Sample records for axis vegf-flt-1 fms-like

  1. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia.

    Burke, Suzanne D; Zsengellér, Zsuzsanna K; Khankin, Eliyahu V; Lo, Agnes S; Rajakumar, Augustine; DuPont, Jennifer J; McCurley, Amy; Moss, Mary E; Zhang, Dongsheng; Clark, Christopher D; Wang, Alice; Seely, Ellen W; Kang, Peter M; Stillman, Isaac E; Jaffe, Iris Z; Karumanchi, S Ananth


    Preeclampsia is a hypertensive disorder of pregnancy in which patients develop profound sensitivity to vasopressors, such as angiotensin II, and is associated with substantial morbidity for the mother and fetus. Enhanced vasoconstrictor sensitivity and elevations in soluble fms-like tyrosine kinase 1 (sFLT1), a circulating antiangiogenic protein, precede clinical signs and symptoms of preeclampsia. Here, we report that overexpression of sFlt1 in pregnant mice induced angiotensin II sensitivity and hypertension by impairing endothelial nitric oxide synthase (eNOS) phosphorylation and promoting oxidative stress in the vasculature. Administration of the NOS inhibitor l-NAME to pregnant mice recapitulated the angiotensin sensitivity and oxidative stress observed with sFlt1 overexpression. Sildenafil, an FDA-approved phosphodiesterase 5 inhibitor that enhances NO signaling, reversed sFlt1-induced hypertension and angiotensin II sensitivity in the preeclampsia mouse model. Sildenafil treatment also improved uterine blood flow, decreased uterine vascular resistance, and improved fetal weights in comparison with untreated sFlt1-expressing mice. Finally, sFLT1 protein expression inversely correlated with reductions in eNOS phosphorylation in placental tissue of human preeclampsia patients. These data support the concept that endothelial dysfunction due to high circulating sFLT1 may be the primary event leading to enhanced vasoconstrictor sensitivity that is characteristic of preeclampsia and suggest that targeting sFLT1-induced pathways may be an avenue for treating preeclampsia and improving fetal outcomes. PMID:27270170

  2. FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis.

    Joanna R Ghali

    Full Text Available Fms-like tyrosine kinase 3-ligand (FL is a growth factor that may expand dendritic cell and regulatory T cell populations. We hypothesised that FL-induced regulatory T cells would protect mice from experimental rapidly progressive glomerulonephritis. To determine if FL was able to enhance regulatory T cell populations, C57BL/6 mice received 10 days of daily intraperitoneal injections of either FL or phosphate buffered saline. To induce accelerated autologous-phase anti-mouse glomerular basement membrane glomerulonephritis, mice were sensitized to sheep globulin 4 days prior to the induction of glomerulonephritis with sheep anti-mouse glomerular basement membrane globulin, and experiments ended 10 days later. FL was administered before, throughout and during the sensitization phase of this glomerulonephritis model. Renal disease and systemic immunity to the nephritogenic antigen were assessed. FL increased regulatory T cell and plasmacytoid dendritic cell proportions within spleen and lymph nodes. FL administration prior to glomerulonephritis did not protect mice from renal injury. When FL was given throughout the model, FL treated mice had reduced survival, with more interstitial neutrophils and glomerular CD11c+ cells than controls. Systemic immune responses showed increased IL-17A production from splenocytes, with more CD11c+ cells, but reduced plasmacytoid dendritic cell proportions in spleen and lymph nodes, despite increased regulatory T cell proportions. Under homeostatic conditions, FL expanded regulatory T cell and plasmacytoid dendritic cell populations, but FL enhanced systemic inflammatory responses and conventional dendritic cell populations when given during experimental glomerulonephritis, suggesting selective attempts to suppress pathogenic immunity by dendritic cell manipulation may be harmful.

  3. Fms-like tyrosine kinase-3 ligand alters antigen-specific responses to infections after severe burn injury

    Bohannon, Julia; Fang, Geping; Cui, Weihua; Sherwood, Edward; Toliver-Kinsky, Tracy


    Burn patients are susceptible to opportunistic infections due partly to decreased immune functions, especially Th1-driven antigen-specific responses, which are regulated by dendritic cells. The dendritic cell growth factor, fms-like tyrosine kinase-3 ligand (FL), has been shown to increase resistance to P. aeruginosa, in a dendritic cell-dependent manner, in a mouse model of burn wound infection. The specific mechanisms of protection are not known. This study tested the hypothesis that FL can...

  4. Glyceryl Trinitrate Inhibits Hypoxia-Induced Release of Soluble fms-Like Tyrosine Kinase-1 and Endoglin from Placental Tissues

    BARSOUM, IVRAYM B.; Renaud, Stephen J.; Graham, Charles H.


    Preeclampsia is associated with increased circulating levels of proinflammatory molecules, such as soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng). On release by an inadequately perfused placenta into the maternal circulation, these molecules cause systemic endothelial dysfunction and the associated hypertension and proteinuria that characterize preeclampsia. We previously showed that glyceryl trinitrate (GTN) inhibits hypoxia/reoxygenation-induced apoptosis in the syn...

  5. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.

    Kaipainen, A; Korhonen, J; Mustonen, T; van Hinsbergh, V W; G. H. Fang; Dumont, D,; Breitman, M; Alitalo, K


    We have recently cloned the human fms-like tyrosine kinase 4 gene FLT4, whose protein product is related to two vascular endothelial growth factor receptors FLT1 and KDR/FLK1. Here the expression of FLT4 has been analyzed by in situ hybridization during mouse embryogenesis and in adult human tissues. The FLT4 mRNA signals first became detectable in the angioblasts of head mesenchyme, the cardinal vein, and extraembryonally in the allantois of 8.5-day postcoitus (p.c.) embryos. In 12.5-day p.c...

  6. Clonal evolution of AML on novel FMS-like tyrosine kinase-3 (FLT3 inhibitor therapy with evolving actionable targets

    Pashtoon M. Kasi


    Full Text Available For acute myeloid leukemia (AML, identification of activating mutations in the FMS-like tyrosine kinase-3 (FLT3 has led to the development of several FLT3-inhibitors. Here we present clinical and next generation sequencing data at the time of progression of a patient on a novel FLT3-inhibitor clinical trial (ASP2215 to show that employing therapeutic interventions with these novel targeted therapies can lead to consequences secondary to selective pressure and clonal evolution of cancer. We describe novel findings alongside data on treatment directed towards actionable aberrations acquired during the process. (Clinical Trial: NCT02014558; registered at: 〈〉

  7. Maternal soluble fms-like tyrosine kinase-1, placental growth factor, plasminogen activator inhibitor-2, and folate concentrations and early fetal size : the Generation R study

    Bouwland-Both, Marieke I.; Steegers, Eric A. P.; Lindemans, Jan; Russcher, Henk; Hofman, Albert; Geurts-Moespot, Anneke J.; Sweep, Fred C. G. J.; Jaddoe, Vincent W. V.; Steegers-Theunissen, Regine P. M.


    OBJECTIVE: Fetal growth is dependent on adequate development of the placenta. Impaired angiogenesis and vasculogenesis in early pregnancy compromises placental and embryonic development. The proteins soluble fms-like tyrosine kinase (sFlt)-1, placental growth factor (PlGF), and plasminogen activator

  8. Increased serum levels of anti-angiogenic factors soluble fms-like tyrosine kinase and soluble endoglin in sickle cell disease

    Landburg, P P; Elsenga, H; Schnog, J B; Duits, A J


    The anti-angiogenic factors soluble fms-like tyrosine kinase (sFlt)-1 and soluble endoglin (sEng) have been shown to be of importance in angiogenesis by sequestering and inhibiting vascular endothelial growth factor, placenta-like growth factor and transforming growth factor-beta(1) signaling. Given

  9. Suppressed Production of Soluble Fms-Like Tyrosine Kinase-1 Contributes to Myocardial Remodeling and Heart Failure.

    Seno, Ayako; Takeda, Yukiji; Matsui, Masaru; Okuda, Aya; Nakano, Tomoya; Nakada, Yasuki; Kumazawa, Takuya; Nakagawa, Hitoshi; Nishida, Taku; Onoue, Kenji; Somekawa, Satoshi; Watanabe, Makoto; Kawata, Hiroyuki; Kawakami, Rika; Okura, Hiroyuki; Uemura, Shiro; Saito, Yoshihiko


    Soluble fms-like tyrosine kinase-1 (sFlt-1), an endogenous inhibitor of vascular endothelial growth factor and placental growth factor, is involved in the pathogenesis of cardiovascular disease. However, the significance of sFlt-1 in heart failure has not been fully elucidated. We found that sFlt-1 is decreased in renal failure and serves as a key molecule in atherosclerosis. In this study, we aimed to investigate the role of the decreased sFlt-1 production in heart failure, using sFlt-1 knockout mice. sFlt-1 knockout mice and wild-type mice were subjected to transverse aortic constriction and evaluated after 7 days. The sFlt-1 knockout mice had significantly higher mortality (52% versus 15%; P=0.0002) attributable to heart failure and showed greater cardiac hypertrophy (heart weight to body weight ratio, 8.95±0.45 mg/g in sFlt-1 knockout mice versus 6.60±0.32 mg/g in wild-type mice; Pfailure through upregulation of monocyte chemoattractant protein-1 expression in pressure-overloaded heart. PMID:27480835

  10. In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (FLT3) ligand in hematopoietic development.

    Tsapogas, Panagiotis; Swee, Lee Kim; Nusser, Anja; Nuber, Natko; Kreuzaler, Matthias; Capoferri, Giuseppina; Rolink, Hannie; Ceredig, Rhodri; Rolink, Antonius


    Cytokines are essential regulators of hematopoiesis, acting in an instructive or permissive way. Fms-like tyrosine kinase 3 ligand (FLT3L) is an important cytokine for the development of several hematopoietic populations. Its receptor (FLT3) is expressed on both myeloid and lymphoid progenitors and deletion of either the receptor or its ligand leads to defective developmental potential of hematopoietic progenitors. In vivo administration of FLT3L promotes expansion of progenitors with combined myeloid and lymphoid potential. To investigate further the role of this cytokine in hematopoietic development, we generated transgenic mice expressing high levels of human FLT3L. These transgenic mice displayed a dramatic expansion of dendritic and myeloid cells, leading to splenomegaly and blood leukocytosis. Bone marrow myeloid and lymphoid progenitors were significantly increased in numbers but retained their developmental potential. Furthermore, the transgenic mice developed anemia together with a reduction in platelet numbers. FLT3L was shown to rapidly reduce the earliest erythroid progenitors when injected into wild-type mice, indicating a direct negative role of the cytokine on erythropoiesis. We conclude that FLT3L acts on multipotent progenitors in an instructive way, inducing their development into myeloid/lymphoid lineages while suppressing their megakaryocyte/erythrocyte potential. PMID:24463214

  11. Fms-like Tyrosine Kinase (FLT) 3 and FLT3 Internal Tandem Duplication in Different Types of Adult Leukemia: Analysis of 147 Patients

    Peng, Hong-ling; Zhang, Guang-Sen; Gong, Fan-Jie; Shen, Jian-Kai; Zhang, Yang; Xu, Yun-Xiao; Zheng, Wen-Li; Dai, Chong-Wen; Pei, Min-Fei; YANG, JUN-JIE


    Aim To assess the expression level of fms-like tyrosine kinase 3 (FLT3), the incidence of FLT3/internal tandem duplications (ITD) mutation, and prognostic value of FLT3 changes in different types of adult leukemia. Methods Bone marrow mononuclear cells were isolated from 147 adult patients with leukemia. Reverse transcriptase polymerase chain reaction (PCR) was used to screen FLT3/ITD mutation and quantitative PCR was performed to evaluate the expression of the FLT3 transcri...

  12. Murine germinal center B cells require functional Fms-like tyrosine kinase 3 signaling for IgG1 class-switch recombination.

    Svensson, Mattias N D; Andersson, Karin M E; Wasén, Caroline; Erlandsson, Malin C; Nurkkala-Karlsson, Merja; Jonsson, Ing-Marie; Brisslert, Mikael; Bemark, Mats; Bokarewa, Maria I


    Switched antibody classes are important for efficient immune responses. Aberrant antibody production to otherwise harmless antigens may result in autoimmunity. The protein kinase fms-like tyrosine kinase 3 receptor (Flt3) has an important role during early B-cell development, but the role of Flt3 in peripheral B cells has not been assessed before. Herein we describe a previously unappreciated role for Flt3 in IgG1 class-switch recombination (CSR) and production. We show that Flt3 is reexpressed on B-cell lymphoma 6(+) germinal center B cells in vivo and following LPS activation of peripheral B cells in vitro. Absence of Flt3 signaling in Flt3 ligand-deficient mice results in impaired IgG1 CSR and accumulation of IgM-secreting plasma cells. On activated B cells, Flt3 is coexpressed and functions in synergy with the common-gamma chain receptor family. B cells from Flt3 ligand-deficient mice have impaired IL-4R signaling, with reduced phosphorylation of signal transducer and activator of transcription (Stat) 6, and demonstrate a failure to initiate CSR to IgG1 with low expression of γ1 germ-line transcripts, resulting in impaired IgG1 production. Thus, functional synergy between Flt3 and IL-4R signaling is critical for Stat-mediated regulation of sterile γ1 germ-line transcripts and CSR to IgG1. PMID:26627255

  13. Soluble fms-like tyrosine kinase-1 and vascular endothelial growth factor:Novel markers for unexplained early recurrent pregnancy loss

    Mahmoud Fathy; Hassan


    Objective:To evaluate the role of soluble fms-like tyrosine kinase-1(sFlt-1) and vascular endothelial growth factor(VEGF) for prediction of pregnancy loss in patients with history of unexplained early recurrent pregnancy loss(RPL).Methods:A prospective case control study was conducted in42 women with history of unexplained earlyRPL, and170 pregnant controls with history of uncomplicated pregnancy.We measured maternal serum sFlt-1 andVEGF at gestational age6-9 weeks as predictor for pregnancy loss.Results:Mean serum levels of sFlt-1 andVEGF were significantly higher inRPL group than controls(10439.7±385.4vs3304.5±104.8;P<0.0001, for sFlt-1, and1885.0±98.3 vs709.8±24.8;P<0.0001, forVEGF).Receiver operating characteristic(ROC) curves analyses established that sFlt-1 andVEGF were able to discriminate women at risk of developing pregnancy loss with area underROC curve0.970 for sFlt-1 and0.953 forVEGF.Cutoff value of5159.5 pg/mL for sFlt-1 was predictor for early pregnancy loss with 95.2% sensitivity,91.2% specificity, and odds ratio(OR)206 [95%confidence interval(CI),45.4-941].Cutoff value of915.5 pg/mL forVEGF was predictor for early pregnancy loss with92.9% sensitivity,90.6% specificity, andOR125 [95%CI:34.7-451].Conclusion:These data advocate a relationship between sFlt-1,VEGF, andRPL suggesting that the high levels of sFlt-1 andVEGF might be associated with the pathogenesis ofRPL.

