Kofoed, Kristian; Kiszka-Kanowitz, Marianne; Albrectsen, Jens Mørch; Andersen, Ove
A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV-associat......A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV...
... immediately if you notice any changes in your skin or any lumps or masses anywhere in your body.Some teenage and young adult males who took azathioprine alone or with another medication called a tumor necrosis factor (TNF) blocker to treat Crohn's disease (a ...
Boman Linnman, Pernilla
Syftet med mitt arbete har varit att undersöka hur en skola använder sig av klasstödjare och EQ i arbetet mot kränkande behandling. Den frågeställning som jag har utgått från är: Hur ser värdegrundsarbetet ut på en skola, med avseende på likabehandlingsteam, klasstödjare och EQ uppdrag? I min undersökning har jag tagit del av hur en skola arbetar med ett likabehandlingsteam och klasstödjare. Likabehandlingsteamet består av två lärare som tillsammans med klasstödjare, bestående av elever arbe...
Apelseth, Eva Fohlin; Amlie, Christine
Antisosial atferd blant barn og ungdom er et stort og økende helsemessig og økonomisk problem. Parent Management Training – Oregon (PMT-O), et behandlings- og forebyggingsprogram for familier med barn som fremviser antisosial adferd, blir for tiden implementert i Norge som ledd i satsingen på psykisk helsevern. PMT-O er basert på ”social learning interaction theory”, utviklet av Patterson og medarbeidere ved Oregon Social Learning Center. PMT-O er et detaljert program for styrking av foreldre...
Ekeroth, Helena; Yngström, Henrik
Denna studies syfte är att belysa hur professionella som i sitt yrke möter hjälpsökande spelberoende individer uppfattar och reflekterar kring möjligheten att arbeta med hjälp och behandling av spelberoende utifrån sin organisations förutsättningar och ansvar. Studien har genomförts genom djupintervjuer med professionella inom kommun, landsting, en privat ägd behandlingsorganisation och en nationell organisation inriktade mot spelberoende i syfte att erhålla en så bred bild av spektrumet som ...
Sørensen, Merete Juul; Thomsen, Per Hove
Depression hos børn og unge er relativt hyppigt forekommende og kan have svære konsekvenser. Den specifikke antidepressive behandling kan være psykoterapeutisk eller medikamentel. I artiklen gennemgås på baggrund af systematisk litteratursøgning den videnskabelige evidens for effekten af kognitiv...... adfærdsterapi hos børn og unge med depression....
Isidor, F.; Moore, R.
insurance system to support patients in need for more expensive treatments. Dansk: Hvilke subjektive erfaringer har danske tandlæger i privat praksis med at foreslå og få gennemført behandling med kroner og broer? Et postomdelt spørgeskema blev udfyldt og returneret af 216 privatpraktiserende tandlæger i en......English:What subjective experiences have Danish dentists in private practice to propose and implement treatment with crowns and bridges? A mailed questionnaire were completed and returned by 216 private practice dentists for a random sample from Aarhus. Of these, 22% thought that it was...... gennemsnit kun 36% der faktisk får denne behandling. Tandlægerne mente at begrundelsen herfor var at patienterne havde manglende økonomisk mulighed eller en anden økonomisk prioritering. Tandlæger der syntes at det var ubehageligt at foreslå kroner og broer, angav mere end fem gange hyppigere manglende...
Ridder, Hanne Mette Ochsner
At reflektere over sine følelser og sin egen situation, være kreativ og fantasifuld, og kunne planlægge og udføre målrettede handlinger hænger sammen med funktioner der involverer den forreste del af hjernen. Disse evner eller funktioner kan skades ved frontotemporale demensformer. Fra Rigshospit...
Denne artikel behandler spørgsmålet, om mentaliseringsbaseret terapi er en metode der medfører et skift i terapeutisk forholdemåde for analytisk orienterede musikterapeuter i arbejde med patienter med personlighedsforstyrrelse. Artiklen skal ses om en del af den teoretiske integrationer af MBT i...
Background: A significant number of women of childbearing age have bipolar disorder. Several of the drugs used in the treatment of bipolar disorder have been associated with an increased risk of congenital malformation. Objective: The purpose of this review is to examine the risk of major congenital malformations related to medications used in the treatment of pregnant women with bipolar disorder. Methods: A literature research, using MEDLINE/PubMed, EMBASE and Cochrane databases...
Endresen, Helge; Kaarigstad, Ole Marius
Denne oppgaven omhandler regnskapsmessige problemstillinger knyttet til mer- og mindreuttak av petroleum. Disse uttaksdifferansene oppstår både som følger av måten oppstrømsvirksomheten i mange tilfeller er organisert, og som følger av praktiske sider ved produksjonen av petroleum. Problemstillingene aktualiseres blant annet i og med publiseringen av ny inntektsstandard innenfor IFRS – IFRS 15. Dessuten er sitasjonen per i dag slik at den gjeldende inntektsstandarden, IAS 18, e...
Hansen, L. K.; Cecere, Stefano; Thøgersen, Thøger
A 41-year-old man developed severe interstitial lung disease (ILD) after treatment with infliximab (IFX) and azathioprine (AZA). A relapse of ulcerative colitis was treated with corticosteroids (CS) and IFX as rescue therapy. Following remission AZA was given as prophylaxis. AZA was initiated the...
Adelborg, Kasper; Ebbehøj, Eva; Nielsen, Jens Cosedis;
Amiodarone is an effective antiarrhythmic drug for supraventricular and ventricular arrhythmias. A majority of patients treated with amiodarone suffer from mild adverse events, however, serious life-threatening adverse events caused by amiodarone are also seen. This review describes the...... pharmacology, interactions, side and adverse effects of amiodarone and highlights the importance of a systematic interdisciplinary follow-up protocol for outpatients treated with amiodarone....
Roseva-Nielsen, Natasha G; Svendsen, Jesper Hastrup
About 20 years ago the first patient received an implantable cardioverter defibrillator (ICD), and since then the number of implants have increased dramatically. The ICD can terminate ventricular fibrillation and ventricular tachycardia. Studies of secondary prophylaxis show that ICD treatment can...
Sammendrag Tittel Oppgavens overordnede tittel er Afasi og flerspråklighet . Undertittelen beskriver problemstillingen Hvilke faktorer påvirker logopedisk behandling av personer med afasi og flerspråklig bakgrunn? En spørreundersøkelse fra Tyskland . Bakgrunn og formål Med tysk som morsmål og norsk som hverdagsspråk har jeg en personlig interesse for problemstillinger innen flerspråklighet. Å miste språkferdigheter som følge av en hjerneskade forandrer hverdagen til den ram...
Ellen B. Roll
Full Text Available Lysbehandling av nyfødte med gulsott har vært brukt i mer enn 30 år uten at metoden har blitt videreutvikleti noen særlig grad. Man regner med at mellom 5 og 10% av alle nyfødte blir lysbehandlet. Behandlingengjennomføres ved at barnet legges i synlig lys fra spesielle fototerapilamper i mange timer, opptilflere dager. Lysets bølgelengde og intensitet har stor betydning for effektiviteten av behandlingen, og enskal ikke se bort fra risikoen for bivirkninger. Resultater av behandlingen bør undersøkes grundigere, bådefor å vurdere hvor mye bilirubinmengden reduseres, og for å oppdage mulige bivirkninger. Med tanke påbivirkninger kan det ta mer enn 30 år før disse er manifestert. Oppfølgingsstudier som har blitt foretatt, kanha for små tidsrammer, og det kan være spørsmål om det er lyseffekter eller effekter av bilirubintoksisitetsom har blitt registrert. Målet med vårt kliniske og eksperimentelle arbeid på området er å foreta studiersom kan bidra til at behandlingen kan bli mer optimal, særlig med hensyn til lysets intensitet og bølgelengde.I vårt epidemiologiske arbeid ønsker vi å se på langtidseffekter av lysbehandling, spesielt kreftutvikling(lymfatisk leukemi og malignt melanom.Roll EB, Christensen T. Phototherapy of newborns with hyperbilirubinemia – need for better . Nor J Epidemiol 1997; 7 (1: 93-98. ENGLISH SUMMARYTreating jaundiced newborns with artificial light has been done for the last three decades without substantialimprovements of the method. It can be estimated that between 5 and 10% of all newborns receivephototherapy. The standard treatment is the use of artificial, visible light sources for many hours up toseveral days. The wavelength and intensity of the light are factors influencing the effect of the treatment,however, the risk for long-term side effects should be considered. The results of the treatment need morethorough investigation for two purposes; to evaluate the therapeutic
Magnussen, P; Gelletlie, R; Bygbjerg, Ib Christian
the patients had varying degrees of liver involvement which were reversible. Neutropenia did not occur. Various parameters for assessing the therapeutic effect are mentioned. Albendazol appears to be effective in the treatment of non-operable hydatid disease and to prevent recurrence after surgery....
Schnack, Christina; Hansen, Carina Ørts; Beck-Nielsen, Henning;
The efficacy and safety of endoscopic ultrasound (EUS)-guided alcohol ablation of an insulinoma in a patient not candidate for surgery is being evaluated. A 89 year-old male patient with insulinoma and serious cardiac disease was treated with EUS-guided alcohol ablation. The only complication was a...... slight degree of pancreatitis. Two months after the ablation values of plasma glucose and serum pro-insulin were normalized. EUS-guided alcohol ablation is a safe and efficient alternative to surgical resection of insulinomas in poor surgical candidates....
Mindfulness i klinisk behandling är ingen enhetlig företeelse. Ett flertal sätt att definiera, operationalisera och tillämpa mindfulness samexisterar i det kliniska rummet. Syftet med denna studie var att åskådliggöra terapeuters kvalitativt varierande sätt att beskriva, använda och uppleva mindfulness i klinisk behandling och att undersöka faktorer av betydelse för dessa variationer. Elva terapeuters arbete studerades genom semistrukturerade intervjuer varpå en teoristyrd tematisk analys av ...
Holmström, Annika; Mårtensson, Lotta
BAKGRUND Modifierad Atkins Diet (MAD) och ketogenkost är kostbehandlingar som ordineras till barn med svårbehandlad epilepsi. Andra patientgrupper som behandlas med dessa dieter är patienter med glukostransportprotein typ 1-brist. Kostbehandlingarna är kolhydratfattiga och fettrika. I Sverige finns fyra sjukhus som arbetar med MAD och ketogenkost. I dagsläget saknas studier som beskriver hur behandlingarna upplevs av berörda familjer. SYFTE Syftet med studien var att utforska hur föräldrar ti...
Elmeland, Karen; Hecksher, Dorte
Hvordan kan det være, at nogle mennesker kan komme ud af deres afhængighed uden at få behandling? Hvordan adskiller de sig fra dem, der søger behandling? Det er noget af det, der forskes i på Center for Rusmiddelforskning....
Jarbøl, Dorte Ejg; Kjeldsen, H.C.; Schaffalitzky de Muckadell, Ove B.
almen praksis er empirisk behandling med antisekretorisk medicin, med efterfølgende endoskopi for nonrespondere. Noninvasiv test for Helico-bacter pylori (Hp) efterfulgt af eradikationskur til Hp-positive (Hp- test-and-treat ) er en strategi, der anbefales i flere guidelines til yngre patienter......Dyspepsi er et heterogent symptomkompleks, der dækker over smerte og ubehag i den øvre del af abdomen. Selv om området er genstand for stor opmærksomhed, er der ikke konsensus om den optimale udrednings- og behandlingsstrategi. Den mest anvendte strategi i behandlingen af ikkeundersøgt dyspepsi i...
Madsen, Lars Henrik Gam
Bogen redegør for risici forbundet med at gøre misligholdelse gældende, når den anden part modregner. I den forbindelse behandles den såkaldte standpunktsrisiko, dvs. risikoen ved at indtage et forkert standpunkt. Det belyses, hvordan de almindelige principper om modregning kan begrænse kreditors...
Krogh, Kenneth; Thomsen, Peter
På Kvægbrugets Forsøgscenter blev de rutinemæssige klovbade i maj 2007 erstattet med månedlige tjek af klove i beskærerboks og behandling af klovlidelser, herunder især Digital Dermatitis. Behandlingseffekten har været høj med 90 % helbredte efter en måned. Udgivelsesdato: april 2008......På Kvægbrugets Forsøgscenter blev de rutinemæssige klovbade i maj 2007 erstattet med månedlige tjek af klove i beskærerboks og behandling af klovlidelser, herunder især Digital Dermatitis. Behandlingseffekten har været høj med 90 % helbredte efter en måned. Udgivelsesdato: april 2008...
Laust, Jakob; Lau, Marianne Engelbrecht; Waaddegaard, Mette
konsekvenser. BED blev i 2013 optaget i DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) som en selvstændig diagnose og BED forventes medtaget i den forestående revision af det internationale diagnose system, ICD-11. Sundhedsstyrelsen gav på denne baggrund satspuljemidler til erfaringsopsamling......Titel: Afrapportering vedr. SATS-puljemidler til behandling og erfaringsopsamling vedr. BED for perioden 1. marts 2013 – 1. maj 2015. Baggrund: Binge Eating Disorder (BED), på dansk tvangsoverspisning, er en udbredt, men overset spiseforstyrrelse med alvorlige psykiske, fysiske og sociale...
Thomsen, Per Hove; Sørensen, Merete Juul
Depression hos børn og unge er relativt hyppigt forekommende og kan have svære konsekvenser. Den specifikke antidepressive behandling kan være psykoterapeutisk eller medikamentel. I artiklen gennemgås på baggrund af systematisk litteratursøgning den videnskabelige evidens for medikamentel...... behandling af depression hos børn og unge med hovedvægten lagt på de mest veldokumenterede medikamenter: selektive serotoningenoptagelseshæmmere....
Viju Moses; Banumathi Ramakrishna; Kurien Thomas
We report a case of cholestatic hepatitis developed one week after exposure to azathioprine. The subsequent prolonged cholestatic phase was followed by full clinical remission. Current knowledge on pathogenesis and epidemiology and the diagnostic challenges presented by this rare complication are discussed, followed by recommendations for monitoring and management.
Full Text Available We report a case of cholestatic hepatitis developed one week after exposure to azathioprine. The subsequent prolonged cholestatic phase was followed by full clinical remission. Current knowledge on pathogenesis and epidemiology and the diagnostic challenges presented by this rare complication are discussed, followed by recommendations for monitoring and management.
Larsen, Claus Morten; Mandrup-Poulsen, Thomas
Biologic therapeutics are currently not approved for the treatment of patients with type 1 and type 2 diabetes. However, promising results from recent randomized controlled studies suggest that biologic therapeutics have therapeutic potential. This article summarizes the causal steps of the...... pathogenesis of type 1 and type 2 diabetes which are targeted by biologic therapeutics and reviews the treatment results. Udgivelsesdato: 2008-Jun-9...
Rasmussen, K; Heitmann, M; Nielsen, J I;
The use of ACE-inhibitors has increased greatly during the last years. They were first used in treating hypertension, but nowadays cardiac diseases, mainly cardiac failure, are common indications. This means that the drugs are used in the treatment of more elderly patients who often have generali......The use of ACE-inhibitors has increased greatly during the last years. They were first used in treating hypertension, but nowadays cardiac diseases, mainly cardiac failure, are common indications. This means that the drugs are used in the treatment of more elderly patients who often have...... generalised atherosclerosis. This means that the patients must be controlled more often after initiation of treatment, especially concerning kidney function, since treatment with ACE-inhibitors can cause pronounced changes in renal haemodynamics and kidney function. This review focuses on the effects of ACE-inhibitors...... on renal haemodynamics and kidney function, which may be positive, with preservation of kidney function in diabetic and other chronic nephropathy, or negative, for example in cases with atherosclerotic stenosis of large or small renal arteries. It is concluded, that in cases of diabetic nephropathy an ACE-inhibitor...
Mejrup, Kristian; Bjerring-Nielsen, Mattias
Abstract: This article has a twofold purpose: to investigate the symbolic richness and abundant sweetness of honey and to employ ‘honey treatment’ as a strategy for reading the honeycombapocalypse comprised in the Jewish legend of Joseph and Aseneth. This text tells of Aseneth’s encounter with a...... entirely perturbed and paralysed. In fact, her free speech and wits remain as if protected by a honeysweetened agency. The article emphasizes the necessity of a ‘conversion’ by the reader enabling him to grasp the sublime potential of the aesthetics of sweetness....
Penninga, Ida Elisabeth Irene; Larsen, H.K.; Andersen, S.E.
Methotrexate (MTX) is used in the treatment of malignant and non-malignant diseases. This case report describes impotence as a seldom but possible overlooked adverse effect to MTX treatment. A 58 year-old man was treated for erythrodermia with a weekly dose of 7.5 mg MTX. He developed erective...
Thyssen, Jacob Pontoppidan; Christensen, Lise H; Zachariae, Claus O C
An increasing number of patients undergo soft-tissue augmentation. The quality depends on the applied filler substance, the compliance of the patient and the physician. Long-term adverse reactions are referred to as nodules or granulomas. Nodules following degradable gels and polyacrylamide...
Sørensen, Anne Louise; Larsen, Herdis
We here report a case of idiopathic hypereosinophilic syndrome with prompt response to treatment with imatinib. The patient presented with chest pain, myalgias, fatigue and weakness. Blood tests and bone marrow examination revealed striking eosinophilia. Clonal or reactive disorders were excluded...... by a wide range of diagnostic examinations. Treatment with high-dosis corticosteroids and hydroxyurea had little effect. Additional treatment with imatinib resulted in prompt symptomatic improvement and full haematological remission within five days of therapy. Udgivelsesdato: 2008-Jan-21...
