Proposal of a model for sales and operations planning (S&OP maturity evaluation

Directory of Open Access Journals (Sweden)

Carolina Belotti Pedroso

2017-11-01

Full Text Available Abstract A successful S&OP implementation can bring many benefits to organizations, and after its implementation, the S&OP process can evolve and reach higher levels of maturity. Considering that, only through a measurement system, goals and benefits can be achieved, thus, it is essential to assess S&OP maturity level. Many papers on literature adopt a quantitative perspective on S&OP, but just few of them deal with uncertainty present in S&OP decision-making, such as maturity model assessment process that carries subjectivity and uncertainty. Thus, this study proposes a decision making model based on fuzzy theory to evaluate and to categorize S&OP maturity levels and to suggest strategies to increase S&OP maturity. A pilot application was conducted in two manufacturing organizations that have implemented the S&OP process. The results, according to the performance presented, suggest different actions must be taken in terms of ensuring enablers to S&OP implementation.

Time, trust, and transparency: Lessons learned from collecting blood biospecimens for cancer research from the Asian American community.

Science.gov (United States)

Dang, Julie H T; Chen, Moon S

2018-04-01

Biospecimens from racially diverse groups are needed to advance cancer research. The Asian American Cancer Education Study was developed to increase the number and proportion of blood biospecimen donations from Asian Americans for cancer research. The authors' targeted approach included 2 types of community engagement, in-reach (within institution to Asian American patients with cancer) and outreach (external to institution to the general Asian American community). Participants received in-language biospecimen education followed by the opportunity to donate blood biospecimens. Outreach participants donated through our community biospecimen blood drives, and in-reach participants consented to donating an extra tube of blood during their routine blood draws as a patient. Donated blood biospecimens were spun down to serum and plasma to be stored in a biorepository or were sent to the laboratory to test for cancer-related risk factors. Three hundred eighty-eight Asian Americans donated 1127 blood biospecimens for cancer research. Four hundred twenty tubes of plasma and serum are currently being stored at the cancer center's biorepository, 39 tubes have been used for cancer genomic research, and 668 tubes were used to characterize cancer-related risk factors. Building upon the past decade of the National Cancer Institute-funded Asian American Network for Cancer Awareness, Research, and Training's foundation of trust and service among Asian Americans, researchers were able to leverage relationships not only to introduce the idea of biospecimen contribution to the community but to also exceed expectations with regard to the quantity of blood biospecimens collected from Asian Americans. Cancer 2018;124:1614-21. © 2018 American Cancer Society. © 2018 American Cancer Society.

Cirtical role for Salmonella effector SopB in regulating inflammasome activation.

Science.gov (United States)

Hu, Gui-Qiu; Song, Pei-Xuan; Chen, Wei; Qi, Shuai; Yu, Shui-Xing; Du, Chong-Tao; Deng, Xu-Ming; Ouyang, Hong-Sheng; Yang, Yong-Jun

2017-10-01

Salmonella is known to evolve many mechanisms to avoid or delay inflammasome activation which remain largely unknown. In this study, we investigated whether the SopB protein critical to bacteria virulence capacity was an effector that involved in the regulation of inflammasome activation. BMDMs from NLRC4-, NLRP3-, caspase-1/-11-, IFI16- and AIM2-deficient mice were pretreated with LPS, and subsequently stimulated with a series of SopB-related strains of Salmonella, inflammasome induced cell death, IL-1β secretion, cleaved caspase-1 production and ASC speckle formation were detected. We found that SopB could inhibit host IL-1β secretion, caspase-1 activation and inflammasome induced cell death using a series of SopB-related strains of Salmonella; however the reduction of IL-1β secretion was not dependent on sensor that contain PYD domain, such as NLRP3, AIM2 or IFI16, but dependent on NLRC4. Notably, SopB specifically prevented ASC oligomerization and the enzymatic activity of SopB was responsible for the inflammasome inhibition. Furthermore, inhibition of Akt signaling induced enhanced inflammasome activation. These results revealed a novel role in inhibition of NLRC4 inflammasome for Salmonella effector SopB. Copyright © 2017. Published by Elsevier Ltd.

Public perspectives on biospecimen procurement: what biorepositories should consider.

Science.gov (United States)

L'Heureux, Jamie; Murray, Jeffrey C; Newbury, Elizabeth; Shinkunas, Laura; Simon, Christian M

2013-06-01

Human biospecimens are central to biobanking efforts, yet how members of the public think about biobank procurement strategies is not well understood. This study aimed to explore public perspectives toward the procurement of residual clinical material versus "direct" procurement strategies such as the drawing of blood. Members of the public residing in and beyond the biobank catchment area of the University of Iowa Hospitals and Clinics were randomly selected to participate in focus groups and a telephone survey. The majority of survey participants (75%, n=559) found both residual and direct procurement strategies equally workable. Small proportions preferred either residual (15%; n=117) or direct (5%; n=40) procurement. Focus group participants (n=48) could identify benefits to both procurement strategies, but raised concerns about possible donor inconvenience/discomfort and reduced biospecimen accrual in the case of direct procurement. Residual procurement raised concerns about lower-quality samples being procured without full donor awareness. Biobanks should consider that members of the public in their research programs may be willing to make specimen donations regardless of whether a residual or direct procurement strategy is employed. Limiting patient discomfort and inconvenience may make direct procurement strategies more acceptable to some members of the public. Ensuring donor awareness through effective informed consent may allay public concerns about the indirectness of donating clinical biospecimens.

TRWG developmental pathway for biospecimen-based assessment modalities

Energy Technology Data Exchange (ETDEWEB)

Translational Research Working Group; Srivastava, Sudhir; Gray, Joe W.; Reid, Brian J.; Grad, Oren; Greenwood, Addison; Hawk, Ernest T.

2008-09-03

The Translational Research Working Group (TRWG) was created as a national initiative to evaluate the current status of NCI's investment in translational research and envision its future. The TRWG conceptualized translational research as a set of six developmental processes or pathways focused on various clinical goals. One of those pathways describes the development of biospecimen-based assays that utilize biomarkers for the detection, diagnosis, prognosis, and assessment of response to cancer treatment. The biospecimen-based assessment modality (BM) pathway was conceived not as comprehensive description of the corresponding real-world processes, but rather as a tool designed to facilitate movement of a candidate assay through the translational process to the point where it can be handed off for definitive clinical testing. This paper introduces the pathway in the context of prior work and discusses key challenges associated with the biomarker development process in light of the pathway.

Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane.

LENUS (Irish Health Repository)

Knodler, Leigh A

2009-11-01

The Salmonella type III effector, SopB, is an inositol polyphosphate phosphatase that modulates host cell phospholipids at the plasma membrane and the nascent Salmonella-containing vacuole (SCV). Translocated SopB persists for many hours after infection and is ubiquitinated but the significance of this covalent modification has not been investigated. Here we identify by mass spectrometry six lysine residues of SopB that are mono-ubiquitinated. Substitution of these six lysine residues with arginine, SopB-K(6)R, almost completely eliminated SopB ubiquitination. We found that ubiquitination does not affect SopB stability or membrane association, or SopB-dependent events in SCV biogenesis. However, two spatially and temporally distinct events are dependent on ubiquitination, downregulation of SopB activity at the plasma membrane and prolonged retention of SopB on the SCV. Activation of the mammalian pro-survival kinase Akt\\/PKB, a downstream target of SopB, was intensified and prolonged after infection with the SopB-K(6)R mutant. At later times, fewer SCV were decorated with SopB-K(6)R compared with SopB. Instead SopB-K(6)R was present as discrete vesicles spread diffusely throughout the cell. Altogether, our data show that ubiquitination of SopB is not related to its intracellular stability but rather regulates its enzymatic activity at the plasma membrane and intracellular localization.

Market-driven production of biospecimens and the role of NHS hospital-led biobanks.

Science.gov (United States)

Timmons, Stephen; Vezyridis, Paraskevas

2017-09-01

Biobanks are vital for biospecimen production in research, despite the regulatory, recruitment and commercial difficulties they face. We conducted interviews with clinicians, researchers, volunteers who recruit biobank participants, regulators and NHS managers about the integration of a biobank into an NHS hospital. We show that medical waste collected for biomedical research acquires its socio-ethical and economic value from the level of integration (both technologically and organisationally) of the biobank into the NHS hospital. There is extensive investment in a range of intellectual and commercial relationships and labour among stakeholders involved in the production of biospecimens. It is not only the boundaries of research, clinical care and commercialisation of biospecimens that blur but also those of volunteerism and citizenship. Hospital-led biobanks provide an opportunity to study the intertwining of biomedical innovation and healthcare. © 2017 Foundation for the Sociology of Health & Illness.

The State of Cloud-Based Biospecimen and Biobank Data Management Tools.

Science.gov (United States)

Paul, Shonali; Gade, Aditi; Mallipeddi, Sumani

2017-04-01

Biobanks are critical for collecting and managing high-quality biospecimens from donors with appropriate clinical annotation. The high-quality human biospecimens and associated data are required to better understand disease processes. Therefore, biobanks have become an important and essential resource for healthcare research and drug discovery. However, collecting and managing huge volumes of data (biospecimens and associated clinical data) necessitate that biobanks use appropriate data management solutions that can keep pace with the ever-changing requirements of research. To automate biobank data management, biobanks have been investing in traditional Laboratory Information Management Systems (LIMS). However, there are a myriad of challenges faced by biobanks in acquiring traditional LIMS. Traditional LIMS are cost-intensive and often lack the flexibility to accommodate changes in data sources and workflows. Cloud technology is emerging as an alternative that provides the opportunity to small and medium-sized biobanks to automate their operations in a cost-effective manner, even without IT personnel. Cloud-based solutions offer the advantage of heightened security, rapid scalability, dynamic allocation of services, and can facilitate collaboration between different research groups by using a shared environment on a "pay-as-you-go" basis. The benefits offered by cloud technology have resulted in the development of cloud-based data management solutions as an alternative to traditional on-premise software. After evaluating the advantages offered by cloud technology, several biobanks have started adopting cloud-based tools. Cloud-based tools provide biobanks with easy access to biospecimen data for real-time sharing with clinicians. Another major benefit realized by biobanks by implementing cloud-based applications is unlimited data storage on the cloud and automatic backups for protecting any data loss in the face of natural calamities.

Study of Womens Health Across the Nation (SWAN) Biospecimen Repository

Data.gov (United States)

U.S. Department of Health & Human Services — The SWAN Repository is the biospecimen bank of the SWAN study. All stored specimens are from the 3,302 SWAN participants, collected across the 14 clinic visits...

Advancing Translational Space Research Through Biospecimen Sharing: Amplified Impact of Studies Utilizing Analogue Space Platforms

Science.gov (United States)

Staten, B.; Moyer, E.; Vizir, V.; Gompf, H.; Hoban-Higgins, T.; Lewis, L.; Ronca, A.; Fuller, C. A.

2016-01-01

Biospecimen Sharing Programs (BSPs) have been organized by NASA Ames Research Center since the 1960s with the goal of maximizing utilization and scientific return from rare, complex and costly spaceflight experiments. BSPs involve acquiring otherwise unused biological specimens from primary space research experiments for distribution to secondary experiments. Here we describe a collaboration leveraging Ames expertise in biospecimen sharing to magnify the scientific impact of research informing astronaut health funded by the NASA Human Research Program (HRP) Human Health Countermeasures (HHC) Element. The concept expands biospecimen sharing to one-off ground-based studies utilizing analogue space platforms (e.g., Hindlimb Unloading (HLU), Artificial Gravity) for rodent experiments, thereby significantly broadening the range of research opportunities with translational relevance for protecting human health in space and on Earth.

Context-based Sales and Operations Planning (S&OP) research: A literature review and future agenda

DEFF Research Database (Denmark)

Kristensen, Jesper; Jonsson, Patrik

2018-01-01

must be considered when designing and implementing S&OP. Originality/values – This study focused on identifying relevant research on S&OP design by analysing the contribution of literature to a research framework inspired by contingency based research of operations and supply chain management.......&OP design. Research implications – The findings revealed several gaps in the literature on context-dependent S&OP design. To address these gaps, an agenda for future S&OP contingency research is developed. Practical implications – The findings revealed which contextual areas and specific S&OP design issues...

Effect of contouring on bending structural stiffness and bending strength of the 3.5 titanium SOP implant.

Science.gov (United States)

Rutherford, Scott; Ness, Malcolm G

2012-11-01

To compare the bending structural stiffness (BSS) and bending strength (BS) of the 3.5 titanium (Ti) string of pearls (SOP) plate and the 3.5 316LVM stainless steel SOP plate; and the effect of contouring on the BSS and BS of the 3.5 Ti SOP plate. In vitro experimental static 4-point bending materials testing. Twenty-five 3.5 mm Ti and five 3.5 mm 316LVM stainless steel SOP locking bone plates. Each plate was tested in 4-point bending until 10 mm of displacement was achieved. BSS and BS were then calculated for each plate. A 2-sample t-test was used to compare the mean BSS and BS of the different groups. The 3.5 Ti SOP plate had lower mean BSS (0.00263 Nm(2) ) but similar mean BS (12.8 Nm) when compared to the 3.5 316LVM SOP (0.00402 Nm(2) , 13.0 Nm). Prebending the 3.5 Ti SOP diminished its mean BSS (0.00224 Nm(2) ) and mean BS (9.4 Nm) when compared to the Ti control. Pretwisting the 3.5 Ti SOP increased its mean BSS (0.00273 Nm(2) ) but decreased its mean BS (12.4 Nm) when compared to the Ti control. The 3.5 Ti SOP is less stiff but of similar strength to the 3.5 316LVM stainless steel SOP. Prebending the Ti SOP significantly lowers its stiffness and strength. Pretwisting the SOP actually increases its stiffness but slightly lowers its strength. © Copyright 2012 by The American College of Veterinary Surgeons.

A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens.

Science.gov (United States)

Jacobson, Rebecca S; Becich, Michael J; Bollag, Roni J; Chavan, Girish; Corrigan, Julia; Dhir, Rajiv; Feldman, Michael D; Gaudioso, Carmelo; Legowski, Elizabeth; Maihle, Nita J; Mitchell, Kevin; Murphy, Monica; Sakthivel, Mayurapriyan; Tseytlin, Eugene; Weaver, JoEllen

2015-12-15

Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the Text Information Extraction System (TIES) Cancer Research Network, a federated network that facilitates data and biospecimen sharing among member institutions. Member sites can access pathology data that are de-identified and processed with the TIES natural language processing system, which creates a repository of rich phenotype data linked to clinical biospecimens. TIES incorporates multiple security and privacy best practices that, combined with legal agreements, network policies, and procedures, enable regulatory compliance. The TIES Cancer Research Network now provides integrated access to investigators at all member institutions, where multiple investigator-driven pilot projects are underway. Examples of federated search across the network illustrate the potential impact on translational research, particularly for studies involving rare cancers, rare phenotypes, and specific biologic behaviors. The network satisfies several key desiderata including local control of data and credentialing, inclusion of rich phenotype information, and applicability to diverse research objectives. The TIES Cancer Research Network presents a model for a national data and biospecimen network. ©2015 American Association for Cancer Research.

A role for research ethics committees in exchanges of human biospecimens through material transfer agreements.

Science.gov (United States)

Chalmers, Donald; Nicol, Dianne; Nicolás, Pilar; Zeps, Nikolajs

2014-09-01

International transfers of human biological material (biospecimens) and data are increasing, and commentators are starting to raise concerns about how donor wishes are protected in such circumstances. These exchanges are generally made under contractual material transfer agreements (MTAs). This paper asks what role, if any, should research ethics committees (RECs) play in ensuring legal and ethical conduct in such exchanges. It is recommended that RECs should play a more active role in the future development of best practice MTAs involving exchange of biospecimens and data and in monitoring compliance.

Biospecimen repositories and cytopathology.

Science.gov (United States)

Krishnamurthy, Savitri

2015-03-01

Biospecimen repositories are important for the advancement of biomedical research. Literature on the potential for biobanking of fine-needle aspiration, gynecologic, and nongynecologic cytology specimens is very limited. The potential for biobanking of these specimens as valuable additional resources to surgically excised tissues appears to be excellent. The cervicovaginal specimens that can be used for biobanking include Papanicolaou-stained monolayer preparations and residual material from liquid-based cytology preparations. Different types of specimen preparations of fine-needle aspiration and nongynecologic specimens, including Papanicolaou-stained and Diff-Quik-stained smears, cell blocks. and dedicated passes/residual material from fine-needle aspiration stored frozen in a variety of solutions, can be used for biobanking. Because of several gaps in knowledge regarding the standard of operative procedures for the procurement, storage, and quality assessment of cytology specimens, further studies as well as national conferences and workshops are needed not only to create awareness but also to facilitate the use of cytopathology specimens for biobanking. © 2014 American Cancer Society.

Monitoring complex detectors: the uSOP approach in the Belle II experiment

International Nuclear Information System (INIS)

Capua, F. Di; Aloisio, A.; Giordano, R.; Ameli, F.; Anastasio, A.; Izzo, V.; Tortone, G.; Branchini, P.

2017-01-01

uSOP is a general purpose single board computer designed for deep embedded applications in control and monitoring of detectors, sensors and complex laboratory equipments. It is based on the AM3358 (1 GHz ARM Cortex A8 processor), equipped with USB and Ethernet interfaces. On-board RAM and solid state storage allows hosting a full LINUX distribution. In this paper we discuss the main aspects of the hardware and software design and the expandable peripheral architecture built around field busses. We report on several applications of uSOP system in the Belle II experiment, presently under construction at KEK (Tsukuba, Japan). In particular we will report the deployment of uSOP in the monitoring system framework of the endcap electromagnetic calorimeter.

Monitoring complex detectors: the uSOP approach in the Belle II experiment

Science.gov (United States)

Di Capua, F.; Aloisio, A.; Ameli, F.; Anastasio, A.; Branchini, P.; Giordano, R.; Izzo, V.; Tortone, G.

2017-08-01

uSOP is a general purpose single board computer designed for deep embedded applications in control and monitoring of detectors, sensors and complex laboratory equipments. It is based on the AM3358 (1 GHz ARM Cortex A8 processor), equipped with USB and Ethernet interfaces. On-board RAM and solid state storage allows hosting a full LINUX distribution. In this paper we discuss the main aspects of the hardware and software design and the expandable peripheral architecture built around field busses. We report on several applications of uSOP system in the Belle II experiment, presently under construction at KEK (Tsukuba, Japan). In particular we will report the deployment of uSOP in the monitoring system framework of the endcap electromagnetic calorimeter.

[Current modalities and concepts on access and use of biospecimen samples and associated data for research from human biobanks].

Science.gov (United States)

Siddiqui, Roman; Semler, Sebastian Claudius

2016-03-01

It is accepted worldwide that biospecimen and data sharing (BDS) play an essential role for the future of medical research to improve diagnostics and prognostics, e.g. by validated biomarkers. BDS is also pivotal to the development of new therapeutic treatments and for the improvement of population health. Human biobanks can generate an added value to this need by providing biospecimens and/or associated data to researchers. An inspection of several examples of epidemiological as well as clinical/disease-oriented biobanks in Germany shows that best practice procedures (BPP) that are internationally agreed on are being installed for biospecimen and/or data access. In general, fair access is aimed at requiring a written application by the requesting scientist, which is then peer-reviewed for scientific and ethical validity by the Biobank. Applied BPP take into account (i) patient education/agreement according to the informed consent model, (ii) privacy protection, (iii) intellectual property rights, the (iv) notification obligation of health-related findings (including incidental findings), the (v) use of material (MTA) and data transfer agreements (DTA) for mutual legal security, the avoidance of conflicts of interests, as well as for cost recovery/fee for service as a basis for sustainability of the biobank. BPP are rooted in the self-regulation efforts of life sciences and are supported by parent ethics committees in Germany. Central biobank registries displaying aggregated information on biospecimens stored and the research foci constitute an important tool to make biobanks that are scattered across the country visible to each other, and, can thus promote access to hitherto unknown biospecimen and data resources.

Biospecimen quality program in the biobank of the Norwegian Institute of Public Health

Directory of Open Access Journals (Sweden)

Liv Paltiel

2012-04-01

Full Text Available Background: The biological material collected, processed and stored in biobanks are important research tools and it is important to minimize preanalytical variations to provide researchers with high quality biological material that will give reproducible results. Methods: To minimize the preanalytical variations caused by sample collection, processing and storage, we have established a biospecimen quality program. It consists of quality assurance aspects as well as quality control programs to measure adherence to protocols and sample integrity. The quality control program includes measurements and evaluation of the DNA quality and quantity before storage, i.e. concentration, purity, fragmentation and PCR success, and long term storage programs for plasma, urine and RNA. Conclusions: The Biobank at the Norwegian Institute of Public Health has established a biospecimen quality program that ensures high quality specimens and provides the documentation required to use the biomaterial in a best possible way.

DNA fingerprinting: a quality control case study for human biospecimen authentication.

Science.gov (United States)

Kofanova, Olga A; Mathieson, William; Thomas, Gerry A; Betsou, Fotini

2014-04-01

This case study illustrates the usefulness of the DNA fingerprinting method in biobank quality control (QC) procedures and emphasizes the need for detailed and accurate record keeping during processing of biological samples. It also underlines the value of independent third-party assessment to identify points at which errors are most likely to have occurred when unexpected results are obtained from biospecimens.

National Mesothelioma Virtual Bank: A standard based biospecimen and clinical data resource to enhance translational research

Directory of Open Access Journals (Sweden)

Valdivieso Federico A

2008-08-01

Full Text Available Abstract Background Advances in translational research have led to the need for well characterized biospecimens for research. The National Mesothelioma Virtual Bank is an initiative which collects annotated datasets relevant to human mesothelioma to develop an enterprising biospecimen resource to fulfill researchers' need. Methods The National Mesothelioma Virtual Bank architecture is based on three major components: (a common data elements (based on College of American Pathologists protocol and National North American Association of Central Cancer Registries standards, (b clinical and epidemiologic data annotation, and (c data query tools. These tools work interoperably to standardize the entire process of annotation. The National Mesothelioma Virtual Bank tool is based upon the caTISSUE Clinical Annotation Engine, developed by the University of Pittsburgh in cooperation with the Cancer Biomedical Informatics Grid™ (caBIG™, see http://cabig.nci.nih.gov. This application provides a web-based system for annotating, importing and searching mesothelioma cases. The underlying information model is constructed utilizing Unified Modeling Language class diagrams, hierarchical relationships and Enterprise Architect software. Result The database provides researchers real-time access to richly annotated specimens and integral information related to mesothelioma. The data disclosed is tightly regulated depending upon users' authorization and depending on the participating institute that is amenable to the local Institutional Review Board and regulation committee reviews. Conclusion The National Mesothelioma Virtual Bank currently has over 600 annotated cases available for researchers that include paraffin embedded tissues, tissue microarrays, serum and genomic DNA. The National Mesothelioma Virtual Bank is a virtual biospecimen registry with robust translational biomedical informatics support to facilitate basic science, clinical, and translational

76 FR 54528 - Standard Operating Procedures (SOP) of the Aircraft Certification Service (AIR) Process for the...

Science.gov (United States)

2011-09-01

...) of the Aircraft Certification Service (AIR) Process for the Sequencing of Certification and... on the Aircraft Certification Service (AIR) standard operating procedure (SOP) describing the process... comments on the SOP : AIR-100-001; Standard Operating Procedure--Aircraft Certification Service Project...

Integración de un Modelo S&OP con un Modelo ALM

OpenAIRE

Insuasty Chamorro, Andrés Felipe

2015-01-01

DecisionWare International Corp. (DW) Este trabajo presenta los fundamentos metodológicos y la aplicación de la integración de un modelo financiero ALM (Assets Liabilities Management) con los modelos de planificación de la cadena de oferta de una empresa industrial global como son el SCD (Supply Chain Design) y el S&OP (Sales & Operation Planning). La aplicación en este trabajo se concentra en el modelo S&OP vinculado a un modelo ALM. Como resultado práctico se presenta la implementación d...

International Cooperation to Establish Standard Operating Procedure (SOP) for Quarantine Management of Irradiated Foods in International Trade

International Nuclear Information System (INIS)

Lee, J. W.; Byun, M. W.; Kim, J. H.; Choi, J. I.; Song, B. S.; Yoon, Y. H.; Kim, D. H.; Kim, W. G.; Kim, K. P.

2010-02-01

· Development of SOPs through various research activities such as building international cooperation, and analysing current status of food irradiation in domestic and international markets, export and import, international market size, and of R and D - Analysis of examples for quarantine management in agricultural product exporting countries and use of irradiation technology for agricultural product quarantine, and changes in international quarantine management - Analysis of SOPs for food irradiation quarantine in international organization (CODEX, IPPC, WHO). U.S, EU, China, India, and Australia. - Collaborative researches of India/Korea and China/Korea entered into an agreement for market trials · Publishment of irradiation quarantine management SOPs agreed to CODEX standards - Collaborative researches for quarantine management, avoiding Technical Barrier to Trade (TBT), and Sanitary Phytosanitary Measures were conducted, and advanced SOPs agreed with WTO/FTA system were published

Three-dimensional RF SoP technologies: LTCC versus LCP

KAUST Repository

Arabi, Eyad A.; Shamim, Atif

2014-01-01

or cover but is a functional part of the system. The leading multilayer packaging technologies for SoP designs: low temperature co-fired ceramic (LTCC) and liquid crystal polymer (LCP) are compared in this work for the first time. Passive components

International Cooperation to Establish Standard Operating Procedure (SOP) for Quarantine Management of Irradiated Foods in International Trade

Energy Technology Data Exchange (ETDEWEB)

Lee, J. W.; Byun, M. W.; Kim, J. H.; Choi, J. I.; Song, B. S.; Yoon, Y. H.; Kim, D. H.; Kim, W. G.; Kim, K. P.

2010-02-15

{center_dot} Development of SOPs through various research activities such as building international cooperation, and analysing current status of food irradiation in domestic and international markets, export and import, international market size, and of R and D - Analysis of examples for quarantine management in agricultural product exporting countries and use of irradiation technology for agricultural product quarantine, and changes in international quarantine management - Analysis of SOPs for food irradiation quarantine in international organization (CODEX, IPPC, WHO). U.S, EU, China, India, and Australia. - Collaborative researches of India/Korea and China/Korea entered into an agreement for market trials {center_dot} Publishment of irradiation quarantine management SOPs agreed to CODEX standards - Collaborative researches for quarantine management, avoiding Technical Barrier to Trade (TBT), and Sanitary Phytosanitary Measures were conducted, and advanced SOPs agreed with WTO/FTA system were published

76 FR 54474 - Submission for OMB Review; Comment Request New proposed collection, Biospecimen and Physical...

Science.gov (United States)

2011-09-01

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Submission for OMB Review; Comment Request New proposed collection, Biospecimen and Physical Measures Formative Research Methodology... and Budget (OMB) a request to review and approve the information collection listed below. This...

Standard Operating Procedure (SOP) on Planting and Maintenance of Orchid at Malaysian Nuclear Agency

International Nuclear Information System (INIS)

Othman Abu Sari; Suhaimi Musa; Affrida Abu Hassan

2015-01-01

Research on orchid mutation breeding has been carried out at Malaysian Nuclear Agency since 1990s. In this study, a large number of irradiated orchid seedlings were planted for screening and the mutants obtained were propagated from time to time. Care should be taken to make sure plants are healthy, hence resulted in reliable and accurate data. For this purpose, SOP for orchid cultivation and maintenance need to be developed. A short attachment on training was carried at Hexagon Green Sdn. Bhd orchid farm, Bukit Changgang, Banting. Besides learning the cultivation, maintenance and management of orchids, consequently the experience obtained from this attachment helped in preparing SOP at Malaysian Nuclear Agency. This paper will discuss the SOP on cultivation and maintenance of orchid from the hardening until maturation stage in the glass house to ensure plants are healthy, produce of high quality flowers and disease free. (author)

[Advantages and disadvantages of different methods for the implementation and the support of standard operating procedures: From PDF files to an app- and webbased SOP management system].

Science.gov (United States)

Bauer, M; Riech, S; Brandes, I; Waeschle, R M

2015-11-01

The quality assurance of care and patient safety, with increasing cost pressure and performance levels is of major importance in the high-risk and high cost area of the operating room (OR). Standard operating procedures (SOP) are an established tool for structuring and standardization of the clinical treatment pathways and show multiple benefits for quality assurance and process optimization. An internal project was initiated in the department of anesthesiology and a continuous improvement process was carried out to build up a comprehensive SOP library. In the first step the spectrum of procedures in anesthesiology was transferred to PDF-based SOPs. The further development to an app-based SOP library (Aesculapp) was due to the high resource expenditure for the administration and maintenance of the large PDF-based SOP collection and to deficits in the mobile availability. The next developmental stage, the SOP healthcare information assistant (SOPHIA) included a simplified and advanced update feature, an archive feature previously missing and notably the possibility to share the SOP library with other departments including the option to adapt each SOP to the individual situation. A survey of the personnel showed that the app-based allocation of SOPs (Aesculapp, SOPHIA) had a higher acceptance than the PDF-based developmental stage SOP form. The SOP management system SOPHIA combines the benefits of the forerunner version Aesculapp with improved options for intradepartmental maintenance and administration of the SOPs and the possibility of an export and editing function for interinstitutional exchange of SOPs.

Modelo de dinâmica de sistemas para o processo de S&OP ampliado

Directory of Open Access Journals (Sweden)

Jean Carlos Domingos

2015-01-01

Full Text Available ResumoApesar de o processo de S&OP (Sales and Operations Planning não ser uma prática nova nas empresas, principalmente naquelas de grande porte, ainda é tema de estudos nas suas práticas e ferramentas computacionais de apoio. Modelos e ferramentas computacionais focadas para o auxílio no processo de S&OP são utilizadas e podem contribuir para a melhoria da qualidade da sua execução e dos seus resultados. As ferramentas mais comuns são aquelas baseadas em planilhas eletrônicas, e as mais sofisticadas, em técnicas de pesquisa operacional inseridas em sistemas APS (Advanced Planning Systems. A partir da revisão bibliográfica realizada sobre teoria e técnicas computacionais usadas para o auxílio do processo de S&OP, foi identificada a ausência de estudos relacionados ao uso de Dinâmica de Sistemas (System Dynamics. Adicionalmente, a revisão aponta a necessidade de estudos relacionados à integração de análise econômica e financeira durante a elaboração dos planos agregados e o uso de variáveis probabilísticas no processo que possibilitem a análise estatística no sentido de fornecer planos mais confiáveis. Outra questão relevante observada é que os gestores que participam do processo de S&OP nem sempre têm uma visão global de todas as variáveis e restrições envolvidas neste processo, assim observa-se também que as técnicas e ferramentas utilizadas para execução do processo de S&OP não oferecem uma visão holística das atividades e variáveis envolvidas. Com isso, neste trabalho, é proposto um modelo de Simulação de Dinâmica de Sistemas que proporcione uma visão holística para o processo de S&OP e que permita a integração com os processos da área financeira e o uso de variáveis probabilísticas. A avaliação dos resultados das simulações realizadas com o modelo, apoiada por um projeto de experimentos (DoE, mostra que os planos gerados são compatíveis se comparados com a prática empresarial

NCI Think Tank Concerning the Identifiability of Biospecimens and “-Omic” Data

OpenAIRE

Weil, Carol J.; Mechanic, Leah E.; Green, Tiffany; Kinsinger, Christopher; Lockhart, Nicole C.; Nelson, Stefanie A.; Rodriguez, Laura L.; Buccini, Laura D.

2013-01-01

On June 11 and 12, 2012, the National Cancer Institute (NCI) hosted a think tank concerning the identifiability of biospecimens and “omic” Data in order to explore challenges surrounding this complex and multifaceted topic. The think tank brought together forty-six leaders from several fields, including cancer genomics, bioinformatics, human subject protection, patient advocacy, and commercial genetics. The first day involved presentations regarding the state of the science of re-identificati...

Studi Kasus Pada Penerapan Sop Inventori Lobby Bar Shangri-la Hotel and Resort Surabaya : Pengamatan Terhadap Prosedur Pengambilan Bahan, Penyimpanan Serta Perlakuan Selama Penyimpanan Bahan

OpenAIRE

Widjojo, Gerald; Kusumawidjaya, Amanda

2013-01-01

Penelitian ini dilakukan untuk mengetahui sejauh mana pemahaman staff dari Lobby Lounge Shangri-La Hotel Surabaya terhadap SOP pada inventori bahan yang ada. SOP ini dirasa penting dalam operasional lobby sehari-hari. Penelitian ini merupakan penelitian deskriptif dengan menggunakan wawancara dan checklist dalam menghasilkan data untuk dianalisa. Hasil penelitian menunjukkan bahwa sebagian besar staf sudah memahami SOP yang ada dan sudah mampu menjalankan SOP yang ada dengan baik.

[Advanced Trauma Life Support (ATLS) in the emergency room. Is it suitable as an SOP?].

Science.gov (United States)

Shafizadeh, S; Tjardes, T; Steinhausen, E; Balke, M; Paffrath, T; Bouillon, B; Bäthis, H

2010-08-01

There is clinical evidence that a standardized management of trauma patients in the emergency room improves outcome. ATLS is a training course that teaches a systematic approach to the trauma patient in the emergency room. The aims are a rapid and accurate assessment of the patient's physiologic status, treatment according to priorities, and making decisions on whether the local resources are sufficient for adequate definitive treatment of the patient or if transfer to a trauma center is necessary. Above all it is important to prevent secondary injury, to realize timing as a relevant factor in the initial treatment, and to assure a high standard of care. A standard operating procedure (SOP) exactly regulates the approach to trauma patients and determines the responsibilities of the involved faculties. An SOP moreover incorporates the organizational structure in the treatment of trauma patients as well as the necessary technical equipment and staff requirements. To optimize process and result quality, priorities are in the fields of medical fundamentals of trauma care, education, and fault management. SOPs and training courses increase the process and result quality in the treatment of the trauma patient in the emergency room. These programs should be based on the special demands of the physiology of the trauma as well as the structural specifics of the hospital. ATLS does not equal an SOP but it qualifies as a standardized concept for management of trauma patients in the emergency room.

24-GHz LTCC Fractal Antenna Array SoP With Integrated Fresnel Lens

KAUST Repository

Ghaffar, Farhan A.; Khalid, Muhammad Umair; Salama, Khaled N.; Shamim, Atif

2012-01-01

A novel 24-GHz mixed low-temperature co-fired ceramic (LTCC) tape based system-on-package (SoP) is presented, which incorporates a fractal antenna array with an integrated grooved Fresnel lens. The four-element fractal array employs a relatively low

Three-dimensional RF SoP technologies: LTCC versus LCP

KAUST Repository

Arabi, Eyad A.

2014-12-18

The system on package (SoP) is an emerging platform, introduced to provide enhanced functionality, and immense miniaturization through vertically integrated passive components in a multilayer process. This way the package is not a mere holder or cover but is a functional part of the system. The leading multilayer packaging technologies for SoP designs: low temperature co-fired ceramic (LTCC) and liquid crystal polymer (LCP) are compared in this work for the first time. Passive components and filters have been implemented in both technologies to show the advantages of the three-dimensional nature of these technologies. The comparison results show that parallel plate capacitors implemented in the ultra-thin LCP provides the highest capacitance density. For spiral inductors, conversely, LTCC inductors have the highest inductances while LCP inductors offer the highest self-resonant frequencies and the highest quality factors (Q). In a circuit level, simulated and measured results of a bandpass filter at 1.5 GHz show that both LCP and LTCC can provide similar performances with an incredible size reduction for the case of ultra-thin LCP. Also, the thin LCP filter exhibits a large degree of mechanical flexibility which makes this technology suitable for future flexible modules.

Estudio del riesgo cardiovascular en pacientes con Síndrome de Ovario Poliquístico (SOP). Creación de grupos de riesgo.

OpenAIRE

García Gamón Valero, Marta

2015-01-01

El SOP es la endocrinopatía más frecuente en la mujer en edad reproductiva. Muchos son los estudios que se han realizado para poder identificar si la presencia del SOP es per se un factor de riesgo cardiovascular. El hecho de que el SOP presente una serie de patologías asociadas que son factores de riesgo cardiovascular hace que sea complicado esclarecer si la elevación del riesgo cardiovascular en estas pacientes se debe fundamentalmente al síndrome. La presencia de factores de confusión com...

Sop-GPU: accelerating biomolecular simulations in the centisecond timescale using graphics processors.

Science.gov (United States)

Zhmurov, A; Dima, R I; Kholodov, Y; Barsegov, V

2010-11-01

Theoretical exploration of fundamental biological processes involving the forced unraveling of multimeric proteins, the sliding motion in protein fibers and the mechanical deformation of biomolecular assemblies under physiological force loads is challenging even for distributed computing systems. Using a C(α)-based coarse-grained self organized polymer (SOP) model, we implemented the Langevin simulations of proteins on graphics processing units (SOP-GPU program). We assessed the computational performance of an end-to-end application of the program, where all the steps of the algorithm are running on a GPU, by profiling the simulation time and memory usage for a number of test systems. The ∼90-fold computational speedup on a GPU, compared with an optimized central processing unit program, enabled us to follow the dynamics in the centisecond timescale, and to obtain the force-extension profiles using experimental pulling speeds (v(f) = 1-10 μm/s) employed in atomic force microscopy and in optical tweezers-based dynamic force spectroscopy. We found that the mechanical molecular response critically depends on the conditions of force application and that the kinetics and pathways for unfolding change drastically even upon a modest 10-fold increase in v(f). This implies that, to resolve accurately the free energy landscape and to relate the results of single-molecule experiments in vitro and in silico, molecular simulations should be carried out under the experimentally relevant force loads. This can be accomplished in reasonable wall-clock time for biomolecules of size as large as 10(5) residues using the SOP-GPU package. © 2010 Wiley-Liss, Inc.

PROFIL PERTUMBUHAN, ENZIMATIS, DAN NUTRISI IKAN BANDENG (Chanos chanos GENERASI KEDUA (G-2 TERSELEKSI DENGAN MENERAPKAN STANDAR OPERASIONAL PROSEDUR (SOP PEMELIHARAAN LARVA

Directory of Open Access Journals (Sweden)

Daniar Kusumawati

2017-12-01

Full Text Available Isu nasional menurunnya produksi budidaya ikan bandeng di tambak pantai utara Pulau Jawa didugasebagai akibat rendahnya kualitas benih produk Hatchery Skala Rumah Tangga (HSRT di Bali, yang secara kontinu merupakan sumber utama pasok benih. Banyak faktor yang mempengaruhi kualitas benih, antara lain kualitas telur dan induk, serta manajemen pemeliharaan induk dan larva. Tujuan penelitian ini adalah untuk mengevaluasi performa pertumbuhan,aktivitas enzim pencernaan dan nutrisi benih ikan bandeng dari HSRT dan generasi kedua (G2 terseleksi yang dipelihara berdasarkan standar operasional prosedur. Penelitian dilakukan di tambak Pejarakan, dengan hewan uji benih produk HSRT dan benih generasi ke-2 (G-2 terseleksi dengan panjang total rata-rata 11,79 ± 1,64 mm, masing-masing dengan padat tebar 5.000 ekor/petak dengan luasan 0,5 Ha/petak, diberi pakan jenis pelet kering berkadar protein 25 % dan dipelihara selama 6 bulan. Hasil penelitian menunjukkan performa benih ikan bandeng dipengaruhi oleh sumber induk dan manajemen pemeliharaan saat larva. Pertumbuhan benih ikan bandeng asal HSRT dengan SOP pemeliharaan larva menunjukkan peningkatan laju pertumbuhan panjang dan bobot sebesar 10,11% dan 47,18% lebih tinggi dibandingkan benih G2-terseleksi, dan 13,82% dan 50,55% lebih tinggi dibandingkan benih HSRT tanpa SOP. Aktivitas enzimatis pada benih HSRT dengan SOP lebih efisien dibandingkan benih G2-terseleksi. Aktivitas enzimatis pada benih HSRT tanpa SOP adalah yang paling rendah dimana hal ini terlihat dari laju pertumbuhannya yang juga paling rendah. Benih HSRT yang dipelihara dengan SOP mampu menekan rasio konversi pakan sebesar 28,29% lebih rendah dibandingkan benih G2-terseleksi, dan 22,64% dibandingkan benih HSRT yang dipelihara tanpa SOP. Currently, there is a national concern regarding the decreasing of milkfish production from ponds in North Java allegedly due to a low quality of milkfish seed produced by small-scale hatcheries in Bali, which

Evaluasi Penerapan Standard Operating Procedure-Good Agriculture Practice (SOP-GAP pada Usahatani Padi Organik di Kabupaten Bantul

Directory of Open Access Journals (Sweden)

Sriyadi Sriyadi

2016-02-01

Full Text Available Food security has meaning not only the availability of adequate food, but also providing security for producers and consumers and ensuring environmental sustainability for sustainable production. Organic farming systems are expected to solve the problem for realizing food security and enhancement of people's welfare. The results of research indicated that, (1 The implementation level of Standard Operating Procedure-Good Agriculture Practice (SOP-GAP of Organic Rice Farming in Bantul district was quite high, (2 The implementation level of SOP-GAP of Organic Rice Farming related to the availability of capital, the selling price and the purchase price of inputs (seeds and fertilizers, (3 The level of the farmer's decision related to the implementation level of SOP-GAP of organic rice farming, and (4 development of organic rice farming required availability of sufficient capital. In this regard the government, particularly the agriculture authority and food security agency need to disburse or facilitate capital for farmers in revolving as well as low interest loans.

The characteristics of the Westinghouse accident procedures and the main differences with SOP

International Nuclear Information System (INIS)

Hu Yan; Gan Peijiang; Sun Chen

2014-01-01

In this note, the Westinghouse operation file system is summarized. The structures of procedures, design methods, implementation logics of the Westinghouse accident procedures are discussed. And compared with the SOP principles, the main differences are clarified. (authors)

Projeto de implementação do processo Sales and Operations Planning (S&OP) - caso de estudo

OpenAIRE

Lima, Daniela Alexandra de Sousa

2017-01-01

Apesar de o conceito de Sales and Operations Planning (S&OP) ter sido introduzido há já algumas décadas, este tem ganho um reconhecimento acrescido, uma vez que a incerteza dos mercados e a crescente complexidade das supply chains aumentam a necessidade de determinar ações futuras e criar um plano de vendas e operações comum. S&OP é um processo multifuncional que promove o desenvolvimento e a aceitação de um plano comum, permitindo o alinhamento entre a oferta e a procura, conecta o planeamen...

CTEPP STANDARD OPERATING PROCEDURE FOR CONDUCTING STAFF AND PARTICIPANT TRAINING (SOP-2.27)

Science.gov (United States)

This SOP describes the method to train project staff and participants to collect various field samples and questionnaire data for the study. The training plan consists of two separate components: project staff training and participant training. Before project activities begin,...

Standard Operation Procedure (SOP) on Planting and Curing of Stevia in Malaysian Nuclear Agency

International Nuclear Information System (INIS)

Norellia Bahari; Norazlina Noordin; Peng, C.S.

2015-01-01

Mutation breeding on stevia study was conducted at the Malaysian Nuclear Agency began in 2012 through the projects under auspices of Science Funs and MOSTI. This research involves the irradiation og gamma rays for acute and chronic tissue culture of stevia. The resulting plant from this tissue cultures process should be planted in a nursery fro the propagation of seedlings for the work of mutant screening potential. For this purpose, the SOP for planting, care and management of stevia has ben developed to ensure that this plant can grow in abundance, disease free and quality. This paper will discuss the SOP including acclimatization techniques of tissue culture plant lets, seedlings and planting in Bio Design Facility, fertilization using fertilizers and planting of trees in the plot for the purpose of potentially screening mutant breeding. (author)

CTEPP STANDARD OPERATING PROCEDURE FOR COLLECTION OF PERSONAL INTERVIEW DATA (SOP-2.21)

Science.gov (United States)

This SOP describes the general method for collecting personal interview data from the child's parent (and the day care center staff, if applicable). Study participants, both parents and day care center teachers, will be interviewed by the project staff at a scheduled appointment ...

24-GHz LTCC Fractal Antenna Array SoP With Integrated Fresnel Lens

KAUST Repository

Ghaffar, Farhan A.

2012-09-30

A novel 24-GHz mixed low-temperature co-fired ceramic (LTCC) tape based system-on-package (SoP) is presented, which incorporates a fractal antenna array with an integrated grooved Fresnel lens. The four-element fractal array employs a relatively low dielectric constant substrate (CT707, εr = 6.4), whereas the lens has been realized on a high-dielectric-constant superstrate (CT765, εr = 68.7 ). The two (substrate and superstrate) are integrated through four corner posts to realize the required air gap (focal distance). The fractal array alone provides a measured gain of 8.9 dBi. Simulations predict that integration of this array with the lens increases the gain by 6 dB. Measurements reveal that the design is susceptible to LTCC fabrication tolerances. In addition to high gain, the SoP provides a bandwidth of 8%. The high performance and compact size (24 × 24 × 4.8 mm3 ) of the design makes it highly suitable for emerging wireless applications such as automotive radar front end.

Context-based Sales and Operations Planning (S&OP) research

DEFF Research Database (Denmark)

Kristensen, Jesper; Jonsson, Patrik

2018-01-01

review. Studies for review were obtained through a keyword search of five relevant databases, manual searches of relevant journals and snowballing of citations in relevant papers. In total, 571 papers published between 2000 and 2017 were assessed, and 68 papers were included in the review. Findings...... – The review found that S&OP design depends on industry, dynamic complexity, detail complexity and organisational characteristics. The findings of the literature review suggest that future research should study the roles of industry, complexity, system and process and organisational characteristics in S...

3D printed System-on-Package (SoP) for environmental sensing and localization applications

KAUST Repository

Zhen, Su; Bilal, Rana Muhammad; Shamim, Atif

2017-01-01

This paper presents for the first time an innovative 3D printed SoP sensor node with temperature, pressure and humidity sensing capabilities. It has an integrated wireless readout through a near isotropic (900MHz) GSM antenna-on-package. This sensor

The Salmonella Effector Protein SopA Modulates Innate Immune Responses by Targeting TRIM E3 Ligase Family Members.

Directory of Open Access Journals (Sweden)

Jana Kamanova

2016-04-01

Full Text Available Salmonella Typhimurium stimulates inflammatory responses in the intestinal epithelium, which are essential for its ability to replicate within the intestinal tract. Stimulation of these responses is strictly dependent on the activity of a type III secretion system encoded within its pathogenicity island 1, which through the delivery of effector proteins, triggers signaling pathways leading to inflammation. One of these effectors is SopA, a HECT-type E3 ligase, which is required for the efficient stimulation of inflammation in an animal model of Salmonella Typhimurium infection. We show here that SopA contributes to the stimulation of innate immune responses by targeting two host E3 ubiquitin ligases, TRIM56 and TRIM65. We also found that TRIM65 interacts with the innate immune receptor MDA5 enhancing its ability to stimulate interferon-β signaling. Therefore, by targeting TRIM56 and TRIM65, SopA can stimulate signaling through two innate immune receptors, RIG-I and MDA5. These findings describe a Salmonella mechanism to modulate inflammatory responses by directly targeting innate immune signaling mechanisms.

Modelo quantitativo para avaliação e melhoria de desempenho do processo de S&OP baseado no diagnóstico e redução de falhas A quantitative model for the assessment and performance improvement of S&OP process based on the diagnosis and reduction of failures

Directory of Open Access Journals (Sweden)

Fabio José Pandim

2012-01-01

Full Text Available O processo de Sales and Operations Planning - Planejamento de Vendas e Operações (S&OP, assim como qualquer processo de nível estratégico ou tático, necessita ter o seu desempenho monitorado para que seja possível realizar ações de melhoria nos aspectos que estejam gerando impactos negativos em seu desempenho. Os modelos para análise de desempenho encontrados na literatura não trazem meios para localizar as causas de ineficiência mais relevantes, quando da utilização de processos S&OP, bem como não fornecem uma maneira de se quantificar o desempenho do processo. Com o objetivo de contribuir com esta necessidade, o presente trabalho apresenta um modelo quantitativo para análise e melhoria de desempenho do processo de S&OP baseado no diagnóstico e na redução de suas ineficiências mais importantes.The S&OP process, like any business process of strategic or tactical level, requires having its performance measured so that, through the monitoring of these measurements, improvement actions for the factors affecting their performance can be created. The models for performance analysis in the literature failed to identify the most relevant causes of inefficiency to the process and do provide a way of measuring the process performance. Therefore, this paper presents a proposal for a quantitative model for the analysis and performance improvement of the S&OP process based on the diagnosis and reduction of its most important inefficiencies.

78 FR 26103 - Proposed Standard Operating Procedure (SOP) of the Aircraft Certification Service (AIR) Project...

Science.gov (United States)

2013-05-03

... data, views, or arguments to the above listed address. Please identify ``SOP: AIR-100-001 Standard... Certification Offices (ACOs). The certification programs include: Type certificate (TC), Amended Type Certificate (ATC), Supplemental Type Certificated ATC), Amended Supplemental Type Certificate (ASTC), and...

Development and evaluation of Standard Operating Procedures (SOPs) for quality control tests and radiological protection activities in a Nuclear Medicine Service

Energy Technology Data Exchange (ETDEWEB)

Krempser, Alexandre R., E-mail: krempser@peb.ufrj.br [Universidade Federal do Rio de Janeiro (PEB/COPPE/UFRJ), RJ (Brazil). Programa de Engenharia Biomedica; Soares, Alexandre B. [Universidade Federal do Rio de Janeiro (IF/UFRJ), Rio de Janeiro, RJ (Brazil). Inst. de Fisica; Corbo, Rossana [Universidade Federal do Rio de Janeiro (FM/UFRJ), Rio de Janeiro, RJ (Brazil). Dept. de Radiologia

2011-07-01

The quality management in Nuclear Medicine Services is a requirement of national and international standards. The Brazilian regulatory agency in health surveillance, the Agencia Nacional de Vigilancia Sanitaria (ANVISA), in its Resolucao de Diretoria Colegiada (Collegiate Directory Resolution) no. 38, requires the elaboration of documents describing the technical and clinical routine activities. This study aimed to elaborate, implement and evaluate Standard Operating Procedures (SOPs) for quality control tests and radiological protection activities in the Nuclear Medicine Service of a university hospital. Eighteen SOPs were developed, involving tasks related to dose calibrator, gamma camera, Geiger-Muller detectors and radiological protection activities. The performance of its application was evaluated for a period of six months. It was observed a reduction in 75% of reported operational errors and 42% of the number of reported incidents with contamination by radioactive material. The SOPs were adequate and successful in its application. New procedures involving clinical activities will also be developed and evaluated. (author)

CTEPP STANDARD OPERATING PROCEDURE FOR CONDUCTING INTERNAL FIELD AUDITS AND QUALITY CONTROL (SOP-2.25)

Science.gov (United States)

This SOP describes the method for conducting internal field audits and quality control procedures. Internal field audits will be conducted to ensure the collection of high quality data. Internal field audits will be conducted by Field Auditors (the Field QA Officer and the Field...

Corporate governance structure which is based in the S&OP process: Case study in la Brazilian cosmetic company

Directory of Open Access Journals (Sweden)

Ximena Rojas

2014-03-01

Full Text Available (Received: 2014/01/31 - Accepted: 2014/03/25This article is about the generation of a corporate governance structure which is based in the process S&OP for a Brazilian cosmetic industry. The increasing emphasis on business development guided by attention to the requirements and demands of customers, cause nowadays, that the organizations of the commercial sectors work in the creation of a competitive differential. The collaborative business management strategy S&OP is looking for the attention of people who are interested in the improvement of their skills; in order to achieve this differential. With the case study methodology, the objectives are to get knowledge, identify, and analyze the characteristics of the company using analysis tools like SWOT, process analysis, value chain. All with the purpose to get a robust management tool that fits with the requirements and demands of the organization. The analyzed results showed that the principles of collaboration and internal communication were the pillars necessary against any attempt of business development. This supports the proposal of a management structure based on the five step S&OP process. As a complement to this study a methodology CPFR was identified as the platform for an integrated work with the rest of the companies of the supply chain.

International Collaboration in Packaging Education: Hands-on System-on-Package (SOP) Graduate Level Courses at Indian Institute of Science and Georgia Tech PRC

OpenAIRE

Varadarajan, Mahesh; Bhattacharya, Swapan; Doraiswami, Ravi; Rao, Ananda G; Rao, NJ; May, Gary; Conrad, Leyla; Tummala, Rao

2005-01-01

System-on-Package (SOP) continues to revolutionize the realization of convergent systems in microelectronics packaging. The SOP concept which began at the Packaging Research Center (PRC) at Georgia Tech has benefited its international collaborative partners in education including the Indian Institute of Science (IISc). The academic program for electronics packaging currently in the Centre for Electronics Design and Technology (CEDT) at IISc is aimed at educating a new breed of globally-compet...