  14. Soluble fms-like tyrosine kinase-1 and endothelial adhesion molecules (intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1) as predictive markers for blood pressure reduction after renal sympathetic denervation.

    Dörr, Oliver; Liebetrau, Christoph; Möllmann, Helge; Gaede, Luise; Troidl, Christian; Rixe, Johannes; Hamm, Christian; Nef, Holger


    Renal sympathetic denervation (RSD) is a treatment option for patients with resistant arterial hypertension, but in some patients it is not successful. Predictive parameters on the success of RSD remain unknown. The angiogenic factors soluble fms-like tyrosine kinase-1 (sFLT-1), intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) are known to be associated with endothelial dysfunction, vascular remodeling, and hypertension. We evaluated whether sFLT-1, ICAM-1, and VCAM-1 are predictive markers for blood pressure reduction after RSD. Consecutive patients (n=55) undergoing renal denervation were included. Venous serum samples for measurement of sFlt-1, ICAM-1, and VCAM-1 were collected before and 6 months after RSD. A therapeutic response was defined as an office systolic blood pressure reduction of >10 mm Hg 6 months after RSD. A significant mean office systolic blood pressure reduction of 31.2 mm Hg was observed in 46 patients 6 months after RSD. Nine patients were classified as nonresponders, with a mean systolic blood pressure reduction of 4.6 mm Hg. At baseline, sFLT-1 levels were significantly higher in responders than in nonresponders (P<0.001) as were ICAM-1 (P<0.001) and VCAM-1 levels (P<0.01). The areas under the curve for sFLT-1, ICAM-1, and VCAM-1 were 0.82 (interquartile range, 0.718-0.921; P<0.001), 0.754 (0.654-0.854; P<0.001), and 0.684 (0.564-804; P=0.01), respectively, demonstrating prediction of an RSD response. Responders showed significantly higher serum levels of sFLT-1, ICAM-1, and VCAM-1 at baseline compared with nonresponders. Thus, this study identified for the first time potential biomarkers with a predictive value indicating a responder or nonresponder before renal denervation. PMID:24470464

  15. 补肾安胎冲剂对复发性流产患者血清血管内皮生长因子及其可溶性受体-1的影响%Effects of Granules for Tonifying Kidney and Preventing Miscarriage on Serum Levels of Vascular Endothelial Growth Factor and Soluble Fms-like Tyrosine Kinase-1 in Patients with Recurrent Spontaneous Abortion

    李伟莉; 胡瑞华


    目的 探讨补肾安胎冲剂治疗复发性流产(recurrent spontaneous abortion,RSA)的机制.方法 采用酶联免疫吸附法检测30例RSA患者治疗前后及30例正常早孕妇女血清血管内皮生长因子(vascular endothelial growth factor,VEGF)及其受体--可溶性fms样酪氨酸激酶-1(soluble fms-like tyrosine kinase-1,sFlt-1)的水平.结果 治疗组妊娠成功率为80.0%;与对照组比较,治疗组治疗前血清VEGF显著降低(P<0.01),sFlt-1显著增高(P<0.01);治疗组治疗后与治疗前比较,VEGF显著升高(P<0.01),sFlt-1显著降低(P<0.01);保胎治疗无效者与保胎治疗成功者比较,血清VEGF水平显著降低(P<0.01),血清sFlt-1水平显著增高(P<0.05).结论 补肾安胎冲剂治疗RSA的机制可能与提高血清VEGF水平,降低血清sFlt-1水平,从而促进胎盘绒毛血管的形成有关.%Objective To investigate the mechanism by -which Granules for tonifying the kidney and preventing miscarriage exert therapeutic effect in patients with recurrent spontaneous abortion (RSA). Methods Thirty RSA patients (as treatment group) and 30 women with normal early pregnancy (as control group) were included in this study. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum levels of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) before and after treatment with the granules for tonifying the kidney and preventing miscarriage. Results The success rate of pregnancy was 80. 00% in the treatment group. Before treatment, the treatment group had significantly lower serum VEGF level and significantly higher serum sFlt-1 level than the control group (P

  16. Diagnosis of preeclampsia with soluble Fms-like tyrosine kinase 1/placental growth factor ratio

    Andersen, Louise Bjørkholt; Frederiksen-Møller, Britta; Work Havelund, Kathrine;


    The angiogenic factor ratio soluble Fms-kinase 1 (sFlt-1)/placental growth factor (PlGF) is a novel diagnostic tool for preeclampsia. We compared the efficacy of the KRYPTOR (BRAHMS) automated assays for sFlt-1 and PlGF with the Elecsys (Roche) assays in a routine clinical setting. Preeclamptic...... women (n = 39) were included shortly after the time of diagnosis. Normotensive control pregnancies were matched by gestational age (n = 76). The KRYPTOR assays performed comparably or superior to Elecsys (sFlt-1/PlGF area under the curve 0.746 versus 0.735; P = .09; for non-obese 0.820 versus 0.805, P...... = .047). For early-onset preeclampsia, KRYPTOR area under the curve increased to 0.929 with a 100% specificity for preeclampsia at cut-off 85 and an 88.9% sensitivity for preeclampsia at cut-off 33. For women with preeclampsia and preterm delivery or Hemolysis, Elevated Liver enzymes, Low Platelet count...

  17. Triple axis spectrometers

    Conventional triple-axis neutron spectroscopy was developed by Brockhouse over thirty years ago' and remains today a versatile and powerful tool for probing the dynamics of condensed matter. The original design of the triple axis spectrometer is technically simple and probes momentum and energy space on a point-by-point basis. This ability to systematically probe the scattering function in a way which only requires a few angles to be moved under computer control and where the observed data in general can be analysed using a pencil and graph paper or a simple fitting routine, has been essential for the success of the method. These constraints were quite reasonable at the time the technique was developed. Advances in computer based data acquisition, neutron beam optics, and position sensitive area detectors have been gradually implemented on many triple axis spectrometer spectrometers, but the full potential of this has not been fully exploited yet. Further improvement in terms of efficiency (beyond point by point inspection) and increased sensitivity (use of focusing optics whenever the problem allows it) could easily be up to a factor of 10-20 over present instruments for many problems at a cost which is negligible compared to that of increasing the flux of the source. The real cost will be in complexity - finding the optimal set-up for a given scan and interpreting the data as the they are taken. On-line transformation of the data for an appropriate display in Q, ω space and analysis tools will be equally important for this task, and the success of these new ideas will crucially depend on how well we solve these problems. (author)

  18. Preferred axis in cosmology

    Zhao, Wen


    The foundation of modern cosmology relies on the so-called cosmological principle which states an homogeneous and isotropic distribution of matter in the universe on large scales. However, recent observations, such as the temperature anisotropy of the cosmic microwave background (CMB) radiation, the motion of galaxies in the universe, the polarization of quasars and the acceleration of the cosmic expansion, indicate preferred directions in the sky. If these directions have a cosmological origin, the cosmological principle would be violated, and modern cosmology should be reconsidered. In this paper, by considering the preferred axis in the CMB parity violation, we find that it coincides with the preferred axes in CMB quadrupole and CMB octopole, and they all align with the direction of the CMB kinematic dipole. In addition, the preferred directions in the velocity flows, quasar alignment, anisotropy of the cosmic acceleration, the handedness of spiral galaxies, and the angular distribution of the fine-structu...

  19. Three axis attitude control system

    Studer, Philip A. (Inventor)


    A three-axis attitude control system for an orbiting body comprised of a motor driven flywheel supported by a torque producing active magnetic bearing is described. Free rotation of the flywheel is provided about its central axis and together with limited angular torsional deflections of the flywheel about two orthogonal axes which are perpendicular to the central axis. The motor comprises an electronically commutated DC motor, while the magnetic bearing comprises a radially servoed permanent magnet biased magnetic bearing capable of producing cross-axis torques on the flywheel. Three body attitude sensors for pitch, yaw and roll generate respective command signals along three mutually orthogonal axes (x, y, z) which are coupled to circuit means for energizing a set of control coils for producing torques about two of the axes (x and y) and speed control of the flywheel about the third (z) axis. An energy recovery system, which is operative during motor deceleration, is also included which permits the use of a high-speed motor to perform effectively as a reactive wheel suspended in the magnetic bearing.

  20. Easy axis switching in magnetite

    The easy magnetic axis switching in magnetite is investigated. Magnetization data confirmed activation character of the process with activation energy of the same order as that of the Verwey transition, suggesting common origin. On the other hand this activation energy rises with pressure (up to 1.2GPa), unlike TV. The axis switching is clearly reflected in field dependence of resistivity and the direct structural data showed that it is simultaneous with the reorganization of structure. Thus, control of the structure can be possible with the application of magnetic field, as in shape memory materials. Finally, NMR showed that all, possibly decoupled entities: lattice distortion and charge and orbital orderings, change simultaneously while the axis switching occurs.

  1. Vertical axis wind turbine airfoil

    Krivcov, Vladimir; Krivospitski, Vladimir; Maksimov, Vasili; Halstead, Richard; Grahov, Jurij Vasiljevich


    A vertical axis wind turbine airfoil is described. The wind turbine airfoil can include a leading edge, a trailing edge, an upper curved surface, a lower curved surface, and a centerline running between the upper surface and the lower surface and from the leading edge to the trailing edge. The airfoil can be configured so that the distance between the centerline and the upper surface is the same as the distance between the centerline and the lower surface at all points along the length of the airfoil. A plurality of such airfoils can be included in a vertical axis wind turbine. These airfoils can be vertically disposed and can rotate about a vertical axis.

  2. Two-axis angular effector

    A new class of coplanar two-axis angular effectors is described. These effectors combine a two-axis rotational joint analogous to a Cardan joint with linear actuators in a manner to produce a wider range of rotational motion about both axes defined by the joint. This new class of effectors also allows design of robotic manipulators having very high strength and efficiency. These effectors are particularly suited for remote operation in unknown surroundings, because of their extraordinary versatility. An immediate application is to the problems which arise in nuclear waste remediation. 11 figs

  3. Helical axis stellarator equilibrium model

    An asymptotic model is developed to study MHD equilibria in toroidal systems with a helical magnetic axis. Using a characteristic coordinate system based on the vacuum field lines, the equilibrium problem is reduced to a two-dimensional generalized partial differential equation of the Grad-Shafranov type. A stellarator-expansion free-boundary equilibrium code is modified to solve the helical-axis equations. The expansion model is used to predict the equilibrium properties of Asperators NP-3 and NP-4. Numerically determined flux surfaces, magnetic well, transform, and shear are presented. The equilibria show a toroidal Shafranov shift

  4. Vertical axis wind turbine acoustics

    Pearson, Charlie


    Increasing awareness of the issues of climate change and sustainable energy use has led to growing levels of interest in small-scale, decentralised power generation. Small-scale wind power has seen significant growth in the last ten years, partly due to the political support for renewable energy and the introduction of Feed In Tariffs, which pay home owners for generating their own electricity. Due to their ability to respond quickly to changing wind conditions, small-scale vertical axis...

  5. Hypothalamus-Pituitary-Thyroid Axis.

    Ortiga-Carvalho, Tania M; Chiamolera, Maria I; Pazos-Moura, Carmen C; Wondisford, Fredic E


    The hypothalamus-pituitary-thyroid (HPT) axis determines the set point of thyroid hormone (TH) production. Hypothalamic thyrotropin-releasing hormone (TRH) stimulates the synthesis and secretion of pituitary thyrotropin (thyroid-stimulating hormone, TSH), which acts at the thyroid to stimulate all steps of TH biosynthesis and secretion. The THs thyroxine (T4) and triiodothyronine (T3) control the secretion of TRH and TSH by negative feedback to maintain physiological levels of the main hormones of the HPT axis. Reduction of circulating TH levels due to primary thyroid failure results in increased TRH and TSH production, whereas the opposite occurs when circulating THs are in excess. Other neural, humoral, and local factors modulate the HPT axis and, in specific situations, determine alterations in the physiological function of the axis. The roles of THs are vital to nervous system development, linear growth, energetic metabolism, and thermogenesis. THs also regulate the hepatic metabolism of nutrients, fluid balance and the cardiovascular system. In cells, TH actions are mediated mainly by nuclear TH receptors (210), which modify gene expression. T3 is the preferred ligand of THR, whereas T4, the serum concentration of which is 100-fold higher than that of T3, undergoes extra-thyroidal conversion to T3. This conversion is catalyzed by 5'-deiodinases (D1 and D2), which are TH-activating enzymes. T4 can also be inactivated by conversion to reverse T3, which has very low affinity for THR, by 5-deiodinase (D3). The regulation of deiodinases, particularly D2, and TH transporters at the cell membrane control T3 availability, which is fundamental for TH action. © 2016 American Physiological Society. Compr Physiol 6:1387-1428, 2016. PMID:27347897

  6. Introductory lecture on triple-axis spectrometer

    Triple-axis spectrometer is a multi-purpose instrument for powder neutron diffraction, single crystal neutron diffraction, powder inelastic neutron scattering, single crystal inelastic neutron scattering, and neutron polarization analysis. In this lecture how to use the triple-axis spectrometer is explained for the beginners. (author)

  7. Identification of kinematic errors of five-axis machine tool trunnion axis from finished test piece

    Zhang, Ya; Fu, Jianzhong; Chen, Zichen


    Compared with the traditional non-cutting measurement, machining tests can more accurately reflect the kinematic errors of five-axis machine tools in the actual machining process for the users. However, measurement and calculation of the machining tests in the literature are quite difficult and time-consuming. A new method of the machining tests for the trunnion axis of five-axis machine tool is proposed. Firstly, a simple mathematical model of the cradle-type five-axis machine tool was established by optimizing the coordinate system settings based on robot kinematics. Then, the machining tests based on error-sensitive directions were proposed to identify the kinematic errors of the trunnion axis of cradle-type five-axis machine tool. By adopting the error-sensitive vectors in the matrix calculation, the functional relationship equations between the machining errors of the test piece in the error-sensitive directions and the kinematic errors of C-axis and A-axis of five-axis machine tool rotary table was established based on the model of the kinematic errors. According to our previous work, the kinematic errors of C-axis can be treated as the known quantities, and the kinematic errors of A-axis can be obtained from the equations. This method was tested in Mikron UCP600 vertical machining center. The machining errors in the error-sensitive directions can be obtained by CMM inspection from the finished test piece to identify the kinematic errors of five-axis machine tool trunnion axis. Experimental results demonstrated that the proposed method can reduce the complexity, cost, and the time consumed substantially, and has a wider applicability. This paper proposes a new method of the machining tests for the trunnion axis of five-axis machine tool.

