A unified framework for benchmark dose estimation applied to mixed models and model averaging

DEFF Research Database (Denmark)

Ritz, Christian; Gerhard, Daniel; Hothorn, Ludwig A.

2013-01-01

for hierarchical data structures, reflecting increasingly common types of assay data. We illustrate the usefulness of the methodology by means of a cytotoxicology example where the sensitivity of two types of assays are evaluated and compared. By means of a simulation study, we show that the proposed framework......This article develops a framework for benchmark dose estimation that allows intrinsically nonlinear dose-response models to be used for continuous data in much the same way as is already possible for quantal data. This means that the same dose-response model equations may be applied to both...

Benchmark for the qualification of gamma shielding calculation methods for light-water type reactor spent fuels

International Nuclear Information System (INIS)

Blum, P.; Cagnon, R.; Nimal, J.C.

1982-01-01

This report gives the results of a campaign of gamma dose rates measurement in the vicinity of a transport package loaded with 12 PWR spent fuel assemblies, so that the characteristics of the package and the fuel. It describes the measuring methods, and gives the accuracy of the data which will be usefull, as benchmarks, to the control of the calculation methods used to verify the gamma shielding of the packages. It shows how to calculate gamma dose rates from the data given on the package and the fuel, and gives the results of a calculation with the Mecure IV code and compares them to the measurements

Benchmarking with high-order nodal diffusion methods

International Nuclear Information System (INIS)

Tomasevic, D.; Larsen, E.W.

1993-01-01

Significant progress in the solution of multidimensional neutron diffusion problems was made in the late 1970s with the introduction of nodal methods. Modern nodal reactor analysis codes provide significant improvements in both accuracy and computing speed over earlier codes based on fine-mesh finite difference methods. In the past, the performance of advanced nodal methods was determined by comparisons with fine-mesh finite difference codes. More recently, the excellent spatial convergence of nodal methods has permitted their use in establishing reference solutions for some important bench-mark problems. The recent development of the self-consistent high-order nodal diffusion method and its subsequent variational formulation has permitted the calculation of reference solutions with one node per assembly mesh size. In this paper, we compare results for four selected benchmark problems to those obtained by high-order response matrix methods and by two well-known state-of-the-art nodal methods (the open-quotes analyticalclose quotes and open-quotes nodal expansionclose quotes methods)

Benchmarking of methods for genomic taxonomy

DEFF Research Database (Denmark)

Larsen, Mette Voldby; Cosentino, Salvatore; Lukjancenko, Oksana

2014-01-01

. Nevertheless, the method has been found to have a number of shortcomings. In the current study, we trained and benchmarked five methods for whole-genome sequence-based prokaryotic species identification on a common data set of complete genomes: (i) SpeciesFinder, which is based on the complete 16S rRNA gene...

Point kernels and superposition methods for scatter dose calculations in brachytherapy

International Nuclear Information System (INIS)

Carlsson, A.K.

2000-01-01

Point kernels have been generated and applied for calculation of scatter dose distributions around monoenergetic point sources for photon energies ranging from 28 to 662 keV. Three different approaches for dose calculations have been compared: a single-kernel superposition method, a single-kernel superposition method where the point kernels are approximated as isotropic and a novel 'successive-scattering' superposition method for improved modelling of the dose from multiply scattered photons. An extended version of the EGS4 Monte Carlo code was used for generating the kernels and for benchmarking the absorbed dose distributions calculated with the superposition methods. It is shown that dose calculation by superposition at and below 100 keV can be simplified by using isotropic point kernels. Compared to the assumption of full in-scattering made by algorithms currently in clinical use, the single-kernel superposition method improves dose calculations in a half-phantom consisting of air and water. Further improvements are obtained using the successive-scattering superposition method, which reduces the overestimates of dose close to the phantom surface usually associated with kernel superposition methods at brachytherapy photon energies. It is also shown that scatter dose point kernels can be parametrized to biexponential functions, making them suitable for use with an effective implementation of the collapsed cone superposition algorithm. (author)

Benchmarking routine psychological services: a discussion of challenges and methods.

Science.gov (United States)

Delgadillo, Jaime; McMillan, Dean; Leach, Chris; Lucock, Mike; Gilbody, Simon; Wood, Nick

2014-01-01

Policy developments in recent years have led to important changes in the level of access to evidence-based psychological treatments. Several methods have been used to investigate the effectiveness of these treatments in routine care, with different approaches to outcome definition and data analysis. To present a review of challenges and methods for the evaluation of evidence-based treatments delivered in routine mental healthcare. This is followed by a case example of a benchmarking method applied in primary care. High, average and poor performance benchmarks were calculated through a meta-analysis of published data from services working under the Improving Access to Psychological Therapies (IAPT) Programme in England. Pre-post treatment effect sizes (ES) and confidence intervals were estimated to illustrate a benchmarking method enabling services to evaluate routine clinical outcomes. High, average and poor performance ES for routine IAPT services were estimated to be 0.91, 0.73 and 0.46 for depression (using PHQ-9) and 1.02, 0.78 and 0.52 for anxiety (using GAD-7). Data from one specific IAPT service exemplify how to evaluate and contextualize routine clinical performance against these benchmarks. The main contribution of this report is to summarize key recommendations for the selection of an adequate set of psychometric measures, the operational definition of outcomes, and the statistical evaluation of clinical performance. A benchmarking method is also presented, which may enable a robust evaluation of clinical performance against national benchmarks. Some limitations concerned significant heterogeneity among data sources, and wide variations in ES and data completeness.

Aircraft Engine Gas Path Diagnostic Methods: Public Benchmarking Results

Science.gov (United States)

Simon, Donald L.; Borguet, Sebastien; Leonard, Olivier; Zhang, Xiaodong (Frank)

2013-01-01

Recent technology reviews have identified the need for objective assessments of aircraft engine health management (EHM) technologies. To help address this issue, a gas path diagnostic benchmark problem has been created and made publicly available. This software tool, referred to as the Propulsion Diagnostic Method Evaluation Strategy (ProDiMES), has been constructed based on feedback provided by the aircraft EHM community. It provides a standard benchmark problem enabling users to develop, evaluate and compare diagnostic methods. This paper will present an overview of ProDiMES along with a description of four gas path diagnostic methods developed and applied to the problem. These methods, which include analytical and empirical diagnostic techniques, will be described and associated blind-test-case metric results will be presented and compared. Lessons learned along with recommendations for improving the public benchmarking processes will also be presented and discussed.

A biosegmentation benchmark for evaluation of bioimage analysis methods

Directory of Open Access Journals (Sweden)

Kvilekval Kristian

2009-11-01

Full Text Available Abstract Background We present a biosegmentation benchmark that includes infrastructure, datasets with associated ground truth, and validation methods for biological image analysis. The primary motivation for creating this resource comes from the fact that it is very difficult, if not impossible, for an end-user to choose from a wide range of segmentation methods available in the literature for a particular bioimaging problem. No single algorithm is likely to be equally effective on diverse set of images and each method has its own strengths and limitations. We hope that our benchmark resource would be of considerable help to both the bioimaging researchers looking for novel image processing methods and image processing researchers exploring application of their methods to biology. Results Our benchmark consists of different classes of images and ground truth data, ranging in scale from subcellular, cellular to tissue level, each of which pose their own set of challenges to image analysis. The associated ground truth data can be used to evaluate the effectiveness of different methods, to improve methods and to compare results. Standard evaluation methods and some analysis tools are integrated into a database framework that is available online at http://bioimage.ucsb.edu/biosegmentation/. Conclusion This online benchmark will facilitate integration and comparison of image analysis methods for bioimages. While the primary focus is on biological images, we believe that the dataset and infrastructure will be of interest to researchers and developers working with biological image analysis, image segmentation and object tracking in general.

Current modeling practice may lead to falsely high benchmark dose estimates.

Science.gov (United States)

Ringblom, Joakim; Johanson, Gunnar; Öberg, Mattias

2014-07-01

Benchmark dose (BMD) modeling is increasingly used as the preferred approach to define the point-of-departure for health risk assessment of chemicals. As data are inherently variable, there is always a risk to select a model that defines a lower confidence bound of the BMD (BMDL) that, contrary to expected, exceeds the true BMD. The aim of this study was to investigate how often and under what circumstances such anomalies occur under current modeling practice. Continuous data were generated from a realistic dose-effect curve by Monte Carlo simulations using four dose groups and a set of five different dose placement scenarios, group sizes between 5 and 50 animals and coefficients of variations of 5-15%. The BMD calculations were conducted using nested exponential models, as most BMD software use nested approaches. "Non-protective" BMDLs (higher than true BMD) were frequently observed, in some scenarios reaching 80%. The phenomenon was mainly related to the selection of the non-sigmoidal exponential model (Effect=a·e(b)(·dose)). In conclusion, non-sigmoid models should be used with caution as it may underestimate the risk, illustrating that awareness of the model selection process and sound identification of the point-of-departure is vital for health risk assessment. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Shutdown Dose Rate Analysis Using the Multi-Step CADIS Method

International Nuclear Information System (INIS)

Ibrahim, Ahmad M.; Peplow, Douglas E.; Peterson, Joshua L.; Grove, Robert E.

2015-01-01

The Multi-Step Consistent Adjoint Driven Importance Sampling (MS-CADIS) hybrid Monte Carlo (MC)/deterministic radiation transport method was proposed to speed up the shutdown dose rate (SDDR) neutron MC calculation using an importance function that represents the neutron importance to the final SDDR. This work applied the MS-CADIS method to the ITER SDDR benchmark problem. The MS-CADIS method was also used to calculate the SDDR uncertainty resulting from uncertainties in the MC neutron calculation and to determine the degree of undersampling in SDDR calculations because of the limited ability of the MC method to tally detailed spatial and energy distributions. The analysis that used the ITER benchmark problem compared the efficiency of the MS-CADIS method to the traditional approach of using global MC variance reduction techniques for speeding up SDDR neutron MC calculation. Compared to the standard Forward-Weighted-CADIS (FW-CADIS) method, the MS-CADIS method increased the efficiency of the SDDR neutron MC calculation by 69%. The MS-CADIS method also increased the fraction of nonzero scoring mesh tally elements in the space-energy regions of high importance to the final SDDR

Optimized dose distribution of a high dose rate vaginal cylinder

International Nuclear Information System (INIS)

Li Zuofeng; Liu, Chihray; Palta, Jatinder R.

1998-01-01

Purpose: To present a comparison of optimized dose distributions for a set of high-dose-rate (HDR) vaginal cylinders calculated by a commercial treatment-planning system with benchmark calculations using Monte-Carlo-calculated dosimetry data. Methods and Materials: Optimized dose distributions using both an isotropic and an anisotropic dose calculation model were obtained for a set of HDR vaginal cylinders. Mathematical optimization techniques available in the computer treatment-planning system were used to calculate dwell times and positions. These dose distributions were compared with benchmark calculations with TG43 formalism and using Monte-Carlo-calculated data. The same dwell times and positions were used for a quantitative comparison of dose calculated with three dose models. Results: The isotropic dose calculation model can result in discrepancies as high as 50%. The anisotropic dose calculation model compared better with benchmark calculations. The differences were more significant at the apex of the vaginal cylinder, which is typically used as the prescription point. Conclusion: Dose calculation models available in a computer treatment-planning system must be evaluated carefully to ensure their correct application. It should also be noted that when optimized dose distribution at a distance from the cylinder surface is calculated using an accurate dose calculation model, the vaginal mucosa dose becomes significantly higher, and therefore should be carefully monitored

A large-scale benchmark of gene prioritization methods.

Science.gov (United States)

Guala, Dimitri; Sonnhammer, Erik L L

2017-04-21

In order to maximize the use of results from high-throughput experimental studies, e.g. GWAS, for identification and diagnostics of new disease-associated genes, it is important to have properly analyzed and benchmarked gene prioritization tools. While prospective benchmarks are underpowered to provide statistically significant results in their attempt to differentiate the performance of gene prioritization tools, a strategy for retrospective benchmarking has been missing, and new tools usually only provide internal validations. The Gene Ontology(GO) contains genes clustered around annotation terms. This intrinsic property of GO can be utilized in construction of robust benchmarks, objective to the problem domain. We demonstrate how this can be achieved for network-based gene prioritization tools, utilizing the FunCoup network. We use cross-validation and a set of appropriate performance measures to compare state-of-the-art gene prioritization algorithms: three based on network diffusion, NetRank and two implementations of Random Walk with Restart, and MaxLink that utilizes network neighborhood. Our benchmark suite provides a systematic and objective way to compare the multitude of available and future gene prioritization tools, enabling researchers to select the best gene prioritization tool for the task at hand, and helping to guide the development of more accurate methods.

Benchmarking HRA methods against different NPP simulator data

International Nuclear Information System (INIS)

Petkov, Gueorgui; Filipov, Kalin; Velev, Vladimir; Grigorov, Alexander; Popov, Dimiter; Lazarov, Lazar; Stoichev, Kosta

2008-01-01

The paper presents both international and Bulgarian experience in assessing HRA methods, underlying models approaches for their validation and verification by benchmarking HRA methods against different NPP simulator data. The organization, status, methodology and outlooks of the studies are described

NRC-BNL Benchmark Program on Evaluation of Methods for Seismic Analysis of Coupled Systems

International Nuclear Information System (INIS)

Chokshi, N.; DeGrassi, G.; Xu, J.

1999-01-01

A NRC-BNL benchmark program for evaluation of state-of-the-art analysis methods and computer programs for seismic analysis of coupled structures with non-classical damping is described. The program includes a series of benchmarking problems designed to investigate various aspects of complexities, applications and limitations associated with methods for analysis of non-classically damped structures. Discussions are provided on the benchmarking process, benchmark structural models, and the evaluation approach, as well as benchmarking ground rules. It is expected that the findings and insights, as well as recommendations from this program will be useful in developing new acceptance criteria and providing guidance for future regulatory activities involving licensing applications of these alternate methods to coupled systems

An Economical Approach to Estimate a Benchmark Capital Stock. An Optimal Consistency Method

OpenAIRE

Jose Miguel Albala-Bertrand

2003-01-01

There are alternative methods of estimating capital stock for a benchmark year. However, these methods are costly and time-consuming, requiring the gathering of much basic information as well as the use of some convenient assumptions and guesses. In addition, a way is needed of checking whether the estimated benchmark is at the correct level. This paper proposes an optimal consistency method (OCM), which enables a capital stock to be estimated for a benchmark year, and which can also be used ...

Benchmark experiment to verify radiation transport calculations for dosimetry in radiation therapy; Benchmark-Experiment zur Verifikation von Strahlungstransportrechnungen fuer die Dosimetrie in der Strahlentherapie

Energy Technology Data Exchange (ETDEWEB)

Renner, Franziska [Physikalisch-Technische Bundesanstalt (PTB), Braunschweig (Germany)

2016-11-01

Monte Carlo simulations are regarded as the most accurate method of solving complex problems in the field of dosimetry and radiation transport. In (external) radiation therapy they are increasingly used for the calculation of dose distributions during treatment planning. In comparison to other algorithms for the calculation of dose distributions, Monte Carlo methods have the capability of improving the accuracy of dose calculations - especially under complex circumstances (e.g. consideration of inhomogeneities). However, there is a lack of knowledge of how accurate the results of Monte Carlo calculations are on an absolute basis. A practical verification of the calculations can be performed by direct comparison with the results of a benchmark experiment. This work presents such a benchmark experiment and compares its results (with detailed consideration of measurement uncertainty) with the results of Monte Carlo calculations using the well-established Monte Carlo code EGSnrc. The experiment was designed to have parallels to external beam radiation therapy with respect to the type and energy of the radiation, the materials used and the kind of dose measurement. Because the properties of the beam have to be well known in order to compare the results of the experiment and the simulation on an absolute basis, the benchmark experiment was performed using the research electron accelerator of the Physikalisch-Technische Bundesanstalt (PTB), whose beam was accurately characterized in advance. The benchmark experiment and the corresponding Monte Carlo simulations were carried out for two different types of ionization chambers and the results were compared. Considering the uncertainty, which is about 0.7 % for the experimental values and about 1.0 % for the Monte Carlo simulation, the results of the simulation and the experiment coincide.

Benchmarking: a method for continuous quality improvement in health.

Science.gov (United States)

Ettorchi-Tardy, Amina; Levif, Marie; Michel, Philippe

2012-05-01

Benchmarking, a management approach for implementing best practices at best cost, is a recent concept in the healthcare system. The objectives of this paper are to better understand the concept and its evolution in the healthcare sector, to propose an operational definition, and to describe some French and international experiences of benchmarking in the healthcare sector. To this end, we reviewed the literature on this approach's emergence in the industrial sector, its evolution, its fields of application and examples of how it has been used in the healthcare sector. Benchmarking is often thought to consist simply of comparing indicators and is not perceived in its entirety, that is, as a tool based on voluntary and active collaboration among several organizations to create a spirit of competition and to apply best practices. The key feature of benchmarking is its integration within a comprehensive and participatory policy of continuous quality improvement (CQI). Conditions for successful benchmarking focus essentially on careful preparation of the process, monitoring of the relevant indicators, staff involvement and inter-organizational visits. Compared to methods previously implemented in France (CQI and collaborative projects), benchmarking has specific features that set it apart as a healthcare innovation. This is especially true for healthcare or medical-social organizations, as the principle of inter-organizational visiting is not part of their culture. Thus, this approach will need to be assessed for feasibility and acceptability before it is more widely promoted.

The current state of knowledge on the use of the benchmark dose concept in risk assessment.

Science.gov (United States)

Sand, Salomon; Victorin, Katarina; Filipsson, Agneta Falk

2008-05-01

This review deals with the current state of knowledge on the use of the benchmark dose (BMD) concept in health risk assessment of chemicals. The BMD method is an alternative to the traditional no-observed-adverse-effect level (NOAEL) and has been presented as a methodological improvement in the field of risk assessment. The BMD method has mostly been employed in the USA but is presently given higher attention also in Europe. The review presents a number of arguments in favor of the BMD, relative to the NOAEL. In addition, it gives a detailed overview of the several procedures that have been suggested and applied for BMD analysis, for quantal as well as continuous data. For quantal data the BMD is generally defined as corresponding to an additional or extra risk of 5% or 10%. For continuous endpoints it is suggested that the BMD is defined as corresponding to a percentage change in response relative to background or relative to the dynamic range of response. Under such definitions, a 5% or 10% change can be considered as default. Besides how to define the BMD and its lower bound, the BMDL, the question of how to select the dose-response model to be used in the BMD and BMDL determination is highlighted. Issues of study design and comparison of dose-response curves and BMDs are also covered. Copyright (c) 2007 John Wiley & Sons, Ltd.

Benchmarking of MCNP for calculating dose rates at an interim storage facility for nuclear waste.

Science.gov (United States)

Heuel-Fabianek, Burkhard; Hille, Ralf

2005-01-01

During the operation of research facilities at Research Centre Jülich, Germany, nuclear waste is stored in drums and other vessels in an interim storage building on-site, which has a concrete shielding at the side walls. Owing to the lack of a well-defined source, measured gamma spectra were unfolded to determine the photon flux on the surface of the containers. The dose rate simulation, including the effects of skyshine, using the Monte Carlo transport code MCNP is compared with the measured dosimetric data at some locations in the vicinity of the interim storage building. The MCNP data for direct radiation confirm the data calculated using a point-kernel method. However, a comparison of the modelled dose rates for direct radiation and skyshine with the measured data demonstrate the need for a more precise definition of the source. Both the measured and the modelled dose rates verified the fact that the legal limits (<1 mSv a(-1)) are met in the area outside the perimeter fence of the storage building to which members of the public have access. Using container surface data (gamma spectra) to define the source may be a useful tool for practical calculations and additionally for benchmarking of computer codes if the discussed critical aspects with respect to the source can be addressed adequately.

Benchmarking Data Sets for the Evaluation of Virtual Ligand Screening Methods: Review and Perspectives.

Science.gov (United States)

Lagarde, Nathalie; Zagury, Jean-François; Montes, Matthieu

2015-07-27

Virtual screening methods are commonly used nowadays in drug discovery processes. However, to ensure their reliability, they have to be carefully evaluated. The evaluation of these methods is often realized in a retrospective way, notably by studying the enrichment of benchmarking data sets. To this purpose, numerous benchmarking data sets were developed over the years, and the resulting improvements led to the availability of high quality benchmarking data sets. However, some points still have to be considered in the selection of the active compounds, decoys, and protein structures to obtain optimal benchmarking data sets.

Using the fuzzy linear regression method to benchmark the energy efficiency of commercial buildings

International Nuclear Information System (INIS)

Chung, William

2012-01-01

Highlights: ► Fuzzy linear regression method is used for developing benchmarking systems. ► The systems can be used to benchmark energy efficiency of commercial buildings. ► The resulting benchmarking model can be used by public users. ► The resulting benchmarking model can capture the fuzzy nature of input–output data. -- Abstract: Benchmarking systems from a sample of reference buildings need to be developed to conduct benchmarking processes for the energy efficiency of commercial buildings. However, not all benchmarking systems can be adopted by public users (i.e., other non-reference building owners) because of the different methods in developing such systems. An approach for benchmarking the energy efficiency of commercial buildings using statistical regression analysis to normalize other factors, such as management performance, was developed in a previous work. However, the field data given by experts can be regarded as a distribution of possibility. Thus, the previous work may not be adequate to handle such fuzzy input–output data. Consequently, a number of fuzzy structures cannot be fully captured by statistical regression analysis. This present paper proposes the use of fuzzy linear regression analysis to develop a benchmarking process, the resulting model of which can be used by public users. An illustrative example is given as well.

Methods of assessing total doses integrated across pathways

International Nuclear Information System (INIS)

Grzechnik, M.; Camplin, W.; Clyne, F.; Allott, R.; Webbe-Wood, D.

2006-01-01

future years. C) Construct Individuals with high rates of consumption or occupancy across all pathways are used to derive rates for each pathway. These are applied in future years. D) Top-Two High and average consumption and occupancy rates for each pathway are derived. Doses can be calculated for all combinations where two pathways are considered at high rates and the remainder as average E) Profiling A profile is derived by calculating consumption and occupancy rates for each pathway for individuals who exhibit high rates for a single pathway. Other profiles may be built by repeating for other pathways. Total dose is the highest dose for any profile, and that profile becomes known as the critical group. Method A was used as a benchmark, with methods B -E compared according to the previously specified criteria. Overall the profiling method of total dose calculation was adopted due to its favourable overall comparison with the individual method and the homogeneity of the critical group selected. (authors)

svclassify: a method to establish benchmark structural variant calls.

Science.gov (United States)

Parikh, Hemang; Mohiyuddin, Marghoob; Lam, Hugo Y K; Iyer, Hariharan; Chen, Desu; Pratt, Mark; Bartha, Gabor; Spies, Noah; Losert, Wolfgang; Zook, Justin M; Salit, Marc

2016-01-16

The human genome contains variants ranging in size from small single nucleotide polymorphisms (SNPs) to large structural variants (SVs). High-quality benchmark small variant calls for the pilot National Institute of Standards and Technology (NIST) Reference Material (NA12878) have been developed by the Genome in a Bottle Consortium, but no similar high-quality benchmark SV calls exist for this genome. Since SV callers output highly discordant results, we developed methods to combine multiple forms of evidence from multiple sequencing technologies to classify candidate SVs into likely true or false positives. Our method (svclassify) calculates annotations from one or more aligned bam files from many high-throughput sequencing technologies, and then builds a one-class model using these annotations to classify candidate SVs as likely true or false positives. We first used pedigree analysis to develop a set of high-confidence breakpoint-resolved large deletions. We then used svclassify to cluster and classify these deletions as well as a set of high-confidence deletions from the 1000 Genomes Project and a set of breakpoint-resolved complex insertions from Spiral Genetics. We find that likely SVs cluster separately from likely non-SVs based on our annotations, and that the SVs cluster into different types of deletions. We then developed a supervised one-class classification method that uses a training set of random non-SV regions to determine whether candidate SVs have abnormal annotations different from most of the genome. To test this classification method, we use our pedigree-based breakpoint-resolved SVs, SVs validated by the 1000 Genomes Project, and assembly-based breakpoint-resolved insertions, along with semi-automated visualization using svviz. We find that candidate SVs with high scores from multiple technologies have high concordance with PCR validation and an orthogonal consensus method MetaSV (99.7 % concordant), and candidate SVs with low scores are

The Global Benchmarking as a Method of Countering the Intellectual Migration in Ukraine

Directory of Open Access Journals (Sweden)

Striy Lуbov A.

2017-05-01

Full Text Available The publication is aimed at studying the global benchmarking as a method of countering the intellectual migration in Ukraine. The article explores the intellectual process of migration in Ukraine; the current status of the country in the light of crisis and all the problems that arose has been analyzed; statistical data on the migration process are provided, the method of countering it has been determined; types of benchmarking have been considered; the benchmarking method as a way of achieving objective has been analyzed; the benefits to be derived from this method have been determined, as well as «bottlenecks» in the State process of regulating migratory flows, not only to call attention to, but also take corrective actions.

Benchmarking Methods and Data Sets for Ligand Enrichment Assessment in Virtual Screening

Science.gov (United States)

Xia, Jie; Tilahun, Ermias Lemma; Reid, Terry-Elinor; Zhang, Liangren; Wang, Xiang Simon

2014-01-01

Retrospective small-scale virtual screening (VS) based on benchmarking data sets has been widely used to estimate ligand enrichments of VS approaches in the prospective (i.e. real-world) efforts. However, the intrinsic differences of benchmarking sets to the real screening chemical libraries can cause biased assessment. Herein, we summarize the history of benchmarking methods as well as data sets and highlight three main types of biases found in benchmarking sets, i.e. “analogue bias”, “artificial enrichment” and “false negative”. In addition, we introduced our recent algorithm to build maximum-unbiased benchmarking sets applicable to both ligand-based and structure-based VS approaches, and its implementations to three important human histone deacetylase (HDAC) isoforms, i.e. HDAC1, HDAC6 and HDAC8. The Leave-One-Out Cross-Validation (LOO CV) demonstrates that the benchmarking sets built by our algorithm are maximum-unbiased in terms of property matching, ROC curves and AUCs. PMID:25481478

Benchmarking methods and data sets for ligand enrichment assessment in virtual screening.

Science.gov (United States)

Xia, Jie; Tilahun, Ermias Lemma; Reid, Terry-Elinor; Zhang, Liangren; Wang, Xiang Simon

2015-01-01

Retrospective small-scale virtual screening (VS) based on benchmarking data sets has been widely used to estimate ligand enrichments of VS approaches in the prospective (i.e. real-world) efforts. However, the intrinsic differences of benchmarking sets to the real screening chemical libraries can cause biased assessment. Herein, we summarize the history of benchmarking methods as well as data sets and highlight three main types of biases found in benchmarking sets, i.e. "analogue bias", "artificial enrichment" and "false negative". In addition, we introduce our recent algorithm to build maximum-unbiased benchmarking sets applicable to both ligand-based and structure-based VS approaches, and its implementations to three important human histone deacetylases (HDACs) isoforms, i.e. HDAC1, HDAC6 and HDAC8. The leave-one-out cross-validation (LOO CV) demonstrates that the benchmarking sets built by our algorithm are maximum-unbiased as measured by property matching, ROC curves and AUCs. Copyright © 2014 Elsevier Inc. All rights reserved.

Gamma ray benchmark on the spent fuel shipping cask TN 12

International Nuclear Information System (INIS)

Blum, P.; Cagnon, R.; Cladel, C.; Ermont, G.; Nimal, J.C.

1983-05-01

The purpose of this benchmark is to compare measurements and calculation of gamma-ray dose rates around a shipping cask loaded with 12 spent fuel elements of FESSENHEIM PWR type. The benchmark provides a means to verify gamma-ray sources and gamma-ray transport calculation methods in shipping cask configurations. The comparison between measurements and calculations shows a good agreement except near the fuel element top where the discrepancy reaches a factor 2

An international pooled analysis for obtaining a benchmark dose for environmental lead exposure in children

DEFF Research Database (Denmark)

Budtz-Jørgensen, Esben; Bellinger, David; Lanphear, Bruce

2013-01-01

Lead is a recognized neurotoxicant, but estimating effects at the lowest measurable levels is difficult. An international pooled analysis of data from seven cohort studies reported an inverse and supra-linear relationship between blood lead concentrations and IQ scores in children. The lack...... of a clear threshold presents a challenge to the identification of an acceptable level of exposure. The benchmark dose (BMD) is defined as the dose that leads to a specific known loss. As an alternative to elusive thresholds, the BMD is being used increasingly by regulatory authorities. Using the pooled data...... yielding lower confidence limits (BMDLs) of about 0.1-1.0 μ g/dL for the dose leading to a loss of one IQ point. We conclude that current allowable blood lead concentrations need to be lowered and further prevention efforts are needed to protect children from lead toxicity....

Use of benchmark dose-volume histograms for selection of the optimal technique between three-dimensional conformal radiation therapy and intensity-modulated radiation therapy in prostate cancer

International Nuclear Information System (INIS)

Luo Chunhui; Yang, Claus Chunli; Narayan, Samir; Stern, Robin L.; Perks, Julian; Goldberg, Zelanna; Ryu, Janice; Purdy, James A.; Vijayakumar, Srinivasan

2006-01-01

Purpose: The aim of this study was to develop and validate our own benchmark dose-volume histograms (DVHs) of bladder and rectum for both conventional three-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT), and to evaluate quantitatively the benefits of using IMRT vs. 3D-CRT in treating localized prostate cancer. Methods and Materials: During the implementation of IMRT for prostate cancer, our policy was to plan each patient with both 3D-CRT and IMRT. This study included 31 patients with T1b to T2c localized prostate cancer, for whom we completed double-planning using both 3D-CRT and IMRT techniques. The target volumes included prostate, either with or without proximal seminal vesicles. Bladder and rectum DVH data were summarized to obtain an average DVH for each technique and then compared using two-tailed paired t test analysis. Results: For 3D-CRT our bladder doses were as follows: mean 28.8 Gy, v60 16.4%, v70 10.9%; rectal doses were: mean 39.3 Gy, v60 21.8%, v70 13.6%. IMRT plans resulted in similar mean dose values: bladder 26.4 Gy, rectum 34.9 Gy, but lower values of v70 for the bladder (7.8%) and rectum (9.3%). These benchmark DVHs have resulted in a critical evaluation of our 3D-CRT techniques over time. Conclusion: Our institution has developed benchmark DVHs for bladder and rectum based on our clinical experience with 3D-CRT and IMRT. We use these standards as well as differences in individual cases to make decisions on whether patients may benefit from IMRT treatment rather than 3D-CRT

Benchmarking local healthcare-associated infections: Available benchmarks and interpretation challenges

Directory of Open Access Journals (Sweden)

Aiman El-Saed

2013-10-01

Full Text Available Summary: Growing numbers of healthcare facilities are routinely collecting standardized data on healthcare-associated infection (HAI, which can be used not only to track internal performance but also to compare local data to national and international benchmarks. Benchmarking overall (crude HAI surveillance metrics without accounting or adjusting for potential confounders can result in misleading conclusions. Methods commonly used to provide risk-adjusted metrics include multivariate logistic regression analysis, stratification, indirect standardization, and restrictions. The characteristics of recognized benchmarks worldwide, including the advantages and limitations are described. The choice of the right benchmark for the data from the Gulf Cooperation Council (GCC states is challenging. The chosen benchmark should have similar data collection and presentation methods. Additionally, differences in surveillance environments including regulations should be taken into consideration when considering such a benchmark. The GCC center for infection control took some steps to unify HAI surveillance systems in the region. GCC hospitals still need to overcome legislative and logistic difficulties in sharing data to create their own benchmark. The availability of a regional GCC benchmark may better enable health care workers and researchers to obtain more accurate and realistic comparisons. Keywords: Benchmarking, Comparison, Surveillance, Healthcare-associated infections

Method of characteristics - Based sensitivity calculations for international PWR benchmark

International Nuclear Information System (INIS)

Suslov, I. R.; Tormyshev, I. V.; Komlev, O. G.

2013-01-01

Method to calculate sensitivity of fractional-linear neutron flux functionals to transport equation coefficients is proposed. Implementation of the method on the basis of MOC code MCCG3D is developed. Sensitivity calculations for fission intensity for international PWR benchmark are performed. (authors)

Hand rub dose needed for a single disinfection varies according to product: A bias in benchmarking using indirect hand hygiene indicator

Directory of Open Access Journals (Sweden)

Raphaële Girard

2012-12-01

Results: Data from 27 products and 1706 tests were analyzed. Depending on the product, the dose needed to ensure a 30-s contact duration in 75% of tests ranging from 2 ml to more than 3 ml, and to ensure a contact duration exceeding the EN 1500 times in 75% of tests ranging from 1.5 ml to more than 3 ml. The aftermath interpretation is the following: if different products are used, the volume utilized does not give an unbiased estimation of the HH compliance. Other compliance evaluation methods remain necessary for efficient benchmarking.

A cross-benchmark comparison of 87 learning to rank methods

NARCIS (Netherlands)

Tax, N.; Bockting, S.; Hiemstra, D.

2015-01-01

Learning to rank is an increasingly important scientific field that comprises the use of machine learning for the ranking task. New learning to rank methods are generally evaluated on benchmark test collections. However, comparison of learning to rank methods based on evaluation results is hindered

Benchmarking Benchmarks

NARCIS (Netherlands)

D.C. Blitz (David)

2011-01-01

textabstractBenchmarking benchmarks is a bundle of six studies that are inspired by the prevalence of benchmarking in academic finance research as well as in investment practice. Three studies examine if current benchmark asset pricing models adequately describe the cross-section of stock returns.

CompaRNA: a server for continuous benchmarking of automated methods for RNA secondary structure prediction

Science.gov (United States)

Puton, Tomasz; Kozlowski, Lukasz P.; Rother, Kristian M.; Bujnicki, Janusz M.

2013-01-01

We present a continuous benchmarking approach for the assessment of RNA secondary structure prediction methods implemented in the CompaRNA web server. As of 3 October 2012, the performance of 28 single-sequence and 13 comparative methods has been evaluated on RNA sequences/structures released weekly by the Protein Data Bank. We also provide a static benchmark generated on RNA 2D structures derived from the RNAstrand database. Benchmarks on both data sets offer insight into the relative performance of RNA secondary structure prediction methods on RNAs of different size and with respect to different types of structure. According to our tests, on the average, the most accurate predictions obtained by a comparative approach are generated by CentroidAlifold, MXScarna, RNAalifold and TurboFold. On the average, the most accurate predictions obtained by single-sequence analyses are generated by CentroidFold, ContextFold and IPknot. The best comparative methods typically outperform the best single-sequence methods if an alignment of homologous RNA sequences is available. This article presents the results of our benchmarks as of 3 October 2012, whereas the rankings presented online are continuously updated. We will gladly include new prediction methods and new measures of accuracy in the new editions of CompaRNA benchmarks. PMID:23435231

CompaRNA: a server for continuous benchmarking of automated methods for RNA secondary structure prediction.

Science.gov (United States)

Puton, Tomasz; Kozlowski, Lukasz P; Rother, Kristian M; Bujnicki, Janusz M

2013-04-01

We present a continuous benchmarking approach for the assessment of RNA secondary structure prediction methods implemented in the CompaRNA web server. As of 3 October 2012, the performance of 28 single-sequence and 13 comparative methods has been evaluated on RNA sequences/structures released weekly by the Protein Data Bank. We also provide a static benchmark generated on RNA 2D structures derived from the RNAstrand database. Benchmarks on both data sets offer insight into the relative performance of RNA secondary structure prediction methods on RNAs of different size and with respect to different types of structure. According to our tests, on the average, the most accurate predictions obtained by a comparative approach are generated by CentroidAlifold, MXScarna, RNAalifold and TurboFold. On the average, the most accurate predictions obtained by single-sequence analyses are generated by CentroidFold, ContextFold and IPknot. The best comparative methods typically outperform the best single-sequence methods if an alignment of homologous RNA sequences is available. This article presents the results of our benchmarks as of 3 October 2012, whereas the rankings presented online are continuously updated. We will gladly include new prediction methods and new measures of accuracy in the new editions of CompaRNA benchmarks.

Semiempirical Quantum-Chemical Orthogonalization-Corrected Methods: Benchmarks for Ground-State Properties.

Science.gov (United States)

Dral, Pavlo O; Wu, Xin; Spörkel, Lasse; Koslowski, Axel; Thiel, Walter

2016-03-08

The semiempirical orthogonalization-corrected OMx methods (OM1, OM2, and OM3) go beyond the standard MNDO model by including additional interactions in the electronic structure calculation. When augmented with empirical dispersion corrections, the resulting OMx-Dn approaches offer a fast and robust treatment of noncovalent interactions. Here we evaluate the performance of the OMx and OMx-Dn methods for a variety of ground-state properties using a large and diverse collection of benchmark sets from the literature, with a total of 13035 original and derived reference data. Extensive comparisons are made with the results from established semiempirical methods (MNDO, AM1, PM3, PM6, and PM7) that also use the NDDO (neglect of diatomic differential overlap) integral approximation. Statistical evaluations show that the OMx and OMx-Dn methods outperform the other methods for most of the benchmark sets.

GeneNetWeaver: in silico benchmark generation and performance profiling of network inference methods.

Science.gov (United States)

Schaffter, Thomas; Marbach, Daniel; Floreano, Dario

2011-08-15

Over the last decade, numerous methods have been developed for inference of regulatory networks from gene expression data. However, accurate and systematic evaluation of these methods is hampered by the difficulty of constructing adequate benchmarks and the lack of tools for a differentiated analysis of network predictions on such benchmarks. Here, we describe a novel and comprehensive method for in silico benchmark generation and performance profiling of network inference methods available to the community as an open-source software called GeneNetWeaver (GNW). In addition to the generation of detailed dynamical models of gene regulatory networks to be used as benchmarks, GNW provides a network motif analysis that reveals systematic prediction errors, thereby indicating potential ways of improving inference methods. The accuracy of network inference methods is evaluated using standard metrics such as precision-recall and receiver operating characteristic curves. We show how GNW can be used to assess the performance and identify the strengths and weaknesses of six inference methods. Furthermore, we used GNW to provide the international Dialogue for Reverse Engineering Assessments and Methods (DREAM) competition with three network inference challenges (DREAM3, DREAM4 and DREAM5). GNW is available at http://gnw.sourceforge.net along with its Java source code, user manual and supporting data. Supplementary data are available at Bioinformatics online. dario.floreano@epfl.ch.

Development of a set of benchmark problems to verify numerical methods for solving burnup equations

International Nuclear Information System (INIS)

Lago, Daniel; Rahnema, Farzad

2017-01-01

Highlights: • Description transmutation chain benchmark problems. • Problems for validating numerical methods for solving burnup equations. • Analytical solutions for the burnup equations. • Numerical solutions for the burnup equations. - Abstract: A comprehensive set of transmutation chain benchmark problems for numerically validating methods for solving burnup equations was created. These benchmark problems were designed to challenge both traditional and modern numerical methods used to solve the complex set of ordinary differential equations used for tracking the change in nuclide concentrations over time due to nuclear phenomena. Given the development of most burnup solvers is done for the purpose of coupling with an established transport solution method, these problems provide a useful resource in testing and validating the burnup equation solver before coupling for use in a lattice or core depletion code. All the relevant parameters for each benchmark problem are described. Results are also provided in the form of reference solutions generated by the Mathematica tool, as well as additional numerical results from MATLAB.

Benchmarking and Performance Measurement.

Science.gov (United States)

Town, J. Stephen

This paper defines benchmarking and its relationship to quality management, describes a project which applied the technique in a library context, and explores the relationship between performance measurement and benchmarking. Numerous benchmarking methods contain similar elements: deciding what to benchmark; identifying partners; gathering…

Review of California and National Methods for Energy PerformanceBenchmarking of Commercial Buildings

Energy Technology Data Exchange (ETDEWEB)

Matson, Nance E.; Piette, Mary Ann

2005-09-05

This benchmarking review has been developed to support benchmarking planning and tool development under discussion by the California Energy Commission (CEC), Lawrence Berkeley National Laboratory (LBNL) and others in response to the Governor's Executive Order S-20-04 (2004). The Executive Order sets a goal of benchmarking and improving the energy efficiency of California's existing commercial building stock. The Executive Order requires the CEC to propose ''a simple building efficiency benchmarking system for all commercial buildings in the state''. This report summarizes and compares two currently available commercial building energy-benchmarking tools. One tool is the U.S. Environmental Protection Agency's Energy Star National Energy Performance Rating System, which is a national regression-based benchmarking model (referred to in this report as Energy Star). The second is Lawrence Berkeley National Laboratory's Cal-Arch, which is a California-based distributional model (referred to as Cal-Arch). Prior to the time Cal-Arch was developed in 2002, there were several other benchmarking tools available to California consumers but none that were based solely on California data. The Energy Star and Cal-Arch benchmarking tools both provide California with unique and useful methods to benchmark the energy performance of California's buildings. Rather than determine which model is ''better'', the purpose of this report is to understand and compare the underlying data, information systems, assumptions, and outcomes of each model.

RISKIND verification and benchmark comparisons

Energy Technology Data Exchange (ETDEWEB)

Biwer, B.M.; Arnish, J.J.; Chen, S.Y.; Kamboj, S.

1997-08-01

This report presents verification calculations and benchmark comparisons for RISKIND, a computer code designed to estimate potential radiological consequences and health risks to individuals and the population from exposures associated with the transportation of spent nuclear fuel and other radioactive materials. Spreadsheet calculations were performed to verify the proper operation of the major options and calculational steps in RISKIND. The program is unique in that it combines a variety of well-established models into a comprehensive treatment for assessing risks from the transportation of radioactive materials. Benchmark comparisons with other validated codes that incorporate similar models were also performed. For instance, the external gamma and neutron dose rate curves for a shipping package estimated by RISKIND were compared with those estimated by using the RADTRAN 4 code and NUREG-0170 methodology. Atmospheric dispersion of released material and dose estimates from the GENII and CAP88-PC codes. Verification results have shown the program to be performing its intended function correctly. The benchmark results indicate that the predictions made by RISKIND are within acceptable limits when compared with predictions from similar existing models.

RISKIND verification and benchmark comparisons

International Nuclear Information System (INIS)

Biwer, B.M.; Arnish, J.J.; Chen, S.Y.; Kamboj, S.

1997-08-01

This report presents verification calculations and benchmark comparisons for RISKIND, a computer code designed to estimate potential radiological consequences and health risks to individuals and the population from exposures associated with the transportation of spent nuclear fuel and other radioactive materials. Spreadsheet calculations were performed to verify the proper operation of the major options and calculational steps in RISKIND. The program is unique in that it combines a variety of well-established models into a comprehensive treatment for assessing risks from the transportation of radioactive materials. Benchmark comparisons with other validated codes that incorporate similar models were also performed. For instance, the external gamma and neutron dose rate curves for a shipping package estimated by RISKIND were compared with those estimated by using the RADTRAN 4 code and NUREG-0170 methodology. Atmospheric dispersion of released material and dose estimates from the GENII and CAP88-PC codes. Verification results have shown the program to be performing its intended function correctly. The benchmark results indicate that the predictions made by RISKIND are within acceptable limits when compared with predictions from similar existing models

Benchmarking the minimum Electron Beam (eBeam) dose required for the sterilization of space foods

Science.gov (United States)

Bhatia, Sohini S.; Wall, Kayley R.; Kerth, Chris R.; Pillai, Suresh D.

2018-02-01

As manned space missions extend in length, the safety, nutrition, acceptability, and shelf life of space foods are of paramount importance to NASA. Since food and mealtimes play a key role in reducing stress and boredom of prolonged missions, the quality of food in terms of appearance, flavor, texture, and aroma can have significant psychological ramifications on astronaut performance. The FDA, which oversees space foods, currently requires a minimum dose of 44 kGy for irradiated space foods. The underlying hypothesis was that commercial sterility of space foods could be achieved at a significantly lower dose, and this lowered dose would positively affect the shelf life of the product. Electron beam processed beef fajitas were used as an example NASA space food to benchmark the minimum eBeam dose required for sterility. A 15 kGy dose was able to achieve an approximately 10 log reduction in Shiga-toxin-producing Escherichia coli bacteria, and a 5 log reduction in Clostridium sporogenes spores. Furthermore, accelerated shelf life testing (ASLT) to determine sensory and quality characteristics under various conditions was conducted. Using Multidimensional gas-chromatography-olfactometry-mass spectrometry (MDGC-O-MS), numerous volatiles were shown to be dependent on the dose applied to the product. Furthermore, concentrations of off -flavor aroma compounds such as dimethyl sulfide were decreased at the reduced 15 kGy dose. The results suggest that the combination of conventional cooking combined with eBeam processing (15 kGy) can achieve the safety and shelf-life objectives needed for long duration space-foods.

Framework for benchmarking online retailing performance using fuzzy AHP and TOPSIS method

Directory of Open Access Journals (Sweden)

M. Ahsan Akhtar Hasin

2012-08-01

Full Text Available Due to increasing penetration of internet connectivity, on-line retail is growing from the pioneer phase to increasing integration within people's lives and companies' normal business practices. In the increasingly competitive environment, on-line retail service providers require systematic and structured approach to have cutting edge over the rival. Thus, the use of benchmarking has become indispensable to accomplish superior performance to support the on-line retail service providers. This paper uses the fuzzy analytic hierarchy process (FAHP approach to support a generic on-line retail benchmarking process. Critical success factors for on-line retail service have been identified from a structured questionnaire and literature and prioritized using fuzzy AHP. Using these critical success factors, performance levels of the ORENET an on-line retail service provider is benchmarked along with four other on-line service providers using TOPSIS method. Based on the benchmark, their relative ranking has also been illustrated.

Deterministic absorbed dose estimation in computed tomography using a discrete ordinates method

International Nuclear Information System (INIS)

Norris, Edward T.; Liu, Xin; Hsieh, Jiang

2015-01-01

Purpose: Organ dose estimation for a patient undergoing computed tomography (CT) scanning is very important. Although Monte Carlo methods are considered gold-standard in patient dose estimation, the computation time required is formidable for routine clinical calculations. Here, the authors instigate a deterministic method for estimating an absorbed dose more efficiently. Methods: Compared with current Monte Carlo methods, a more efficient approach to estimating the absorbed dose is to solve the linear Boltzmann equation numerically. In this study, an axial CT scan was modeled with a software package, Denovo, which solved the linear Boltzmann equation using the discrete ordinates method. The CT scanning configuration included 16 x-ray source positions, beam collimators, flat filters, and bowtie filters. The phantom was the standard 32 cm CT dose index (CTDI) phantom. Four different Denovo simulations were performed with different simulation parameters, including the number of quadrature sets and the order of Legendre polynomial expansions. A Monte Carlo simulation was also performed for benchmarking the Denovo simulations. A quantitative comparison was made of the simulation results obtained by the Denovo and the Monte Carlo methods. Results: The difference in the simulation results of the discrete ordinates method and those of the Monte Carlo methods was found to be small, with a root-mean-square difference of around 2.4%. It was found that the discrete ordinates method, with a higher order of Legendre polynomial expansions, underestimated the absorbed dose near the center of the phantom (i.e., low dose region). Simulations of the quadrature set 8 and the first order of the Legendre polynomial expansions proved to be the most efficient computation method in the authors’ study. The single-thread computation time of the deterministic simulation of the quadrature set 8 and the first order of the Legendre polynomial expansions was 21 min on a personal computer

Is the assumption of normality or log-normality for continuous response data critical for benchmark dose estimation?

International Nuclear Information System (INIS)

Shao, Kan; Gift, Jeffrey S.; Setzer, R. Woodrow

2013-01-01

Continuous responses (e.g. body weight) are widely used in risk assessment for determining the benchmark dose (BMD) which is used to derive a U.S. EPA reference dose. One critical question that is not often addressed in dose–response assessments is whether to model the continuous data as normally or log-normally distributed. Additionally, if lognormality is assumed, and only summarized response data (i.e., mean ± standard deviation) are available as is usual in the peer-reviewed literature, the BMD can only be approximated. In this study, using the “hybrid” method and relative deviation approach, we first evaluate six representative continuous dose–response datasets reporting individual animal responses to investigate the impact on BMD/BMDL estimates of (1) the distribution assumption and (2) the use of summarized versus individual animal data when a log-normal distribution is assumed. We also conduct simulation studies evaluating model fits to various known distributions to investigate whether the distribution assumption has influence on BMD/BMDL estimates. Our results indicate that BMDs estimated using the hybrid method are more sensitive to the distribution assumption than counterpart BMDs estimated using the relative deviation approach. The choice of distribution assumption has limited impact on the BMD/BMDL estimates when the within dose-group variance is small, while the lognormality assumption is a better choice for relative deviation method when data are more skewed because of its appropriateness in describing the relationship between mean and standard deviation. Additionally, the results suggest that the use of summarized data versus individual response data to characterize log-normal distributions has minimal impact on BMD estimates. - Highlights: • We investigate to what extent the distribution assumption can affect BMD estimates. • Both real data analysis and simulation study are conducted. • BMDs estimated using hybrid method are more

Is the assumption of normality or log-normality for continuous response data critical for benchmark dose estimation?

Energy Technology Data Exchange (ETDEWEB)

Shao, Kan, E-mail: Shao.Kan@epa.gov [ORISE Postdoctoral Fellow, National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Gift, Jeffrey S. [National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States); Setzer, R. Woodrow [National Center for Computational Toxicology, U.S. Environmental Protection Agency, Research Triangle Park, NC (United States)

2013-11-01

Continuous responses (e.g. body weight) are widely used in risk assessment for determining the benchmark dose (BMD) which is used to derive a U.S. EPA reference dose. One critical question that is not often addressed in dose–response assessments is whether to model the continuous data as normally or log-normally distributed. Additionally, if lognormality is assumed, and only summarized response data (i.e., mean ± standard deviation) are available as is usual in the peer-reviewed literature, the BMD can only be approximated. In this study, using the “hybrid” method and relative deviation approach, we first evaluate six representative continuous dose–response datasets reporting individual animal responses to investigate the impact on BMD/BMDL estimates of (1) the distribution assumption and (2) the use of summarized versus individual animal data when a log-normal distribution is assumed. We also conduct simulation studies evaluating model fits to various known distributions to investigate whether the distribution assumption has influence on BMD/BMDL estimates. Our results indicate that BMDs estimated using the hybrid method are more sensitive to the distribution assumption than counterpart BMDs estimated using the relative deviation approach. The choice of distribution assumption has limited impact on the BMD/BMDL estimates when the within dose-group variance is small, while the lognormality assumption is a better choice for relative deviation method when data are more skewed because of its appropriateness in describing the relationship between mean and standard deviation. Additionally, the results suggest that the use of summarized data versus individual response data to characterize log-normal distributions has minimal impact on BMD estimates. - Highlights: • We investigate to what extent the distribution assumption can affect BMD estimates. • Both real data analysis and simulation study are conducted. • BMDs estimated using hybrid method are more

Benchmarking and validation of a Geant4-SHADOW Monte Carlo simulation for dose calculations in microbeam radiation therapy.

Science.gov (United States)

Cornelius, Iwan; Guatelli, Susanna; Fournier, Pauline; Crosbie, Jeffrey C; Sanchez Del Rio, Manuel; Bräuer-Krisch, Elke; Rosenfeld, Anatoly; Lerch, Michael

2014-05-01

Microbeam radiation therapy (MRT) is a synchrotron-based radiotherapy modality that uses high-intensity beams of spatially fractionated radiation to treat tumours. The rapid evolution of MRT towards clinical trials demands accurate treatment planning systems (TPS), as well as independent tools for the verification of TPS calculated dose distributions in order to ensure patient safety and treatment efficacy. Monte Carlo computer simulation represents the most accurate method of dose calculation in patient geometries and is best suited for the purpose of TPS verification. A Monte Carlo model of the ID17 biomedical beamline at the European Synchrotron Radiation Facility has been developed, including recent modifications, using the Geant4 Monte Carlo toolkit interfaced with the SHADOW X-ray optics and ray-tracing libraries. The code was benchmarked by simulating dose profiles in water-equivalent phantoms subject to irradiation by broad-beam (without spatial fractionation) and microbeam (with spatial fractionation) fields, and comparing against those calculated with a previous model of the beamline developed using the PENELOPE code. Validation against additional experimental dose profiles in water-equivalent phantoms subject to broad-beam irradiation was also performed. Good agreement between codes was observed, with the exception of out-of-field doses and toward the field edge for larger field sizes. Microbeam results showed good agreement between both codes and experimental results within uncertainties. Results of the experimental validation showed agreement for different beamline configurations. The asymmetry in the out-of-field dose profiles due to polarization effects was also investigated, yielding important information for the treatment planning process in MRT. This work represents an important step in the development of a Monte Carlo-based independent verification tool for treatment planning in MRT.

Safety objectives for nuclear power plants in terms of dose-frequency targets; a comparison exercise performed by the Commission of the European Communities on dose assessment within a licencing framework

International Nuclear Information System (INIS)

Lange, F.; Tolley, B.; Kelly, N.; Harbison, S.; Gilby, E.

1987-01-01

The Task Force on Safety Objectives (T.F.S.O.) of the CEC has initiated a benchmark exercise with the purpose to review the methods and data used in dose assessment being adopted in various countries to estimate doses from design basis accidents of nuclear power plants within a regulatory framework. This benchmark exercise forms one of the initiatives of the T.F.S.O. to enable a comprehensive intercomparison of the degree of coherence between the dose-frequency targets used in different Members States for application to design basis accidents. The structure, contents and results of the benchmark exercise in which eight countries/institutions participated are described. Some of the more important findings and conclusions and the relation to a parallel benchmark exercise on source terms for design basis accidents are discussed. (orig.)

