Sample records for biological knowledge base

  1. RegenBase: a knowledge base of spinal cord injury biology for translational research.

    Callahan, Alison; Abeyruwan, Saminda W; Al-Ali, Hassan; Sakurai, Kunie; Ferguson, Adam R; Popovich, Phillip G; Shah, Nigam H; Visser, Ubbo; Bixby, John L; Lemmon, Vance P


    Spinal cord injury (SCI) research is a data-rich field that aims to identify the biological mechanisms resulting in loss of function and mobility after SCI, as well as develop therapies that promote recovery after injury. SCI experimental methods, data and domain knowledge are locked in the largely unstructured text of scientific publications, making large scale integration with existing bioinformatics resources and subsequent analysis infeasible. The lack of standard reporting for experiment variables and results also makes experiment replicability a significant challenge. To address these challenges, we have developed RegenBase, a knowledge base of SCI biology. RegenBase integrates curated literature-sourced facts and experimental details, raw assay data profiling the effect of compounds on enzyme activity and cell growth, and structured SCI domain knowledge in the form of the first ontology for SCI, using Semantic Web representation languages and frameworks. RegenBase uses consistent identifier schemes and data representations that enable automated linking among RegenBase statements and also to other biological databases and electronic resources. By querying RegenBase, we have identified novel biological hypotheses linking the effects of perturbagens to observed behavioral outcomes after SCI. RegenBase is publicly available for browsing, querying and download.Database URL: PMID:27055827

  2. A Knowledge Base for Teaching Biology Situated in the Context of Genetic Testing

    van der Zande, Paul; Waarlo, Arend Jan; Brekelmans, Mieke; Akkerman, Sanne F.; Vermunt, Jan D.


    Recent developments in the field of genomics will impact the daily practice of biology teachers who teach genetics in secondary education. This study reports on the first results of a research project aimed at enhancing biology teacher knowledge for teaching genetics in the context of genetic testing. The increasing body of scientific knowledge concerning genetic testing and the related consequences for decision-making indicate the societal relevance of such a situated learning approach. What content knowledge do biology teachers need for teaching genetics in the personal health context of genetic testing? This study describes the required content knowledge by exploring the educational practice and clinical genetic practices. Nine experienced teachers and 12 respondents representing the clinical genetic practices (clients, medical professionals, and medical ethicists) were interviewed about the biological concepts and ethical, legal, and social aspects (ELSA) of testing they considered relevant to empowering students as future health care clients. The ELSA suggested by the respondents were complemented by suggestions found in the literature on genetic counselling. The findings revealed that the required teacher knowledge consists of multiple layers that are embedded in specific genetic test situations: on the one hand, the knowledge of concepts represented by the curricular framework and some additional concepts (e.g. multifactorial and polygenic disorder) and, on the other hand, more knowledge of ELSA and generic characteristics of genetic test practice (uncertainty, complexity, probability, and morality). Suggestions regarding how to translate these characteristics, concepts, and ELSA into context-based genetics education are discussed.

  3. BOWiki: an ontology-based wiki for annotation of data and integration of knowledge in biology

    Gregorio Sergio E


    Full Text Available Abstract Motivation Ontology development and the annotation of biological data using ontologies are time-consuming exercises that currently require input from expert curators. Open, collaborative platforms for biological data annotation enable the wider scientific community to become involved in developing and maintaining such resources. However, this openness raises concerns regarding the quality and correctness of the information added to these knowledge bases. The combination of a collaborative web-based platform with logic-based approaches and Semantic Web technology can be used to address some of these challenges and concerns. Results We have developed the BOWiki, a web-based system that includes a biological core ontology. The core ontology provides background knowledge about biological types and relations. Against this background, an automated reasoner assesses the consistency of new information added to the knowledge base. The system provides a platform for research communities to integrate information and annotate data collaboratively. Availability The BOWiki and supplementary material is available at The source code is available under the GNU GPL from

  4. RegenBase: a knowledge base of spinal cord injury biology for translational research

    Callahan, Alison; Abeyruwan, Saminda W.; Al-Ali, Hassan; Sakurai, Kunie; Ferguson, Adam R.; Popovich, Phillip G.; Shah, Nigam H.; Visser, Ubbo; John L Bixby; Lemmon, Vance P.


    Spinal cord injury (SCI) research is a data-rich field that aims to identify the biological mechanisms resulting in loss of function and mobility after SCI, as well as develop therapies that promote recovery after injury. SCI experimental methods, data and domain knowledge are locked in the largely unstructured text of scientific publications, making large scale integration with existing bioinformatics resources and subsequent analysis infeasible. The lack of standard reporting for experiment...

  5. Integrating biological knowledge based on functional annotations for biclustering of gene expression data.

    Nepomuceno, Juan A; Troncoso, Alicia; Nepomuceno-Chamorro, Isabel A; Aguilar-Ruiz, Jesús S


    Gene expression data analysis is based on the assumption that co-expressed genes imply co-regulated genes. This assumption is being reformulated because the co-expression of a group of genes may be the result of an independent activation with respect to the same experimental condition and not due to the same regulatory regime. For this reason, traditional techniques are recently being improved with the use of prior biological knowledge from open-access repositories together with gene expression data. Biclustering is an unsupervised machine learning technique that searches patterns in gene expression data matrices. A scatter search-based biclustering algorithm that integrates biological information is proposed in this paper. In addition to the gene expression data matrix, the input of the algorithm is only a direct annotation file that relates each gene to a set of terms from a biological repository where genes are annotated. Two different biological measures, FracGO and SimNTO, are proposed to integrate this information by means of its addition to-be-optimized fitness function in the scatter search scheme. The measure FracGO is based on the biological enrichment and SimNTO is based on the overlapping among GO annotations of pairs of genes. Experimental results evaluate the proposed algorithm for two datasets and show the algorithm performs better when biological knowledge is integrated. Moreover, the analysis and comparison between the two different biological measures is presented and it is concluded that the differences depend on both the data source and how the annotation file has been built in the case GO is used. It is also shown that the proposed algorithm obtains a greater number of enriched biclusters than other classical biclustering algorithms typically used as benchmark and an analysis of the overlapping among biclusters reveals that the biclusters obtained present a low overlapping. The proposed methodology is a general-purpose algorithm which allows

  6. A knowledge base for teaching biology situated in the context of genetic testing

    van der Zande, P.A.M.; Waarlo, A.J.; Brekelmans, M.; Akkerman, S.F.; Vermunt, J. D.


    Recent developments in the field of genomics will impact the daily practice of biology teachers who teach genetics in secondary education. This study reports on the first results of a research project aimed at enhancing biology teacher knowledge for teaching genetics in the context of genetic testin

  7. A Knowledge Base for Teaching Biology Situated in the Context of Genetic Testing

    van der Zande, Paul; Waarlo, Arend Jan; Brekelmans, Mieke; Akkerman, Sanne F.; Vermunt, Jan D.


    Recent developments in the field of genomics will impact the daily practice of biology teachers who teach genetics in secondary education. This study reports on the first results of a research project aimed at enhancing biology teacher knowledge for teaching genetics in the context of genetic testing. The increasing body of scientific knowledge…

  8. [A novel biological pathway expansion method based on the knowledge of protein-protein interactions].

    Zhao, Xiaolei; Zuo, Xiaoyu; Qin, Jiheng; Liang, Yan; Zhang, Naizun; Luan, Yizhao; Rao, Shaoqi


    Biological pathways have been widely used in gene function studies; however, the current knowledge for biological pathways is per se incomplete and has to be further expanded. Bioinformatics prediction provides us a cheap but effective way for pathway expansion. Here, we proposed a novel method for biological pathway prediction, by intergrating prior knowledge of protein?protein interactions and Gene Ontology (GO) database. First, the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways to which the interacting neighbors of a targe gene (at the level of protein?protein interaction) belong were chosen as the candidate pathways. Then, the pathways to which the target gene belong were determined by testing whether the genes in the candidate pathways were enriched in the GO terms to which the target gene were annotated. The protein?protein interaction data obtained from the Human Protein Reference Database (HPRD) and Biological General Repository for Interaction Datasets (BioGRID) were respectively used to predict the pathway attribution(s) of the target gene. The results demanstrated that both the average accuracy (the ratio of the correctly predicted pathways to the totally pathways to which all the target genes were annotated) and the relative accuracy (of the genes with at least one annotated pathway being successful predicted, the percentage of the genes with all the annotated pathways being correctly predicted) for pathway predictions were increased with the number of the interacting neighbours. When the number of interacting neighbours reached 22, the average accuracy was 96.2% (HPRD) and 96.3% (BioGRID), respectively, and the relative accuracy was 93.3% (HPRD) and 84.1% (BioGRID), respectively. Further validation analysis of 89 genes whose pathway knowledge was updated in a new database release indicated that 50 genes were correctly predicted for at least one updated pathway, and 43 genes were accurately predicted for all the updated pathways, giving an

  9. Conceptual Model-based Systems Biology: mapping knowledge and discovering gaps in the mRNA transcription cycle.

    Judith Somekh


    Full Text Available We propose a Conceptual Model-based Systems Biology framework for qualitative modeling, executing, and eliciting knowledge gaps in molecular biology systems. The framework is an adaptation of Object-Process Methodology (OPM, a graphical and textual executable modeling language. OPM enables concurrent representation of the system's structure-the objects that comprise the system, and behavior-how processes transform objects over time. Applying a top-down approach of recursively zooming into processes, we model a case in point-the mRNA transcription cycle. Starting with this high level cell function, we model increasingly detailed processes along with participating objects. Our modeling approach is capable of modeling molecular processes such as complex formation, localization and trafficking, molecular binding, enzymatic stimulation, and environmental intervention. At the lowest level, similar to the Gene Ontology, all biological processes boil down to three basic molecular functions: catalysis, binding/dissociation, and transporting. During modeling and execution of the mRNA transcription model, we discovered knowledge gaps, which we present and classify into various types. We also show how model execution enhances a coherent model construction. Identification and pinpointing knowledge gaps is an important feature of the framework, as it suggests where research should focus and whether conjectures about uncertain mechanisms fit into the already verified model.

  10. Knowledge Based Strategies for Knowledge Based Organizations

    Madalina Cristina Tocan


    Full Text Available In the present, we can observe that a new economy is arising. It is an economy based on knowledge and ideas, in which the key factor for prosperity and for creation of the new jobs is the knowledge capitalization. Knowledge capitalization, intellectual capital, obtaining prosperity in the market economy imposes a new terminology, new managerial methods and techniques, new technologies and also new strategies. In other words, knowledge based economy, as a new type of economy; impose a new type of management- knowledge based management and a new type of enterprise-knowledge based enterprise.Taking in consideration these predictable evolutions, this paper will try to present: • The main ideas of the researches the field of the knowledge based economy • The characteristics and principles of the knowledge based organizations and knowledge based management • The challenges and opportunities for knowledge based organizations.The first part of the paper will present the principles of the new economy- knowledge base economy, the essential and interrelated elements necessary to build and to implement a strategy in a knowledge economy and the opportunities and challenges to the countries as they seek to build regionally and globally competitive knowledge-based economies.The second part of the paper will present the characteristics of the knowledge based organizations, the principles and characteristics of their management. For many organizations, knowledge management is a relatively new concept, because they are discovering the knowledge value in their operations. Many firms have undertaken formal and informal knowledge management initiatives designed to improve process performance, increase customer responsiveness and spur innovation. But while some organizations have reaped significant benefits from their investment in knowledge efforts, others have run into noteworthy challenges.

  11. Knowledge Based Strategies for Knowledge Based Organizations

    Madalina Cristina Tocan


    In the present, we can observe that a new economy is arising. It is an economy based on knowledge and ideas, in which the key factor for prosperity and for creation of the new jobs is the knowledge capitalization. Knowledge capitalization, intellectual capital, obtaining prosperity in the market economy imposes a new terminology, new managerial methods and techniques, new technologies and also new strategies. In other words, knowledge based economy, as a new type of economy; impose a new type...

  12. Chapter 8: Biological knowledge assembly and interpretation.

    Ju Han Kim

    Full Text Available Most methods for large-scale gene expression microarray and RNA-Seq data analysis are designed to determine the lists of genes or gene products that show distinct patterns and/or significant differences. The most challenging and rate-liming step, however, is to determine what the resulting lists of genes and/or transcripts biologically mean. Biomedical ontology and pathway-based functional enrichment analysis is widely used to interpret the functional role of tightly correlated or differentially expressed genes. The groups of genes are assigned to the associated biological annotations using Gene Ontology terms or biological pathways and then tested if they are significantly enriched with the corresponding annotations. Unlike previous approaches, Gene Set Enrichment Analysis takes quite the reverse approach by using pre-defined gene sets. Differential co-expression analysis determines the degree of co-expression difference of paired gene sets across different conditions. Outcomes in DNA microarray and RNA-Seq data can be transformed into the graphical structure that represents biological semantics. A number of biomedical annotation and external repositories including clinical resources can be systematically integrated by biological semantics within the framework of concept lattice analysis. This array of methods for biological knowledge assembly and interpretation has been developed during the past decade and clearly improved our biological understanding of large-scale genomic data from the high-throughput technologies.

  13. Knowledge Based Economy Assessment

    Madalina Cristina Tocan


    The importance of knowledge-based economy (KBE) in the XXI century is evident. In the article the reflection of knowledge on economy is analyzed. The main point is targeted to the analysis of characteristics of knowledge expression in economy and to the construction of structure of KBE expression. This allows understanding the mechanism of functioning of knowledge economy. The authors highlight the possibility to assess the penetration level of KBE which could manifest itself trough the exist...

  14. Monitoring Knowledge Base (MKB)

    U.S. Environmental Protection Agency — The Monitoring Knowledge Base (MKB) is a compilation of emissions measurement and monitoring techniques associated with air pollution control devices, industrial...

  15. Guarded Hybrid Knowledge Bases

    Heymans, Stijn; Predoiu, Livia; Feier, Cristina; Van Nieuwenborgh, Davy


    Recently, there has been a lot of interest in the integration of Description Logics and rules on the Semantic Web.We define guarded hybrid knowledge bases (or g-hybrid knowledge bases) as knowledge bases that consist of a Description Logic knowledge base and a guarded logic program, similar to the DL+log knowledge bases from (Rosati 2006). G-hybrid knowledge bases enable an integration of Description Logics and Logic Programming where, unlike in other approaches, variables in the rules of a guarded program do not need to appear in positive non-DL atoms of the body, i.e. DL atoms can act as guards as well. Decidability of satisfiability checking of g-hybrid knowledge bases is shown for the particular DL DLRO, which is close to OWL DL, by a reduction to guarded programs under the open answer set semantics. Moreover, we show 2-EXPTIME-completeness for satisfiability checking of such g-hybrid knowledge bases. Finally, we discuss advantages and disadvantages of our approach compared with DL+log knowledge bases.

  16. Indigenous Knowledge, Ecology, and Evolutionary Biology

    E. N. Anderson


    Review of Indigenous Knowledge, Ecology, and Evolutionary Biology. Raymond Pierotti. 2011. Routledge (Taylor & Francis Group), New York.  Pp. Xv + 264, Bibliography, index.  ISBN13: 978-0-415-87924-8 (hbk), 978-0-203-84711-4 (ebk).

  17. Knowledge Based Economy Assessment

    Madalina Cristina Tocan


    Full Text Available The importance of knowledge-based economy (KBE in the XXI century isevident. In the article the reflection of knowledge on economy is analyzed. The main point is targeted to the analysis of characteristics of knowledge expression in economy and to the construction of structure of KBE expression. This allows understanding the mechanism of functioning of knowledge economy. Theauthors highlight the possibility to assess the penetration level of KBE which could manifest itself trough the existence of products of knowledge expression which could be created in acquisition, creation, usage and development of them. The latter phenomenon is interpreted as knowledge expression characteristics: economic and social context, human resources, ICT, innovative business and innovation policy. The reason for this analysis was based on the idea that in spite of the knowledge economy existence in all developed World countries adefinitive, universal list of indicators for mapping and measuring the KBE does not yet exists. Knowledge Expression Assessment Models are presented in the article.


    Lupsa Dana; Constantin Sanda


    For the past years, information and knowledge are replacing capital and energy as the primary wealth-creating assets, generating a new type of economy, and called knowledge based economy (KBE), within knowledge management is the main instrument for the companies to obtain competitive advantage. Given the goal of EU established at Lisbon and the perspective of Romania’s accession to EU, Romanian companies must align their management practices with knowledge management in order to survive on a ...

  19. TF-finder: A software package for identifying transcription factors involved in biological processes using microarray data and existing knowledge base

    Cui Xiaoqi


    Full Text Available Abstract Background Identification of transcription factors (TFs involved in a biological process is the first step towards a better understanding of the underlying regulatory mechanisms. However, due to the involvement of a large number of genes and complicated interactions in a gene regulatory network (GRN, identification of the TFs involved in a biology process remains to be very challenging. In reality, the recognition of TFs for a given a biological process can be further complicated by the fact that most eukaryotic genomes encode thousands of TFs, which are organized in gene families of various sizes and in many cases with poor sequence conservation except for small conserved domains. This poses a significant challenge for identification of the exact TFs involved or ranking the importance of a set of TFs to a process of interest. Therefore, new methods for recognizing novel TFs are desperately needed. Although a plethora of methods have been developed to infer regulatory genes using microarray data, it is still rare to find the methods that use existing knowledge base in particular the validated genes known to be involved in a process to bait/guide discovery of novel TFs. Such methods can replace the sometimes-arbitrary process of selection of candidate genes for experimental validation and significantly advance our knowledge and understanding of the regulation of a process. Results We developed an automated software package called TF-finder for recognizing TFs involved in a biological process using microarray data and existing knowledge base. TF-finder contains two components, adaptive sparse canonical correlation analysis (ASCCA and enrichment test, for TF recognition. ASCCA uses positive target genes to bait TFS from gene expression data while enrichment test examines the presence of positive TFs in the outcomes from ASCCA. Using microarray data from salt and water stress experiments, we showed TF-finder is very efficient in recognizing

  20. Knowledge-based utility

    This presentation provides industry examples of successful marketing practices by companies facing deregulation and competition. The common thread through the examples is that long term survival of today's utility structure is dependent on the strategic role of knowledge. As opposed to regulated monopolies which usually own huge physical assets and have very little intelligence about their customers, unregulated enterprises tend to be knowledge-based, characterized by higher market value than book value. A knowledge-based enterprise gathers data, creates information and develops knowledge by leveraging it as a competitive weapon. It institutionalizes human knowledge as a corporate asset for use over and over again by the use of databases, computer networks, patents, billing, collection and customer services (BCCS), branded interfaces and management capabilities. Activities to become knowledge-based such as replacing inventory/fixed assets with information about material usage to reduce expenditure and achieve more efficient operations, and by focusing on integration and value-adding delivery capabilities, were reviewed

  1. One knowledge base or many knowledge pools?

    Lundvall, Bengt-Åke

    there is one common knowledge base on which economic activities can be built. In this paper we argue that it is more appropriate to see the economy as connecting to different ‘pools of knowledge'. The argument is built upon a conceptual framework where we make distinctions between private/public, local....../global, individual/collective and tacit/codified knowledge. The purpose is both ‘academic' and practical. Our analysis demonstrates the limits of a narrowly economic perspective on knowledge and we show that these distinctions have important implications both for innovation policy and for management of innovation.......It is increasingly realized that knowledge is the most important resource and that learning is the most important process in the economy. Sometimes this is expressed by coining the current era as characterised by a ‘knowledge based economy'. But this concept might be misleading by indicating that...

  2. Knowledge based maintenance

    Sturm, A. [Hamburgische Electacitaets-Werke AG Hamburg (Germany)


    The establishment of maintenance strategies is of crucial significance for the reliability of a plant and the economic efficiency of maintenance measures. Knowledge about the condition of components and plants from the technical and business management point of view therefore becomes one of the fundamental questions and the key to efficient management and maintenance. A new way to determine the maintenance strategy can be called: Knowledge Based Maintenance. A simple method for determining strategies while taking the technical condition of the components of the production process into account to the greatest possible degree which can be shown. A software with an algorithm for Knowledge Based Maintenance leads the user during complex work to the determination of maintenance strategies for this complex plant components. (orig.)

  3. Extracted knowledge interpretation in mining biological data: A survey

    Ricardo Martine; Martine Collard


    This paper discusses different approaches for integrating biological knowledge in gene expression analysis. Indeed we are interested in the fifth step of microarray analysis procedure which focuses on knowledge discovery via interpretation of the microarray results. We present a state of the art of methods for processing this step and we propose a classification in three facets: prior or knowledge-based, standard or expression-based and co-clustering. First we discuss briefly the purpose and use...

  4. Using student motivation to design groups in a non-majors biology course for team-based collaborative learning: Impacts on knowledge, views, attitudes, and perceptions

    Walters, Kristi L.

    The importance of student motivation and its connection to other learning variables (i.e., attitudes, knowledge, persistence, attendance) is well established. Collaborative work at the undergraduate level has been recognized as a valuable tool in large courses. However, motivation and collaborative group work have rarely been combined. This project utilized student motivation to learn biology to place non-major biology undergraduates in collaborative learning groups at East Carolina University, a mid-sized southeastern American university, to determine the effects of this construct on student learning. A pre-test measuring motivation to learn biology, attitudes toward biology, perceptions of biology and biologists, views of science, and content knowledge was administered. A similar post-test followed as part of the final exam. Two sections of the same introductory biology course (n = 312) were used and students were divided into homogeneous and heterogeneous groups (based on their motivation score). The heterogeneous groups (n = 32) consisted of a mixture of different motivation levels, while the homogeneous groups (n = 32) were organized into teams with similar motivation scores using tiers of high-, middle-, and low-level participants. Data analysis determined mixed perceptions of biology and biologists. These include the perceptions biology was less intriguing, less relevant, less practical, less ethical, and less understandable. Biologists were perceived as being neat and slightly intelligent, but not very altruistic, humane, ethical, logical, honest, or moral. Content knowledge scores more than doubled from pre- to post-test. Half of the items measuring views of science were not statistically significantly different from pre- to post-test. Many of the factors for attitudes toward biology became more agreeable from pre- to post-test. Correlations between motivation scores, participation levels, attendance rates, and final course grades were examined at both the

  5. Onlincolnshire Knowledge Base Collaboration

    Fuller, Ted; Bosworth, Gary; Deville, Jane


    This report outlines the Onlincolnshire Knowledge Base Collaboration project undertaken by Lincoln Business School between May 2014 and September 2015. Onlincolnshire is a Lincolnshire County Council-run project which is part-funded by the East Midlands European Regional Development Fund (ERDF) Programme 2007 to 2013. As well as improving the broadband infrastructure, Onlincolnshire delivered a range of support to Lincolnshire’s Small and Medium Sized Enterprises (SMEs) through the “Business...

