UK PubMed Central (United Kingdom)

Bovine leukemia virus (BLV), a retrovirus related to human T-cell leukemia virus types 1 and 2, can induce persistent nonneoplastic expansion of the CD5⁺ B-cell population, termed...Full Text Available

UK PubMed Central (United Kingdom)

Age-related alterations in the cellular composition of the B lineage are a major cause of the poor antibody response to vaccination and to infectious agents among the elderly population. The mechanisms...Full Text Available

UK PubMed Central (United Kingdom)

Epigenetic remodeling is a hallmark of cancer, with the frequent acquisition of de novo DNA methylation in CpG islands. However, the functional relevance of de novo...Full Text Available

UK PubMed Central (United Kingdom)

We presented data showing that the CART-19 cells expressing the 4-1BB signaling domain can have unprecedented and massive in-vivo expansion, traffic to tumor sites, persist long term in vivo, and induce...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Cyclooxygenase-2 (COX-2) content is increased in many types of tumor cells. We have investigated the mechanism by which resveratrol, a stilbene that is pro-apoptotic in many tumor cell lines, causes apoptosis in human head and neck squamous cell carcinoma UMSCC-22B cells by a mechanism involving cellular COX-2. UMSCC-22B cells treated with resveratrol for 24 h, with or without selected inhibitors, were examined: (1) for the presence of nuclear activated ERK1/2, p53 and COX-2, (2) for evidence of apoptosis, and (3) by chromatin immunoprecipitation to demonstrate p53 binding to the p21 promoter. Stilbene-induced apoptosis was concentration-dependent, and associated with ERK1/2 activation, serine-15 p53 phosphorylation and nuclear accumulation of these proteins. These effects were blocked by ...

British Library Electronic Table of Contents (United Kingdom)

Recent improvements in cell purification and transplantation techniques have contributed to the identification of cell populations known as tumor-initiating cells (TIC). This discovery has led to the -cancer stem cell hierarchy- concept, which holds that tumors are organized as a hierarchy of malignant tissues sustained by such TIC. However, this concept remains controversial. In this review, we examine recent advances in cancer stem cell research that have been generated from studies of Philadelphia (Ph) chromosome-positive leukemia. The abnormal Ph chromosome, which arises from a translocation creating the BCR-ABL1 fusion gene, is most commonly associated with chronic myelogenous leukemia (CML) and precursor B cell acute lymphoblastic leukemia (B-ALL). Examination of the pathophysiology ...

Energy Technology Data Exchange (ETDEWEB)

Abstract not provided

UK PubMed Central (United Kingdom)

BackgroundThe maternally inherited, bacterial symbiont, parthenogenesis inducing (PI) Wolbachia, causes females in some haplodiploid insects to produce daughters...Full Text Available

British Library Electronic Table of Contents (United Kingdom)

Parthenogenesis-inducing (PI) Wolbachia belong to a class of intracellular symbionts that distort the offspring sex ratio of their hosts toward a female bias. In many PI Wolbachia-infected species sex ratio distortion has reached its ultimate expression-fixation of infection and all-female populations. This is only possible with thelytokous PI symbionts as they provide an alternative form of reproduction and remove the requirement for males and sexual reproduction. Many populations fixed for PI Wolbachia infection have lost the ability to reproduce sexually, even when cured of the infection. We examine one such population in the species Trichogramma pretiosum. Through a series of backcrossing experiments with an uninfected Trichogramma pretiosum population we were able to show that the gen...

UK PubMed Central (United Kingdom)

Listeria monocytogenes, isolated from outbreaks in either human or nonhuman primate populations, was administered orally at doses ranging from 10⁶ to 10¹⁰ CFU....Full Text Available

UK PubMed Central (United Kingdom)

In rats, damage to neuronal populations in some brain regions occurs in response to neonatal alcohol exposure coinciding with the period of rapid brain growth. These alcohol-induced defects...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Biomonitoring of human populations for exposure to genotoxic/clastogenic agents in the environment or the workplace must depend upon statistical tests for elevations in the frequencies of the biological endpoints being monitored, usually chromosomal aberrations (CA), micronuclei (MN), or sister chromatid exchanges (SCE) in peripheral blood lymphocytes. Statistical tests are based, in turn, upon certain assumptions regarding the distribution of the test statistic. When they are often not recognized as such, tests of significance can be in error, and any conclusion drawn that there is or is not a statistically significant difference between one population sample and another maybe erroneous. In population monitoring this means either false negatives or false positives can result and it is hard to know which is worse. Furthermore, even the intelligent design of studies whose object is to test for an elevated level in an exposed ...

British Library Electronic Table of Contents (United Kingdom)

Primary B-cell lymphoma of thymus is uncommon. We describe the case of a 23-year-old woman with a history of shortness of breath and distended neck veins of 1-month duration. A chest roentgenogram and computed tomographic chest scan of the showed a large anterior mediastinal mass. Tru-cut biopsy revealed primary B-cell lymphoma of thymus. She underwent chemotherapy with no symptomatic improvement. Post-chemotherapy computed tomographic scan of the chest showed no appreciable reduction in tumor size. Surgical excision was carried out with excellent results.

Energy Technology Data Exchange (ETDEWEB)

Data are presented to support the hypothesis that the initial step in the morphologic transformation of irradiated rodent (BALB/3T3) cells is a frequent cellular event involving a large fraction of the irradiated population. This process appears to involve DNA damage, but not to represent a targeted mutation in specific structural gene(s). Morphologic transformation and immortalization appear to be distinct steps in the overall process of transformation. In contradistinction to rodent cells, immortalization is a very rare event in human diploid cells which is induced at extremely low frequencies. The hypothesis is presented that immortality develops among clones of cells bearing stable chromosomal rearrangements which emerge during the proliferation of a population of radiation damaged cells.

Energy Technology Data Exchange (ETDEWEB)

Survival curves were constructed from dose-incidence curves for apoptosis in the crypts of mouse small intestine, using the number of apoptotic cells after high doses (N{sub M}) as maximum cell population size. The mean lethal doses (D{sub 0}) for the dose range 0-0.5 Gy were calculated for each time of day. A circadian rhythm in both D{sub 0} and N{sub M} values was detected, indicating that both the number and sensitivity of radiation-induced apoptosis were changing throughout the day. (author).

British Library Electronic Table of Contents (United Kingdom)

Biased above threshold (VT), pulsed photocurrent (u) measurements on windowed silicon Pd gate MOS capacitors are shifted (DV) negatively by H2/N2, whereas Au gates shift positively under NO2/air. Below VT, the shifts are reversed by adjustments of interface state population. Minor temperature increases may coax the device from inversion to depletion, inducing sign reversal of the chemical response.

UK PubMed Central (United Kingdom)

The CNS is a unique organ due to its limited capacity for immune surveillance. As macrophages of the CNS, microglia represent a population originally known for the ability to assist neuronal stability,...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

We have been investigating radiation-induced neoplastic transformants of C3H 10T1/2 mouse fibroblasts for evidence of heritable changes. C3H 10T1/2 cells were treated with 8 Gy X rays. After approximately 8 weeks of culture, type II/III foci were isolated from the monolayer using cloning rings. Cell lines developed from these foci, and clones established from these cell lines, were examined for DNA content. The isolated focus-derived populations and derived clones often display aneuploidy and/or polyploidization. In one instance a clone (derived from a single cell) displayed multiple polyploidies. During passage the ploidy of many of the anomalous populations gradually reverted to the ploidy of the non-neoplastically transformed state. The morphological features associated with the neoplastic transformation event were nevertheless retained. The results demonstrate that exposure to radiation can induce, ...

UK PubMed Central (United Kingdom)

We studied telomeric DNA in leukemic cells as well as in normal T cells, B cells, monocytes, polymorphonuclear leukocytes, and bone marrow hematopoietic progenitor cells. No marked differences were...Full Text Available

UK PubMed Central (United Kingdom)

SummaryMonoclonal antibodies are standard therapeutics for several cancers including the anti-CD20 antibody rituximab for B cell non-Hodgkin lymphoma (NHL). Rituximab and other...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Microbial dechlorination of polychlorinated biphenyls (PCBs) often stops although a significant number of removable chlorines remain. To determine the reason for the cessation, we investigated the limitation of organic carbon, PCB bioavailability, and inhibition by metabolic products. Enrichment with carbon sources did not induce additional chlorination, indicating the plateau was not due to depletion of organic carbon. The bioavailability was not limiting, since a subcritical micelle concentration of the surfactant, which enhanced desorption without inhibiting dechlorinating microorganisms, failed to lower the plateau. Neither was it due to accumulation of metabolites, since no additional dechlorination was detected when plateau sediments were incubated with fresh medium. Similarly, dechlorination was not inhibited in freshly spiked sediment slurries. Dechlorination ended up at the same level with nearly identical congener profiles, regardless of treatment. These ...