Regulatory Benchmarking

DEFF Research Database (Denmark)

Agrell, Per J.; Bogetoft, Peter

2017-01-01

Benchmarking methods, and in particular Data Envelopment Analysis (DEA), have become well-established and informative tools for economic regulation. DEA is now routinely used by European regulators to set reasonable revenue caps for energy transmission and distribution system operators. The appli......Benchmarking methods, and in particular Data Envelopment Analysis (DEA), have become well-established and informative tools for economic regulation. DEA is now routinely used by European regulators to set reasonable revenue caps for energy transmission and distribution system operators....... The application of bench-marking in regulation, however, requires specific steps in terms of data validation, model specification and outlier detection that are not systematically documented in open publications, leading to discussions about regulatory stability and economic feasibility of these techniques...

Regulatory Benchmarking

DEFF Research Database (Denmark)

Agrell, Per J.; Bogetoft, Peter

2017-01-01

Benchmarking methods, and in particular Data Envelopment Analysis (DEA), have become well-established and informative tools for economic regulation. DEA is now routinely used by European regulators to set reasonable revenue caps for energy transmission and distribution system operators. The appli......Benchmarking methods, and in particular Data Envelopment Analysis (DEA), have become well-established and informative tools for economic regulation. DEA is now routinely used by European regulators to set reasonable revenue caps for energy transmission and distribution system operators....... The application of benchmarking in regulation, however, requires specific steps in terms of data validation, model specification and outlier detection that are not systematically documented in open publications, leading to discussions about regulatory stability and economic feasibility of these techniques...

The KMAT: Benchmarking Knowledge Management.

Science.gov (United States)

de Jager, Martha

Provides an overview of knowledge management and benchmarking, including the benefits and methods of benchmarking (e.g., competitive, cooperative, collaborative, and internal benchmarking). Arthur Andersen's KMAT (Knowledge Management Assessment Tool) is described. The KMAT is a collaborative benchmarking tool, designed to help organizations make…

Radiation transport benchmarks for simple geometries with void regions using the spherical harmonics method

International Nuclear Information System (INIS)

Kobayashi, K.

2009-01-01

In 2001, an international cooperation on the 3D radiation transport benchmarks for simple geometries with void region was performed under the leadership of E. Sartori of OECD/NEA. There were contributions from eight institutions, where 6 contributions were by the discrete ordinate method and only two were by the spherical harmonics method. The 3D spherical harmonics program FFT3 by the finite Fourier transformation method has been improved for this presentation, and benchmark solutions for the 2D and 3D simple geometries with void region by the FFT2 and FFT3 are given showing fairly good accuracy. (authors)

Benchmarking

OpenAIRE

Meylianti S., Brigita

1999-01-01

Benchmarking has different meaning to different people. There are five types of benchmarking, namely internal benchmarking, competitive benchmarking, industry / functional benchmarking, process / generic benchmarking and collaborative benchmarking. Each type of benchmarking has its own advantages as well as disadvantages. Therefore it is important to know what kind of benchmarking is suitable to a specific application. This paper will discuss those five types of benchmarking in detail, includ...

Multiscale benchmarking of drug delivery vectors.

Science.gov (United States)

Summers, Huw D; Ware, Matthew J; Majithia, Ravish; Meissner, Kenith E; Godin, Biana; Rees, Paul

2016-10-01

Cross-system comparisons of drug delivery vectors are essential to ensure optimal design. An in-vitro experimental protocol is presented that separates the role of the delivery vector from that of its cargo in determining the cell response, thus allowing quantitative comparison of different systems. The technique is validated through benchmarking of the dose-response of human fibroblast cells exposed to the cationic molecule, polyethylene imine (PEI); delivered as a free molecule and as a cargo on the surface of CdSe nanoparticles and Silica microparticles. The exposure metrics are converted to a delivered dose with the transport properties of the different scale systems characterized by a delivery time, τ. The benchmarking highlights an agglomeration of the free PEI molecules into micron sized clusters and identifies the metric determining cell death as the total number of PEI molecules presented to cells, determined by the delivery vector dose and the surface density of the cargo. Copyright © 2016 Elsevier Inc. All rights reserved.

Hand rub dose needed for a single disinfection varies according to product: a bias in benchmarking using indirect hand hygiene indicator.

Science.gov (United States)

Girard, Raphaële; Aupee, Martine; Erb, Martine; Bettinger, Anne; Jouve, Alice

2012-12-01

The 3ml volume currently used as the hand hygiene (HH) measure has been explored as the pertinent dose for an indirect indicator of HH compliance. A multicenter study was conducted in order to ascertain the required dose using different products. The average contact duration before drying was measured and compared with references. Effective hand coverage had to include the whole hand and the wrist. Two durations were chosen as points of reference: 30s, as given by guidelines, and the duration validated by the European standard EN 1500. Each product was to be tested, using standardized procedures, by three nosocomial infection prevention teams, for three different doses (3, 2 and 1.5ml). Data from 27 products and 1706 tests were analyzed. Depending on the product, the dose needed to ensure a 30-s contact duration in 75% of tests ranging from 2ml to more than 3ml, and to ensure a contact duration exceeding the EN 1500 times in 75% of tests ranging from 1.5ml to more than 3ml. The aftermath interpretation is the following: if different products are used, the volume utilized does not give an unbiased estimation of the HH compliance. Other compliance evaluation methods remain necessary for efficient benchmarking. Copyright © 2012 Ministry of Health, Saudi Arabia. Published by Elsevier Ltd. All rights reserved.

Benchmarking of epithermal methods in the lattice-physics code EPRI-CELL

International Nuclear Information System (INIS)

Williams, M.L.; Wright, R.Q.; Barhen, J.; Rothenstein, W.; Toney, B.

1982-01-01

The epithermal cross section shielding methods used in the lattice physics code EPRI-CELL (E-C) have been extensively studied to determine its major approximations and to examine the sensitivity of computed results to these approximations. The study has resulted in several improvements in the original methodology. These include: treatment of the external moderator source with intermediate resonance (IR) theory, development of a new Dancoff factor expression to account for clad interactions, development of a new method for treating resonance interference, and application of a generalized least squares method to compute best-estimate values for the Bell factor and group-dependent IR parameters. The modified E-C code with its new ENDF/B-V cross section library is tested for several numerical benchmark problems. Integral parameters computed by EC are compared with those obtained with point-cross section Monte Carlo calculations, and E-C fine group cross sections are benchmarked against point-cross section descrete ordinates calculations. It is found that the code modifications improve agreement between E-C and the more sophisticated methods. E-C shows excellent agreement on the integral parameters and usually agrees within a few percent on fine-group, shielded cross sections

Benchmarking state-of-the-art optical simulation methods for analyzing large nanophotonic structures

DEFF Research Database (Denmark)

Gregersen, Niels; de Lasson, Jakob Rosenkrantz; Frandsen, Lars Hagedorn

2018-01-01

Five computational methods are benchmarked by computing quality factors and resonance wavelengths inphotonic crystal membrane L5 and L9 line defect cavities. Careful convergence studies reveal that some methods are more suitable than others for analyzing these cavities....

RNAontheBENCH: computational and empirical resources for benchmarking RNAseq quantification and differential expression methods

KAUST Repository

Germain, Pierre-Luc

2016-06-20

RNA sequencing (RNAseq) has become the method of choice for transcriptome analysis, yet no consensus exists as to the most appropriate pipeline for its analysis, with current benchmarks suffering important limitations. Here, we address these challenges through a rich benchmarking resource harnessing (i) two RNAseq datasets including ERCC ExFold spike-ins; (ii) Nanostring measurements of a panel of 150 genes on the same samples; (iii) a set of internal, genetically-determined controls; (iv) a reanalysis of the SEQC dataset; and (v) a focus on relative quantification (i.e. across-samples). We use this resource to compare different approaches to each step of RNAseq analysis, from alignment to differential expression testing. We show that methods providing the best absolute quantification do not necessarily provide good relative quantification across samples, that count-based methods are superior for gene-level relative quantification, and that the new generation of pseudo-alignment-based software performs as well as established methods, at a fraction of the computing time. We also assess the impact of library type and size on quantification and differential expression analysis. Finally, we have created a R package and a web platform to enable the simple and streamlined application of this resource to the benchmarking of future methods.

RNAontheBENCH: computational and empirical resources for benchmarking RNAseq quantification and differential expression methods

KAUST Repository

Germain, Pierre-Luc; Vitriolo, Alessandro; Adamo, Antonio; Laise, Pasquale; Das, Vivek; Testa, Giuseppe

2016-01-01

RNA sequencing (RNAseq) has become the method of choice for transcriptome analysis, yet no consensus exists as to the most appropriate pipeline for its analysis, with current benchmarks suffering important limitations. Here, we address these challenges through a rich benchmarking resource harnessing (i) two RNAseq datasets including ERCC ExFold spike-ins; (ii) Nanostring measurements of a panel of 150 genes on the same samples; (iii) a set of internal, genetically-determined controls; (iv) a reanalysis of the SEQC dataset; and (v) a focus on relative quantification (i.e. across-samples). We use this resource to compare different approaches to each step of RNAseq analysis, from alignment to differential expression testing. We show that methods providing the best absolute quantification do not necessarily provide good relative quantification across samples, that count-based methods are superior for gene-level relative quantification, and that the new generation of pseudo-alignment-based software performs as well as established methods, at a fraction of the computing time. We also assess the impact of library type and size on quantification and differential expression analysis. Finally, we have created a R package and a web platform to enable the simple and streamlined application of this resource to the benchmarking of future methods.

A convolution method for predicting mean treatment dose including organ motion at imaging

International Nuclear Information System (INIS)

Booth, J.T.; Zavgorodni, S.F.; Royal Adelaide Hospital, SA

2000-01-01

Full text: The random treatment delivery errors (organ motion and set-up error) can be incorporated into the treatment planning software using a convolution method. Mean treatment dose is computed as the convolution of a static dose distribution with a variation kernel. Typically this variation kernel is Gaussian with variance equal to the sum of the organ motion and set-up error variances. We propose a novel variation kernel for the convolution technique that additionally considers the position of the mobile organ in the planning CT image. The systematic error of organ position in the planning CT image can be considered random for each patient over a population. Thus the variance of the variation kernel will equal the sum of treatment delivery variance and organ motion variance at planning for the population of treatments. The kernel is extended to deal with multiple pre-treatment CT scans to improve tumour localisation for planning. Mean treatment doses calculated with the convolution technique are compared to benchmark Monte Carlo (MC) computations. Calculations of mean treatment dose using the convolution technique agreed with MC results for all cases to better than ± 1 Gy in the planning treatment volume for a prescribed 60 Gy treatment. Convolution provides a quick method of incorporating random organ motion (captured in the planning CT image and during treatment delivery) and random set-up errors directly into the dose distribution. Copyright (2000) Australasian College of Physical Scientists and Engineers in Medicine

The Isprs Benchmark on Indoor Modelling

Science.gov (United States)

Khoshelham, K.; Díaz Vilariño, L.; Peter, M.; Kang, Z.; Acharya, D.

2017-09-01

Automated generation of 3D indoor models from point cloud data has been a topic of intensive research in recent years. While results on various datasets have been reported in literature, a comparison of the performance of different methods has not been possible due to the lack of benchmark datasets and a common evaluation framework. The ISPRS benchmark on indoor modelling aims to address this issue by providing a public benchmark dataset and an evaluation framework for performance comparison of indoor modelling methods. In this paper, we present the benchmark dataset comprising several point clouds of indoor environments captured by different sensors. We also discuss the evaluation and comparison of indoor modelling methods based on manually created reference models and appropriate quality evaluation criteria. The benchmark dataset is available for download at: html"target="_blank">http://www2.isprs.org/commissions/comm4/wg5/benchmark-on-indoor-modelling.html.

Investigation on method of elasto-plastic analysis for piping system (benchmark analysis)

International Nuclear Information System (INIS)

Kabaya, Takuro; Kojima, Nobuyuki; Arai, Masashi

2015-01-01

This paper provides method of an elasto-plastic analysis for practical seismic design of nuclear piping system. JSME started up the task to establish method of an elasto-plastic analysis for nuclear piping system. The benchmark analyses have been performed in the task to investigate on method of an elasto-plastic analysis. And our company has participated in the benchmark analyses. As a result, we have settled on the method which simulates the result of piping exciting test accurately. Therefore the recommended method of an elasto-plastic analysis is shown as follows; 1) An elasto-plastic analysis is composed of dynamic analysis of piping system modeled by using beam elements and static analysis of deformed elbow modeled by using shell elements. 2) Bi-linear is applied as an elasto-plastic property. Yield point is standardized yield point multiplied by 1.2 times, and second gradient is 1/100 young's modulus. Kinematic hardening is used as a hardening rule. 3) The fatigue life is evaluated on strain ranges obtained by elasto-plastic analysis, by using the rain flow method and the fatigue curve of previous studies. (author)

Benchmark analysis of MCNP trademark ENDF/B-VI iron

International Nuclear Information System (INIS)

Court, J.D.; Hendricks, J.S.

1994-12-01

The MCNP ENDF/B-VI iron cross-section data was subjected to four benchmark studies as part of the Hiroshima/Nagasaki dose re-evaluation for the National Academy of Science and the Defense Nuclear Agency. The four benchmark studies were: (1) the iron sphere benchmarks from the Lawrence Livermore Pulsed Spheres; (2) the Oak Ridge National Laboratory Fusion Reactor Shielding Benchmark; (3) a 76-cm diameter iron sphere benchmark done at the University of Illinois; (4) the Oak Ridge National Laboratory Benchmark for Neutron Transport through Iron. MCNP4A was used to model each benchmark and computational results from the ENDF/B-VI iron evaluations were compared to ENDF/B-IV, ENDF/B-V, the MCNP Recommended Data Set (which includes Los Alamos National Laboratory Group T-2 evaluations), and experimental data. The results show that the ENDF/B-VI iron evaluations are as good as, or better than, previous data sets

Benchmarking lattice physics data and methods for boiling water reactor analysis

International Nuclear Information System (INIS)

Cacciapouti, R.J.; Edenius, M.; Harris, D.R.; Hebert, M.J.; Kapitz, D.M.; Pilat, E.E.; VerPlanck, D.M.

1983-01-01

The objective of the work reported was to verify the adequacy of lattice physics modeling for the analysis of the Vermont Yankee BWR using a multigroup, two-dimensional transport theory code. The BWR lattice physics methods have been benchmarked against reactor physics experiments, higher order calculations, and actual operating data

Benchmarking electricity distribution

Energy Technology Data Exchange (ETDEWEB)

Watts, K. [Department of Justice and Attorney-General, QLD (Australia)

1995-12-31

Benchmarking has been described as a method of continuous improvement that involves an ongoing and systematic evaluation and incorporation of external products, services and processes recognised as representing best practice. It is a management tool similar to total quality management (TQM) and business process re-engineering (BPR), and is best used as part of a total package. This paper discusses benchmarking models and approaches and suggests a few key performance indicators that could be applied to benchmarking electricity distribution utilities. Some recent benchmarking studies are used as examples and briefly discussed. It is concluded that benchmarking is a strong tool to be added to the range of techniques that can be used by electricity distribution utilities and other organizations in search of continuous improvement, and that there is now a high level of interest in Australia. Benchmarking represents an opportunity for organizations to approach learning from others in a disciplined and highly productive way, which will complement the other micro-economic reforms being implemented in Australia. (author). 26 refs.

An unbiased method to build benchmarking sets for ligand-based virtual screening and its application to GPCRs.

Science.gov (United States)

Xia, Jie; Jin, Hongwei; Liu, Zhenming; Zhang, Liangren; Wang, Xiang Simon

2014-05-27

Benchmarking data sets have become common in recent years for the purpose of virtual screening, though the main focus had been placed on the structure-based virtual screening (SBVS) approaches. Due to the lack of crystal structures, there is great need for unbiased benchmarking sets to evaluate various ligand-based virtual screening (LBVS) methods for important drug targets such as G protein-coupled receptors (GPCRs). To date these ready-to-apply data sets for LBVS are fairly limited, and the direct usage of benchmarking sets designed for SBVS could bring the biases to the evaluation of LBVS. Herein, we propose an unbiased method to build benchmarking sets for LBVS and validate it on a multitude of GPCRs targets. To be more specific, our methods can (1) ensure chemical diversity of ligands, (2) maintain the physicochemical similarity between ligands and decoys, (3) make the decoys dissimilar in chemical topology to all ligands to avoid false negatives, and (4) maximize spatial random distribution of ligands and decoys. We evaluated the quality of our Unbiased Ligand Set (ULS) and Unbiased Decoy Set (UDS) using three common LBVS approaches, with Leave-One-Out (LOO) Cross-Validation (CV) and a metric of average AUC of the ROC curves. Our method has greatly reduced the "artificial enrichment" and "analogue bias" of a published GPCRs benchmarking set, i.e., GPCR Ligand Library (GLL)/GPCR Decoy Database (GDD). In addition, we addressed an important issue about the ratio of decoys per ligand and found that for a range of 30 to 100 it does not affect the quality of the benchmarking set, so we kept the original ratio of 39 from the GLL/GDD.

Pre-evaluation of fusion shielding benchmark experiment

International Nuclear Information System (INIS)

Hayashi, K.; Handa, H.; Konno, C.

1994-01-01

Shielding benchmark experiment is very useful to test the design code and nuclear data for fusion devices. There are many types of benchmark experiments that should be done in fusion shielding problems, but time and budget are limited. Therefore it will be important to select and determine the effective experimental configurations by precalculation before the experiment. The authors did three types of pre-evaluation to determine the experimental assembly configurations of shielding benchmark experiments planned in FNS, JAERI. (1) Void Effect Experiment - The purpose of this experiment is to measure the local increase of dose and nuclear heating behind small void(s) in shield material. Dimension of the voids and its arrangements were decided as follows. Dose and nuclear heating were calculated both for with and without void(s). Minimum size of the void was determined so that the ratio of these two results may be larger than error of the measurement system. (2) Auxiliary Shield Experiment - The purpose of this experiment is to measure shielding properties of B 4 C, Pb, W, and dose around superconducting magnet (SCM). Thickness of B 4 C, Pb, W and their arrangement including multilayer configuration were determined. (3) SCM Nuclear Heating Experiment - The purpose of this experiment is to measure nuclear heating and dose distribution in SCM material. Because it is difficult to use liquid helium as a part of SCM mock up material, material composition of SCM mock up are surveyed to have similar nuclear heating property of real SCM composition

Benchmarking of EPRI-cell epithermal methods with the point-energy discrete-ordinates code (OZMA)

International Nuclear Information System (INIS)

Williams, M.L.; Wright, R.Q.; Barhen, J.; Rothenstein, W.

1982-01-01

The purpose of the present study is to benchmark E-C resonance-shielding and cell-averaging methods against a rigorous deterministic solution on a fine-group level (approx. 30 groups between 1 eV and 5.5 keV). The benchmark code used is OZMA, which solves the space-dependent slowing-down equations using continuous-energy discrete ordinates or integral transport theory to produce fine-group cross sections. Results are given for three water-moderated lattices - a mixed oxide, a uranium method, and a tight-pitch high-conversion uranium oxide configuration. The latter two lattices were chosen because of the strong self shielding of the 238 U resonances

Toxicological Benchmarks for Wildlife

Energy Technology Data Exchange (ETDEWEB)

Sample, B.E. Opresko, D.M. Suter, G.W.

1993-01-01

-tailed hawk, osprey) (scientific names for both the mammalian and avian species are presented in Appendix B). [In this document, NOAEL refers to both dose (mg contaminant per kg animal body weight per day) and concentration (mg contaminant per kg of food or L of drinking water)]. The 20 wildlife species were chosen because they are widely distributed and provide a representative range of body sizes and diets. The chemicals are some of those that occur at U.S. Department of Energy (DOE) waste sites. The NOAEL-based benchmarks presented in this report represent values believed to be nonhazardous for the listed wildlife species; LOAEL-based benchmarks represent threshold levels at which adverse effects are likely to become evident. These benchmarks consider contaminant exposure through oral ingestion of contaminated media only. Exposure through inhalation and/or direct dermal exposure are not considered in this report.

Benchmarking Swiss electricity grids

International Nuclear Information System (INIS)

Walti, N.O.; Weber, Ch.

2001-01-01

This extensive article describes a pilot benchmarking project initiated by the Swiss Association of Electricity Enterprises that assessed 37 Swiss utilities. The data collected from these utilities on a voluntary basis included data on technical infrastructure, investments and operating costs. These various factors are listed and discussed in detail. The assessment methods and rating mechanisms that provided the benchmarks are discussed and the results of the pilot study are presented that are to form the basis of benchmarking procedures for the grid regulation authorities under the planned Switzerland's electricity market law. Examples of the practical use of the benchmarking methods are given and cost-efficiency questions still open in the area of investment and operating costs are listed. Prefaces by the Swiss Association of Electricity Enterprises and the Swiss Federal Office of Energy complete the article

A Benchmark of Lidar-Based Single Tree Detection Methods Using Heterogeneous Forest Data from the Alpine Space

Directory of Open Access Journals (Sweden)

Lothar Eysn

2015-05-01

Full Text Available In this study, eight airborne laser scanning (ALS-based single tree detection methods are benchmarked and investigated. The methods were applied to a unique dataset originating from different regions of the Alpine Space covering different study areas, forest types, and structures. This is the first benchmark ever performed for different forests within the Alps. The evaluation of the detection results was carried out in a reproducible way by automatically matching them to precise in situ forest inventory data using a restricted nearest neighbor detection approach. Quantitative statistical parameters such as percentages of correctly matched trees and omission and commission errors are presented. The proposed automated matching procedure presented herein shows an overall accuracy of 97%. Method based analysis, investigations per forest type, and an overall benchmark performance are presented. The best matching rate was obtained for single-layered coniferous forests. Dominated trees were challenging for all methods. The overall performance shows a matching rate of 47%, which is comparable to results of other benchmarks performed in the past. The study provides new insight regarding the potential and limits of tree detection with ALS and underlines some key aspects regarding the choice of method when performing single tree detection for the various forest types encountered in alpine regions.

Shielding benchmark problems

International Nuclear Information System (INIS)

Tanaka, Shun-ichi; Sasamoto, Nobuo; Oka, Yoshiaki; Kawai, Masayoshi; Nakazawa, Masaharu.

1978-09-01

Shielding benchmark problems were prepared by the Working Group of Assessment of Shielding Experiments in the Research Comittee on Shielding Design of the Atomic Energy Society of Japan, and compiled by the Shielding Laboratory of Japan Atomic Energy Research Institute. Twenty-one kinds of shielding benchmark problems are presented for evaluating the calculational algorithm and the accuracy of computer codes based on the discrete ordinates method and the Monte Carlo method and for evaluating the nuclear data used in the codes. (author)

SU-E-T-148: Benchmarks and Pre-Treatment Reviews: A Study of Quality Assurance Effectiveness

International Nuclear Information System (INIS)

Lowenstein, J; Nguyen, H; Roll, J; Walsh, A; Tailor, A; Followill, D

2015-01-01

Purpose: To determine the impact benchmarks and pre-treatment reviews have on improving the quality of submitted clinical trial data. Methods: Benchmarks are used to evaluate a site’s ability to develop a treatment that meets a specific protocol’s treatment guidelines prior to placing their first patient on the protocol. A pre-treatment review is an actual patient placed on the protocol in which the dosimetry and contour volumes are evaluated to be per protocol guidelines prior to allowing the beginning of the treatment. A key component of these QA mechanisms is that sites are provided timely feedback to educate them on how to plan per the protocol and prevent protocol deviations on patients accrued to a protocol. For both benchmarks and pre-treatment reviews a dose volume analysis (DVA) was performed using MIM softwareTM. For pre-treatment reviews a volume contour evaluation was also performed. Results: IROC Houston performed a QA effectiveness analysis of a protocol which required both benchmarks and pre-treatment reviews. In 70 percent of the patient cases submitted, the benchmark played an effective role in assuring that the pre-treatment review of the cases met protocol requirements. The 35 percent of sites failing the benchmark subsequently modified there planning technique to pass the benchmark before being allowed to submit a patient for pre-treatment review. However, in 30 percent of the submitted cases the pre-treatment review failed where the majority (71 percent) failed the DVA. 20 percent of sites submitting patients failed to correct their dose volume discrepancies indicated by the benchmark case. Conclusion: Benchmark cases and pre-treatment reviews can be an effective QA tool to educate sites on protocol guidelines and to minimize deviations. Without the benchmark cases it is possible that 65 percent of the cases undergoing a pre-treatment review would have failed to meet the protocols requirements.Support: U24-CA-180803

Shielding benchmark problems, (2)

International Nuclear Information System (INIS)

Tanaka, Shun-ichi; Sasamoto, Nobuo; Oka, Yoshiaki; Shin, Kazuo; Tada, Keiko.

1980-02-01

Shielding benchmark problems prepared by Working Group of Assessment of Shielding Experiments in the Research Committee on Shielding Design in the Atomic Energy Society of Japan were compiled by Shielding Laboratory in Japan Atomic Energy Research Institute. Fourteen shielding benchmark problems are presented newly in addition to twenty-one problems proposed already, for evaluating the calculational algorithm and accuracy of computer codes based on discrete ordinates method and Monte Carlo method and for evaluating the nuclear data used in codes. The present benchmark problems are principally for investigating the backscattering and the streaming of neutrons and gamma rays in two- and three-dimensional configurations. (author)

Computational Chemistry Comparison and Benchmark Database

Science.gov (United States)

SRD 101 NIST Computational Chemistry Comparison and Benchmark Database (Web, free access)   The NIST Computational Chemistry Comparison and Benchmark Database is a collection of experimental and ab initio thermochemical properties for a selected set of molecules. The goals are to provide a benchmark set of molecules for the evaluation of ab initio computational methods and allow the comparison between different ab initio computational methods for the prediction of thermochemical properties.

Determining the sensitivity of Data Envelopment Analysis method used in airport benchmarking

Directory of Open Access Journals (Sweden)

Mircea BOSCOIANU

2013-03-01

Full Text Available In the last decade there were some important changes in the airport industry, caused by the liberalization of the air transportation market. Until recently airports were considered infrastructure elements, and they were evaluated only by traffic values or their maximum capacity. Gradual orientation towards commercial led to the need of finding another ways of evaluation, more efficiency oriented. The existing methods for assessing efficiency used for other production units were not suitable to be used in case of airports due to specific features and high complexity of airport operations. In the last years there were some papers that proposed the Data Envelopment Analysis as a method for assessing the operational efficiency in order to conduct the benchmarking. This method offers the possibility of dealing with a large number of variables of different types, which represents the main advantage of this method and also recommends it as a good benchmarking tool for the airports management. This paper goal is to determine the sensitivity of this method in relation with its inputs and outputs. A Data Envelopment Analysis is conducted for 128 airports worldwide, in both input- and output-oriented measures, and the results are analysed against some inputs and outputs variations. Possible weaknesses of using DEA for assessing airports performance are revealed and analysed against this method advantages.

Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Science.gov (United States)

Markowski, V P; Zareba, G; Stern, S; Cox, C; Weiss, B

2001-06-01

Pregnant Holtzman rats were exposed to a single oral dose of 0, 20, 60, or 180 ng/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the 18th day of gestation. Their adult female offspring were trained to respond on a lever for brief opportunities to run in specially designed running wheels. Once they had begun responding on a fixed-ratio 1 (FR1) schedule of reinforcement, the fixed-ratio requirement for lever pressing was increased at five-session intervals to values of FR2, FR5, FR10, FR20, and FR30. We examined vaginal cytology after each behavior session to track estrous cyclicity. Under each of the FR values, perinatal TCDD exposure produced a significant dose-related reduction in the number of earned opportunities to run, the lever response rate, and the total number of revolutions in the wheel. Estrous cyclicity was not affected. Because of the consistent dose-response relationship at all FR values, we used the behavioral data to calculate benchmark doses based on displacements from modeled zero-dose performance of 1% (ED(01)) and 10% (ED(10)), as determined by a quadratic fit to the dose-response function. The mean ED(10) benchmark dose for earned run opportunities was 10.13 ng/kg with a 95% lower bound of 5.77 ng/kg. The corresponding ED(01) was 0.98 ng/kg with a 95% lower bound of 0.83 ng/kg. The mean ED(10) for total wheel revolutions was calculated as 7.32 ng/kg with a 95% lower bound of 5.41 ng/kg. The corresponding ED(01) was 0.71 ng/kg with a 95% lower bound of 0.60. These values should be viewed from the perspective of current human body burdens, whose average value, based on TCDD toxic equivalents, has been calculated as 13 ng/kg.

Performance Benchmarking of Fast Multipole Methods

KAUST Repository

Al-Harthi, Noha A.

2013-06-01

The current trends in computer architecture are shifting towards smaller byte/flop ratios, while available parallelism is increasing at all levels of granularity – vector length, core count, and MPI process. Intel’s Xeon Phi coprocessor, NVIDIA’s Kepler GPU, and IBM’s BlueGene/Q all have a Byte/flop ratio close to 0.2, which makes it very difficult for most algorithms to extract a high percentage of the theoretical peak flop/s from these architectures. Popular algorithms in scientific computing such as FFT are continuously evolving to keep up with this trend in hardware. In the meantime it is also necessary to invest in novel algorithms that are more suitable for computer architectures of the future. The fast multipole method (FMM) was originally developed as a fast algorithm for ap- proximating the N-body interactions that appear in astrophysics, molecular dynamics, and vortex based fluid dynamics simulations. The FMM possesses have a unique combination of being an efficient O(N) algorithm, while having an operational intensity that is higher than a matrix-matrix multiplication. In fact, the FMM can reduce the requirement of Byte/flop to around 0.01, which means that it will remain compute bound until 2020 even if the cur- rent trend in microprocessors continues. Despite these advantages, there have not been any benchmarks of FMM codes on modern architectures such as Xeon Phi, Kepler, and Blue- Gene/Q. This study aims to provide a comprehensive benchmark of a state of the art FMM code “exaFMM” on the latest architectures, in hopes of providing a useful reference for deciding when the FMM will become useful as the computational engine in a given application code. It may also serve as a warning to certain problem size domains areas where the FMM will exhibit insignificant performance improvements. Such issues depend strongly on the asymptotic constants rather than the asymptotics themselves, and therefore are strongly implementation and hardware

Benchmarking of Remote Sensing Segmentation Methods

Czech Academy of Sciences Publication Activity Database

Mikeš, Stanislav; Haindl, Michal; Scarpa, G.; Gaetano, R.

2015-01-01

Roč. 8, č. 5 (2015), s. 2240-2248 ISSN 1939-1404 R&D Projects: GA ČR(CZ) GA14-10911S Institutional support: RVO:67985556 Keywords : benchmark * remote sensing segmentation * unsupervised segmentation * supervised segmentation Subject RIV: BD - Theory of Information Impact factor: 2.145, year: 2015 http://library.utia.cas.cz/separaty/2015/RO/haindl-0445995.pdf

Reliable B cell epitope predictions: impacts of method development and improved benchmarking

DEFF Research Database (Denmark)

Kringelum, Jens Vindahl; Lundegaard, Claus; Lund, Ole

2012-01-01

biomedical applications such as; rational vaccine design, development of disease diagnostics and immunotherapeutics. However, experimental mapping of epitopes is resource intensive making in silico methods an appealing complementary approach. To date, the reported performance of methods for in silico mapping...... evaluation data set improved from 0.712 to 0.727. Our results thus demonstrate that given proper benchmark definitions, B-cell epitope prediction methods achieve highly significant predictive performances suggesting these tools to be a powerful asset in rational epitope discovery. The updated version...

Prismatic Core Coupled Transient Benchmark

International Nuclear Information System (INIS)

Ortensi, J.; Pope, M.A.; Strydom, G.; Sen, R.S.; DeHart, M.D.; Gougar, H.D.; Ellis, C.; Baxter, A.; Seker, V.; Downar, T.J.; Vierow, K.; Ivanov, K.

2011-01-01

The Prismatic Modular Reactor (PMR) is one of the High Temperature Reactor (HTR) design concepts that have existed for some time. Several prismatic units have operated in the world (DRAGON, Fort St. Vrain, Peach Bottom) and one unit is still in operation (HTTR). The deterministic neutronics and thermal-fluids transient analysis tools and methods currently available for the design and analysis of PMRs have lagged behind the state of the art compared to LWR reactor technologies. This has motivated the development of more accurate and efficient tools for the design and safety evaluations of the PMR. In addition to the work invested in new methods, it is essential to develop appropriate benchmarks to verify and validate the new methods in computer codes. The purpose of this benchmark is to establish a well-defined problem, based on a common given set of data, to compare methods and tools in core simulation and thermal hydraulics analysis with a specific focus on transient events. The benchmark-working group is currently seeking OECD/NEA sponsorship. This benchmark is being pursued and is heavily based on the success of the PBMR-400 exercise.

California commercial building energy benchmarking

Energy Technology Data Exchange (ETDEWEB)

Kinney, Satkartar; Piette, Mary Ann

2003-07-01

Building energy benchmarking is the comparison of whole-building energy use relative to a set of similar buildings. It provides a useful starting point for individual energy audits and for targeting buildings for energy-saving measures in multiple-site audits. Benchmarking is of interest and practical use to a number of groups. Energy service companies and performance contractors communicate energy savings potential with ''typical'' and ''best-practice'' benchmarks while control companies and utilities can provide direct tracking of energy use and combine data from multiple buildings. Benchmarking is also useful in the design stage of a new building or retrofit to determine if a design is relatively efficient. Energy managers and building owners have an ongoing interest in comparing energy performance to others. Large corporations, schools, and government agencies with numerous facilities also use benchmarking methods to compare their buildings to each other. The primary goal of Task 2.1.1 Web-based Benchmarking was the development of a web-based benchmarking tool, dubbed Cal-Arch, for benchmarking energy use in California commercial buildings. While there were several other benchmarking tools available to California consumers prior to the development of Cal-Arch, there were none that were based solely on California data. Most available benchmarking information, including the Energy Star performance rating, were developed using DOE's Commercial Building Energy Consumption Survey (CBECS), which does not provide state-level data. Each database and tool has advantages as well as limitations, such as the number of buildings and the coverage by type, climate regions and end uses. There is considerable commercial interest in benchmarking because it provides an inexpensive method of screening buildings for tune-ups and retrofits. However, private companies who collect and manage consumption data are concerned that the

EGS4 benchmark program

International Nuclear Information System (INIS)

Yasu, Y.; Hirayama, H.; Namito, Y.; Yashiro, S.

1995-01-01

This paper proposes EGS4 Benchmark Suite which consists of three programs called UCSAMPL4, UCSAMPL4I and XYZDOS. This paper also evaluates optimization methods of recent RISC/UNIX systems, such as IBM, HP, DEC, Hitachi and Fujitsu, for the benchmark suite. When particular compiler option and math library were included in the evaluation process, system performed significantly better. Observed performance of some of the RISC/UNIX systems were beyond some so-called Mainframes of IBM, Hitachi or Fujitsu. The computer performance of EGS4 Code System on an HP9000/735 (99MHz) was defined to be the unit of EGS4 Unit. The EGS4 Benchmark Suite also run on various PCs such as Pentiums, i486 and DEC alpha and so forth. The performance of recent fast PCs reaches that of recent RISC/UNIX systems. The benchmark programs have been evaluated with correlation of industry benchmark programs, namely, SPECmark. (author)

Calculation methods for determining dose equivalent

International Nuclear Information System (INIS)

Endres, G.W.R.; Tanner, J.E.; Scherpelz, R.I.; Hadlock, D.E.

1987-11-01

A series of calculations of neutron fluence as a function of energy in an anthropomorphic phantom was performed to develop a system for determining effective dose equivalent for external radiation sources. Critical organ dose equivalents are calculated and effective dose equivalents are determined using ICRP-26 [1] methods. Quality factors based on both present definitions and ICRP-40 definitions are used in the analysis. The results of these calculations are presented and discussed. The effective dose equivalent determined using ICRP-26 methods is significantly smaller than the dose equivalent determined by traditional methods. No existing personnel dosimeter or health physics instrument can determine effective dose equivalent. At the present time, the conversion of dosimeter response to dose equivalent is based on calculations for maximal or ''cap'' values using homogeneous spherical or cylindrical phantoms. The evaluated dose equivalent is, therefore, a poor approximation of the effective dose equivalent as defined by ICRP Publication 26. 3 refs., 2 figs., 1 tab

Benchmark Studies of Induced Radioactivity Produced in LHC Materials, Pt II Specific Activities

International Nuclear Information System (INIS)

Brugger, M.; Mayer, S.; Roesler, S.; Ulrici, L.; Khater, H.; Prinz, A.; Vincke, H.

2006-01-01

A new method to estimate remanent dose rates, to be used with the Monte Carlo code FLUKA, was benchmarked against measurements from an experiment that was performed at the CERN-EU high-energy reference field facility. An extensive collection of samples of different materials were placed downstream of and laterally to a copper target, intercepting a positively charged mixed hadron beam with a momentum of 120 GeV/c. Emphasis was put on the reduction of uncertainties such as careful monitoring of the irradiation parameters, the use of different instruments to measure dose rates, detailed elemental analyses of the irradiated materials and detailed simulations of the irradiation experiment. Measured and calculated dose rates are in good agreement

Optimizing Radiation Doses for Computed Tomography Across Institutions: Dose Auditing and Best Practices.

Science.gov (United States)

Demb, Joshua; Chu, Philip; Nelson, Thomas; Hall, David; Seibert, Anthony; Lamba, Ramit; Boone, John; Krishnam, Mayil; Cagnon, Christopher; Bostani, Maryam; Gould, Robert; Miglioretti, Diana; Smith-Bindman, Rebecca

2017-06-01

Radiation doses for computed tomography (CT) vary substantially across institutions. To assess the impact of institutional-level audit and collaborative efforts to share best practices on CT radiation doses across 5 University of California (UC) medical centers. In this before/after interventional study, we prospectively collected radiation dose metrics on all diagnostic CT examinations performed between October 1, 2013, and December 31, 2014, at 5 medical centers. Using data from January to March (baseline), we created audit reports detailing the distribution of radiation dose metrics for chest, abdomen, and head CT scans. In April, we shared reports with the medical centers and invited radiology professionals from the centers to a 1.5-day in-person meeting to review reports and share best practices. We calculated changes in mean effective dose 12 weeks before and after the audits and meeting, excluding a 12-week implementation period when medical centers could make changes. We compared proportions of examinations exceeding previously published benchmarks at baseline and following the audit and meeting, and calculated changes in proportion of examinations exceeding benchmarks. Of 158 274 diagnostic CT scans performed in the study period, 29 594 CT scans were performed in the 3 months before and 32 839 CT scans were performed 12 to 24 weeks after the audit and meeting. Reductions in mean effective dose were considerable for chest and abdomen. Mean effective dose for chest CT decreased from 13.2 to 10.7 mSv (18.9% reduction; 95% CI, 18.0%-19.8%). Reductions at individual medical centers ranged from 3.8% to 23.5%. The mean effective dose for abdominal CT decreased from 20.0 to 15.0 mSv (25.0% reduction; 95% CI, 24.3%-25.8%). Reductions at individual medical centers ranged from 10.8% to 34.7%. The number of CT scans that had an effective dose measurement that exceeded benchmarks was reduced considerably by 48% and 54% for chest and abdomen, respectively. After

Methods of bone marrow dose calculation

International Nuclear Information System (INIS)

Taboaco, R.C.

1982-02-01

Several methods of bone marrow dose calculation for photon irradiation were analised. After a critical analysis, the author proposes the adoption, by the Instituto de Radioprotecao e Dosimetria/CNEN, of Rosenstein's method for dose calculations in Radiodiagnostic examinations and Kramer's method in case of occupational irradiation. It was verified by Eckerman and Simpson that for monoenergetic gamma emitters uniformly distributed within the bone mineral of the skeleton the dose in the bone surface can be several times higher than dose in skeleton. In this way, is also proposed the Calculation of tissue-air ratios for bone surfaces in some irradiation geometries and photon energies to be included in the Rosenstein's method for organ dose calculation in Radiodiagnostic examinations. (Author) [pt

Verification and validation benchmarks.

Energy Technology Data Exchange (ETDEWEB)

Oberkampf, William Louis; Trucano, Timothy Guy

2007-02-01

Verification and validation (V&V) are the primary means to assess the accuracy and reliability of computational simulations. V&V methods and procedures have fundamentally improved the credibility of simulations in several high-consequence fields, such as nuclear reactor safety, underground nuclear waste storage, and nuclear weapon safety. Although the terminology is not uniform across engineering disciplines, code verification deals with assessing the reliability of the software coding, and solution verification deals with assessing the numerical accuracy of the solution to a computational model. Validation addresses the physics modeling accuracy of a computational simulation by comparing the computational results with experimental data. Code verification benchmarks and validation benchmarks have been constructed for a number of years in every field of computational simulation. However, no comprehensive guidelines have been proposed for the construction and use of V&V benchmarks. For example, the field of nuclear reactor safety has not focused on code verification benchmarks, but it has placed great emphasis on developing validation benchmarks. Many of these validation benchmarks are closely related to the operations of actual reactors at near-safety-critical conditions, as opposed to being more fundamental-physics benchmarks. This paper presents recommendations for the effective design and use of code verification benchmarks based on manufactured solutions, classical analytical solutions, and highly accurate numerical solutions. In addition, this paper presents recommendations for the design and use of validation benchmarks, highlighting the careful design of building-block experiments, the estimation of experimental measurement uncertainty for both inputs and outputs to the code, validation metrics, and the role of model calibration in validation. It is argued that the understanding of predictive capability of a computational model is built on the level of

Anomaly detection in OECD Benchmark data using co-variance methods

International Nuclear Information System (INIS)

Srinivasan, G.S.; Krinizs, K.; Por, G.

1993-02-01

OECD Benchmark data distributed for the SMORN VI Specialists Meeting in Reactor Noise were investigated for anomaly detection in artificially generated reactor noise benchmark analysis. It was observed that statistical features extracted from covariance matrix of frequency components are very sensitive in terms of the anomaly detection level. It is possible to create well defined alarm levels. (R.P.) 5 refs.; 23 figs.; 1 tab

Netherlands contribution to the EC project: Benchmark exercise on dose estimation in a regulatory context

International Nuclear Information System (INIS)

Stolk, D.J.

1987-04-01

On request of the Netherlands government FEL-TNO is developing a decision support system with the acronym RAMBOS for the assessment of the off-site consequences of an accident with hazardous materials. This is a user friendly interactive computer program, which uses very sophisticated graphical means. RAMBOS supports the emergency planning organization in two ways. Firstly, the risk to the residents in the surroundings of the accident is quantified in terms of severity and magnitude (number of casualties, etc.). Secondly, the consequences of countermeasures, such as sheltering and evacuation, are predicted. By evaluating several countermeasures the user can determine an optimum policy to reduce the impact of the accident. Within the framework of the EC project 'Benchmark exercise on dose estimation in a regulatory context' on request of the Ministry of Housing, Physical Planning and Environment calculations were carried out with the RAMBOS system. This report contains the results of these calculations. 3 refs.; 2 figs.; 10 tabs

Benchmarking Foot Trajectory Estimation Methods for Mobile Gait Analysis

Directory of Open Access Journals (Sweden)

Julius Hannink

2017-08-01

Full Text Available Mobile gait analysis systems based on inertial sensing on the shoe are applied in a wide range of applications. Especially for medical applications, they can give new insights into motor impairment in, e.g., neurodegenerative disease and help objectify patient assessment. One key component in these systems is the reconstruction of the foot trajectories from inertial data. In literature, various methods for this task have been proposed. However, performance is evaluated on a variety of datasets due to the lack of large, generally accepted benchmark datasets. This hinders a fair comparison of methods. In this work, we implement three orientation estimation and three double integration schemes for use in a foot trajectory estimation pipeline. All methods are drawn from literature and evaluated against a marker-based motion capture reference. We provide a fair comparison on the same dataset consisting of 735 strides from 16 healthy subjects. As a result, the implemented methods are ranked and we identify the most suitable processing pipeline for foot trajectory estimation in the context of mobile gait analysis.

Mechanism-based risk assessment strategy for drug-induced cholestasis using the transcriptional benchmark dose derived by toxicogenomics.

Science.gov (United States)

Kawamoto, Taisuke; Ito, Yuichi; Morita, Osamu; Honda, Hiroshi

2017-01-01

Cholestasis is one of the major causes of drug-induced liver injury (DILI), which can result in withdrawal of approved drugs from the market. Early identification of cholestatic drugs is difficult due to the complex mechanisms involved. In order to develop a strategy for mechanism-based risk assessment of cholestatic drugs, we analyzed gene expression data obtained from the livers of rats that had been orally administered with 12 known cholestatic compounds repeatedly for 28 days at three dose levels. Qualitative analyses were performed using two statistical approaches (hierarchical clustering and principle component analysis), in addition to pathway analysis. The transcriptional benchmark dose (tBMD) and tBMD 95% lower limit (tBMDL) were used for quantitative analyses, which revealed three compound sub-groups that produced different types of differential gene expression; these groups of genes were mainly involved in inflammation, cholesterol biosynthesis, and oxidative stress. Furthermore, the tBMDL values for each test compound were in good agreement with the relevant no observed adverse effect level. These results indicate that our novel strategy for drug safety evaluation using mechanism-based classification and tBMDL would facilitate the application of toxicogenomics for risk assessment of cholestatic DILI.

Benchmarking: applications to transfusion medicine.

Science.gov (United States)

Apelseth, Torunn Oveland; Molnar, Laura; Arnold, Emmy; Heddle, Nancy M

2012-10-01

Benchmarking is as a structured continuous collaborative process in which comparisons for selected indicators are used to identify factors that, when implemented, will improve transfusion practices. This study aimed to identify transfusion medicine studies reporting on benchmarking, summarize the benchmarking approaches used, and identify important considerations to move the concept of benchmarking forward in the field of transfusion medicine. A systematic review of published literature was performed to identify transfusion medicine-related studies that compared at least 2 separate institutions or regions with the intention of benchmarking focusing on 4 areas: blood utilization, safety, operational aspects, and blood donation. Forty-five studies were included: blood utilization (n = 35), safety (n = 5), operational aspects of transfusion medicine (n = 5), and blood donation (n = 0). Based on predefined criteria, 7 publications were classified as benchmarking, 2 as trending, and 36 as single-event studies. Three models of benchmarking are described: (1) a regional benchmarking program that collects and links relevant data from existing electronic sources, (2) a sentinel site model where data from a limited number of sites are collected, and (3) an institutional-initiated model where a site identifies indicators of interest and approaches other institutions. Benchmarking approaches are needed in the field of transfusion medicine. Major challenges include defining best practices and developing cost-effective methods of data collection. For those interested in initiating a benchmarking program, the sentinel site model may be most effective and sustainable as a starting point, although the regional model would be the ideal goal. Copyright © 2012 Elsevier Inc. All rights reserved.

Classification of criticality calculations with correlation coefficient method and its application to OECD/NEA burnup credit benchmarks phase III-A and II-A

International Nuclear Information System (INIS)

Okuno, Hiroshi

2003-01-01

A method for classifying benchmark results of criticality calculations according to similarity was proposed in this paper. After formulation of the method utilizing correlation coefficients, it was applied to burnup credit criticality benchmarks Phase III-A and II-A, which were conducted by the Expert Group on Burnup Credit Criticality Safety under auspices of the Nuclear Energy Agency of the Organisation for Economic Cooperation and Development (OECD/NEA). Phase III-A benchmark was a series of criticality calculations for irradiated Boiling Water Reactor (BWR) fuel assemblies, whereas Phase II-A benchmark was a suite of criticality calculations for irradiated Pressurized Water Reactor (PWR) fuel pins. These benchmark problems and their results were summarized. The correlation coefficients were calculated and sets of benchmark calculation results were classified according to the criterion that the values of the correlation coefficients were no less than 0.15 for Phase III-A and 0.10 for Phase II-A benchmarks. When a couple of benchmark calculation results belonged to the same group, one calculation result was found predictable from the other. An example was shown for each of the Benchmarks. While the evaluated nuclear data seemed the main factor for the classification, further investigations were required for finding other factors. (author)

What is a food and what is a medicinal product in the European Union? Use of the benchmark dose (BMD) methodology to define a threshold for "pharmacological action".

Science.gov (United States)

Lachenmeier, Dirk W; Steffen, Christian; el-Atma, Oliver; Maixner, Sibylle; Löbell-Behrends, Sigrid; Kohl-Himmelseher, Matthias

2012-11-01

The decision criterion for the demarcation between foods and medicinal products in the EU is the significant "pharmacological action". Based on six examples of substances with ambivalent status, the benchmark dose (BMD) method is evaluated to provide a threshold for pharmacological action. Using significant dose-response models from literature clinical trial data or epidemiology, the BMD values were 63mg/day for caffeine, 5g/day for alcohol, 6mg/day for lovastatin, 769mg/day for glucosamine sulfate, 151mg/day for Ginkgo biloba extract, and 0.4mg/day for melatonin. The examples for caffeine and alcohol validate the approach because intake above BMD clearly exhibits pharmacological action. Nevertheless, due to uncertainties in dose-response modelling as well as the need for additional uncertainty factors to consider differences in sensitivity within the human population, a "borderline range" on the dose-response curve remains. "Pharmacological action" has proven to be not very well suited as binary decision criterion between foods and medicinal product. The European legislator should rethink the definition of medicinal products, as the current situation based on complicated case-by-case decisions on pharmacological action leads to an unregulated market flooded with potentially illegal food supplements. Copyright © 2012 Elsevier Inc. All rights reserved.

Verification and validation benchmarks

International Nuclear Information System (INIS)

Oberkampf, William Louis; Trucano, Timothy Guy

2007-01-01

Verification and validation (V and V) are the primary means to assess the accuracy and reliability of computational simulations. V and V methods and procedures have fundamentally improved the credibility of simulations in several high-consequence fields, such as nuclear reactor safety, underground nuclear waste storage, and nuclear weapon safety. Although the terminology is not uniform across engineering disciplines, code verification deals with assessing the reliability of the software coding, and solution verification deals with assessing the numerical accuracy of the solution to a computational model. Validation addresses the physics modeling accuracy of a computational simulation by comparing the computational results with experimental data. Code verification benchmarks and validation benchmarks have been constructed for a number of years in every field of computational simulation. However, no comprehensive guidelines have been proposed for the construction and use of V and V benchmarks. For example, the field of nuclear reactor safety has not focused on code verification benchmarks, but it has placed great emphasis on developing validation benchmarks. Many of these validation benchmarks are closely related to the operations of actual reactors at near-safety-critical conditions, as opposed to being more fundamental-physics benchmarks. This paper presents recommendations for the effective design and use of code verification benchmarks based on manufactured solutions, classical analytical solutions, and highly accurate numerical solutions. In addition, this paper presents recommendations for the design and use of validation benchmarks, highlighting the careful design of building-block experiments, the estimation of experimental measurement uncertainty for both inputs and outputs to the code, validation metrics, and the role of model calibration in validation. It is argued that the understanding of predictive capability of a computational model is built on the

Verification and validation benchmarks

International Nuclear Information System (INIS)

Oberkampf, William L.; Trucano, Timothy G.

2008-01-01

Verification and validation (V and V) are the primary means to assess the accuracy and reliability of computational simulations. V and V methods and procedures have fundamentally improved the credibility of simulations in several high-consequence fields, such as nuclear reactor safety, underground nuclear waste storage, and nuclear weapon safety. Although the terminology is not uniform across engineering disciplines, code verification deals with assessing the reliability of the software coding, and solution verification deals with assessing the numerical accuracy of the solution to a computational model. Validation addresses the physics modeling accuracy of a computational simulation by comparing the computational results with experimental data. Code verification benchmarks and validation benchmarks have been constructed for a number of years in every field of computational simulation. However, no comprehensive guidelines have been proposed for the construction and use of V and V benchmarks. For example, the field of nuclear reactor safety has not focused on code verification benchmarks, but it has placed great emphasis on developing validation benchmarks. Many of these validation benchmarks are closely related to the operations of actual reactors at near-safety-critical conditions, as opposed to being more fundamental-physics benchmarks. This paper presents recommendations for the effective design and use of code verification benchmarks based on manufactured solutions, classical analytical solutions, and highly accurate numerical solutions. In addition, this paper presents recommendations for the design and use of validation benchmarks, highlighting the careful design of building-block experiments, the estimation of experimental measurement uncertainty for both inputs and outputs to the code, validation metrics, and the role of model calibration in validation. It is argued that the understanding of predictive capability of a computational model is built on the

The Data Envelopment Analysis Method in Benchmarking of Technological Incubators

Directory of Open Access Journals (Sweden)

Bożena Kaczmarska

2010-01-01

Full Text Available This paper presents an original concept for the application of Data Envelopment Analysis (DEA in benchmarking processes within innovation and entrepreneurship centers based on the example of technological incubators. Applying the DEA method, it is possible to order analyzed objects, on the basis of explicitly defined relative efficiency, by compiling a rating list and rating classes. Establishing standards and indicating “clearances” allows the studied objects - innovation and entrepreneurship centers - to select a way of developing effectively, as well as preserving their individuality and a unique way of acting with the account of local needs. (original abstract

Benchmarking the energy efficiency of commercial buildings

International Nuclear Information System (INIS)

Chung, William; Hui, Y.V.; Lam, Y. Miu

2006-01-01

Benchmarking energy-efficiency is an important tool to promote the efficient use of energy in commercial buildings. Benchmarking models are mostly constructed in a simple benchmark table (percentile table) of energy use, which is normalized with floor area and temperature. This paper describes a benchmarking process for energy efficiency by means of multiple regression analysis, where the relationship between energy-use intensities (EUIs) and the explanatory factors (e.g., operating hours) is developed. Using the resulting regression model, these EUIs are then normalized by removing the effect of deviance in the significant explanatory factors. The empirical cumulative distribution of the normalized EUI gives a benchmark table (or percentile table of EUI) for benchmarking an observed EUI. The advantage of this approach is that the benchmark table represents a normalized distribution of EUI, taking into account all the significant explanatory factors that affect energy consumption. An application to supermarkets is presented to illustrate the development and the use of the benchmarking method

Impact of quantitative feedback and benchmark selection on radiation use by cardiologists performing cardiac angiography

International Nuclear Information System (INIS)

Smith, I. R.; Cameron, J.; Brighouse, R. D.; Ryan, C. M.; Foster, K. A.; Rivers, J. T.