  8. Axis intersection measurement of three-axis turntable with two crosshair targets

    REN Shun-qing; MA Guang-cheng; WANG Chang-hong


    In order to measure three-axis intersection error, two crosshair targets were fixed in the inner axis frame of a three-axis turntable. Also a theodolite was used to point its telescope to the targets and to measure the horizontal angles when three axes were on equi-spaced angle positions. The calculation equations of the axis intersection were deduced from the mounting position of the theodolite, positions of two targets, angular positions of three axes, and the measured horizontal angles with the theodolite. Finally, a practical measurement is carried out on a horizontal three-axis turntable and error analysis is conducted.

  9. An Elevated Maternal Plasma Soluble fms-Like Tyrosine Kinase-1 to Placental Growth Factor Ratio at Midtrimester Is a Useful Predictor for Preeclampsia

    Mahmoud Fathy Hassan


    Full Text Available Background. To assess the ability of mid-trimester sFlt-1/PlGF ratio for prediction of preeclampsia in two different Arabic populations. Methods. This study measured levels of sFlt-1, PlGF, and sFlt-1/PlGF ratio at midtrimester in 83 patients who developed preeclampsia with contemporary 250 matched controls. Results. Women subsequently developed preeclampsia had significantly lower PlGF levels and higher sFlt-1 and sFlt-1/PlGF ratio levels than women with normal pregnancies (P<0.0001 for all. Women who with preterm preeclampsia had significantly higher sFlt-1 and sFlt-1/PlGF ratio than term preeclamptic women (P=0.01, 0.003, resp.. A cutoff value of 3198 pg/mL for sFlt-1 was able to predict preeclampsia with sensitivity, specificity, and accuracy of 88%, 83.6%, and 84.7%, respectively, with odds ratio (OR 37.2 [95% confidence interval (CI 17.7–78.1]. PIGF at cutoff value of 138 pg/mL was able to predict preeclampsia with sensitivity, specificity, and accuracy of 85.5%, 77.2%, and 79.3%, respectively, with OR 20 [95% CI, 10.2–39.5]. The sFlt-1/PIGF ratio at cutoff value of 24.5 was able to predict preeclampsia with sensitivity, specificity, and accuracy of 91.6%, 86.4%, and 87.7%, respectively with OR 67 [95% CI, 29.3–162.1]. Conclusion. Midtrimester sFlt-1/PlGF ratio displayed the highest sensitivity, specificity, accuracy, and OR for prediction of preeclampsia, demonstrating that it may stipulate more effective prediction of preeclampsia development than individual factor assay.

  10. Fms like tyrosine kinase (FLT3) and nucleophosmin 1 (NPM1) mutations in de novo normal karyotype acute myeloid leukemia (AML).

    Dunna, Nageswara Rao; Rajappa, Senthil; Digumarti, Raghunadharao; Vure, Sugunakar; Kagita, Sailaja; Damineni, Surekha; Rao, V R; Yadav, Satish Kumar; Ravuri, Rajasekhara Reddy; Satti, Vishnupriya


    Mutations in FLT3 and NPM1 are important prognostic factors in AML, influencing outcome in normal karyotype cases. We here analysed incidences of FLT3/ITD, D 835 and NPM1 mutations in patients with de novo normal karyotype AML using PCR and gene sequencing, along with laboratory parameters and treatment outcomes. There were 128 patients with a median age of 45 years (range, 19-65). FLT3/ITD mutations were detected in 26 (20.3%), FLT3/D835 in 8 (6.2%) and NPM1 in 22 (17.1%). The incidence of FLT3/ITD was higher in those with elevated lactate dehydrogenase (LDH) and peripheral blasts (p=< 0.002, < 0.001) while NPM1 mutations or both NPM1 and FLT3/ITD was more common in elevated total leukocyte counts (TLC), LDH and peripheral blasts (p=<0.0001). Complete response and disease free survival were lower in those with FLT3/ITD mutations (p=0.04, 0.03). The incidence of FLT3 and NPM1 mutations was found to be low in Indian patients with normal karyotype AML. PMID:21338238

  11. Design of off-axis PIAACMC mirrors

    Pluzhnik, Eugene; Guyon, Olivier; Belikov, Ruslan; Bendek, Eduardo


    The Phase-Induced Amplitude Apodization Complex Mask Coronagraph (PIAACMC) provides an efficient way to control diffraction propagation effects caused by the central obstruction/segmented mirrors of the telescope. PIAACMC can be optimized in a way that takes into account both chromatic diffraction effects caused by the telescope obstructed aperture and tip/tilt sensitivity of the coronagraph. As a result, unlike classic PIAA, the PIAACMC mirror shapes are often slightly asymmetric even for an on-axis configuration and require more care in calculating off-axis shapes when an off-axis configuration is preferred. A method to design off-axis PIAA mirror shapes given an on-axis mirror design is presented. The algorithm is based on geometrical ray tracing and is able to calculate off-axis PIAA mirror shapes for an arbitrary geometry of the input and output beams. The method is demonstrated using the third generation PIAACMC design for WFIRST-AFTA telescope. Geometrical optics design issues related to the off-axis diffraction propagation effects are also discussed.

  12. New Urban Vertical Axis Wind Turbine Design

    Alexandru-Mihai CISMILIANU; Alexandru BOROS; Ionut-Cosmin ONCESCU; Florin FRUNZULICA


    This paper develops a different approach for enhancing the performance of Vertical Axis Wind Turbines for the use in the urban or rural environment and remote isolated residential areas. Recently the vertical axis wind turbines (VAWT) have become more attractive due to the major advantages of this type of turbines in comparison to the horizontal axis wind turbines. We aim to enhance the overall performance of the VAWT by adding a second set of blades (3 x 2=6 blades) following the rules of bi...

  13. Plasma stabilization in traps with spatial axis

    Possible methods of plasma stabilization within traps with spatial axis for both circular and triangular-elliptic magnetic surfaces, applicable to Dracon, Spitzer's Eight and Heliac, are studied theoretically. (author). 18 refs, 5 figs

  14. Axis of Zodiacal light Near Tropic Cancer

    Nawar, S; Mikhail, J S; Morcos, A B; Ibrahim, Alhassan I


    The axis of zodiacal lights have been obtained in blue and yellow colors using photoelectric observations of zodiacal light. These observations have been carried out at Abu Simbel Site in Egypt, in October 1975. This site lies too near to the tropic of Cancer, at which the axis of the zodiacal light cone perpendiculars to the horizon. The results show that the plane of the zodiacal light is inclined to the normal by 1.59 degrees in blue color and 1.18 degrees in yellow color. This means that there is a slight variation in zodiacal light axis with wavelength, and the axis almost coincide with the ecliptic. The present results for blue color can be considered as the first one in the world near the tropic of Cancer.

  15. UMAPRM: Uniformly sampling the medial axis

    Yeh, Hsin-Yi Cindy


    © 2014 IEEE. Maintaining clearance, or distance from obstacles, is a vital component of successful motion planning algorithms. Maintaining high clearance often creates safer paths for robots. Contemporary sampling-based planning algorithms That utilize The medial axis, or The set of all points equidistant To Two or more obstacles, produce higher clearance paths. However, They are biased heavily Toward certain portions of The medial axis, sometimes ignoring parts critical To planning, e.g., specific Types of narrow passages. We introduce Uniform Medial Axis Probabilistic RoadMap (UMAPRM), a novel planning variant That generates samples uniformly on The medial axis of The free portion of Cspace. We Theoretically analyze The distribution generated by UMAPRM and show its uniformity. Our results show That UMAPRM\\'s distribution of samples along The medial axis is not only uniform but also preferable To other medial axis samplers in certain planning problems. We demonstrate That UMAPRM has negligible computational overhead over other sampling Techniques and can solve problems The others could not, e.g., a bug Trap. Finally, we demonstrate UMAPRM successfully generates higher clearance paths in The examples.

  16. Actuator assembly including a single axis of rotation locking member

    Quitmeyer, James N.; Benson, Dwayne M.; Geck, Kellan P.


    An actuator assembly including an actuator housing assembly and a single axis of rotation locking member fixedly attached to a portion of the actuator housing assembly and an external mounting structure. The single axis of rotation locking member restricting rotational movement of the actuator housing assembly about at least one axis. The single axis of rotation locking member is coupled at a first end to the actuator housing assembly about a Y axis and at a angle to an X and Z axis providing rotation of the actuator housing assembly about the Y axis. The single axis of rotation locking member is coupled at a second end to a mounting structure, and more particularly a mounting pin, about an X axis and at a angle to a Y and Z axis providing rotation of the actuator housing assembly about the X axis. The actuator assembly is thereby restricted from rotation about the Z axis.

  17. [Leptin and hypothalamus-hypophysis-thyroid axis].

    Riccioni, G; Menna, V; Lambo, M S; Della Vecchia, R; Di Ilio, C; De Lorenzo, A; D'Orazio, N


    The leptin system is a major regulator of food intake and metabolic rate. The leptin, an adipose tissue hormone whose plasma levels reflect energy stores, plays an important rule in the pathogenesis of such eating disorders like bulimia and anorexia. Thyroid hormones are major regulators of energy homeostasis. It is possible that leptin and thyroid hormone exert their actions on thermogenesis and energy metabolism via the same common effector patways. Leptin influences feedback regulation of the hypotalamic TRH-secreting neurons by thyroid hormone. Low serum levels of thyroid hormones reflect a dysfunction of the hypotalamic-pituitary-thyroid (HPT) and hypotalamic-pituitary-adrenal (HPA) axis in patients with nervosa anorexia. Neuroendocrine effects of leptin include effects on the HPT and HPA axis. The aim of this work is to evaluated the interactions between leptina and HPT axis on the basis of recent published works and reviews in literature. PMID:15147079

  18. New Urban Vertical Axis Wind Turbine Design

    Alexandru-Mihai CISMILIANU


    Full Text Available This paper develops a different approach for enhancing the performance of Vertical Axis Wind Turbines for the use in the urban or rural environment and remote isolated residential areas. Recently the vertical axis wind turbines (VAWT have become more attractive due to the major advantages of this type of turbines in comparison to the horizontal axis wind turbines. We aim to enhance the overall performance of the VAWT by adding a second set of blades (3 x 2=6 blades following the rules of biplane airplanes. The model has been made to operate at a maximum power in the range of the TSR between 2 to 2.5. The performances of the VAWT were investigated numerically and experimentally and justify the new proposed design.

  19. Diffuser Augmented Horizontal Axis Tidal Current Turbines

    Nasir Mehmood


    Full Text Available The renewal energy technologies are increasingly popular to ensure future energy sustenance and address environmental issues. The tides are enormous and consistent untapped resource of renewable energy. The growing interest in exploring tidal energy has compelling reasons such as security and diversity of supply, intermittent but predictable and limited social and environmental impacts. The tidal energy industry is undergoing an increasing shift towards diffuser augmented turbines. The reason is the higher power output of diffuser augmented turbines compared to conventional open turbines. The purpose of this study is to present a comprehensive review of diffuser augmented horizontal axis tidal current turbines. The components, relative advantages, limitations and design parameters of diffuser augmented horizontal axis tidal current turbines are presented in detail. CFD simulation of NACA 0016 airfoil is carried out to explore its potential for designing a diffuser. The core issues associated with diffuser augmented horizontal axis tidal current turbines are also discussed.

  20. Modular off-axis solar concentrator

    Plesniak, Adam P; Hall, John C


    A solar concentrator including a housing defining a vertical axis and including a receiving wall connected to a reflecting wall to define an internal volume and an opening into the internal volume, wherein the reflecting wall defines at least one primary optical element, and wherein at least a portion of the reflecting wall includes a layer of reflective material, the housing further including a cover connected to the receiving wall and the reflecting wall to seal the opening, and at least one receiver mounted on the receiving wall such that a vertical axis of the receiver is disposed at a non-zero angle relative to the vertical axis of the housing, the receiver including at least one photovoltaic cell.

  1. Aeroelastically coupled blades for vertical axis wind turbines

    Paquette, Joshua; Barone, Matthew F.


    Various technologies described herein pertain to a vertical axis wind turbine blade configured to rotate about a rotation axis. The vertical axis wind turbine blade includes at least an attachment segment, a rear swept segment, and optionally, a forward swept segment. The attachment segment is contiguous with the forward swept segment, and the forward swept segment is contiguous with the rear swept segment. The attachment segment includes a first portion of a centroid axis, the forward swept segment includes a second portion of the centroid axis, and the rear swept segment includes a third portion of the centroid axis. The second portion of the centroid axis is angularly displaced ahead of the first portion of the centroid axis and the third portion of the centroid axis is angularly displaced behind the first portion of the centroid axis in the direction of rotation about the rotation axis.

  2. Solar rotating magnetic dipole?. [around axis perpendicular to rotation axis of the sun

    Antonucci, E.


    A magnetic dipole rotating around an axis perpendicular to the rotation axis of the sun can account for the characteristics of the surface large-scale solar magnetic fields through the solar cycle. The polarity patterns of the interplanetary magnetic field, predictable from this model, agree with the observed interplanetary magnetic sector structure.