System on Package (SoP) Millimeter Wave Filters for 5G Applications

KAUST Repository

Showail, Jameel

2018-05-01

Bandpass filters are an essential component of wireless communication systems that only transmits frequencies corresponding to the communication band and rejects all other frequencies. As the deployment of 5G draws nearer, first deployments are expected in 2020 [1], the need for viable filters at the new frequency bands becomes more imminent. Size and performance are two critical considerations for a filter that will be used in emerging mobile communication applications. The high frequency of 5G communication, 28 GHz as opposed to sub 6 GHz for nearly all previous communication protocols, means that previously utilized lumped component based solutions cannot be implemented since they are ill-suited for mm-wave applications. The focus of this work is the miniaturization of a high-performance filter. The Substrate Integrated Waveguide (SIW) is a high performance and promising structure and Low Temperature Co-Fired Ceramic (LTCC) is a high-performance material that both can operate at higher frequencies than the technologies used for previous telecommunication generations. To miniaturize the structure, a compact folded four-cavity SIW filter is designed, implemented and tested. The feeding structure is integrated into the filter to exploit the System on Package (SoP) attributes of LTCC and further reduce the total area of the filter individually and holistically when looking at the final integrated system. Two unique three dimensional (3D) integrated SoP LTCC two-stage SIW single cavity filters and one unique four-cavity filter all with embedded planar resonators are designed, fabricated and tested. The embedded resonators create a two-stage effect in a single cavity filter. The better single cavity design provides a 15% fractional bandwidth at a center frequency of 28.12 GHz, and with an insertion loss of -0.53 dB. The fabricated four-cavity filter has a 3-dB bandwidth of .98GHz centered at 27.465 GHz, and with an insertion loss of -2.66 dB. The designs presented

Abrasion Testing of Products Containing Nanomaterials, SOP-R-2: Scientific Operating Procedure Series: Release (R)

Science.gov (United States)

2016-04-01

Nanotechnologies -- Terminology and definitions for nano-objects -- Nanoparticle, nanofibre and nanoplate Definitions Abrasion - wearing away...ER D C SR -1 6- 2 Environmental Consequences of Nanotechnologies Abrasion Testing of Products Containing Nanomaterials, SOP-R-2...ERDC online library at http://acwc.sdp.sirsi.net/client/default. Environmental Consequences of Nanotechnologies ERDC SR-16-2 April 2016

A QUALITATIVE EVALUATION ON SOP HRD 2007-2013 IN ROMANIA - FOCUS-GROUP STUDY

Directory of Open Access Journals (Sweden)

Bud Angelica Mariana

2015-07-01

Full Text Available This paper seeks to underline the main problems faced in implementing and using European Union (EU funds in Romania within the Sectoral Operational Programme Human Resources Development (SOP HRD during the first programing period 2007-2013. The problems and barriers revealed were identified during a focus-group for the second interim evaluation of SOPHRD, organized by the Management Authority of this program in Nord-Vest region, in November 2014. The focus-group represents a small part of the entire process of evaluating the programme for the development of human resources during its implementation, with the purpose of finding beneficiaries opinions about the efficiency, effectiveness and relevance of interventions financed through SOP HRD. Beliefs, personal recommendations from the participants are presented in order to improve the use of European funds for development of human resources (in particular and the use of structural instruments (in general. These results and solutions can be efficiently used during the next financial period 2014-2020 to create the framework for every priority axis and key areas of intervention, during the implementation of new projects and within the entire process that these funds require in order to successfully use the structural instruments to catch up with developed countries. Moreover, some of the problems identified can be found in other operational programmes and therefore, this research can be useful for every one that wants to use this kind of financing or has a project of this kind in implementation, without taking into account the European funding source. Besides the qualitative approach given by focus-group research method, this paper is going to present a general approach over SOP HRD in Romania during 2007-2013, from a quantitative perspective (number of projects submitted, approved, contracted, payment rate, absorption rate. Moreover solutions linked to knowledge management practices will be proposed

CTEPP STANDARD OPERATING PROCEDURE FOR COLLECTION OF SOIL SAMPLES FOR PERSISTENT ORGANIC POLLUTANTS (SOP-2.20)

Science.gov (United States)

This SOP describes the method for collecting soil samples from the child's outdoor play area to measure for persistent organic pollutants. Soil samples are collected by scraping up the top 0.5 cm of soil in a 0.095 m2 (1 ft2) area in the middle of the child's play area.

Contrasting the ethical perspectives of biospecimen research among individuals with familial risk for hereditary cancer and biomedical researchers: implications for researcher training.

Science.gov (United States)

Quinn, Gwendolyn P; Koskan, Alexis; Sehovic, Ivana; Pal, Tuya; Meade, Cathy; Gwede, Clement K

2014-07-01

While ethical concerns about participating in biospecimen research have been previously identified, few studies have reported the concerns among individuals with familial risk for hereditary cancer (IFRs). At the same time, biomedical researchers often lack training in discussing such concerns to potential donors. This study explores IFRs' and biomedical researchers' perceptions of ethical concerns about participating in biobanking research. In separate focus groups, IFRs and biomedical researchers participated in 90-min telephone focus groups. Focus group questions centered on knowledge about laws that protect the confidentiality of biospecimen donors, understanding of informed consent and study procedures, and preferences for being recontacted about potential incidental discovery and also study results. A total of 40 IFRs and 32 biomedical researchers participated in the focus groups. Results demonstrated discrepancies between the perceptions of IFRs and researchers. IFRs' concerns centered on health information protection; potential discrimination by insurers and employers; and preferences for being recontacted upon discovery of gene mutations or to communicate study results. Researchers perceived that participants understood laws protecting donors' privacy and (detailed study information outlined in the informed consent process), study outcomes were used to create a training tool kit to increase researchers' understanding of IFRs' concerns about biobanking.

NCI think tank concerning the identifiability of biospecimens and "omic" data.

Science.gov (United States)

Weil, Carol J; Mechanic, Leah E; Green, Tiffany; Kinsinger, Christopher; Lockhart, Nicole C; Nelson, Stefanie A; Rodriguez, Laura L; Buccini, Laura D

2013-12-01

On 11 and 12 June 2012, the National Cancer Institute hosted a think tank concerning the identifiability of biospecimens and "omic" data in order to explore challenges surrounding this complex and multifaceted topic. The think tank brought together 46 leaders from several fields, including cancer genomics, bioinformatics, human subject protection, patient advocacy, and commercial genetics. The first day involved presentations regarding the state of the science of reidentification; current and proposed regulatory frameworks for assessing identifiability; developments in law, industry, and biotechnology; and the expectations of patients and research participants. The second day was spent by think tank participants in small breakout groups designed to address specific subtopics under the umbrella issue of identifiability, including considerations for the development of best practices for data sharing and consent, and targeted opportunities for further empirical research. We describe the outcomes of this 2-day meeting, including two complementary themes that emerged from moderated discussions following the presentations on day 1, and ideas presented for further empirical research to discern the preferences and concerns of research participants about data sharing and individual identifiability.

Reply [to: Atlantic Tropical Cyclogenetic Processes during SOP-3 NAMMA in the GEOS-5 Global Data Assimilation and Forecast System

Science.gov (United States)

Reale, Oreste; Lau, William K.

2010-01-01

This article is a Reply to a Comment by Scott Braun on a previously published article by O. Reale, K.-M. Lau, and E. Brin: "Atlantic tropical cyclogenetic processes during SOP-3 NAMMA in the GEOS-5 global data assimilation and forecast system", by Reale, Lau and Brin, hereafter referred to as RA09. RA09 investigated the role of the Saharan Air Layer (SAL) in tropical cyclogenetic processes associated with a non-developing easterly wave observed during the Special Observation Period (SOP-3) phase of the 2006 NASA African Monsoon Multidisciplinary Analyses (MAMMA). The wave was chosen because both interact heavily with Saharan air. Results showed: a) very steep moisture gradients are associated with the SAL in forecasts and analyses even at great distance from the Sahara; b) a thermal dipole (warm above, cool below) in the non-developing case. RA09A suggested that radiative effect of dust may play some role in producing a thermal structure less favorable to cyclogenesis, and also indicated that only global horizontal resolutions on the order of 20-30 kilometers can capture the large-scale transport and the fine thermal structure of the SAL Braun (2010) questions those results attributing the wave dissipation to midlatitude air. The core discussion is on a dry filament preceding the wave, on the presence of dust, and on the origin of the air contained in this dry filament. In the 'Reply', higher resolution analyses than the ones used by Braun, taken at almost coincident times with Aqua and Terra passes, are shown, to emphasize how the channel of dry air associated with W1 is indeed rich in dust. Backtrajectories on a higher resolution grid are also performed, leading to results drastically different from Braun (2010), and in particularly showing that there is a clear contribution of Saharan air. Finally, the 'Reply' presents evidence on that analyses at a horizontal resolution of one degree are inadequate to investigate such feature.

Comparative biomarker expression and RNA integrity in biospecimens derived from radical retropubic and robot-assisted laparoscopic prostatectomies.

Science.gov (United States)

Ricciardelli, Carmela; Bianco-Miotto, Tina; Jindal, Shalini; Dodd, Thomas J; Cohen, Penelope A; Marshall, Villis R; Sutherland, Peter D; Samaratunga, Hemamali; Kench, James G; Dong, Ying; Wang, Hong; Clements, Judith A; Risbridger, Gail P; Sutherland, Robert L; Tilley, Wayne D; Horsfall, David J

2010-07-01

Knowledge of preanalytic conditions that biospecimens are subjected to is critically important because novel surgical procedures, tissue sampling, handling, and storage might affect biomarker expression or invalidate tissue samples as analytes for some technologies. We investigated differences in RNA quality, gene expression by quantitative real-time PCR, and immunoreactive protein expression of selected prostate cancer biomarkers between tissues from retropubic radical prostatectomy (RRP) and robot-assisted laparoscopic prostatectomy (RALP). Sections of tissue microarray of 23 RALP and 22 RRP samples were stained with antibodies to androgen receptor (AR) and prostate-specific antigen (PSA) as intersite controls, and 14 other candidate biomarkers of research interest to three laboratories within the Australian Prostate Cancer BioResource tissue banking network. Quantitative real-time PCR was done for AR, PSA (KLK3), KLK2, KLK4, and HIF1A on RNA extracted from five RALP and five RRP frozen tissue cores. No histologic differences were observed between RALP and RRP tissue. Biomarker staining grouped these samples into those with increased (PSA, CK8/18, CKHMW, KLK4), decreased (KLK2, KLK14), or no change in expression (AR, ghrelin, Ki67, PCNA, VEGF-C, PAR2, YB1, p63, versican, and chondroitin 0-sulfate) in RALP compared with RRP tissue. No difference in RNA quality or gene expression was detected between RALP and RRP tissue. Changes in biomarker expression between RALP and RRP tissue exist at the immunoreactive protein level, but the etiology is unclear. Future studies should account for changes in biomarker expression when using RALP tissues, and mixed cohorts of RALP and RRP tissue should be avoided.

Proposals for enhancing tactical planning in grocery retailing with S&OP

DEFF Research Database (Denmark)

Dreyer, Heidi Carin; Kiil, Kasper; Dukovska-Popovska, Iskra

2018-01-01

Purpose-The purpose of this paper is to explore tactical planning in grocery retailing and propose how process and integration mechanisms from sales and operations planning (S&OP) can enhance retail tactical planning.Design/methodology/approach-This work follows an explorative design with case...... studies from the grocery retailing industry in Finland, Norway, and the UK.Findings-The tactical planning process focuses on demand management and securing product availability from suppliers in order to reach sales targets. Less attention is directed toward balancing supply and demand or toward providing...... a single plan to guide company operations. Planning appeared to be functionally oriented with limited coordination between functional plans, but it did include external integration that improved forecast accuracy.Research limitations/implications-The study involves grocery retailer cases with variable...

NCI Think Tank Concerning the Identifiability of Biospecimens and “-Omic” Data

Science.gov (United States)

Weil, Carol J.; Mechanic, Leah E.; Green, Tiffany; Kinsinger, Christopher; Lockhart, Nicole C.; Nelson, Stefanie A.; Rodriguez, Laura L.; Buccini, Laura D.

2014-01-01

On June 11 and 12, 2012, the National Cancer Institute (NCI) hosted a think tank concerning the identifiability of biospecimens and “omic” Data in order to explore challenges surrounding this complex and multifaceted topic. The think tank brought together forty-six leaders from several fields, including cancer genomics, bioinformatics, human subject protection, patient advocacy, and commercial genetics. The first day involved presentations regarding the state of the science of re-identification; current and proposed regulatory frameworks for assessing identifiability; developments in law, industry and biotechnology; and the expectations of patients and research participants. The second day was spent by think tank participants in small break-out groups designed to address specific sub-topics under the umbrella issue of identifiability, including considerations for the development of best practices for data sharing and consent, and targeted opportunities for further empirical research. We describe the outcomes of this two day meeting, including two complimentary themes that emerged from moderated discussions following the presentations on Day 1, and ideas presented for further empirical research to discern the preferences and concerns of research participants about data sharing and individual identifiability. PMID:23579437

Pembuatan Dokumen Sop Keamanan Aset Informasi Yang Mengacu Pada Kontrol Kerangka Kerja Iso 27002:2013 (Studi Kasus : Cv Cempaka Tulungagung

Directory of Open Access Journals (Sweden)

Dheni Indra Rachmawan

2017-03-01

Full Text Available Dalam mendukung proses bisnis utamanya, suatu organisasi membutuhkan adanya dukungan teknologi informasi. Penggunaan Teknologi Informasi di banyak perusahaan telah menjadi satu hal penting dalam meningkatkan efektifitas dan efisiensi operasional bisnis yang mendukung tercapainya tujuan perusahaan, termasuk juga pada CV Cempaka Tulungagung. Dalam memenuhi kebutuhan keamanan aset informasi tersebut maka diperlukan adanya sebuah tata kelola dalam bentuk dokumen SOP (Standard Operating Procedure keamanan aset informasi untuk mengurangi adanya ancaman dan risiko serta untuk mendukung penyelarasan pencapaian tujuan organisasi dalam proses bisnisnya. Metode penelitian yang digunakan yaitu OCTAVE sebagai pengolah hasil informasi yang didapatkan dari wawancara dan FMEA digunakan untuk menghitung seberapa tinggi dampak untuk perusahaan jika risiko itu terjadi dan membuat ranking prioritas untuk masing-masing risiko. Kemudian basis yang digunakan dalam membuat prosedur kendali akses aset informasi sebagai manajemen risiko adalah kerangka kerja ISO/IEC:27002:2013. Dalam penelitian ini, hasil akhir yang didapatkan adalah sebuah dokumen SOP yang sesuai dengan kebutuhan keamanan informasi bagi perusahaan CV Cempaka berdasarkan pada kontrol kerangka kerja ISO27002:2013.

The Semi-opened Infrastructure Model (SopIM): A Frame to Set Up an Organizational Learning Process

Science.gov (United States)

Grundstein, Michel

In this paper, we introduce the "Semi-opened Infrastructure Model (SopIM)" implemented to deploy Artificial Intelligence and Knowledge-based Systems within a large industrial company. This model illustrates what could be two of the operating elements of the Model for General Knowledge Management within the Enterprise (MGKME) that are essential to set up the organizational learning process that leads people to appropriate and use concepts, methods and tools of an innovative technology: the "Ad hoc Infrastructures" element, and the "Organizational Learning Processes" element.

A Tissue Retrieval and Postharvest Processing Regimen for Rodent Reproductive Tissues Compatible with Long-Term Storage on the International Space Station and Postflight Biospecimen Sharing Program

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Vijayalaxmi Gupta

2015-01-01

Full Text Available Collection and processing of tissues to preserve space flight effects from animals after return to Earth is challenging. Specimens must be harvested with minimal time after landing to minimize postflight readaptation alterations in protein expression/translation, posttranslational modifications, and expression, as well as changes in gene expression and tissue histological degradation after euthanasia. We report the development of a widely applicable strategy for determining the window of optimal species-specific and tissue-specific posteuthanasia harvest that can be utilized to integrate into multi-investigator Biospecimen Sharing Programs. We also determined methods for ISS-compatible long-term tissue storage (10 months at −80°C that yield recovery of high quality mRNA and protein for western analysis after sample return. Our focus was reproductive tissues. The time following euthanasia where tissues could be collected and histological integrity was maintained varied with tissue and species ranging between 1 and 3 hours. RNA quality was preserved in key reproductive tissues fixed in RNAlater up to 40 min after euthanasia. Postfixation processing was also standardized for safe shipment back to our laboratory. Our strategy can be adapted for other tissues under NASA’s Biospecimen Sharing Program or similar multi-investigator tissue sharing opportunities.

3D printed System-on-Package (SoP) for environmental sensing and localization applications

KAUST Repository

Zhen, Su

2017-12-22

This paper presents for the first time an innovative 3D printed SoP sensor node with temperature, pressure and humidity sensing capabilities. It has an integrated wireless readout through a near isotropic (900MHz) GSM antenna-on-package. This sensor node is connected to the internet for remote monitoring and has the capability of localization. The paper presents the design of antenna-on-package as well as details of the communication and localization system. Fabrication challenges unique to 3D printing and integration of electronics on 3D printed circuit board are also discussed. Finally, the paper presents measurement results of antenna radiation pattern, return loss, localization accuracy and accuracy of sensing parameters.

Coastal Observations of Weather Features in Senegal during the AMMA SOP-3 Period

Science.gov (United States)

Jenkins, G.; Kucera, P.; Joseph, E.; Fuentes, J.; Gaye, A.; Gerlach, J.; Roux, F.; Viltard, N.; Papazzoni, M.; Protat, A.;

From SOPs to Reports to Evaluations: Learning and Memory ...

Science.gov (United States)

In an era of global trade and regulatory cooperation, consistent and scientifically based interpretation of developmental neurotoxicity (DNT) studies is essential. Because there is flexibility in the selection of test method(s), consistency can be especially challenging for learning and memory tests required by EPA and OECD DNT guidelines (chemicals and pesticides) and recommended for ICH prenatal/postnatal guidelines (pharmaceuticals). A well­ reasoned uniform approach is particularly important for variable endpoints and if non-standard tests are used. An understanding of the purpose behind the tests and expected outcomes is critical, and attention to elements of experimental design, conduct, and reporting can improve study design by the investigator as well as accuracy and consistency of interpretation by evaluators. This understanding also directs which information must be clearly described in study reports. While missing information may be available in standardized operating procedures (SOPs), if not clearly reflected in report submissions there may be questions and misunderstandings by evaluators which could impact risk assessments. A practical example will be presented to provide insights into important variables and reporting approaches. Cognitive functions most often tested in guidelines studies include associative, positional, sequential, and spatial learning and memory in weanling and adult animals. These complex behaviors tap different bra

Sexual Desire and Hypoactive Sexual Desire Disorder in Women. Introduction and Overview. Standard Operating Procedure (SOP Part 1)

DEFF Research Database (Denmark)

Bitzer, Johannes; Giraldi, Annamaria; Pfaus, Jim

2013-01-01

Introduction.  Hypoactive sexual desire disorder (HSDD) is defined in Diagnostic and Statistical Manual of Mental Disorders Fourth Edition as persistent or recurrent deficiency (or absence) of sexual fantasies/thoughts, and/or desire for or receptivity to sexual activity, which causes personal...... must be based on a biopsychosocial, multidimensional, and integrative perspective. Bitzer J, Giraldi A, and Pfaus J. Sexual desire and hypoactive sexual desire disorder in women. Introduction and overview. Standard operating procedure (SOP part 1). J Sex Med **;**:**-**....

General response of Salmonella enterica serovar Typhimurium to desiccation: A new role for the virulence factors sopD and sseD in survival.

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Alice Maserati

Full Text Available Salmonella can survive for long periods under extreme desiccation conditions. This stress tolerance poses a risk for food safety, but relatively little is known about the molecular and cellular regulation of this adaptation mechanism. To determine the genetic components involved in Salmonella's cellular response to desiccation, we performed a global transcriptomic analysis comparing S. enterica serovar Typhimurium cells equilibrated to low water activity (aw 0.11 and cells equilibrated to high water activity (aw 1.0. The analysis revealed that 719 genes were differentially regulated between the two conditions, of which 290 genes were up-regulated at aw 0.11. Most of these genes were involved in metabolic pathways, transporter regulation, DNA replication/repair, transcription and translation, and, more importantly, virulence genes. Among these, we decided to focus on the role of sopD and sseD. Deletion mutants were created and their ability to survive desiccation and exposure to aw 0.11 was compared to the wild-type strain and to an E. coli O157:H7 strain. The sopD and sseD mutants exhibited significant cell viability reductions of 2.5 and 1.3 Log (CFU/g, respectively, compared to the wild-type after desiccation for 4 days on glass beads. Additional viability differences of the mutants were observed after exposure to aw 0.11 for 7 days. E. coli O157:H7 lost viability similarly to the mutants. Scanning electron microscopy showed that both mutants displayed a different morphology compared to the wild-type and differences in production of the extracellular matrix under the same conditions. These findings suggested that sopD and sseD are required for Salmonella's survival during desiccation.

Miniaturized and Ferrite Based Tunable Bandpass Filters in LCP and LTCC Technologies for SoP Applications

KAUST Repository

Arabi, Eyad A.

2015-04-01

Wireless systems with emerging applications are leaning towards small size, light-weight and low cost. Another trend for these wireless devices is that new applications and functionalities are being added without increasing the size of the device. To accomplish this, individual components must be miniaturized and the system should be designed to maximize the integration of the individual components. The high level of 3D integration feasible in system on package design (SoP) concept can fulfill the latter requirement. Bandpass filters are important components on all wireless systems to reject the unwanted signals and reduce interference. Being mostly implemented with passive and distributed components, bandpass filters take considerable space in a wireless system. Moreover, with emerging bands and multiple applications encompassed in a single device, many bandpass filters are required. The miniaturization related to bandpass filters can be approached by three main ways: (1) at the component level through the miniaturization of individual bandpass filters, (2) at the system level through the use of tunable filters to reduce the overall number of filters, and (3) at the system level through the high level of integration in a 3D SoP platform. In this work we have focused on all three aspects of miniaturization of band pass filters mentioned above. In the first part of this work, a low frequency (1.5 GHz global positioning system (GPS) band) filter implemented through 3D lumped components in two leading SoP technologies, namely low temperature co-fired ceramic (LTCC) and the liquid crystal polymers (LCP) is demonstrated. The miniaturized filter is based on a second order topology, which has been modified to improve the selectivity and out-of-band rejection without increasing the size. Moreover, for the case of LCP, the filter is realized in an ultra-thin stack up comprising four metallization layers with an overall thickness of only 100 _m. Due to its ultra

Pembuatan Standard Operating Procedure (SOP Service Desk Berdasarkan Kerangka Kerja Itil V3 dengan Menggunakan Metode Analisis Gap Layanan (Studi Kasus: PT. XYZ , Tangerang

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Annisa Rachmi

2014-09-01

Full Text Available Penggunaan Teknologi Informasi di banyak perusahaan telah menjadi satu hal penting dalam meningkatkan efektifitas dan efisiensi operasional bisnis yang mendukung tercapainya tujuan perusahaan, termasuk juga PT XYZ. Unit fungsional service desk sangat dibutuhkan oleh PT XYZ dalam mendukung operasional TI dan menangani permasalahan yang muncul serta memonitor terkait penggunaan TI yang ada di dalam perusahaan. Adanya kebutuhan PT XYZ untuk menjadikan service desk menjadi unit yang dapat berjalan dengan baik sesuai dengan fungsinya, menunjukkan bahwa perlunya penerapan tata kelola TI untuk mengatur dan mengelola aktivitas service desk. Salah satu tata kelola TI yang dimaksud adalah berupa prosedur kerja. Kerangka kerja Information Technology Infrastructure Library (ITIL merupakan suatu best practice yang bertujuan secara berkelanjutan meningkatkan efisiensi operasional TI. Perancangan dan implementasi service desk berdasarkan kerangka kerja ITIL V3 di PT XYZ diperlukan dalam upaya meningkatkan layanan TI dan mengatasi masalah yang ada saat ini. Pembuatan SOP ini diinisialisasi dengan menggunakan metode analisis gap, proses-proses yang dimuat ke dalam SOP merupakan hasil analisis kesenjangan antara kondisi kekinian service desk PT XYZ dengan kondisi ideal service desk framework ITIL.

Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7

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Vanessa M. D’Costa

2015-09-01

Full Text Available Intracellular bacterial pathogens of a diverse nature share the ability to evade host immunity by impairing trafficking of endocytic cargo to lysosomes for degradation, a process that is poorly understood. Here, we show that the Salmonella enterica type 3 secreted effector SopD2 mediates this process by binding the host regulatory GTPase Rab7 and inhibiting its nucleotide exchange. Consequently, this limits Rab7 interaction with its dynein- and kinesin-binding effectors RILP and FYCO1 and thereby disrupts host-driven regulation of microtubule motors. Our study identifies a bacterial effector capable of directly binding and thereby modulating Rab7 activity and a mechanism of endocytic trafficking disruption that may provide insight into the pathogenesis of other bacteria. Additionally, we provide a powerful tool for the study of Rab7 function, and a potential therapeutic target.

The role of zonally asymmetric heating in the vertical and temporal structure of the global scale flow fields during FGGE SOP-1

Science.gov (United States)

Paegle, J.; Kalnay, E.; Baker, W. E.

1981-01-01

The global scale structure of atmospheric flow is best documented on time scales longer than a few days. Theoretical and observational studies of ultralong waves have emphasized forcing due to global scale variations of topography and surface heat flux, possibly interacting with baroclinically unstable or vertically refracting basic flows. Analyses of SOP-1 data in terms of global scale spherical harmonics is documented with emphasis upon weekly transitions.

Método de diagnóstico e análise do S&OP: uma ferramenta para mapeamento do nível de integração do processo e identificação de oportunidades de melhoria

OpenAIRE

Silva, Rafael Bernardes da

2015-01-01

A integração entre os planos estratégico, tático e operacional é um relevante desafio para as organizações. Visando otimizar o alinhamento organizacional, empresas vêm implementando processos de Sales and Operations Planning (S&OP) e desenvolvendo ações para torná-lo robusto. Entende-se o S&OP como um processo de consolidação dos diversos planos organizacionais e direcionamento estratégico do negócio, permitindo o alcance de vantagem competitiva de modo contínuo e integrando os planos de mark...

Strategy and Portfolio Management Aspects of Integrated Business Planning

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Peter Jurečka

2013-03-01

Full Text Available With ongoing globalization and thereof derived growing competitiveness on most markets, companies are under constant pressure to increase the effectiveness and efficiencies of their operations. This article focuses on one of the core business management processes – on planning, namely on Sales and Operations Planning (S&OP and its latest development stage represented by the concept of Integrated Business Planning (IBP. It aims to extend the traditional concept of S&OP for selected topics from business strategy and portfolio management, which structured inclusion into planning represent one of key factors distinguishing IBP from conventional S&OP. Implementation of IBP, which constitutes significant step towards operational excellence, is applicable for almost all business and thus can be used broadly as effective tool for facing the challenges of economic and financial crisis.

Prevalencia de Neospora caninum y DVB en una finca con problemas reproductivos en Sopó (Cundinamarca

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John Fredy García-Chaparro

2015-04-01

Full Text Available La investigación tuvo como objetivo determinar la prevalencia de Neospora caninum y del virus de la diarrea viral bovina (DVB en bovinos de una finca con problemas reproductivos, en el municipio de Sopó (Cundinamarca, y su relación con la presentación de abortos. Se tomaron muestras de suero sanguíneo de 397 animales de alta producción lechera y con antecedentes reproductivos, seleccionados al azar.Se utilizó la inmunofluoresencia indirecta para la N. caninum, y seroneutralización para DVB, y los procedimientos se realizaron en el Laboratorio de Enfermedades Infecciosas de la Universidad de Parma (Italia. Se encontró una prevalencia de 10.37% para DVB con respecto a 21.26% para N. caninum, y estadísticamente no hubo relación directa con respecto a los problemas reproductivos. De acuerdo con los resultados obtenidos, se reportó mayor presencia significativa de N. caninum con relación a la de DVB en el hato lechero objeto de estudio.

Biospecimen Retrieval from NASA's Rodent Research-1: Maximizing Science Return from Flight Missions

Science.gov (United States)

Choi, Sungshin Y.; Chen, Yi-Chun; Reyes, America; Verma, Vandana; Dinh, Marie; Globus, Ruth K.

2016-01-01

Rodent Research (RR)-1 was conducted to validate flight hardware, operations, and science capabilities that were developed to support long duration missions on the International Space Station. After 37 days in microgravity twenty mice were euthanized and frozen on orbit. Upon return to Earth the carcasses were dissected and yielded 32 different types of tissues from each mouse and over 3200 tissue aliquots. Many tissues were distributed to the Space Life and Physical Sciences (SLPS) Biospecimen Sharing Program (BSP) Principal Investigators (PIs) through the Ames Life Science Data Archive (ALSDA). A second round of dissections was performed to collect additional tissues from the remaining carcasses thawed for a second time for additional BSP PIs. Tissues retrieved included vaginal walls, aorta, pelvis, brown adipose tissue, tail, spine and forearms. Although the analyses are still in progress, some of the PIs have reported that the quality of the tissues was acceptable for their study. In a separate experiment we tested the RNA quality of the tissues that were dissected from frozen carcasses that were subjected to euthanasia, freezing, first and second thaw dissections. Timelines simulated the on-orbit RR-1 procedures to assess the quality of the tissues retrieved from the second thaw dissections. We analyzed the RIN values of select tissues including kidney, brain, white adipose tissue (WAT) and brown adipose tissue (BAT). Overall the RIN values from the second thaw were lower compared to those from the first by about a half unit; however, the tissues yielded RNA that are acceptable quality for some quantitative gene expression assays. Interestingly, RIN values of brain tissues were 8.4+/-0.6 and 7.9+/-0.7 from first and second round dissections, respectively (n5). Kidney and WAT yielded RIN values less than 8 but they can still be used for qPCR. BAT yielded higher quality RNA (8.2+/-0.5) than WAT (5.2+/-20.9), possibly due to the high fat content. Together, these

Promoción de alimentación saludable en hogares comunitarios infantiles del municipio de Sopó (Cundinamarca. Colombia) bajo la estrategia de Atención Primaria en Salud

OpenAIRE

Erwin Hernández-Rincón; Diego Severiche-Bueno; Diana Romero-Mayorga; María López-Sánchez; Victoria Espitia-Franco; Adriana Rodríguez-Mancera

2015-01-01

Objetivo: Fortalecer hábitos saludables alimenticios en los hogares infantiles comunita-rios y sus familias en el municipio de Sopó (Cundinamarca, Colombia) desde la Atención Primaria en Salud.Metodología: Investigación-acción participativa realizada con 67 niños de 5 hogares comu-nitarios, sus madres comunitarias, padres de familia y administración municipal durante el segundo semestre de 2014, mediante el abordaje de 3 ejes: 1. Conociendo sobre alimentación saludable, 2. Motivando sobre ali...

Views on clinical trial recruitment, biospecimen collection, and cancer research: population science from landscapes of the Haudenosaunee (People of the Longhouse).

Science.gov (United States)

Haring, Rodney C; Henry, Whitney Ann; Hudson, Maui; Rodriguez, Elisa M; Taualii, Maile

2018-02-01

Biomedical research in culturally distinct communities is often a challenge. Potential barriers to participation occur because science is presented in a format that lacks cultural acknowledgement. Investigations may also fail to showcase beneficial relevance to the communities or include them in true partnership. The history of biomedical research within Native American societies has been complicated by these issues. Historical trauma among many Native groups sometimes transcends into contemporary challenges in both recruitment to and participation particularly in biobanking research. The participants for this study included members of the Haudenosaunee, the People of the Longhouse. Native Americans, including the Haudenosaunee, endure some of the worst health disparities in the country. These include high rates of cancer, obesity, and diabetes which may be linked at least partially to genetic predisposition. Results from a Haudenosaunee urban population shared response on ways to improve recruitment strategies for biospecimen, cancer, and other health-related clinical trials. Mixed methods approaches were used, and community responses indicated the importance of creating trust through respectful partnership; promoting culturally appropriate recruitment materials; the need for a greater understanding of consenting and signature processes; the necessity for concise summary sheets; and a desire to have information that community member understand. Discussion items also include international Indigenous perspectives to biobanking and genetic-related health disparity research.

Tunable bandpass filter based on partially magnetized ferrite LTCC with embedded windings for SoP applications

KAUST Repository

Arabi, Eyad A.

2015-01-01

Tunable filters that are based on ferrite materials often require large and bulky electromagnets. In this work, we present a tunable filter in the Ku-band, which is realized in multilayer ferrite LTCC substrate with embedded bias windings, thus negating the need of a large electromagnet. Also, because of the embedded windings, the bias fields are not lost at the air-substrate interface and therefore the field and current requirements are reduced by an order of magnitude as compared to the previously reported filters. A simulation strategy that uses full permeability tensor with arbitrarily directed magnetic fields has been used to model the filter on a partially magnetized ferrite substrate. Special attention has also been paid to approximate the non-uniform magneto-static fields produced by the embedded windings. The complete design is implemented in 10 layers of ferrite LTCC, making it the first magnetically tunable filter with embedded windings and extremely small size [(5 × 5 × 1.1)mm3]. The filter demonstrates a measured tunability of 4% and an insertion loss of 2.3 dB. With the small form factor, embedded windings, and low bias requirements, the design is highly suitable for compact and tunable SoP applications.

Multivariate two-part statistics for analysis of correlated mass spectrometry data from multiple biological specimens.

Science.gov (United States)

Taylor, Sandra L; Ruhaak, L Renee; Weiss, Robert H; Kelly, Karen; Kim, Kyoungmi

2017-01-01

High through-put mass spectrometry (MS) is now being used to profile small molecular compounds across multiple biological sample types from the same subjects with the goal of leveraging information across biospecimens. Multivariate statistical methods that combine information from all biospecimens could be more powerful than the usual univariate analyses. However, missing values are common in MS data and imputation can impact between-biospecimen correlation and multivariate analysis results. We propose two multivariate two-part statistics that accommodate missing values and combine data from all biospecimens to identify differentially regulated compounds. Statistical significance is determined using a multivariate permutation null distribution. Relative to univariate tests, the multivariate procedures detected more significant compounds in three biological datasets. In a simulation study, we showed that multi-biospecimen testing procedures were more powerful than single-biospecimen methods when compounds are differentially regulated in multiple biospecimens but univariate methods can be more powerful if compounds are differentially regulated in only one biospecimen. We provide R functions to implement and illustrate our method as supplementary information CONTACT: sltaylor@ucdavis.eduSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Desain dan Implementasi Standar Operasional Prosedur (SOP Keamanan Sistem Informasi Fakultas Teknik Universitas Diponegoro Menggunakan Standar ISO 27001

Directory of Open Access Journals (Sweden)

Penji Prasetya

2015-08-01

Full Text Available Like today's modern era, information technology is needed to support the business processes of the organization. In the use of information technology organization must have policies and standard operating procedures are good that any work carried out in the appropriate direction of the organization. Not only that, the organization must also pay attention to information security of any assets owned. This final project aims to make policies and standard operating procedures (SOP and assessing the information security risk in the assets of the organization. In the process of this skripsi refers to the standard of ISO 27001 as the standard for information security management and use of qualitative methodology, where qualitative methodology is a methodology that produces descriptive data in the form of words written or spoken of people and behaviors that can be observed. This final project resulted in the level of risk that is contained in the value of assets and generate recommendations to improve the security controls in the information security of assets based on the clauses of ISO 27001. In accordance with the initial objective of this final project also produce information security policy document and document information security standard operating procedures.

Standard Operating Procedure (SOP) for Rapid and Efficient Production of Stevia Tissue Culture Seedlings

International Nuclear Information System (INIS)

Norazlina Noordin; Peng, C.S.; Rusli Ibrahim

2015-01-01

Stevia rebaudiana Bertoni is a non-caloric natural sweetener which is 300 times sweeter than cane sugar. Extracts from stevia leaves has vast application in food and beverages based industries, can be added to tea and coffee, cooked or baked goods, processed foods and confectionary goods. Recently, stevia attained awareness owing to its natural, non-caloric sweetness by diet/ health conscious and diabetic persons (Arpita et al., 2011). This natural sweetener has high commercial value in global market, it was estimated that global market value for stevia is be around USD11 billion by year 2015. Although stevia is being largely popularized in Malaysia and other countries but large-scale propagation procedures for the continuous supply of planting materials in commercial plantation has yet to be established, optimized and standardized. Furthermore, propagation through stevia seeds is often very difficult due to self-incompatibility which results in sterile seeds (Sakaguchi et al., 1982). Tissue culture is the only rapid process for the mass propagation of stevia and there have been few reports of in vitro growth of stevia (Miyagaya et al., 1986) and in vitro micropropagation from shoot tip and leaf (Uddin et al., 2006). Hence, study was carried out to establish a suitable protocol for in vitro propagation of S. rebaudiana Bertoni that can be further up-scaled for mass propagation of stevia seedlings. The established Standard Operating Procedure (SOP) will ensure rapid and efficient production of stevia tissue culture seedlings for continuous supply of planting materials for commercial stevia plantations in Malaysia. Preparation of growth medium, multiplication of shoots, rooting of plant lets and hardening of ex-vitro rooted plant lets is discussed in this paper. (author)

Korrelasjon mellom core styrke, core stabilitet og utholdende styrke i core

OpenAIRE

Berg-Olsen, Andrea Marie; Fugelsøy, Eivor; Maurstad, Ann-Louise

2010-01-01

Formålet med studien var å se hvilke korrelasjon det er mellom core styrke, core stabilitet og utholdende styrke i core. Testingen bestod av tre hoveddeler hvor vi testet core styrke, core stabilitet og utholdende styrke i core. Innenfor core styrke og utholdende styrke i core ble tre ulike tester utført. Ved måling av core stabilitet ble det gjennomført kun en test. I core styrke ble isometrisk abdominal fleksjon, isometrisk rygg ekstensjon og isometrisk lateral fleksjon testet. Sit-ups p...

A widefield fluorescence microscope with a linear image sensor for image cytometry of biospecimens: Considerations for image quality optimization

Energy Technology Data Exchange (ETDEWEB)

Hutcheson, Joshua A.; Majid, Aneeka A.; Powless, Amy J.; Muldoon, Timothy J., E-mail: tmuldoon@uark.edu [Department of Biomedical Engineering, University of Arkansas, 120 Engineering Hall, Fayetteville, Arkansas 72701 (United States)

2015-09-15

Linear image sensors have been widely used in numerous research and industry applications to provide continuous imaging of moving objects. Here, we present a widefield fluorescence microscope with a linear image sensor used to image translating objects for image cytometry. First, a calibration curve was characterized for a custom microfluidic chamber over a span of volumetric pump rates. Image data were also acquired using 15 μm fluorescent polystyrene spheres on a slide with a motorized translation stage in order to match linear translation speed with line exposure periods to preserve the image aspect ratio. Aspect ratios were then calculated after imaging to ensure quality control of image data. Fluorescent beads were imaged in suspension flowing through the microfluidics chamber being pumped by a mechanical syringe pump at 16 μl min{sup −1} with a line exposure period of 150 μs. The line period was selected to acquire images of fluorescent beads with a 40 dB signal-to-background ratio. A motorized translation stage was then used to transport conventional glass slides of stained cellular biospecimens. Whole blood collected from healthy volunteers was stained with 0.02% (w/v) proflavine hemisulfate was imaged to highlight leukocyte morphology with a 1.56 mm × 1.28 mm field of view (1540 ms total acquisition time). Oral squamous cells were also collected from healthy volunteers and stained with 0.01% (w/v) proflavine hemisulfate to demonstrate quantifiable subcellular features and an average nuclear to cytoplasmic ratio of 0.03 (n = 75), with a resolution of 0.31 μm pixels{sup −1}.

Environmental Sciences Division Toxicology Laboratory standard operating procedures

International Nuclear Information System (INIS)

Kszos, L.A.; Stewart, A.J.; Wicker, L.F.; Logsdon, G.M.

1989-09-01

This document was developed to provide the personnel working in the Environmental Sciences Division's Toxicology Laboratory with documented methods for conducting toxicity tests. The document consists of two parts. The first part includes the standard operating procedures (SOPs) that are used by the laboratory in conducting toxicity tests. The second part includes reference procedures from the US Environmental Protection Agency document entitled Short-Term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms, upon which the Toxicology Laboratory's SOPs are based. Five of the SOPs include procedures for preparing Ceriodaphnia survival and reproduction test. These SOPs include procedures for preparing Ceriodaphnia food (SOP-3), maintaining Ceriodaphnia cultures (SOP-4), conducting the toxicity test (SOP-13), analyzing the test data (SOP-13), and conducting a Ceriodaphnia reference test (SOP-15). Five additional SOPs relate specifically to the fathead minnow (Pimephales promelas) larval survival and growth test: methods for preparing fathead minnow larvae food (SOP-5), maintaining fathead minnow cultures (SOP-6), conducting the toxicity test (SOP-9), analyzing the test data (SOP-12), and conducting a fathead minnow reference test (DOP-14). The six remaining SOPs describe methods that are used with either or both tests: preparation of control/dilution water (SOP-1), washing of glassware (SOP-2), collection and handling of samples (SOP-7), preparation of samples (SOP-8), performance of chemical analyses (SOP-11), and data logging and care of technical notebooks (SOP-16)

FINANCIAL INDICATORS FOR THE IMPLEMENTATION OF AN EUROPEAN FUNDED INVESTMENT PROJECT UNDER SOP IEC PROGRAMME – CASE STUDY OF A ROMANIAN SME

Directory of Open Access Journals (Sweden)

Droj Laurentiu

2010-07-01

Full Text Available The European Integration came with new challenges for the Romanian enterprises especially for the SMEs, the opportunities arising from operating on the European Single Market and the possibility for accession of European Regional Development Funds. The main programme designed to offer access for small, medium and large Romanian enterprises to European funding is the Sectorial Operational Programme “Increase of Economic Competitiveness”- SOP IEC. This paper will analyze the area of intervention “D1.1. Productive and environment friendly investments and preparation for market competition in which Romanian SMEs” are competing to access European funding in order to develop their activities or to extend them into new ones. One of the main challenges for these SMEs is to generate, fulfil and to respect the financial indicators of the programme, which are part of the financial analysis of the project.

rpoS-Regulated core genes involved in the competitive fitness of Salmonella enterica Serovar Kentucky in the intestines of chickens.

Science.gov (United States)

Cheng, Ying; Pedroso, Adriana Ayres; Porwollik, Steffen; McClelland, Michael; Lee, Margie D; Kwan, Tiffany; Zamperini, Katherine; Soni, Vivek; Sellers, Holly S; Russell, Scott M; Maurer, John J

2015-01-01

Salmonella enterica serovar Kentucky has become the most frequently isolated serovar from poultry in the United States over the past decade. Despite its prevalence in poultry, it causes few human illnesses in the United States. The dominance of S. Kentucky in poultry does not appear to be due to single introduction of a clonal strain, and its reduced virulence appears to correlate with the absence of virulence genes grvA, sseI, sopE, and sodC1. S. Kentucky's prevalence in poultry is possibly attributable to its metabolic adaptation to the chicken cecum. While there were no difference in the growth rate of S. Kentucky and S. Typhimurium grown microaerophilically in cecal contents, S. Kentucky persisted longer when chickens were coinfected with S. Typhimurium. The in vivo advantage that S. Kentucky has over S. Typhimurium appears to be due to differential regulation of core Salmonella genes via the stationary-phase sigma factor rpoS. Microarray analysis of Salmonella grown in cecal contents in vitro identified several metabolic genes and motility and adherence genes that are differentially activated in S. Kentucky. The contributions of four of these operons (mgl, prp, nar, and csg) to Salmonella colonization in chickens were assessed. Deletion of mgl and csg reduced S. Kentucky persistence in competition studies in chickens infected with wild-type or mutant strains. Subtle mutations affecting differential regulation of core Salmonella genes appear to be important in Salmonella's adaptation to its animal host and especially for S. Kentucky's emergence as the dominant serovar in poultry. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

A designated centre for people with disabilities operated by St Catherine's Association Limited, Wicklow

LENUS (Irish Health Repository)

Knodler, Leigh A

2009-11-01

The Salmonella type III effector, SopB, is an inositol polyphosphate phosphatase that modulates host cell phospholipids at the plasma membrane and the nascent Salmonella-containing vacuole (SCV). Translocated SopB persists for many hours after infection and is ubiquitinated but the significance of this covalent modification has not been investigated. Here we identify by mass spectrometry six lysine residues of SopB that are mono-ubiquitinated. Substitution of these six lysine residues with arginine, SopB-K(6)R, almost completely eliminated SopB ubiquitination. We found that ubiquitination does not affect SopB stability or membrane association, or SopB-dependent events in SCV biogenesis. However, two spatially and temporally distinct events are dependent on ubiquitination, downregulation of SopB activity at the plasma membrane and prolonged retention of SopB on the SCV. Activation of the mammalian pro-survival kinase Akt\\/PKB, a downstream target of SopB, was intensified and prolonged after infection with the SopB-K(6)R mutant. At later times, fewer SCV were decorated with SopB-K(6)R compared with SopB. Instead SopB-K(6)R was present as discrete vesicles spread diffusely throughout the cell. Altogether, our data show that ubiquitination of SopB is not related to its intracellular stability but rather regulates its enzymatic activity at the plasma membrane and intracellular localization.

Reproducibility in light microscopy: Maintenance, standards and SOPs.

Science.gov (United States)

Deagle, Rebecca C; Wee, Tse-Luen Erika; Brown, Claire M

2017-08-01

Light microscopy has grown to be a valuable asset in both the physical and life sciences. It is a highly quantitative method available in individual research laboratories and often centralized in core facilities. However, although quantitative microscopy is becoming a customary tool in research, it is rarely standardized. To achieve accurate quantitative microscopy data and reproducible results, three levels of standardization must be considered: (1) aspects of the microscope, (2) the sample, and (3) the detector. The accuracy of the data is only as reliable as the imaging system itself, thereby imposing the need for routine standard performance testing. Depending on the task some maintenance procedures should be performed once a month, some before each imaging session, while others conducted annually. This text should be implemented as a resource for researchers to integrate with their own standard operating procedures to ensure the highest quality quantitative microscopy data. Copyright © 2017. Published by Elsevier Ltd.

NCI’s Cooperative Human Tissue Network

Science.gov (United States)

Quality biospecimens are a foundational resource for cancer research. One of NCI’s longest running biospecimen programs is the Cooperative Human Tissue Network, a resource mainly for basic discovery and early translational research.

Core Hunter 3: flexible core subset selection.

Science.gov (United States)

De Beukelaer, Herman; Davenport, Guy F; Fack, Veerle

2018-05-31

Core collections provide genebank curators and plant breeders a way to reduce size of their collections and populations, while minimizing impact on genetic diversity and allele frequency. Many methods have been proposed to generate core collections, often using distance metrics to quantify the similarity of two accessions, based on genetic marker data or phenotypic traits. Core Hunter is a multi-purpose core subset selection tool that uses local search algorithms to generate subsets relying on one or more metrics, including several distance metrics and allelic richness. In version 3 of Core Hunter (CH3) we have incorporated two new, improved methods for summarizing distances to quantify diversity or representativeness of the core collection. A comparison of CH3 and Core Hunter 2 (CH2) showed that these new metrics can be effectively optimized with less complex algorithms, as compared to those used in CH2. CH3 is more effective at maximizing the improved diversity metric than CH2, still ensures a high average and minimum distance, and is faster for large datasets. Using CH3, a simple stochastic hill-climber is able to find highly diverse core collections, and the more advanced parallel tempering algorithm further increases the quality of the core and further reduces variability across independent samples. We also evaluate the ability of CH3 to simultaneously maximize diversity, and either representativeness or allelic richness, and compare the results with those of the GDOpt and SimEli methods. CH3 can sample equally representative cores as GDOpt, which was specifically designed for this purpose, and is able to construct cores that are simultaneously more diverse, and either are more representative or have higher allelic richness, than those obtained by SimEli. In version 3, Core Hunter has been updated to include two new core subset selection metrics that construct cores for representativeness or diversity, with improved performance. It combines and outperforms the

[Quality assurance and quality management in intensive care].

Science.gov (United States)

Notz, K; Dubb, R; Kaltwasser, A; Hermes, C; Pfeffer, S

2015-11-01

Treatment success in hospitals, particularly in intensive care units, is directly tied to quality of structure, process, and outcomes. Technological and medical advancements lead to ever more complex treatment situations with highly specialized tasks in intensive care nursing. Quality criteria that can be used to describe and correctly measure those highly complex multiprofessional situations have only been recently developed and put into practice.In this article, it will be shown how quality in multiprofessional teams can be definded and assessed in daily clinical practice. Core aspects are the choice of a nursing theory, quality assurance measures, and quality management. One possible option of quality assurance is the use of standard operating procedures (SOPs). Quality can ultimately only be achieved if professional groups think beyond their boundaries, minimize errors, and establish and live out instructions and SOPs.

Clinical trial participant characteristics and saliva and DNA metrics

Directory of Open Access Journals (Sweden)

Richards Julie

2009-10-01

Full Text Available Abstract Background Clinical trial and epidemiological studies need high quality biospecimens from a representative sample of participants to investigate genetic influences on treatment response and disease. Obtaining blood biospecimens presents logistical and financial challenges. As a result, saliva biospecimen collection is becoming more frequent because of the ease of collection and lower cost. This article describes an assessment of saliva biospecimen samples collected through the mail, trial participant demographic and behavioral characteristics, and their association with saliva and DNA quantity and quality. Methods Saliva biospecimens were collected using the Oragene® DNA Self-Collection Kits from participants in a National Cancer Institute funded smoking cessation trial. Saliva biospecimens from 565 individuals were visually inspected for clarity prior to and after DNA extraction. DNA samples were then quantified by UV absorbance, PicoGreen®, and qPCR. Genotyping was performed on 11 SNPs using TaqMan® SNP assays and two VNTR assays. Univariate, correlation, and analysis of variance analyses were conducted to observe the relationship between saliva sample and participant characteristics. Results The biospecimen kit return rate was 58.5% among those invited to participate (n = 967 and 47.1% among all possible COMPASS participants (n = 1202. Significant gender differences were observed with males providing larger saliva volume (4.7 vs. 4.5 ml, p = 0.019, samples that were more likely to be judged as cloudy (39.5% vs. 24.9%, p 0.21, P Conclusion Findings from this study show that demographic and behavioral characteristics of smoking cessation trial participants have significant associations with saliva and DNA metrics, but not with the performance of TaqMan® SNP or VNTR genotyping assays. Trial registration COMPASS; registered as NCT00301145 at clinicaltrials.gov.

Analysis Of Core Management For The Transition Cores Of RSG-GAS Reactor To Full-Silicide Core

International Nuclear Information System (INIS)

Malem Sembiring, Tagor; Suparlina, Lily; Tukiran

2001-01-01

The core conversion of RSG-GAS reactor from oxide to silicide core with meat density of 2.96 g U/cc is still doing. At the end of 2000, the reactor has been operated for 3 transition cores which is the mixed core of oxide-silicide. Based on previous work, the calculated core parameter for the cores were obtained and it is needed 10 transition cores to achieve a full-silicide core. The objective of this work is to acquire the effect of the increment of the number of silicide fuel on the core parameters such as excess reactivity and shutdown margin. The measurement of the core parameters was carried out using the method of compensation of couple control rods. The experiment shows that the excess reactivity trends lower with the increment of the number of silicide fuel in the core. However, the shutdown margin is not change with the increment of the number of silicide fuel. Therefore, the transition cores can be operated safety to a full-silicide core

Core-to-core uniformity improvement in multi-core fiber Bragg gratings

Science.gov (United States)

Lindley, Emma; Min, Seong-Sik; Leon-Saval, Sergio; Cvetojevic, Nick; Jovanovic, Nemanja; Bland-Hawthorn, Joss; Lawrence, Jon; Gris-Sanchez, Itandehui; Birks, Tim; Haynes, Roger; Haynes, Dionne

2014-07-01

Multi-core fiber Bragg gratings (MCFBGs) will be a valuable tool not only in communications but also various astronomical, sensing and industry applications. In this paper we address some of the technical challenges of fabricating effective multi-core gratings by simulating improvements to the writing method. These methods allow a system designed for inscribing single-core fibers to cope with MCFBG fabrication with only minor, passive changes to the writing process. Using a capillary tube that was polished on one side, the field entering the fiber was flattened which improved the coverage and uniformity of all cores.

The NASA Ames Life Sciences Data Archive: Biobanking for the Final Frontier

Science.gov (United States)

Rask, Jon; Chakravarty, Kaushik; French, Alison J.; Choi, Sungshin; Stewart, Helen J.

2017-01-01

The NASA Ames Institutional Scientific Collection involves the Ames Life Sciences Data Archive (ALSDA) and a biospecimen repository, which are responsible for archiving information and non-human biospecimens collected from spaceflight and matching ground control experiments. The ALSDA also manages a biospecimen sharing program, performs curation and long-term storage operations, and facilitates distribution of biospecimens for research purposes via a public website (https:lsda.jsc.nasa.gov). As part of our best practices, a tissue viability testing plan has been developed for the repository, which will assess the quality of samples subjected to long-term storage. We expect that the test results will confirm usability of the samples, enable broader science community interest, and verify operational efficiency of the archives. This work will also support NASA open science initiatives and guides development of NASA directives and policy for curation of biological collections.

Coupling between core and cladding modes in a helical core fiber with large core offset

International Nuclear Information System (INIS)

Napiorkowski, Maciej; Urbanczyk, Waclaw

2016-01-01

We analyzed the effect of resonant coupling between core and cladding modes in a helical core fiber with large core offset using the fully vectorial method based on the transformation optics formalism. Our study revealed that the resonant couplings to lower order cladding modes predicted by perturbative methods and observed experimentally in fibers with small core offsets are in fact prohibited for larger core offsets. This effect is related to the lack of phase matching caused by elongation of the optical path of the fundamental modes in the helical core. Moreover, strong couplings to the cladding modes of the azimuthal modal number much higher than predicted by perturbative methods may be observed for large core offsets, as the core offset introduces higher order angular harmonics in the field distribution of the fundamental modes. Finally, in contrast to previous studies, we demonstrate the existence of spectrally broad polarization sensitive couplings to the cladding modes suggesting that helical core fibers with large core offsets may be used as broadband circular polarizers. (paper)

Evaluation of In-Core Fuel Management for the Transition Cores of RSG-GAS Reactor to Full-Silicide Core

International Nuclear Information System (INIS)

S, Tukiran; MS, Tagor; P, Surian

2003-01-01

The core conversion of RSG-GAS reactor from oxide to silicide core with meat density of 2.96 gU/cc has been done. The core-of RSG-GAS reactor has been operated full core of silicide fuels which is started with the mixed core of oxide-silicide start from core 36. Based on previous work, the calculated core parameter for the cores were obtained and it is needed 9 transition cores (core 36 - 44) to achieve a full-silicide core (core 45). The objective of this work is to acquire the effect of the increment of the number of silicide fuel on the core parameters. Conversion core was achieved by transition cores mixed oxide-silicide fuels. Each transition core is calculated and measured core parameter such as, excess reactivity and shutdown margin. Calculation done by Batan-EQUIL-2D code and measurement of the core parameters was carried out using the method of compensation of couple control rods. The results of calculation and experiment shows that the excess reactivity trends lower with the increment of the number of silicide fuel in the core. However, the shutdown margin is not change with the increment of the number of silicide fuel. Therefore, the transition cores can be operated safely to a full-silicide core

Earth's inner core: Innermost inner core or hemispherical variations?