Abstract Atopic dermatitis is a persistent, chronic, relapsing inflammatory skin disease, presenting most often in early childhood. It is strongly linked to hay fever, asthma an bronkitis. The cause of atopic dermatitis is unknown, though a genetic pre-dispotition and a combination of allergic and non-allergic factors appear to be important in determining disease expression. Conventional treatment consists of emollients and corticosteroids, dietary manipulation and habit reversal. The in...
Hovedparten af psykofarmaka har seksuelle bivirkninger. De seksuelle bivirkninger kan medføre en reduceret livskvalitet og være årsag til nonkomplians. For eksempel angives for antidepressiva, at 30-60 % af de behandlede patienter udvikler seksuel dysfunktion. Efterhånden er der dog udviklet enke...... af seksuel dysfunktion, fx sildenafil. Overordnet må det imidlertid konstateres, at der foreligger relativt få data inden for dette område, og især savnes der kontrollerede undersøgelser. Udgivelsesdato: 2002-Oct-7...
Stenstrøm, Anne Dorte; Sindø, Ingrid
Tourette's syndrome (TS) is a motoric disorder characterised by multiple motor and vocal tics. The treatment for patients with moderate to severe TS includes antipsychotic medication. A case report is described in which a 20 year-old male had taken antipsychotic medication since the age of five......, due to TS. The initial treatment consisted of pimozide and risperidone, both of which had an unsatisfactorily efficacy on tics and side effects in the form of weight gain and sedation. The patient is now treated with aripiprazole and there is a marked reduction of tics and no side effects...
Attarzadeh, Amir Pasha; Ryge, Camilla
We report a case of spontaneous non-traumatic bilateral rupture of the Achilles tendons following ciprofloxacin treatment. A 54-year-old man presented with spontaneous Achilles tendon rupture on the left side, tendinitis and partial tear on the right side following few days of treatment with...... ciprofloxacin 500 mg twice daily and long-term treatment with prednisolon 10 mg once daily. This rare side effect caused by concurrent treatment with steroids and ciprofloxacin should be kept in mind. Any signs of tendinitis following this treatment should arouse the physicians' suspicion towards ciprofloxacin....
Christensen, L.A.; Dahlerup, J.F.; Nielsen, M.J.;
BACKGROUND: Thiopurines are widely used to maintain remission in inflammatory bowel disease. Treatment during pregnancy is generally recommended to improve the chance of a normal birth outcome, but advice concerning breastfeeding is conflicting. Aim To estimate the exposure of breastfed infants to...... 6-mercaptopurine, as a metabolite of azathioprine, from maternal milk. METHODS: Eight lactating women with inflammatory bowel disease receiving maintenance therapy with azathioprine 75-200 mg daily were studied. Milk and plasma samples were obtained 30 and 60 min after drug administration and hourly...... maternal milk. After 6 h an average of 10% of the peak values were measured. CONCLUSIONS: The major part of 6-mercaptopurine in breast milk is excreted within the first 4 h after drug intake. On the basis of maximum concentration measured, the infant ingests mercaptopurine of <0.008 mg/kg bodyweight/24 h...
Keiding, Hans; Hildebrandt, Per; Burke, Thomas;
Formålet med denne analyse var set såvel fra samfundets som fra det danske sundhedsvæsens perspektiv at evaluere omkostningseffektiviteten af losartan sammenlignet med atenolol ved behandling af hypertension, baseret på Losartan Intervention For Endpoint (LIFE)-undersøgelsens data Udgivelsesdato...
Gong, Yanzhang; Christensen, E; Gluud, C
Azathioprine is used for patients with primary biliary cirrhosis, but the therapeutic responses in randomised clinical trials have been conflicting.......Azathioprine is used for patients with primary biliary cirrhosis, but the therapeutic responses in randomised clinical trials have been conflicting....
Jensen, Mette Kold; Vedsted-Hansen, Hanne; Hansen, Tia G. B.
Endometriose er en kronisk underlivssygdom med smerter og en række afledte problemer, som ikke nødvendigvis kan behandles med lægelige tiltag. Artiklen argumenterer for, at en mindfulness-baseret tilgang med fokus på smertehåndtering kan anvendes til denne klientgruppe. I vestlig terapeutisk samm...
Pedersen, Birgith; Bundgaard Sørensen, Lene; Stricker, Lisbeth;
Patienter, der får kemoterapi med højemetogene stoffer lider stadig af kvalme og opkastning trods understøttende behandling med moderne antieemtika som 5HT3-antagonister eksempelvis ondansetron. Akupunkturstimulation anvendes for flere lidelser i sundhedsvæsenet og det undersøges om der er evidens...
Pedersen, Birgith; Sørensen, Lene Bundgaard; Stricker, Lisbeth;
Patienter, der får kemoterapi med højemetogene stoffer lider stadig af kvalme og opkastning trods understøttende behandling med moderne antieemtika som 5HT3-antagonister eksempelvis ondansetron. Akupunkturstimulation anvendes for flere lidelser i sundhedsvæsenet og det undersøges om der er...
Davis, M.; Eddleston, A L; Williams, R.
A patient is described who suffered hypersenitivity reactions (anorexia, nausea and vomiting) as well as cholestatic jaundice from therapy with azathioprine. Evidence is given that the 2 reactions were mediated by different portions of the azathioprine molecule.
Full Text Available azathioprine AZP 00046 ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Human.../in_vitro/azathioprine.Human.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/i...n_vitro/azathioprine.Rat.in_vitro.Liver.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates/LATEST/Rat/in_vi...vo/Liver/Single/azathioprine.Rat.in_vivo.Liver.Single.zip ftp://ftp.biosciencedbc.jp/archive/open-tggates
Pentland, B; Adams, G G; Mawdsley, C
The results of azathioprine therapy in five patients with chronic progressive or relapsing idiopathic inflammatory polyneuropathy are described. In four patients a sustained improvement followed treatment and in the other patient azathioprine successfully replaced corticosteroid therapy. The improvement was often delayed for up to three months. The literature on the use of azathioprine in chronic polyneuropathy is reviewed. We suggest that there is a place for azathioprine treatment in patien...
Lunde, Anita; Johannessen, Helle
Baggrund: Interessen for komplementær og alternativ behandling (KAB) er stadig stigende, og der kan dokumenteres et større forbrug af KAB blandt kræftpatienter. Patienter anvender primært KAB som supplement til deres konventionelle behandling, og mange så gerne KAB som en integreret praksis. Fler...
Der sker i disse år meget indenfor både forskning og behandling i neurorehabilitering. Både grundforskning og kliniske studier bidrager til viden om neuroplasticitet og til udvikling og dokumentation af forskellige behandlingsformer og det er vigtigt at det ergoterapeutiske felt følger med. Denne...
Wasniowski, Benjamin; Melin, Carina
Introduktion: Akut hjärtinfarkt är en vanlig dödsorsak. Viktigaste behandlingsinsatsen vid hjärtinfarkt är att snabbt öppna det ockluderade kranskärlet genom primär Perkutan Coronar Intervention (PCI). Viktigt är även att behandlingen förhindrar att kärlet åter ockluderar. Detta görs genom att behandla med det blodproppshämmande och kärlpåverkande läkemedlet Clopidogrel. Enligt en ny behandlingsrutin ges Clopidogrel redan i ambulansen vid konstaterande av hjärtinfarkt för att uppnå effekt så ...
Møller, Jacob; Damgaard, Anders; Brogaard, Line Kai-Sørensen;
Denne rapport indeholder en livscyklusbaseret miljøvurdering (LCA) af behandling af deponeret shredderaffald. Livscyklusvurderingen blev udført for Miljøstyrelsen af DTU Miljø i perioden 2013-2014 som en del af en ydelsesaftale mellem Miljøstyrelsen og DTU om forskningsbaseret myndighedsbetjening...... in-den for affaldsområdet. Rapporten indgår i en større undersøgelse vedrørende bedre ressourceud-nyttelse af affald, hvori såvel den miljømæssige som den samfundsøkonomiske konsekvens for forskellige scenarier vedr. affaldshåndtering af shredderaffald, imprægneret træ, træ til genanven-delse samt...... fjernvarmerør undersøges. Livscyklusvurderingen blev udført vha. LCA-modellen EA-SETECH, som er udviklet af DTU Miljø til miljøvurdering af affaldssystemer. Livscyklusvurderingen blev udført i overensstemmelse med principperne for LCA, som beskrevet i DS/EN ISO-standard 14044. Afrapporteringen følger ISO...
Baisakhi Laha; Rajib Guha; Avijit Hazra
We report a case of neutropenic ulceration in a 42-year-old woman receiving azathioprine for pemphigus vulgaris. She developed multiple indolent ulcers involving the nose, neck, and back, after about 6–8 weeks following commencement of azathioprine 50 mg daily. The ulcers were large, disfiguring, dry, and with basal necrotic slough. They were painless and did not discharge pus. The absolute neutrophil count was severely depressed initially, but normalized following azathioprine withdrawal. Sw...
Jeurissen, M E; Boerbooms, A M; van de Putte, L B
Two patients with rheumatoid arthritis developed pancytopenia during treatment with azathioprine 100 mg daily. In one patient this side effect occurred after three weeks, in the other after eight weeks of treatment. Rapid fall of platelets in one patient necessitated platelet transfusion. In the other patient additional treatment with allopurinol was probably responsible for the toxic effect. Haematological side effects of azathioprine are discussed.
Huber Stephan M; Föller Michael; Geiger Corinna; Koka Saisudha; Bobbala Diwakar; Lang Florian
Abstract Background Azathioprine triggers suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and exposure of phosphatidylserine at the erythrocyte surface. Eryptosis may accelerate the clearance of Plasmodium-infected erythrocytes. The present study thus explored whether azathioprine influences eryptosis of Plasmodium-infected erythrocytes, development of parasitaemia and thus the course of malaria. Methods Human erythrocytes were infected in vitro with Plasmodium falcip...
Buhl, Kenneth Øhlenschlæger
Konflikten mellem Ukraine og Rusland udgør en trussel mod den internationale retsorden og dermed også hele den europæiske orden. Med henblik på at give et grundlag for at forstå omfanget af dette aspekt af konflikten behandles her lovligheden af nogle af de handlinger, som har været konfliktens...
Eiken, Pia Agnete; Langdahl, Bente Lomholt; Eiken, Frederik L;
The prevention of cancer treatment-induced bone loss in patients with prostatae cancer due to gonadotropin-releasing hormone (GnRH)-agonist, GnRH-antagonist and orchidectomi therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of non......-metastatic prostate cancer....
Nilsson, Tina; Sandström, Johanna
Anorexia nervosa är en svårbehandlad sjukdom med hög dödlighet (Fichter, Quadflieg & Hedlund,2006). Studiens syfte var att undersöka behandlares upplevelser av utmaningar och svårigheter i behandling av patienter med anorexia nervosa som vid behandlingsavslut har kvarvarande symtom, samt sätta upplevelserna i relation till ett patientperspektiv. Semistrukturerade intervjuer genomfördes med sju behandlare. Intervjumaterialet analyserades med Interpretative Phenomenological Analysis (IPA) o...
Lennard, L; Murphy, M F; Maddocks, J L
Severe anaemia is a rare, unexplained, side effect of azathioprine therapy. We report here such a case associated with a previously unreported abnormality in azathioprine metabolism. A 57 year old man on azathioprine therapy, for a presumed collagen vascular disease, developed severe megaloblastic anaemia. This resolved on cessation of azathioprine treatment. A very high concentration of an azathioprine metabolite, 6-thioguanine nucleotide, was found in the patient's red blood cells and this ...
Beckett, C. G.; Hill, P.; Hine, K R
We report the case of a 77-year-old man admitted nine days after being commenced on azathioprine with symptoms initially thought to be secondary to sepsis but in fact due to azathioprine hypersensitivity. He developed histologically proven cutaneous leucocytoclastic vasculitis following the re-introduction of azathioprine. We review the literature concerning adverse reactions to azathioprine and the problems of making the diagnosis as well as highlighting azathioprine as a novel cause of leuc...
Ytting, Henriette; Larsen, Fin Stolze
Autoimmune hepatitis is a relatively rare disease that may lead to rapidly progressing liver cirrhosis and even fulminant liver failure, if diagnosis and treatment is delayed or ineffective. Diagnosing the disease can be challenging, and one in five patients respond insufficiently to standard...
Oliel, Vibeke S.
Resumè Guillain Barrés syndrom er en autoimmum sygdom karakteriseret ved motorisk, sensorisk og autonom dysfunktion. I Danmark rammes omkring 80 personer i alle aldre årligt af sygdommen. Akut inflammatorisk polyradikoloneuropati rammer de perifere nervers nerveskeder og medfører progredierende...
von Plessen, Christian; Nielsen, Thyge L; Steffensen, Ida E; Larsen, Shuruk Al-Halwai; Taudorf, Ebbe
Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have similar prognosis and symptom burden. However, palliative care of patients with terminal COPD has been neglected in Denmark. We describe the symptoms of terminal COPD and suggest criteria for defining the palliative ph...... phase of the disease. Furthermore we discuss the prognostic and ethical challenges for patients, their families and their caregivers. Finally, we summarize the current evidence for palliative treatment of dyspnoea and ways to evaluate response to treatment....
Sørensen, Marie; Clausen, Helle Vibeke
systemic methotrexate. The patient with the living cervical ectopic pregnancy had stable vital signs during the period of treatment. The patient with the fetal pole was admitted with heavy vaginal bleeding and anaemia and was stabilised before treatment was initiated. She was stable throughout the...
von Plessen, Christian; Nielsen, Thyge L; Steffensen, Ida E;
Terminal chronic obstructive pulmonary disease (COPD) and advanced cancer have similar prognosis and symptom burden. However, palliative care of patients with terminal COPD has been neglected in Denmark. We describe the symptoms of terminal COPD and suggest criteria for defining the palliative...
ABSTRACT: Our understanding and treatment of children with autism have changed dramatically since Leo Kinner first formally documented this disorder in 1943. This paper looks at the treatment of autism in children. The main focus of the paper is Pharmacological treatment with anti-depressives (SSRI and TCA), anti-psycotics and the hormone secretin and dietary intervention with Gluten and/or Casein free diets. The conclusion of the paper is that we still need a lot more research in ord...
Boesby, L.; Kristensen, L.O.; Christensen, Niels Juel
Angiodysplasias account for 2-8% of GI-bleeding episodes. We describe a 75-year-old patient with a history of anaemia for 1 year before being diagnosed with multiple angiodysplasias in the GI-tract. The patient needed weekly blood transfusions until he started treatment with octreotide. After 4...... months of treatment the need for transfusions had decreased dramatically and faeces was negative for blood. Treatment was switched to long-acting octreotide (Sandostatin Lar). The case illustrates the usefulness of somatostatin analogues in the treatment of bleeding GI-angiodysplasias Udgivelsesdato...
Petersen, K R; Skouby, S O; Sidelmann, Johannes Jakobsen;
concentration of tissue plasminogen activator inhibitor. The ratio between thrombin-antithrombin-III-complexes and fibrin degradation products were unchanged signifying no effect of hormonal intake on the balance between thrombin formation and fibrin resolution. In conclusion, the dynamic balance between...... generation and resolution of fibrin was undisturbed during treatment with both hormonal compounds and our findings do not provide evidence for increased risk of thrombosis in normal women....
Lindholt, Christine S; Lindholt, Jes Sanddal; Lindholt, Jan
A 23 year-old woman with a nonsupporative pilonidal cyst was successfully treated causally with Nd-YAG laser, and without any recidivate after 9 months follow-up. The mechanism is presumed to be that YAG-laser has a wave-length of 1064 nm. Consequently, the wave penetration through the skin is de...... deeper than most other lasers before the energy is absorbed in melanin and oxyhaemoglobin, so the contents of the cyst can be reached and destroyed. The treatment could be a very attractive alternative to open surgery....
Lindholt, Christine S; Lindholt, Jes S; Lindholt, Jan
A 23 year-old woman with a nonsupporative pilonidal cyst was successfully treated causally with Nd-YAG laser, and without any recidivate after 9 months follow-up. The mechanism is presumed to be that YAG-laser has a wave-length of 1064 nm. Consequently, the wave penetration through the skin is de...... deeper than most other lasers before the energy is absorbed in melanin and oxyhaemoglobin, so the contents of the cyst can be reached and destroyed. The treatment could be a very attractive alternative to open surgery. Udgivelsesdato: 2008-Jun-23...
Nørgaard, Kirsten; Sohlberg, Anna; Goodall, Gordan
This study's aim was to project the long-term clinical and economic outcomes of continuous subcutaneous insulin infusion (CSII) treatment compared to multiple daily injections (MDI) in type 1 diabetes patients in Denmark....
Schousboe, K.; Rasmussen, K.; El Fassi, D.;
Metformin-associated lactate acidosis is rare but serious and characterized by metabolic acidosis and elevated lactate. We describe a single-institution experience of four cases in one year. Despite pH levels of 6.85 to 7.12 and lactate levels of 11-28 mmol/l three of the patients survived. Two o...... the patients had normal kidney function previous to hospitalization. Treatment includes fluid replacement, IV sodium bicarbonate and haemodialysis....