  6. Web based foundry knowledge base

    A. Stawowy


    Full Text Available The main assumptions and functions of proposed Foundry Knowledge Base (FKB are presented in this paper. FKB is a framework forinformation exchange of casting products and manufacturing methods. We use CMS (Content Management System to develope andmaintain our web-based system. The CastML – XML dialect developed by authors for description of casting products and processes – isused as a tool for information interchange between ours and outside systems, while SQL is used to store and edit knowledge rules and alsoto solve the basic selection problems in the rule-based module. Besides the standard functions (companies data, news, events, forums and media kit, our website contains a number of nonstandard functions; the intelligent search module based on expert system is the main advantage of our solution. FKB is to be a social portal which content will be developed by foundry community.

  7. On Knowledge Excavation Based on University Library Knowledge Base

    Ying Song


    Knowledge excavation is a new information processing technology. Nowadays, knowledge excavation has been widely applied to the university library management. Knowledge excavation in university library knowledge bases has already been playing an important role in improving the management of university libraries and inevitably will play a more profound role in the future. In this paper, the meaning of knowledge excavation in university library knowledge bases and other related issues are studie...

  8. The knowledge base of journalism

    Svith, Flemming

    theories on practice and knowledge. As the result of an abductive reasoning is a theory proposal, there is a need for more deductive approaches to test the validity of this knowledge base claim. It is thus relevant to investigate which rationales are included in the knowledge base of journalism, as the...

  9. Knowledge Management Based on ERP

    Qian Feng; Yuanyuan Huang


    In an information explosive era, knowledge management has become a hot field in enterprise informatization. In order to adapt to the competitive environment, it is now an urgent task to add knowledge management to ERP system and integrate learning and innovation on the platform of enterprise information system based on ERP. This paper focuses on knowledge management based on ERP and introduces a knowledge management system: KRM.

  10. Knowledge-based Telecom Industry

    Vinje, Villeman; Nordkvelde, Marius


    BI Norwegian School of Management is conducting a national research project entitled “A knowledge-based Norway”. Thirteen major knowledge-based industries in Norway are being analyzed under the auspices of the project. This study assesses the underlying properties of a global knowledge hub to examine the extent to which the Norwegian telecom industry – which encompasses all telecom firms located in Norway regardless of ownership – constitutes a global knowledge hub. It commences with a ge...

  11. Foundation: Transforming data bases into knowledge bases

    Purves, R. B.; Carnes, James R.; Cutts, Dannie E.


    One approach to transforming information stored in relational data bases into knowledge based representations and back again is described. This system, called Foundation, allows knowledge bases to take advantage of vast amounts of pre-existing data. A benefit of this approach is inspection, and even population, of data bases through an intelligent knowledge-based front-end.

  12. Knowledge Based Health

    Sasson, Amir


    In this study, we assess the underlying properties of a global knowledge hub to examine the extent to which the Norwegian health industry constitutes such a hub. We begin with a general discussion of the industry before we examine the underlying properties of global knowledge hubs: cluster attractiveness, educational attractiveness, talent attractiveness, R&D and innovation attractiveness, ownership attractiveness, environmental attractiveness and cluster dynamics. We conclude by providing cl...

  13. The Effect of Knowledge Linking Levels in Biology Lessons upon Students' Knowledge Structure

    Wadouh, Julia; Liu, Ning; Sandmann, Angela; Neuhaus, Birgit J.


    Knowledge structure is an important aspect for defining students' competency in biology learning, but how knowledge structure is influenced by the teaching process in naturalistic biology classroom settings has scarcely been empirically investigated. In this study, 49 biology lessons in the teaching unit "blood and circulatory…

  14. In complex biology, prior knowledge is power

    Ideker, Trey; Dutkowski, Janusz; Hood, Leroy


    Complexity is the grand challenge for science and engineering in the 21st century. We suggest that biology is a discipline that is uniquely situated to tackle complexity, through a diverse array of technologies for characterizing molecular structure, interactions and function. A major difficulty in the analysis of complex biological systems is dealing with the low signal-to-noise inherent to nearly all large-scale biological data sets. We discuss powerful bioinformatic concepts for boosting s...

  15. Research on Knowledge Sharing Based on Knowledge Convening & Fermenting Model

    Jiansheng Tang; Jinsheng He


    Despite of the fact that knowledge sharing has become the focus of current literature and management practice,  the core process of knowledge sharing has not been identified. What are the main barriers & incentives for people to share their knowledge, what is the internal mechanism of knowledge sharing, and how people evaluate the benefit coming from knowledge sharing are the core areas in knowledge management .In this paper we reexamine the knowledge sharing based on knowledge convening ...

  16. Shaping Biological Knowledge: Applications in Proteomics

    R. Appel


    Full Text Available The central dogma of molecular biology has provided a meaningful principle for data integration in the field of genomics. In this context, integration reflects the known transitions from a chromosome to a protein sequence: transcription, intron splicing, exon assembly and translation. There is no such clear principle for integrating proteomics data, since the laws governing protein folding and interactivity are not quite understood. In our effort to bring together independent pieces of information relative to proteins in a biologically meaningful way, we assess the bias of bioinformatics resources and consequent approximations in the framework of small-scale studies. We analyse proteomics data while following both a data-driven (focus on proteins smaller than 10 kDa and a hypothesis-driven (focus on whole bacterial proteomes approach. These applications are potentially the source of specialized complements to classical biological ontologies.

  17. The Notion of Scientific Knowledge in Biology

    Morante, Silvia; Rossi, Giancarlo


    The purpose of this work is to reconsider and critically discuss the conceptual foundations of modern biology and bio-sciences in general, and provide an epistemological guideline to help framing the teaching of these disciplines and enhancing the quality of their presentation in High School, Master and Ph.D. courses. After discussing the methodological problems that arise in trying to construct a sensible and useful scientific approach applicable to the study of living systems, we illustrate what are the general requirements that a workable scheme of investigation should meet to comply with the principles of the Galilean method. The amazing success of basic physics, the Galilean science of election, can be traced back to the development of a radically " reductionistic" approach in the interpretation of experiments and a systematic procedure tailored on the paradigm of " falsifiability" aimed at consistently incorporating new information into extended models/theories. The development of bio-sciences seems to fit with neither reductionism (the deeper is the level of description of a biological phenomenon the more difficult looks finding general and simple laws), nor falsifiability (not always experiments provide a yes-or-no answer). Should we conclude that biology is not a science in the Galilean sense? We want to show that this is not so. Rather in the study of living systems, the novel interpretative paradigm of " complexity" has been developed that, without ever conflicting with the basic principles of physics, allows organizing ideas, conceiving new models and understanding the puzzling lack of reproducibility that seems to affect experiments in biology and in other modern areas of investigation. In the delicate task of conveying scientific concepts and principles to students as well as in popularising bio-sciences to a wider audience, it is of the utmost importance for the success of the process of learning to highlight the internal logical consistency of

  18. The Knowledge Based Information Economy

    Eliasson, Gunnar; Fölster, Stefan; Lindberg, Thomas; Pousette, Tomas; Erol TAYMAZ


    Working Paper No. 256 is published as "The Knowledge Based Information Economy" (authors: Gunnar Eliasson, Stefan Fölster, Thomas Lindberg, Tomas Pousette and Erol Taymaz). Stockholm: Industrial Institute for Economic and Social Research and Telecon, 1990.


    Dragos CRISTEA


    Full Text Available This paper tries to present the existent relation between knowledge society and knowledge based economy. We will identify the main pillars of knowledge society and present their importance for the development of knowledge societies. Further, we will present two perspectives over knowledge societies, respectively science and learning perspectives, that directly affects knowledge based economies. At the end, we will conclude by identifying some important questions that must be answered regarding this new social paradigm.


    Dragos CRISTEA; Matei, Daniela


    This paper tries to present the existent relation between knowledge society and knowledge based economy. We will identify the main pillars of knowledge society and present their importance for the development of knowledge societies. Further, we will present two perspectives over knowledge societies, respectively science and learning perspectives, that directly affects knowledge based economies. At the end, we will conclude by identifying some important questions ...

  1. Knowledge-based nursing diagnosis

    Roy, Claudette; Hay, D. Robert


    Nursing diagnosis is an integral part of the nursing process and determines the interventions leading to outcomes for which the nurse is accountable. Diagnoses under the time constraints of modern nursing can benefit from a computer assist. A knowledge-based engineering approach was developed to address these problems. A number of problems were addressed during system design to make the system practical extended beyond capture of knowledge. The issues involved in implementing a professional knowledge base in a clinical setting are discussed. System functions, structure, interfaces, health care environment, and terminology and taxonomy are discussed. An integrated system concept from assessment through intervention and evaluation is outlined.

  2. Visualising Knowledge Structures in Biology: Discipline, Curriculum and Student Understanding

    Kinchin, Ian M.


    Concept mapping is discussed as a tool for the visualisation of knowledge structures that can be exploited within biological education. Application of this tool makes it possible to relate the structure of the curriculum to the structure of the discipline, in order to support the development of robust student knowledge structures in ways that…

  3. ERB - Graphic knowledge base editor

    The paper describes the present state and future prospects of the Expert System for Operator Support (ESOS) developed at the Nuclear Research Institute at Rez near Prague (NRI). Special emphasis is put on knowledge acquisition and knowledge base representation means - ERB. ERB is a package of programs, which enables the user to create, edit and compile a knowledge base of the Expert System RECON, to create and edit testing data and to test knowledge base (KB). The knowledge base is displayed in the form of a graph, where nodes represent the rules and arcs represent the relations ''PREDECESSOR→SUCCESSOR''. The filling of KB is integrated with the design of their graphical representation. Owing to this, the form of the KB representation makes the whole KB more understandable. The filling process of KB corresponds with general methodologies, where in the first step nodes with identifiers and texts are defined, in the second step relations between them are specified, in the third step the predecessor is defined and finally, relations between nodes are concretized. The paper contains a description of the functions offered by the ERB. (author). 2 refs, 5 figs

  4. A dynamic knowledge base based search engine

    WANG Hui-jin; HU Hua; LI Qing


    Search engines have greatly helped us to find thedesired information from the Intemet. Most search engines use keywords matching technique. This paper discusses a Dynamic Knowledge Base based Search Engine (DKBSE), which can expand the user's query using the keywords' concept or meaning. To do this, the DKBSE needs to construct and maintain the knowledge base dynamically via the system's searching results and the user's feedback information. The DKBSE expands the user's initial query using the knowledge base, and returns the searched information after the expanded query.

  5. Reusing Design Knowledge Based on Design Cases and Knowledge Map

    Yang, Cheng; Liu, Zheng; Wang, Haobai; Shen, Jiaoqi


    Design knowledge was reused for innovative design work to support designers with product design knowledge and help designers who lack rich experiences to improve their design capacity and efficiency. First, based on the ontological model of product design knowledge constructed by taxonomy, implicit and explicit knowledge was extracted from some…

  6. Role of Knowledge Based Communities in Knowledge Process

    Sebastian Ion CEPTUREANU; Eduard Gabriel CEPTUREANU


    In the new economy, knowledge is an essential component of economic and social systems. The organizational focus has to be on building knowledge-based management, development of human resource and building intellectual capital capabilities. Knowledge-based management is defined, at company level, by economic processes that emphasize creation, selling, buying, learning, storing, developing, sharing and protection of knowledge as a decisive condition for profit and long-term sustainability of t...

  7. Role of Knowledge Based Communities in Knowledge Process

    Sebastian Ion CEPTUREANU


    Full Text Available In the new economy, knowledge is an essential component of economic and social systems. The organizational focus has to be on building knowledge-based management, development of human resource and building intellectual capital capabilities. Knowledge-based management is defined, at company level, by economic processes that emphasize creation, selling, buying, learning, storing, developing, sharing and protection of knowledge as a decisive condition for profit and long-term sustainability of the company. Hence, knowledge is, concurently, according to a majoritiy of specialists, raw material, capital, product and an essential input. Knowledge-based communities are one of the main constituent elements of a framework for knowledge based management. These are peer networks consisting of practitioners within an organization, supporting each other to perform better through the exchange and sharing of knowledge. Some large companies have contributed or supported the establishment of numerous communities of practice, some of which may have several thousand members. They operate in different ways, are of different sizes, have different areas of interest and addresses knowledge at different levels of its maturity. This article examines the role of knowledge-based communities from the perspective of knowledge based management, given that the arrangements for organizational learning, creating, sharing, use of knowledge within organizations become more heterogeneous and take forms more difficult to predict by managers and specialists.

  8. Integrating heterogeneous knowledges for understanding biological behaviors: a probabilistic approach

    Bourdon, Jérémie; Eveillard, Damien; Gabillard, Samuel; Merle, Theo


    Despite recent molecular technique improvements, biological knowledge remains incomplete. Reasoning on living systems hence implies to integrate heterogeneous and partial informations. Although current investigations successfully focus on qualitative behaviors of macromolecular networks, others approaches show partial quantitative informations like protein concentration variations over times. We consider that both informations, qualitative and quantitative, have to be combined into a modeling...

  9. Design of Multi-attribute Knowledge Base Based on Hybrid Knowledge Representation

    TANG Zhi-jie; YANG Bao-an; ZHANG Ke-jing


    Based on the knowledge representation and knowledge reasoning, this paper addresses the creation of the multiattribute knowledge base on the basis of hybrid knowledge representation, with the help of object-oriented programming language and relational database. Compared with general knowledge base, multi-attribute knowledge base can enhance the ability of knowledge processing and application;integrate the heterogeneous knowledge, such as model,symbol, case-based sample knowledge; and support the whole decision process by integrated reasoning.

  10. Student Perceived and Determined Knowledge of Biology Concepts in an Upper-Level Biology Course

    Ziegler, Brittany; Montplaisir, Lisa


    Students who lack metacognitive skills can struggle with the learning process. To be effective learners, students should recognize what they know and what they do not know. This study examines the relationship between students' perception of their knowledge and determined knowledge in an upper-level biology course utilizing a pre/posttest…

  11. Knowledge-based tracking algorithm

    Corbeil, Allan F.; Hawkins, Linda J.; Gilgallon, Paul F.


    This paper describes the Knowledge-Based Tracking (KBT) algorithm for which a real-time flight test demonstration was recently conducted at Rome Air Development Center (RADC). In KBT processing, the radar signal in each resolution cell is thresholded at a lower than normal setting to detect low RCS targets. This lower threshold produces a larger than normal false alarm rate. Therefore, additional signal processing including spectral filtering, CFAR and knowledge-based acceptance testing are performed to eliminate some of the false alarms. TSC's knowledge-based Track-Before-Detect (TBD) algorithm is then applied to the data from each azimuth sector to detect target tracks. In this algorithm, tentative track templates are formed for each threshold crossing and knowledge-based association rules are applied to the range, Doppler, and azimuth measurements from successive scans. Lastly, an M-association out of N-scan rule is used to declare a detection. This scan-to-scan integration enhances the probability of target detection while maintaining an acceptably low output false alarm rate. For a real-time demonstration of the KBT algorithm, the L-band radar in the Surveillance Laboratory (SL) at RADC was used to illuminate a small Cessna 310 test aircraft. The received radar signal wa digitized and processed by a ST-100 Array Processor and VAX computer network in the lab. The ST-100 performed all of the radar signal processing functions, including Moving Target Indicator (MTI) pulse cancelling, FFT Doppler filtering, and CFAR detection. The VAX computers performed the remaining range-Doppler clustering, beamsplitting and TBD processing functions. The KBT algorithm provided a 9.5 dB improvement relative to single scan performance with a nominal real time delay of less than one second between illumination and display.

  12. Active Knowledge: Dynamically Enriching RDF Knowledge Bases by Web Services

    Nicoleta Preda; Gjergji Kasneci; Fabian Suchanek; Thomas Neumann; Wenjun Yuan; Gerhard Weikum. Active Knowledge


    The proliferation of knowledge-sharing communities and the advances in information extraction have enabled the construction of large knowledge bases using the RDF data model to represent entities and relationships. However, as the Web and its latently embedded facts evolve, a knowledge base can never be complete and up-to-date. On the other hand, a rapidly increasing suite of Web services provide access to timely and high-quality information, but this is encapsulated by the service interface....


    Minja Zorc


    Full Text Available Systems biology approaches being applied to animal breeding represent an opportunity to derive greater benefits from animal production systems. The increasingly detailed investigations in systems biology have led to a large amount of data dispersed over various sources; therefore, a centralized knowledge base is in demand. In this study, we have integrated cattle genomics data of heterogeneous sources and types and developed a bioinformatics tool to study genotype-phenotype associations in cattle: The tool enables revealing genomic overlaps within trait-associated loci and identification of potential functional candidates. It might be also used as a tool for planning genotype– phenotype research in cattle.

  14. A Property Restriction Based Knowledge Merging Method

    Che, Haiyan; Chen, Wei; Feng, Tie; Zhang, Jiachen

    Merging new instance knowledge extracted from the Web according to certain domain ontology into the knowledge base (KB for short) is essential for the knowledge management and should be processed carefully, since this may introduce redundant or contradictory knowledge, and the quality of the knowledge in the KB, which is very important for a knowledge-based system to provide users high quality services, will suffer from such "bad" knowledge. Advocates a property restriction based knowledge merging method, it can identify the equivalent instances, redundant or contradictory knowledge according to the property restrictions defined in the domain ontology and can consolidate the knowledge about equivalent instances and discard the redundancy and conflict to keep the KB compact and consistent. This knowledge merging method has been used in a semantic-based search engine project: CRAB and the effect is satisfactory.

  15. The New Economy- Knowledge Based Economy

    Marin, Carmen


    The aim of this paper is to emphasize the importance of knowledge based economy, in this time characterized by fast changes and sometimes radical changes, it is impossible to resist without adapting, both people and the organizations too. The matter of the paper develops knowledge based economy concept: elements, definitions of the knowledge based economy, stages and the main knowledge codification. In the end of the paper, the author presents the importance of economy knowledge, in Romanian ...

  16. Web-Based Knowledge Warehouse Development 2

    Alabed, Asmaa; Chen, Xun


    The aim of the research is to facilitate knowledge management process for grinding technology by building a flexible and easy to use web-based knowledge warehouse (Web-KW), which could manage both explicit and tacit knowledge. The objectives are to design and develop the following modules: • Date Interface (DIM) • Database (DBM) • Problem Solving (PSM) • Learning Knowledge Discovery (LKDM) • Knowledge warehouse (KWM) • Knowledge Analysis (KAM).

  17. Measuring a Society’s Knowledge Base

    Khumalo, Bhekuzulu


    The quest to measure knowledge effectively will in no doubt lead to better knowledge policies of governments around the world in both developing and developed countries. This paper endeavours to seta sound theoretical base for measuring knowledge and does this by demonstrating that existing tools used by economists for measuring knowledge are largely self contradictory, they contradict existing theory. Knowledge to be measured effectively we must give knowledge its own units like weight and l...

  18. Knowledge Base Editor (SharpKBE)

    Tikidjian, Raffi; James, Mark; Mackey, Ryan


    The SharpKBE software provides a graphical user interface environment for domain experts to build and manage knowledge base systems. Knowledge bases can be exported/translated to various target languages automatically, including customizable target languages.

  19. Adaptation Knowledge Discovery from a Case Base

    D'Aquin, Mathieu; Badra, Fadi; Lafrogne, Sandrine; Lieber, Jean; Napoli, Amedeo; Szathmary, Laszlo


    In case-based reasoning, the adaptation step depends in general on domain-dependent knowledge, which motivates studies on adaptation knowledge acquisition (AKA). CABAMAKA is an AKA system based on principles of knowledge discovery from databases. This system explores the variations within the case base to elicit adaptation knowledge. It has been successfully tested in an application of case-based decision support to breast cancer treatment.

  20. Barbers' knowledge and practice about occupational biological hazards was low in Gondar town, North West Ethiopia

    Beyen Teresa Kisi


    Full Text Available Abstract Background Several health hazards including communicable diseases and skin conditions are associated with Barbers’ profession to which their visitors are exposed. Thus, knowledge and practice of Barbers would play a vital part in prevention and control of these health hazards. So, the aim of this study is to assess knowledge and practice, and associated factors among barbers about biological hazards associated with their profession in Gondar town, North West Ethiopia. Methods To assess knowledge and practice, and associated factors among barbers about biological hazards associated with their profession in Gondar town, North West Ethiopia, A work place based cross-sectional study was conducted from March 28 to April 6, 2012. The total numbers of Barbers in the town were 960 of which 400 Barbers were participated in the study. Sample size was determined using the formula for single population proportion by considering, 51% proportion, knowledgeable Barbers from Jimma, Ethiopia, 95% level of confidence, 5% margin of error and 15% none response rate. The numbers of barbers included in the study were selected by using systematic random sampling. Data was collected by face to face interview using a structured and pre-tested questionnaire. Binary and multivariate logistic regression analyses were conducted to identify factors associated with knowledge and practice of barbers. Results Of 400 barbers, only 72 (18% had good knowledge about biological hazards associated to their profession, While only 61 (15.3% were practicing safely during barbering. Knowledge of the barbers was associated significantly with educational level, owner of the business, working hour and work experience, while practice was associated only with availability of UV sterilizers in the room and working hour. Conclusion Barbers’ practice and knowledge to prevent biological hazards associated with their profession is very poor. Thus, giving training for the Barbers is


    Stefan NEDELEA


    In the context of contemporary economy logistics changes refer to the emergence of new inter-organizational logistics structures such as logistics networks, and to a number of alterations in organizations’ vision and conduct regarding the role and importance of knowledge. The research focuses on identifying the instruments promoting inter-organizational knowledge transfer within logistics networks provided that each organization relies on its own knowledge and organizational skills to ensure ...