  3. Generator design for vertical axis wind turbine

    Schüller, Espen Samuelsen


    The optimization process for generators are often done for rated speeds and torques. This thesis will discuss and show optimization of a vertical axis wind turbine generator that has a given wind profile. Although the rated power of the turbine is at winds of about 10 m/s, the wind is mostly at 4-6 m/s, thus needing a generator that has high efficiencies also at lower speeds and torques.Vertical axis wind turbine does not use blade pitching as the horizontal ones do and the torque and speed c...

  4. Lift Augmentation for Vertical Axis Wind Turbines

    Gerald M Angle II; Mary Ann Clarke


    The concept of harnessing wind power has been around for centuries, and is first recorded by the Persians in 900 AD. These early uses of wind power were for the processing of food, particularly grinding grains, and consisted of stationary blades around a horizontal axis, the precursor to today’s horizontal axis wind turbines (HAWT). Technology for these wind mills was essentially the same until the 1930’s when advances in aircraft propeller theories were applied to the blades of the turbine. ...

  5. Research of misalignment between dithered ring laser gyro angle rate input axis and dither axis

    Li, Geng; Wu, Wenqi; FAN, Zhenfang; LU, Guangfeng; Hu, Shaomin; Luo, Hui; Long, Xingwu


    The strap-down inertial navigation system (SINS), especially the SINS composed by dithered ring laser gyroscope (DRLG) is a kind of equipment, which providing high reliability and performance for moving vehicles. However, the mechanical dither which is used to eliminate the "Lock-In" effect can cause vibration disturbance to the INS and lead to dithering coupling problem in the inertial measurement unit (IMU) gyroscope triad, so its further application is limited. Among DRLG errors between the true gyro rotation rate and the measured rotation rate, the frequently considered one is the input axis misalignment between input reference axis which is perpendicular to the mounting surface and gyro angular rate input axis. But the misalignment angle between DRLG dither axis and gyro angular rate input axis is often ignored by researchers, which is amplified by dither coupling problem and that would lead to negative effects especially in high accuracy SINS. In order to study the problem more clearly, the concept of misalignment between DRLG dither axis and gyro angle rate input axis is researched. Considering the error of misalignment is of the order of 10-3 rad. or even smaller, the best way to measure it is using DRLG itself by means of an angle exciter as an auxiliary. In this paper, the concept of dither axis misalignment is explained explicitly firstly, based on this, the frequency of angle exciter is induced as reference parameter, when DRLG is mounted on the angle exciter in a certain angle, the projections of angle exciter rotation rate and mechanical oscillation rate on the gyro input axis are both sensed by DRLG. If the dither axis has misalignment error with the gyro input axis, there will be four major frequencies detected: the frequency of angle exciter, the dither mechanical frequency, sum and difference frequencies of the former two frequencies. Then the amplitude spectrum of DRLG output signal obtained by the using LabVIEW program. if there are only angle

  6. The Trading Axis in Irkutsk Downtown

    Elena Grigoryeva


    Full Text Available The article reveals a linear concentration of the trading function in the historical center of Irkutsk. It features historical prerequisites and continuation of the tradition in the post-Soviet period, given the conversion of plants and factories. The article analyses the current state and prospects of modernization of the trading axis with its transformation into a modern public space.

  7. Resolution of a triple axis spectrometer

    Nielsen, Mourits; Bjerrum Møller, Hans

    A new method for obtaining the resolution function for a triple-axis neutron spectrometer is described, involving a combination of direct measurement and analytical calculation. All factors which contribute to the finite resolution of the instrument may be taken into account, and Gaussian or...

  8. Triple-axis spectrometer DruechaL

    DruechaL is a triple-axis spectrometer located at a cold guide. The characteristics of guide and instrument allow the use of a broad spectral range of neutrons. The resolution in momentum and energy transfer can be tuned to match the experimental requirements by using either collimators or focusing systems (monochromator, antitrumpet, analyser). (author) figs., tabs., refs

  9. Fibrous dysplasia in axis treated with vertebroplasty

    Kadir Kotil


    Full Text Available Vertebroplasty of the axis is a challenging procedure, and little is known about its therapeutic outcome. Cervical fibrous dysplasia with a distinct cyst is a rare entity and few cases have been reported in the literature. A 55-year-old man with fibrous dysplasia of axis presented with severe neck pain and left arm since six months. Computed tomography and magnetic resonance imaging revealed an expansile, destructive lesion involving the axis, and no spinal cord. He was submitted to retropharyngeal surgery and the lesion was fulled by vertebroplasty. Microscopic examination was consistent with the diagnosis of monostotic fibrous dysplasia. After the surgery no recurrence was observed. The patient had remarkable improvement in clinical relief of neck pain at 1-year follow-up. Although there are descriptions of vertebral fibrous dysplasia, this is the 13th case of monostotic fibrous dysplasia of the cervical spine, and the 3rd case of the axis described in the literature. The unique case who had treated with ope vertebroplasty.

  10. Horizontal Axis Levitron--A Physics Demonstration

    Michaelis, Max M.


    After a brief history of the Levitron, the first horizontal axis Levitron is reported. Because it is easy to operate, it lends itself to educational physics experiments and analogies. Precession and nutation are visualized by reflecting the beam from a laser pointer off the "spignet". Precession is fundamental to nuclear magnetic…

  11. Thyroid axis alterations in childhood obesity.

    Gertig, Anna M; Niechciał, Elżbieta; Skowrońska, Bogda


    In recent years researchers have become increasingly interested in the particular relation between the function of the thyroid gland and the body mass in the population of obese children. Numerous studies have been conducted and the literature on the related issues has been abounding. Several thereof have strived at pinpointing a significant link between the function of the thyroid axis and the body mass. Yet, it still remains to be clarified whether these subtle changes in the level of thyroid hormones and TSH observed in childhood obesity are responsible for the increased body mass or rather they represent a secondary phenomenon. The mechanism most often put forward by the researchers that links obesity to thyroid function is the increased level of leptin, which affects neurones in the hypothalamus and the thyroid axis causing TRH and TSH secretion. The body mass is positively correlated with serum leptin and elevated level of leptin is connected with an increase in TSH level. However, there is still controversy whether these inconspicuous differences observed in thyroid axis merit the treatment with thyroxine since these changes seem to constitute a consequence rather than a cause of obesity. Therefore, as most authors postulate, primary importance should be placed on lifestyle changes and body weight reduction leaving substitutive treatment as a supplementary option. The purpose of this review is to present the most current issues on child obesity and the related malfunction of the thyroid axis through an overview of international publications from the years 1996-2011. PMID:23146791

  12. Tennis Rackets and the Parallel Axis Theorem

    Christie, Derek


    This simple experiment uses an unusual graph straightening exercise to confirm the parallel axis theorem for an irregular object. Along the way, it estimates experimental values for g and the moment of inertia of a tennis racket. We use Excel to find a 95% confidence interval for the true values.

  13. Triple-axis spectrometer DruechaL

    Buehrer, W.; Keller, P. [Lab. for Neutron Scattering ETH Zurich, Zurich (Switzerland) and Paul Scherrer Institute, Villigen (Switzerland)


    DruechaL is a triple-axis spectrometer located at a cold guide. The characteristics of guide and instrument allow the use of a broad spectral range of neutrons. The resolution in momentum and energy transfer can be tuned to match the experimental requirements by using either collimators or focusing systems (monochromator, antitrumpet, analyser). (author) figs., tabs., refs.

  14. Vortex capturing vertical axis wind turbine

    An analytical-numerical study is presented for an innovative lift vertical axis turbine whose blades are designed with vortex trapping cavities that act as passive flow control devices. The unsteady flow field past one-bladed and two-bladed turbines is described by a combined analytical and numerical method based on conformal mapping and on a blob vortex method

  15. Multi-Axis Accelerometer Calibration System

    Finley, Tom; Parker, Peter


    A low-cost, portable, and simplified system has been developed that is suitable for in-situ calibration and/or evaluation of multi-axis inertial measurement instruments. This system overcomes facility restrictions and maintains or improves the calibration quality for users of accelerometer-based instruments with applications in avionics, experimental wind tunnel research, and force balance calibration applications. The apparatus quickly and easily positions a multi-axis accelerometer system into a precisely known orientation suitable for in-situ quality checks and calibration. In addition, the system incorporates powerful and sophisticated statistical methods, known as response surface methodology and statistical quality control. These methods improve calibration quality, reduce calibration time, and allow for increased calibration frequency, which enables the monitoring of instrument stability over time.

  16. Local Pancake Defeats Axis of Evil

    Vale, Chris


    Among the biggest surprises revealed by COBE and confirmed by WMAP measurements of the temperature anisotropy of the CMB are the anomalous features in the 2-point angular correlation function on very large angular scales. In particular, the $\\ell = 2$ quadrupole and $\\ell = 3$ octopole terms are surprisingly planar and aligned with one another, which is highly unlikely for a statistically isotropic Gaussian random field, and the axis of the combined low-$\\ell$ signal is perpendicular to eclip...

  17. Parking Strategies for Vertical Axis Wind Turbines


    Strategies for parking a vertical axis wind turbine at storm load are considered. It is proposed that if a directly driven permanent magnet synchronous generator is used, an elegant choice is to short-circuit the generator at storm, since this makes the turbine efficiently damped. Nondamped braking is found to be especially problematic for the case of two blades where torsional oscillations may imply thrust force oscillations within a range of frequencies.

  18. Turbulence in vertical axis wind turbine canopies

    Kinzel, Matthias; Araya, Daniel B.; Dabiri, John O.


    Experimental results from three different full scale arrays of vertical-axis wind turbines (VAWTs) under natural wind conditions are presented. The wind velocities throughout the turbine arrays are measured using a portable meteorological tower with seven, vertically staggered, three-component ultrasonic anemometers. The power output of each turbine is recorded simultaneously. The comparison between the horizontal and vertical energy transport for the different turbine array sizes shows the i...

  19. Methamphetamine and the hypothalamic-pituitary-adrenal axis

    Zuloaga, Damian G.; Jacosbskind, Jason S.; Raber, Jacob


    Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute to addictive processes such as relapse. In this mini-review we discuss acute and chronic effects of MA (adult and developmental exposure) on the HPA axis, including effects on HPA axis associated genes/proteins, brain regions, and behaviors such...

  20. Horizontal axis Levitron—a physics demonstration

    Michaelis, Max M.


    After a brief history of the Levitron, the first horizontal axis Levitron is reported. Because it is easy to operate, it lends itself to educational physics experiments and analogies. Precession and nutation are visualized by reflecting the beam from a laser pointer off the ‘spignet’. Precession is fundamental to nuclear magnetic resonance, magnetic resonance imaging, particle traps and the movement of bodies in space. Longitudinal and lateral bounce behaviour is explained via ‘the principle of gentle superposition’ of two traps: the micro-precessional and the macro-trap. Theory is initiated. Scaling experiments are mentioned. Industrial applications might follow. Patent pending.

  1. A Portable Single Axis Magnetic Gradiometer

    Merayo, José M.G.; Petersen, Jan Raagaard; Nielsen, Otto V;


    The single axis magnetic gradiometer based on two compact detector compensation (CDC) fluxgate ringcore sensors separated 20 cm is described. Despite its high stability and precision better than 1 nT, the calibration procedures are not straightforward. Firstly, the mono-axial measurement does...... not provide vector information about the magnetic field. Secondly, one of the sensors measures the ambient magnetic field and is used to compensate for the main field at both sensors. Several methods have been developed for characterization of the 2 gradiometer, and the calibration of the gradient...

  2. Pulsed 3-Axis Vector SERF Magnetometer

    Hedges, Morgan; Romalis, Michael


    We demonstrate a 3-axis atomic vector magnetometer operating in the SERF regime, using a single beam path, and capable of operating in Earth's field using field feedback. It has similar sensitivity along all 3 axes that is fundamentally limited by photon and atom shot noise. The scheme uses a high intensity pump pulse to polarize Rb atoms in ~ 1 μs and a sequence of magnetic field pulses applied while the atoms are monitored during free precession. The sequence used provides minimal sensitivity to pulse errors, while also allowing unambiguous discrimination between external magnetic fields and misalignment between laser and magnetic coil axes.

  3. Optimisation of vertical axis wind turbines

    Roynarin, Wirachai


    A practical Vertical Axis Wind Turbine (VAWTs) based on a Darrieus rotor has been designed and tested and found to be capable of self-starting at wind speeds above 4m/s. The self-start feature has been achieved by replacing the usual symmetrical aerofoil blade in the VAWT rotor and by using a concentric Savonius rotor or semi-cylinder turbine. A computer program was produced to compute the power coefficient versus tip speed ratio characteristics of a selected aerofoil profile employed in a VA...

  4. Equilibrium calculations for helical axis stellarators

    An average method based on a vacuum flux coordinate system is presented. This average method permits the study of helical axis stellarators with toroidally dominated shifts. An ordering is introduced, and to lowest order the toroidally averaged equilibrium equations are reduced to a Grad-Shafranov equation. Also, to lowest order, a Poisson-type equation is obtained for the toroidally varying corrections to the equilibium. By including these corrections, systems that are toroidally dominated, but with significant helical distortion to the equilibrium, may be studied. Numerical solutions of the average method equations are shown to agree well with three-dimensional calculations

  5. Single-axis gyroscopic motion with uncertain angular velocity about spin axis

    Singh, S. N.


    A differential game approach is presented for studying the response of a gyro by treating the controlled angular velocity about the input axis as the evader, and the bounded but uncertain angular velocity about the spin axis as the pursuer. When the uncertain angular velocity about the spin axis desires to force the gyro to saturation a differential game problem with two terminal surfaces results, whereas when the evader desires to attain the equilibrium state the usual game with single terminal manifold arises. A barrier, delineating the capture zone (CZ) in which the gyro can attain saturation and the escape zone (EZ) in which the evader avoids saturation is obtained. The CZ is further delineated into two subregions such that the states in each subregion can be forced on a definite target manifold. The application of the game theoretic approach to Control Moment Gyro is briefly discussed.