Thomsen, Maria Morandi; Thomsen, Stig Aaberg; Due, Pernille
A two-year-old patient was diagnosed with arthrogryposis because of inflected knees (15-20 degrees) and stiff hamstrings. All joints and reflexes were normal. Activities were described as age-appropriate, but the patient walked with inflected knees and increased lumbal lordosis. Physiotherapy and...
Andersen, Pia Juul; Kjeldsen, Anette Drøhse; Pedersen, Arne Toft
INTRODUCTION: Inverted papilloma is a benign sinonasal tumour and has a marked tendency to recur after surgical excision. The tumour may be associated with malignancy and during growth it may destroy surrounding tissue. The treatment is either lateral rhinotomy or endoscopic sinus surgery. The aim...... of the study was to describe the course of all patients treated with endoscopic sinus surgery at the ENT Department at Vejle County Hospital during the period 1 January to 31 December 1999. MATERIAL AND METHODS: Twenty-eight journals of patients diagnosed with inverted nasal papillomas were reviewed...... with carcinoma. We did not see any serious side effects to the treatment. DISCUSSION: Endoscopic sinus surgery in combination with Caldwell-Luc can be recommended as an alternative treatment to lateral rhinotomy in patients with inverted papillomas. Preoperative staging with CT or MR...
Vinter, Hanne; Nielsen, Henrik Ib
Therapy with tumour necrosis factor-alfa inhibitors is widely used in various inflammatory disorders, but adverse events from severe infections with intracellular pathogens may occur. We describe two cases of severe pulmonary legionellosis in patients treated with infliximab for Crohn's disease a...... psoriasis, respectively. We conclude that legionella infections are probably more frequent in patients receiving immunosuppressive therapy with tumour necrosis factor-alfa inhibitors than in the background population. Udgivelsesdato: 2009-Jan-19...
Oczachowska-Kulik, Anne; Lund, A M; Skovby, F;
Cystinosis is a rare, autosomal recessive disease with cystine deposits in different tissues. First signs come from kidneys and eyes, but during progression of the disease other organs can also be affected. Previously, patients with cystinosis had a very poor prognosis, but it is now considerably...... improved due to new methods of treatment. The purpose of this paper is to give a brief review of the disease and discuss the significant improvement of the prognosis, which has been achieved by specific medical treatment with cystine-depleting agents, and, if needed, by kidney transplantation....
Natekar, Aniket; Pupco, Anna; Bozzo, Pina; Koren, Gideon
Question Quite a few of my female patients with rheumatic diseases and inflammatory bowel disease are using azathioprine. They are afraid to take a “cancer drug” during pregnancy. What is known about the risks?
A 33-year-old housewife with a 14-year history of relapsing polyneuropathy of unknown cause who has apparently responded to azathioprine therapy is described. The place of this form of treatment in idiopathic polyneuropathy is discussed.
Watts, G. F.; Corston, R.
A patient with myasthenia gravis is described who exhibited hypersensitivity including an apparent acute exacerbation of the underlying disorder when treated with azathioprine. 6-mercaptoprine (6-MP) also produced hypersensitivity which, in contrast, did not manifest as a myasthenic exacerbation.
Tawfik Khoury; Ollech, Jacob E; Shmuel Chen; Meir Mizrahi; Meir Shalit
Underdiagnosis of drug-induced fever leads to extensive investigation and prolongation of hospitalization, and may lead to multiple unnecessary invasive procedures and a wrong diagnosis. Azathioprine is a widely used immunosuppressive drug. We report a case of a 53-year-old female patient diagnosed with autoimmune hepatitis treated with azathioprine, who presented to the emergency room with a 6-wk history of fever and chills without other associated symptoms. Since the patient’s fever ...
Scherbak D; Wyckoff R; Singarajah C
A 58-year-old Caucasian man treated with azathioprine to prevent rejection of an orthotopic liver transplant, presented to the Carl Hayden VA Medical Center with rapid respiratory decline and appeared septic. He required urgent intubation, mechanical ventilator support and empiric antibiotics. His clinical picture and imaging studies were consistent with acute respiratory distress syndrome; however, extensive infectious work up failed to reveal an offending organism. Review of his current med...
Lødding, Berit; Vibe, Nils
Denne rapporten skal bidra til å forklare forskjeller mellom skoler når det gjelder andeler av elevene som over tid har rapportert om mobbing, urettferdig behandling eller diskriminering i Elevundersøkelsen. I hvilken grad programmer for å forebygge mobbing og bedre læringsmiljøet har effekt, er også en del av oppdraget fra Utdanningsdirektoratet. Hva elevene forstår med begrepene mobbing, urettferdig behandling og diskriminering og i hvilken grad de klarer å reflektere rundt begrepene, er og...
Pitt, P I; Sultan, A H; Malone, M; Andrews, V.; Hamilton, E. B.
Three out of 41 patients treated with azathioprine and low-dose corticosteroids from 1976 to 1983 developed non-Hodgkin's lymphoma. This strikingly high incidence of lymphoma may be a reflection of long-term use of azathioprine.
Colombel, Jean Frédéric; Sandborn, William J; Reinisch, Walter;
The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown.......The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown....
Kjær, Per; Eirikstoft, Heidi; Ris Hansen, Inge
anbefalinger til: • overordnet klassifikation af nakkebesvær • identificering af tegn på alvorlig patologi (røde flag) • identificering af personer med risiko for at udvikle uhensigtsmæssige copingstrategier i forbindelse med nakkebesvær • identificering af personer med risiko for at miste tilknytning til...... arbejdsmarked (gule flag) • identificering af mulige differentialdiagnoser • klassificering af almindelige lidelser i nakken med henblik på specifik behandling Patienter Retningslinjen giver anbefalinger om fysioterapeutisk undersøgelse og diagnostik af personer med uspecifikke nakkesmerter med eller uden...
Fonseca, V.; Havard, C W
A 52 year old man with myasthenia gravis and normal liver function was treated with neostigmine, prednisolone and azathioprine. Three years after starting azathioprine he developed clinical evidence of portal hypertension. A liver biopsy showed nodular regenerative hyperplasia (NRH). The development of NRH following azathioprine treatment in a patient with myasthenia gravis strengthens the case for a causal role of azathioprine in producing NRH and portal hypertension.
Föreliggande studie är dels ett led i att kvalitetssäkra EMDR (Eye Movement Desensitization and Reprocessing) som behandlingsmetod för barn och ungdomar och dels att utröna om behandlingen bidragit till ett förbättrat mående. EMDR som behandlingsmetod för barn och ungdomar har stöd i kontrollerade studier, men ytterligare forskning behövs. I den här studien deltog åtta barn och ungdomar med varierande diagnoser, vilka fått EMDR-behandling i barn- och ungdomspsykiatrisk öppenvård. Behandlingen...
Kaushal K Verma; G Sethuraman; M Kalavani
Background: Azathioprine in daily doses has been shown to be effective and safe in the treatment of Parthenium dermatitis. Weekly pulses of azathioprine (WAP) are also effective, but there are no reports comparing the effectiveness and safety of these two regimens in this condition. Aims: To study the efficacy and safety of WAP and daily azathioprine in Parthenium dermatitis. Methods: Sixty patients with Parthenium dermatitis were randomly assigned to treatment with azathioprine 300 mg weekly...
Fernando Gomollón; Santiago García López
Azathioprine is Currently the key drug in the maintenance treatment of inflammatory bowel diseases. However, there are still some practical issues to be resolved: one is how long we must maintain the drug. Given that inflammatory bowel diseases are to date chronic, non-curable conditions, treatment should be indefinite and only the loss of efficacy or the appearance of serious side effects may cause withdrawal. As regards to efficacy and their maintenance over time, evidence supports the continuous usefulness of the drug in the long term: in fact its withdrawal very substantially increases the risk of relapse. About side effects, azathioprine is a relatively well tolerated drug and even indefinite use seems safe. The main theoretical risks of prolonged use would be the myelotoxicity, hepatotoxicity, and the development of cancer. In fact, serious bone marrow suppression or serious liver damage are uncommon, and can be minimized with proper use of the drug. Recent metanalysis suggests that the risk of lymphoma is real, but the individual risk is rather low, and decision analysis suggests a favorable benefit/risk ratio in the long term. Therefore, in patients with inflammatory bowel diseases in whom azathioprine is effective and well tolerated, the drug should not be stopped. This recommendation concerns the use of azathioprine as a single maintenance drug, and is not necessarily applicable to patients receiving concomitant biological therapy.
Frederiksen, A.M.; Ewers, B.; Gasbjerg, A.; Marckmann, P.; Hansen, Jesper Melchior
(74%) were treated with triple-drug immunosuppression, in most cases (46%) with the combination prednisolone-ciclosporine-azathioprine. During recent years, azathioprine has been increasingly replaced by mycophenolate mofetil. CONCLUSIONS: The majority of kidney-transplanted patients with a...
kan indebære at behandle en patient med en psykisk lidelse ligeværdigt og som person. Teksten kommer også ind på begrebet "urørlighedszoner" som udtryk for det meget konkrete og private råderum, som mennesker, der har opnået en vis alder, tager for givet. Teksten giver eksempler på krænkelser af...
Steffensen, Maria Charlotte; Mægbæk, Merete Lund; Laurberg, Peter;
Treatment with dopamin agonists, particularly cabergoline, is the primary and preferred therapy for prolactinomas and symptomatic hyperprolactinaemia due to its effectiveness and tolerability. However, an association has been demonstrated between fibrotic heart valve disease and high-dose dopamin...
Johansen, E C; Johansen, J B; Døssing, H
Angioneurotic oedema secondary to angiotensin-converting enzyme (ACE) inhibitors is a rare condition, but it is a side effect which is likely to be seen more frequently because of the increased use of these drugs in the treatment of heart failure and hypertension. We report two cases which...... illustrate problems in the diagnosis and management of this life-threatening condition, and also demonstrate that angioedema re-occurs if the ACE inhibitor is not discontinued. If angioedema is suspected, therapy with any angiotensin converting-enzyme inhibitor should be discontinued promptly, respiratory...
Lakshmi, C S; Reddy, M N
Four simple and sensitive visible spectrophotometric methods (A-D) have been described for the assay of azathioprine (ATP) either in pure form or in pharmaceutical formulations. Methods A and B are based on the oxidation of ATP with excess N-bromosuccinimide (NBS) or chloramine-T (CAT) and determining the consumed NBS or CAT with a decrease in colour intensity of celestine blue (CB) (method A) or gallocyanine (GC) (method B), respectively. Methods C and D are based on the diazotisation of reduced azathioprine (RATP) with excess nitrous acid and estimating either the consumed nitrous acid (HNO(2)) with cresyl fast violet acetate (CFVA) (method C) or by coupling reaction of the diazonium salt formed with N-1-naphthyl ethylene diamine dihydrochloride (NED) (method D). All of the variables have been optimized and the reactions presented. The concentration measurements are reproducible within a relative standard deviation of 1.0%. Recoveries are 99.2-100.3%. PMID:18967434
Eight patients with intractable Reiter's disease were entered into a double blind, placebo controlled, crossover study of azathioprine versus placebo--each patient serving as his own control. Drug therapy was administered for 16 weeks, patients receiving azathioprine (eight weeks) or placebo (eight weeks) in random order. Azathioprine was given as 1 mg/kg body weight for the first month and 2 mg/kg body weight for the second month. Six individuals completed both arms of the crossover. One wit...
Kim, Mi Jin; Choe, Yon Ho
Azathioprine is the most common drug used to maintain clinical remission in inflammatory bowel disease. This drug is also important as a steroid-sparing agent in steroid-dependent and chronically active inflammatory bowel disease. Nevertheless, many questions remain concerning the optimal treatment regimens of azathioprine. The dose of azathioprine has to be reduced or the therapy has to be discontinued frequently because of drug-induced toxicity. In this review, we discuss monitoring of thio...
Hawthorne, A. B.; Logan, R. F.; Hawkey, C. J.; Foster, P. N.; Axon, A T; Swarbrick, E T; Scott, B B; Lennard-Jones, J E
OBJECTIVE--To determine whether azathioprine can prevent relapse in ulcerative colitis. DESIGN--One year placebo controlled double blind trial of withdrawal or continuation of azathioprine. SETTING--Outpatient clinics of five hospitals. SUBJECTS--79 patients with ulcerative colitis who had been taking azathioprine for six months or more. Patients in full remission for two months or more (67), and patients with chronic low grade or corticosteroid dependent disease (12) were randomised separate...
Bakgrund: Våra levnadsvanor har en central roll vid uppkomsten och utvecklandet av diabetes. Det primära vid vård av personer med typ 2 diabetes är att stödja egenvården. Målet med behandling av diabetes är att behålla en god livskvalitet samt förhindra komplikationer orsakade av sjukdomen. Syfte: Syftet var att undersöka den egenvård som personer med typ 2 diabetes utför. Metod: En kvalitativ intervjustudie med semistrukturerade frågor användes. Tio personer med typ 2 diabetes intervjuades....
Nilsen, Fredrik Bø
Dette arbeidet har undersøkt to materialer, zeolitten SSZ-13 og det zeotype materialet SAPO-34, begge med CHA-topologi. Materialene ble syntetisert ut i fra tidligere utarbeidete prosedyrer før de ble hydrotermisk behandlet. Betingelsene under behandlingen var temperaturer på 600⁰C og 700⁰C med en konstant vanntilførsel på 6 ml/time over 4 timer. Før og etter behandling ble prøvene karakterisert med XRD, N2 adsorpsjon og BET beregninger, SEM, EDS, FT-IR med CO og pyridin som probemolekyler og...
(1) Allopurinol increases the haematological toxicity of azathioprine and mercaptopurine, with a risk of pancytopenia. (2) Combination of allopurinol with azathioprine or mercaptopurine should be avoided. PMID:11503788
Full Text Available SAMMENDRAGDenne undersøkelsen fokuserer på kjønnsforskjeller blant mannlige og kvinnelige misbrukere med hensyntil sosiodemografi, behandlingshistorie og rusmiddelmisbruk. 149 klienter (51 kvinner ble rekruttert fra enbehandlingsinstitusjon. Flere kvinner enn menn er uten arbeid, og lever på ulike former for sosial støtte.Relativt sett få kvinner har mottatt behandling for sitt rusproblem tidligere, inkludert avrusning. De harkortere misbrukskarrierer før de kommer til behandling, og drikker mindre alkohol enn menn. Imidlertid erflere av dem blandingsmisbrukere, hyppigst kombineres alkohol og benzodiazepiner.Vandeskog A, Skutle A. Gender differences among substance abusers in treatment.Nor J Epidemiol ENGLISH SUMMARYThe present study focuses on gender differences regarding sociodemography, treatment history, andalcohol and drug use among male and female abusers. One hundred and forty-nine subjects (51 womenwere recruited from a clinical setting. More women than men are unemployed and living on different formsof social benefits. Relatively few women have been in treatment earlier, including detoxification units.They have shorter abuse careers before entering treatment, and consume less alcohol than men. Morewomen are multiple substance abusers, most frequently combining alcohol and benzodiazepines.1996; 6 (1: 115-122.
Azathioprine has been used in rheumatology for more than twenty years. Indications are collagen diseases with multiorgan involvement, where co-medications are frequently necessary. We describe a patient suffering from pancytopenia following a combination therapy of azathioprine and allopurinol because of lupus erythematodes and diabetic nephropathy with hyperuricemia. PMID:15517303
Jong, Dirk de; Goullet, M.; Naber, A.H.J.
OBJECTIVE: In clinical trials 0-15% of patients discontinued azathioprine due to side effects. The aim of this study was to assess the rate of side effects leading to discontinuation of azathioprine and to determine predictive factors for discontinuation. DESIGN: A retrospective cohort analysis of c
Knut Skyberg; Knut Skulberg
SAMMENDRAGBasert på to intervensjonsforsøk rettet mot helseeffekter i hud og øvre luftveier før og etter inneklimatiltak,drøftes erfaringer med design, metoder og analyse av data. Intervensjonene som ble prøvet ut varantistatisk behandling av dataskjerm (n=117) og storrengjøring i kontormiljø (n=104). Det ble måltstøvkonsentrasjon under vanlig arbeid med direktevisende partikkelteller. Ved støvkonsentrasjoner > 50μg/m 3 hadde tiltakene effekt. Antistatisk behandling av skjermen førte til red...
Christensen, Kaj Aage Sparle
tendens. Samlet set tyder evalueringen på, at personer med lette og moderate depressive enkeltepisoder behandles lige effektivt i privat og offentlig psykologordning. Henvisning til den gratis offentlige ordning var imidlertid forbundet med længere ventetid på behandling og længere varighed af eventuel...... I 2004 blev det i forbindelse med overenskomstforhandlinger mellem Sygesikringens Forhandlingsudvalg og Dansk Psykologforening aftalt at afholde udgifterne til evaluering af to 1-årige forsøg med behandling af personer med lette og moderate depressioner i Århus og Fyns Amter. Behandlingstilbudet...... der en gradvis forøgelse af ventetiden på behandling i begge amter, mest udtalt i Århus. Den gennemsnitlige ventetid på behandling var 25.3 dage på Fyn og 51.2 dage i Århus. Tilsvarende var patienterne gennemsnitligt sygemeldt 83.8 dage på Fyn og 117.5 dage i Århus Amt. Patienterne på Fyn modtog i...