NARCIS (Netherlands)

Lythgoe, K. H.; Deuss, A.|info:eu-repo/dai/nl/412396610; Rudge, J. F.; Neufeld, J. A.

2014-01-01

The structure of Earth's deep inner core has important implications for core evolution, since it is thought to be related to the early stages of core formation. Previous studies have suggested that there exists an innermost inner core with distinct anisotropy relative to the rest of the inner core.

Dependence of Core and Extended Flux on Core Dominance ...

Indian Academy of Sciences (India)

Abstract. Based on two extragalactic radio source samples, the core dominance parameter is calculated, and the correlations between the core/extended flux density and core dominance parameter are investi- gated. When the core dominance parameter is lower than unity, it is linearly correlated with the core flux density, ...

On-line core monitoring with CORE MASTER / PRESTO

International Nuclear Information System (INIS)

Lindahl, S.O.; Borresen, S.; Ovrum, S.

1986-01-01

Advanced calculational tools are instrumental in improving reactor plant capacity factors and fuel utilization. The computer code package CORE MASTER is an integrated system designed to achieve this objective. The system covers all main activities in the area of in-core fuel management for boiling water reactors; design, operation support, and on-line core monitoring. CORE MASTER operates on a common data base, which defines the reactor and documents the operating history of the core and of all fuel bundles ever used

Differences in preferences for models of consent for biobanks between Black and White women.

Science.gov (United States)

Brown, Katherine M; Drake, Bettina F; Gehlert, Sarah; Wolf, Leslie E; DuBois, James; Seo, Joann; Woodward, Krista; Perkins, Hannah; Goodman, Melody S; Kaphingst, Kimberly A

2016-01-01

Biobanks are essential resources, and participation by individuals from diverse groups is needed. Various models of consent have been proposed for secondary research use of biospecimens, differing in level of donor control and information received. Data are needed regarding participant preferences for models of consent, particularly among minorities. We conducted qualitative semi-structured interviews with 60 women to examine their attitudes about different models of consent. Recruitment was stratified by race (Black/White) and prior biobank participation (yes/no). Two coders independently coded interview transcripts. Qualitative thematic analysis was conducted using NVivo 10. The majority of Black and White participants preferred "broad" consent (i.e., blanket permission for secondary research use of biospecimens), and the second most preferred model for both groups was "study-specific" consent (i.e., consent for each future research study). The qualitative analysis showed that participants selected their most preferred model for 3 major reasons: having enough information, having control over their sample, and being asked for permission. Least preferred was notice model (i.e., participants notified that biospecimens may be used in future research). Attitudes toward models of consent differed somewhat by race and prior biobank participation. Participants preferred models of consent for secondary research use of biospecimens that provided them with both specific and general information, control over their biospecimens, and asked them to give permission for use. Our findings suggest that it will be important for researchers to provide information about future uses of biospecimens to the extent possible and have an explicit permission step for secondary research use.

Restraint system for core elements of a reactor core

International Nuclear Information System (INIS)

Class, G.

1975-01-01

In a nuclear reactor, a core element bundle formed of a plurality of side-by-side arranged core elements is surrounded by restraining elements that exert a radially inwardly directly restraining force generating friction forces between the core elements in a restraining plane that is transverse to the core element axes. The adjoining core elements are in rolling contact with one another in the restraining plane by virtue of rolling-type bearing elements supported in the core elements. (Official Gazette)

Should total landings be used to correct estimated catch in numbers or mean-weight-at-age?

DEFF Research Database (Denmark)

Lewy, Peter; Lassen, H.

1997-01-01

Many ICES fish stock assessment working groups have practised Sum Of Products, SOP, correction. This correction stems from a comparison of total weights of the known landings and the SOP over age of catch in number and mean weight-at-age, which ideally should be identical. In case of SOP...... discrepancies some countries correct catch in numbers while others correct mean weight-at-age by a common factor, the ratio between landing and SOP. The paper shows that for three sampling schemes the SOP corrections are statistically incorrect and should not be made since the SOP is an unbiased estimate...... of the total landings. Calculation of the bias of estimated catch in numbers and mean weight-at-age shows that SOP corrections of either of these estimates may increase the bias. Furthermore, for five demersal and one pelagic North Sea species it is shown that SOP discrepancies greater than 2% from...

Effects of soya oligosaccharides and soya oligopeptides on lipid metabolism in hyperlipidaemic rats.

Science.gov (United States)

Xie, Shali; Zhu, Jundong; Zhang, Yanqi; Shi, Kai; Shi, Yuangang; Ma, Xiao

2012-08-01

In the present study, we aimed to examine the effects of soya oligosaccharides (SOS) and soya oligopeptides (SOP) on blood lipid levels, release of vasoactive substances, antioxidant activity and faecal bile acid (FBA) excretion in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were evenly divided into five groups according to diets as follows: regular diet (control), HFD, HFD enriched with 2 % of SOS (SOS), HFD enriched with 3 % of SOP (SOP) and HFD enriched with 2 % SOS and 3 % SOP (SOSP). The results showed that SOS and SOP significantly reduced plasma total cholesterol, LDL-cholesterol and TAG, whereas HDL-cholesterol concentration was significantly increased. Furthermore, SOS and SOP reduced plasma apoB, apoE and the apoB:apoAI ratio, whereas apoAI was significantly increased. Moreover, SOS and SOP also reduced plasma thromboxane A₂ (TXA₂) and the TXA₂:prostacyclin (PGI₂) ratio, whereas plasma PGI₂ and nitric oxide were significantly increased. In addition, SOS and SOP significantly reduced serum and liver malondialdehyde concentrations and increased FBA excretion. However, we did not observe obvious influences of SOS and SOP on superoxide dismutase activities in the liver of HFD-fed rats. The combination of 2 % SOS and 3 % SOP showed a more marked effect than SOS or SOP alone in improving the lipid profile, release of vasoactive substances and increasing FBA excretion (P < 0.05). In summary, SOS and SOP might help prevent atherosclerosis through improving abnormal blood lipid levels, regulating vasoactive substances and protecting against oxidative stress.

Prevalence and trend in the use of hospital-based standing orders programs for influenza and pneumococcal vaccination.

Science.gov (United States)

Pentakota, Sri Ram; Halperin, William

2007-08-01

In 2002, federal regulations authorized the use of standing orders programs (SOPs) for promoting influenza and pneumococcal vaccination. In 2003, the New Jersey Hospital Association conducted a demonstration project illustrating the efficacy of SOPs, and the state health department informed healthcare facilities of their benefits. We describe the prevalence of reported use of SOPs in New Jersey hospitals in 2003 and 2005 and identify hospital characteristics associated with the use of SOPs. A survey was mailed to the directors of infection control at 117 New Jersey hospitals during the period from January to May 2005 (response rate, 90.6%). Data on hospital characteristics were obtained from hospital directories and online resources. The prevalence of use of SOPs for influenza vaccination was 50% (95% confidence interval [CI], 40.1%-59.9%) in 2003, and it increased to 78.3% (95% CI, 69.2%-85.7%) in 2005. The prevalence of SOP use for pneumococcal vaccination was similar. In 2005, the reported rate of use of SOPs for inpatients (influenza vaccination, 76.4%; pneumococcal vaccination, 75.5%) was significantly higher than that for outpatients (influenza vaccination, 9.4%; pneumococcal vaccination, 8.5%). Prevalence ratios for SOP use comparing acute care and non-acute care hospitals were 1.71 (95% CI, 1.2-2.5) for influenza vaccination SOPs and 1.8 for (95% CI, 1.2-2.7) pneumococcal vaccination SOPs. Acute care hospitals with a ratio of admissions to total beds greater than 36.7 reported greater use of SOPs for pneumococcal vaccination, compared with those that had a ratio of less than 36.7. The increase in the prevalence of reported use of SOPs among New Jersey hospitals in 2005, compared with 2003, was contemporaneous with SOP-related actions taken by the federal government, the state government, and the New Jersey Hospital Association. Opportunities persist for increased use of SOPs among non-acute care hospitals and for outpatients.

Methodological Study to Develop Standard Operational Protocol on Oral Drug Administration for Children.

Science.gov (United States)

Bijarania, Sunil Kumar; Saini, Sushma Kumari; Verma, Sanjay; Kaur, Sukhwinder

2017-05-01

To develop standard operational protocol (SOP) on oral drug administration and checklist to assess the implementation of the developed SOP. In this prospective methodological study, SOPs were developed in five phases. In the first phase, the preliminary draft of SOPs and checklists were prepared based on literature review, assessment of current practices and focus group discussion (FGD) with bedside working nurses. In the second phase, content validity was checked with the help of Delphi technique (12 experts). Total four drafts were prepared in stages and necessary modifications were made as per suggestions after each Delphi round. Fourth Delphi round was performed after conducting a pilot study. In the fourth phase, all bedside nurses were trained as per SOPs and asked to practice accordingly and observation of thirty oral drug administrations in children was done to check reliability of checklists for implementation of SOPs. In Phase-V, 7 FGDs were conducted with bedside nurses to assess the effectiveness of SOPs. The Content Validity Index (CVI) of SOP and checklists was 99.77%. Overall standardized Cronbach's alpha was calculated as 0.94. All the nurses felt that the SOP is useful. Valid and feasible SOP for drug administration to children through oral route along with valid and reliable checklist were developed. It is recommended to use this document for drug administration to children.

Core lifter

Energy Technology Data Exchange (ETDEWEB)

Pavlov, N G; Edel' man, Ya A

1981-02-15

A core lifter is suggested which contains a housing, core-clamping elements installed in the housing depressions in the form of semirings with projections on the outer surface restricting the rotation of the semirings in the housing depressions. In order to improve the strength and reliability of the core lifter, the semirings have a variable transverse section formed from the outside by the surface of the rotation body of the inner arc of the semiring aroung the rotation axis and from the inner a cylindrical surface which is concentric to the outer arc of the semiring. The core-clamping elements made in this manner have the possibility of freely rotating in the housing depressions under their own weight and from contact with the core sample. These semirings do not have weakened sections, have sufficient strength, are inserted into the limited ring section of the housing of the core lifter without reduction in its through opening and this improve the reliability of the core lifter in operation.

Side core lifter

Energy Technology Data Exchange (ETDEWEB)

Edelman, Ya A

1982-01-01

A side core lifter is proposed which contains a housing with guide slits and a removable core lifter with side projections on the support section connected to the core receiver. In order to preserve the structure of the rock in the core sample by means of guaranteeing rectilinear movement of the core lifter in the rock, the support and core receiver sections are hinged. The device is equipped with a spring for angular shift in the core-reception part.

Core mechanics and configuration behavior of advanced LMFBR core restraint concepts

International Nuclear Information System (INIS)

Fox, J.N.; Wei, B.C.

1978-02-01

Core restraint systems in LMFBRs maintain control of core mechanics and configuration behavior. Core restraint design is complex due to the close spacing between adjacent components, flux and temperature gradients, and irradiation-induced material property effects. Since the core assemblies interact with each other and transmit loads directly to the core restraint structural members, the core assemblies themselves are an integral part of the core restraint system. This paper presents an assessment of several advanced core restraint system and core assembly concepts relative to the expected performance of currently accepted designs. A recommended order for the development of the advanced concepts is also presented

Chemical characterisation of iron in dust and biomass burning aerosols during AMMA-SOP0/DABEX: implication for iron solubility

Directory of Open Access Journals (Sweden)

R. Paris

2010-05-01

Full Text Available The chemical composition and the soluble fraction were determined in aerosol samples collected during flights of AMMA-SOP0/DABEX campaign, which were conducted in the West African Sahel during dry season (2006. Two aerosol types are encountered in this period: dust particles (DUST and biomass burning aerosol (BB. Chemical analysis and microscope observations showed that the iron (Fe found in BB samples mainly originates from dust particles mostly internally mixed in the biomass burning layer. Chemical analyses of samples showed that the Fe solubility is lower in African dust samples than in biomass burning aerosols. Our data provide a first idea of the variability of iron dust solubility in the source region (0.1% and 3.4%. We found a relationship between iron solubility/clay content/source which partly confirms that the variability of iron solubility in this source region is related to the character and origin of the aerosols themselves. In the biomass burning samples, no relationship were found between Fe solubility and either the concentrations of acidic species (SO₄²⁻, NO₃⁻ or oxalate or the content of carbon (TC, OC, BC. Therefore, we were unable to determine what processes are involved in this increase of iron solubility. In terms of supply of soluble Fe to oceanic ecosystems on a global scale, the higher solubility observed for Fe in biomass burning could imply an indirect source of Fe to marine ecosystems. But these aerosols are probably not significant because the Sahara is easily the dominant source of Fe to the Atlantic Ocean.

How cores grow by pebble accretion. I. Direct core growth

Science.gov (United States)

Brouwers, M. G.; Vazan, A.; Ormel, C. W.

2018-03-01

Context. Planet formation by pebble accretion is an alternative to planetesimal-driven core accretion. In this scenario, planets grow by the accretion of cm- to m-sized pebbles instead of km-sized planetesimals. One of the main differences with planetesimal-driven core accretion is the increased thermal ablation experienced by pebbles. This can provide early enrichment to the planet's envelope, which influences its subsequent evolution and changes the process of core growth. Aims: We aim to predict core masses and envelope compositions of planets that form by pebble accretion and compare mass deposition of pebbles to planetesimals. Specifically, we calculate the core mass where pebbles completely evaporate and are absorbed before reaching the core, which signifies the end of direct core growth. Methods: We model the early growth of a protoplanet by calculating the structure of its envelope, taking into account the fate of impacting pebbles or planetesimals. The region where high-Z material can exist in vapor form is determined by the temperature-dependent vapor pressure. We include enrichment effects by locally modifying the mean molecular weight of the envelope. Results: In the pebble case, three phases of core growth can be identified. In the first phase (Mcore mixes outwards, slowing core growth. In the third phase (Mcore > 0.5M⊕), the high-Z inner region expands outwards, absorbing an increasing fraction of the ablated material as vapor. Rainout ends before the core mass reaches 0.6 M⊕, terminating direct core growth. In the case of icy H2O pebbles, this happens before 0.1 M⊕. Conclusions: Our results indicate that pebble accretion can directly form rocky cores up to only 0.6 M⊕, and is unable to form similarly sized icy cores. Subsequent core growth can proceed indirectly when the planet cools, provided it is able to retain its high-Z material.

Establishment of a cervical cancer bio-bank for the Chinese population: from project-based sample collection to routine management.

Science.gov (United States)

Yang, Ru; Li, Xiong; Zhou, Hang; Jia, Yao; Zhou, Jin; Huang, Kecheng; Tang, Fangxu; Hu, Ting; Shen, Jian; Chen, Zhilan; Wang, Shaoshuai; Sun, Haiying; Guo, Lili; Wang, Lin; Wang, Hui; Ma, Ding; Li, Shuang

2015-08-01

There is an increasing need for the establishment of a cervical cancer bio-bank that will facilitate both clinical and basic research. The cervical cancer bio-bank was first established in January 1999 and included two stages. First, a GWAS-based sample collection was conducted with special emphasis on the diagnosis and the retrieval of the corresponding bio-specimens, especially blood samples. Second, clinical data and their corresponding bio-specimens were routinely collected and handled. Notably, these bio-specimens also included samples from Wufeng Tujia Autonomous County, which has the highest incidence of cervical cancer in China. The specimens were collected from patients with cervical cancer and those with cervical intraepithelial neoplasia, while the control samples were collected from normal individuals. With special emphasis on clinical data and blood samples for the GWAS analysis, the collection of other bio-specimens was slow, and the pairing of specimens and clinical data was poor during the first stage. However, in the second stage, the pairing of the clinical data and its corresponding bio-specimens improved. At present, the samples procured and preserved in the bio-bank cover most regions of China and different ethnic groups for both the normal controls and cervical cancer patients of different pathological categories. This bio-bank of cervical cancer specimens from the Chinese population will greatly promote the studies of cervical cancer in China.

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GALEN platform. The Galenda project.

Science.gov (United States)

Bousquet, P-J; Demoly, P; Romano, A; Aberer, W; Bircher, A; Blanca, M; Brockow, K; Pichler, W; Torres, M J; Terreehorst, I; Arnoux, B; Atanaskovic-Markovic, M; Barbaud, A; Bijl, A; Bonadonna, P; Burney, P G; Caimmi, S; Canonica, G W; Cernadas, J; Dahlen, B; Daures, J-P; Fernandez, J; Gomes, E; Gueant, J-L; Kowalski, M L; Kvedariene, V; Mertes, P-M; Martins, P; Nizankowska-Mogilnicka, E; Papadopoulos, N; Ponvert, C; Pirmohamed, M; Ring, J; Salapatas, M; Sanz, M L; Szczeklik, A; Van Ganse, E; De Weck, A L; Zuberbier, T; Merk, H F; Sachs, B; Sidoroff, A

2009-02-01

Nonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs. Spontaneous reporting makes up the core data-generating system of pharmacovigilance, but there is a large under-estimation of allergy/hypersensitivity drug reactions. A specific database is therefore required for drug allergy and hypersensitivity using standard operating procedures (SOPs), as the diagnosis of drug allergy/hypersensitivity is difficult and current pharmacovigilance algorithms are insufficient. Although difficult, the diagnosis of drug allergy/hypersensitivity has been standardized by the European Network for Drug Allergy (ENDA) under the aegis of the European Academy of Allergology and Clinical Immunology and SOPs have been published. Based on ENDA and Global Allergy and Asthma European Network (GA(2)LEN, EU Framework Programme 6) SOPs, a Drug Allergy and Hypersensitivity Database (DAHD((R))) has been established under FileMaker((R)) Pro 9. It is already available online in many different languages and can be accessed using a personal login. GA(2)LEN is a European network of 27 partners (16 countries) and 59 collaborating centres (26 countries), which can coordinate and implement the DAHD across Europe. The GA(2)LEN-ENDA-DAHD platform interacting with a pharmacovigilance network appears to be of great interest for the reporting of allergy/hypersensitivity ADRs in conjunction with other pharmacovigilance instruments.

The importance of production standard operating procedure in a family business company

Science.gov (United States)

Hongdiyanto, C.

2017-12-01

Plastic industry is a growing sector, therefore UD X which engage in this business has a great potential to grow as well. The problem faced by this family business company is that no standard operating procedure is used and it lead to problem in the quality and quantity produced. This research is aim to create a production standard operating procedure for UD X. Semistructure interview is used to gather information from respondent to help writer create the SOP. There are four SOP’s created, namely: classifying SOP, sorting SOP, milling SOP and packing SOP. Having SOP will improve the effectiveness of production because employees already know how to work in each stages of production process.

Comparison of facility characteristics between SCTF Core-I and Core-II

International Nuclear Information System (INIS)

Adachi, Hiromichi; Iwamura, Takamichi; Sobajima, Makoto; Ohnuki, Akira; Abe, Yutaka; Murao, Yoshio.

1990-08-01

The Slab Core Test Facility (SCTF) was constructed to investigate two-dimensional thermal-hydraulics in the core and fluid behavior of carryover water out of the core including its feed-back effect to the core behavior mainly during the reflood phase of a large break loss-of-coolant accident (LOCA) of a pressurized water reactor (PWR). Since three simulated cores are used in the SCTF Test Program and the design of these three cores are slightly different one by one, repeatability test is required to justify a direct comparison of data obtained with different cores. In the present report, data of Test S2-13 (Run 618) obtained with SCTF Core-II were compared with those of Test S1-05 (Run 511) obtained with the Core-I, which were performed under the forced-flooding condition. Thermal-hydraulic behaviors in these two tests showed quite similar characteristics of both system behavior and two-dimensional core behaviors. Therefore, the test data obtained from the two cores can be compared directly with each other. After the turnaround of clad temperatures, however, some differences were found in upper plenum water accumulation and resultant two-dimensional core cooling behaviors such as quench front propagation from bottom to top of the core. (author)

Limited consensus around ARM information protection practices ...

African Journals Online (AJOL)

An existing enterprise IP SoP was adapted to ARM through literature analysis and produced a draft ARM SoP. The draft ARM SoP was applied in a rote fashion to a small sample of government-operated archives to identify likely areas of consensus and lack of consensus surrounding the various elements of the SoP.

Cognitive training and selective attention in the aging brain: an electrophysiological study.

Science.gov (United States)

O'Brien, Jennifer L; Edwards, Jerri D; Maxfield, Nathan D; Peronto, Carol L; Williams, Victoria A; Lister, Jennifer J

2013-11-01

Age-related deficits in selective attention are hypothesized to result from decrements in inhibition of task-irrelevant information. Speed of processing (SOP) training is an adaptive cognitive intervention designed to enhance processing speed for attention tasks. The effectiveness of SOP training to improve cognitive and everyday functional performance is well documented. However, underlying mechanisms of these training benefits are unknown. Participants completed a visual search task evaluated using event-related potentials (ERPs) before and after 10 weeks of SOP training or no contact. N2pc and P3b components were evaluated to determine SOP training effects on attentional resource allocation and capacity. Selective attention to a target was enhanced after SOP training compared to no training. N2pc and P3b amplitudes increased after training, reflecting attentional allocation and capacity enhancement, consistent with previous studies demonstrating behavioral improvements in selective attention following SOP training. Changes in ERPs related to attention allocation and capacity following SOP training support the idea that training leads to cognitive enhancement. Specifically, we provide electrophysiological evidence that SOP training may be successful in counteracting age-related declines in selective attention. This study provides important evidence of the underlying mechanisms by which SOP training improves cognitive function in older adults. Published by Elsevier Ireland Ltd.

Temporal Change of Seismic Earth's Inner Core Phases: Inner Core Differential Rotation Or Temporal Change of Inner Core Surface?

Science.gov (United States)

Yao, J.; Tian, D.; Sun, L.; Wen, L.

2017-12-01

Since Song and Richards [1996] first reported seismic evidence for temporal change of PKIKP wave (a compressional wave refracted in the inner core) and proposed inner core differential rotation as its explanation, it has generated enormous interests in the scientific community and the public, and has motivated many studies on the implications of the inner core differential rotation. However, since Wen [2006] reported seismic evidence for temporal change of PKiKP wave (a compressional wave reflected from the inner core boundary) that requires temporal change of inner core surface, both interpretations for the temporal change of inner core phases have existed, i.e., inner core rotation and temporal change of inner core surface. In this study, we discuss the issue of the interpretation of the observed temporal changes of those inner core phases and conclude that inner core differential rotation is not only not required but also in contradiction with three lines of seismic evidence from global repeating earthquakes. Firstly, inner core differential rotation provides an implausible explanation for a disappearing inner core scatterer between a doublet in South Sandwich Islands (SSI), which is located to be beneath northern Brazil based on PKIKP and PKiKP coda waves of the earlier event of the doublet. Secondly, temporal change of PKIKP and its coda waves among a cluster in SSI is inconsistent with the interpretation of inner core differential rotation, with one set of the data requiring inner core rotation and the other requiring non-rotation. Thirdly, it's not reasonable to invoke inner core differential rotation to explain travel time change of PKiKP waves in a very small time scale (several months), which is observed for repeating earthquakes in Middle America subduction zone. On the other hand, temporal change of inner core surface could provide a consistent explanation for all the observed temporal changes of PKIKP and PKiKP and their coda waves. We conclude that

Fe-based nanocrystalline powder cores with ultra-low core loss

Energy Technology Data Exchange (ETDEWEB)

Wang, Xiangyue, E-mail: wangxiangyue1986@163.com [China Iron and Steel Research Institute Group, Beijing 100081 (China); Center of Advanced Technology and Materials Co., Ltd., Beijing 100081 (China); Lu, Zhichao; Lu, Caowei; Li, Deren [China Iron and Steel Research Institute Group, Beijing 100081 (China); Center of Advanced Technology and Materials Co., Ltd., Beijing 100081 (China)

2013-12-15

Melt-spun amorphous Fe{sub 73.5}Cu{sub 1}Nb{sub 3}Si{sub 15.5}B{sub 7} alloy strip was crushed to make flake-shaped fine powders. The passivated powders by phosphoric acid were mixed with organic and inorganic binder, followed by cold compaction to form toroid-shaped bonded powder-metallurgical magnets. The powder cores were heat-treated to crystallize the amorphous structure and to control the nano-grain structure. Well-coated phosphate-oxide insulation layer on the powder surface decreased the the core loss with the insulation of each powder. FeCuNbSiB nanocrystalline alloy powder core prepared from the powder having phosphate-oxide layer exhibits a stable permeability up to high frequency range over 2 MHz. Especially, the core loss could be reduced remarkably. At the other hand, the softened inorganic binder in the annealing process could effectively improve the intensity of powder cores. - Highlights: • Fe-based nanocrystalline powder cores were prepared with low core loss. • Well-coated phosphate-oxide insulation layer on the powder surface decreased the core loss. • Fe-based nanocrystalline powder cores exhibited a stable permeability up to high frequency range over 2 MHz. • The softened inorganic binder in the annealing process could effectively improve the intensity of powder cores.

Benefits analysis of Soft Open Points for electrical distribution network operation

International Nuclear Information System (INIS)

Cao, Wanyu; Wu, Jianzhong; Jenkins, Nick; Wang, Chengshan; Green, Timothy

2016-01-01

Highlights: • An analysis framework was developed to quantify the operational benefits. • The framework considers both network reconfiguration and SOP control. • Benefits were analyzed through both quantitative and sensitivity analysis. - Abstract: Soft Open Points (SOPs) are power electronic devices installed in place of normally-open points in electrical power distribution networks. They are able to provide active power flow control, reactive power compensation and voltage regulation under normal network operating conditions, as well as fast fault isolation and supply restoration under abnormal conditions. A steady state analysis framework was developed to quantify the operational benefits of a distribution network with SOPs under normal network operating conditions. A generic power injection model was developed and used to determine the optimal SOP operation using an improved Powell’s Direct Set method. Physical limits and power losses of the SOP device (based on back to back voltage-source converters) were considered in the model. Distribution network reconfiguration algorithms, with and without SOPs, were developed and used to identify the benefits of using SOPs. Test results on a 33-bus distribution network compared the benefits of using SOPs, traditional network reconfiguration and the combination of both. The results showed that using only one SOP achieved a similar improvement in network operation compared to the case of using network reconfiguration with all branches equipped with remotely controlled switches. A combination of SOP control and network reconfiguration provided the optimal network operation.

In-core Instrument Subcritical Verification (INCISV) - Core Design Verification Method - 358

International Nuclear Information System (INIS)

Prible, M.C.; Heibel, M.D.; Conner, S.L.; Sebastiani, P.J.; Kistler, D.P.

2010-01-01

According to the standard on reload startup physics testing, ANSI/ANS 19.6.1, a plant must verify that the constructed core behaves sufficiently close to the designed core to confirm that the various safety analyses bound the actual behavior of the plant. A large portion of this verification must occur before the reactor operates at power. The INCISV Core Design Verification Method uses the unique characteristics of a Westinghouse Electric Company fixed in-core self powered detector design to perform core design verification after a core reload before power operation. A Vanadium self powered detector that spans the length of the active fuel region is capable of confirming the required core characteristics prior to power ascension; reactivity balance, shutdown margin, temperature coefficient and power distribution. Using a detector element that spans the length of the active fuel region inside the core provides a signal of total integrated flux. Measuring the integrated flux distributions and changes at various rodded conditions and plant temperatures, and comparing them to predicted flux levels, validates all core necessary core design characteristics. INCISV eliminates the dependence on various corrections and assumptions between the ex-core detectors and the core for traditional physics testing programs. This program also eliminates the need for special rod maneuvers which are infrequently performed by plant operators during typical core design verification testing and allows for safer startup activities. (authors)

Waves in the core and mechanical core-mantle interactions

DEFF Research Database (Denmark)

Jault, D.; Finlay, Chris

2015-01-01

This Chapter focuses on time-dependent uid motions in the core interior, which can beconstrained by observations of the Earth's magnetic eld, on timescales which are shortcompared to the magnetic diusion time. This dynamics is strongly inuenced by the Earth's rapid rotation, which rigidies...... the motions in the direction parallel to the Earth'srotation axis. This property accounts for the signicance of the core-mantle topography.In addition, the stiening of the uid in the direction parallel to the rotation axis gives riseto a magnetic diusion layer attached to the core-mantle boundary, which would...... otherwisebe dispersed by Alfven waves. This Chapter complements the descriptions of large-scaleow in the core (8.04), of turbulence in the core (8.06) and of core-mantle interactions(8.12), which can all be found in this volume. We rely on basic magnetohydrodynamictheory, including the derivation...

A core design study for 'zero-sodium-void-worth' cores

International Nuclear Information System (INIS)

Kawashima, Masatoshi; Suzuki, Masao; Hill, R.N.

1992-01-01

Recently, a number of low sodium-void-worth metal-fueled core design concepts have been proposed; to provide for flexibility in transuranic nuclide management strategy, core designs which exhibit a wide range of breeding characteristics have been developed. Two core concepts, a flat annular (transuranic burning) core and an absorber-type parfait (transuranic self-sufficient) core, are selected for this study. In this paper, the excess reactivity management schemes applied in the two designs are investigated in detail. In addition, the transient effect of reactivity insertions on the parfait core design is assessed. The upper and lower core regions in the parfait design are neutronically decoupled; however, the common coolant channel creates thermalhydraulic coupling. This combination of neutronic and thermalhydraulic characteristics leads to unique behavior in anticipated transient overpower events. (author)

k-core covers and the core

NARCIS (Netherlands)

Sanchez-Rodriguez, E.; Borm, Peter; Estevez-Fernandez, A.; Fiestras-Janeiro, G.; Mosquera, M.A.

This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

Organizational Learning, Building and Sustaining Core Competencies: Knowledge Management Initiatives on Inspection and Regulatory Enforcement in BAPETEN Indonesia

International Nuclear Information System (INIS)

Daeng Beta, W. P.; Nurwidi Astuti, Y. H.; Hermawan, A. S.; Syaifulloh, S.

2016-01-01

Full text: Regulatory inspection and law enforcement are among the core competencies of the Indonesia Nuclear Energy Regulatory Agency (BAPETEN). Knowledge management (KM) initiatives are based on strategic planning of BAPETEN. KM in BAPETEN is in its early stage, it is realized since 2015–2016, although its elements have stayed in service for 18 years. Its architecture and performance-information are: to conduct risk based inspection for medical, industrial and research facilities; to plan, monitor and evaluate of effective inspection, including standard operating procedures (SOPs); to utilize inspectors for safety security of radiation sources along with coordination with related stakeholders; to enforce the safety and security facilities report to users; to optimize reliable data communication, processing and information technology (B@LIS); to perform regulatory enforcement along with other related stakeholders. KM processes are performed through the “Socialization, Externalization, Combination, Internalization” (SECI) model. Technical knowledge for inspectors are based on the IAEA–TECDOC–1526 plus supporting knowledge. With KM, innovation products can easily be used, because they are documented, distributed in a KM portal, knowledge is shared through the BAPETEN website, B@LIS database and others. Our challenge is that KM initiatives still need a tremendous effort, not only internally, but also externally, especially in coordination and collaboration. Information access brings about not only positive but also negative impacts. Innovations in regulatory inspection and law enforcement in BAPETEN are planned innovations, sustained, and systematically performed. (author

The Biobank Economic Modeling Tool (BEMT): Online Financial Planning to Facilitate Biobank Sustainability

Science.gov (United States)

Odeh, Hana; Miranda, Lisa; Rao, Abhi; Vaught, Jim; Greenman, Howard; McLean, Jeffrey; Reed, Daniel; Memon, Sarfraz; Fombonne, Benjamin; Guan, Ping

2015-01-01

Background: Biospecimens are essential resources for advancing basic and translational research. However, there are little data available regarding the costs associated with operating a biobank, and few resources to enable their long-term sustainability. To support the research community in this effort, the National Institutes of Health, National Cancer Institute's Biorepositories and Biospecimen Research Branch has developed the Biobank Economic Modeling Tool (BEMT). The tool is accessible at http://biospecimens.cancer.gov/resources/bemt.asp. Methods: To obtain market-based cost information and to inform the development of the tool, a survey was designed and sent to 423 biobank managers and directors across the world. The survey contained questions regarding infrastructure investments, salary costs, funding options, types of biospecimen resources and services offered, as well as biospecimen pricing and service-related costs. Results: A total of 106 responses were received. The data were anonymized, aggregated, and used to create a comprehensive database of cost and pricing information that was integrated into the web-based tool, the BEMT. The BEMT was built to allow the user to input cost and pricing data through a seven-step process to build a cost profile for their biobank, define direct and indirect costs, determine cost recovery fees, perform financial forecasting, and query the anonymized survey data from comparable biobanks. Conclusion: A survey was conducted to obtain a greater understanding of the costs involved in operating a biobank. The anonymized survey data was then used to develop the BEMT, a cost modeling tool for biobanks. Users of the tool will be able to create a cost profile for their biobanks' specimens, products and services, establish pricing, and allocate costs for biospecimens based on percent cost recovered, and perform project-specific cost analyses and financial forecasting. PMID:26697911

The Biobank Economic Modeling Tool (BEMT): Online Financial Planning to Facilitate Biobank Sustainability.

Science.gov (United States)

Odeh, Hana; Miranda, Lisa; Rao, Abhi; Vaught, Jim; Greenman, Howard; McLean, Jeffrey; Reed, Daniel; Memon, Sarfraz; Fombonne, Benjamin; Guan, Ping; Moore, Helen M

2015-12-01

Biospecimens are essential resources for advancing basic and translational research. However, there are little data available regarding the costs associated with operating a biobank, and few resources to enable their long-term sustainability. To support the research community in this effort, the National Institutes of Health, National Cancer Institute's Biorepositories and Biospecimen Research Branch has developed the Biobank Economic Modeling Tool (BEMT). The tool is accessible at http://biospecimens.cancer.gov/resources/bemt.asp. To obtain market-based cost information and to inform the development of the tool, a survey was designed and sent to 423 biobank managers and directors across the world. The survey contained questions regarding infrastructure investments, salary costs, funding options, types of biospecimen resources and services offered, as well as biospecimen pricing and service-related costs. A total of 106 responses were received. The data were anonymized, aggregated, and used to create a comprehensive database of cost and pricing information that was integrated into the web-based tool, the BEMT. The BEMT was built to allow the user to input cost and pricing data through a seven-step process to build a cost profile for their biobank, define direct and indirect costs, determine cost recovery fees, perform financial forecasting, and query the anonymized survey data from comparable biobanks. A survey was conducted to obtain a greater understanding of the costs involved in operating a biobank. The anonymized survey data was then used to develop the BEMT, a cost modeling tool for biobanks. Users of the tool will be able to create a cost profile for their biobanks' specimens, products and services, establish pricing, and allocate costs for biospecimens based on percent cost recovered, and perform project-specific cost analyses and financial forecasting.

Laser microdissection of sensory organ precursor cells of Drosophila microchaetes.

Directory of Open Access Journals (Sweden)

Eulalie Buffin

Full Text Available BACKGROUND: In Drosophila, each external sensory organ originates from the division of a unique precursor cell (the sensory organ precursor cell or SOP. Each SOP is specified from a cluster of equivalent cells, called a proneural cluster, all of them competent to become SOP. Although, it is well known how SOP cells are selected from proneural clusters, little is known about the downstream genes that are regulated during SOP fate specification. METHODOLOGY/PRINCIPAL FINDINGS: In order to better understand the mechanism involved in the specification of these precursor cells, we combined laser microdissection, toisolate SOP cells, with transcriptome analysis, to study their RNA profile. Using this procedure, we found that genes that exhibit a 2-fold or greater expression in SOPs versus epithelial cells were mainly associated with Gene Ontology (GO terms related with cell fate determination and sensory organ specification. Furthermore, we found that several genes such as pebbled/hindsight, scabrous, miranda, senseless, or cut, known to be expressed in SOP cells by independent procedures, are particularly detected in laser microdissected SOP cells rather than in epithelial cells. CONCLUSIONS/SIGNIFICANCE: These results confirm the feasibility and the specificity of our laser microdissection based procedure. We anticipate that this analysis will give new insight into the selection and specification of neural precursor cells.

Core catcher for nuclear reactor core meltdown containment

International Nuclear Information System (INIS)

Driscoll, M.J.; Bowman, F.L.

1978-01-01

A bed of graphite particles is placed beneath a nuclear reactor core outside the pressure vessel but within the containment building to catch the core debris in the event of failure of the emergency core cooling system. Spray cooling of the debris and graphite particles together with draining and flooding of coolant fluid of the graphite bed is provided to prevent debris slump-through to the bottom of the bed

Variations in Sense of Place Across Immigrant Status and Gender in Hamilton, Ontario; Saskatoon, Saskatchewan; and, Charlottetown, Prince Edward Island, Canada.

Science.gov (United States)

Gallina, Melissa; Williams, Allison

Past research in Hamilton, Ontario has found that age and longevity of residence are positively associated with evaluations of sense of place (SoP); further, evaluations of SoP between immigrants and Canadian-born individuals have shown no clear pattern (Williams et al. 2010; Williams and Kitchen 2012). This paper builds on this work by further examining evaluations of SoP among both immigrants and Canadian-born residents and across gender in Hamilton, while expanding the study to two other small-to-medium sized cities: Saskatoon, Saskatchewan and, Charlottetown, Prince Edward Island. This paper has two objectives: (1) to establish measures of SoP across immigrant status and gender in Hamilton, Saskatoon, and Charlottetown; and, (2) to determine how SoP varies according to immigrant status, length of residence in Canada, age, income, and neighbourhood length of residence across the three city sites. Telephone survey data (n = 1,132) was used to compare evaluations of SoP across various groups and to construct an ordered logistic regression model for SoP. Results suggest that immigrants tended to rate their SoP lower than their Canadian-born counterparts. Hamilton residents were found to rate their SoP lowest, followed by Saskatoon residents and, finally, Charlottetown residents. Younger individuals, those with lower income levels, and those with shorter neighbourhood residency in the cities concerned were more likely to have lower evaluations of SoP. This research suggests that greater attention is needed to nurture immigrants' connection with their new home.

Drilling equipment for difficult coring conditions: a new type of core lifter and triple tube core barrel

Energy Technology Data Exchange (ETDEWEB)

Robinson, J B

1968-08-01

Although considerable improvements in diamond drilling equipment have been made since the early 1950's, deficiencies in existing equipment led to the development of a new type core lifter and special 20 ft triple tube core barrel designed to operate in bad coring conditions. It is claimed that although developed essentially for coal drilling, the new equipment could be adapted to other fields of diamond drilling with the cost advantage of increased life of the core lifter.

Characterizing the Core via K-Core Covers

NARCIS (Netherlands)

Sanchez, S.M.; Borm, P.E.M.; Estevez, A.

2013-01-01

This paper extends the notion of individual minimal rights for a transferable utility game (TU-game) to coalitional minimal rights using minimal balanced families of a specific type, thus defining a corresponding minimal rights game. It is shown that the core of a TU-game coincides with the core of

DRAQ5 and Eosin ('D&E') as an Analog to Hematoxylin and Eosin for Rapid Fluorescence Histology of Fresh Tissues.

Science.gov (United States)

Elfer, Katherine N; Sholl, Andrew B; Wang, Mei; Tulman, David B; Mandava, Sree H; Lee, Benjamin R; Brown, J Quincy

2016-01-01

Real-time on-site histopathology review of biopsy tissues at the point-of-procedure has great potential for significant clinical value and improved patient care. For instance, on-site review can aid in rapid screening of diagnostic biopsies to reduce false-negative results, or in quantitative assessment of biospecimen quality to increase the efficacy of downstream laboratory and histopathology analysis. However, the only currently available rapid pathology method, frozen section analysis (FSA), is too time- and labor-intensive for use in screening large quantities of biopsy tissues and is too destructive for maximum tissue conservation in multiple small needle core biopsies. In this work we demonstrate the spectrally-compatible combination of the nuclear stain DRAQ5 and the anionic counterstain eosin as a dual-component fluorescent staining analog to hematoxylin and eosin intended for use on fresh, unsectioned tissues. Combined with optical sectioning fluorescence microscopy and pseudo-coloring algorithms, DRAQ5 and eosin ("D&E") enables very fast, non-destructive psuedohistological imaging of tissues at the point-of-acquisition with minimal tissue handling and processing. D&E was validated against H&E on a one-to-one basis on formalin-fixed paraffin-embedded and frozen section tissues of various human organs using standard epi-fluorescence microscopy, demonstrating high fidelity of the staining mechanism as an H&E analog. The method was then applied to fresh, whole 18G renal needle core biopsies and large needle core prostate biospecimen biopsies using fluorescence structured illumination optical sectioning microscopy. We demonstrate the ability to obtain high-resolution histology-like images of unsectioned, fresh tissues similar to subsequent H&E staining of the tissue. The application of D&E does not interfere with subsequent standard-of-care H&E staining and imaging, preserving the integrity of the tissue for thorough downstream analysis. These results indicate

DRAQ5 and Eosin ('D&E' as an Analog to Hematoxylin and Eosin for Rapid Fluorescence Histology of Fresh Tissues.

Directory of Open Access Journals (Sweden)

Katherine N Elfer

Full Text Available Real-time on-site histopathology review of biopsy tissues at the point-of-procedure has great potential for significant clinical value and improved patient care. For instance, on-site review can aid in rapid screening of diagnostic biopsies to reduce false-negative results, or in quantitative assessment of biospecimen quality to increase the efficacy of downstream laboratory and histopathology analysis. However, the only currently available rapid pathology method, frozen section analysis (FSA, is too time- and labor-intensive for use in screening large quantities of biopsy tissues and is too destructive for maximum tissue conservation in multiple small needle core biopsies. In this work we demonstrate the spectrally-compatible combination of the nuclear stain DRAQ5 and the anionic counterstain eosin as a dual-component fluorescent staining analog to hematoxylin and eosin intended for use on fresh, unsectioned tissues. Combined with optical sectioning fluorescence microscopy and pseudo-coloring algorithms, DRAQ5 and eosin ("D&E" enables very fast, non-destructive psuedohistological imaging of tissues at the point-of-acquisition with minimal tissue handling and processing. D&E was validated against H&E on a one-to-one basis on formalin-fixed paraffin-embedded and frozen section tissues of various human organs using standard epi-fluorescence microscopy, demonstrating high fidelity of the staining mechanism as an H&E analog. The method was then applied to fresh, whole 18G renal needle core biopsies and large needle core prostate biospecimen biopsies using fluorescence structured illumination optical sectioning microscopy. We demonstrate the ability to obtain high-resolution histology-like images of unsectioned, fresh tissues similar to subsequent H&E staining of the tissue. The application of D&E does not interfere with subsequent standard-of-care H&E staining and imaging, preserving the integrity of the tissue for thorough downstream analysis

Determination of PWR core water level using ex-core detectors signals

International Nuclear Information System (INIS)

Bernal, Alvaro; Abarca, Agustin; Miro, Rafael; Verdu, Gumersindo

2013-01-01

The core water level provides relevant neutronic and thermalhydraulic information of the reactor such as power, k eff and cooling ability; in fact, core water level monitoring could be used to predict LOCA and cooling reduction which may deal with core damage. Although different detection equipment is used to monitor several parameters such as the power, core water level monitoring is not an evident task. However, ex-core detectors can measure the fast neutrons leaking the core and several studies demonstrate the existence of a relationship between fast neutron leakage and core water level due to the shielding effect of the water. In addition, new ex-core detectors are being developed, such as silicon carbide semiconductor radiation detectors, monitoring the neutron flux with higher accuracy and in higher temperatures conditions. Therefore, a methodology to determine this relationship has been developed based on a Monte Carlo calculation using MCNP code and applying variance reduction with adjoint functions based on the adjoint flux obtained with the discrete ordinates code TORT. (author)

HYDRATE CORE DRILLING TESTS

Energy Technology Data Exchange (ETDEWEB)

John H. Cohen; Thomas E. Williams; Ali G. Kadaster; Bill V. Liddell

2002-11-01

The ''Methane Hydrate Production from Alaskan Permafrost'' project is a three-year endeavor being conducted by Maurer Technology Inc. (MTI), Noble, and Anadarko Petroleum, in partnership with the U.S. DOE National Energy Technology Laboratory (NETL). The project's goal is to build on previous and ongoing R&D in the area of onshore hydrate deposition. The project team plans to design and implement a program to safely and economically drill, core and produce gas from arctic hydrates. The current work scope includes drilling and coring one well on Anadarko leases in FY 2003 during the winter drilling season. A specially built on-site core analysis laboratory will be used to determine some of the physical characteristics of the hydrates and surrounding rock. Prior to going to the field, the project team designed and conducted a controlled series of coring tests for simulating coring of hydrate formations. A variety of equipment and procedures were tested and modified to develop a practical solution for this special application. This Topical Report summarizes these coring tests. A special facility was designed and installed at MTI's Drilling Research Center (DRC) in Houston and used to conduct coring tests. Equipment and procedures were tested by cutting cores from frozen mixtures of sand and water supported by casing and designed to simulate hydrate formations. Tests were conducted with chilled drilling fluids. Tests showed that frozen core can be washed out and reduced in size by the action of the drilling fluid. Washing of the core by the drilling fluid caused a reduction in core diameter, making core recovery very difficult (if not impossible). One successful solution was to drill the last 6 inches of core dry (without fluid circulation). These tests demonstrated that it will be difficult to capture core when drilling in permafrost or hydrates without implementing certain safeguards. Among the coring tests was a simulated hydrate

A study of the feasibility of using standards of performance funding to support investment in active solar heating systems

International Nuclear Information System (INIS)

1999-01-01

This report summarises the results of studies examining the feasibility of starting Standards of Performance (SOP) programmes to support investment in solar heating systems and develop tools for helping the implementation of the programmes. The background to the project is traced, and the scope for an active solar heating SOP scheme, the market potential for the SOP schemes in Great Britain, and the purchasing of the associated hardware within the SOP scheme are examined. (UK)

Atlantic Tropical Cyclogenetic Processes During SOP-3 NAMMA in the GEOS-5 Global Data Assimilation and Forecast System

Science.gov (United States)

Reale, Oreste; Lau, William K.; Kim, Kyu-Myong; Brin, Eugenia

2009-01-01

This article investigates the role of the Saharan air layer (SAL) in tropical cyclogenetic processes associated with a nondeveloping and a developing African easterly wave observed during the Special Observation Period (SOP-3) phase of the 2006 NASA African. Monsoon Multidisciplinary Analyses (NAMMA). The two waves are chosen because they both interact heavily with Saharan air. A glottal data assimilation and forecast system, the NASA Goddard Earth Observing System. version 5 (GEOS-5), is being run to produce a set of high-9 uality global analyses, inclusive of all observations used operationally but with additional satellite information. In particular, following previous works by the same authors, the duality-controlled data from the Atmospheric Infrared Sounder (AIRS) used to produce these analyses have a better coverage than the one adopted by operational centers. From these improved analyses, two sets of 31 five-day high-resolution forecasts, at horizontal resolutions of both half and quarter degrees, are produced. Results indicate that very steep moisture gradients are associated with the SAL in forecasts and analyses, even at great distances from their source over the Sahara. In addition, a thermal dipole in the vertiieat (warm above, cool below) is present in the nondeveloping case. The Moderate Resolution Imaging Spoctroradiometer (MODIS) aboard NASA's Terra and Aqua satellites shows that aerosol optical thickness, indicative of more dust as opposed to other factors, is higher in the nondeveloping case. Altogether, results suggest that the radiative effect of dust may play some role in producing a thermal structure less favorable to cyclogenesis. Results also indicate that only global horizontal resolutions on the order of 20-30 km can capture the large-scale transport and the tine thermal structure of the SAL, inclusive of the sharp moisture gradients, reproducing the effect of tropical cyclone suppression that has been hypothesized by previous authors

78 FR 59034 - Agency Information Collection Activities; Proposed Collection; Comment Request

Science.gov (United States)

2013-09-25

... Culture (Ambulatory Surgery SOPS) will measure ASC staff perceptions about what is important in their... Safety Culture Questionnaire (Ambulatory Surgery SOPS).'' In accordance with the Paperwork Reduction Act... Ambulatory Surgery/Procedure Survey on Patient Safety Culture Questionnaire (Ambulatory Surgery SOPS) One...

Rotary core drills

Energy Technology Data Exchange (ETDEWEB)

1967-11-30

The design of a rotary core drill is described. Primary consideration is given to the following component parts of the drill: the inner and outer tube, the core bit, an adapter, and the core lifter. The adapter has the form of a downward-converging sleeve and is mounted to the lower end of the inner tube. The lifter, extending from the adapter, is split along each side so that it can be held open to permit movement of a core. It is possible to grip a core by allowing the lifter to assume a closed position.

Metallic nanoshells with semiconductor cores: optical characteristics modified by core medium properties.

Science.gov (United States)

Bardhan, Rizia; Grady, Nathaniel K; Ali, Tamer; Halas, Naomi J

2010-10-26

It is well-known that the geometry of a nanoshell controls the resonance frequencies of its plasmon modes; however, the properties of the core material also strongly influence its optical properties. Here we report the synthesis of Au nanoshells with semiconductor cores of cuprous oxide and examine their optical characteristics. This material system allows us to systematically examine the role of core material on nanoshell optical properties, comparing Cu(2)O core nanoshells (ε(c) ∼ 7) to lower core dielectric constant SiO(2) core nanoshells (ε(c) = 2) and higher dielectric constant mixed valency iron oxide nanoshells (ε(c) = 12). Increasing the core dielectric constant increases nanoparticle absorption efficiency, reduces plasmon line width, and modifies plasmon energies. Modifying the core medium provides an additional means of tailoring both the near- and far-field optical properties in this unique nanoparticle system.

Proteomics Core

Data.gov (United States)

Federal Laboratory Consortium — Proteomics Core is the central resource for mass spectrometry based proteomics within the NHLBI. The Core staff help collaborators design proteomics experiments in a...

A core performance study on an actinide recycling 'zero-sodium-void worth' core

International Nuclear Information System (INIS)

Kawashima, M.; Nakagawa, M.; Yamaoka, M.; Kasahara, F.

1994-01-01

A core performance study was made for an absorber-type parfait core (A-APC) as one of 'Zero-sodium-void-worth' core concepts. This evaluation study pursued different two aspects; one for transuranic (TRU) management strategy, and another for a loss-of-coolant anticipated transient behavior considering the unique core configuration. The results indicated that this core has a large flexibility for actinide recycling in terms of self-sufficiency and minor actinide burning. The result also showed that this core has kept a large mitigation potential for ULOF events as well as a simple flat core concept, reflecting detailed three dimensional core bowing behavior for the A-APC configuration. (author)

Preliminaries on core image analysis using fault drilling samples; Core image kaiseki kotohajime (danso kussaku core kaisekirei)

Energy Technology Data Exchange (ETDEWEB)

Miyazaki, T; Ito, H [Geological Survey of Japan, Tsukuba (Japan)

1996-05-01

This paper introduces examples of image data analysis on fault drilling samples. The paper describes the following matters: core samples used in the analysis are those obtained from wells drilled piercing the Nojima fault which has moved in the Hygoken-Nanbu Earthquake; the CORESCAN system made by DMT Corporation, Germany, used in acquiring the image data consists of a CCD camera, a light source and core rotation mechanism, and a personal computer, its resolution being about 5 pixels/mm in both axial and circumferential directions, and 24-bit full color; with respect to the opening fractures in core samples collected by using a constant azimuth coring, it was possible to derive values of the opening width, inclination angle, and travel from the image data by using a commercially available software for the personal computer; and comparison of this core image with the BHTV record and the hydrophone VSP record (travel and inclination obtained from the BHTV record agree well with those obtained from the core image). 4 refs., 4 figs.

75 FR 28763 - Permission To Use Air Inflation of Meat Carcasses and Parts

Science.gov (United States)

2010-05-24

... Point (HACCP) plans or Sanitation standard operating procedures (Sanitation SOPs) or other prerequisite... into their HACCP plans or Sanitation SOPs or other prerequisite programs. In addition, FSIS is... incorporate their air inflation procedures into their HACCP plans or Sanitation SOPs or other prerequisite...

Macrophage activation induced by the polysaccharides isolated from the roots of Sanguisorba officinalis.

Science.gov (United States)

Tong, Haibin; Mao, Dirui; Zhai, Mingyue; Zhang, Zhuorui; Sun, Guangren; Jiang, Guiquan

2015-01-01

Macrophage, involved at all stages of immune response, is an important component of the host defense system. Polysaccharides exist almost ubiquitously in medical plants and most of them possess immunomodulation and macrophage activation properties. This study elucidates the effects on macrophage activation and molecular mechanism induced by the polysaccharides (SOPs) from the roots of Sanguisorba officinalis Linne (Rosaceae). Polysaccharides (SOPs) from the roots of S. officinalis were obtained by water extraction and ethanol precipitation. Physicochemical characterization of SOPs was analyzed by phenol-sulfuric acid, m-hydroxydiphenyl, Bradford method, and gas chromatography. Phagocytic capacity of RAW 264.7 macrophages incubated with SOPs (25 and 100 μg/ml) was determined by the aseptic neutral red method. Macrophages were incubated with SOPs (25 and 100 μg/ml), and the TNF-α and NO the secretion were measured using ELISA kit and Griess reagent, respectively. In addition, TNF-α and iNOS transcripts were evaluated by semi-quantitative RT-PCR, and NF-κB signaling activation was detected by Western blot assay. SOPs enhanced the phagocytosis capacity of macrophages to aseptic neutral red solution and increased TNF-α and NO secretion. The amounts of TNF-α and iNOS transcript were increased significantly at the mRNA level when macrophages were exposed to SOPs. Meanwhile, the stimulation of macrophages by SOPs induced phosphorylation of p65 at serine 536 and a marked decrease of IκB expression. These results suggested that SOPs exhibited significant macrophage activation properties through NF-κB signaling pathway and could be considered as a new immunopotentiator.