  2. Knowledge-Based Network Operations

    Wu, Chuan-lin; Hung, Chaw-Kwei; Stedry, Steven P.; McClure, James P.; Yeh, Show-Way


    An expert system is being implemented for enhancing operability of the Ground Communication Facility (GCF) of Jet Propulsion Laboratory's (JPL) Deep Space Network (DSN). The DSN is a tracking network for all of JPL's spacecraft plus a subset of spacecrafts launched by other NASA centers. A GCF upgrade task is set to replace the current GCF aging system with new, modern equipments which are capable of using knowledge-based monitor and control approach. The expert system, implemented in terms of KEE and SUN workstation, is used for performing network fault management, configuration management, and performance management in real-time. Monitor data are collected from each processor and DSCC's in every five seconds. In addition to serving as input parameters of the expert system, extracted management information is used to update a management information database. For the monitor and control purpose, software of each processor is divided into layers following the OSI standard. Each layer is modeled as a finite state machine. A System Management Application Process (SMAP) is implemented at application layer, which coordinates layer managers of the same processor and communicates with peer SMAPs of other processors. The expert system will be tuned by augmenting the production rules as the operation is going on, and its performance will be measured.

  3. A knowledge-based clustering algorithm driven by Gene Ontology.

    Cheng, Jill; Cline, Melissa; Martin, John; Finkelstein, David; Awad, Tarif; Kulp, David; Siani-Rose, Michael A


    We have developed an algorithm for inferring the degree of similarity between genes by using the graph-based structure of Gene Ontology (GO). We applied this knowledge-based similarity metric to a clique-finding algorithm for detecting sets of related genes with biological classifications. We also combined it with an expression-based distance metric to produce a co-cluster analysis, which accentuates genes with both similar expression profiles and similar biological characteristics and identifies gene clusters that are more stable and biologically meaningful. These algorithms are demonstrated in the analysis of MPRO cell differentiation time series experiments. PMID:15468759

  4. Biological Nature of Knowledge in the Learning Organisation

    Hall, William P.


    Purpose: To develop a biological approach to the analysis of learning organisations based on complexity theory, autopoiesis, and evolutionary epistemology. Design/methodology/approach: This paper synthesises ideas from disciplines ranging from physics, epistemology and philosophy of science to military affairs, to sketch a scientific framework in…

  5. The New Economy- Knowledge Based Economy

    Carmen MARIN


    Full Text Available The aim of this paper is to emphasize the importance of knowledgebased economy, in this time characterized by fast changes and sometimes radical changes, it is impossible to resist without adapting, both people and the organizations too. The matter of the paper develops knowledge based economy concept: elements, definitions of the knowledge based economy, stages and themain knowledge codification. In the end of the paper, the author presents the importance of economy knowledge, in Romanian organizations.

  6. Biology Faculty at Large Research Institutions: The Nature of their Pedagogical Content Knowledge

    Hill, Kathleen M.

    To address the need of scientists and engineers in the United States workforce and ensure that students in higher education become scientifically literate, research and policy has called for improvements in undergraduate education in the sciences. One particular pathway for improving undergraduate education in the science fields is to reform undergraduate teaching. Only a limited number of studies have explored the pedagogical content knowledge of postsecondary level teachers. This study was conducted to characterize the PCK of biology faculty and explore the factors influencing their PCK. Data included semi-structured interviews, classroom observations, documents, and instructional artifacts. A qualitative inquiry was designed to conduct an in-depth investigation focusing on the PCK of six biology instructors, particularly the types of knowledge they used for teaching biology, their perceptions of teaching, and the social interactions and experiences that influenced their PCK. The findings of this study reveal that the PCK of the biology faculty included eight domains of knowledge: (1) content, (2) context, (3) learners and learning, (4) curriculum, (5) instructional strategies, (6) representations of biology, (7) assessment, and (8) building rapport with students. Three categories of faculty PCK emerged: (1) PCK as an expert explainer, (2) PCK as an instructional architect, and (3) a transitional PCK, which fell between the two prior categories. Based on the interpretations of the data, four social interactions and experiences were found to influence biology faculty PCK: (1) teaching experience, (2) models and mentors, (3) collaborations about teaching, and (4) science education research. The varying teaching perspectives of the faculty also influenced their PCK. This study shows that the PCK of biology faculty for teaching large introductory courses at large research institutions is heavily influenced by factors beyond simply years of teaching experience and

  7. Terminology-Based Approach: Knowledge Acquisition and Integration in Healthcare



    Full Text Available Healthcare organizations are increasingly choosing the Knowledge Management Systems for clinical use, which have been established in technical support organizations for several years. Technical support organization can make use of its Knowledge Management System to meets its customer needs using its infrastructure and established processes. Success of Knowledge Management System in a healthcare organization mainly depends on the practice of healthcare professionals. Knowledge acquisition is very vital in healthcare than the application in technical support. The aim is to provide efficient access to heterogeneous biological textual data and databases, enabling users to integrate a wide range of textual and non-textual resources effortlessly. The main objective of the system is to make easier knowledge acquisition through query answering against XML-based documents in Healthcare specifically in the domain of molecular biology.

  8. Investigating the Effectiveness of an Inquiry-Based Intervention on Human Reproduction in Relation to Students' Gender, Prior Knowledge and Motivation for Learning in Biology

    Hadjichambis, Andreas Ch.; Georgiou, Yiannis; Paraskeva-Hadjichambi, Demetra; Kyza, Eleni A.; Mappouras, Demetrios


    Despite the importance of understanding how the human reproductive system works, adolescents worldwide exhibit weak conceptual understanding, which leads to serious risks, such as unwanted pregnancies and sexually transmitted diseases. Studies focusing on the development and evaluation of inquiry-based learning interventions, promoting the…

  9. Enhancing Interpretability of Gene Signatures with Prior Biological Knowledge.

    Squillario, Margherita; Barbieri, Matteo; Verri, Alessandro; Barla, Annalisa


    Biological interpretability is a key requirement for the output of microarray data analysis pipelines. The most used pipeline first identifies a gene signature from the acquired measurements and then uses gene enrichment analysis as a tool for functionally characterizing the obtained results. Recently Knowledge Driven Variable Selection (KDVS), an alternative approach which performs both steps at the same time, has been proposed. In this paper, we assess the effectiveness of KDVS against standard approaches on a Parkinson's Disease (PD) dataset. The presented quantitative analysis is made possible by the construction of a reference list of genes and gene groups associated to PD. Our work shows that KDVS is much more effective than the standard approach in enhancing the interpretability of the obtained results. PMID:27600081

  10. Biological evolution and Brazilian students: knowledge and acceptance

    Graciela da Silva Oliveira


    Full Text Available The aim of this study was to verify topics of the biological evolution theory Brazilian students affirm to know and their relation with variables such as sex, age, geographical localization, socioeconomical aspects, religion and science. 2.404 high school students (55.1% girls enrolled in 78 Brazilian schools took part of the research. The data was generated through a questionnaire and analyzed using the software Statistical Package for Social Science (SPSS version 18.0. The results point out that the knowledge of topics about evolution is low among students and influenced by the variables tested, the associations identified happened in a diversified way, and in lower or higher intensity according to the context studied.

  11. Neighborhood Mixture Model for Knowledge Base Completion

    Nguyen, Dat Quoc; Sirts, Kairit; Qu, Lizhen; Johnson, Mark


    Knowledge bases are useful resources for many natural language processing tasks, however, they are far from complete. In this paper, we define a novel entity representation as a mixture of its neighborhood in the knowledge base and apply this technique on TransE-a well-known embedding model for knowledge base completion. Experimental results show that the neighborhood information significantly helps to improve the results of the TransE, leading to better performance than obtained by other sta...

  12. Knowledge-based system for manufacturing sustainability

    Giovannini, Antonio; Aubry, Alexis; Panetto, Hervé; Dassisti, Michele; El Haouzi, Hind


    Today, sustainability becomes one of the biggest challenges. It represents a key issue in every production activity. To face this issue, a possible solution is to enhance knowledge usage in manufacturing and sustainability domains. In this paper, we extend the ONTO-PDM ontology for formalizing sustainable manufacturing knowledge. An industrial case is presented for instantiating the extension. Moreover we design a knowledge-based system, which exploits sustainable manufacturing knowledge for ...

  13. Knowledge-acquisition tools for medical knowledge-based systems.

    Lanzola, G; Quaglini, S; Stefanelli, M


    Knowledge-based systems (KBS) have been proposed to solve a large variety of medical problems. A strategic issue for KBS development and maintenance are the efforts required for both knowledge engineers and domain experts. The proposed solution is building efficient knowledge acquisition (KA) tools. This paper presents a set of KA tools we are developing within a European Project called GAMES II. They have been designed after the formulation of an epistemological model of medical reasoning. The main goal is that of developing a computational framework which allows knowledge engineers and domain experts to interact cooperatively in developing a medical KBS. To this aim, a set of reusable software components is highly recommended. Their design was facilitated by the development of a methodology for KBS construction. It views this process as comprising two activities: the tailoring of the epistemological model to the specific medical task to be executed and the subsequent translation of this model into a computational architecture so that the connections between computational structures and their knowledge level counterparts are maintained. The KA tools we developed are illustrated taking examples from the behavior of a KBS we are building for the management of children with acute myeloid leukemia. PMID:9082135

  14. Automatic Knowledge Base Evolution by Learning Instances

    Kim, Sundong


    Knowledge base is the way to store structured and unstructured data throughout the web. Since the size of the web is increasing rapidly, there are huge needs to structure the knowledge in a fully automated way. However fully-automated knowledge-base evolution on the Semantic Web is a major challenges, although there are many ontology evolution techniques available. Therefore learning ontology automatically can contribute to the semantic web society significantly. In this paper, we propose ful...

  15. Knowledge bases in medicine: a review.

    Perry, C. A.


    Efforts to represent knowledge effectively have been central to progress in various aspects of medical informatics. These efforts range from relatively simple "electronic textbooks" to fairly sophisticated knowledge-based systems, which function as well as, or even better than, human experts faced with similar problems. Knowledge bases have been developed in many fields, but the relatively limited domains and structured language of medicine, as well as the importance of information in the pro...


    Alexandru-Emil POPA


    In order to establish the premises of knowledge based economy (KBE) in Romania we have to measure the inputs of knowledge. This study is presenting the stage of transition at knowledge-based economy of Romania by measuring four important indicators: research and development expenditures as percentage of GDP, human resources in science and technology as a share of labor force, the number of patents filled at the European Patent Office or under the European Patent Convention and the volume of h...

  17. Case Base Mining for Adaptation Knowledge Acquisition

    D'Aquin, Mathieu; Badra, Fadi; Lafrogne, Sandrine; Lieber, Jean; Napoli, Amedeo; Szathmary, Laszlo


    International audience In case-based reasoning, the adaptation of a source case in order to solve the target problem is at the same time crucial and difficult to implement. The reason for this difficulty is that, in general, adaptation strongly depends on domain-dependent knowledge. This fact motivates research on adaptation knowledge acquisition (AKA). This paper presents an approach to AKA based on the principles and techniques of knowledge discovery from databases and data-mining. It is...

  18. Knowledge Based Company– a Theoretical Approach

    Cuºu Dorinela


    In a stable economic environment, the change may be slow, and the organization would have time to react and maintain its competitive advantages. In contrast in a knowledge-based economy, the economic environment changes rapidly and the response is not the best alternative; in order to succeed, the organizations must be proactive, to anticipate, to be directed towards learning and permanently development. The main resource of a knowledge-based company is the knowledge. This company is focused ...


    Landström, Hans; Harirchi , Gouya; Åström, Fredrik


    Entrepreneurship research has a long tradition and since the 1980s the field has grown significantly. In this study we identify the ‘knowledge producers’ who have shaped the field over time and their core entrepreneurship research works. A unique database consisting of all references in twelve entrepreneurship ‘handbooks’ (or state-of-the-art books) has been developed. The chapters in these handbooks were written by experts within the field, and it can be assumed that the most frequently cite...

  20. Knowledge Transfer in Biology and Translation across External Representations: Experts' Views and Challenges for Learning

    Schonborn, Konrad J.; Bogeholz, Susanne


    Recent curriculum reform promotes core competencies such as desired "content knowledge" and "communication" for meaningful learning in biology. Understanding in biology is demonstrated when pupils can apply acquired knowledge to new tasks. This process requires the transfer of knowledge and the subordinate process of translation across external…

  1. A Logical Framework for Knowledge Base Maintenance



    The maintenance sequences of a knowledge base and their limits are introduced.Some concepts used in knowledge base maintenance,such as new laws,user's rejections,and reconstructions of a knowledge base are defined;the related theorems are proved.A procedure is defined using transition systems;it generates maintenance sequences for a given user's model and a knowledge base.It is proved that all sequences produced by the procedure are convergent,and their limit is the set of true sentences of the model.Some computational aspects of reconstructions are studied.An R-calculus is given to deduce a reconstruction when a knowledge base meets a user's rejection.The work is compared with AGM's theory of belief revision.

  2. Examining beginning biology teachers' knowledge, beliefs, and practice for teaching natural selection

    Sickel, Aaron J.

    The teacher is the most important school-based factor in student learning. Thus, in order to improve student learning, we must examine how teachers learn to teach. My overarching research agenda centers upon K-16 science teacher learning and development. Within this agenda, I conduct studies focused on two strands of research: 1) How teachers learn to teach science using constructivist and inquiry-oriented teaching strategies; and 2) How teachers learn to teach biological evolution. This dissertation merges the two strands together, and consists of four related manuscripts that address how beginning biology teachers learn to teach natural selection using constructivist and inquiry-oriented teaching strategies. In the first manuscript, I reviewed the evolution education literature focused on K-12 teachers’ knowledge, beliefs, and practice for teaching evolution. Based upon findings across the studies, I articulated five goals for preparing teachers to teach evolution. The second and third manuscripts are longitudinal empirical studies focused on three beginning biology teachers learning to teach natural selection using the 5E instructional model and interactive classroom simulations. The fourth manuscript is a practitioner article that explains how to teach natural selection simulations using a constructivist, analogy-based teaching strategy. Findings that cut across the four manuscripts are organized into the following themes: (A) The participants developed some common types of knowledge for teaching natural selection, yet also developed in unique ways. All participants developed knowledge of the horizontal curriculum. Yet, participants also developed different types of knowledge. For example, participants who had taken an evolution course developed more integrated pedagogical content knowledge for teaching the core concepts of natural selection. The participant who integrated discipline-level knowledge for teaching science through inquiry with topic

  3. Regional Convergence in Knowledge-based Economy

    Maryam Fattahi


    Full Text Available Nowadays, the world economies are rapidly moving towards being more Knowledge-based Economy (KBE and supporting the force of knowledge as a vital component of economic growth. This recent acceleration in the transition to Knowledge-based Economy in the world, has affected regional economic performance. In this paper, we surveyed the regional convergence in Knowledge-based Economy for selected Asia and pacific countries. We used a growth model in Barro and Sala-i-Martin framework (1995 for the period of 1995-2009. It includes a panel data set consisting of the annual growth rate of GDP per capita for selected Asia and pacific countries and a group of indicators that define the situation of Knowledge-based Economy in countries. The empirical results indicate that the absolute and the conditional convergence are not rejected for selected countries. The investigation on robustness of the model results confirms the existence of regional convergence for studied countries.


    Ladislav Burita; Pavel Gardavsky


    The article presents the knowledge systems developed by using the software AToM and the experience with their application for teaching and universities cooperation. The theoretical bases of the solution are Topic Maps; the software AToM is described and individual cases of the knowledge systems are introduced. The article reflects the years of experience in the cooperation of the knowledge systems development with the AION CS Company. Two examples are presented in detail: “Conferences” – know...

  5. Interactive Knowledge Acquisition in Case Based Reasoning

    Cordier, Amélie; Fuchs, Béatrice; Lieber, Jean; Mille, Alain


    International audience In Case Based Reasoning (CBR), knowledge acquisition plays an important role as it allows to progressively improve the system's competencies. One of the approaches of knowledge acquisition consists in performing it while the system is used to solve a problem. An advantage of this strategy is that it is not to constraining for the expert: the system exploits its interactions to acquire pieces of knowledge it needs to solve the current problem and takes the opportunity...

  6. Quantitative utilization of prior biological knowledge in the Bayesian network modeling of gene expression data

    Gao Shouguo


    Full Text Available Abstract Background Bayesian Network (BN is a powerful approach to reconstructing genetic regulatory networks from gene expression data. However, expression data by itself suffers from high noise and lack of power. Incorporating prior biological knowledge can improve the performance. As each type of prior knowledge on its own may be incomplete or limited by quality issues, integrating multiple sources of prior knowledge to utilize their consensus is desirable. Results We introduce a new method to incorporate the quantitative information from multiple sources of prior knowledge. It first uses the Naïve Bayesian classifier to assess the likelihood of functional linkage between gene pairs based on prior knowledge. In this study we included cocitation in PubMed and schematic similarity in Gene Ontology annotation. A candidate network edge reservoir is then created in which the copy number of each edge is proportional to the estimated likelihood of linkage between the two corresponding genes. In network simulation the Markov Chain Monte Carlo sampling algorithm is adopted, and samples from this reservoir at each iteration to generate new candidate networks. We evaluated the new algorithm using both simulated and real gene expression data including that from a yeast cell cycle and a mouse pancreas development/growth study. Incorporating prior knowledge led to a ~2 fold increase in the number of known transcription regulations recovered, without significant change in false positive rate. In contrast, without the prior knowledge BN modeling is not always better than a random selection, demonstrating the necessity in network modeling to supplement the gene expression data with additional information. Conclusion our new development provides a statistical means to utilize the quantitative information in prior biological knowledge in the BN modeling of gene expression data, which significantly improves the performance.

  7. Knowledge Based Systems and Metacognition in Radar

    Capraro, Gerard T.; Wicks, Michael C.

    An airborne ground looking radar sensor's performance may be enhanced by selecting algorithms adaptively as the environment changes. A short description of an airborne intelligent radar system (AIRS) is presented with a description of the knowledge based filter and detection portions. A second level of artificial intelligence (AI) processing is presented that monitors, tests, and learns how to improve and control the first level. This approach is based upon metacognition, a way forward for developing knowledge based systems.

  8. The Knowledge Bases of the Expert Teacher.

    Turner-Bisset, Rosie


    Presents a model for knowledge bases for teaching that will act as a mental map for understanding the complexity of teachers' professional knowledge. Describes the sources and evolution of the model, explains how the model functions in practice, and provides an illustration using an example of teaching in history. (CMK)

  9. Topic Maps Based Project Knowledge Management

    Wu Xiaofan; Zhou Liang; Zhang Lei; Li Lingzhi; Ding Qiulin


    Based on topic maps, a preprocessing scheme using similarity comparision is presented and applied in knowledge management.Topic and occurrence-oriented merging algorithm is also introduced to implement knowledge integration for the sub-system. An Omnigator-supported example from an aeroaustic institute is utilised to validate the preprocessing method and the result indicates it can speed up the research schedule.

  10. Efficient Knowledge Base Management in DCSP

    Jiang, Hong


    DCSP (Distributed Constraint Satisfaction Problem) has been a very important research area in AI (Artificial Intelligence). There are many application problems in distributed AI that can be formalized as DSCPs. With the increasing complexity and problem size of the application problems in AI, the required storage place in searching and the average searching time are increasing too. Thus, to use a limited storage place efficiently in solving DCSP becomes a very important problem, and it can help to reduce searching time as well. This paper provides an efficient knowledge base management approach based on general usage of hyper-resolution-rule in consistence algorithm. The approach minimizes the increasing of the knowledge base by eliminate sufficient constraint and false nogood. These eliminations do not change the completeness of the original knowledge base increased. The proofs are given as well. The example shows that this approach decrease both the new nogoods generated and the knowledge base greatly. Thus...


    Ladislav Burita


    Full Text Available The article presents the knowledge systems developed by using the software AToM and the experience with their application for teaching and universities cooperation. The theoretical bases of the solution are Topic Maps; the software AToM is described and individual cases of the knowledge systems are introduced. The article reflects the years of experience in the cooperation of the knowledge systems development with the AION CS Company. Two examples are presented in detail: “Conferences” – knowledge system used for education and “MilUNI” –system for military universities cooperation.

  12. Knowledge Management Based on Big Data Processing

    Li Baoan


    Full Text Available At present, many large enterprises, like oil industry accumulated a large amount of data with a range of potential value of knowledge in their value activities over the years. How to help them to put these data into wealth are common problems faced by IT industry and academia. This study analyzed the five key problems of big data processing and knowledge management in-depth and then explained the composition and technical characteristics of knowledge management system based on big data processing. It explored the new approach of knowledge management which can adapt to the ever-change demands of enterprises.

  13. Knowledge discovery for stochastic models of biological systems

    Forlin, Michele


    Biology is the science of life and living organisms. Empowered by the deployment of several automated experimental frameworks, this discipline has seen a tremendous growth during the last decades. Recently, the focus towards studying biological systems holistically, has lead to biology converging with other disciplines. In particular, computer science is playing an increasingly important role in biology, because of its ability to disentangle complex system level issues. This increasing inter...

  14. Measuring Inconsistency in Probabilistic Knowledge Bases

    Thimm, Matthias


    This paper develops an inconsistency measure on conditional probabilistic knowledge bases. The measure is based on fundamental principles for inconsistency measures and thus provides a solid theoretical framework for the treatment of inconsistencies in probabilistic expert systems. We illustrate its usefulness and immediate application on several examples and present some formal results. Building on this measure we use the Shapley value-a well-known solution for coalition games-to define a sophisticated indicator that is not only able to measure inconsistencies but to reveal the causes of inconsistencies in the knowledge base. Altogether these tools guide the knowledge engineer in his aim to restore consistency and therefore enable him to build a consistent and usable knowledge base that can be employed in probabilistic expert systems.

  15. Case Base Mining for Adaptation Knowledge Acquisition

    D'Aquin, Mathieu; Lafrogne, Sandrine; Lieber, Jean; Napoli, Amedeo; Szathmary, Laszlo


    In case-based reasoning, the adaptation of a source case in order to solve the target problem is at the same time crucial and difficult to implement. The reason for this difficulty is that, in general, adaptation strongly depends on domain-dependent knowledge. This fact motivates research on adaptation knowledge acquisition (AKA). This paper presents an approach to AKA based on the principles and techniques of knowledge discovery from databases and data-mining. It is implemented in CABAMAKA, a system that explores the variations within the case base to elicit adaptation knowledge. This system has been successfully tested in an application of case-based reasoning to decision support in the domain of breast cancer treatment.

  16. DNA Coding Based Knowledge Discovery Algorithm

    LI Ji-yun; GENG Zhao-feng; SHAO Shi-huang


    A novel DNA coding based knowledge discovery algorithm was proposed, an example which verified its validity was given. It is proved that this algorithm can discover new simplified rules from the original rule set efficiently.