Andersson, Linda; Lövström, Jennifer
Bakgrund: Bipolär sjukdom är en kronisk sjukdom som karaktäriseras utav förändringar i patientens aktivitetsnivå och stämningsläge. Dessa episoder benämns som mani-, hypomani- och depressionsepisoder. Behandling och omvårdnad fokuseras på att lindra symtom. Syfte: Syftet med denna litteraturstudie var att belysa patienters erfarenheter av att leva med bipolär sjukdom. Metod: I litteraturstudien användes 8 kvalitativa vetenskapliga artiklar. Dessa har sammanställts och analyserats med inspirat...
En stor del (uppskattningsvis 30%) av primärvårdens patienter lider av psykisk ohälsa. Genom införandet av Rehabgarantin garanteras personer med ångest och depression evidensbaserad samtalsbehandling bland annat i form av kognitiv beteendeterapi. En enkätundersökning visar att behandlare inom primärvården i Jämtland ger en behandling som influeras av andra terapeutiska inriktningar tillsammans med KBT och att de anser att KBT i sig är en alltför begränsad metod för att möta behoven hos primär...
Kaushal K Verma
Full Text Available Background: Azathioprine in daily doses has been shown to be effective and safe in the treatment of Parthenium dermatitis. Weekly pulses of azathioprine (WAP are also effective, but there are no reports comparing the effectiveness and safety of these two regimens in this condition. Aims: To study the efficacy and safety of WAP and daily azathioprine in Parthenium dermatitis. Methods: Sixty patients with Parthenium dermatitis were randomly assigned to treatment with azathioprine 300 mg weekly pulse or azathioprine 100 mg daily for 6 months. Patients were evaluated every month to assess the response to treatment and side effects. Results: The study included 32 patients in the weekly azathioprine group and 28 in the daily azathioprine group, of whom 25 and 22 patients respectively completed the study. Twenty-three (92% patients on WAP and 21 (96% on daily azathioprine had a good or excellent response. The mean pretreatment clinical severity score decreased from 26.4 ± 14.5 to 4.7 ± 5.1 in the WAP group, and from 36.1 ± 18.1 to 5.7 ± 6.0 in the daily azathioprine group, which was statistically significant and comparable (P = 0.366. Patients on WAP had a higher incidence of adverse effects (P = 0.02. Limitations: The study had a small sample size and the amount of clobetasol propionate used in each patient was not determined, though it may not have affected the study outcome due to its comparable use in both groups. Conclusions: Azathioprine 300 mg weekly pulse and 100 mg daily dose are equally effective and safe in the treatment of Parthenium dermatitis.
Det finnes et ikke ubetydelig antall pasienter med tannbehandlingsvegring i Norge. Disse pasientene har ikke noe reelt behandlingstilbud innenfor det offentlige helsevesenet i dag. Vi har kartlagt omfanget av tannbehandlingsvegring og behov for et styrket tilbud til disse pasientene ved hjelp av et spørreskjema sendt ut til samtlige tannleger i Aust-Agder. Omfanget av behandlingsvegring tilsvarer i vår studie omtrent omfanget av dette i andre studier fra inn-og utland. Tannlegenes behandl...
Choonhakarn, Charoen; Chaowattanapanit, Suteeraporn
Hypersensitivity to azathioprine can manifest with a wide clinical spectrum. Azathioprine-induced Sweet's syndrome (SS) is rare and usually overlooked because it can mimic disease exacerbation and sepsis. This study aims to characterize the clinical findings of azathioprine-induced SS. A retrospective analysis of the records of three patients diagnosed with azathioprine-induced SS and a review of the relevant English-language published work was performed. Twelve (71%) of the 17 patients were male, ranging 9-89 years in age (mean, 47.2). The time of onset after starting azathioprine was 5-28 days (mean, 13.3). The most common associated disease was inflammatory bowel disease including ulcerative colitis and Crohn's disease (76%). The clinical features typically consisted of fever and classic rash of SS with pustules and vesicles. The lesions occurred most commonly on the face and trunk. Systemic involvement was rare and no hypotension or shock was reported as seen in azathioprine hypersensitivity syndrome. Thiopurine methyltransferase activity is not predictive of this type of adverse effect. Most patients dramatically responded to systemic corticosteroids. Azathioprine-induced SS may be underdiagnosed because it can be easily misinterpreted as inflammatory bowel disease-associated skin eruption. Patients with inflammatory bowel disease may be at higher risk of this condition. Early recognition and drug withdrawal can decrease morbidity of the patients. PMID:23294021
Kronborg, Christian; Kjær, Trine; Bech, Mickael
Dronning Ingrids Hospital i Nuuk kan organiseres, herunder foreslået hvordan en enhed ved Dronning Ingrids Hospital kan samarbejde med Rigshospitalet i København om behandlingen af patienter med behov for dialyse. Det foreslås således, at opstart af dialysebehandlingen, som nu, skal foregå på...... Rigshospitalet, hvorefter behandling og kontrol foregår på Dronning Ingrids Hospital. På baggrund af danske data om forekomsten af behandlingskrævende nyresvigt vurderes det, at der i dag er færre grønlandske patienter i dialysebehandling end forventet. En hjemtagning af behandlingen kan muligvis ændre på dette...... andelen overstige 60 % (mod ca. 40 % i dag). Hvis andelen af patienter med behov, som faktisk tager imod behandling, fastholdes over de næste 10 år, hvis behandlingen fortsat skal foregå som nu (ca. 40 %), mens andelen øges ved en hjemtagning, vil behandling på Dronning Ingrids Hospital være forbundet med...
Harwood, C.A.; Attard, N R; O'Donovan, P.; Chambers, P; Perrett, C. M.; Proby, C M; McGregor, J. M.; Karran, P.
The immunosuppressant azathioprine is used to prevent graft rejection after organ transplantation. To investigate whether azathioprine-associated mutagenesis contributes to the high incidence of skin tumours in organ transplant recipients (OTRs), we analysed PTCH gene mutations in 60 basal cell carcinomas (BCC); 39 from OTRs receiving azathioprine and 21 from individuals never exposed to azathioprine. PTCH was mutated in 55% of all tumours, independent of azathioprine treatment. In both the a...
Miller, Jonathan; Lee, Nicole; Sami, Naveed
Histiocytoid Sweet syndrome (HSS) is a rare histologic variation of Sweet syndrome (SS) predominantly exhibiting mononuclear histiocytoid cells instead of neutrophils. We report a 22-year-old woman with HSS, who, after minimal improvement with colchicine and dapsone, had significant improvement of her cutaneous eruption and systemic symptoms following empiric treatment with azathioprine. Since azathioprine has historically been known to cause SS, this case highlights a previously unreported treatment response for the histiocytoid variant. PMID:26436977
Miller, Jonathan; Lee, Nicole; Sami, Naveed
Histiocytoid Sweet syndrome (HSS) is a rare histologic variation of Sweet syndrome (SS) predominantly exhibiting mononuclear histiocytoid cells instead of neutrophils. We report a 22-year-old woman with HSS, who, after minimal improvement with colchicine and dapsone, had significant improvement of her cutaneous eruption and systemic symptoms following empiric treatment with azathioprine. Since azathioprine has historically been known to cause SS, this case highlights a previously unreported t...
Kirk, A P; Lennard-Jones, J E
A double-blind controlled trial of azathioprine in a dose of 2-2.5 mg/kg body weight over six months was conducted among 44 patients with active chronic ulcerative colitis. Three patients treated with placebo did not complete the trial because their disease became so severe that colectomy was performed. Among patients who completed the trial the mean dose of prednisolone necessary to control the disease decreased in those treated with azathioprine and those treated with placebo; the reduction...
Szawlowski, P W; Maddocks, J L
The effect of interleukin-2 on the response of the human MLR to azathioprine was studied. Azathioprine (36 microM) inhibited the MLR by 86% and interleukin-2 (25%) stimulated the MLR by 99%. Only partial relief (16%) of azathioprine (36 microM) inhibition was found in the interleukin-2 treated MLR compared with azathioprine treatment alone. However, [3H]-thymidine incorporation by azathioprine (36 microM) + interleukin-2 treated MLR was 4.3 times greater than that exposed to azathioprine alon...
Ridder, Hanne Mette Ochsner
Musikterapi er forholdsvist velkendt i forhold til mennesker med neurologiske problemstillinger som erhvervet hjerneskade eller demens. Delkapitlet her giver et bredt helserelateret og udviklingspsykologisk perspektiv på neurologiske problemstillinger som følge af forandringer i hjernen. Derfor i...
Cleary, Brian J
BACKGROUND: Azathioprine (AZA) is used during pregnancy by women with inflammatory bowel disease (IBD), other autoimmune disorders, malignancy, and organ transplantation. Previous studies have demonstrated potential risks. METHODS: The Swedish Medical Birth Register was used to identify 476 women who reported the use of AZA in early pregnancy. The effect of AZA exposure on pregnancy outcomes was studied after adjustment for maternal characteristics that could act as confounders. RESULTS: The most common indication for AZA use was IBD. The rate of congenital malformations was 6.2% in the AZA group and 4.7% among all infants born (adjusted OR: 1.41, 95% CI: 0.98-2.04). An association between early pregnancy AZA exposure and ventricular\\/atrial septal defects was found (adjusted OR: 3.18, 95% CI: 1.45-6.04). Exposed infants were also more likely to be preterm, to weigh <2500 gm, and to be small for gestational age compared to all infants born. This effect remained for preterm birth and low birth weight when infants of women with IBD but without AZA exposure were used as a comparison group. A trend toward an increased risk of congenital malformations was found among infants of women with IBD using AZA compared to women with IBD not using AZA (adjusted OR: 1.42, 95% CI: 0.93-2.18). CONCLUSIONS: Infants exposed to AZA in early pregnancy may be at a moderately increased risk of congenital malformations, specifically ventricular\\/atrial septal defects. There is also an increased risk of growth restriction and preterm delivery. These associations may be confounded by the severity of maternal illness.
Vestergaard, T; Bygum, A
Summary Background. Determining thiopurine methyltransferase (TPMT) genotype and phenotype before azathioprine treatment predicts which patients are most likely to develop myelosuppression. Aim. To evaluate the course of azathioprine treatment in people with TPMT heterozygosity and whether this d...
Bunch, T W; Worthington, J W; Combs, J J; Ilstrup, D M; Engel, A G
A controlled, prospective, double-blind, therapeutic trial of azathioprine was conducted in the initial therapy of polymyositis. Sixteen patients received 60 mg prednisone per day plus either azathioprine (2 mg/kg of body weight per day) or placebo for a period of 3 months. Creatine phosphokinase (CPK) levels fell to normal slightly sooner in the placebo group, but not significantly so. The azathioprine group did not become significantly stronger (P = 0.58) and did not manifest significantly greater improvement of histopathologic features of muscle (P = 0.80) than the placebo group. Initial CPK elevations were significantly related to the degree of muscle inflammation (P = 0.037), but this was not the case at 3 months (P greater than 0.05). Normalization of the CPK could not be equated with disease control. Type II fiber atrophy, attributed to steroid therapy, was more marked in women than in men (P less than 0.03). PMID:6986827
Berrebi, W; Chaussade, S; Bruhl, A L; Pariente, A; Valleur, P; Hautefeuille, P; Couturier, D
Ileoanal anastomosis is a surgical procedure performed in patients with ulcerative colitis. In a small number of patients operated on for ulcerative colitis, Crohn's disease occurs in the reservoir, mimicking pouchitis, and may lead to pouch excision and to a permanent terminal ileostomy. Two patients with recurrent Crohn's disease in the reservoir after ileoanal anastomosis were treated with azathioprine for 18 and 24 months, respectively. Azathioprine induced a complete clinical and endoscopic remission. These two observations suggested that immunosuppressive drugs were a good option for permanent ileostomy in cases of recurrence of Crohn's disease in the reservoir after ileoanal anastomosis. PMID:8344116
Full Text Available Sprague-Dawley rats given azathioprine in the diet for 3 to 4 weeks developed severe liver damage. Elevations of serum alkaline phosphatase and gamma-glutamyl transpeptidase activities were associated with increased hepatic glucose 6-phosphate dehydrogenase levels and decreased liver glucose 6-phosphatase activities, i.e., conditions which were commonly observed in various hepatotoxin-induced liver injuries. Light and electron microscopic observations revealed centrolobular necrosis with large scars and the proliferation of the mitochondria and rough endoplasmic reticulum. This model could be used to study the mechanisms of azathioprine-induced liver damage and its prevention.
Pedersen, E G; Pottegård, A; Hallas, J;
The association between use of azathioprine and risk of non-melanoma skin cancer (NMSC) in patients with myasthenia was evaluated in a nationwide setting. Treatment of autoimmune myasthenia frequently involves long-term exposure to immunosuppressants, including azathioprine. Use of azathioprine...
The therapeutic effects of azathioprine were evaluated in a murine graft-versus-host (GVH) model. A single high dose (200 mg/kg) of azathioprine, administered to FI recipients 2 to 3 days after the injection of parental spleen cells, abrogated the ensuing GVH reaction. Lower doses of the drug, even when injected over an extended period of time (14 days), were found to be ineffective. However, high doses of azathioprine failed to protect when FI recipients were sublethally irradiated or injected with cyclophosphamide before GVH induction, and even the transfer of syngeneic FI spleen cells immediately after irradiation failed to alter this outcome. Further analysis of the changes that occurred in sublethally irradiated recipients revealed that the protective effect of azathioprine on CBA leads to (CBA x C57BL)FI GVH reaction was totally abrogated by doses of irradiation as low as 200 rad. Further experiments in which death was used as an indicator of GVH disease showed that lethality could not be reversed in sublethally irradiated FI recipients by the transfer of syngeneic FI spleen cells unless approximately 10 days were allowed to elapse between syngeneic reconstitution and GVH induction. Since syngeneic FI cells from spleen, lymph node, or bone marrow all behaved similarly, it seems likely that the increased severity of GVH reaction induced by prior immunosuppression may not be attributable to a simple cell deletion event.
The therapeutic effects of azathioprine were evaluated in a murine graft-versus-host (GVH) model. A single high dose (200 mg/kg) of azathioprine, administered to FI recipients 2 to 3 days after the injection of parental spleen cells, abrogated the ensuing GVH reaction. Lower doses of the drug, even when injected over an extended period of time (14 days), were found to be ineffective. However, high doses of azathioprine failed to protect when FI recipients were sublethally irradiated or injected with cyclophosphamide before GVH induction, and even the transfer of syngeneic FI spleen cells immediately after irradiation failed to alter this outcome. Further analysis of the changes that occurred in sublethally irradiated recipients revealed that the protective effect of azathioprine on CBA leads to (CBA x C57BL)FI GVH reaction was totally abrogated by doses of irradiation as low as 200 rad. Further experiments in which death was used as an indicator of GVH disease showed that lethality could not be reversed in sublethally irradiated FI recipients by the transfer of syngeneic FI spleen cells unless approximately 10 days were allowed to elapse between syngeneic reconstitution and GVH induction. Since syngeneic FI cells from spleen, lymph node, or bone marrow all behaved similarly, it seems likely that the increased severity of GVH reaction induced by prior immunosuppression may not be attributable to a simple cell deletion event
Glesner, Matilde Kanstrup; Ocias, Lukas Frans; Larsen, Thomas Stauffer; Pedersen, Court
A 33-year-old man treated with azathioprine for 12 years for Crohn's disease presented with headache, nausea and vomiting accompanied by difficulty in putting words together and slight mental confusion. Prednisolone and antibiotics were without effect. MRI of the brain showed multiple focal lesions...
Bylund, Jennie; Johansson, Charlotte
Syfte. Att jämföra strålrelaterade hudbiverkningar efter behandling av bröstcancer mellan kvinnor som använt en nyutvecklad bh innehållande ullfrotté, och kvinnor som inte använt bhn. Bakgrund. Bröstcancer är den vanligaste cancerdiagnosen för kvinnor i världen, där behandlingen främst utgörs av kirurgi med kompletterande cytostatika- och strålbehandling. En av de vanligaste biverkningarna vid strålbehandling är hudreaktioner. Design. Kvantitativ deskriptiv tvärsnittsstudie. Metod. Enkätstud...
Burgdorf, Stefan K; Eriksen, Jens Ravn; Gögenür, Ismail
Possibly improved treatment of colorectal cancer by sentinel lymph node mapping Prognosis for colorectal cancer is dependent on radical surgical intervention. Chemotherapy in patients with advanced disease has improved the survival. A considerable proportion of the patients going through radical...... surgery will subsequently relapse. Adjuvant chemotherapy is reserved for patients with lymph node metastases, why undetected malignant lymph nodes will result in understaging and exclusion from the possible benefit of adjuvant chemotherapy. With sentinel lymph node mapping it may be possible to detect and...
Gerbild, Helle Nygaard
or cure, and the specific type of CAM used. The experiences of the patients were connected with these factors. The results of this study are that infrequent clients are not positioned towards CAM specificly for diabetes. The established clients using CAM were posited towards CAM supplying...... established clients, however, are positioned as user of both complementary and alternative medicine and conventional treatments, such as biological, homeopathic, and traditional Chinese medicine. The main factors that drive them to this are the aim, the hope, the belief, and knowledge how to cure diabetes....... Conclusion: The study shows that the decisive difference of how diabetics are positioned as to complementary and alternative self-care is the way in which they have the strength and hope, believe and knowledge of how to cure disease which by people in general is regarded as chronic....
Gybel, Mikkel; Kristensen, Kjeld; Roseva-Nielsen, Natasha
Pulmonary embolism (PE) as the direct cause of cardiac arrest is well known but probably under-diagnosed. Treatment of menorrhagia with antifibrinolytics is a well documented treatment modality and it is considered safe although thromboembolic complications have been reported. We describe a case of...