2013-01-01

Audit of and feedback on both group and individual data provided immediately after the point of care and compared with realistic benchmarks of excellence have been demonstrated to drive change. This study sought to evaluate the impact of immediate benchmarked quantitative case-based performance feedback on the clinical practice of cardiologists practicing at a private hospital in Brisbane, Australia. The participating cardiologists were assigned to one of two groups: Group 1 received patient and procedural details for review and Group 2 received Group 1 data plus detailed radiation data relating to the procedures and comparative benchmarks. In Group 2, Linear-by-Linear Association analysis suggests a link between change in radiation use and initial radiation dose category (p50.014) with only those initially 'challenged' by the benchmarks showing improvement. Those not 'challenged' by the benchmarks deteriorated in performance compared with those starting well below the benchmarks showing greatest increase in radiation use. Conversely, those blinded to their radiation use (Group 1) showed general improvement in radiation use throughout the study compared with those performing initially close to the benchmarks showing greatest improvement. This study shows that use of non-challenging benchmarks in case-based radiation risk feedback does not promote a reduction in radiation use; indeed, it may contribute to increased doses. Paradoxically, cardiologists who are aware of performance monitoring but blinded to individual case data appear to maintain, if not reduce, their radiation use. (authors)

Benchmarking in digital circuit design automation

NARCIS (Netherlands)

Jozwiak, L.; Gawlowski, D.M.; Slusarczyk, A.S.

2008-01-01

This paper focuses on benchmarking, which is the main experimental approach to the design method and EDA-tool analysis, characterization and evaluation. We discuss the importance and difficulties of benchmarking, as well as the recent research effort related to it. To resolve several serious

Benchmarking, Total Quality Management, and Libraries.

Science.gov (United States)

Shaughnessy, Thomas W.

1993-01-01

Discussion of the use of Total Quality Management (TQM) in higher education and academic libraries focuses on the identification, collection, and use of reliable data. Methods for measuring quality, including benchmarking, are described; performance measures are considered; and benchmarking techniques are examined. (11 references) (MES)

A Heterogeneous Medium Analytical Benchmark

International Nuclear Information System (INIS)

Ganapol, B.D.

1999-01-01

A benchmark, called benchmark BLUE, has been developed for one-group neutral particle (neutron or photon) transport in a one-dimensional sub-critical heterogeneous plane parallel medium with surface illumination. General anisotropic scattering is accommodated through the Green's Function Method (GFM). Numerical Fourier transform inversion is used to generate the required Green's functions which are kernels to coupled integral equations that give the exiting angular fluxes. The interior scalar flux is then obtained through quadrature. A compound iterative procedure for quadrature order and slab surface source convergence provides highly accurate benchmark qualities (4- to 5- places of accuracy) results

Self-benchmarking Guide for Cleanrooms: Metrics, Benchmarks, Actions

Energy Technology Data Exchange (ETDEWEB)

Mathew, Paul; Sartor, Dale; Tschudi, William

2009-07-13

This guide describes energy efficiency metrics and benchmarks that can be used to track the performance of and identify potential opportunities to reduce energy use in laboratory buildings. This guide is primarily intended for personnel who have responsibility for managing energy use in existing laboratory facilities - including facilities managers, energy managers, and their engineering consultants. Additionally, laboratory planners and designers may also use the metrics and benchmarks described in this guide for goal-setting in new construction or major renovation. This guide provides the following information: (1) A step-by-step outline of the benchmarking process. (2) A set of performance metrics for the whole building as well as individual systems. For each metric, the guide provides a definition, performance benchmarks, and potential actions that can be inferred from evaluating this metric. (3) A list and descriptions of the data required for computing the metrics. This guide is complemented by spreadsheet templates for data collection and for computing the benchmarking metrics. This guide builds on prior research supported by the national Laboratories for the 21st Century (Labs21) program, supported by the U.S. Department of Energy and the U.S. Environmental Protection Agency. Much of the benchmarking data are drawn from the Labs21 benchmarking database and technical guides. Additional benchmark data were obtained from engineering experts including laboratory designers and energy managers.

ICSBEP-2007, International Criticality Safety Benchmark Experiment Handbook

International Nuclear Information System (INIS)

Blair Briggs, J.

2007-01-01

1 - Description: The Critically Safety Benchmark Evaluation Project (CSBEP) was initiated in October of 1992 by the United Sates Department of Energy. The project quickly became an international effort as scientist from other interested countries became involved. The International Criticality Safety Benchmark Evaluation Project (ICSBEP) is now an official activity of the Organization of Economic Cooperation and Development - Nuclear Energy Agency (OECD-NEA). This handbook contains criticality safety benchmark specifications that have been derived from experiments that were performed at various nuclear critical facilities around the world. The benchmark specifications are intended for use by criticality safety engineers to validate calculational techniques used to establish minimum subcritical margins for operations with fissile material. The example calculations presented do not constitute a validation of the codes or cross section data. The work of the ICSBEP is documented as an International Handbook of Evaluated Criticality Safety Benchmark Experiments. Currently, the handbook spans over 42,000 pages and contains 464 evaluations representing 4,092 critical, near-critical, or subcritical configurations and 21 criticality alarm placement/shielding configurations with multiple dose points for each and 46 configurations that have been categorized as fundamental physics measurements that are relevant to criticality safety applications. The handbook is intended for use by criticality safety analysts to perform necessary validations of their calculational techniques and is expected to be a valuable tool for decades to come. The ICSBEP Handbook is available on DVD. You may request a DVD by completing the DVD Request Form on the internet. Access to the Handbook on the Internet requires a password. You may request a password by completing the Password Request Form. The Web address is: http://icsbep.inel.gov/handbook.shtml 2 - Method of solution: Experiments that are found

Track benchmarking method for uncertainty quantification of particle tracking velocimetry interpolations

International Nuclear Information System (INIS)

Schneiders, Jan F G; Sciacchitano, Andrea

2017-01-01

The track benchmarking method (TBM) is proposed for uncertainty quantification of particle tracking velocimetry (PTV) data mapped onto a regular grid. The method provides statistical uncertainty for a velocity time-series and can in addition be used to obtain instantaneous uncertainty at increased computational cost. Interpolation techniques are typically used to map velocity data from scattered PTV (e.g. tomographic PTV and Shake-the-Box) measurements onto a Cartesian grid. Recent examples of these techniques are the FlowFit and VIC+  methods. The TBM approach estimates the random uncertainty in dense velocity fields by performing the velocity interpolation using a subset of typically 95% of the particle tracks and by considering the remaining tracks as an independent benchmarking reference. In addition, also a bias introduced by the interpolation technique is identified. The numerical assessment shows that the approach is accurate when particle trajectories are measured over an extended number of snapshots, typically on the order of 10. When only short particle tracks are available, the TBM estimate overestimates the measurement error. A correction to TBM is proposed and assessed to compensate for this overestimation. The experimental assessment considers the case of a jet flow, processed both by tomographic PIV and by VIC+. The uncertainty obtained by TBM provides a quantitative evaluation of the measurement accuracy and precision and highlights the regions of high error by means of bias and random uncertainty maps. In this way, it is possible to quantify the uncertainty reduction achieved by advanced interpolation algorithms with respect to standard correlation-based tomographic PIV. The use of TBM for uncertainty quantification and comparison of different processing techniques is demonstrated. (paper)

A track length estimator method for dose calculations in low-energy X-ray irradiations. Implementation, properties and performance

Energy Technology Data Exchange (ETDEWEB)

Baldacci, F.; Delaire, F.; Letang, J.M.; Sarrut, D.; Smekens, F.; Freud, N. [Lyon-1 Univ. - CREATIS, CNRS UMR5220, Inserm U1044, INSA-Lyon, Centre Leon Berard (France); Mittone, A.; Coan, P. [LMU Munich (Germany). Dept. of Physics; LMU Munich (Germany). Faculty of Medicine; Bravin, A.; Ferrero, C. [European Synchrotron Radiation Facility, Grenoble (France); Gasilov, S. [LMU Munich (Germany). Dept. of Physics

2015-05-01

The track length estimator (TLE) method, an 'on-the-fly' fluence tally in Monte Carlo (MC) simulations, recently implemented in GATE 6.2, is known as a powerful tool to accelerate dose calculations in the domain of low-energy X-ray irradiations using the kerma approximation. Overall efficiency gains of the TLE with respect to analogous MC were reported in the literature for regions of interest in various applications (photon beam radiation therapy, X-ray imaging). The behaviour of the TLE method in terms of statistical properties, dose deposition patterns, and computational efficiency compared to analogous MC simulations was investigated. The statistical properties of the dose deposition were first assessed. Derivations of the variance reduction factor of TLE versus analogous MC were carried out, starting from the expression of the dose estimate variance in the TLE and analogous MC schemes. Two test cases were chosen to benchmark the TLE performance in comparison with analogous MC: (i) a small animal irradiation under stereotactic synchrotron radiation therapy conditions and (ii) the irradiation of a human pelvis during a cone beam computed tomography acquisition. Dose distribution patterns and efficiency gain maps were analysed. The efficiency gain exhibits strong variations within a given irradiation case, depending on the geometrical (voxel size, ballistics) and physical (material and beam properties) parameters on the voxel scale. Typical values lie between 10 and 103, with lower levels in dense regions (bone) outside the irradiated channels (scattered dose only), and higher levels in soft tissues directly exposed to the beams.

Evaluation of piping fracture analysis method by benchmark study, 1

International Nuclear Information System (INIS)

Takahashi, Yukio; Kashima, Koichi; Kuwabara, Kazuo

1987-01-01

Importance of strength evaluation methods for cracked piping is growing with the progress of the rationalization of the nuclear piping system based on the leak-before-break concept. As an analytical tool, finite element method is principally used. To obtain the reliable solutions by the finite element programs, it is important to grasp the influences of various factors on the solutions. In this study, benchmark analysis is carried out for a stainless steel pipe with a circumferential through-wall crack subjected to four-point bending loading. Eight solutions obtained by using five finite element programs are compared with each other. Good agreement is obtained between the solutions on the deformation characteristics as well as fracture mechanics parameters. It is found through this study that the influence of the difference in the solution technique is generally small. (author)

Derivation of the critical effect size/benchmark response for the dose-response analysis of the uptake of radioactive iodine in the human thyroid.

Science.gov (United States)

Weterings, Peter J J M; Loftus, Christine; Lewandowski, Thomas A

2016-08-22

Potential adverse effects of chemical substances on thyroid function are usually examined by measuring serum levels of thyroid-related hormones. Instead, recent risk assessments for thyroid-active chemicals have focussed on iodine uptake inhibition, an upstream event that by itself is not necessarily adverse. Establishing the extent of uptake inhibition that can be considered de minimis, the chosen benchmark response (BMR), is therefore critical. The BMR values selected by two international advisory bodies were 5% and 50%, a difference that had correspondingly large impacts on the estimated risks and health-based guidance values that were established. Potential treatment-related inhibition of thyroidal iodine uptake is usually determined by comparing thyroidal uptake of radioactive iodine (RAIU) during treatment with a single pre-treatment RAIU value. In the present study it is demonstrated that the physiological intra-individual variation in iodine uptake is much larger than 5%. Consequently, in-treatment RAIU values, expressed as a percentage of the pre-treatment value, have an inherent variation, that needs to be considered when conducting dose-response analyses. Based on statistical and biological considerations, a BMR of 20% is proposed for benchmark dose analysis of human thyroidal iodine uptake data, to take the inherent variation in relative RAIU data into account. Implications for the tolerated daily intakes for perchlorate and chlorate, recently established by the European Food Safety Authority (EFSA), are discussed. Copyright © 2016 The Author(s). Published by Elsevier Ireland Ltd.. All rights reserved.

IAEA sodium void reactivity benchmark calculations

International Nuclear Information System (INIS)

Hill, R.N.; Finck, P.J.

1992-01-01

In this paper, the IAEA-1 992 ''Benchmark Calculation of Sodium Void Reactivity Effect in Fast Reactor Core'' problem is evaluated. The proposed design is a large axially heterogeneous oxide-fueled fast reactor as described in Section 2; the core utilizes a sodium plenum above the core to enhance leakage effects. The calculation methods used in this benchmark evaluation are described in Section 3. In Section 4, the calculated core performance results for the benchmark reactor model are presented; and in Section 5, the influence of steel and interstitial sodium heterogeneity effects is estimated

SU-E-J-30: Benchmark Image-Based TCP Calculation for Evaluation of PTV Margins for Lung SBRT Patients

Energy Technology Data Exchange (ETDEWEB)

Li, M [Wayne State Univeristy, Detroit, MI (United States); Chetty, I [Henry Ford Health System, Detroit, MI (United States); Zhong, H [Henry Ford Hospital System, Detroit, MI (United States)

2014-06-01

Purpose: Tumor control probability (TCP) calculated with accumulated radiation doses may help design appropriate treatment margins. Image registration errors, however, may compromise the calculated TCP. The purpose of this study is to develop benchmark CT images to quantify registration-induced errors in the accumulated doses and their corresponding TCP. Methods: 4DCT images were registered from end-inhale (EI) to end-exhale (EE) using a “demons” algorithm. The demons DVFs were corrected by an FEM model to get realistic deformation fields. The FEM DVFs were used to warp the EI images to create the FEM-simulated images. The two images combined with the FEM DVF formed a benchmark model. Maximum intensity projection (MIP) images, created from the EI and simulated images, were used to develop IMRT plans. Two plans with 3 and 5 mm margins were developed for each patient. With these plans, radiation doses were recalculated on the simulated images and warped back to the EI images using the FEM DVFs to get the accumulated doses. The Elastix software was used to register the FEM-simulated images to the EI images. TCPs calculated with the Elastix-accumulated doses were compared with those generated by the FEM to get the TCP error of the Elastix registrations. Results: For six lung patients, the mean Elastix registration error ranged from 0.93 to 1.98 mm. Their relative dose errors in PTV were between 0.28% and 6.8% for 3mm margin plans, and between 0.29% and 6.3% for 5mm-margin plans. As the PTV margin reduced from 5 to 3 mm, the mean TCP error of the Elastix-reconstructed doses increased from 2.0% to 2.9%, and the mean NTCP errors decreased from 1.2% to 1.1%. Conclusion: Patient-specific benchmark images can be used to evaluate the impact of registration errors on the computed TCPs, and may help select appropriate PTV margins for lung SBRT patients.

SU-E-J-30: Benchmark Image-Based TCP Calculation for Evaluation of PTV Margins for Lung SBRT Patients

International Nuclear Information System (INIS)

Li, M; Chetty, I; Zhong, H

2014-01-01

Purpose: Tumor control probability (TCP) calculated with accumulated radiation doses may help design appropriate treatment margins. Image registration errors, however, may compromise the calculated TCP. The purpose of this study is to develop benchmark CT images to quantify registration-induced errors in the accumulated doses and their corresponding TCP. Methods: 4DCT images were registered from end-inhale (EI) to end-exhale (EE) using a “demons” algorithm. The demons DVFs were corrected by an FEM model to get realistic deformation fields. The FEM DVFs were used to warp the EI images to create the FEM-simulated images. The two images combined with the FEM DVF formed a benchmark model. Maximum intensity projection (MIP) images, created from the EI and simulated images, were used to develop IMRT plans. Two plans with 3 and 5 mm margins were developed for each patient. With these plans, radiation doses were recalculated on the simulated images and warped back to the EI images using the FEM DVFs to get the accumulated doses. The Elastix software was used to register the FEM-simulated images to the EI images. TCPs calculated with the Elastix-accumulated doses were compared with those generated by the FEM to get the TCP error of the Elastix registrations. Results: For six lung patients, the mean Elastix registration error ranged from 0.93 to 1.98 mm. Their relative dose errors in PTV were between 0.28% and 6.8% for 3mm margin plans, and between 0.29% and 6.3% for 5mm-margin plans. As the PTV margin reduced from 5 to 3 mm, the mean TCP error of the Elastix-reconstructed doses increased from 2.0% to 2.9%, and the mean NTCP errors decreased from 1.2% to 1.1%. Conclusion: Patient-specific benchmark images can be used to evaluate the impact of registration errors on the computed TCPs, and may help select appropriate PTV margins for lung SBRT patients

Benchmark Credentialing Results for NRG-BR001: The First National Cancer Institute-Sponsored Trial of Stereotactic Body Radiation Therapy for Multiple Metastases

Energy Technology Data Exchange (ETDEWEB)

Al-Hallaq, Hania A., E-mail: halhallaq@radonc.uchicago.edu [Department of Radiation and Cellular Oncology, Chicago, Illinois (United States); Chmura, Steven J. [Department of Radiation and Cellular Oncology, Chicago, Illinois (United States); Salama, Joseph K. [Department of Radiation Oncology, Durham, North Carolina (United States); Lowenstein, Jessica R. [Imaging and Radiation Oncology Core Group (IROC) Houston, MD Anderson Cancer Center, Houston, Texas (United States); McNulty, Susan; Galvin, James M. [Imaging and Radiation Oncology Core Group (IROC) PHILADELPHIA RT, Philadelphia, Pennsylvania (United States); Followill, David S. [Imaging and Radiation Oncology Core Group (IROC) Houston, MD Anderson Cancer Center, Houston, Texas (United States); Robinson, Clifford G. [Department of Radiation Oncology, St Louis, Missouri (United States); Pisansky, Thomas M. [Department of Radiation Oncology, Rochester, Minnesota (United States); Winter, Kathryn A. [NRG Oncology Statistics and Data Management Center, Philadelphia, Pennsylvania (United States); White, Julia R. [Department of Radiation Oncology, Columbus, Ohio (United States); Xiao, Ying [Imaging and Radiation Oncology Core Group (IROC) PHILADELPHIA RT, Philadelphia, Pennsylvania (United States); Department of Radiation Oncology, Philadelphia, Pennsylvania (United States); Matuszak, Martha M. [Department of Radiation Oncology, Ann Arbor, Michigan (United States)

2017-01-01

Purpose: The NRG-BR001 trial is the first National Cancer Institute–sponsored trial to treat multiple (range 2-4) extracranial metastases with stereotactic body radiation therapy. Benchmark credentialing is required to ensure adherence to this complex protocol, in particular, for metastases in close proximity. The present report summarizes the dosimetric results and approval rates. Methods and Materials: The benchmark used anonymized data from a patient with bilateral adrenal metastases, separated by <5 cm of normal tissue. Because the planning target volume (PTV) overlaps with organs at risk (OARs), institutions must use the planning priority guidelines to balance PTV coverage (45 Gy in 3 fractions) against OAR sparing. Submitted plans were processed by the Imaging and Radiation Oncology Core and assessed by the protocol co-chairs by comparing the doses to targets, OARs, and conformity metrics using nonparametric tests. Results: Of 63 benchmarks submitted through October 2015, 94% were approved, with 51% approved at the first attempt. Most used volumetric arc therapy (VMAT) (78%), a single plan for both PTVs (90%), and prioritized the PTV over the stomach (75%). The median dose to 95% of the volume was 44.8 ± 1.0 Gy and 44.9 ± 1.0 Gy for the right and left PTV, respectively. The median dose to 0.03 cm{sup 3} was 14.2 ± 2.2 Gy to the spinal cord and 46.5 ± 3.1 Gy to the stomach. Plans that spared the stomach significantly reduced the dose to the left PTV and stomach. Conformity metrics were significantly better for single plans that simultaneously treated both PTVs with VMAT, intensity modulated radiation therapy, or 3-dimensional conformal radiation therapy compared with separate plans. No significant differences existed in the dose at 2 cm from the PTVs. Conclusions: Although most plans used VMAT, the range of conformity and dose falloff was large. The decision to prioritize either OARs or PTV coverage varied considerably, suggesting that

Self-benchmarking Guide for Laboratory Buildings: Metrics, Benchmarks, Actions

Energy Technology Data Exchange (ETDEWEB)

Mathew, Paul; Greenberg, Steve; Sartor, Dale

2009-07-13

This guide describes energy efficiency metrics and benchmarks that can be used to track the performance of and identify potential opportunities to reduce energy use in laboratory buildings. This guide is primarily intended for personnel who have responsibility for managing energy use in existing laboratory facilities - including facilities managers, energy managers, and their engineering consultants. Additionally, laboratory planners and designers may also use the metrics and benchmarks described in this guide for goal-setting in new construction or major renovation. This guide provides the following information: (1) A step-by-step outline of the benchmarking process. (2) A set of performance metrics for the whole building as well as individual systems. For each metric, the guide provides a definition, performance benchmarks, and potential actions that can be inferred from evaluating this metric. (3) A list and descriptions of the data required for computing the metrics. This guide is complemented by spreadsheet templates for data collection and for computing the benchmarking metrics. This guide builds on prior research supported by the national Laboratories for the 21st Century (Labs21) program, supported by the U.S. Department of Energy and the U.S. Environmental Protection Agency. Much of the benchmarking data are drawn from the Labs21 benchmarking database and technical guides. Additional benchmark data were obtained from engineering experts including laboratory designers and energy managers.

H.B. Robinson-2 pressure vessel benchmark

Energy Technology Data Exchange (ETDEWEB)

Remec, I.; Kam, F.B.K.

1998-02-01

The H. B. Robinson Unit 2 Pressure Vessel Benchmark (HBR-2 benchmark) is described and analyzed in this report. Analysis of the HBR-2 benchmark can be used as partial fulfillment of the requirements for the qualification of the methodology for calculating neutron fluence in pressure vessels, as required by the U.S. Nuclear Regulatory Commission Regulatory Guide DG-1053, Calculational and Dosimetry Methods for Determining Pressure Vessel Neutron Fluence. Section 1 of this report describes the HBR-2 benchmark and provides all the dimensions, material compositions, and neutron source data necessary for the analysis. The measured quantities, to be compared with the calculated values, are the specific activities at the end of fuel cycle 9. The characteristic feature of the HBR-2 benchmark is that it provides measurements on both sides of the pressure vessel: in the surveillance capsule attached to the thermal shield and in the reactor cavity. In section 2, the analysis of the HBR-2 benchmark is described. Calculations with the computer code DORT, based on the discrete-ordinates method, were performed with three multigroup libraries based on ENDF/B-VI: BUGLE-93, SAILOR-95 and BUGLE-96. The average ratio of the calculated-to-measured specific activities (C/M) for the six dosimeters in the surveillance capsule was 0.90 {+-} 0.04 for all three libraries. The average C/Ms for the cavity dosimeters (without neptunium dosimeter) were 0.89 {+-} 0.10, 0.91 {+-} 0.10, and 0.90 {+-} 0.09 for the BUGLE-93, SAILOR-95 and BUGLE-96 libraries, respectively. It is expected that the agreement of the calculations with the measurements, similar to the agreement obtained in this research, should typically be observed when the discrete-ordinates method and ENDF/B-VI libraries are used for the HBR-2 benchmark analysis.

Benchmarking to improve the quality of cystic fibrosis care.

Science.gov (United States)

Schechter, Michael S

2012-11-01

Benchmarking involves the ascertainment of healthcare programs with most favorable outcomes as a means to identify and spread effective strategies for delivery of care. The recent interest in the development of patient registries for patients with cystic fibrosis (CF) has been fueled in part by an interest in using them to facilitate benchmarking. This review summarizes reports of how benchmarking has been operationalized in attempts to improve CF care. Although certain goals of benchmarking can be accomplished with an exclusive focus on registry data analysis, benchmarking programs in Germany and the United States have supplemented these data analyses with exploratory interactions and discussions to better understand successful approaches to care and encourage their spread throughout the care network. Benchmarking allows the discovery and facilitates the spread of effective approaches to care. It provides a pragmatic alternative to traditional research methods such as randomized controlled trials, providing insights into methods that optimize delivery of care and allowing judgments about the relative effectiveness of different therapeutic approaches.

Consortial Benchmarking: a method of academic-practitioner collaborative research and its application in a B2B environment

NARCIS (Netherlands)

Schiele, Holger; Krummaker, Stefan

2010-01-01

Purpose of the paper and literature addressed: Development of a new method for academicpractitioner collaboration, addressing the literature on collaborative research Research method: Model elaboration and test with an in-depth case study Research findings: In consortial benchmarking, practitioners

Quality management benchmarking: FDA compliance in pharmaceutical industry.

Science.gov (United States)

Jochem, Roland; Landgraf, Katja

2010-01-01

By analyzing and comparing industry and business best practice, processes can be optimized and become more successful mainly because efficiency and competitiveness increase. This paper aims to focus on some examples. Case studies are used to show knowledge exchange in the pharmaceutical industry. Best practice solutions were identified in two companies using a benchmarking method and five-stage model. Despite large administrations, there is much potential regarding business process organization. This project makes it possible for participants to fully understand their business processes. The benchmarking method gives an opportunity to critically analyze value chains (a string of companies or players working together to satisfy market demands for a special product). Knowledge exchange is interesting for companies that like to be global players. Benchmarking supports information exchange and improves competitive ability between different enterprises. Findings suggest that the five-stage model improves efficiency and effectiveness. Furthermore, the model increases the chances for reaching targets. The method gives security to partners that did not have benchmarking experience. The study identifies new quality management procedures. Process management and especially benchmarking is shown to support pharmaceutical industry improvements.

Bacterial whole genome-based phylogeny: construction of a new benchmarking dataset and assessment of some existing methods

DEFF Research Database (Denmark)

Ahrenfeldt, Johanne; Skaarup, Carina; Hasman, Henrik

2017-01-01

from sequencing reads. In the present study we describe a new dataset that we have created for the purpose of benchmarking such WGS-based methods for epidemiological data, and also present an analysis where we use the data to compare the performance of some current methods. Results Our aim...

Benchmarking Dosimetric Quality Assessment of Prostate Intensity-Modulated Radiotherapy

International Nuclear Information System (INIS)

Senthi, Sashendra; Gill, Suki S.; Haworth, Annette; Kron, Tomas; Cramb, Jim; Rolfo, Aldo; Thomas, Jessica; Duchesne, Gillian M.; Hamilton, Christopher H.; Joon, Daryl Lim; Bowden, Patrick; Foroudi, Farshad

2012-01-01

Purpose: To benchmark the dosimetric quality assessment of prostate intensity-modulated radiotherapy and determine whether the quality is influenced by disease or treatment factors. Patients and Methods: We retrospectively analyzed the data from 155 consecutive men treated radically for prostate cancer using intensity-modulated radiotherapy to 78 Gy between January 2007 and March 2009 across six radiotherapy treatment centers. The plan quality was determined by the measures of coverage, homogeneity, and conformity. Tumor coverage was measured using the planning target volume (PTV) receiving 95% and 100% of the prescribed dose (V 95% and V 100% , respectively) and the clinical target volume (CTV) receiving 95% and 100% of the prescribed dose. Homogeneity was measured using the sigma index of the PTV and CTV. Conformity was measured using the lesion coverage factor, healthy tissue conformity index, and the conformity number. Multivariate regression models were created to determine the relationship between these and T stage, risk status, androgen deprivation therapy use, treatment center, planning system, and treatment date. Results: The largest discriminatory measurements of coverage, homogeneity, and conformity were the PTV V 95% , PTV sigma index, and conformity number. The mean PTV V 95% was 92.5% (95% confidence interval, 91.3–93.7%). The mean PTV sigma index was 2.10 Gy (95% confidence interval, 1.90–2.20). The mean conformity number was 0.78 (95% confidence interval, 0.76–0.79). The treatment center independently influenced the coverage, homogeneity, and conformity (all p 95% only, with it being better at the start (p = .013). Risk status, T stage, and the use of androgen deprivation therapy did not influence any aspect of plan quality. Conclusion: Our study has benchmarked measures of coverage, homogeneity, and conformity for the treatment of prostate cancer using IMRT. The differences seen between centers and planning systems and the coverage

MIPS bacterial genomes functional annotation benchmark dataset.

Science.gov (United States)

Tetko, Igor V; Brauner, Barbara; Dunger-Kaltenbach, Irmtraud; Frishman, Goar; Montrone, Corinna; Fobo, Gisela; Ruepp, Andreas; Antonov, Alexey V; Surmeli, Dimitrij; Mewes, Hans-Wernen

2005-05-15

Any development of new methods for automatic functional annotation of proteins according to their sequences requires high-quality data (as benchmark) as well as tedious preparatory work to generate sequence parameters required as input data for the machine learning methods. Different program settings and incompatible protocols make a comparison of the analyzed methods difficult. The MIPS Bacterial Functional Annotation Benchmark dataset (MIPS-BFAB) is a new, high-quality resource comprising four bacterial genomes manually annotated according to the MIPS functional catalogue (FunCat). These resources include precalculated sequence parameters, such as sequence similarity scores, InterPro domain composition and other parameters that could be used to develop and benchmark methods for functional annotation of bacterial protein sequences. These data are provided in XML format and can be used by scientists who are not necessarily experts in genome annotation. BFAB is available at http://mips.gsf.de/proj/bfab

Ad hoc committee on reactor physics benchmarks

International Nuclear Information System (INIS)

Diamond, D.J.; Mosteller, R.D.; Gehin, J.C.

1996-01-01

In the spring of 1994, an ad hoc committee on reactor physics benchmarks was formed under the leadership of two American Nuclear Society (ANS) organizations. The ANS-19 Standards Subcommittee of the Reactor Physics Division and the Computational Benchmark Problem Committee of the Mathematics and Computation Division had both seen a need for additional benchmarks to help validate computer codes used for light water reactor (LWR) neutronics calculations. Although individual organizations had employed various means to validate the reactor physics methods that they used for fuel management, operations, and safety, additional work in code development and refinement is under way, and to increase accuracy, there is a need for a corresponding increase in validation. Both organizations thought that there was a need to promulgate benchmarks based on measured data to supplement the LWR computational benchmarks that have been published in the past. By having an organized benchmark activity, the participants also gain by being able to discuss their problems and achievements with others traveling the same route

Benchmarking for Cost Improvement. Final report

Energy Technology Data Exchange (ETDEWEB)

1993-09-01

The US Department of Energy`s (DOE) Office of Environmental Restoration and Waste Management (EM) conducted the Benchmarking for Cost Improvement initiative with three objectives: Pilot test benchmarking as an EM cost improvement tool; identify areas for cost improvement and recommend actions to address these areas; provide a framework for future cost improvement. The benchmarking initiative featured the use of four principal methods (program classification, nationwide cost improvement survey, paired cost comparison and component benchmarking). Interested parties contributed during both the design and execution phases. The benchmarking initiative was conducted on an accelerated basis. Of necessity, it considered only a limited set of data that may not be fully representative of the diverse and complex conditions found at the many DOE installations. The initiative generated preliminary data about cost differences and it found a high degree of convergence on several issues. Based on this convergence, the report recommends cost improvement strategies and actions. This report describes the steps taken as part of the benchmarking initiative and discusses the findings and recommended actions for achieving cost improvement. The results and summary recommendations, reported below, are organized by the study objectives.

Benchmarking von Krankenhausinformationssystemen – eine vergleichende Analyse deutschsprachiger Benchmarkingcluster

Directory of Open Access Journals (Sweden)

Jahn, Franziska

2015-08-01

Full Text Available Benchmarking is a method of strategic information management used by many hospitals today. During the last years, several benchmarking clusters have been established within the German-speaking countries. They support hospitals in comparing and positioning their information system’s and information management’s costs, performance and efficiency against other hospitals. In order to differentiate between these benchmarking clusters and to provide decision support in selecting an appropriate benchmarking cluster, a classification scheme is developed. The classification scheme observes both general conditions and examined contents of the benchmarking clusters. It is applied to seven benchmarking clusters which have been active in the German-speaking countries within the last years. Currently, performance benchmarking is the most frequent benchmarking type, whereas the observed benchmarking clusters differ in the number of benchmarking partners and their cooperation forms. The benchmarking clusters also deal with different benchmarking subjects. Assessing costs and quality application systems, physical data processing systems, organizational structures of information management and IT services processes are the most frequent benchmarking subjects. There is still potential for further activities within the benchmarking clusters to measure strategic and tactical information management, IT governance and quality of data and data-processing processes. Based on the classification scheme and the comparison of the benchmarking clusters, we derive general recommendations for benchmarking of hospital information systems.

Evaluating the Resilience of the Bottom-up Method used to Detect and Benchmark the Smartness of University Campuses

NARCIS (Netherlands)

Giovannella, Carlo; Andone, Diana; Dascalu, Mihai; Popescu, Elvira; Rehm, Matthias; Mealha, Oscar

2017-01-01

A new method to perform a bottom-up extraction and benchmark of the perceived multilevel smartness of complex ecosystems has been recently described and applied to territories and learning ecosystems like university campuses and schools. In this paper we study the resilience of our method

Regression Benchmarking: An Approach to Quality Assurance in Performance

OpenAIRE

Bulej, Lubomír

2005-01-01

The paper presents a short summary of our work in the area of regression benchmarking and its application to software development. Specially, we explain the concept of regression benchmarking, the requirements for employing regression testing in a software project, and methods used for analyzing the vast amounts of data resulting from repeated benchmarking. We present the application of regression benchmarking on a real software project and conclude with a glimpse at the challenges for the fu...

Predicting standard-dose PET image from low-dose PET and multimodal MR images using mapping-based sparse representation

International Nuclear Information System (INIS)

Wang, Yan; Zhou, Jiliu; Zhang, Pei; An, Le; Ma, Guangkai; Kang, Jiayin; Shi, Feng; Shen, Dinggang; Wu, Xi; Lalush, David S; Lin, Weili

2016-01-01

Positron emission tomography (PET) has been widely used in clinical diagnosis for diseases and disorders. To obtain high-quality PET images requires a standard-dose radionuclide (tracer) injection into the human body, which inevitably increases risk of radiation exposure. One possible solution to this problem is to predict the standard-dose PET image from its low-dose counterpart and its corresponding multimodal magnetic resonance (MR) images. Inspired by the success of patch-based sparse representation (SR) in super-resolution image reconstruction, we propose a mapping-based SR (m-SR) framework for standard-dose PET image prediction. Compared with the conventional patch-based SR, our method uses a mapping strategy to ensure that the sparse coefficients, estimated from the multimodal MR images and low-dose PET image, can be applied directly to the prediction of standard-dose PET image. As the mapping between multimodal MR images (or low-dose PET image) and standard-dose PET images can be particularly complex, one step of mapping is often insufficient. To this end, an incremental refinement framework is therefore proposed. Specifically, the predicted standard-dose PET image is further mapped to the target standard-dose PET image, and then the SR is performed again to predict a new standard-dose PET image. This procedure can be repeated for prediction refinement of the iterations. Also, a patch selection based dictionary construction method is further used to speed up the prediction process. The proposed method is validated on a human brain dataset. The experimental results show that our method can outperform benchmark methods in both qualitative and quantitative measures. (paper)

Development of a California commercial building benchmarking database

International Nuclear Information System (INIS)

Kinney, Satkartar; Piette, Mary Ann

2002-01-01

Building energy benchmarking is a useful starting point for commercial building owners and operators to target energy savings opportunities. There are a number of tools and methods for benchmarking energy use. Benchmarking based on regional data can provides more relevant information for California buildings than national tools such as Energy Star. This paper discusses issues related to benchmarking commercial building energy use and the development of Cal-Arch, a building energy benchmarking database for California. Currently Cal-Arch uses existing survey data from California's Commercial End Use Survey (CEUS), a largely underutilized wealth of information collected by California's major utilities. Doe's Commercial Building Energy Consumption Survey (CBECS) is used by a similar tool, Arch, and by a number of other benchmarking tools. Future versions of Arch/Cal-Arch will utilize additional data sources including modeled data and individual buildings to expand the database

ORANGE: a Monte Carlo dose engine for radiotherapy

International Nuclear Information System (INIS)

Zee, W van der; Hogenbirk, A; Marck, S C van der

2005-01-01

This study presents data for the verification of ORANGE, a fast MCNP-based dose engine for radiotherapy treatment planning. In order to verify the new algorithm, it has been benchmarked against DOSXYZ and against measurements. For the benchmarking, first calculations have been done using the ICCR-XIII benchmark. Next, calculations have been done with DOSXYZ and ORANGE in five different phantoms (one homogeneous, two with bone equivalent inserts and two with lung equivalent inserts). The calculations have been done with two mono-energetic photon beams (2 MeV and 6 MeV) and two mono-energetic electron beams (10 MeV and 20 MeV). Comparison of the calculated data (from DOSXYZ and ORANGE) against measurements was possible for a realistic 10 MV photon beam and a realistic 15 MeV electron beam in a homogeneous phantom only. For the comparison of the calculated dose distributions and dose distributions against measurements, the concept of the confidence limit (CL) has been used. This concept reduces the difference between two data sets to a single number, which gives the deviation for 90% of the dose distributions. Using this concept, it was found that ORANGE was always within the statistical bandwidth with DOSXYZ and the measurements. The ICCR-XIII benchmark showed that ORANGE is seven times faster than DOSXYZ, a result comparable with other accelerated Monte Carlo dose systems when no variance reduction is used. As shown for XVMC, using variance reduction techniques has the potential for further acceleration. Using modern computer hardware, this brings the total calculation time for a dose distribution with 1.5% (statistical) accuracy within the clinical range (less then 10 min). This means that ORANGE can be a candidate for a dose engine in radiotherapy treatment planning

Three anisotropic benchmark problems for adaptive finite element methods

Czech Academy of Sciences Publication Activity Database

Šolín, Pavel; Čertík, O.; Korous, L.

2013-01-01

Roč. 219, č. 13 (2013), s. 7286-7295 ISSN 0096-3003 R&D Projects: GA AV ČR IAA100760702 Institutional support: RVO:61388998 Keywords : benchmark problem * anisotropic solution * boundary layer Subject RIV: BA - General Mathematics Impact factor: 1.600, year: 2013

Alignment methods: strategies, challenges, benchmarking, and comparative overview.

Science.gov (United States)

Löytynoja, Ari

2012-01-01

Comparative evolutionary analyses of molecular sequences are solely based on the identities and differences detected between homologous characters. Errors in this homology statement, that is errors in the alignment of the sequences, are likely to lead to errors in the downstream analyses. Sequence alignment and phylogenetic inference are tightly connected and many popular alignment programs use the phylogeny to divide the alignment problem into smaller tasks. They then neglect the phylogenetic tree, however, and produce alignments that are not evolutionarily meaningful. The use of phylogeny-aware methods reduces the error but the resulting alignments, with evolutionarily correct representation of homology, can challenge the existing practices and methods for viewing and visualising the sequences. The inter-dependency of alignment and phylogeny can be resolved by joint estimation of the two; methods based on statistical models allow for inferring the alignment parameters from the data and correctly take into account the uncertainty of the solution but remain computationally challenging. Widely used alignment methods are based on heuristic algorithms and unlikely to find globally optimal solutions. The whole concept of one correct alignment for the sequences is questionable, however, as there typically exist vast numbers of alternative, roughly equally good alignments that should also be considered. This uncertainty is hidden by many popular alignment programs and is rarely correctly taken into account in the downstream analyses. The quest for finding and improving the alignment solution is complicated by the lack of suitable measures of alignment goodness. The difficulty of comparing alternative solutions also affects benchmarks of alignment methods and the results strongly depend on the measure used. As the effects of alignment error cannot be predicted, comparing the alignments' performance in downstream analyses is recommended.

Dynamic Rupture Benchmarking of the ADER-DG Method

Science.gov (United States)

Gabriel, Alice; Pelties, Christian

2013-04-01

We will verify the arbitrary high-order derivative Discontinuous Galerkin (ADER-DG) method in various test cases of the 'SCEC/USGS Dynamic Earthquake Rupture Code Verification Exercise' benchmark suite (Harris et al. 2009). The ADER-DG scheme is able to solve the spontaneous rupture problem with high-order accuracy in space and time on three-dimensional unstructured tetrahedral meshes. Strong mesh coarsening or refinement at areas of interest can be applied to keep the computational costs feasible. Moreover, the method does not generate spurious high-frequency contributions in the slip rate spectra and therefore does not require any artificial damping as demonstrated in previous presentations and publications (Pelties et al. 2010 and 2012). We will show that the mentioned features hold also for more advanced setups as e.g. a branching fault system, heterogeneous background stresses and bimaterial faults. The advanced geometrical flexibility combined with an enhanced accuracy will make the ADER-DG method a useful tool to study earthquake dynamics on complex fault systems in realistic rheologies. References: Harris, R.A., M. Barall, R. Archuleta, B. Aagaard, J.-P. Ampuero, H. Bhat, V. Cruz-Atienza, L. Dalguer, P. Dawson, S. Day, B. Duan, E. Dunham, G. Ely, Y. Kaneko, Y. Kase, N. Lapusta, Y. Liu, S. Ma, D. Oglesby, K. Olsen, A. Pitarka, S. Song, and E. Templeton, The SCEC/USGS Dynamic Earthquake Rupture Code Verification Exercise, Seismological Research Letters, vol. 80, no. 1, pages 119-126, 2009 Pelties, C., J. de la Puente, and M. Kaeser, Dynamic Rupture Modeling in Three Dimensions on Unstructured Meshes Using a Discontinuous Galerkin Method, AGU 2010 Fall Meeting, abstract #S21C-2068 Pelties, C., J. de la Puente, J.-P. Ampuero, G. Brietzke, and M. Kaeser, Three-Dimensional Dynamic Rupture Simulation with a High-order Discontinuous Galerkin Method on Unstructured Tetrahedral Meshes, JGR. - Solid Earth, VOL. 117, B02309, 2012

Development of a California commercial building benchmarking database

Energy Technology Data Exchange (ETDEWEB)

Kinney, Satkartar; Piette, Mary Ann

2002-05-17

Building energy benchmarking is a useful starting point for commercial building owners and operators to target energy savings opportunities. There are a number of tools and methods for benchmarking energy use. Benchmarking based on regional data can provides more relevant information for California buildings than national tools such as Energy Star. This paper discusses issues related to benchmarking commercial building energy use and the development of Cal-Arch, a building energy benchmarking database for California. Currently Cal-Arch uses existing survey data from California's Commercial End Use Survey (CEUS), a largely underutilized wealth of information collected by California's major utilities. Doe's Commercial Building Energy Consumption Survey (CBECS) is used by a similar tool, Arch, and by a number of other benchmarking tools. Future versions of Arch/Cal-Arch will utilize additional data sources including modeled data and individual buildings to expand the database.

Benchmarking burnup reconstruction methods for dynamically operated research reactors

Energy Technology Data Exchange (ETDEWEB)

Sternat, Matthew R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Charlton, William S. [Univ. of Nebraska, Lincoln, NE (United States). National Strategic Research Institute; Nichols, Theodore F. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2016-03-01

The burnup of an HEU fueled dynamically operated research reactor, the Oak Ridge Research Reactor, was experimentally reconstructed using two different analytic methodologies and a suite of signature isotopes to evaluate techniques for estimating burnup for research reactor fuel. The methods studied include using individual signature isotopes and the complete mass spectrometry spectrum to recover the sample’s burnup. The individual, or sets of, isotopes include ¹⁴⁸Nd, ¹³⁷Cs+¹³⁷Ba, ¹³⁹La, and ¹⁴⁵Nd+¹⁴⁶Nd. The storage documentation from the analyzed fuel material provided two different measures of burnup: burnup percentage and the total power generated from the assembly in MWd. When normalized to conventional units, these two references differed by 7.8% (395.42GWd/MTHM and 426.27GWd/MTHM) in the resulting burnup for the spent fuel element used in the benchmark. Among all methods being evaluated, the results were within 11.3% of either reference burnup. The results were mixed in closeness to both reference burnups; however, consistent results were achieved from all three experimental samples.

Benchmark of PENELOPE code for low-energy photon transport: dose comparisons with MCNP4 and EGS4

International Nuclear Information System (INIS)

Ye, Sung-Joon; Brezovich, Ivan A; Pareek, Prem; Naqvi, Shahid A

2004-01-01

The expanding clinical use of low-energy photon emitting 125 I and 103 Pd seeds in recent years has led to renewed interest in their dosimetric properties. Numerous papers pointed out that higher accuracy could be obtained in Monte Carlo simulations by utilizing newer libraries for the low-energy photon cross-sections, such as XCOM and EPDL97. The recently developed PENELOPE 2001 Monte Carlo code is user friendly and incorporates photon cross-section data from the EPDL97. The code has been verified for clinical dosimetry of high-energy electron and photon beams, but has not yet been tested at low energies. In the present work, we have benchmarked the PENELOPE code for 10-150 keV photons. We computed radial dose distributions from 0 to 10 cm in water at photon energies of 10-150 keV using both PENELOPE and MCNP4C with either DLC-146 or DLC-200 cross-section libraries, assuming a point source located at the centre of a 30 cm diameter and 20 cm length cylinder. Throughout the energy range of simulated photons (except for 10 keV), PENELOPE agreed within statistical uncertainties (at worst ±5%) with MCNP/DLC-146 in the entire region of 1-10 cm and with published EGS4 data up to 5 cm. The dose at 1 cm (or dose rate constant) of PENELOPE agreed with MCNP/DLC-146 and EGS4 data within approximately ±2% in the range of 20-150 keV, while MCNP/DLC-200 produced values up to 9% lower in the range of 20-100 keV than PENELOPE or the other codes. However, the differences among the four datasets became negligible above 100 keV

Benchmark of PENELOPE code for low-energy photon transport: dose comparisons with MCNP4 and EGS4.

Science.gov (United States)

Ye, Sung-Joon; Brezovich, Ivan A; Pareek, Prem; Naqvi, Shahid A

2004-02-07

The expanding clinical use of low-energy photon emitting 125I and 103Pd seeds in recent years has led to renewed interest in their dosimetric properties. Numerous papers pointed out that higher accuracy could be obtained in Monte Carlo simulations by utilizing newer libraries for the low-energy photon cross-sections, such as XCOM and EPDL97. The recently developed PENELOPE 2001 Monte Carlo code is user friendly and incorporates photon cross-section data from the EPDL97. The code has been verified for clinical dosimetry of high-energy electron and photon beams, but has not yet been tested at low energies. In the present work, we have benchmarked the PENELOPE code for 10-150 keV photons. We computed radial dose distributions from 0 to 10 cm in water at photon energies of 10-150 keV using both PENELOPE and MCNP4C with either DLC-146 or DLC-200 cross-section libraries, assuming a point source located at the centre of a 30 cm diameter and 20 cm length cylinder. Throughout the energy range of simulated photons (except for 10 keV), PENELOPE agreed within statistical uncertainties (at worst +/- 5%) with MCNP/DLC-146 in the entire region of 1-10 cm and with published EGS4 data up to 5 cm. The dose at 1 cm (or dose rate constant) of PENELOPE agreed with MCNP/DLC-146 and EGS4 data within approximately +/- 2% in the range of 20-150 keV, while MCNP/DLC-200 produced values up to 9% lower in the range of 20-100 keV than PENELOPE or the other codes. However, the differences among the four datasets became negligible above 100 keV.

SMORN-III benchmark test on reactor noise analysis methods

International Nuclear Information System (INIS)

Shinohara, Yoshikuni; Hirota, Jitsuya

1984-02-01

A computational benchmark test was performed in conjunction with the Third Specialists Meeting on Reactor Noise (SMORN-III) which was held in Tokyo, Japan in October 1981. This report summarizes the results of the test as well as the works made for preparation of the test. (author)

PMLB: a large benchmark suite for machine learning evaluation and comparison.

Science.gov (United States)

Olson, Randal S; La Cava, William; Orzechowski, Patryk; Urbanowicz, Ryan J; Moore, Jason H

2017-01-01

The selection, development, or comparison of machine learning methods in data mining can be a difficult task based on the target problem and goals of a particular study. Numerous publicly available real-world and simulated benchmark datasets have emerged from different sources, but their organization and adoption as standards have been inconsistent. As such, selecting and curating specific benchmarks remains an unnecessary burden on machine learning practitioners and data scientists. The present study introduces an accessible, curated, and developing public benchmark resource to facilitate identification of the strengths and weaknesses of different machine learning methodologies. We compare meta-features among the current set of benchmark datasets in this resource to characterize the diversity of available data. Finally, we apply a number of established machine learning methods to the entire benchmark suite and analyze how datasets and algorithms cluster in terms of performance. From this study, we find that existing benchmarks lack the diversity to properly benchmark machine learning algorithms, and there are several gaps in benchmarking problems that still need to be considered. This work represents another important step towards understanding the limitations of popular benchmarking suites and developing a resource that connects existing benchmarking standards to more diverse and efficient standards in the future.

Benchmarking in University Toolbox

Directory of Open Access Journals (Sweden)

Katarzyna Kuźmicz

2015-06-01

Full Text Available In the face of global competition and rising challenges that higher education institutions (HEIs meet, it is imperative to increase innovativeness and efficiency of their management. Benchmarking can be the appropriate tool to search for a point of reference necessary to assess institution’s competitive position and learn from the best in order to improve. The primary purpose of the paper is to present in-depth analysis of benchmarking application in HEIs worldwide. The study involves indicating premises of using benchmarking in HEIs. It also contains detailed examination of types, approaches and scope of benchmarking initiatives. The thorough insight of benchmarking applications enabled developing classification of benchmarking undertakings in HEIs. The paper includes review of the most recent benchmarking projects and relating them to the classification according to the elaborated criteria (geographical range, scope, type of data, subject, support and continuity. The presented examples were chosen in order to exemplify different approaches to benchmarking in higher education setting. The study was performed on the basis of the published reports from benchmarking projects, scientific literature and the experience of the author from the active participation in benchmarking projects. The paper concludes with recommendations for university managers undertaking benchmarking, derived on the basis of the conducted analysis.

Vver-1000 Mox core computational benchmark

International Nuclear Information System (INIS)

2006-01-01

The NEA Nuclear Science Committee has established an Expert Group that deals with the status and trends of reactor physics, fuel performance and fuel cycle issues related to disposing of weapons-grade plutonium in mixed-oxide fuel. The objectives of the group are to provide NEA member countries with up-to-date information on, and to develop consensus regarding, core and fuel cycle issues associated with burning weapons-grade plutonium in thermal water reactors (PWR, BWR, VVER-1000, CANDU) and fast reactors (BN-600). These issues concern core physics, fuel performance and reliability, and the capability and flexibility of thermal water reactors and fast reactors to dispose of weapons-grade plutonium in standard fuel cycles. The activities of the NEA Expert Group on Reactor-based Plutonium Disposition are carried out in close co-operation (jointly, in most cases) with the NEA Working Party on Scientific Issues in Reactor Systems (WPRS). A prominent part of these activities include benchmark studies. At the time of preparation of this report, the following benchmarks were completed or in progress: VENUS-2 MOX Core Benchmarks: carried out jointly with the WPRS (formerly the WPPR) (completed); VVER-1000 LEU and MOX Benchmark (completed); KRITZ-2 Benchmarks: carried out jointly with the WPRS (formerly the WPPR) (completed); Hollow and Solid MOX Fuel Behaviour Benchmark (completed); PRIMO MOX Fuel Performance Benchmark (ongoing); VENUS-2 MOX-fuelled Reactor Dosimetry Calculation (ongoing); VVER-1000 In-core Self-powered Neutron Detector Calculational Benchmark (started); MOX Fuel Rod Behaviour in Fast Power Pulse Conditions (started); Benchmark on the VENUS Plutonium Recycling Experiments Configuration 7 (started). This report describes the detailed results of the benchmark investigating the physics of a whole VVER-1000 reactor core using two-thirds low-enriched uranium (LEU) and one-third MOX fuel. It contributes to the computer code certification process and to the

In silico toxicology: comprehensive benchmarking of multi-label classification methods applied to chemical toxicity data

KAUST Repository

Raies, Arwa B.

2017-12-05

One goal of toxicity testing, among others, is identifying harmful effects of chemicals. Given the high demand for toxicity tests, it is necessary to conduct these tests for multiple toxicity endpoints for the same compound. Current computational toxicology methods aim at developing models mainly to predict a single toxicity endpoint. When chemicals cause several toxicity effects, one model is generated to predict toxicity for each endpoint, which can be labor and computationally intensive when the number of toxicity endpoints is large. Additionally, this approach does not take into consideration possible correlation between the endpoints. Therefore, there has been a recent shift in computational toxicity studies toward generating predictive models able to predict several toxicity endpoints by utilizing correlations between these endpoints. Applying such correlations jointly with compounds\\' features may improve model\\'s performance and reduce the number of required models. This can be achieved through multi-label classification methods. These methods have not undergone comprehensive benchmarking in the domain of predictive toxicology. Therefore, we performed extensive benchmarking and analysis of over 19,000 multi-label classification models generated using combinations of the state-of-the-art methods. The methods have been evaluated from different perspectives using various metrics to assess their effectiveness. We were able to illustrate variability in the performance of the methods under several conditions. This review will help researchers to select the most suitable method for the problem at hand and provide a baseline for evaluating new approaches. Based on this analysis, we provided recommendations for potential future directions in this area.