  17. The Coming of Knowledge-Based Business.

    Davis, Stan; Botkin, Jim


    Economic growth will come from knowledge-based businesses whose "smart" products filter and interpret information. Businesses will come to think of themselves as educators and their customers as learners. (SK)


    Viorel Cornescu; Vladimir-Codrin Ionescu


    It is now widely recognized that the cultural model of an organization affects its economic performance and social determinant. In this context, the paper presents a representative number of conceptual approaches on organizational culture and defines the possible actions to reshape its management within the firm based on knowledge. Also, the paper outlined the priorities of modern management firms, based on knowledge within the organizational culture, which may cause design and operationaliza...

  19. Agent-oriented commonsense knowledge base

    陆汝钤; 石纯一; 张松懋; 毛希平; 徐晋晖; 杨萍; 范路


    Common sense processing has been the key difficulty in Al community. Through analyzing various research methods on common sense, a large-scale agent-oriented commonsense knowledge base is described in this paper. We propose a new type of agent——CBS agent, specify common sense oriented semantic network descriptive language-Csnet, augment Prolog for common sense, analyze the ontology structure, and give the execution mechanism of the knowledge base.

  20. An Insulating Glass Knowledge Base

    Michael L. Doll; Gerald Hendrickson; Gerard Lagos; Russell Pylkki; Chris Christensen; Charlie Cureija


    This report will discuss issues relevant to Insulating Glass (IG) durability performance by presenting the observations and developed conclusions in a logical sequential format. This concluding effort discusses Phase II activities and focuses on beginning to quantifying IG durability issues while continuing the approach presented in the Phase I activities (Appendix 1) which discuss a qualitative assessment of durability issues. Phase II developed a focus around two specific IG design classes previously presented in Phase I of this project. The typical box spacer and thermoplastic spacer design including their Failure Modes and Effect Analysis (FMEA) and Fault Tree diagrams were chosen to address two currently used IG design options with varying components and failure modes. The system failures occur due to failures of components or their interfaces. Efforts to begin quantifying the durability issues focused on the development and delivery of an included computer based IG durability simulation program. The focus/effort to deliver the foundation for a comprehensive IG durability simulation tool is necessary to address advancements needed to meet current and future building envelope energy performance goals. This need is based upon the current lack of IG field failure data and the lengthy field observation time necessary for this data collection. Ultimately, the simulation program is intended to be used by designers throughout the current and future industry supply chain. Its use is intended to advance IG durability as expectations grow around energy conservation and with the growth of embedded technologies as required to meet energy needs. In addition the tool has the immediate benefit of providing insight for research and improvement prioritization. Included in the simulation model presentation are elements and/or methods to address IG materials, design, process, quality, induced stress (environmental and other factors), validation, etc. In addition, acquired data

  1. Content-Related Knowledge of Biology Teachers from Secondary Schools: Structure and learning opportunities

    Großschedl, Jörg; Mahler, Daniela; Kleickmann, Thilo; Harms, Ute


    Teachers' content-related knowledge is a key factor influencing the learning progress of students. Different models of content-related knowledge have been proposed by educational researchers; most of them take into account three categories: content knowledge, pedagogical content knowledge, and curricular knowledge. As there is no consensus about the empirical separability (i.e. empirical structure) of content-related knowledge yet, a total of 134 biology teachers from secondary schools completed three tests which were to capture each of the three categories of content-related knowledge. The empirical structure of content-related knowledge was analyzed by Rasch analysis, which suggests content-related knowledge to be composed of (1) content knowledge, (2) pedagogical content knowledge, and (3) curricular knowledge. Pedagogical content knowledge and curricular knowledge are highly related (rlatent = .70). The latent correlations between content knowledge and pedagogical content knowledge (rlatent = .48)-and curricular knowledge, respectively (rlatent = .35)-are moderate to low (all ps pedagogical content knowledge, and curricular knowledge acquisition. Our results show that an in-depth training in teacher education, professional development, and teacher self-study are positively related to particular categories of content-related knowledge. Furthermore, our results indicate that teaching experience is negatively related to curricular knowledge, compared to no significant relationship with content knowledge and pedagogical content knowledge.


    Rus Mircea-Iosif


    Full Text Available The knowledge-based society is the stage where mankind is found and aims to raise the living standards of population but also to increase the level of knowledge. To achieve this latter goal, the states of the world, and especially those in the European Union, must ensure an adequate funding for its realization, and therefore in 2011 it was decided at EU level the achievement of an Innovation Union, in which are to be involved all the European countries, while to stimulate and finance research and innovation the Horizon 2020 program was proposed. The results of the Program, an ”Innovation Union” have begun to be felt, so in 2011, the major companies headquartered in the European Union increased their investments in R&D by 8.9% compared to 6.1% in 2010. This increase was almost equal to that of the U.S.A. companies (9%, higher than the world average (7.6% and superior to Japanese companies (1.5%. The sectors that used the research-development activity have tended to have increases in employment above average. I believe this information highlights the fact that the European Union may become attractive for research-development and innovation investments even for businesses outside the UE, and this can result in jobs creation and increasing competitivenees of this field of the states of the European Union. In the introductory part of the article, I have briefly presented general notions of the three component activities of the ”knowledge triangle”, in the second part I presented the knowledge society with several features, in the third part, I showed some provisions of the program to stimulate research and innovation Horizon 2020, in the fourth part, I presented an innovation activity connection to private enterprise and entrepreneurial initiative stimulation in the field innovation, and the conclusions shows that research does not stop with achieving the objectives and finding the outcomes research, but is it the background for further


    ZHANG Shijie; SONG Laigang


    In order to enhance the intelligent level of system and improve the interactivity with other systems, a knowledge and XML based computer aided process planning (CAPP) system is implemented. It includes user management, bill of materials(BOM) management, knowledge based process planning, knowledge management and database maintaining sub-systems. This kind of nesting knowledge representation method the system provided can represent complicated arithmetic and logical relationship to deal with process planning tasks. With the representation and manipulation of XML based technological file, the system solves some important problems in web environment such as information interactive efficiency and refreshing of web page. The CAPP system is written in ASP VBScript, JavaScript, Visual C++ languages and Oracle database. At present, the CAPP system is running in Shenyang Machine Tools. The functions of it meet the requirements of enterprise production.

  4. Intergenerational knowledge transfer in the academic environment of knowledge-based economy

    Viorel Lefter; Constantin Brătianu; Adriana Agapie; Simona Agoston; Ivona Orzea


    In the immediate future, intergenerational knowledge transfer is one of the knowledge-based economy’s main challenges since an inner motivational force powers knowledge transfer. Knowledge transfer from individuals to groups and organization must follow knowledge creation in order to transform individual into organizational knowledge, along the epistemological dimension of the Nonaka’s knowledge dynamics model. Moreover, the knowledge intensive organizations increase their fluxes of knowledge...

  5. Oceanographic ontology-based spatial knowledge query


    The construction of oceanographic ontologies is fundamental to the "digital ocean". Therefore, on the basis of introduction of new concept of oceanographic ontology, an oceanographic ontology-based spatial knowledge query (OOBSKQ) method was proposed and developed. Because the method uses a natural language to describe query conditions and the query result is highly integrated knowledge,it can provide users with direct answers while hiding the complicated computation and reasoning processes, and achieves intelligent,automatic oceanographic spatial information query on the level of knowledge and semantics. A case study of resource and environmental application in bay has shown the implementation process of the method and its feasibility and usefulness.


    Krzysztof Kubiak


    High-tech industry has been stimulating economic development, providing the market with innovative information and communication technologies. Some of these include mobile technologies, mainly associated with the use of Smartphones and tablets. Mobile devices run various types of software called applications. The purpose of this article is to evaluate a selection of Polish mobile applications in the context of their features typical for knowledge-based products. Such products carry knowledge ...

  7. The Ontology of Knowledge Based Optimization

    Nasution, Mahyuddin K. M.


    Optimization has been becoming a central of studies in mathematic and has many areas with different applications. However, many themes of optimization came from different area have not ties closing to origin concepts. This paper is to address some variants of optimization problems using ontology in order to building basic of knowledge about optimization, and then using it to enhance strategy to achieve knowledge based optimization.

  8. Education Management in Knowledge Based Society

    Daniela Todose


    Europe is developing its “knowledge society”. It passes from an economy based on traditional factors of production (land, labor, capital) to one in which the major components are information and knowledge. It is well known that the socio-economical and technological development has an important impact on the labor market in developed nations. So, more skills are needed and a flexible and dynamic labor supply. Nowadays, developed and developing nations are increasingly able to deliver high ski...


    Ramona – Diana Leon; Adrian Lupu; Anca – Codruta Manolache


    Increasingly more literature mention that in the current competitive environment, knowledge have become the main source of the competitive advantages, while recent researches regarding economic growth and development have defined knowledge as being the most critical resource of the emerging countries. Therefore, the organizations interest for knowledge has increased, the latter being defined as knowledge management process in order to meet existing needs, to identify and exploit existing and/...

  10. Knowledge based diagnostics in nuclear power plants

    In the paper to be given a special process diagnostic system (PDS) will be presented, taking into account corresponding user experiences. It must be seen the result of a long term work on computerized process surveillance and control on NPP; it includes a model based system for noise analysis of mechanical vibrations, which has been enhanced by using of knowledge based technique (expert systems). The paper will discuss the process diagnostic frame concept and emphasize the vibration analysis expertsystem RADEX, with the parts modelling (building a knowledge base), man-machine communication aspects, implementation. (author). 5 refs, 5 figs

  11. Knowledge-based support for a physician's workstation.

    Stanton, W. M.; Tang, P. C.


    We describe knowledge-based support for a Physician's Workstation prototype. Our knowledge base uses a qualitative simulation model of patient physiology. We present the motivation behind our design, discuss the components of the knowledge base, and show how the knowledge base supports a physician's workstation in the patient management process. We describe a graphical knowledge base editor used by the domain expert for knowledge acquisition, and a graphical knowledge base presenter which mon...

  12. Model-based explanation of plant knowledge

    Huuskonen, P.J. [VTT Electronics, Oulu (Finland). Embedded Software


    This thesis deals with computer explanation of knowledge related to design and operation of industrial plants. The needs for explanation are motivated through case studies and literature reviews. A general framework for analysing plant explanations is presented. Prototypes demonstrate key mechanisms for implementing parts of the framework. Power plants, steel mills, paper factories, and high energy physics control systems are studied to set requirements for explanation. The main problems are seen to be either lack or abundance of information. Design knowledge in particular is found missing at plants. Support systems and automation should be enhanced with ways to explain plant knowledge to the plant staff. A framework is formulated for analysing explanations of plant knowledge. It consists of three parts: 1. a typology of explanation, organised by the class of knowledge (factual, functional, or strategic) and by the target of explanation (processes, automation, or support systems), 2. an identification of explanation tasks generic for the plant domain, and 3. an identification of essential model types for explanation (structural, behavioural, functional, and teleological). The tasks use the models to create the explanations of the given classes. Key mechanisms are discussed to implement the generic explanation tasks. Knowledge representations based on objects and their relations form a vocabulary to model and present plant knowledge. A particular class of models, means-end models, are used to explain plant knowledge. Explanations are generated through searches in the models. Hypertext is adopted to communicate explanations over dialogue based on context. The results are demonstrated in prototypes. The VICE prototype explains the reasoning of an expert system for diagnosis of rotating machines at power plants. The Justifier prototype explains design knowledge obtained from an object-oriented plant design tool. Enhanced access mechanisms into on-line documentation are

  13. Knowledge base verification based on enhanced colored petri net

    Verification is a process aimed at demonstrating whether a system meets it's specified requirements. As expert systems are used in various applications, the knowledge base verification of systems takes an importatn position. The conventional Petri net approach that has been studied recently in order to verify the knowledge base is found that it is inadequate to verify the knowledge base of large and complex system, such as alarm processing system of nuclear power plant. Thus, we propose an improved method that models the knowledge base as enhanced colored Petri net. In this study, we analyze the reachability and the error characteristics of the knowledge base and apply the method to verification of simple knowledge base

  14. Knowledge base verification based on enhanced colored petri net

    Kim, Jong Hyun; Seong, Poong Hyun [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)


    Verification is a process aimed at demonstrating whether a system meets it`s specified requirements. As expert systems are used in various applications, the knowledge base verification of systems takes an important position. The conventional Petri net approach that has been studied recently in order to verify the knowledge base is found that it is inadequate to verify the knowledge base of large and complex system, such as alarm processing system of nuclear power plant. Thus, we propose an improved method that models the knowledge base as enhanced colored Petri net. In this study, we analyze the reachability and the error characteristics of the knowledge base and apply the method to verification of simple knowledge base. 8 refs., 4 figs. (Author)


    Ramona – Diana Leon


    Full Text Available Increasingly more literature mention that in the current competitive environment, knowledge have become the main source of the competitive advantages, while recent researches regarding economic growth and development have defined knowledge as being the most critical resource of the emerging countries.Therefore, the organizations interest for knowledge has increased, the latter being defined as knowledge management process in order to meet existing needs, to identify and exploit existing and/or acquired knowledge and developing new opportunities.In other words, knowledge management facilitates productive information usage, intelligence growth, storing intellectual capital, strategic planning, flexible acquisition, collection of best practices, increasing the likelihood of being successful as well as a more productive collaboration within the company.In order to benefit from all these advantages, it is required the usage of specific tools including models and systems to stimulate the creation, dissemination and use of knowledge held by each employee and the organization as a whole.

  16. An Optimization-Based Framework for the Transformation of Incomplete Biological Knowledge into a Probabilistic Structure and Its Application to the Utilization of Gene/Protein Signaling Pathways in Discrete Phenotype Classification.

    Esfahani, Mohammad Shahrokh; Dougherty, Edward R


    Phenotype classification via genomic data is hampered by small sample sizes that negatively impact classifier design. Utilization of prior biological knowledge in conjunction with training data can improve both classifier design and error estimation via the construction of the optimal Bayesian classifier. In the genomic setting, gene/protein signaling pathways provide a key source of biological knowledge. Although these pathways are neither complete, nor regulatory, with no timing associated with them, they are capable of constraining the set of possible models representing the underlying interaction between molecules. The aim of this paper is to provide a framework and the mathematical tools to transform signaling pathways to prior probabilities governing uncertainty classes of feature-label distributions used in classifier design. Structural motifs extracted from the signaling pathways are mapped to a set of constraints on a prior probability on a Multinomial distribution. Being the conjugate prior for the Multinomial distribution, we propose optimization paradigms to estimate the parameters of a Dirichlet distribution in the Bayesian setting. The performance of the proposed methods is tested on two widely studied pathways: mammalian cell cycle and a p53 pathway model. PMID:26671803

  17. Information modelling and knowledge bases XXV

    Tokuda, T; Jaakkola, H


    Because of our ever increasing use of and reliance on technology and information systems, information modelling and knowledge bases continue to be important topics in those academic communities concerned with data handling and computer science. As the information itself becomes more complex, so do the levels of abstraction and the databases themselves. This book is part of the series Information Modelling and Knowledge Bases, which concentrates on a variety of themes in the important domains of conceptual modeling, design and specification of information systems, multimedia information modelin

  18. A programmable approach to revising knowledge bases

    LUAN Shangmin; DAI Guozhong; LI Wei


    This paper presents a programmable approach to revising knowledge bases consisting of clauses. Some theorems and lemmas are shown in order to give procedures for generating maximally consistent subsets. Then a complete procedure and an incomplete procedure for generating the maximal consistent subsets are presented, and the correctness of the procedures is also shown. Furthermore, a way to implement knowledge base revision is presented, and a prototype system is introduced. Compared with related works, the main characteristic of our approach is that the approach can be implemented by a computer program.

  19. Building a Knowledge Base from Learning Objects

    Fredlund, Per Kristen


    The goal of this thesis has been to investigate if it is possible to develop a knowledge structure,knowledge base, based on learning objects. In this connection a learning object is a digital unitwhich should, as a minimum, contain a picture and some text. Most likely a learning objectwould function as a container with anchors for video, animations and links to html-pages.For every learning object there exists a textual description. If we consider the learning object asan overhead presented i...

  20. A multivalued knowledge-base model

    Achs, Agnes


    The basic aim of our study is to give a possible model for handling uncertain information. This model is worked out in the framework of DATALOG. At first the concept of fuzzy Datalog will be summarized, then its extensions for intuitionistic- and interval-valued fuzzy logic is given and the concept of bipolar fuzzy Datalog is introduced. Based on these ideas the concept of multivalued knowledge-base will be defined as a quadruple of any background knowledge; a deduction mechanism; a connecting algorithm, and a function set of the program, which help us to determine the uncertainty levels of the results. At last a possible evaluation strategy is given.

  1. A Kabbalah System Theory of Ontological and Knowledge Engineering for Knowledge Based Systems

    Gabriel Burstein; Constantin Virgil Negoita


    Using the Kabbalah system theory (KST) developed in [1], [2], we propose an ontological engineering for knowledge representation of domains in terms of concept systems in knowledge based systems in artificial intelligence. KST is also used for the knowledge engineering of the knowledge model building based on ontology. KST provides thus an integrative, unifying, domain independent framework for both the knowledge representation via ontologies and knowledge model building via knowledge enginee...

  2. DKBLM—Deep Knowledge Based Learning Methodology



    To solve the Imperfect Theory Problem(ITP)faced by Explanation Based Generalization(EBG),this paper proposes a methodology,Deep Knowledge Based Learning Methodology(DKBLM)by name and gives an implementation of DKBLM,called Hierarchically Distributed Learning System(HDLS).As an example of HDLS's application,this paper shows a learning system(MLS)in meteorology domain and its running with a simplified example.DKBLM can acquire experiential knowledge with causality in it.It is applicable to those kinds of domains,in which experiments are relatively difficults to caryy out,and in which there exist many available knowledge systems at different levels for the same domain(such as weather forecasting).

  3. Knowledge-based machine indexing from natural language text: Knowledge base design, development, and maintenance

    Genuardi, Michael T.


    One strategy for machine-aided indexing (MAI) is to provide a concept-level analysis of the textual elements of documents or document abstracts. In such systems, natural-language phrases are analyzed in order to identify and classify concepts related to a particular subject domain. The overall performance of these MAI systems is largely dependent on the quality and comprehensiveness of their knowledge bases. These knowledge bases function to (1) define the relations between a controlled indexing vocabulary and natural language expressions; (2) provide a simple mechanism for disambiguation and the determination of relevancy; and (3) allow the extension of concept-hierarchical structure to all elements of the knowledge file. After a brief description of the NASA Machine-Aided Indexing system, concerns related to the development and maintenance of MAI knowledge bases are discussed. Particular emphasis is given to statistically-based text analysis tools designed to aid the knowledge base developer. One such tool, the Knowledge Base Building (KBB) program, presents the domain expert with a well-filtered list of synonyms and conceptually-related phrases for each thesaurus concept. Another tool, the Knowledge Base Maintenance (KBM) program, functions to identify areas of the knowledge base affected by changes in the conceptual domain (for example, the addition of a new thesaurus term). An alternate use of the KBM as an aid in thesaurus construction is also discussed.

  4. The Biological Bases of Conformity

    ThomasJoshau HenryMorgan


    Full Text Available Humans are characterized by an extreme dependence on culturally transmitted information and recent formal theory predicts that natural selection should favour adaptive learning strategies that facilitate effective use of social information in decision making. One strategy that has attracted particular attention is conformist transmission, defined as the disproportionately likely adoption of the most common variant. Conformity has historically been emphasized as significant in the social psychology literature, and recently there have also been reports of conformist behaviour in nonhuman animals. However, mathematical analyses differ in how important and widespread they expect conformity to be, and relevant experimental work is scarce, and generates findings that are both mutually contradictory and inconsistent with the predictions of the models. We review the relevant literature considering the causation, function, history and ontogeny of conformity and describe a computer-based experiment on human subjects that we carried out in order to resolve ambiguities. We found that only when many demonstrators were available and subjects were uncertain was subject behaviour conformist. A further analysis found that the underlying response to social information alone was generally conformist. Thus, our data are consistent with a conformist use of social information, but as subject’s behaviour is the result of both social and asocial influences, the resultant behaviour may not be conformist. We end by relating these findings to an embryonic cognitive neuroscience literature that has recently begun to explore the neural bases of social learning. Here conformist transmission may be a particularly useful case study, not only because there are well-defined and tractable opportunities to characterize the biological underpinnings of this form of social learning, but also because early findings imply that humans may possess specific cognitive adaptations for

  5. Knowledge formations in Problem Based Learning

    Larsen, Verner


    The paper presents some of the results from a recent completed Ph.D. program about disciplinarity and inter-disciplinarity in problem based learning (PBL). Disciplinary content in PBL-programs has been questioned during recent years, so stronger concepts of how knowledge is actually organized and...... types constitute certain ‘modalities’ of transversality. Two educational contexts, Nursing and Constructing Architect education, have been used as a case study research in order to demonstrate how institutional practices show different modalities of transversal knowledge in their PBL-courses. For the...

  6. Conservation Biology and Traditional Ecological Knowledge: Integrating Academic Disciplines for Better Conservation Practice

    Adam P. Henne


    Full Text Available Conservation biology and environmental anthropology are disciplines that are both concerned with the identification and preservation of diversity, in one case biological and in the other cultural. Both conservation biology and the study of traditional ecoloigcal knowledge function at the nexus of the social and natural worlds, yet historically there have been major impediments to integrating the two. Here we identify linguistic, cultural, and epistemological barriers between the two disciplines. We argue that the two disciplines are uniquely positioned to inform each other and to provide critical insights and new perspectives on the way these sciences are practiced. We conclude by synthesizing common themes found in conservation success stories, and by making several suggestions on integration. These include cross-disciplinary publication, expanding memberships in professional societies and conducting multidisciplinary research based on similar interests in ecological process, taxonomy, or geography. Finally, we argue that extinction threats, be they biological or cultural/linguistic are imminent, and that by bringing these disciplines together we may be able to forge synergistic conservation programs capable of protecting the vivid splendor of life on Earth.

  7. Knowledge-based information systems in practice

    Jain, Lakhmi; Watada, Junzo; Howlett, Robert


    This book contains innovative research from leading researchers who presented their work at the 17th International Conference on Knowledge-Based and Intelligent Information and Engineering Systems, KES 2013, held in Kitakyusha, Japan, in September 2013. The conference provided a competitive field of 236 contributors, from which 38 authors expanded their contributions and only 21 published. A plethora of techniques and innovative applications are represented within this volume. The chapters are organized using four themes. These topics include: data mining, knowledge management, advanced information processes and system modelling applications. Each topic contains multiple contributions and many offer case studies or innovative examples. Anyone that wants to work with information repositories or process knowledge should consider reading one or more chapters focused on their technique of choice. They may also benefit from reading other chapters to assess if an alternative technique represents a more suitable app...