Thorsdal-Hjeds, Michala Lykke; Lund, Kira; Elling, Fenja Sidse Rudkjøbing; Nielsen, Sif Hummelgaard
Ritalin is the most common medication used for attention deficit hyperactivity disorder (ADHD) and figures show a radical increase in the production of this particular drug within the last decade, leading to the conclusion that more people - especially children showing erratic behavior - are being diagnosed with ADHD and treated for it medically. In opposition to this development of medicating an increasing number of children, this report focuses upon diet and exercise as alternative metho...
Meyer, Lars Christian; Godballe, Christian
Laryngomalacia is the most common cause for congenital stridor. The stridor is caused by collapse of supraglottic structures during inspiration. Two severe cases treated with laser-assisted supraglottoplasty are presented. Our cases as well as the literature describe good effect of the treatment...
Andersen, Ase Bengård; Lillebæk, Troels; Bang, Didi;
Development of new drugs for the treatment of drug sensitive and drug resistent tuberculosis is badly needed. Substantial progress has been made in the field and presently six new drug components are in clinical phase I and II trials. Drugs approved for other indications e.g. newer fluoroquinolones...
Eiken, Pia Agnete; Langdahl, Bente Lomholt; Eiken, Frederik L;
The prevention of cancer treatment-induced bone loss in patients with prostate cancer due to gonadotropin-releasing hormone (GnRH)-agonist, GnRH-antagonist and orchidectomi therapy has a high priority. We present an algorithm for the prevention and treatment of osteoporosis during treatment of non......-metastatic prostate cancer....
Svendsen, Jesper Hastrup; Madsen, J K; Saunamäki, K I;
, systolic blood pressure and rate-pressure product were similar in the two groups. At maximum workload the streptokinase treated patients had a significantly higher median maximal heart rate than controls (136 vs. 126 min-1; p <0.01) but only a trend towards higher systolic blood pressure was seen (175 vs....... 163 mmHg; p = 0.09). Rate-pressure product at maximal exercise was 23.620 vs. 20.100 mmHg x min-1; p <0.01). A significantly smaller number of patients in the streptokinase group had exercise capacity below 50 W (0% vs. 15.9%; p <0.01). In conclusion: patients treated with intravenous streptokinase...... for acute myocardial infarction reach both higher heart rates and rate-pressure products at maximum workload than their controls thus indicating that the beneficial effects of thrombolysis after acute myocardial infarction are reflected in an improved heart rate response during exercise....
Drivsholm, Thomas Bo; Snorgaard, Ole
The organization of treatment and control of type 2 diabetic patients in Denmark has undergone a major development within the last decade. From being based on local hospital guidelines, treatment and control have moved towards a more organized collaboration between primary and secondary care based...... on common national guidelines. Quality indicators from primary and secondary care are collected routinely, and gradually an increasingly precise depiction is documented in the National Indicator Project....
Due-Tønnessen, Maria; Erdal-Aase, Ragna
This is a qualitative study based on interviews with 12 psychotherapists, that each have significant experience of individual psychotherapy with patients with psychosis. The aim of the study is to examine how psychosis is understood and how patients with psychosis are currently treated by therapists in Norway. The interviews were analysed using hermeneutic-fenomenological methods with elements from Consensual Qualitative Research. The results show a broad range both in the therapists’ underst...
Tinnitus is a common and severe disorder presenting big health issues for the many people affected. The fact that not all people are affected by their tinnitus, have been a puzzle for scientists. This has led to an expanded psychological view of tinnitus over time. Tinnitus as a functional disorder, is first of all a medical disorder, and treatment has been oriented from an audiological perspective. Studies and neurophysiology has shown tinnitus to be a transdiagnostic disorder, which mean th...
Broholm, Rikke; Just, Sven; Jørgensen, Maja; Bækgaard, Niels
Treatment of acute iliofemoral deep venous thrombosis (DVT) with catheter-directed thrombolysis (CDT) has been performed in Denmark since 1999. The purpose of CDT is to dissolve thrombus and to restore the venous lumen as fast as possible and thereby save venous valve function and prevent...... postthrombotic syndrome. Danish studies have shown that treatment of acute iliofemoral DVT using CDT results in good patency, preserves venous valve function, reduces the frequency of PTS, and is associated with a higher quality of life....
Junker, Anders; Kaltoft, Anne; Hassager, Christian; Christensen, Erika; Lippert, Freddy; Ravn, Hanne Berg; Eiskjær, Hans; Tilsted, Hans-Henrik; Schmidt, Henrik; De Haas, Inge; Møller, Jacob Eifer; Ravkilde, Jan; Lassen, Jens Flensted; Wachtell, Kristian; Holmvang, Lene; Jensen, Lisette Okkels; Greve, Matias Lindholm; Engstrøm, Thomas
Despite rapid revascularisation with circulatory support using inotropes and intra-aortic balloon counterpulsation, the mortality of cardiogenic shock complicating acute myocardial infarction still exceeds 50%. An alternative treatment strategy is restoration of cardiac output by using a ventricu...
Tumour necrosis factor antagonists (anti-TNFα) have become an invaluable treatment against chronic inflammatory diseases. Individuals treated with anti-TNFα have more than a fourfold increased risk of tuberculosis (TB) reactivation depending on the clinical setting and the TNF-antagonist used. All...... candidates for anti-TNFα treatment in Denmark should be evaluated for possible latent TB using history of exposure, chest X-ray and an interferon-γ release assay. Preventive chemotherapy is recommended for all individuals with latent TB infection before initiation of anti-TNFα as it is expected to reduce the...
Burgdorf, Stefan K; Qvist, Niels; Gögenur, Ismail
Short bowel syndrome is the result of extensive surgical resection, inherited defects or loss of functional absorbing intestine. Parenteral nutrition is associated with high economical expenses, increased morbidity and decreased quality of life. Intestinal transplantation is associated with high...... morbidity and mortality rates. Segmental reversal of the small bowel can prolong the transit time in the small bowel and in many cases permanently end parenteral nutrition dependency. Segmental reversal of the small bowel should be integrated in the surgical treatment of adults with short bowel syndrome....
Background and purpose: Today's political guidelines show increased investment in mental health care. Many people with mental illness, who have lost their employability, report that they feel they have not been treated for their mental health problem. As a nurse working with the patient with a diagnosis of paranoid schizophrenia , one is mostly dependent on using oneself as an instrument. It is therefore important to be aware of one's own skills, and the ways in which competence will affect t...
Janum, Susanne; Kristensen, Billy Bjarne
The use of NSAIDs for postoperative pain management following orthopaedic surgery or during conservative treatment of fractures is controversial. Experimental animal models suggest NSAIDs inhibit bone healing. In a review of the literature, there was no clinical evidence to support categorical...... discard of NSAID for postoperative pain relief in uncomplicated cases. However, NSAID should be considered a potentiel risk factor of impaired bone healing and avoided in patients with a high risk of pseudoarthrosis. Recommended daily doses should be respected and duration of treatment should be limited....
Lauridsen, Mette Høj; Boesgaard, Trine Welløv; Pedersen, Oluf Borbye; Hansen, Torben; Hertz, Birgitte
A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an...... activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months...
Lauridsen, Mette Høj; Boesgaard, Trine Welløv; Pedersen, Oluf; Hansen, Torben; Hertz, Birgitte
A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an...... activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months...
Andersen, Ase Bengård; Lillebæk, Troels; Bang, Didi; Prahl, Julie
and oxazolidinones are also being assessed in human phase II and III trials. Efforts are made to develop easy-to-handle diagnostic tools that will allow early detection of potential MDR or XDR cases. The Xpert RIF/MTB is a prototype of such an invention. At long last the field is moving slowly forward....
Biswas, Sugata Narayan; Chakraborty, Partha Pratim; Gantait, Kripasindhu; Bar, Chittaranjan
A 52-year-old man presented with high-grade fever, headache and painful vesicular skin rash involving the upper trunk and upper extremities, 8 days after initiation of chemotherapy with azathioprine (50 mg/day), which had been prescribed for acral vitiligo. There was neither any history of preceding respiratory or gastrointestinal tract infection, nor was the patient known to have malignancy, drug hypersensitivity, inflammatory bowel disease, vasculitis or other autoimmune disease. Laboratory results revealed leucocytosis with neutrophilia and markedly elevated acute phase reactants. Antinuclear antibody, perinuclear and cytoplasmic antineutrophil cytoplasmic antibody were found negative. Punch biopsy from skin of the upper trunk revealed dense neutrophilic infiltration of dermis without signs of vasculitis, suggestive of Sweet's syndrome. In view of the temporal association with azathioprine and absence of an obvious alternative aetiology, provisional diagnosis of drug-induced bullous Sweet's syndrome was made. Azathioprine was discontinued and high-dose oral prednisolone initiated. The response was dramatic with resolution of skin lesions within 72 h without further recurrence at fourth week of follow-up. PMID:27090551
Preethi GK Venkatesh
Full Text Available Context Azathioprine induced pancreatitis usually runs a benign self limited course with rapid disappearance of signs and symptoms upon with drawl of the drug. Azathioprine is used in treating relapses in patients with autoimmune pancreatitis and maintenance of remission in autoimmune hepatitis. Acute pancreatitis complicated by symptomatic pseudocysts requiring drainage is not usually associated with drug induced pancreatitis. The risk of azathioprine use in patients with underlying disease of pancreas including autoimmune pancreatitis is unclear. Case report We report here a case of an African American patient with co-existing autoimmune pancreatitis and autoimmune hepatitis who developed azathioprine induced acute pancreatitis complicated by a large symptomatic pseudocyst compressing the duodenum requiring a cystoduodenostomy. Conclusions Future studies to investigate the risk of azathioprine induced pancreatitis in the presence of underlying disease of the pancreas including autoimmune pancreatitis are required to further understand the safety of azathioprine in this sub group of patients.
Van Os, E C; Zins, B J; Sandborn, W J; Mays, D C; Tremaine, W J; Mahoney, D W; Zinsmeister, A R; Lipsky, J J
BACKGROUND: 6-Mercaptopurine and its prodrug azathioprine are effective medications for refractory inflammatory bowel disease. However, use of these drugs has been limited by concerns about their toxicity. Colonic delivery of azathioprine may reduce its systemic bioavailability and limit toxicity. AIM: To determine the bioavailability of 6-mercaptopurine after administration of azathioprine via three colonic delivery formulations. METHODS: Twenty four healthy human subjects each received 50 m...
Kellet, Cristian Vera; Navarrete, Romina Andino; Bombardieri, Sergio González; Manriquez, Juan
We report the case of a 42-year-old female with a 5-year history of rheumatoid arthritis treated with Rituximab and Azathioprine. Three months after the initiation of Azathioprine, the patient started with dry cough and noted the rapid development of multiple subcutaneous nodules on her right leg. CT scan of the chest demonstrates pulmonary nodulosis. Skin biopsy was compatible with rheumatoid nodule. A diagnosis of "accelerated cutaneous and pulmonary nodulosis" was considered. Azathioprine ...
Preethi GK Venkatesh; Udayakumar Navaneethan
Context Azathioprine induced pancreatitis usually runs a benign self limited course with rapid disappearance of signs and symptoms upon with drawl of the drug. Azathioprine is used in treating relapses in patients with autoimmune pancreatitis and maintenance of remission in autoimmune hepatitis. Acute pancreatitis complicated by symptomatic pseudocysts requiring drainage is not usually associated with drug induced pancreatitis. The risk of azathioprine use in patients with underlying disease ...
Rae, William; Burke, Georgina; Pinto, Ashwin
Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterised by fatigable voluntary skeletal muscle weakness. The underlying pathogenesis is complex involving adaptive autoimmune responses. Azathioprine remains a first line broad acting immunosuppressant for MG. Due to varied clinical responses to azathioprine we aimed to investigate the relationship between azathioprine metabolites and symptom control. Mild correlations between Quantitative Myasthenia Gravis Score (QMG) vs. 6-thioguanine nucleotides (R=-0.317 p=0.186) and QMG vs. lymphocyte count (R=0.402 p=0.08) were found. Azathioprine metabolite measurement should be considered in MG patients with; pancytopenia, deranged liver function or recurrent infections. PMID:27049566
Szawlowski, P W; Al-Safi, S A; Dooley, T.; Maddocks, J L
The mixed lymphocyte reaction of Lesch-Nyhan patients (HGPRT deficient) was used to study the immunosuppressive effects of azathioprine and 6-mercaptopurine (6-MP). Mitogen stimulated lymphocytes of these patients are highly resistant to azathioprine and 6-MP. When both stimulator and responder lymphocytes in the MLR were HGPRT deficient, azathioprine (36 microM) was much more inhibitory than 6-MP (100 microM). Azathioprine produced inhibition of 98.2% and 78.5% compared with the values of 63...
Hansen, Ellen Kathrine; Olesen, Gitte Gylling Hammershøj; Mullins, Michael
Artiklen sætter fokus på mulighederne for at høste energi direkte fra solen ved brug af intelligente vinduer. Design og udvikling af intelligente teknologier integreret i vinduets design skaber unikke udfordringer og muligheder for at designe bygninger med de bedst mulige omgivelser for mennesker og natur. Gennem en tværfaglig tilgang behandles samspillet mellem dagslys defineret i tekniske termer og dagslys er defineret i æstetiske, arkitektoniske udtryk. Gennem feltstudier af et dansk CO2 n...
Lien, Marie Renée; Torstensen, Renate
Bakgrunn: Akutt ST-elevasjons infarkt er en livstruende tilstand som krever rask behandling. Mange forskningsmiljøer har jobbet med problemstillingen trombolyse eller PCI som revaskulariseringsstrategi. Akutt PCI er under like tidsforhold å foretrekke fremfor trombolyse. Nord-Norges geografi medfører at en stor del av infarktpasientene ikke vil nå invasivt senter innen tidsvinduet for primær PCI. Vi ønsket derfor å analysere tidsforsinkelser i ulike deler av kjeden, og se på hvordan problemst...
Anne Marit Bygdnes
Full Text Available Bakgrunn: Stadig flere personer med utviklingshemning oppnår høg alder. Endring i adaptiv atferd kan være et tidlig tegn på aldersrelaterte lideleser som Alzheimers sykdom. Studien belyser om screeningsinstrumentet ABDQ kan benyttes av omsorgspersoner for å avdekke endring i adaptiv atferd.Materiale og metode: Undersøkelsen omfatter 87 personer med utviklingshemning som tidligere har bodd på en sentralinstitusjon. Datainnsamling skjedde ved at omsorgspersoner fylte ut ABDQ. Resultater: Det var 24 % i utvalget som hadde nedgang i adaptiv atferd. Fortolkning: ABDQ er et hjelpemiddel til å avdekke nedgang i adaptiv atferd. Det er viktig at svikt avdekkes tidligst mulig og videreformidles til helsepersonell for utredning, diagnostisering, relevant behandling og tilrettelagte helse- og omsorgstjenester. Mange personer med utviklingshemning mestrer ikke å informere om egen helsetilstand og er avhengig av at omsorgspersonalet kan avdekke sykdom og lidelser så tidlig som mulig i sykdomsforløpet.
Pasternak, Björn; Svanström, Henrik; Schmiegelow, Kjeld;
%) used azathioprine) in Denmark from 1997 to 2008. We linked registry data on filled drug prescriptions, cancer diagnoses, and covariates and compared rates of overall incident cancer and cancer subgroups between users and nonusers of azathioprine, adjusting for propensity scores. During a median 7...
Baker, L R; Tucker, B; Macdougall, I C; Oommen, R
Four patients with idiopathic membranous glomerulonephritis, heavy proteinuria and progressive renal failure received azathioprine and prednisolone. Renal function improved in all four and proteinuria declined sharply in three. We suggest that treatment with azathioprine and prednisolone may be of benefit in this form of idiopathic membranous glomerulonephritis.
U.S. Department of Health & Human Services — The Medical Product Safety Network (MedSun) is an adverse event reporting program launched in 2002. The primary goal for MedSun is to work collaboratively with the...
Dewey, C W; Coates, J R; Ducoté, J M; Meeks, J C; Fradkin, J M
Five dogs with acquired myasthenia gravis (MG), verified via positive serum acetylcholine (ACh) receptor antibody concentrations, were treated with a drug protocol including azathioprine (AZA). Four of the five dogs were concurrently treated with pyridostigmine. Azathioprine was used as the sole immunosuppressive agent in four dogs. One dog was temporarily treated with a combination of an immunosuppressive dose of prednisone and AZA, then maintained on AZA as the sole immunosuppressive drug. Three patients experienced complete remission of clinical signs within three months of therapy. In the four dogs for which follow-up serum ACh receptor antibody concentrations were available, initial versus final concentrations decreased substantially (81%), coincident with clinical improvement. One dog died suddenly due to a suspected myasthenic crisis before attaining the target dose of AZA. Two of the four surviving dogs were euthanized approximately one and seven years after diagnosis. One of these two dogs was euthanized because of a rib osteosarcoma, and the other dog was euthanized because of paraparesis of undetermined cause. The remaining two dogs were alive and doing well at the time of final follow-up evaluation, approximately six months and one year after diagnosis. The use of AZA as a therapeutic agent for acquired canine MG has not been investigated. The cases presented in this report suggest a potentially important role for AZA in the treatment of acquired MG in dogs. PMID:10493415
Oppgaven tar for seg jenter i grunnskolealder som har vært utsatt for incest, og bruken av kognitiv behavioristiske behandlingsmetoder. Jeg ønsket å se på mulighetene for å benytte denne behandlingsmetoden i arbeidet med incestofre for å dempe deres skyldfølelse og øke deres sosiale kompetanse. Problemstillingen er formulert som følger; ”I hvilken grad og på hvilken måte kan kognitiv behavioristiske behandlingsmetoder, med vekt på selvinstruksjoner, benyttes i behandling av jenter i ...