In silico toxicology: comprehensive benchmarking of multi-label classification methods applied to chemical toxicity data

KAUST Repository

Raies, Arwa B.; Bajic, Vladimir B.

2017-01-01

One goal of toxicity testing, among others, is identifying harmful effects of chemicals. Given the high demand for toxicity tests, it is necessary to conduct these tests for multiple toxicity endpoints for the same compound. Current computational toxicology methods aim at developing models mainly to predict a single toxicity endpoint. When chemicals cause several toxicity effects, one model is generated to predict toxicity for each endpoint, which can be labor and computationally intensive when the number of toxicity endpoints is large. Additionally, this approach does not take into consideration possible correlation between the endpoints. Therefore, there has been a recent shift in computational toxicity studies toward generating predictive models able to predict several toxicity endpoints by utilizing correlations between these endpoints. Applying such correlations jointly with compounds' features may improve model's performance and reduce the number of required models. This can be achieved through multi-label classification methods. These methods have not undergone comprehensive benchmarking in the domain of predictive toxicology. Therefore, we performed extensive benchmarking and analysis of over 19,000 multi-label classification models generated using combinations of the state-of-the-art methods. The methods have been evaluated from different perspectives using various metrics to assess their effectiveness. We were able to illustrate variability in the performance of the methods under several conditions. This review will help researchers to select the most suitable method for the problem at hand and provide a baseline for evaluating new approaches. Based on this analysis, we provided recommendations for potential future directions in this area.

Supermarket Refrigeration System - Benchmark for Hybrid System Control

DEFF Research Database (Denmark)

Sloth, Lars Finn; Izadi-Zamanabadi, Roozbeh; Wisniewski, Rafal

2007-01-01

This paper presents a supermarket refrigeration system as a benchmark for development of new ideas and a comparison of methods for hybrid systems' modeling and control. The benchmark features switch dynamics and discrete valued input making it a hybrid system, furthermore the outputs are subjected...

Benchmarking of refinery emissions performance : Executive summary

International Nuclear Information System (INIS)

2003-07-01

This study was undertaken to collect emissions performance data for Canadian and comparable American refineries. The objective was to examine parameters that affect refinery air emissions performance and develop methods or correlations to normalize emissions performance. Another objective was to correlate and compare the performance of Canadian refineries to comparable American refineries. For the purpose of this study, benchmarking involved the determination of levels of emission performance that are being achieved for generic groups of facilities. A total of 20 facilities were included in the benchmarking analysis, and 74 American refinery emission correlations were developed. The recommended benchmarks, and the application of those correlations for comparison between Canadian and American refinery performance, were discussed. The benchmarks were: sulfur oxides, nitrogen oxides, carbon monoxide, particulate, volatile organic compounds, ammonia and benzene. For each refinery in Canada, benchmark emissions were developed. Several factors can explain differences in Canadian and American refinery emission performance. 4 tabs., 7 figs

Library Benchmarking

Directory of Open Access Journals (Sweden)

Wiji Suwarno

2017-02-01

Full Text Available The term benchmarking has been encountered in the implementation of total quality (TQM or in Indonesian termed holistic quality management because benchmarking is a tool to look for ideas or learn from the library. Benchmarking is a processof measuring and comparing for continuous business process of systematic and continuous measurement, the process of measuring and comparing for continuous business process of an organization to get information that can help these organization improve their performance efforts.

Epidemiological methods for assessing dose-response and dose-effect relationships

DEFF Research Database (Denmark)

Kjellström, Tord; Grandjean, Philippe

2007-01-01

Selected Molecular Mechanisms of Metal Toxicity and Carcinogenicity General Considerations of Dose-Effect and Dose-Response Relationships Interactions in Metal Toxicology Epidemiological Methods for Assessing Dose-Response and Dose-Effect Relationships Essential Metals: Assessing Risks from Deficiency......Description Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements...... access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. Audience Toxicologists, physicians, and engineers in the fields of environmental and occupational health as well as libraries in these disciplines. Will also be a useful...

Method of simulating dose reduction for digital radiographic systems

International Nuclear Information System (INIS)

Baath, M.; Haakansson, M.; Tingberg, A.; Maansson, L. G.

2005-01-01

The optimisation of image quality vs. radiation dose is an important task in medical imaging. To obtain maximum validity of the optimisation, it must be based on clinical images. Images at different dose levels can then either be obtained by collecting patient images at the different dose levels sought to investigate - including additional exposures and permission from an ethical committee - or by manipulating images to simulate different dose levels. The aim of the present work was to develop a method of simulating dose reduction for digital radiographic systems. The method uses information about the detective quantum efficiency and noise power spectrum at the original and simulated dose levels to create an image containing filtered noise. When added to the original image this results in an image with noise which, in terms of frequency content, agrees with the noise present in an image collected at the simulated dose level. To increase the validity, the method takes local dose variations in the original image into account. The method was tested on a computed radiography system and was shown to produce images with noise behaviour similar to that of images actually collected at the simulated dose levels. The method can, therefore, be used to modify an image collected at one dose level so that it simulates an image of the same object collected at any lower dose level. (authors)

FENDL neutronics benchmark: Specifications for the calculational neutronics and shielding benchmark

International Nuclear Information System (INIS)

Sawan, M.E.

1994-12-01

During the IAEA Advisory Group Meeting on ''Improved Evaluations and Integral Data Testing for FENDL'' held in Garching near Munich, Germany in the period 12-16 September 1994, the Working Group II on ''Experimental and Calculational Benchmarks on Fusion Neutronics for ITER'' recommended that a calculational benchmark representative of the ITER design should be developed. This report describes the neutronics and shielding calculational benchmark available for scientists interested in performing analysis for this benchmark. (author)

Calculation methods for determining dose equivalent

International Nuclear Information System (INIS)

Endres, G.W.R.; Tanner, J.E.; Scherpelz, R.I.; Hadlock, D.E.

1988-01-01

A series of calculations of neutron fluence as a function of energy in an anthropomorphic phantom was performed to develop a system for determining effective dose equivalent for external radiation sources. critical organ dose equivalents are calculated and effective dose equivalents are determined using ICRP-26 methods. Quality factors based on both present definitions and ICRP-40 definitions are used in the analysis. The results of these calculations are presented and discussed

A 3D stylized half-core CANDU benchmark problem

International Nuclear Information System (INIS)

Pounders, Justin M.; Rahnema, Farzad; Serghiuta, Dumitru; Tholammakkil, John

2011-01-01

A 3D stylized half-core Canadian deuterium uranium (CANDU) reactor benchmark problem is presented. The benchmark problem is comprised of a heterogeneous lattice of 37-element natural uranium fuel bundles, heavy water moderated, heavy water cooled, with adjuster rods included as reactivity control devices. Furthermore, a 2-group macroscopic cross section library has been developed for the problem to increase the utility of this benchmark for full-core deterministic transport methods development. Monte Carlo results are presented for the benchmark problem in cooled, checkerboard void, and full coolant void configurations.

INTEGRAL BENCHMARKS AVAILABLE THROUGH THE INTERNATIONAL REACTOR PHYSICS EXPERIMENT EVALUATION PROJECT AND THE INTERNATIONAL CRITICALITY SAFETY BENCHMARK EVALUATION PROJECT

Energy Technology Data Exchange (ETDEWEB)

J. Blair Briggs; Lori Scott; Enrico Sartori; Yolanda Rugama

2008-09-01

Interest in high-quality integral benchmark data is increasing as efforts to quantify and reduce calculational uncertainties accelerate to meet the demands of next generation reactor and advanced fuel cycle concepts. The International Reactor Physics Experiment Evaluation Project (IRPhEP) and the International Criticality Safety Benchmark Evaluation Project (ICSBEP) continue to expand their efforts and broaden their scope to identify, evaluate, and provide integral benchmark data for method and data validation. Benchmark model specifications provided by these two projects are used heavily by the international reactor physics, nuclear data, and criticality safety communities. Thus far, 14 countries have contributed to the IRPhEP, and 20 have contributed to the ICSBEP. The status of the IRPhEP and ICSBEP is discussed in this paper, and the future of the two projects is outlined and discussed. Selected benchmarks that have been added to the IRPhEP and ICSBEP handbooks since PHYSOR’06 are highlighted, and the future of the two projects is discussed.

INTEGRAL BENCHMARKS AVAILABLE THROUGH THE INTERNATIONAL REACTOR PHYSICS EXPERIMENT EVALUATION PROJECT AND THE INTERNATIONAL CRITICALITY SAFETY BENCHMARK EVALUATION PROJECT

International Nuclear Information System (INIS)

J. Blair Briggs; Lori Scott; Enrico Sartori; Yolanda Rugama

2008-01-01

Interest in high-quality integral benchmark data is increasing as efforts to quantify and reduce calculational uncertainties accelerate to meet the demands of next generation reactor and advanced fuel cycle concepts. The International Reactor Physics Experiment Evaluation Project (IRPhEP) and the International Criticality Safety Benchmark Evaluation Project (ICSBEP) continue to expand their efforts and broaden their scope to identify, evaluate, and provide integral benchmark data for method and data validation. Benchmark model specifications provided by these two projects are used heavily by the international reactor physics, nuclear data, and criticality safety communities. Thus far, 14 countries have contributed to the IRPhEP, and 20 have contributed to the ICSBEP. The status of the IRPhEP and ICSBEP is discussed in this paper, and the future of the two projects is outlined and discussed. Selected benchmarks that have been added to the IRPhEP and ICSBEP handbooks since PHYSOR-06 are highlighted, and the future of the two projects is discussed

The Mutual Benchmarking Method for Smes’ Competitive Strategy Development

Directory of Open Access Journals (Sweden)

Rostek Katarzyna

2013-12-01

Full Text Available Competitive advantage is a relative feature, evaluated in respect of other competing enterprises. The gaining of sustainable competitive advantage is conditioned by knowledge of own performance and the results of the competitive environment. SMEs have limited opportunities to obtain such information on their own. The method of mutual benchmarking changes this situation by introducing the collaborative network. The aim of the cooperation is to support each of the group members to achieve sustainable competitive advantage, which is the result of a conscious strategy, and not only a matter of chance. This cooperation is based on the collecting and processing of data and sharing information through a common IT platform: for example, a group of Polish SMEs was shown how to implement such a common IT solution and how to provide the information preparing within the proposed service. The whole is a complete proposal for effective support of creating a competitive strategy in SMEs.

Numerical simulations of concrete flow: A benchmark comparison

DEFF Research Database (Denmark)

Roussel, Nicolas; Gram, Annika; Cremonesi, Massimiliano

2016-01-01

First, we define in this paper two benchmark flows readily usable by anyone calibrating a numerical tool for concrete flow prediction. Such benchmark flows shall allow anyone to check the validity of their computational tools no matter the numerical methods and parameters they choose. Second, we ...

Benchmarking Variable Selection in QSAR.

Science.gov (United States)

Eklund, Martin; Norinder, Ulf; Boyer, Scott; Carlsson, Lars

2012-02-01

Variable selection is important in QSAR modeling since it can improve model performance and transparency, as well as reduce the computational cost of model fitting and predictions. Which variable selection methods that perform well in QSAR settings is largely unknown. To address this question we, in a total of 1728 benchmarking experiments, rigorously investigated how eight variable selection methods affect the predictive performance and transparency of random forest models fitted to seven QSAR datasets covering different endpoints, descriptors sets, types of response variables, and number of chemical compounds. The results show that univariate variable selection methods are suboptimal and that the number of variables in the benchmarked datasets can be reduced with about 60 % without significant loss in model performance when using multivariate adaptive regression splines MARS and forward selection. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Introducing a Generic Concept for an Online IT-Benchmarking System

OpenAIRE

Ziaie, Pujan;Ziller, Markus;Wollersheim, Jan;Krcmar, Helmut

2014-01-01

While IT benchmarking has grown considerably in the last few years, conventional benchmarking tools have not been able to adequately respond to the rapid changes in technology and paradigm shifts in IT-related domains. This paper aims to review benchmarking methods and leverage design science methodology to present design elements for a novel software solution in the field of IT benchmarking. The solution, which introduces a concept for generic (service-independent) indicators is based on and...

Benchmarking in the Netherlands

International Nuclear Information System (INIS)

1999-01-01

In two articles an overview is given of the activities in the Dutch industry and energy sector with respect to benchmarking. In benchmarking operational processes of different competitive businesses are compared to improve your own performance. Benchmark covenants for energy efficiency between the Dutch government and industrial sectors contribute to a growth of the number of benchmark surveys in the energy intensive industry in the Netherlands. However, some doubt the effectiveness of the benchmark studies

Deflection-based method for seismic response analysis of concrete walls: Benchmarking of CAMUS experiment

International Nuclear Information System (INIS)

Basu, Prabir C.; Roshan, A.D.

2007-01-01

A number of shake table tests had been conducted on the scaled down model of a concrete wall as part of CAMUS experiment. The experiments were conducted between 1996 and 1998 in the CEA facilities in Saclay, France. Benchmarking of CAMUS experiments was undertaken as a part of the coordinated research program on 'Safety Significance of Near-Field Earthquakes' organised by International Atomic Energy Agency (IAEA). Technique of deflection-based method was adopted for benchmarking exercise. Non-linear static procedure of deflection-based method has two basic steps: pushover analysis, and determination of target displacement or performance point. Pushover analysis is an analytical procedure to assess the capacity to withstand seismic loading effect that a structural system can offer considering the redundancies and inelastic deformation. Outcome of a pushover analysis is the plot of force-displacement (base shear-top/roof displacement) curve of the structure. This is obtained by step-by-step non-linear static analysis of the structure with increasing value of load. The second step is to determine target displacement, which is also known as performance point. The target displacement is the likely maximum displacement of the structure due to a specified seismic input motion. Established procedures, FEMA-273 and ATC-40, are available to determine this maximum deflection. The responses of CAMUS test specimen are determined by deflection-based method and analytically calculated values compare well with the test results

The experimental method for neutron dose-equivalent detection

International Nuclear Information System (INIS)

Ji Changsong

1992-01-01

A new method, for getting neutron dose-equivalent Cd rode absorption method is described. The method adopts Cd-rode-swarm buck absorption, which greatly improved the neutron sensitivity and simplified the adjustment method. By this method, the author has developed BH3105 model neutron dose equivalent meter, the sensitivity of this instrument reach 10 cps/μSvh -1 . γ-ray depression rate reaches 4000:1, the measurement range is 0.1 μSv/h-10 6 μSv/h. The energy response is good (from thermal neutron-14 MeV neutron), this instrument can be used to measure the dose equivalent of the neutron areas

MoleculeNet: a benchmark for molecular machine learning.

Science.gov (United States)

Wu, Zhenqin; Ramsundar, Bharath; Feinberg, Evan N; Gomes, Joseph; Geniesse, Caleb; Pappu, Aneesh S; Leswing, Karl; Pande, Vijay

2018-01-14

Molecular machine learning has been maturing rapidly over the last few years. Improved methods and the presence of larger datasets have enabled machine learning algorithms to make increasingly accurate predictions about molecular properties. However, algorithmic progress has been limited due to the lack of a standard benchmark to compare the efficacy of proposed methods; most new algorithms are benchmarked on different datasets making it challenging to gauge the quality of proposed methods. This work introduces MoleculeNet, a large scale benchmark for molecular machine learning. MoleculeNet curates multiple public datasets, establishes metrics for evaluation, and offers high quality open-source implementations of multiple previously proposed molecular featurization and learning algorithms (released as part of the DeepChem open source library). MoleculeNet benchmarks demonstrate that learnable representations are powerful tools for molecular machine learning and broadly offer the best performance. However, this result comes with caveats. Learnable representations still struggle to deal with complex tasks under data scarcity and highly imbalanced classification. For quantum mechanical and biophysical datasets, the use of physics-aware featurizations can be more important than choice of particular learning algorithm.

Benchmark validation of statistical models: Application to mediation analysis of imagery and memory.

Science.gov (United States)

MacKinnon, David P; Valente, Matthew J; Wurpts, Ingrid C

2018-03-29

This article describes benchmark validation, an approach to validating a statistical model. According to benchmark validation, a valid model generates estimates and research conclusions consistent with a known substantive effect. Three types of benchmark validation-(a) benchmark value, (b) benchmark estimate, and (c) benchmark effect-are described and illustrated with examples. Benchmark validation methods are especially useful for statistical models with assumptions that are untestable or very difficult to test. Benchmark effect validation methods were applied to evaluate statistical mediation analysis in eight studies using the established effect that increasing mental imagery improves recall of words. Statistical mediation analysis led to conclusions about mediation that were consistent with established theory that increased imagery leads to increased word recall. Benchmark validation based on established substantive theory is discussed as a general way to investigate characteristics of statistical models and a complement to mathematical proof and statistical simulation. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

A NRC-BNL benchmark evaluation of seismic analysis methods for non-classically damped coupled systems

International Nuclear Information System (INIS)

Xu, J.; DeGrassi, G.; Chokshi, N.

2004-01-01

Under the auspices of the U.S. Nuclear Regulatory Commission (NRC), Brookhaven National Laboratory (BNL) developed a comprehensive program to evaluate state-of-the-art methods and computer programs for seismic analysis of typical coupled nuclear power plant (NPP) systems with non-classical damping. In this program, four benchmark models of coupled building-piping/equipment systems with different damping characteristics were developed and analyzed by BNL for a suite of earthquakes. The BNL analysis was carried out by the Wilson-θ time domain integration method with the system-damping matrix computed using a synthesis formulation as presented in a companion paper [Nucl. Eng. Des. (2002)]. These benchmark problems were subsequently distributed to and analyzed by program participants applying their uniquely developed methods and computer programs. This paper is intended to offer a glimpse at the program, and provide a summary of major findings and principle conclusions with some representative results. The participant's analysis results established using complex modal time history methods showed good comparison with the BNL solutions, while the analyses produced with either complex-mode response spectrum methods or classical normal-mode response spectrum method, in general, produced more conservative results, when averaged over a suite of earthquakes. However, when coupling due to damping is significant, complex-mode response spectrum methods performed better than the classical normal-mode response spectrum method. Furthermore, as part of the program objectives, a parametric assessment is also presented in this paper, aimed at evaluation of the applicability of various analysis methods to problems with different dynamic characteristics unique to coupled NPP systems. It is believed that the findings and insights learned from this program will be useful in developing new acceptance criteria and providing guidance for future regulatory activities involving license

WLUP benchmarks

International Nuclear Information System (INIS)

Leszczynski, Francisco

2002-01-01

The IAEA-WIMS Library Update Project (WLUP) is on the end stage. The final library will be released on 2002. It is a result of research and development made by more than ten investigators during 10 years. The organization of benchmarks for testing and choosing the best set of data has been coordinated by the author of this paper. It is presented the organization, name conventions, contents and documentation of WLUP benchmarks, and an updated list of the main parameters for all cases. First, the benchmarks objectives and types are given. Then, comparisons of results from different WIMSD libraries are included. Finally it is described the program QVALUE for analysis and plot of results. Some examples are given. The set of benchmarks implemented on this work is a fundamental tool for testing new multigroup libraries. (author)

EU and OECD benchmarking and peer review compared

NARCIS (Netherlands)

Groenendijk, Nico

2009-01-01

Benchmarking and peer review are essential elements of the so-called EU open method of coordination (OMC) which has been contested in the literature for lack of effectiveness. In this paper we compare benchmarking and peer review procedures as used by the EU with those used by the OECD. Different

Benchmarking the Remote-Handled Waste Facility at the West Valley Demonstration Project

International Nuclear Information System (INIS)

Mendiratta, O.P.; Ploetz, D.K.

2000-01-01

ABSTRACT Facility decontamination activities at the West Valley Demonstration Project (WVDP), the site of a former commercial nuclear spent fuel reprocessing facility near Buffalo, New York, have resulted in the removal of radioactive waste. Due to high dose and/or high contamination levels of this waste, it needs to be handled remotely for processing and repackaging into transport/disposal-ready containers. An initial conceptual design for a Remote-Handled Waste Facility (RHWF), completed in June 1998, was estimated to cost $55 million and take 11 years to process the waste. Benchmarking the RHWF with other facilities around the world, completed in November 1998, identified unique facility design features and innovative waste processing methods. Incorporation of the benchmarking effort has led to a smaller yet fully functional, $31 million facility. To distinguish it from the June 1998 version, the revised design is called the Rescoped Remote-Handled Waste Facility (RRHWF) in this topical report. The conceptual design for the RRHWF was completed in June 1999. A design-build contract was approved by the Department of Energy in September 1999

Benchmarking the Remote-Handled Waste Facility at the West Valley Demonstration Project

Energy Technology Data Exchange (ETDEWEB)

O. P. Mendiratta; D. K. Ploetz

2000-02-29

ABSTRACT Facility decontamination activities at the West Valley Demonstration Project (WVDP), the site of a former commercial nuclear spent fuel reprocessing facility near Buffalo, New York, have resulted in the removal of radioactive waste. Due to high dose and/or high contamination levels of this waste, it needs to be handled remotely for processing and repackaging into transport/disposal-ready containers. An initial conceptual design for a Remote-Handled Waste Facility (RHWF), completed in June 1998, was estimated to cost $55 million and take 11 years to process the waste. Benchmarking the RHWF with other facilities around the world, completed in November 1998, identified unique facility design features and innovative waste pro-cessing methods. Incorporation of the benchmarking effort has led to a smaller yet fully functional, $31 million facility. To distinguish it from the June 1998 version, the revised design is called the Rescoped Remote-Handled Waste Facility (RRHWF) in this topical report. The conceptual design for the RRHWF was completed in June 1999. A design-build contract was approved by the Department of Energy in September 1999.

Benchmarking Dosimetric Quality Assessment of Prostate Intensity-Modulated Radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Senthi, Sashendra, E-mail: sasha.senthi@petermac.org [Division of Radiation Oncology, Peter MacCallum Cancer Center, East Melbourne, VIC (Australia); Gill, Suki S. [Division of Radiation Oncology, Peter MacCallum Cancer Center, East Melbourne, VIC (Australia); Haworth, Annette; Kron, Tomas; Cramb, Jim [Department of Physical Sciences, Peter MacCallum Cancer Center, East Melbourne, VIC (Australia); Rolfo, Aldo [Radiation Therapy Services, Peter MacCallum Cancer Center, East Melbourne, VIC (Australia); Thomas, Jessica [Biostatistics and Clinical Trials, Peter MacCallum Cancer Center, East Melbourne, VIC (Australia); Duchesne, Gillian M. [Division of Radiation Oncology, Peter MacCallum Cancer Center, East Melbourne, VIC (Australia); Hamilton, Christopher H.; Joon, Daryl Lim [Radiation Oncology Department, Austin Repatriation Hospital, Heidelberg, VIC (Australia); Bowden, Patrick [Radiation Oncology Department, Tattersall' s Cancer Center, East Melbourne, VIC (Australia); Foroudi, Farshad [Division of Radiation Oncology, Peter MacCallum Cancer Center, East Melbourne, VIC (Australia)

2012-02-01

Purpose: To benchmark the dosimetric quality assessment of prostate intensity-modulated radiotherapy and determine whether the quality is influenced by disease or treatment factors. Patients and Methods: We retrospectively analyzed the data from 155 consecutive men treated radically for prostate cancer using intensity-modulated radiotherapy to 78 Gy between January 2007 and March 2009 across six radiotherapy treatment centers. The plan quality was determined by the measures of coverage, homogeneity, and conformity. Tumor coverage was measured using the planning target volume (PTV) receiving 95% and 100% of the prescribed dose (V{sub 95%} and V{sub 100%}, respectively) and the clinical target volume (CTV) receiving 95% and 100% of the prescribed dose. Homogeneity was measured using the sigma index of the PTV and CTV. Conformity was measured using the lesion coverage factor, healthy tissue conformity index, and the conformity number. Multivariate regression models were created to determine the relationship between these and T stage, risk status, androgen deprivation therapy use, treatment center, planning system, and treatment date. Results: The largest discriminatory measurements of coverage, homogeneity, and conformity were the PTV V{sub 95%}, PTV sigma index, and conformity number. The mean PTV V{sub 95%} was 92.5% (95% confidence interval, 91.3-93.7%). The mean PTV sigma index was 2.10 Gy (95% confidence interval, 1.90-2.20). The mean conformity number was 0.78 (95% confidence interval, 0.76-0.79). The treatment center independently influenced the coverage, homogeneity, and conformity (all p < .0001). The planning system independently influenced homogeneity (p = .038) and conformity (p = .021). The treatment date independently influenced the PTV V{sub 95%} only, with it being better at the start (p = .013). Risk status, T stage, and the use of androgen deprivation therapy did not influence any aspect of plan quality. Conclusion: Our study has benchmarked measures

μ-synthesis for the coupled mass benchmark problem

DEFF Research Database (Denmark)

Niemann, Hans Henrik; Stoustrup, J.; Tøffner-Clausen, S.

1997-01-01

A robust controller design for the coupled mass benchmark problem is presented in this paper. The applied design method is based on a modified D-K iteration, i.e. μ-synthesis which take care of mixed real and complex perturbations sets. This μ-synthesis method for mixed perturbation sets is a str......A robust controller design for the coupled mass benchmark problem is presented in this paper. The applied design method is based on a modified D-K iteration, i.e. μ-synthesis which take care of mixed real and complex perturbations sets. This μ-synthesis method for mixed perturbation sets...

KAERI results for BN600 full MOX benchmark (Phase 4)

International Nuclear Information System (INIS)

Lee, Kibog Lee

2003-01-01

The purpose of this document is to report the results of KAERI's calculation for the Phase-4 of BN-600 full MOX fueled core benchmark analyses according to the RCM report of IAEA CRP Action on U pdated Codes and Methods to Reduce the Calculational Uncertainties of the LMFR Reactivity Effects. T he BN-600 full MOX core model is based on the specification in the document, F ull MOX Model (Phase4. doc ) . This document addresses the calculational methods employed in the benchmark analyses and benchmark results carried out by KAERI

An automated protocol for performance benchmarking a widefield fluorescence microscope.

Science.gov (United States)

Halter, Michael; Bier, Elianna; DeRose, Paul C; Cooksey, Gregory A; Choquette, Steven J; Plant, Anne L; Elliott, John T

2014-11-01

Widefield fluorescence microscopy is a highly used tool for visually assessing biological samples and for quantifying cell responses. Despite its widespread use in high content analysis and other imaging applications, few published methods exist for evaluating and benchmarking the analytical performance of a microscope. Easy-to-use benchmarking methods would facilitate the use of fluorescence imaging as a quantitative analytical tool in research applications, and would aid the determination of instrumental method validation for commercial product development applications. We describe and evaluate an automated method to characterize a fluorescence imaging system's performance by benchmarking the detection threshold, saturation, and linear dynamic range to a reference material. The benchmarking procedure is demonstrated using two different materials as the reference material, uranyl-ion-doped glass and Schott 475 GG filter glass. Both are suitable candidate reference materials that are homogeneously fluorescent and highly photostable, and the Schott 475 GG filter glass is currently commercially available. In addition to benchmarking the analytical performance, we also demonstrate that the reference materials provide for accurate day to day intensity calibration. Published 2014 Wiley Periodicals Inc. Published 2014 Wiley Periodicals Inc. This article is a US government work and, as such, is in the public domain in the United States of America.

Utilizing benchmark data from the ANL-ZPR diagnostic cores program

International Nuclear Information System (INIS)

Schaefer, R. W.; McKnight, R. D.

2000-01-01

The support of the criticality safety community is allowing the production of benchmark descriptions of several assemblies from the ZPR Diagnostic Cores Program. The assemblies have high sensitivities to nuclear data for a few isotopes. This can highlight limitations in nuclear data for selected nuclides or in standard methods used to treat these data. The present work extends the use of the simplified model of the U9 benchmark assembly beyond the validation of k eff . Further simplifications have been made to produce a data testing benchmark in the style of the standard CSEWG benchmark specifications. Calculations for this data testing benchmark are compared to results obtained with more detailed models and methods to determine their biases. These biases or corrections factors can then be applied in the use of the less refined methods and models. Data testing results using Versions IV, V, and VI of the ENDF/B nuclear data are presented for k eff , f 28 /f 25 , c 28 /f 25 , and β eff . These limited results demonstrate the importance of studying other integral parameters in addition to k eff in trying to improve nuclear data and methods and the importance of accounting for methods and/or modeling biases when using data testing results to infer the quality of the nuclear data files

The role of benchmarking for yardstick competition

International Nuclear Information System (INIS)

Burns, Phil; Jenkins, Cloda; Riechmann, Christoph

2005-01-01

With the increasing interest in yardstick regulation, there is a need to understand the most appropriate method for realigning tariffs at the outset. Benchmarking is the tool used for such realignment and is therefore a necessary first-step in the implementation of yardstick competition. A number of concerns have been raised about the application of benchmarking, making some practitioners reluctant to move towards yardstick based regimes. We assess five of the key concerns often discussed and find that, in general, these are not as great as perceived. The assessment is based on economic principles and experiences with applying benchmarking to regulated sectors, e.g. in the electricity and water industries in the UK, The Netherlands, Austria and Germany in recent years. The aim is to demonstrate that clarity on the role of benchmarking reduces the concern about its application in different regulatory regimes. We find that benchmarking can be used in regulatory settlements, although the range of possible benchmarking approaches that are appropriate will be small for any individual regulatory question. Benchmarking is feasible as total cost measures and environmental factors are better defined in practice than is commonly appreciated and collusion is unlikely to occur in environments with more than 2 or 3 firms (where shareholders have a role in monitoring and rewarding performance). Furthermore, any concern about companies under-recovering costs is a matter to be determined through the regulatory settlement and does not affect the case for using benchmarking as part of that settlement. (author)

Benchmarking semantic web technology

CERN Document Server

García-Castro, R

2009-01-01

This book addresses the problem of benchmarking Semantic Web Technologies; first, from a methodological point of view, proposing a general methodology to follow in benchmarking activities over Semantic Web Technologies and, second, from a practical point of view, presenting two international benchmarking activities that involved benchmarking the interoperability of Semantic Web technologies using RDF(S) as the interchange language in one activity and OWL in the other.The book presents in detail how the different resources needed for these interoperability benchmarking activities were defined:

Tourism Destination Benchmarking: Evaluation and Selection of the Benchmarking Partners

Directory of Open Access Journals (Sweden)

Luštický Martin

2012-03-01

Full Text Available Tourism development has an irreplaceable role in regional policy of almost all countries. This is due to its undeniable benefits for the local population with regards to the economic, social and environmental sphere. Tourist destinations compete for visitors at tourism market and subsequently get into a relatively sharp competitive struggle. The main goal of regional governments and destination management institutions is to succeed in this struggle by increasing the competitiveness of their destination. The quality of strategic planning and final strategies is a key factor of competitiveness. Even though the tourism sector is not the typical field where the benchmarking methods are widely used, such approaches could be successfully applied. The paper focuses on key phases of the benchmarking process which lies in the search for suitable referencing partners. The partners are consequently selected to meet general requirements to ensure the quality if strategies. Following from this, some specific characteristics are developed according to the SMART approach. The paper tests this procedure with an expert evaluation of eight selected regional tourism strategies of regions in the Czech Republic, Slovakia and Great Britain. In this way it validates the selected criteria in the frame of the international environment. Hence, it makes it possible to find strengths and weaknesses of selected strategies and at the same time facilitates the discovery of suitable benchmarking partners.

Decoys Selection in Benchmarking Datasets: Overview and Perspectives

Science.gov (United States)

Réau, Manon; Langenfeld, Florent; Zagury, Jean-François; Lagarde, Nathalie; Montes, Matthieu

2018-01-01

Virtual Screening (VS) is designed to prospectively help identifying potential hits, i.e., compounds capable of interacting with a given target and potentially modulate its activity, out of large compound collections. Among the variety of methodologies, it is crucial to select the protocol that is the most adapted to the query/target system under study and that yields the most reliable output. To this aim, the performance of VS methods is commonly evaluated and compared by computing their ability to retrieve active compounds in benchmarking datasets. The benchmarking datasets contain a subset of known active compounds together with a subset of decoys, i.e., assumed non-active molecules. The composition of both the active and the decoy compounds subsets is critical to limit the biases in the evaluation of the VS methods. In this review, we focus on the selection of decoy compounds that has considerably changed over the years, from randomly selected compounds to highly customized or experimentally validated negative compounds. We first outline the evolution of decoys selection in benchmarking databases as well as current benchmarking databases that tend to minimize the introduction of biases, and secondly, we propose recommendations for the selection and the design of benchmarking datasets. PMID:29416509

Developing a benchmark for emotional analysis of music.

Science.gov (United States)

Aljanaki, Anna; Yang, Yi-Hsuan; Soleymani, Mohammad

2017-01-01

Music emotion recognition (MER) field rapidly expanded in the last decade. Many new methods and new audio features are developed to improve the performance of MER algorithms. However, it is very difficult to compare the performance of the new methods because of the data representation diversity and scarcity of publicly available data. In this paper, we address these problems by creating a data set and a benchmark for MER. The data set that we release, a MediaEval Database for Emotional Analysis in Music (DEAM), is the largest available data set of dynamic annotations (valence and arousal annotations for 1,802 songs and song excerpts licensed under Creative Commons with 2Hz time resolution). Using DEAM, we organized the 'Emotion in Music' task at MediaEval Multimedia Evaluation Campaign from 2013 to 2015. The benchmark attracted, in total, 21 active teams to participate in the challenge. We analyze the results of the benchmark: the winning algorithms and feature-sets. We also describe the design of the benchmark, the evaluation procedures and the data cleaning and transformations that we suggest. The results from the benchmark suggest that the recurrent neural network based approaches combined with large feature-sets work best for dynamic MER.

Benchmarking Sustainability Practices Use throughout Industrial Construction Project Delivery

Directory of Open Access Journals (Sweden)

Sungmin Yun

2017-06-01

Full Text Available Despite the efforts for sustainability studies in building and infrastructure construction, the sustainability issues in industrial construction remain understudied. Further, few studies evaluate sustainability and benchmark sustainability issues in industrial construction from a management perspective. This study presents a phase-based benchmarking framework for evaluating sustainability practices use focusing on industrial facilities project. Based on the framework, this study quantifies and assesses sustainability practices use, and further sorts the results by project phase and major project characteristics, including project type, project nature, and project delivery method. The results show that sustainability practices were implemented higher in the construction and startup phases relative to other phases, with a very broad range. An assessment by project type and project nature showed significant differences in sustainability practices use, but no significant difference in practices use by project delivery method. This study contributes to providing a benchmarking method for sustainability practices in industrial facilities projects at the project phase level. This study also discusses and provides an application of phase-based benchmarking for sustainability in industrial construction.

RUNE benchmarks

DEFF Research Database (Denmark)

Peña, Alfredo

This report contains the description of a number of benchmarks with the purpose of evaluating flow models for near-shore wind resource estimation. The benchmarks are designed based on the comprehensive database of observations that the RUNE coastal experiment established from onshore lidar...

MCNP neutron benchmarks

International Nuclear Information System (INIS)

Hendricks, J.S.; Whalen, D.J.; Cardon, D.A.; Uhle, J.L.

1991-01-01

Over 50 neutron benchmark calculations have recently been completed as part of an ongoing program to validate the MCNP Monte Carlo radiation transport code. The new and significant aspects of this work are as follows: These calculations are the first attempt at a validation program for MCNP and the first official benchmarking of version 4 of the code. We believe the chosen set of benchmarks is a comprehensive set that may be useful for benchmarking other radiation transport codes and data libraries. These calculations provide insight into how well neutron transport calculations can be expected to model a wide variety of problems

Strategic behaviour under regulatory benchmarking

Energy Technology Data Exchange (ETDEWEB)

Jamasb, T. [Cambridge Univ. (United Kingdom). Dept. of Applied Economics; Nillesen, P. [NUON NV (Netherlands); Pollitt, M. [Cambridge Univ. (United Kingdom). Judge Inst. of Management

2004-09-01

In order to improve the efficiency of electricity distribution networks, some regulators have adopted incentive regulation schemes that rely on performance benchmarking. Although regulation benchmarking can influence the ''regulation game,'' the subject has received limited attention. This paper discusses how strategic behaviour can result in inefficient behaviour by firms. We then use the Data Envelopment Analysis (DEA) method with US utility data to examine implications of illustrative cases of strategic behaviour reported by regulators. The results show that gaming can have significant effects on the measured performance and profitability of firms. (author)

3-D neutron transport benchmarks

International Nuclear Information System (INIS)

Takeda, T.; Ikeda, H.

1991-03-01

A set of 3-D neutron transport benchmark problems proposed by the Osaka University to NEACRP in 1988 has been calculated by many participants and the corresponding results are summarized in this report. The results of K eff , control rod worth and region-averaged fluxes for the four proposed core models, calculated by using various 3-D transport codes are compared and discussed. The calculational methods used were: Monte Carlo, Discrete Ordinates (Sn), Spherical Harmonics (Pn), Nodal Transport and others. The solutions of the four core models are quite useful as benchmarks for checking the validity of 3-D neutron transport codes

International handbook of evaluated criticality safety benchmark experiments

International Nuclear Information System (INIS)

2010-01-01

The Criticality Safety Benchmark Evaluation Project (CSBEP) was initiated in October of 1992 by the United States Department of Energy. The project quickly became an international effort as scientists from other interested countries became involved. The International Criticality Safety Benchmark Evaluation Project (ICSBEP) became an official activity of the Organization for Economic Cooperation and Development - Nuclear Energy Agency (OECD-NEA) in 1995. This handbook contains criticality safety benchmark specifications that have been derived from experiments performed at various nuclear critical facilities around the world. The benchmark specifications are intended for use by criticality safety engineers to validate calculational techniques used to establish minimum subcritical margins for operations with fissile material and to determine criticality alarm requirement and placement. Many of the specifications are also useful for nuclear data testing. Example calculations are presented; however, these calculations do not constitute a validation of the codes or cross section data. The evaluated criticality safety benchmark data are given in nine volumes. These volumes span over 55,000 pages and contain 516 evaluations with benchmark specifications for 4,405 critical, near critical, or subcritical configurations, 24 criticality alarm placement / shielding configurations with multiple dose points for each, and 200 configurations that have been categorized as fundamental physics measurements that are relevant to criticality safety applications. Experiments that are found unacceptable for use as criticality safety benchmark experiments are discussed in these evaluations; however, benchmark specifications are not derived for such experiments (in some cases models are provided in an appendix). Approximately 770 experimental configurations are categorized as unacceptable for use as criticality safety benchmark experiments. Additional evaluations are in progress and will be

RESULTS OF ANALYSIS OF BENCHMARKING METHODS OF INNOVATION SYSTEMS ASSESSMENT IN ACCORDANCE WITH AIMS OF SUSTAINABLE DEVELOPMENT OF SOCIETY

Directory of Open Access Journals (Sweden)

A. Vylegzhanina

2016-01-01

Full Text Available In this work, we introduce results of comparative analysis of international ratings indexes of innovation systems for their compliance with purposes of sustainable development. Purpose of this research is defining requirements to benchmarking methods of assessing national or regional innovation systems and compare them basing on assumption, that innovation system is aligned with sustainable development concept. Analysis of goal sets and concepts, which underlie observed international composite innovation indexes, comparison of their metrics and calculation techniques, allowed us to reveal opportunities and limitations of using these methods in frames of sustainable development concept. We formulated targets of innovation development on the base of innovation priorities of sustainable socio-economic development. Using comparative analysis of indexes with these targets, we revealed two methods of assessing innovation systems, maximally connected with goals of sustainable development. Nevertheless, today no any benchmarking method, which meets need of innovation systems assessing in compliance with sustainable development concept to a sufficient extent. We suggested practical directions of developing methods, assessing innovation systems in compliance with goals of societal sustainable development.

Dose escalation methods in phase I cancer clinical trials.

Science.gov (United States)

Le Tourneau, Christophe; Lee, J Jack; Siu, Lillian L

2009-05-20

Phase I clinical trials are an essential step in the development of anticancer drugs. The main goal of these studies is to establish the recommended dose and/or schedule of new drugs or drug combinations for phase II trials. The guiding principle for dose escalation in phase I trials is to avoid exposing too many patients to subtherapeutic doses while preserving safety and maintaining rapid accrual. Here we review dose escalation methods for phase I trials, including the rule-based and model-based dose escalation methods that have been developed to evaluate new anticancer agents. Toxicity has traditionally been the primary endpoint for phase I trials involving cytotoxic agents. However, with the emergence of molecularly targeted anticancer agents, potential alternative endpoints to delineate optimal biological activity, such as plasma drug concentration and target inhibition in tumor or surrogate tissues, have been proposed along with new trial designs. We also describe specific methods for drug combinations as well as methods that use a time-to-event endpoint or both toxicity and efficacy as endpoints. Finally, we present the advantages and drawbacks of the various dose escalation methods and discuss specific applications of the methods in developmental oncotherapeutics.

How to benchmark methods for structure-based virtual screening of large compound libraries.

Science.gov (United States)

Christofferson, Andrew J; Huang, Niu

2012-01-01

Structure-based virtual screening is a useful computational technique for ligand discovery. To systematically evaluate different docking approaches, it is important to have a consistent benchmarking protocol that is both relevant and unbiased. Here, we describe the designing of a benchmarking data set for docking screen assessment, a standard docking screening process, and the analysis and presentation of the enrichment of annotated ligands among a background decoy database.

Three-dimensional RAMA fluence methodology benchmarking

International Nuclear Information System (INIS)

Baker, S. P.; Carter, R. G.; Watkins, K. E.; Jones, D. B.

2004-01-01

This paper describes the benchmarking of the RAMA Fluence Methodology software, that has been performed in accordance with U. S. Nuclear Regulatory Commission Regulatory Guide 1.190. The RAMA Fluence Methodology has been developed by TransWare Enterprises Inc. through funding provided by the Electric Power Research Inst., Inc. (EPRI) and the Boiling Water Reactor Vessel and Internals Project (BWRVIP). The purpose of the software is to provide an accurate method for calculating neutron fluence in BWR pressure vessels and internal components. The Methodology incorporates a three-dimensional deterministic transport solution with flexible arbitrary geometry representation of reactor system components, previously available only with Monte Carlo solution techniques. Benchmarking was performed on measurements obtained from three standard benchmark problems which include the Pool Criticality Assembly (PCA), VENUS-3, and H. B. Robinson Unit 2 benchmarks, and on flux wire measurements obtained from two BWR nuclear plants. The calculated to measured (C/M) ratios range from 0.93 to 1.04 demonstrating the accuracy of the RAMA Fluence Methodology in predicting neutron flux, fluence, and dosimetry activation. (authors)

Radiation Detection Computational Benchmark Scenarios

Energy Technology Data Exchange (ETDEWEB)

Shaver, Mark W.; Casella, Andrew M.; Wittman, Richard S.; McDonald, Ben S.

2013-09-24

Modeling forms an important component of radiation detection development, allowing for testing of new detector designs, evaluation of existing equipment against a wide variety of potential threat sources, and assessing operation performance of radiation detection systems. This can, however, result in large and complex scenarios which are time consuming to model. A variety of approaches to radiation transport modeling exist with complementary strengths and weaknesses for different problems. This variety of approaches, and the development of promising new tools (such as ORNL’s ADVANTG) which combine benefits of multiple approaches, illustrates the need for a means of evaluating or comparing different techniques for radiation detection problems. This report presents a set of 9 benchmark problems for comparing different types of radiation transport calculations, identifying appropriate tools for classes of problems, and testing and guiding the development of new methods. The benchmarks were drawn primarily from existing or previous calculations with a preference for scenarios which include experimental data, or otherwise have results with a high level of confidence, are non-sensitive, and represent problem sets of interest to NA-22. From a technical perspective, the benchmarks were chosen to span a range of difficulty and to include gamma transport, neutron transport, or both and represent different important physical processes and a range of sensitivity to angular or energy fidelity. Following benchmark identification, existing information about geometry, measurements, and previous calculations were assembled. Monte Carlo results (MCNP decks) were reviewed or created and re-run in order to attain accurate computational times and to verify agreement with experimental data, when present. Benchmark information was then conveyed to ORNL in order to guide testing and development of hybrid calculations. The results of those ADVANTG calculations were then sent to PNNL for

Benchmark referencing of neutron dosimetry measurements

International Nuclear Information System (INIS)

Eisenhauer, C.M.; Grundl, J.A.; Gilliam, D.M.; McGarry, E.D.; Spiegel, V.

1980-01-01

The concept of benchmark referencing involves interpretation of dosimetry measurements in applied neutron fields in terms of similar measurements in benchmark fields whose neutron spectra and intensity are well known. The main advantage of benchmark referencing is that it minimizes or eliminates many types of experimental uncertainties such as those associated with absolute detection efficiencies and cross sections. In this paper we consider the cavity external to the pressure vessel of a power reactor as an example of an applied field. The pressure vessel cavity is an accessible location for exploratory dosimetry measurements aimed at understanding embrittlement of pressure vessel steel. Comparisons with calculated predictions of neutron fluence and spectra in the cavity provide a valuable check of the computational methods used to estimate pressure vessel safety margins for pressure vessel lifetimes

Benchmarking strategies for measuring the quality of healthcare: problems and prospects.

Science.gov (United States)

Lovaglio, Pietro Giorgio

2012-01-01

Over the last few years, increasing attention has been directed toward the problems inherent to measuring the quality of healthcare and implementing benchmarking strategies. Besides offering accreditation and certification processes, recent approaches measure the performance of healthcare institutions in order to evaluate their effectiveness, defined as the capacity to provide treatment that modifies and improves the patient's state of health. This paper, dealing with hospital effectiveness, focuses on research methods for effectiveness analyses within a strategy comparing different healthcare institutions. The paper, after having introduced readers to the principle debates on benchmarking strategies, which depend on the perspective and type of indicators used, focuses on the methodological problems related to performing consistent benchmarking analyses. Particularly, statistical methods suitable for controlling case-mix, analyzing aggregate data, rare events, and continuous outcomes measured with error are examined. Specific challenges of benchmarking strategies, such as the risk of risk adjustment (case-mix fallacy, underreporting, risk of comparing noncomparable hospitals), selection bias, and possible strategies for the development of consistent benchmarking analyses, are discussed. Finally, to demonstrate the feasibility of the illustrated benchmarking strategies, an application focused on determining regional benchmarks for patient satisfaction (using 2009 Lombardy Region Patient Satisfaction Questionnaire) is proposed.

Benchmarking and Performance Management

Directory of Open Access Journals (Sweden)

Adrian TANTAU

2010-12-01

Full Text Available The relevance of the chosen topic is explained by the meaning of the firm efficiency concept - the firm efficiency means the revealed performance (how well the firm performs in the actual market environment given the basic characteristics of the firms and their markets that are expected to drive their profitability (firm size, market power etc.. This complex and relative performance could be due to such things as product innovation, management quality, work organization, some other factors can be a cause even if they are not directly observed by the researcher. The critical need for the management individuals/group to continuously improve their firm/company’s efficiency and effectiveness, the need for the managers to know which are the success factors and the competitiveness determinants determine consequently, what performance measures are most critical in determining their firm’s overall success. Benchmarking, when done properly, can accurately identify both successful companies and the underlying reasons for their success. Innovation and benchmarking firm level performance are critical interdependent activities. Firm level variables, used to infer performance, are often interdependent due to operational reasons. Hence, the managers need to take the dependencies among these variables into account when forecasting and benchmarking performance. This paper studies firm level performance using financial ratio and other type of profitability measures. It uses econometric models to describe and then propose a method to forecast and benchmark performance.

Accuracy of effective dose estimation in personal dosimetry: a comparison between single-badge and double-badge methods and the MOSFET method.

Science.gov (United States)

Januzis, Natalie; Belley, Matthew D; Nguyen, Giao; Toncheva, Greta; Lowry, Carolyn; Miller, Michael J; Smith, Tony P; Yoshizumi, Terry T

2014-05-01

The purpose of this study was three-fold: (1) to measure the transmission properties of various lead shielding materials, (2) to benchmark the accuracy of commercial film badge readings, and (3) to compare the accuracy of effective dose (ED) conversion factors (CF) of the U.S. Nuclear Regulatory Commission methods to the MOSFET method. The transmission properties of lead aprons and the accuracy of film badges were studied using an ion chamber and monitor. ED was determined using an adult male anthropomorphic phantom that was loaded with 20 diagnostic MOSFET detectors and scanned with a whole body CT protocol at 80, 100, and 120 kVp. One commercial film badge was placed at the collar and one at the waist. Individual organ doses and waist badge readings were corrected for lead apron attenuation. ED was computed using ICRP 103 tissue weighting factors, and ED CFs were calculated by taking the ratio of ED and badge reading. The measured single badge CFs were 0.01 (±14.9%), 0.02 (±9.49%), and 0.04 (±15.7%) for 80, 100, and 120 kVp, respectively. Current regulatory ED CF for the single badge method is 0.3; for the double-badge system, they are 0.04 (collar) and 1.5 (under lead apron at the waist). The double-badge system provides a better coefficient for the collar at 0.04; however, exposure readings under the apron are usually negligible to zero. Based on these findings, the authors recommend the use of ED CF of 0.01 for the single badge system from 80 kVp (effective energy 50.4 keV) data.

Methods to stimulate national and sub-national benchmarking through international health system performance comparisons: a Canadian approach.

Science.gov (United States)

Veillard, Jeremy; Moses McKeag, Alexandra; Tipper, Brenda; Krylova, Olga; Reason, Ben

2013-09-01

This paper presents, discusses and evaluates methods used by the Canadian Institute for Health Information to present health system performance international comparisons in ways that facilitate their understanding by the public and health system policy-makers and can stimulate performance benchmarking. We used statistical techniques to normalize the results and present them on a standardized scale facilitating understanding of results. We compared results to the OECD average, and to benchmarks. We also applied various data quality rules to ensure the validity of results. In order to evaluate the impact of the public release of these results, we used quantitative and qualitative methods and documented other types of impact. We were able to present results for performance indicators and dimensions at national and sub-national levels; develop performance profiles for each Canadian province; and show pan-Canadian performance patterns for specific performance indicators. The results attracted significant media attention at national level and reactions from various stakeholders. Other impacts such as requests for additional analysis and improvement in data timeliness were observed. The methods used seemed attractive to various audiences in the Canadian context and achieved the objectives originally defined. These methods could be refined and applied in different contexts. Copyright © 2013 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Benchmark selection

DEFF Research Database (Denmark)

Hougaard, Jens Leth; Tvede, Mich

2002-01-01

Within a production theoretic framework, this paper considers an axiomatic approach to benchmark selection. It is shown that two simple and weak axioms; efficiency and comprehensive monotonicity characterize a natural family of benchmarks which typically becomes unique. Further axioms are added...... in order to obtain a unique selection...

Benchmark Comparison of Cloud Analytics Methods Applied to Earth Observations

Science.gov (United States)

Lynnes, Chris; Little, Mike; Huang, Thomas; Jacob, Joseph; Yang, Phil; Kuo, Kwo-Sen

2016-01-01

Cloud computing has the potential to bring high performance computing capabilities to the average science researcher. However, in order to take full advantage of cloud capabilities, the science data used in the analysis must often be reorganized. This typically involves sharding the data across multiple nodes to enable relatively fine-grained parallelism. This can be either via cloud-based file systems or cloud-enabled databases such as Cassandra, Rasdaman or SciDB. Since storing an extra copy of data leads to increased cost and data management complexity, NASA is interested in determining the benefits and costs of various cloud analytics methods for real Earth Observation cases. Accordingly, NASA's Earth Science Technology Office and Earth Science Data and Information Systems project have teamed with cloud analytics practitioners to run a benchmark comparison on cloud analytics methods using the same input data and analysis algorithms. We have particularly looked at analysis algorithms that work over long time series, because these are particularly intractable for many Earth Observation datasets which typically store data with one or just a few time steps per file. This post will present side-by-side cost and performance results for several common Earth observation analysis operations.

Benchmark Comparison of Cloud Analytics Methods Applied to Earth Observations

Science.gov (United States)

Lynnes, C.; Little, M. M.; Huang, T.; Jacob, J. C.; Yang, C. P.; Kuo, K. S.

2016-12-01

Cloud computing has the potential to bring high performance computing capabilities to the average science researcher. However, in order to take full advantage of cloud capabilities, the science data used in the analysis must often be reorganized. This typically involves sharding the data across multiple nodes to enable relatively fine-grained parallelism. This can be either via cloud-based filesystems or cloud-enabled databases such as Cassandra, Rasdaman or SciDB. Since storing an extra copy of data leads to increased cost and data management complexity, NASA is interested in determining the benefits and costs of various cloud analytics methods for real Earth Observation cases. Accordingly, NASA's Earth Science Technology Office and Earth Science Data and Information Systems project have teamed with cloud analytics practitioners to run a benchmark comparison on cloud analytics methods using the same input data and analysis algorithms. We have particularly looked at analysis algorithms that work over long time series, because these are particularly intractable for many Earth Observation datasets which typically store data with one or just a few time steps per file. This post will present side-by-side cost and performance results for several common Earth observation analysis operations.