  6. VERITAS: Versatile Triple-Axis Spectrometer

    Park, Sung Il


    Korea Atomic Energy Research Institute is planning to build a cold neutron triple-axis spectrometer at HANARO, the 30 MW research reactor. The spectrometer is expected to be completed in 2008 with the following configuration from the upstream to the downstream. Guide Supermirror m = 2, In-pile Straight Section, {approx} 5 m Curved Guide, {approx} 26 m w/ R 1500 m Straight Guide before the Instrument, {approx} 40 m Filters PG and Be Neutron Velocity Selector (Future) Monochromators Vertically Focusing Monochromators PG(002) and Heusler(111) Doubly Focusing Monochromators (Future) Monochromator-Sample Distance 2 m Collimation C1 Soller Collimators, 20', 40' 80'Beam Height at the Sample Table 1.5 m Sample-Analyzer Distance 1.0 m Collimation C2 Soller Collimators, 20', 40', 80' Radial Collimator Analyzers Horizontally Focusing Analyzers w/ Fixed Vertical Focusing PG(002) and Heusler(111) Analyzer-Detector Distance 0.5 m Detectors 5 cm Tube Detector 25 cm wide Position Sensitive Detector Once completed, the neutron flux at sample is expected to surpass that of SPINS at NCNR, making this instrument one of the most powerful 2nd generation cold neutron triple-axis spectrometers in the world.

  7. VERITAS: Versatile Triple-Axis Spectrometer

    Korea Atomic Energy Research Institute is planning to build a cold neutron triple-axis spectrometer at HANARO, the 30 MW research reactor. The spectrometer is expected to be completed in 2008 with the following configuration from the upstream to the downstream. Guide Supermirror m = 2, In-pile Straight Section, ∼ 5 m Curved Guide, ∼ 26 m w/ R 1500 m Straight Guide before the Instrument, ∼ 40 m Filters PG and Be Neutron Velocity Selector (Future) Monochromators Vertically Focusing Monochromators PG(002) and Heusler(111) Doubly Focusing Monochromators (Future) Monochromator-Sample Distance 2 m Collimation C1 Soller Collimators, 20', 40' 80'Beam Height at the Sample Table 1.5 m Sample-Analyzer Distance 1.0 m Collimation C2 Soller Collimators, 20', 40', 80' Radial Collimator Analyzers Horizontally Focusing Analyzers w/ Fixed Vertical Focusing PG(002) and Heusler(111) Analyzer-Detector Distance 0.5 m Detectors 5 cm Tube Detector 25 cm wide Position Sensitive Detector Once completed, the neutron flux at sample is expected to surpass that of SPINS at NCNR, making this instrument one of the most powerful 2nd generation cold neutron triple-axis spectrometers in the world

  8. Computer Assisted Mechanical Axis and Kinematic TKA

    McEwen, Peter; Mahoharan, Varaguna


    Introduction: Total knee arthroplasty (TKA) has traditionally been and largely continues to be aligned mechanically, that being with a neutral coronal plane mechanical tibiofemoral axis and a joint line orientated at 900 to this axis. Femoral component rotation is set by gap balancing or by externally rotating 30 from any of a number femoral reference lines. This produces a rectangular flexion gap and relaxes patellar tracking. Kinematic alignment (KA) is an alternative technique that aims to restore premorbid alignment, joint orientation and ligament tension. The basic premise for this technique is based on evidence that the medial and lateral femoral condyles consistently equate to cylinders of equal or near equal size and that therefore with a fixed radius, cruciate retaining implant, matched distal femoral, posterior femoral and proximal tibial resections, accounting for bone and cartilage already lost will reproduce the premorbid joint line and restore native premorbid kinematics. Femoral rotation is therefore referenced off the prearthritic posterior condylar axis (PCA) that is on average internally rotated to the AP axis. Kinematic alignment therefore has the potential to challenge patellar tracking, increase patellar load and potentially increase patellar complications. Method: Case control study – level of evidence III-2. Between November 2012 and June 2013 the senior author completed 104 consecutive computer assisted (CAS) kinematically aligned total knee arthroplasties (TKA) with a cruciate retaining, fixed bearing, single radius implant. The results of these surgeries were compared with the results of 91 consecutive CAS mechanically aligned TKA done between November 2011 and October 2012 using the same navigation system and implant Implant sizing and positioning as well as gap measurement and ligament balance was done with computer assistance in all cases. Data was collected prospectively and analysed retrospectively. Results: The Oxford Knee Score

  9. Lift Augmentation for Vertical Axis Wind Turbines

    Gerald M Angle II


    Full Text Available The concept of harnessing wind power has been around for centuries, and is first recorded by the Persians in 900 AD. These early uses of wind power were for the processing of food, particularly grinding grains, and consisted of stationary blades around a horizontal axis, the precursor to today’s horizontal axis wind turbines (HAWT. Technology for these wind mills was essentially the same until the 1930’s when advances in aircraft propeller theories were applied to the blades of the turbine. During this development period, which has since remained basically unchanged, the design push was for increasingly larger propellers requiring heavy and costly transmissions, generators, and support towers to be installed. An alternative concept to the HAWT was developed by Georges Darrieus [5], which utilized a vertical shaft and is known as a vertical axis wind turbine (VAWT. The scientific development of the concept did not gain strong attention until the 1970’s due to the perceived low efficiency of this style. This perception was due in part to the portion of the blade’s rotary path that is adverse to the generation of power. This efficiency loss can be minimized by the mechanical movement of the blade, relative to the airflow during the upwind portion of the blades’ rotational path. Since, circulation control can alter the forces generated by an airfoil, it could be used to increase the efficiency of a VAWT by increasing the torque produced on the downwind portion of the path, while removing the need for a physical change in angle of attack. With the recent upturn in petroleum costs and global warming concerns, interest in renewable energy technologies have been reinvigorated, in particular the desire for advanced wind energy technologies, including the application of lift augmentation techniques. One of these techniques is to utilize circulation control to enhance the lifting capacity of the blades based on the location of the blade in the

  10. Model for performance prediction in multi-axis machining

    Lavernhe, Sylvain; Lartigue, Claire; 10.1007/s00170-007-1001-4


    This paper deals with a predictive model of kinematical performance in 5-axis milling within the context of High Speed Machining. Indeed, 5-axis high speed milling makes it possible to improve quality and productivity thanks to the degrees of freedom brought by the tool axis orientation. The tool axis orientation can be set efficiently in terms of productivity by considering kinematical constraints resulting from the set machine-tool/NC unit. Capacities of each axis as well as some NC unit functions can be expressed as limiting constraints. The proposed model relies on each axis displacement in the joint space of the machine-tool and predicts the most limiting axis for each trajectory segment. Thus, the calculation of the tool feedrate can be performed highlighting zones for which the programmed feedrate is not reached. This constitutes an indicator for trajectory optimization. The efficiency of the model is illustrated through examples. Finally, the model could be used for optimizing process planning.

  11. Five-axis rough machining for impellers

    Ruolong QI; Weijun LIU; Hongyou BIAN; Lun LI


    The most important components used in aero-space, ships, and automobiles are designed with free form surfaces. An impeller is one of the most important components that is difficult to machine because of its twisted blades. Rough machining is recognized as the most crucial procedure influencing machining efficiency and is critical for the finishing process. An integrated rough machining course with detailed algorithms is presented in this paper. An algorithm for determining the minimum distance between two surfaces is applied to estimate the tool size. The space between two blades that will be cleared from the roughcast is divided to generate CC points. The tool axis vector is confirmed based on flank milling using a simple method that could eliminate global interference between the tool and the blades. The result proves that the machining methodology presented in this paper is useful and successful.

  12. Polarized triple-axis spectrometer TASP

    Boeni, P.; Keller, P. [Lab. for Neutron Scattering ETH Zurich, Zurich (Switzerland) and Paul Scherrer Institute, Villigen (Switzerland)


    The polarized triple-axis spectrometer TASP at SINQ has been optimized for measuring magnetic cross sections in condensed matter. The neutrons are polarized or analyzed either by means of benders or Heusler monochromators. The beam divergence, i.e. the intensity, and the spectral range of the neutrons is rather large because of the supermirror coatings of the feeding neutron guide. The intensity can be further increased at the sample position by means of a focussing monochromator and a focussing anti-trumpet. The end position of TASP allows the tailoring of the neutron beam already before the monochromator and to scatter neutrons over very wide ranges of angles. (author) 6 figs., 1 tab., 8 refs.

  13. H3837 DARHT's first dual-axis shot

    Test H3837 was the first explosive shot performed in front of both flash x-ray axes at the Los Alamos Dual Axis Radiographic HydroTest (DARHT) facility. Executed in November 2009, the shot was an explosively-driven metal flyer plate in a series of experiments designed to explore equation-of-state properties of shocked materials. With high-strength steel walls over half an inch thick, the boom box confined the shot completely without taxing the penetrating capability of the DARHT x-ray beams; in addition, over three inches of tungsten attenuation in the beamlines prevented saturation of the camera systems. The boombox was staged within the DACS (Dual Axis Confinement system) with a source-to-object distance of 1.33 m for each Axis; radiographic magnifications were 4 and 4.5 for Axes I and II respectively. The first Axis provided a pulse of 60 ns width and dose 450 R at 1 m, while the second Axis provided four pulses of the following widths and doses: 20 ns, 85 R; 45 ns, 169 R; 65 ns, 233 R; 65 ns, 225 R; beam spot sizes were measured (50% MTF LANL definition) as < 1.7 mm (Axis I) and 1.9-2.8 mm (Axis II), with less than 1.5 mm beam motion between Axis II pulses. The Bucky Grid camera system was used for Axis I, while Axis II had a unique four-frame camera developed jointly by MIT Lincoln Laboratory. Imaging the initial shock wave traveling through the flyer plate, DARHT Axis II captured the range of motion from the shock front emergence in the flyer to breakout at the free surface; the Axis I pulse provided a perpendicular perspective of the shot at a time coinciding with the third pulse of Axis II. Shock speed in the material and other time-dependent properties such as material damage progression are measured using the time-evolved data from Axis II, while density reconstructions are made from the views of Axes I and II. The radiographs from Axis I and Axis II pulse 3 are compared in order to generate a three-dimensional image of the shocked material, enabling

  14. A comparison of on-axis and off-axis heliostat alignment strategies

    Jones, S.A.


    Heliostat installation and alignment costs will be an important element in future solar power tower projects. The predicted annual performances of on- and-off axis strategies are compared for 95 m{sup 2} flat-glass heliostats and an external, molten-salt receiver. Actual approaches to heliostat alignment that have been used in the past are briefly discussed, and relative strengths and limitations are noted. The optimal approach can vary with the application.

  15. Suicidal events among pathological gamblers: the role of comorbidity of axis I and axis II disorders.

    Bischof, Anja; Meyer, Christian; Bischof, Gallus; John, Ulrich; Wurst, Friedrich Martin; Thon, Natasha; Lucht, Michael; Grabe, Hans Joergen; Rumpf, Hans-Juergen


    The risk for suicidal ideation and suicide attempts among pathological gamblers is high compared to the general population. Little is known about the interplay of Axis I and Axis II disorders, severity of gambling disorder, and suicidal ideation and suicide attempts. The study aims to address this linkage. The sampling design of the study "Pathological Gambling and Epidemiology" (PAGE) included four recruitment channels: general population, gambling locations, project telephone hotline, and in-patient treatment for pathological gambling. A total of 442 study participants with lifetime pathological gambling received a clinical interview. The multivariate analysis showed mood disorders (Relative Risk Ratio, RRR=5.14, 95%-Confidence Interval, CI=2.91-9.07), substance use disorders (RRR=1.73, CI=1.02-2.94), and early onset of gambling disorder (RRR=0.96, CI=0.93-0.99) to be associated with suicidal ideation. Suicidal attempts were associated with female sex (RRR=3.58, CI=1.56-8.19), mood disorders (RRR=11.92, CI=4.70-30.26), and Cluster B personality disorders (RRR=2.40, CI=1.13-5.10). Among study participants with suicide attempts, more had a Cluster B personality disorder than among participants with ideation solely (RRR=3.08, CI=1.48-6.40). Among this large mixed sample of pathological gamblers, high proportions of individuals with suicidal events, multi-morbidity on Axis I, and a strong linkage to Cluster B personality disorders were found. PMID:25537488

  16. Iklan pada Provider AXIS dan TELKOMSEL di Televisi

    Simatupang, Perdana Tua


    Perdana Tua Simatupang. Communication Science. The title of the study is “AXIS and TELKOMSEL provider Television Commercial”. The goal of this study is to see the communication advertisement by AXIS and TELKOMSEL provider through television commercial. This study is using communication advertising theory and television commercial theory. Analysis used is single table data analysis and analytic hierarchy process(AHP). The object of the study is AXIS provider television commercial “Group Hug” v...

  17. Analysis and design of a vertical axis wind turbine

    Goyena Iriso, Joseba


    The main objective of this project is to design a new vertical axis wind turbine, specifically one Giromill wind turbine. The project development requires performing a previous study of the vertical axis wind turbines currently development. This study has to be performed before starting to design the wind turbine. Other very important aim is the development of a new vertical axis wind turbine. The after analyses that will result in the final design of the wind turbine will b...

  18. Energy Efficient Hybrid Dual Axis Solar Tracking System

    Rashid Ahammed Ferdaus; Mahir Asif Mohammed; Sanzidur Rahman; Sayedus Salehin; Mohammad Abdul Mannan


    This paper describes the design and implementation of an energy efficient solar tracking system from a normal mechanical single axis to a hybrid dual axis. For optimizing the solar tracking mechanism electromechanical systems were evolved through implementation of different evolutional algorithms and methodologies. To present the tracker, a hybrid dual-axis solar tracking system is designed, built, and tested based on both the solar map and light sensor based continuous tracking mechanism. Th...

  19. Semiactive Vibration Control for Horizontal Axis Washing Machine

    Barış Can Yalçın; Haluk Erol


    A semiactive vibration control method is developed to cope with the dynamic stability problem of a horizontal axis washing machine. This method is based on adjusting the maximum force values produced by the semiactive suspension elements considering a washing machine’s vibration data (three axis angular position and three axis angular acceleration values in time). Before actuation signals are received by the step motors of the friction dampers, vibration data are evaluated, and then, the step...