Nielsen, Kurt Gammelgaard
SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende.......SDUs erfaringer med projektet Port 22: en virtuel platform med Open Office som kontorpakke til studerende....
Chocair, P; Duley, J; Simmonds, H A; Cameron, J S; Ianhez, L; Arap, S; Sabbaga, E
Early rejection can still complicate renal transplantation even with cyclosporin. We added low-dose allopurinol (25 mg on alternative days) to "triple" immunosuppression with cyclosporin, prednisolone, and azathioprine for twelve recipients of cadaver renal grafts. The controls were fifteen patients on triple therapy alone. Only one rejection episode occurred among the allopurinol-treated patients, whereas eleven controls had rejections (seven with more than one episode). Allopurinol may be toxic when combined with azathioprine, yet the bone marrow tolerated the new regimen well. As expected, reduction of the azathioprine dose was necessary in the treated group. PMID:8100914
Full Text Available Two patients having air-borne contact dermatitis (ABCD caused by Parthenium hysterophorus.for 10 and 15 years respectively and without having had complete remissions in spite of oral betamethasone in a dose of 2-3 mg per day, experienced complete relief while taking 50-100 mg azathioprine for 5 and 12 weeks without having to take systemic corticosteroids. There were no side effects of azathioprine. With further experience and standardization of the treatment schedule, it may be possible to use azathioprine as a corticosteroid-sparing agent to reduce the side effects of corticosteroids in patients having ABCD.
Sommeren 2016 vil blive husket for den omsiggribende dille, Pokémon Go, med over 100 millioner downloads. Tusindvis af især børn og unge, men også forældre med barnevogne og hele familier, kunne pludselig ses på gader og stræder, i parker og grønne områder med en smartphone i hånden på jagt efter...
. Muligheder i software optimering blev studeret i relation til optimal billedkvalitet og kontrol optagelser, for at undersøge om det var muligt at acceptere diagnostisk billedkvalitet og derved tage afsæt i ALARA. Metode og materialer Et kvantitativt eksperimentelt studie baseret på forsøg med teknisk og...... humant fantom. CD Rad fantom anvendes som teknisk fantom, hvor billederne blev analyseret med CD Rad software, og resultatet var en objektiv IQF værdi. Det humane fantom var et lamme pelvis med femur, der via NRPB’ er sammenlignelig med absorptionen ved et femårigt barn. De humane forsøgsbilleder blev...
Englund, Linn; Gunnarsson, Kristin
Bakgrund Kraven på evidensbaserad vård ökar ständigt. Att jämföra patienters självskattade besvär före och efter behandling är ett sätt att utvärdera behandlingseffekten. Rösthandikappindex (RHI) och VA-skala för röstbesvär är två verktyg för utvärdering av röstbehandling. Tidigare studier har visat att röstbehandling ger minskade självskattade röstbesvär. Syfte Syftet med denna studie var att med självskattningsformulär utvärdera effekten av logopedisk röstbehandling i Västerbottens läns la...
Münch, A; Fernandez-Banares, F; Munck, L K
BACKGROUND: Microscopic colitis (MC) is a common chronic diarrhoeal disease, and remission can be induced with budesonide. However, diarrhoea relapses frequently when budesonide is tapered and a few patients become budesonide intolerant. AIM: To examine retrospectively the effect of azathioprine...
SAMMENDRAGNye indikasjoner for behandling av hyperbilirubinemi hos nyfødte (bilirubinskjema fra Hillingdon sykehus,England) ble innført ved Vestfold sentralsykehus primo 1994. Endringene i panoramaet av behandlingstiltak(lysbehandling, utskiftningstransfusjon) ble registrert i kohortene av levende fødte ved sykehuset i toårsperioden1994-95 og sammenlignet med foregående treårsperiode 1991-93. Total lysbehandlingsprevalens falt signifikantfra 6,9% av levende fødte i perioden 1991-93 til 5,5% ...
Neeraj Dhaun; Catherine Hanna; Maria Squires; Simon Watson
Gout is a common problem in renal transplant recipients but often difficult to treat. Allopurinol can be combined with azathioprine but clinicians should be aware of the need for dose reduction, the potential to measure azathioprine breakdown products and the possible side effects of this combination. Leucopenia is a known side effect but this case report shows that haemolytic anaemia can also occur. [Int J Basic Clin Pharmacol 2013; 2(3.000): 330-332
Full Text Available Gout is a common problem in renal transplant recipients but often difficult to treat. Allopurinol can be combined with azathioprine but clinicians should be aware of the need for dose reduction, the potential to measure azathioprine breakdown products and the possible side effects of this combination. Leucopenia is a known side effect but this case report shows that haemolytic anaemia can also occur. [Int J Basic Clin Pharmacol 2013; 2(3.000: 330-332
Goddard, C. J.; August, P. J.; Whorwell, P J
A patient with Crohn's disease and alopecia totalis is described. Despite relative inactivity of the Crohn's disease, treatment with azathioprine was commenced. This led to complete regrowth of hair which was lost when the drug was discontinued. Re-institution of azathioprine restored hair to normal again and the patient has since declined to try stopping the drug despite the knowledge of potential side effects.
M. Silva; Hazleman, B L
Several studies have demonstrated the beneficial effect of azathioprine in rheumatoid arthritis. But fears have been expressed about the possible mutagenic and teratogenic effects of prolonged use. If the drug could be withdrawn once remission is achieved, and this remission be then maintained with other agents, the possible complications of long-term therapy might be avoided. A double-blind controlled study was carried out over 8 months in 32 patients receiving long-term azathioprine therap...
Neurath, M; Wanitschke, R; Peters, M.; Krummenauer, F; zum, B; Schlaak, J.
BACKGROUND—Crohn's disease is a chronic inflammatory disease of the alimentary tract. Azathioprine is an effective agent in the management of chronic active Crohn's disease leading to long term remission of disease activity. Such treatment leads to limited efficacy or side effects in a small subset of patients. AIMS—To compare efficacy and side effects of treatment with azathioprine plus corticosteroids versus mycophenolate mofetil (MMF) plus corticosteroids in patients wit...
Rinkardt, N E; Kruth, S.A.; A Kaushik
This study investigates serum immunoglobulin (SIg) levels and lymphocyte subpopulations in normal dogs in response to putative immunosuppressive doses of prednisone and/or azathioprine. The objectives were to quantify SIg levels and lymphocyte subpopulations, including Thy-1+, CD4+, CD8+ and B cells, in normal dogs both before and after the administration of prednisone and/or azathioprine at 2 mg/kg, PO, each. Eighteen beagles were divided into 3 groups of 6 dogs each. Blood samples for radia...
Weersma, Rinse K; Manou R Batstra; Kleibeuker, Jan H; van Dullemen, Hendrik M.
Context Azathioprine is frequently used in the treatment of Crohn’s disease. A severe side effect is acute pancreatitis, which is specific for Crohn’s disease. Autoantibodies against exocrine pancreas occur in about 30% of Crohn’s disease cases but not in other inflammatory diseases. Pancreatic autoantibody positive Crohn’s disease patients might have a low grade inflammation of the pancreas which may be aggravated by the introduction of azathioprine, resulting in clinically overt acute pancr...
Jain, Pritam S.; Pradip Thakre; Chaudhari, Amar J.; Chavhan, Manish L.; Surana, Sanjay J.
Introduction: An HPTLC method for analysis of Azathioprine in bulk and pharmaceutical formulation has been established and validated. Materials and Methods: The analyte was separated on aluminium plates precoated with silica gel 60 F254. The mobile phase was Ethyl acetate: Methanol: Triethylamine (4:1:0.5v/v). Quantification was done by densitometric scanning at 300nm. Results: Response was a linear function of Azathioprine concentration in the range of 200-1200 ng/band. The limit of detectio...
Rinkardt, N E; Kruth, S A; Kaushik, A
This study investigates serum immunoglobulin (SIg) levels and lymphocyte subpopulations in normal dogs in response to putative immunosuppressive doses of prednisone and/or azathioprine. The objectives were to quantify SIg levels and lymphocyte subpopulations, including Thy-1+, CD4+, CD8+ and B cells, in normal dogs both before and after the administration of prednisone and/or azathioprine at 2 mg/kg, PO, each. Eighteen beagles were divided into 3 groups of 6 dogs each. Blood samples for radial immunodiffusion assay of IgG, IgM and IgA, complete blood count (CBC)and flow cytometry were collected prior to the administration of any drugs and again after 14 d of azathioprine, prednisone or azathioprine and prednisone. Peripheral blood mononuclear cells were isolated using density centrifugation and were incubated with monoclonal antibodies reacting with CD4+, CD8+, Thy-1+ and membrane immunoglobulin. Lymphocyte subsets were quantified using flow cytometry. Azathioprine-treated dogs had no significant changes in SIg levels or lymphocyte subpopulations. Prednisone-treated dogs had significant (P azathioprine-treated dogs had significant (P dogs also had a significant decrease in erythrocyte number and a significant increase in the monocyte count. These findings suggest that azathioprine and prednisone in combination or prednisone alone may be useful for the treatment of T cell-mediated diseases since decreased circulating T cell levels were demonstrated following treatment. The combination of drugs or azathioprine alone may not be appropriate for treatment of acute or autoantibody-mediated immune disease, because SIg levels were minimally affected by treatment. PMID:9918329
Jürgen Habermas: "Der philosophische Diskurs der Moderne" - Æstetikken som krisesymptom, opgør med den fornuftskritiske tradition.......Jürgen Habermas: "Der philosophische Diskurs der Moderne" - Æstetikken som krisesymptom, opgør med den fornuftskritiske tradition....
Pedersen, Michael Svendsen
Med udgangspunkt i et konkret undervisningsforløb, "Forberedelse til SOSU", hvor kvinder med anden etnisk baggrund end dansk forberedes til at tage en SOSU-uddannelse gennem en kombination af praktik og sprogundervisning, undersøges forskellige læringsdimensioner - kognitiv sprogtilegnelse...
Sørensen, Bo Wagner; Madsen, Diana Højlund
Rapporten er baseret på gruppeinterview med 33 unge med etnisk minoritetsbaggrund. De unge er blevet spurgt om uddannelses- og erhvervsønsker og berører en række emner som familie, ligestilling, diskrimination og integration....
SAMMANFATTNING Bakgrund: Vid behandling av ätstörningar hos barn och ungdomar konstateras att föräldrars delaktighet har en betydande roll. Sjuksköterskan kan möta föräldrar till barn och ungdomar med ätstörning inom olika vårdinstanser och vårdformer och för att kunna ge stöd och god omvårdnad med familjen i fokus, är det av intresse att belysa upplevelser och erfarenheter hos föräldrar, av att leva med och/eller vårda barn/ungdom med ätstörning. Syfte: Att beskriva föräldrars upplevelser o...
Makhyoun, Mohamed A.; Massoud, Raghdaa A.; Soliman, Saied M.
The molecular structure and the relative stabilities of the four possible tautomers of the immunosuppressant azathioprine (AZA) are calculated by DFT/B3LYP method using different basis sets. The results of the energy analysis and thermodynamic treatment of the obtained data are used to predict the relative stabilities of the AZA tautomers. The effect of solvents such as DMSO and water on the stability of the AZA tautomers was studied using the polarized continuum method (PCM) at the same level of theory. The calculation predicted that, the total energies of all tautomers are decreased indicating that all tautomers are more or less stabilized by the solvent effect. The vibrational spectra of AZA are calculated using the same level of theory and the results are compared with the experimentally measured FTIR spectra. Good correlation is obtained between the experimental and calculated vibrational frequencies (R2 = 0.997). The electronic spectra of AZA in gas phase and in methanol as solvent are calculated using the TD-DFT method. The calculations predicted bathochromic shift in all the spectral bands in presence of solvent compared to the gas phase. Also the NMR spectra of all tautomers are calculated and the results are correlated with the experimental NMR chemical shifts where the most stable tautomer gives the best correlation coefficient (R2 = 0.996).
Hala M T El-Mougy*, Gehan A Youssef
Full Text Available Background: Rosemary is widely found along the coasts of the Mediterranean Sea. Its leaves or extract were found to have a high antioxidant and anti-inflammatory activity. It is also used as an antispasmodic, analgesic, anti-rheumatic and expectorant. These actions are mainly due to its content of essential oils. Azathioprine (AZA is an immunosuppressive drug. It is widely used in many diseases. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Aim of the work: This work was done to study the effect of dietary supplement of rosemary leaves as a strategy for amelioration of the side-effects of azathioprine. Material and Methods: Thirty-two adult male albino rats were used in this study. They were equally divided into four groups. Group I: control group, group II: rosemary group, the animals were given a daily oral dose of rosemary leaves extract. Group III: azathioprine group, the animals were given a single dose of AZA intraperitoneally. Group IV: rosemary azathioprine group: the rats were given daily doses of rosemary leaves extract then azathioprine in the last day of the experiment as in the previous regimen. The experiment continued for ten days. Blood samples were taken from all groups and examined for tumour necrosis factor alpha, serum amylase enzyme, C-reactive protein and renal function tests (serum urea and creatinine. Results: Rosemary significantly decreased the levels of tumour necrosis factor alpha, serum amylase enzyme and serum urea and C-reactive protein in rosemary AZA group compared to AZA group . Conclusion: The aqueous rosemary leaves extract has the ability to ameliorate the biochemical pathways of the side-effects of azathioprine, so it is advisable to give it concomitantly to patients treated by azathioprine.
Rodriguez, Damon B; Mackin, Andrew; Easley, Roger; Boyle, Carolyn R; Hou, Weiying; Langston, Cory; Walsh, Amy M; Province, Michael A; McLeod, Howard L
Thiopurine methyltransferase (TPMT) produces inactive metabolites of azathioprine and, in humans, has a variable amount of activity. Humans with low TPMT activity commonly develop myelotoxicity when receiving azathioprine. Our study sought to characterize the distribution of TPMT activity in a population of dogs and to determine whether the pretreatment knowledge of red blood cell (RBC) TPMT activity could predict myelotoxicity in dogs receiving azathioprine. RBC TPMT activity was measured in 299 healthy dogs, and 9 dogs that represented a wide range of enzyme activity received azathioprine at a standard therapeutic dose for 30 days. TPMT activity in healthy dogs was log normally distributed and varied over an approximately 7-fold range. Geometric mean, minimum, and maximum RBC TPMT activities were 37.1, 16.3, and 115 nmol per gram of hemoglobin (gHb) per hour, respectively. TPMT deficiency was not identified. Two populations of TPMT activity in dogs were detected by statistical modeling (commingling analysis). Dogs with intermediate TPMT activity (14-38 nmol/gHb/h) receiving azathioprine had significantly lower neutrophil counts during week 4 than during weeks 0-3, whereas those with high activity (>39 nmol/gHb/h) did not have a significant change in neutrophil count. An analysis of TPMT activity in 6 dogs with a history of azathioprine-associated myelotoxicity in a clinical setting revealed either intermediate or high TPMT enzyme activity in all dogs, suggesting that TPMT activity, as measured in RBCs, is not the sole cause of severe azathioprine-associated myelosuppression in dogs. PMID:15188821
U.S. Department of Health & Human Services — The DailyMed RESTful API is a web service for accessing current SPL information. It is implemented using HTTP and can be thought of as a collection of resources,...
U.S. Department of Health & Human Services — PubMed comprises more than 26 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to...
U.S. Department of Health & Human Services — DailyMed provides high quality information about marketed drugs. This information includes FDA labels (package inserts). This Web site provides health information...
Munk, Mette; Bertelsen, Katrine
Bogen henvender sig primært til det pædagogiske personale med målgruppen daginstitutioner. Bogen skal stimulere arbejdet med at gøre bevægelse til en integreret del af kulturen i daginstitutioner - at få det pædagogiske personale til - at sætte ord på og spørgsmålstegn ved deres pædagogiske bevæg...
Cummins, D; Sekar, M; Halil, O; Banner, N
It is widely recommended that, during concurrent therapy with allopurinol, the azathioprine dosage should be decreased by at least two thirds. We retrospectively studied compliance with this guideline in 24 patients who had commenced allopurinol at a median of 33 months (range, 2-145 months) after heart and/or lung transplantation. The median reduction in azathioprine dose at initiation of allopurinol was 73.3% but ranged from 0% to 90% (>67% in 14 patients). Within 3 months, 11 (46%) of the patients became leukopenic (white blood cell count azathioprine by two thirds or greater reduced but did not abolish the risk of myelotoxicity. These data highlight the need for close hematological monitoring of patients treated with this drug combination. Agents other than allopurinol should be considered for treating hyperuricemia after thoracic organ transplantation. PMID:8669118
V diplomskem delu predstavljamo problematiko samomorilnosti med mladimi. Opisali smo samomorilnost skozi zgodovino, statistične podatke o samomoru v Sloveniji in v Celjski regiji. V Sloveniji predstavlja samomorilnost velik problem, saj imamo izredno visok samomorilni količnik, v primerjavi z drugimi državami sveta, prisoten že več desetletij. Še zlasti pa je velika samomorilna problematika med mladimi, kjer statistični podatki beležijo porast samomorov v populaciji adolescentov. Z namenom, d...