Sidewall coring shell

Energy Technology Data Exchange (ETDEWEB)

Edelman, Ya A; Konstantinov, L P; Martyshin, A N

1966-12-12

A sidewall coring shell consists of a housing and a detachable core catcher. The core lifter is provided with projections, the ends of which are situated in another plane, along the longitudinal axis of the lifter. The chamber has corresponding projections.

The NASA Ames Research Center Institutional Scientific Collection: History, Best Practices and Scientific Opportunities

Science.gov (United States)

Rask, Jon C.; Chakravarty, Kaushik; French, Alison; Choi, Sungshin; Stewart, Helen

2017-01-01

The NASA Ames Life Sciences Institutional Scientific Collection (ISC), which is composed of the Ames Life Sciences Data Archive (ALSDA) and the Biospecimen Storage Facility (BSF), is managed by the Space Biosciences Division and has been operational since 1993. The ALSDA is responsible for archiving information and animal biospecimens collected from life science spaceflight experiments and matching ground control experiments. Both fixed and frozen spaceflight and ground tissues are stored in the BSF within the ISC. The ALSDA also manages a Biospecimen Sharing Program, performs curation and long-term storage operations, and makes biospecimens available to the scientific community for research purposes via the Life Science Data Archive public website (https:lsda.jsc.nasa.gov). As part of our best practices, a viability testing plan has been developed for the ISC, which will assess the quality of archived samples. We expect that results from the viability testing will catalyze sample use, enable broader science community interest, and improve operational efficiency of the ISC. The current viability test plan focuses on generating disposition recommendations and is based on using ribonucleic acid (RNA) integrity number (RIN) scores as a criteria for measurement of biospecimen viablity for downstream functional analysis. The plan includes (1) sorting and identification of candidate samples, (2) conducting a statiscally-based power analysis to generate representaive cohorts from the population of stored biospecimens, (3) completion of RIN analysis on select samples, and (4) development of disposition recommendations based on the RIN scores. Results of this work will also support NASA open science initiatives and guides development of the NASA Scientific Collections Directive (a policy on best practices for curation of biological collections). Our RIN-based methodology for characterizing the quality of tissues stored in the ISC since the 1980s also creates unique

Electromagnetically driven westward drift and inner-core superrotation in Earth's core.

Science.gov (United States)

Livermore, Philip W; Hollerbach, Rainer; Jackson, Andrew

2013-10-01

A 3D numerical model of the earth's core with a viscosity two orders of magnitude lower than the state of the art suggests a link between the observed westward drift of the magnetic field and superrotation of the inner core. In our model, the axial electromagnetic torque has a dominant influence only at the surface and in the deepest reaches of the core, where it respectively drives a broad westward flow rising to an axisymmetric equatorial jet and imparts an eastward-directed torque on the solid inner core. Subtle changes in the structure of the internal magnetic field may alter not just the magnitude but the direction of these torques. This not only suggests that the quasi-oscillatory nature of inner-core superrotation [Tkalčić H, Young M, Bodin T, Ngo S, Sambridge M (2013) The shuffling rotation of the earth's inner core revealed by earthquake doublets. Nat Geosci 6:497-502.] may be driven by decadal changes in the magnetic field, but further that historical periods in which the field exhibited eastward drift were contemporaneous with a westward inner-core rotation. The model further indicates a strong internal shear layer on the tangent cylinder that may be a source of torsional waves inside the core.

Improving the calculated core stability by the core nuclear design optimization

International Nuclear Information System (INIS)

Partanen, P.

1995-01-01

Three different equilibrium core loadings for TVO II reactor have been generated in order to improve the core stability properties at uprated power level. The reactor thermal power is assumed to be uprated from 2160 MW th to 2500 MW th , which moves the operating point after a rapid pump rundown where the core stability has been calculated from 1340 MW th and 3200 kg/s to 1675 MW th and 4000 kg/s. The core has been refuelled with ABB Atom Svea-100 -fuel, which has 3,64% w/o U-235 average enrichment in the highly enriched zone. PHOENIX lattice code has been used to provide the homogenized nuclear constants. POLCA4 static core simulator has been used for core loadings and cycle simulations and RAMONA-3B program for simulating the dynamic response to the disturbance for which the stability behaviour has been evaluated. The core decay ratio has been successfully reduced from 0,83 to 0,55 mainly by reducing the power peaking factors. (orig.) (7 figs., 1 tab.)

Core Values | NREL

Science.gov (United States)

Core Values Core Values NREL's core values are rooted in a safe and supportive work environment guide our everyday actions and efforts: Safe and supportive work environment Respect for the rights physical and social environment Integrity Maintain the highest standard of ethics, honesty, and integrity

Seismic core shroud

International Nuclear Information System (INIS)

Puri, A.; Mullooly, J.F.

1981-01-01

A core shroud is provided, comprising: a coolant boundary, following the shape of the core boundary, for channeling the coolant through the fuel assemblies; a cylindrical band positioned inside the core barrel and surrounding the coolant boundary; and support members extending from the coolant boundary to the band, for transferring load from the coolant boundary to the band. The shroud may be assembled in parts using automated welding techniques, and it may be adjusted to fit the reactor core easily

Global diabatic heating during FGGE SOP-1 and SOP-2

Science.gov (United States)

Chen, Tsing-Chang; Baker, Wayman E.

1986-01-01

With the increase in the observational data provided by FGGE and the use of global circulation models with full physics for the data assimilation, it is now becoming feasible to attempt to estimate globally the atmospheric diabatic heating. The thermodynamic equation in isobaric coordinates and the data generated by the FGGE III-b analysis of the Goddard Laboratory for Atmospheres (GLA) are employed to serve this purpose. The results of the present study generally agree with other previous investigations. However, some important differences are also revealed. (1) The diabatic heating obtained in the tropics in the present study is larger than that obtained elsewhere; (2) the relatively large heating over the mountainous areas shown in other studies does not appear; (3) no significant negative values of diabatic heating are found in the polar regions; and (4) unlike other studies, cooling is noted over parts of Eurasia in the summer.

Workflow Optimization in Vertebrobasilar Occlusion

International Nuclear Information System (INIS)

Kamper, Lars; Meyn, Hannes; Rybacki, Konrad; Nordmeyer, Simone; Kempkes, Udo; Piroth, Werner; Isenmann, Stefan; Haage, Patrick

2012-01-01

Objective: In vertebrobasilar occlusion, rapid recanalization is the only substantial means to improve the prognosis. We introduced a standard operating procedure (SOP) for interventional therapy to analyze the effects on interdisciplinary time management. Methods: Intrahospital time periods between hospital admission and neuroradiological intervention were retrospectively analyzed, together with the patients’ outcome, before (n = 18) and after (n = 20) implementation of the SOP. Results: After implementation of the SOP, we observed statistically significant improvement of postinterventional patient neurological status (p = 0.017). In addition, we found a decrease of 5:33 h for the mean time period from hospital admission until neuroradiological intervention. The recanalization rate increased from 72.2% to 80% after implementation of the SOP. Conclusion: Our results underscore the relevance of SOP implementation and analysis of time management for clinical workflow optimization. Both may trigger awareness for the need of efficient interdisciplinary time management. This could be an explanation for the decreased time periods and improved postinterventional patient status after SOP implementation.

[caCORE: core architecture of bioinformation on cancer research in America].

Science.gov (United States)

Gao, Qin; Zhang, Yan-lei; Xie, Zhi-yun; Zhang, Qi-peng; Hu, Zhang-zhi

2006-04-18

A critical factor in the advancement of biomedical research is the ease with which data can be integrated, redistributed and analyzed both within and across domains. This paper summarizes the Biomedical Information Core Infrastructure built by National Cancer Institute Center for Bioinformatics in America (NCICB). The main product from the Core Infrastructure is caCORE--cancer Common Ontologic Reference Environment, which is the infrastructure backbone supporting data management and application development at NCICB. The paper explains the structure and function of caCORE: (1) Enterprise Vocabulary Services (EVS). They provide controlled vocabulary, dictionary and thesaurus services, and EVS produces the NCI Thesaurus and the NCI Metathesaurus; (2) The Cancer Data Standards Repository (caDSR). It provides a metadata registry for common data elements. (3) Cancer Bioinformatics Infrastructure Objects (caBIO). They provide Java, Simple Object Access Protocol and HTTP-XML application programming interfaces. The vision for caCORE is to provide a common data management framework that will support the consistency, clarity, and comparability of biomedical research data and information. In addition to providing facilities for data management and redistribution, caCORE helps solve problems of data integration. All NCICB-developed caCORE components are distributed under open-source licenses that support unrestricted usage by both non-profit and commercial entities, and caCORE has laid the foundation for a number of scientific and clinical applications. Based on it, the paper expounds caCORE-base applications simply in several NCI projects, of which one is CMAP (Cancer Molecular Analysis Project), and the other is caBIG (Cancer Biomedical Informatics Grid). In the end, the paper also gives good prospects of caCORE, and while caCORE was born out of the needs of the cancer research community, it is intended to serve as a general resource. Cancer research has historically

Analysis of core and core barrel heat-up under conditions simulating severe reactor accidents

International Nuclear Information System (INIS)

Chellaiah, S.; Viskanta, R.; Ranganathan, P.; Anand, N.K.

1987-01-01

This paper reports on the development of a model for estimating the temperature distributions in the reactor core, core barrel, thermal shield and reactor pressure vessel of a PWR during an undercooling transient. A number of numerical calculations simulating the core uncovering of the TMI-2 reactor and the subsequent heat-up of the core have been performed. The results of the calculations show that the exothermic heat release due to Zircaloy oxidation contributes to the sharp heat-up of the core. However, the core barrel temperature rise which is driven by the temperature increase of the edge of the core (e.g., the core baffle) is very modest. The maximum temperature of the core barrel never exceeded 610 K (at a system pressure of 68 bar) after a 75 minute simulation following the start of core uncovering

Overview of core designs and requirements/criteria for core restraint systems

International Nuclear Information System (INIS)

Sutherland, W.H.

1984-09-01

The requirements and lifetime criteria for the design of a Liquid Metal Fast Breeder Reactor (LMFBR) Core Restraint System are presented. A discussion of the three types of core restraint systems used in LMFBR core design is given. Details of the core restraint system selected for FFTF are presented and the reasons for this selection given. Structural analysis procedures being used to manage the FFTF assembly irradiations are discussed. Efforts that are ongoing to validate the calculational methods and lifetime criteria are presented

Theoretical Investigation of Inter-core Crosstalk Properties in Homogeneous Trench-Assisted Multi-Core Fibers

DEFF Research Database (Denmark)

Ye, Feihong; Morioka, Toshio; Tu, Jiajing

2014-01-01

We derive analytical expressions for inter-core crosstalk, its dependence on core pitch and wavelength in homogeneous trench-assisted multi-core fibers. They are in excellent agreement with numerical simulation results.......We derive analytical expressions for inter-core crosstalk, its dependence on core pitch and wavelength in homogeneous trench-assisted multi-core fibers. They are in excellent agreement with numerical simulation results....

Safeguarding donors' personal rights and biobank autonomy in biobank networks: the CRIP privacy regime.

Science.gov (United States)

Schröder, Christina; Heidtke, Karsten R; Zacherl, Nikolaus; Zatloukal, Kurt; Taupitz, Jochen

2011-08-01

Governance, underlying general ICT (Information and Communication Technology) architecture, and workflow of the Central Research Infrastructure for molecular Pathology (CRIP) are discussed as a model enabling biobank networks to form operational "meta biobanks" whilst respecting the donors' privacy, biobank autonomy and confidentiality, and the researchers' needs for appropriate biospecimens and information, as well as confidentiality. Tailored to these needs, CRIP efficiently accelerates and facilitates research with human biospecimens and data.

Neutronic design of mixed oxide-silicide cores for the core conversion of rsg-gas reactor

International Nuclear Information System (INIS)

Sembiring, Tagor Malem; Tukiran; Pinem surian; Febrianto

2001-01-01

The core conversion of rsg-gas reactor from an all-oxide (U 3 O 8 -Al) core, through a series of mixed oxide-silicide core, to an all-silicide (U 3 Si 2 -Al) core for the same meat density of 2.96 g U/cc is in progress. The conversion is first step of the step-wise conversion and will be followed by the second step that is the core conversion from low meat density of silicide core, through a series of mixed lower-higher density of silicide core, to an all-higher meat density of 3.55 g/cc core. Therefore, the objectives of this work is to design the mixed cores on the neutronic performance to achieve safety a first full-silicide core for the reactor with the low uranium meat density of 2.96gU/cc. The neutronic design of the mixed cores was performed by means of Batan-EQUIL-2D and Batan-3DIFF computer codes for 2 and 3 dimension diffusion calculation, respectively. The result shows that all mixed oxide-silicide cores will be feasible to achieve safety a fist full-silicide core. The core performs the same neutronic core parameters as those of the equilibrium silicide core. Therefore, the reactor availability and utilization during the core conversion is not changed

Overview of core designs and requirements/criteria for core restraint systems

International Nuclear Information System (INIS)

Sutherland, W.H.

1984-01-01

The requirements and lifetime criteria for the design of a Liquid Metal Fast Breeder Reactor (LMFBR) Core Restraint System is presented. A discussion of the three types of core restraint systems used in LMFBR core design is given. Details of the core restraint system selected for FFTF are presented and the reasons for this selection given. Structural analysis procedures being used to manage the FFTF assembly irradiations are discussed. Efforts that are ongoing to validate the calculational methods and lifetime criteria are presented. (author)

Nuclear reactor core flow baffling

International Nuclear Information System (INIS)

Berringer, R.T.

1979-01-01

A flow baffling arrangement is disclosed for the core of a nuclear reactor. A plurality of core formers are aligned with the grids of the core fuel assemblies such that the high pressure drop areas in the core are at the same elevations as the high pressure drop areas about the core periphery. The arrangement minimizes core bypass flow, maintains cooling of the structure surrounding the core, and allows the utilization of alternative beneficial components such as neutron reflectors positioned near the core

Espaço de cores

Directory of Open Access Journals (Sweden)

Claudia Feitosa-Santana

2006-01-01

Full Text Available O artigo apresenta definições para os termos espaço de cores e sistemas de cores; classifica, de acordo com David Brainard (2003, os sistemas de cores em dois grupos: aparência de cores e diferenças de cores. Dentre os diversos sistemas de cores existentes, o artigo descreve dois deles: o sistema de cores Munsell &– um dos mais utilizados entre os sistemas de aparência de cores &– e a descrição do sistema de cores CIE 1931 &– um dos mais utilizados dentre os sistemas de diferença de cores. Faz-se uma retrospectiva histórica da busca por espaços de cores que representem a percepção de cores humana assim como as diversas reconstruções de espaços de cores por métodos eletrofisiológicos ou psicofísicos. Muitas dessas reconstruções utilizam a escala multidimensional (mds. O artigo também introduz a possibilidade da reconstrução dos espaços de cores de pacientes com discromatopsia adquirida como uma distorção do espaço de indivíduos tricromatas normais.

Core antigen and circulating anti-core antibody in hepatitis B infection

Energy Technology Data Exchange (ETDEWEB)

Howard, C R; Zuckerman, A J [London School of Hygiene and Tropical Medicine (UK)

1977-02-01

Core antigen was obtained from the sera of persistent chronic carriers of hepatitis B virus by centrifugation and treatment with Nonidet P40 and 2-mercaptoethanol. The separated core antigen was radiolabelled and identified as a nucleoprotein structure of buoyant density 1.36 g/cm/sup 3/ and possessing an isoelectric point of 4.4. This material was employed in a radioimmnoassay procedure of high sensitivity for the detection of core antibody. In a series of sera from patients with acute type B hepatitis, core antibody was demonstrated 2 to 3 weeks after the onset of jaundice during the period of surface antigenaemia. The presence of core antibody may therefore provide an accurate serological marker for the detection of active or recent virus replication in future epidemiological studies of hepatitis B infection.

Internal core tightener

International Nuclear Information System (INIS)

Brynsvold, G.V.; Snyder, H.J. Jr.

1976-01-01

An internal core tightener is disclosed which is a linear actuated (vertical actuation motion) expanding device utilizing a minimum of moving parts to perform the lateral tightening function. The key features are: (1) large contact areas to transmit loads during reactor operation; (2) actuation cam surfaces loaded only during clamping and unclamping operation; (3) separation of the parts and internal operation involved in the holding function from those involved in the actuation function; and (4) preloaded pads with compliant travel at each face of the hexagonal assembly at the two clamping planes to accommodate thermal expansion and irradiation induced swelling. The latter feature enables use of a ''fixed'' outer core boundary, and thus eliminates the uncertainty in gross core dimensions, and potential for rapid core reactivity changes as a result of core dimensional change. 5 claims, 12 drawing figures

Tissue Banking, Bioinformatics, and Electronic Medical Records: The Front-End Requirements for Personalized Medicine

Science.gov (United States)

Suh, K. Stephen; Sarojini, Sreeja; Youssif, Maher; Nalley, Kip; Milinovikj, Natasha; Elloumi, Fathi; Russell, Steven; Pecora, Andrew; Schecter, Elyssa; Goy, Andre

2013-01-01

Personalized medicine promises patient-tailored treatments that enhance patient care and decrease overall treatment costs by focusing on genetics and “-omics” data obtained from patient biospecimens and records to guide therapy choices that generate good clinical outcomes. The approach relies on diagnostic and prognostic use of novel biomarkers discovered through combinations of tissue banking, bioinformatics, and electronic medical records (EMRs). The analytical power of bioinformatic platforms combined with patient clinical data from EMRs can reveal potential biomarkers and clinical phenotypes that allow researchers to develop experimental strategies using selected patient biospecimens stored in tissue banks. For cancer, high-quality biospecimens collected at diagnosis, first relapse, and various treatment stages provide crucial resources for study designs. To enlarge biospecimen collections, patient education regarding the value of specimen donation is vital. One approach for increasing consent is to offer publically available illustrations and game-like engagements demonstrating how wider sample availability facilitates development of novel therapies. The critical value of tissue bank samples, bioinformatics, and EMR in the early stages of the biomarker discovery process for personalized medicine is often overlooked. The data obtained also require cross-disciplinary collaborations to translate experimental results into clinical practice and diagnostic and prognostic use in personalized medicine. PMID:23818899

Application Service Providers (ASP Adoption in Core and Non-Core Functions

Directory of Open Access Journals (Sweden)

Aman Y.M. Chan

2009-10-01

Full Text Available With the further improvement in internet bandwidth, connection stability and data transmission security, a new wave of Application Service Providers (ASP is on his way. The recent booming on some models such as Software Application as Service (SaaS and On-Demand in 2008, has led to emergence of ASP model in core business functions. The traditional IS outsourcing covers the non-core business functions that are not critical to business performance and competitive advantages. Comparing with traditional IS outsourcing, ASP is a new phenomenon that can be considered as an emerging innovation as it covers both core and non-core business functions. Most of the executives do not comprehend the difference and similarity between traditional IS outsourcing and ASP mode. Hence, we propose to conduct a research so as to identify the determinants (cost benefit, gap in IS capability complementing the company's strategic goal, and trust to ASP's service and security level and moderating factors (management's attitude in ownership & control, and company aggressiveness of ASP adoption decision in both core and non-core business functions.

Reactor core

International Nuclear Information System (INIS)

Azekura, Kazuo; Kurihara, Kunitoshi.

1992-01-01

In a BWR type reactor, a great number of pipes (spectral shift pipes) are disposed in the reactor core. Moderators having a small moderating cross section (heavy water) are circulated in the spectral shift pipes to suppress the excess reactivity while increasing the conversion ratio at an initial stage of the operation cycle. After the intermediate stage of the operation cycle in which the reactor core reactivity is lowered, reactivity is increased by circulating moderators having a great moderating cross section (light water) to extend the taken up burnup degree. Further, neutron absorbers such as boron are mixed to the moderator in the spectral shift pipe to control the concentration thereof. With such a constitution, control rods and driving mechanisms are no more necessary, to simplify the structure of the reactor core. This can increase the fuel conversion ratio and control great excess reactivity. Accordingly, a nuclear reactor core of high conversion and high burnup degree can be attained. (I.N.)

Electromagnetically driven westward drift and inner-core superrotation in Earth’s core

Science.gov (United States)

Livermore, Philip W.; Hollerbach, Rainer; Jackson, Andrew

2013-01-01

A 3D numerical model of the earth’s core with a viscosity two orders of magnitude lower than the state of the art suggests a link between the observed westward drift of the magnetic field and superrotation of the inner core. In our model, the axial electromagnetic torque has a dominant influence only at the surface and in the deepest reaches of the core, where it respectively drives a broad westward flow rising to an axisymmetric equatorial jet and imparts an eastward-directed torque on the solid inner core. Subtle changes in the structure of the internal magnetic field may alter not just the magnitude but the direction of these torques. This not only suggests that the quasi-oscillatory nature of inner-core superrotation [Tkalčić H, Young M, Bodin T, Ngo S, Sambridge M (2013) The shuffling rotation of the earth’s inner core revealed by earthquake doublets. Nat Geosci 6:497–502.] may be driven by decadal changes in the magnetic field, but further that historical periods in which the field exhibited eastward drift were contemporaneous with a westward inner-core rotation. The model further indicates a strong internal shear layer on the tangent cylinder that may be a source of torsional waves inside the core. PMID:24043841

Inner Core Rotation from Geomagnetic Westward Drift and a Stationary Spherical Vortex in Earth's Core

Science.gov (United States)

Voorhies, C. V.

1999-01-01

The idea that geomagnetic westward drift indicates convective leveling of the planetary momentum gradient within Earth's core is pursued in search of a differentially rotating mean state, upon which various oscillations and secular effects might be superimposed. The desired state conforms to roughly spherical boundary conditions, minimizes dissipative interference with convective cooling in the bulk of the core, yet may aide core cooling by depositing heat in the uppermost core and lower mantle. The variational calculus of stationary dissipation applied to a spherical vortex within the core yields an interesting differential rotation profile akin to spherical Couette flow bounded by thin Hartmann layers. Four boundary conditions are required. To concentrate shear induced dissipation near the core-mantle boundary, these are taken to be: (i) no-slip at the core-mantle interface; (ii) geomagnetically estimated bulk westward flow at the base of the core-mantle boundary layer; (iii) no-slip at the inner-outer core interface; and, to describe magnetic locking of the inner core to the deep outer core, (iv) hydrodynamically stress-free at the inner-outer core boundary. By boldly assuming the axial core angular momentum anomaly to be zero, the super-rotation of the inner core is calculated to be at most 1.5 degrees per year.

A second wave of Salmonella T3SS1 activity prolongs the lifespan of infected epithelial cells.

Directory of Open Access Journals (Sweden)

Ciaran E Finn

2017-04-01

Full Text Available Type III secretion system 1 (T3SS1 is used by the enteropathogen Salmonella enterica serovar Typhimurium to establish infection in the gut. Effector proteins translocated by this system across the plasma membrane facilitate invasion of intestinal epithelial cells. One such effector, the inositol phosphatase SopB, contributes to invasion and mediates activation of the pro-survival kinase Akt. Following internalization, some bacteria escape from the Salmonella-containing vacuole into the cytosol and there is evidence suggesting that T3SS1 is expressed in this subpopulation. Here, we investigated the post-invasion role of T3SS1, using SopB as a model effector. In cultured epithelial cells, SopB-dependent Akt phosphorylation was observed at two distinct stages of infection: during and immediately after invasion, and later during peak cytosolic replication. Single cell analysis revealed that cytosolic Salmonella deliver SopB via T3SS1. Although intracellular replication was unaffected in a SopB deletion mutant, cells infected with ΔsopB demonstrated a lack of Akt phosphorylation, earlier time to death, and increased lysis. When SopB expression was induced specifically in cytosolic Salmonella, these effects were restored to levels observed in WT infected cells, indicating that the second wave of SopB protects this infected population against cell death via Akt activation. Thus, T3SS1 has two, temporally distinct roles during epithelial cell colonization. Additionally, we found that delivery of SopB by cytosolic bacteria was translocon-independent, in contrast to canonical effector translocation across eukaryotic membranes, which requires formation of a translocon pore. This mechanism was also observed for another T3SS1 effector, SipA. These findings reveal the functional and mechanistic adaptability of a T3SS that can be harnessed in different microenvironments.

Social object play among young Japanese macaques (Macaca fuscata) in Arashiyama, Japan.

Science.gov (United States)

Shimada, Masaki

2006-10-01

Social object play (SOP), i.e., social play using portable object(s), among young Japanese macaques (Macaca fuscata; 0-4 years old) in the Arashiyama E troop was studied using a modified sequence sampling method from July to October 2000. SOP was a relatively common activity for most of the young macaques and often continued for long periods. Participants used many kinds of object, including edible natural objects and artificial objects, such as plastic bottles, but they never used provisioned food or wild fruit in SOP bouts. An analysis of long bouts (>/=0.5 min) revealed the following interactive SOP features: (1) at any given time, participants used only one object, and only one participant held the object; (2) during SOP play-chasing, the object holder was likely to be chased by others; (3) during long bouts, the object changed hands frequently; and (4) agonistic competition for an object among young macaques was rare. Combinations of sexes, ages, relative ranks, or matrilines of the object holder and non-holder did not affect the tendency that the holder was chased by non-holder(s) during play-chasing. Even when there was a change in object holders, the repetitiveness of this interactive pattern, i.e., that the holder would be chased during SOP bouts, distinguished the SOP structure from that of other types of social play without object(s). General proximate social play mechanisms, such as self-handicapping or role taking, were associated with SOP. Other mechanisms that affected SOP included the following: (1) young macaques treated an object as a target in play competition, and (2) 'being the holder of a target object' was associated with the 'role of the chasee.'

Epistemology and ontology in core ontologies: FOLaw and LRI-Core, two core ontologies for law

NARCIS (Netherlands)

Breukers, J.A.P.J.; Hoekstra, R.J.

2004-01-01

For more than a decade constructing ontologies for legal domains, we, at the Leibniz Center for Law, felt really the need to develop a core ontology for law that would enable us to re-use the common denominator of the various legal domains. In this paper we present two core ontologies for law. The

Transformer core

NARCIS (Netherlands)

Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

2008-01-01

A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

Transformer core

NARCIS (Netherlands)

Mehendale, A.; Hagedoorn, Wouter; Lötters, Joost Conrad

2010-01-01

A transformer core includes a stack of a plurality of planar core plates of a magnetically permeable material, which plates each consist of a first and a second sub-part that together enclose at least one opening. The sub-parts can be fitted together via contact faces that are located on either side

[Core muscle chains activation during core exercises determined by EMG-a systematic review].

Science.gov (United States)

Rogan, Slavko; Riesen, Jan; Taeymans, Jan

2014-10-15

Good core muscles strength is essential for daily life and sports activities. However, the mechanism how core muscles may be effectively triggered by exercises is not yet precisely described in the literature. The aim of this systematic review was to evaluate the rate of activation as measured by electromyography of the ventral, lateral and dorsal core muscle chains during core (trunk) muscle exercises. A total of 16 studies were included. Exercises with a vertical starting position, such as the deadlift or squat activated significantly more core muscles than exercises in the horizontal initial position.

Risk reduction of core-melt accidents in advaned CAPRA burner cores

International Nuclear Information System (INIS)

Maschek, W.; Struwe, D.; Eigemann, M.

1997-01-01

As part of the CAPRA Program (Consommation Accrue de Plutonium dans les RApides) the feasibility of fast reactors is investigated to burn plutonium and also to destruct minor actinides. The design of CAPRA cores shows significant differences compared to conventional cores. Especially the high Pu-enrichment has an important influence on the core melt-down behavior and the associated recriticality risk. To cope with this risk, inherent design features and special measures/devices are investigated for their potential of early fuel discharge to reduce the criticality of the reactor core. An assessment of such measures/devices is given and experimental needs are formulated. 11 refs., 5 figs

Animal MRI Core

Data.gov (United States)

Federal Laboratory Consortium — The Animal Magnetic Resonance Imaging (MRI) Core develops and optimizes MRI methods for cardiovascular imaging of mice and rats. The Core provides imaging expertise,...

Error Analysis of High Frequency Core Loss Measurement for Low-Permeability Low-Loss Magnetic Cores

DEFF Research Database (Denmark)

Niroumand, Farideh Javidi; Nymand, Morten

2016-01-01

in magnetic cores is B-H loop measurement where two windings are placed on the core under test. However, this method is highly vulnerable to phase shift error, especially for low-permeability, low-loss cores. Due to soft saturation and very low core loss, low-permeability low-loss magnetic cores are favorable...... in many of the high-efficiency high power-density power converters. Magnetic powder cores, among the low-permeability low-loss cores, are very attractive since they possess lower magnetic losses in compared to gapped ferrites. This paper presents an analytical study of the phase shift error in the core...... loss measuring of low-permeability, low-loss magnetic cores. Furthermore, the susceptibility of this measurement approach has been analytically investigated under different excitations. It has been shown that this method, under square-wave excitation, is more accurate compared to sinusoidal excitation...

The core paradox.

Science.gov (United States)

Kennedy, G. C.; Higgins, G. H.

1973-01-01

Rebuttal of suggestions from various critics attempting to provide an escape from the seeming paradox originated by Higgins and Kennedy's (1971) proposed possibility that the liquid in the outer core was thermally stably stratified and that this stratification might prove a powerful inhibitor to circulation of the outer core fluid of the kind postulated for the generation of the earth's magnetic field. These suggestions are examined and shown to provide no reasonable escape from the core paradox.

s-core network decomposition: A generalization of k-core analysis to weighted networks

Science.gov (United States)

Eidsaa, Marius; Almaas, Eivind

2013-12-01

A broad range of systems spanning biology, technology, and social phenomena may be represented and analyzed as complex networks. Recent studies of such networks using k-core decomposition have uncovered groups of nodes that play important roles. Here, we present s-core analysis, a generalization of k-core (or k-shell) analysis to complex networks where the links have different strengths or weights. We demonstrate the s-core decomposition approach on two random networks (ER and configuration model with scale-free degree distribution) where the link weights are (i) random, (ii) correlated, and (iii) anticorrelated with the node degrees. Finally, we apply the s-core decomposition approach to the protein-interaction network of the yeast Saccharomyces cerevisiae in the context of two gene-expression experiments: oxidative stress in response to cumene hydroperoxide (CHP), and fermentation stress response (FSR). We find that the innermost s-cores are (i) different from innermost k-cores, (ii) different for the two stress conditions CHP and FSR, and (iii) enriched with proteins whose biological functions give insight into how yeast manages these specific stresses.

The AVRDC - The World Vegetable Center mungbean (Vigna radiata) core and mini core collections.

Science.gov (United States)

Schafleitner, Roland; Nair, Ramakrishnan Madhavan; Rathore, Abhishek; Wang, Yen-wei; Lin, Chen-yu; Chu, Shu-hui; Lin, Pin-yun; Chang, Jian-Cheng; Ebert, Andreas W

2015-04-29

Large ex situ germplasm collections generally harbor a wide range of crop diversity. AVRDC--The World Vegetable Center is holding in trust the world's second largest mungbean (Vigna radiata) germplasm collection with more than 6,700 accessions. Screening large collections for traits of interest is laborious and expensive. To enhance the access of breeders to the diversity of the crop, mungbean core and mini core collections have been established. The core collection of 1,481 entries has been built by random selection of 20% of the accessions after geographical stratification and subsequent cluster analysis of eight phenotypic descriptors in the whole collection. Summary statistics, especially the low differences of means, equal variance of the traits in both the whole and core collection and the visual inspection of quantile-quantile plots comparing the variation of phenotypic traits present in both collections indicated that the core collection well represented the pattern of diversity of the whole collection. The core collection was genotyped with 20 simple sequence repeat markers and a mini core set of 289 accessions was selected, which depicted the allele and genotype diversity of the core collection. The mungbean core and mini core collections plus their phenotypic and genotypic data are available for distribution to breeders. It is expected that these collections will enhance the access to biodiverse mungbean germplasm for breeding.

Synthesis and Plasmonic Understanding of Core/Satellite and Core Shell Nanostructures

Science.gov (United States)

Ruan, Qifeng

Localized surface plasmon resonance, which stems from the collective oscillations of conduction-band electrons, endows Au nanocrystals with unique optical properties. Au nanocrystals possess extremely large scattering/absorption cross-sections and enhanced local electromagnetic field, both of which are synthetically tunable. Moreover, when Au nanocrystals are closely placed or hybridized with semiconductors, the coupling and interaction between the individual components bring about more fascinating phenomena and promising applications, including plasmon-enhanced spectroscopies, solar energy harvesting, and cancer therapy. The continuous development in the field of plasmonics calls for further advancements in the preparation of high-quality plasmonic nanocrystals, the facile construction of hybrid plasmonic nanostructures with desired functionalities, as well as deeper understanding and efficient utilization of the interaction between plasmonic nanocrystals and semiconductor components. In this thesis, I developed a seed-mediated growth method for producing size-controlled Au nanospheres with high monodispersity and assembled Au nanospheres of different sizes into core/satellite nanostructures for enhancing Raman signals. For investigating the interactions between Au nanocrystals and semiconductors, I first prepared (Au core) (TiO2 shell) nanostructures, and then studied their synthetically controlled plasmonic properties and light-harvesting applications. Au nanocrystals with spherical shapes are desirable in plasmon-coupled systems owing to their high geometrical symmetry, which facilitates the analysis of electrodynamic responses in a classical electromagnetic framework and the investigation of quantum tunneling and nonlocal effects. I prepared remarkably uniform Au nanospheres with diameters ranging from 20 nm to 220 nm using a simple seed-mediated growth method associated with mild oxidation. Core/satellite nanostructures were assembled out of differently sized

Accelerator driven sub-critical core

Science.gov (United States)

McIntyre, Peter M; Sattarov, Akhdiyor

2015-03-17

Systems and methods for operating an accelerator driven sub-critical core. In one embodiment, a fission power generator includes a sub-critical core and a plurality of proton beam generators. Each of the proton beam generators is configured to concurrently provide a proton beam into a different area of the sub-critical core. Each proton beam scatters neutrons within the sub-critical core. The plurality of proton beam generators provides aggregate power to the sub-critical core, via the proton beams, to scatter neutrons sufficient to initiate fission in the sub-critical core.

In-core flow rate distribution measurement test of the JOYO irradiation core

International Nuclear Information System (INIS)

Suzuki, Toshihiro; Isozaki, Kazunori; Suzuki, Soju

1996-01-01

A flow rate distribution measurement test was carried out for the JOYO irradiation core (the MK-II core) after the 29th duty cycle operation. The main object of the test is to confirm the proper flow rate distribution at the final phase of the MK-II core. The each flow rate at the outlet of subassemblies was measured by the permanent magnetic flowmeter inserted avail of fuel exchange hole in the rotating plug. This is third test in the MK-II core, after 10 years absence from the final test (1985). Total of 550 subassemblies were exchanged and accumulated reactor operation time reached up to 38,000 hours from the previous test. As a conclusion, it confirmed that the flow rate distribution has been kept suitable in the final phase of the MK-II core. (author)

Models of the earth's core

International Nuclear Information System (INIS)

Stevenson, D.J.

1981-01-01

The combination of seismology, high pressure experiment and theory, geomagnetism, fluid dynamics, and current views of terrestrial planetary evolution lead to strong constraints on core models. The synthesis presented here is devoted to the defense of the following properties: (1) core formation was contemporaneous with earth accretion; (2) the outer, liquid core is predominately iron but cannot be purely iron; (3) the inner core-outer core boundary represents a thermodynamic equilibrium between a liquid alloys and a predominanately iron solid; (4) thermodynamic and transport properties of outer core can be estimated from liquid-state theories; and (5) the outer core is probably adiabatic and uniform in composition. None of these propositions are universally accepted by geophysicists. But, the intent of this paper is to present a coherent picture which explains most of the data with the fewest ad hoc assumptions. Areas in which future progress is both essential and likely are geo- and cosmochronology, seismological determinations of core structure, fluid dynamics of the core and mantle, and condensed matter physics

Models of the earth's core

Science.gov (United States)

Stevenson, D. J.

1981-01-01

Combined inferences from seismology, high-pressure experiment and theory, geomagnetism, fluid dynamics, and current views of terrestrial planetary evolution lead to models of the earth's core with five basic properties. These are that core formation was contemporaneous with earth accretion; the core is not in chemical equilibrium with the mantle; the outer core is a fluid iron alloy containing significant quantities of lighter elements and is probably almost adiabatic and compositionally uniform; the more iron-rich inner solid core is a consequence of partial freezing of the outer core, and the energy release from this process sustains the earth's magnetic field; and the thermodynamic properties of the core are well constrained by the application of liquid-state theory to seismic and labroatory data.

Study of the mechanism of clamping and detachment of a core sample by core lever lifters

Energy Technology Data Exchange (ETDEWEB)

Barabashkin, I I; Mizyakin, V M; Nikitin, S V

1981-01-01

Geometric dimensions of the basic elements of a core lifter should be determined depending on the clamping conditions. The changes should be determined depending on the conditions of the core sample diameter, critical angle between the lever and the core samples in the necessary depth of submersion of the contact edge of the lever into its surface. The core lifter KTsRZ-80 with eccentric core reception makes it possible to arrange more efficiently the core removing elements on the edge of the band. The use of the core lifters with eccentric plan of arrangement of the levers and their optimal length increases the removal of the core sample.

Inflation targeting and core inflation

OpenAIRE

Julie Smith

2005-01-01

This paper examines the interaction of core inflation and inflation targeting as a monetary policy regime. Interest in core inflation has grown because of inflation targeting. Core inflation is defined in numerous ways giving rise to many potential measures; this paper defines core inflation as the best forecaster of inflation. A cross-country study finds before the start of inflation targeting, but not after, core inflation differs between non-inflation targeters and inflation targeters. Thr...

Collapsing stellar cores and supernovae

Energy Technology Data Exchange (ETDEWEB)

Epstein, R J [Nordisk Inst. for Teoretisk Atomfysik, Copenhagen (Denmark); Noorgaard, H [Nordisk Inst. for Teoretisk Atomfysik, Copenhagen (Denmark); Chicago Univ., IL (USA). Enrico Fermi Inst.); Bond, J R [Niels Bohr Institutet, Copenhagen (Denmark); California Inst. of Tech., Pasadena (USA). W.K. Kellogg Radiation Lab.)

1979-05-01

The evolution of a stellar core is studied during its final quasi-hydrostatic contraction. The core structure and the (poorly known) properties of neutron rich matter are parametrized to include most plausible cases. It is found that the density-temperature trajectory of the material in the central part of the core (the core-center) is insensitive to nearly all reasonable parameter variations. The central density at the onset of the dynamic phase of the collapse (when the core-center begins to fall away from the rest of the star) and the fraction of the emitted neutrinos which are trapped in the collapsing core-center depend quite sensitively on the properties of neutron rich matter. We estimate that the amount of energy Ecm which is imparted to the core-mantle by the neutrinos which escape from the imploded core-center can span a large range of values. For plausible choices of nuclear and model parameters Ecm can be large enough to yield a supernova event.

R and D on thermal hydraulics of core and core-bottom structure

International Nuclear Information System (INIS)

Inagaki, Yoshiyuki; Hino, Ryutaro; Kunitomi, Kazuhiko; Takase, Kazuyuki; Ioka, Ikuo; Maruyama, So

2004-01-01

Thermal hydraulic tests on the core and core-bottom structure of the high-temperature engineering test reactor (HTTR) were carried out with the helium engineering demonstration loop (HENDEL) under simulated reactor operating conditions. The HENDEL was composed of helium gas circulation loops, mother sections (M 1 and M 2 ) and adaptor section (A), and two test sections, i.e. the fuel stack test section (T 1 ) and in-core structure test section (T 2 ). In the T 1 test section simulating a fuel stack of the core, thermal and hydraulic performances of helium gas flowing through a fuel block were investigated for thermal design of the HTTR core. In the T 2 test section simulating the core-bottom structure, demonstration tests were performed to verify the structural integrity of graphite and metal components, seal performance against helium gas leakage among the graphite permanent blocks and thermal mixing performance of helium gas. The above test results in the T 1 and T 2 test sections were applied to the detailed design and licensing works of the HTTR and the HENDEL-loop was dismantled in 1999

Information on web-site of the State protection of nature

International Nuclear Information System (INIS)

Rajtar, R.

2005-01-01

Statna ochrana prirody SR (SOP SR - State protection of nature of the Slovak Republic) is professional organisation with all-Slovak operation, which operation is aimed on provision of professional activities for service of state administration in protection of nature and landscape. Structure of the SOP SR, their operation and information presented on the web site of the SOP SR (www.sopsr.sk) are described

PFGE standard operating procedures for Listeria monocytogenes: harmonizing the typing of food and clinical strains in Europe.

Science.gov (United States)

Michelon, Damien; Félix, Benjamin; Vingadassalon, Noemie; Mariet, Jean-François; Larsson, Jonas T; Møller-Nielsen, Eva; Roussel, Sophie

2015-03-01

Listeria monocytogenes is a foodborne pathogen responsible for a severe disease known as listeriosis. The European Centre for Disease Prevention and Control (ECDC) coordinates a network of national public health laboratories (NPHLs) in charge of typing clinical strains. In food, it is the European Union Reference Laboratory for L. monocytogenes (EURL Lm), which manages a network of National Reference Laboratories (NRLs). A pulsed-field gel electrophoresis (PFGE) standard operating procedure (EURL SOP) has been used routinely at the EURL Lm since 2007. The EURL Lm has recommended that NRLs use the EURL SOP, whereas the Statens Serum Institut (SSI), under contract for ECDC, requested that NPHLs use Halpins' SOP (HSOP) published in 2010 for the PulseNet USA network. An update of Halpins' SOP (uHSOP) was published in 2013. To facilitate the exchange of profiles among human and food European reference laboratories, it is crucial to ensure that the PFGE profiles obtained with these different SOPs are comparable. The aim here was to compare the EURL SOP with HSOP and uHSOP. The panel comprised 114 well-characterized SSI/EURL strains. All were characterized at the EURL using both the EURL SOP and uHSOP. Seventy of the 114 strains were also characterized at the SSI using HSOP. The EURL SOP and uHSOP produced indistinguishable combined (ApaI/AscI) profiles for the 114 strains tested. The EURL SOP and HSOP produced indistinguishable combined profiles for 69 of the 70 strains tested. One strain displayed for the AscI profile an additional low-intensity band at 184 kbp with HSOP. For this strain, SSI and EUR Lm had already observed the same profile from NPHLs and NRLs. However, this deviation is minor as it accounted for about 1% of all the 114 combined profiles. This study should facilitate the exchange of reproducible PFGE profiles among human and food reference laboratories.

78 FR 56174 - In-Core Thermocouples at Different Elevations and Radial Positions in Reactor Core

Science.gov (United States)

2013-09-12

... 52 [Docket No. PRM-50-105; NRC-2012-0056] In-Core Thermocouples at Different Elevations and Radial Positions in Reactor Core AGENCY: Nuclear Regulatory Commission. ACTION: Petition for rulemaking; denial...-core thermocouples at different elevations and radial positions throughout the reactor core to enable...

IGCSE core mathematics

CERN Document Server

Wall, Terry

2013-01-01

Give your core level students the support and framework they require to get their best grades with this book dedicated to the core level content of the revised syllabus and written specifically to ensure a more appropriate pace. This title has been written for Core content of the revised Cambridge IGCSE Mathematics (0580) syllabus for first teaching from 2013. ? Gives students the practice they require to deepen their understanding through plenty of practice questions. ? Consolidates learning with unique digital resources on the CD, included free with every book. We are working with Cambridge

Replaceable LMFBR core components

International Nuclear Information System (INIS)

Evans, E.A.; Cunningham, G.W.

1976-01-01

Much progress has been made in understanding material and component performance in the high temperature, fast neutron environment of the LMFBR. Current data have provided strong assurance that the initial core component lifetime objectives of FFTF and CRBR can be met. At the same time, this knowledge translates directly into the need for improved core designs that utilize improved materials and advanced fuels required to meet objectives of low doubling times and extended core component lifetimes. An industrial base for the manufacture of quality core components has been developed in the US, and all procurements for the first two core equivalents for FFTF will be completed this year. However, the problem of fabricating recycled plutonium while dramatically reducing fabrication costs, minimizing personnel exposure, and protecting public health and safety must be addressed

Dual-core Itanium Processor

CERN Multimedia

2006-01-01

Intel’s first dual-core Itanium processor, code-named "Montecito" is a major release of Intel's Itanium 2 Processor Family, which implements the Intel Itanium architecture on a dual-core processor with two cores per die (integrated circuit). Itanium 2 is much more powerful than its predecessor. It has lower power consumption and thermal dissipation.

Core TuLiP

NARCIS (Netherlands)

Czenko, M.R.; Etalle, Sandro

2007-01-01

We propose CoreTuLiP - the core of a trust management language based on Logic Programming. CoreTuLiP is based on a subset of moded logic programming, but enjoys the features of TM languages such as RT; in particular clauses are issued by different authorities and stored in a distributed manner. We

Beyond the Core: Peer Observation Brings Common Core to Vocational and Electives Classes

Science.gov (United States)

Thurber Rasmussen, Harriette

2014-01-01

This article describes how a Washington State School District increased professional learning around the Common Core State Standards. The challenge was how to establish a way for career and technical education and electives teachers to learn and apply Common Core in their classes. Weaving Common Core literacy standards into vocational and…

FBR type reactor core

International Nuclear Information System (INIS)

Tamiya, Tadashi; Kawashima, Katsuyuki; Fujimura, Koji; Murakami, Tomoko.

1995-01-01

Neutron reflectors are disposed at the periphery of a reactor core fuel region and a blanket region, and a neutron shielding region is disposed at the periphery of them. The neutron reflector has a hollow duct structure having a sealed upper portion, a lower portion opened to cooling water, in which a gas and coolants separately sealed in the inside thereof. A driving pressure of a primary recycling pump is lowered upon reduction of coolant flow rate, then the liquid level of coolants in the neutron reflector is lowered due to imbalance between the driving pressure and a gas pressure, so that coolants having an effect as a reflector are eliminated from the outer circumference of the reactor core. Therefore, the amount of neutrons leaking from the reactor core is increased, and negative reactivity is charged to the reactor core. The negative reactivity of the neutron reflector is made greater than a power compensation reactivity. Since this enables reactor scram by using an inherent performance of the reactor core, the reactor core safety of an LMFBR-type reactor can be improved. (I.N.)

Reactor core

International Nuclear Information System (INIS)

Matsuura, Tetsuaki; Nomura, Teiji; Tokunaga, Kensuke; Okuda, Shin-ichi

1990-01-01

Fuel assemblies in the portions where the gradient of fast neutron fluxes between two opposing faces of a channel box is great are kept loaded at the outermost peripheral position of the reactor core also in the second operation cycle in the order to prevent interference between a control rod and the channel box due to bending deformation of the channel box. Further, the fuel assemblies in the second row from the outer most periphery in the first operation cycle are also kept loaded at the second row in the second operation cycle. Since the gradient of the fast neutrons in the reactor core is especially great at the outer circumference of the reactor core, the channel box at the outer circumference is bent such that the surface facing to the center of the reactor core is convexed and the channel box in the second row is also bent to the identical direction, the insertion of the control rod is not interfered. Further, if the positions for the fuels at the outermost periphery and the fuels in the second row are not altered in the second operation cycle, the gaps are not reduced to prevent the interference between the control rod and the channel box. (N.H.)

Core concepts for ''zero-sodium-void-worth core'' in metal fuelled fast reactor

International Nuclear Information System (INIS)

Chang, Y.I.; Hill, R.N.; Fujita, E.K.; Wade, D.C.; Kumaoka, Y.; Suzuki, M.; Kawashima, M.; Nakagawa, H.

1991-01-01

Core design options to reduce the sodium void worth in metal fueled LMRs are investigated. Two core designs which achieve a zero sodium void worth are analyzed in detail. The first design is a ''pancaked'' and annular core with enhanced transuranic burning capabilities; the high leakage in this design yields a low breeding ratio and small void worth. The second design is an axially multilayered annular core which is fissile self-sufficient; in this design, the upper and lower core regions are neutronically decoupled for reduced void worth while fissile self-sufficiency is achieved using internal axial blankets plus external radial and axial blanket zones. The neutronic performance characteristics of these low void worth designs are assessed here; their passive safety properties are discussed in a companion paper. 16 refs., 2 figs., 3 tabs

Core concepts for 'zero-sodium-void-worth core' in metal fuelled fast reactor

International Nuclear Information System (INIS)

Chang, Y.I.; Hill, R.N.; Fujita, E.K.; Wade, D.C.; Kumaoka, Y.; Suzuki, M.; Kawashima, M.; Nakagawa, H.

1991-01-01

Core design options to reduce the sodium void worth in metal fuelled LMRs are investigated. Two core designs which achieve a zero sodium void worth are analyzed in detail. The first design is a 'pancaked' and annular core with enhanced transuranic burning capabilities; the high leakage in this design yields a low breeding ratio and small void worth. The second design is an axially multilayered annular core which is fissile self-sufficient; in this design, the upper and lower core regions are neutronically decoupled for reduced void worth while fissile self-sufficiency is achieved using internal axial blankets plus external radial and axial blanket-zones. The neutronic performance characteristics of these low void worth designs are assessed here; their passive safety properties are discussed in a companion paper. (author)

On-line generation of core monitoring power distribution in the SCOMS couppled with core design code

International Nuclear Information System (INIS)

Lee, K. B.; Kim, K. K.; In, W. K.; Ji, S. K.; Jang, M. H.

2002-01-01

The paper provides the description of the methodology and main program module of power distribution calculation of SCOMS(SMART COre Monitoring System). The simulation results of the SMART core using the developed SCOMS are included. The planar radial peaking factor(Fxy) is relatively high in SMART core because control banks are inserted to the core at normal operation. If the conventional core monitoring method is adapted to SMART, highly skewed planar radial peaking factor Fxy yields an excessive conservatism and reduces the operation margin. In addition to this, the error of the core monitoring would be enlarged and thus operating margin would be degraded, because it is impossible to precalculate the core monitoring constants for all the control banks configurations taking into account the operation history in the design stage. To get rid of these drawbacks in the conventional power distribution calculation methodology, new methodology to calculate the three dimensional power distribution is developed. Core monitoring constants are calculated with the core design code (MASTER) which is on-line coupled with SCOMS. Three dimensional (3D) power distribution and the several peaking factors are calculated using the in-core detector signals and core monitoring constant provided at real time. Developed methodology is applied to the SMART core and the various core states are simulated. Based on the simulation results, it is founded that the three dimensional peaking factor to calculate the Linear Power Density and the pseudo hot-pin axial power distribution to calculate the Departure Nucleate Boiling Ratio show the more conservative values than those of the best-estimated core design code, and SCOMS adapted developed methodology can secures the more operation margin than the conventional methodology

A modularized framework for sales and operations planning with focus on process industries

Directory of Open Access Journals (Sweden)

Sayeh Noroozi

2016-01-01

Full Text Available This paper suggests a modularized sales and operations planning (S&OP framework, consisting of content and process. The framework’s content is based on a typology of decoupling points in which the effect of decoupling points on the decision variables in S&OP is studied. The framework’s process takes a step back and addresses the need for a more elaborate design to precede the operational use of S&OP content for different production contexts. The framework supports both process industries (PIs and discrete manufacturing industries (DIs, and recognizes their specific requirements and reflects them in their S&OP. The differentiating characteristics of PIs and DIs are emphasized through three different decoupling points, namely: discretization decoupling point, control mode decoupling point, and customer order decoupling point. The suggested framework aims to fill the gap in the literature regarding the lack of aggregate planning processes that match the PIs’ specific requirements by reflecting the differentiating characteristics of PIs in S&OP.

Perfectionism and performance expectations at university: Does gender still matter?

Directory of Open Access Journals (Sweden)

Hala K. Hassan

2012-12-01

Full Text Available The present study examines the relationship between the perfectionist orientation and performance expectations at university and whether gender moderates this relationship. One-hundred first year university students responded to two subscales from the Multidimensional Perfectionism Scale (MPS-HF: the Self-Oriented Perfectionism (SOP subscale and the Socially Prescribed Perfectionism (SPP subscale. Results of the study showed that SOP and SPP correlated positively. Students, regardless of gender, demonstrated higher levels of SOP than SPP. Both SOP and SPP correlated positively with performance expectations. Self- oriented perfectionists and high perfectionists reported significantly higher performance expectations than socially oriented perfectionists and non-perfectionists. There were no significant differences between socially oriented perfectionists and non-perfectionists nor were there significant differences between self-oriented perfectionists and high perfectionists in performance expectations. Gender did not moderate the effect of types of perfectionism on performance expectations. There were no gender differences in SOP, SPP, or performance expectations

Comparison of different eigensolvers for calculating vibrational spectra using low-rank, sum-of-product basis functions

Science.gov (United States)

Leclerc, Arnaud; Thomas, Phillip S.; Carrington, Tucker

2017-08-01

Vibrational spectra and wavefunctions of polyatomic molecules can be calculated at low memory cost using low-rank sum-of-product (SOP) decompositions to represent basis functions generated using an iterative eigensolver. Using a SOP tensor format does not determine the iterative eigensolver. The choice of the interative eigensolver is limited by the need to restrict the rank of the SOP basis functions at every stage of the calculation. We have adapted, implemented and compared different reduced-rank algorithms based on standard iterative methods (block-Davidson algorithm, Chebyshev iteration) to calculate vibrational energy levels and wavefunctions of the 12-dimensional acetonitrile molecule. The effect of using low-rank SOP basis functions on the different methods is analysed and the numerical results are compared with those obtained with the reduced rank block power method. Relative merits of the different algorithms are presented, showing that the advantage of using a more sophisticated method, although mitigated by the use of reduced-rank SOP functions, is noticeable in terms of CPU time.