  8. Evolutionary biology as a link between religion and knowledge

    C. W. du Toit


    Full Text Available It would appear that the epistemological tradition of the West is culminating in the present science-religion debate. The evolutionary model is being used increasingly in different disciplines as a guideline to understand humans and their action in the world. The struggle for explaining the action of God has shifted from the world of history and texts to the invisible level of quantum physics and molecular biology. It seems that levels of indeterminacy in quantum mechanics and autopoietic systems offer space to explain the action of God. On the human level integrity is sought by linking the highest level of consciousness and rationality to the very basic level of molecular and genetic structures. These issues are dealt with and specific attention is given to autopoietic systems and the biological roots of rationality.

  9. Knowledge management – a source of sustainable competitiveness in the knowledge based economy

    Claudia OGREAN


    Confirming the well known thesis knowledge is power, A. Toffler argued that the knowledge based society represents the acme of the human society development and P. Drucker said that the developed countries passing through the knowledge based society represents the biggest change of the modern world. That made possible and helped the emerging of the managerial revolution (defined as knowledge applied to knowledge itself) at the firm’s level. Under these circumstances, knowledge has to be seen ...

  10. The functionality of biological knowledge in the workplace. Integrating school and workplace learning about reproduction

    Mazereeuw, M.


    This thesis reports on a design research project about a learning, supervising and teaching strategy to enable students in agricultural preparatory vocational secondary education (VMBO) to recognize the functionality of biological knowledge of reproduction in work placement sites. Although biological knowledge can be functionally used in many work placement sites it is not evident that students recognize that this is the case. Workplace characteristics, participation in work actions and workp...

  11. XML-Based SHINE Knowledge Base Interchange Language

    James, Mark; Mackey, Ryan; Tikidjian, Raffi


    The SHINE Knowledge Base Interchange Language software has been designed to more efficiently send new knowledge bases to spacecraft that have been embedded with the Spacecraft Health Inference Engine (SHINE) tool. The intention of the behavioral model is to capture most of the information generally associated with a spacecraft functional model, while specifically addressing the needs of execution within SHINE and Livingstone. As such, it has some constructs that are based on one or the other.

  12. Knowledge-Based Query Construction Using the CDSS Knowledge Base for Efficient Evidence Retrieval

    Muhammad Afzal


    Full Text Available Finding appropriate evidence to support clinical practices is always challenging, and the construction of a query to retrieve such evidence is a fundamental step. Typically, evidence is found using manual or semi-automatic methods, which are time-consuming and sometimes make it difficult to construct knowledge-based complex queries. To overcome the difficulty in constructing knowledge-based complex queries, we utilized the knowledge base (KB of the clinical decision support system (CDSS, which has the potential to provide sufficient contextual information. To automatically construct knowledge-based complex queries, we designed methods to parse rule structure in KB of CDSS in order to determine an executable path and extract the terms by parsing the control structures and logic connectives used in the logic. The automatically constructed knowledge-based complex queries were executed on the PubMed search service to evaluate the results on the reduction of retrieved citations with high relevance. The average number of citations was reduced from 56,249 citations to 330 citations with the knowledge-based query construction approach, and relevance increased from 1 term to 6 terms on average. The ability to automatically retrieve relevant evidence maximizes efficiency for clinicians in terms of time, based on feedback collected from clinicians. This approach is generally useful in evidence-based medicine, especially in ambient assisted living environments where automation is highly important.

  13. Knowledge-based computer security advisor

    The rapid expansion of computer security information and technology has included little support to help the security officer identify the safeguards needed to comply with a policy and to secure a computing system. This paper reports that Los Alamos is developing a knowledge-based computer security system to provide expert knowledge to the security officer. This system includes a model for expressing the complex requirements in computer security policy statements. The model is part of an expert system that allows a security officer to describe a computer system and then determine compliance with the policy. The model contains a generic representation that contains network relationships among the policy concepts to support inferencing based on information represented in the generic policy description

  14. Educational Policies in Knowledge Based Society

    Tomita CIULEI


    Full Text Available The actual number – Volume 5, Issue 2, December 2013 – hosts the theme of “Educational Policies in the Knowledge Based Society”. The current issue of the journal falls in science education and educational policies as part of the social sciences field, including both theoretical articles and empirical research results. In the context of the knowledge based society we refer to the two major dimensions of educational policy: macro size, regarding the impact of systemic changes induced transformation of the legal framework of the system of financing education and research, of national programs related to education, research, youth, etc. on the one hand, and to micro size on the politics of sectoral actors represented by Universities, NGOs and other institutions providing education.

  15. Knowledge base system visualization reasoning model based on ICON

    Chen, Deyun; Pei, Shujun; Quan, Zhiying


    Knowledge base system is one of the most future branches for artificial intelligence facing with practical application. But the reasoning process of system is invisible, not visual and users cannot intervene the reasoning process, therefore for users the system is only a black box. This condition causes many users to take a suspicious attitude to the conclusions analyzing and drawing from the system, that means even though the system has the explanation function, but it is still not far enough. If we adopt graph or image technique to display this reasoning procedure interactively and dynamically which can make this procedure be visual, users can intervene the reasoning procedure which can greatly reduce users" gain giving, and at the same time it can provide a given method for integrity check to knowledge of the knowledge base. Therefore, we can say that reasoning visualization of knowledge base system has a further meaning than general visualization. In this paper the visual problem of reasoning process for knowledge base system on the basis of the formalized analysis for ICON system, Icon operation, syntax and semanteme of the statement is presented, a reasoning model of knowledge base system that has a visual characteristics is established, the model is used to do an integrity check in practical expert system and knowledge base, better effect is got.


    Vladimir-Codrin IONESCU; Viorel CORNESCU


    For sustainable competitive advantages gain, modern organizations, knowledge-based, must promote a proactive and flexible management, permanently connected to change which occur in business environment. Contextually, the paper analyses impact factors of the environment which could determine a firm to initiate a programme strategic organizational change. Likewise, the paper identifies the main organizational variables involved in a changing process and emphasizes the essential role which manag...

  17. Human Capital in the Knowledge Based Management



    All over the world, the problem of human capital acknowledge, it’s ways and means of shaping in order to improve it’s creative potential, tends to occupy a suitable place in the ensemble of all the organization’s management science and practice concerns. This study aims that, according to the theoretical ang pragmatical aquisitions, to present conceptual boundries about the human capital involvement in the knowledge based management. It starts with presenting the relations ballance and philos...




    Full Text Available For sustainable competitive advantages gain, modern organizations, knowledge-based, must promote a proactive and flexible management, permanently connected to change which occur in business environment. Contextually, the paper analyses impact factors of the environment which could determine a firm to initiate a programme strategic organizational change. Likewise, the paper identifies the main organizational variables involved in a changing process and emphasizes the essential role which managers and entrepreneurs have in substantiation, elaboration and implementation of organizational change models.

  19. Representations of the Nature of Scientific Knowledge in Turkish Biology Textbooks

    Irez, Serhat


    Considering the impact of textbooks on learning, this study set out to assess representations of the nature of scientific knowledge in Turkish 9th grade biology textbooks. To this end, the ten most commonly used 9th grade biology textbooks were analyzed. A qualitative research approach was utilized and the textbooks were analyzed using…

  20. Biological knowledge in the National Curriculum of High School: an historical and philosophical analysis from the statutes of biology

    Antônio Fernandes Nascimento Júnior


    Full Text Available We analyzed the National Curriculum for Secondary Schools with respect to the ontological, epistemological, historical, social and conceptual biology. This study aims to bring information and thinking about the inclusion of history and philosophy of biology for secondary education and for teacher training. We performed an analysis of PCNEM, PCNEM+ and Curriculum Guidelines as a whole from established categories. The results indicate a predominance of the ontological view of mechanistic biology. Epistemologically, although acknowledged, the question of scientific method is rarely discussed. The historical approach and social scientific activity and scientific knowledge are recognized by the documents, but an instrumental view prevails. The conceptual aspects are comprehensive and take into account the theories of structural biology. A philosophical discussion on the biology is missing in the parameters, indicating the need for the inclusion of issues related to ideas of determinism, chance and teleology.

  1. Knowledge base technology: a developer view

    G. Ginkul


    Full Text Available In present paper we have endeavoured to tell about some reasonings, conclusions and pricticals results, to which we have come being busy with one of most interesting problems of modern science. This paper is a brief report of the group of scientists from the Laboratory of Artificial Intelligence Systems about their experience of work in the field of knowledge engineering. The researches in this area was started in our Laboratory more than 10 years ago, i.e. about in the moment, when there was just another rise in Artificial Intelligence, caused by mass emerging of expert systems. The tasks of knowledge engineering were being varied, and focal point of our researches was being varied too. Certainly, we have not solved all the problems, originating in this area. Our knowledge still has an approximate nature, but nevertheless, the outcomes obtained by us seem rather important and interesting. So, we want to tell about our experience in building of knowledge-based systems, and expert systems, in particular.

  2. Conservation Biology and Traditional Ecological Knowledge: Integrating Academic Disciplines for Better Conservation Practice

    Adam P. Henne; Drew, Joshua A.


    Conservation biology and environmental anthropology are disciplines that are both concerned with the identification and preservation of diversity, in one case biological and in the other cultural. Both conservation biology and the study of traditional ecoloigcal knowledge function at the nexus of the social and natural worlds, yet historically there have been major impediments to integrating the two. Here we identify linguistic, cultural, and epistemological barriers between the two disciplin...

  3. How Knowledge of Pathogen Population Biology Informs Management of Septoria Tritici Blotch.

    McDonald, Bruce A; Mundt, Christopher C


    Zymoseptoria tritici (previously Mycosphaerella graminicola) causes Septoria tritici blotch (STB) on wheat. The population biology of Z. tritici has been exceptionally well characterized as a result of intensive studies conducted over nearly 30 years. These studies provided important insights into the biology, epidemiology and evolutionary history of Z. tritici that will prove useful for management of STB. The well-documented, rapid adaptation of Z. tritici populations to fungicide applications and deployment of wheat cultivars carrying both major gene and quantitative resistance reflects the high evolutionary potential predicted by the large effective population size, high degree of gene flow and high levels of recombination found in field populations of Z. tritici globally. QST studies that assessed the global diversity for several important quantitative traits confirmed the adaptive potential of field populations and laid the groundwork for quantitative trait loci (QTL) mapping studies. QTL mapping elucidated the genetic architecture of each trait and led to identification of candidate genes affecting fungicide resistance, thermal adaptation, virulence, and host specialization. The insights that emerged through these analyses of Z. tritici population biology can now be used to generate actionable disease management strategies aimed at sustainably reducing losses due to STB. The high evolutionary potential found in field populations of Z. tritici requires deployment of a corresponding dynamically diverse set of control measures that integrate cultural, chemical, biological and resistance breeding strategies. In this review, we describe and prioritize STB control strategies based on current knowledge of Z. tritici population biology and propose a future research agenda oriented toward long-term STB management. PMID:27111799

  4. Modeling Guru: Knowledge Base for NASA Modelers

    Seablom, M. S.; Wojcik, G. S.; van Aartsen, B. H.


    Modeling Guru is an on-line knowledge-sharing resource for anyone involved with or interested in NASA's scientific models or High End Computing (HEC) systems. Developed and maintained by the NASA's Software Integration and Visualization Office (SIVO) and the NASA Center for Computational Sciences (NCCS), Modeling Guru's combined forums and knowledge base for research and collaboration is becoming a repository for the accumulated expertise of NASA's scientific modeling and HEC communities. All NASA modelers and associates are encouraged to participate and provide knowledge about the models and systems so that other users may benefit from their experience. Modeling Guru is divided into a hierarchy of communities, each with its own set forums and knowledge base documents. Current modeling communities include those for space science, land and atmospheric dynamics, atmospheric chemistry, and oceanography. In addition, there are communities focused on NCCS systems, HEC tools and libraries, and programming and scripting languages. Anyone may view most of the content on Modeling Guru (available at, but you must log in to post messages and subscribe to community postings. The site offers a full range of "Web 2.0" features, including discussion forums, "wiki" document generation, document uploading, RSS feeds, search tools, blogs, email notification, and "breadcrumb" links. A discussion (a.k.a. forum "thread") is used to post comments, solicit feedback, or ask questions. If marked as a question, SIVO will monitor the thread, and normally respond within a day. Discussions can include embedded images, tables, and formatting through the use of the Rich Text Editor. Also, the user can add "Tags" to their thread to facilitate later searches. The "knowledge base" is comprised of documents that are used to capture and share expertise with others. The default "wiki" document lets users edit within the browser so others can easily collaborate on the

  5. Case-Based Knowledge and Planning

    Itzhak Gilboa; David Schmeidler


    "Case-Based Decision Theory" is a theory of decision making under uncertainty, suggesting that people tend to choose acts that performed well in similar cases they recall. The theory has been developed from a decision-/game-/economic-theoretical point of view, as a potential alternative to expected utility theory. In this paper we attempt to re-consider CBDT as a theory of knowledge representation and of planning, to contrast it with the rule-based approach, and to study its implications rega...

  6. Knowledge and Attitude Towards Epilepsy Among Biology Teachers in Fars Province, Iran

    Ali Akbar ASADI-POOYA


    Full Text Available How to Cite this Article: Asadi-Pooya AA, Torabi-Nami M. Knowledge and Attitude Towards Epilepsy Among Biology Teachers in Fars Province, Iran. IranianJournal of Child Neurology 2012;6(1:13-18.ObjectiveThis study investigates the awareness and perception on “epilepsy” amongst biology teachers in Fars province, Iran.Materials & MethodsA sample of high school biology teachers in Fars province, Iran, filled out an investigator designed questionnaire including questions about their knowledge and attitude concerning “epilepsy”. There were 17 questions in the questionnaire. Nine questions addressed the knowledge and the rest were about attitude and perception.ResultsForty two teachers completed the questionnaires. More than two-thirds of the participants had a fairly desirable awareness about the definition; whereas, only approximately 40% knew something about the etiology and treatment of epilepsy. More than two-thirds of the participants had a positive attitude towards epilepsy; however, misconceptions and negative attitudes were observed.ConclusionEducational programs for biology teachers and also other teachers are necessary to improve their knowledge, attitude and perception about epilepsy.References Sander JW, Shorvon SD. Incidence and prevalence studies in epilepsy and their methodological problems: a review. J Neurol Neurosurg Psychiatry 1987;50:829-39. Saraceno B. The WHO world health report 2001 on mental health. Epidemiol Psychiatr Soc 2002;11(2:83-7. Kim MK, Cho KH, Shin J, Kim SJ. A study of public attitudes towards epilepsy in Kwang-Juarea. J Kor Neurol Assoc 1994;12:410-27. DiIorio C, Shafer PO, Letz R, Henry T, Schomer DL, Yeager K, etal. The association of stigma with self-management and perception of health care among adults with epilepsy. Epilepsy Behav 2003;4(3:259-67. Aziz H, Akhtar SW, Hasan KZ. Epilepsy in Pakistan: stigma and psychological problems: a population-based epidemiologic study. Epilepsia 1997

  7. Function of knowledge culture in the effectiveness of knowledge management procedures: A case study of a knowledge-based organization

    Mitra Dilmaghani; Fatima Fahimnia; Mohammad Aboyee Ardakan; Nader Naghshineh


    Effective aspects and factors on knowledge culture are identified. A model for explaining the relationship between knowledge culture and effectiveness of knowledge management procedures in a knowledge-based organization is presented. The study used a mixture of library and documentary studies, and exploratory mixed methods. First, the literature was reviewed to extract the effective aspects and factors on knowledge culture and the conceptual model was developed. Then, a questionnaire which wa...

  8. Investigating fundamentals of knowledge based economy using grounded theory

    Asadollah Kordnaeij; Mohsen Ebrahimi; Lotfollah Forozandeh Dehkordi; Ali Asghar Fani


    During the past few years, knowledge has played essential role for development of economy. As a result, a new concept of knowledge based economy has been developed. Knowledge based economy is responsible for creating wealth through exploring knowledge. In new millennium, knowledge has made significant impact on socio-economic changes. The proposed study of this paper performs an empirical investigation to determine fundamentals of knowledge based economy in Iran using grounded theory. The stu...

  9. Knowledge-based fragment binding prediction.

    Tang, Grace W; Altman, Russ B


    Target-based drug discovery must assess many drug-like compounds for potential activity. Focusing on low-molecular-weight compounds (fragments) can dramatically reduce the chemical search space. However, approaches for determining protein-fragment interactions have limitations. Experimental assays are time-consuming, expensive, and not always applicable. At the same time, computational approaches using physics-based methods have limited accuracy. With increasing high-resolution structural data for protein-ligand complexes, there is now an opportunity for data-driven approaches to fragment binding prediction. We present FragFEATURE, a machine learning approach to predict small molecule fragments preferred by a target protein structure. We first create a knowledge base of protein structural environments annotated with the small molecule substructures they bind. These substructures have low-molecular weight and serve as a proxy for fragments. FragFEATURE then compares the structural environments within a target protein to those in the knowledge base to retrieve statistically preferred fragments. It merges information across diverse ligands with shared substructures to generate predictions. Our results demonstrate FragFEATURE's ability to rediscover fragments corresponding to the ligand bound with 74% precision and 82% recall on average. For many protein targets, it identifies high scoring fragments that are substructures of known inhibitors. FragFEATURE thus predicts fragments that can serve as inputs to fragment-based drug design or serve as refinement criteria for creating target-specific compound libraries for experimental or computational screening. PMID:24762971

  10. Explanation-based knowledge acquisition of electronics

    Kieras, David E.


    This is the final report in a project that examined how knowledge of practical electronics could be acquired from materials similar to that appearing in electronics training textbooks, from both an artificial intelligence perspective and an experimental psychology perspective. Practical electronics training materials present a series of basic circuits accompanied by an explanation of how the circuit performs the desired function. More complex circuits are then explained in terms of these basic circuits. This material thus presents schema knowledge for individual circuit types in the form of explanations of circuit behavior. Learning from such material would thus consist of first instantiating any applicable schemas, and then constructing a new schema based on the circuit structure and behavior described in the explanation. If the basic structure of the material is an effective approach to learning, learning about a new circuit should be easier if the relevant schemas are available than not. This result was obtained for both an artificial intelligence system that used standard explanation-based learning mechanisms and with human learners in a laboratory setting, but the benefits of already having the relevant schemas were not large in these materials. The close examination of learning in this domain, and the structure of knowledge, should be useful to future cognitive analyses of training in technical domains.

  11. Toward E-Knowledge Based Complaint Management

    Abdelfatteh Triki


    Full Text Available Service failure and recovery is a well-established area of services research. Research has shown that service recovery is critically important from a managerial perspective in terms of maintaining customer relationships. Yet few firms excel at handling service failures. There is a growing number of managers who claim that customers tend to be dissatisfied with their service recovery effort. Their employees cannot improve service processes when they experience recovery situations and their companies still do not learn from service failure. [19] attribute the service recovery ineffectiveness to the competing interests of managing employees, customers and processes. We agree with their contention that to address these criticisms, complaint management must acknowledge and find new approaches to achieve consistency and to correct the misalignment of interests that can exist between the actions of the organisation and the needs of its customers and employees. We believe that search in the customer knowledge management literature represents one effective means to enhance a firm ability to implement a cohesive service recovery strategy.A comprehensive based knowledge creation system framework where the Socialization, Externalization, Combination and Internalization (SECI modes, and various ‘ba’ proposed by Nonaka and Konno are introduced for complaint management. Empirical research, involving a case study is presented to illustrate the proposed framework. This framework is believed to pave the way for e-knowledge based complaint management.

  12. A knowledge based software engineering environment testbed

    Gill, C.; Reedy, A.; Baker, L.


    The Carnegie Group Incorporated and Boeing Computer Services Company are developing a testbed which will provide a framework for integrating conventional software engineering tools with Artifical Intelligence (AI) tools to promote automation and productivity. The emphasis is on the transfer of AI technology to the software development process. Experiments relate to AI issues such as scaling up, inference, and knowledge representation. In its first year, the project has created a model of software development by representing software activities; developed a module representation formalism to specify the behavior and structure of software objects; integrated the model with the formalism to identify shared representation and inheritance mechanisms; demonstrated object programming by writing procedures and applying them to software objects; used data-directed and goal-directed reasoning to, respectively, infer the cause of bugs and evaluate the appropriateness of a configuration; and demonstrated knowledge-based graphics. Future plans include introduction of knowledge-based systems for rapid prototyping or rescheduling; natural language interfaces; blackboard architecture; and distributed processing

  13. Database systems for knowledge-based discovery.

    Jagarlapudi, Sarma A R P; Kishan, K V Radha


    Several database systems have been developed to provide valuable information from the bench chemist to biologist, medical practitioner to pharmaceutical scientist in a structured format. The advent of information technology and computational power enhanced the ability to access large volumes of data in the form of a database where one could do compilation, searching, archiving, analysis, and finally knowledge derivation. Although, data are of variable types the tools used for database creation, searching and retrieval are similar. GVK BIO has been developing databases from publicly available scientific literature in specific areas like medicinal chemistry, clinical research, and mechanism-based toxicity so that the structured databases containing vast data could be used in several areas of research. These databases were classified as reference centric or compound centric depending on the way the database systems were designed. Integration of these databases with knowledge derivation tools would enhance the value of these systems toward better drug design and discovery. PMID:19727614

  14. Predicting metabolic pathways from metabolic networks with limited biological knowledge

    Leung, HCM; Yiu, SM; Chin, FYL; Leung, SY; Xiang, CL


    Understanding the metabolism of new species (e.g. endophytic fungi that produce fuel) have tremendous impact on human lives. Based on predicted proteins and existing reaction databases, one can construct the metabolic network for the species. Next is to identify critical metabolic pathways from the network. Existing computational techniques identify conserved pathways based on multiple networks of related species, but have the following drawbacks. Some do not rely on additional information, s...


    SU Hai; JIANG Zuhua


    Due to the increasing amount and complexity of knowledge in product design, the knowledge map based on design process is presented as a tool to reuse product design process, promote the product design knowledge sharing. The relationship between design task flow and knowledge flow is discussed; A knowledge organizing method based on design task decomposition and a visualization method to support the knowledge retrieving and sharing in product design are proposed. And a knowledge map system to manage the knowledge in product design process is built with Visual C++ and SVG. Finally, a brief case study is provided to illustrate the construction and application of knowledge map in fuel pump design.