Al-Safi, S A; Maddocks, J L
6-MP inhibitory effects on the MLR were reversed by AIC (46%), adenine (32%), hypoxanthine (89%), adenosine (86%) and inosine (93%). AIC, adenine, hypoxanthine and inosine had no effect on azathioprine inhibition of the MLR. Adenosine at 10 microM caused 29% reversal and had no effect at 100-400 microM on azathioprine inhibition of the MLR. Reversal of 6-MP suppression of the MLR was decreased with the delay of adenosine addition. Guanine, xanthine and guanosine caused no reversal of 6-MP or ...
Stolzenburg, Tilo; Ljungmann, Ken; Christensen, Henrik
healing was tested. METHODS: In an experimental study, rats were randomly given one oral dose of azathioprine (5 mg or 20 mg/kg body weight per day) or placebo. After 28 days of treatment, a left colonic anastomosis was performed. After three days of healing, the breaking strengths of the anastomoses were...... tested, along with measurements of azathioprine major metabolite concentrations: 6-thioguanine and 6-methyl-mercaptopurine. RESULTS: There were no significant differences in the anastomotic breaking strength between the three groups. CONCLUSIONS: Daily treatment for four weeks with high or low...
Kaballo, Babikir G; Ahmed, Ahmed Elias; Nur, Musa Mohammed; Khalid, Ismail Osman; Abu-Aisha, Hasan
To compare the efficacy of mycophenolate mofetil (MMF) with that of azathioprine (AZA) drugs in the maintenance therapy of lupus nephritis (LN) patients, we studied 81 Sudanese patients with LN (32 in Class III, 34 in Class IV, and 15 in combined Class V + IV of the ISN/RPS 2003 Classification). All patients received induction therapy consisting of monthly intravenous pulse doses of cyclophosphamide (CYC) (500 mg/m 2 of body-surface area) for six months, plus three consecutive pulses of intravenous methylprednisolone 15 mg/kg/day of body weight (maximum 500 mg). Subsequently, 41 (50.6%) patients were randomized into a group that received oral MMF (22 mg/kg/day), and 40 (49.4%) patients randomized to a group that received oral AZA (2 mg/kg/day). All patients initially received oral prednisone (1 mg/kg of body weight daily) for four weeks. The baseline characteristics of the two groups were similar. Total remission rate was 75.3% (80.5% in MMF and 70% in AZA), complete remission rate of 54.3% (56.1% with MMF and 52.5% with AZA), and a partial remission rate of 21% (24.4% with MMF and 17.5% with AZA) over 29 months. During maintenance therapy, six patients died (four in the AZA group and two in the MMF group), and end-stage renal disease (ESRD) developed in five patients (three in the AZA group and two in the MMF group). During the 36-months of the study, both groups had comparable event-free survival rate for the composite end point of death or ESRD and rate of relapse-free survival. Furthermore, both groups had no significant differences in terms of frequency of hospitalization, amenorrhea, infection, nausea, and vomiting. We conclude that our study showed that short-term therapy with intravenous CYC followed by maintenance therapy with oral MMF or AZA had similar efficacy and safety for the treatment of patients with moderate to severe LN. PMID:27424688
Grensen mellom legitime markedsstrategier og markedsmanipulasjon ved HFT-handel: Om HFT-handel, ved bruk av enkelte markedsstrategier, kan være i strid med forbudet mot markedsmanipulasjon, og en komparativ fremstilling av nåværende og fremtidige plikter knyttet til bruken av HFT-handel.
Solbakken, Tone Jørgensen
Oppgaven behandler og besvarer to problemstillinger. Den første problemstillingen er om man ved bruk av HFT som handelsmetode i visse typetilfeller kan rammes av forbudet mot markedsmanipulasjon i vphl. §3-8. Videre vil gjeldende informasjonsplikter som er nært knyttet til forbudet mot markedsmanipulasjon bli behandlet og sammelignet med nye reguleringsinitiativ for verdipapirmarkedene som er ment å regulere og adressere utfordringene ved HFT-handel. Den andre problemstillingen er om det økte...
Nielsen, Inger Marie
To teoretiske sværvægtere bliver koblet sammen i Inger Marie Larsen-Nielsen arbejdspapir om professionalisme med innovativt potentiale. De to teoretikere er læringsteoretikeren John Dewey og socialpsykologen Georg Herbert Mead, som er sat sammen i en teoretisk forståelsesramme omkring professionel...
Bergmann, Troels Korshøj; Mirza, Mansoor Raza; Andersen, Charlotte Brasch;
Formål og baggrund: Paclitaxel (Taxol®) er et kemoterapeutikum der bruges til behandling af bl.a æggestokkræft. Paclitaxel doseres individuelt (175mg/m2) men alligevel er der klinisk betydende variation i forekomsten af bivirkninger (neurotoksicitet, kvalme/opkast, knoglemarvspåvirkning m.......fl). Vores hypotese er at en betydelig del af variationen skyldes genetiske forskelle mellem patienterne. Den hyppigste kilde til genetisk variation er single nukleotide polymorphisms ie SNPs. Vi vil undersøge om SNPs i gener der koder for proteiner der har betydning for transport og omsætning af paclitaxel...... mellem patienterne og fungerer således som dobbeltblindede randomiserede expositioner. Data indsamles prospektivt ved at rekruttere patienter med æggestokkræft der skal have paclitaxel og carboplatin i Odense, Vejle, Herlev, Herning, Lund eller Linköping. Der tages blod fra til genanalyse og plasma til...
Bloch, Sara Brandi; Larsen, Michael
This evaluation of a Cochrane-review including five clinical trials of good methodological quality indicates that the antiangiogenic therapeutic agents, pegaptanib and ranibizumab, are effective treatment strategies for neovascular Age-Related Macular Degeneration (AMD). The review does not inclu...
The aim of this paper was to illuminate the effect of mentalizationbased psychotherapy. The patients in the survey group were interviewed before and after treatment with regard to specific symptoms of borderline personality disorder and symptoms of other personality disorders with the semi structured interviews ZAN-BPD and SCID-II. Open interview questions that were worked up in a qualitative manner were as well put to the patients that had received the treatment program. A focus group interv...
Øvrehus, Kristian Altern; Andersen, Poul Erik; Jacobsen, Ib Abildgaard
angioplasty. A total of 124 patients were treated; 31% were normotensive immediately after angioplasty, 59% had improved blood pressure control and 10% had unchanged hypertension. The corresponding figures after six months and at the latest follow-up were 13, 72 and 15%. Udgivelsesdato: 2008-Jan-21...
Bendtzen, Klaus; Geborek, Pierre; Svenson, Morten;
Remicade/infliximab is effective in rheumatoid arthritis (RA), but response failure is frequent. Sera from 106 RA patients were monitored using an RIA for functional infliximab and an RIA for anti-infliximab antibody (Ab). S-infliximab varied considerably, e.g. 0-22 microg/ml before the 3rd infus...
Juul, Niels; Sollid, Snorre; Sundstrøm, Terje;
Head trauma causes the death of many young persons. The number of fatalities can be reduced through systematic management. Preventing secondary brain injury together with the fastest possible transport to a neurosurgical unit has been shown to be effective in reducing mortality and morbidity. Evi...
Hamberg, Lena; Karlsson, Sanna
Abstract. Several treatment options are described for patients with vocal cord dysfunction. At Karolinska University hospital, these patients are offered treatment by speech and language pathologists. The current study describes traits and treatment effects for 148 people diagnosed with exercise-induced vocal cord dysfunction at Karolinska University hospital who received treatment by speech and language pathologists in 2005-2012. Data were collected from medical records and through a questi...
Rohde, Ulrich; Gylvin, Silas; Vilmann, Peter;
Overweight and obesity are risk factors for several co-morbidities reducing life expectancy. Conservative treatment of obesity is generally ineffective in the long-term. Bariatric surgery has proven effective, but is associated with potential complications. Duodenal-jejunal bypass sleeve is a novel...
Vilsbøll, Tina; Helmsøe-Zinck, Lise; Andersen, A N
Intrauterine insemination with cryopreserved donor semen was performed in 114 women in a total of menstrual 381 cycles during the period 1.2.1991 to 15.5.1993. Eighty-one pregnancies were recorded corresponding to a conception rate of 21% per insemination cycle. After ten cycles the probability of...... conception and expected delivery was respectively 96% and 86%. The results show that intrauterine insemination with donor semen is a good treatment for couples with male infertility. Ultrasonic measurement of the follicles and timing of hCG injection were used for optimal timing of intrauterine donor...... insemination. The quality of the semen used for insemination is important. It is recommended to inseminate with at least two million of spermatozoa where at least 20% have normal motility....
Mannsåker, Ingeborg; Sørensen, Kristine Bjørkaas; Zamfirova, Biliana
The present thesis explores whether mentalization-based psychotherapy (MBT), on theoretical grounds, may be applicable in the treatment of patients with avoidant and paranoid personality disorders. We describe the development of mentalization and the principles of MBT. Characteristics of the two diagnostic groups in question are presented and compared with borderline personality disorder, for which the effectiveness of MBT has been empirically documented. We discuss whether pat...
Ben Salem, Chaker; Salem, Chaker B; Larif, Sofiene; Fathallah, Neila; Slim, Raoudha; Aounallah, Amina; Sakhri, Jaballah; Hmouda, Houssem
Sweet's syndrome has been reported in association with inflammatory diseases such as Crohn's disease. It has also been reported in association with several drugs. Here, we report a rare case of Sweet's syndrome induced by azathioprine in a patient with Crohn's disease. PMID:26219289
Full Text Available SUMMARY. Introduction: Idiopathic pulmonary fibrosis (IPF is characterized by progressive deterioration of lung function, leading ultimately to death. No pharmacological treatment has been found to stabilize the evolution of the disease, but interferon-g and azathioprine have been used as therapeutic options. Aim: To compare the effectiveness of treatment with interferon-g plus low dose prednisone or azathioprine plus low dose prednisone in patients with IPF. Materials and methods: Patients newly diagnosed with IPF were recruited, 22 in total, of whom 10 received azathioprine plus prednisone and 12 patients received interferon-g plus prednisone for six months. Clinical evaluation, lung function tests, HRCT, bronchoscopy and bronchoalveolar lavage (BAL were performed at baseline and after six months of treatment. Results: All patients were alive after six months of treatment. No statistically significant difference between the two groups was detected regarding clinical deterioration, inflammatory biomarkers such as erythrocyte sedimentation rate (ESR, C-reactive protein (CRP, and BAL cell sub-populations. There was a trend, not statistically significant, towards a greater reduction in forced vital capacity and diffusing capacity for carbon monoxide in the interferon-g group. Conclusion: Interferon-g does not offer any therapeutic advantage over azathioprine as regards the clinical course, lung function tests and BAL cell counts of patients with IPF. Pneumon 2009, 22(3:240-253.
Pedersen, E G; Pottegård, Anton; Hallas, J; Friis, S; Hansen, K; Jensen, P E H; Gaist, D
BACKGROUND AND PURPOSE: To evaluate the association between the use of azathioprine and risk of cancer in patients with non-thymoma myasthenia gravis (MG) in a nationwide setting. METHODS: Case-control study based on population-based registries. Cases were patients with MG with a first time...
Al-Safi, S A; Maddocks, J L
Levamisole (1.25-4.15 microM) had no effect on tritiated thymidine incorporation into DNA of mixed lymphocyte cultures. Moreover, it did not cause any reversal of azathioprine (18-36 microM) inhibitory effects on the MLR.
Christoph Elsing; Joerg Placke; Thomas Herrmann
Patients with inflammatory bowel disease have normal life expectancy and, due to modern immunosuppressive therapies, also a normal quality of life. Since mostly young people are affected, their social behaviour suits this environment. Alcohol binging is an increasingly disturbing factor among young people. We describe a patient with Crohn's disease, treated with azathioprine,who developed peliosis hepatis after three epsiodes of alcohol binging. Liver toxicity was not observed previously during the course of the treatment.Azathioprine-induced peliosis hepatis is thought to be idiosyncratic in humans. From animal studies, however,it is clear that hepatic depletion of glutathione leads to azathioprine toxicity to the sinusoidal endothelial cells. Damage of these cells causes peliosis hepatis.Since alcohol binging leads to hepatic glutathione depletion, we conclude that in our patient the episodes of binging have reduced liver gluathione content and therefore this has increased azathioprine toxicity causing peliosis hepatis. The problem of alcohol binging has not yet been addressed in IBD patients undertaking immunosuppressive therapy. This should be reviewed in future considerations regarding patients advice.
Responsiv design är ett begrepp som Ethan Marcotte gjorde känd i sin artikel ”Re-sponsive Web Design” i webbtidningen ”A list apart” år 2010. I dagens läge vet en webbutvecklare sällan i förhand med hurdan apparat människorna besöker sina publikationer med. Det kan vara en smarttelefon, surfplatta, bordsdator eller t.o.m. en televis-ion. Alla dessa apparater kan ha olika skärmstorlekar och funktioner och ställer då också krav på hur en webbutvecklare planerar sin webbplats. Att planera en web...
De fleste af os tænker ikke på engle som kønnede væsner med en seksualitet, og selv om vi er i stand til at acceptere engle i alle mulige afskygninger, fra juletræets tyksakker i glitrende guld til frygtindgydende skikkelser i de bibelske skrifter, så er vi tilbøjelig til at ignorere spørgsmålet ...
Linnerud, Kristin; Oklevik, Ove; Slettvold, Harald
Dette notatet har sitt utspring i forelesninger og undervisning for 3.års studenter i økonomi og administrasjon ved høgskolen i Sogn og Fjordane. Notatet er særlig lagt opp mot undervisningen i SPSS i de to kursene ”OR 685 Marknadsanalyse og merkevarestrategi” og ”BD 616 Økonomistyring og analyse med programvare”.
- og studentereksamen - chancen til at gennemføre drømmen om at kunne beskæftige sig med de temaer, han formulerede som meningsfulde. Det er også en fortælling om at tidsånden, sådan som den organiseres i undervisningssystemerne nu om dage, ikke er en naturlov. At "Bildung" kan foregå på helt andre...
Gonzalez, Daniel; Caerols, Pablo; Olmedo, Juan Carlos [Enorchile (Chile)
The greenhouse gas emissions from the Chilean copper mining industry account for 61% of total and this has been a serious cause for concern. The amount of water used for mining operations is also great and it has to be desalinated. The carbon footprint of desalinated water is large. This paper discusses the desalination of water using multi-effect desalination (MED). The most commonly used technology for desalination is the reverse osmosis process, where pre-treated water is forced through a semi-permeable membrane. The MED technology uses low-pressure steam from turbine or engine exhaust gases, which makes it highly efficient and cost effective. The process is briefly explained and a diagram shows the flow process. Advantages include low electricity consumption, low maintenance, and high reliability. Additionally, no pretreatment of the water is required and the process thus also decreases the carbon footprint. It can be concluded that MED combined with a power plant is a powerful solution for mine operations.
U.S. Department of Health & Human Services — MedPACs Data Book is the result of discussions with congressional staff members regarding ways that MedPAC can better support them. Some of the information it...
Andersen, Aage T.; Feilberg, Michael; Milhøj, Anders
IML i SAS anvendes til matrixberegninger som en integreret del af SAS pakken. Den anvendes typisk til matrixberegninger i tilknytning til andre SAS applikationer, fx kan matricer let dannes ud fra datasæt i SAS. Desuden indeholder IML en række videregående matematiske og statistiske subroutiner......, der ikke findes andre steder i SAS.I bogen gennemgås matrixregning svarende til et indledende matematikkursus ved en højere læreanstalt. Den teoretiske gennemgang understøttes og demonstreres konsekvent med IML programmering, så fokus er på praktiske anvendelser af matricer....
Walsh, M.; Faurschou, M.; Berden, A.;
BACKGROUND AND OBJECTIVES: Treatment with azathioprine within 3 months of remission induction with cyclophosphamide is a common treatment strategy for patients with ANCA-associated vasculitis. This study comprised patients undergoing long-term follow-up who were randomly allocated to azathioprine...... after 3-6 months or after 12 months of cyclophosphamide treatment. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Patients from 39 European centers between 1995 and 1997 with a new diagnosis of ANCA-associated vasculitis that involved the kidneys or another vital organ were eligible. At the time of...... diagnosis, participants were randomly allocated to convert to azathioprine after 3-6 months (the azathioprine group) or after 12 months of cyclophosphamide (the cyclophosphamide group). Patients who did not achieve a remission within 6 months were excluded. This study assessed relapses, ESRD, and death...
Hallborg, Stefanie; Ehrling, Isabell
Studiens syfte var att undersöka kopplingen mellan hur professionella inom socialt arbete arbetar med män som utövat våld i en nära relation och hur de ser på problemet. Som metod användes en kvalitativ intervjustudie med sju yrkesverksamma inom socialt arbete. De informanter som deltog arbetade antingen inom socialtjänsten eller i verksamheter som erbjuder behandling för våldsutövande män. I studien användes ett genusperspektiv och den ekologiska modellen som teoretiska utgångspunkter. Studi...
Roland, S.; Delwaide, Jean; Cornet, G.; Mahieu, Ph; Jacquet, N.; Belaiche, Jacques
We report a case of hepatoportal sclerosis in a renal transplant patient treated with azathioprine. The initial symptom was ascites. On the biochemical level, there were cholestasis without cytolysis or hepatocellular insufficiency. A presinusoidal portal hypertension was found on haemodynamic studies, without portal thrombosis at CT-scan. A diagnosis of hepatoportal sclerosis was evoked on histology and attributed to azathioprine. This case gives an illustration of a classical albeit rare co...