Maximum stellar iron core mass

Indian Academy of Sciences (India)

An analytical method of estimating the mass of a stellar iron core, just prior to core collapse, is described in this paper. The method employed depends, in part, upon an estimate of the true relativistic mass increase experienced by electrons within a highly compressed iron core, just prior to core collapse, and is significantly ...

Wavelength-Dependence of Inter-Core Crosstalk in Homogeneous Multi-Core Fibers

DEFF Research Database (Denmark)

Ye, Feihong; Saitoh, Kunimasa; Takenaga, Katsuhiro

2016-01-01

The wavelength dependence of inter-core crosstalk in homogeneous multi-core fibers (MCFs) is investigated, and the corresponding analytical expressions are derived. The derived analytical expressions can be used to determine the crosstalk at any wavelength necessary for designing future MCF...

Core/shell particles containing liquid cores : morphology prediction, synthesis and characterization

NARCIS (Netherlands)

Zyl, van A.J.P.; Sanderson, R.D.; Wet-Roos, de D.; Klumperman, B.

2003-01-01

The ability to synthesize core/shell particles with distinct geometries is becoming increasingly important due to their potential applications. In this study structured particles with liquid cores and polymeric shells were synthesized by an in situ miniemulsion polymerization reaction. The resulting

SCTF Core-I test results

International Nuclear Information System (INIS)

Adachi, Hiromichi; Sudo, Yukio; Iwamura, Takamichi; Osakabe, Masahiro; Ohnuki, Akira; Hirano, Kemmei

1982-07-01

The Slab Core Test Facility (SCTF) of Japan Atomic Energy Research Institute (JAERI) was constructed to investigate two-dimensional thermohydrodynamics in the core and the communication in fluid behavior between the core and the upper plenum during the last part of blowdown, refill and reflood phases of a posturated loss-of-coolant accident (LOCA) of a pressurized water reactor (PWR). In the present report, effects of system pressure on reflooding phenomena shall be discussed based on the data of Tests S1-SH2, S1-01 and S1-02 which are the parameteris tests for system pressure effects belonging to the SCTF Core-I forced flooding test series. Major items discussed in this report are (1) hydrodynamic behavior in the system, (2) core thermal behavior, (3) core heat transfer and (4) two-dimensional hydrodynamic behavior in the pressure vessel including the core. (author)

Windscale pile core surveys

International Nuclear Information System (INIS)

Curtis, R.F.; Mathews, R.F.

1996-01-01

The two Windscale Piles were closed down, defueled as far as possible and mothballed for thirty years following a fire in the core of Pile 1 in 1957 resulting from the spontaneous release of stored Wigner energy in the graphite moderator. Decommissioning of the reactors commenced in 1987 and has reached the stage where the condition of both cores needs to be determined. To this end, non-intrusive and intrusive surveys and sampling of the cores have been planned and partly implemented. The objectives for each Pile differ slightly. The location and quantity of fuel remaining in the damaged core of Pile 1 needed to be established, whereas the removal of all fuel from Pile 2 needed to be confirmed. In Pile 1, the possible existence of a void in the core is to be explored and in Pile 2, the level of Wigner energy remaining required to be quantified. Levels of radioactivity in both cores needed to be measured. The planning of the surveys is described including strategy, design, safety case preparation and the remote handling and viewing equipment required to carry out the inspection, sampling and monitoring work. The results from the completed non-intrusive survey of Pile 2 are summarised. They confirm that the core is empty and the graphite is in good condition. The survey of Pile 1 has just started. (UK)

Tracking the sleep onset process: an empirical model of behavioral and physiological dynamics.

Directory of Open Access Journals (Sweden)

Michael J Prerau

2014-10-01

Full Text Available The sleep onset process (SOP is a dynamic process correlated with a multitude of behavioral and physiological markers. A principled analysis of the SOP can serve as a foundation for answering questions of fundamental importance in basic neuroscience and sleep medicine. Unfortunately, current methods for analyzing the SOP fail to account for the overwhelming evidence that the wake/sleep transition is governed by continuous, dynamic physiological processes. Instead, current practices coarsely discretize sleep both in terms of state, where it is viewed as a binary (wake or sleep process, and in time, where it is viewed as a single time point derived from subjectively scored stages in 30-second epochs, effectively eliminating SOP dynamics from the analysis. These methods also fail to integrate information from both behavioral and physiological data. It is thus imperative to resolve the mismatch between the physiological evidence and analysis methodologies. In this paper, we develop a statistically and physiologically principled dynamic framework and empirical SOP model, combining simultaneously-recorded physiological measurements with behavioral data from a novel breathing task requiring no arousing external sensory stimuli. We fit the model using data from healthy subjects, and estimate the instantaneous probability that a subject is awake during the SOP. The model successfully tracked physiological and behavioral dynamics for individual nights, and significantly outperformed the instantaneous transition models implicit in clinical definitions of sleep onset. Our framework also provides a principled means for cross-subject data alignment as a function of wake probability, allowing us to characterize and compare SOP dynamics across different populations. This analysis enabled us to quantitatively compare the EEG of subjects showing reduced alpha power with the remaining subjects at identical response probabilities. Thus, by incorporating both

Core body temperature in obesity.

Science.gov (United States)

Heikens, Marc J; Gorbach, Alexander M; Eden, Henry S; Savastano, David M; Chen, Kong Y; Skarulis, Monica C; Yanovski, Jack A

2011-05-01

A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. In study 1, nonobese [body mass index (BMI; in kg/m(2)) temperature-sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18-25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for ≥48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis. Mean (±SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 ± 0.03°C compared with 36.89 ± 0.03°C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature ≈0.23°C greater than that of men (36.99 ± 0.03°C compared with 36.76 ± 0.03°C; P body temperature. It may be necessary to study individuals with function-altering mutations in core temperature-regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500.

Winning Cores in Parity Games

DEFF Research Database (Denmark)

Vester, Steen

2016-01-01

We introduce the novel notion of winning cores in parity games and develop a deterministic polynomial-time under-approximation algorithm for solving parity games based on winning core approximation. Underlying this algorithm are a number properties about winning cores which are interesting...... in their own right. In particular, we show that the winning core and the winning region for a player in a parity game are equivalently empty. Moreover, the winning core contains all fatal attractors but is not necessarily a dominion itself. Experimental results are very positive both with respect to quality...

Hollow-Core Fiber Lamp

Science.gov (United States)

Yi, Lin (Inventor); Tjoelker, Robert L. (Inventor); Burt, Eric A. (Inventor); Huang, Shouhua (Inventor)

2016-01-01

Hollow-core capillary discharge lamps on the millimeter or sub-millimeter scale are provided. The hollow-core capillary discharge lamps achieve an increased light intensity ratio between 194 millimeters (useful) and 254 millimeters (useless) light than conventional lamps. The capillary discharge lamps may include a cone to increase light output. Hollow-core photonic crystal fiber (HCPCF) may also be used.

Organizational Assessment of Shelter Outreach Plus

National Research Council Canada - National Science Library

Fisher, Jeffrey

2003-01-01

.... The report chronicles the study's findings with the hope and expectation of improving the working environment of SOP employees, improving organizational performance, and enhancing SOP's stewardship...

Optimal core acquisition and remanufacturing policies under uncertain core quality fractions

NARCIS (Netherlands)

Teunter, R.H.; Flapper, S.D.P.

2011-01-01

Cores acquired by a remanufacturer are typically highly variable in quality. Even if the expected fractions of the various quality levels are known, then the exact fractions when acquiring cores are still uncertain. Our model incorporates this uncertainty in determining optimal acquisition decisions

Heterogeneous gas core reactor

International Nuclear Information System (INIS)

Han, K.I.

1977-01-01

Preliminary investigations of a heterogeneous gas core reactor (HGCR) concept suggest that this potential power reactor offers distinct advantages over other existing or conceptual reactor power plants. One of the most favorable features of the HGCR is the flexibility of the power producing system which allows it to be efficiently designed to conform to a desired optimum condition without major conceptual changes. The arrangement of bundles of moderator/coolant channels in a fissionable gas or mixture of gases makes a truly heterogeneous nuclear reactor core. It is this full heterogeneity for a gas-fueled reactor core which accounts for the novelty of the heterogeneous gas core reactor concept and leads to noted significant advantages over previous gas core systems with respect to neutron and fuel economy, power density, and heat transfer characteristics. The purpose of this work is to provide an insight into the design, operating characteristics, and safety of a heterogeneous gas core reactor system. The studies consist mainly of neutronic, energetic and kinetic analyses of the power producing and conversion systems as a preliminary assessment of the heterogeneous gas core reactor concept and basic design. The results of the conducted research indicate a high potential for the heterogeneous gas core reactor system as an electrical power generating unit (either large or small), with an overall efficiency as high as 40 to 45%. The HGCR system is found to be stable and safe, under the conditions imposed upon the analyses conducted in this work, due to the inherent safety of ann expanding gaseous fuel and the intrinsic feedback effects of the gas and water coolant

Reactor-core-reactivity control device

International Nuclear Information System (INIS)

Miura, Teruo; Sakuranaga, Tomonobu.

1983-01-01

Purpose: To improve the reactor safety upon failures of control rod drives by adapting a control rod not to drop out accidentally from the reactor core but be inserted into the reactor core. Constitution: The control rod is entered or extracted as usual from the bottom of the pressure vessel. A space is provided above the reactor core within the pressure vessel, in which the moving scope of the control rod is set between the space above the reactor core and the reactor core. That is, the control rod is situated above the reactor core upon extraction thereof and, if an accident occurs to the control rod drive mechanisms to detach the control rod and the driving rod, the control rod falls gravitationally into the reactor core to improve the reactor safety. In addition, since the speed limiter is no more required to the control rod, the driving force can be decreased to reduce the size of the rod drive mechanisms. (Ikeda, J.)

HOW STARLESS ARE STARLESS CORES?

International Nuclear Information System (INIS)

Schnee, Scott; Friesen, Rachel; Di Francesco, James; Johnstone, Doug; Enoch, Melissa; Sadavoy, Sarah

2012-01-01

In this paper, we present the results of Combined Array for Research in Millimeter-wave Astronomy continuum and spectral line observations of the dense core Per-Bolo 45. Although this core has previously been classified as starless, we find evidence for an outflow and conclude that Per-Bolo 45 is actually an embedded, low-luminosity protostar. We discuss the impact of newly discovered, low-luminosity, embedded objects in the Perseus molecular cloud on starless core and protostar lifetimes. We estimate that the starless core lifetime has been overestimated by 4%-18% and the Class 0/I protostellar lifetime has been underestimated by 5%-20%. Given the relatively large systematic uncertainties involved in these calculations, variations on the order of 10% do not significantly change either core lifetimes or the expected protostellar luminosity function. Finally, we suggest that high-resolution (sub)millimeter surveys of known cores lacking near-infrared and mid-infrared emission are necessary to make an accurate census of starless cores.

Core Design Concept and Core Structural Material Development for a Prototype SFR

International Nuclear Information System (INIS)

Chang, Jinwook

2013-01-01

• Core design Concept: – Initial core is Uranium metal fueled core, then it will evolve into TRU core; – Tight pressure drop constraint lowers power density; – Trade-off studies with relaxed pressure drop constraint (~0.4MPa) are on-going; – Major feature will be finalized this year. • KAERI is developing advanced cladding for high burnup fuel in Ptototype SFR: – Advanced cladding materials are now developing, which shows superior high temperature mechanical property to the conventional material; – Processing technologies related to tube making process are now developed to enhance high temperature mechanical propertyl – Preliminary HT9 cladding tube was manufactured and out-of pile mechanical properties were evaluated. Advanced cladding tube is now being developed and being prepared for irradiation test

DENSE CORES IN THE PIPE NEBULA: AN IMPROVED CORE MASS FUNCTION

International Nuclear Information System (INIS)

Rathborne, J. M.; Lada, C. J.; Muench, A. A.; Alves, J. F.; Kainulainen, J.; Lombardi, M.

2009-01-01

In this paper, we derive an improved core mass function (CMF) for the Pipe Nebula from a detailed comparison between measurements of visual extinction and molecular-line emission. We have compiled a refined sample of 201 dense cores toward the Pipe Nebula using a two-dimensional threshold identification algorithm informed by recent simulations of dense core populations. Measurements of radial velocities using complimentary C 18 O (1-0) observations enable us to cull out from this sample those 43 extinction peaks that are either not associated with dense gas or are not physically associated with the Pipe Nebula. Moreover, we use the derived C 18 O central velocities to differentiate between single cores with internal structure and blends of two or more physically distinct cores, superposed along the same line of sight. We then are able to produce a more robust dense core sample for future follow-up studies and a more reliable CMF than was possible previously. We confirm earlier indications that the CMF for the Pipe Nebula departs from a single power-law-like form with a break or knee at M ∼ 2.7 ± 1.3 M sun . Moreover, we also confirm that the CMF exhibits a similar shape to the stellar initial mass function (IMF), but is scaled to higher masses by a factor of ∼4.5. We interpret this difference in scaling to be a measure of the star formation efficiency (22% ± 8%). This supports earlier suggestions that the stellar IMF may originate more or less directly from the CMF.

Lunar Core and Tides

Science.gov (United States)

Williams, J. G.; Boggs, D. H.; Ratcliff, J. T.

2004-01-01

Variations in rotation and orientation of the Moon are sensitive to solid-body tidal dissipation, dissipation due to relative motion at the fluid-core/solid-mantle boundary, and tidal Love number k2 [1,2]. There is weaker sensitivity to flattening of the core-mantle boundary (CMB) [2,3,4] and fluid core moment of inertia [1]. Accurate Lunar Laser Ranging (LLR) measurements of the distance from observatories on the Earth to four retroreflector arrays on the Moon are sensitive to lunar rotation and orientation variations and tidal displacements. Past solutions using the LLR data have given results for dissipation due to solid-body tides and fluid core [1] plus Love number [1-5]. Detection of CMB flattening, which in the past has been marginal but improving [3,4,5], now seems significant. Direct detection of the core moment has not yet been achieved.

Electromagnetically driven westward drift and inner-core superrotation in Earth’s core

OpenAIRE

Livermore, Philip W.; Hollerbach, Rainer; Jackson, Andrew

2013-01-01

Seismic probing of the earth’s deep interior has shown that the inner core, the solid core of our planet, rotates slightly faster (i.e., eastward) than the rest of the earth. Quite independently, observations of the geomagnetic field provide evidence of westward-drifting features at the edge of the liquid outer core. This paper describes a computer model that suggests that the geomagnetic field itself may provide a link between them: The associated electromagnetic torque currently is westward...

Meltdown reactor core cooling facility

International Nuclear Information System (INIS)

Matsuoka, Tsuyoshi.

1992-01-01

The meltdown reactor core cooling facility comprises a meltdown reactor core cooling tank, a cooling water storage tank situates at a position higher than the meltdown reactor core cooling tank, an upper pipeline connecting the upper portions of the both of the tanks and a lower pipeline connecting the lower portions of them. Upon occurrence of reactor core meltdown, a high temperature meltdown reactor core is dropped on the cooling tank to partially melt the tank and form a hole, from which cooling water is flown out. Since the water source of the cooling water is the cooling water storage tank, a great amount of cooling water is further dropped and supplied and the reactor core is submerged and cooled by natural convection for a long period of time. Further, when the lump of the meltdown reactor core is small and the perforated hole of the meltdown reactor cooling tank is small, cooling water is boiled by the high temperature lump intruding into the meltdown reactor core cooling tank and blown out from the upper pipeline to the cooling water storage tank to supply cooling water from the lower pipeline to the meltdown reactor core cooling tank. Since it is constituted only with simple static facilities, the facility can be simplified to attain improvement of reliability. (N.H.)

Protective Effects of Soy Oligopeptides in Ultraviolet B-Induced Acute Photodamage of Human Skin

Directory of Open Access Journals (Sweden)

Bing-rong Zhou

2016-01-01

Full Text Available Aim. We explored the effects of soy oligopeptides (SOP in ultraviolet B- (UVB- induced acute photodamage of human skin in vivo and foreskin ex vivo. Methods. We irradiated the forearm with 1.5 minimal erythemal dose (MED of UVB for 3 consecutive days, establishing acute photodamage of skin, and topically applied SOP. Erythema index (EI, melanin index, stratum corneum hydration, and transepidermal water loss were measured by using Multiprobe Adapter 9 device. We irradiated foreskin ex vivo with the same dose of UVB (180 mJ/cm2 for 3 consecutive days and topically applied SOP. Sunburn cells were detected by using hematoxylin and eosin staining. Apoptotic cells were detected by using terminal deoxynucleotidyl transferase dUTP nick end labeling assay. Cyclobutane pyrimidine dimers (CPDs, p53 protein, Bax protein, and Bcl-2 protein were detected by using immunohistochemical staining. Results. Compared with UVB group, UVB-irradiated skin with topically applied SOP showed significantly decreased EI. Compared with UVB group, topical SOP significantly increased Bcl-2 protein expression and decreased CPDs-positive cells, sunburn cells, apoptotic cells, p53 protein expression, and Bax protein expressions in the epidermis of UVB-irradiated foreskin. Conclusion. Our study demonstrated that topical SOP can protect human skin against UVB-induced photodamage.

Core Activities Program. TMI-2 Core Receipt and Storage Project Plan

International Nuclear Information System (INIS)

Ayers, A.L. Jr.

1984-12-01

The TMI-2 Core Receipt and Storage Project is funded by the US Department of Energy and managed by the Technical Support Branch of EG and G Idaho, Inc. at the Idaho National Engineering Laboratory (INEL). As part of the Core Activities Program, this project will include: (a) preparations for receipt and storage of the Three Mile Island Unit 2 core debris at INEL; and (b) receipt and storage operations. This document outlines procedures; project management; safety, environment, and quality; safeguards and security; deliverables; and cost and schedule for the receipt and storage activities at INEL

Molten salt reactors: reactor cores

International Nuclear Information System (INIS)

1983-01-01

In this critical analysis of the MSBR I project are examined the problems concerning the reactor core. Advantages of breeding depend essentially upon solutions to technological problems like continuous reprocessing or graphite behavior under neutron irradiation. Graphite deformation, moderator unloading, control rods and core instrumentation require more studies. Neutronics of the core, influence of core geometry and salt composition, fuel evolution, and thermohydraulics are reviewed [fr

Core losses of a permanent magnet synchronous motor with an amorphous stator core under inverter and sinusoidal excitations

Science.gov (United States)

Yao, Atsushi; Sugimoto, Takaya; Odawara, Shunya; Fujisaki, Keisuke

2018-05-01

We report core loss properties of permanent magnet synchronous motors (PMSM) with amorphous magnetic materials (AMM) core under inverter and sinusoidal excitations. To discuss the core loss properties of AMM core, a comparison with non-oriented (NO) core is also performed. In addition, based on both experiments and numerical simulations, we estimate higher (time and space) harmonic components of the core losses under inverter and sinusoidal excitations. The core losses of PMSM are reduced by about 59% using AMM stator core instead of NO core under sinusoidal excitation. We show that the average decrease obtained by using AMM instead of NO in the stator core is about 94% in time harmonic components.

Core losses of a permanent magnet synchronous motor with an amorphous stator core under inverter and sinusoidal excitations

Directory of Open Access Journals (Sweden)

Atsushi Yao

2018-05-01

Full Text Available We report core loss properties of permanent magnet synchronous motors (PMSM with amorphous magnetic materials (AMM core under inverter and sinusoidal excitations. To discuss the core loss properties of AMM core, a comparison with non-oriented (NO core is also performed. In addition, based on both experiments and numerical simulations, we estimate higher (time and space harmonic components of the core losses under inverter and sinusoidal excitations. The core losses of PMSM are reduced by about 59% using AMM stator core instead of NO core under sinusoidal excitation. We show that the average decrease obtained by using AMM instead of NO in the stator core is about 94% in time harmonic components.

Drilling history core hole DC-8

International Nuclear Information System (INIS)

1978-10-01

Core hole DC-8 was completed in August, 1978 by Boyles Brothers Drilling Company, Spokane, Washington, under subcontract to Fenix and Scission, Inc. The hole was cored for the US Department of Energy and the Rockwell Hanford Operations' Basalt Waste Isolation Program. Fenix and Scisson, Inc. furnished the engineering, daily supervision of the core drilling activities, and geologic core logging for hole DC-8. Core hole DC-8 is located on the Hanford Site near the Wye Barricade and 50 feet northwest of rotary hole DC-7. The Hanford Site vation coordinates for DC-8 are North 14,955.94 feet and West 14,861.92 coordinates for DC-8 are North 14,955.94 feet and West 14,861.92 mean sea level. The purpose of core hole DC-8 was to core drill vertically through the basalt and interbed units for stratigraphic depth determination and core collection, and to provide a borehole for hydrologic testing and cross-hole seismic shear and pressure wave velocity studies with rotary hole DC-7. The total depth of core hole DC-8 was 4100.5 feet. Core recovery exceeded 97 percent of the total footage cored

Drilling history core hole DC-8

Energy Technology Data Exchange (ETDEWEB)

1978-10-01

Core hole DC-8 was completed in August, 1978 by Boyles Brothers Drilling Company, Spokane, Washington, under subcontract to Fenix and Scission, Inc. The hole was cored for the US Department of Energy and the Rockwell Hanford Operations' Basalt Waste Isolation Program. Fenix and Scisson, Inc. furnished the engineering, daily supervision of the core drilling activities, and geologic core logging for hole DC-8. Core hole DC-8 is located on the Hanford Site near the Wye Barricade and 50 feet northwest of rotary hole DC-7. The Hanford Site vation coordinates for DC-8 are North 14,955.94 feet and West 14,861.92 coordinates for DC-8 are North 14,955.94 feet and West 14,861.92 mean sea level. The purpose of core hole DC-8 was to core drill vertically through the basalt and interbed units for stratigraphic depth determination and core collection, and to provide a borehole for hydrologic testing and cross-hole seismic shear and pressure wave velocity studies with rotary hole DC-7. The total depth of core hole DC-8 was 4100.5 feet. Core recovery exceeded 97 percent of the total footage cored.

Nitride stabilized core/shell nanoparticles

Science.gov (United States)

Kuttiyiel, Kurian Abraham; Sasaki, Kotaro; Adzic, Radoslav R.

2018-01-30

Nitride stabilized metal nanoparticles and methods for their manufacture are disclosed. In one embodiment the metal nanoparticles have a continuous and nonporous noble metal shell with a nitride-stabilized non-noble metal core. The nitride-stabilized core provides a stabilizing effect under high oxidizing conditions suppressing the noble metal dissolution during potential cycling. The nitride stabilized nanoparticles may be fabricated by a process in which a core is coated with a shell layer that encapsulates the entire core. Introduction of nitrogen into the core by annealing produces metal nitride(s) that are less susceptible to dissolution during potential cycling under high oxidizing conditions.

TMI-2 core examination plan

International Nuclear Information System (INIS)

Owen, D.E.; MacDonald, P.E.; Hobbins, R.R.; Ploggr, S.A.

1982-01-01

The Three Mile Island (TMI-2) core examination is divided into four stages: (1) before removing the head; (2) before removing the plenum; (3) during defueling; and (4) offsite examinations. Core examinations recommended during the first three stages are primarily devoted to documenting the post-accident condition of the core. The detailed analysis of core damage structures will be performed during offsite examinations at government and commercial hot cell facilities. The primary objectives of these examinations are to enhance the understanding of the degraded core accident sequence, to develop the technical bases for reactor regulations, and to improve LWR design and operation

Device for removal of oriented core

Energy Technology Data Exchange (ETDEWEB)

Shakhmalov, A.M.

1981-05-04

A device for removal of an oriented core, which contains an external core barrel, connected with a gear, a rock-crushing bit, nonrotary core-receiving pipe, and a core marker, placed in the core-receiving pipe and connected kinematically with the external core barrel and gear, is distinguished by the fact that in order to increase the accuracy of determination of the spatial orientation of the core the gear of the core barrel and the marker come in the form of an electric drill, and a magnetic compass witha remote-fix indicator is attached to its housing. The device is also distinguished by the fact that it is equipped with an auxillary marker positioned symmetrically with respect to the first one.

Synthesis of Au@Ag core-shell nanocubes containing varying shaped cores and their localized surface plasmon resonances.

Science.gov (United States)

Gong, Jianxiao; Zhou, Fei; Li, Zhiyuan; Tang, Zhiyong

2012-06-19

We have synthesized Au@Ag core-shell nanocubes containing Au cores with varying shapes and sizes through modified seed-mediated methods. Bromide ions are found to be crucial in the epitaxial growth of Ag atoms onto Au cores and in the formation of the shell's cubic shape. The Au@Ag core-shell nanocubes exhibit very abundant and distinct localized surface plasmon resonance (LSPR) properties, which are core-shape and size-dependent. With the help of theoretical calculation, the physical origin and the resonance mode profile of each LSPR peak are identified and studied. The core-shell nanocrystals with varying shaped cores offer a new rich category for LSPR control through the plasmonic coupling effect between core and shell materials.

Sensitivity of reactivity feedback due to core bowing in a metallic-fueled core

International Nuclear Information System (INIS)

Nakagawa, Masatoshi; Kawashima, Masatoshi; Endo, Hiroshi; Nishimura, Tomohiro

1991-01-01

A sensitivity study has been carried out on negative reactivity feedback caused by core bowing to assess the potential effectiveness of FBR passive safety features in regard to withstanding an anticipated transient without scram (ATWS). In the present study, an analysis has been carried to obtain the best material and geometrical conditions concerning the core restraint system out for several power to flow rates (P/F), up to 2.0 for a 300 MWe metallic-fueled core. From this study, it was clarified that the pad stiffness at an above core loading pads (ACLP) needs to be large enough to ensure negative reactivity feedback against ATWS. It was also clarified that there is an upper limit for the clearances between ducts at ACLP. A new concept, in regard to increasing the absolute value for negative reactivity feedback due to core bowing at ATWS, is proposed and discussed. (author)

Bypass Flow and Hot Spot Analysis for PMR200 Block-Core Design with Core Restraint Mechanism

International Nuclear Information System (INIS)

Lim, Hong Sik; Kim, Min Hwan

2009-01-01

The accurate prediction of local hot spot during normal operation is important to ensure core thermal margin in a very high temperature gas-cooled reactor because of production of its high temperature output. The active cooling of the reactor core determining local hot spot is strongly affected by core bypass flows through the inter-column gaps between graphite blocks and the cross gaps between two stacked fuel blocks. The bypass gap sizes vary during core life cycle by the thermal expansion at the elevated temperature and the shrinkage/swelling by fast neutron irradiation. This study is to investigate the impacts of the variation of bypass gaps during core life cycle as well as core restraint mechanism on the amount of bypass flow and thus maximum fuel temperature. The core thermo fluid analysis is performed using the GAMMA+ code for the PMR200 block-core design. For the analysis not only are some modeling features, developed for solid conduction and bypass flow, are implemented into the GAMMA+ code but also non-uniform bypass gap distribution taken from a tool calculating the thermal expansion and the shrinkage/swell of graphite during core life cycle under the design options with and without core restraint mechanism is used

Design considerations for a servo optical projection system

Science.gov (United States)

Nadalsky, Michael; Allen, Daniel; Bien, Joseph

1987-01-01

The present servooptical projection system (SOPS) furnishes 'out-the-window' scenery for a pilot-training flight simulator; attention is given to the parametric tradeoffs made in the SOPS' optical design, as well as to its mechanical packaging and the servonetwork performance of the unit as integrated into a research/training helicopter flight simulator. The final SOPS configuration is a function of scan head design, assembly modularity, image deterioration method, and focal lengths and relative apertures.

WNP-2 core model upgrade

International Nuclear Information System (INIS)

Golightly, C.E.; Ravindranath, T.K.; Belblidia, L.A.; O'Farrell, D.; Andersen, P.S.

2006-01-01

The paper describes the core model upgrade of the WNP-2 training simulator and the reasons for the upgrade. The core model as well as the interface with the rest of the simulator are briefly described . The paper also describes the procedure that will be used by WNP-2 to update the simulator core data after future core reloads. Results from the fully integrated simulator are presented. (author)

Operating principle of Soft Open Points for electrical distribution network operation

International Nuclear Information System (INIS)

Cao, Wanyu; Wu, Jianzhong; Jenkins, Nick; Wang, Chengshan; Green, Timothy

2016-01-01

Highlights: • Two control modes were developed for a B2B VSCs based SOP. • The SOP operating principle was investigated under various network conditions. • The performance of the SOP using two control modes was analyzed. - Abstract: Soft Open Points (SOPs) are power electronic devices installed in place of normally-open points in electrical power distribution networks. They are able to provide active power flow control, reactive power compensation and voltage regulation under normal network operating conditions, as well as fast fault isolation and supply restoration under abnormal conditions. Two control modes were developed for the operation of an SOP, using back-to-back voltage-source converters (VSCs). A power flow control mode with current control provides independent control of real and reactive power. A supply restoration mode with a voltage controller enables power supply to isolated loads due to network faults. The operating principle of the back-to-back VSCs based SOP was investigated under both normal and abnormal network operating conditions. Studies on a two-feeder medium-voltage distribution network showed the performance of the SOP under different network-operating conditions: normal, during a fault and post-fault supply restoration. During the change of network operating conditions, a mode switch method based on the phase locked loop controller was used to achieve the transitions between the two control modes. Hard transitions by a direct mode switching were noticed unfavourable, but seamless transitions were obtained by deploying a soft cold load pickup and voltage synchronization process.

Secondary ozone peaks in the troposphere over the Himalayas

Directory of Open Access Journals (Sweden)

N. Ojha

2017-06-01

Full Text Available Layers with strongly enhanced ozone concentrations in the middle–upper troposphere, referred to as secondary ozone peaks (SOPs, have been observed in different regions of the world. Here we use the global ECHAM5/MESSy atmospheric chemistry model (EMAC to (i investigate the processes causing SOPs, (ii explore both their frequency of occurrence and seasonality, and (iii assess their effects on the tropospheric ozone budget over the Himalayas. The vertical profiles of potential vorticity (PV and a stratospheric ozone tracer (O3s in EMAC simulations, in conjunction with the structure of SOPs, suggest that SOPs over the Himalayas are formed by stratosphere-to-troposphere transport (STT of ozone. The spatial distribution of O3s further shows that such effects are in general most pronounced in the northern part of India. Model simulated ozone distributions and backward air trajectories show that ozone rich air masses, associated with STT, originate as far as northern Africa and the North Atlantic Ocean, the Middle East, as well as in nearby regions in Afghanistan and Pakistan, and are rapidly (within 2–3 days transported to the Himalayas. Analysis of a 15-year (2000–2014 EMAC simulation shows that the frequency of SOPs is highest during the pre-monsoon season (e.g. 11 % of the time in May, while no intense SOP events are found during the July–October period. The SOPs are estimated to enhance the tropospheric column ozone (TCO over the central Himalayas by up to 21 %.

Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

Science.gov (United States)

2013-01-01

Background Qualitative research methods are increasingly used within clinical trials to address broader research questions than can be addressed by quantitative methods alone. These methods enable health professionals, service users, and other stakeholders to contribute their views and experiences to evaluation of healthcare treatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information that is better able to reform policy or influence design. Methods Health services researchers, including trialists, clinicians, and qualitative researchers, worked collaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales Organisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has recently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a total of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP). Results The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative components of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative researchers should be contributors from the start of trials with qualitative potential; the qualitative component should have clear aims; and the main study publication should report on the qualitative component. Conclusions We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative trials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and contributes to the future development of multi-method trials. PMID:23433341

Core-shell microparticles for protein sequestration and controlled release of a protein-laden core.

Science.gov (United States)

Rinker, Torri E; Philbrick, Brandon D; Temenoff, Johnna S

2017-07-01

Development of multifunctional biomaterials that sequester, isolate, and redeliver cell-secreted proteins at a specific timepoint may be required to achieve the level of temporal control needed to more fully regulate tissue regeneration and repair. In response, we fabricated core-shell heparin-poly(ethylene-glycol) (PEG) microparticles (MPs) with a degradable PEG-based shell that can temporally control delivery of protein-laden heparin MPs. Core-shell MPs were fabricated via a re-emulsification technique and the number of heparin MPs per PEG-based shell could be tuned by varying the mass of heparin MPs in the precursor PEG phase. When heparin MPs were loaded with bone morphogenetic protein-2 (BMP-2) and then encapsulated into core-shell MPs, degradable core-shell MPs initiated similar C2C12 cell alkaline phosphatase (ALP) activity as the soluble control, while non-degradable core-shell MPs initiated a significantly lower response (85+19% vs. 9.0+4.8% of the soluble control, respectively). Similarly, when degradable core-shell MPs were formed and then loaded with BMP-2, they induced a ∼7-fold higher C2C12 ALP activity than the soluble control. As C2C12 ALP activity was enhanced by BMP-2, these studies indicated that degradable core-shell MPs were able to deliver a bioactive, BMP-2-laden heparin MP core. Overall, these dynamic core-shell MPs have the potential to sequester, isolate, and then redeliver proteins attached to a heparin core to initiate a cell response, which could be of great benefit to tissue regeneration applications requiring tight temporal control over protein presentation. Tissue repair requires temporally controlled presentation of potent proteins. Recently, biomaterial-mediated binding (sequestration) of cell-secreted proteins has emerged as a strategy to harness the regenerative potential of naturally produced proteins, but this strategy currently only allows immediate amplification and re-delivery of these signals. The multifunctional, dynamic

PWR degraded core analysis

International Nuclear Information System (INIS)

Gittus, J.H.

1982-04-01

A review is presented of the various phenomena involved in degraded core accidents and the ensuing transport of fission products from the fuel to the primary circuit and the containment. The dominant accident sequences found in the PWR risk studies published to date are briefly described. Then chapters deal with the following topics: the condition and behaviour of water reactor fuel during normal operation and at the commencement of degraded core accidents; the generation of hydrogen from the Zircaloy-steam and the steel-steam reactions; the way in which the core deforms and finally melts following loss of coolant; debris relocation analysis; containment integrity; fission product behaviour during a degraded core accident. (U.K.)

Single photon core ionization with core excitation: a new spectroscopic tool

International Nuclear Information System (INIS)

Penent, F; Carniato, S; Lablanquie, P; Selles, P; Palaudoux, J; Andric, L; Žitnik, M; Bučar, K; Shigemasa, E; Nakano, M; Ito, K; Hikosaka, Y

2015-01-01

The simultaneous core ionization and core excitation process (or K -2 V process) induced by absorption of a single photon provides the basis of a new spectroscopy that offers both advantages of X-ray Photoelectron Spectroscopy (XPS) and near-edge x-ray absorption fine structures (NEXAFS) spectroscopy (paper)

Evaluation of core distortion in FBR

International Nuclear Information System (INIS)

Ikarimoto, I.; Tanaka, M.; Okubo, Y.

1984-01-01

The analyses of FBR's core distortion are mainly performed in order to evaluate the following items: 1) Change of reactivity; 2) Force at pads on core assemblies; 3) Withdrawal force at refueling; 4) Loading, refueling and residual deviations of wrapper tubes (core assemblies) at the top; 5) Bowing modes of guide tubes for control rods. The analysis of core distortion are performed by using computer program for two-dimensional row deformation analysis or three-dimensional core deformation if necessary, considering these evaluated items which become design conditions. This report shows the relationship between core deformation analysis and component design, a point of view of choosing an analysis program for design considering core characteristics, and computing examples of core deformation of prototype class reactor by the above code. (author)

Termination of light-water reactor core-melt accidents with a chemical core catcher: the core-melt source reduction system (COMSORS)

International Nuclear Information System (INIS)

Forsberg, C.W.; Parker, G.W.; Rudolph, J.C.; Osborne-Lee, I.W.; Kenton, M.A.

1996-09-01

The Core-Melt Source Reduction System (COMSORS) is a new approach to terminate light-water reactor core melt accidents and ensure containment integrity. A special dissolution glass is placed under the reactor vessel. If core debris is released onto the glass, the glass melts and the debris dissolves into the molten glass, thus creating a homogeneous molten glass. The molten glass, with dissolved core debris, spreads into a wide pool, distributing the heat for removal by radiation to the reactor cavity above or by transfer to water on top of the molten glass. Expected equilibrium glass temperatures are approximately 600 degrees C. The creation of a low-temperature, homogeneous molten glass with known geometry permits cooling of the glass without threatening containment integrity. This report describes the technology, initial experiments to measure key glass properties, and modeling of COMSORS operations

Reactor core in FBR type reactor

International Nuclear Information System (INIS)

Masumi, Ryoji; Kawashima, Katsuyuki; Kurihara, Kunitoshi.

1989-01-01

In a reactor core in FBR type reactors, a portion of homogenous fuels constituting the homogenous reactor core is replaced with multi-region fuels in which the enrichment degree of fissile materials is lower nearer to the axial center. This enables to condition the composition such that a reactor core having neutron flux distribution either of a homogenous reactor core or a heterogenous reactor core has substantially identical reactivity. Accordingly, in the transfer from the homogenous reactor core to the axially heterogenous reactor core, the average reactivity in the reactor core is substantially equal in each of the cycles. Further, by replacing a portion of the homogenous fuels with a multi-region fuels, thereby increasing the heat generation near the axial center, it is possiable to reduce the linear power output in the regions above and below thereof and, in addition, to improve the thermal margin in the reactor core. (T.M.)

JOYO MK-II core characteristics database

International Nuclear Information System (INIS)

Tabuchi, Shiro; Aoyama, Takafumi; Nagasaki, Hideaki; Kato, Yuichi

1998-12-01

The experimental fast reactor JOYO served as the MK-II irradiation bed core for testing fuel and material for FBR development for 15 years from 1982 to 1997. During the MK-II operation, extensive data were accumulated from the core characteristics tests conducted in thirty-one duty operations and thirteen special test operations. These core management data and core characteristics data were compiled into a database. The code system MAGI has been developed and used for core management of JOYO MK-II, and the core characteristics and the irradiation test conditions were calculated using MAGI on the basis of three dimensional diffusion theory with seven neutron energy groups. The core management data include extensive data, which were recorded on CD-ROM for user convenience. The data are specifications and configurations of the core, and for about 300 driver fuel subassemblies and about 60 uninstrumented irradiation subassemblies are core composition before and after irradiation, neutron flux, neutron fluences, fuel and control rod burn-up, and temperature and power distributions. MK-II core characteristics and test conditions were stored in the database for post analysis. Core characteristics data include excess reactivities, control rod worths, and reactivity coefficients, e.g., temperature, power and burn-up. Test conditions include both measured and calculated data for irradiation conditions. (author)

AGR core safety assessment methodologies

International Nuclear Information System (INIS)

McLachlan, N.; Reed, J.; Metcalfe, M.P.

1996-01-01

To demonstrate the safety of its gas-cooled graphite-moderated AGR reactors, nuclear safety assessments of the cores are based upon a methodology which demonstrates no component failures, geometrical stability of the structure and material properties bounded by a database. All AGRs continue to meet these three criteria. However, predictions of future core behaviour indicate that the safety case methodology will eventually need to be modified to deal with new phenomena. A new approach to the safety assessment of the cores is currently under development, which can take account of these factors while at the same time providing the same level of protection for the cores. This approach will be based on the functionality of the core: unhindered movement of control rods, continued adequate cooling of the fuel and the core, continued ability to charge and discharge fuel. (author). 5 figs

Monitoring an electric cable core

International Nuclear Information System (INIS)

Bhattacharya, S.; Marris, A.

1984-01-01

A method of, and apparatus for, continuously monitoring an advancing core having a continuous covering comprises directing X-ray radiation laterally towards the advancing covered core; continuously forming an X-ray image pattern of the advancing covered core and translating the image pattern into a visible image pattern; continuously transforming the visible pattern into a digital bit pattern; and processing the digital bit pattern using a microprocessor with interfacing electronics to provide an image profile of the advancing covered core and/or to provide analogue and/or digital signals indicative of the overall diameter and eccentricity of the covered core and of the thickness of the covering. (author)

Core-annular flow through a horizontal pipe : Hydrodynamic counterbalancing of buoyancy force on core

NARCIS (Netherlands)

Ooms, G.; Vuik, C.; Poesio, P.

2007-01-01

A theoretical investigation has been made of core-annular flow: the flow of a high-viscosity liquid core surrounded by a low-viscosity liquid annular layer through a horizontal pipe. Special attention is paid to the question of how the buoyancy force on the core, caused by a density difference

Construction and utilization of linear empirical core models for PWR in-core fuel management

International Nuclear Information System (INIS)

Okafor, K.C.

1988-01-01

An empirical core-model construction procedure for pressurized water reactor (PWR) in-core fuel management is developed that allows determining the optimal BOC k ∞ profiles in PWRs as a single linear-programming problem and thus facilitates the overall optimization process for in-core fuel management due to algorithmic simplification and reduction in computation time. The optimal profile is defined as one that maximizes cycle burnup. The model construction scheme treats the fuel-assembly power fractions, burnup, and leakage as state variables and BOC zone enrichments as control variables. The core model consists of linear correlations between the state and control variables that describe fuel-assembly behavior in time and space. These correlations are obtained through time-dependent two-dimensional core simulations. The core model incorporates the effects of composition changes in all the enrichment control zones on a given fuel assembly and is valid at all times during the cycle for a given range of control variables. No assumption is made on the geometry of the control zones. A scatter-composition distribution, as well as annular, can be considered for model construction. The application of the methodology to a typical PWR core indicates good agreement between the model and exact simulation results

A volatile-rich Earth's core inferred from melting temperature of core materials

Science.gov (United States)

Morard, G.; Andrault, D.; Antonangeli, D.; Nakajima, Y.; Auzende, A. L.; Boulard, E.; Clark, A. N.; Lord, O. T.; Cervera, S.; Siebert, J.; Garbarino, G.; Svitlyk, V.; Mezouar, M.

2016-12-01

Planetary cores are mainly constituted of iron and nickel, alloyed with lighter elements (Si, O, C, S or H). Understanding how these elements affect the physical and chemical properties of solid and liquid iron provides stringent constraints on the composition of the Earth's core. In particular, melting curves of iron alloys are key parameter to establish the temperature profile in the Earth's core, and to asses the potential occurrence of partial melting at the Core-Mantle Boundary. Core formation models based on metal-silicate equilibration suggest that Si and O are the major light element components1-4, while the abundance of other elements such as S, C and H is constrained by arguments based on their volatility during planetary accretion5,6. Each compositional model implies a specific thermal state for the core, due to the different effect that light elements have on the melting behaviour of Fe. We recently measured melting temperatures in Fe-C and Fe-O systems at high pressures, which complete the data sets available both for pure Fe7 and other binary alloys8. Compositional models with an O- and Si-rich outer core are suggested to be compatible with seismological constraints on density and sound velocity9. However, their crystallization temperatures of 3650-4050 K at the CMB pressure of 136 GPa are very close to, if not higher than the melting temperature of the silicate mantle and yet mantle melting above the CMB is not a ubiquitous feature. This observation requires significant amounts of volatile elements (S, C or H) in the outer core to further reduce the crystallisation temperature of the core alloy below that of the lower mantle. References 1. Wood, B. J., et al Nature 441, 825-833 (2006). 2. Siebert, J., et al Science 339, 1194-7 (2013). 3. Corgne, A., et al Earth Planet. Sc. Lett. 288, 108-114 (2009). 4. Fischer, R. a. et al. Geochim. Cosmochim. Acta 167, 177-194 (2015). 5. Dreibus, G. & Palme, H. Geochim. Cosmochim. Acta 60, 1125-1130 (1995). 6. Mc

Precise seismic-wave velocity atop Earth's core: No evidence for outer-core stratification

Science.gov (United States)

Alexandrakis, Catherine; Eaton, David W.

2010-05-01

Earth's outer core is composed of liquid Fe and Ni alloyed with a ˜10% fraction of light elements such as O, S, or Si. Secular cooling and compositional buoyancy drive vigorous convection that sustains the geodynamo, but critical details of light-element composition and thermal regime remain uncertain. Seismic velocities can provide important observational constraints on these parameters, but global reference models such as Preliminary Reference Earth Model ( PREM), IASP91 and AK135 exhibit significant discrepancies in the outermost ˜200 km of the core. Here, we apply an Empirical Transfer Function method to obtain precise arrival times for SmKS waves, a whispering-gallery mode that propagates near the underside of the core-mantle boundary. Models that fit our data are all characterized by seismic velocities and depth gradients in the outermost 200 km of the core that correspond best with PREM. This similarity to PREM, which has a smooth velocity profile that satisfies the adiabatic Adams and Williamson equation, argues against the presence of an anomalous layer of light material near the top of the core as suggested in some previous studies. A new model, AE09, is proposed as a slight modification to PREM for use as a reference model of the outermost core.

Method for orienting a borehole core

International Nuclear Information System (INIS)

Henry, W.

1980-01-01

A method is described for longitudinally orienting a borehold core with respect to the longitudinal axis of the drill string which drilled said borehold core in such a manner that the original longitudinal attitude of said borehold core within the earth may be determined. At least a portion of said borehold core is partialy demagnetized in steps to thereby at least partially remove in steps the artificial remanent magnetism imparted to said borehole core by said drill string. The artifical remanent magnetism is oriented substantially parallel to the longitudinal axis of said drill string. The direction and intensity of the total magnetism of said borehold core is measured at desired intervals during the partial demagnetizing procedure. An artificial remanent magnetism vector is established which extends from the final measurement of the direction and intensity of the total magnetism of said borehole core taken during said partial demagnetizing procedure towards the initial measurement of the direction and intensity of the total magnetism of said borehold core taken during said partial demagnetizing procedure. The borehold core is oriented in such a manner that said artificial remanent magnetism vector points at least substantially downwardly towards the bottom of said borehold core for a borehold in the northern hemisphere and points at least substantailly upwardly towards the top of said borehole core for a borehole in the southern hemisphere

Heterogeneous gas core reactor

International Nuclear Information System (INIS)

Diaz, N.J.; Dugan, E.T.

1983-01-01

A heterogeneous gas core nuclear reactor is disclosed comprising a core barrel provided interiorly with an array of moderator-containing tubes and being otherwise filled with a fissile and/or fertile gaseous fuel medium. The fuel medium may be flowed through the chamber and through an external circuit in which heat is extracted. The moderator may be a fluid which is flowed through the tubes and through an external circuit in which heat is extracted. The moderator may be a solid which may be cooled by a fluid flowing within the tubes and through an external heat extraction circuit. The core barrel is surrounded by moderator/coolant material. Fissionable blanket material may be disposed inwardly or outwardly of the core barrel

In-core monitoring detectors

International Nuclear Information System (INIS)

Mitelman, M.G.

2001-01-01

The main task of in-core monitoring consists in securing observability of the reactor installation in all possible operation modes (normal, transient, accident and post-accident). Operation safety at acceptable cost can be achieved by optimized measurement errors. The range of sensors applied as in-core detectors for operative measurements in the industry is very limited in number. Among them might be cited self powered neutron detectors (SPND) and thermocouples. Sensors are incorporated in the in-core detectors assemblies (SVRD). The presentation makes an effort to touch upon the problems of assuring and increasing quality of in-core on-line measurements. So we do not consider systems using movable detectors, as the latter do not assure on-line measurements. (Authors)

Core principles of evolutionary medicine

Science.gov (United States)

Grunspan, Daniel Z; Nesse, Randolph M; Barnes, M Elizabeth; Brownell, Sara E

2018-01-01

Abstract Background and objectives Evolutionary medicine is a rapidly growing field that uses the principles of evolutionary biology to better understand, prevent and treat disease, and that uses studies of disease to advance basic knowledge in evolutionary biology. Over-arching principles of evolutionary medicine have been described in publications, but our study is the first to systematically elicit core principles from a diverse panel of experts in evolutionary medicine. These principles should be useful to advance recent recommendations made by The Association of American Medical Colleges and the Howard Hughes Medical Institute to make evolutionary thinking a core competency for pre-medical education. Methodology The Delphi method was used to elicit and validate a list of core principles for evolutionary medicine. The study included four surveys administered in sequence to 56 expert panelists. The initial open-ended survey created a list of possible core principles; the three subsequent surveys winnowed the list and assessed the accuracy and importance of each principle. Results Fourteen core principles elicited at least 80% of the panelists to agree or strongly agree that they were important core principles for evolutionary medicine. These principles over-lapped with concepts discussed in other articles discussing key concepts in evolutionary medicine. Conclusions and implications This set of core principles will be helpful for researchers and instructors in evolutionary medicine. We recommend that evolutionary medicine instructors use the list of core principles to construct learning goals. Evolutionary medicine is a young field, so this list of core principles will likely change as the field develops further. PMID:29493660

Early Dynamics of the Moon's Core

Science.gov (United States)

Cuk, Matija; Hamilton, Douglas; Stewart, Sarah T.

2018-04-01

The Moon has a small molten iron core (Williams et al. 2006). Remanent magnetization in lunar rocks likely derives from a past lunar dynamo (Wieczorek 2018 and references therein), which may have been powered by differential precession between the mantle and the core. The rotations of the lunar mantle and core were largely decoupled for much of lunar history, with a large mutual offset during the Cassini State Transition (Meyer and Wisdom, 2011). It is likely that the past work underestimated lunar obliquities, and therefore core offsets, during early lunar history (Cuk et al. 2016). Here we investigate the dynamics of the lunar core and mantle using a Lie-Poisson numerical integrator (Touma and Wisdom 2001) which includes interactions between triaxial core and mantle, as well as all gravitational and tidal effects included in the model of Cuk et al. (2016). Since we assume a rigid triaxial mantle, this model is applicable to the Moon only once it has acquired its current shape, which probably happened before the Moon reached 25 Earth radii. While some details of the core dynamics depend on our assumptions about the shape of the lunar core-mantle boundary, we can report some robust preliminary findings. The presence of the core does not change significantly the evolutionary scenario of Cuk et al. (2016). The core and mantle are indeed decoupled, with the core having a much smaller obliquity to the ecliptic than the mantle for almost all of the lunar history. The core was largely in an equivalent of Cassini State 2, with the vernal equinoxes (wrt the ecliptic) of the core and the mantle being anti-aligned. The core-mantle spin axis offset has been very large during the Moon's first billion years (this is true both in canonical and high-inclination tidal evolution), causing the lunar core to be sub-synchronous. If the ancient lunar magnetic dipole was rotating around the core axis that was inclined to the Moon's spin axis, then the magnetic poles would move across

Reactor core of FBR type reactor

International Nuclear Information System (INIS)

Hayashi, Hideyuki; Ichimiya, Masakazu.

1994-01-01

A reactor core is a homogeneous reactor core divided into two regions of an inner reactor core region at the center and an outer reactor core region surrounding the outside of the inner reactor core region. In this case, the inner reactor core region has a lower plutonium enrichment degree and less amount of neutron leakage in the radial direction, and the outer reactor core region has higher plutonium enrichment degree and greater amount of neutron leakage in the radial direction. Moderator materials containing hydrogen are added only to the inner reactor core fuels in the inner reactor core region. Pins loaded with the fuels with addition of the moderator materials are inserted at a ratio of from 3 to 10% of the total number of the fuel pins. The moderator materials containing hydrogen comprise zirconium hydride, titanium hydride, or calcium hydride. With such a constitution, fluctuation of the power distribution in the radial direction along with burning is suppressed. In addition, an absolute value of the Doppler coefficient can be increased, and a temperature coefficient of coolants can be reduced. (I.N.)

New product introduction and supplier integration in sales and operations planning : evidence from the Asia Pacific region

OpenAIRE

Goh, Shao Hung; Eldridge, Stephen

2015-01-01

Purpose: This paper investigates the implementation and performance benefits of Sales and Operations Planning (S&OP) within organizations in Asia Pacific. Design/methodology/approach: A case study method was used, with two companies selected. The first company had recently commenced S&OP and applied it to facilitate New Product Introduction, while the second had integrated its supplier into an existing S&OP program. Supply chain performance data was collected and analyzed in the context of an...

Reactor core control device

International Nuclear Information System (INIS)

Sano, Hiroki

1998-01-01

The present invention provides a reactor core control device, in which switching from a manual operation to an automatic operation, and the control for the parameter of an automatic operation device are facilitated. Namely, the hysteresis of the control for the operation parameter by an manual operation input means is stored. The hysteresis of the control for the operation parameter is collected. The state of the reactor core simulated by an operation control to which the collected operation parameters are manually inputted is determined as an input of the reactor core state to the automatic input means. The record of operation upon manual operation is stored as a hysteresis of control for the operation parameter, but the hysteresis information is not only the result of manual operation of the operation parameter. This is results of operation conducted by a skilled operator who judge the state of the reactor core to be optimum. Accordingly, it involves information relevant to the reactor core state. Then, it is considered that the optimum automatic operation is not deviated greatly from the manual operation. (I.S.)

Challenges for proteomics core facilities.