  16. Knowledge Based Design of Axial Flow Compressor

    Dinesh kumar.R


    Full Text Available In the aerospace industry with highly competitive market the time to design and delivery is shortening every day. Pressure on delivering robust product with cost economy is in demand in each development. Even though technology is older, it is new for each customer requirement and highly non-liner to fit one in another place. Gas turbine is considered one of a complex design in the aircraft system. It involves experts to be grouped with designers of various segments to arrive the best output. The time is crucial to achieve a best design and it needs knowledge automation incorporated with CAD/CAE tools. In the present work an innovative idea in the form of Knowledge Based Engineering for axial compressor is proposed, this includes the fundamental design of axial compressor integrated with artificial intelligence in the form of knowledge capturing and programmed with high level language (Visual Basis.Net and embedded into CATIA v5. This KBE frame work eases out the design and modeling of axial compressor design and produces 3D modeling for further flow simulation with fluid dynamic in Ansys-Fluent. Most of the aerospace components are developed through simulation driven product development and in this case it is established for axial compressor.

  17. Gestalteconomy: The economic bases of knowledge management

    Conventional economic analyses are based on dogmas that are frequently out of phase with reality. It is thus very difficult to introduce technology, technological innovation and technical progress correctly into all the theoretical constructions derived from the application of these principles. The same applies to the consideration of pollution and the depletion of natural resources. These difficult problems, which bedevil the definition of a sustainable development, find no satisfactory answer in these theoretical considerations. The consideration of Gestalteconomy helps to resolve these difficulties, in opening the door to the entrepreneurial practical management of knowledge. (author)

  18. Knowledge base of Nusselt number correlations

    This knowledge base was designed to identify various Nusselt Numbers given certain conditions and restrictions. The main criterion that was used in classifying them was the geometry of the flow. From these, the program then preceded to separate correlations by forced vs. free convection, laminar vs. turbulent flow, fully developed regimes vs. entrance regimes, constant wall temperature vs. constant wall flux, and different fluid types. Finally, the individual cases were classified according to particular ranges of Re, Pr, Pe, L/D ratio, etc. After this thorough search and elimination, the correct Nusselt Number was displayed

  19. Knowledge-based geometric modeling in construction

    Bonev, Martin; Hvam, Lars


    considerably high amount of their recourses is required for designing and specifying the majority of their product assortment. As design decisions are hereby based on knowledge and experience about behaviour and applicability of construction techniques and materials for a predefined design situation, smart...... tools need to be developed, to support these activities. In order to achieve a higher degree of design automation, this study proposes a framework for using configuration systems within the CAD environment together with suitable geometric modeling techniques on the example of a Danish manufacturer for...

  20. Adaptive Knowledge Management of Project-Based Learning

    Tilchin, Oleg; Kittany, Mohamed


    The goal of an approach to Adaptive Knowledge Management (AKM) of project-based learning (PBL) is to intensify subject study through guiding, inducing, and facilitating development knowledge, accountability skills, and collaborative skills of students. Knowledge development is attained by knowledge acquisition, knowledge sharing, and knowledge…

  1. Knowledge Innovation Mode Based on New Product Development Procedure

    Zhang Yi


    Knowledge classification based on new product development procedure The new product development procedure requires that each stage has necessary activity and output result,generally files,in fact these output results are coded product knowledge produced in each stage,also including product knowledge and process knowledge without coding,for instance the knowledge and experiences of project management,etc.

  2. Integrating biological knowledge into variable selection: an empirical Bayes approach with an application in cancer biology

    Hill Steven M; Neve Richard M; Bayani Nora; Kuo Wen-Lin; Ziyad Safiyyah; Spellman Paul T; Gray Joe W; Mukherjee Sach


    Abstract Background An important question in the analysis of biochemical data is that of identifying subsets of molecular variables that may jointly influence a biological response. Statistical variable selection methods have been widely used for this purpose. In many settings, it may be important to incorporate ancillary biological information concerning the variables of interest. Pathway and network maps are one example of a source of such information. However, although ancillary informatio...

  3. Is Biology based on Physics?

    Goradia, Shantilal


    The equation on Boltsmann's tomb is S = K log W, giving 137 = 10E60 where 10E60 closely stands for the age of the universe in Plank times. We wish we could add ``137 = 10E60'' on his tomb as a contribution leading physics towards information in biology as explained in our book ``Quantum Consciousness - the Road to Reality.'' (1) We draft our speculation that such a step may explain the underlying physical cause for mutations. Tiny immeasurable and slow changes well beyond the tenth digit of fine structure constant may suffice to change the information system in constituent particles of nucleotides with their external effects forcing changes in the genetic code with successful changes resulting into mutations. (2) Our quantum mechanical published derivation of the strong coupling implies gravity as a cumulative effect of quantum mechanical particles further implying that the universal constant of gravity (G) can not be constant everywhere. (1) and (2) put together should remove Darwin's confusion about the constancy of gravity. Moving planets and Sunstorms should also cause changes in G on earth unnoticeable to mankind, but large enough to have an impact on the internal particles of nucleotides which should implicitly have an external effect on the genetic code per our theory.

  4. A display to support knowledge based behavior

    This paper reports on a computerized display that has been created for the Experimental Breeder Reactor II that incorporates information from plant sensors in a thermodynamic model display. The display is designed to provide an operator with an overall view of the plant process as a heat engine. The thermodynamics of the plant are depicted through the use of iconic figures, animated by plant signals, that are related to the major plant components and systems such as the reactor, intermediate heat exchanger, secondary system, evaporators, superheaters, steam system, steam drum, and turbine-generator. This display supports knowledge based reasoning for the operator as well as providing data for the traditional rule and skill based behavior, and includes side benefits such as inherent signal validation

  5. Knowledge and Attitude Towards Epilepsy Among Biology Teachers in Fars Province, Iran

    Ali Akbar ASADI-POOYA


    Full Text Available ObjectiveThis study investigates the awareness and perception on “epilepsy” amongst biology teachers in Fars province, Iran.Materials & MethodsA sample of high school biology teachers in Fars province, Iran, filled out an investigator designed questionnaire including questions about their knowledge and attitude concerning “epilepsy”. There were 17 questions in the questionnaire. Nine questions addressed the knowledge and the rest were about attitude and perception.ResultsForty two teachers completed the questionnaires. More than two-thirds of the participants had a fairly desirable awareness about the definition; whereas, only approximately 40% knew something about the etiology and treatment of epilepsy. More than two-thirds of the participants had a positive attitude towards epilepsy; however, misconceptions and negative attitudes were observed.ConclusionEducational programs for biology teachers and also other teachers are necessary to improve their knowledge, attitude and perception about epilepsy.

  6. Transition to knowledge-based economy in Saudi Arabia

    Nour, S.


    This paper discusses the progress in transition to knowledge-based economy in Saudi Arabia. As for the methodology, this paper uses updated secondary data obtained from different sources. It uses both descriptive and comparative approaches and uses the OECD definition of knowledge-based economy and the World Bank Knowledge Index (KI) and Knowledge Economy Index (KEI) and other indicators often used in the international literature to examine progress in transition to a knowledge-based economy ...

  7. A convenient dichotomy: critical eyes on the limits to biological knowledge

    Milne, Catherine


    In The Secret Identity of a Biology Textbook: straight and naturally sexed, Jesse Bazzul and Heather Sykes conduct a case study of a biology textbook as an oppressive instructional material. Using queer theory they explore how the text of the biology textbook produces "truths" about sex, gender, and sexuality. Their analysis is complemented by the Forum papers by Jay Lemke and Francis Broadway who broaden the analysis examining the way that what counts as knowledge in science is a political decision while also encouraging authors, including Bazzul and Sykes, to also look critically at their own theoretical lenses. In this paper I pull together their ideas while exploring cultural contexts for a more nuanced representation of biological knowledge and the politics of what it means to know science.

  8. Mapping biological ideas: Concept maps as knowledge integration tools for evolution education

    Schwendimann, Beat Adrian

    -specific form of concept map, called Knowledge Integration Map (KIM), which aims to help learners connect ideas across levels (for example, genotype and phenotype levels) towards an integrated understanding of evolution. Using a design-based research approach (Brown, 1992; Cobb et al., 2003), three iterative studies were implemented in ethically and economically diverse public high schools classrooms using the web-based inquiry science environment (WISE) (Linn et al., 2003; Linn et al., 2004). Study 1 investigates concept maps as generative assessment tools. Study 1A compares the concept map generation and critique process of biology novices and experts. Findings suggest that concept maps are sensitive to different levels of knowledge integration but require scaffolding and revision. Study 1B investigates the implementation of concept maps as summative assessment tools in a WISE evolution module. Results indicate that concept maps can reveal connections between students' alternative ideas of evolution. Study 2 introduces KIMs as embedded collaborative learning tools. After generating KIMs, student dyads revise KIMs through two different critique activities (comparison against an expert or peer generated KIM). Findings indicate that different critique activities can promote the use of different criteria for critique. Results suggest that the combination of generating and critiquing KIMs can support integrating evolution ideas but can be time-consuming. As time in biology classrooms is limited, study 3 distinguishes the learning effects from either generating or critiquing KIMs as more time efficient embedded learning tools. Findings suggest that critiquing KIMs can be more time efficient than generating KIMs. Using KIMs that include common alternative ideas for critique activities can create genuine opportunities for students to critically reflect on new and existing ideas. Critiquing KIMs can encourage knowledge integration by fostering self-monitoring of students' learning

  9. Verbal Final Exam in Introductory Biology Yields Gains in Student Content Knowledge and Longitudinal Performance

    Luckie, Douglas B.; Rivkin, Aaron M.; Aubry, Jacob R.; Marengo, Benjamin J.; Creech, Leah R.; Sweeder, Ryan D.


    We studied gains in student learning over eight semesters in which an introductory biology course curriculum was changed to include optional verbal final exams (VFs). Students could opt to demonstrate their mastery of course material via structured oral exams with the professor. In a quantitative assessment of cell biology content knowledge, students who passed the VF outscored their peers on the medical assessment test (MAT), an exam built with 40 Medical College Admissions Test (MCAT) quest...

  10. Survey on Agricultural Biological Resources and Traditional Cultural Knowledge of Hani People in Yunnan

    Zhang, Liqin; Luo, Hong; LONG, Wenjie; LEI, Yongtao; Cai, Qing; Lan, Mei; Zhong, Li


    In 2007-2008, a systematic survey, collection and arrangement was carried out for agricultural biological resources and traditional cultural knowledge of Hani People in 8 counties, 15 towns, and 23 village committees of Yunnan Province. A total of 299 samples were obtained about agricultural biological resources related to production and living of Hani People. According to purpose of utilization, samples were divided into grain crops, medicinal plants, vegetables, fruit trees, and oil crops, ...

  11. Structuring and extracting knowledge for the support of hypothesis generation in molecular biology

    van Hage Willem; Katrenko Sophia; Meij Edgar; Schuemie Martijn; Gibson Andrew P; Marshall M Scott; Roos Marco; Krommydas Konstantinos; Adriaans Pieter W


    Abstract Background Hypothesis generation in molecular and cellular biology is an empirical process in which knowledge derived from prior experiments is distilled into a comprehensible model. The requirement of automated support is exemplified by the difficulty of considering all relevant facts that are contained in the millions of documents available from PubMed. Semantic Web provides tools for sharing prior knowledge, while information retrieval and information extraction techniques enable ...

  12. Knowledge-based approach to system integration

    Blokland, W.; Krishnamurthy, C.; Biegl, C.; Sztipanovits, J.


    To solve complex problems one can often use the decomposition principle. However, a problem is seldom decomposable into completely independent subproblems. System integration deals with problem of resolving the interdependencies and the integration of the subsolutions. A natural method of decomposition is the hierarchical one. High-level specifications are broken down into lower level specifications until they can be transformed into solutions relatively easily. By automating the hierarchical decomposition and solution generation an integrated system is obtained in which the declaration of high level specifications is enough to solve the problem. We offer a knowledge-based approach to integrate the development and building of control systems. The process modeling is supported by using graphic editors. The user selects and connects icons that represent subprocesses and might refer to prewritten programs. The graphical editor assists the user in selecting parameters for each subprocess and allows the testing of a specific configuration. Next, from the definitions created by the graphical editor, the actual control program is built. Fault-diagnosis routines are generated automatically as well. Since the user is not required to write program code and knowledge about the process is present in the development system, the user is not required to have expertise in many fields.

  13. Knowledge Based Society,an outcome of Social Capital Linking

    Maciel Sanchez, Isaac


    he present project analyses the relationship between knowledge and society. Specialists mention the relevance of knowledge in the current post-industrial era, coining it differently and according to their specific school of thought or ideology (economics, sociology, etc) as Knowledge Economy, Knowledge Society, or Knowledge Based Society. Even International Institutions such as the European Commission, the UNESCO or the World Bank, have pointed the relevance of knowledge in the economic devel...

  14. Combination of Neuro-Fuzzy Network Models with Biological Knowledge for Reconstructing Gene Regulatory Networks

    Guixia Liu; Lei Liu; Chunyu Liu; Ming Zheng; Lanying Su; Chunguang Zhou


    Inferring gene regulatory networks from large-scale expression data is an important topic in both cellular systems and computational biology. The inference of regulators might be the core factor for understanding actual regulatory conditions in gene regulatory networks, especially when strong regulators do work significantly, in this paper, we propose a novel approach based on combining neuro-fuzzy network models with biological knowledge to infer strong regulators and interrelated fuzzy rules. The hybrid neuro-fuzzy architecture can not only infer the fuzzy rules, which are suitable for describing the regulatory conditions in regulatory networks, but also explain the meaning of nodes and weight value in the neural network. It can get useful rules automatically without factitious judgments. At the same time, it does not add recursive layers to the model, and the model can also strengthen the relationships among genes and reduce calculation. We use the proposed approach to reconstruct a partial gene regulatory network of yeast. The results show that this approach can work effectively.

  15. Knowledge Governance in Project-Based Organizations

    Pemsel, Sofia; Wiewiora, Anna; Müller, Ralf;

    definition of KG in PBOs, a conceptual framework to investigate KG and a methodological framework for empirical inquiry into KG in PBO settings. Our definition highlights the contingent nature of KG processes in relation to their organizational context. The conceptual framework addresses macro- and micro......This paper conceptualizes knowledge governance (KG) in project-based organizations (PBOs) and its methodological approaches for empirical investigation. Three key contributions towards a multi-faceted view of KG and an understanding of KG in PBOs are advanced. These contributions include a......-level elements of KG and their interaction. The methodological framework proposes five different research approaches, structured by differentiation and integration of various ontological and epistemological stances. Together these contributions provide a novel platform for understanding KG in PBOs and developing...

  16. Function of knowledge culture in the effectiveness of knowledge management procedures: A case study of a knowledge-based organization

    Mitra Dilmaghani


    Full Text Available Effective aspects and factors on knowledge culture are identified. A model for explaining the relationship between knowledge culture and effectiveness of knowledge management procedures in a knowledge-based organization is presented. The study used a mixture of library and documentary studies, and exploratory mixed methods. First, the literature was reviewed to extract the effective aspects and factors on knowledge culture and the conceptual model was developed. Then, a questionnaire which was validated through eliciting the comments of experts and examining the status of knowledge management in the organization was distributed to the researchers who were randomly selected to be included in the sample. The collected data were examined through AMOS and SPSS software. The possible relationship between the components of the model was investigated through posing five hypotheses and correlation coefficient test. The results of structural equation modeling demonstrated a significant positive relationship between contextual factors and aspects of knowledge culture and between knowledge culture and the knowledge management effectiveness. Evaluating the variables of the conceptual model revealed that staff members’ characteristics, information technology and job characteristics would make a significant positive impact on knowledge creation and knowledge sharing. However, these factors had no significant influence on knowledge cooperation and knowledge learning.


    PLUMB Ion; ZAMFIR Andreea


    The topic of the knowledge-based society and its implications on management is highly debated nowadays. Therefore, the aim of this study is to identify the logical connections between the knowledge-based society and the managerial revolution. The findings of this study reveal that the knowledge- based society and, more specifically, the knowledge-based economy, along with their main features and requirements regarding people’s competences and skills, have a major influence on management, whet...

  18. Behaviour-based Knowledge Systems: An Epigenetic Path from Behaviour to Knowledge

    Gershenson, Carlos


    In this paper we expose the theoretical background underlying our current research. This consists in the development of behaviour-based knowledge systems, for closing the gaps between behaviour-based and knowledge-based systems, and also between the understandings of the phenomena they model. We expose the requirements and stages for developing behaviour-based knowledge systems and discuss their limits. We believe that these are necessary conditions for the ...

  19. Study on Knowledge -based Intelligent Fault Diagnosis of Hydraulic System

    Xuexia Liu


    Full Text Available A general framework of hydraulic fault diagnosis system was studied. It consisted of equipment knowledge bases, real-time databases, fusion reasoning module, knowledge acquisition module and so on. A tree-structure model of fault knowledge was established. Fault nodes knowledge was encapsulated by object-oriented technique. Complete knowledge bases were made including fault bases and diagnosis bases. It could describe the fault positions, the structure of fault, cause-symptom relationships, diagnosis principles and other knowledge. Taking the fault of left and right lifting oil cylinder out of sync for example, the diagnostic results show that the methods were effective.




    This paper aims to present the knowledge based economy as a pillar of the knowledge society, due to the fact that in the past decades there has been a series of transitions of the global economy from the development based on traditional factors to a knowledge based economy, in which intangible goods are of vital importance.

  1. Product Modeling Based on Knowledge Fusion in Virtual Environment

    邹湘军; 孙健; 何汉武


    Following researches on the knowledge-based product design, product modeling based on knowledge fusion is studied in a virtual environment. Knowledge fusion is the energy sources of product innovation designs. Because a knowledge representation method is the main content of knowledge fusion, production rule way, semantic network, predicate, object-oriented and case-based representations are discussed. Using agents with object-oriented method, the knowledge can be represented as a set. The product knowledge set is divided into two subset: text knowledge and knowledge of engineering graphics that is a different form. Manipulation of the subset knowledge and fusion method is described. The paper also describes a six-tuple function in an agent data structure. A virtual environment computation model is proposed, and a practical example given.

  2. Advanced software development workstation. Knowledge base design: Design of knowledge base for flight planning application

    Izygon, Michel E.


    The development process of the knowledge base for the generation of Test Libraries for Mission Operations Computer (MOC) Command Support focused on a series of information gathering interviews. These knowledge capture sessions are supporting the development of a prototype for evaluating the capabilities of INTUIT on such an application. the prototype includes functions related to POCC (Payload Operation Control Center) processing. It prompts the end-users for input through a series of panels and then generates the Meds associated with the initialization and the update of hazardous command tables for a POCC Processing TLIB.

  3. 'Medical Knowledge' and 'Tradition' of Colonial Korea: Focused on Kudo's "Gynecology"-based Knowledge.

    Hong, Yang Hee


    This article attempts to illuminate the ways in which Kudo's medical knowledge based on 'gynecological science' constructed the cultural 'traditions' of colonial Korea. Kudo appears to have been quite an influential figure in colonial Korea in that his writings on the relationship between women's crime, gynecological science and the Chosŏn society granted a significant amount of intellectual authority. Here, I examine Kudo's position within colonial Korea as a producer and propagator of medical knowledge, and then see how women's bodies were understood according to his gynecological knowledge. It also traces the ways in which Kudo's gynecological knowledge represents Chosŏn society and in turn invents the 'traditions' of Chosŏn. Kudo's knowledge of "gynecology" which had been formed while it traveled the states such as Japan, Germany and France served as an important reference for his representation of colonial Korean society. Kudo was a proponent of biological evolution, particularly the rules of 'atavism' put forth by the criminal anthropologist Cesare Lombroso, and argued that an unique social environment caused 'alteration of sexual urges' and primitive cruelty in Chosŏn women. According to Kudo, The social environment was none other than the practice of 'early marriage,' which went against the physiology of women. To Kudo, 'early marriage' was an old 'tradition' of Chosŏn and the cause of heinous crimes, as well as an unmistakable indicator of both the primitiveness and savageness of Chosŏn. While Lombroso considered personal factors such as stress as the cause of women's crimes, Kudo saw Chosŏn women's crimes as a national characteristic. Moreover, he compared the occurrence rate of husband murders by provinces, based on which he categorized the northern population of Chosŏn as barbaric Manchurian and the southern population as the superior Japanese, a combination of racism and scientific knowledge. Kudo's writings provide an insight into the

  4. Knowledge-Based Classification in Automated Soil Mapping



    A machine-learning approach was developed for automated building of knowledge bases for soil resourcesmapping by using a classification tree to generate knowledge from training data. With this method, buildinga knowledge base for automated soil mapping was easier than using the conventional knowledge acquisitionapproach. The knowledge base built by classification tree was used by the knowledge classifier to perform thesoil type classification of Longyou County, Zhejiang Province, China using Landsat TM bi-temporal imagesand GIS data. To evaluate the performance of the resultant knowledge bases, the classification results werecompared to existing soil map based on a field survey. The accuracy assessment and analysis of the resultantsoil maps suggested that the knowledge bases built by the machine-learning method was of good quality formapping distribution model of soil classes over the study area.

  5. Competitiveness in the Knowledge-Based Economy

    Stefan NEDELEA; Laura Adriana PAUN


    In a globalizing economy, competitiveness means information and know-how rather than capital and physical assets. The function of knowledge management is therefore to allow organizations to leverage their information resources and knowledge assets by remembering and applying experience. An organization’s ability to compete on the market is increasingly seen as depending on the skills and knowledge of its employees, regarded as intellectual capital, and on its capacity to preserve and use as m...

  6. Explicating Knowledge-based Competitive Advantage

    Karim Moustaghfir


    Purpose – Explaining how knowledge assets provide firms with a competitive advantage and show how organizational capabilities have the potential to produce long-term superior performance. Paper Category – Research Paper and Case Study. Design/Methodology/Approach – Systematic literature review and in-depth single case study. Findings – Knowledge assets through different learning mechanisms and effective knowledge management processes are bundled, linked, incorporated, converted, organized, an...