Silman, A.J.; Petrie, J.; Hazleman, B; Evans, S. J.
Two hundred and two patients with rheumatoid arthritis (RA) starting treatment with large doses of azathioprine (median 300 mg/day) between 1964 and 1974 were followed up until March 1984. All but one patient (99.5%) were traced from either hospital or general practice records; and death certificates, where relevant, were obtained. A comparison group of 202 patients with RA not treated with azathioprine was selected from the diagnostic index of another rheumatology unit and followed up in 198...
Löwhagen, G B; Lindstedt, G
Azathioprine, a cytostatic and immunosuppressive drug in use for some 30 years, can give rise to life-threatening neutropenia and thrombocytopenia. This may be caused by unexpectedly high concentrations of cytotoxic metabolites due to abnormally slow inactivation of 6-mercaptopurine (6-MP) by thiopurine S-methyltransferase (TPMT) and/or xanthine oxidase. Low TPMT activity may be due to genetic polymorphism or interaction with drugs such as salicylic acid derivatives, while xanthine oxidase may be inhibited by allopurinol. High TPMT activity, on the other hand, may hamper cytostatic treatment. Safer and more effective treatment with azathioprine and its metabolite 6-MP becomes possible with new laboratory methods for pharmacotherapy monitoring. PMID:10707497
Hala M T El-Mougy*, Gehan A Youssef
Background: Rosemary is widely found along the coasts of the Mediterranean Sea. Its leaves or extract were found to have a high antioxidant and anti-inflammatory activity. It is also used as an antispasmodic, analgesic, anti-rheumatic and expectorant. These actions are mainly due to its content of essential oils. Azathioprine (AZA) is an immunosuppressive drug. It is widely used in many diseases. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Aim of the wor...
Eva Kwok; Chan, Charles K.
The case of a man who presented with dyspnea and a dry cough six weeks after mediastinal radiotherapy for malignant thymoma is described. The patient was on prednisone (30 mg/day) and azathioprine (100 mg/day) throughout the course of radiation. The respiratory difficulties developed as the dose of prednisone was gradually decreased to 20 mg/day postradiation. Chest x-ray showed bilateral pulmonary infiltrates. Computed tomography scan of the thorax confirmed bilateral ground glass opacities,...
Abdullah Al Maruf; Luke Wan; O’Brien, Peter J
Azathioprine (AZA) is widely used in clinical practice for preventing graft rejection in organ transplantations and various autoimmune and dermatological diseases with documented unpredictable hepatotoxicity. The potential molecular cytotoxic mechanisms of AZA towards isolated rat hepatocytes were investigated in this study using “Accelerated Cytotoxicity Mechanism Screening” techniques. The concentration of AZA required to cause 50% cytotoxicity in 2 hrs at 37°C was found to be 400 μM. A sig...
Bradford, Kara; Shih, David Q
The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine, are efficacious in the arsenal of inflammatory bowel disease (IBD) therapy. Previous reports indicate that 6-thioguanine nucleotide (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with hepatotoxicity and myelotoxicity. Due to their complex metabolism, there is wide individual variation in patient response therein, both in achieving therapeutic drug levels as we...
Stocco, Gabriele; Pelin, Marco; Franca, Raffaella; De Iudicibus, Sara; Cuzzoni, Eva; Favretto, Diego; Martelossi, Stefano; Ventura, Alessandro; Decorti, Giuliana
Azathioprine is a purine antimetabolite drug commonly used to treat inflammatory bowel disease (IBD). In vivo it is active after reaction with reduced glutathione (GSH) and conversion to mercaptopurine. Although this reaction may occur spontaneously, the presence of isoforms M and A of the enzyme glutathione-S-transferase (GST) may increase its speed. Indeed, in pediatric patients with IBD, deletion of GST-M1, which determines reduced enzymatic activity, was recently associated with reduced s...
Ultraviolet irradiation of the nitroimidazole derivatives metronidazole, misonidazole, azathioprine and 1-methyl-4-nitroimidazole in aqueous solution with various reductants produced the respective nitro radical anions, as detected by electron spin resonance spectroscopy. The most effective reductant, yielding high concentrations of the radical anions, was EDTA at pH 10. NADH, NADPH, formaldehyde glutathione and methanol were also tested but were less efficient as reductants. (author)
Moore, D.E.; Chignell, C.F.; Sik, R.H.; Motten, A.G.
Ultraviolet irradiation of the nitroimidazole derivatives metronidazole, misonidazole, azathioprine and 1-methyl-4-nitroimidazole in aqueous solution with various reductants produced the respective nitro radical anions, as detected by electron spin resonance spectroscopy. The most effective reductant, yielding high concentrations of the radical anions, was EDTA at pH 10. NADH, NADPH, formaldehyde glutathione and methanol were also tested but were less efficient as reductants.
Harkin, Kenneth R; Phillips, Dianne; Wilkerson, Melinda
Fourteen dogs with perianal fistulas were entered into a prospective clinical study to investigate the effects of long-term azathioprine on clinical outcome and to determine if the clinical results correlated with lymphocyte blastogenesis tests. Complete remission of perianal fistulas was seen in eight (57%) of 14 dogs; partial remission occurred in one (7%) dog; and no response was detected in five (36%) dogs. The results of lymphocyte blastogenesis assays did not correlate with therapeutic response. PMID:17209081
Holmegaard, Henriette Tolstrup; Malm, Rie Hjørnegaard; Madsen, Lene Møller
Formålet med undersøgelsen er at undersøge de studerendes møde med studiet, deres integration på studiet og de studerendes overvejelser om at blive eller forlade studiet. Undersøgelsen formidler de studerendes perspektiv på første studieår på nanoscience og bidrager med input, der kan bruges...
Denne artikel er første redegørelse for de erfaringer, som er gjort med gruppemusikterapi (GMT) for patienter med borderline-personlighedsforstyrrelse (BPF) i dagbehandlingsregi på Aalborg Psykiatriske Sygehus. Artiklen indeholder både konkrete anvisninger til aktiviteter og interventioner, ligesom...
Jansson, Marie; Sund, Linda
Bakgrund Röstproduktionen är föränderlig och påverkas av miljö och situation. Ofördelaktigt röstbeteende kan leda till röststörningar. Vid behandling av röststörningar är det essentiellt att kartlägga ogynnsamma röstbeteenden. Ljudstudioinspelningar har visat sig otillräckliga vid sådana kartläggningar. Ett verktyg med potential att möjliggöra en mer representativ bild av röstanvändandet är röstackumulatorn VoxLog. Syfte Syftet var att utifrån röstparametrarna SPL och F0 jämföra registreringa...
Hall, Ida; Midestad, Erica
Introduktion: Sjuksköterskor inom somatisk vård möter och vårdar vid ett antal tillfällen per år patienter med diagnosen anorexia nervosa. Anorexia nervosa är en allvarlig sjukdom med hög dödlighet. Diagnosen påverkar både patientens somatiska och psykiatriska status. Patienter med diagnosen anorexia nervosa beskriver ett omvårdnadsbehov ur både ett somatiskt- och psykiatriskt omvårdnadsperspektiv. En framgångsrik allians är viktig för att vård och behandling ska kunna uppnås och upprätthålla...
Denne frembringelse vedrører et høreapparat, der omfatter en identifikationsenhed med en antenne tilpasset til at modtage et aktiveringssignal og til at sende et svarsignal samt med en signalgenerator tilpasset til at genere svarsignalet når aktiveret af aktiveringssignalet, og ligeledes vedrører...
Xenophontos, Eleni; Ioannou, Antreas; Constantinides, Thrasos; Papanicolaou, Eleni
Sweet syndrome (SS) is a rare inflammatory process presenting with painful erythematous skin eruptions, accompanied by fever and neutrophilia. It is associated with upper respiratory infection in fertile women (classic form), malignancy, infections, drugs and autoimmune diseases. Its pathogenesis remains to be determined. Nevertheless, cytokines may have a prominent role, due to a rapid response after corticosteroid administration. We describe a 32-year-old female with autoimmune hepatitis on azathioprine and prednisone, presenting with fever and inflammatory skin eruptions. Histologic examination of the skin lesions showed neutrophilic infiltrations of the dermis, confirming the diagnosis of SS. Concurrently, she tested borderline positive for recent CMV infection. PMID:26913201
Jose Antonio Vargas-Hitos
Full Text Available A 65-year-old woman with bullous pemphigoid presented with fever and several red-purple nodular subcutaneous lesions on both lower legs 1 week after starting treatment with azathioprine (AZA. Biopsy of a skin nodule was compatible with erythema nodosum (EN and hypersensitivity reaction to AZA was suspected. AZA was subsequently discontinued, observing complete remission of fever and EN within 2 weeks. This case highlights the importance of recognizing EN as a possible manifestation of hypersensitivity reaction to AZA.
M. Silva; Hazleman, B L
The ability of azathioprine to reduce the maintenance prednisolone requirement of 31 patients with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA), or both, was tested in a double-blind placebo controlled study over one year. Clinical and laboratory assessments were made at four-weekly intervals over a period of 52 weeks. A statistically significant difference (p less than 0.05) in mean prednisolone dose was noted between the two groups at the end of 52 weeks, there being a fall in...
Full Text Available Various mechanisms contribute to anemia in inflammatory bowel diseases (IBD, drug-related causes being less frequent. The hematological and other adverse events of azathioprine (AZA therapy are well documented, but drug-associated pure red cell aplasia (PRCA is an uncommon event. We hereby describe two cases of AZA-associated PRCA in patients with Crohn′s disease. The diagnosis was supported by pathological reports, and prompt hematological recovery was seen with discontinuation of the offending drug. This report highlights the need to consider this rare entity in IBD patients in appropriate settings and for adopting adequate precautionary measures.
N'Guyen, Y.; Andreoletti, L; Patey, M; Lecoq-Lafon, C.; Cornillet, P; Léon, A.; Jaussaud, R.; Fieschi, C; Strady, C.
We report a case of Epstein-Barr virus (EBV) primo infection with the development of successive infectious mononucleosis, hemophagocytic lymphohistiocytosis, and B-cell lymphoproliferative disorder in a patient treated with azathioprine for Crohn's disease. This case report suggests that specific EBV-related clinical and virological management should be considered when treating a patient with inflammatory bowel disease with azathioprine.
Full Text Available SAMMENDRAGBasert på to intervensjonsforsøk rettet mot helseeffekter i hud og øvre luftveier før og etter inneklimatiltak,drøftes erfaringer med design, metoder og analyse av data. Intervensjonene som ble prøvet ut varantistatisk behandling av dataskjerm (n=117 og storrengjøring i kontormiljø (n=104. Det ble måltstøvkonsentrasjon under vanlig arbeid med direktevisende partikkelteller. Ved støvkonsentrasjoner > 50μg/m 3 hadde tiltakene effekt. Antistatisk behandling av skjermen førte til reduserte hudplager i ansiktet.Kolorimetrisk måling av rødfarge i ansiktet viste ingen forskjeller mellom intervensjon og placebo.Rengjøring av enkeltkontorer førte til reduserte slimhinneplager i øvre luftveier. Personer med tendenstil redusert nesepassasje viste økning av hulmål-parametre, målt med akustisk rhinometri. I beggeforsøk ble endring i helsevariabler før-etter i intervensjonsgruppen sammenlignet med endring ikontrollgruppen. Det konkluderes med at intervensjon som metode i arbeidsmedisinsk forskning erressurskrevende, men har en rekke fordeler som metoden deler med klinisk kontrollerte forsøk.Skyberg K, Skulberg K. Experiences from intervention trials in occupational epidemiology,based on studies of measures to improve indoor air in offices.Nor J Epidemiol ENGLISH SUMMARYBased on two intervention trials on health effects in skin and upper airways, before and after indoor airquality measures, experience with design, methods and data analysis are discussed. Applied interventionswere antistatic treatment of VDU (n=117 and comprehensive cleaning of the office (n=104. Dustconcentrations during usual work were measured, using a particle counter. The interventions showedeffect when the dust concentration was > 50 μg/m 3. Antistatic treatment of the VDU lead to reducedfacial skin symptoms. Colorimetric measurements, however, showed no differences between the interventionand control groups. Cleaning of single offices lead to a
Bradford, Kara; Shih, David Q
The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine, are efficacious in the arsenal of inflammatory bowel disease (IBD) therapy. Previous reports indicate that 6-thioguanine nucleotide (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with hepatotoxicity and myelotoxicity. Due to their complex metabolism, there is wide individual variation in patient response therein, both in achieving therapeutic drug levels as well as in developing adverse reactions. Several strategies to optimize 6-TGN while minimizing 6-MMP levels have been adopted to administer the thiopurine class of drugs to patients who otherwise would not tolerate these drugs due to side-effects. In this report, we will review different approaches to administer the thiopurine medications, including the administration of 6-mercaptopurine in those unsuccessfully treated with azathioprine; co-administration of thiopurine with allopurinol; co-administration of thiopurine with anti-tumor necrosis factor α; 6-TGN administration; desensitization trials; and split dosing of 6-MP. PMID:22072847
Allen, L V; Erickson, M A
The stability of drugs commonly prescribed for use in oral liquid dosage forms but not commercially available as such was studied. Acetazolamide 25 mg/mL, allopurinol 20 mg/mL, azathioprine 50 mg/mL, clonazepam 0.1 mg/mL, and flucytosine 10 mg/mL were prepared in 1:1 mixture of Ora-Sweet and Ora-Plus (Paddock Laboratories), a 1:1 mixture of Ora-Sweet SF and Ora-Plus (Paddock Laboratories), and cherry syrup and placed in polyethylene terephthalate bottles. The sources of the drugs were capsules and tablets. Six bottles were prepared per liquid; three were stored at 5 degrees C and three at 25 degrees C, all in the dark. A sample was removed from each bottle initially and at intervals up to 60 days and analyzed for drug concentration by stability-indicating high-performance liquid chromatography. At least 94% of the initial drug concentration was retained in all the oral liquids for up to 60 days. There were no substantial changes in the appearance or odor of the liquids, or in the pH. Acetazolamide 25 mg/mL, allopurinol 20 mg/mL, azathioprine 50 mg/mL, clonazepam 0.1 mg/mL, and flucytosine 10 mg/mL were stable for up to 60 days at 5 and 25 degrees C in three extemporaneously compounded oral liquids. PMID:8862208
Kara Bradford; David Q Shih
The thiopurine drugs, 6-mercaptopurine (6-MP) and azathioprine, are efficacious in the arsenal of inflammatory bowel disease (IBD) therapy. Previous reports indicate that 6-thioguanine nucleotide (6-TGN) levels correlate with therapeutic efficacy, whereas high 6-methylmercaptopurine (6-MMP) levels are associated with hepatotoxicity and myelotoxicity. Due to their complex metabolism, there is wide individual variation in patient response therein, both in achieving therapeutic drug levels as well as in developing adverse reactions. Several strategies to optimize 6-TGN while minimizing 6-MMP levels have been adopted to administer the thiopurine class of drugs to patients who otherwise would not tolerate these drugs due to side-effects. In this report, we will review different approaches to administer the thiopurine medications, including the administration of 6-mercaptopurine in those unsuccessfully treated with azathioprine; co-administration of thiopurine with allopurinol; co-administration of thiopurine with anti-tumor necrosis factor a; 6-TGN administration; desensitization trials; and split dosing of 6-MP.
Arndal, Lars Stubbe
Tag med digteren Thomas Kingo ud på dybt vand i selskab med lektor og mag.art. Lars Arndal, der kaster nye perspektiver på Kingos forlisdigt Hierte-Suk. Arndal kommer hermed også med et bud på, hvordan man som lærer kan invitere eleverne med på opdagelse i digtet...
Yenson, P.R.; Forrest, D.; Schmiegelow, K.;
risk of hematologic toxicity and leukemogenesis. We present such a patient who was a slow metabolizer for azathioprine, and developed a rapidly lethal form acute myeloid leukemia after relatively low dose exposure to the drug. There was prominent hemophagocytic activity in the bone marrow, and...
Piek, C.J.; Spil, Van W.E.; Junius, G.; Dekker, A.
Background Azathioprine is used as an immunosuppressant in canine immune-mediated hemolytic anemia (IMHA), but this potentially toxic and carcinogenic drug has not been proven to be beneficial. The aim of this study was to determine the difference in outcome and survival of dogs with idiopathic IMHA
Kim, Jung-Hyun; Kim, Ju-Won; Lim, Chae-Young; Park, Hee-Myung
A dog was referred for pancytopenia. Bone marrow biopsy showed hypocellular fatty marrow. Magnetic resonance imaging had a high signal on T1-weighted image in the metaphyseal region of the femur. We suggest that MRI could be a valuable supportive diagnostic method and introduce a strategy of treatment with cyclosporine and azathioprine in canine aplastic pancytopenia.
Kim, Jung-Hyun; Kim, Ju-Won; Lim, Chae-Young; Park, Hee-Myung
A dog was referred for pancytopenia. Bone marrow biopsy showed hypocellular fatty marrow. Magnetic resonance imaging had a high signal on T1-weighted image in the metaphyseal region of the femur. We suggest that MRI could be a valuable supportive diagnostic method and introduce a strategy of treatment with cyclosporine and azathioprine in canine aplastic pancytopenia. PMID:23024391