  20. The multi-axis vibration environment and man.

    Lovesey, E J


    Many investigations into the effects of vibration on man have been performed since Mallock's first study of London Underground vibrations in 1902. The vibration research has tended to be confined to the vertical (heave) axis, yet recent experiments have indicated that low frequency vibration along the lateral (sway) axis has a greater adverse effect upon comfort and performance. Measurements of the vibration environments in current forms of transport including motor vehicles, hovercraft and aircraft etc have shown that appreciable quantities of vibration along all three axes exist. Further vibration research should consider the effects of multi-axis vibrations upon man rather than limit tests to single axis vibration. PMID:15676336

  1. Neuroactive steroids and stress axis regulation: Pregnancy and beyond.

    Brunton, Paula J


    The hypothalamo-pituitary-adrenal (HPA) axis plays a critical role in regulating responses to stress and long term dysregulation of the HPA axis is associated with higher rates of mood disorders. There are circumstances where the HPA axis is more or less responsive to stress. For example, during late pregnancy ACTH and corticosterone responses to stress are markedly suppressed, whereas in offspring born to mothers that experienced repeated stress during pregnancy, the HPA axis is hyper-responsive to stress. Neuroactive steroids such as allopregnanolone, tetrahydrodeoxycorticosterone (THDOC) and androstanediol can modulate HPA axis activity and concentrations of some neuroactive steroids in the brain are altered during pregnancy and following stress. Thus, here altered neurosteroidogenesis is proposed as a mechanism that could underpin the dynamic changes in HPA axis regulation typically observed in late pregnant and in prenatally stressed individuals. In support of this hypothesis, evidence in rats demonstrates that elevated levels of allopregnanolone in pregnancy induce a central inhibitory opioid mechanism that serves to minimize stress-induced HPA axis activity. Conversely, in prenatally stressed rodents, where HPA axis stress responses are enhanced, evidence indicates the capacity of the brain for neurosteroidogenesis is reduced. Understanding the mechanisms involved in adaptations in HPA axis regulation may provide insights for manipulating stress sensitivity and for developing therapies for stress-related disorders in humans. PMID:26259885

  2. Comparison of long-axis and short-axis PROPELLER-EPI for diffusion-weighted magnetic resonance imaging; Vergleich von Long-Axis- und Short-Axis-PROPELLER-EPI fuer die diffusionsgewichtete Magnetresonanztomographie

    Rossbach, Matthias; Jochimsen, Thies H.; Herrmann, Karl-Heinz; Ros, Christian; Guellmar, Daniel; Reichenbach, Juergen R. [Jena Univ. Hospital (Germany). Medical Physics Group


    Echo planar imaging (EPI) in combination with PROPELLER allows high-resolution diffusion-weighted imaging. In this study, the image quality of short-axis and long-axis PROPELLER was compared and optimized using phantom and in vivo data. Furthermore, diffusion-weighted measurements using both sequences were compared with those of a reference sequence. It was found that the long-axis sequence provided better image quality, whereas the results of the diffusion weighted measurements were more accurate with the short-axis variant, and that the results of the diffusion weighted measurements of both sequences agreed well with those of the reference sequence. (orig.)

  3. Microbiota and the gut-brain axis.

    Bienenstock, John; Kunze, Wolfgang; Forsythe, Paul


    Changes in gut microbiota can modulate the peripheral and central nervous systems, resulting in altered brain functioning, and suggesting the existence of a microbiota gut-brain axis. Diet can also change the profile of gut microbiota and, thereby, behavior. Effects of bacteria on the nervous system cannot be disassociated from effects on the immune system since the two are in constant bidirectional communication. While the composition of the gut microbiota varies greatly among individuals, alterations to the balance and content of common gut microbes may affect the production of molecules such as neurotransmitters, e.g., gamma amino butyric acid, and the products of fermentation, e.g., the short chain fatty acids butyrate, propionate, and acetate. Short chain fatty acids, which are pleomorphic, especially butyrate, positively influence host metabolism by promoting glucose and energy homeostasis, regulating immune responses and epithelial cell growth, and promoting the functioning of the central and peripheral nervous systems. In the future, the composition, diversity, and function of specific probiotics, coupled with similar, more detailed knowledge about gut microbiota, will potentially help in developing more effective diet- and drug-based therapies. PMID:26175487

  4. Yaw dynamics of horizontal axis wind turbines

    Hansen, A. C.


    Designers of a horizontal axis wind turbine yaw mechanism are faced with a difficult decision. They know that if they elect to use a yaw-controlled rotor then the system will suffer increased initial cost and increased inherent maintenance and reliability problems. On the other hand, if they elect to allow the rotor to freely yaw they know they will have to account for unknown and random, though bounded, yaw rates. They will have a higher-risk design to trade-off against the potential for cost savings and reliability improvement. The risk of a yaw-free system could be minimized if methods were available for analyzing and understanding yaw behavior. The complexity of yaw behavior has, until recently, discouraged engineers from developing a complete yaw analysis method. The objectives of this work are to (1) provide a fundamental understanding of free-yaw mechanics and the design concepts most effective at eliminating yaw problems, and (2) provide tested design tools and guidelines for use by free-yaw wind systems manufacturers. The emphasis is on developing practical and sufficiently accurate design methods.

  5. Yaw dynamics of horizontal axis wind turbines

    Hansen, A.C. (Utah Univ., Salt Lake City, UT (United States))


    Designers of a horizontal axis wind turbine yaw mechanism are faced with a difficult decision. They know that if they elect to use a yaw- controlled rotor then the system will suffer increased initial cost and increased inherent maintenance and reliability problems. On the other hand, if they elect to allow the rotor to freely yaw they known they will have to account for unknown and random, though bounded, yaw rates. They will have a higher-risk design to trade-off against the potential for cost savings and reliability improvement. The risk of a yaw-free system could be minimized if methods were available for analyzing and understanding yaw behavior. The complexity of yaw behavior has, until recently, discouraged engineers from developing a complete yaw analysis method. The objectives of this work are to (1) provide a fundamental understanding of free-yaw mechanics and the design concepts most effective at eliminating yaw problems, and (2) provide tested design tools and guidelines for use by free-yaw wind systems manufacturers. The emphasis is on developing practical and sufficiently accurate design methods.

  6. Turbulence in vertical axis wind turbine canopies

    Kinzel, Matthias; Araya, Daniel B.; Dabiri, John O.


    Experimental results from three different full scale arrays of vertical-axis wind turbines (VAWTs) under natural wind conditions are presented. The wind velocities throughout the turbine arrays are measured using a portable meteorological tower with seven, vertically staggered, three-component ultrasonic anemometers. The power output of each turbine is recorded simultaneously. The comparison between the horizontal and vertical energy transport for the different turbine array sizes shows the importance of vertical transport for large array configurations. Quadrant-hole analysis is employed to gain a better understanding of the vertical energy transport at the top of the VAWT arrays. The results show a striking similarity between the flows in the VAWT arrays and the adjustment region of canopies. Namely, an increase in ejections and sweeps and decrease in inward and outward interactions occur inside the turbine array. Ejections are the strongest contributor, which is in agreement with the literature on evolving and sparse canopy flows. The influence of the turbine array size on the power output of the downstream turbines is examined by comparing a streamwise row of four single turbines with square arrays of nine turbine pairs. The results suggest that a new boundary layer forms on top of the larger turbine arrays as the flow adjusts to the new roughness length. This increases the turbulent energy transport over the whole planform area of the turbine array. By contrast, for the four single turbines, the vertical energy transport due to turbulent fluctuations is only increased in the near wake of the turbines. These findings add to the knowledge of energy transport in turbine arrays and therefore the optimization of the turbine spacing in wind farms.

  7. Gut-liver axis and sensing microbes.

    Szabo, Gyongyi; Bala, Shashi; Petrasek, Jan; Gattu, Arijeet


    'Detoxification' of gut-derived toxins and microbial products from gut-derived microbes is a major role of the liver. While the full repertoire of gut-derived microbial products that reach the liver in health and disease is yet to be explored, the levels of bacterial lipopolysaccharide (LPS), a component of Gram-negative bacteria, is increased in the portal and/or systemic circulation in several types of chronic liver diseases. Increased gut permeability and LPS play a role in alcoholic liver disease where alcohol impairs the gut epithelial integrity through alterations in tight junction proteins. In addition, non-alcoholic fatty liver disease is also associated with increased serum LPS levels and activation of the pro-inflammatory cascade plays a central role in disease progression. Microbial danger signals are recognized by pattern recognition receptors such as the Toll-like receptor 4 (TLR4). Increasing evidence suggests that TLR4-mediated signaling via the MyD88-dependent or MyD88-independent pathways may play different roles in liver diseases associated with increased LPS exposure of the liver as a result of gut permeability. For example, we showed that in alcoholic liver disease, the MyD88-independent, IRF3-dependent TLR4 cascade plays a role in steatosis and inflammation. Our recent data demonstrate that chronic alcohol exposure in the liver leads to sensitization of Kupffer cells to LPS via a mechanism involving upregulation of microRNA-155 in Kupffer cells. Thus, understanding the cell-specific recognition and intracellular signaling events in sensing gut-derived microbes will help to achieve an optimal balance in the gut-liver axis and ameliorate liver diseases. PMID:21525758

  8. Distortion definition and correction in off-axis systems

    Da Deppo, Vania; Simioni, Emanuele; Naletto, Giampiero; Cremonese, Gabriele


    Off-axis optical configurations are becoming more and more used in a variety of applications, in particular they are the most preferred solution for cameras devoted to Solar System planets and small bodies (i.e. asteroids and comets) study. Off-axis designs, being devoid of central obstruction, are able to guarantee better PSF and MTF performance, and thus higher contrast imaging capabilities with respect to classical on-axis designs. In particular they are suitable for observing extended targets with intrinsic low contrast features, or scenes where a high dynamical signal range is present. Classical distortion theory is able to well describe the performance of the on-axis systems, but it has to be adapted for the off-axis case. A proper way to deal with off-axis distortion definition is thus needed together with dedicated techniques to accurately measure and hence remove the distortion effects present in the acquired images. In this paper, a review of the distortion definition for off-axis systems will be given. In particular the method adopted by the authors to deal with the distortion related issues (definition, measure, removal) in some off-axis instruments will be described in detail.

  9. Angular momentum projection of tilted axis rotating states

    Oi, M.; Onishi, N.; Tajima, N. [Tokyo Univ. (Japan); Horibata, T.


    We applied an exact angular momentum projection to three dimensional cranked HFB (3d-CHFB) states. Tilted axis rotating states (TAR) and principal axis rotating states (PAR) are compared. It is shown that TAR is more adequate than PAR for description of the back bending phenomena driven by tilted rotation or wobbling motion. (author)

  10. A Method for Modeling of Floating Vertical Axis Wind Turbine

    Wang, Kai; Hansen, Martin Otto Laver; Moan, Torgeir


    It is of interest to investigate the potential advantages of floating vertical axis wind turbine (FVAWT) due to its economical installation and maintenance. A novel 5MW vertical axis wind turbine concept with a Darrieus rotor mounted on a semi-submersible support structure is proposed in this paper...

  11. Spin-stabilized magnetic levitation without vertical axis of rotation

    Romero, Louis; Christenson, Todd; Aaronson, Gene


    The symmetry properties of a magnetic levitation arrangement are exploited to produce spin-stabilized magnetic levitation without aligning the rotational axis of the rotor with the direction of the force of gravity. The rotation of the rotor stabilizes perturbations directed parallel to the rotational axis.

  12. Fracture modes in off-axis fiber composites

    Sinclair, J. H.; Chamis, C. C.


    Criteria have been developed for identifying, characterizing, and quantifying fracture modes in high-modulus graphite-fiber/resin unidirectional composites subjected to off-axis tensile loading. Procedures are described which use sensitivity analyses and off-axis data to determine the uniaxial strength of fiber composites. It was found that off-axis composites fail by three fracture modes which produce unique fracture surface characteristics. The stress that dominates each fracture mode and the load angle range of its dominance can be identified. Linear composite mechanics is adequate to describe quantitatively the mechanical behavior of off-axis composites. The uniaxial strengths predicted from off-axis data are comparable to those measured in uniaxial tests.

  13. Computational studies of horizontal axis wind turbines

    Xu, Guanpeng

    A numerical technique has been developed for efficiently simulating fully three-dimensional viscous fluid flow around horizontal axis wind turbines (HAWT) using a zonal approach. The flow field is viewed as a combination of viscous regions, inviscid regions and vortices. The method solves the costly unsteady Reynolds averaged Navier-Stokes (RANS) equations only in the viscous region around the turbine blades. It solves the full potential equation in the inviscid region where flow is irrotational and isentropic. The tip vortices are simulated using a Lagrangean approach, thus removing the need to accurately resolve them on a fine grid. The hybrid method is shown to provide good results with modest CPU resources. A full Navier-Stokes based methodology has also been developed for modeling wind turbines at high wind conditions where extensive stall may occur. An overset grid based version that can model rotor-tower interactions has been developed. Finally, a blade element theory based methodology has been developed for the purpose of developing improved tip loss models and stall delay models. The effects of turbulence are simulated using a zero equation eddy viscosity model, or a one equation Spalart-Allmaras model. Two transition models, one based on the Eppler's criterion, and the other based on Michel's criterion, have been developed and tested. The hybrid method has been extensively validated for axial wind conditions for three rotors---NREL Phase II, Phase III, and Phase VI configurations. A limited set of calculations has been done for rotors operating under yaw conditions. Preliminary simulations have also been carried out to assess the effects of the tower wake on the rotor. In most of these cases, satisfactory agreement has been obtained with measurements. Using the numerical results from present methodologies as a guide, Prandtl's tip loss model and Corrigan's stall delay model were correlated with present calculations. An improved tip loss model has been

  14. Notes on Mugger Crocodile Crocodylus palustris (Lesson, 1831) hunting on Axis axis in Bardia National Park, Nepal

    Bhattarai, Santosh


    Mugger Crocodile Crocodylus palustris is a specialized voracious predator. Hunting strategy of the Mugger on the Axis axis deer and food storing for later use behavior of Crocodylus palustris is documented in Bardia National Park, Nepal. Understanding the diet of the Mugger is of great significance in Bardia National Park for its conservation and management.

  15. Kinematic and Dynamic Analyses of the Orthoglide 5-axis

    Ur-Rehman, Raza; Chablat, Damien; Wenger, Philippe


    This paper deals with the kinematic and dynamic analyses of the Orthoglide 5-axis, a five-degree-of-freedom manipulator. It is derived from two manipulators: i) the Orthoglide 3-axis; a three dof translational manipulator and ii) the Agile eye; a parallel spherical wrist. First, the kinematic and dynamic models of the Orthoglide 5-axis are developed. The geometric and inertial parameters of the manipulator are determined by means of a CAD software. Then, the required motors performances are evaluated for some test trajectories. Finally, the motors are selected in the catalogue from the previous results.