  7. Conscious knowledge of learning: accessing learning strategies in a final year high school biology class

    Conner, Lindsey; Gunstone, Richard


    This paper reports on a qualitative case study investigation of the knowledge and use of learning strategies by 16 students in a final year high school biology class to expand their conscious knowledge of learning. Students were provided with opportunities to engage in purposeful inquiry into the biological, social and ethical aspects of cancer. A constructivist approach was implemented to access prior content and procedural knowledge in various ways. Students were encouraged to develop evaluation of their learning skills independently through activities that promoted metacognition. Those students who planned and monitored their work produced essays of higher quality. The value and difficulties of promoting metacognitive approaches in this context are discussed, as well as the idea that metacognitive processes are difficult to research, because they have to be conscious in order to be identified by the learner, thereby making them accessible to the researcher.

  8. Integration of an object knowledge base into a medical workstation.

    Timmers, T.; van Mulligen, E. M.; van den Heuvel, F.


    A simple, yet powerful, knowledge base and its development environment is described that can act as a "knowledge server", integrated into a medical workstation. In many areas, such an integration of a knowledge base with other modules and systems is required, but difficult or impossible to achieve with existing commercial development shells. Three applications of the knowledge base are described: a controlled vocabulary for the classification of Congenital Heart Diseases, an extended data mod...

  9. Prototype Biology-Based Radiation Risk Module Project

    Terrier, Douglas; Clayton, Ronald G.; Patel, Zarana; Hu, Shaowen; Huff, Janice


    Biological effects of space radiation and risk mitigation are strategic knowledge gaps for the Evolvable Mars Campaign. The current epidemiology-based NASA Space Cancer Risk (NSCR) model contains large uncertainties (HAT #6.5a) due to lack of information on the radiobiology of galactic cosmic rays (GCR) and lack of human data. The use of experimental models that most accurately replicate the response of human tissues is critical for precision in risk projections. Our proposed study will compare DNA damage, histological, and cell kinetic parameters after irradiation in normal 2D human cells versus 3D tissue models, and it will use a multi-scale computational model (CHASTE) to investigate various biological processes that may contribute to carcinogenesis, including radiation-induced cellular signaling pathways. This cross-disciplinary work, with biological validation of an evolvable mathematical computational model, will help reduce uncertainties within NSCR and aid risk mitigation for radiation-induced carcinogenesis.

  10. Knowledge Economy Factors and the Development of Knowledge-based Economy

    Dragomir Sundać; Irena Fatur Krmpotić


    The aim of this paper is to identify the various knowledge economy factors that have an impact on the achieved economic growth of national economies. This paper argues that there is no single scenario for building a knowledge-based economy. It utilizes variables of the knowledge economy, collected according to the Knowledge Assessment Methodology (KAM - benchmarking tool of the World Bank), on a sample of 118 countries. The countries are divided in three income groups according to GDP per cap...

  11. From conventional software based systems to knowledge based systems

    Even if todays nuclear power plants have a very good safety record, there is a continuous search for still improving safety. One direction of this effort address operational safety, trying to improve the handling of disturbances and accidents partly by further automation, partly by creating a better control room environment, providing the operator with intelligent support systems to help in the decision making process. Introduction of intelligent computerised operator support systems has proved to be an efficient way of improving the operators performance. A number of systems have been developed worldwide, assisting in tasks like process fault detection and diagnosis, selection and implementation of proper remedial actions. Unfortunately, the use of Knowledge Based Systems (KBSs), introduces a new dimension to the problem of the licensing process. KBSs, despite the different technology employed, are still nothing more than a computer program. Unfortunately, quite a few people building knowledge based systems seem to ignore the many good programming practices that have evolved over the years for producing traditional computer programs. In this paper the author will try to point out similarities and differences between conventional software based systems, and knowledge based systems, introducing also the concept of model based reasoning. (orig.) (25 refs., 2 figs.)




    Knowledge has the greatest value, the most human contribution, the greatest relevance to decision processes and actions and the greatest impact on specific situations or contexts. In an organizational context, all new knowledge comes from people. Some knowledge is included in organizational processes, structures and technologies. Recently, knowledge management was remitted to the domain of organizations whose primary business was to sell knowledge-based goods and products. Now, it is rapidly ...

  13. Building a Knowledge Experience Base for Facilitating Innovation

    Pasquale Ardimento; Vito Nicola Convertini; Giuseppe Visaggio


    This paper presents a framework aimed at supporting knowledge transferring inside and outside an organization for innovation purposes. For this goal, the authors propose a Knowledge Experience Base (KEB), which collects Knowledge Experience Packages (KEP), to support the formalization and packaging of knowledge and experience of innovation stakeholders, encouraging gradual explanation of tacit information of bearers of knowledge to facilitate the transfer, minimizing costs and risks.

  14. Enhancing SAT Based Planning with Landmark Knowledge

    Elffers, J.; Konijnenberg, D.; Walraven, E.M.P.; Spaan, M.T.J.


    Several approaches exist to solve Artificial Intelligence planning problems, but little attention has been given to the combination of using landmark knowledge and satisfiability (SAT). Landmark knowledge has been exploited successfully in the heuristics of classical planning. Recently it was also s

  15. Knowledge based systems for condition monitoring

    McDonald, J.R.; Burt, G.M.; Moyes, A.


    A key issue in the operation of power system plant is deriving maximum financial benefit while staying within technical, contractual and regulatory constraints. Moreover, the capital investment required for much power system plant necessitates high levels of plant availability to make a reasonable rate-of-return. Thus, the minimisation of operational costs resulting from unplanned plant outages, unnecessary maintenance and under-utilisation of plant capabilities has become a core objective of power system plant operation. Rationalisation of power system control functions has resulted in the use of centralised control rooms from which large and complex power systems are operated. Extensive measurement, monitoring and control systems have been developed which provide operators with data from which power system plant behaviour can be evaluated. However, in the event of a serious operational incident, significant amounts of data are generated. Under such circumstances it has been found that operators are inhibited in assessing the situation, and hence the effectiveness of the subsequent operational response can be reduced. The role of knowledge based systems (KBSs) in condition monitoring is to support operational decision making through the provision of timely and focused information. (Author)

  16. IGENPRO knowledge-based operator support system

    Research and development is being performed on the knowledge-based IGENPRO operator support package for plant transient diagnostics and management to provide operator assistance during off-normal plant transient conditions. A generic thermal-hydraulic (T-H) first-principles approach is being implemented using automated reasoning, artificial neural networks and fuzzy logic to produce a generic T-H system-independent/plant-independent package. The IGENPRO package has a modular structure composed of three modules: the transient trend analysis module PROTREN, the process diagnostics module PRODIAG and the process management module PROMANA. Cooperative research and development work has focused on the PRODIAG diagnostic module of the IGENPRO package and the operator training matrix of transients used at the Braidwood Pressurized Water Reactor station. Promising simulator testing results with PRODIAG have been obtained for the Braidwood Chemical and Volume Control System (CVCS), and the Component Cooling Water System. Initial CVCS test results have also been obtained for the PROTREN module. The PROMANA effort also involves the CVCS. Future work will be focused on the long-term, slow and mild degradation transients where diagnoses of incipient T-H component failure prior to forced outage events is required. This will enhance the capability of the IGENPRO system as a predictive maintenance tool for plant staff and operator support


    Iulia MÃRIEª


    The main objective of the paper is to highlight the characteristics of knowledge-based systems and to present the concept „community of practice” in the context of knowledge-based economy. The paper addresses the new trends and challenges of knowledge dynamics within communities of practice and examines the emergence of this type of communities.

  18. Occupational biological risk knowledge and perception: results from a large survey in Rome, Italy

    Maria De Giusti


    Full Text Available BACKGROUND: A cross-sectional survey on knowledge and perception of occupational biological risk among workers in several occupations was carried out in the industrial area of Rome. METHODS: The study was carried out in the period of March-April 2010 using a questionnaire with 33 items on the following areas: a socio-demographic data; b perception of the biological risks in ordinary occupational activity; c knowledge about biological risks; d biological risks in the working environment. The questionnaire was submitted to a convenience sample of workers of an industrial area in Southern Rome. RESULTS: 729 participants entered the study from the following work activities: food, catering, service, farming and breeding, healthcare, school and research (males 57.2%; mean age 37.4 years, SD = 10.9. Significant associations were found between different activity areas with respect to the relevance of the biological risk (p = 0.044 and the perception of the biological risk (p < 0.001. With respect to vehicles of infectious agents, the highest percentages of the most common biological risk exposures were: air and physical contact for the catering and food group, 66.7% and 61.90% respectively; air and blood for the health and research group, with 73.50% and 57.00% respectively; and physical contact and blood for the service group, 63.10 % and 48.30%. Significant difference of proportions were found about the prevalent effect caused by the biological agents was the occurrence of infectious diseases (59.90% food group, 91.60% health and research and 79.30% service group (p < 0.001. The perception of knowledge resulted in a good rank (sufficient, many or complete in the food and catering group, 78.3% with significant difference compared to other professions (p < 0.001. CONCLUSIONS: All participants show good knowledge the effects induced by biological agents and it is significant that almost half of the respondents are aware of the risks concerning allergies

  19. Knowledge Base Grid: A Generic Grid Architecture for Semantic Web

    WU ZhaoHui(吴朝晖); CHEN HuaJun(陈华钧); XU JieFeng(徐杰锋)


    The emergence of semantic web will result in an enormous amount of knowledge base resources on the web. In this paper, a generic Knowledge Base Grid Architecture (KB-Grid)for building large-scale knowledge systems on the semantic web is presented. KB-Grid suggests a paradigm that emphasizes how to organize, discover, utilize, and manage web knowledge base resources. Four principal components are under development: a semantic browser for retrieving and browsing semantically enriched information, a knowledge server acting as the web container for knowledge, an ontology server for managing web ontologies, and a knowledge base directory server acting as the registry and catalog of KBs. Also a referential model of knowledge service and the mechanisms required for semantic communication within KB-Grid are defined. To verify the design rationale underlying the KB-Grid, an implementation of Traditional Chinese Medicine(TCM) is described.

  20. Case-based reasoning: The marriage of knowledge base and data base

    Pulaski, Kirt; Casadaban, Cyprian


    The coupling of data and knowledge has a synergistic effect when building an intelligent data base. The goal is to integrate the data and knowledge almost to the point of indistinguishability, permitting them to be used interchangeably. Examples given in this paper suggest that Case-Based Reasoning is a more integrated way to link data and knowledge than pure rule-based reasoning.

  1. Knowledge-based Expressive Technologies within Cloud Computing Environments

    Sergey V. Kovalchuk; Smirnov, Pavel A.; Knyazkov, Konstantin V.; Zagarskikh, Alexander S.; Boukhanovsky, Alexander V.


    Presented paper describes the development of comprehensive approach for knowledge processing within e-Sceince tasks. Considering the task solving within a simulation-driven approach a set of knowledge-based procedures for task definition and composite application processing can be identified. This procedures could be supported by the use of domain-specific knowledge being formalized and used for automation purpose. Within this work the developed conceptual and technological knowledge-based to...

  2. Splitting and Updating Hybrid Knowledge Bases (Extended Version)

    Slota, Martin; Leite, João; Swift, Terrance


    Over the years, nonmonotonic rules have proven to be a very expressive and useful knowledge representation paradigm. They have recently been used to complement the expressive power of Description Logics (DLs), leading to the study of integrative formal frameworks, generally referred to as hybrid knowledge bases, where both DL axioms and rules can be used to represent knowledge. The need to use these hybrid knowledge bases in dynamic domains has called for the development of update operators, ...

  3. The representation of knowledge within model-based control systems

    Representation of knowledge in artificially intelligent systems is discussed. Types of knowledge that might need to be represented in AI systems are listed, and include knowledge about objects, events, knowledge about how to do things, and knowledge about what human beings know (meta-knowledge). The use of knowledge in AI systems is discussed in terms of acquiring and retrieving knowledge and reasoning about known facts. Different kinds of reasonings or representations are ghen described with some examples given. These include formal reasoning or logical representation, which is related to mathematical logic, production systems, which are based on the idea of condition-action pairs (production), procedural reasoning, which uses pre-formed plans to solve problems, frames, which provide a structure for representing knowledge in an organized manner, direct analogical representations, which represent knowledge in such a manner that permits some observation without deduction

  4. Education Knowledge System Combination Model Based on the Components

    CHEN Lei; LI Dehua; LI Xiaojian; WU Chunxiang


    Resources are the base and core of education information, but current web education resources have no structure and it is still difficult to reuse them and make them can be self assembled and developed continually. According to the knowledge structure of course and text, the relation among knowledge points, knowledge units from three levels of media material, we can build education resource components, and build TKCM (Teaching Knowledge Combination Model) based on resource components. Builders can build and assemble knowledge system structure and make knowledge units can be self assembled, thus we can develop and consummate them continually. Users can make knowledge units can be self assembled and renewed, and build education knowledge system to satisfy users' demand under the form of education knowledge system.

  5. An Ontology-based Knowledge Management System for Industry Clusters

    Sureephong, Pradorn; Ouzrout, Yacine; Bouras, Abdelaziz


    Knowledge-based economy forces companies in the nation to group together as a cluster in order to maintain their competitiveness in the world market. The cluster development relies on two key success factors which are knowledge sharing and collaboration between the actors in the cluster. Thus, our study tries to propose knowledge management system to support knowledge management activities within the cluster. To achieve the objectives of this study, ontology takes a very important role in knowledge management process in various ways; such as building reusable and faster knowledge-bases, better way for representing the knowledge explicitly. However, creating and representing ontology create difficulties to organization due to the ambiguity and unstructured of source of knowledge. Therefore, the objectives of this paper are to propose the methodology to create and represent ontology for the organization development by using knowledge engineering approach. The handicraft cluster in Thailand is used as a case stu...

  6. A framework for knowledge acquisition, representation and problem-solving in knowledge-based planning

    Martinez-Bermudez, Iliana

    This research addresses the problem of developing planning knowledge-based applications. In particular, it is concerned with the problems of knowledge acquisition and representation---the issues that remain an impediment to the development of large-scale, knowledge-based planning applications. This work aims to develop a model of planning problem solving that facilitates expert knowledge elicitation and also supports effective problem solving. Achieving this goal requires determining the types of knowledge used by planning experts, the structure of this knowledge, and the problem-solving process that results in the plan. While answering these questions it became clear that the knowledge structure, as well as the process of problem solving, largely depends on the knowledge available to the expert. This dissertation proposes classification of planning problems based on their use of expert knowledge. Such classification can help in the selection of the appropriate planning method when dealing with a specific planning problem. The research concentrates on one of the identified classes of planning problems that can be characterized by well-defined and well-structured problem-solving knowledge. To achieve a more complete knowledge representation architecture for such problems, this work employs the task-specific approach to problem solving. The result of this endeavor is a task-specific methodology that allows the representation and use of planning knowledge in a structural, consistent manner specific to the domain of the application. The shell for building a knowledge-based planning application was created as a proof of concept for the methodology described in this dissertation. This shell enabled the development of a system for manufacturing planning---COMPLAN. COMPLAN encompasses knowledge related to four generic techniques used in composite material manufacturing and, given the description of the composite part, creates a family of plans capable of producing it.

  7. Knowledge Bases and the Geography of Innovation

    Martin, Roman


    Despite the ongoing globalisation of economic activities, innovation does not take place randomly distributed over space, but concentrates in certain locations. A central argument to explain the spatial concentration of innovation activities lies in the ability of geographical proximity to facilitate interactive learning and knowledge exchange, which in turn is seen as an important driver for regional growth and prosperity. Intensive knowledge sharing within the regional milieu is considered ...

  8. Integration of aquatic ecology and biological oceanographic knowledge for development of area-based eutrophication assessment criteria leading to water resource remediation and utilization management: a case study in Tha Chin, the most eutrophic river of Thailand.

    Meksumpun, Charumas; Meksumpun, Shettapong


    This research was carried out in Tha Chin Watershed in the central part of Thailand with attempts to apply multidisciplinary knowledge for understanding ecosystem structure and response to anthropogenic pollution and natural impacts leading to a proposal for an appropriate zonation management approach for sustainable utilization of the area. Water quality status of the Tha Chin River and Estuary had been determined by analyzing ecological, hydrological, and coastal oceanographic information from recent field surveys (during March 2006 to November 2007) together with secondary data on irrigation, land utilization, and socio-economic status.Results indicated that the Tha Chin River and Estuary was eutrophic all year round. Almost 100% of the brackish to marine areas reflected strongly hypertrophic water condition during both dry and high-loading periods. High NH(4)(+) and PO(4)(3-) loads from surrounding agricultural land use, agro-industry, and community continuously flew into the aquatic environment. Deteriorated ecosystem was clearly observed by dramatically low DO levels (ca 1 mg/l) in riverine to coastal areas and Noctiluca and Ceratium red tide outbreaks occurred around tidal front closed to the estuary. Accordingly, fishery resources were significantly decreased. Some riverine benthic habitats became dominated by deposit-feeding worms e.g. Lumbriculus, Branchiura, and Tubifex, while estuarine benthic habitats reflected succession of polychaetes and small bivalves. Results on analysis on integrated ecosystem responses indicated that changing functions were significantly influenced by particulates and nutrients dynamics in the system.Based on the overall results, the Tha Chin River and Estuary should be divided into 4 zones (I: Upper freshwater zone; II: Middle freshwater zone; III Lower freshwater zone; and IV: Lowest brackish to marine zone) for further management schemes on water remediation. In this study, the importance of habitat morphology and water flow

  9. A Knowledge-Based System Developer for aerospace applications

    Shi, George Z.; Wu, Kewei; Fensky, Connie S.; Lo, Ching F.


    A prototype Knowledge-Based System Developer (KBSD) has been developed for aerospace applications by utilizing artificial intelligence technology. The KBSD directly acquires knowledge from domain experts through a graphical interface then builds expert systems from that knowledge. This raises the state of the art of knowledge acquisition/expert system technology to a new level by lessening the need for skilled knowledge engineers. The feasibility, applicability , and efficiency of the proposed concept was established, making a continuation which would develop the prototype to a full-scale general-purpose knowledge-based system developer justifiable. The KBSD has great commercial potential. It will provide a marketable software shell which alleviates the need for knowledge engineers and increase productivity in the workplace. The KBSD will therefore make knowledge-based systems available to a large portion of industry.


    Yao Jianchu; Zhou Ji; Yu Jun


    A concept of an intelligent optimal design approach is proposed, which is organized by a kind of compound knowledge model. The compound knowledge consists of modularized quantitative knowledge, inclusive experience knowledge and case-based sample knowledge. By using this compound knowledge model, the abundant quantity information of mathematical programming and the symbolic knowledge of artificial intelligence can be united together in this model. The intelligent optimal design model based on such a compound knowledge and the automatically generated decomposition principles based on it are also presented. Practically, it is applied to the production planning, process schedule and optimization of production process of a refining & chemical work and a great profit is achieved. Specially, the methods and principles are adaptable not only to continuous process industry, but also to discrete manufacturing one.

  11. System Engineering for the NNSA Knowledge Base

    Young, C.; Ballard, S.; Hipp, J.


    To improve ground-based nuclear explosion monitoring capability, GNEM R&E (Ground-based Nuclear Explosion Monitoring Research & Engineering) researchers at the national laboratories have collected an extensive set of raw data products. These raw data are used to develop higher level products (e.g. 2D and 3D travel time models) to better characterize the Earth at regional scales. The processed products and selected portions of the raw data are stored in an archiving and access system known as the NNSA (National Nuclear Security Administration) Knowledge Base (KB), which is engineered to meet the requirements of operational monitoring authorities. At its core, the KB is a data archive, and the effectiveness of the KB is ultimately determined by the quality of the data content, but access to that content is completely controlled by the information system in which that content is embedded. Developing this system has been the task of Sandia National Laboratories (SNL), and in this paper we discuss some of the significant challenges we have faced and the solutions we have engineered. One of the biggest system challenges with raw data has been integrating database content from the various sources to yield an overall KB product that is comprehensive, thorough and validated, yet minimizes the amount of disk storage required. Researchers at different facilities often use the same data to develop their products, and this redundancy must be removed in the delivered KB, ideally without requiring any additional effort on the part of the researchers. Further, related data content must be grouped together for KB user convenience. Initially SNL used whatever tools were already available for these tasks, and did the other tasks manually. The ever-growing volume of KB data to be merged, as well as a need for more control of merging utilities, led SNL to develop our own java software package, consisting of a low- level database utility library upon which we have built several

  12. Does the Transition to an Active-Learning Environment for the Introductory Course Reduce Students’ Overall Knowledge of the Various Disciplines in Biology?

    Maryanne C. Simurda


    Full Text Available As biology education is being redesigned toward an interdisciplinary focus and as pedagogical trends move toward active-learning strategies and investigative experiences, a restructuring of the course content for the Introductory Biology course is necessary. The introductory course in biology has typically been a survey of all the biosciences. If the total number of topics covered is reduced, is the students’ overall knowledge of biology also reduced? Our introductory course has been substantially modified away from surveying the biological sciences and toward providing a deep understanding of a particular biological topic, as well as focusing on developing students’ analytical and communication skills. Because of this shift to a topic-driven approach for the introductory course, we were interested in assessing our graduating students’ overall knowledge of the various biological disciplines. Using the Major Field Test - Biology (Educational Testing Service (ETS, Princeton, NJ, we compared the test performance of graduating students who had a traditional lecture-based introductory course to those who had a topic-driven active-learning introductory course. Our results suggest that eliminating the traditional survey of biology and, instead, focusing on quantitative and writing skills at the introductory level do not affect our graduating students’ overall breadth of knowledge of the various biosciences.

  13. The Knowledge-Based Economy and the Triple Helix Model

    Leydesdorff, Loet


    1. Introduction - the metaphor of a "knowledge-based economy"; 2. The Triple Helix as a model of the knowledge-based economy; 3. Knowledge as a social coordination mechanism; 4. Neo-evolutionary dynamics in a Triple Helix of coordination mechanism; 5. The operation of the knowledge base; 6. The restructuring of knowledge production in a KBE; 7. The KBE and the systems-of-innovation approach; 8. The KBE and neo-evolutionary theories of innovation; 8.1 The construction of the evolving unit; 8.2 User-producer relations in systems of innovation; 8.3 'Mode-2' and the production of scientific knowledge; 8.4 A Triple Helix model of innovations; 9. Empirical studies and simulations using the TH model; 10. The KBE and the measurement; 10.1 The communication of meaning and information; 10.2 The expectation of social structure; 10.3 Configurations in a knowledge-based economy

  14. Subject-specific pedagogical content knowledge: Implications for alternatively and traditionally trained biology teachers

    Ravgiala, Rebekah Rae

    Theories regarding the development of expertise hold implications for alternative and traditional certification programs and the teachers they train. The literature suggests that when compared to experts in the field of teaching, the behaviors of novices differ in ways that are directly attributed to their pedagogical content knowledge. However, few studies have examined how first and second year biology teachers entering the profession from traditional and alternative training differ in their demonstration of subject-specific pedagogical content knowledge. The research problem in this multicase, naturalistic inquiry investigated how subject-specific pedagogical content knowledge was manifested among first and second year biology teachers in the task of transforming subject matter into forms that are potentially meaningful to students when explicit formal training has been and has not been imparted to them as preservice teachers. Two first year and two second year biology teachers were the subjects of this investigation. Allen and Amber obtained their certification through an alternative summer training institute in consecutive years. Tiffany and Tricia obtained their certification through a traditional, graduate level training program in consecutive years. Both programs were offered at the same northeastern state university. Participants contributed to six data gathering techniques including an initial semi-structured interview, responses to the Conceptions of Teaching Science questionnaire (Hewson & Hewson, 1989), three videotaped biology lessons, evaluation of three corresponding lesson plans, and a final semi-structured interview conducted at the end of the investigation. An informal, end-of-study survey intended to offer participants an opportunity to disclose their thoughts and needs as first year teachers was also employed. Results indicate that while conceptions of teaching science may vary slightly among participants, there is no evidence to suggest that

  15. Background, progress and prospect of traditional knowledge under the Convention on Biological Diversity

    Fuwei Zhao; Jianyong Wu; Dayuan Xue


    Due to its scientific value, economic potential, and social background basis, traditional knowledge (TK) is valued of great importance under the Convention on Biological Diversity (CBD) and by other international fora. The Convention has made enormous efforts for the protection of TK relevant to biodiversity. For instance, an ad hoc working group on Article 8(j) and related provisions was established; programmes of work and action plans on the implementation of Article 8(j) and related provis...

  16. Project-Based Learning and the Limits of Corporate Knowledge.

    Rhodes, Carl; Garrick, John


    Analysis of management discourses, especially project-based learning and knowledge management, indicates that such terms as human capital, working knowledge, and knowledge assets construe managerial workers as cogito-economic subjects. Although workplace learning should develop economically related capabilities, such discourses imply that these…

  17. Knowledge Sharing in an American Multinational Company Based in Malaysia

    Ling, Chen Wai; Sandhu, Manjit S.; Jain, Kamal Kishore


    Purpose: This paper seeks to examine the views of executives working in an American based multinational company (MNC) about knowledge sharing, barriers to knowledge sharing, and strategies to promote knowledge sharing. Design/methodology/approach: This study was carried out in phases. In the first phase, a topology of organizational mechanisms for…

  18. Korea : Transition to a Knowledge-Based Economy

    World Bank


    The report reviews the economic transition in Korea, summarizing the challenge of the knowledge revolution, to the country's development strategy, and the analytical, and policy framework for a knowledge-based economy. It explores the needs to increase overall productivity, and areas of relative inefficiency, namely, inadequate conditions for generation of knowledge, and information; insuf...

  19. Hyperincursion and the Globalization of the Knowledge-Based Economy

    Leydesdorff, Loet


    In biological systems, the capacity of anticipation—that is, entertaining a model of the system within the system—can be considered as naturally given. Human languages enable psychological systems to construct and exchange mental models of themselves and their environments reflexively, that is, provide meaning to the events. At the level of the social system expectations can further be codified. When these codifications are functionally differentiated—like between market mechanisms and scientific research programs—the potential asynchronicity in the update among the subsystems provides room for a second anticipatory mechanism at the level of the transversal information exchange among differently codified meaning-processing subsystems. Interactions between the two different anticipatory mechanisms (the transversal one and the one along the time axis in each subsystem) may lead to co-evolutions and stabilization of expectations along trajectories. The wider horizon of knowledgeable expectations can be expected to meta-stabilize and also globalize a previously stabilized configuration of expectations against the axis of time. While stabilization can be considered as consequences of interaction and aggregation among incursive formulations of the logistic equation, globalization can be modeled using the hyperincursive formulation of this equation. The knowledge-based subdynamic at the global level which thus emerges, enables historical agents to inform the reconstruction of previous states and to co-construct future states of the social system, for example, in a techno-economic co-evolution.

  20. Weather, knowledge base and life-style

    Bohle, Martin


    Why to main-stream curiosity for earth-science topics, thus to appraise these topics as of public interest? Namely, to influence practices how humankind's activities intersect the geosphere. How to main-stream that curiosity for earth-science topics? Namely, by weaving diverse concerns into common threads drawing on a wide range of perspectives: be it beauty or particularity of ordinary or special phenomena, evaluating hazards for or from mundane environments, or connecting the scholarly investigation with concerns of citizens at large; applying for threading traditional or modern media, arts or story-telling. Three examples: First "weather"; weather is a topic of primordial interest for most people: weather impacts on humans lives, be it for settlement, for food, for mobility, for hunting, for fishing, or for battle. It is the single earth-science topic that went "prime-time" since in the early 1950-ties the broadcasting of weather forecasts started and meteorologists present their work to the public, daily. Second "knowledge base"; earth-sciences are a relevant for modern societies' economy and value setting: earth-sciences provide insights into the evolution of live-bearing planets, the functioning of Earth's systems and the impact of humankind's activities on biogeochemical systems on Earth. These insights bear on production of goods, living conditions and individual well-being. Third "life-style"; citizen's urban culture prejudice their experiential connections: earth-sciences related phenomena are witnessed rarely, even most weather phenomena. In the past, traditional rural communities mediated their rich experiences through earth-centric story-telling. In course of the global urbanisation process this culture has given place to society-centric story-telling. Only recently anthropogenic global change triggered discussions on geoengineering, hazard mitigation, demographics, which interwoven with arts, linguistics and cultural histories offer a rich narrative

  1. A Knowledge Representation Model for Video—Based Animation

    劳志强; 潘云鹤


    In this paper,a brief survey on knowledge-based animation techniques is given.Then a VideoStream-based Knowledge Representation Model(VSKRM)for Joint Objects is presented which includes the knowledge representation of :Graphic Object,Action and VideoStream.Next a general description of the UI framework of a system is given based on the VSKRM model.Finally,a conclusion is reached.

  2. Toward a Category Theory Design of Ontological Knowledge Bases

    Glazunov, Nikolaj


    I discuss (ontologies_and_ontological_knowledge_bases / formal_methods_and_theories) duality and its category theory extensions as a step toward a solution to Knowledge-Based Systems Theory. In particular I focus on the example of the design of elements of ontologies and ontological knowledge bases of next three electronic courses: Foundations of Research Activities, Virtual Modeling of Complex Systems and Introduction to String Theory.

  3. Reflections on Communication Culture in the Knowledge-Based Economy

    Manoela Popescu


    Known is that the pillars of the knowledge-based economy are information, connection of information and communication. Complexity of the processes taking place in the knowledge-based economy and structural changes posed by this leads to highlighting required versatility and increased ambiguity in terms of both information and communication. This is because knowledge-based economy is not limiting his horizons, but rather help to build content and communication complexity. Thus, in the digital ...




    This paper is focused on the use of Knowledge Management techniques to develop environments of Web-Based Education to leverage the individual learning process for learners. Evolving use of Knowledge Management plays an important role to enhance problem solving skills. Recently, innovative approaches for integrating Knowledge Management into practical teaching activities have been ignored. The knowledge is defined as combination and organization of data and information in given context, and Kn...

  5. A Knowledge-Based Perspective for Software Process Modeling

    Noureddine Kerzazi; Mathieu Lavallée; Pierre-N. Robillard


    As the acquisition and sharing of knowledge form the backbone of the software development process, it is important to identify knowledge discrepancies between the process elements. Explicit representation of the knowledge components within a software process model can provide a means to expose these discrepancies. This paper presents an extension of the Software and System Process Engineering Metamodel (SPEM), to be used as a new knowledge modeling layer. The approach, which is based on ontol...

  6. Knowledge marketing and development in the new knowledge-based economy

    Ani MATEI; Matei, Lucica


    The purpose of this paper is to analyze and describe the relation between knowledge and development in the new knowledge-based economy and to deduct the socio-economic basics of the public marketing strategies in this context. The particularity of this approach is due to the features of knowledge, seen as production factor, mixed public good or global public good, as well as their developments in the context of relationships between university and industry, the new role of publ...

  7. Distributed Knowledge in Case-Based Reasoning : Knowledge Sharing and Reuse within the Semantic Web

    Fidjeland, Mikael Kirkeby


    The Semantic Web is an emerging framework for data reuse and sharing. By giving data clear semantics it allows for machine processing of this information. The Semantic Web technologies range from simple meta data to domain models using the Web Ontology Languge (OWL). Much of the semantics of OWL stems from the Knowledge Representation field of Description Logics. Case-Based Reasoning (CBR) uses specific knowledge in the form of cases to solve problems. The Creek system is a Knowledge-Intens...

  8. Knowledge Based Oil and Gas Industry

    Sasson, Amir; Blomgren, Atle


    This study presents the Norwegian upstream oil and gas industry (defined as all oil and gas related firms located in Norway, regardless of ownership) and evaluates the industry according to the underlying dimensions of a global knowledge hub - cluster attractiveness, education attractiveness, talent attractiveness, RandD and innovation attractiveness, ownership attractiveness, environmental attractiveness and cluster dynamics.(au)

  9. Knowledge Based Oil and Gas Industry

    Sasson, Amir; Blomgren, Atle


    This study presents the Norwegian upstream oil and gas industry (defined as all oil and gasrelated firms located in Norway, regardless of ownership) and evaluates the industry according to the underlying dimensions of a global knowledge hub - cluster attractiveness, education attractiveness, talent attractiveness, R&D and innovation attractiveness, ownership attractiveness, environmental attractiveness and cluster dynamics.

  10. In defense of types in knowledge-based CAAD

    Galle, Per

    There are two basic approaches to representation of design knowledge in knowledge-based CAAD systems, the type-based approach which has a long tradition, and the more recent typeless approach. Proponents of the latter have offered a number of arguments against the type-based approach which are...

  11. An Evaluation of Applying Knowledge Base to Academic Information Service

    Seok-Hyoung Lee


    Full Text Available Through a series of precise text handling processes, including automatic extraction of information from documents with knowledge from various fields, recognition of entity names, detection of core topics, analysis of the relations between the extracted information and topics, and automatic inference of new knowledge, the most efficient knowledge base of the relevant field is created, and plans to apply these to the information knowledge management and service are the core requirements necessary for intellectualization of information. In this paper, the knowledge base, which is a necessary core resource and comprehensive technology for intellectualization of science and technology information, is described and the usability of academic information services using it is evaluated. The knowledge base proposed in this article is an amalgamation of information expression and knowledge storage, composed of identifying code systems from terms to documents, by integrating terminologies, word intelligent networks, topic networks, classification systems, and authority data.

  12. Semantic Network Based Mechanisms for Knowledge Acquistion

    Dariusz Ceglarek


    Full Text Available This a rticle summarizes research work started with the SeiPro2S (Semantically Enhanced Intellectual Property Protection System system designed to protect resources fro m the unauthorized use of intel lectual property. The system implements semantic network as a s tructure of knowledge repre sentation and a new idea of semantic compression. As the author proved that semantic compression is viable concept for English, he decided to focus on potential applications. An alg orithm is presented that employ ing semantic net work WiSENet for knowledge acquisition with flexible rules that yield high precision results. Developed algorithm is implemented as a Finite State Automaton with advanced methods for triggering desired actions. Detailed discussion is given with description of devised algorithm, u s age examples and results of experi ments.

  13. Knowledge-based methods for control systems

    This thesis consists of three projects which combine artificial intelligence and control. The first part describes an expert system interface for system identification, using the interactive identification program Idpac. The interface works as an intelligent help system, using the command spy strategy. It contains a multitude of help system ideas. The concept of scripts is introduced as a data structure used to describe the procedural part of the knowledge in the interface. Production rules are used to represent diagnostic knowledge. A small knowledge database of scripts and rules has been developed and an example run is shown. The second part describes an expert system for frequency response analysis. This is one of the oldest and most widely used methods to determine the dynamics of a stable linear system. Though quite simple, it requires knowledge and experience of the user, in order to produce reliable results. The expert system is designed to help the user in performing the analysis. It checks whether the system is linear, finds the frequency and amplitude ranges, verifies the results, and, if errors should occur, tries to give explanation and remedies for them. The third part describes three diagnostic methods for use with industrial processes. They are measurement validation, i.e., consistency checking of sensor and measurement values using any redundancy of instrumentation; alarm analysis, i.e. analysis of multiple alarm situations to find which alarms are directly connected to primary faults and which alarms are consequential effects of the primary ones; and fault diagnosis, i.e., a search for the causes of and remedies for faults. The three methods use multilevel flow models, (MFM), to describe the target process. They have been implemented in the programming tool G2, and successfully tested on two small processes. (164 refs.) (au)

  14. Introducing Dynamic Behavior in Amalgamated Knowledge Bases

    Bertino, Elisa; Catania, Barbara; Perlasca, Paolo


    The problem of integrating knowledge from multiple and heterogeneous sources is a fundamental issue in current information systems. In order to cope with this problem, the concept of mediator has been introduced as a software component providing intermediate services, linking data resources and application programs, and making transparent the heterogeneity of the underlying systems. In designing a mediator architecture, we believe that an important aspect is the definition of a formal framewo...

  15. Knowledge Based Incubators In Theory And Practice

    Esad Ahmetagic; Peter Harmath


    Incubators of knowledge, entrepreneurial incubators or business incubators are different names and approaches to the same process, improving the entrepreneurial spirit in the company or certain social environment. Entrepreneurial concept involves the creation of ideas that can commercialize the product or service to be profitable in the market. The article is introducing a special approach by linking university experts and their problem solving abilities with company in the need for their hel...

  16. Semantic Knowledge Bases from Web Sources

    Fabian Suchanek; Martin Theobald; Gerhard Weikum; Hady Lauw; Ralf Schenkel


    The Web bears the potential of being the world's greatest encyclopedic source, but we are far from fully ex- ploiting this potential. Valuable scientific and cultural content is interspersed with a huge amount of noisy, low- quality, unstructured text and media. The proliferation of knowledge-sharing communities like Wikipedia and the advances in automated information extraction from Web pages give rise to an unprecedented opportunity: Can we systematically harvest facts from the Web and comp...

  17. Study of Mechanical Product Rapid Design Based on Knowledge Engineering

    TAI Li-gang; ZHONG Ting-xiu


    This paper proposes a mechanical product intelligent rapid design approach based on integrated technologies. Adopting knowledge based engineering to reuse and manage product design knowledge, and combining feature modeling and parametric design based on existing CAD/CAE/CAM system and technology of product family modeling and engineering database, the system establishes a product family knowledge base, which mainly including product family case base and rule base. The system also utilizes WEB technology to let customers to individually customize products remotely through internet. And an applicable example is given in the end.

  18. Knowledge acquisition method for case-knowledge-based product family design


    Knowledge acquisition has always been the bottleneck of artificial intelligence. It is the critical point in product family design. Here a knowledge acquisition method was introduced based on scenario model and repository grid and attribute ordering table technology. This method acquired knowledge through providing product design cases to expert, and recording the means and knowledge used by the expert to describe and resolve problems. It used object to express design entity, used scenario to describe the design process, used Event-Condition-Action (ECA) rule to drive design process, and with the help of repository grid and attribute ordering table technology to acquire design knowledge. It's a good way to capture explicit and implicit knowledge. And its validity is proved with respective examples.


    Alina HAGIU; Marinela TANASCOVICI


    Knowledge-based organizations (KBO) are usually considered to be those whose product or service is knowledge-intensive. The characteristics of a KBO, however, go beyond product to include process, purpose and perspective. Process refers to an organization’s knowledge based activities and processes. Purpose refers to its mission and strategy. Perspective refers to the worldview and culture that influence and constrain an organization’s decisions and actions. In order for organizations to remai...

  20. KSBT: A Knowledge-based Systems Building Tool

    Bruno, Silvia; Dip. di Ingegneria Strutturale "La Sapienza"; Gavarini, Carlo; Dip. di Ingegneria Strutturale "La Sapienza"; Padula, Antonio; Istituto Nazionale di Geofisica e Vulcanologia, Sezione CNT, Roma, Italia; Vittori, Federico; Dip. di Ingegneria Strutturale "La Sapienza"


    The increasing interest in AI as a powerful aid in solving civil engineering problems has suggested the realization of a domain-independent tool for knowledge-based systems construction. The paper provides the description of a fuzzy inference engine, which has appropriately been developed in order to both build knowledge bases and to perform evaluations. Knowledge acquisition issues and approximate reasoning techniques are also illustrated and discussed.




    The present paper examines the importance of education as a cornerstone to the knowledge-based society of future Europe and to its implementation in Romania. The aim herein is to outline that at present, in order for the society to meet the current needs and to lie the foundations of highly performing, receptive economy in terms of the specific requirements of ”knowledge-based society”, it must promote and implement new, modern management techniques, knowledge, and tools to support such activ...

  2. Competitiveness of knowledge-based economies. Suggestion for measuring

    Malgorzata Madrak-Grochowska


    The present paper focuses on a presentation of four pillars of knowledge, occurring as the sources of competitive advantage for knowledge-based economies, and on the construction of taxonomic measure for assessing competitiveness’ degree of 29 this type economies in 2000-2010. To build this taxonomic measure, author used 21 diagnostic variables representing four areas of knowledge-based economies’ competitiveness, i.e. the system of economic incentives and institutional regime, well educated ...

  3. Examining the pedagogical content knowledge and practice of experienced secondary biology teachers for teaching diffusion and osmosis

    Lankford, Deanna

    Teachers are the most important factor in student learning (National Research Council, 1996); yet little is known about the specialized knowledge held by experienced teachers. The purpose of this study was twofold: first, to make explicit the pedagogical content knowledge (PCK) for teaching diffusion and osmosis held by experienced biology teachers and, second, to reveal how topic-specific PCK informs teacher practice. The Magnusson et al. (1999) PCK model served as the theoretical framework for the study. The overarching research question was: When teaching lessons on osmosis and diffusion, how do experienced biology teachers draw upon their topic-specific pedagogical content knowledge? Data sources included observations of two consecutive lessons, three semi-structured interviews, lesson plans, and student handouts. Data analysis indicated five of the six teachers held a constructivist orientation to science teaching and engaged students in explorations of diffusion and osmosis prior to introducing the concepts to students. Explanations for diffusion and osmosis were based upon students' observations and experiences during explorations. All six teachers used representations at the molecular, cellular, and plant organ levels to serve as foci for explorations of diffusion and osmosis. Three potential learning difficulties identified by the teachers included: (a) understanding vocabulary terms, (b) predicting the direction of osmosis, and (c) identifying random molecular motion as the driving force for diffusion and osmosis. Participants used student predictions as formative assessments to reveal misconceptions before instruction and evaluate conceptual understanding during instruction. This study includes implications for teacher preparation, research, and policy.

  4. Language Based Techniques for Systems Biology

    Pilegaard, Henrik

    calculi have similarly been used for the study of bio-chemical reactive systems. In this dissertation it is argued that techniques rooted in the theory and practice of programming languages, language based techniques if you will, constitute a strong basis for the investigation of models of biological......Process calculus is the common denominator for a class of compact, idealised, domain-specific formalisms normally associated with the study of reactive concurrent systems within Computer Science. With the rise of the interactioncentred science of Systems Biology a number of bio-inspired process...... systems as formalised in a process calculus. In particular it is argued that Static Program Analysis provides a useful approach to the study of qualitative properties of such models. In support of this claim a number of static program analyses are developed for Regev’s BioAmbients – a bio-inspired variant...

  5. Model-based reasoning and large-knowledge bases

    In such engineering fields as nuclear power plant engineering, technical information expressed in the form of schematics is frequently used. A new paradigm for model-based reasoning (MBR) and an AI tool called PLEXSYS (plant expert system) using this paradigm has been developed. PLEXSYS and the underlying paradigm are specifically designed to handle schematic drawings, by expressing drawings as models and supporting various sophisticated searches on these models. Two application systems have been constructed with PLEXSYS: one generates PLEXSYS models from existing CAD data files, and the other provides functions for nuclear power plant design support. Since the models can be generated from existing data resources, the design support system automatically has full access to a large-scale model or knowledge base representing actual nuclear power plants. (author)


    LIANG Jun; JIANG Zuhua; ZHEN Lu; SU Hai; WANG Kuoming


    To support and serve engineering design, creative design based on knowledge management is proposed. The key knowledge factors of creative design are analyzed and discussed, and knowledge extraction tools are utilized to distill the important knowledge to serve for knowledge resource of creative design. The implementation of creative design mode is described and executed, which can promote the intelligent asset of the enterprise and shorten the period of creative design. With this study, design afflatus and conceptual design can be achieved expediently and effectively.

  7. Knowledge-based analysis of phenotypes

    Hoendorf, Robert


    Phenotypes are the observable characteristics of an organism, and they are widely recorded in biology and medicine. To facilitate data integration, ontologies that formally describe phenotypes are being developed in several domains. I will describe a formal framework to describe phenotypes. A formalized theory of phenotypes is not only useful for domain analysis, but can also be applied to assist in the diagnosis of rare genetic diseases, and I will show how our results on the ontology of phenotypes is now applied in biomedical research.

  8. Applying Knowledge-Based Techniques to Software Development.

    Harandi, Mehdi T.


    Reviews overall structure and design principles of a knowledge-based programming support tool, the Knowledge-Based Programming Assistant, which is being developed at University of Illinois Urbana-Champaign. The system's major units (program design program coding, and intelligent debugging) and additional functions are described. (MBR)

  9. Transition to knowledge-based economy in Saudi Arabia

    Nour, S.


    This paper discusses the progress in transition to knowledge-based economy in Saudi Arabia. As for the methodology, this paper uses updated secondary data obtained from different sources. It uses both descriptive and comparative approaches and uses the OECD definition of knowledge-based economy and

  10. The Sixth Annual Knowledge-Based Software Engineering Conference

    Selfridge, Peter G.


    The Sixth Annual Knowledge-Based Software Engineering Conference (KBSE-91) was held at the Sheraton University Inn and Conference Center in Syracuse, New York, from Sunday afternoon, 22 September, through midday Wednesday, 25 September. The KBSE field is concerned with applying knowledge-based AI techniques to the problems of creating, understanding, and maintaining very large software systems.