International Nuclear Information System (INIS)

The "1"3"1-radioiodine use in Guanabara area, during 1972-1973, is analysed. References are made to the radiation levels delivered to thyroid, bone marrow and gonads in a population of 27000 people examined by tracer techniques, 190 submitted to hyperthyroidism treatment and 50 treated for thyroid cancer. The pertinent literature gives some data concerning radiation induced cancer (leukaemia and thyroid cancer). By this, it was possible to estimate the probability of tumour occurrence in that population, assuming a linear relationship between dose and effect. The conclusions are the followings: 1 - there are many duties in this field at the present; 2 - the leukaemia incidence related to the 131-radioiodine use is negligible, either in diagnostic or therapeutic modalities; 3 - the possibility of thyroid tumors induced by radiation is real, specially in hyperthyroidism treatment; 4 - the use of tracer ...

International Nuclear Information System (INIS)

In defining criteria for good protection against ionizing radiation, it is important to assess quantitatively the likely risk of any radiation exposure. The 'somatic' risks to the individual result mainly from induction of cancer in the organs irradiated, and these risks can now be estimated on the basis of numerous detailed epidemiological surveys of exposed human populations. Estimates of the risk of hereditary effects, from genetic changes induced in germ cells, are based largely on the frequency with which such effects are induced in other species. In both cases the risk at very low dose can be inferred using knowledge of the way in which radiation damage is caused in tissues. Coherent systems of radiation protection are based on a restriction of doses to the whole body and to individual organs, such that the induction of cancer and genetic harm is infrequent, and the threshold dose for causing other, 'non-stochastic', ...

International Nuclear Information System (INIS)

Nano indentation analysis and transmission electron microscopy observation were performed to investigate a microstructural evolution and its influence on the hardening behavior in Fe-Cr alloys after an irradiation with 8 MeV Fe4+ ions at room temperature. Nano indentation analysis shows that an irradiation induced hardening is generated more considerably in the Fe-15Cr alloy than in the Fe-5Cr alloy by the ion irradiation. TEM observation reveals a significant population of the a0 dislocation loops in the Fe-15Cr alloy and an agglomeration of the 1/2a0 dislocation loops in the Fe-5Cr alloy. The results indicate that the a0 dislocation loops will act as stronger obstacles to a dislocation motion than 1/2a0 dislocation loops.

Energy Technology Data Exchange (ETDEWEB)

The energy spectra of few-nucleon transfer reactions obtained by bombarding a /sup 197/Au nucleus with the 341 MeV /sup 20/Ne beam of the Berkeley cyclotron have been analysed successfully in terms of direct surface transfer reactions populating the continuum states. At the grazing angle we are dealing with one-step processes; at forward angle two-step processes have to be taken into account.

Energy Technology Data Exchange (ETDEWEB)

The proposed short wavelength coherent light source driven by the SLAC 3 km linac might be used to induce transitions between nuclear isomeric states. If an isotope were found with energetically adjacent isomeric states, one short-lived and one long-lived, and it were possible to separate and concentrate the long-lived species, and other nuclear and solid-state parameters were favorable, it might be possible to convert sufficient population to the short-lived state to realize [gamma]-ray lasing. Even if the x-ray intensity were insufficient, study of such driven transitions would be quite valuable.

International Nuclear Information System (INIS)

The most important factor in assessing radiologic risk is ensuring scientific means for evaluation of the radioactive release impact upon humans and organisms. To evaluate quantitatively this impact not only knowledge of radioactivity distribution in these dynamical systems is necessary but also understanding the transfer mechanisms between ecosystem components is needed. Thus a complete radioecologic study appear to be very complex and needs defining the source term, dynamic description of radionuclides behavior in the ecosystem, estimation of radiation doses in the major components of the ecosystem and finally the effects of radiation doses upon different parts of the systems. A diagram of the steps implied in evaluation of the effects due to radioactive effluent release in the environment is presented and discussed. The following steps are described: - identification of radioactive sources, as well as their input rate. Presence of noxious materials such as heavy metals or some ...

Science.gov (United States)

Description of how global warming could be disastrous for much of the earth's population....

Energy Technology Data Exchange (ETDEWEB)

The growing concern of the population with regards to the problem of atmospheric pollution has induced a change in the role of air quality monitoring networks, especially those monitoring air pollution in large cities which suffer from summer smog. The population is no longer satisfied with real-time measurements but wants to be warmed of high pollutants concentrations in advance. Some countries have been forecasting air pollution, and especially ozone, for a large number of years. Although most of them use statistical models based on the analyses of past conditions which induced high pollution episodes, some predict ozone levels using only their knowledge of the meteorological situation. Nowadays two trends appear regarding ozone forecasting: either very basic statistical methods, such as regression, or more sophisticated ones, such as neural networks. The paper then reviews several behaviours common ...

Energy Technology Data Exchange (ETDEWEB)

Glycosaminoglycan synthesis was studied in cell populations of ultraviolet light-induced murine cutaneous fibrosarcoma cells under conditions of varying growth rates in vitro. After labeling with the precursors, /sup 3/H-glucosamine and /sup 35/SO/sub 4/, sulfated glycosaminoglycans recoverable by direct proteolysis of the culture monolayers increased approximately 5-fold on a per cell basis from sparsely populated, exponential cell cultures (greater than 85% of cells in S, G2, or M phases) to stationary cultures inhibited by high cell density (greater than 50% of cells in G1). Within this cell surface-associated material, the relative ratio of heparan sulfate to the chondroitin sulfates was approximately 60/40% under conditions of exponential growth; in the growth-arrested cultures, the reverse ratio was found. The substratum attached material, obtained from the flask surface after ethyl glycol bis(beta-aminoethyl ...

British Library Electronic Table of Contents (United Kingdom)

Abstract. Objective: Lapatinib (Tykerb, GW572016), a potent inhibitor of the catalytic activities of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) (ErbB2), inhibits population growth of selected EGFR and HER2 overexpressing cell lines. Previous studies with a small number of cell lines suggest a correlation between overexpression of EGFR and/or HER2 and sensitivity to growth inhibition by lapatinib; however, the precise determinants of lapatinib selectivity for tumour and/or other cells remain unclear. Materials and methods: To clarify the determinants of its selectivity in cultured cells, lapatinib-induced cell population growth inhibition and relative EGFR and HER2 protein expression were quantified in 61 different human tumour cell lines fro...

Science.gov (United States)

Candoxin (PDB #1JGK), a three-finger neurotoxin from Bungarus candidus venom, inhibits post-synaptic neuromuscular and neuronal alpha7nACh-receptors, and induces delayed cell-death throughout the glial population. When applied to cultured human glial cell lines, candoxin (CDX) induced cell death in a concentration (EC(50) approximately 1muM) and time dependent manner. Results of TUNEL-histochemistry further confirm CDX-induced brain (hippocampus, frontal cortex, and temporal regions) damage when administered intracerebroventricularly (i.c.v) in adult mice. In this study, we explored differential gene expression profiles following exposure of human glial (Hs 683) cell lines to CDX at various time intervals using Affymetrix-GeneChips. By means of MAS and GeneSpring analyses, 105 genes whose expression was significantly (P<0.01) altered by at least 3-fold were selected. Results of the genome analysis ...

Science.gov (United States)

Hepatocellular carcinoma (HCC) is considered to be one of the most common malignancies worldwide, and the most common one in Africa and Asia. Over the last decade, a rising incidence of up to 10-15/100,000 per population has been seen in the Western world, with an estimate of 250,000 deaths and more than a million worldwide per year. By the year 2010, the World Health Organization expects that HCC will be the leading cause of cancer mortality surpassing lung cancer. This increasing incidence is most likely related to an increasing prevalence of chronic hepatitis C (HC) and B (HB) virus infections and other diseases inducing chronic inflammation (Befeler and Di Bisceglie 2002; Llovet et al. 2003).

British Library Electronic Table of Contents (United Kingdom)

Acidification is one of the most common and serious problems inducing process failure in anaerobic digesters. The production of volatile fatty acids (VFAs) mainly triggers acidic shock. However, little is known about the bacteria involved in the processes of acidogenic metabolism, such as fermentation and reductive acetogenesis. Here, the metabolic responses of a methanogenic community to the acidification and resulting process deterioration were investigated using transcriptional profiling of both the 16S rRNA and formyltetrahydrofolate synthetase (FTHFS) genes. The 16S rRNA-based analyses demonstrated that the dynamic shift of bacterial populations was closely correlated with reactor performance, especially with VFA accumulation levels. The pH drop accompanied by an increase in VFAs stim...

British Library Electronic Table of Contents (United Kingdom)

Ground deformation affecting the Umbria region (central Italy) in the 9-year period from 1992 to 2000 was investigated through multi-temporal Differential Synthetic Aperture Radar Interferometry (DInSAR). For the purpose, the Small BAseline Subset (SBAS) technique was adopted, which allows studying the temporal evolution of the detected deformation at two spatial scales: a low-resolution (regional) scale, and a full-resolution (local) scale. For the analysis, SAR data acquired by the European Remote Sensing (ERS-1/2) satellites along ascending and descending orbits were used. The detected deformation was analysed to investigate its relevance to geophysical, geomorphologic, and human-induced processes that may result in hazardous conditions to the population of Umbria. Low-resolution deform...

UK PubMed Central (United Kingdom)

The Epstein-Barr virus protein, LMP1, is a functional mimic of the cellular receptor CD40, but signals to B lymphocytes in an amplified and sustained manner compared to CD40. LMP1 contributes...Full Text Available

International Nuclear Information System (INIS)

The aim of this paper is offering a critical review of Calibration-Free Laser-Induced Breakdown Spectroscopy (CF-LIBS), the approach of multi-elemental quantitative analysis of LIBS spectra, based on the measurement of line intensities and plasma properties (plasma electron density and temperature) and on the assumption of a Boltzmann population of excited levels, which does not require the use of calibration curves or matrix-matched standards. The first part of this review focuses on the applications of the CF-LIBS method. Quantitative results reported in the literature, obtained in the analysis of various materials and in a wide range of experimental conditions, are summarized, with a special emphasis on the departure from nominal composition values. The second part is a discussion of the simplifying assumptions which lie at the basis of the CF-LIBS algorithm (stoichiometric ablation and complete atomization, thermal equilibrium, homogeneous ...

Science.gov (United States)

The objective of this animation is to develop a QTL mapping population for locating and characterizing the genes responsible for resistance to tan spot disease of wheat.

International Nuclear Information System (INIS)

Post-irradiation annealing was used to help identify the role of radiation-induced segregation (RIS) in irradiation-assisted stress corrosion cracking (IASCC) by preferentially removing dislocation loop damage from proton-irradiated austenitic stainless steels while leaving the RIS of major and minor alloying elements largely unchanged. The goal of this study is to better understand the underlying mechanisms of IASCC. Simulations of post-irradiation annealing of RIS and dislocation loop microstructure predicted that dislocation loops would be removed preferentially over RIS due to both thermodynamic and kinetic considerations. To verify the simulation predictions, a series of post-irradiation annealing experiments were performed. Both a high purity 304L (HP-304L) and a commercial purity 304 (CP-304) stainless steel alloy were irradiated with 3.2 MeV protons at 360 deg. C to doses of 1.0 and 2.5 dpa. Following irradiation, post-irradiation anneals were performed at ...

British Library Electronic Table of Contents (United Kingdom)

Surveillance of a population, such as a weapon stockpile, is needed to discover manufacturing defects as well as deterioration as the population ages. This article considers the risks of sampling rates for surveillance from three perspectives: detection probability of defects in a proportion of a population with pass/fail data, detection of a trend in a defective proportion of the population with pass/fail data, and detection of a trend with quantitative degradation measurements. Understanding of these risks will help the decision maker choose a sampling rate to protect against such problems of a specified size at a tolerable risk.

International Nuclear Information System (INIS)

Full text: The maturation of chicken forebrain is protracted and occurs well after synapse formation providing a good model for studying mechanisms of brain maturation. Using microslices from immature (10 day) and adult chicken forebrain prepared after decapitation, we have examined functional properties of NMDA and AMPA receptors by measuring agonist-induced uptake of "4"5Ca"2"+ . The rate and extent of NMDA induced "4"5Ca"2"+ accumulation decreased during maturation with no change in EC_5_0. The rate and extent of the AMPA induced response also decreased with a 60-fold increase in EC_5_0. However, the total NMDA receptor content did not change as indicated by 3 H-MK801 binding and NR1 immunoreactivity in P2 fractions. Similarly, there was no change in the B_m_a_x of "3H-AMPA, though there was a two-fold increase in K_D, and little or no change in the immunoreactivity in GluR1, 2, 2/3 or 4. These results suggest that it is ...

UK PubMed Central (United Kingdom)

Linkage disequilibrium (LD) between densely spaced, polymorphic genetic markers in humans and other species contains information about historical population size. Inferring past population size is of...Full Text Available

International Nuclear Information System (INIS)

The present investigation was conducted at Ismaillia Research Station-Agricultural Research Center, Ismaillia Governorate, during the two successive seasons of 2000 and 2001. Two varieties of peanut (Arachis hypogaea L) namely Giza 4 and Giza 5 were treated with gamma ray doses; 10,15, 20, 25 Kr in order to induce genetic variability and to study the importance of the relative contribution of peanut yield components by employing some statistical procedures, i.e. simple correlation, multiple linear regression and stepwise regression analysis. The results showed that, there was significant positive correlation between seed yield/plant and no. of pods/plant, 100 seed weight, shelling percentage and pod yield/plant, and there was significant positive correlation between pod yield/plant and no of seed/plant,100 pod weight and 100 seed weight. The multiple linear regression analysis clearly showed that the relative contribution (R"2%) of the yield components, no. of ...

Science.gov (United States)

Through DNA methylation, histone modifications, and small regulatory RNAs the epigenome systematically controls gene expression during development, both in utero and throughout life. The epigenome is also a very reactive system; its labile nature allows it to sense and respond to environmental perturbations to ensure survival during fetal growth. This pliability can lead to aberrant epigenetic modifications that persist into later life and induce numerous disease states. Endocrine-disrupting compounds (EDCs) are ubiquitous chemicals that interfere with growth and development. Several EDCs also interfere with epigenetic programming. The investigation of the epigenotoxic effects of bisphenol A (BPA), an EDC used in the production of plastics and resins, has further raised concern over the impact of EDCs on the epigenome. Using the Agouti viable yellow (A(vy)) mouse model, dietary BPA exposure was shown to hypomethylate both the A(vy) and the Cabp(IAP) metastable ...

Energy Technology Data Exchange (ETDEWEB)

This paper reports that some regions have prepared for these days of disposal shortage with comprehensive waste plans that include a strong WTE presence. Witness Broward County, Florida's program, 12 years in planning by public and private entities, Broward is the second most populated county in the state, with 1.3 million residents and a heavy tourist population, which, together, produce 1.6 million tons of waste annually. The disposal program includes Waste Management, Inc.'s expansion of a 400-acre Central Disposal Sanitary Landfill, the county's new 588-acre landfill, composting, and curbside pickup for recyclables. And, this south Florida plan would not be complete without the two brand new combustion plants. Clean Air and Water Acts notwithstanding, the Florida Department of Environmental Regulation can induce standards stricter than the federal government's due to the sensitive ...

UK PubMed Central (United Kingdom)

PurposeTo describe the prevalence of cataract in older people in 2 areas of north and south India.DesignPopulation-based, cross-sectional study.ParticipantsRandomly...Full Text Available

Science.gov (United States)

Coral are symbiotic with photosynthetic dinoflagellates from the genus Symbiodinium. There are eight divergent clades (A-H) within the genus which each ... ...

Science.gov (United States)

... some Central Asian populations (Zerjal et al. 2002). Haplogroup W has a similar Middle Eastern origin, and again ... ...

Energy Technology Data Exchange (ETDEWEB)

The maintenance of a balance between cell gain and cell loss is essential for proper liver function. The exact role of aryl hydrocarbon receptor (AhR) in regulating cell proliferation and apoptosis of liver cells remains unclear, since ligand-dependent activation of AhR has been shown to induce cell cycle arrest, proliferation, differentiation or apoptosis, depending on the cellular model used. AhR can directly interact with retinoblastoma protein in hepatic cells, forming protein complexes that can efficiently block cell cycle progression by inducing G1 arrest, or to induce the expression of inhibitors of cyclin-dependent kinases, such as p271. On the other hand, it has been suggested that AhR could play a stimulatory role in cell proliferation, either directly or by mediating a release from contact inhibition. It is now generally accepted that progenitor cells exist in the liver, are activated in various liver diseases ...

Energy Technology Data Exchange (ETDEWEB)

Small unilamellar vesicles which form when gel-state long-chain phosphatidylcholines are mixed with micellar short-chain lecithins undergo an increase in size as the long-chain species melts to its liquid-crystalline form. Analysis of the vesicle population with quasi-elastic light scattering shows that the particle size increases from 90-A radius to greater than 5000-A radius. Resonance energy transfer experiments show total mixing of lipid probes with unlabeled vesicles only when the Tm of the long-chain phosphatidylcholine is exceeded. This implies that the large size change represents a fusion process. Aqueous compartments are also mixed during this transition. 31P NMR analysis of the vesicle mixtures above the phase transition shows a great degree of heterogeneity with large unilamellar particles coexisting with oligo- and multilamellar structures. Upon cooling the vesicles below the Tm, the original size distribution (e.g., small unilamellar vesicles) is ...

International Nuclear Information System (INIS)

One rationale proposals to increase the efficiency of PDT is to combine photo-sensitization with other treatment modalities, including modulation of arachidonic acid metabolism. In combine treatment we examined the effects of 48 h and 24 h pre-treatment of cells with 5- lipoxygenase inhibitor MK-886 prior to photoactivation of hypericin on cell cycle distribution and DNA synthesis. All parameters were examined 24 hours after hypericin activation. Pre-treatment of HT-29 with 5-lipoxygenase inhibitor MK-886 followed by PDT resulted in most significant effects on cell cycle perturbations. Administration of MK-886 alone as well as combination of low doses MK-886 with hypericin induced S phase accumulation. Increasing of MK-886 concentration induced massive changes in the cell cycle progression. Pre-treatment of HT-29 cells with MK-886 alone (15 #mu#M; - 48 h) caused accumulation of cells in S-phase (58 % in S-phase and 36 % in G_0/G_1 phase). ...

International Nuclear Information System (INIS)

... radiation effects human populations low dose irradiation neoplasms radiation

International Nuclear Information System (INIS)

Short communication.

Science.gov (United States)

PMID:11395306

KoreaScience (Korea)

Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Passage through dams is a major source of mortality of anadromous juvenile salmonids because some populations must negotiate up to eight dams in Columbia and Snake rivers. Dams cause direct mortality when fish pass through turbines, but dams may also cause indirect mortality by altering migration conditions in rivers. Forebays immediately upstream of dams have decreased the water velocity of rivers and may contribute substantially to the total migration delay of juvenile salmonids. Recently, Coutant (2001a) suggested that in addition to low water velocities, lack of natural turbulence may contribute to migration delay by causing fish to lose directional cues. Coutant (2001a) further hypothesized that restoring turbulence in dam forebays may reduce migration delay by providing directional cues that allow fish to find passage routes more quickly (Coutant 2001a). Although field experiments have yielded proof of the concept of using induced ...

British Library Electronic Table of Contents (United Kingdom)

Native plant individuals often persist within communities dominated by exotics but the influence of this exposure on native populations is poorly understood. Selection for traits contributing to competitive ability may lead to native plant populations that are more tolerant of the presence of exotic invaders. In this way, long-term coexistence with an exotic may confer competitive advantages to remnant (experienced) native populations and be potentially beneficial to restoration. In past studies we have documented genetic differentiation within native grass populations exposed to the exotic invader Russian knapweed (Acroptilon repens). Here, we examine populations of a cool-season grass, needle-and-thread (Hesperostipa comata [Trin. & Rupr.]) and a warm season, alkali sacaton (Sporobolus a...

Energy Technology Data Exchange (ETDEWEB)

Populations living close to high-voltage transmission lines often have residential magnetic field exposures in excess of 1 [mu]T, and sometimes over 2 [mu]T. Yet, populations studied in most epidemiologic investigations of the association between residential magnetic field exposure and cancer typically have exposures below 1 [mu]T and frequently below 0.5 [mu]T. To improve statistical power and precision, it would be useful to compare high exposure populations with low exposure population. Toward this end, we have developed an automated method for identifying populations living near high-voltage transmissions lines. These populations likely have more highly exposed individuals that the population at large. The method uses a geographic information system (GIS) to superimpose digitized transmission line locations on U.S. Census block location ...

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

Science.gov (United States)

Skip to Content Cancer Control and Population Sciences Home Applied Research Home Risk Factor Monitoring and Methods Home Diet Usual Dietary Intakes: Background The NCI Method Details of the NCI Method Food Intakes, US Population, 2001-04 Selected Intakes

UK PubMed Central (United Kingdom)

A population based survey of trachoma and blindness was conducted in a rural Nile Delta hamlet. Trachoma remains hyperendemic in this region. Active trachoma was common among preschool children; over...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundDespite having the largest population in Africa, Nigeria has no accurate population based data to plan and evaluate eye care services. A national survey was undertaken...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSeverely disabling chronic pain in the adult population is strongly associated with a range of negative health consequences for individuals and high health care costs,...Full Text Available

UK PubMed Central (United Kingdom)

ObjectivesMild Cognitive Impairment (MCI) case-finding criteria have low specificity in general population studies. The present study retrospectively identifies cases...Full Text Available

UK PubMed Central (United Kingdom)

Production of dissolved macromolecules by ambient autotrophic and heterotrophic microbial populations was measured in a eutrophic Florida reservoir by in situ labeling with various radioactive substrates....Full Text Available

UK PubMed Central (United Kingdom)

An explicit proposal for experiments leading to abrupt transitions in spatially extended bacterial populations in a Petri dish is presented on the basis of an exact formula obtained through an analytic...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVES. In this study we tested the association between occupational stress--as measured by job demands, decision latitude, and job strain--and hypertension in a population of 1396 Black and White...Full Text Available

UK PubMed Central (United Kingdom)

The selection due to the "healthy worker effect" was estimated from a random sample of the total Finnish population. The sample of 20 000 people was followed for changes in occupations from 1960 to...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundBengal tiger Panthera tigris tigris the National Animal of India, is an endangered species. Estimating populations for such species is the main objective...Full Text Available

UK PubMed Central (United Kingdom)

AIMS: To examine the frequency of intraocular metastases in patients who had died of cancer, in an eye bank and necropsy population sample. METHODS: The first group included 302 cancer cases received...Full Text Available

UK PubMed Central (United Kingdom)

The effective population size (N_e) is an important parameter in ecology, evolutionary biology and conservation biology. It is, however, notoriously difficult to estimate,...Full Text Available

UK PubMed Central (United Kingdom)

The roles played by environmental factors in seasonal changes in microbial populations were investigated in the Tvärminne area, off the southern coast of Finland. Surface-layer samples were...Full Text Available

UK PubMed Central (United Kingdom)

The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design....Full Text Available

UK PubMed Central (United Kingdom)

AimsTo develop a population pharmacokinetic model for maraviroc, a noncompetitive CCR5 antagonist, after oral administration of tablets to healthy volunteers and asymptomatic HIV-infected...Full Text Available

Science.gov (United States)

We report on the results of a preliminary study of the GCR-induced photon luminescence of the Moon

DEFF Research Database (Denmark)

Published online before print October 4

Science.gov (United States)

Carotid Artery Disease; Stroke; Amaurosis Fugax; Transient Ischemic Attack (TIA)

Science.gov (United States)

Variation for wheat (Triticum aestivum L.) grain yield and its component traits was documented in a `Cheyenne¿ x Cheyenne (`Wichita¿ 3A) recombinant inbred chromosome line population. In the present study, a population of 223 Cheyenne (Wichita 3A) recombinant inbred chromosome lines was used to map ...

International Nuclear Information System (INIS)

Since 1945, more than 1.8 x 10"2"1 Bq of artificial radionuclides have been released into the atmosphere. Approximately 2.04 x 10"1"8B, i.e. approx. 0.11%, are the result of accidents at nuclear industrial facilities. This percentage is causing increased interest among researchers. This is due to the fact that in the wake of accidental release radionuclides become distributed unevenly across the Earth's surface, and the associated exposures, fluctuating from background level to several grays, an induce both stochastic and deterministic effects in the irradiated population. A comparative analysis of the medical consequences of the twentieth century's most serious nuclear events, namely the authorized dumping of high level radioactive waste into the river Techa in 1950, the explosion of a storage tank containing long lived radioactive waste in the Southern Urals in 1957, the fire at Sellafield in 1957 and the accident at the Chernobyl nuclear ...

Energy Technology Data Exchange (ETDEWEB)

A transplant experiment was conducted to determine whether standard metabolic rate (SMR) of a freshwater shrimp (Palaeomonetes paludosus) would be affected by exposure to trace element-enriched coal combustion waste (coal ash). Shrimp were transplanted into replicate cages in a coal ash-polluted site and a reference site for 8 months. The coal ash-polluted site was characterized by elevated sediment concentrations of As, Cd, Cr, Cu, Ni, Pb and Se compared to sediments in the reference site. After 8 months in the study sites, shrimp in the polluted site appeared to have accumulated As, Cd and Se from the habitat, but there were on differences in survival between the study sites. However, mean SMR of shrimp (measured as O{sub 2} consumption at rest) held in the polluted site was 51% higher than mean SMR of shrimp held in the reference site. The elevation in SMR indicates that the energetic costs of maintenance are greater for shrimp chronically exposed to the coal-ash polluted enviorment ...

Energy Technology Data Exchange (ETDEWEB)

This RD&D project is a three year team effort to develop a hybrid solar lighting (HSL) system that transports daylight from a paraboloidal dish concentrator to a luminaire via a bundle of small core or a large core polymer fiber optics. The luminaire can be a device to distribute sunlight into a space for the production of algae or it can be a device that is a combination of daylighting and electric lighting for space/task lighting. In this project, the sunlight is collected using a one-meter paraboloidal concentrator dish with two-axis tracking. For the second generation (alpha) system, the secondary mirror is an ellipsoidal mirror that directs the visible light into a bundle of small-core fibers. The IR spectrum is filtered out to minimize unnecessary heating at the fiber entrance region. This report describes the following investigations of various aspects of the system. Taken as a whole, they confirm significant progress towards the technical feasibility and commercial ...

International Nuclear Information System (INIS)

The GSD must be considered as a quantity by means of which the risk in a given population can be described exclusively in terms of genetic risk. In cases of a simultaneous increase in the rate of examinations, the GSD may lead to a misinterpretation of the population exposure, suggesting a decreasing trend, although there is an actual increase in the somatic radiation exposure. It is recommended to indicate not only the GSD but also the amount of somatic radiation exposure of the population for each specific source when comparing and evaluating radiation exposures from different sources. Although the somatically significant dose formally would be suited as a complement to the GSD, it is recommended to use the effective per caput dose equivalent. It must be pointed out that the application of the concept of effective dose equivalent is only appropriate for comparative evaluations of the population ...

International Nuclear Information System (INIS)

The genetically significant dose (GSD) is an index variable which exclusively allows to describe the genetic risk in the progeny of a population due to the application of ionizing radiation and radioactive substances in one part of this population. It may result in wrong interpretation of population exposure at increasing incidence of examinations in a population involving ionizing radiation and radioactive drugs at simultaneously increasing application of alternative methods in children and adolescents owing to the fact that it indicates a downward trend although somatic exposure of this population has increased. Therefore, it is recommended to state both the GSD and the level of somatic radiation exposure of the population taken from the individual sources for the comparison and assessment of radiation exposure from various sources in future. Although the ...

UK PubMed Central (United Kingdom)

BackgroundIsoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease. In this study, we compared the transcriptional response...Full Text Available

International Nuclear Information System (INIS)

The author derives to which of the three types an irreducible UA representation which is obtained with the procedure of generalised induction belongs. The question whether or not the irreducible induced UA representations are on standardform is analysed. The results hold as well for induced PUA representations. (Auth.).

UK PubMed Central (United Kingdom)

We introduce cyclophosphamide-induced alopecia (CYP-IA) in C57BL-6 mice as a clinically relevant model for studying the biology of chemotherapy-induced alopecia and for developing anti-alopecia drugs....Full Text Available

CERN Document Server

In a recent survey of the stellar populations of LINERS and LINER/HII Transition Objects (TOs) we identified a numerous class of nuclei which stand out because of their conspicuous 10^8-9 yr populations. These objects were called ``Young-TOs'', since they all have TO-like emission line ratios. In this paper we investigate the radial variations of spectral properties in Low Luminosity AGN. Our analysis is based on high S/N, 3500-5500 A, long-slit spectra for 47 galaxies. The data probe distances of typically up to 850 pc from the nucleus with a resolution of ~ 100 pc and S/N ~ 30. Stellar population gradients are mapped by the radial profiles of absorption line equivalent widths and colours along the slit. These variations are further analyzed by means of a decomposition of each spectrum in terms of template galaxies representative of very young (<= 10^7 yr), intermediate age (10^8-9 yr) and old (10^10 yr) ...

Science.gov (United States)

Examination of measurement invariance provides a powerful method to evaluate the hypothesis that the same set of psychological constructs underlies a set of test scores in different populations. If measurement invariance is observed, then the same psychological meaning can be ascribed to scores in both populations. In this study, the measurement model including core and supplementary subtests of the Wechsler Adult Intelligence Scale-Fourth edition (WAIS-IV) were compared across the U.S. and Canadian standardization samples. Populations were compared on the 15 subtest version of the test in people aged 70 and younger and on the 12 subtest version in people aged 70 or older. Results indicated that a slightly modified version of the four-factor model reported in the WAIS-IV technical manual provided the best fit in both populations and in both age groups. The null hypothesis of measurement invariance ...

UK PubMed Central (United Kingdom)

Several organophosphate and organochlorine compounds, including pesticides commonly found in the Great Lakes basin, have the potential to induce immunotoxicity. Because of biomagnification and accumulation...Full Text Available

UK PubMed Central (United Kingdom)

Lens-induced glaucoma comprises a number of different glaucomatous processes occurring in the elderly that share in common the role of the crystalline lens in the mechanism of increase in intraocular...Full Text Available

CERN Document Server

Differences in synchrotron radiation induced gas desorption from stainless steel and aluminium alloy

UK PubMed Central (United Kingdom)

We determined the underlying aetiology of blindness for the registered blind population of the Province of Newfoundland and Labrador. In both 1981 and 1984 single-gene disorders accounted for 30% of...Full Text Available

UK PubMed Central (United Kingdom)

PurposeTo describe etiologies and clinical characteristics of corneal opacities leading patients to seek cosmetic treatments.MethodsThe medical records...Full Text Available

UK PubMed Central (United Kingdom)

IntroductionShoulder pain covers a wide range of problems and affects up to 20% of the population. It is not a specific diagnosis. Shoulder pain can be caused by problems with the...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

The resident bald eagles of the lower Columbia River have lower productivity and higher contaminant levels than other bald eagles of the Pacific Northwest. The primary population stressors are believed to be habitat loss, human disturbance, p,p{prime}DDE, PCBs, dioxins and furans. The primary effect of habitat loss is to reduce the carrying capacity of the region for nesting sites, and the primary effects of human disturbance and contamination by organic compounds are to reduce productivity. The purpose of this study was to quantitatively evaluate the effects of all of, these potential stressors on the bald eagle population dynamics. A model of the population dynamics was developed. The model structure includes a physiologically-based toxicokinetic (PBTK) submodel to estimate the degree of contamination, which is linked via a toxicology submodel to a population dynamics submodel. The PBTK submodel is ...

UK PubMed Central (United Kingdom)

Despite advances in standard of living of the population, the condition of widows and divorced women remains deplorable in society. The situation is worse in developing nations with their unique social,...Full Text Available

UK PubMed Central (United Kingdom)

The geographical arrangement of people on the surface of the earth is approximated by a mathematical equation of 361 terms. This is a convenient form for comparison with other distributions and for...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVE: This study evaluated, in a large, heterogeneous population, the outcome of open cholecystectomy as it is currently practiced. SUMMARY BACKGROUND AND DATA: Although cholecystectomy has been...Full Text Available

UK PubMed Central (United Kingdom)

ABSTRACTOBJECTIVETo explore the prevalence and the demographic predictors of nonmedical use of opioid analgesics in the Canadian adolescent population.DESIGNData...Full Text Available

UK PubMed Central (United Kingdom)

Background and AimsIt is well known that genome size differs among species. However, information on the variation and dynamics of genome size in wild populations and on the early...Full Text Available

Science.gov (United States)

Genetics, Genomics, and Molecular Biology USGS scientists develop and integrate new genetic and molecular techniques into systematic analyses to describe individuals and populations of fish .....

Science.gov (United States)

... Characterizing the Relative Contributions of Large Vessels to Total Ocean Noise Fields: A Case Study Using the Gerry E. ... ...

Science.gov (United States)

... African agro-pastoral system: Management of tsetse and bovine trypanosomiasis. Ecological Economics 65:1, 125-135Online publication date: ... ...

KoreaScience (Korea)

Full Text Available

UK PubMed Central (United Kingdom)

The study of genetic variability within natural populations of pathogens may provide insight into their evolution and pathogenesis. We used a Mycobacterium tuberculosis high-density...Full Text Available

Science.gov (United States)

... shareware for population genetic analysis. Molecular Biology and Biotecnology Centre, Univ. of Alberta, Canada. enlarge figure Fig. ... ...

Energy Technology Data Exchange (ETDEWEB)

Low temperature Nonphotochemical Hole Burning (NPHB) Spectroscopy of the dye rhodamine 800 (MF680) was applied for the purpose of discerning differences between cultured normal and carcinoma ovarian surface epithelial (OSE) cells. Both the cell lines were developed and characterized at the Mayo Clinic (Rochester, MN), with the normal cell line having been transfected with a strain of temperature sensitive Simian Virus 40 Large T Antigen (SV40) for the purpose of extending the life of the cell culture without inducing permanent changes in the characteristics of the cell line. The cationic lipophilic fluorophore rhodamine 800 preferentially locates in in situ mitochondria due to the high lipid composition of mitochondria and the generation of a large negative membrane potential (relative to the cellular cytoplasm) for oxidative phosphorylation. Results presented for NPHB of MF680 located in the cells show significant differences between the two cell lines. The ...

International Nuclear Information System (INIS)

There are very different views on the health hazards of DU munitions. Most of the concerns of veterans and their advisors focus on the radiological effects of DU and consequently these are the focus of this editorial. Effects on the kidney and environmental consequences are, however, considered in the second of the Royal Society reports and the main conclusions of both of the reports are outlined in the summary document published in this issue of the journal. The main radiological concerns focus on the irradiation of lung tissues from inhaled DU particles and irradiation resulting from the translocation of inhaled particles to the thoracic lymph nodes.The overwhelming scientific view, presented in the two Royal Society reports and in other independent reviews, is that the main risks of exposure to DU aerosols are an increase in lung cancer and (from chemical toxicity) damage to the kidney, although these are likely to be evident only following substantial intakes. The equivalent doses ...

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Short communication. 5 refs., 2 figs.

KoreaScience (Korea)

Full Text Available

International Nuclear Information System (INIS)

Short communications only.

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

International Nuclear Information System (INIS)

... Mohamed, MM Medical Research Institute (Egypt) Ghatass, ZF Institute of

Energy Technology Data Exchange (ETDEWEB)

Four techniques for using LIDAR in Search and Rescue Operations will be discussed. The topic will include laser retroreflection, laser-induced fluorescence in the visible, laser-induced fluorescence during daylight hours, and laser-induced fluorescence in the uv. These techniques use high-repetition rate lasers at a variety of frequencies to induce either fluorescence in dye markers or retroreflection from plastic corner cubes on life preservers and other emergency markers.

UK PubMed Central (United Kingdom)

Stem-boring insects and methyl jasmonate (MeJA) are thought to induce similar complex chemical and anatomical defenses in conifers. To compare insect- and MeJA-induced terpenoid responses, we analyzed...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared.

KoreaScience (Korea)

Full Text Available

Energy Technology Data Exchange (ETDEWEB)

No abstract prepared

International Nuclear Information System (INIS)

Short communication.

KoreaScience (Korea)

Full Text Available

KoreaScience (Korea)

Full Text Available

J-STORE (Japan)

Full Text Available

KoreaScience (Korea)

Full Text Available

International Nuclear Information System (INIS)

The Ra, Th, and K-40 content of the most important phosphate fertilizers used and authorized in the FRG was determined by #gamma#-spectroscopy. The results, together with statistical data on the consumption and use of fertilizers, were used for an estimation of the contribution of #gamma#-radiation from phosphate fertilizers to the external population exposure in the FRG. (orig./AK).

International Nuclear Information System (INIS)

The consumption of food products obtained in areas subjected to radioactive contamination as a consequence of a radiation accident appears to be the most significant source of irradiation for the population. At the same time, this route can be regulated very effectively. The regularities of contamination of agricultural production, peculiar features of internal dose formation in the population and the effectiveness of countermeasures in agriculture have been analysed using the experience of two major accidents in the former USSR - in the South Urals (Kyshtym accident) in 1957, and at the Chernobyl NPP in 1986. (Author).

Energy Technology Data Exchange (ETDEWEB)

This report revises estimates of population exposure to external natural background made by D. T. Oakley in 1972. The revisions include more recent estimates of dose equivalents from cosmic rays, use of 1970 U.S. census data, and corrections for building shielding and for self-shielding in the body. The dose equivalents calculated are those from cosmic rays and terrestrial radiation, and do not include doses from natural radioactive materials in the body.

Energy Technology Data Exchange (ETDEWEB)

It is shown that observations of the lithium isotope ratio in high surface temperature Population II stars may be critical to cosmological nucleosynthesis models. In particular, decaying particle scenarios as derived in some supersymmetric models may stand or fall with such observations. 18 references.

Science.gov (United States)

The theoretical evolution of a horizontal branch star of Population II is followed through the helium burning in the core phase and is compared with the results given by other investigators. The m- fluence of different physics and interpolation schemes in the opacity tables is discussed. Some thoughts are given on the explanation of the erratic period variations observed in some of the RR Lyrae variables in the globular clusters. (auth)

Energy Technology Data Exchange (ETDEWEB)

Discussion is presented of world CO{sub 2} emissions and the effect rising population and population distribution has on this. Possible ways of decreasing emissions are presented, including potential for heat recovery, exhaust-air purification as an energy supply, shared power supply in industry, the use of cogeneration, and multiple use of heat in industry. 9 refs., 10 figs., 3 tabs.

UK PubMed Central (United Kingdom)

Using QCT, we made a longitudinal, population-based assessment of rates of bone loss over life at the distal radius, distal tibia, and lumbar spine. Cortical bone loss began in perimenopause in women...Full Text Available

International Nuclear Information System (INIS)

The authors review two types of simulators for the analysis of cosmic ray neutron-induced soft errors (SE's). One of them is the neutron-induced soft error simulator (NISES). A recently proposed nuclear reaction theory forms the foundation for the nuclear reaction database used in NISES. The other simulator, the simplified simulator MBGR, is based on a modified version of the burst generation rate (BGR) model. Both simulators accurately simulate neutron-induced SE rates (SER's). MBGR actually provides an easier and quicker estimation of neutron-induced SER's than NISES. On the other hand, NISES covers more applications; it simulates neutron-induced charge collection, multiple-bit SE, and #alpha#-induced SE analysis

International Nuclear Information System (INIS)

A computerised glow curve deconvolution (CGCD) analysis was applied to the main dosimetric peak of #alpha#-Al_2O_3:C in order to study the effects of light on the glow curve shape. It was shown that both the light-induced signal and the light-induced fading effects tend to shift the main dosimetric peak to higher temperatures and at the same time change its shape. Furthermore it was confirmed that the magnitude of the light-induced signal depends on radiation history and, by increasing the duration of light exposure, the magnitude of the light-induced signal reaches a plateau, thereby implying the saturation of the phototransfer process. (author).

International Nuclear Information System (INIS)

Female rats were given tritiated drinking water (3 microCi/ml) from 30 days before mating up to and throughout pregnancy. At this low dose, the course and the outcome of pregnancy were normal. The differences between newborn body and cerebral weights of the treated rats and those of control animals were on the borderline of significance. In contrast, cerebral DNA and cerebral protein were highly significantly lower. In 30-35% of the treated population the DNA and protein values were more than 2 standard deviations (SD) below the mean values for the control population. Thus the number of the progeny of the mothers exposed to tritiated water that were considered to have outstandingly low levels of DNA and protein was 14-17 times greater than in the control group. The irradiated population also had 3-5% of severely affected individuals with cerebral DNA and protein values more than 2 SD below the mean of the experimental ...

Science.gov (United States)

In this article, we propose a model selection method, the Bayesian composite model space approach, to map quantitative trait loci (QTL) in a half-sib population for continuous and binary traits. In our method, the identity-by-descent-based variance component model is used. To demonstrate the performance of this model, the method was applied to map QTL underlying production traits on BTA6 in a Chinese half-sib dairy cattle population. A total of four QTLs were detected, whereas only one QTL was identified using the traditional least square (LS) method. We also conducted two simulation experiments to validate the efficiency of our method. The results suggest that the proposed method based on a multiple-QTL model is efficient in mapping multiple QTL for an outbred half-sib population and is more powerful than the LS method based on a single-QTL model. PMID:21487433

British Library Electronic Table of Contents (United Kingdom)

Phenotypic plasticity can facilitate reproductive strategies that maximize mating success in variable environments and lead to differences in sex allocation among populations. For simultaneous hermaphrodites with sperm competition, including Serranus tortugarum a small coral reef fish, proportional male allocation (testis in total gonad) is often greater where local density or mating group size is higher. We tested whether S. tortugarum reduced male allocation when transplanted from a higher density site to a lower density site. After 4?months, transplants mirrored the sex-allocation patterns of the resident population on their new reef. Transplants had significantly lower male allocation than representatives from their source population, largely as a result of reduced testis mass relative...

British Library Electronic Table of Contents (United Kingdom)

Monocelis lineata is a complex of cryptic species (three in the Mediterranean and one in the Atlantic) widespread in midlittoral habitats. Throughout the range, populations with or without an ocular pigmented shield are found. We investigated the genetic structure of the North-East Atlantic populations with the aim of shedding light on their phylogeography and reconstructing possible patterns of recolonization after the Wrmian glaciation. Fourteen samples were investigated using cytochrome c oxidase subunit I (COI) and 13 by inter-simple sequence repeats (ISSRs). COI did not exhibit a clear pattern of decreased genetic diversity along a latitudinal gradient. Populations from Ferrol (Spain), Doolin (Ireland), and Helsingr (Denmark) showed a higher genetic variability, whereas a reduction in...

British Library Electronic Table of Contents (United Kingdom)

Despite the many advances in scientific research over the last several decades, cutting edge technologies and therapeutics often take many years to find their way into widespread use. The dissemination and uptake of best practices into clinical care is sometimes a neglected component of research that is essential to improve the population?s health. Type 2 translational research, sometimes called ?Proof in Practice Research,? seeks to maximize the yield of what has been learned from the bench and from carefully controlled clinical trials and to extend those benefits to a larger population. One aspect of type 2 translational research, sometimes called evidence implementation or implementation science, applies what has been learned about clinical medicine to achieve best practices across prov...

Energy Technology Data Exchange (ETDEWEB)

ExternE is a pan{sub E}uropean project aimed at identifying and quantifying external effects from different energy production technologies around Europe. The Swedish implementation carried out case studies on a biomass plant, a coal plant and a hydro power plant. The conventional approach within the ExternE project is to estimate impacts for each priority pathway associated with the fuel cycle, and then economic methods to obtain estimates for the economic damage of each particular impact pathway. However, in the case of hydro power, it is generally not possible to estimate the most important impacts quantitatively. Therefore, a contingent valuation (CV) study was initiated. In a typical CV-study, a selection of individuals are asked to state their willingness to pay for a certain environmental improvement or to avoid an environmental damage. Welfare economic theory suggests that the well-being effects on people from a change from one situation to another can be measured as their ...

International Nuclear Information System (INIS)

Interleukin 2 (IL-2) is a T-cell-derived lymphokine critical in the activation and proliferation of T cells, B cells, and lymphokine-activated killer cells. It is a glycoprotein of #approx#15,500 daltons that is synthesized and secreted after activation by antigen or mitogen. By using the analogs 8-azidoadensoine 5'-[#gamma#-"3"2P]triphosphate ([#gamma#-"3"2P]8N_3ATP) and nicotinamide 2-azidoadenine [adenylate-"3"2P]dinucleotide ([#alpha#-"3"2P]2N_3NAD"+) as photoaffinity probes, the authors have detected specific, metal ion-requiring nucleotide binding sites on recombinant human IL-2 (rhIL-2). The specificity of these nucleotide interactions with rhIL-2 was demonstrated by saturation effects and by competition by the parent nucleotides at physiologically relevant concentrations. Saturation of photoinsertion into rhIL-2 occurred at 50 #mu#M [#gamma#-"3"2P]8N_3ATP. Saturation of photoinsertion with [#alpha#-"3"2P]2N_3NAD"+ was observed at 180 ...

Energy Technology Data Exchange (ETDEWEB)

The DNA sequence motif ATTTGCAT (octamer) or its inverse complement has been identified as an evolutionarily conserved element in the promoter region of immunoglobulin genes. Two major DNA-binding proteins that bind in a sequence-specific manner to the octamer DNA sequence have been identified in mammalian species--a ubiquitously expressed protein (Oct-1) and a lymphoid-specific protein (Oct-2). During characterization of the promoter region of the chicken immunoglobulin light chain gene, the authors identified two homologous octamer-binding proteins in chicken B cells. when the cloning of the human gene for Oct-2 revealed it to be a member of a distinct family of homeobox genes, they sought to determine if the human Oct-2 cDNA could be used to identify homologous chicken homeobox genes. Using a human Oct-2 homeobox-specific DNA probe, they were able to identify 6-10 homeobox-containing genes in the chicken genome, demonstrating that the ...

UK PubMed Central (United Kingdom)

Global acetylation of histone H4 is a mark of gene transcriptional activation. The c-Myc transcription factor binds to specific DNA sites in cellular chromatin and induces the acetylation of...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundWe examined the effects of short-term consumption of whey protein isolate on muscle proteins and force recovery after eccentrically-induced muscle damage in healthy individuals.MethodsSeventeen...Full Text Available

UK PubMed Central (United Kingdom)

Hypoxia inducible factor-1 (HIF-1) promotes tumor cell adaptation to microenvironmental stress. HIF-1 is up-regulated in irradiated tumors and serves as a promising target for radiosensitization....Full Text Available

UK PubMed Central (United Kingdom)

The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7 ± 3.7)...Full Text Available

UK PubMed Central (United Kingdom)

An ultrasensitive laser-induced fluorescence detector was used with capillary electrophoresis for the study of 5-carboxy-tetramethylrhodamine. The raw signal from the detector provided roughly...Full Text Available

UK PubMed Central (United Kingdom)

It has been observed that puncture of a lumbar disc may induce formation of a nodule on the surface of the disc and osteophytes. It is not known if this is based on the presence of a foreign tissue...Full Text Available

UK PubMed Central (United Kingdom)

The morphogenesis of pulmonary edema and bronchiolar injury induced by the toxic furan, 4-ipomeanol, was studied by combined light and transmission electron microscopy. Weanling male CD-1 mice received...Full Text Available

UK PubMed Central (United Kingdom)

Petal senescence, one type of programmed cell death (PCD) in plants, is a genetically controlled sequence of events comprising its final developmental stage. We characterized the pollination-induced...Full Text Available

Energy Technology Data Exchange (ETDEWEB)

Treatment of Japanese pines (P. densiflora and P. thunbergii) with paraquat induced a zone of lightwood. Determinations of turpentine and ether extractives contents in lightwoods showed high levels as compared with those in control woods. (Refs. 5).

International Nuclear Information System (INIS)

The measured result of charged multiplicity in cosmic-ray proton induced nuclear reaction from Chinese satellite emulsion is reported. The correlation of shower and heavy particles is discussed and compared with p-emulsion interactions.

UK PubMed Central (United Kingdom)

The goal of this study was to determine if the exaggerated morphine-induced conditioned place preference (CPP) response seen in adult rats after preweanling methylphenidate exposure is unique...Full Text Available

UK PubMed Central (United Kingdom)

The mechanism of chemotherapy-induced acceleration of ovarian aging is not fully understood. We used doxorubicin, a widely used cancer chemotherapeutic, in a variety of in vivo xenograft,...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundSome breast cancer patients receiving anti-angiogenic treatment show increased metastases, possibly as a result of induced hypoxia. The effect of hypoxia on tumor cell...Full Text Available

UK PubMed Central (United Kingdom)

Reversion-induced LIM protein (RIL) is a member of the ALP (actinin-associated LIM protein) subfamily of the PDZ/LIM protein family. RIL serves as an adaptor protein and seems to regulate cytoskeletons....Full Text Available

UK PubMed Central (United Kingdom)

Increased sensitivity to light-induced melatonin suppression characterizes some, but not all, patients with bipolar illness or seasonal affective disorder. The aim of this study was to test...Full Text Available

UK PubMed Central (United Kingdom)

Calorie restriction (CR) induces a metabolic shift towards mitochondrial respiration; however, molecular mechanisms underlying CR remain unclear. Recent studies suggest that CR-induced mitochondrial...Full Text Available

UK PubMed Central (United Kingdom)

Heat shock proteins (Hsp) are a family of stress-inducible molecular chaperones that play multiple roles in a wide variety of animals. However, the roles of Hsps in parasitic nematodes remain largely...Full Text Available

UK PubMed Central (United Kingdom)

Accumulation of molecular damage and increased molecular heterogeneity are hallmarks of cellular aging. Mild stress-induced hormesis can be an effective way for reducing the accumulation of molecular...Full Text Available

UK PubMed Central (United Kingdom)

Cigarette smoke (CS) induces recruitment of inflammatory cells in the lungs leading to the generation of reactive oxygen species (ROS), which are involved in lung inflammation and injury. Nicotinamide...Full Text Available

UK PubMed Central (United Kingdom)

The speed of ethylene-induced leaf abscission in cotton (Gossypium hirsutum L. cv LG-102) seedlings is dependent on leaf position (i.e. physiological age). Fumigation...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundTrichloroethylene (TCE) may induce oxidative stress which generates free radicals and alters antioxidants or oxygen-free radical scavenging enzymes.MethodsTwenty...Full Text Available

UK PubMed Central (United Kingdom)

Systemic administration of lipopolysaccharide (LPS), which causes endotoxemia and systemic inflammation, has been reported to induce expression of the gene for type II inducible nitric oxide synthase...Full Text Available

UK PubMed Central (United Kingdom)

Explants from flower stalks of Nicotiana tabacum L. were cultured on different cytokinins to induce flower bud formation. All cytokinins tested except zeatin and zeatin-riboside induced...Full Text Available

UK PubMed Central (United Kingdom)

Rationale: Ventilator-induced lung injury (VILI) leads to an unacceptably high mortality. In this regard, the antiinflammatory properties of inhaled carbon monoxide (CO) may provide...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVES—To investigate the relation between different types of exposure to noise and a classic sign of noise induced hearing loss (NIHL), the audiometric notch.
METHODS—The...Full Text Available

UK PubMed Central (United Kingdom)

Fatalities caused by parasitic infections often occur as a result of tissue injury that results from a form of host-cell death known as apoptosis. However, instead of being pathogenic, parasite-induced...Full Text Available

UK PubMed Central (United Kingdom)

The aim of the present study was to evaluate the ameliorative potential of quercetin (QC) against paracetamol (PCM)-induced oxidative stress and biochemical alterations in mice blood. A total of 36...Full Text Available

UK PubMed Central (United Kingdom)

Hundreds of thousands of people worldwide live or work in close proximity to steel mills. Integrated steel production generates chemical pollution containing compounds that can induce genetic damage...Full Text Available

UK PubMed Central (United Kingdom)

During sexual development, Neurospora crassa inactivates genes in duplicated DNA segments by a hypermutation process, repeat-induced point mutation (RIP). RIP introduces C:G to T:A...Full Text Available

International Nuclear Information System (INIS)

Purpose/Objective: The role of programmed cell death (apoptosis) as a cellular response to cancer therapy such as radiation or chemotherapy is the subject of much study, and manipulation of the apoptotic response in tumor cells may be valuable in the treatment of a variety of cancers. Both p53 dependent and independent apoptotic pathways have been identified; p53 is mutated in at least 50 % of human cancers and a majority of radiation resistant tumors contain p53 mutations. This study is designed to examine the induction of programmed cell death in a human colon carcinoma cell line that possesses two mutated p53 alleles. Ionizing radiation alone, or in combination with the chemotherapeutic drug 5-fluorouracil (5-FU), were used to elicit the apoptotic response. This study will focus on whether these treatments can induce a significant apoptotic response in cells that have mutated p53 alleles. Materials and Methods: HT-29 cells were assessed for clonogenic survival ...

UK PubMed Central (United Kingdom)

To evaluate the role of chronic inflammation in the development of gallstones and biliary tract cancer, we examined the risk associated with 62 single nucleotide polymorphisms (SNPs), including...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundExisting studies concerning the health care use of homeless people describe higher utilisation rates for hospital-based care and emergency care, and lower rates for primary...Full Text Available

UK PubMed Central (United Kingdom)

Ecological investigations were made of habitats containing natural populations of the snail Oncomelania hupensis quadrasi and of habitats free from the snail in the island of Leyte,...Full Text Available

UK PubMed Central (United Kingdom)

OBJECTIVE--To assess the accuracy of the ten questions screen as a measure of childhood disability for epidemiologic studies in populations lacking resources for professional assessment of children's...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundThe aim of the study was to examine the role that melatonin production plays in the regulation of sleep consolidation in a population of shiftworkers working and sleeping...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundDuring the last ten years, major advances have been made in characterizing and understanding the evolution of mitochondrial DNA, the most popular marker of molecular biodiversity....Full Text Available

UK PubMed Central (United Kingdom)

Most of the general population is exposed to carbaryl and other contemporary-use insecticides at low levels. Studies of laboratory animals, in addition to limited human data, show an association between...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundEpidemiological studies have shown a J- or U-shaped relation between alcohol and type 2 diabetes and coronary heart disease (CHD). The underlying mechanisms are not clear....Full Text Available

UK PubMed Central (United Kingdom)

Background. For unknown reasons, the prevalence of thyroid autoimmune disorders is higher in patients with Down's syndrome than in the general population. The present case strongly...Full Text Available

UK PubMed Central (United Kingdom)

High blood pressure (BP) is a major public health problem in India and its prevalence is rapidly increasing among urban and rural populations. Reducing systolic and diastolic BP can decrease cardiovascular...Full Text Available

UK PubMed Central (United Kingdom)

Objectives: To determine the community based prevalence of rheumatic heart disease (RHD) in the rural population of the district of Rahim Yaar Khan in Pakistan.Subjects...Full Text Available

UK PubMed Central (United Kingdom)

BackgroundPrevention of Chagas disease depends mainly on control of the insect vectors that transmit infection. Unfortunately, the vectors have been resurgent in some areas. It is...Full Text Available

International Nuclear Information System (INIS)

The somatically significant dose index can be considered as a measure for the somatic radiation risk to which the population is exposed. Figures are stated for conventional tomography of the skull and thorax. These are compared with the corresponding data for other X-ray examinations, especially computerised tomography. (orig.).

UK PubMed Central (United Kingdom)

Dental caries continues to be a common chronic disease among various population groups. Patient care can be improved with detection at the earliest stage. However, current techniques do not...Full Text Available

Science.gov (United States)

Project ZEUS was designed to characterize the effects of long-term gamma irradiation on free-ranging meadow voles, and to determine the lowest level of radiation at which biological effects are discernible in the population. Behavioural tests are consider...

UK PubMed Central (United Kingdom)

PurposeNocturnal rhythms of gene expression in the retina are known to be both darkness- and circadian clock-dependent, but their role and cellular location are not well defined....Full Text Available

UK PubMed Central (United Kingdom)

Quality reporting tools, integrated with ambulatory electronic health records, can help clinicians and administrators understand performance, manage populations, and improve quality. Report Central...Full Text Available