Simplified dose calculation method for mantle technique

International Nuclear Information System (INIS)

Scaff, L.A.M.

1984-01-01

A simplified dose calculation method for mantle technique is described. In the routine treatment of lymphom as using this technique, the daily doses at the midpoints at five anatomical regions are different because the thicknesses are not equal. (Author) [pt

Benchmarking school nursing practice: the North West Regional Benchmarking Group

OpenAIRE

Littler, Nadine; Mullen, Margaret; Beckett, Helen; Freshney, Alice; Pinder, Lynn

2016-01-01

It is essential that the quality of care is reviewed regularly through robust processes such as benchmarking to ensure all outcomes and resources are evidence-based so that children and young people’s needs are met effectively. This article provides an example of the use of benchmarking in school nursing practice. Benchmarking has been defined as a process for finding, adapting and applying best practices (Camp, 1994). This concept was first adopted in the 1970s ‘from industry where it was us...

Latent uncertainties of the precalculated track Monte Carlo method

Energy Technology Data Exchange (ETDEWEB)

Renaud, Marc-André; Seuntjens, Jan [Medical Physics Unit, McGill University, Montreal, Quebec H3G 1A4 (Canada); Roberge, David [Département de radio-oncologie, Centre Hospitalier de l’Université de Montréal, Montreal, Quebec H2L 4M1 (Canada)

2015-01-15

Purpose: While significant progress has been made in speeding up Monte Carlo (MC) dose calculation methods, they remain too time-consuming for the purpose of inverse planning. To achieve clinically usable calculation speeds, a precalculated Monte Carlo (PMC) algorithm for proton and electron transport was developed to run on graphics processing units (GPUs). The algorithm utilizes pregenerated particle track data from conventional MC codes for different materials such as water, bone, and lung to produce dose distributions in voxelized phantoms. While PMC methods have been described in the past, an explicit quantification of the latent uncertainty arising from the limited number of unique tracks in the pregenerated track bank is missing from the paper. With a proper uncertainty analysis, an optimal number of tracks in the pregenerated track bank can be selected for a desired dose calculation uncertainty. Methods: Particle tracks were pregenerated for electrons and protons using EGSnrc and GEANT4 and saved in a database. The PMC algorithm for track selection, rotation, and transport was implemented on the Compute Unified Device Architecture (CUDA) 4.0 programming framework. PMC dose distributions were calculated in a variety of media and compared to benchmark dose distributions simulated from the corresponding general-purpose MC codes in the same conditions. A latent uncertainty metric was defined and analysis was performed by varying the pregenerated track bank size and the number of simulated primary particle histories and comparing dose values to a “ground truth” benchmark dose distribution calculated to 0.04% average uncertainty in voxels with dose greater than 20% of D{sub max}. Efficiency metrics were calculated against benchmark MC codes on a single CPU core with no variance reduction. Results: Dose distributions generated using PMC and benchmark MC codes were compared and found to be within 2% of each other in voxels with dose values greater than 20% of

Latent uncertainties of the precalculated track Monte Carlo method

International Nuclear Information System (INIS)

Renaud, Marc-André; Seuntjens, Jan; Roberge, David

2015-01-01

Purpose: While significant progress has been made in speeding up Monte Carlo (MC) dose calculation methods, they remain too time-consuming for the purpose of inverse planning. To achieve clinically usable calculation speeds, a precalculated Monte Carlo (PMC) algorithm for proton and electron transport was developed to run on graphics processing units (GPUs). The algorithm utilizes pregenerated particle track data from conventional MC codes for different materials such as water, bone, and lung to produce dose distributions in voxelized phantoms. While PMC methods have been described in the past, an explicit quantification of the latent uncertainty arising from the limited number of unique tracks in the pregenerated track bank is missing from the paper. With a proper uncertainty analysis, an optimal number of tracks in the pregenerated track bank can be selected for a desired dose calculation uncertainty. Methods: Particle tracks were pregenerated for electrons and protons using EGSnrc and GEANT4 and saved in a database. The PMC algorithm for track selection, rotation, and transport was implemented on the Compute Unified Device Architecture (CUDA) 4.0 programming framework. PMC dose distributions were calculated in a variety of media and compared to benchmark dose distributions simulated from the corresponding general-purpose MC codes in the same conditions. A latent uncertainty metric was defined and analysis was performed by varying the pregenerated track bank size and the number of simulated primary particle histories and comparing dose values to a “ground truth” benchmark dose distribution calculated to 0.04% average uncertainty in voxels with dose greater than 20% of D max . Efficiency metrics were calculated against benchmark MC codes on a single CPU core with no variance reduction. Results: Dose distributions generated using PMC and benchmark MC codes were compared and found to be within 2% of each other in voxels with dose values greater than 20% of the

A simplified 2D HTTR benchmark problem

International Nuclear Information System (INIS)

Zhang, Z.; Rahnema, F.; Pounders, J. M.; Zhang, D.; Ougouag, A.

2009-01-01

To access the accuracy of diffusion or transport methods for reactor calculations, it is desirable to create heterogeneous benchmark problems that are typical of relevant whole core configurations. In this paper we have created a numerical benchmark problem in 2D configuration typical of a high temperature gas cooled prismatic core. This problem was derived from the HTTR start-up experiment. For code-to-code verification, complex details of geometry and material specification of the physical experiments are not necessary. To this end, the benchmark problem presented here is derived by simplifications that remove the unnecessary details while retaining the heterogeneity and major physics properties from the neutronics viewpoint. Also included here is a six-group material (macroscopic) cross section library for the benchmark problem. This library was generated using the lattice depletion code HELIOS. Using this library, benchmark quality Monte Carlo solutions are provided for three different configurations (all-rods-in, partially-controlled and all-rods-out). The reference solutions include the core eigenvalue, block (assembly) averaged fuel pin fission density distributions, and absorption rate in absorbers (burnable poison and control rods). (authors)

International Handbook of Evaluated Criticality Safety Benchmark Experiments - ICSBEP (DVD), Version 2013

International Nuclear Information System (INIS)

2013-01-01

The Criticality Safety Benchmark Evaluation Project (CSBEP) was initiated in October of 1992 by the United States Department of Energy. The project quickly became an international effort as scientists from other interested countries became involved. The International Criticality Safety Benchmark Evaluation Project (ICSBEP) became an official activity of the Organisation for Economic Co-operation and Development (OECD) Nuclear Energy Agency (NEA) in 1995. This handbook contains criticality safety benchmark specifications that have been derived from experiments performed at various nuclear critical experiment facilities around the world. The benchmark specifications are intended for use by criticality safety engineers to validate calculational techniques used to establish minimum subcritical margins for operations with fissile material and to determine criticality alarm requirement and placement. Many of the specifications are also useful for nuclear data testing. Example calculations are presented; however, these calculations do not constitute a validation of the codes or cross section data. The evaluated criticality safety benchmark data are given in nine volumes. These volumes span nearly 66,000 pages and contain 558 evaluations with benchmark specifications for 4,798 critical, near critical or subcritical configurations, 24 criticality alarm placement/shielding configurations with multiple dose points for each and 200 configurations that have been categorised as fundamental physics measurements that are relevant to criticality safety applications. New to the Handbook are benchmark specifications for Critical, Bare, HEU(93.2)- Metal Sphere experiments referred to as ORSphere that were performed by a team of experimenters at Oak Ridge National Laboratory in the early 1970's. A photograph of this assembly is shown on the front cover

Benchmarking of a novel contactless characterisation method for micro thermoelectric modules (μTEMs)

International Nuclear Information System (INIS)

Hickey, S; Punch, J; Jeffers, N

2014-01-01

Significant challenges exist in the thermal control of Photonics Integrated Circuits (PICs) for use in optical communications. Increasing component density coupled with greater functionality is leading to higher device-level heat fluxes, stretching the capabilities of conventional cooling methods using thermoelectric modules (TEMs). A tailored thermal control solution incorporating micro thermoelectric modules (μTEMs) to individually address hotspots within PICs could provide an energy efficient alternative to existing control methods. Performance characterisation is required to establish the suitability of commercially-available μTEMs for the operating conditions in current and next generation PICs. The objective of this paper is to outline a novel method for the characterisation of thermoelectric modules (TEMs), which utilises infra-red (IR) heat transfer and temperature measurement to obviate the need for mechanical stress on the upper surface of low compression tolerance (∼0.5N) μTEMs. The method is benchmarked using a commercially-available macro scale TEM, comparing experimental data to the manufacturer's performance data sheet.

Benchmarking of a novel contactless characterisation method for micro thermoelectric modules (μTEMs)

Science.gov (United States)

Hickey, S.; Punch, J.; Jeffers, N.

2014-07-01

Significant challenges exist in the thermal control of Photonics Integrated Circuits (PICs) for use in optical communications. Increasing component density coupled with greater functionality is leading to higher device-level heat fluxes, stretching the capabilities of conventional cooling methods using thermoelectric modules (TEMs). A tailored thermal control solution incorporating micro thermoelectric modules (μTEMs) to individually address hotspots within PICs could provide an energy efficient alternative to existing control methods. Performance characterisation is required to establish the suitability of commercially-available μTEMs for the operating conditions in current and next generation PICs. The objective of this paper is to outline a novel method for the characterisation of thermoelectric modules (TEMs), which utilises infra-red (IR) heat transfer and temperature measurement to obviate the need for mechanical stress on the upper surface of low compression tolerance (~0.5N) μTEMs. The method is benchmarked using a commercially-available macro scale TEM, comparing experimental data to the manufacturer's performance data sheet.

Benchmarking Danish Vocational Education and Training Programmes

DEFF Research Database (Denmark)

Bogetoft, Peter; Wittrup, Jesper

This study paper discusses methods whereby Danish vocational education and training colleges can be benchmarked, and presents results from a number of models. It is conceptually complicated to benchmark vocational colleges, as the various colleges in Denmark offer a wide range of course programmes...... attempt to summarise the various effects that the colleges have in two relevant figures, namely retention rates of students and employment rates among students who have completed training programmes....

Reactor group constants and benchmark test

Energy Technology Data Exchange (ETDEWEB)

Takano, Hideki [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

2001-08-01

The evaluated nuclear data files such as JENDL, ENDF/B-VI and JEF-2 are validated by analyzing critical mock-up experiments for various type reactors and assessing applicability for nuclear characteristics such as criticality, reaction rates, reactivities, etc. This is called Benchmark Testing. In the nuclear calculations, the diffusion and transport codes use the group constant library which is generated by processing the nuclear data files. In this paper, the calculation methods of the reactor group constants and benchmark test are described. Finally, a new group constants scheme is proposed. (author)

Interactive benchmarking

DEFF Research Database (Denmark)

Lawson, Lartey; Nielsen, Kurt

2005-01-01

We discuss individual learning by interactive benchmarking using stochastic frontier models. The interactions allow the user to tailor the performance evaluation to preferences and explore alternative improvement strategies by selecting and searching the different frontiers using directional...... in the suggested benchmarking tool. The study investigates how different characteristics on dairy farms influences the technical efficiency....

Manual method for dose calculation in gynecologic brachytherapy

International Nuclear Information System (INIS)

Vianello, Elizabeth A.; Almeida, Carlos E. de; Biaggio, Maria F. de

1998-01-01

This paper describes a manual method for dose calculation in brachytherapy of gynecological tumors, which allows the calculation of the doses at any plane or point of clinical interest. This method uses basic principles of vectorial algebra and the simulating orthogonal films taken from the patient with the applicators and dummy sources in place. The results obtained with method were compared with the values calculated with the values calculated with the treatment planning system model Theraplan and the agreement was better than 5% in most cases. The critical points associated with the final accuracy of the proposed method is related to the quality of the image and the appropriate selection of the magnification factors. This method is strongly recommended to the radiation oncology centers where are no treatment planning systems available and the dose calculations are manually done. (author)

Benchmarking Strategies for Measuring the Quality of Healthcare: Problems and Prospects

Science.gov (United States)

Lovaglio, Pietro Giorgio

2012-01-01

Over the last few years, increasing attention has been directed toward the problems inherent to measuring the quality of healthcare and implementing benchmarking strategies. Besides offering accreditation and certification processes, recent approaches measure the performance of healthcare institutions in order to evaluate their effectiveness, defined as the capacity to provide treatment that modifies and improves the patient's state of health. This paper, dealing with hospital effectiveness, focuses on research methods for effectiveness analyses within a strategy comparing different healthcare institutions. The paper, after having introduced readers to the principle debates on benchmarking strategies, which depend on the perspective and type of indicators used, focuses on the methodological problems related to performing consistent benchmarking analyses. Particularly, statistical methods suitable for controlling case-mix, analyzing aggregate data, rare events, and continuous outcomes measured with error are examined. Specific challenges of benchmarking strategies, such as the risk of risk adjustment (case-mix fallacy, underreporting, risk of comparing noncomparable hospitals), selection bias, and possible strategies for the development of consistent benchmarking analyses, are discussed. Finally, to demonstrate the feasibility of the illustrated benchmarking strategies, an application focused on determining regional benchmarks for patient satisfaction (using 2009 Lombardy Region Patient Satisfaction Questionnaire) is proposed. PMID:22666140

Derivation of hazardous doses for amphibians acutely exposed to ionising radiation

International Nuclear Information System (INIS)

Fuma, Shoichi; Watanabe, Yoshito; Kawaguchi, Isao; Takata, Toshitaro; Kubota, Yoshihisa; Ban-nai, Tadaaki; Yoshida, Satoshi

2012-01-01

Derivation of effect benchmark values for each taxonomic group, which has been difficult due to lack of experimental effects data, is required for more adequate protection of the environment from ionising radiation. Estimation of effects doses from nuclear DNA mass and subsequent species sensitivity distribution (SSD) analysis were proposed as a method for such a derivation in acute irradiation situations for assumed nuclear accident scenarios. As a case study, 5% hazardous doses (HD 5 s), at which only 5% of species are acutely affected at 50% or higher lethality, were estimated on a global scale. After nuclear DNA mass data were obtained from a database, 50% lethal doses (LD 50 s) for 4.8 and 36% of the global Anura and Caudata species, respectively, were estimated by correlative equations between nuclear DNA mass and LD 50 s. Differences between estimated and experimental LD 50 s were within a factor of three. The HD 5 s obtained by the SSD analysis of these estimated LD 50 s data were 5.0 and 3.1 Gy for Anura and Caudata, respectively. This approach was also applied to the derivation of regional HD 5 s. The respective HD 5 s were 6.5 and 3.2 Gy for Anura and Caudata inhabiting Japan. This HD 5 value for the Japanese Anura was significantly higher than the global value, while Caudata had no significant difference in global and Japanese HD 5 s. These results suggest that this approach is also useful for derivation of regional benchmark values, some of which are likely different from the global values. - Highlights: ► A possible method was proposed for derivation of an effect benchmark value for each taxonomic group. ► 50% lethal doses were estimated from nuclear DNA mass in amphibian species. ► 5% hazardous doses (HD 5 s) were estimated by species sensitivity distribution. ► Respective HD 5 s were 5.0 and 3.1 Gy for Anura and Caudata globally. ► Respective HD 5 s were 6.5 and 3.2 Gy for Anura and Caudata inhabiting Japan.

An efficient dose-compensation method for proximity effect correction

International Nuclear Information System (INIS)

Wang Ying; Han Weihua; Yang Xiang; Zhang Yang; Yang Fuhua; Zhang Renping

2010-01-01

A novel simple dose-compensation method is developed for proximity effect correction in electron-beam lithography. The sizes of exposed patterns depend on dose factors while other exposure parameters (including accelerate voltage, resist thickness, exposing step size, substrate material, and so on) remain constant. This method is based on two reasonable assumptions in the evaluation of the compensated dose factor: one is that the relation between dose factors and circle-diameters is linear in the range under consideration; the other is that the compensated dose factor is only affected by the nearest neighbors for simplicity. Four-layer-hexagon photonic crystal structures were fabricated as test patterns to demonstrate this method. Compared to the uncorrected structures, the homogeneity of the corrected hole-size in photonic crystal structures was clearly improved. (semiconductor technology)

Bacterial whole genome-based phylogeny: construction of a new benchmarking dataset and assessment of some existing methods.

Science.gov (United States)

Ahrenfeldt, Johanne; Skaarup, Carina; Hasman, Henrik; Pedersen, Anders Gorm; Aarestrup, Frank Møller; Lund, Ole

2017-01-05

Whole genome sequencing (WGS) is increasingly used in diagnostics and surveillance of infectious diseases. A major application for WGS is to use the data for identifying outbreak clusters, and there is therefore a need for methods that can accurately and efficiently infer phylogenies from sequencing reads. In the present study we describe a new dataset that we have created for the purpose of benchmarking such WGS-based methods for epidemiological data, and also present an analysis where we use the data to compare the performance of some current methods. Our aim was to create a benchmark data set that mimics sequencing data of the sort that might be collected during an outbreak of an infectious disease. This was achieved by letting an E. coli hypermutator strain grow in the lab for 8 consecutive days, each day splitting the culture in two while also collecting samples for sequencing. The result is a data set consisting of 101 whole genome sequences with known phylogenetic relationship. Among the sequenced samples 51 correspond to internal nodes in the phylogeny because they are ancestral, while the remaining 50 correspond to leaves. We also used the newly created data set to compare three different online available methods that infer phylogenies from whole-genome sequencing reads: NDtree, CSI Phylogeny and REALPHY. One complication when comparing the output of these methods with the known phylogeny is that phylogenetic methods typically build trees where all observed sequences are placed as leafs, even though some of them are in fact ancestral. We therefore devised a method for post processing the inferred trees by collapsing short branches (thus relocating some leafs to internal nodes), and also present two new measures of tree similarity that takes into account the identity of both internal and leaf nodes. Based on this analysis we find that, among the investigated methods, CSI Phylogeny had the best performance, correctly identifying 73% of all branches in the

International Criticality Safety Benchmark Evaluation Project (ICSBEP) - ICSBEP 2015 Handbook

International Nuclear Information System (INIS)

Bess, John D.

2015-01-01

The Criticality Safety Benchmark Evaluation Project (CSBEP) was initiated in October of 1992 by the United States Department of Energy (DOE). The project quickly became an international effort as scientists from other interested countries became involved. The International Criticality Safety Benchmark Evaluation Project (ICSBEP) became an official activity of the Nuclear Energy Agency (NEA) in 1995. This handbook contains criticality safety benchmark specifications that have been derived from experiments performed at various critical facilities around the world. The benchmark specifications are intended for use by criticality safety engineers to validate calculation techniques used to establish minimum subcritical margins for operations with fissile material and to determine criticality alarm requirements and placement. Many of the specifications are also useful for nuclear data testing. Example calculations are presented; however, these calculations do not constitute a validation of the codes or cross-section data. The evaluated criticality safety benchmark data are given in nine volumes. These volumes span approximately 69000 pages and contain 567 evaluations with benchmark specifications for 4874 critical, near-critical or subcritical configurations, 31 criticality alarm placement/shielding configurations with multiple dose points for each, and 207 configurations that have been categorised as fundamental physics measurements that are relevant to criticality safety applications. New to the handbook are benchmark specifications for neutron activation foil and thermoluminescent dosimeter measurements performed at the SILENE critical assembly in Valduc, France as part of a joint venture in 2010 between the US DOE and the French Alternative Energies and Atomic Energy Commission (CEA). A photograph of this experiment is shown on the front cover. Experiments that are found unacceptable for use as criticality safety benchmark experiments are discussed in these

A Web Resource for Standardized Benchmark Datasets, Metrics, and Rosetta Protocols for Macromolecular Modeling and Design.

Directory of Open Access Journals (Sweden)

Shane Ó Conchúir

Full Text Available The development and validation of computational macromolecular modeling and design methods depend on suitable benchmark datasets and informative metrics for comparing protocols. In addition, if a method is intended to be adopted broadly in diverse biological applications, there needs to be information on appropriate parameters for each protocol, as well as metrics describing the expected accuracy compared to experimental data. In certain disciplines, there exist established benchmarks and public resources where experts in a particular methodology are encouraged to supply their most efficient implementation of each particular benchmark. We aim to provide such a resource for protocols in macromolecular modeling and design. We present a freely accessible web resource (https://kortemmelab.ucsf.edu/benchmarks to guide the development of protocols for protein modeling and design. The site provides benchmark datasets and metrics to compare the performance of a variety of modeling protocols using different computational sampling methods and energy functions, providing a "best practice" set of parameters for each method. Each benchmark has an associated downloadable benchmark capture archive containing the input files, analysis scripts, and tutorials for running the benchmark. The captures may be run with any suitable modeling method; we supply command lines for running the benchmarks using the Rosetta software suite. We have compiled initial benchmarks for the resource spanning three key areas: prediction of energetic effects of mutations, protein design, and protein structure prediction, each with associated state-of-the-art modeling protocols. With the help of the wider macromolecular modeling community, we hope to expand the variety of benchmarks included on the website and continue to evaluate new iterations of current methods as they become available.

Benchmarking in Mobarakeh Steel Company

OpenAIRE

Sasan Ghasemi; Mohammad Nazemi; Mehran Nejati

2008-01-01

Benchmarking is considered as one of the most effective ways of improving performance in companies. Although benchmarking in business organizations is a relatively new concept and practice, it has rapidly gained acceptance worldwide. This paper introduces the benchmarking project conducted in Esfahan's Mobarakeh Steel Company, as the first systematic benchmarking project conducted in Iran. It aims to share the process deployed for the benchmarking project in this company and illustrate how th...

How Activists Use Benchmarks

DEFF Research Database (Denmark)

Seabrooke, Leonard; Wigan, Duncan

2015-01-01

Non-governmental organisations use benchmarks as a form of symbolic violence to place political pressure on firms, states, and international organisations. The development of benchmarks requires three elements: (1) salience, that the community of concern is aware of the issue and views...... are put to the test. The first is a reformist benchmarking cycle where organisations defer to experts to create a benchmark that conforms with the broader system of politico-economic norms. The second is a revolutionary benchmarking cycle driven by expert-activists that seek to contest strong vested...... interests and challenge established politico-economic norms. Differentiating these cycles provides insights into how activists work through organisations and with expert networks, as well as how campaigns on complex economic issues can be mounted and sustained....

Method to stimulate dose gradient in liquid media

International Nuclear Information System (INIS)

Scarlat, F.

1993-01-01

The depth absorbed dose from electrons with energy higher than 10 MeV shows a distribution with a big-percentage absorbed dose at the entrance surface and a small dose gradient. This is due to the big distance between the virtual focus and irradiated liquid medium. In order to stimulate dose gradient and decrease the surface dose, this paper presents a method for obtaining the second focus by means of a magnetostatic planar wiggler. Preliminary calculations indicated that the absorbed dose rate increases two-three times at the reference plane in the irradiated liquid medium. (Author)

Benchmarking in Mobarakeh Steel Company

Directory of Open Access Journals (Sweden)

Sasan Ghasemi

2008-05-01

Full Text Available Benchmarking is considered as one of the most effective ways of improving performance incompanies. Although benchmarking in business organizations is a relatively new concept and practice, ithas rapidly gained acceptance worldwide. This paper introduces the benchmarking project conducted in Esfahan’s Mobarakeh Steel Company, as the first systematic benchmarking project conducted in Iran. It aimsto share the process deployed for the benchmarking project in this company and illustrate how the projectsystematic implementation led to succes.

Aquatic Life Benchmarks

Data.gov (United States)

U.S. Environmental Protection Agency — The Aquatic Life Benchmarks is an EPA-developed set of criteria for freshwater species. These benchmarks are based on toxicity values reviewed by EPA and used in the...

A matter of timing: identifying significant multi-dose radiotherapy improvements by numerical simulation and genetic algorithm search.

Directory of Open Access Journals (Sweden)

Simon D Angus

Full Text Available Multi-dose radiotherapy protocols (fraction dose and timing currently used in the clinic are the product of human selection based on habit, received wisdom, physician experience and intra-day patient timetabling. However, due to combinatorial considerations, the potential treatment protocol space for a given total dose or treatment length is enormous, even for relatively coarse search; well beyond the capacity of traditional in-vitro methods. In constrast, high fidelity numerical simulation of tumor development is well suited to the challenge. Building on our previous single-dose numerical simulation model of EMT6/Ro spheroids, a multi-dose irradiation response module is added and calibrated to the effective dose arising from 18 independent multi-dose treatment programs available in the experimental literature. With the developed model a constrained, non-linear, search for better performing cadidate protocols is conducted within the vicinity of two benchmarks by genetic algorithm (GA techniques. After evaluating less than 0.01% of the potential benchmark protocol space, candidate protocols were identified by the GA which conferred an average of 9.4% (max benefit 16.5% and 7.1% (13.3% improvement (reduction on tumour cell count compared to the two benchmarks, respectively. Noticing that a convergent phenomenon of the top performing protocols was their temporal synchronicity, a further series of numerical experiments was conducted with periodic time-gap protocols (10 h to 23 h, leading to the discovery that the performance of the GA search candidates could be replicated by 17-18 h periodic candidates. Further dynamic irradiation-response cell-phase analysis revealed that such periodicity cohered with latent EMT6/Ro cell-phase temporal patterning. Taken together, this study provides powerful evidence towards the hypothesis that even simple inter-fraction timing variations for a given fractional dose program may present a facile, and highly cost

A matter of timing: identifying significant multi-dose radiotherapy improvements by numerical simulation and genetic algorithm search.

Science.gov (United States)

Angus, Simon D; Piotrowska, Monika Joanna

2014-01-01

Multi-dose radiotherapy protocols (fraction dose and timing) currently used in the clinic are the product of human selection based on habit, received wisdom, physician experience and intra-day patient timetabling. However, due to combinatorial considerations, the potential treatment protocol space for a given total dose or treatment length is enormous, even for relatively coarse search; well beyond the capacity of traditional in-vitro methods. In constrast, high fidelity numerical simulation of tumor development is well suited to the challenge. Building on our previous single-dose numerical simulation model of EMT6/Ro spheroids, a multi-dose irradiation response module is added and calibrated to the effective dose arising from 18 independent multi-dose treatment programs available in the experimental literature. With the developed model a constrained, non-linear, search for better performing cadidate protocols is conducted within the vicinity of two benchmarks by genetic algorithm (GA) techniques. After evaluating less than 0.01% of the potential benchmark protocol space, candidate protocols were identified by the GA which conferred an average of 9.4% (max benefit 16.5%) and 7.1% (13.3%) improvement (reduction) on tumour cell count compared to the two benchmarks, respectively. Noticing that a convergent phenomenon of the top performing protocols was their temporal synchronicity, a further series of numerical experiments was conducted with periodic time-gap protocols (10 h to 23 h), leading to the discovery that the performance of the GA search candidates could be replicated by 17-18 h periodic candidates. Further dynamic irradiation-response cell-phase analysis revealed that such periodicity cohered with latent EMT6/Ro cell-phase temporal patterning. Taken together, this study provides powerful evidence towards the hypothesis that even simple inter-fraction timing variations for a given fractional dose program may present a facile, and highly cost-effecitive means

The institutionalization of benchmarking in the Danish construction industry

DEFF Research Database (Denmark)

Rasmussen, Grane Mikael Gregaard; Gottlieb, Stefan Christoffer

, the chapter accounts for the data collection methods used to conduct the empirical data collection and the appertaining choices that are made, based on the account for analyzing institutionalization processes. The analysis unfolds over seven chapters, starting with an exposition of the political foundation...... and disseminated to the construction industry. The fourth chapter demonstrates how benchmarking was concretized into a benchmarking system and articulated to address several political focus areas for the construction industry. BEC accordingly became a political arena where many local perspectives and strategic...... emerged as actors expressed diverse political interests in the institutionalization of benchmarking. The political struggles accounted for in chapter five constituted a powerful political pressure and called for transformations of the institutionalization in order for benchmarking to attain institutional...

75 FR 66057 - Waybill Data Released in Three-Benchmark Rail Rate Proceedings

Science.gov (United States)

2010-10-27

... (CSX Transp. II), 584 F.3d 1076 (DC Cir. 2009), the Board modified its simplified rail rate guidelines...- Benchmark approach for smaller rail rate disputes. The Three-Benchmark method compares a challenged rate of...: The RSAM and R/VC >180 benchmarks. See Rate Guidelines--Non-Coal Proceedings, (Rate Guidelines) 1 S.T...

Pool critical assembly pressure vessel facility benchmark

International Nuclear Information System (INIS)

Remec, I.; Kam, F.B.K.

1997-07-01

This pool critical assembly (PCA) pressure vessel wall facility benchmark (PCA benchmark) is described and analyzed in this report. Analysis of the PCA benchmark can be used for partial fulfillment of the requirements for the qualification of the methodology for pressure vessel neutron fluence calculations, as required by the US Nuclear Regulatory Commission regulatory guide DG-1053. Section 1 of this report describes the PCA benchmark and provides all data necessary for the benchmark analysis. The measured quantities, to be compared with the calculated values, are the equivalent fission fluxes. In Section 2 the analysis of the PCA benchmark is described. Calculations with the computer code DORT, based on the discrete-ordinates method, were performed for three ENDF/B-VI-based multigroup libraries: BUGLE-93, SAILOR-95, and BUGLE-96. An excellent agreement of the calculated (C) and measures (M) equivalent fission fluxes was obtained. The arithmetic average C/M for all the dosimeters (total of 31) was 0.93 ± 0.03 and 0.92 ± 0.03 for the SAILOR-95 and BUGLE-96 libraries, respectively. The average C/M ratio, obtained with the BUGLE-93 library, for the 28 measurements was 0.93 ± 0.03 (the neptunium measurements in the water and air regions were overpredicted and excluded from the average). No systematic decrease in the C/M ratios with increasing distance from the core was observed for any of the libraries used

Analytical Radiation Transport Benchmarks for The Next Century

International Nuclear Information System (INIS)

Ganapol, B.D.

2005-01-01

Verification of large-scale computational algorithms used in nuclear engineering and radiological applications is an essential element of reliable code performance. For this reason, the development of a suite of multidimensional semi-analytical benchmarks has been undertaken to provide independent verification of proper operation of codes dealing with the transport of neutral particles. The benchmarks considered cover several one-dimensional, multidimensional, monoenergetic and multigroup, fixed source and critical transport scenarios. The first approach, called the Green's Function. In slab geometry, the Green's function is incorporated into a set of integral equations for the boundary fluxes. Through a numerical Fourier transform inversion and subsequent matrix inversion for the boundary fluxes, a semi-analytical benchmark emerges. Multidimensional solutions in a variety of infinite media are also based on the slab Green's function. In a second approach, a new converged SN method is developed. In this method, the SN solution is ''minded'' to bring out hidden high quality solutions. For this case multigroup fixed source and criticality transport problems are considered. Remarkably accurate solutions can be obtained with this new method called the Multigroup Converged SN (MGCSN) method as will be demonstrated

Benchmarking and the laboratory

Science.gov (United States)

Galloway, M; Nadin, L

2001-01-01

This article describes how benchmarking can be used to assess laboratory performance. Two benchmarking schemes are reviewed, the Clinical Benchmarking Company's Pathology Report and the College of American Pathologists' Q-Probes scheme. The Clinical Benchmarking Company's Pathology Report is undertaken by staff based in the clinical management unit, Keele University with appropriate input from the professional organisations within pathology. Five annual reports have now been completed. Each report is a detailed analysis of 10 areas of laboratory performance. In this review, particular attention is focused on the areas of quality, productivity, variation in clinical practice, skill mix, and working hours. The Q-Probes scheme is part of the College of American Pathologists programme in studies of quality assurance. The Q-Probes scheme and its applicability to pathology in the UK is illustrated by reviewing two recent Q-Probe studies: routine outpatient test turnaround time and outpatient test order accuracy. The Q-Probes scheme is somewhat limited by the small number of UK laboratories that have participated. In conclusion, as a result of the government's policy in the UK, benchmarking is here to stay. Benchmarking schemes described in this article are one way in which pathologists can demonstrate that they are providing a cost effective and high quality service. Key Words: benchmarking • pathology PMID:11477112

Benchmarking for Higher Education.

Science.gov (United States)

Jackson, Norman, Ed.; Lund, Helen, Ed.

The chapters in this collection explore the concept of benchmarking as it is being used and developed in higher education (HE). Case studies and reviews show how universities in the United Kingdom are using benchmarking to aid in self-regulation and self-improvement. The chapters are: (1) "Introduction to Benchmarking" (Norman Jackson…

Benchmarking and Learning in Public Healthcare

DEFF Research Database (Denmark)

Buckmaster, Natalie; Mouritsen, Jan

2017-01-01

This research investigates the effects of learning-oriented benchmarking in public healthcare settings. Benchmarking is a widely adopted yet little explored accounting practice that is part of the paradigm of New Public Management. Extant studies are directed towards mandated coercive benchmarking...... applications. The present study analyses voluntary benchmarking in a public setting that is oriented towards learning. The study contributes by showing how benchmarking can be mobilised for learning and offers evidence of the effects of such benchmarking for performance outcomes. It concludes that benchmarking...... can enable learning in public settings but that this requires actors to invest in ensuring that benchmark data are directed towards improvement....

Benchmark job – Watch out!

CERN Multimedia

Staff Association

2017-01-01

On 12 December 2016, in Echo No. 259, we already discussed at length the MERIT and benchmark jobs. Still, we find that a couple of issues warrant further discussion. Benchmark job – administrative decision on 1 July 2017 On 12 January 2017, the HR Department informed all staff members of a change to the effective date of the administrative decision regarding benchmark jobs. The benchmark job title of each staff member will be confirmed on 1 July 2017, instead of 1 May 2017 as originally announced in HR’s letter on 18 August 2016. Postponing the administrative decision by two months will leave a little more time to address the issues related to incorrect placement in a benchmark job. Benchmark job – discuss with your supervisor, at the latest during the MERIT interview In order to rectify an incorrect placement in a benchmark job, it is essential that the supervisor and the supervisee go over the assigned benchmark job together. In most cases, this placement has been done autom...

DRAGON solutions to the 3D transport benchmark over a range in parameter space

International Nuclear Information System (INIS)

Martin, Nicolas; Hebert, Alain; Marleau, Guy

2010-01-01

DRAGON solutions to the 'NEA suite of benchmarks for 3D transport methods and codes over a range in parameter space' are discussed in this paper. A description of the benchmark is first provided, followed by a detailed review of the different computational models used in the lattice code DRAGON. Two numerical methods were selected for generating the required quantities for the 729 configurations of this benchmark. First, S N calculations were performed using fully symmetric angular quadratures and high-order diamond differencing for spatial discretization. To compare S N results with those of another deterministic method, the method of characteristics (MoC) was also considered for this benchmark. Comparisons between reference solutions, S N and MoC results illustrate the advantages and drawbacks of each methods for this 3-D transport problem.

A Benchmark and Simulator for UAV Tracking

KAUST Repository

Mueller, Matthias; Smith, Neil; Ghanem, Bernard

2016-01-01

In this paper, we propose a new aerial video dataset and benchmark for low altitude UAV target tracking, as well as, a photorealistic UAV simulator that can be coupled with tracking methods. Our benchmark provides the first evaluation of many state-of-the-art and popular trackers on 123 new and fully annotated HD video sequences captured from a low-altitude aerial perspective. Among the compared trackers, we determine which ones are the most suitable for UAV tracking both in terms of tracking accuracy and run-time. The simulator can be used to evaluate tracking algorithms in real-time scenarios before they are deployed on a UAV “in the field”, as well as, generate synthetic but photo-realistic tracking datasets with automatic ground truth annotations to easily extend existing real-world datasets. Both the benchmark and simulator are made publicly available to the vision community on our website to further research in the area of object tracking from UAVs. (https://ivul.kaust.edu.sa/Pages/pub-benchmark-simulator-uav.aspx.). © Springer International Publishing AG 2016.

A Benchmark and Simulator for UAV Tracking

KAUST Repository

Mueller, Matthias

2016-09-16

In this paper, we propose a new aerial video dataset and benchmark for low altitude UAV target tracking, as well as, a photorealistic UAV simulator that can be coupled with tracking methods. Our benchmark provides the first evaluation of many state-of-the-art and popular trackers on 123 new and fully annotated HD video sequences captured from a low-altitude aerial perspective. Among the compared trackers, we determine which ones are the most suitable for UAV tracking both in terms of tracking accuracy and run-time. The simulator can be used to evaluate tracking algorithms in real-time scenarios before they are deployed on a UAV “in the field”, as well as, generate synthetic but photo-realistic tracking datasets with automatic ground truth annotations to easily extend existing real-world datasets. Both the benchmark and simulator are made publicly available to the vision community on our website to further research in the area of object tracking from UAVs. (https://ivul.kaust.edu.sa/Pages/pub-benchmark-simulator-uav.aspx.). © Springer International Publishing AG 2016.

Benchmarking reference services: an introduction.

Science.gov (United States)

Marshall, J G; Buchanan, H S

1995-01-01

Benchmarking is based on the common sense idea that someone else, either inside or outside of libraries, has found a better way of doing certain things and that your own library's performance can be improved by finding out how others do things and adopting the best practices you find. Benchmarking is one of the tools used for achieving continuous improvement in Total Quality Management (TQM) programs. Although benchmarking can be done on an informal basis, TQM puts considerable emphasis on formal data collection and performance measurement. Used to its full potential, benchmarking can provide a common measuring stick to evaluate process performance. This article introduces the general concept of benchmarking, linking it whenever possible to reference services in health sciences libraries. Data collection instruments that have potential application in benchmarking studies are discussed and the need to develop common measurement tools to facilitate benchmarking is emphasized.

Benchmarking criticality safety calculations with subcritical experiments

International Nuclear Information System (INIS)

Mihalczo, J.T.

1984-06-01

Calculation of the neutron multiplication factor at delayed criticality may be necessary for benchmarking calculations but it may not be sufficient. The use of subcritical experiments to benchmark criticality safety calculations could result in substantial savings in fuel material costs for experiments. In some cases subcritical configurations could be used to benchmark calculations where sufficient fuel to achieve delayed criticality is not available. By performing a variety of measurements with subcritical configurations, much detailed information can be obtained which can be compared directly with calculations. This paper discusses several measurements that can be performed with subcritical assemblies and presents examples that include comparisons between calculation and experiment where possible. Where not, examples from critical experiments have been used but the measurement methods could also be used for subcritical experiments

Internet based benchmarking

DEFF Research Database (Denmark)

Bogetoft, Peter; Nielsen, Kurt

2005-01-01

We discuss the design of interactive, internet based benchmarking using parametric (statistical) as well as nonparametric (DEA) models. The user receives benchmarks and improvement potentials. The user is also given the possibility to search different efficiency frontiers and hereby to explore...

Optimizing CT radiation dose based on patient size and image quality: the size-specific dose estimate method

Energy Technology Data Exchange (ETDEWEB)

Larson, David B. [Stanford University School of Medicine, Department of Radiology, Stanford, CA (United States)

2014-10-15

The principle of ALARA (dose as low as reasonably achievable) calls for dose optimization rather than dose reduction, per se. Optimization of CT radiation dose is accomplished by producing images of acceptable diagnostic image quality using the lowest dose method available. Because it is image quality that constrains the dose, CT dose optimization is primarily a problem of image quality rather than radiation dose. Therefore, the primary focus in CT radiation dose optimization should be on image quality. However, no reliable direct measure of image quality has been developed for routine clinical practice. Until such measures become available, size-specific dose estimates (SSDE) can be used as a reasonable image-quality estimate. The SSDE method of radiation dose optimization for CT abdomen and pelvis consists of plotting SSDE for a sample of examinations as a function of patient size, establishing an SSDE threshold curve based on radiologists' assessment of image quality, and modifying protocols to consistently produce doses that are slightly above the threshold SSDE curve. Challenges in operationalizing CT radiation dose optimization include data gathering and monitoring, managing the complexities of the numerous protocols, scanners and operators, and understanding the relationship of the automated tube current modulation (ATCM) parameters to image quality. Because CT manufacturers currently maintain their ATCM algorithms as secret for proprietary reasons, prospective modeling of SSDE for patient populations is not possible without reverse engineering the ATCM algorithm and, hence, optimization by this method requires a trial-and-error approach. (orig.)

Benchmarking in academic pharmacy departments.

Science.gov (United States)

Bosso, John A; Chisholm-Burns, Marie; Nappi, Jean; Gubbins, Paul O; Ross, Leigh Ann

2010-10-11

Benchmarking in academic pharmacy, and recommendations for the potential uses of benchmarking in academic pharmacy departments are discussed in this paper. Benchmarking is the process by which practices, procedures, and performance metrics are compared to an established standard or best practice. Many businesses and industries use benchmarking to compare processes and outcomes, and ultimately plan for improvement. Institutions of higher learning have embraced benchmarking practices to facilitate measuring the quality of their educational and research programs. Benchmarking is used internally as well to justify the allocation of institutional resources or to mediate among competing demands for additional program staff or space. Surveying all chairs of academic pharmacy departments to explore benchmarking issues such as department size and composition, as well as faculty teaching, scholarly, and service productivity, could provide valuable information. To date, attempts to gather this data have had limited success. We believe this information is potentially important, urge that efforts to gather it should be continued, and offer suggestions to achieve full participation.

Towards benchmarking an in-stream water quality model

Directory of Open Access Journals (Sweden)

2007-01-01

Full Text Available A method of model evaluation is presented which utilises a comparison with a benchmark model. The proposed benchmarking concept is one that can be applied to many hydrological models but, in this instance, is implemented in the context of an in-stream water quality model. The benchmark model is defined in such a way that it is easily implemented within the framework of the test model, i.e. the approach relies on two applications of the same model code rather than the application of two separate model codes. This is illustrated using two case studies from the UK, the Rivers Aire and Ouse, with the objective of simulating a water quality classification, general quality assessment (GQA, which is based on dissolved oxygen, biochemical oxygen demand and ammonium. Comparisons between the benchmark and test models are made based on GQA, as well as a step-wise assessment against the components required in its derivation. The benchmarking process yields a great deal of important information about the performance of the test model and raises issues about a priori definition of the assessment criteria.

Lessons Learned on Benchmarking from the International Human Reliability Analysis Empirical Study

International Nuclear Information System (INIS)

Boring, Ronald L.; Forester, John A.; Bye, Andreas; Dang, Vinh N.; Lois, Erasmia

2010-01-01

The International Human Reliability Analysis (HRA) Empirical Study is a comparative benchmark of the prediction of HRA methods to the performance of nuclear power plant crews in a control room simulator. There are a number of unique aspects to the present study that distinguish it from previous HRA benchmarks, most notably the emphasis on a method-to-data comparison instead of a method-to-method comparison. This paper reviews seven lessons learned about HRA benchmarking from conducting the study: (1) the dual purposes of the study afforded by joining another HRA study; (2) the importance of comparing not only quantitative but also qualitative aspects of HRA; (3) consideration of both negative and positive drivers on crew performance; (4) a relatively large sample size of crews; (5) the use of multiple methods and scenarios to provide a well-rounded view of HRA performance; (6) the importance of clearly defined human failure events; and (7) the use of a common comparison language to 'translate' the results of different HRA methods. These seven lessons learned highlight how the present study can serve as a useful template for future benchmarking studies.

Lessons Learned on Benchmarking from the International Human Reliability Analysis Empirical Study

Energy Technology Data Exchange (ETDEWEB)

Ronald L. Boring; John A. Forester; Andreas Bye; Vinh N. Dang; Erasmia Lois

2010-06-01

The International Human Reliability Analysis (HRA) Empirical Study is a comparative benchmark of the prediction of HRA methods to the performance of nuclear power plant crews in a control room simulator. There are a number of unique aspects to the present study that distinguish it from previous HRA benchmarks, most notably the emphasis on a method-to-data comparison instead of a method-to-method comparison. This paper reviews seven lessons learned about HRA benchmarking from conducting the study: (1) the dual purposes of the study afforded by joining another HRA study; (2) the importance of comparing not only quantitative but also qualitative aspects of HRA; (3) consideration of both negative and positive drivers on crew performance; (4) a relatively large sample size of crews; (5) the use of multiple methods and scenarios to provide a well-rounded view of HRA performance; (6) the importance of clearly defined human failure events; and (7) the use of a common comparison language to “translate” the results of different HRA methods. These seven lessons learned highlight how the present study can serve as a useful template for future benchmarking studies.

The D1 method: career dose estimation from a combination of historical monitoring data and a single year's dose data

International Nuclear Information System (INIS)

Sont, W.N.

1995-01-01

A method is introduced to estimate career doses from a combination of historical monitoring data and a single year's dose data. This method, called D1 eliminates the bias arising from incorporating historical dose data from times when occupational doses were generally much higher than they are today. Doses calculated by this method are still conditional on the preservation of the status quo in the effectiveness of radiation protection. The method takes into account the variation of the annual dose, and of the probability of being monitored, with the time elapsed since the start of a career. It also allows for the calculation of a standard error of the projected career dose. Results from recent Canadian dose data are presented. (author)

Benchmark studies of induced radioactivity and remanent dose rates produced in LHC materials

International Nuclear Information System (INIS)

Brugger, M.; Mayer, S.; Roesler, S.; Ulrici, L.; Khater, H.; Prinz, A.; Vincke, H.

2005-01-01

Samples of materials that will be used for elements of the LHC machine as well as for shielding and construction components were irradiated in the stray radiation field of the CERN-EU high-energy Reference Field facility. The materials included various types of steel, copper, titanium, concrete and marble as well as light materials such as carbon composites and boron nitride. Emphasis was put on an accurate recording of the irradiation conditions, such as irradiation profile and intensity, and on a detailed determination of the elemental composition of the samples. After the irradiation, the specific activity induced in the samples as well as the remanent dose rate were measured at different cooling times ranging from about 20 minutes to two months. Furthermore, the irradiation experiment was simulated using the FLUKA Monte Carlo code and specific activities. In addition, dose rates were calculated. The latter was based on a new method simulating the production of various isotopes and the electromagnetic cascade induced by radioactive decay at a certain cooling time. In general, solid agreement was found, which engenders confidence in the predictive power of the applied codes and tools for the estimation of the radioactive nuclide inventory of the LHC machine as well as the calculation of remanent doses to personnel during interventions. (authors)

Benchmarking optimization solvers for structural topology optimization

DEFF Research Database (Denmark)

Rojas Labanda, Susana; Stolpe, Mathias

2015-01-01

solvers in IPOPT and FMINCON, and the sequential quadratic programming method in SNOPT, are benchmarked on the library using performance profiles. Whenever possible the methods are applied to both the nested and the Simultaneous Analysis and Design (SAND) formulations of the problem. The performance...

Study on the shipboard radar reconnaissance equipment azimuth benchmark method

Science.gov (United States)

Liu, Zhenxing; Jiang, Ning; Ma, Qian; Liu, Songtao; Wang, Longtao

2015-10-01

The future naval battle will take place in a complex electromagnetic environment. Therefore, seizing the electromagnetic superiority has become the major actions of the navy. Radar reconnaissance equipment is an important part of the system to obtain and master battlefield electromagnetic radiation source information. Azimuth measurement function is one of the main function radar reconnaissance equipments. Whether the accuracy of direction finding meets the requirements, determines the vessels successful or not active jamming, passive jamming, guided missile attack and other combat missions, having a direct bearing on the vessels combat capabilities . How to test the performance of radar reconnaissance equipment, while affecting the task as little as possible is a problem. This paper, based on radar signal simulator and GPS positioning equipment, researches and experiments on one new method, which povides the azimuth benchmark required by the direction-finding precision test anytime anywhere, for the ships at jetty to test radar reconnaissance equipment performance in direction-finding. It provides a powerful means for the naval radar reconnaissance equipments daily maintenance and repair work[1].

Benchmarking of venous thromboembolism prophylaxis practice with ENT.UK guidelines.

Science.gov (United States)

Al-Qahtani, Ali S

2017-05-01

The aim of this study was to benchmark our guidelines of prevention of venous thromboembolism (VTE) in ENT surgical population against ENT.UK guidelines, and also to encourage healthcare providers to utilize benchmarking as an effective method of improving performance. The study design is prospective descriptive analysis. The setting of this study is tertiary referral centre (Assir Central Hospital, Abha, Saudi Arabia). In this study, we are benchmarking our practice guidelines of the prevention of VTE in the ENT surgical population against that of ENT.UK guidelines to mitigate any gaps. ENT guidelines 2010 were downloaded from the ENT.UK Website. Our guidelines were compared with the possibilities that either our performance meets or fall short of ENT.UK guidelines. Immediate corrective actions will take place if there is quality chasm between the two guidelines. ENT.UK guidelines are evidence-based and updated which may serve as role-model for adoption and benchmarking. Our guidelines were accordingly amended to contain all factors required in providing a quality service to ENT surgical patients. While not given appropriate attention, benchmarking is a useful tool in improving quality of health care. It allows learning from others' practices and experiences, and works towards closing any quality gaps. In addition, benchmarking clinical outcomes is critical for quality improvement and informing decisions concerning service provision. It is recommended to be included on the list of quality improvement methods of healthcare services.

Estimation of benchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, β 2-microglobulin, and N-acetyl-β-D-glucosaminidase in cadmium nonpolluted regions in Japan

International Nuclear Information System (INIS)

Kobayashi, Etsuko; Suwazono, Yasushi; Uetani, Mirei; Inaba, Takeya; Oishi, Mitsuhiro; Kido, Teruhiko; Nishijo, Muneko; Nakagawa, Hideaki; Nogawa, Koji

2006-01-01

Previously, we investigated the association between urinary cadmium (Cd) concentration and indicators of renal dysfunction, including total protein, β 2 -microglobulin (β 2 -MG), and N-acetyl-β-D-glucosaminidase (NAG). In 2778 inhabitants ≥50 years of age (1114 men, 1664 women) in three different Cd nonpolluted areas in Japan, we showed that a dose-response relationship existed between renal effects and Cd exposure in the general environment without any known Cd pollution. However, we could not estimate the threshold levels of urinary Cd at that time. In the present study, we estimated the threshold levels of urinary Cd as the benchmark dose low (BMDL) using the benchmark dose (BMD) approach. Urinary Cd excretion was divided into 10 categories, and an abnormality rate was calculated for each. Cut-off values for urinary substances were defined as corresponding to the 84% and 95% upper limit values of the target population who have not smoked. Then we calculated the BMD and BMDL using a log-logistic model. The values of BMD and BMDL for all urinary substances could be calculated. The BMDL for the 84% cut-off value of β 2 -MG, setting an abnormal value at 5%, was 2.4 μg/g creatinine (cr) in men and 3.3 μg/g cr in women. In conclusion, the present study demonstrated that the threshold level of urinary Cd could be estimated in people living in the general environment without any known Cd-pollution in Japan, and the value was inferred to be almost the same as that in Belgium, Sweden, and China

Standard Guide for Benchmark Testing of Light Water Reactor Calculations

CERN Document Server

American Society for Testing and Materials. Philadelphia

2010-01-01

1.1 This guide covers general approaches for benchmarking neutron transport calculations in light water reactor systems. A companion guide (Guide E2005) covers use of benchmark fields for testing neutron transport calculations and cross sections in well controlled environments. This guide covers experimental benchmarking of neutron fluence calculations (or calculations of other exposure parameters such as dpa) in more complex geometries relevant to reactor surveillance. Particular sections of the guide discuss: the use of well-characterized benchmark neutron fields to provide an indication of the accuracy of the calculational methods and nuclear data when applied to typical cases; and the use of plant specific measurements to indicate bias in individual plant calculations. Use of these two benchmark techniques will serve to limit plant-specific calculational uncertainty, and, when combined with analytical uncertainty estimates for the calculations, will provide uncertainty estimates for reactor fluences with ...

Using Benchmarking To Strengthen the Assessment of Persistence.

Science.gov (United States)

McLachlan, Michael S; Zou, Hongyan; Gouin, Todd

2017-01-03

Chemical persistence is a key property for assessing chemical risk and chemical hazard. Current methods for evaluating persistence are based on laboratory tests. The relationship between the laboratory based estimates and persistence in the environment is often unclear, in which case the current methods for evaluating persistence can be questioned. Chemical benchmarking opens new possibilities to measure persistence in the field. In this paper we explore how the benchmarking approach can be applied in both the laboratory and the field to deepen our understanding of chemical persistence in the environment and create a firmer scientific basis for laboratory to field extrapolation of persistence test results.