Science.gov (United States)

Lilley, Kathryn S; Deery, Michael J; Gatto, Laurent

2011-03-01

Many analytical techniques have been executed by core facilities established within academic, pharmaceutical and other industrial institutions. The centralization of such facilities ensures a level of expertise and hardware which often cannot be supported by individual laboratories. The establishment of a core facility thus makes the technology available for multiple researchers in the same institution. Often, the services within the core facility are also opened out to researchers from other institutions, frequently with a fee being levied for the service provided. In the 1990s, with the onset of the age of genomics, there was an abundance of DNA analysis facilities, many of which have since disappeared from institutions and are now available through commercial sources. Ten years on, as proteomics was beginning to be utilized by many researchers, this technology found itself an ideal candidate for being placed within a core facility. We discuss what in our view are the daily challenges of proteomics core facilities. We also examine the potential unmet needs of the proteomics core facility that may also be applicable to proteomics laboratories which do not function as core facilities. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Separated core turbofan engine; Core bunrigata turbofan engine

Energy Technology Data Exchange (ETDEWEB)

Saito, Y; Endo, M; Matsuda, Y; Sugiyama, N; Sugahara, N; Yamamoto, K [National Aerospace Laboratory, Tokyo (Japan)

1996-04-01

This report outlines the separated core turbofan engine. This engine is featured by parallel separated arrangement of a fan and core engine which are integrated into one unit in the conventional turbofan engine. In general, cruising efficiency improvement and noise reduction are achieved by low fan pressure ratio and low exhaust speed due to high bypass ratio, however, it causes various problems such as large fan and nacelle weight due to large air flow rate of a fan, and shift of an operating point affected by flight speed. The parallel separated arrangement is thus adopted. The stable operation of a fan and core engine is easily retained by independently operating air inlet unaffected by fan. The large degree of freedom of combustion control is also obtained by independent combustor. Fast response, simple structure and optimum aerodynamic design are easily achieved. This arrangement is also featured by flexibility of development and easy maintenance, and by various merits superior to conventional turbofan engines. It has no technological problems difficult to be overcome, and is also suitable for high-speed VTOL transport aircraft. 4 refs., 5 figs.

The earths innermost core

International Nuclear Information System (INIS)

Nanda, J.N.

1989-01-01

A new earth model is advanced with a solid innermost core at the centre of the Earth where elements heavier than iron, over and above what can be retained in solution in the iron core, are collected. The innermost core is separated from the solid iron-nickel core by a shell of liquid copper. The innermost core has a natural vibration measured on the earth's surface as the long period 26 seconds microseisms. The earth was formed initially as a liquid sphere with a relatively thin solid crust above the Byerly discontinuity. The trace elements that entered the innermost core amounted to only 0.925 ppm of the molten mass. Gravitational differentiation must have led to the separation of an explosive thickness of pure 235 U causing a fission explosion that could expel beyond the Roche limit a crustal scab which would form the centre piece of the moon. A reservoir of helium floats on the liquid copper. A small proportion of helium-3, a relic of the ancient fission explosion present there will spell the exciting magnetic field. The field is stable for thousands of years because of the presence of large quantity of helium-4 which accounts for most of the gaseous collisions that will not disturb the atomic spin of helium-3 atoms. This field is prone to sudden reversals after long periods of stability. (author). 14 refs

Peripheral blood antigen presenting cell responses in otitis-prone and non-otitis-prone infants.

Science.gov (United States)

Surendran, Naveen; Nicolosi, Ted; Kaur, Ravinder; Pichichero, Michael E

2016-01-01

Stringently defined otitis-prone (sOP) children represent a new classification of the otitis-prone condition. Previous studies showed dysfunction in Ab, B-cell memory and T-cell memory responses. We sought to determine whether there are defects in numbers, phenotype and/or function of professional APC in the peripheral blood of sOP infants. APC phenotypic counts, MHC II expression and intracellular cytokine levels were determined in response to TLR7/8 (R848) stimulation by flow cytometry. Innate immune mRNA expression was measured using RT-PCR and cytokines were measured using Luminex technology. Significant (P otitis-prone (NOP) age-matched infants. No significant differences in APC activation or function were observed. Expression of various TLRs, intracellular signaling molecules and downstream cytokines was also not found to be significantly different between sOP and NOP infants. Higher numbers of APCs in sOP infants suggest the possibility of a persistent mucosal inflammatory status. Transcriptional and cytokine profiles of PBMCs among sOP infants suggest their systemic innate responses are not different compared to NOP infants. © The Author(s) 2015.

LMFBR Ultra Long Life Cores

International Nuclear Information System (INIS)

Schmidt, J.E.; Doncals, R.A.; Porter, C.A.; Gundy, L.M.

1986-01-01

The Ultra Long Life Core is an attractive and innovative design approach with several extremely beneficial attributes. Long Life cores are applicable to the full range of LMR plant sizes resulting in lifetimes up to 30 years. Core life is somewhat limited for smaller plant sizes, however significant benefits of this approach still exist for all plant sizes. The union of long life cores and the complementary inherent safety technology offer a means of utilizing the well-proven oxide fuel in a system with unsurpassed safety capability. A further benefit is that the uranium fuel cycle can be used in long life cores, especially for initial LMR plant deployment, thereby eliminating the need for reprocessing prior to starting LMR plant construction in the U.S. Finally the long life core significantly reduces power costs. With inherent safety capability designed into an LMR and with the ULLC fuel cycle, power costs competitive with light water plants are achievable while offering improved operational flexibility derived through extending refueling intervals

Ultrabroadband polarization splitter based on three-core photonic crystal fiber with a modulation core.

Science.gov (United States)

Zhao, Tongtong; Lou, Shuqin; Wang, Xin; Zhou, Min; Lian, Zhenggang

2016-08-10

We design an ultrabroadband polarization splitter based on three-core photonic crystal fiber (PCF). A modulation core and two fluorine-doped cores are introduced to achieve an ultrawide bandwidth. The properties of three-core PCF are modeled by using the full-vector finite element method along with the full-vector beam propagation method. Numerical results demonstrate that an ultrabroadband splitter with 320 nm bandwidth with an extinction ratio as low as -20  dB can be achieved by using 52.8 mm long three-core PCF. This splitter also has high compatibility with standard single-mode fibers as the input and output ports due to low splicing loss of 0.02 dB. All the air holes in the proposed structure are circular holes and arranged in a triangular lattice that makes it easy to fabricate.

Proposal of a benchmark for core burnup calculations for a VVER-1000 reactor core

International Nuclear Information System (INIS)

Loetsch, T.; Khalimonchuk, V.; Kuchin, A.

2009-01-01

In the framework of a project supported by the German BMU the code DYN3D should be further validated and verified. During the work a lack of a benchmark on core burnup calculations for VVER-1000 reactors was noticed. Such a benchmark is useful for validating and verifying the whole package of codes and data libraries for reactor physics calculations including fuel assembly modelling, fuel assembly data preparation, few group data parametrisation and reactor core modelling. The benchmark proposed specifies the core loading patterns of burnup cycles for a VVER-1000 reactor core as well as a set of operational data such as load follow, boron concentration in the coolant, cycle length, measured reactivity coefficients and power density distributions. The reactor core characteristics chosen for comparison and the first results obtained during the work with the reactor physics code DYN3D are presented. This work presents the continuation of efforts of the projects mentioned to estimate the accuracy of calculated characteristics of VVER-1000 reactor cores. In addition, the codes used for reactor physics calculations of safety related reactor core characteristics should be validated and verified for the cases in which they are to be used. This is significant for safety related evaluations and assessments carried out in the framework of licensing and supervision procedures in the field of reactor physics. (authors)

Reactor core and initially loaded reactor core of nuclear reactor

International Nuclear Information System (INIS)

Koyama, Jun-ichi; Aoyama, Motoo.

1989-01-01

In BWR type reactors, improvement for the reactor shutdown margin is an important characteristic condition togehter with power distribution flattening . However, in the reactor core at high burnup degree, the reactor shutdown margin is different depending on the radial position of the reactor core. That is , the reactor shutdown margin is smaller in the outer peripheral region than in the central region of the reactor core. In view of the above, the reactor core is divided radially into a central region and as outer region. The amount of fissionable material of first fuel assemblies newly loaded in the outer region is made less than the amount of the fissionable material of second fuel assemblies newly loaded in the central region, to thereby improve the reactor shutdown margin in the outer region. Further, the ratio between the amount of the fissionable material in the upper region and that of the fissionable material in the lower portion of the first fuel assemblies is made smaller than the ratio between the amount of the fissionable material in the upper region and that of the fissionable material in the lower region of the second fuel assemblies, to thereby obtain a sufficient thermal margin in the central region. (K.M.)

High-resolution gamma ray attenuation density measurements on mining exploration drill cores, including cut cores

Science.gov (United States)

Ross, P.-S.; Bourke, A.

2017-01-01

Physical property measurements are increasingly important in mining exploration. For density determinations on rocks, one method applicable on exploration drill cores relies on gamma ray attenuation. This non-destructive method is ideal because each measurement takes only 10 s, making it suitable for high-resolution logging. However calibration has been problematic. In this paper we present new empirical, site-specific correction equations for whole NQ and BQ cores. The corrections force back the gamma densities to the "true" values established by the immersion method. For the NQ core caliber, the density range extends to high values (massive pyrite, 5 g/cm3) and the correction is thought to be very robust. We also present additional empirical correction factors for cut cores which take into account the missing material. These "cut core correction factors", which are not site-specific, were established by making gamma density measurements on truncated aluminum cylinders of various residual thicknesses. Finally we show two examples of application for the Abitibi Greenstone Belt in Canada. The gamma ray attenuation measurement system is part of a multi-sensor core logger which also determines magnetic susceptibility, geochemistry and mineralogy on rock cores, and performs line-scan imaging.

Superrotation of Earth’s Inner Core, Extraterrestrial Impacts, and the Effective Viscosity of Outer Core

OpenAIRE

Pirooz Mohazzabi; John D. Skalbeck

2015-01-01

The recently verified superrotation of Earth’s inner core is examined and a new model is presented which is based on the tidal despinning of the mantle and the viscosity of the outer core. The model also takes into account other damping mechanisms arising from the inner core superrotation such as magnetic and gravitational coupling as well as contribution from eddy viscosity in the outer core. The effective viscosity obtained in this model confirms a previously well constrained value of about...

Core body temperature in obesity123

Science.gov (United States)

Heikens, Marc J; Gorbach, Alexander M; Eden, Henry S; Savastano, David M; Chen, Kong Y; Skarulis, Monica C

2011-01-01

Background: A lower core body temperature set point has been suggested to be a factor that could potentially predispose humans to develop obesity. Objective: We tested the hypothesis that obese individuals have lower core temperatures than those in normal-weight individuals. Design: In study 1, nonobese [body mass index (BMI; in kg/m2) <30] and obese (BMI ≥30) adults swallowed wireless core temperature–sensing capsules, and we measured core temperatures continuously for 24 h. In study 2, normal-weight (BMI of 18–25) and obese subjects swallowed temperature-sensing capsules to measure core temperatures continuously for ≥48 h and kept activity logs. We constructed daily, 24-h core temperature profiles for analysis. Results: Mean (±SE) daily core body temperature did not differ significantly between the 35 nonobese and 46 obese subjects (36.92 ± 0.03°C compared with 36.89 ± 0.03°C; P = 0.44). Core temperature 24-h profiles did not differ significantly between 11 normal-weight and 19 obese subjects (P = 0.274). Women had a mean core body temperature ≈0.23°C greater than that of men (36.99 ± 0.03°C compared with 36.76 ± 0.03°C; P < 0.0001). Conclusions: Obesity is not generally associated with a reduced core body temperature. It may be necessary to study individuals with function-altering mutations in core temperature–regulating genes to determine whether differences in the core body temperature set point affect the regulation of human body weight. These trials were registered at clinicaltrials.gov as NCT00428987 and NCT00266500. PMID:21367952

Nuclear reactor core catcher

International Nuclear Information System (INIS)

1977-01-01

A nuclear reactor core catcher is described for containing debris resulting from an accident causing core meltdown and which incorporates a method of cooling the debris by the circulation of a liquid coolant. (U.K.)

Digital data storage of core image using high resolution full color core scanner; Kokaizodo full color scanner wo mochiita core image no digital ka

Energy Technology Data Exchange (ETDEWEB)

Takahashi, W; Ujo, S; Osato, K; Takasugi, S [Geothermal Energy Research and Development Co. Ltd., Tokyo (Japan)

1996-05-01

This paper reports on digitization of core images by using a new type core scanner system. This system consists of a core scanner unit (equipped with a CCD camera), a personal computer and ancillary devices. This is a modification of the old type system, with measurable core length made to 100 cm/3 scans, and resolution enhanced to 5100 pixels/m (1024 pixels/m in the old type). The camera was changed to that of a color specification, and the A/D conversion was improved to 24-bit full color. As a result of carrying out a detail reproduction test on digital images of this core scanner, it was found that objects can be identified at a level of about the size of pixels constituting the image in the case when the best contrast is obtained between the objects and the background, and that in an evaluation test on visibility of concaves and convexes on core surface, reproducibility is not very good in large concaves and convexes. 2 refs., 6 figs.

77 FR 30435 - In-core Thermocouples at Different Elevations and Radial Positions in Reactor Core

Science.gov (United States)

2012-05-23

... NUCLEAR REGULATORY COMMISSION 10 CFR Part 50 [Docket No. PRM-50-105; NRC-2012-0056] In-core Thermocouples at Different Elevations and Radial Positions in Reactor Core AGENCY: Nuclear Regulatory Commission... of operating licenses for nuclear power plants (``NPP'') to operate NPPs with in-core thermocouples...

A benefit assessment of using in-core neutron detector signals in core protection calculator system (CPCS)

International Nuclear Information System (INIS)

Han, S.; Park, S.J.; Seong, P.H.

1997-01-01

A Core Protection Calculator System (CPCS) is a digital computer based safety system generating trip signals based on the calculation of Departure from Nucleate Boiling Ratio (DNBR) and Local Power Density (LPD). Currently, CPCS uses ex-core detector signals for core power calculation and it has some uncertainties. In this study, in-core detector signals which directly measure inside flux of core are applied to CPCS to get more accurate power distribution profile, DNBR and LPD. In order to improve axial power distribution calculation, piece-wise cubic Spline method is applied; from the 40 nodes of expanded signals, more accurate and detailed core information can be provided. Simulation is carried out to verify its applicability to power distribution calculation. Simulation result shows that the improved method reduces the calculational uncertainties significantly and it allows larger operational margin. It is also expected that no power reduction is required while Core Operating Limit Supervisory System (COLSS) is out-of-service due to reduced uncertainties when the improved method is applied. In this study, a quantitative economic benefit assessment of using in-core neutron detector signals is also carried out. (authors)

A benefit assessment of using in-core neutron detector signals in core protection calculator system(CPCS)

International Nuclear Information System (INIS)

Han, Seung

1996-02-01

A Core Protection Calculator System(CPCS) is a digital computer based safety system generating trip signals based on the calculation of Departure from Nucleate Boiling Ratio(DNBR) and Local Power Density(LPD). Currently, CPCS uses ex-core detector signals for core power calculation and it has some uncertainties. In this study, In-core detector signals which directly measure inside flux of core are applied to CPCS to get more accurate power distribution profile, DNBR and LPD. In order to improve axial power distribution calculation, piecewise cubic spline method is applied: From the 40 nodes of expanded signals, more accurate and detailed core information can be provided. Simulation is carried out to verify its applicability to power distribution calculation. Simulation result shows that the improved method reduces the calculational uncertainties significantly and it allows larger operational margin. It is also expected that no power reduction is required while Core Operating Limit Supervisory System(COLSS) is out-of-service due to reduced uncertainties when the improved method is applied. In this study, a quantitative economic benefit assessment of using in-core neutron detector signals is also carried out

Evaluating Community Health Advisor (CHA) Core Competencies: The CHA Core Competency Retrospective Pretest/Posttest (CCCRP).

Science.gov (United States)

Story, Lachel; To, Yen M

2016-05-01

Health care and academic systems are increasingly collaborating with community health advisors (CHAs) to provide culturally relevant health interventions that promote sustained community transformation. Little attention has been placed on CHA training evaluation, including core competency attainment. This study identified common CHA core competencies, generated a theoretically based measure of those competencies, and explored psychometric properties of that measure. A concept synthesis revealed five CHA core competencies (leadership, translation, guidance, advocacy, and caring). The CHA Core Competency Retrospective Pretest/Posttest (CCCRP) resulted from that synthesis, which was administered using multiple approaches to individuals who previously received CHA training (N= 142). Exploratory factor analyses revealed a two-factor structure underlying the posttraining data, and Cronbach's alpha indicated high internal consistency. This study suggested some CHA core competencies might be more interrelated than previously thought, and two major competencies exist rather than five and supported the CCCRP's use to evaluate core competency attainment resulting from training. © The Author(s) 2014.

Synthesis of Axial Power Distribution Using 5-Level Ex-core Detector in a Core Protection System

International Nuclear Information System (INIS)

Koo, Bon-Seung; Lee, Chung-Chan; Zee, Sung-Quun

2007-01-01

In ABB-CE digital plants, Core Protection Calculator System (CPCS) is used for a core protection based on several online measured system parameters including 3- level safety grade ex-core detector signals. The CPCS provides four independent channels for the departure from a nucleate boiling ratio (DNBR) and local power density (LPD) trip signals to the reactor protection system. Each channel consists of a core protection calculator (CPC) and a control element assembly calculator (CEAC). The cubic spline synthesis technique has been used in online calculations of the core axial power distributions using 3-level ex-core detector signals in CPC. The pre-determined cubic spline function sets are used depending on the characteristics of the ex-core detector responses. But this method shows large power distribution errors for the extremely skewed axial shapes due to restrictive function sets and an incorrect SAM value. Especially thus situation is worse at a higher burnup. To solve these problems, the cubic spline function sets are improved and it is demonstrated that the axial power shapes can be synthesized more accurately with the new function sets than those of a conventional CPC. In this paper, synthesis of an axial power distribution using a 5-level ex-core detector is described and the axial power distributions are compared between 3-level and 5-level ex-core detector systems

Reactor core structure

International Nuclear Information System (INIS)

Higashinakagawa, Emiko; Sato, Kanemitsu.

1992-01-01

Taking notice on the fact that Fe based alloys and Ni based alloys are corrosion resistant in a special atmosphere of a nuclear reactor, Fe or Ni based alloys are applied to reactor core structural components such as fuel cladding tubes, fuel channels, spacers, etc. On the other hand, the neutron absorption cross section of zirconium is 0.18 barn while that of iron is 2.52 barn and that of nickel is 4.6 barn, which amounts to 14 to 25 times compared with that of zirconium. Accordingly, if the reactor core structural components are constituted by the Fe or Ni based alloys, neutron economy is lowered. Since it is desirable that neutrons contribute to uranium fission with least absorption to the reactor core structural components, the reactor core structural components are constituted with the Fe or Ni based alloys of good corrosion resistance only at a portion in contact with reactor water, that is, at a surface portion, while the main body is constituted with zircalloy in the present invention. Accordingly, corrosion resistnace can be kept while keeping small neutron absorption cross section. (T.M.)

Nuclear reactor with several cores

International Nuclear Information System (INIS)

Swars, H.

1977-01-01

Several sodium-cooled cores in separate vessels with removable closures are placed in a common reactor tank. Each individual vessel is protected against the consequences of an accident in the relevant core. Maintenance devices and inlet and outlet pipes for the coolant are also arranged within the reactor tank. The individual vessels are all enclosed by coolant in a way that in case of emergency cooling or refuelling each core can be continued to be cooled by means of the coolant loops of the other cores. (HP) [de

TMI-2 core debris analysis

International Nuclear Information System (INIS)

Cook, B.A.; Carlson, E.R.

1985-01-01

One of the ongoing examination tasks for the damaged TMI-2 reactor is analysis of samples of debris obtained from the debris bed presently at the top of the core. This paper summarizes the results reported in the TMI-2 Core Debris Grab Sample Examination and Analysis Report, which will be available early in 1986. The sampling and analysis procedures are presented, and information is provided on the key results as they relate to the present core condition, peak temperatures during the transient, temperature history, chemical interactions, and core relocation. The results are then summarized

Conceptual study of advanced PWR core design

International Nuclear Information System (INIS)

Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong.

1997-09-01

The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs

Conceptual study of advanced PWR core design

Energy Technology Data Exchange (ETDEWEB)

Kim, Young Jin; Chang, Moon Hee; Kim, Keung Ku; Joo, Hyung Kuk; Kim, Young Il; Noh, Jae Man; Hwang, Dae Hyun; Kim, Taek Kyum; Yoo, Yon Jong

1997-09-01

The purpose of this project is for developing and verifying the core design concepts with enhanced safety and economy, and associated methodologies for core analyses. From the study of the sate-of-art of foreign advanced reactor cores, we developed core concepts such as soluble boron free, high convertible and enhanced safety core loaded semi-tight lattice hexagonal fuel assemblies. To analyze this hexagonal core, we have developed and verified some neutronic and T/H analysis methodologies. HELIOS code was adopted as the assembly code and HEXFEM code was developed for hexagonal core analysis. Based on experimental data in hexagonal lattices and the COBRA-IV-I code, we developed a thermal-hydraulic analysis code for hexagonal lattices. Using the core analysis code systems developed in this project, we designed a 600 MWe core and studied the feasibility of the core concepts. Two additional scopes were performed in this project : study on the operational strategies of soluble boron free core and conceptual design of large scale passive core. By using the axial BP zoning concept and suitable design of control rods, this project showed that it was possible to design a soluble boron free core in 600 MWe PWR. The results of large scale core design showed that passive concepts and daily load follow operation could be practiced. (author). 15 refs., 52 tabs., 101 figs.

Maximum stellar iron core mass

Indian Academy of Sciences (India)

60, No. 3. — journal of. March 2003 physics pp. 415–422. Maximum stellar iron core mass. F W GIACOBBE. Chicago Research Center/American Air Liquide ... iron core compression due to the weight of non-ferrous matter overlying the iron cores within large .... thermal equilibrium velocities will tend to be non-relativistic.

Reactor core fuel management

International Nuclear Information System (INIS)

Silvennoinen, P.

1976-01-01

The subject is covered in chapters, entitled: concepts of reactor physics; neutron diffusion; core heat transfer; reactivity; reactor operation; variables of core management; computer code modules; alternative reactor concepts; methods of optimization; general system aspects. (U.K.)

Inner core tilt and polar motion

Science.gov (United States)

Dumberry, Mathieu; Bloxham, Jeremy

2002-11-01

A tilted inner core permits exchange of angular momentum between the core and the mantle through gravitational and pressure torques and, as a result, changes in the direction of Earth's axis of rotation with respect to the mantle. We have developed a model to calculate the amplitude of the polar motion that results from an equatorial torque at the inner core boundary which tilts the inner core out of alignment with the mantle. We specifically address the issue of the role of the inner core tilt in the decade polar motion known as the Markowitz wobble. We show that a decade polar motion of the same amplitude as the observed Markowitz wobble requires a torque of 1020 N m which tilts the inner core by 0.07 degrees. This result critically depends on the viscosity of the inner core; for a viscosity less than 5 × 1017 Pa s, larger torques are required. We investigate the possibility that a torque of 1020 N m with decadal periodicity can be produced by electromagnetic coupling between the inner core and torsional oscillations of the flow in the outer core. We demonstrate that a radial magnetic field at the inner core boundary of 3 to 4 mT is required to obtain a torque of such amplitude. The resulting polar motion is eccentric and polarized, in agreement with the observations. Our model suggests that equatorial torques at the inner core boundary might also excite the Chandler wobble, provided there exists a physical mechanism that can generate a large torque at a 14 month period.

Nuclear characteristic simulation device for reactor core

International Nuclear Information System (INIS)

Arakawa, Akio; Kobayashi, Yuji.

1994-01-01

In a simulation device for nuclear characteristic of a PWR type reactor, there are provided a one-dimensional reactor core dynamic characteristic model for simulating one-dimensional neutron flux distribution in the axial direction of the reactor core and average reactor power based on each of inputted signals of control rod pattern, a reactor core flow rate, reactor core pressure and reactor core inlet enthalphy, and a three-dimensional reactor core dynamic characteristic mode for simulating three-dimensional power distribution of the reactor core, and a nuclear instrumentation model for calculating read value of the nuclear instrumentation disposed in the reactor based on the average reactor core power and the reactor core three-dimensional power distribution. A one-dimensional neutron flux distribution in the axial direction of the reactor core, a reactor core average power, a reactor core three-dimensional power distribution and a nuclear instrumentation read value are calculated. As a result, the three-dimensional power distribution and the power level are continuously calculated. Further, since the transient change of the three-dimensional neutron flux distribution is calculated accurately on real time, more actual response relative to a power monitoring device of the reactor core and operation performance can be simulated. (N.H.)

Lateral restraint assembly for reactor core

Science.gov (United States)

Gorholt, Wilhelm; Luci, Raymond K.

1986-01-01

A restraint assembly for use in restraining lateral movement of a reactor core relative to a reactor vessel wherein a plurality of restraint assemblies are interposed between the reactor core and the reactor vessel in circumferentially spaced relation about the core. Each lateral restraint assembly includes a face plate urged against the outer periphery of the core by a plurality of compression springs which enable radial preloading of outer reflector blocks about the core and resist low-level lateral motion of the core. A fixed radial key member cooperates with each face plate in a manner enabling vertical movement of the face plate relative to the key member but restraining movement of the face plate transverse to the key member in a plane transverse to the center axis of the core. In this manner, the key members which have their axes transverse to or subtending acute angles with the direction of a high energy force tending to move the core laterally relative to the reactor vessel restrain such lateral movement.

TMI-2 core boring machine

International Nuclear Information System (INIS)

Croft, K.M.; Helbert, H.J.; Laney, W.M.

1986-01-01

An important and essential aspect of the TMI-2 defueling effort is to determine what occurred in the core region during the accident. Remote cameras and probes only portray a portion of the overall picture. What lies beneath the rubble bed and solidified sublayer is, as yet, unknown. This paper discusses the TMI-2 Core Boring Machine, which has been developed to drill into the damaged core of the TMI-2 reactor and extract stratified samples of the core. This machine, its unique support structure, positioning and leveling systems, and specially designed drill bits, combine to provide a unique mechanical system. In addition, the machine is controlled by a microprocessor; which actually controls the drilling operation, allowing relatively inexperienced operators to drill the core samples. A data acquisition system is data integral with the controlling system and collects data relative to system conditions and monitored parameters during drilling. Data obtained during the actual drilling operations are collected in a data base which will be used for actual mapping of the core region, identifying materials and stratification levels that are present

Wire core reactor for NTP

International Nuclear Information System (INIS)

Harty, R.B.

1991-01-01

The development of the wire core system for Nuclear Thermal Propulsion (NTP) that took place from 1963 to 1965 is discussed. A wire core consists of a fuel wire with spacer wires. It's an annular flow core having a central control rod. There are actually four of these, with beryllium solid reflectors on both ends and all the way around. Much of the information on the concept is given in viewgraph form. Viewgraphs are presented on design details of the wire core, the engine design, engine weight vs. thrust, a technique used to fabricate the wire fuel element, and axial temperature distribution

Core barrel inner tube lifter

Energy Technology Data Exchange (ETDEWEB)

Jeffers, J P

1968-07-16

A core drill with means for selectively lifting a core barrel inner tube consists of a lifting means connected to the core barrel inner tube assembly. It has a closable passage to permit drilling fluid normally to pass through it. The lifting means has a normally downward facing surface and a means to direct drilling fluid pressure against that surface so that on closure of the passage to fluid flow, the pressure of the drilling fluid is caused to act selectively on it. This causes the lifting means to rise and lift the core barrel. (7 claims)

Drilling history core hole DC-4

International Nuclear Information System (INIS)

1978-12-01

Core hole DC-4 was completed at a depth of 3998 feet in December, 1978 by Boyles Brothers Drilling Company, Spokane, Washington, under subcontract to Fenix and Scission, Inc. The hole was cored for the US Department of Energy and the Rockwell Hanford Operations' Basalt Waste Isolation Program. Fenix and Sicsson, Inc. furnished the engineering, daily supervision of the cable tool and core drilling activities, and geological core logging for DC-4. Core hole DC-4 is located on the Hanford Site about 3 miles east of the Yakima Barricade and approximately 103 feet southwest of rotary hole DC-5, which was completed to 3990 feet in February, 1978. Hanford Site coordinates reported for hole DC-4 are north 49,385.62 feet and west 85,207.63 feet, and Washington State coordinates are north 454,468.73 feet and east 2,209,990.87 feet. No elevation survey is available for hole DC-4, but it is approximately 745 feet above mean sea level based upon the survey of hole DC-5, which has a reported elevation of 745.16 feet on the top of the 3-inch flange. The purpose of core hole DC-4 was to core drill vertically through the basalt and interbed units for stratigraphic depth determination and core collection, and to provide a borehole for hydrologic testing, cross-hole seismic shear, and pressure wave velocity studies with rotary hole DC-5. Hole DC-4 was drilled through the overburden into basalt bedrock by cable tool methods (0-623 feet) and continuously cored through the final interval (623 to 3998 feet).Core recovery was 95.8 percent of the total footage cored

DENSE MOLECULAR CORES BEING EXTERNALLY HEATED

Energy Technology Data Exchange (ETDEWEB)

Kim, Gwanjeong; Lee, Chang Won; Kim, Mi-Ryang [Radio Astronomy division, Korea Astronomy and Space Science Institute, 776 Daedeokdae-ro, Yuseong-gu, Daejeon, 34055 (Korea, Republic of); Gopinathan, Maheswar [Aryabhatta Research Institute of Observational Sciences, Manora Peak, Nainital 263129 (India); Jeong, Woong-Seob, E-mail: archer81@kasi.re.kr [Department of Astronomy and Space Science, University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, 34113 (Korea, Republic of)

2016-06-20

We present results of our study of eight dense cores, previously classified as starless, using infrared (3–160 μ m) imaging observations with the AKARI telescope and molecular line (HCN and N{sub 2}H{sup +}) mapping observations with the KVN telescope. Combining our results with the archival IR to millimeter continuum data, we examined the starless nature of these eight cores. Two of the eight cores are found to harbor faint protostars having luminosities of ∼0.3–4.4 L {sub ⊙}. The other six cores are found to remain starless and probably are in a dynamically transitional state. The temperature maps produced using multi-wavelength images show an enhancement of about 3–6 K toward the outer boundary of these cores, suggesting that they are most likely being heated externally by nearby stars and/or interstellar radiation fields. Large virial parameters and an overdominance of red asymmetric line profiles over the cores may indicate that the cores are set into either an expansion or an oscillatory motion, probably due to the external heating. Most of the starless cores show a coreshine effect due to the scattering of light by the micron-sized dust grains. This may imply that the age of the cores is of the order of ∼10{sup 5} years, which is consistent with the timescale required for the cores to evolve into an oscillatory stage due to external perturbation. Our observational results support the idea that the external feedback from nearby stars and/or interstellar radiation fields may play an important role in the dynamical evolution of the cores.

Fuel and core design study of the sodium-cooled fast reactors. Studies on metallic fuel cores in the JFY2002

International Nuclear Information System (INIS)

Sugino, Kazuteru; Mizuno, Tomoyasu

2003-06-01

Based on the results obtained in the former feasibility study, the metallic fueled core of ordinary-type, that is, 2-region homogeneous core, has been established aiming at the improvement in the core performance, and subsequent comparison has been performed with the mixed oxide fueled core. Further, the attractive concept of the metallic fueled core of high outlet temperature has been constructed which has good nuclear features as a metallic fueled core and has identical outlet temperature to mixed oxide fuelled core. Following items have been found as a result of the investigation on the ordinary-type core. The metallic fueled core whose maximum fast neutron fluence (En>0.1MeV) is set identical (5x10 23 n/cm 2 ) to the mixed oxide fueled cores with core discharge burnup 150GWd/t has sufficient core performances as a metallic fueled core, e.g. higher breeding ratio and longer operation period compared with mixed oxide fueled cores, but the core discharge burnup is limited up to 100GWd/t. However effective discharge burnup including the contribution of the blanket region is comparative to mixed oxide cores under the same breeding ratio condition. In order to enlarge the core discharge burnup to 150GWd/t keeping the core performance identical to above mentioned core's, the irradiation deformation of structural material should be reduced to that of mixed oxide fueled cores. Further the maximum fast neutron fluence reaches to 7-8x10 23 n/cm 2 (En>0.1MeV). The investigations on the core of high outlet temperature have clarified following items. Even in the change of core regions by pin-diameter form 3-region to 2-region and in the limited maximum fuel pin diameter 8.5 mm, realization of the identical outlet/inlet temperatures to the mixed oxide cores (550/395degC) is feasible under the criteria of the maximum temperature 650degC at the inner surface of the cladding. The constructed core accommodates the targets of breeding ratio from about 1.0 to 1.2 only by adjusting

Design configuration of GCFR core assemblies

International Nuclear Information System (INIS)

LaBar, M.P.; Lee, G.E.; Meyer, R.J.

1980-05-01

The current design configurations of the core assemblies for the gas-cooled fast reactor (GCFR) demonstration plant reactor core conceptual design are described. Primary emphasis is placed upon the design innovations that have been incorporated in the design of the core assemblies since the establishment of the initial design of an upflow GCFR core. A major feature of the design configurations is that they are prototypical of core assemblies for use in commercial plants; a larger number of the same assemblies would be used in a commercial plant

Double U-Core Switched Reluctance Machine

DEFF Research Database (Denmark)

2016-01-01

The present invention relates to an electrical machine stator comprising a plurality of stator segments (131,132,133), each segment comprises a first U-core and a second U-core wound with a winding, where the winding being arranged with at least one coil turn, each coil turn comprises a first axial......(s), wherein the first U-core and the second U-core are located adjacent to each other, whereby the winding spans the first and second U-cores. The invention also relates to a SRM machine with a stator mentioned above and a rotor....

Development of coring, consolidating, subterrene penetrators

International Nuclear Information System (INIS)

Murphy, H.D.; Neudecker, J.W.; Cort, G.E.; Turner, W.C.; McFarland, R.D.; Griggs, J.E.

1976-02-01

Coring penetrators offer two advantages over full face-melting penetrators, i.e., formation of larger boreholes with no increase in power and the production of glass-lined, structurally undisturbed cores which can be recovered with conventional core-retrieval systems. These cores are of significant value in geological exploratory drilling programs. The initial design details and fabrication features of a 114-mm-diam coring penetrator are discussed; significant factors for design optimization are also presented. Results of laboratory testing are reported and compared with performance predictions, and an initial field trial is described

Ice core carbonyl sulfide measurements from a new South Pole ice core (SPICECORE)

Science.gov (United States)

Aydin, M.; Nicewonger, M. R.; Saltzman, E. S.

2017-12-01

Carbonyl sulfide (COS) is the most abundant sulfur gas in the troposphere with a present-day mixing ratio of about 500 ppt. Direct and indirect emissions from the oceans are the predominant sources of atmospheric COS. The primary removal mechanism is uptake by terrestrial plants during photosynthesis. Because plants do not respire COS, atmospheric COS levels are linked to terrestrial gross primary productivity (GPP). Ancient air trapped in polar ice cores has been used to reconstruct COS records of the past atmosphere, which can be used to infer past GPP variability and potential changes in oceanic COS emission. We are currently analyzing samples from a newly drilled intermediate depth ice core from South Pole, Antarctica (SPICECORE). This core is advantageous for studying COS because the cold temperatures of South Pole ice lead to very slow rates of in situ loss due to hydrolysis. One hundred and eighty-four bubbly ice core samples have been analyzed to date with gas ages ranging from about 9.2 thousand (733 m depth) to 75 years (126 m depth) before present. After a 2% correction for gravitational enrichment in the firn, the mean COS mixing ratio for the data set is 312±15 ppt (±1s), with the data set median also equal to 312 ppt. The only significant long-term trend in the record is a 5-10% increase in COS during the last 2-3 thousand years of the Holocene. The SPICECORE data agree with previously published ice core COS records from other Antarctic sites during times of overlap, confirming earlier estimates of COS loss rates to in situ hydrolysis in ice cores. Antarctic ice core data place strict constraints on the COS mixing ratio and its range of variability in the southern hemisphere atmosphere during the last several millennia. Implications for the atmospheric COS budget will be discussed.

The Expanded FindCore Method for Identification of a Core Atom Set for Assessment of Protein Structure Prediction

Science.gov (United States)

Snyder, David A.; Grullon, Jennifer; Huang, Yuanpeng J.; Tejero, Roberto; Montelione, Gaetano T.

2014-01-01

Maximizing the scientific impact of NMR-based structure determination requires robust and statistically sound methods for assessing the precision of NMR-derived structures. In particular, a method to define a core atom set for calculating superimpositions and validating structure predictions is critical to the use of NMR-derived structures as targets in the CASP competition. FindCore (D.A. Snyder and G.T. Montelione PROTEINS 2005;59:673–686) is a superimposition independent method for identifying a core atom set, and partitioning that set into domains. However, as FindCore optimizes superimposition by sensitively excluding not-well-defined atoms, the FindCore core may not comprise all atoms suitable for use in certain applications of NMR structures, including the CASP assessment process. Adapting the FindCore approach to assess predicted models against experimental NMR structures in CASP10 required modification of the FindCore method. This paper describes conventions and a standard protocol to calculate an “Expanded FindCore” atom set suitable for validation and application in biological and biophysical contexts. A key application of the Expanded FindCore method is to identify a core set of atoms in the experimental NMR structure for which it makes sense to validate predicted protein structure models. We demonstrate the application of this Expanded FindCore method in characterizing well-defined regions of 18 NMR-derived CASP10 target structures. The Expanded FindCore protocol defines “expanded core atom sets” that match an expert’s intuition of which parts of the structure are sufficiently well-defined to use in assessing CASP model predictions. We also illustrate the impact of this analysis on the CASP GDT assessment scores. PMID:24327305

Under sodium reliability tests on core components and in-core instrumentation

International Nuclear Information System (INIS)

Ruppert, E.; Stehle, H.; Vinzens, K.

1977-01-01

A sodium test facility for fast breeder core components (AKB), built by INTERATOM at Bensberg, has been operating since 1971 to test fuel dummies and blanket elements as well as absorber elements under simulated normal and extreme reactor conditions. Individual full-scale fuel or blanket elements and arrays of seven elements, modelling a section of the SNR-300 reactor core, have been tested under a wide range of sodium mass flow and isothermal test conditions up to 925K as well as under cyclic changed temperature transients. Besides endurance testing of the core components a special sodium and high-temperature instrumentation is provided to investigate thermohydraulic and vibrational behaviour of the test objects. During all test periods the main subassembly characteristics could be reproduced and the reliability of the instrumentation could be proven. (orig.) [de

Reactor core for LMFBR type reactors

International Nuclear Information System (INIS)

Masumi, Ryoji; Azekura, Kazuo; Kurihara, Kunitoshi; Bando, Masaru; Watari, Yoshio.

1987-01-01

Purpose: To reduce the power distribution fluctuations and obtain flat and stable power distribution throughout the operation period in an LMFBR type reactor. Constitution: In the inner reactor core region and the outer reactor core region surrounding the same, the thickness of the inner region is made smaller than the axial height of the reactor core region and the radial width thereof is made smaller than that of the reactor core region and the volume thereof is made to 30 - 50 % for the reactor core region. Further, the amount of the fuel material per unit volume in the inner region is made to 70 - 90 % of that in the outer region. The difference in the neutron infinite multiplication factor between the inner region and the outer region is substantially constant irrespective of the burnup degree and the power distribution fluctuation can be reduced to about 2/3, by which the effect of thermal striping to the reactor core upper mechanisms can be moderated. Further, the maximum linear power during operation can be reduced by 3 %, by which the thermal margin in the reactor core is increased and the reactor core fuels can be saved by 3 %. (Kamimura, M.)

Core supervision methods and future improvements of the core master/presto system at KKB

International Nuclear Information System (INIS)

Lundberg, S.; Wenisch, J.; Teeffelen, W.V.

2000-01-01

Kernkraftwerk Brunsbuettel (KKB) is a KWU 806 MW e BWR located at the lower river Elbe, in Germany. The reactor has been in operation since 1976 and is now operating in its 14. cycle. The core supervision at KKB is performed with the ABB CORE MASTER system. This system mainly contains the 3-D simulator PRESTO supplied by Studsvik Scandpower A/S. The core supervision is performed by periodic PRESTO 3-D evaluations of the reactor operation state. The power distribution calculated by PRESTO is adapted with the ABB UPDAT program using the on-line LPRM readings. The thermal margins are based on this adapted power distribution. Related to core supervision, the function of the PRESTO/UPDAT codes is presented. The UPDAT method is working well and is capable of reproducing the true core power distribution. The quality of the 3-D calculation is, however, an important ingredient of the quality of the adapted power distribution. The adaptation method as such is also important for this quality. The data quality of this system during steady state and off-rate states (reactor manoeuvres) are discussed by presenting comparisons between PRESTO and UPDAT thermal margin utilisation from Cycle 13. Recently analysed asymmetries in the UPDAT evaluated MCPR values are also presented and discussed. Improvements in the core supervision such as the introduction of advanced modern nodal methods (PRESTO-2) are presented and an alternative core supervision philosophy is discussed. An ongoing project with the goal to update the data and result presentation interface (GUI) is also presented. (authors)

Constraints on The Coupled Thermal Evolution of the Earth's Core and Mantle, The Age of The Inner Core, And The Origin of the 186Os/188Os Core(?) Signal in Plume-Derived Lavas

Science.gov (United States)

Lassiter, J. C.

2005-12-01

Thermal and chemical interaction between the core and mantle has played a critical role in the thermal and chemical evolution of the Earth's interior. Outer core convection is driven by core cooling and inner core crystallization. Core/mantle heat transfer also buffers mantle potential temperature, resulting in slower rates of mantle cooling (~50-100 K/Ga) than would be predicted from the discrepancy between current rates of surface heat loss (~44 TW) and internal radioactive heat production (~20 TW). Core/mantle heat transfer may also generate thermal mantle plumes responsible for ocean island volcanic chains such as the Hawaiian Islands. Several studies suggest that mantle plumes, in addition to transporting heat from the core/mantle boundary, also carry a chemical signature of core/mantle interaction. Elevated 186Os/188Os ratios in lavas from Hawaii, Gorgona, and in the 2.8 Ga Kostomuksha komatiites have been interpreted as reflecting incorporation of an outer core component with high time-integrated Pt/Os and Re/Os ( Brandon et al., 1999, 2003; Puchtel et al., 2005). Preferential partitioning of Os relative to Re and Pt into the inner core during inner core growth may generate elevated Re/Os and Pt/Os ratios in the residual outer core. Because of the long half-life of 190Pt (the parent of 186Os, t1/2 = 489 Ga), an elevated 186Os/188Os outer core signature in plume lavas requires that inner core crystallization began early in Earth history, most likely prior to 3.5 Ga. This in turn requires low time-averaged core/mantle heat flow (<~2.5 TW) or large quantities of heat-producing elements in the core. Core/mantle heat flow may be estimated using boundary-layer theory, by measuring the heat transported in mantle plumes, by estimating the heat transported along the outer core adiabat, or by comparing the rates of heat production, surface heat loss, and secular cooling of the mantle. All of these independent methods suggest time-averaged core/mantle heat flow of ~5

Core Processes: Earth's eccentric magnetic field

DEFF Research Database (Denmark)

Finlay, Chris

2012-01-01

Earth’s magnetic field is characterized by a puzzling hemispheric asymmetry. Calculations of core dynamo processes suggest that lopsided growth of the planet’s inner core may be part of the cause.......Earth’s magnetic field is characterized by a puzzling hemispheric asymmetry. Calculations of core dynamo processes suggest that lopsided growth of the planet’s inner core may be part of the cause....

Calculation of core loss and copper loss in amorphous/nanocrystalline core-based high-frequency transformer

Directory of Open Access Journals (Sweden)

Xiaojing Liu

2016-05-01

Full Text Available Amorphous and nanocrystalline alloys are now widely used for the cores of high-frequency transformers, and Litz-wire is commonly used as the windings, while it is difficult to calculate the resistance accurately. In order to design a high-frequency transformer, it is important to accurately calculate the core loss and copper loss. To calculate the core loss accurately, the additional core loss by the effect of end stripe should be considered. It is difficult to simulate the whole stripes in the core due to the limit of computation, so a scale down model with 5 stripes of amorphous alloy is simulated by the 2D finite element method (FEM. An analytical model is presented to calculate the copper loss in the Litz-wire, and the results are compared with the calculations by FEM.

Radio core dominance of Fermi blazars

Science.gov (United States)

Pei, Zhi-Yuan; Fan, Jun-Hui; Liu, Yi; Yuan, Yi-Hai; Cai, Wei; Xiao, Hu-Bing; Lin, Chao; Yang, Jiang-He

2016-07-01

During the first 4 years of mission, Fermi/LAT detected 1444 blazars (3FGL) (Ackermann et al. in Astrophys. J. 810:14, 2015). Fermi/LAT observations of blazars indicate that Fermi blazars are luminous and strongly variable with variability time scales, for some cases, as short as hours. Those observations suggest a strong beaming effect in Fermi/LAT blazars. In the present work, we will investigate the beaming effect in Fermi/LAT blazars using a core-dominance parameter, R = S_{core}/ S_{ext.}, where S_{core} is the core emission, while S_{ext.} is the extended emission. We compiled 1335 blazars with available core-dominance parameter, out of which 169 blazars have γ-ray emission (from 3FGL). We compared the core-dominance parameters, log R, between the 169 Fermi-detected blazars (FDBs) and the rest non-Fermi-detected blazars (non-FDBs), and we found that the averaged values are R+(2.25±0.10), suggesting that a source with larger log R has larger V.I. value. Thirdly, we compared the mean values of radio spectral index for FDBs and non-FDBs, and we obtained < α_{radio}rangle =0.06±0.35 for FDBs and < α_{radio}rangle =0.57±0.46 for non-FDBs. If γ-rays are composed of two components like radio emission (core and extended components), then we can expect a correlation between log R and the γ-ray spectral index. When we used the radio core-dominance parameter, log R, to investigate the relationship, we found that the spectral index for the core component is α_{γ}|_{core} = 1.11 (a photon spectral index of α_{γ}^{ph}|_{core} = 2.11) and that for the extended component is α_{γ}|_{ext.} = 0.70 (a photon spectral index of α_{γ}^{ph}|_{ext.} = 1.70). Some discussions are also presented.

Engineered inorganic core/shell nanoparticles

Energy Technology Data Exchange (ETDEWEB)

Mélinon, Patrice, E-mail: patrice.melinon@univ-lyon1.fr [Institut Lumière matière Université Claude Bernard Lyon 1 et CNRS et OMNT, Domaine Scientifique de la Doua, Bâtiment Léon Brillouin, 43 Boulevard du 11 Novembre 1918, F 69622 Villeurbanne (France); Begin-Colin, Sylvie [IPCMS et OMNT, 23 rue du Loess BP 43, 67034 STRASBOURG Cedex 2 (France); Duvail, Jean Luc [IMN UMR 6502 et OMNT Campus Sciences : 2 rue de la Houssinire, BP32229, 44322 Nantes Cedex3 (France); Gauffre, Fabienne [SPM et OMNT : Institut des sciences chimiques de Rennes - UMR 6226, 263 Avenue du General Leclerc, CS 74205, 35042 RENNES Cedex (France); Boime, Nathalie Herlin [IRAMIS-NIMBE, Laboratoire Francis Perrin (CEA CNRS URA 2453) et OMNT, Bat 522, CEA Saclay, 91191 Gif sur Yvette Cedex (France); Ledoux, Gilles [Institut Lumière Matière Université Claude Bernard Lyon 1 et CNRS et OMNT, Domaine Scientifique de la Doua, Bâtiment Alfred Kastler 43 Boulevard du 11 Novembre 1918 F 69622 Villeurbanne (France); Plain, Jérôme [Universit de technologie de Troyes LNIO-ICD, CNRS et OMNT 12 rue Marie Curie - CS 42060 - 10004 Troyes cedex (France); Reiss, Peter [CEA Grenoble, INAC-SPrAM, UMR 5819 CEA-CNRS-UJF et OMNT, Grenoble cedex 9 (France); Silly, Fabien [CEA, IRAMIS, SPEC, TITANS, CNRS 2464 et OMNT, F-91191 Gif sur Yvette (France); Warot-Fonrose, Bénédicte [CEMES-CNRS, Université de Toulouse et OMNT, 29 rue Jeanne Marvig F 31055 Toulouse (France)

2014-10-20

It has been for a long time recognized that nanoparticles are of great scientific interest as they are effectively a bridge between bulk materials and atomic structures. At first, size effects occurring in single elements have been studied. More recently, progress in chemical and physical synthesis routes permitted the preparation of more complex structures. Such structures take advantages of new adjustable parameters including stoichiometry, chemical ordering, shape and segregation opening new fields with tailored materials for biology, mechanics, optics magnetism, chemistry catalysis, solar cells and microelectronics. Among them, core/shell structures are a particular class of nanoparticles made with an inorganic core and one or several inorganic shell layer(s). In earlier work, the shell was merely used as a protective coating for the core. More recently, it has been shown that it is possible to tune the physical properties in a larger range than that of each material taken separately. The goal of the present review is to discuss the basic properties of the different types of core/shell nanoparticles including a large variety of heterostructures. We restrict ourselves on all inorganic (on inorganic/inorganic) core/shell structures. In the light of recent developments, the applications of inorganic core/shell particles are found in many fields including biology, chemistry, physics and engineering. In addition to a representative overview of the properties, general concepts based on solid state physics are considered for material selection and for identifying criteria linking the core/shell structure and its resulting properties. Chemical and physical routes for the synthesis and specific methods for the study of core/shell nanoparticle are briefly discussed.

Design Report for the core design of the first core Mark-Ia of the SNR-300

International Nuclear Information System (INIS)

Stanculescu, A.

1984-05-01

The report describes the first core Mark-Ia of the SNR-300 reactor and its different assembly types with their operational strategy. Methods, criteria and results of the neutron physical, thermal hydraulic and core mechanical design of the whole core and its assemblies are presented

Hydrophilic-Core Microcapsules and Their Formation

Science.gov (United States)

Calle, Luz M. (Inventor); Li, Wenyan (Inventor); Buhrow, Jerry W. (Inventor); Jolley, Scott T. (Inventor)

2016-01-01

Hydrophilic-core microcapsules and methods of their formation are provided. A hydrophilic-core microcapsule may include a shell that encapsulates water with the core substance dissolved or dispersed therein. The hydrophilic-core microcapsules may be formed from an emulsion having hydrophilic-phase droplets dispersed in a hydrophobic phase, with shell-forming compound contained in the hydrophilic phase or the hydrophobic phase and the core substance contained in the hydrophilic phase. The shells of the microcapsules may be capable of being broken down in response to being contacted by an alkali, e.g., produced during corrosion, contacting the shell.

Hydrophobic-Core Microcapsules and Their Formation

Science.gov (United States)

Calle, Luz M. (Inventor); Li, Wenyan (Inventor); Buhrow, Jerry W. (Inventor); Jolley, Scott T. (Inventor)

2016-01-01

Hydrophobic-core microcapsules and methods of their formation are provided. A hydrophobic-core microcapsule may include a shell that encapsulates a hydrophobic substance with a core substance, such as dye, corrosion indicator, corrosion inhibitor, and/or healing agent, dissolved or dispersed therein. The hydrophobic-core microcapsules may be formed from an emulsion having hydrophobic-phase droplets, e.g., containing the core substance and shell-forming compound, dispersed in a hydrophilic phase. The shells of the microcapsules may be capable of being broken down in response to being contacted by an alkali, e.g., produced during corrosion, contacting the shell.

Fort St. Vrain core performance

International Nuclear Information System (INIS)

McEachern, D.W.; Brown, J.R.; Heller, R.A.; Franek, W.J.

1977-07-01

The Fort St. Vrain High Temperature Gas Cooled Reactor core performance has been evaluated during the startup testing phase of the reactor operation. The reactor is graphite moderated, helium cooled, and uses coated particle fuel and on-line flow control to each of the 37 refueling regions. Principal objectives of startup testing were to determine: core and control system reactivity, radial power distribution, flow control capability, and initial fission product release. Information from the core demonstrates that Technical Specifications are being met, performance of the core and fuel is as expected, flow and reactivity control are predictable and simple for the operator to carry out

Evaluation of downmotion time interval molten materials to core catcher during core disruptive accidents postulated in LMFR

International Nuclear Information System (INIS)

Voronov, S.A.; Kiryushin, A.I.; Kuzavkov, N.G.; Vlasichev, G.N.

1994-01-01

Hypothetical core disruptive accidents are postulated to clear potential of a reactor plant to withstand extreme conditions and to generate measures for management and mitigation of accidents consequence. In Russian advanced reactors there is a core catcher below the diagrid to prevent vessel bottom melting and to localize fuel debris. In this paper the calculation technique and estimation of relocation time of molten fuel and materials are presented in the case of core disruptive accidents postulated for LMFR reactor. To evaluate minimum interval of fuel relocation time the calculations for different initial data are provided. Large mass of materials between the core and the catcher in LMFR reactor hinders molten materials relocation toward the vessel bottom. That condition increases the time interval of reaching core catcher by molten fuel. Computations performed allowed to evaluate the minimum molten materials relocation time from the core to the core catcher. This time interval is in a range of 3.5-5.5 hours. (author)

Nuclear reactor core modelling in multifunctional simulators

International Nuclear Information System (INIS)

Puska, E.K.