  16. Design characteristics to reduce inadvertent cross-axis coupling during side stick handling of aircraft pitch and roll axis control

    Cote, Marie-Eve

    Integrating a manual flight control inceptor with coupled axes such as the side stick within a flight deck creates challenges for the pilot to input a one-axis command without inadvertently inducing inputs in the opposite axis. The present paper studies three design features of the side stick and armrest setup believed to help reduce inadvertent cross-axis coupling occurrences. Design features address the aimed pilot population anthropometry (1.57m woman to 1.9m male) and their variability in upper segment measurements. Seven pilots of varying anthropometric sizes were asked to perform one-axis manoeuvres in pitch and roll for each setup configuration. To compare the setups both the duration and the definite integral of the unintended cross-axis input were processed and analyzed for each manoeuvre. Findings show that a short armrest reduces the occurrences of cross-axis input for the roll manoeuvre, whereas the side stick skew reduces inadvertent cross-axis coupling for the pitch manoeuvres.

  17. Circular Interpolation Algorithms of 5-Axis Simultaneous CNC System

    ZHENG Kuijing; SHANG Bo


    Spatial circular arc can be machined conveniently by a 5-axis NC machine tool. Based on the data sampling method, circular interpolation in two-dimensional plane is discussed briefly. The key is to solve the problem of circular center expressed in the workpiece coordinate system by means of the transformation matrix. Circular interpolation in three-dimensional space is analyzed in detail. The method of undetermined coefficient is used to solve the center of the spatial circle and the method of coordinate transformation is used to transform the spatial circle into the XY_plane. Circular arc in three-dimensional space can be machined by the positional 5-axis machining and the conical surface can be machined by the continuous 5-axis machining. The velocity control is presented to avoid the feedrate fluctuation. The interpolation algorithms are tested by a simulation example and the interpolation algorithms are proved feasible. The algorithms are applied to the 5-axis CNC system software.

  18. Determination of Elastic Twist in Horizontal Axis Wind Turbines (HAWTs)

    Stoddard, F.; Nelson, V.; Starcher, K.; Andrews, B.


    This report presents the results of a project at the Alternative Energy Institute (AEI) which measured and calculated the elastic twist of three representative composite horizontal-axis blades: Carter 300, Gougeon ESI 54, and UTRC 8 kW.

  19. Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis.

    Handa, Robert J; Weiser, Michael J


    The hypothalamo-pituitary-adrenal (HPA) axis represents a complex neuroendocrine feedback loop controlling the secretion of adrenal glucocorticoid hormones. Central to its function is the paraventricular nucleus of the hypothalamus (PVN) where neurons expressing corticotropin releasing factor reside. These HPA motor neurons are a primary site of integration leading to graded endocrine responses to physical and psychological stressors. An important regulatory factor that must be considered, prior to generating an appropriate response is the animal's reproductive status. Thus, PVN neurons express androgen and estrogen receptors and receive input from sites that also express these receptors. Consequently, changes in reproduction and gonadal steroid levels modulate the stress response and this underlies sex differences in HPA axis function. This review examines the make up of the HPA axis and hypothalamo-pituitary-gonadal (HPG) axis and the interactions between the two that should be considered when exploring normal and pathological responses to environmental stressors. PMID:24246855

  20. The effects of lateral head tilt on ocular astigmatic axis

    Hamid Fesharaki


    Conclusion: Any minimal angle of head tilt may cause erroneous measurement of astigmatic axis and should be avoided during refraction. One cannot rely on the compensatory function of ocular counter-torsion during the refraction.

  1. Off-axis vortex breakdown in a shallow whirlpool

    Herrada, Miguel A.; Shtern, Vladimir N.; López-Herrera, José María


    The off-axis emergence of vortex breakdown (VB) is revealed. The steady axisymmetric flow in a vertical sealed cylinder, which is partially filled with water and the rest is filled with air, is driven by the rotating bottom disk. The numerical simulations show that VB can emerge away from the rotation axis, interface, and walls. As the rotation intensifies, VB first develops in the water region. If the water height is less (larger) than nearly one half of the cylinder radius, VB emerges off (on) the axis. As the rotation further increases, the off-axis VB ring touches the interface and then a thin countercirculation layer develops in the air flow above the water VB domain. This two-fluid VB ring shrinks (it even disappears in a very shallow whirlpool) as the interface approaches the bottom disk.

  2. Space/Flight Operable Miniature Six Axis Transducer Project

    National Aeronautics and Space Administration — FUTEK will fully design and manufacture a sensor capable of measuring forces in and about each axis. The unit will measure forces up to 300 Newton's in the...

  3. Proper time axis of a closed relativistic system

    The definition of a proper time axis of a closed relativistic system of colliding particles is given. The solution of the proper time axis problem is presented. If the light velocity c equals the imaginary unit i, then in the case of a plane motion of the system the problem about the proper time axis turns out to be equivalent to the known in engineering mechanics problem about the reduction of any system of forces, applied to a rigid body, to the dynamic screw. In the general case, when c=i, the problem about the proper time axis turns out to be equivalent to the problem about the reduction to the dynamic screw of a system of forces, applied to a rigid body in a four-dimensional Euclidean space

  4. Bucket-by-bucket on-axis/off-axis injection by fast kicker with variable position dependence of kick

    The bucket-by-bucket on-axis/off-axis injection system is proposed with new stripline fast kicker with variable position dependence of kick, from dipole to quadrupole, controlled by the drive voltage and its polarity. Applying the injection system to on-axis injection necessary for ultimate storage rings with narrow dynamic aperture, every bucket can be stored to achieve high average current with top-up operation. Also the minimum perturbation for stored beam can be achieved with the system by limiting the perturbations to injected bucket. Also the impurity electrons are prevented from injection with this system. (author)

  5. Vertical Axis Wind Turbines : Electrical System and Experimental Results

    Kjellin, Jon


    The wind power research at the division of Electricity at Uppsala University is aimed towards increased understanding of vertical axis wind turbines. The considered type of wind turbine is an H-rotor with a directly driven synchronous generator operating at variable speed. The experimental work presented in this thesis comprises investigation of three vertical axis wind turbines of different design and size. The electrical, control and measurement systems for the first 12 kW wind turbine have...

  6. Dynamic Compensation for Two-Axis Robot Wrist Force Sensors

    Junqing Ma; Aiguo Song; Dongcheng Pan


    To improve the dynamic characteristic of two-axis force sensors, a dynamic compensation method is proposed. The two-axis force sensor system is assumed to be a first-order system. The operation frequency of the system is expanded by a digital filter with backward difference network. To filter high-frequency noises, a low-pass filter is added after the dynamic compensation network. To avoid overcompensation, parameters of the proposed dynamic compensation method are defined by trial and error....

  7. MAP: Medial axis based geometric routing in sensor networks

    Bruck, Jehoshua; Gao, Jie; Jiang, Anxiao


    One of the challenging tasks in the deployment of dense wireless networks (like sensor networks) is in devising a routing scheme for node to node communication. Important consideration includes scalability, routing complexity, quality of communication paths and the load sharing of the routes. In this paper, we show that a compact and expressive abstraction of network connectivity by the medial axis enables efficient and localized routing. We propose MAP, a Medial Axis based naming and routing...

  8. The reno-pineal axis: A novel role for melatonin

    Sanjay Kalra


    Full Text Available The pineal gland is a tiny endocrine gland whose physiologic role has been the focus of much research and much more speculation over the past century. This mini-review discusses recent findings which correlate melatonin and renal physiology, and postulates the presence of a "reno-pineal axis." Drawing lessons from comparative endocrinology, while quoting human data, it advocates the need to study the "reno-pineal axis" in greater detail.

  9. The Post Processing Developing of Five-axis CNC Machine

    Anjiang Cai; Bin Li; Shihong Guo; Zhaoyang Dong


    In this study, we have a research of the methods of the special post processing program developing of Five-axis CNC machine DMC 70ev. On the basis of analysis about the characteristics of MILLPLUS IT V530 CNumerical control system, special post processor applied to five-axis CNC machining mode based on IMSPost was developed. Special post processing program developed was proved its accuracy and reliability by put it into practice. The research results has important significance for post proces...

  10. Axis I diagnostic comorbidity and borderline personality disorder.

    Zimmerman, M; Mattia, J I


    Borderline personality disorder (PD) has been the most studied PD. Research has examined the relationship between borderline PD and most axis I diagnostic classes such as eating disorders, mood disorders, and substance use disorders. However, there is little information regarding the relationship of borderline PD and overall comorbidity with all classes of axis I disorders assessed simultaneously. In the present study, 409 patients were evaluated with semistructured diagnostic interviews for axis I and axis II disorders. Patients with a diagnosis of borderline PD versus those who did not receive the diagnosis were assigned significantly more current axis I diagnoses (3.4 v 2.0). Borderline PD patients were twice as likely to receive a diagnosis of three or more current axis I disorders (69.5% v 31.1%) and nearly four times as likely to have a diagnosis of four or more disorders 147.5% v 13.7%). In comparison to nonborderline PD patients, borderline PD patients more frequently received a diagnosis of current major depressive disorder (MDD), bipolar I and II disorder, panic disorder with agoraphobia, social and specific phobia, posttraumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), eating disorder NOS, and any somatoform disorder. Similar results were observed for lifetime diagnoses. Overall, borderline PD patients were more likely to have multiple axis I disorders than nonborderline PD patients, and the differences between the two groups were present across mood, anxiety, substance use, eating, and somatoform disorder categories. These findings highlight the importance of performing thorough evaluations of axis I pathology in patients with borderline PD in order not to overlook syndromes that are potentially treatment-responsive. PMID:10428182

  11. Application of circulation controlled blades for vertical axis wind turbines

    Velissarios Kourkoulis; Andrew Shires


    The blades of a vertical axis wind turbine (VAWT) rotor see an inconsistent angle of attack through its rotation. Consequently, VAWT blades generally use symmetrical aerofoils with a lower lift-to-drag ratio than cambered aerofoils tailored to maximise horizontal axis wind turbine rotor performance. This paper considers the feasibility of circulation controlled (CC) VAWT blades, using a tangential air jet to provide lift and therefore power augmentation. However CC blade sections require a hi...

  12. Rotation axis demultiplexer enabling simultaneous computed tomography of multiple samples

    Trtik, Pavel; Geiger, Fabian; Hovind, Jan; Lang, Udo; Lehmann, Eberhard; Vontobel, Peter; Peetermans, Steven


    This paper describes a device that allows for simultaneous tomographic imaging of samples on three independent rotational axes. This rotation axis demultiplexer (POLYTOM) is equipped with anti-backlash gears and placed on a standard sample rotation stage thus allowing for the transformation of the input rotation axis onto two additional parallel vertical axes. Consequently, three times the number of samples can be investigated within a given time period, thereby reducing the acquisition time ...

  13. Vertical Axis Wind Turbines : Tower Dynamics and Noise

    Möllerström, Erik


    Vertical axis wind turbines (VAWTs) have with time been outrivaled by the today common and economically feasible horizontal axis wind turbines (HAWTs). However, VAWTs have several advantages such as the possibility to put the drive train at ground level, lower noise emissions and better scaling behavior which still make them interesting for research. The work within this thesis is made in collaboration between the Department of Construction and Energy Engineering at Halmstad University and th...

  14. Small Vertical Axis Wind Turbines: aerodynamics and starting behavior

    Dumitrescu, Horia; Vladimir CARDOS; Radu BOGATEANU


    In urban areas the wind is very turbulent and unstable with fast changes in direction andvelocity. In these environments, the use of small vertical axis wind turbines (VAWT) becomesincreasingly attractive due to several advantages over horizontal axis wind turbines (HAWT).However, such designs have received much less attention than the more common propeller-typedesigns and the understanding of same aspects of their operation remains, to this day, incomplete.This is particularly true of their ...

  15. Experimental study of the subtalar joint axis: preliminary investigation.

    Zographos, S; Chaminade, B; Hobatho, M C; Utheza, G


    An experimental study of the subtalar joint has been conducted with the aim of establishing its axis of movement as well as analysing the associated movement. For description of the axis, CT data for five positions of a single foot were reconstructed using a 3D programme, the 3D data was processed by Patran software. Measures of angular displacements were made from three amputated feet placed in a specially constructed foot frame. Four instantaneous axes of movement could be defined. Calculation of displacements showed an important rolling of the calcaneus (45 degrees). Tacking was evident in inversion, with an opposite displacement between the front and rear part of the calcaneus, whereas during eversion tacking affected only the rear part of the bone: these results were confirmed by 3D reconstructions. Henke's axis was described as that for the talonavicular joint, but acceptable for the subtalar joint. Several authors investigating the coordinates of this axis have reported large differences and described screw-like movements, the latter being incompatible with a fixed axis: instantaneous axes, however are compatible with a screw-like movement. The subtalar joint appears to work as a pivot joint during inversion and as a plane joint during eversion. Although Henke's axis has pedagogical value the subtalar joint has a series of instantaneous axes. PMID:11236321

  16. Major and minor axis kinematics of 22 ellipticals

    Franx, Marijn; Illingworth, Garth; Heckman, Timothy


    Rotation curves and velocity dispersion profiles have been determined for the major and the minor axes of 22 elliptical galaxies. Rotation was detected in all but one galaxy, even though the sample was biased toward round ellipticals. Minor axis rotation larger than major axis rotation was measured in two galaxies, NGC 4406 and NGC 7507. Roughly 10 percent of ellipticals may show large minor axis velocities relative to those on the major axis. A simple model is used to derive a rotational axis from the observed minor and major axis velocities to a typical accuracy of 6 deg. The rotational and photometric minor axes aligned to better than 10 deg for 60 percent of the sample, implying that the direction of the angular momentum is related to the orientation of the figure of the galaxy. IC 1459 has a kinematically distinct core with its angular momentum opposite to the angular momentum of the outer parts, and NGC 4406 has a core with its angular momentum perpendicular to that of the outer parts.