Benchmark calculations for VENUS-2 MOX -fueled reactor dosimetry

International Nuclear Information System (INIS)

Kim, Jong Kung; Kim, Hong Chul; Shin, Chang Ho; Han, Chi Young; Na, Byung Chan

2004-01-01

As a part of a Nuclear Energy Agency (NEA) Project, it was pursued the benchmark for dosimetry calculation of the VENUS-2 MOX-fueled reactor. In this benchmark, the goal is to test the current state-of-the-art computational methods of calculating neutron flux to reactor components against the measured data of the VENUS-2 MOX-fuelled critical experiments. The measured data to be used for this benchmark are the equivalent fission fluxes which are the reaction rates divided by the U 235 fission spectrum averaged cross-section of the corresponding dosimeter. The present benchmark is, therefore, defined to calculate reaction rates and corresponding equivalent fission fluxes measured on the core-mid plane at specific positions outside the core of the VENUS-2 MOX-fuelled reactor. This is a follow-up exercise to the previously completed UO 2 -fuelled VENUS-1 two-dimensional and VENUS-3 three-dimensional exercises. The use of MOX fuel in LWRs presents different neutron characteristics and this is the main interest of the current benchmark compared to the previous ones

Benchmarking ENDF/B-VII.0

International Nuclear Information System (INIS)

Marck, Steven C. van der

2006-01-01

The new major release VII.0 of the ENDF/B nuclear data library has been tested extensively using benchmark calculations. These were based upon MCNP-4C3 continuous-energy Monte Carlo neutronics simulations, together with nuclear data processed using the code NJOY. Three types of benchmarks were used, viz., criticality safety benchmarks (fusion) shielding benchmarks, and reference systems for which the effective delayed neutron fraction is reported. For criticality safety, more than 700 benchmarks from the International Handbook of Criticality Safety Benchmark Experiments were used. Benchmarks from all categories were used, ranging from low-enriched uranium, compound fuel, thermal spectrum ones (LEU-COMP-THERM), to mixed uranium-plutonium, metallic fuel, fast spectrum ones (MIX-MET-FAST). For fusion shielding many benchmarks were based on IAEA specifications for the Oktavian experiments (for Al, Co, Cr, Cu, LiF, Mn, Mo, Si, Ti, W, Zr), Fusion Neutronics Source in Japan (for Be, C, N, O, Fe, Pb), and Pulsed Sphere experiments at Lawrence Livermore National Laboratory (for 6 Li, 7 Li, Be, C, N, O, Mg, Al, Ti, Fe, Pb, D 2 O, H 2 O, concrete, polyethylene and teflon). For testing delayed neutron data more than thirty measurements in widely varying systems were used. Among these were measurements in the Tank Critical Assembly (TCA in Japan) and IPEN/MB-01 (Brazil), both with a thermal spectrum, and two cores in Masurca (France) and three cores in the Fast Critical Assembly (FCA, Japan), all with fast spectra. In criticality safety, many benchmarks were chosen from the category with a thermal spectrum, low-enriched uranium, compound fuel (LEU-COMP-THERM), because this is typical of most current-day reactors, and because these benchmarks were previously underpredicted by as much as 0.5% by most nuclear data libraries (such as ENDF/B-VI.8, JEFF-3.0). The calculated results presented here show that this underprediction is no longer there for ENDF/B-VII.0. The average over 257

Defining a methodology for benchmarking spectrum unfolding codes

International Nuclear Information System (INIS)

Meyer, W.; Kirmser, P.G.; Miller, W.H.; Hu, K.K.

1976-01-01

It has long been recognized that different neutron spectrum unfolding codes will produce significantly different results when unfolding the same measured data. In reviewing the results of such analyses it has been difficult to determine which result if any is the best representation of what was measured by the spectrometer detector. A proposal to develop a benchmarking procedure for spectrum unfolding codes is presented. The objective of the procedure will be to begin to develop a methodology and a set of data with a well established and documented result that could be used to benchmark and standardize the various unfolding methods and codes. It is further recognized that development of such a benchmark must involve a consensus of the technical community interested in neutron spectrum unfolding

Application of the dose rate spectroscopy to the dose-to-curie conversion method using a NaI(Tl) detector

International Nuclear Information System (INIS)

JI, Young-Yong; Chung, Kun Ho; Kim, Chang-Jong; Kang, Mun Ja; Park, Sang Tae

2015-01-01

Dose rate spectroscopy is a very useful method to directly calculate the individual dose rate from the converted energy spectrum for the dose rate using the G-factor which is related to the used detector response function. A DTC conversion method for the estimation of the radioactivity based on the measured dose rate from the radioactive materials can then be modified into a simple equation using the dose rate spectroscopy. In order to make the method validation of the modified DTC conversion method, experimental verifications using a 3″φx3″ NaI(Tl) detector were conducted at the simple geometry of the point source located onto a detector and more complex geometries which mean the assay of the simulated radioactive material. In addition, the linearity about the results from the modified DTC conversion method was also estimated by increasing the distance between source positions and a detector to confirm the method validation in the energy, dose rate, and distance range of the gamma nuclides. - Highlights: • A modified DTC conversion method using the dose rate spectroscopy was established. • In-situ calibration factors were calculated from the MCNP simulation. • Radioactivities of the disk sources were accurately calculated using a modified DTC conversion method. • A modified DTC conversion method was applied to the assay of the radioactive material

Benchmarking in Foodservice Operations

National Research Council Canada - National Science Library

Johnson, Bonnie

1998-01-01

The objective of this study was to identify usage of foodservice performance measures, important activities in foodservice benchmarking, and benchmarking attitudes, beliefs, and practices by foodservice directors...

Benchmarking, benchmarks, or best practices? Applying quality improvement principles to decrease surgical turnaround time.

Science.gov (United States)

Mitchell, L

1996-01-01

The processes of benchmarking, benchmark data comparative analysis, and study of best practices are distinctly different. The study of best practices is explained with an example based on the Arthur Andersen & Co. 1992 "Study of Best Practices in Ambulatory Surgery". The results of a national best practices study in ambulatory surgery were used to provide our quality improvement team with the goal of improving the turnaround time between surgical cases. The team used a seven-step quality improvement problem-solving process to improve the surgical turnaround time. The national benchmark for turnaround times between surgical cases in 1992 was 13.5 minutes. The initial turnaround time at St. Joseph's Medical Center was 19.9 minutes. After the team implemented solutions, the time was reduced to an average of 16.3 minutes, an 18% improvement. Cost-benefit analysis showed a potential enhanced revenue of approximately $300,000, or a potential savings of $10,119. Applying quality improvement principles to benchmarking, benchmarks, or best practices can improve process performance. Understanding which form of benchmarking the institution wishes to embark on will help focus a team and use appropriate resources. Communicating with professional organizations that have experience in benchmarking will save time and money and help achieve the desired results.

Benchmarking i den offentlige sektor

DEFF Research Database (Denmark)

Bukh, Per Nikolaj; Dietrichson, Lars; Sandalgaard, Niels

2008-01-01

I artiklen vil vi kort diskutere behovet for benchmarking i fraværet af traditionelle markedsmekanismer. Herefter vil vi nærmere redegøre for, hvad benchmarking er med udgangspunkt i fire forskellige anvendelser af benchmarking. Regulering af forsyningsvirksomheder vil blive behandlet, hvorefter...

Comparison of the dose evaluation methods for criticality accident

International Nuclear Information System (INIS)

Shimizu, Yoshio; Oka, Tsutomu

2004-01-01

The improvement of the dose evaluation method for criticality accidents is important to rationalize design of the nuclear fuel cycle facilities. The source spectrums of neutron and gamma ray of a criticality accident depend on the condition of the source, its materials, moderation, density and so on. The comparison of the dose evaluation methods for a criticality accident is made. Some methods, which are combination of criticality calculation and shielding calculation, are proposed. Prompt neutron and gamma ray doses from nuclear criticality of some uranium systems have been evaluated as the Nuclear Criticality Slide Rule. The uranium metal source (unmoderated system) and the uranyl nitrate solution source (moderated system) in the rule are evaluated by some calculation methods, which are combinations of code and cross section library, as follows: (a) SAS1X (ENDF/B-IV), (b) MCNP4C (ENDF/B-VI)-ANISN (DLC23E or JSD120), (c) MCNP4C-MCNP4C (ENDF/B-VI). They have consisted of criticality calculation and shielding calculation. These calculation methods are compared about the tissue absorbed dose and the spectrums at 2 m from the source. (author)

Regional Competitive Intelligence: Benchmarking and Policymaking

OpenAIRE

Huggins , Robert

2010-01-01

Benchmarking exercises have become increasingly popular within the sphere of regional policymaking in recent years. The aim of this paper is to analyse the concept of regional benchmarking and its links with regional policymaking processes. It develops a typology of regional benchmarking exercises and regional benchmarkers, and critically reviews the literature, both academic and policy oriented. It is argued that critics who suggest regional benchmarking is a flawed concept and technique fai...

Generalization of Asaoka method to linearly anisotropic scattering: benchmark data in cylindrical geometry

International Nuclear Information System (INIS)

Sanchez, Richard.

1975-11-01

The Integral Transform Method for the neutron transport equation has been developed in last years by Asaoka and others. The method uses Fourier transform techniques in solving isotropic one-dimensional transport problems in homogeneous media. The method has been extended to linearly anisotropic transport in one-dimensional homogeneous media. Series expansions were also obtained using Hembd techniques for the new anisotropic matrix elements in cylindrical geometry. Carlvik spatial-spherical harmonics method was generalized to solve the same problem. By applying a relation between the isotropic and anisotropic one-dimensional kernels, it was demonstrated that anisotropic matrix elements can be calculated by a linear combination of a few isotropic matrix elements. This means in practice that the anisotropic problem of order N with the N+2 isotropic matrix for the plane and spherical geometries, and N+1 isotropic matrix for cylindrical geometries can be solved. A method of solving linearly anisotropic one-dimensional transport problems in homogeneous media was defined by applying Mika and Stankiewicz observations: isotropic matrix elements were computed by Hembd series and anisotropic matrix elements then calculated from recursive relations. The method has been applied to albedo and critical problems in cylindrical geometries. Finally, a number of results were computed with 12-digit accuracy for use as benchmarks [fr

2010 Criticality Accident Alarm System Benchmark Experiments At The CEA Valduc SILENE Facility

International Nuclear Information System (INIS)

Miller, Thomas Martin; Dunn, Michael E.; Wagner, John C.; McMahan, Kimberly L.; Authier, Nicolas; Jacquet, Xavier; Rousseau, Guillaume; Wolff, Herve; Piot, Jerome; Savanier, Laurence; Baclet, Nathalie; Lee, Yi-kang; Masse, Veronique; Trama, Jean-Christophe; Gagnier, Emmanuel; Naury, Sylvie; Lenain, Richard; Hunter, Richard; Kim, Soon; Dulik, George Michael; Reynolds, Kevin H.

2011-01-01

Several experiments were performed at the CEA Valduc SILENE reactor facility, which are intended to be published as evaluated benchmark experiments in the ICSBEP Handbook. These evaluated benchmarks will be useful for the verification and validation of radiation transport codes and evaluated nuclear data, particularly those that are used in the analysis of CAASs. During these experiments SILENE was operated in pulsed mode in order to be representative of a criticality accident, which is rare among shielding benchmarks. Measurements of the neutron flux were made with neutron activation foils and measurements of photon doses were made with TLDs. Also unique to these experiments was the presence of several detectors used in actual CAASs, which allowed for the observation of their behavior during an actual critical pulse. This paper presents the preliminary measurement data currently available from these experiments. Also presented are comparisons of preliminary computational results with Scale and TRIPOLI-4 to the preliminary measurement data.

Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs.

Science.gov (United States)

Andreasen, Nancy C; Pressler, Marcus; Nopoulos, Peg; Miller, Del; Ho, Beng-Choon

2010-02-01

A standardized quantitative method for comparing dosages of different drugs is a useful tool for designing clinical trials and for examining the effects of long-term medication side effects such as tardive dyskinesia. Such a method requires establishing dose equivalents. An expert consensus group has published charts of equivalent doses for various antipsychotic medications for first- and second-generation medications. These charts were used in this study. Regression was used to compare each drug in the experts' charts to chlorpromazine and haloperidol and to create formulas for each relationship. The formulas were solved for chlorpromazine 100 mg and haloperidol 2 mg to derive new chlorpromazine and haloperidol equivalents. The formulas were incorporated into our definition of dose-years such that 100 mg/day of chlorpromazine equivalent or 2 mg/day of haloperidol equivalent taken for 1 year is equal to one dose-year. All comparisons to chlorpromazine and haloperidol were highly linear with R(2) values greater than .9. A power transformation further improved linearity. By deriving a unique formula that converts doses to chlorpromazine or haloperidol equivalents, we can compare otherwise dissimilar drugs. These equivalents can be multiplied by the time an individual has been on a given dose to derive a cumulative value measured in dose-years in the form of (chlorpromazine equivalent in mg) x (time on dose measured in years). After each dose has been converted to dose-years, the results can be summed to provide a cumulative quantitative measure of lifetime exposure. Copyright 2010 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Two gamma dose evaluation methods for silicon semiconductor detector

International Nuclear Information System (INIS)

Chen Faguo; Jin Gen; Yang Yapeng; Xu Yuan

2011-01-01

Silicon PIN diodes have been widely used as personal and areal dosimeters because of their small volume, simplicity and real-time operation. However, because silicon is neither a tissue-equivalent nor an air-equivalent material, an intrinsic disadvantage for silicon dosimeters is that a significant over-response occurs at low-energy region, especially below 200 keV. Using a energy compensation filter to flatten the energy response is one method overcoming this disadvantage. But for dose compensation method, the estimated dose depends only on the number of the detector pulses. So a weight function method was introduced to evaluate gamma dose, which depends on pulse number as well as its amplitude. (authors)

Simplified two and three dimensional HTTR benchmark problems

International Nuclear Information System (INIS)

Zhang Zhan; Rahnema, Farzad; Zhang Dingkang; Pounders, Justin M.; Ougouag, Abderrafi M.

2011-01-01

To assess the accuracy of diffusion or transport methods for reactor calculations, it is desirable to create heterogeneous benchmark problems that are typical of whole core configurations. In this paper we have created two and three dimensional numerical benchmark problems typical of high temperature gas cooled prismatic cores. Additionally, a single cell and single block benchmark problems are also included. These problems were derived from the HTTR start-up experiment. Since the primary utility of the benchmark problems is in code-to-code verification, minor details regarding geometry and material specification of the original experiment have been simplified while retaining the heterogeneity and the major physics properties of the core from a neutronics viewpoint. A six-group material (macroscopic) cross section library has been generated for the benchmark problems using the lattice depletion code HELIOS. Using this library, Monte Carlo solutions are presented for three configurations (all-rods-in, partially-controlled and all-rods-out) for both the 2D and 3D problems. These solutions include the core eigenvalues, the block (assembly) averaged fission densities, local peaking factors, the absorption densities in the burnable poison and control rods, and pin fission density distribution for selected blocks. Also included are the solutions for the single cell and single block problems.

Two new computational methods for universal DNA barcoding: a benchmark using barcode sequences of bacteria, archaea, animals, fungi, and land plants.

Science.gov (United States)

Tanabe, Akifumi S; Toju, Hirokazu

2013-01-01

Taxonomic identification of biological specimens based on DNA sequence information (a.k.a. DNA barcoding) is becoming increasingly common in biodiversity science. Although several methods have been proposed, many of them are not universally applicable due to the need for prerequisite phylogenetic/machine-learning analyses, the need for huge computational resources, or the lack of a firm theoretical background. Here, we propose two new computational methods of DNA barcoding and show a benchmark for bacterial/archeal 16S, animal COX1, fungal internal transcribed spacer, and three plant chloroplast (rbcL, matK, and trnH-psbA) barcode loci that can be used to compare the performance of existing and new methods. The benchmark was performed under two alternative situations: query sequences were available in the corresponding reference sequence databases in one, but were not available in the other. In the former situation, the commonly used "1-nearest-neighbor" (1-NN) method, which assigns the taxonomic information of the most similar sequences in a reference database (i.e., BLAST-top-hit reference sequence) to a query, displays the highest rate and highest precision of successful taxonomic identification. However, in the latter situation, the 1-NN method produced extremely high rates of misidentification for all the barcode loci examined. In contrast, one of our new methods, the query-centric auto-k-nearest-neighbor (QCauto) method, consistently produced low rates of misidentification for all the loci examined in both situations. These results indicate that the 1-NN method is most suitable if the reference sequences of all potentially observable species are available in databases; otherwise, the QCauto method returns the most reliable identification results. The benchmark results also indicated that the taxon coverage of reference sequences is far from complete for genus or species level identification in all the barcode loci examined. Therefore, we need to accelerate

Benchmarking Using Basic DBMS Operations

Science.gov (United States)

Crolotte, Alain; Ghazal, Ahmad

The TPC-H benchmark proved to be successful in the decision support area. Many commercial database vendors and their related hardware vendors used these benchmarks to show the superiority and competitive edge of their products. However, over time, the TPC-H became less representative of industry trends as vendors keep tuning their database to this benchmark-specific workload. In this paper, we present XMarq, a simple benchmark framework that can be used to compare various software/hardware combinations. Our benchmark model is currently composed of 25 queries that measure the performance of basic operations such as scans, aggregations, joins and index access. This benchmark model is based on the TPC-H data model due to its maturity and well-understood data generation capability. We also propose metrics to evaluate single-system performance and compare two systems. Finally we illustrate the effectiveness of this model by showing experimental results comparing two systems under different conditions.

High Energy Physics (HEP) benchmark program

International Nuclear Information System (INIS)

Yasu, Yoshiji; Ichii, Shingo; Yashiro, Shigeo; Hirayama, Hideo; Kokufuda, Akihiro; Suzuki, Eishin.

1993-01-01

High Energy Physics (HEP) benchmark programs are indispensable tools to select suitable computer for HEP application system. Industry standard benchmark programs can not be used for this kind of particular selection. The CERN and the SSC benchmark suite are famous HEP benchmark programs for this purpose. The CERN suite includes event reconstruction and event generator programs, while the SSC one includes event generators. In this paper, we found that the results from these two suites are not consistent. And, the result from the industry benchmark does not agree with either of these two. Besides, we describe comparison of benchmark results using EGS4 Monte Carlo simulation program with ones from two HEP benchmark suites. Then, we found that the result from EGS4 in not consistent with the two ones. The industry standard of SPECmark values on various computer systems are not consistent with the EGS4 results either. Because of these inconsistencies, we point out the necessity of a standardization of HEP benchmark suites. Also, EGS4 benchmark suite should be developed for users of applications such as medical science, nuclear power plant, nuclear physics and high energy physics. (author)

Depletion benchmarks calculation of random media using explicit modeling approach of RMC

International Nuclear Information System (INIS)

Liu, Shichang; She, Ding; Liang, Jin-gang; Wang, Kan

2016-01-01

Highlights: • Explicit modeling of RMC is applied to depletion benchmark for HTGR fuel element. • Explicit modeling can provide detailed burnup distribution and burnup heterogeneity. • The results would serve as a supplement for the HTGR fuel depletion benchmark. • The method of adjacent burnup regions combination is proposed for full-core problems. • The combination method can reduce memory footprint, keeping the computing accuracy. - Abstract: Monte Carlo method plays an important role in accurate simulation of random media, owing to its advantages of the flexible geometry modeling and the use of continuous-energy nuclear cross sections. Three stochastic geometry modeling methods including Random Lattice Method, Chord Length Sampling and explicit modeling approach with mesh acceleration technique, have been implemented in RMC to simulate the particle transport in the dispersed fuels, in which the explicit modeling method is regarded as the best choice. In this paper, the explicit modeling method is applied to the depletion benchmark for HTGR fuel element, and the method of combination of adjacent burnup regions has been proposed and investigated. The results show that the explicit modeling can provide detailed burnup distribution of individual TRISO particles, and this work would serve as a supplement for the HTGR fuel depletion benchmark calculations. The combination of adjacent burnup regions can effectively reduce the memory footprint while keeping the computational accuracy.

Benchmarking Tool Kit.

Science.gov (United States)

Canadian Health Libraries Association.

Nine Canadian health libraries participated in a pilot test of the Benchmarking Tool Kit between January and April, 1998. Although the Tool Kit was designed specifically for health libraries, the content and approach are useful to other types of libraries as well. Used to its full potential, benchmarking can provide a common measuring stick to…

Integral Full Core Multi-Physics PWR Benchmark with Measured Data

Energy Technology Data Exchange (ETDEWEB)

Forget, Benoit; Smith, Kord; Kumar, Shikhar; Rathbun, Miriam; Liang, Jingang

2018-04-11

In recent years, the importance of modeling and simulation has been highlighted extensively in the DOE research portfolio with concrete examples in nuclear engineering with the CASL and NEAMS programs. These research efforts and similar efforts worldwide aim at the development of high-fidelity multi-physics analysis tools for the simulation of current and next-generation nuclear power reactors. Like all analysis tools, verification and validation is essential to guarantee proper functioning of the software and methods employed. The current approach relies mainly on the validation of single physic phenomena (e.g. critical experiment, flow loops, etc.) and there is a lack of relevant multiphysics benchmark measurements that are necessary to validate high-fidelity methods being developed today. This work introduces a new multi-cycle full-core Pressurized Water Reactor (PWR) depletion benchmark based on two operational cycles of a commercial nuclear power plant that provides a detailed description of fuel assemblies, burnable absorbers, in-core fission detectors, core loading and re-loading patterns. This benchmark enables analysts to develop extremely detailed reactor core models that can be used for testing and validation of coupled neutron transport, thermal-hydraulics, and fuel isotopic depletion. The benchmark also provides measured reactor data for Hot Zero Power (HZP) physics tests, boron letdown curves, and three-dimensional in-core flux maps from 58 instrumented assemblies. The benchmark description is now available online and has been used by many groups. However, much work remains to be done on the quantification of uncertainties and modeling sensitivities. This work aims to address these deficiencies and make this benchmark a true non-proprietary international benchmark for the validation of high-fidelity tools. This report details the BEAVRS uncertainty quantification for the first two cycle of operations and serves as the final report of the project.

OECD/NEA benchmark for time-dependent neutron transport calculations without spatial homogenization

Energy Technology Data Exchange (ETDEWEB)

Hou, Jason, E-mail: jason.hou@ncsu.edu [Department of Nuclear Engineering, North Carolina State University, Raleigh, NC 27695 (United States); Ivanov, Kostadin N. [Department of Nuclear Engineering, North Carolina State University, Raleigh, NC 27695 (United States); Boyarinov, Victor F.; Fomichenko, Peter A. [National Research Centre “Kurchatov Institute”, Kurchatov Sq. 1, Moscow (Russian Federation)

2017-06-15

Highlights: • A time-dependent homogenization-free neutron transport benchmark was created. • The first phase, known as the kinetics phase, was described in this work. • Preliminary results for selected 2-D transient exercises were presented. - Abstract: A Nuclear Energy Agency (NEA), Organization for Economic Co-operation and Development (OECD) benchmark for the time-dependent neutron transport calculations without spatial homogenization has been established in order to facilitate the development and assessment of numerical methods for solving the space-time neutron kinetics equations. The benchmark has been named the OECD/NEA C5G7-TD benchmark, and later extended with three consecutive phases each corresponding to one modelling stage of the multi-physics transient analysis of the nuclear reactor core. This paper provides a detailed introduction of the benchmark specification of Phase I, known as the “kinetics phase”, including the geometry description, supporting neutron transport data, transient scenarios in both two-dimensional (2-D) and three-dimensional (3-D) configurations, as well as the expected output parameters from the participants. Also presented are the preliminary results for the initial state 2-D core and selected transient exercises that have been obtained using the Monte Carlo method and the Surface Harmonic Method (SHM), respectively.

Feasibility of CBCT-based dose calculation: Comparative analysis of HU adjustment techniques

International Nuclear Information System (INIS)

Fotina, Irina; Hopfgartner, Johannes; Stock, Markus; Steininger, Thomas; Lütgendorf-Caucig, Carola; Georg, Dietmar

2012-01-01

Background and purpose: The aim of this work was to compare the accuracy of different HU adjustments for CBCT-based dose calculation. Methods and materials: Dose calculation was performed on CBCT images of 30 patients. In the first two approaches phantom-based (Pha-CC) and population-based (Pop-CC) conversion curves were used. The third method (WAB) represents override of the structures with standard densities for water, air and bone. In ROI mapping approach all structures were overridden with average HUs from planning CT. All techniques were benchmarked to the Pop-CC and CT-based plans by DVH comparison and γ-index analysis. Results: For prostate plans, WAB and ROI mapping compared to Pop-CC showed differences in PTV D median below 2%. The WAB and Pha-CC methods underestimated the bladder dose in IMRT plans. In lung cases PTV coverage was underestimated by Pha-CC method by 2.3% and slightly overestimated by the WAB and ROI techniques. The use of the Pha-CC method for head–neck IMRT plans resulted in difference in PTV coverage up to 5%. Dose calculation with WAB and ROI techniques showed better agreement with pCT than conversion curve-based approaches. Conclusions: Density override techniques provide an accurate alternative to the conversion curve-based methods for dose calculation on CBCT images.

Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort.

Science.gov (United States)

Rager, Julia E; Auerbach, Scott S; Chappell, Grace A; Martin, Elizabeth; Thompson, Chad M; Fry, Rebecca C

2017-10-16

Prenatal inorganic arsenic (iAs) exposure influences the expression of critical genes and proteins associated with adverse outcomes in newborns, in part through epigenetic mediators. The doses at which these genomic and epigenomic changes occur have yet to be evaluated in the context of dose-response modeling. The goal of the present study was to estimate iAs doses that correspond to changes in transcriptomic, proteomic, epigenomic, and integrated multi-omic signatures in human cord blood through benchmark dose (BMD) modeling. Genome-wide DNA methylation, microRNA expression, mRNA expression, and protein expression levels in cord blood were modeled against total urinary arsenic (U-tAs) levels from pregnant women exposed to varying levels of iAs. Dose-response relationships were modeled in BMDExpress, and BMDs representing 10% response levels were estimated. Overall, DNA methylation changes were estimated to occur at lower exposure concentrations in comparison to other molecular endpoints. Multi-omic module eigengenes were derived through weighted gene co-expression network analysis, representing co-modulated signatures across transcriptomic, proteomic, and epigenomic profiles. One module eigengene was associated with decreased gestational age occurring alongside increased iAs exposure. Genes/proteins within this module eigengene showed enrichment for organismal development, including potassium voltage-gated channel subfamily Q member 1 (KCNQ1), an imprinted gene showing differential methylation and expression in response to iAs. Modeling of this prioritized multi-omic module eigengene resulted in a BMD(BMDL) of 58(45) μg/L U-tAs, which was estimated to correspond to drinking water arsenic concentrations of 51(40) μg/L. Results are in line with epidemiological evidence supporting effects of prenatal iAs occurring at levels iAs exposure influences neonatal outcome-relevant transcriptomic, proteomic, and epigenomic profiles.

Benchmark experiments of dose distributions in phantom placed behind iron and concrete shields at the TIARA facility

International Nuclear Information System (INIS)

Nakane, Yoshihiro; Sakamoto, Yukio; Tsuda, Shuichi

2004-01-01

To verify the calculation methods used for the evaluations of neutron dose at the radiation shielding design of the high-intensity proton accelerator facility (J-PARC), dose distributions in a plastic phantom of 30x30x30 cm 3 slab placed behind iron and concrete test shields were measured by using a tissue equivalent proportional counter for 65-MeV quasi-monoenergetic neutrons generated from the 7 Li(p,n) reactions with 68-MeV protons at the TIARA facility. Dose distributions in the phantom were calculated by using the MCNPX and the NMTC/JAM-MCNP codes with the flux-to-dose conversion coefficients prepared for the shielding design of the facility. The comparison results show the calculated results were in good agreement with the measured ones within 20%. (author)

A Global Vision over Benchmarking Process: Benchmarking Based Enterprises

OpenAIRE

Sitnikov, Catalina; Giurca Vasilescu, Laura

2008-01-01

Benchmarking uses the knowledge and the experience of others to improve the enterprise. Starting from the analysis of the performance and underlying the strengths and weaknesses of the enterprise it should be assessed what must be done in order to improve its activity. Using benchmarking techniques, an enterprise looks at how processes in the value chain are performed. The approach based on the vision “from the whole towards the parts” (a fragmented image of the enterprise’s value chain) redu...

Simplified method for creating a density-absorbed dose calibration curve for the low dose range from Gafchromic EBT3 film

Directory of Open Access Journals (Sweden)

Tatsuhiro Gotanda

2016-01-01

Full Text Available Radiochromic film dosimeters have a disadvantage in comparison with an ionization chamber in that the dosimetry process is time-consuming for creating a density-absorbed dose calibration curve. The purpose of this study was the development of a simplified method of creating a density-absorbed dose calibration curve from radiochromic film within a short time. This simplified method was performed using Gafchromic EBT3 film with a low energy dependence and step-shaped Al filter. The simplified method was compared with the standard method. The density-absorbed dose calibration curves created using the simplified and standard methods exhibited approximately similar straight lines, and the gradients of the density-absorbed dose calibration curves were −32.336 and −33.746, respectively. The simplified method can obtain calibration curves within a much shorter time compared to the standard method. It is considered that the simplified method for EBT3 film offers a more time-efficient means of determining the density-absorbed dose calibration curve within a low absorbed dose range such as the diagnostic range.

A BENCHMARK PROGRAM FOR EVALUATION OF METHODS FOR COMPUTING SEISMIC RESPONSE OF COUPLED BUILDING-PIPING/EQUIPMENT WITH NON-CLASSICAL DAMPING

International Nuclear Information System (INIS)

Xu, J.; Degrassi, G.; Chokshi, N.

2001-01-01

Under the auspices of the US Nuclear Regulatory Commission (NRC), Brookhaven National Laboratory (BNL) developed a comprehensive program to evaluate state-of-the-art methods and computer programs for seismic analysis of typical coupled nuclear power plant (NPP) systems with nonclassical damping. In this program, four benchmark models of coupled building-piping/equipment systems with different damping characteristics were analyzed for a suite of earthquakes by program participants applying their uniquely developed methods and computer programs. This paper presents the results of their analyses, and their comparison to the benchmark solutions generated by BNL using time domain direct integration methods. The participant's analysis results established using complex modal time history methods showed good comparison with the BNL solutions, while the analyses produced with either complex-mode response spectrum methods or classical normal-mode response spectrum method, in general, produced more conservative results, when averaged over a suite of earthquakes. However, when coupling due to damping is significant, complex-mode response spectrum methods performed better than the classical normal-mode response spectrum method. Furthermore, as part of the program objectives, a parametric assessment is also presented in this paper, aimed at evaluation of the applicability of various analysis methods to problems with different dynamic characteristics unique to coupled NPP systems. It is believed that the findings and insights learned from this program will be useful in developing new acceptance criteria and providing guidance for future regulatory activities involving licensing applications of these alternate methods to coupled systems

Calculation method for gamma dose rates from Gaussian puffs

Energy Technology Data Exchange (ETDEWEB)

Thykier-Nielsen, S; Deme, S; Lang, E

1995-06-01

The Lagrangian puff models are widely used for calculation of the dispersion of releases to the atmosphere. Basic output from such models is concentration of material in the air and on the ground. The most simple method for calculation of the gamma dose from the concentration of airborne activity is based on the semi-infinite cloud model. This method is however only applicable for puffs with large dispersion parameters, i.e. for receptors far away from the release point. The exact calculation of the cloud dose using volume integral requires large computer time usually exceeding what is available for real time calculations. The volume integral for gamma doses could be approximated by using the semi-infinite cloud model combined with correction factors. This type of calculation procedure is very fast, but usually the accuracy is poor because only a few of the relevant parameters are considered. A multi-parameter method for calculation of gamma doses is described here. This method uses precalculated values of the gamma dose rates as a function of E{sub {gamma}}, {sigma}{sub y}, the asymmetry factor - {sigma}{sub y}/{sigma}{sub z}, the height of puff center - H and the distance from puff center R{sub xy}. To accelerate the calculations the release energy, for each significant radionuclide in each energy group, has been calculated and tabulated. Based on the precalculated values and suitable interpolation procedure the calculation of gamma doses needs only short computing time and it is almost independent of the number of radionuclides considered. (au) 2 tabs., 15 ills., 12 refs.

Calculation method for gamma dose rates from Gaussian puffs

International Nuclear Information System (INIS)

Thykier-Nielsen, S.; Deme, S.; Lang, E.

1995-06-01

The Lagrangian puff models are widely used for calculation of the dispersion of releases to the atmosphere. Basic output from such models is concentration of material in the air and on the ground. The most simple method for calculation of the gamma dose from the concentration of airborne activity is based on the semi-infinite cloud model. This method is however only applicable for puffs with large dispersion parameters, i.e. for receptors far away from the release point. The exact calculation of the cloud dose using volume integral requires large computer time usually exceeding what is available for real time calculations. The volume integral for gamma doses could be approximated by using the semi-infinite cloud model combined with correction factors. This type of calculation procedure is very fast, but usually the accuracy is poor because only a few of the relevant parameters are considered. A multi-parameter method for calculation of gamma doses is described here. This method uses precalculated values of the gamma dose rates as a function of E γ , σ y , the asymmetry factor - σ y /σ z , the height of puff center - H and the distance from puff center R xy . To accelerate the calculations the release energy, for each significant radionuclide in each energy group, has been calculated and tabulated. Based on the precalculated values and suitable interpolation procedure the calculation of gamma doses needs only short computing time and it is almost independent of the number of radionuclides considered. (au) 2 tabs., 15 ills., 12 refs

Application of the hybrid approach to the benchmark dose of urinary cadmium as the reference level for renal effects in cadmium polluted and non-polluted areas in Japan

International Nuclear Information System (INIS)

Suwazono, Yasushi; Nogawa, Kazuhiro; Uetani, Mirei; Nakada, Satoru; Kido, Teruhiko; Nakagawa, Hideaki

2011-01-01

Objectives: The aim of this study was to evaluate the reference level of urinary cadmium (Cd) that caused renal effects. An updated hybrid approach was used to estimate the benchmark doses (BMDs) and their 95% lower confidence limits (BMDL) in subjects with a wide range of exposure to Cd. Methods: The total number of subjects was 1509 (650 men and 859 women) in non-polluted areas and 3103 (1397 men and 1706 women) in the environmentally exposed Kakehashi river basin. We measured urinary cadmium (U-Cd) as a marker of long-term exposure, and β2-microglobulin (β2-MG) as a marker of renal effects. The BMD and BMDL that corresponded to an additional risk (BMR) of 5% were calculated with background risk at zero exposure set at 5%. Results: The U-Cd BMDL for β2-MG was 3.5 μg/g creatinine in men and 3.7 μg/g creatinine in women. Conclusions: The BMDL values for a wide range of U-Cd were generally within the range of values measured in non-polluted areas in Japan. This indicated that the hybrid approach is a robust method for different ranges of cadmium exposure. The present results may contribute further to recent discussions on health risk assessment of Cd exposure.

Application of the hybrid approach to the benchmark dose of urinary cadmium as the reference level for renal effects in cadmium polluted and non-polluted areas in Japan

Energy Technology Data Exchange (ETDEWEB)

Suwazono, Yasushi, E-mail: suwa@faculty.chiba-u.jp [Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba 260-8670 (Japan); Nogawa, Kazuhiro; Uetani, Mirei [Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoku, Chiba 260-8670 (Japan); Nakada, Satoru [Safety and Health Organization, Chiba University, 1-33 Yayoicho, Inageku, Chiba 263-8522 (Japan); Kido, Teruhiko [Department of Community Health Nursing, Kanazawa University School of Health Sciences, 5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942 (Japan); Nakagawa, Hideaki [Department of Epidemiology and Public Health, Kanazawa Medical University, 1-1 Daigaku, Uchnada, Ishikawa 920-0293 (Japan)

2011-02-15

Objectives: The aim of this study was to evaluate the reference level of urinary cadmium (Cd) that caused renal effects. An updated hybrid approach was used to estimate the benchmark doses (BMDs) and their 95% lower confidence limits (BMDL) in subjects with a wide range of exposure to Cd. Methods: The total number of subjects was 1509 (650 men and 859 women) in non-polluted areas and 3103 (1397 men and 1706 women) in the environmentally exposed Kakehashi river basin. We measured urinary cadmium (U-Cd) as a marker of long-term exposure, and {beta}2-microglobulin ({beta}2-MG) as a marker of renal effects. The BMD and BMDL that corresponded to an additional risk (BMR) of 5% were calculated with background risk at zero exposure set at 5%. Results: The U-Cd BMDL for {beta}2-MG was 3.5 {mu}g/g creatinine in men and 3.7 {mu}g/g creatinine in women. Conclusions: The BMDL values for a wide range of U-Cd were generally within the range of values measured in non-polluted areas in Japan. This indicated that the hybrid approach is a robust method for different ranges of cadmium exposure. The present results may contribute further to recent discussions on health risk assessment of Cd exposure.

Calculation method for gamma-dose rates from spherical puffs

International Nuclear Information System (INIS)

Thykier-Nielsen, S.; Deme, S.; Lang, E.

1993-05-01

The Lagrangian puff-models are widely used for calculation of the dispersion of atmospheric releases. Basic output from such models are concentrations of material in the air and on the ground. The most simple method for calculation of the gamma dose from the concentration of airborne activity is based on semi-infinite cloud model. This method is however only applicable for points far away from the release point. The exact calculation of the cloud dose using the volume integral requires significant computer time. The volume integral for the gamma dose could be approximated by using the semi-infinite cloud model combined with correction factors. This type of calculation procedure is very fast, but usually the accuracy is poor due to the fact that the same correction factors are used for all isotopes. The authors describe a more elaborate correction method. This method uses precalculated values of the gamma-dose rate as a function of the puff dispersion parameter (δ p ) and the distance from the puff centre for four energy groups. The release of energy for each radionuclide in each energy group has been calculated and tabulated. Based on these tables and a suitable interpolation procedure the calculation of gamma doses takes very short time and is almost independent of the number of radionuclides. (au) (7 tabs., 7 ills., 12 refs.)

A unique manual method for emergency offsite dose calculations

International Nuclear Information System (INIS)

Wildner, T.E.; Carson, B.H.; Shank, K.E.

1987-01-01

This paper describes a manual method developed for performance of emergency offsite dose calculations for PP and L's Susquehanna Steam Electric Station. The method is based on a three-part carbonless form. The front page guides the user through selection of the appropriate accident case and inclusion of meteorological and effluent data data. By circling the applicable accident descriptors, the user circles the dose factors on pages 2 and 3 which are then simply multiplied to yield the whole body and thyroid dose rates at the plant boundary, two, five, and ten miles. The process used to generate the worksheet is discussed, including the method used to incorporate the observed terrain effects on airflow patterns caused by the Susquehanna River Valley topography

Radiological benchmarks for screening contaminants of potential concern for effects on aquatic biota at Oak Ridge National Laboratory, Oak Ridge, Tennessee

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-07-01

A hazardous waste site may contain hundreds of contaminants; therefore, it is important to screen contaminants of potential concern for the ecological risk assessment. Often this screening is done as part of a screening assessment, the purpose of which is to evaluate the available data, identify data gaps, and screen contaminants of potential concern. Screening may be accomplished by using a set of toxicological benchmarks. These benchmarks are helpful in determining whether contaminants warrant further assessment or are at a level that requires no further attention. Unlike exposures to chemicals, which are expressed as the concentration in water or sediment, exposures to radionuclides are expressed as the dose rate received by the organism. The recommended acceptable dose rate to natural populations of aquatic biota is 1 rad d{sup {minus}1}. Blaylock, Frank, and O`Neal provide formulas and exposure factors for estimating the dose rates to representative aquatic organisms. Those formulas were used herein to calculate the water and sediment concentrations that result in a total dose rate of 1 rad d{sup {minus}1} to fish for selected radionuclides. These radiological benchmarks are intended for use at the US Department of Energy`s (DOE`s) Oak Ridge Reservation and at the Portsmouth and Paducah gaseous diffusion plants as screening values only to show the nature and extent of contamination and identify the need for additional site-specific investigation.

Radiological benchmarks for screening contaminants of potential concern for effects on aquatic biota at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1998-07-01

A hazardous waste site may contain hundreds of contaminants; therefore, it is important to screen contaminants of potential concern for the ecological risk assessment. Often this screening is done as part of a screening assessment, the purpose of which is to evaluate the available data, identify data gaps, and screen contaminants of potential concern. Screening may be accomplished by using a set of toxicological benchmarks. These benchmarks are helpful in determining whether contaminants warrant further assessment or are at a level that requires no further attention. Unlike exposures to chemicals, which are expressed as the concentration in water or sediment, exposures to radionuclides are expressed as the dose rate received by the organism. The recommended acceptable dose rate to natural populations of aquatic biota is 1 rad d -1 . Blaylock, Frank, and O'Neal provide formulas and exposure factors for estimating the dose rates to representative aquatic organisms. Those formulas were used herein to calculate the water and sediment concentrations that result in a total dose rate of 1 rad d -1 to fish for selected radionuclides. These radiological benchmarks are intended for use at the US Department of Energy's (DOE's) Oak Ridge Reservation and at the Portsmouth and Paducah gaseous diffusion plants as screening values only to show the nature and extent of contamination and identify the need for additional site-specific investigation

Argonne Code Center: Benchmark problem book.

Energy Technology Data Exchange (ETDEWEB)

None, None

1977-06-01

This book is an outgrowth of activities of the Computational Benchmark Problems Committee of the Mathematics and Computation Division of the American Nuclear Society. This is the second supplement of the original benchmark book which was first published in February, 1968 and contained computational benchmark problems in four different areas. Supplement No. 1, which was published in December, 1972, contained corrections to the original benchmark book plus additional problems in three new areas. The current supplement. Supplement No. 2, contains problems in eight additional new areas. The objectives of computational benchmark work and the procedures used by the committee in pursuing the objectives are outlined in the original edition of the benchmark book (ANL-7416, February, 1968). The members of the committee who have made contributions to Supplement No. 2 are listed below followed by the contributors to the earlier editions of the benchmark book.

NetBenchmark: a bioconductor package for reproducible benchmarks of gene regulatory network inference.

Science.gov (United States)

Bellot, Pau; Olsen, Catharina; Salembier, Philippe; Oliveras-Vergés, Albert; Meyer, Patrick E

2015-09-29

In the last decade, a great number of methods for reconstructing gene regulatory networks from expression data have been proposed. However, very few tools and datasets allow to evaluate accurately and reproducibly those methods. Hence, we propose here a new tool, able to perform a systematic, yet fully reproducible, evaluation of transcriptional network inference methods. Our open-source and freely available Bioconductor package aggregates a large set of tools to assess the robustness of network inference algorithms against different simulators, topologies, sample sizes and noise intensities. The benchmarking framework that uses various datasets highlights the specialization of some methods toward network types and data. As a result, it is possible to identify the techniques that have broad overall performances.

[Benchmarking and other functions of ROM: back to basics].

Science.gov (United States)

Barendregt, M

2015-01-01

Since 2011 outcome data in the Dutch mental health care have been collected on a national scale. This has led to confusion about the position of benchmarking in the system known as routine outcome monitoring (rom). To provide insight into the various objectives and uses of aggregated outcome data. A qualitative review was performed and the findings were analysed. Benchmarking is a strategy for finding best practices and for improving efficacy and it belongs to the domain of quality management. Benchmarking involves comparing outcome data by means of instrumentation and is relatively tolerant with regard to the validity of the data. Although benchmarking is a function of rom, it must be differentiated form other functions from rom. Clinical management, public accountability, research, payment for performance and information for patients are all functions of rom which require different ways of data feedback and which make different demands on the validity of the underlying data. Benchmarking is often wrongly regarded as being simply a synonym for 'comparing institutions'. It is, however, a method which includes many more factors; it can be used to improve quality and has a more flexible approach to the validity of outcome data and is less concerned than other rom functions about funding and the amount of information given to patients. Benchmarking can make good use of currently available outcome data.

Benchmarks for GADRAS performance validation

International Nuclear Information System (INIS)

Mattingly, John K.; Mitchell, Dean James; Rhykerd, Charles L. Jr.

2009-01-01

The performance of the Gamma Detector Response and Analysis Software (GADRAS) was validated by comparing GADRAS model results to experimental measurements for a series of benchmark sources. Sources for the benchmark include a plutonium metal sphere, bare and shielded in polyethylene, plutonium oxide in cans, a highly enriched uranium sphere, bare and shielded in polyethylene, a depleted uranium shell and spheres, and a natural uranium sphere. The benchmark experimental data were previously acquired and consist of careful collection of background and calibration source spectra along with the source spectra. The calibration data were fit with GADRAS to determine response functions for the detector in each experiment. A one-dimensional model (pie chart) was constructed for each source based on the dimensions of the benchmark source. The GADRAS code made a forward calculation from each model to predict the radiation spectrum for the detector used in the benchmark experiment. The comparisons between the GADRAS calculation and the experimental measurements are excellent, validating that GADRAS can correctly predict the radiation spectra for these well-defined benchmark sources.

Benchmarking in Czech Higher Education

Directory of Open Access Journals (Sweden)

Plaček Michal

2015-12-01

Full Text Available The first part of this article surveys the current experience with the use of benchmarking at Czech universities specializing in economics and management. The results indicate that collaborative benchmarking is not used on this level today, but most actors show some interest in its introduction. The expression of the need for it and the importance of benchmarking as a very suitable performance-management tool in less developed countries are the impetus for the second part of our article. Based on an analysis of the current situation and existing needs in the Czech Republic, as well as on a comparison with international experience, recommendations for public policy are made, which lie in the design of a model of a collaborative benchmarking for Czech economics and management in higher-education programs. Because the fully complex model cannot be implemented immediately – which is also confirmed by structured interviews with academics who have practical experience with benchmarking –, the final model is designed as a multi-stage model. This approach helps eliminate major barriers to the implementation of benchmarking.

Extraction of electron beam dose parameters from EBT2 film data scored in a mini phantom.

Science.gov (United States)

O'Reilly, Dedri; Smit, Cobus J L; du Plessis, Freek C P

2013-09-01

Quality assurance of medical linear accelerators includes dosimetric parameter measurement of therapeutic electron beams e.g. relative dose at a depth of 80% (R₈₀). This parameter must be within a tolerance of 0.2 cm of the declared value. Cumbersome water tank measurements can be regarded as a benchmark to measure electron depth dose curves. A mini-phantom was designed and built, in which a strip of GAFCHROMIC® EBT2 film could be encased tightly for electron beam depth dose measurement. Depth dose data were measured for an ELEKTA Sl25 MLC, ELEKTA Precise, and ELEKTA Synergy (Elekta Oncology Systems, Crawley, UK) machines. The electron beam energy range was between 4 and 22 MeV among the machines. A 10 × 10 cm² electron applicator with 95 cm source-surface-distance was used on all the machines. 24 h after irradiation, the EBT2 film strips were scanned on Canon CanoScan N670U scanner. Afterwards, the data were analysed with in-house developed software that entailed optical density to dose conversion, and optimal fitting of the PDD data to de-noise the raw data. From the PDD data R₈₀ values were solved for and compared with acceptance values. A series of tests were also carried out to validate the use of the scanner for film Dosimetry. These tests are presented in this study. It was found that this method of R₈₀ evaluation was reliable with good agreement with benchmark water tank measurements using a commercial parallel plate ionization chamber as the radiation detector. The EBT2 film data yielded R₈₀ values that were on average 0.06 cm different from benchmark water tank measured R₈₀ values.

Benchmark calculations of power distribution within assemblies

International Nuclear Information System (INIS)

Cavarec, C.; Perron, J.F.; Verwaerde, D.; West, J.P.

1994-09-01

The main objective of this Benchmark is to compare different techniques for fine flux prediction based upon coarse mesh diffusion or transport calculations. We proposed 5 ''core'' configurations including different assembly types (17 x 17 pins, ''uranium'', ''absorber'' or ''MOX'' assemblies), with different boundary conditions. The specification required results in terms of reactivity, pin by pin fluxes and production rate distributions. The proposal for these Benchmark calculations was made by J.C. LEFEBVRE, J. MONDOT, J.P. WEST and the specification (with nuclear data, assembly types, core configurations for 2D geometry and results presentation) was distributed to correspondents of the OECD Nuclear Energy Agency. 11 countries and 19 companies answered the exercise proposed by this Benchmark. Heterogeneous calculations and homogeneous calculations were made. Various methods were used to produce the results: diffusion (finite differences, nodal...), transport (P ij , S n , Monte Carlo). This report presents an analysis and intercomparisons of all the results received

Benchmark calculations of power distribution within fuel assemblies. Phase 2: comparison of data reduction and power reconstruction methods in production codes

International Nuclear Information System (INIS)

2000-01-01

Systems loaded with plutonium in the form of mixed-oxide (MOX) fuel show somewhat different neutronic characteristics compared with those using conventional uranium fuels. In order to maintain adequate safety standards, it is essential to accurately predict the characteristics of MOX-fuelled systems and to further validate both the nuclear data and the computation methods used. A computation benchmark on power distribution within fuel assemblies to compare different techniques used in production codes for fine flux prediction in systems partially loaded with MOX fuel was carried out at an international level. It addressed first the numerical schemes for pin power reconstruction, then investigated the global performance including cross-section data reduction methods. This report provides the detailed results of this second phase of the benchmark. The analysis of the results revealed that basic data still need to be improved, primarily for higher plutonium isotopes and minor actinides. (author)

Molecular Line Emission from Multifluid Shock Waves. I. Numerical Methods and Benchmark Tests

Science.gov (United States)

Ciolek, Glenn E.; Roberge, Wayne G.

2013-05-01

We describe a numerical scheme for studying time-dependent, multifluid, magnetohydrodynamic shock waves in weakly ionized interstellar clouds and cores. Shocks are modeled as propagating perpendicular to the magnetic field and consist of a neutral molecular fluid plus a fluid of ions and electrons. The scheme is based on operator splitting, wherein time integration of the governing equations is split into separate parts. In one part, independent homogeneous Riemann problems for the two fluids are solved using Godunov's method. In the other, equations containing the source terms for transfer of mass, momentum, and energy between the fluids are integrated using standard numerical techniques. We show that, for the frequent case where the thermal pressures of the ions and electrons are Lt magnetic pressure, the Riemann problems for the neutral and ion-electron fluids have a similar mathematical structure which facilitates numerical coding. Implementation of the scheme is discussed and several benchmark tests confirming its accuracy are presented, including (1) MHD wave packets ranging over orders of magnitude in length- and timescales, (2) early evolution of multifluid shocks caused by two colliding clouds, and (3) a multifluid shock with mass transfer between the fluids by cosmic-ray ionization and ion-electron recombination, demonstrating the effect of ion mass loading on magnetic precursors of MHD shocks. An exact solution to an MHD Riemann problem forming the basis for an approximate numerical solver used in the homogeneous part of our scheme is presented, along with derivations of the analytic benchmark solutions and tests showing the convergence of the numerical algorithm.

MOLECULAR LINE EMISSION FROM MULTIFLUID SHOCK WAVES. I. NUMERICAL METHODS AND BENCHMARK TESTS

International Nuclear Information System (INIS)

Ciolek, Glenn E.; Roberge, Wayne G.

2013-01-01

We describe a numerical scheme for studying time-dependent, multifluid, magnetohydrodynamic shock waves in weakly ionized interstellar clouds and cores. Shocks are modeled as propagating perpendicular to the magnetic field and consist of a neutral molecular fluid plus a fluid of ions and electrons. The scheme is based on operator splitting, wherein time integration of the governing equations is split into separate parts. In one part, independent homogeneous Riemann problems for the two fluids are solved using Godunov's method. In the other, equations containing the source terms for transfer of mass, momentum, and energy between the fluids are integrated using standard numerical techniques. We show that, for the frequent case where the thermal pressures of the ions and electrons are << magnetic pressure, the Riemann problems for the neutral and ion-electron fluids have a similar mathematical structure which facilitates numerical coding. Implementation of the scheme is discussed and several benchmark tests confirming its accuracy are presented, including (1) MHD wave packets ranging over orders of magnitude in length- and timescales, (2) early evolution of multifluid shocks caused by two colliding clouds, and (3) a multifluid shock with mass transfer between the fluids by cosmic-ray ionization and ion-electron recombination, demonstrating the effect of ion mass loading on magnetic precursors of MHD shocks. An exact solution to an MHD Riemann problem forming the basis for an approximate numerical solver used in the homogeneous part of our scheme is presented, along with derivations of the analytic benchmark solutions and tests showing the convergence of the numerical algorithm.

International benchmarking of specialty hospitals. A series of case studies on comprehensive cancer centres

Science.gov (United States)

2010-01-01

Background Benchmarking is one of the methods used in business that is applied to hospitals to improve the management of their operations. International comparison between hospitals can explain performance differences. As there is a trend towards specialization of hospitals, this study examines the benchmarking process and the success factors of benchmarking in international specialized cancer centres. Methods Three independent international benchmarking studies on operations management in cancer centres were conducted. The first study included three comprehensive cancer centres (CCC), three chemotherapy day units (CDU) were involved in the second study and four radiotherapy departments were included in the final study. Per multiple case study a research protocol was used to structure the benchmarking process. After reviewing the multiple case studies, the resulting description was used to study the research objectives. Results We adapted and evaluated existing benchmarking processes through formalizing stakeholder involvement and verifying the comparability of the partners. We also devised a framework to structure the indicators to produce a coherent indicator set and better improvement suggestions. Evaluating the feasibility of benchmarking as a tool to improve hospital processes led to mixed results. Case study 1 resulted in general recommendations for the organizations involved. In case study 2, the combination of benchmarking and lean management led in one CDU to a 24% increase in bed utilization and a 12% increase in productivity. Three radiotherapy departments of case study 3, were considering implementing the recommendations. Additionally, success factors, such as a well-defined and small project scope, partner selection based on clear criteria, stakeholder involvement, simple and well-structured indicators, analysis of both the process and its results and, adapt the identified better working methods to the own setting, were found. Conclusions The improved

ANN-Benchmarks: A Benchmarking Tool for Approximate Nearest Neighbor Algorithms

DEFF Research Database (Denmark)

Aumüller, Martin; Bernhardsson, Erik; Faithfull, Alexander

2017-01-01

This paper describes ANN-Benchmarks, a tool for evaluating the performance of in-memory approximate nearest neighbor algorithms. It provides a standard interface for measuring the performance and quality achieved by nearest neighbor algorithms on different standard data sets. It supports several...... visualise these as images, Open image in new window plots, and websites with interactive plots. ANN-Benchmarks aims to provide a constantly updated overview of the current state of the art of k-NN algorithms. In the short term, this overview allows users to choose the correct k-NN algorithm and parameters...... for their similarity search task; in the longer term, algorithm designers will be able to use this overview to test and refine automatic parameter tuning. The paper gives an overview of the system, evaluates the results of the benchmark, and points out directions for future work. Interestingly, very different...

Toward an organ based dose prescription method for the improved accuracy of murine dose in orthovoltage x-ray irradiators

International Nuclear Information System (INIS)

Belley, Matthew D.; Wang, Chu; Nguyen, Giao; Gunasingha, Rathnayaka; Chao, Nelson J.; Chen, Benny J.; Dewhirst, Mark W.; Yoshizumi, Terry T.

2014-01-01

Purpose: Accurate dosimetry is essential when irradiating mice to ensure that functional and molecular endpoints are well understood for the radiation dose delivered. Conventional methods of prescribing dose in mice involve the use of a single dose rate measurement and assume a uniform average dose throughout all organs of the entire mouse. Here, the authors report the individual average organ dose values for the irradiation of a 12, 23, and 33 g mouse on a 320 kVp x-ray irradiator and calculate the resulting error from using conventional dose prescription methods. Methods: Organ doses were simulated in the Geant4 application for tomographic emission toolkit using the MOBY mouse whole-body phantom. Dosimetry was performed for three beams utilizing filters A (1.65 mm Al), B (2.0 mm Al), and C (0.1 mm Cu + 2.5 mm Al), respectively. In addition, simulated x-ray spectra were validated with physical half-value layer measurements. Results: Average doses in soft-tissue organs were found to vary by as much as 23%–32% depending on the filter. Compared to filters A and B, filter C provided the hardest beam and had the lowest variation in soft-tissue average organ doses across all mouse sizes, with a difference of 23% for the median mouse size of 23 g. Conclusions: This work suggests a new dose prescription method in small animal dosimetry: it presents a departure from the conventional approach of assigninga single dose value for irradiation of mice to a more comprehensive approach of characterizing individual organ doses to minimize the error and uncertainty. In human radiation therapy, clinical treatment planning establishes the target dose as well as the dose distribution, however, this has generally not been done in small animal research. These results suggest that organ dose errors will be minimized by calibrating the dose rates for all filters, and using different dose rates for different organs

Evaluating the Resilience of the Bottom-up Method used to Detect and Benchmark the Smartness of University Campuses

DEFF Research Database (Denmark)

Giovannella, Carlo; Andone, Diana; Dascalu, Mihai

2016-01-01

A new method to perform a bottom-up extraction and benchmark of the perceived multilevel smartness of complex ecosystems has been recently described and applied to territories and learning ecosystems like university campuses and schools. In this paper we study the resilience of our method...... by comparing and integrating the data collected in several European Campuses during two different academic years, 2014-15 and 2015-16. The overall results are: a) a more adequate and robust definition of the orthogonal multidimensional space of representation of the smartness, and b) the definition...

Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD and Multiple Approaches for Selection of Chemical Point of Departure (PoD.

Directory of Open Access Journals (Sweden)

A Francina Webster

Full Text Available Many regulatory agencies are exploring ways to integrate toxicogenomic data into their chemical risk assessments. The major challenge lies in determining how to distill the complex data produced by high-content, multi-dose gene expression studies into quantitative information. It has been proposed that benchmark dose (BMD values derived from toxicogenomics data be used as point of departure (PoD values in chemical risk assessments. However, there is limited information regarding which genomics platforms are most suitable and how to select appropriate PoD values. In this study, we compared BMD values modeled from RNA sequencing-, microarray-, and qPCR-derived gene expression data from a single study, and explored multiple approaches for selecting a single PoD from these data. The strategies evaluated include several that do not require prior mechanistic knowledge of the compound for selection of the PoD, thus providing approaches for assessing data-poor chemicals. We used RNA extracted from the livers of female mice exposed to non-carcinogenic (0, 2 mg/kg/day, mkd and carcinogenic (4, 8 mkd doses of furan for 21 days. We show that transcriptional BMD values were consistent across technologies and highly predictive of the two-year cancer bioassay-based PoD. We also demonstrate that filtering data based on statistically significant changes in gene expression prior to BMD modeling creates more conservative BMD values. Taken together, this case study on mice exposed to furan demonstrates that high-content toxicogenomics studies produce robust data for BMD modelling that are minimally affected by inter-technology variability and highly predictive of cancer-based PoD doses.

Dose Escalation Methods in Phase I Cancer Clinical Trials

OpenAIRE

Le Tourneau, Christophe; Lee, J. Jack; Siu, Lillian L.

2009-01-01

Phase I clinical trials are an essential step in the development of anticancer drugs. The main goal of these studies is to establish the recommended dose and/or schedule of new drugs or drug combinations for phase II trials. The guiding principle for dose escalation in phase I trials is to avoid exposing too many patients to subtherapeutic doses while preserving safety and maintaining rapid accrual. Here we review dose escalation methods for phase I trials, including the rule-based and model-...

Application of benchmark dose modeling to protein expression data in the development and analysis of mode of action/adverse outcome pathways for testicular toxicity.

Science.gov (United States)

Chepelev, Nikolai L; Meek, M E Bette; Yauk, Carole Lyn

2014-11-01

Reliable quantification of gene and protein expression has potential to contribute significantly to the characterization of hypothesized modes of action (MOA) or adverse outcome pathways for critical effects of toxicants. Quantitative analysis of gene expression by benchmark dose (BMD) modeling has been facilitated by the development of effective software tools. In contrast, protein expression is still generally quantified by a less robust effect level (no or lowest [adverse] effect levels) approach, which minimizes its potential utility in the consideration of dose-response and temporal concordance for key events in hypothesized MOAs. BMD modeling is applied here to toxicological data on testicular toxicity to investigate its potential utility in analyzing protein expression relevant to the proposed MOA to inform human health risk assessment. The results illustrate how the BMD analysis of protein expression in animal tissues in response to toxicant exposure: (1) complements other toxicity data, and (2) contributes to consideration of the empirical concordance of dose-response relationships, as part of the weight of evidence for hypothesized MOAs to facilitate consideration and application in regulatory risk assessment. Lack of BMD analysis in proteomics has likely limited its use for these purposes. This paper illustrates the added value of BMD modeling to support and strengthen hypothetical MOAs as a basis to facilitate the translation and uptake of the results of proteomic research into risk assessment. Copyright © 2014 Her Majesty the Queen in Right of Canada. Journal of Applied Toxicology © 2014 John Wiley & Sons, Ltd.

Benchmarking of London Dispersion-Accounting Density Functional Theory Methods on Very Large Molecular Complexes.

Science.gov (United States)

Risthaus, Tobias; Grimme, Stefan

2013-03-12

A new test set (S12L) containing 12 supramolecular noncovalently bound complexes is presented and used to evaluate seven different methods to account for dispersion in DFT (DFT-D3, DFT-D2, DFT-NL, XDM, dDsC, TS-vdW, M06-L) at different basis set levels against experimental, back-corrected reference energies. This allows conclusions about the performance of each method in an explorative research setting on "real-life" problems. Most DFT methods show satisfactory performance but, due to the largeness of the complexes, almost always require an explicit correction for the nonadditive Axilrod-Teller-Muto three-body dispersion interaction to get accurate results. The necessity of using a method capable of accounting for dispersion is clearly demonstrated in that the two-body dispersion contributions are on the order of 20-150% of the total interaction energy. MP2 and some variants thereof are shown to be insufficient for this while a few tested D3-corrected semiempirical MO methods perform reasonably well. Overall, we suggest the use of this benchmark set as a "sanity check" against overfitting to too small molecular cases.

Toxicological benchmarks for screening potential contaminants of concern for effects on terrestrial plants

International Nuclear Information System (INIS)

Suter, G.W. II; Will, M.E.; Evans, C.

1993-09-01

One of the initial stages in ecological risk assessment for hazardous waste sites is the screening of contaminants to determine which of them are worthy of further consideration as ''contaminants of potential concern.'' This process is termed ''contaminant screening.'' It is performed by comparing measured ambient concentrations of chemicals to benchmark concentrations. Currently, no standard benchmark concentrations exist for assessing contaminants in soil with respect to their toxicity to plants. This report presents a standard method for deriving benchmarks for this purpose (phytotoxicity benchmarks), a set of data concerning effects of chemicals in soil or soil solution on plants, and a set of phytotoxicity benchmarks for 34 chemicals potentially associated with US Department of Energy (DOE) sites. Chemicals that are found in soil at concentrations exceeding both the phytotoxicity benchmark and the background concentration for the soil type should be considered contaminants of potential concern. The purpose of this report is to present plant toxicity data and discuss their utility as benchmarks for determining the hazard to terrestrial plants caused by contaminants in soil. Benchmarks are provided for soils and solutions

A Method for Correcting IMRT Optimizer Heterogeneity Dose Calculations

International Nuclear Information System (INIS)

Zacarias, Albert S.; Brown, Mellonie F.; Mills, Michael D.

2010-01-01

Radiation therapy treatment planning for volumes close to the patient's surface, in lung tissue and in the head and neck region, can be challenging for the planning system optimizer because of the complexity of the treatment and protected volumes, as well as striking heterogeneity corrections. Because it is often the goal of the planner to produce an isodose plan with uniform dose throughout the planning target volume (PTV), there is a need for improved planning optimization procedures for PTVs located in these anatomical regions. To illustrate such an improved procedure, we present a treatment planning case of a patient with a lung lesion located in the posterior right lung. The intensity-modulated radiation therapy (IMRT) plan generated using standard optimization procedures produced substantial dose nonuniformity across the tumor caused by the effect of lung tissue surrounding the tumor. We demonstrate a novel iterative method of dose correction performed on the initial IMRT plan to produce a more uniform dose distribution within the PTV. This optimization method corrected for the dose missing on the periphery of the PTV and reduced the maximum dose on the PTV to 106% from 120% on the representative IMRT plan.

A fast dose calculation method based on table lookup for IMRT optimization

International Nuclear Information System (INIS)

Wu Qiuwen; Djajaputra, David; Lauterbach, Marc; Wu Yan; Mohan, Radhe

2003-01-01

This note describes a fast dose calculation method that can be used to speed up the optimization process in intensity-modulated radiotherapy (IMRT). Most iterative optimization algorithms in IMRT require a large number of dose calculations to achieve convergence and therefore the total amount of time needed for the IMRT planning can be substantially reduced by using a faster dose calculation method. The method that is described in this note relies on an accurate dose calculation engine that is used to calculate an approximate dose kernel for each beam used in the treatment plan. Once the kernel is computed and saved, subsequent dose calculations can be done rapidly by looking up this kernel. Inaccuracies due to the approximate nature of the kernel in this method can be reduced by performing scheduled kernel updates. This fast dose calculation method can be performed more than two orders of magnitude faster than the typical superposition/convolution methods and therefore is suitable for applications in which speed is critical, e.g., in an IMRT optimization that requires a simulated annealing optimization algorithm or in a practical IMRT beam-angle optimization system. (note)

A two-dimensional method of manufactured solutions benchmark suite based on variations of Larsen's benchmark with escalating order of smoothness of the exact solution

International Nuclear Information System (INIS)

Schunert, Sebastian; Azmy, Yousry Y.

2011-01-01

The quantification of the discretization error associated with the spatial discretization of the Discrete Ordinate(DO) equations in multidimensional Cartesian geometries is the central problem in error estimation of spatial discretization schemes for transport theory as well as computer code verification. Traditionally ne mesh solutions are employed as reference, because analytical solutions only exist in the absence of scattering. This approach, however, is inadequate when the discretization error associated with the reference solution is not small compared to the discretization error associated with the mesh under scrutiny. Typically this situation occurs if the mesh of interest is only a couple of refinement levels away from the reference solution or if the order of accuracy of the numerical method (and hence the reference as well) is lower than expected. In this work we present a Method of Manufactured Solutions (MMS) benchmark suite with variable order of smoothness of the underlying exact solution for two-dimensional Cartesian geometries which provides analytical solutions aver- aged over arbitrary orthogonal meshes for scattering and non-scattering media. It should be emphasized that the developed MMS benchmark suite rst eliminates the aforementioned limitation of ne mesh reference solutions since it secures knowledge of the underlying true solution and second that it allows for an arbitrary order of smoothness of the underlying ex- act solution. The latter is of importance because even for smooth parameters and boundary conditions the DO equations can feature exact solution with limited smoothness. Moreover, the degree of smoothness is crucial for both the order of accuracy and the magnitude of the discretization error for any spatial discretization scheme. (author)

Fast, three-dimensional, MR Imaging for polymer gel dosimetric applications involving high dose and steep dose gradients

International Nuclear Information System (INIS)

Sandilos, Panagiotis; Baras, Panagiotis; Georgiou, Evangelos; Dardoufas, Konstantinos; Karaiskos, Pantelis; Papagiannis, Panagiotis; Paschalis, Theodoros; Tatsis, Elias; Torrens, Michael; Vlahos, Lampros

2006-01-01

Polymer gels constitute water equivalent integrating detectors, which, combined with magnetic resonance imaging (MRI), can provide accurate three dimensional (3D) dose distributions in contemporary radiotherapy applications where the small field dimensions and steep dose gradients induce limitations to conventional dosimeters. One of the main obstacles for adapting the method for routine use in the clinical setting is the cost effectiveness of the MRI readout method. Currently, optimized Carr-Purcell-Meiboom-Gill (CPMG) multiple spin echo imaging pulse sequences are commonly used which however result in long imaging times. This work evaluates the efficiency of 3D, dual-echo, k-space segmented turbo spin echo (TSE) scanning sequences for accurate dosimetry with sub-millimetre spatial resolution in strenuous radiation therapy applications. PABIG polymer gel dosimeters were irradiated with an 192 Ir High Dose Rate brachytherapy source, the 4 mm and 8 mm collimator helmets of a gamma knife unit and a custom made x-knife collimator of 1 cm diameter. Profile and dose distribution measurements using TSE are benchmarked against corresponding findings obtained by the commonly used, but time consuming, CPMG sequence as well as treatment planning calculations, Monte Carlo (MC) simulations and film measurements. The implementation of a high Turbo factor was found to provide comparable accuracy, allowing a 64-fold MRI scan acceleration compared to conventional multi-echo sequences. The availability of TSE sequences in typical MRI installations greatly facilitates the introduction of polymer gel dosimetry in the clinical environment as a practicable tool for the determination of full 3D dose distributions in contemporary radiotherapy applications

Fast, three-dimensional, MR Imaging for polymer gel dosimetric applications involving high dose and steep dose gradients

Energy Technology Data Exchange (ETDEWEB)

Sandilos, Panagiotis [Department of Radiology, Medical School, University of Athens, Areteion Hospital, 76 Vas. Sofias Ave., 115 28 Athens (Greece); Baras, Panagiotis [Philips Hellas Medical Systems, 44 Kifissias Ave., Maroussi 151 25, Athens (Greece); Georgiou, Evangelos [Medical Physics Department, University of Athens, 75 Mikras Asias, 115 27 Athens (Greece); Dardoufas, Konstantinos [Department of Radiology, Medical School, University of Athens, Areteion Hospital, 76 Vas. Sofias Ave., 115 28 Athens (Greece): Hygeia Hospital, Kiffisias Avenue and 4 Erythrou Stavrou, Marousi, 151 23 Athens (Greece); Karaiskos, Pantelis [Medical Physics Department, University of Athens, 75 Mikras Asias, 115 27 Athens (Greece): Hygeia Hospital, Kiffisias Avenue and 4 Erythrou Stavrou, Marousi, 151 23 Athens (Greece)]. E-mail: p.karaiskos@hygeia.gr; Papagiannis, Panagiotis [Physics Department, Nuclear and Particle Physics Section, University of Athens, Panepistimioupolis, Ilisia, 157 71 Athens (Greece); Paschalis, Theodoros [Department of Radiology, Medical School, University of Athens, Areteion Hospital, 76 Vas. Sofias Ave., 115 28 Athens (Greece); Tatsis, Elias [Department of Radiology, Medical School, University of Athens, Areteion Hospital, 76 Vas. Sofias Ave., 115 28 Athens (Greece); Torrens, Michael [Hygeia Hospital, Kiffisias Avenue and 4 Erythrou Stavrou, Marousi, 151 23 Athens (Greece); Vlahos, Lampros [Department of Radiology, Medical School, University of Athens, Areteion Hospital, 76 Vas. Sofias Ave., 115 28 Athens (Greece)

2006-12-20

Polymer gels constitute water equivalent integrating detectors, which, combined with magnetic resonance imaging (MRI), can provide accurate three dimensional (3D) dose distributions in contemporary radiotherapy applications where the small field dimensions and steep dose gradients induce limitations to conventional dosimeters. One of the main obstacles for adapting the method for routine use in the clinical setting is the cost effectiveness of the MRI readout method. Currently, optimized Carr-Purcell-Meiboom-Gill (CPMG) multiple spin echo imaging pulse sequences are commonly used which however result in long imaging times. This work evaluates the efficiency of 3D, dual-echo, k-space segmented turbo spin echo (TSE) scanning sequences for accurate dosimetry with sub-millimetre spatial resolution in strenuous radiation therapy applications. PABIG polymer gel dosimeters were irradiated with an {sup 192}Ir High Dose Rate brachytherapy source, the 4 mm and 8 mm collimator helmets of a gamma knife unit and a custom made x-knife collimator of 1 cm diameter. Profile and dose distribution measurements using TSE are benchmarked against corresponding findings obtained by the commonly used, but time consuming, CPMG sequence as well as treatment planning calculations, Monte Carlo (MC) simulations and film measurements. The implementation of a high Turbo factor was found to provide comparable accuracy, allowing a 64-fold MRI scan acceleration compared to conventional multi-echo sequences. The availability of TSE sequences in typical MRI installations greatly facilitates the introduction of polymer gel dosimetry in the clinical environment as a practicable tool for the determination of full 3D dose distributions in contemporary radiotherapy applications.

Benchmarking af kommunernes sagsbehandling

DEFF Research Database (Denmark)

Amilon, Anna

Fra 2007 skal Ankestyrelsen gennemføre benchmarking af kommuernes sagsbehandlingskvalitet. Formålet med benchmarkingen er at udvikle praksisundersøgelsernes design med henblik på en bedre opfølgning og at forbedre kommunernes sagsbehandling. Dette arbejdspapir diskuterer metoder for benchmarking...

Method for simulating dose reduction in digital mammography using the Anscombe transformation

OpenAIRE

Borges, Lucas R.; de Oliveira, Helder C. R.; Nunes, Polyana F.; Bakic, Predrag R.; Maidment, Andrew D. A.; Vieira, Marcelo A. C.

2016-01-01

Purpose: This work proposes an accurate method for simulating dose reduction in digital mammography starting from a clinical image acquired with a standard dose. Methods: The method developed in this work consists of scaling a mammogram acquired at the standard radiation dose and adding signal-dependent noise. The algorithm accounts for specific issues relevant in digital mammography images, such as anisotropic noise, spatial variations in pixel gain, and the effect of dose reduction on the d...

Objective method to report planner-independent skin/rib maximal dose in balloon-based high dose rate (HDR) brachytherapy for breast cancer

International Nuclear Information System (INIS)

Kim, Yongbok; Trombetta, Mark G.

2011-01-01

Purpose: An objective method was proposed and compared with a manual selection method to determine planner-independent skin and rib maximal dose in balloon-based high dose rate (HDR) brachytherapy planning. Methods: The maximal dose to skin and rib was objectively extracted from a dose volume histogram (DVH) of skin and rib volumes. A virtual skin volume was produced by expanding the skin surface in three dimensions (3D) external to the breast with a certain thickness in the planning computed tomography (CT) images. Therefore, the maximal dose to this volume occurs on the skin surface the same with a conventional manual selection method. The rib was also delineated in the planning CT images and its maximal dose was extracted from its DVH. The absolute (Abdiff=|D max Man -D max DVH |) and relative (Rediff[%]=100x(|D max Man -D max DVH |)/D max DVH ) maximal skin and rib dose differences between the manual selection method (D max Man ) and the objective method (D max DVH ) were measured for 50 balloon-based HDR (25 MammoSite and 25 Contura) patients. Results: The average±standard deviation of maximal dose difference was 1.67%±1.69% of the prescribed dose (PD). No statistical difference was observed between MammoSite and Contura patients for both Abdiff and Rediff[%] values. However, a statistically significant difference (p value max >90%) compared with lower dose range (D max <90%): 2.16%±1.93% vs 1.19%±1.25% with p value of 0.0049. However, the Rediff[%] analysis eliminated the inverse square factor and there was no statistically significant difference (p value=0.8931) between high and low dose ranges. Conclusions: The objective method using volumetric information of skin and rib can determine the planner-independent maximal dose compared with the manual selection method. However, the difference was <2% of PD, on average, if appropriate attention is paid to selecting a manual dose point in 3D planning CT images.

Radiological environmental dose assessment methods and compliance dose results for 2015 operations at the Savannah River Site

Energy Technology Data Exchange (ETDEWEB)

Jannik, G. T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Dixon, K. L. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2016-09-01

This report presents the environmental dose assessment methods and the estimated potential doses to the offsite public from 2015 Savannah River Site (SRS) atmospheric and liquid radioactive releases. Also documented are potential doses from special-case exposure scenarios - such as the consumption of deer meat, fish, and goat milk.

Radiological environmental dose assessment methods and compliance dose results for 2015 operations at the Savannah River Site

International Nuclear Information System (INIS)

Jannik, G. T.; Dixon, K. L.

2016-01-01

This report presents the environmental dose assessment methods and the estimated potential doses to the offsite public from 2015 Savannah River Site (SRS) atmospheric and liquid radioactive releases. Also documented are potential doses from special-case exposure scenarios - such as the consumption of deer meat, fish, and goat milk.

MFTF TOTAL benchmark

International Nuclear Information System (INIS)

Choy, J.H.

1979-06-01

A benchmark of the TOTAL data base management system as applied to the Mirror Fusion Test Facility (MFTF) data base was implemented and run in February and March of 1979. The benchmark was run on an Interdata 8/32 and involved the following tasks: (1) data base design, (2) data base generation, (3) data base load, and (4) develop and implement programs to simulate MFTF usage of the data base

The Drill Down Benchmark

NARCIS (Netherlands)

P.A. Boncz (Peter); T. Rühl (Tim); F. Kwakkel

1998-01-01

textabstractData Mining places specific requirements on DBMS query performance that cannot be evaluated satisfactorily using existing OLAP benchmarks. The DD Benchmark - defined here - provides a practical case and yardstick to explore how well a DBMS is able to support Data Mining applications. It

Development of parallel benchmark code by sheet metal forming simulator 'ITAS'

International Nuclear Information System (INIS)

Watanabe, Hiroshi; Suzuki, Shintaro; Minami, Kazuo

1999-03-01

This report describes the development of parallel benchmark code by sheet metal forming simulator 'ITAS'. ITAS is a nonlinear elasto-plastic analysis program by the finite element method for the purpose of the simulation of sheet metal forming. ITAS adopts the dynamic analysis method that computes displacement of sheet metal at every time unit and utilizes the implicit method with the direct linear equation solver. Therefore the simulator is very robust. However, it requires a lot of computational time and memory capacity. In the development of the parallel benchmark code, we designed the code by MPI programming to reduce the computational time. In numerical experiments on the five kinds of parallel super computers at CCSE JAERI, i.e., SP2, SR2201, SX-4, T94 and VPP300, good performances are observed. The result will be shown to the public through WWW so that the benchmark results may become a guideline of research and development of the parallel program. (author)

Benchmarking and Learning in Public Healthcare

DEFF Research Database (Denmark)

Buckmaster, Natalie; Mouritsen, Jan

2017-01-01

This research investigates the effects of learning-oriented benchmarking in public healthcare settings. Benchmarking is a widely adopted yet little explored accounting practice that is part of the paradigm of New Public Management. Extant studies are directed towards mandated coercive benchmarking...

Attila calculations for the 3-D C5G7 benchmark extension

International Nuclear Information System (INIS)

Wareing, T.A.; McGhee, J.M.; Barnett, D.A.; Failla, G.A.

2005-01-01

The performance of the Attila radiation transport software was evaluated for the 3-D C5G7 MOX benchmark extension, a follow-on study to the MOX benchmark developed by the 'OECD/NEA Expert Group on 3-D Radiation Transport Benchmarks'. These benchmarks were designed to test the ability of modern deterministic transport methods to model reactor problems without spatial homogenization. Attila is a general purpose radiation transport software package with an integrated graphical user interface (GUI) for analysis, set-up and postprocessing. Attila provides solutions to the discrete-ordinates form of the linear Boltzmann transport equation on a fully unstructured, tetrahedral mesh using linear discontinuous finite-element spatial differencing in conjunction with diffusion synthetic acceleration of inner iterations. The results obtained indicate that Attila can accurately solve the benchmark problem without spatial homogenization. (authors)

Work management practices that reduce dose and improve efficiency

International Nuclear Information System (INIS)

Miller, D.W.; Hulin, M.

1998-01-01

Work management practices at nuclear power plants can dramatically affect the outcome of annual site dose goals and outage costs. This presentation discusses global work management practices that contribute to dose reduction including work philosophy, work selection, work planning, work scheduling, worker training, work implementation and worker feedback. The presentation is based on a two-year international effort (sponsored by NEA/IAEA ISOE) to study effective work practices that reduce dose. Experts in this area believe that effective work selection and planning practices can substantially reduce occupational dose during refueling outages. For example, some plants represented in the expert group complete refueling outages in 12-18 days (Finland) with doses below 0,90 person-Sv. Other plants typically have 50-75 day outages with substantially higher site doses. The fundamental reasons for longer outages and higher occupational doses are examined. Good work management principles that have a proven track record of reducing occupational dose are summarized. Practical methods to reduce work duration and dose are explained. For example, scheduling at nuclear power plants can be improved by not only sequencing jobs on a time line but also including zone and resource-based considerations to avoid zone congestion and manpower delays. An ongoing, global, benchmarking effort is described which provides current duration and dose information for repetitive jobs to participating utilities world-wide. (author)

The Medical Library Association Benchmarking Network: development and implementation*

Science.gov (United States)

Dudden, Rosalind Farnam; Corcoran, Kate; Kaplan, Janice; Magouirk, Jeff; Rand, Debra C.; Smith, Bernie Todd

2006-01-01

Objective: This article explores the development and implementation of the Medical Library Association (MLA) Benchmarking Network from the initial idea and test survey, to the implementation of a national survey in 2002, to the establishment of a continuing program in 2004. Started as a program for hospital libraries, it has expanded to include other nonacademic health sciences libraries. Methods: The activities and timelines of MLA's Benchmarking Network task forces and editorial board from 1998 to 2004 are described. Results: The Benchmarking Network task forces successfully developed an extensive questionnaire with parameters of size and measures of library activity and published a report of the data collected by September 2002. The data were available to all MLA members in the form of aggregate tables. Utilization of Web-based technologies proved feasible for data intake and interactive display. A companion article analyzes and presents some of the data. MLA has continued to develop the Benchmarking Network with the completion of a second survey in 2004. Conclusions: The Benchmarking Network has provided many small libraries with comparative data to present to their administrators. It is a challenge for the future to convince all MLA members to participate in this valuable program. PMID:16636702

Method for simulating dose reduction in digital mammography using the Anscombe transformation

Energy Technology Data Exchange (ETDEWEB)

Borges, Lucas R., E-mail: lucas.rodrigues.borges@usp.br; Oliveira, Helder C. R. de; Nunes, Polyana F.; Vieira, Marcelo A. C. [Department of Electrical and Computer Engineering, São Carlos School of Engineering, University of São Paulo, 400 Trabalhador São-Carlense Avenue, São Carlos 13566-590 (Brazil); Bakic, Predrag R.; Maidment, Andrew D. A. [Department of Radiology, Hospital of the University of Pennsylvania, University of Pennsylvania, 3400 Spruce Street, Philadelphia, Pennsylvania 19104 (United States)

2016-06-15

Purpose: This work proposes an accurate method for simulating dose reduction in digital mammography starting from a clinical image acquired with a standard dose. Methods: The method developed in this work consists of scaling a mammogram acquired at the standard radiation dose and adding signal-dependent noise. The algorithm accounts for specific issues relevant in digital mammography images, such as anisotropic noise, spatial variations in pixel gain, and the effect of dose reduction on the detective quantum efficiency. The scaling process takes into account the linearity of the system and the offset of the detector elements. The inserted noise is obtained by acquiring images of a flat-field phantom at the standard radiation dose and at the simulated dose. Using the Anscombe transformation, a relationship is created between the calculated noise mask and the scaled image, resulting in a clinical mammogram with the same noise and gray level characteristics as an image acquired at the lower-radiation dose. Results: The performance of the proposed algorithm was validated using real images acquired with an anthropomorphic breast phantom at four different doses, with five exposures for each dose and 256 nonoverlapping ROIs extracted from each image and with uniform images. The authors simulated lower-dose images and compared these with the real images. The authors evaluated the similarity between the normalized noise power spectrum (NNPS) and power spectrum (PS) of simulated images and real images acquired with the same dose. The maximum relative error was less than 2.5% for every ROI. The added noise was also evaluated by measuring the local variance in the real and simulated images. The relative average error for the local variance was smaller than 1%. Conclusions: A new method is proposed for simulating dose reduction in clinical mammograms. In this method, the dependency between image noise and image signal is addressed using a novel application of the Anscombe

Method for simulating dose reduction in digital mammography using the Anscombe transformation

International Nuclear Information System (INIS)

Borges, Lucas R.; Oliveira, Helder C. R. de; Nunes, Polyana F.; Vieira, Marcelo A. C.; Bakic, Predrag R.; Maidment, Andrew D. A.

2016-01-01

Purpose: This work proposes an accurate method for simulating dose reduction in digital mammography starting from a clinical image acquired with a standard dose. Methods: The method developed in this work consists of scaling a mammogram acquired at the standard radiation dose and adding signal-dependent noise. The algorithm accounts for specific issues relevant in digital mammography images, such as anisotropic noise, spatial variations in pixel gain, and the effect of dose reduction on the detective quantum efficiency. The scaling process takes into account the linearity of the system and the offset of the detector elements. The inserted noise is obtained by acquiring images of a flat-field phantom at the standard radiation dose and at the simulated dose. Using the Anscombe transformation, a relationship is created between the calculated noise mask and the scaled image, resulting in a clinical mammogram with the same noise and gray level characteristics as an image acquired at the lower-radiation dose. Results: The performance of the proposed algorithm was validated using real images acquired with an anthropomorphic breast phantom at four different doses, with five exposures for each dose and 256 nonoverlapping ROIs extracted from each image and with uniform images. The authors simulated lower-dose images and compared these with the real images. The authors evaluated the similarity between the normalized noise power spectrum (NNPS) and power spectrum (PS) of simulated images and real images acquired with the same dose. The maximum relative error was less than 2.5% for every ROI. The added noise was also evaluated by measuring the local variance in the real and simulated images. The relative average error for the local variance was smaller than 1%. Conclusions: A new method is proposed for simulating dose reduction in clinical mammograms. In this method, the dependency between image noise and image signal is addressed using a novel application of the Anscombe

A Field-Based Aquatic Life Benchmark for Conductivity in ...

Science.gov (United States)

This report adapts the standard U.S. EPA methodology for deriving ambient water quality criteria. Rather than use toxicity test results, the adaptation uses field data to determine the loss of 5% of genera from streams. The method is applied to derive effect benchmarks for dissolved salts as measured by conductivity in Central Appalachian streams using data from West Virginia and Kentucky. This report provides scientific evidence for a conductivity benchmark in a specific region rather than for the entire United States.

Benchmarking & European Sustainable Transport Policies

DEFF Research Database (Denmark)

Gudmundsson, H.

2003-01-01

, Benchmarking is one of the management tools that have recently been introduced in the transport sector. It is rapidly being applied to a wide range of transport operations, services and policies. This paper is a contribution to the discussion of the role of benchmarking in the future efforts to...... contribution to the discussions within the Eusponsored BEST Thematic Network (Benchmarking European Sustainable Transport) which ran from 2000 to 2003....

Benchmarking – A tool for judgment or improvement?

DEFF Research Database (Denmark)

Rasmussen, Grane Mikael Gregaard

2010-01-01

perceptions of benchmarking will be presented; public benchmarking and best practice benchmarking. These two types of benchmarking are used to characterize and discuss the Danish benchmarking system and to enhance which effects, possibilities and challenges that follow in the wake of using this kind......Change in construction is high on the agenda for the Danish government and a comprehensive effort is done in improving quality and efficiency. This has led to an initiated governmental effort in bringing benchmarking into the Danish construction sector. This paper is an appraisal of benchmarking...... as it is presently carried out in the Danish construction sector. Many different perceptions of benchmarking and the nature of the construction sector, lead to an uncertainty in how to perceive and use benchmarking, hence, generating an uncertainty in understanding the effects of benchmarking. This paper addresses...

Storage-Intensive Supercomputing Benchmark Study

Energy Technology Data Exchange (ETDEWEB)

Cohen, J; Dossa, D; Gokhale, M; Hysom, D; May, J; Pearce, R; Yoo, A

2007-10-30

Critical data science applications requiring frequent access to storage perform poorly on today's computing architectures. This project addresses efficient computation of data-intensive problems in national security and basic science by exploring, advancing, and applying a new form of computing called storage-intensive supercomputing (SISC). Our goal is to enable applications that simply cannot run on current systems, and, for a broad range of data-intensive problems, to deliver an order of magnitude improvement in price/performance over today's data-intensive architectures. This technical report documents much of the work done under LDRD 07-ERD-063 Storage Intensive Supercomputing during the period 05/07-09/07. The following chapters describe: (1) a new file I/O monitoring tool iotrace developed to capture the dynamic I/O profiles of Linux processes; (2) an out-of-core graph benchmark for level-set expansion of scale-free graphs; (3) an entity extraction benchmark consisting of a pipeline of eight components; and (4) an image resampling benchmark drawn from the SWarp program in the LSST data processing pipeline. The performance of the graph and entity extraction benchmarks was measured in three different scenarios: data sets residing on the NFS file server and accessed over the network; data sets stored on local disk; and data sets stored on the Fusion I/O parallel NAND Flash array. The image resampling benchmark compared performance of software-only to GPU-accelerated. In addition to the work reported here, an additional text processing application was developed that used an FPGA to accelerate n-gram profiling for language classification. The n-gram application will be presented at SC07 at the High Performance Reconfigurable Computing Technologies and Applications Workshop. The graph and entity extraction benchmarks were run on a Supermicro server housing the NAND Flash 40GB parallel disk array, the Fusion-io. The Fusion system specs are as follows

BONFIRE: benchmarking computers and computer networks

OpenAIRE

Bouckaert, Stefan; Vanhie-Van Gerwen, Jono; Moerman, Ingrid; Phillips, Stephen; Wilander, Jerker

2011-01-01

The benchmarking concept is not new in the field of computing or computer networking. With “benchmarking tools”, one usually refers to a program or set of programs, used to evaluate the performance of a solution under certain reference conditions, relative to the performance of another solution. Since the 1970s, benchmarking techniques have been used to measure the performance of computers and computer networks. Benchmarking of applications and virtual machines in an Infrastructure-as-a-Servi...

Gamma irradiator dose mapping simulation using the MCNP code and benchmarking with dosimetry

International Nuclear Information System (INIS)

Sohrabpour, M.; Hassanzadeh, M.; Shahriari, M.; Sharifzadeh, M.

2002-01-01

The Monte Carlo transport code, MCNP, has been applied in simulating dose rate distribution in the IR-136 gamma irradiator system. Isodose curves, cumulative dose values, and system design data such as throughputs, over-dose-ratios, and efficiencies have been simulated as functions of product density. Simulated isodose curves, and cumulative dose values were compared with dosimetry values obtained using polymethyle-methacrylate, Fricke, ethanol-chlorobenzene, and potassium dichromate dosimeters. The produced system design data were also found to agree quite favorably with those of the system manufacturer's data. MCNP has thus been found to be an effective transport code for handling of various dose mapping excercises for gamma irradiators

Numisheet2005 Benchmark Analysis on Forming of an Automotive Underbody Cross Member: Benchmark 2

International Nuclear Information System (INIS)

Buranathiti, Thaweepat; Cao Jian

2005-01-01

This report presents an international cooperation benchmark effort focusing on simulations of a sheet metal stamping process. A forming process of an automotive underbody cross member using steel and aluminum blanks is used as a benchmark. Simulation predictions from each submission are analyzed via comparison with the experimental results. A brief summary of various models submitted for this benchmark study is discussed. Prediction accuracy of each parameter of interest is discussed through the evaluation of cumulative errors from each submission

SKaMPI: A Comprehensive Benchmark for Public Benchmarking of MPI

Directory of Open Access Journals (Sweden)

Ralf Reussner

2002-01-01

Full Text Available The main objective of the MPI communication library is to enable portable parallel programming with high performance within the message-passing paradigm. Since the MPI standard has no associated performance model, and makes no performance guarantees, comprehensive, detailed and accurate performance figures for different hardware platforms and MPI implementations are important for the application programmer, both for understanding and possibly improving the behavior of a given program on a given platform, as well as for assuring a degree of predictable behavior when switching to another hardware platform and/or MPI implementation. We term this latter goal performance portability, and address the problem of attaining performance portability by benchmarking. We describe the SKaMPI benchmark which covers a large fraction of MPI, and incorporates well-accepted mechanisms for ensuring accuracy and reliability. SKaMPI is distinguished among other MPI benchmarks by an effort to maintain a public performance database with performance data from different hardware platforms and MPI implementations.

Developing Benchmarking Criteria for CO2 Emissions

Energy Technology Data Exchange (ETDEWEB)

Neelis, M.; Worrell, E.; Mueller, N.; Angelini, T. [Ecofys, Utrecht (Netherlands); Cremer, C.; Schleich, J.; Eichhammer, W. [The Fraunhofer Institute for Systems and Innovation research, Karlsruhe (Germany)

2009-02-15

A European Union (EU) wide greenhouse gas (GHG) allowance trading scheme (EU ETS) was implemented in the EU in 2005. In the first two trading periods of the scheme (running up to 2012), free allocation based on historical emissions was the main methodology for allocation of allowances to existing installations. For the third trading period (2013 - 2020), the European Commission proposed in January 2008 a more important role of auctioning of allowances rather then free allocation. (Transitional) free allocation of allowances to industrial sectors will be determined via harmonized allocation rules, where feasible based on benchmarking. In general terms, a benchmark based method allocates allowances based on a certain amount of emissions per unit of productive output (i.e. the benchmark). This study aims to derive criteria for an allocation methodology for the EU Emission Trading Scheme based on benchmarking for the period 2013 - 2020. To test the feasibility of the criteria, we apply them to four example product groups: iron and steel, pulp and paper, lime and glass. The basis for this study is the Commission proposal for a revised ETS directive put forward on 23 January 2008 and does not take into account any changes to this proposal in the co-decision procedure that resulted in the adoption of the Energy and Climate change package in December 2008.

Methods of determining the effective dose in dental radiology

International Nuclear Information System (INIS)

Thilander-Klang, A.; Helmrot, E.

2010-01-01

A wide variety of X-ray equipment is used today in dental radiology, including intra-oral, ortho-pan-tomographic, cephalo-metric, cone-beam computed tomography (CBCT) and computed tomography (CT). This raises the question of how the radiation risks resulting from different kinds of examinations should be compared. The risk to the patient is usually expressed in terms of effective dose. However, it is difficult to determine its reliability, and it is difficult to make comparisons, especially when different modalities are used. The classification of the new CBCT units is also problematic as they are sometimes classified as CT units. This will lead to problems in choosing the best dosimetric method, especially when the examination geometry resembles more on an ordinary ortho-pan-tomographic examination, as the axis of rotation is not at the centre of the patient, and small radiation field sizes are used. The purpose of this study was to present different methods for the estimation of the effective dose from the equipment currently used in dental radiology, and to discuss their limitations. The methods are compared based on commonly used measurable and computable dose quantities, and their reliability in the estimation of the effective dose. (authors)

Robust EM Continual Reassessment Method in Oncology Dose Finding

Science.gov (United States)

Yuan, Ying; Yin, Guosheng

2012-01-01

The continual reassessment method (CRM) is a commonly used dose-finding design for phase I clinical trials. Practical applications of this method have been restricted by two limitations: (1) the requirement that the toxicity outcome needs to be observed shortly after the initiation of the treatment; and (2) the potential sensitivity to the prespecified toxicity probability at each dose. To overcome these limitations, we naturally treat the unobserved toxicity outcomes as missing data, and use the expectation-maximization (EM) algorithm to estimate the dose toxicity probabilities based on the incomplete data to direct dose assignment. To enhance the robustness of the design, we propose prespecifying multiple sets of toxicity probabilities, each set corresponding to an individual CRM model. We carry out these multiple CRMs in parallel, across which model selection and model averaging procedures are used to make more robust inference. We evaluate the operating characteristics of the proposed robust EM-CRM designs through simulation studies and show that the proposed methods satisfactorily resolve both limitations of the CRM. Besides improving the MTD selection percentage, the new designs dramatically shorten the duration of the trial, and are robust to the prespecification of the toxicity probabilities. PMID:22375092

Benchmark results in radiative transfer

International Nuclear Information System (INIS)

Garcia, R.D.M.; Siewert, C.E.

1986-02-01

Several aspects of the F N method are reported, and the method is used to solve accurately some benchmark problems in radiative transfer in the field of atmospheric physics. The method was modified to solve cases of pure scattering and an improved process was developed for computing the radiation intensity. An algorithms for computing several quantities used in the F N method was done. An improved scheme to evaluate certain integrals relevant to the method is done, and a two-term recursion relation that has proved useful for the numerical evaluation of matrix elements, basic for the method, is given. The methods used to solve the encountered linear algebric equations are discussed, and the numerical results are evaluated. (M.C.K.) [pt

Intercomparison of the finite difference and nodal discrete ordinates and surface flux transport methods for a LWR pool-reactor benchmark problem in X-Y geometry

International Nuclear Information System (INIS)

O'Dell, R.D.; Stepanek, J.; Wagner, M.R.

1983-01-01

The aim of the present work is to compare and discuss the three of the most advanced two dimensional transport methods, the finite difference and nodal discrete ordinates and surface flux method, incorporated into the transport codes TWODANT, TWOTRAN-NODAL, MULTIMEDIUM and SURCU. For intercomparison the eigenvalue and the neutron flux distribution are calculated using these codes in the LWR pool reactor benchmark problem. Additionally the results are compared with some results obtained by French collision probability transport codes MARSYAS and TRIDENT. Because the transport solution of this benchmark problem is close to its diffusion solution some results obtained by the finite element diffusion code FINELM and the finite difference diffusion code DIFF-2D are included

Patient-specific IMRT verification using independent fluence-based dose calculation software: experimental benchmarking and initial clinical experience

International Nuclear Information System (INIS)

Georg, Dietmar; Stock, Markus; Kroupa, Bernhard; Olofsson, Joergen; Nyholm, Tufve; Ahnesjoe, Anders; Karlsson, Mikael

2007-01-01

Experimental methods are commonly used for patient-specific intensity-modulated radiotherapy (IMRT) verification. The purpose of this study was to investigate the accuracy and performance of independent dose calculation software (denoted as 'MUV' (monitor unit verification)) for patient-specific quality assurance (QA). 52 patients receiving step-and-shoot IMRT were considered. IMRT plans were recalculated by the treatment planning systems (TPS) in a dedicated QA phantom, in which an experimental 1D and 2D verification (0.3 cm 3 ionization chamber; films) was performed. Additionally, an independent dose calculation was performed. The fluence-based algorithm of MUV accounts for collimator transmission, rounded leaf ends, tongue-and-groove effect, backscatter to the monitor chamber and scatter from the flattening filter. The dose calculation utilizes a pencil beam model based on a beam quality index. DICOM RT files from patient plans, exported from the TPS, were directly used as patient-specific input data in MUV. For composite IMRT plans, average deviations in the high dose region between ionization chamber measurements and point dose calculations performed with the TPS and MUV were 1.6 ± 1.2% and 0.5 ± 1.1% (1 S.D.). The dose deviations between MUV and TPS slightly depended on the distance from the isocentre position. For individual intensity-modulated beams (total 367), an average deviation of 1.1 ± 2.9% was determined between calculations performed with the TPS and with MUV, with maximum deviations up to 14%. However, absolute dose deviations were mostly less than 3 cGy. Based on the current results, we aim to apply a confidence limit of 3% (with respect to the prescribed dose) or 6 cGy for routine IMRT verification. For off-axis points at distances larger than 5 cm and for low dose regions, we consider 5% dose deviation or 10 cGy acceptable. The time needed for an independent calculation compares very favourably with the net time for an experimental approach

Power reactor pressure vessel benchmarks

International Nuclear Information System (INIS)

Rahn, F.J.

1978-01-01

A review is given of the current status of experimental and calculational benchmarks for use in understanding the radiation embrittlement effects in the pressure vessels of operating light water power reactors. The requirements of such benchmarks for application to pressure vessel dosimetry are stated. Recent developments in active and passive neutron detectors sensitive in the ranges of importance to embrittlement studies are summarized and recommendations for improvements in the benchmark are made. (author)

Benchmarking urban energy efficiency in the UK

International Nuclear Information System (INIS)

Keirstead, James

2013-01-01

This study asks what is the ‘best’ way to measure urban energy efficiency. There has been recent interest in identifying efficient cities so that best practices can be shared, a process known as benchmarking. Previous studies have used relatively simple metrics that provide limited insight on the complexity of urban energy efficiency and arguably fail to provide a ‘fair’ measure of urban performance. Using a data set of 198 urban UK local administrative units, three methods are compared: ratio measures, regression residuals, and data envelopment analysis. The results show that each method has its own strengths and weaknesses regarding the ease of interpretation, ability to identify outliers and provide consistent rankings. Efficient areas are diverse but are notably found in low income areas of large conurbations such as London, whereas industrial areas are consistently ranked as inefficient. The results highlight the shortcomings of the underlying production-based energy accounts. Ideally urban energy efficiency benchmarks would be built on consumption-based accounts, but interim recommendations are made regarding the use of efficiency measures that improve upon current practice and facilitate wider conversations about what it means for a specific city to be energy-efficient within an interconnected economy. - Highlights: • Benchmarking is a potentially valuable method for improving urban energy performance. • Three different measures of urban energy efficiency are presented for UK cities. • Most efficient areas are diverse but include low-income areas of large conurbations. • Least efficient areas perform industrial activities of national importance. • Improve current practice with grouped per capita metrics or regression residuals

Benchmarking and testing the “Sea Level Equation”

DEFF Research Database (Denmark)

Spada, G.; Barletta, Valentina Roberta; Klemann, V.

2012-01-01

through which the methods may be validated. Following the example of the mantle con-vection community and our recent successful Benchmark for Post Glacial Rebound codes (Spada et al., 2011), here we present the results of a benchmark study of independently developed codes de-signed to solve the SLE....... This study has taken place within a collaboration facilitated through the Eu-ropean Cooperation in Science and Technology (COST) Action ES0701. The tests involve predictions of past and current sea level variations, and 3D deformations of the Earth surface. In spite of the significant differences...

Electricity consumption in school buildings - benchmark and web tools; Elforbrug i skoler - benchmark og webvaerktoej

Energy Technology Data Exchange (ETDEWEB)

NONE

2006-07-01

The aim of this project has been to produce benchmarks for electricity consumption in Danish schools in order to encourage electricity conservation. An internet programme has been developed with the aim of facilitating schools' access to benchmarks and to evaluate energy consumption. The overall purpose is to create increased attention to the electricity consumption of each separate school by publishing benchmarks which take the schools' age and number of pupils as well as after school activities into account. Benchmarks can be used to make green accounts and work as markers in e.g. energy conservation campaigns, energy management and for educational purposes. The internet tool can be found on www.energiguiden.dk. (BA)

Estimation of absorbed doses on the basis of cytogenetic methods

International Nuclear Information System (INIS)

Shevchenko, V.A.; Rubanovich, A.V.; Snigiryova, G.P.

1998-01-01

Long-term studies in the field of radiation cytogenetics have resulted in the discovery of relationship between induction of chromosome aberrations and the type of ionizing radiation, their intensity and dose. This has served as a basis of biological dosimetry as an area of application of the revealed relationship, and has been used in the practice to estimate absorbed doses in people exposed to emergency irradiation. The necessity of using the methods of biological dosimetry became most pressing in connection with the Chernobyl accident in 1986, as well as in connection with other radiation situations that occurred in nuclear industry of the former USSR. The materials presented in our works demonstrate the possibility of applying cytogenetic methods for assessing absorbed doses in populations of different regions exposed to radiation as a result of accidents at nuclear facilities (Chernobyl, the village Muslymovo on the Techa river, the Three Mile Island nuclear power station in the USA where an accident occurred in 1979). Fundamentally, new possibilities for retrospective dose assessment are provided by the FISH-method that permits the assessment of absorbed doses after several decades since the exposure occurred. In addition, the application of this method makes it possible to restore the dynamics of unstable chromosome aberrations (dicentrics and centric rings), which is important for further improvement of the method of biological dosimetry based on the analysis of unstable chromosome aberrations. The purpose of our presentation is a brief description of the cytogenetic methods used in biological dosimetry, consideration of statistical methods of data analysis and a description of concrete examples of their application. (J.P.N.)

Using chemical benchmarking to determine the persistence of chemicals in a Swedish lake.

Science.gov (United States)

Zou, Hongyan; Radke, Michael; Kierkegaard, Amelie; MacLeod, Matthew; McLachlan, Michael S

2015-02-03

It is challenging to measure the persistence of chemicals under field conditions. In this work, two approaches for measuring persistence in the field were compared: the chemical mass balance approach, and a novel chemical benchmarking approach. Ten pharmaceuticals, an X-ray contrast agent, and an artificial sweetener were studied in a Swedish lake. Acesulfame K was selected as a benchmark to quantify persistence using the chemical benchmarking approach. The 95% confidence intervals of the half-life for transformation in the lake system ranged from 780-5700 days for carbamazepine to benchmarking approach agreed well with those from the mass balance approach (1-21% difference), indicating that chemical benchmarking can be a valid and useful method to measure the persistence of chemicals under field conditions. Compared to the mass balance approach, the benchmarking approach partially or completely eliminates the need to quantify mass flow of chemicals, so it is particularly advantageous when the quantification of mass flow of chemicals is difficult. Furthermore, the benchmarking approach allows for ready comparison and ranking of the persistence of different chemicals.

Toxicological Benchmarks for Screening Potential Contaminants of Concern for Effects on Terrestrial Plants

Energy Technology Data Exchange (ETDEWEB)

Suter, G.W. II

1993-01-01

One of the initial stages in ecological risk assessment for hazardous waste sites is screening contaminants to determine which of them are worthy of further consideration as contaminants of potential concern. This process is termed contaminant screening. It is performed by comparing measured ambient concentrations of chemicals to benchmark concentrations. Currently, no standard benchmark concentrations exist for assessing contaminants in soil with respect to their toxicity to plants. This report presents a standard method for deriving benchmarks for this purpose (phytotoxicity benchmarks), a set of data concerning effects of chemicals in soil or soil solution on plants, and a set of phytotoxicity benchmarks for 38 chemicals potentially associated with United States Department of Energy (DOE) sites. In addition, background information on the phytotoxicity and occurrence of the chemicals in soils is presented, and literature describing the experiments from which data were drawn for benchmark derivation is reviewed. Chemicals that are found in soil at concentrations exceeding both the phytotoxicity benchmark and the background concentration for the soil type should be considered contaminants of potential concern.

TSD-DOSE : a radiological dose assessment model for treatment, storage, and disposal facilities

International Nuclear Information System (INIS)

Pfingston, M.

1998-01-01

In May 1991, the U.S. Department of Energy (DOE), Office of Waste Operations, issued a nationwide moratorium on shipping slightly radioactive mixed waste from DOE facilities to commercial treatment, storage, and disposal (TSD) facilities. Studies were subsequently conducted to evaluate the radiological impacts associated with DOE's prior shipments through DOE's authorized release process under DOE Order 5400.5. To support this endeavor, a radiological assessment computer code--TSD-DOSE (Version 1.1)--was developed and issued by DOE in 1997. The code was developed on the basis of detailed radiological assessments performed for eight commercial hazardous waste TSD facilities. It was designed to utilize waste-specific and site-specific data to estimate potential radiological doses to on-site workers and the off-site public from waste handling operations at a TSD facility. The code has since been released for use by DOE field offices and was recently used by DOE to evaluate the release of septic waste containing residual radioactive material to a TSD facility licensed under the Resource Conservation and Recovery Act. Revisions to the code were initiated in 1997 to incorporate comments received from users and to increase TSD-DOSE's capability, accuracy, and flexibility. These updates included incorporation of the method used to estimate external radiation doses from DOE's RESRAD model and expansion of the source term to include 85 radionuclides. In addition, a detailed verification and benchmarking analysis was performed

BENCHMARKING – BETWEEN TRADITIONAL & MODERN BUSINESS ENVIRONMENT

Directory of Open Access Journals (Sweden)

Mihaela Ungureanu

2011-09-01

Full Text Available The concept of benchmarking requires a continuous process of performance improvement of different organizations in order to obtain superiority towards those perceived as market leader’s competitors. This superiority can always be questioned, its relativity originating in the quick growing evolution of the economic environment. The approach supports innovation in relation with traditional methods and it is based on the will of those managers who want to determine limits and seek excellence. The end of the twentieth century is the period of broad expression of benchmarking in various areas and its transformation from a simple quantitative analysis tool, to a resource of information on performance and quality of goods and services.

HS06 Benchmark for an ARM Server

Science.gov (United States)

Kluth, Stefan

2014-06-01

We benchmarked an ARM cortex-A9 based server system with a four-core CPU running at 1.1 GHz. The system used Ubuntu 12.04 as operating system and the HEPSPEC 2006 (HS06) benchmarking suite was compiled natively with gcc-4.4 on the system. The benchmark was run for various settings of the relevant gcc compiler options. We did not find significant influence from the compiler options on the benchmark result. The final HS06 benchmark result is 10.4.

HS06 benchmark for an ARM server

International Nuclear Information System (INIS)

Kluth, Stefan

2014-01-01

We benchmarked an ARM cortex-A9 based server system with a four-core CPU running at 1.1 GHz. The system used Ubuntu 12.04 as operating system and the HEPSPEC 2006 (HS06) benchmarking suite was compiled natively with gcc-4.4 on the system. The benchmark was run for various settings of the relevant gcc compiler options. We did not find significant influence from the compiler options on the benchmark result. The final HS06 benchmark result is 10.4.

Proton dose distribution measurements using a MOSFET detector with a simple dose-weighted correction method for LET effects.

Science.gov (United States)

Kohno, Ryosuke; Hotta, Kenji; Matsuura, Taeko; Matsubara, Kana; Nishioka, Shie; Nishio, Teiji; Kawashima, Mitsuhiko; Ogino, Takashi

2011-04-04

We experimentally evaluated the proton beam dose reproducibility, sensitivity, angular dependence and depth-dose relationships for a new Metal Oxide Semiconductor Field Effect Transistor (MOSFET) detector. The detector was fabricated with a thinner oxide layer and was operated at high-bias voltages. In order to accurately measure dose distributions, we developed a practical method for correcting the MOSFET response to proton beams. The detector was tested by examining lateral dose profiles formed by protons passing through an L-shaped bolus. The dose reproducibility, angular dependence and depth-dose response were evaluated using a 190 MeV proton beam. Depth-output curves produced using the MOSFET detectors were compared with results obtained using an ionization chamber (IC). Since accurate measurements of proton dose distribution require correction for LET effects, we developed a simple dose-weighted correction method. The correction factors were determined as a function of proton penetration depth, or residual range. The residual proton range at each measurement point was calculated using the pencil beam algorithm. Lateral measurements in a phantom were obtained for pristine and SOBP beams. The reproducibility of the MOSFET detector was within 2%, and the angular dependence was less than 9%. The detector exhibited a good response at the Bragg peak (0.74 relative to the IC detector). For dose distributions resulting from protons passing through an L-shaped bolus, the corrected MOSFET dose agreed well with the IC results. Absolute proton dosimetry can be performed using MOSFET detectors to a precision of about 3% (1 sigma). A thinner oxide layer thickness improved the LET in proton dosimetry. By employing correction methods for LET dependence, it is possible to measure absolute proton dose using MOSFET detectors.

TH-A-19A-04: Latent Uncertainties and Performance of a GPU-Implemented Pre-Calculated Track Monte Carlo Method

International Nuclear Information System (INIS)

Renaud, M; Seuntjens, J; Roberge, D

2014-01-01

Purpose: Assessing the performance and uncertainty of a pre-calculated Monte Carlo (PMC) algorithm for proton and electron transport running on graphics processing units (GPU). While PMC methods have been described in the past, an explicit quantification of the latent uncertainty arising from recycling a limited number of tracks in the pre-generated track bank is missing from the literature. With a proper uncertainty analysis, an optimal pre-generated track bank size can be selected for a desired dose calculation uncertainty. Methods: Particle tracks were pre-generated for electrons and protons using EGSnrc and GEANT4, respectively. The PMC algorithm for track transport was implemented on the CUDA programming framework. GPU-PMC dose distributions were compared to benchmark dose distributions simulated using general-purpose MC codes in the same conditions. A latent uncertainty analysis was performed by comparing GPUPMC dose values to a “ground truth” benchmark while varying the track bank size and primary particle histories. Results: GPU-PMC dose distributions and benchmark doses were within 1% of each other in voxels with dose greater than 50% of Dmax. In proton calculations, a submillimeter distance-to-agreement error was observed at the Bragg Peak. Latent uncertainty followed a Poisson distribution with the number of tracks per energy (TPE) and a track bank of 20,000 TPE produced a latent uncertainty of approximately 1%. Efficiency analysis showed a 937× and 508× gain over a single processor core running DOSXYZnrc for 16 MeV electrons in water and bone, respectively. Conclusion: The GPU-PMC method can calculate dose distributions for electrons and protons to a statistical uncertainty below 1%. The track bank size necessary to achieve an optimal efficiency can be tuned based on the desired uncertainty. Coupled with a model to calculate dose contributions from uncharged particles, GPU-PMC is a candidate for inverse planning of modulated electron radiotherapy

Improvement of dose evaluation method for employees at severe accident

International Nuclear Information System (INIS)

Onda, Takashi; Yoshida, Yoshitaka; Kudo, Seiichi; Nishimura, Kazuya

2003-01-01

It is expected that the selection of access routes for employees who engage in emergency work at a severe accident in a nuclear power plant makes a difference in their radiation dose values. In order to examine how much difference arises in the dose by the selection of the access routes, in the case of a severe accident in a pressurized water reactor plant, we improved the method to obtain the dose for employees and expanded the analyzing system. By the expansion of the system and the improvement of the method, we have realized the followings: (1) in the whole plant area, the dose evaluation is possible, (2) the efficiency of calculation is increased by the reduction of the number of radiation sources, etc, and (3) the function is improved by introduction of the sky shine calculation into the highest floor, etc. The improved system clarifies the followings: (1) the doses change by selected access routes, and this system can give the difference in the doses quantitatively, and (2) in order to suppress the dose, it is effective to choose the most adequate access route for the employees. (author)

Benchmarking road safety performance by grouping local territories : a study in The Netherlands.

NARCIS (Netherlands)

Aarts, L.T. & Houwing, S.

2015-01-01

The method of benchmarking provides an opportunity to learn from better performing territories to improve the effectiveness and efficiency of activities in a particular field of interest. Such a field of interest could be road safety. Road safety benchmarking can include several indicators, ranging

Performance Targets and External Benchmarking

DEFF Research Database (Denmark)

Friis, Ivar; Hansen, Allan; Vámosi, Tamás S.

Research on relative performance measures, transfer pricing, beyond budgeting initiatives, target costing, piece rates systems and value based management has for decades underlined the importance of external benchmarking in performance management. Research conceptualises external benchmarking...... as a market mechanism that can be brought inside the firm to provide incentives for continuous improvement and the development of competitive advances. However, whereas extant research primarily has focused on the importance and effects of using external benchmarks, less attention has been directed towards...... the conditions upon which the market mechanism is performing within organizations. This paper aims to contribute to research by providing more insight to the conditions for the use of external benchmarking as an element in performance management in organizations. Our study explores a particular type of external...

Repeated dose titration versus age-based method in electroconvulsive therapy: a pilot study

NARCIS (Netherlands)

Aten, J.J.; Oudega, M.L.; van Exel, E.; Stek, M.L.; van Waarde, J.A.

2015-01-01

In electroconvulsive therapy (ECT), a dose titration method (DTM) was suggested to be more individualized and therefore more accurate than formula-based dosing methods. A repeated DTM (every sixth session and dose adjustment accordingly) was compared to an age-based method (ABM) regarding treatment

Benchmarking in Czech Higher Education

OpenAIRE

Plaček Michal; Ochrana František; Půček Milan

2015-01-01

The first part of this article surveys the current experience with the use of benchmarking at Czech universities specializing in economics and management. The results indicate that collaborative benchmarking is not used on this level today, but most actors show some interest in its introduction. The expression of the need for it and the importance of benchmarking as a very suitable performance-management tool in less developed countries are the impetus for the second part of our article. Base...

Correlation of In Vivo Versus In Vitro Benchmark Doses (BMDs) Derived From Micronucleus Test Data: A Proof of Concept Study.

Science.gov (United States)

Soeteman-Hernández, Lya G; Fellows, Mick D; Johnson, George E; Slob, Wout

2015-12-01

In this study, we explored the applicability of using in vitro micronucleus (MN) data from human lymphoblastoid TK6 cells to derive in vivo genotoxicity potency information. Nineteen chemicals covering a broad spectrum of genotoxic modes of action were tested in an in vitro MN test using TK6 cells using the same study protocol. Several of these chemicals were considered to need metabolic activation, and these were administered in the presence of S9. The Benchmark dose (BMD) approach was applied using the dose-response modeling program PROAST to estimate the genotoxic potency from the in vitro data. The resulting in vitro BMDs were compared with previously derived BMDs from in vivo MN and carcinogenicity studies. A proportional correlation was observed between the BMDs from the in vitro MN and the BMDs from the in vivo MN assays. Further, a clear correlation was found between the BMDs from in vitro MN and the associated BMDs for malignant tumors. Although these results are based on only 19 compounds, they show that genotoxicity potencies estimated from in vitro tests may result in useful information regarding in vivo genotoxic potency, as well as expected cancer potency. Extension of the number of compounds and further investigation of metabolic activation (S9) and of other toxicokinetic factors would be needed to validate our initial conclusions. However, this initial work suggests that this approach could be used for in vitro to in vivo extrapolations which would support the reduction of animals used in research (3Rs: replacement, reduction, and refinement). © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology.

Benchmark simulation models, quo vadis?

Science.gov (United States)

Jeppsson, U; Alex, J; Batstone, D J; Benedetti, L; Comas, J; Copp, J B; Corominas, L; Flores-Alsina, X; Gernaey, K V; Nopens, I; Pons, M-N; Rodríguez-Roda, I; Rosen, C; Steyer, J-P; Vanrolleghem, P A; Volcke, E I P; Vrecko, D

2013-01-01

As the work of the IWA Task Group on Benchmarking of Control Strategies for wastewater treatment plants (WWTPs) is coming to an end, it is essential to disseminate the knowledge gained. For this reason, all authors of the IWA Scientific and Technical Report on benchmarking have come together to provide their insights, highlighting areas where knowledge may still be deficient and where new opportunities are emerging, and to propose potential avenues for future development and application of the general benchmarking framework and its associated tools. The paper focuses on the topics of temporal and spatial extension, process modifications within the WWTP, the realism of models, control strategy extensions and the potential for new evaluation tools within the existing benchmark system. We find that there are major opportunities for application within all of these areas, either from existing work already being done within the context of the benchmarking simulation models (BSMs) or applicable work in the wider literature. Of key importance is increasing capability, usability and transparency of the BSM package while avoiding unnecessary complexity.

Benchmark problems for radiological assessment codes. Final report

International Nuclear Information System (INIS)

Mills, M.; Vogt, D.; Mann, B.

1983-09-01

This report describes benchmark problems to test computer codes used in the radiological assessment of high-level waste repositories. The problems presented in this report will test two types of codes. The first type of code calculates the time-dependent heat generation and radionuclide inventory associated with a high-level waste package. Five problems have been specified for this code type. The second code type addressed in this report involves the calculation of radionuclide transport and dose-to-man. For these codes, a comprehensive problem and two subproblems have been designed to test the relevant capabilities of these codes for assessing a high-level waste repository setting

A Seafloor Benchmark for 3-dimensional Geodesy

Science.gov (United States)

Chadwell, C. D.; Webb, S. C.; Nooner, S. L.

2014-12-01

We have developed an inexpensive, permanent seafloor benchmark to increase the longevity of seafloor geodetic measurements. The benchmark provides a physical tie to the sea floor lasting for decades (perhaps longer) on which geodetic sensors can be repeatedly placed and removed with millimeter resolution. Global coordinates estimated with seafloor geodetic techniques will remain attached to the benchmark allowing for the interchange of sensors as they fail or become obsolete, or for the sensors to be removed and used elsewhere, all the while maintaining a coherent series of positions referenced to the benchmark. The benchmark has been designed to free fall from the sea surface with transponders attached. The transponder can be recalled via an acoustic command sent from the surface to release from the benchmark and freely float to the sea surface for recovery. The duration of the sensor attachment to the benchmark will last from a few days to a few years depending on the specific needs of the experiment. The recovered sensors are then available to be reused at other locations, or again at the same site in the future. Three pins on the sensor frame mate precisely and unambiguously with three grooves on the benchmark. To reoccupy a benchmark a Remotely Operated Vehicle (ROV) uses its manipulator arm to place the sensor pins into the benchmark grooves. In June 2014 we deployed four benchmarks offshore central Oregon. We used the ROV Jason to successfully demonstrate the removal and replacement of packages onto the benchmark. We will show the benchmark design and its operational capabilities. Presently models of megathrust slip within the Cascadia Subduction Zone (CSZ) are mostly constrained by the sub-aerial GPS vectors from the Plate Boundary Observatory, a part of Earthscope. More long-lived seafloor geodetic measures are needed to better understand the earthquake and tsunami risk associated with a large rupture of the thrust fault within the Cascadia subduction zone

Thermal and fast reactor benchmark testing of ENDF/B-6.4

International Nuclear Information System (INIS)

Liu Guisheng

1999-01-01

The benchmark testing for B-6.4 was done with the same benchmark experiments and calculating method as for B-6.2. The effective multiplication factors k eff , central reaction rate ratios of fast assemblies and lattice cell reaction rate ratios of thermal lattice cell assemblies were calculated and compared with testing results of B-6.2 and CENDL-2. It is obvious that 238 U data files are most important for the calculations of large fast reactors and lattice thermal reactors. However, 238 U data in the new version of ENDF/B-6 have not been renewed. Only data of 235 U, 27 Al, 14 N and 2 D have been renewed in ENDF/B-6.4. Therefor, it will be shown that the thermal reactor benchmark testing results are remarkably improved and the fast reactor benchmark testing results are not improved

The Concepts "Benchmarks and Benchmarking" Used in Education Planning: Teacher Education as Example

Science.gov (United States)

Steyn, H. J.

2015-01-01

Planning in education is a structured activity that includes several phases and steps that take into account several kinds of information (Steyn, Steyn, De Waal & Wolhuter, 2002: 146). One of the sets of information that are usually considered is the (so-called) "benchmarks" and "benchmarking" regarding the focus of a…

Automated benchmarking of peptide-MHC class I binding predictions

Science.gov (United States)

Trolle, Thomas; Metushi, Imir G.; Greenbaum, Jason A.; Kim, Yohan; Sidney, John; Lund, Ole; Sette, Alessandro; Peters, Bjoern; Nielsen, Morten

2015-01-01

Motivation: Numerous in silico methods predicting peptide binding to major histocompatibility complex (MHC) class I molecules have been developed over the last decades. However, the multitude of available prediction tools makes it non-trivial for the end-user to select which tool to use for a given task. To provide a solid basis on which to compare different prediction tools, we here describe a framework for the automated benchmarking of peptide-MHC class I binding prediction tools. The framework runs weekly benchmarks on data that are newly entered into the Immune Epitope Database (IEDB), giving the public access to frequent, up-to-date performance evaluations of all participating tools. To overcome potential selection bias in the data included in the IEDB, a strategy was implemented that suggests a set of peptides for which different prediction methods give divergent predictions as to their binding capability. Upon experimental binding validation, these peptides entered the benchmark study. Results: The benchmark has run for 15 weeks and includes evaluation of 44 datasets covering 17 MHC alleles and more than 4000 peptide-MHC binding measurements. Inspection of the results allows the end-user to make educated selections between participating tools. Of the four participating servers, NetMHCpan performed the best, followed by ANN, SMM and finally ARB. Availability and implementation: Up-to-date performance evaluations of each server can be found online at http://tools.iedb.org/auto_bench/mhci/weekly. All prediction tool developers are invited to participate in the benchmark. Sign-up instructions are available at http://tools.iedb.org/auto_bench/mhci/join. Contact: mniel@cbs.dtu.dk or bpeters@liai.org Supplementary information: Supplementary data are available at Bioinformatics online. PMID:25717196

Benchmarking and application of the state-of-the-art uncertainty analysis methods XSUSA and SHARK-X

International Nuclear Information System (INIS)

Aures, A.; Bostelmann, F.; Hursin, M.; Leray, O.

2017-01-01

Highlights: • Application of the uncertainty analysis methods XSUSA and SHARK-X. • Propagation of nuclear data uncertainty through PWR pin cell depletion calculation. • Uncertainty quantification of eigenvalue, nuclide densities and Doppler coefficient. • Top contributor to overall output uncertainty by sensitivity analysis. • Comparison with SAMPLER and TSUNAMI of the SCALE code package. - Abstract: This study presents collaborative work performed between GRS and PSI on benchmarking and application of the state-of-the-art uncertainty analysis methods XSUSA and SHARK-X. Applied to a PWR pin cell depletion calculation, both methods propagate input uncertainty from nuclear data to output uncertainty. The uncertainty of the multiplication factors, nuclide densities, and fuel temperature coefficients derived by both methods are compared at various burnup steps. Comparisons of these quantities are furthermore performed with the SAMPLER module of SCALE 6.2. The perturbation theory based TSUNAMI module of both SCALE 6.1 and SCALE 6.2 is additionally applied for comparisons of the reactivity coefficient.

Method for simulating dose reduction in digital mammography using the Anscombe transformation.

Science.gov (United States)

Borges, Lucas R; Oliveira, Helder C R de; Nunes, Polyana F; Bakic, Predrag R; Maidment, Andrew D A; Vieira, Marcelo A C

2016-06-01

This work proposes an accurate method for simulating dose reduction in digital mammography starting from a clinical image acquired with a standard dose. The method developed in this work consists of scaling a mammogram acquired at the standard radiation dose and adding signal-dependent noise. The algorithm accounts for specific issues relevant in digital mammography images, such as anisotropic noise, spatial variations in pixel gain, and the effect of dose reduction on the detective quantum efficiency. The scaling process takes into account the linearity of the system and the offset of the detector elements. The inserted noise is obtained by acquiring images of a flat-field phantom at the standard radiation dose and at the simulated dose. Using the Anscombe transformation, a relationship is created between the calculated noise mask and the scaled image, resulting in a clinical mammogram with the same noise and gray level characteristics as an image acquired at the lower-radiation dose. The performance of the proposed algorithm was validated using real images acquired with an anthropomorphic breast phantom at four different doses, with five exposures for each dose and 256 nonoverlapping ROIs extracted from each image and with uniform images. The authors simulated lower-dose images and compared these with the real images. The authors evaluated the similarity between the normalized noise power spectrum (NNPS) and power spectrum (PS) of simulated images and real images acquired with the same dose. The maximum relative error was less than 2.5% for every ROI. The added noise was also evaluated by measuring the local variance in the real and simulated images. The relative average error for the local variance was smaller than 1%. A new method is proposed for simulating dose reduction in clinical mammograms. In this method, the dependency between image noise and image signal is addressed using a novel application of the Anscombe transformation. NNPS, PS, and local noise

Aerodynamic Benchmarking of the Deepwind Design

DEFF Research Database (Denmark)

Bedona, Gabriele; Schmidt Paulsen, Uwe; Aagaard Madsen, Helge

2015-01-01

The aerodynamic benchmarking for the DeepWind rotor is conducted comparing different rotor geometries and solutions and keeping the comparison as fair as possible. The objective for the benchmarking is to find the most suitable configuration in order to maximize the power production and minimize...... the blade solicitation and the cost of energy. Different parameters are considered for the benchmarking study. The DeepWind blade is characterized by a shape similar to the Troposkien geometry but asymmetric between the top and bottom parts: this shape is considered as a fixed parameter in the benchmarking...

Piping benchmark problems for the ABB/CE System 80+ Standardized Plant

International Nuclear Information System (INIS)

Bezler, P.; DeGrassi, G.; Braverman, J.; Wang, Y.K.

1994-07-01

To satisfy the need for verification of the computer programs and modeling techniques that will be used to perform the final piping analyses for the ABB/Combustion Engineering System 80+ Standardized Plant, three benchmark problems were developed. The problems are representative piping systems subjected to representative dynamic loads with solutions developed using the methods being proposed for analysis for the System 80+ standard design. It will be required that the combined license licensees demonstrate that their solution to these problems are in agreement with the benchmark problem set. The first System 80+ piping benchmark is a uniform support motion response spectrum solution for one section of the feedwater piping subjected to safe shutdown seismic loads. The second System 80+ piping benchmark is a time history solution for the feedwater piping subjected to the transient loading induced by a water hammer. The third System 80+ piping benchmark is a time history solution of the pressurizer surge line subjected to the accelerations induced by a main steam line pipe break. The System 80+ reactor is an advanced PWR type

Can we reliably benchmark health technology assessment organizations?

Science.gov (United States)

Drummond, Michael; Neumann, Peter; Jönsson, Bengt; Luce, Bryan; Schwartz, J Sanford; Siebert, Uwe; Sullivan, Sean D

2012-04-01

In recent years, there has been growth in the use of health technology assessment (HTA) for making decisions about the reimbursement, coverage, or guidance on the use of health technologies. Given this greater emphasis on the use of HTA, it is important to develop standards of good practice and to benchmark the various HTA organizations against these standards. This study discusses the conceptual and methodological challenges associated with benchmarking HTA organizations and proposes a series of audit questions based on a previously published set of principles of good practice. It is concluded that a benchmarking exercise would be feasible and useful, although the question of who should do the benchmarking requires further discussion. Key issues for further research are the alternative methods for weighting the various principles and for generating an overall score, or summary statement of adherence to the principles. Any weighting system, if developed, would need to be explored in different jurisdictions to assess the extent to which the relative importance of the principles is perceived to vary. Finally, the development and precise wording of the audit questions requires further study, with a view to making the questions as unambiguous as possible, and the reproducibility of the assessments as high as possible.

Design study on dose evaluation method for employees at severe accident

Energy Technology Data Exchange (ETDEWEB)

Yoshida, Yoshitaka; Irie, Takashi; Kohriyama, Tamio [Institute of Nuclear Safety Systems Inc., Mihama, Fukui (Japan); Kudo, Seiichi [Mitsubishi Heavy Industries Ltd., Tokyo (Japan); Nishimura, Kazuya [Computer Software Development Co., Ltd., Tokyo (Japan)

2001-09-01

When we assume a severe accident in a nuclear power plant, it is required for rescue activity in the plant, accident management, repair work of failed parts and evaluation of employees to obtain radiation dose rate distribution or map in the plant and estimated dose value for the above works. However it might be difficult to obtain them accurately along the progress of the accident, because radiation monitors are not always installed in the areas where the accident management is planned or the repair work is thought for safety-related equipments. In this work, we analyzed diffusion of radioactive materials in case of a severe accident in a pressurized water reactor plant, investigated a method to obtain radiation dose rate in the plant from estimated radioactive sources, made up a prototype analyzing system by modeling a specific part of components and buildings in the plant from this design study on dose evaluation method for employees at severe accident, and then evaluated its availability. As a result, we obtained the followings: (1) A new dose evaluation method was established to predict the radiation dose rate in any point in the plant during a severe accident scenario. (2) This evaluation of total dose including moving route and time for the accident management and the repair work is useful for estimating radiation dose limit for these actions of the employees. (3) The radiation dose rate map is effective for identifying high radiation areas and for choosing a route with lower radiation dose rate. (author)

Design study on dose evaluation method for employees at severe accident

International Nuclear Information System (INIS)

Yoshida, Yoshitaka; Irie, Takashi; Kohriyama, Tamio; Kudo, Seiichi; Nishimura, Kazuya

2001-01-01

When we assume a severe accident in a nuclear power plant, it is required for rescue activity in the plant, accident management, repair work of failed parts and evaluation of employees to obtain radiation dose rate distribution or map in the plant and estimated dose value for the above works. However it might be difficult to obtain them accurately along the progress of the accident, because radiation monitors are not always installed in the areas where the accident management is planned or the repair work is thought for safety-related equipments. In this work, we analyzed diffusion of radioactive materials in case of a severe accident in a pressurized water reactor plant, investigated a method to obtain radiation dose rate in the plant from estimated radioactive sources, made up a prototype analyzing system by modeling a specific part of components and buildings in the plant from this design study on dose evaluation method for employees at severe accident, and then evaluated its availability. As a result, we obtained the followings: (1) A new dose evaluation method was established to predict the radiation dose rate in any point in the plant during a severe accident scenario. (2) This evaluation of total dose including moving route and time for the accident management and the repair work is useful for estimating radiation dose limit for these actions of the employees. (3) The radiation dose rate map is effective for identifying high radiation areas and for choosing a route with lower radiation dose rate. (author)

Manual method for dose calculation in gynecologic brachytherapy; Metodo manual para o calculo de doses em braquiterapia ginecologica

Energy Technology Data Exchange (ETDEWEB)

Vianello, Elizabeth A.; Almeida, Carlos E. de [Instituto Nacional do Cancer, Rio de Janeiro, RJ (Brazil); Biaggio, Maria F. de [Universidade do Estado, Rio de Janeiro, RJ (Brazil)

1998-09-01

This paper describes a manual method for dose calculation in brachytherapy of gynecological tumors, which allows the calculation of the doses at any plane or point of clinical interest. This method uses basic principles of vectorial algebra and the simulating orthogonal films taken from the patient with the applicators and dummy sources in place. The results obtained with method were compared with the values calculated with the values calculated with the treatment planning system model Theraplan and the agreement was better than 5% in most cases. The critical points associated with the final accuracy of the proposed method is related to the quality of the image and the appropriate selection of the magnification factors. This method is strongly recommended to the radiation oncology centers where are no treatment planning systems available and the dose calculations are manually done. (author) 10 refs., 5 figs.

Analysis of a multigroup stylized CANDU half-core benchmark

International Nuclear Information System (INIS)

Pounders, Justin M.; Rahnema, Farzad; Serghiuta, Dumitru

2011-01-01

Highlights: → This paper provides a benchmark that is a stylized model problem in more than two energy groups that is realistic with respect to the underlying physics. → An 8-group cross section library is provided to augment a previously published 2-group 3D stylized half-core CANDU benchmark problem. → Reference eigenvalues and selected pin and bundle fission rates are included. → 2-, 4- and 47-group Monte Carlo solutions are compared to analyze homogenization-free transport approximations that result from energy condensation. - Abstract: An 8-group cross section library is provided to augment a previously published 2-group 3D stylized half-core Canadian deuterium uranium (CANDU) reactor benchmark problem. Reference eigenvalues and selected pin and bundle fission rates are also included. This benchmark is intended to provide computational reactor physicists and methods developers with a stylized model problem in more than two energy groups that is realistic with respect to the underlying physics. In addition to transport theory code verification, the 8-group energy structure provides reactor physicist with an ideal problem for examining cross section homogenization and collapsing effects in a full-core environment. To this end, additional 2-, 4- and 47-group full-core Monte Carlo benchmark solutions are compared to analyze homogenization-free transport approximations incurred as a result of energy group condensation.

Benchmarking for On-Scalp MEG Sensors.

Science.gov (United States)

Xie, Minshu; Schneiderman, Justin F; Chukharkin, Maxim L; Kalabukhov, Alexei; Riaz, Bushra; Lundqvist, Daniel; Whitmarsh, Stephen; Hamalainen, Matti; Jousmaki, Veikko; Oostenveld, Robert; Winkler, Dag

2017-06-01

We present a benchmarking protocol for quantitatively comparing emerging on-scalp magnetoencephalography (MEG) sensor technologies to their counterparts in state-of-the-art MEG systems. As a means of validation, we compare a high-critical-temperature superconducting quantum interference device (high T c SQUID) with the low- T c SQUIDs of an Elekta Neuromag TRIUX system in MEG recordings of auditory and somatosensory evoked fields (SEFs) on one human subject. We measure the expected signal gain for the auditory-evoked fields (deeper sources) and notice some unfamiliar features in the on-scalp sensor-based recordings of SEFs (shallower sources). The experimental results serve as a proof of principle for the benchmarking protocol. This approach is straightforward, general to various on-scalp MEG sensors, and convenient to use on human subjects. The unexpected features in the SEFs suggest on-scalp MEG sensors may reveal information about neuromagnetic sources that is otherwise difficult to extract from state-of-the-art MEG recordings. As the first systematically established on-scalp MEG benchmarking protocol, magnetic sensor developers can employ this method to prove the utility of their technology in MEG recordings. Further exploration of the SEFs with on-scalp MEG sensors may reveal unique information about their sources.

Dynamic benchmarking of simulation codes

International Nuclear Information System (INIS)

Henry, R.E.; Paik, C.Y.; Hauser, G.M.

1996-01-01

Computer simulation of nuclear power plant response can be a full-scope control room simulator, an engineering simulator to represent the general behavior of the plant under normal and abnormal conditions, or the modeling of the plant response to conditions that would eventually lead to core damage. In any of these, the underlying foundation for their use in analysing situations, training of vendor/utility personnel, etc. is how well they represent what has been known from industrial experience, large integral experiments and separate effects tests. Typically, simulation codes are benchmarked with some of these; the level of agreement necessary being dependent upon the ultimate use of the simulation tool. However, these analytical models are computer codes, and as a result, the capabilities are continually enhanced, errors are corrected, new situations are imposed on the code that are outside of the original design basis, etc. Consequently, there is a continual need to assure that the benchmarks with important transients are preserved as the computer code evolves. Retention of this benchmarking capability is essential to develop trust in the computer code. Given the evolving world of computer codes, how is this retention of benchmarking capabilities accomplished? For the MAAP4 codes this capability is accomplished through a 'dynamic benchmarking' feature embedded in the source code. In particular, a set of dynamic benchmarks are included in the source code and these are exercised every time the archive codes are upgraded and distributed to the MAAP users. Three different types of dynamic benchmarks are used: plant transients; large integral experiments; and separate effects tests. Each of these is performed in a different manner. The first is accomplished by developing a parameter file for the plant modeled and an input deck to describe the sequence; i.e. the entire MAAP4 code is exercised. The pertinent plant data is included in the source code and the computer

Benchmarking HIV health care

DEFF Research Database (Denmark)

Podlekareva, Daria; Reekie, Joanne; Mocroft, Amanda

2012-01-01

ABSTRACT: BACKGROUND: State-of-the-art care involving the utilisation of multiple health care interventions is the basis for an optimal long-term clinical prognosis for HIV-patients. We evaluated health care for HIV-patients based on four key indicators. METHODS: Four indicators of health care we...... document pronounced regional differences in adherence to guidelines and can help to identify gaps and direct target interventions. It may serve as a tool for assessment and benchmarking the clinical management of HIV-patients in any setting worldwide....

Medical school benchmarking - from tools to programmes.

Science.gov (United States)

Wilkinson, Tim J; Hudson, Judith N; Mccoll, Geoffrey J; Hu, Wendy C Y; Jolly, Brian C; Schuwirth, Lambert W T

2015-02-01

Benchmarking among medical schools is essential, but may result in unwanted effects. To apply a conceptual framework to selected benchmarking activities of medical schools. We present an analogy between the effects of assessment on student learning and the effects of benchmarking on medical school educational activities. A framework by which benchmarking can be evaluated was developed and applied to key current benchmarking activities in Australia and New Zealand. The analogy generated a conceptual framework that tested five questions to be considered in relation to benchmarking: what is the purpose? what are the attributes of value? what are the best tools to assess the attributes of value? what happens to the results? and, what is the likely "institutional impact" of the results? If the activities were compared against a blueprint of desirable medical graduate outcomes, notable omissions would emerge. Medical schools should benchmark their performance on a range of educational activities to ensure quality improvement and to assure stakeholders that standards are being met. Although benchmarking potentially has positive benefits, it could also result in perverse incentives with unforeseen and detrimental effects on learning if it is undertaken using only a few selected assessment tools.

Computerized simulation methods for dose reduction, in radiodiagnosis

International Nuclear Information System (INIS)

Brochi, M.A.C.

1990-01-01

The present work presents computational methods that allow the simulation of any situation encountered in diagnostic radiology. Parameters of radiographic techniques that yield a standard radiographic image, previously chosen, and so could compare the dose of radiation absorbed by the patient is studied. Initially the method was tested on a simple system composed of 5.0 cm of water and 1.0 mm of aluminium and, after verifying experimentally its validity, it was applied in breast and arm fracture radiographs. It was observed that the choice of the filter material is not an important factor, because analogous behaviours were presented by aluminum, iron, copper, gadolinium, and other filters. A method of comparison of materials based on the spectral match is shown. Both the results given by this simulation method and the experimental measurements indicate an equivalence of brass and copper, both more efficient than aluminium, in terms of exposition time, but not of dose. (author)

Design study on dose evaluation method for employees at severe accident

International Nuclear Information System (INIS)

Yoshida, Yoshitaka; Irie, Takashi; Kohriyama, Tamio; Kudo, Seiichi; Nishimura, Kazuya

2002-01-01

If a severe accident occurs in a pressurized water reactor plant, it is required to estimate dose values of operators engaged in emergency such as accident management, repair of failed parts. However, it might be difficult to measure radiation dose rate during the progress of an accident, because radiation monitors are not always installed in areas where the emergency activities are required. In this study, we analyzed the transport of radioactive materials in case of a severe accident, investigated a method to obtain radiation dose rate in the plant from estimated radioactive sources, made up a prototype analyzing system from this design study, and then evaluated its availability. As a result, we obtained the following: (1) A new dose evaluation method was established to predict the radiation dose rate at any point in the plant during a severe accident scenario. (2) This evaluation of total dose including access route and time for emergency activities is useful for estimating radiation dose limit for these employee actions. (3) The radiation dose rate map is effective for identifying high radiation areas and for choosing a route with lower radiation dose rate. (author)

Shielding Benchmark Computational Analysis

International Nuclear Information System (INIS)

Hunter, H.T.; Slater, C.O.; Holland, L.B.; Tracz, G.; Marshall, W.J.; Parsons, J.L.

2000-01-01

Over the past several decades, nuclear science has relied on experimental research to verify and validate information about shielding nuclear radiation for a variety of applications. These benchmarks are compared with results from computer code models and are useful for the development of more accurate cross-section libraries, computer code development of radiation transport modeling, and building accurate tests for miniature shielding mockups of new nuclear facilities. When documenting measurements, one must describe many parts of the experimental results to allow a complete computational analysis. Both old and new benchmark experiments, by any definition, must provide a sound basis for modeling more complex geometries required for quality assurance and cost savings in nuclear project development. Benchmarks may involve one or many materials and thicknesses, types of sources, and measurement techniques. In this paper the benchmark experiments of varying complexity are chosen to study the transport properties of some popular materials and thicknesses. These were analyzed using three-dimensional (3-D) models and continuous energy libraries of MCNP4B2, a Monte Carlo code developed at Los Alamos National Laboratory, New Mexico. A shielding benchmark library provided the experimental data and allowed a wide range of choices for source, geometry, and measurement data. The experimental data had often been used in previous analyses by reputable groups such as the Cross Section Evaluation Working Group (CSEWG) and the Organization for Economic Cooperation and Development/Nuclear Energy Agency Nuclear Science Committee (OECD/NEANSC)

Issues in Benchmark Metric Selection

Science.gov (United States)

Crolotte, Alain

It is true that a metric can influence a benchmark but will esoteric metrics create more problems than they will solve? We answer this question affirmatively by examining the case of the TPC-D metric which used the much debated geometric mean for the single-stream test. We will show how a simple choice influenced the benchmark and its conduct and, to some extent, DBMS development. After examining other alternatives our conclusion is that the “real” measure for a decision-support benchmark is the arithmetic mean.

Benchmarking clinical photography services in the NHS.

Science.gov (United States)

Arbon, Giles

2015-01-01

Benchmarking is used in services across the National Health Service (NHS) using various benchmarking programs. Clinical photography services do not have a program in place and services have to rely on ad hoc surveys of other services. A trial benchmarking exercise was undertaken with 13 services in NHS Trusts. This highlights valuable data and comparisons that can be used to benchmark and improve services throughout the profession.

Benchmark density functional theory calculations for nanoscale conductance

DEFF Research Database (Denmark)

Strange, Mikkel; Bækgaard, Iben Sig Buur; Thygesen, Kristian Sommer

2008-01-01

We present a set of benchmark calculations for the Kohn-Sham elastic transmission function of five representative single-molecule junctions. The transmission functions are calculated using two different density functional theory methods, namely an ultrasoft pseudopotential plane-wave code...

Benchmarking Danish Industries

DEFF Research Database (Denmark)

Gammelgaard, Britta; Bentzen, Eric; Aagaard Andreassen, Mette

2003-01-01

compatible survey. The International Manufacturing Strategy Survey (IMSS) doesbring up the question of supply chain management, but unfortunately, we did not have access to thedatabase. Data from the members of the SCOR-model, in the form of benchmarked performance data,may exist, but are nonetheless...... not public. The survey is a cooperative project "Benchmarking DanishIndustries" with CIP/Aalborg University, the Danish Technological University, the DanishTechnological Institute and Copenhagen Business School as consortia partners. The project has beenfunded by the Danish Agency for Trade and Industry...

Use of Monte Carlo computation in benchmarking radiotherapy treatment planning system algorithms

International Nuclear Information System (INIS)

Lewis, R.D.; Ryde, S.J.S.; Seaby, A.W.; Hancock, D.A.; Evans, C.J.

2000-01-01

Radiotherapy treatments are becoming more complex, often requiring the dose to be calculated in three dimensions and sometimes involving the application of non-coplanar beams. The ability of treatment planning systems to accurately calculate dose under a range of these and other irradiation conditions requires evaluation. Practical assessment of such arrangements can be problematical, especially when a heterogeneous medium is used. This work describes the use of Monte Carlo computation as a benchmarking tool to assess the dose distribution of external photon beam plans obtained in a simple heterogeneous phantom by several commercially available 3D and 2D treatment planning system algorithms. For comparison, practical measurements were undertaken using film dosimetry. The dose distributions were calculated for a variety of irradiation conditions designed to show the effects of surface obliquity, inhomogeneities and missing tissue above tangential beams. The results show maximum dose differences of 47% between some planning algorithms and film at a point 1 mm below a tangentially irradiated surface. Overall, the dose distribution obtained from film was most faithfully reproduced by the Monte Carlo N-Particle results illustrating the potential of Monte Carlo computation in evaluating treatment planning system algorithms. (author)

Method for pulse to pulse dose reproducibility applied to electron linear accelerators

International Nuclear Information System (INIS)

Ighigeanu, D.; Martin, D.; Oproiu, C.; Cirstea, E.; Craciun, G.

2002-01-01

An original method for obtaining programmed beam single shots and pulse trains with programmed pulse number, pulse repetition frequency, pulse duration and pulse dose is presented. It is particularly useful for automatic control of absorbed dose rate level, irradiation process control as well as in pulse radiolysis studies, single pulse dose measurement or for research experiments where pulse-to-pulse dose reproducibility is required. This method is applied to the electron linear accelerators, ALIN-10 of 6.23 MeV and 82 W and ALID-7, of 5.5 MeV and 670 W, built in NILPRP. In order to implement this method, the accelerator triggering system (ATS) consists of two branches: the gun branch and the magnetron branch. ATS, which synchronizes all the system units, delivers trigger pulses at a programmed repetition rate (up to 250 pulses/s) to the gun (80 kV, 10 A and 4 ms) and magnetron (45 kV, 100 A, and 4 ms).The accelerated electron beam existence is determined by the electron gun and magnetron pulses overlapping. The method consists in controlling the overlapping of pulses in order to deliver the beam in the desired sequence. This control is implemented by a discrete pulse position modulation of gun and/or magnetron pulses. The instabilities of the gun and magnetron transient regimes are avoided by operating the accelerator with no accelerated beam for a certain time. At the operator 'beam start' command, the ATS controls electron gun and magnetron pulses overlapping and the linac beam is generated. The pulse-to-pulse absorbed dose variation is thus considerably reduced. Programmed absorbed dose, irradiation time, beam pulse number or other external events may interrupt the coincidence between the gun and magnetron pulses. Slow absorbed dose variation is compensated by the control of the pulse duration and repetition frequency. Two methods are reported in the electron linear accelerators' development for obtaining the pulse to pulse dose reproducibility: the method

Method for calculating individual equivalent doses and cumulative dose of population in the vicinity of nuclear power plant site

International Nuclear Information System (INIS)

Namestek, L.; Khorvat, D; Shvets, J.; Kunz, Eh.

1976-01-01

A method of calculating the doses of external and internal person irradiation in the nuclear power plant vicinity under conditions of normal operation and accident situations has been described. The main difference between the above method and methods used up to now is the use of a new antropomorphous representation of a human body model together with all the organs. The antropomorphous model of human body and its organs is determined as a set of simple solids, coordinates of disposistion of the solids, sizes, masses, densities and composition corresponding the genuine organs. The use of the Monte-Carlo method is the second difference. The results of the calculations according to the model suggested can be used for determination: a critical group of inhabitans under conditions of normal plant operation; groups of inhabitants most subjected to irradiation in the case of possible accident; a critical sector with a maximum collective dose in the case of an accident; a critical radioisotope favouring the greatest contribution to an individual equivalent dose; critical irradiation ways promoting a maximum contribution to individual equivalent doses; cumulative collective doses for the whole region or for a chosen part of the region permitting to estimate a population dose. The consequent method evoluation suggests the development of separate units of the calculationg program, critical application and the selection of input data of physical, plysiological and ecological character and improvement of the calculated program for the separate concrete events [ru

A phantom based method for deriving typical patient doses from measurements of dose-area product on populations of patients

International Nuclear Information System (INIS)

Chapple, C.-L.; Broadhead, D.A.

1995-01-01

One of the chief sources of uncertainty in the comparison of patient dosimetry data is the influence of patient size on dose. Dose has been shown to relate closely to the equivalent diameter of the patient. This concept has been used to derive a prospective, phantom based method for determining size correction factors for measurements of dose-area product. The derivation of the size correction factor has been demonstrated mathematically, and the appropriate factor determined for a number of different X-ray sets. The use of phantom measurements enables the effect of patient size to be isolated from other factors influencing patient dose. The derived factors agree well with those determined retrospectively from patient dose survey data. Size correction factors have been applied to the results of a large scale patient dose survey, and this approach has been compared with the method of selecting patients according to their weight. For large samples of data, mean dose-area product values are independent of the analysis method used. The chief advantage of using size correction factors is that it allows all patient data to be included in a survey, whereas patient selection has been shown to exclude approximately half of all patients. (author)

OECD/NEA Burnup Credit Calculational Criticality Benchmark Phase I-B Results

International Nuclear Information System (INIS)

DeHart, M.D.

1993-01-01

Burnup credit is an ongoing technical concern for many countries that operate commercial nuclear power reactors. In a multinational cooperative effort to resolve burnup credit issues, a Burnup Credit Working Group has been formed under the auspices of the Nuclear Energy Agency of the Organization for Economic Cooperation and Development. This working group has established a set of well-defined calculational benchmarks designed to study significant aspects of burnup credit computational methods. These benchmarks are intended to provide a means for the intercomparison of computer codes, methods, and data applied in spent fuel analysis. The benchmarks have been divided into multiple phases, each phase focusing on a particular feature of burnup credit analysis. This report summarizes the results and findings of the Phase I-B benchmark, which was proposed to provide a comparison of the ability of different code systems and data libraries to perform depletion analysis for the prediction of spent fuel isotopic concentrations. Results included here represent 21 different sets of calculations submitted by 16 different organizations worldwide, and are based on a limited set of nuclides determined to have the most important effect on the neutron multiplication factor of light-water-reactor spent fuel. A comparison of all sets of results demonstrates that most methods are in agreement to within 10% in the ability to estimate the spent fuel concentrations of most actinides. All methods are within 11% agreement about the average for all fission products studied. Furthermore, most deviations are less than 10%, and many are less than 5%. The exceptions are 149 Sm, 151 Sm, and 155 Gd

Specification for the VERA Depletion Benchmark Suite

Energy Technology Data Exchange (ETDEWEB)

Kim, Kang Seog [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2015-12-17

CASL-X-2015-1014-000 iii Consortium for Advanced Simulation of LWRs EXECUTIVE SUMMARY The CASL neutronics simulator MPACT is under development for the neutronics and T-H coupled simulation for the pressurized water reactor. MPACT includes the ORIGEN-API and internal depletion module to perform depletion calculations based upon neutron-material reaction and radioactive decay. It is a challenge to validate the depletion capability because of the insufficient measured data. One of the detoured methods to validate it is to perform a code-to-code comparison for benchmark problems. In this study a depletion benchmark suite has been developed and a detailed guideline has been provided to obtain meaningful computational outcomes which can be used in the validation of the MPACT depletion capability.

Fitting and benchmarking of Monte Carlo output parameters for iridium-192 high dose rate brachytherapy source

International Nuclear Information System (INIS)

Acquah, F.G.

2011-01-01

Brachytherapy, the use of radioactive sources for the treatment of tumours is an important tool in radiation oncology. Accurate calculations of dose delivered to malignant and normal tissues are the main responsibility of the Medical Physics staff. With the use of Treatment Planning System (TPS) computers now becoming a standard practice in the Radiation Oncology Departments, Independent calculations to certify the results of these commercial TPSs are important part of a good quality management system for brachytherapy implants. There are inherent errors in the dose distributions produced by these TPSs due to its failure to account for heterogeneity in the calculation algorithms and Monte Carlo (MC) method seems to be the panacea for these corrections. In this study, a fit functional form using MC output parameters was performed to reduce dose calculation uncertainty using the Matlab software curve fitting applications. This includes the modification of the AAPM TG-43 parameters to accommodate the new developments for a rapid brachytherapy dose rate calculation. Analytical computations were performed to hybridize the anisotropy function, F(r,θ) and radial dose function, g(r) into a single new function f(r,θ) for the Nucletron microSelectron High Dose Rate 'new or v2' (mHDRv2) 192 Ir brachytherapy source. In order to minimize computation time and to improve the accuracy of manual calculations, the dosimetry function f(r,θ) used fewer parameters and formulas for the fit. Using MC outputs as the standard, the percentage errors for the fits were calculated and used to evaluate the average and maximum uncertainties. Dose rate deviation between the MC data and fit were also quantified as errors(E), which showed minimal values. These results showed that the dosimetry parameters from this study as compared to those of MC outputs parameters were in good agreement and better than the results obtained from literature. The work confirms a lot of promise in building robust

Benchmarking the Multidimensional Stellar Implicit Code MUSIC

Science.gov (United States)

Goffrey, T.; Pratt, J.; Viallet, M.; Baraffe, I.; Popov, M. V.; Walder, R.; Folini, D.; Geroux, C.; Constantino, T.

2017-04-01

We present the results of a numerical benchmark study for the MUltidimensional Stellar Implicit Code (MUSIC) based on widely applicable two- and three-dimensional compressible hydrodynamics problems relevant to stellar interiors. MUSIC is an implicit large eddy simulation code that uses implicit time integration, implemented as a Jacobian-free Newton Krylov method. A physics based preconditioning technique which can be adjusted to target varying physics is used to improve the performance of the solver. The problems used for this benchmark study include the Rayleigh-Taylor and Kelvin-Helmholtz instabilities, and the decay of the Taylor-Green vortex. Additionally we show a test of hydrostatic equilibrium, in a stellar environment which is dominated by radiative effects. In this setting the flexibility of the preconditioning technique is demonstrated. This work aims to bridge the gap between the hydrodynamic test problems typically used during development of numerical methods and the complex flows of stellar interiors. A series of multidimensional tests were performed and analysed. Each of these test cases was analysed with a simple, scalar diagnostic, with the aim of enabling direct code comparisons. As the tests performed do not have analytic solutions, we verify MUSIC by comparing it to established codes including ATHENA and the PENCIL code. MUSIC is able to both reproduce behaviour from established and widely-used codes as well as results expected from theoretical predictions. This benchmarking study concludes a series of papers describing the development of the MUSIC code and provides confidence in future applications.

Benchmarking of human resources management

Directory of Open Access Journals (Sweden)

David M. Akinnusi

2008-11-01

Full Text Available This paper reviews the role of human resource management (HRM which, today, plays a strategic partnership role in management. The focus of the paper is on HRM in the public sector, where much hope rests on HRM as a means of transforming the public service and achieving much needed service delivery. However, a critical evaluation of HRM practices in the public sector reveals that these services leave much to be desired. The paper suggests the adoption of benchmarking as a process to revamp HRM in the public sector so that it is able to deliver on its promises. It describes the nature and process of benchmarking and highlights the inherent difficulties in applying benchmarking in HRM. It concludes with some suggestions for a plan of action. The process of identifying “best” practices in HRM requires the best collaborative efforts of HRM practitioners and academicians. If used creatively, benchmarking has the potential to bring about radical and positive changes in HRM in the public sector. The adoption of the benchmarking process is, in itself, a litmus test of the extent to which HRM in the public sector has grown professionally.

Integrating Best Practice and Performance Indicators To Benchmark the Performance of a School System. Benchmarking Paper 940317.

Science.gov (United States)

Cuttance, Peter

This paper provides a synthesis of the literature on the role of benchmarking, with a focus on its use in the public sector. Benchmarking is discussed in the context of quality systems, of which it is an important component. The paper describes the basic types of benchmarking, pertinent research about its application in the public sector, the…

Benchmarking and Sustainable Transport Policy

DEFF Research Database (Denmark)

Gudmundsson, Henrik; Wyatt, Andrew; Gordon, Lucy

2004-01-01

Order to learn from the best. In 2000 the European Commission initiated research to explore benchmarking as a tool to promote policies for ‘sustainable transport’. This paper reports findings and recommendations on how to address this challenge. The findings suggest that benchmarking is a valuable...... tool that may indeed help to move forward the transport policy agenda. However, there are major conditions and limitations. First of all it is not always so straightforward to delimit, measure and compare transport services in order to establish a clear benchmark. Secondly ‘sustainable transport......’ evokes a broad range of concerns that are hard to address fully at the level of specific practices. Thirdly policies are not directly comparable across space and context. For these reasons attempting to benchmark ‘sustainable transport policies’ against one another would be a highly complex task, which...

Fully automated treatment planning for head and neck radiotherapy using a voxel-based dose prediction and dose mimicking method

Science.gov (United States)

McIntosh, Chris; Welch, Mattea; McNiven, Andrea; Jaffray, David A.; Purdie, Thomas G.

2017-08-01

Recent works in automated radiotherapy treatment planning have used machine learning based on historical treatment plans to infer the spatial dose distribution for a novel patient directly from the planning image. We present a probabilistic, atlas-based approach which predicts the dose for novel patients using a set of automatically selected most similar patients (atlases). The output is a spatial dose objective, which specifies the desired dose-per-voxel, and therefore replaces the need to specify and tune dose-volume objectives. Voxel-based dose mimicking optimization then converts the predicted dose distribution to a complete treatment plan with dose calculation using a collapsed cone convolution dose engine. In this study, we investigated automated planning for right-sided oropharaynx head and neck patients treated with IMRT and VMAT. We compare four versions of our dose prediction pipeline using a database of 54 training and 12 independent testing patients by evaluating 14 clinical dose evaluation criteria. Our preliminary results are promising and demonstrate that automated methods can generate comparable dose distributions to clinical. Overall, automated plans achieved an average of 0.6% higher dose for target coverage evaluation criteria, and 2.4% lower dose at the organs at risk criteria levels evaluated compared with clinical. There was no statistically significant difference detected in high-dose conformity between automated and clinical plans as measured by the conformation number. Automated plans achieved nine more unique criteria than clinical across the 12 patients tested and automated plans scored a significantly higher dose at the evaluation limit for two high-risk target coverage criteria and a significantly lower dose in one critical organ maximum dose. The novel dose prediction method with dose mimicking can generate complete treatment plans in 12-13 min without user interaction. It is a promising approach for fully automated treatment

MCR2S unstructured mesh capabilities for use in shutdown dose rate analysis

International Nuclear Information System (INIS)

Eade, T.; Stonell, D.; Turner, A.

2015-01-01

Highlights: • Advancements in shutdown dose rate calculations will be needed as fusion moves from experimental reactors to full scale demonstration reactors in order to ensure the safety of personnel. • The MCR2S shutdown dose rate tool has been modified to allow shutdown dose rates calculations using an unstructured mesh. • The unstructured mesh capability of MCR2S was used on three shutdown dose rate models, a simple sphere, the ITER computational benchmark and the DEMO computational benchmark. • The results showed a reasonable agreement between an unstructured mesh approach and the CSG approach and highlighted the need to carefully choose the unstructured mesh resolution. - Abstract: As nuclear fusion progresses towards a sustainable energy source and the power of tokamak devices increases, a greater understanding of the radiation fields will be required. As well as on-load radiation fields, off-load or shutdown radiation field are an important consideration for the safety and economic viability of a commercial fusion reactor. Previously codes such as MCR2S have been written in order to predict the shutdown dose rates within, and in regions surrounding, a fusion reactor. MCR2S utilises a constructive solid geometry (CSG) model and a superimposed structured mesh to calculate 3-D maps of the shutdown dose rate. A new approach to MCR2S calculations is proposed and implemented using a single unstructured mesh to replace both the CSG model and the superimposed structured mesh. This new MCR2S approach has been demonstrated on three models of increasing complexity. These models were: a sphere, the ITER computational shutdown dose rate benchmark and the DEMO computational shutdown dose rate benchmark. In each case the results were compared to MCR2S calculations performed using MCR2S with CSG geometry and a superimposed structured mesh. It was concluded that the results from the unstructured mesh implementation of MCR2S compared well to the CSG structured mesh