1999-01-01

The thesis concentrates on the development of nuclear reactor core models for the APROS multifunctional simulation environment and the use of the core models in various kinds of applications. The work was started in 1986 as a part of the development of the entire APROS simulation system. The aim was to create core models that would serve in a reliable manner in an interactive, modular and multifunctional simulator/plant analyser environment. One-dimensional and three-dimensional core neutronics models have been developed. Both models have two energy groups and six delayed neutron groups. The three-dimensional finite difference type core model is able to describe both BWR- and PWR-type cores with quadratic fuel assemblies and VVER-type cores with hexagonal fuel assemblies. The one- and three-dimensional core neutronics models can be connected with the homogeneous, the five-equation or the six-equation thermal hydraulic models of APROS. The key feature of APROS is that the same physical models can be used in various applications. The nuclear reactor core models of APROS have been built in such a manner that the same models can be used in simulator and plant analyser applications, as well as in safety analysis. In the APROS environment the user can select the number of flow channels in the three-dimensional reactor core and either the homogeneous, the five- or the six-equation thermal hydraulic model for these channels. The thermal hydraulic model and the number of flow channels have a decisive effect on the calculation time of the three-dimensional core model and thus, at present, these particular selections make the major difference between a safety analysis core model and a training simulator core model. The emphasis on this thesis is on the three-dimensional core model and its capability to analyse symmetric and asymmetric events in the core. The factors affecting the calculation times of various three-dimensional BWR, PWR and WWER-type APROS core models have been

Nuclear reactor core modelling in multifunctional simulators

Energy Technology Data Exchange (ETDEWEB)

Puska, E.K. [VTT Energy, Nuclear Energy, Espoo (Finland)

1999-06-01

The thesis concentrates on the development of nuclear reactor core models for the APROS multifunctional simulation environment and the use of the core models in various kinds of applications. The work was started in 1986 as a part of the development of the entire APROS simulation system. The aim was to create core models that would serve in a reliable manner in an interactive, modular and multifunctional simulator/plant analyser environment. One-dimensional and three-dimensional core neutronics models have been developed. Both models have two energy groups and six delayed neutron groups. The three-dimensional finite difference type core model is able to describe both BWR- and PWR-type cores with quadratic fuel assemblies and VVER-type cores with hexagonal fuel assemblies. The one- and three-dimensional core neutronics models can be connected with the homogeneous, the five-equation or the six-equation thermal hydraulic models of APROS. The key feature of APROS is that the same physical models can be used in various applications. The nuclear reactor core models of APROS have been built in such a manner that the same models can be used in simulator and plant analyser applications, as well as in safety analysis. In the APROS environment the user can select the number of flow channels in the three-dimensional reactor core and either the homogeneous, the five- or the six-equation thermal hydraulic model for these channels. The thermal hydraulic model and the number of flow channels have a decisive effect on the calculation time of the three-dimensional core model and thus, at present, these particular selections make the major difference between a safety analysis core model and a training simulator core model. The emphasis on this thesis is on the three-dimensional core model and its capability to analyse symmetric and asymmetric events in the core. The factors affecting the calculation times of various three-dimensional BWR, PWR and WWER-type APROS core models have been

Advanced core monitoring technology for WWER reactors

International Nuclear Information System (INIS)

Nguyen, T.Q.; Casadei, A.L.; Doshi, P.K.

1993-01-01

The Westinghouse BEACON online monitoring system has been developed to provide continuous core monitoring and operational support for pressurized water reactor using movable detectors (fission chamber) and core thermocouples. The basic BEACON core monitoring methodology is described. Traditional WWER reactors use rhodium fixed in-core detectors as the means to provide detailed core power distribution for surveillance purposes. An adapted version of the BEACON advanced core monitoring and support system is described which seems to be, due to the different demand/response requirements, the optimal solution (for routine surveillance and anomaly detection) for WWER reactors with existing fixed in-core detectors. (Z.S.) 4 refs

ETRR-2 in-core fuel management strategy

International Nuclear Information System (INIS)

Khalil, M.Y.; Amin, Esmat; Belal, M.G.

2005-01-01

The Egypt second research reactor has many irradiation channels, beam tubes and irradiation boxes, inside and outside the reactor core. The core reload configuration has great effect on the core performance and fluxes in the irradiation channels. This paper deals with the design and safety analysis that were performed for the determination of ETRR2 in-core fuel management strategy which fulfills neutronic design criteria, safety reactor operation, utility optimization and achieve the overall fuel management criteria. The core is divided into 8 zones, in order to obtain the minimum and adjacent fuel movement scheme that is recommended from the operational point of view. Then a search for the initial core using backward iteration, one get different initial cores, one initial core would assume the equilibrium core after 250 full power days of operation, while the other assumes equilibrium after 199 full power days, and shows a better performance of power peaking factor. (author)

Epidemiology of organising pneumonia in Iceland

Science.gov (United States)

Gudmundsson, G; Sveinsson, O; Isaksson, H J; Jonsson, S; Frodadottir, H; Aspelund, T

2006-01-01

Background Cryptogenic organising pneumonia (COP) has also been called idiopathic bronchiolitis obliterans organising pneumonia. In secondary organising pneumonia (SOP) the causes can be identified or it occurs in a characteristic clinical context. The aim of this study was to determine the incidence and epidemiological features of COP and SOP nationwide in Iceland over an extended period. Methods A retrospective study of organising pneumonia (OP) in Iceland over 20 years was conducted and the epidemiology and survival were studied. All pathological reports of patients diagnosed with or suspected of having COP or SOP in the period 1984–2003 were identified and the pathology samples were re‐evaluated using strict diagnostic criteria. Results After re‐evaluation, 104 patients fulfilled the diagnostic criteria for OP (58 COP and 46 SOP). The mean annual incidence of OP was 1.97/100 000 population (1.10/100 000 for COP and 0.87/100 000 for SOP). The mean age at diagnosis was 67 years with a wide age range. The most common causes of death were lung diseases other than OP, and only one patient died from OP. Patients with OP had a lower rate of survival than the general population, but there was no statistical difference between COP and SOP. Conclusions The incidence of OP is higher than previously reported, suggesting that OP needs to be considered as a diagnosis more often than has been done in the past. PMID:16809413

Guideline for the preparation of safe operating procedures

International Nuclear Information System (INIS)

Stinnett, L.; Armbrust, E.F.; Christy, V.W.; Doyle, J.R.; Kesinger, J.H.

1977-03-01

Sandia Laboratories Safe Operating Procedures (SOP) are written for activities which involve the use of explosives, dangerous chemicals, radioactive materials, hazardous systems, and certain types of operational facilities which present hazards. This guideline presents a suggested SOP format

Arbitrary Control of Polarization and Intensity Profiles of Diffraction-Attenuation-Resistant Beams along the Propagation Direction

Science.gov (United States)

Corato-Zanarella, Mateus; Dorrah, Ahmed H.; Zamboni-Rached, Michel; Mojahedi, Mo

2018-02-01

We report on the theory and experimental generation of a class of diffraction-attenuation-resistant beams with state of polarization (SOP) and intensity that can be controlled on demand along the propagation direction. This control is achieved by a suitable superposition of Bessel beams, whose parameters are systematically chosen based on closed-form analytic expressions provided by the frozen waves method. Using an amplitude-only spatial light modulator, we experimentally demonstrate three scenarios. In the first, the SOP of a horizontally polarized beam evolves to radial polarization and is then changed to vertical polarization, with the beam intensity held constant. In the second, we simultaneously control the SOP and the longitudinal intensity profile, which is chosen such that the beam's central ring can be switched off over predefined space regions, thus generating multiple foci with different SOPs and at different intensity levels along the propagation. Finally, the ability to control the SOP while overcoming attenuation inside lossy fluids is shown experimentally. We envision our proposed method to be of great interest for many applications, such as optical tweezers, atom guiding, material processing, microscopy, and optical communications.

Analysis the Response Function of the HTR Ex-core Neutron Detectors in Different Core Status

International Nuclear Information System (INIS)

Fan Kai; Li Fu; Zhou Xuhua

2014-01-01

Modular high temperature gas cooled reactor HTR-PM demonstration plant, designed by INET, Tsinghua University, is being built in Shidao Bay, Shandong province, China. HTR-PM adopts pebble bed concept. The harmonic synthesis method has been developed to reconstruct the power distributions on HTR-PM. The method based on the assumption that the neutron detector readings are mainly determined by the status of the core through the power distribution, and the response functions changed little when the status of the core changed. To verify the assumption, the influence factors to the ex-core neutron detectors are calculated in this paper, including the control rod position and the temperature of the core. The results shows that when the status of the core changed, the power distribution changed more remarkable than the response function, but the detector readings could change about 5% because of the response function changing. (author)

Subharmonic excitation in an HTGR core

International Nuclear Information System (INIS)

Bezler, P.; Curreri, J.R.

1977-01-01

The occurrence of subharmonic resonance in a series of blocks with clearance between blocks and with springs on the outer most ends is the subject of this paper. This represents an HTGR core response to an earthquake input. An analytical model of the cross section of this type of core is a series of blocks arranged horizontally between outer walls. Each block represents many graphite hexagonal core elements acting in unison as a single mass. The blocks are of unequal size to model the true mass distribution through the core. Core element elasticity and damping characteristics are modeled with linear spring and viscous damping units affixed to each block. The walls and base represent the core barell or core element containment structure. For forced response calculations, these boundaries are given prescribed motions. The clearance between each block could be the same or different with the total clearance duplicating that of the entire core. Spring packs installed between the first and last block and the boundaries model the boundary elasticity. The system non-linearity is due to the severe discontinuity in the interblock elastic forces when adjacent blocks collide. A computer program using a numerical integration scheme was developed to solve for the response of the system to arbitrary inputs

Supplemental materials for the ICDP-USGS Eyreville A, B, and C core holes, Chesapeake Bay impact structure: Core-box photographs, coring-run tables, and depth-conversion files

Science.gov (United States)

Durand, C.T.; Edwards, L.E.; Malinconico, M.L.; Powars, D.S.

2009-01-01

During 2005-2006, the International Continental Scientific Drilling Program and the U.S. Geological Survey drilled three continuous core holes into the Chesapeake Bay impact structure to a total depth of 1766.3 m. A collection of supplemental materials that presents a record of the core recovery and measurement data for the Eyreville cores is available on CD-ROM at the end of this volume and in the GSA Data Repository. The supplemental materials on the CD-ROM include digital photographs of each core box from the three core holes, tables of the three coring-run logs, as recorded on site, and a set of depth-conversion programs. In this chapter, the contents, purposes, and basic applications of the supplemental materials are briefly described. With this information, users can quickly decide if the materials will apply to their specific research needs. ?? 2009 The Geological Society of America.

Development of CANDU core monitoring system

International Nuclear Information System (INIS)

Yoon, M. Y.; Yeam, C. S.; Kwon, O. H.; Kim, K. H.

2003-01-01

The research was performed to develop a CANDU Core Monitoring System(CCMS) that enables operators to have efficient core management by monitoring core power distribution, burnup distribution, and the other important core variables and managing the past core history for Wolsong Nuclear Power Plant(NPP) No. 1. CCMS uses RFSP(Reactor Fueling Simulation Program) for continuous core calculation by integrating the algorithm and assumptions validated and uses the information taken from DCC(Digital Control Computer) for the purpose of producing basic input data. CCMS could be largely divided into two modules; CCMS server program and CCMS client program. CCMS server program plays the role in automatic and continuous RFSP run and management of the past output data resulting from the run using Data Base Management System(DBMS). CCMS client program enables users to monitor current and past core status with GUI(Graphic-User Interface) environment predefined. The effectiveness of CCMS was verified by comparing the data resulted from field-test of the system for about 43 hours with the data used in the field of Wolsong NPP No. 1

Nonlinear core deflection in injection molding

Science.gov (United States)

Poungthong, P.; Giacomin, A. J.; Saengow, C.; Kolitawong, C.; Liao, H.-C.; Tseng, S.-C.

2018-05-01

Injection molding of thin slender parts is often complicated by core deflection. This deflection is caused by molten plastics race tracking through the slit between the core and the rigid cavity wall. The pressure of this liquid exerts a lateral force of the slender core causing the core to bend, and this bending is governed by a nonlinear fifth order ordinary differential equation for the deflection that is not directly in the position along the core. Here we subject this differential equation to 6 sets of boundary conditions, corresponding to 6 commercial core constraints. For each such set of boundary conditions, we develop an explicit approximate analytical solution, including both a linear term and a nonlinear term. By comparison with finite difference solutions, we find our new analytical solutions to be accurate. We then use these solutions to derive explicit analytical approximations for maximum deflections and for the core position of these maximum deflections. Our experiments on the base-gated free-tip boundary condition agree closely with our new explicit approximate analytical solution.

Development of CANDU core monitoring system

Energy Technology Data Exchange (ETDEWEB)

Yoon, M. Y.; Yeam, C. S.; Kwon, O. H.; Kim, K. H. [Institute for Advanced Engineering, Yongin (Korea, Republic of)

2003-07-01

The research was performed to develop a CANDU Core Monitoring System(CCMS) that enables operators to have efficient core management by monitoring core power distribution, burnup distribution, and the other important core variables and managing the past core history for Wolsong Nuclear Power Plant(NPP) No. 1. CCMS uses RFSP(Reactor Fueling Simulation Program) for continuous core calculation by integrating the algorithm and assumptions validated and uses the information taken from DCC(Digital Control Computer) for the purpose of producing basic input data. CCMS could be largely divided into two modules; CCMS server program and CCMS client program. CCMS server program plays the role in automatic and continuous RFSP run and management of the past output data resulting from the run using Data Base Management System(DBMS). CCMS client program enables users to monitor current and past core status with GUI(Graphic-User Interface) environment predefined. The effectiveness of CCMS was verified by comparing the data resulted from field-test of the system for about 43 hours with the data used in the field of Wolsong NPP No. 1.

Improved core protection calculator system algorithm

International Nuclear Information System (INIS)

Yoon, Tae Young; Park, Young Ho; In, Wang Kee; Bae, Jong Sik; Baeg, Seung Yeob

2009-01-01

Core Protection Calculator System (CPCS) is a digitized core protection system which provides core protection functions based on two reactor core operation parameters, Departure from Nucleate Boiling Ratio (DNBR) and Local Power Density (LPD). It generates a reactor trip signal when the core condition exceeds the DNBR or LPD design limit. It consists of four independent channels which adapted a two out of four trip logic. CPCS algorithm improvement for the newly designed core protection calculator system, RCOPS (Reactor COre Protection System), is described in this paper. New features include the improvement of DNBR algorithm for thermal margin, the addition of pre trip alarm generation for auxiliary trip function, VOPT (Variable Over Power Trip) prevention during RPCS (Reactor Power Cutback System) actuation and the improvement of CEA (Control Element Assembly) signal checking algorithm. To verify the improved CPCS algorithm, CPCS algorithm verification tests, 'Module Test' and 'Unit Test', would be performed on RCOPS single channel facility. It is expected that the improved CPCS algorithm will increase DNBR margin and enhance the plant availability by reducing unnecessary reactor trips

SCORPIO - VVER core surveillance system

International Nuclear Information System (INIS)

Zalesky, K.; Svarny, J.; Novak, L.; Rosol, J.; Horanes, A.

1997-01-01

The Halden Project has developed the core surveillance system SCORPIO which has two parallel modes of operation: the Core Follow Mode and the Predictive Mode. The main motivation behind the development of SCORPIO is to make a practical tool for reactor operators which can increase the quality and quantity of information presented on core status and dynamic behavior. This can first of all improve plant safety as undesired core conditions are detected and prevented. Secondly, more flexible and efficient plant operation is made possible. So far the system has only been implemented on western PWRs but the basic concept is applicable to a wide range of reactor including WWERs. The main differences between WWERs and typical western PWRs with respect to core surveillance requirements are outlined. The development of a WWER version of SCORPIO was initiated in cooperation with the Nuclear Research Institute at Rez and industry partners in the Czech Republic. The first system will be installed at the Dukovany NPP. (author)

The thermal evolution of Mercury's Fe-Si core

Science.gov (United States)

Knibbe, Jurriën Sebastiaan; van Westrenen, Wim

2018-01-01

We have studied the thermal and magnetic field evolution of planet Mercury with a core of Fe-Si alloy to assess whether an Fe-Si core matches its present-day partially molten state, Mercury's magnetic field strength, and the observed ancient crustal magnetization. The main advantages of an Fe-Si core, opposed to a previously assumed Fe-S core, are that a Si-bearing core is consistent with the highly reduced nature of Mercury and that no compositional convection is generated upon core solidification, in agreement with magnetic field indications of a stable layer at the top of Mercury's core. This study also present the first implementation of a conductive temperature profile in the core where heat fluxes are sub-adiabatic in a global thermal evolution model. We show that heat migrates from the deep core to the outer part of the core as soon as heat fluxes at the outer core become sub-adiabatic. As a result, the deep core cools throughout Mercury's evolution independent of the temperature evolution at the core-mantle boundary, causing an early start of inner core solidification and magnetic field generation. The conductive layer at the outer core suppresses the rate of core growth after temperature differences between the deep and shallow core are relaxed, such that a magnetic field can be generated until the present. Also, the outer core and mantle operate at higher temperatures than previously thought, which prolongs mantle melting and mantle convection. The results indicate that S is not a necessary ingredient of Mercury's core, bringing bulk compositional models of Mercury more in line with reduced meteorite analogues.

Prostate Cancer Biospecimen Cohort Study

Science.gov (United States)

2017-10-01

opinions and/or findings contained in this report are those of the author(s) and should not be construed as an official Department of the Army...SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION / AVAILABILITY STATEMENT Approved for Public Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES...14. ABSTRACT The goal of the study is development of a Prostate Cancer Biorepository Network (PCBN) resource site with high quality and well

Low void effect (CFV) core concept flexibility: from self-breeder to burner core - 15091

International Nuclear Information System (INIS)

Buiron, L.; Dujcikova, L.

2015-01-01

In the frame of the French strategy on sustainable nuclear energy, several scenarios consider fuel cycle transition toward a plutonium multi-recycling strategy in sodium cooled fast reactor (SFR). Basically, most of these scenarios consider the deployment of a 60 GWe SFR fleet in 2 steps to renew the French PWR fleet. As scenarios do investigate long term deployment configurations, some of them require tools for nuclear phase-out studies. Instead of designing new reactors, the adopted strategy does focus on adaptation of existing ones into burner configurations. This is what was done in the frame of the EFR project at the end of the 90's using the CAPRA approach (French acronym for Enhance Plutonium Consumption in Fast Reactor). The EFR burner configuration was obtained by inserting neutronic penalties inside the core (absorber material and/or diluent subassembly). Starting from the preliminary industrial image of a SFR 3600 MWth core based on Low Sodium Void concept (CFV in French), a 'CAPRA-like' approach has been studied. As the CFV self-breeding is ensured by fertile blankets, a first modification consisted in the substitution of the corresponding depleted uranium by 'inert' or absorber material leading to a 'natural burner' core with only small impacts on flux distribution. The next step forward CAPRA configuration was the substitution of 1/3 of the fuel pins by 'dummy' pins (MgO pellets). The small spectrum shift due to MgO material insertion leads to an increase Doppler constant which exceeds the value of the reference case. As the core sodium void worth value is conserved, the CFV CAPRA core 'safety' potential is quite similar to the one of the reference core. Fuel thermo-mechanical requirements are met by both nominal core power and fuel time residence reduction. However, these reduction factors are lower than those obtained for EFR core. The management of the enhanced reactivity swing is discussed

Social phobia and selective mutism.

Science.gov (United States)

Keeton, Courtney P; Crosby Budinger, Meghan

2012-07-01

Social phobia (SOP) and selective mutism (SM) are related anxiety disorders characterized by distress and dysfunction in social situations. SOP typically onsets in adolescence and affects about 8% of the general population, whereas SM onsets before age 5 and is prevalent in up to 2% of youth. Prognosis includes a chronic course that confers risk for other disorders or ongoing social disability, but more favorable outcomes may be associated with young age and low symptom severity. SOP treatments are relatively more established, whereas dissemination of promising and innovative SM-treatment strategies is needed.

Information system of taxones and biotopes of the State protection of nature of the Slovak Republic

International Nuclear Information System (INIS)

Jurecek, R.; Kuerthy, A.

2005-01-01

Information system of taxones and biotopes (ISTB) of the State protection of environment of the Slovak Republic (SOP SR) is a database system established in order to collection and processing of botanic, zoologic and biotopic data. It has arisen on the base of tasks of the SOP SR resulting from activities of species protection of animals and plants and their monitoring. It is an open system dedicated for exchange of data and for cooperation of specialist of the SOP SR, academic institutes, professional organisations and anon-professional naturalists

Core shroud corner joints

Science.gov (United States)

Gilmore, Charles B.; Forsyth, David R.

2013-09-10

A core shroud is provided, which includes a number of planar members, a number of unitary corners, and a number of subassemblies each comprising a combination of the planar members and the unitary corners. Each unitary corner comprises a unitary extrusion including a first planar portion and a second planar portion disposed perpendicularly with respect to the first planar portion. At least one of the subassemblies comprises a plurality of the unitary corners disposed side-by-side in an alternating opposing relationship. A plurality of the subassemblies can be combined to form a quarter perimeter segment of the core shroud. Four quarter perimeter segments join together to form the core shroud.

THE ENIGMATIC CORE L1451-mm: A FIRST HYDROSTATIC CORE? OR A HIDDEN VeLLO?

Energy Technology Data Exchange (ETDEWEB)

Pineda, Jaime E.; Goodman, Alyssa A.; Bourke, Tyler; Foster, Jonathan B.; Robitaille, Thomas; Kauffmann, Jens [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Arce, Hector G.; Tanner, Joel [Department of Astronomy, Yale University, P.O. Box 208101, New Haven, CT 06520-8101 (United States); Schnee, Scott [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Tafalla, Mario [Observatorio Astronomico Nacional (IGN), Alfonso XII 3, E-28014 Madrid (Spain); Caselli, Paola [School of Physics and Astronomy, University of Leeds, Leeds LS2 9JT (United Kingdom); Anglada, Guillem, E-mail: jaime.pineda@manchester.ac.uk [Instituto de Astrofisica de Andalucia, CSIC, Apartado 3004, E-18080 Granada (Spain)

2011-12-20

We present the detection of a dust continuum source at 3 mm (CARMA) and 1.3 mm (Submillimeter Array, SMA), and {sup 12}CO (2-1) emission (SMA) toward the L1451-mm dense core. These detections suggest a compact object and an outflow where no point source at mid-infrared wavelengths is detected using Spitzer. An upper limit for the dense core bolometric luminosity of 0.05 L{sub Sun} is obtained. By modeling the broadband spectral energy distribution and the continuum interferometric visibilities simultaneously, we confirm that a central source of heating is needed to explain the observations. This modeling also shows that the data can be well fitted by a dense core with a young stellar object (YSO) and a disk, or by a dense core with a central first hydrostatic core (FHSC). Unfortunately, we are not able to decide between these two models, which produce similar fits. We also detect {sup 12}CO (2-1) emission with redshifted and blueshifted emission suggesting the presence of a slow and poorly collimated outflow, in opposition to what is usually found toward YSOs but in agreement with prediction from simulations of an FHSC. This presents the best candidate, so far, for an FHSC, an object that has been identified in simulations of collapsing dense cores. Whatever the true nature of the central object in L1451-mm, this core presents an excellent laboratory to study the earliest phases of low-mass star formation.

THE ENIGMATIC CORE L1451-mm: A FIRST HYDROSTATIC CORE? OR A HIDDEN VeLLO?

International Nuclear Information System (INIS)

Pineda, Jaime E.; Goodman, Alyssa A.; Bourke, Tyler; Foster, Jonathan B.; Robitaille, Thomas; Kauffmann, Jens; Arce, Héctor G.; Tanner, Joel; Schnee, Scott; Tafalla, Mario; Caselli, Paola; Anglada, Guillem

2011-01-01

We present the detection of a dust continuum source at 3 mm (CARMA) and 1.3 mm (Submillimeter Array, SMA), and 12 CO (2-1) emission (SMA) toward the L1451-mm dense core. These detections suggest a compact object and an outflow where no point source at mid-infrared wavelengths is detected using Spitzer. An upper limit for the dense core bolometric luminosity of 0.05 L ☉ is obtained. By modeling the broadband spectral energy distribution and the continuum interferometric visibilities simultaneously, we confirm that a central source of heating is needed to explain the observations. This modeling also shows that the data can be well fitted by a dense core with a young stellar object (YSO) and a disk, or by a dense core with a central first hydrostatic core (FHSC). Unfortunately, we are not able to decide between these two models, which produce similar fits. We also detect 12 CO (2-1) emission with redshifted and blueshifted emission suggesting the presence of a slow and poorly collimated outflow, in opposition to what is usually found toward YSOs but in agreement with prediction from simulations of an FHSC. This presents the best candidate, so far, for an FHSC, an object that has been identified in simulations of collapsing dense cores. Whatever the true nature of the central object in L1451-mm, this core presents an excellent laboratory to study the earliest phases of low-mass star formation.

PWR core design calculations

International Nuclear Information System (INIS)

Trkov, A.; Ravnik, M.; Zeleznik, N.

1992-01-01

Functional description of the programme package Cord-2 for PWR core design calculations is presented. Programme package is briefly described. Use of the package and calculational procedures for typical core design problems are treated. Comparison of main results with experimental values is presented as part of the verification process. (author) [sl

Influence of core sand properties on flow dynamics of core shooting process based on experiment and multiphase simulation

Directory of Open Access Journals (Sweden)

Chang-jiang Ni

2017-03-01

Full Text Available The influence of core sand properties on flow dynamics was investigated synchronously with various core sands, transparent core-box and high-speed camera. To confirm whether the core shooting process has significant turbulence, the flow pattern of sand particles in the shooting head and core box was reproduced with colored core sands. By incorporating the kinetic theory of granular flow (KTGF, kinetic-frictional constitutive correlation and turbulence model, a two-fluid model (TFM was established to study the flow dynamics of the core shooting process. Two-fluid model (TFM simulations were then performed and a areasonable agreement was achieved between the simulation and experimental results. Based on the experimental and simulation results, the effects of turbulence, sand density, sand diameter and binder ratio were analyzed in terms of filling process, sand volume fraction (αs and sand velocity (Vs.

Reactor core performance calculating device

International Nuclear Information System (INIS)

Tominaga, Kenji; Bando, Masaru; Sano, Hiroki; Maruyama, Hiromi.

1995-01-01

The device of the present invention can calculate a power distribution efficiently at high speed by a plurality of calculation means while taking an amount of the reactor state into consideration. Namely, an input device takes data from a measuring device for the amount of the reactor core state such as a large number of neutron detectors disposed in the reactor core for monitoring the reactor state during operation. An input data distribution device comprises a state recognition section and a data distribution section. The state recognition section recognizes the kind and amount of the inputted data and information of the calculation means. The data distribution section analyzes the characteristic of the inputted data, divides them into a several groups, allocates them to each of the calculation means for the purpose of calculating the reactor core performance efficiently at high speed based on the information from the state recognition section. A plurality of the calculation means calculate power distribution of each of regions based on the allocated inputted data, to determine the power distribution of the entire reactor core. As a result, the reactor core can be evaluated at high accuracy and at high speed irrespective of the whole reactor core or partial region. (I.S.)

Core cooling system for reactor

International Nuclear Information System (INIS)

Kondo, Ryoichi; Amada, Tatsuo.

1976-01-01

Purpose: To improve the function of residual heat dissipation from the reactor core in case of emergency by providing a secondary cooling system flow channel, through which fluid having been subjected to heat exchange with the fluid flowing in a primary cooling system flow channel flows, with a core residual heat removal system in parallel with a main cooling system provided with a steam generator. Constitution: Heat generated in the core during normal reactor operation is transferred from a primary cooling system flow channel to a secondary cooling system flow channel through a main heat exchanger and then transferred through a steam generator to a water-steam system flow channel. In the event if removal of heat from the core by the main cooling system becomes impossible due to such cause as breakage of the duct line of the primary cooling system flow channel or a trouble in a primary cooling system pump, a flow control valve is opened, and steam generator inlet and outlet valves are closed, thus increasing the flow rate in the core residual heat removal system. Thereafter, a blower is started to cause dissipation of the core residual heat from the flow channel of a system for heat dissipation to atmosphere. (Seki, T.)

Iron snow in the Martian core?

Science.gov (United States)

Davies, Christopher J.; Pommier, Anne

2018-01-01

The decline of Mars' global magnetic field some 3.8-4.1 billion years ago is thought to reflect the demise of the dynamo that operated in its liquid core. The dynamo was probably powered by planetary cooling and so its termination is intimately tied to the thermochemical evolution and present-day physical state of the Martian core. Bottom-up growth of a solid inner core, the crystallization regime for Earth's core, has been found to produce a long-lived dynamo leading to the suggestion that the Martian core remains entirely liquid to this day. Motivated by the experimentally-determined increase in the Fe-S liquidus temperature with decreasing pressure at Martian core conditions, we investigate whether Mars' core could crystallize from the top down. We focus on the "iron snow" regime, where newly-formed solid consists of pure Fe and is therefore heavier than the liquid. We derive global energy and entropy equations that describe the long-timescale thermal and magnetic history of the core from a general theory for two-phase, two-component liquid mixtures, assuming that the snow zone is in phase equilibrium and that all solid falls out of the layer and remelts at each timestep. Formation of snow zones occurs for a wide range of interior and thermal properties and depends critically on the initial sulfur concentration, ξ0. Release of gravitational energy and latent heat during growth of the snow zone do not generate sufficient entropy to restart the dynamo unless the snow zone occupies at least 400 km of the core. Snow zones can be 1.5-2 Gyrs old, though thermal stratification of the uppermost core, not included in our model, likely delays onset. Models that match the available magnetic and geodetic constraints have ξ0 ≈ 10% and snow zones that occupy approximately the top 100 km of the present-day Martian core.

Bulimia nerviosa

Science.gov (United States)

... SOP) Infecciones de transmisión sexual (ITS) Fibromas uterinos Candidiasis vaginal Todos los temas de salud de la A ... SOP) Infecciones de transmisión sexual (ITS) Fibromas uterinos Candidiasis vaginal Todos los temas de salud de la A ...

NHEXAS PHASE I ARIZONA STUDY--STANDARD OPERATING PROCEDURE FOR COLLECTION, STORAGE AND SHIPMENT OF URINE SAMPLES FOR SELECTED METALS AND PESTICIDES (UA-F-20.1)

Science.gov (United States)

The purpose of this SOP is to guide the collection, storage, and shipment of urine samples collected for the NHEXAS Arizona project. This SOP provides a brief description of sample, collection, preservation, storage, shipping, and custody procedures. This procedure was followed ...

U.S.-MEXICO BORDER PROGRAM ARIZONA BORDER STUDY--STANDARD OPERATING PROCEDURE FOR COLLECTION, STORAGE, AND SHIPMENT OF URINE SAMPLES FOR METALS AND PESTICIDES ANALYSIS (UA-F-20.1)

Science.gov (United States)

The purpose of this SOP is to guide the collection, storage, and shipment of urine samples collected. This SOP provides a brief description of sample, collection, preservation, storage, shipping, and custody procedures. This procedure was followed to ensure consistent data retri...

Core trénink ve florbale

OpenAIRE

Mašková, Alžběta

2014-01-01

Title: Use of core training in floorball Objectives: Present an overview of research papers regarding core training and its possible use in floorball Tasks: First aim of this thesis is to provide description and explanation of the core training by using available literature, research papers, bachelor or magister thesis and also thesis of the coaching school. Second aim is to analyze the necessary components of floorball player's performance relative to the core training. This is followed by a...

Investigating the translation of Earth's inner core

DEFF Research Database (Denmark)

Day, Elizabeth A; Cormier, Vernon F; Geballe, Zachary M

2012-01-01

The Earth’s inner core provides unique insights into processes that are occurring deep within our Earth today, as well as processes that occurred in the past. The seismic structure of the inner core is complex, and is dominated by anisotropic and isotropic differences between the Eastern...... for models of a translating inner core. Additionally, we investigate the structure at the base of the outer core and the inner core boundary by analyzing PKP-Cdiff waves. The search for observable PKP-Cdiff is particularly concentrated in regions that are predicted to be actively freezing and melting...... and Western ‘hemispheres’ of the inner core. Recent geodynamical models suggest that this hemispherical dichotomy can be explained by a fast translation of the inner core. In these models one side of the inner core is freezing, while the other side is melting, leading to the development of different seismic...

Feasibility Study of Core Design with a Monte Carlo Code for APR1400 Initial core

Energy Technology Data Exchange (ETDEWEB)

Kim, Jinsun; Chang, Do Ik; Seong, Kibong [KEPCO NF, Daejeon (Korea, Republic of)

2014-10-15

The Monte Carlo calculation becomes more popular and useful nowadays due to the rapid progress in computing power and parallel calculation techniques. There have been many attempts to analyze a commercial core by Monte Carlo transport code using the enhanced computer capability, recently. In this paper, Monte Carlo calculation of APR1400 initial core has been performed and the results are compared with the calculation results of conventional deterministic code to find out the feasibility of core design using Monte Carlo code. SERPENT, a 3D continuous-energy Monte Carlo reactor physics burnup calculation code is used for this purpose and the KARMA-ASTRA code system, which is used for a deterministic code of comparison. The preliminary investigation for the feasibility of commercial core design with Monte Carlo code was performed in this study. Simplified core geometry modeling was performed for the reactor core surroundings and reactor coolant model is based on two region model. The reactivity difference at HZP ARO condition between Monte Carlo code and the deterministic code is consistent with each other and the reactivity difference during the depletion could be reduced by adopting the realistic moderator temperature. The reactivity difference calculated at HFP, BOC, ARO equilibrium condition was 180 ±9 pcm, with axial moderator temperature of a deterministic code. The computing time will be a significant burden at this time for the application of Monte Carlo code to the commercial core design even with the application of parallel computing because numerous core simulations are required for actual loading pattern search. One of the remedy will be a combination of Monte Carlo code and the deterministic code to generate the physics data. The comparison of physics parameters with sophisticated moderator temperature modeling and depletion will be performed for a further study.

Calculation of ex-core detector responses

Energy Technology Data Exchange (ETDEWEB)

Wouters, R. de; Haedens, M. [Tractebel Engineering, Brussels (Belgium); Baenst, H. de [Electrabel, Brussels (Belgium)

2005-07-01

The purpose of this work carried out by Tractebel Engineering, is to develop and validate a method for predicting the ex-core detector responses in the NPPs operated by Electrabel. Practical applications are: prediction of ex-core calibration coefficients for startup power ascension, replacement of xenon transients by theoretical predictions, and analysis of a Rod Drop Accident. The neutron diffusion program PANTHER calculates node-integrated fission sources which are combined with nodal importance representing the contribution of a neutron born in that node to the ex-core response. These importance are computed with the Monte Carlo program MCBEND in adjoint mode, with a model of the whole core at full power. Other core conditions are treated using sensitivities of the ex-core responses to water densities, computed with forward Monte Carlo. The Scaling Factors (SF), or ratios of the measured currents to the calculated response, have been established on a total of 550 in-core flux maps taken in four NPPs. The method has been applied to 15 startup transients, using the average SF obtained from previous cycles, and to 28 xenon transients, using the SF obtained from the in-core map immediately preceding the transient. The values of power (P) and axial offset (AOi) reconstructed with the theoretical calibration agree well with the measured values. The ex-core responses calculated during a rod drop transient have been successfully compared with available measurements, and with theoretical data obtained by alternative methods. In conclusion, the method is adequate for the practical applications previously listed. (authors)

GREEN CORE HOUSE

Directory of Open Access Journals (Sweden)

NECULAI Oana

2017-05-01

Full Text Available The Green Core House is a construction concept with low environmental impact, having as main central element a greenhouse. The greenhouse has the innovative role to use the biomass energy provided by plants to save energy. Although it is the central piece, the greenhouse is not the most innovative part of the Green Core House, but the whole building ensemble because it integrates many other sustainable systems as "waste purification systems", "transparent photovoltaic panels" or "double skin façades".

HCV Core Residues Critical for Infectivity Are Also Involved in Core-NS5A Complex Formation

Science.gov (United States)

Gawlik, Katarzyna; Baugh, James; Chatterji, Udayan; Lim, Precious J.; Bobardt, Michael D.; Gallay, Philippe A.

2014-01-01

Hepatitis C virus (HCV) infection is a major cause of liver disease. The molecular machinery of HCV assembly and particle release remains obscure. A better understanding of the assembly events might reveal new potential antiviral strategies. It was suggested that the nonstructural protein 5A (NS5A), an attractive recent drug target, participates in the production of infectious particles as a result of its interaction with the HCV core protein. However, prior to the present study, the NS5A-binding site in the viral core remained unknown. We found that the D1 domain of core contains the NS5A-binding site with the strongest interacting capacity in the basic P38-K74 cluster. We also demonstrated that the N-terminal basic residues of core at positions 50, 51, 59 and 62 were required for NS5A binding. Analysis of all substitution combinations of R50A, K51A, R59A, and R62A, in the context of the HCVcc system, showed that single, double, triple, and quadruple mutants were fully competent for viral RNA replication, but deficient in secretion of viral particles. Furthermore, we found that the extracellular and intracellular infectivity of all the mutants was abolished, suggesting a defect in the formation of infectious particles. Importantly, we showed that the interaction between the single and quadruple core mutants and NS5A was impaired in cells expressing full-length HCV genome. Interestingly, mutations of the four basic residues of core did not alter the association of core or NS5A with lipid droplets. This study showed for the first time that basic residues in the D1 domain of core that are critical for the formation of infectious extracellular and intracellular particles also play a role in core-NS5A interactions. PMID:24533158

Neutronic characteristics of FLWR in the transition phase changing from high conversion core to breeder core

International Nuclear Information System (INIS)

Akie, Hiroshi; Nakano, Yoshihiro; Okubo, Tsutomu

2009-01-01

Innovative Water Reactor for Flexible Fuel Cycle (FLWR) is a low moderation type boiling water reactor which can realize plutonium multiple recycling and breeding. For the introduction stage of FLWR, a high conversion (HC) type FLWR is proposed to keep technical continuity from current light water reactors. The HC core of FLWR has a less tight fuel lattice with lower coolant void fraction than the breeder (BR) type core. The HC type FLWR core is to be shifted to the BR core by only replacing the fuel assemblies of the same outer shape and size in the same reactor system. In the HC to BR transition phase of FLWR, there exist both types of fuel assemblies in the same core configuration. In the HC assembly, neutron spectrum is softer than in the BR assembly, and the axial fuel and blanket arrangement is different from the BR assembly. Due to these differences, there might appear a power peaking in the adjacent region between HC and BR assemblies. The power distribution in the HC + BR assemblies mixed core configuration is studied by performing assembly calculations and core calculations on a few assemblies local geometry and the whole core geometry. As a result, although a power peaking can be locally very large in the HC and BR assemblies adjacent regions, such local power peakings are shown to be effectively reduced by considering a rod-wise fuel enrichment distribution. In the whole core calculation, it seems possible to optimize the fuel assembly loading and shuffling pattern to avoid large power level mismatch between the assemblies. It is expected that FLWR can be shifted from HC type to BR type without major neutronic difficulties. (author)

Magnetic nuclear core restraint and control

International Nuclear Information System (INIS)

Cooper, M.H.

1979-01-01

A lateral restraint and control system for a nuclear reactor core adaptable to provide an inherent decrease of core reactivity in response to abnormally high reactor coolant fluid temperatures. An electromagnet is associated with structure for radially compressing the core during normal reactor conditions. A portion of the structures forming a magnetic circuit are composed of ferromagnetic material having a curie temperature corresponding to a selected coolant fluid temperature. Upon a selected signal, or inherently upon a preselected rise in coolant temperature, the magnetic force is decreased a given amount sufficient to relieve the compression force so as to allow core radial expansion. The expanded core configuration provides a decreased reactivity, tending to shut down the nuclear reaction

Magnetic nuclear core restraint and control

International Nuclear Information System (INIS)

Cooper, M.H.

1979-01-01

A lateral restraint and control systemm for a nuclear reactor core provides an inherent decrease of core reactivity in response to abnormally high reactor coolant fluid temperatures. An electromagnet is associated with structure for radially compressing the core during normal reactor conditions. A portion of the structures forming a magnetic circuit is composed of ferromagnetic material having a curie temperature corresponding to a selected coolant fluid temperature. Upon a selected signal, or inherently upon a preselected rise in coolant temperature, the magnetic force is decreased by an amount sufficient to relieve the compression force so as to allow core radial expansion. The expanded core configuration provides a decreased reactivity, tending to shut down the nuclear reaction

Updated procedures for using drill cores and cuttings at the Lithologic Core Storage Library, Idaho National Laboratory, Idaho

Science.gov (United States)

Hodges, Mary K.V.; Davis, Linda C.; Bartholomay, Roy C.

2018-01-30

In 1990, the U.S. Geological Survey, in cooperation with the U.S. Department of Energy Idaho Operations Office, established the Lithologic Core Storage Library at the Idaho National Laboratory (INL). The facility was established to consolidate, catalog, and permanently store nonradioactive drill cores and cuttings from subsurface investigations conducted at the INL, and to provide a location for researchers to examine, sample, and test these materials.The facility is open by appointment to researchers for examination, sampling, and testing of cores and cuttings. This report describes the facility and cores and cuttings stored at the facility. Descriptions of cores and cuttings include the corehole names, corehole locations, and depth intervals available.Most cores and cuttings stored at the facility were drilled at or near the INL, on the eastern Snake River Plain; however, two cores drilled on the western Snake River Plain are stored for comparative studies. Basalt, rhyolite, sedimentary interbeds, and surficial sediments compose most cores and cuttings, most of which are continuous from land surface to their total depth. The deepest continuously drilled core stored at the facility was drilled to 5,000 feet below land surface. This report describes procedures and researchers' responsibilities for access to the facility and for examination, sampling, and return of materials.

Can Psychiatric Rehabilitation Be Core to CORE?

Science.gov (United States)

Olney, Marjorie F.; Gill, Kenneth J.

2016-01-01

Purpose: In this article, we seek to determine whether psychiatric rehabilitation principles and practices have been more fully incorporated into the Council on Rehabilitation Education (CORE) standards, the extent to which they are covered in four rehabilitation counseling "foundations" textbooks, and how they are reflected in the…

Core labeling of adenovirus with EGFP

International Nuclear Information System (INIS)

Le, Long P.; Le, Helen N.; Nelson, Amy R.; Matthews, David A.; Yamamoto, Masato; Curiel, David T.

2006-01-01

The study of adenovirus could greatly benefit from diverse methods of virus detection. Recently, it has been demonstrated that carboxy-terminal EGFP fusions of adenovirus core proteins Mu, V, and VII properly localize to the nucleus and display novel function in the cell. Based on these observations, we hypothesized that the core proteins may serve as targets for labeling the adenovirus core with fluorescent proteins. To this end, we constructed various chimeric expression vectors with fusion core genes (Mu-EGFP, V-EGFP, preVII-EGFP, and matVII-EGFP) while maintaining expression of the native proteins. Expression of the fusion core proteins was suboptimal using E1 expression vectors with both conventional CMV and modified (with adenovirus tripartite leader sequence) CMV5 promoters, resulting in non-labeled viral particles. However, robust expression equivalent to the native protein was observed when the fusion genes were placed in the deleted E3 region. The efficient Ad-wt-E3-V-EGFP and Ad-wt-E3-preVII-EGFP expression vectors were labeled allowing visualization of purified virus and tracking of the viral core during early infection. The vectors maintained their viral function, including viral DNA replication, viral DNA encapsidation, cytopathic effect, and thermostability. Core labeling offers a means to track the adenovirus core in vector targeting studies as well as basic adenovirus virology

JOYO MK-II core characteristics database

International Nuclear Information System (INIS)

Ohkawachi, Yasushi; Maeda, Shigetaka; Sekine, Takashi; Aoyama, Takafumi

2003-04-01

The 'JOYO' MK-II core characteristics database was compiled and published in 1998. Comments and requests from many users led to the creation of a revised edition. The revisions include changes to the MAGI calculation code system to use the 70 group JFS-3-J3.2 constant set processed from the JENDL-3.2 library. Total control rod worth, reactor kinetic parameters and the MK-II core performance test results were included per user's requests. The core characteristics obtained from the 32 nd to 35 th operational cycles, which were conducted in the MK-III transition core, were newly added in this revised version. The MK-II core management data and core characteristics data were recorded to CD-ROM for user convenience. The Configuration Data' include the core arrangement and refueling record for each operational cycle. The 'Subassembly Library Data' include the atomic number density, neutron fluence, burn-up, integral power of 362 driver fuel subassemblies and 69 irradiation test subassemblies. The 'Output Data' contain the calculated neutron flux, gamma flux, power density, linear heat rate, coolant and fuel temperature distribution of all the fuel subassemblies at the beginning and end of each operational cycle. The 'Core Characteristics Data' include the measured excess reactivity, control rod worth calibration curve, and reactivity coefficients of temperature, power and burn-up. (author)

The Fuzziness of Giant Planets’ Cores

Energy Technology Data Exchange (ETDEWEB)

Helled, Ravit [Institute for Computational Science, University of Zurich, Zurich (Switzerland); Stevenson, David [Division of Geological and Planetary Sciences, Caltech, Pasadena, CA (United States)

2017-05-01

Giant planets are thought to have cores in their deep interiors, and the division into a heavy-element core and hydrogen–helium envelope is applied in both formation and structure models. We show that the primordial internal structure depends on the planetary growth rate, in particular, the ratio of heavy elements accretion to gas accretion. For a wide range of likely conditions, this ratio is in one-to-one correspondence with the resulting post-accretion profile of heavy elements within the planet. This flux ratio depends sensitively on the assumed solid-surface density in the surrounding nebula. We suggest that giant planets’ cores might not be distinct from the envelope and includes some hydrogen and helium, and the deep interior can have a gradual heavy-element structure. Accordingly, Jupiter’s core may not be well defined. Accurate measurements of Jupiter’s gravitational field by Juno could put constraints on Jupiter’s core mass. However, as we suggest here, the definition of Jupiter’s core is complex, and the core’s physical properties (mass, density) depend on the actual definition of the core and on the planet’s growth history.

The Fuzziness of Giant Planets’ Cores

International Nuclear Information System (INIS)

Helled, Ravit; Stevenson, David

2017-01-01

Giant planets are thought to have cores in their deep interiors, and the division into a heavy-element core and hydrogen–helium envelope is applied in both formation and structure models. We show that the primordial internal structure depends on the planetary growth rate, in particular, the ratio of heavy elements accretion to gas accretion. For a wide range of likely conditions, this ratio is in one-to-one correspondence with the resulting post-accretion profile of heavy elements within the planet. This flux ratio depends sensitively on the assumed solid-surface density in the surrounding nebula. We suggest that giant planets’ cores might not be distinct from the envelope and includes some hydrogen and helium, and the deep interior can have a gradual heavy-element structure. Accordingly, Jupiter’s core may not be well defined. Accurate measurements of Jupiter’s gravitational field by Juno could put constraints on Jupiter’s core mass. However, as we suggest here, the definition of Jupiter’s core is complex, and the core’s physical properties (mass, density) depend on the actual definition of the core and on the planet’s growth history.

DNA compaction by poly (amido amine) dendrimers of ammonia cored and ethylene diamine cored

Science.gov (United States)

Qamhieh, K.; Al-Shawwa, J.

2017-06-01

The complexes build-up of DNA and soft particles poly amidoamine (PAMAM) dendrimers of ammonia cored of generations (G1-G6) and ethylenediamine cored of generations (G1-G10) have been studied, using a new theoretical model developed by Qamhieh and coworkers. The model describes the interaction between linear polyelectrolyte (LPE) chain and ion-penetrable spheres. Many factors affecting LPE/dendrimer complex have been investigated such as dendrimer generation, the Bjerrum length, salt concentration, and rigidity of the LPE chain represented by the persistence length. It is found that the wrapping chain length around dendrimer increases by increasing dendrimer`s generation, Bjerrum length, and salt concentration, while decreases by increasing the persistence length of the LPE chain. Also we can conclude that the wrapping length of LPE chain around ethylenediamine cored dendrimers is larger than its length around ammonia cored dendrimers.

Family and infant characteristics associated with timing of core and non-core food introduction in early childhood

OpenAIRE

Schrempft, Stephanie; van Jaarsveld, Cornelia H.M.; Fisher, Abigail; Wardle, Jane

2013-01-01

Objective To identify family and infant characteristics associated with timing of introduction of two food types: core foods (nutrient-dense) and non-core foods (nutrient-poor) in a population-based sample of mothers and infants. Method Participants were 1861 mothers and infants from the Gemini twin birth cohort (one child per family). Family and infant characteristics were assessed when the infants were around 8 months old. Timing of introducing core and non-core foods was assessed at 8 and ...

A HYBRID GENETIC ALGORITHM-NEURAL NETWORK APPROACH FOR PRICING CORES AND REMANUFACTURED CORES

Directory of Open Access Journals (Sweden)

M. Seidi

2012-01-01

Full Text Available

ENGLISH ABSTRACT:Sustainability has become a major issue in most economies, causing many leading companies to focus on product recovery and reverse logistics. Remanufacturing is an industrial process that makes used products reusable. One of the important aspects in both reverse logistics and remanufacturing is the pricing of returned and remanufactured products (called cores. In this paper, we focus on pricing the cores and remanufactured cores. First we present a mathematical model for this purpose. Since this model does not satisfy our requirements, we propose a simulation optimisation approach. This approach consists of a hybrid genetic algorithm based on a neural network employed as the fitness function. We use automata learning theory to obtain the learning rate required for training the neural network. Numerical results demonstrate that the optimal value of the acquisition price of cores and price of remanufactured cores is obtained by this approach.

AFRIKAANSE OPSOMMING: Volhoubaarheid het ‘n belangrike saak geword in die meeste ekonomieë, wat verskeie maatskappye genoop het om produkherwinning en omgekeerde logistiek te onder oë te neem. Hervervaardiging is ‘n industriële proses wat gebruikte produkte weer bruikbaar maak. Een van die belangrike aspekte in beide omgekeerde logistiek en hervervaardiging is die prysbepaling van herwinne en hervervaardigde produkte. Hierdie artikel fokus op die prysbepalingsaspekte by wyse van ‘n wiskundige model.

Drilling history core hole DC-6 Hanford, Washington

International Nuclear Information System (INIS)

1978-06-01

Core hole DC-6 was completed in May 1978 by Boyles Brothers Drilling Company, Spokane, Washington, under subcontract to Fenix and Scisson, Inc. The hole was cored for the US Department of Energy and the Rockwell Hanford Operations' Basalt Waste Isolation Program. Fenix and Scisson, Inc. furnished the engineering, daily supervision of the core drilling activities, and geologic core logging for hole DC-6. Core hole DC-6 is located within the boundary of the Hanford Site at the old Hanford town site. The Hanford Site coordinates for DC-6 are North 54,127.17 feet and West 17,721.00 feet. The surface elevation is approximately 402 feet above sea level. The purpose of core hole DC-6 was to core drill vertically through the basalt and interbed units for stratigraphic depth determination and core collection and to provide a borehole for hydrologic testing. The total depth of core hole DC-6 was 4336 feet. Core recovery was 98.4% of the total footage cored

Core damage risk indicators

International Nuclear Information System (INIS)

Szikszai, T.

1994-01-01

The purpose of this document is to show a method for the fast recalculation of the PSA. To avoid the information loose, it is necessary to simplify the PSA models, or at least reorganize them. The method, introduced in this document, require that preparation, so we try to show, how to do that. This document is an introduction. This is the starting point of the work related to the development of the risk indicators. In the future, with the application of this method, we are going to show an everyday use of the PSA results to produce the indicators of the core damage risk. There are two different indicators of the plant safety performance, related to the core damage risk. The first is the core damage frequency indicator (CDFI), and the second is the core damage probability indicator (CDPI). Of course, we cannot describe all of the possible ways to use these indicators, rather we will try to introduce the requirements to establish such an indicator system and the calculation process

Overview of core disruptive accidents

International Nuclear Information System (INIS)

Marchaterre, J.F.

1977-01-01

An overview of the analysis of core-disruptive accidents is given. These analyses are for the purpose of understanding and predicting fast reactor behavior in severe low probability accident conditions, to establish the consequences of such conditions and to provide a basis for evaluating consequence limiting design features. The methods are used to analyze core-disruptive accidents from initiating event to complete core disruption, the effects of the accident on reactor structures and the resulting radiological consequences are described

Installation of JMTR core management system

International Nuclear Information System (INIS)

Imaizumi, Tomomi; Ide, Hiroshi; Naka, Michihiro; Komukai, Bunsaku; Nagao, Yoshiharu

2013-01-01

In order to carry out the core management after the reoperation of JMTR quickly and accurately, the authors took up the Standard Reactor Analysis Code (SRAC) system and core management support programs that are operating in a general-purpose large computer and transferred them to PC (OS: Linux), and newly established a JMTR core management system. As for the core analysis, this measure enabled an increase in the processing speed from the check of core arrangement to the result display of nuclear restriction values to about 60 times, compared with the conventional method. It was confirmed that the differences of calculation results originated from the difference of internal display of computers, associated with the transfer of each analysis code from GS21-400 system to PC-Linux, were within practically allowable level. In the future, this system will be applied to the core analysis of JMTR, as well as to the preparation of operation plans. (A.O.)

The PWR cores management

International Nuclear Information System (INIS)

Barral, J.C.; Rippert, D.; Johner, J.

2000-01-01

During the meeting of the 25 january 2000, organized by the SFEN, scientists and plant operators in the domain of the PWR debated on the PWR cores management. The five first papers propose general and economic information on the PWR and also the fast neutron reactors chains in the electric power market: statistics on the electric power industry, nuclear plant unit management, the ITER project and the future of the thermonuclear fusion, the treasurer's and chairman's reports. A second part offers more technical papers concerning the PWR cores management: performance and optimization, in service load planning, the cores management in the other countries, impacts on the research and development programs. (A.L.B.)

Core radial power profile effect on system and core cooling behavior during reflood phase of PWR-LOCA with CCTF data

International Nuclear Information System (INIS)

Akimoto, Hajime; Iguchi, Tadashi; Murao, Yoshio

1985-01-01

In the reactor safety assessment during reflood phase of a PWR-LOCA, it is assumed implicitly that the core thermal hydraulic behavior is evaluated by the one-dimensional model with an average power rod. In order to assess the applicability of the one-dimensional treatment, integral tests were performed with various core radial power profiles using the Cylindrical Core Test Facility (CCTF) whose core includes about 2,000 heater rods. The CCTF results confirm that the core radial power profile has weak effect on the thermal hydraulic behavior in the primary system except core. It is also confirmed that the core differential pressure in the axial direction is predicted by the one-dimensional core model with an average power rod even in the case with a steep radial power profile in the core. Even though the core heat transfer coefficient is dependent on the core radial power profile, it is found that the error of the peak clad surface temperature calculation is less than 15 K using the one-dimensional model in the CCTF tests. The CCTF results support the one-dimensional treatment assumed in the reactor safety assessment. (author)

Double-diffusive translation of Earth's inner core

Science.gov (United States)

Deguen, R.; Alboussiére, T.; Labrosse, S.

2018-03-01

The hemispherical asymmetry of the inner core has been interpreted as resulting form a high-viscosity mode of inner core convection, consisting in a translation of the inner core. A thermally driven translation, as originally proposed, is unlikely if the currently favoured high values of the thermal conductivity of iron at core conditions are correct. We consider here the possibility that inner core translation results from an unstable compositional gradient, which would develop either because the light elements present in the core become increasingly incompatible as the inner core grows, or because of a possibly positive feedback of the development of the F-layer on inner core convection. Though the magnitude of the destabilising effect of the compositional field is predicted to be similar to or smaller than the stabilising effect of the thermal field, the huge difference between thermal and chemical diffusivities implies that double-diffusive instabilities can still arise even if the net buoyancy increases upward. Using linear stability analysis and numerical simulations, we demonstrate that a translation mode can indeed exist if the compositional field is destabilising, even if the temperature profile is subadiabatic, and irrespectively of the relative magnitudes of the composition and potential temperature gradients. The existence of this double diffusive mode of translation requires that the following conditions are met: (i) the compositional profile within the inner core is destabilising, and remains so for a duration longer than the destabilisation timescale (on the order of 200 My, but strongly dependent on the magnitude of the initial perturbation); and (ii) the inner core viscosity is sufficiently large, the required value being a strongly increasing function of the inner core size (e.g. 1017 Pa.s when the inner core was 200 km in radius, and ≃ 3 × 1021 Pa.s at the current inner core size). If these conditions are met, the predicted inner core

SCORPIO - WWER core surveillance system

International Nuclear Information System (INIS)

Hornaes, Arne; Bodal, Terje; Sunde, Svein; Zalesky, K.; Lehman, M.; Pecka, M.; Svarny, J.; Krysl, V.; Juzova, Z.; Sedlak, A.; Semmler, M.

1998-01-01

The Institut for energiteknikk has developed the core surveillance system SCORPIO, which has two parallel modes of operation: the Core Follow Mode and the Predictive Mode. The main motivation behind the development of SCORPIO is to make a practical tool for reactor operators which can increase the quality and quantity of information presented on core status and dynamic behavior. This can first of all improve plant safety, as undesired core conditions are detected and prevented. Secondly, more flexible and efficient plant operation is made possible. The system has been implemented on western PWRs, but the basic concept is applicable to a wide range of reactors including WWERs. The main differences between WWERs and typical western PWRs with respect to core surveillance requirements are outlined. The development of a WWER version of SCORPIO has been done in co-operation with the Nuclear Research Institute Rez, and industry partners in the Czech Republic. The first system is installed at Dukovany NPP, where the Site Acceptance Test was completed 6. March 1998.(Authors)

SCORPIO - VVER core surveillance system

International Nuclear Information System (INIS)

Hornaes, A.; Bodal, T.; Sunde, S.

1998-01-01

The Institutt for energiteknikk has developed the core surveillance system SCORPIO, which has two parallel modes of operation: the Core Follow Mode and the Predictive Mode. The main motivation behind the development of SCORPIO is to make a practical tool for reactor operators, which can increase the quality and quantity of information presented on core status and dynamic behavior. This can first of all improve plant safety, as undesired core conditions are detected and prevented. Secondly, more flexible and efficient plant operation is made possible. The system has been implemented on western PWRs, but the basic concept is applicable to a wide range of reactors including VVERs. The main differences between VVERs and typical western PWRs with respect to core surveillance requirements are outlined. The development of a VVER version of SCORPIO has been done in co-operation with the Nuclear Research Institute Rez, and industry partners in the Czech Republic. The first system is installed at Dukovany NPP, where the Site Acceptance Test was completed 6. March 1998.(author)

Nuclear core catchers

International Nuclear Information System (INIS)

Golden, M.P.; Tilbrook, R.W.; Heylmun, N.F.

1976-01-01

A receptacle is described for taking the molten fragments of a nuclear reactor during a reactor core fusion accident. The receptacle is placed under the reactor. It includes at least one receptacle for the reactor core fragments, with a dome shaped part to distribute the molten fragments and at least one outside layer of alumina bricks around the dome. The characteristic of this receptacle is that the outer layer of bricks contains neutron poison rods which pass through the bricks and protrude in relation to them [fr

Core rotational dynamics and geological events

Science.gov (United States)

Greff-Lefftz; Legros

1999-11-26

A study of Earth's fluid core oscillations induced by lunar-solar tidal forces, together with tidal secular deceleration of Earth's axial rotation, shows that the rotational eigenfrequency of the fluid core and some solar tidal waves were in resonance around 3.0 x 10(9), 1.8 x 10(9), and 3 x 10(8) years ago. The associated viscomagnetic frictional power at the core boundaries may be converted into heat and would destabilize the D" thermal layer, leading to the generation of deep-mantle plumes, and would also increase the temperature at the fluid core boundaries, perturbing the core dynamo process. Such phenomena could account for large-scale episodes of continental crust formation, the generation of flood basalts, and abrupt changes in geomagnetic reversal frequency.

Magnetic nuclear core restraint and control

International Nuclear Information System (INIS)

Cooper, M.H.

1978-01-01

Disclosed is a lateral restraint and control system for a nuclear reactor core adaptable to provide an inherent decrease of core reactivity in response to abnormally high reactor coolant fluid temperatures. An electromagnet is associated with structure for radially compressing the core during normal reactor conditions. A portion of the structures forming a magnetic circuit are composed of ferromagnetic material having a curie temperature corresponding to a selected coolant fluid temperature. Upon a selected signal, or inherently upon a preselected rise in coolant temperature, the magnetic force is decreased a given amount sufficient to relieve the compression force so as to allow core radial expansion. The expanded core configuration provides a decreased reactivity, tending to shut down the nuclear reaction

Multi-core processing and scheduling performance in CMS

International Nuclear Information System (INIS)

Hernández, J M; Evans, D; Foulkes, S

2012-01-01

Commodity hardware is going many-core. We might soon not be able to satisfy the job memory needs per core in the current single-core processing model in High Energy Physics. In addition, an ever increasing number of independent and incoherent jobs running on the same physical hardware not sharing resources might significantly affect processing performance. It will be essential to effectively utilize the multi-core architecture. CMS has incorporated support for multi-core processing in the event processing framework and the workload management system. Multi-core processing jobs share common data in memory, such us the code libraries, detector geometry and conditions data, resulting in a much lower memory usage than standard single-core independent jobs. Exploiting this new processing model requires a new model in computing resource allocation, departing from the standard single-core allocation for a job. The experiment job management system needs to have control over a larger quantum of resource since multi-core aware jobs require the scheduling of multiples cores simultaneously. CMS is exploring the approach of using whole nodes as unit in the workload management system where all cores of a node are allocated to a multi-core job. Whole-node scheduling allows for optimization of the data/workflow management (e.g. I/O caching, local merging) but efficient utilization of all scheduled cores is challenging. Dedicated whole-node queues have been setup at all Tier-1 centers for exploring multi-core processing workflows in CMS. We present the evaluation of the performance scheduling and executing multi-core workflows in whole-node queues compared to the standard single-core processing workflows.

Adolescents' non-core food intake: a description of what, where and with whom adolescents consume non-core foods.

Science.gov (United States)

Toumpakari, Zoi; Haase, Anne M; Johnson, Laura

2016-06-01

Little is known about adolescents' non-core food intake in the UK and the eating context in which they consume non-core foods. The present study aimed to describe types of non-core foods consumed by British adolescents in total and across different eating contexts. A descriptive analysis, using cross-sectional data from food diaries. Non-core foods were classified based on cut-off points of fat and sugar from the Australian Guide to Healthy Eating. Eating context was defined as 'where' and 'with whom' adolescents consumed each food. Percentages of non-core energy were calculated for each food group in total and across eating contexts. A combined ranking was then created to account for each food's contribution to non-core energy intake and its popularity of consumption (percentage of consumers). The UK National Diet and Nutrition Survey 2008-2011. Adolescents across the UK aged 11-18 years (n 666). Non-core food comprised 39·5 % of total energy intake and was mostly 'Regular soft drinks', 'Crisps & savoury snacks', 'Chips & potato products', 'Chocolate' and 'Biscuits'. Adolescents ate 57·0 % and 51·3 % of non-core food at 'Eateries' or with 'Friends', compared with 33·2 % and 32·1 % at 'Home' or with 'Parents'. Persistent foods consumed across eating contexts were 'Regular soft drinks' and 'Chips & potato products'. Regular soft drinks contribute the most energy and are the most popular non-core food consumed by adolescents regardless of context, and represent a good target for interventions to reduce non-core food consumption.

Characteristics of core sampling from crumbing Paleozoic rock

Energy Technology Data Exchange (ETDEWEB)

Barabashkin, I I; Edelman, Y A; Filippov, V N; Lychev, V N

1981-01-01

The results of analysis of core sampling using standard core sampling tools with small and medium inside diameter are cited. It is demonstrated that when using these tools loss of core in Paleozoic deposits promising with regard to oil and gas content does not exceed 25 - 30%. The use of a new core sampling tool with a large inside diameter which includes drill bits of different types and a core lifter ''Krembriy'' SKU-172/100 made it possible to increase core removal approximately 52%. A representative core from a highly crumbling and vesicular rock belinging to groups III - IV in terms of difficulty of core sampling was obtained first. A description of a new core sampling tool is given. The characteristics of the technology of its use which promote preservation of the core are cited. Means of continued improvement of this tool are noted.

Conceptual core model for the reactor core test

International Nuclear Information System (INIS)

Swenson, L.D.

1970-01-01

Several design options for the ZrH Flight System Reactor were investigated which involved tradeoffs of core excess reactivity, reactor control, coolant mixing and cladding thickness. A design point was selected which is to be the basis for more detailed evaluation in the preliminary design phase. The selected design utilizes 295 elements with 0.670 inch element-to-element pitch, 32 mil thick Incoloy cladding, 18.00 inches long fuel meat, hydrogen content of 6.3 x 10 22 atoms/cc fuel, 10.5 w/o uranium, and a spiraled fin configuration with alternate elements having fins with spiral to the right, spiral to the left, and no fin at all (R-L-N fin configuration). Fin height is 30 mils for the center region of the core and 15 mils for the outer region. (U.S.)

A lock circuit for a multi-core processor

DEFF Research Database (Denmark)

2015-01-01

An integrated circuit comprising a multiple processor cores and a lock circuit that comprises a queue register with respective bits set or reset via respective, connections dedicated to respective processor cores, whereby the queue register identifies those among the multiple processor cores...... that are enqueued in the queue register. Furthermore, the integrated circuit comprises a current register and a selector circuit configured to select a processor core and identify that processor core by a value in the current register. A selected processor core is a prioritized processor core among the cores...... configured with an integrated circuit; and a silicon die configured with an integrated circuit....

Multi-core MgO NPs(at)C core-shell nanospheres for selective CO2 capture under mild conditions

International Nuclear Information System (INIS)

Tae Kyung Kim; Kyung Joo Lee; Hoi Ri Moon; Junhan Yuh; Sang Kyu Kwak

2014-01-01

The core-shell structures have attracted attention in catalysis, because the outer shells isolate the catalytically active NP cores and prevent the possibility of sintering of core particles during catalytic reaction under physically and chemically harsh conditions. We aimed to adopt this core-shell system for CO 2 sorption materials. In this study, a composite material of multi-core 3 nm-sized magnesium oxide nanoparticles embedded in porous carbon nanospheres (MgO NPs(at)C) was synthesized by a gas phase reaction via a solvent-free process. It showed selective CO 2 adsorption capacity over N 2 under mild regeneration conditions. (authors)

Core-to-core dimers forming switchable mesophase

Czech Academy of Sciences Publication Activity Database

Horčic, M.; Svoboda, J.; Novotná, Vladimíra; Pociecha, D.; Gorecka, E.

2017-01-01

Roč. 53, č. 18 (2017), s. 2721-2724 ISSN 1359-7345 R&D Projects: GA ČR GA15-02843S Institutional support: RVO:68378271 Keywords : liquid crystals * bent- core mesogens * dimers Subject RIV: JJ - Other Materials OBOR OECD: Nano-materials (production and properties) Impact factor: 6.319, year: 2016

Challenges Regarding IP Core Functional Reliability

Science.gov (United States)

Berg, Melanie D.; LaBel, Kenneth A.

2017-01-01

For many years, intellectual property (IP) cores have been incorporated into field programmable gate array (FPGA) and application specific integrated circuit (ASIC) design flows. However, the usage of large complex IP cores were limited within products that required a high level of reliability. This is no longer the case. IP core insertion has become mainstream including their use in highly reliable products. Due to limited visibility and control, challenges exist when using IP cores and subsequently compromise product reliability. We discuss challenges and suggest potential solutions to critical application IP insertion.

Validation of reactor core protection system

International Nuclear Information System (INIS)

Lee, Sang-Hoon; Bae, Jong-Sik; Baeg, Seung-Yeob; Cho, Chang-Ho; Kim, Chang-Ho; Kim, Sung-Ho; Kim, Hang-Bae; In, Wang-Kee; Park, Young-Ho

2008-01-01

Reactor COre Protection System (RCOPS), an advanced core protection calculator system, is a digitized one which provides core protection function based on two reactor core operation parameters, Departure from Nucleate Boiling Ratio (DNBR) and Local Power Density (LPD). It generates a reactor trip signal when the core condition exceeds the DNBR or LPD design limit. It consists of four independent channels adapted a two-out-of-four trip logic. System configuration, hardware platform and an improved algorithm of the newly designed core protection calculator system are described in this paper. One channel of RCOPS was implemented as a single channel facility for this R and D project where we performed final integration software testing. To implement custom function blocks, pSET is used. Software test is performed by two methods. The first method is a 'Software Module Test' and the second method is a 'Software Unit Test'. New features include improvement of core thermal margin through a revised on-line DNBR algorithm, resolution of the latching problem of control element assembly signal and addition of the pre-trip alarm generation. The change of the on-line DNBR calculation algorithm is considered to improve the DNBR net margin by 2.5%-3.3%. (author)

HTR core physics analysis at NRG

International Nuclear Information System (INIS)

Kuijper, J.C.; Haas, J.B.M. de; Oppe, J.

2002-01-01

Since a number of years NRG is developing the HTR reactor physics code system PANTHERMIX. In PANTHERMIX the 3-D steady-state and transient core physics code PANTHER has been interfaced with the HTR thermal hydraulics code THERMIX to enable core follow and transient analyses on both pebble bed and block type HTR systems. Recently the capabilities of PANTHERMIX have been extended with the possibility to simulate the flow of pebbles through the core cavity and the (re)loading of pebbles on top of the core.The PANTHERMIX code system is being applied for the benchmark exercises for the Chinese HTR-10 and Japanese HTTR first criticality, calculating the critical loading, control rod worth and the isothermal temperature coefficients at zero power conditions. Also core physics calculations have been performed on an early version the South African PBMR design. The reactor physics properties of the reactor at equilibrium core loading have been studied as well as a selected run-in scenario, starting form fresh fuel. The recently developed reload option of PANTHERMIX was used extensively in these analyses. The examples shown demonstrate the capabilities of PANTHERMIX for performing steady-state and transient HTR core physics analyses. However, additional validation, especially for transient analyses, remains desirable. (author)

Early-type galaxy core phase densities

International Nuclear Information System (INIS)

Carlberg, R. G.; Hartwick, F. D. A.

2014-01-01

Early-type galaxies have projected central density brightness profile logarithmic slopes, γ', ranging from about 0 to 1. We show that γ' is strongly correlated, r = 0.83, with the coarse grain phase density of the galaxy core, Q 0 ≡ ρ/σ 3 . The luminosity-γ' correlation is much weaker, r = –0.51. Q 0 also serves to separate the distribution of steep core profiles, γ' > 0.5, from shallow profiles, γ' < 0.3, although there are many galaxies of intermediate slope, at intermediate Q 0 , in a volume-limited sample. The transition phase density separating the two profile types is approximately 0.003 M ☉ pc –3 km –3 s 3 , which is also where the relation between Q 0 and core mass shows a change in slope, the rotation rate of the central part of the galaxy increases, and the ratio of the black hole to core mass increases. These relations are considered relative to the globular cluster inspiral core buildup and binary black hole core scouring mechanisms for core creation and evolution. Mass-enhanced globular cluster inspiral models have quantitative predictions that are supported by data, but no single model yet completely explains the correlations.

Development of core design technology for LMR

Energy Technology Data Exchange (ETDEWEB)

Kim, Young Jin; Kim Young In; Kim, Young Il; Kim, Y. G.; Kim, S. J.; Song, H.; Kim, T. K.; Kim, W. S.; Hwang, W.; Lee, B. O.; Park, C. K.; Joo, H. K.; Yoo, J. W.; Kang, H. Y.; Park, W. S

2000-05-01

For the development of KALIMER (150 MWe) core conceptual design, design evolution and optimization for improved economics and safety enhancement was performed in the uranium metallic fueled equilibrium core design which uses U-Zr binary fuel not in excess of 20 percent enrichment. Utilizing results of the uranium ,metallic fueled core design, the breeder equilibrium core design with breeding ratio being over 1.1 was developed. In addition, utilizing LMR's excellent neutron economy, various core concepts for minor actinide burnup, inherent safety, economics and non-proliferation were realized and its optimization studies were performed. A code system for the LMR core conceptual design has been established through the implementation of needed functions into the existing codes and development of codes. To improve the accuracy of the core design, a multi-dimensional nodal transport code SOLTRAN, a three-dimensional transient code analysis code STEP, MATRA-LMR and ASSY-P for T/H analysis are under development. Through the automation of design calculations for efficient core design, an input generator and several interface codes have been developed. (author)

Development of core design technology for LMR

Energy Technology Data Exchange (ETDEWEB)

Kim, Young Jin; In, Kim Young; Kim, Young Il; Kim, Y G; Kim, S J; Song, H; Kim, T K; Kim, W S; Hwang, W; Lee, B O; Park, C K; Joo, H K; Yoo, J W; Kang, H Y; Park, W S

2000-05-01

For the development of KALIMER (150 MWe) core conceptual design, design evolution and optimization for improved economics and safety enhancement was performed in the uranium metallic fueled equilibrium core design which uses U-Zr binary fuel not in excess of 20 percent enrichment. Utilizing results of the uranium ,metallic fueled core design, the breeder equilibrium core design with breeding ratio being over 1.1 was developed. In addition, utilizing LMR's excellent neutron economy, various core concepts for minor actinide burnup, inherent safety, economics and non-proliferation were realized and its optimization studies were performed. A code system for the LMR core conceptual design has been established through the implementation of needed functions into the existing codes and development of codes. To improve the accuracy of the core design, a multi-dimensional nodal transport code SOLTRAN, a three-dimensional transient code analysis code STEP, MATRA-LMR and ASSY-P for T/H analysis are under development. Through the automation of design calculations for efficient core design, an input generator and several interface codes have been developed. (author)

Whole core transport calculation for the VHTR hexagonal core

International Nuclear Information System (INIS)

Cho, J. Y.; Kim, K. S.; Lee, C. C.; Joo, H. G.

2007-01-01

Recently, the DeCART code which performs the whole core calculation by coupling the radial MOC transport kernel with the axial nodal kernel has equipped a kernel to deal with the hexagonal geometry and applied to the VHTR hexagonal core to examine the accuracy and the computational efficiency of the implemented kernel. The implementation includes a modular ray tracing module based on the hexagonal assembly and a multi-group CMFD module to perform an efficient transport calculation. The requirements for the modular ray are: (1) the assembly based path linking and (2) the complete reflection capabilities. The first requirement is met by adjusting the azimuthal angle and the ray spacing for the modular ray to construct a core ray by the path linking. The second requirement is met by expanding the constructed azimuthal angle in the range of [0,30 degree] to the remained range to reflect completely at the core boundaries. The considered reflecting surface angles for the complete reflection are 30n's (n=1,2,1,12). The CMFD module performs the equivalent diffusion calculation to the radial MOC transport calculation based on the homogenized structure units. The structure units include the hexagonal pin cells and gap cells appearing at the assembly boundary. Therefore, the CMFD module is programmed to deal with the unstructured cells such as the gap cells. The CMFD equation consists of the two parts of (1) the conventional FDM and (2) the current corrective parts. Since the second part of the CMFD equation guarantees the reproducibility of the radial MOC transport solutions for the cell averaged reaction rate and the net current at the cell surfaces, how to build the first part of the CMFD equation is not important. Therefore, the first part of the CMFD equation is roughly built by using the normal distance from the gravity center to the surface. The VHTR core uses helium as a coolant which is realized as a void hole in a neutronics calculation. This void hole which

Organizing Core Tasks

DEFF Research Database (Denmark)

Boll, Karen

has remained much the same within the last 10 years. However, how the core task has been organized has changed considerable under the influence of various “organizing devices”. The paper focusses on how organizing devices such as risk assessment, output-focus, effect orientation, and treatment...... projects influence the organization of core tasks within the tax administration. The paper shows that the organizational transformations based on the use of these devices have had consequences both for the overall collection of revenue and for the employees’ feeling of “making a difference”. All in all...

The BioFIND study: Characteristics of a clinically typical Parkinson's disease biomarker cohort

Science.gov (United States)

Goldman, Jennifer G.; Alcalay, Roy N.; Xie, Tao; Tuite, Paul; Henchcliffe, Claire; Hogarth, Penelope; Amara, Amy W.; Frank, Samuel; Rudolph, Alice; Casaceli, Cynthia; Andrews, Howard; Gwinn, Katrina; Sutherland, Margaret; Kopil, Catherine; Vincent, Lona; Frasier, Mark

2016-01-01

ABSTRACT Background Identifying PD‐specific biomarkers in biofluids will greatly aid in diagnosis, monitoring progression, and therapeutic interventions. PD biomarkers have been limited by poor discriminatory power, partly driven by heterogeneity of the disease, variability of collection protocols, and focus on de novo, unmedicated patients. Thus, a platform for biomarker discovery and validation in well‐characterized, clinically typical, moderate to advanced PD cohorts is critically needed. Methods BioFIND (Fox Investigation for New Discovery of Biomarkers in Parkinson's Disease) is a cross‐sectional, multicenter biomarker study that established a repository of clinical data, blood, DNA, RNA, CSF, saliva, and urine samples from 118 moderate to advanced PD and 88 healthy control subjects. Inclusion criteria were designed to maximize diagnostic specificity by selecting participants with clinically typical PD symptoms, and clinical data and biospecimen collection utilized standardized procedures to minimize variability across sites. Results We present the study methodology and data on the cohort's clinical characteristics. Motor scores and biospecimen samples including plasma are available for practically defined off and on states and thus enable testing the effects of PD medications on biomarkers. Other biospecimens are available from off state PD assessments and from controls. Conclusion Our cohort provides a valuable resource for biomarker discovery and validation in PD. Clinical data and biospecimens, available through The Michael J. Fox Foundation for Parkinson's Research and the National Institute of Neurological Disorders and Stroke, can serve as a platform for discovering biomarkers in clinically typical PD and comparisons across PD's broad and heterogeneous spectrum. © 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society PMID:27113479

Computer-Aided Test Flow in Core-Based Design

OpenAIRE

Zivkovic, V.; Tangelder, R.J.W.T.; Kerkhoff, Hans G.

2000-01-01

This paper copes with the test-pattern generation and fault coverage determination in the core based design. The basic core-test strategy that one has to apply in the core-based design is stated in this work. A Computer-Aided Test (CAT) flow is proposed resulting in accurate fault coverage of embedded cores. The CAT now is applied to a few cores within the Philips Core Test Pilot IC project

Constraints on the coupled thermal evolution of the Earth's core and mantle, the age of the inner core, and the origin of the 186Os/188Os “core signal” in plume-derived lavas

Science.gov (United States)

Lassiter, J. C.

2006-10-01

The possibility that some mantle plumes may carry a geochemical signature of core/mantle interaction has rightly generated considerable interest and attention in recent years. Correlated 186Os- 187Os enrichments in some plume-derived lavas (Hawaii, Gorgona, Kostomuksha) have been interpreted as deriving from an outer core with elevated Pt/Os and Re/Os ratios due to the solidification of the Earth's inner core (c.f., [A.D. Brandon, R.J. Walker, The debate over core-mantle interaction, Earth Planet. Sci. Lett. 232 (2005) 211-225.] and references therein). Conclusive identification of a "core signal" in plume-derived lavas would profoundly influence our understanding of mantle convection and evolution. This paper reevaluates the Os-isotope evidence for core/mantle interaction by examining other geochemical constraints on core/mantle interaction, geophysical constraints on the thermal evolution of the outer core, and geochemical and cosmochemical constraints on the abundance of heat-producing elements in the core. Additional study of metal/silicate and sulfide/silicate partitioning of K, Pb, and other trace elements is needed to more tightly constrain the likely starting composition of the Earth's core. However, available data suggest that the observed 186Os enrichments in Hawaiian and other plume-derived lavas are unlikely to derive from core/mantle interaction. 1) Core/mantle interaction sufficient to produce the observed 186Os enrichments would likely have significant effects on other tracers such as Pb- and W-isotopes that are not observed. 2) Significant partitioning of K or other heat-producing elements into the core would produce a "core depletion" pattern in the Silicate Earth very different from that observed. 3) In the absence of heat-producing elements in the core, core/mantle heat flow of ˜ 6-15 TW estimated from several independent geophysical constraints suggests an inner core age (< ˜ 2.5 Ga) too young for the outer core to have developed a significant

Molten core retention assembly

International Nuclear Information System (INIS)

Lampe, R.F.

1976-01-01

Molten fuel produced in a core overheating accident is caught by a molten core retention assembly consisting of a horizontal baffle plate having a plurality of openings therein, heat exchange tubes having flow holes near the top thereof mounted in the openings, and a cylindrical imperforate baffle attached to the plate and surrounding the tubes. The baffle assembly is supported from the core support plate of the reactor by a plurality of hanger rods which are welded to radial beams passing under the baffle plate and intermittently welded thereto. Preferably the upper end of the cylindrical baffle terminates in an outwardly facing lip to which are welded a plurality of bearings having slots therein adapted to accept the hanger rods

Standard operating procedures for female orgasmic disorder: consensus of the International Society for Sexual Medicine

NARCIS (Netherlands)

Laan, Ellen; Rellini, Alessandra H.; Barnes, Tricia

2013-01-01

As the field of sexual medicine evolves, it is important to continually improve patient care by developing contemporary "standard operating procedures" (SOPs), reflecting the consensus view of experts in sexual medicine. Few, if any, consensus SOPs have been developed for the diagnosis and treatment

Bulimia nerviosa

Science.gov (United States)

... Virus del papiloma humano (VPH) Infertilidad Síndrome de ovario poliquístico (SOP) Infecciones de transmisión sexual (ITS) Fibromas ... Virus del papiloma humano (VPH) Infertilidad Síndrome de ovario poliquístico (SOP) Infecciones de transmisión sexual (ITS) Fibromas ...

Ice Cores

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Records of past temperature, precipitation, atmospheric trace gases, and other aspects of climate and environment derived from ice cores drilled on glaciers and ice...

Analysis of L-serine-O-phosphate in cerebrospinal spinal fluid by derivatization-liquid chromatography/mass spectrometry.

Science.gov (United States)

McNaney, Colleen A; Benitex, Yulia; Luchetti, David; Labasi, Jeffrey M; Olah, Timothy V; Morgan, Daniel G; Drexler, Dieter M

2014-05-01

L-serine-O-phosphate (L-SOP), the precursor of L-serine, is a potent agonist against the group III metabotropic glutamate receptors (mGluRs) and, thus, is of interest as a potential biomarker for monitoring modulation of neurotransmitter release. So far, no reports are available on the analysis of L-SOP in cerebrospinal fluid (CSF). Here a novel method is presented to determine L-SOP levels in CSF employing precolumn derivatization with (5-N-succinimidoxy-5-oxopentyl)triphenylphosphonium bromide (SPTPP) coupled to liquid chromatography/mass spectrometry (derivatization-LC/MS, d-LC/MS). Copyright © 2014 Elsevier Inc. All rights reserved.

The whiteStar development project: Westinghouse's next generation core design simulator and core monitoring software to power the nuclear renaissance

International Nuclear Information System (INIS)

Boyd, W. A.; Mayhue, L. T.; Penkrot, V. S.; Zhang, B.

2009-01-01

The WhiteStar project has undertaken the development of the next generation core analysis and monitoring system for Westinghouse Electric Company. This on-going project focuses on the development of the ANC core simulator, BEACON core monitoring system and NEXUS nuclear data generation system. This system contains many functional upgrades to the ANC core simulator and BEACON core monitoring products as well as the release of the NEXUS family of codes. The NEXUS family of codes is an automated once-through cross section generation system designed for use in both PWR and BWR applications. ANC is a multi-dimensional nodal code for all nuclear core design calculations at a given condition. ANC predicts core reactivity, assembly power, rod power, detector thimble flux, and other relevant core characteristics. BEACON is an advanced core monitoring and support system which uses existing instrumentation data in conjunction with an analytical methodology for on-line generation and evaluation of 3D core power distributions. This new system is needed to design and monitor the Westinghouse AP1000 PWR. This paper describes provides an overview of the software system, software development methodologies used as well some initial results. (authors)

Evaluation of the influence of bypass flow gap distribution on the core hot spot in a prismatic VHTR core

International Nuclear Information System (INIS)

Kim, Min-Hwan; Lim, Hong-Sik

2011-01-01

Highlights: → A procedure to evaluate the local gap size variation between graphite blocks was developed and applied to a prismatic core VHTR. → The analysis for the core bypass flow and hot spot was carried out based on the calculated gap distributions. → The predicted gap size is large enough to affect the flow distribution in the core. → The bypass gap and flow distributions are closely related to the local hot spot temperature and its location. → The core restraint mechanism preventing outward movement of graphite block reduces the bypass gap size and hot spot temperature. - Abstract: Core bypass flow in VHTR is one of the key issues for core thermal margins and efficiency. The bypass flow in the prismatic core varies during core cycles due to the irradiation shrinkage/swelling and thermal expansion of the graphite blocks. A procedure to evaluate the local gap size variation between graphite blocks was developed and applied to a prismatic core VHTR. The influence of the core restraint mechanism on the bypass flow gap was evaluated. The predicted gap size is as much as 8 mm when the graphite block is exposed to its allowable limit of fast neutron fluence. The analysis for the core bypass flow and hot spot was carried out based on the calculated gap distributions. The results indicate that the bypass gap and flow distributions are closely related to the local hot spot and its location and the core restraint mechanism preventing outward movement of the graphite block by a fastening device reduces the bypass gap size, which results in the decrease of maximum fuel temperature not less than 100 deg. C, when compared to the case without it.

Self-organization of single filaments and diffusive plasmas during a single pulse in dielectric-barrier discharges

International Nuclear Information System (INIS)

Babaeva, Natalia Yu; Kushner, Mark J

2014-01-01

Self-organization of filaments in dielectric-barrier discharges (DBDs) probably has many origins. However, the dominant cause is proposed to be the accumulation of charge on the surfaces of the bounding dielectrics that reinforces successive discharge pulses to occur at the same locations. A secondary cause is the electrostatic repulsion of individual plasma filaments. Self-organization typically develops over many discharge pulses. In this paper, we discuss the results of a computational investigation of plasma filaments in overvoltage DBDs that, under select conditions, display self-organized patterns (SOPs) of plasma density during a single discharge pulse. (Overvoltage refers to the rapid application of a voltage in excess of the quasi-dc breakdown voltage.) The origin of the SOPs is a synergistic relationship between the speed of the surface-ionization waves that propagate along each dielectric and the rate at which avalanche occurs across the gap. For our test conditions, SOPs were not observed at lower voltages and gradually formed at higher voltages. The same conditions that result in SOPs, i.e. the application of an overvoltage, also produce more diffuse discharges. A transition from a single narrow filament to a more diffuse structure was observed as overvoltage was approached. The sensitivity of SOPs to the orientation and permittivity of the bounding dielectrics is discussed. (paper)

Calculating vibrational spectra with sum of product basis functions without storing full-dimensional vectors or matrices.

Science.gov (United States)

Leclerc, Arnaud; Carrington, Tucker

2014-05-07

We propose an iterative method for computing vibrational spectra that significantly reduces the memory cost of calculations. It uses a direct product primitive basis, but does not require storing vectors with as many components as there are product basis functions. Wavefunctions are represented in a basis each of whose functions is a sum of products (SOP) and the factorizable structure of the Hamiltonian is exploited. If the factors of the SOP basis functions are properly chosen, wavefunctions are linear combinations of a small number of SOP basis functions. The SOP basis functions are generated using a shifted block power method. The factors are refined with a rank reduction algorithm to cap the number of terms in a SOP basis function. The ideas are tested on a 20-D model Hamiltonian and a realistic CH3CN (12 dimensional) potential. For the 20-D problem, to use a standard direct product iterative approach one would need to store vectors with about 10(20) components and would hence require about 8 × 10(11) GB. With the approach of this paper only 1 GB of memory is necessary. Results for CH3CN agree well with those of a previous calculation on the same potential.

Body weight loss by very-low-calorie diet program improves small artery reactive hyperemia in severely obese patients.

Science.gov (United States)

Merino, J; Megias-Rangil, I; Ferré, R; Plana, N; Girona, J; Rabasa, A; Aragonés, G; Cabré, A; Bonada, A; Heras, M; Masana, L

2013-01-01

Endothelial dysfunction is a major underlying mechanism for the elevated cardiovascular risk associated with increased body weight. We aimed to assess the impact of weight loss induced by an intensive very-low-calorie diet (VLCD) on arterial wall function in severely obese patients (SOP). Thirty-four SOP were admitted to the metabolic ward of the hospital for a 3-week period. A VLCD characterized by a liquid diet providing 800 kcal/day was administered. The small artery reactivity to postischemic hyperemia index (saRHI), a surrogate marker of endothelial function, was assessed before and 1 week after hospital discharge. Anthropometry and biochemical parameters were also measured. Obese and non-obese age- and gender-matched groups were recruited for baseline comparisons. SOP had significantly lower saRHI compared with obese and non-obese individuals. SaRHI significantly increased after the intervention in SOP (1.595 ± 0.236 vs. 1.737 ± 0.417, p = 0.015). A significant improvement in glucose (p = 0.026), systolic blood pressure (p = 0.049), LDLc (p reactivity, and it was associated with the amelioration of metabolic and inflammation markers. Endothelial dysfunction may be softened by body weight loss interventions and useful in the management of cardiovascular risk factors in SOP.

Improving Core Strength to Prevent Injury

Science.gov (United States)

Oliver, Gretchen D.; Adams-Blair, Heather R.

2010-01-01

Regardless of the sport or skill, it is essential to have correct biomechanical positioning, or postural control, in order to maximize energy transfer. Correct postural control requires a strong, stable core. A strong and stable core allows one to transfer energy effectively as well as reduce undue stress. An unstable or weak core, on the other…

Emergency core cooling system

International Nuclear Information System (INIS)

Kato, Ken.

1989-01-01

In PWR type reactors, a cooling water spray portion of emergency core cooling pipelines incorporated into pipelines on high temperature side is protruded to the inside of an upper plenum. Upon rupture of primary pipelines, pressure in a pressure vessel is abruptly reduced to generate a great amount of steams in the reactor core, which are discharged at a high flow rate into the primary pipelines on high temperature side. However, since the inside of the upper plenum has a larger area and the steam flow is slow, as compared with that of the pipelines on the high temperature side, ECCS water can surely be supplied into the reactor core to promote the re-flooding of the reactor core and effectively cool the reactor. Since the nuclear reactor can effectively be cooled to enable the promotion of pressure reduction and effective supply of coolants during the period of pressure reduction upon LOCA, the capacity of the pressure accumulation vessel can be decreased. Further, the re-flooding time for the reactor is shortened to provide an effect contributing to the improvement of the safety and the reduction of the cost. (N.H.)

Reflood behavior at low initial clad temperature in Slab Core Test Facility Core-II

International Nuclear Information System (INIS)

Akimoto, Hajime; Sobajima, Makoto; Abe, Yutaka; Iwamura, Takamichi; Ohnuki, Akira; Okubo, Tsutomu; Murao, Yoshio; Okabe, Kazuharu; Adachi, Hiromichi.

1990-07-01

In order to study the reflood behavior with low initial clad temperature, a reflood test was performed using the Slab Core Test Facility (SCTF) with initial clad temperature of 573 K. The test conditions of the test are identical with those of SCTF base case test S2-SH1 (initial clad temperature 1073 K) except the initial clad temperature. Through the comparison of results from these two tests, the following conclusions were obtained. (1) The low initial clad temperature resulted in the low differential pressures through the primary loops due to smaller steam generation in the core. (2) The low initial clad temperature caused the accumulated mass in the core to be increased and the accumulated mass in the downcomer to be decreased in the period of the lower plenum injection with accumulator (before 50s). In the later period of the cold leg injection with LPCI (after 100s), the water accumulation rates in the core and the downcomer were almost the same between both tests. (3) The low initial clad temperature resulted in the increase of the core inlet mass flow rate in the lower plenum injection period. However, the core inlet mass flow rate was almost the same regardless of the initial clad temperature in the later period of the cold leg injection period. (4) The low initial clad temperature resulted in the low turnaround temperature, high temperature rise and fast bottom quench front propagation. (5) In the region apart from the quench front, low initial clad temperature resulted in the lower heat transfer. In the region near the quench front, almost the same heat transfer coefficient was observed between both tests. (6) No flow oscillation with a long period was observed in the SCTF test with low initial clad temperature of 573 K, while it was remarkable in the Cylindrical Core Test Facility (CCTF) test which was performed with the same initial clad temperature. (J.P.N.)

Advantages of iron core in a tokamak

International Nuclear Information System (INIS)

Bettis, E.S.; Ballou, J.K.; Becraft, W.R.; Peng, Y.K.M.; Watts, H.L.

1977-01-01

A quantitative comparison of the iron core vs air core concepts was carried out on a preliminary basis by using a representative tokamak reactor design with the following self-consistent reference parameters. In the area of plasma engineering, poloidal field and MHD equilibrium considerations with an unsaturated iron core is discussed. The question of proper poloidal field coils to maintain D-shaped plasmas of relatively high anti β (7%) with a saturated iron core is also discussed. Estimates of the required iron core size, volt seconds, magnetic flux and its influence on force loading on the superconducting toroidal field coils are shown. Conceptual designs of the mechanical structure of an iron core device are presented. Favorable impacts on the OH power supply cost and complexity are indicated

Controlled fabrication of multi-core alginate microcapsules.

Science.gov (United States)

Eqbal, Md Danish; Gundabala, Venkat

2017-12-01

In this work, we present a robust microfluidic platform for controlled and complete on-chip generation of alginate microcapsules with single and double liquid cores. A combined Coflow and T-junction configuration implemented in a hybrid glass-PDMS (Polydimethylsiloxane) device is used for the generation of microcapsules with oil as liquid core. Frequency matching of oil-alginate double emulsion generation with that of aqueous Calcium chloride droplet generation allows for controlled merging of the two, resulting in reliable production of microcapsules. Confocal imaging of microcapsule cross-section reveals presence of intact liquid core. In the case of double core microcapsules, the two cores are well separated by alginate layer ensuring their long term stability. The current approach is expected to have advantages over existing techniques for liquid core microcapsule generation in terms of continuity of the process, control over core stability, and non-damage to cells when used for cell encapsulation applications. Copyright © 2017 Elsevier Inc. All rights reserved.

Nonlinear Model of Tape Wound Core Transformers

Directory of Open Access Journals (Sweden)

A. Vahedi

2015-03-01

Full Text Available Recently, tape wound cores due to their excellent magnetic properties, are widely used in different types of transformers. Performance prediction of these transformers needs an accurate model with ability to determine flux distribution within the core and magnetic loss. Spiral structure of tape wound cores affects the flux distribution and always cause complication of analysis. In this paper, a model based on reluctance networks method is presented for analysis of magnetic flux in wound cores. Using this model, distribution of longitudinal and transverse fluxes within the core can be determined. To consider the nonlinearity of the core, a dynamic hysteresis model is included in the presented model. Having flux density in different points of the core, magnetic losses can be calculated. To evaluate the validity of the model, results are compared with 2-D FEM simulations. In addition, a transformer designed for series-resonant converter and simulation results are compared with experimental measurements. Comparisons show accuracy of the model besides simplicity and fast convergence

Experimentation of a fixed in-core-based system for core limiting conditions of operation (LCO) monitoring

International Nuclear Information System (INIS)

Piguet, F.; Carrasco, M.; Mourlevat, J.L.; Rio, G.; Verneret, C.

2006-01-01

In order to comply with the needs of Utilities for improvements in the economic competitiveness of nuclear energy, one of the solutions proposed is to reduce the cost of the fuel cycle. To this aim, increasing the lifetime of cycles by introducing so-called 'low leakage' fuel loading patterns to the reactor is a rather promising solution. However, these loading patterns lead to an increase in the core hotspot factors and therefore to a reduction in the operating margins with respect to the core operating limits also called 'Limiting Conditions of Operations (LCO)'. For many years FRAMATOME-ANP has developed and proposed solutions aiming at increasing and therefore restoring these margins, namely: the improvement in design methods based on three-dimensional modelling of the core, on kinetic representation of transients and on neutron-thermohydraulic coupling or the improvement in the fuel with the introduction of intermediate grids. A complementary approach is to improve the core instrumentation associated with the system for monitoring the core operating margins to the LCO thresholds. The core operating limits monitoring function calls on real-time knowledge of the current power distribution in the core. If we take the French 1300 MWe units as an example, this knowledge is based on the measurement of the mean axial power distribution made by six sections neutron detectors, located outside the pressure vessel and equipped with a fast neutron filtering device. The results of this measurement are combined with pre-tabulated radial hotspot factors (Fxy), in order to calculate the total hotspot factor (FQ) of the core, the minimum Departure from Nucleate Boiling Ratio (DNBR) and, consequently, the margins with respect to the core operating limits. The limitations of a measurement made outside the vessel, and those of the 1D/2D modelling adopted, mean that these margins calculations have a high potential for improving the level of their accuracy. This is the reason why

3D core burnup studies in 500 MWe Indian prototype fast breeder reactor to attain enhanced core burnup

International Nuclear Information System (INIS)

Choudhry, Nakul; Riyas, A.; Devan, K.; Mohanakrishnan, P.

2013-01-01

Highlights: ► Enhanced burnup potential of existing prototype fast breeder reactor core is studied. ► By increasing the Pu enrichment, fuel burnup can be increased in existing PFBR core. ► Enhanced burnup increase economy and reduce load of fuel fabrication and reprocessing. ► Beginning of life reactivity is suppressed by increasing the number of diluents. ► Absorber rod worth requirements can be achieved by increasing 10 B enrichment. -- Abstract: Fast breeder reactors are capable of producing high fuel burnup because of higher internal breeding of fissile material and lesser parasitic capture of neutrons in the core. As these reactors need high fissile enrichment, high fuel burnup is desirable to be cost effective and to reduce the load on fuel reprocessing and fabrication plants. A pool type, liquid sodium cooled, mixed (Pu–U) oxide fueled 500 MWe prototype fast breeder reactor (PFBR), under construction at Kalpakkam is designed for a peak burnup of 100 GWd/t. This limitation on burnup is purely due to metallurgical properties of structural materials like clad and hexcan to withstand high neutron fluence, and not by the limitation on the excess reactivity available in the core. The 3D core burnup studies performed earlier for approach to equilibrium core of PFBR is continued to demonstrate the burnup potential of existing PFBR core. To increase the fuel burnup of PFBR, plutonium oxide enrichment is increased from 20.7%/27.7% to 22.1%/29.4% of core-1/core-2 which resulted in cycle length increase from 180 to 250 effective full power days (efpd), so that the peak fuel burnup increases from 100 to 134 GWd/t, keeping all the core parameters under allowed safety limits. Number of diluents subassemblies is increased from eight to twelve at beginning of life core to bring down the initial core excess reactivity. PFBR refueling is revised to accommodate twelve diluents. Increase of 10 B enrichment in control safety rods (CSRs) and diverse safety rods (DSRs

CORE: a phylogenetically-curated 16S rDNA database of the core oral microbiome.

Directory of Open Access Journals (Sweden)

Ann L Griffen

2011-04-01

Full Text Available Comparing bacterial 16S rDNA sequences to GenBank and other large public databases via BLAST often provides results of little use for identification and taxonomic assignment of the organisms of interest. The human microbiome, and in particular the oral microbiome, includes many taxa, and accurate identification of sequence data is essential for studies of these communities. For this purpose, a phylogenetically curated 16S rDNA database of the core oral microbiome, CORE, was developed. The goal was to include a comprehensive and minimally redundant representation of the bacteria that regularly reside in the human oral cavity with computationally robust classification at the level of species and genus. Clades of cultivated and uncultivated taxa were formed based on sequence analyses using multiple criteria, including maximum-likelihood-based topology and bootstrap support, genetic distance, and previous naming. A number of classification inconsistencies for previously named species, especially at the level of genus, were resolved. The performance of the CORE database for identifying clinical sequences was compared to that of three publicly available databases, GenBank nr/nt, RDP and HOMD, using a set of sequencing reads that had not been used in creation of the database. CORE offered improved performance compared to other public databases for identification of human oral bacterial 16S sequences by a number of criteria. In addition, the CORE database and phylogenetic tree provide a framework for measures of community divergence, and the focused size of the database offers advantages of efficiency for BLAST searching of large datasets. The CORE database is available as a searchable interface and for download at http://microbiome.osu.edu.

Magnetic Fields in the Massive Dense Cores of the DR21 Filament: Weakly Magnetized Cores in a Strongly Magnetized Filament

Energy Technology Data Exchange (ETDEWEB)

Ching, Tao-Chung; Lai, Shih-Ping [Institute of Astronomy and Department of Physics, National Tsing Hua University, Hsinchu 30013, Taiwan (China); Zhang, Qizhou; Girart, Josep M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge MA 02138 (United States); Qiu, Keping [School of Astronomy and Space Science, Nanjing University, 163 Xianlin Avenue, Nanjing 210023 (China); Liu, Hauyu B., E-mail: chingtaochung@gmail.com [European Southern Observatory (ESO), Karl-Schwarzschild-Str. 2, D-85748 Garching (Germany)

2017-04-01

We present Submillimeter Array 880 μ m dust polarization observations of six massive dense cores in the DR21 filament. The dust polarization shows complex magnetic field structures in the massive dense cores with sizes of 0.1 pc, in contrast to the ordered magnetic fields of the parsec-scale filament. The major axes of the massive dense cores appear to be aligned either parallel or perpendicular to the magnetic fields of the filament, indicating that the parsec-scale magnetic fields play an important role in the formation of the massive dense cores. However, the correlation between the major axes of the cores and the magnetic fields of the cores is less significant, suggesting that during the core formation, the magnetic fields below 0.1 pc scales become less important than the magnetic fields above 0.1 pc scales in supporting a core against gravity. Our analysis of the angular dispersion functions of the observed polarization segments yields a plane-of-sky magnetic field strength of 0.4–1.7 mG for the massive dense cores. We estimate the kinematic, magnetic, and gravitational virial parameters of the filament and the cores. The virial parameters show that the gravitational energy in the filament dominates magnetic and kinematic energies, while the kinematic energy dominates in the cores. Our work suggests that although magnetic fields may play an important role in a collapsing filament, the kinematics arising from gravitational collapse must become more important than magnetic fields during the evolution from filaments to massive dense cores.

Factor analysis of the scale of prodromal symptoms: differentiating between negative and depression symptoms

NARCIS (Netherlands)

Klaassen, Rianne M. C.; Velthorst, Eva; Nieman, Dorien H.; de Haan, Lieuwe; Becker, Hiske E.; Dingemans, Peter M.; van de Fliert, J. Reinaud; van der Gaag, Mark; Linszen, Don H.

2011-01-01

This study examines the ability of the Scale of Prodromal Symptoms (SOPS) to differentiate between negative and depression symptoms in a young help-seeking ultrahigh risk (UHR) group. SOPS data of 77 help-seeking patients at UHR for psychosis were analyzed with an exploratory factor analysis. The

Sales and operations planning

DEFF Research Database (Denmark)

Kjellsdotter, Linea; Dukovska-Popovska, Iskra; Kaipia, Riikka

2013-01-01

This paper explores how the use of sales and operations planning (S&OP) may deal with the challenges set by the planning environment by investigating S&OP at four Scandinavian industrial food producers. Variables connected to the product and market, e.g. perishability, customer service elements...

Two-dimensional thermal-hydraulic behavior in core in SCTF Core-II cold leg injection tests

International Nuclear Information System (INIS)

Iwamura, Takamichi; Sobajima, Makoto; Okubo, Tsutomu; Ohnuki, Akira; Abe, Yutaka; Adachi, Hiromichi

1985-07-01

Major purpose of the Slab Core Test Program is to investigate the two-dimensional thermal-hydraulic behavior in the core during the reflood phase in a PWR-LOCA. In order to investigate the effects of radial power profile, three cold leg injection tests with different radial power profiles under the same total heating power and core stored energy were performed by using the Slab Core Test Facility (SCTF) Core-II. It was revealed by comparing these three tests that the heat transfer was enhanced in the higher power bundles and degraded in the lower power bundles in the non-uniform radial power profile tests. The turnaround temperature in the high power bundles were evaluated to be reduced by about 40 to 120 K. On the other hand, a two-dimensional flow in the core was also induced by the non-uniform water accumulation in the upper plenum and the quench was delayed resultantly in the bundles corresponding to the peripheral bundles of a PWR. However, the effect of the non-uniform upper plenum water accumulation on the turnaround temperature was small because the effect dominated after the turnaround of the cladding temperature. Selected data from Tests S2-SH1, S2-SH2 and S2-O6 are also presented in this report. Some data from Tests S2-SH1 and S2-SH2 were compared with TRAC post-test calculations performed by the Los Alamos National Laboratory. (author)

Two-dimensional thermal-hydraulic behavior in core in SCTF Core-II forced feed reflood tests

International Nuclear Information System (INIS)

Iwamura, Takamichi; Sobajima, Makoto; Okubo, Tsutomu; Ohnuki, Akira; Abe, Yutaka; Adachi, Hiromichi

1987-01-01

Major purpose of the Slab Core Test Program is to investigate the two-dimensional thermal-hydraulic behavior in the core during the reflood phase of a PWR-LOCA. It was revealed in the previous Slab Core Test Facility (SCTF) Core-II test results that the heat transfer was enhanced in the higher power bundles and degraded in the lower power bundles in the non-uniform radial power profile tests. In order to separately evaluate the effect of the radial power (Q) distribution itself and the effect of the radial temperature (T) distribution, four tests were performed with steep Q and T, flat Q and T, steep Q and flat T, and flat Q and steep T. Based on the test results, it was concluded that the radial temperature distribution which accompanied the radial power distribution was the dominant factor of the two-dimensional thermal-hydraulic behavior in the core during the initial period. Selected data from these four tests are also presented in this report. Some data from Test S2-12 (steep Q, T) were compared with TRAC post-test calculations performed by the Los Alamos National Laboratory. (author)

Influence of core-finishing intervals on tensile strength of cast posts-and-cores luted with zinc phosphate cement

Directory of Open Access Journals (Sweden)

Michele Andrea Lopes Iglesias

2012-08-01

Full Text Available The core finishing of cast posts-and-cores after luting is routine in dental practice. However, the effects of the vibrations produced by the rotary cutting instruments over the luting cements are not well-documented. This study evaluated the influence of the time intervals that elapsed between the cementation and the core-finishing procedures on the tensile strength of cast posts-and-cores luted with zinc phosphate cement. Forty-eight bovine incisor roots were selected, endodontically treated, and divided into four groups (n = 12: GA, control (without finishing; GB, GC, and GD, subjected to finishing at 20 minutes, 60 minutes, and 24 hours after cementation, respectively. Root canals were molded, and the resin patterns were cast in copper-aluminum alloy. Cast posts-and-cores were luted with zinc phosphate cement, and the core-finishing procedures were applied according to the groups. The tensile tests were performed at a crosshead speed of 0.5 mm/min for all groups, 24 hours after the core-finishing procedures. The data were subjected to one-way analysis of variance (ANOVA and Tukey's test (α = 0.05. No significant differences were observed in the tensile strengths between the control and experimental groups, regardless of the time interval that elapsed between the luting and finishing steps. Within the limitations of the present study, it was demonstrated that the core-finishing procedures and time intervals that elapsed after luting did not appear to affect the retention of cast posts-and-cores when zinc phosphate cement was used.

Core flow control system for field applications; Sistema de controle de core-flow

Energy Technology Data Exchange (ETDEWEB)

Granzotto, Desiree G.; Adachi, Vanessa Y.; Bannwart, Antonio C.; Moura, Luiz F.M. [Universidade Estadual de Campinas (UNICAMP), SP (Brazil); Sassim, Natache S.D.A. [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Centro de Estudo do Petroleo (CEPETRO); Carvalho, Carlos H.M. [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil)

2008-07-01

The significant heavy oil reserves worldwide and the presently high crude oil prices make it essential the development of technologies for heavy oil production and transportation. Heavy oils, with their inherent features of high viscosity (100- 10,000 cP) and density (below 20 deg API) require specific techniques to make it viable their flow in pipes at high flow rates. One of the simplest methods, which do not require use of heat or diluents, is provided by oil-water annular flow (core-flow). Among the still unsolved issues regarding core-flow is the two-phase flow control in order to avoid abrupt increases in the pressure drop due to the possible occurrence of bad water-lubricated points, and thus obtain a safe operation of the line at the lowest possible water-oil ratio. This work presents results of core flow tests which allow designing a control system for the inlet pressure of the line, by actuating on the water flow rate at a fixed oil flow rate. With the circuit model and the specified controller, simulations can be done to assess its performance. The experiments were run at core-flow circuit of LABPETRO-UNICAMP. (author)