  17. Celiac axis stenosis and lethal liver ischemia after pancreaticoduodenectomy.

    Lipska, Ludmila; Visokai, Vladimir; Levy, Miroslav; Koznar, Boris; Zaruba, Pavel


    Celiac axis stenosis can lead to a fatal hepatic ischemia after pancreaticoduodenectomy unless a simultaneous revascularisation of the celiac circulation is performed. In the present study are reported three cases of celiac axis stenosis, all of which had histologically confirmed periampullary cancer. Case 1: a 50-year-old male with a history of myocardial infarction and liver steatosis; visceral arteriography prior to the surgery demonstrated a celiac axis stenosis. Whipple operation was performed. After removing the specimen, no signs of liver ischemia were found (liver was cholestatic) and pulsation of the hepatic artery was strong. The patient died on the second postoperative day after an abrupt irreversible cardiac arrest. Autopsy proved acute severe hepatic ischemia. Case 2: a 64-year-old female. Preoperative visceral angiography showed significant celiac axis stenosis. As a first step of surgery the root of the celiac trunk was exposed, a fibrotic ring around it was divided. Standard D1 pylorus preserving pancreaticoduodenectomy was performed. Case 3: a 58-year-old female without preoperative angiography, indicated for surgery. After an occlusion test of the gastroduodenal artery the liver became ischemic. Division of the fibrotic ring around celiac axis was performed together with a standard D1 pylorus preserving pancreaticoduodenectomy. No postoperative complications were reported in both case 2 and 3. PMID:19760970

  18. Off-axis angular spectrum method with variable sampling interval

    Kim, Yong-Hae; Byun, Chun-Won; Oh, Himchan; Pi, Jae-Eun; Choi, Ji-Hun; Kim, Gi Heon; Lee, Myung-Lae; Ryu, Hojun; Hwang, Chi-Sun


    We proposed a novel off-axis angular spectrum method (ASM) for simulating free space wave propagation with a large shifted destination plane. The off-axis numerical simulation took wave propagation between a parallel source and a destination plane, but a destination plane was shifted from a source plane. The shifted angular spectrum method was proposed for diffraction simulation with a shifted destination plane and satisfied the Nyquist condition for sampling by limiting a bandwidth of a propagation field to avoid an aliasing error due to under sampling. However, the effective sampling number of the shifted ASM decreased when the shifted distance of the destination plane was large which caused a numerical error in the diffraction simulation. To compensate for the decrease of an effective sampling number for the large shifted destination plane, we used a variable sampling interval in a Fourier space to maintain the same effective sampling number independent of the shifted distance of the destination plane. As a result, our proposed off-axis ASM with a variable sampling interval can produce simulation results with high accuracy for nearly every shifted distance of a destination plane when an off-axis angle is less than 75°. We compared the performances of the off-axis ASM using the Chirp Z transform and non-uniform FFT for implementing a variable spatial frequency in a Fourier space.

  19. An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension

    Anderson, Matthew J.; Schimmang, Thomas; Lewandoski, Mark


    During vertebrate axis extension, adjacent tissue layers undergo profound morphological changes: within the neuroepithelium, neural tube closure and neural crest formation are occurring, while within the paraxial mesoderm somites are segmenting from the presomitic mesoderm (PSM). Little is known about the signals between these tissues that regulate their coordinated morphogenesis. Here, we analyze the posterior axis truncation of mouse Fgf3 null homozygotes and demonstrate that the earliest role of PSM-derived FGF3 is to regulate BMP signals in the adjacent neuroepithelium. FGF3 loss causes elevated BMP signals leading to increased neuroepithelium proliferation, delay in neural tube closure and premature neural crest specification. We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist. In such mutants, all parameters of the Fgf3 phenotype were exacerbated: neural tube closure delay, premature neural crest specification, and premature axis termination. Conversely, genetically decreasing BMP signaling in Fgf3 mutants, via loss of BMP receptor activity, alleviates morphological defects. Aberrant apoptosis is observed in the Fgf3 mutant tailbud. However, we demonstrate that cell death does not cause the Fgf3 phenotype: blocking apoptosis via deletion of pro-apoptotic genes surprisingly increases all Fgf3 defects including causing spina bifida. We demonstrate that this counterintuitive consequence of blocking apoptosis is caused by the increased survival of BMP-producing cells in the neuroepithelium. Thus, we show that FGF3 in the caudal vertebrate embryo regulates BMP signaling in the neuroepithelium, which in turn regulates neural tube closure, neural crest specification and axis termination. Uncovering this FGF3-BMP signaling axis is

  20. An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension.

    Matthew J Anderson


    Full Text Available During vertebrate axis extension, adjacent tissue layers undergo profound morphological changes: within the neuroepithelium, neural tube closure and neural crest formation are occurring, while within the paraxial mesoderm somites are segmenting from the presomitic mesoderm (PSM. Little is known about the signals between these tissues that regulate their coordinated morphogenesis. Here, we analyze the posterior axis truncation of mouse Fgf3 null homozygotes and demonstrate that the earliest role of PSM-derived FGF3 is to regulate BMP signals in the adjacent neuroepithelium. FGF3 loss causes elevated BMP signals leading to increased neuroepithelium proliferation, delay in neural tube closure and premature neural crest specification. We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist. In such mutants, all parameters of the Fgf3 phenotype were exacerbated: neural tube closure delay, premature neural crest specification, and premature axis termination. Conversely, genetically decreasing BMP signaling in Fgf3 mutants, via loss of BMP receptor activity, alleviates morphological defects. Aberrant apoptosis is observed in the Fgf3 mutant tailbud. However, we demonstrate that cell death does not cause the Fgf3 phenotype: blocking apoptosis via deletion of pro-apoptotic genes surprisingly increases all Fgf3 defects including causing spina bifida. We demonstrate that this counterintuitive consequence of blocking apoptosis is caused by the increased survival of BMP-producing cells in the neuroepithelium. Thus, we show that FGF3 in the caudal vertebrate embryo regulates BMP signaling in the neuroepithelium, which in turn regulates neural tube closure, neural crest specification and axis termination. Uncovering this FGF3

  1. 艾灸对血管性痴呆大鼠海马内VEGF、flt-1、bFGF及bFGF-r表达的影响%Effects of Moxibustion on the Expressions of Hlppocampal VEGF, fit-1, bFGF, and bFGF-r in Vascular

    王频; 汤敬一; 杨骏; 张庆萍


    Objective To observe the expression levels of hippocampal vascular endothelial growth factor (VEGF), fms-like tyrosine kinase-1 (flt-1), basic fibroblast growth factor (bFGF), and basic fibroblast growth factor receptor (bFGF-r) in vascular dementia (VD) rats, thus studying the angiogenesis mechanism of moxi-bustion in VD. Methods Sixty male elderly Wistar rats were selected. The VD rat model was prepared by bilateral carotid artery occlusion and reperfusion of sodium nitroprusside injection. The model rats were divided into 3 groups by the random digit table, I. E., the moxibustion group, the Western medicine group, and the model group. A sham-operation control group was also set up. In the moxibustion group rats was acupunctured at Baihui (GV20), Shenting (GV14), and Dazhui (GV24). Aniracetam was given to rats in the Western medicine group by gastrogavage for 2 therapeutic courses, 15 days as one course. The learning and memory results were observed by the neuroethological score in combination of step-down avoidance test before treatment and by the end of the 2nd course respectively. The expression levels of hippocampal VEGF, flt-1, bFGF, and bFGF-r of allrats were detected using immunohistochemical assay. Results After 2 courses of treatment, statistical difference existed in the latent period, the error times, and the neuroethological score in the moxibustion group and the Western medicine group when compared with the model group (P<0.01, P<0. 05). Statistical difference existed in the latent period and the neuroethological score between the moxibustion group and the Western medicine group (P<0. 05), which indicated that moxibustion and Western medicine showed significant effects in improving the latent period, decreasing the error times and the neuroethological score. Better results were obtained in the moxibustion group than in the Western medicine group (P<0. 01, P<0. 05). Statistical difference of the average grey level (AGL) of hippocampal VEGF, flt-1, and

  2. Emergence of principal axis rotation in 110Ag

    The negative-parity yrast band of 110Ag has been extended significantly and the lifetimes of the high spin levels of this band have been measured. The experimentally observed level scheme and measured electromagnetic transition rates have been compared with the theoretical predictions of a model with two quasiparticles coupled to a triaxially deformed core. This calculation successfully reproduces the energy spectra and electromagnetic transition rates beyond Iπ=12-ℏ. These observations indicate that the principal axis of rotation is responsible for the generation of high angular momentum states along the yrast cascade in 110Ag. In all the other lighter isotopes, these states are generated through titled axis rotation. Thus, 110Ag is the first nucleus where the boundary between tilted and principal axis rotation could be established.

  3. Central configurations of four bodies with an axis of symmetry

    Érdi, Bálint; Czirják, Zalán


    A complete solution is given for a symmetric case of the problem of the planar central configurations of four bodies, when two bodies are on an axis of symmetry, and the other two bodies have equal masses and are situated symmetrically with respect to the axis of symmetry. The positions of the bodies on the axis of symmetry are described by angle coordinates with respect to the outside bodies. The solution is such, that giving the angle coordinates, the masses for which the given configuration is a central configuration, can be computed from simple analytical expressions of the angles. The central configurations can be described as one-parameter families, and these are discussed in detail in one convex and two concave cases. The derived formulae represent exact analytical solutions of the four-body problem.

  4. Role of Met Axis in Head and Neck Cancer

    Xu, Yiru, E-mail:; Fisher, Gary J., E-mail: [Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 (United States)


    Head and neck cancer is the sixth most common type of cancer worldwide. Despite advances in aggressive multidisciplinary treatments, the 5-year survival rate for this dreadful disease is only 50%, mostly due to high rate of recurrence and early involvement of regional lymph nodes and subsequent metastasis. Understanding the molecular mechanisms responsible for invasion and metastasis is one of the most pressing goals in the field of head and neck cancer. Met, also known as hepatocyte growth factor receptor (HGFR), is a member of the receptor protein tyrosine kinase (RPTK) family. There is compelling evidence that Met axis is dysregulated and plays important roles in tumorigenesis, progression, metastasis, angiogenesis, and drug resistance in head and neck cancer. We describe in this review current understanding of Met axis in head and neck cancer biology and development of therapeutic inhibitors targeting Met axis.

  5. Microwave Bragg-scattering zone-axis-pattern analysis

    Fraundorf, P; Garver, W; Freeman, M; Proctor, D


    Louis deBroglie's connection between momentum and spatial-frequency vectors is perhaps most viscerally-experienced via the real-time access that electron-diffraction provides to transverse slices of a crystal's reciprocal lattice. The classic introductory (and/or advanced) physics lab-experiment on microwave Bragg-scattering can with a bit of re-arrangement also give students access to "zone-axis-pattern" slices through the 3D spatial-frequency (i.e. reciprocal) lattice of a ball-bearing crystal. In this paper we show how data from the standard experimental set up can be used to generate zone-axis-patterns oriented down the crystal rotation-axis. This may be used to give students direct experience with crystal shape-transforms (which help to explain anomalous peaks), as well as to the complementary relation between non-Cartesian basis-vectors in direct and reciprocal (co-vector) space.

  6. The Minimal Model of the Hypothalamic-Pituitary-Adrenal Axis

    Vinther, Frank; Andersen, Morten; Ottesen, Johnny T.


    This paper concerns ODE modeling of the hypothalamic-pituitary-adrenalaxis (HPA axis) using an analytical and numerical approach, combined with biological knowledge regarding physiological mechanisms and parameters. The three hormones, CRH, ACTH, and cortisol, which interact in the HPA axis are...... modeled as a system of three coupled, nonlinear differential equations. Experimental data shows the circadian as well as the ultradian rhythm. This paper focuses on the ultradian rhythm. The ultradian rhythm can mathematically be explained by oscillating solutions. Oscillating solutions to an ODE emerges...... from an unstable fixed point with complex eigenvalues with a positive real parts and a non-zero imaginary parts. The first part of the paper describes the general considerations to be obeyed for a mathematical model of the HPA axis. In this paper we only include the most widely accepted mechanisms that...

  7. Small Vertical Axis Wind Turbines: aerodynamics and starting behavior



    Full Text Available In urban areas the wind is very turbulent and unstable with fast changes in direction andvelocity. In these environments, the use of small vertical axis wind turbines (VAWT becomesincreasingly attractive due to several advantages over horizontal axis wind turbines (HAWT.However, such designs have received much less attention than the more common propeller-typedesigns and the understanding of same aspects of their operation remains, to this day, incomplete.This is particularly true of their starting characteristics. Indeed, same authors heuristically maintainthat they cannot start without external assistance. This paper reviews the cause of the inability of thelow solidity fixed pitch vertical axis wind turbines to self-start, and investigates the way ofovercoming this draw back.

  8. Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints

    Grigory Genikhovich


    Full Text Available BMP signaling plays a crucial role in the establishment of the dorso-ventral body axis in bilaterally symmetric animals. However, the topologies of the bone morphogenetic protein (BMP signaling networks vary drastically in different animal groups, raising questions about the evolutionary constraints and evolvability of BMP signaling systems. Using loss-of-function analysis and mathematical modeling, we show that two signaling centers expressing different BMPs and BMP antagonists maintain the secondary axis of the sea anemone Nematostella. We demonstrate that BMP signaling is required for asymmetric Hox gene expression and mesentery formation. Computational analysis reveals that network parameters related to BMP4 and Chordin are constrained both in Nematostella and Xenopus, while those describing the BMP signaling modulators can vary significantly. Notably, only chordin, but not bmp4 expression needs to be spatially restricted for robust signaling gradient formation. Our data provide an explanation of the evolvability of BMP signaling systems in axis formation throughout Eumetazoa.

  9. Observation of equilibria with a double magnetic axis in LHD

    Plasma shape control is a major knob to investigate confinement as well as MHD characteristics of magnetically confined plasmas. LHD has a large flexibility to explore a configuration effect by using 6 independent coil systems. Elongation can be controlled by a quadrupole field. Experimental observation of moderate elongation has shown that confinement is degraded gradually in both prolate (vertically elongated) and oblate (horizontally elongated) configurations. Since the rotational transform is weaker in the core region than in the periphery in LHD, a theoretical analysis suggests that excess quadrupole field results in split of the magnetic axis. