the study and thus decrease the power to detect statistically significant differences between groups. Block randomization is a commonly used technique in clinical trial design to reduce bias and achieve balance in the allocation of participants to treatment arms, especially when the sample size is small. This method increases the probability that each arm will contain an equal number of individuals by sequencing participant assignments by block. Yet still, the allocation process may be predictable, for example, when the investigator is not blind and the block size is fixed. This paper provides an overview of blocked randomization and illustrates how to avoid selection bias by using random block sizes.
BLOCK H-MATRICES AND SPECTRUM OF BLOCK MATRICES
黄廷祝; 黎稳
2002-01-01
The block H-matrices are studied by the concept of G-functions, several concepts of block matrices are introduced. Equivalent characters of block H-matrices are obtained. Spectrum localizations claracterized by Gfunctions for block matrices are got.
Geostatistical methods are applied for modeling the mineral deposits at the final stage of the detailed exploration. By applying the results of these models, the technical and economic feasibility studies are conducted for the deposits. The geostatistical modeling methods are usually consist of estimation and simulation methods. The estimation techniques, such as Kriging, construct spatial relation (geological continuation model) between data, by providing the best unique guesses for unknown features. However, when applying this technique for a grid of drill-holes over a deposit, an obvious discrepancy exists between the real geological features and the Kriging estimation map. Because of the limited number of sampled data applied for Kriging, it could not appear as the same as the real features. Also the spatial continuity estimated by the Kriging maps, are smoother than the real unknown features. On the other hand, the objective of simulation is to provide some functions or sets of variable values, to be compatible with the existing information. This means that the simulated values have an average and the variance similar to the raw data and may even be the same as the measurements. we studied the Anomaly No.3 of Narigan uranium mineral deposit, located in the central Iran region and applied the Kriging estimation and the sequential Gaussian simulation methods, and finally by comparing the results we concluded that the Kriging estimation method is more reliable for long term planning of a mine. Because of the reconstructing random structures, the results of the simulation methods indicate that they could also be applied for short term planning in mine exploitation.
Huan ZHAO
2015-06-01
Full Text Available The second tertiary combined model is applied to develop the second and third type reservoirs which have more oil layer quantity and strong anisotropism, compared to the regular main reservoir with polymer injection, whose seepage characteristics of polymer-injection-after-water-drive shows a remarkable difference, in addition. This development appears to have a larger effect on the remaining oil development and production. Simulating the second tertiary combined model by reservoir numerical simulation under different polymer molecular weight, polymer concentration, polymer injection rate on the polymer injection period, conclusions of the influenced seepage characteristics of original and added perforated interval pressure and water saturation are drawn. The conclusion shows that the polymer molecular weight could influence water saturation of added perforated interval; polymer concentration makes a significant impact on reservoir pressure; polymer injection rate has a great influence on the separate rate of original and added perforated interval. This research provides firm science evidence to the theory of the second tertiary combined model to develop and enhance oil injection-production rate.
Matuska, N.A.; Hess, J.W. [Nevada Univ., Reno, NV (United States). Water Resources Center
1989-08-01
Yucca Mountain, in southern Nevada, is being studied by the Department of Energy and the State of Nevada as the site of a high-level nuclear waste repository. Geochemical and isotopic modeling were used in this study to define the relationship of the volcanic tuff aquifers and aquitards to the underlying regional carbonate ground-water system. The chemical evolution of a ground water as it passes through a hypothetical tuffaceous aquifer was developed using computer models PHREEQE, WATEQDR and BALANCE. The tuffaceous system was divided into five parts, with specific mineralogies, reaction steps and temperatures. The initial solution was an analysis of a soil water from Rainier Mesa. The ending solution in each part became the initial solution in the next part. Minerals consisted of zeolites, smectites, authigenic feldspars and quartz polymorphs from described diagentic mineral zones. Reaction steps were ion exchange with zeolites. The solution from the final zone, Part V, was chosen as most representative, in terms of pH, element molalities and mineral solubilities, of tuffaceous water. This hypothetical volcanic water from Part V was mixed with water from the regional carbonate aquifer, and the results compared to analyses of Yucca Mountain wells. Mixing and modeling attempts were conducted on wells in which studies indicated upward flow.
Yucca Mountain, in southern Nevada, is being studied by the Department of Energy and the State of Nevada as the site of a high-level nuclear waste repository. Geochemical and isotopic modeling were used in this study to define the relationship of the volcanic tuff aquifers and aquitards to the underlying regional carbonate ground-water system. The chemical evolution of a ground water as it passes through a hypothetical tuffaceous aquifer was developed using computer models PHREEQE, WATEQDR and BALANCE. The tuffaceous system was divided into five parts, with specific mineralogies, reaction steps and temperatures. The initial solution was an analysis of a soil water from Rainier Mesa. The ending solution in each part became the initial solution in the next part. Minerals consisted of zeolites, smectites, authigenic feldspars and quartz polymorphs from described diagentic mineral zones. Reaction steps were ion exchange with zeolites. The solution from the final zone, Part V, was chosen as most representative, in terms of pH, element molalities and mineral solubilities, of tuffaceous water. This hypothetical volcanic water from Part V was mixed with water from the regional carbonate aquifer, and the results compared to analyses of Yucca Mountain wells. Mixing and modeling attempts were conducted on wells in which studies indicated upward flow
The gas-cooled high temperature reactor is a concept to produce energy at high temperatures with a high level of inherent safety. It gets special attraction due to e.g. high thermal efficiency and the possibility of hydrogen production. In addition to the PBMR (Pebble Bed Modular Reactor) the (V)HTR (Very high temperature reactor) concept has been established. The basic design of a prismatic HTR consists of the following elements. The fuel is coated with four layers of isotropic materials. These so-called TRISO particles are dispersed into compacts which are placed in a graphite block matrix. The graphite matrix additionally contains holes for the coolant gas. A one-dimensional model is sufficient to describe (the radial) heat transfer in LWRs. But temperature gradients in a prismatic HTR can occur in axial as well as in radial direction, since regions with different heat source release and with different coolant temperature heat up are coupled through the graphite matrix elements. Furthermore heat transfer into reflector elements is possible. DYN3D is a code system for coupled neutron and thermal hydraulics core calculations developed at the Helmholtzzentrum Dresden-Rossendorf. Concerning neutronics DYN3D consists of a two-group and multi-group diffusion approach based on nodal expansion methods. Furthermore a 1D thermal-hydraulics model for parallel coolant flow channels is included. The DYN3D code was extensively verified and validated via numerous numerical and experimental benchmark problems. That includes the NEA CRP benchmarks for PWR and BWR, the Three-Miles-Island-1 main steam line break and the Peach Bottom Turbine Trip benchmarks, as well as measurements carried out in an original-size VVER-1000 mock-up. An overview of the verification and validation activities can be found. Presently a DYN3D-HTR version is under development. It involves a 3D heat conduction model to deal with higher-(than one)-dimensional effects of heat transfer and heat conduction in
Li, Chunjian; Andersen, S. V.
2005-01-01
. The spectral domain formulation of the LMMSE estimator reveals important insight in interfrequency correlations. This is exploited to significantly reduce computational complexity of the estimator. For resource-limited applications such as hearing aids, the performance-to-complexity trade-off can be...... the all-pole model coefficients, and the excitation matrix is built from estimates of the instantaneous power of the excitation sequence. A decision-directed power spectral subtraction method and a modified multipulse linear predictive coding (MPLPC) method are used in these estimations, respectively...
Camille Rolland-Debord
Full Text Available BACKGROUND: Allergic asthma is caused by abnormal immunoreactivity against allergens such as house dust mites among which Dermatophagoides farinae (Der f is a common species. Currently, immunotherapy is based on allergen administration, which has variable effect from patient to patient and may cause serious side effects, principally the sustained risk of anaphylaxis. DNA vaccination is a promising approach by triggering a specific immune response with reduced allergenicity. OBJECTIVE: The aim of the study is to evaluate the effects of DNA immunization with Der f1 allergen specific DNA on allergic sensitization, inflammation and respiratory function in mice. METHODS: Mice were vaccinated 28 and 7 days before allergen exposure with a Der f1-encoding plasmid formulated with a block copolymer. Asthma was induced by skin sensitization followed by intra-nasal challenges with Der f extract. Total lung, broncho-alveolar lavage (BAL and spleen cells were analyzed by flow cytometry for their surface antigen and cytokine expression. Splenocytes and lung cell IFN-γ production by CD8+ cells in response to Der f CMH1-restricted peptides was assessed by ELISPOT. IgE, IgG1 and IgG2a were measured in serum by ELISA. Specific bronchial hyperresponsiveness was assessed by direct resistance measurements. RESULTS: Compared to animals vaccinated with an irrelevant plasmid, pVAX-Der f1 vaccination induced an increase of B cells in BAL, and an elevation of IL-10 and IFN-γ but also of IL-4, IL-13 and IL-17 producing CD4+ lymphocytes in lungs and of IL-4 and IL-5 in spleen. In response to CD8-restricted peptides an increase of IFN-γ was observed among lung cells. IgG2a levels non-specifically increased following block copolymer/DNA vaccination although IgE, IgG1 levels and airways resistances were not impacted. CONCLUSIONS & CLINICAL RELEVANCE: DNA vaccination using a plasmid coding for Der f1 formulated with the block copolymer 704 induces a specific immune response
Lesson Thirteen Trifascicular Block
鲁端; 王劲
2005-01-01
@@ A complete trifascicular block would result in complete AV block. The idio ventricular rhythm has a slower rate and a wide QRS complex because the pacemaker is located at the peripheral part of the conduction system distal to the sites of the block1. Such a rhythm may be difficult to differentiate from bifascicular or bundle branch block combined with complete block at a higher level such as the AV node or His bundle2. Besides a slower ventricular rate, a change in the morphology of the QRS complex from a previous known bifascicular pattern would be strongly suggestive of a trifascicular origin of the complete AV block3. A His bundle recording is required for a definitive diagnosis, however.
Mehl, S.; Hill, M.C.
2002-01-01
A new method of local grid refinement for two-dimensional block-centered finite-difference meshes is presented in the context of steady-state groundwater-flow modeling. The method uses an iteration-based feedback with shared nodes to couple two separate grids. The new method is evaluated by comparison with results using a uniform fine mesh, a variably spaced mesh, and a traditional method of local grid refinement without a feedback. Results indicate: (1) The new method exhibits quadratic convergence for homogeneous systems and convergence equivalent to uniform-grid refinement for heterogeneous systems. (2) Coupling the coarse grid with the refined grid in a numerically rigorous way allowed for improvement in the coarse-grid results. (3) For heterogeneous systems, commonly used linear interpolation of heads from the large model onto the boundary of the refined model produced heads that are inconsistent with the physics of the flow field. (4) The traditional method works well in situations where the better resolution of the locally refined grid has little influence on the overall flow-system dynamics, but if this is not true, lack of a feedback mechanism produced errors in head up to 3.6% and errors in cell-to-cell flows up to 25%. ?? 2002 Elsevier Science Ltd. All rights reserved.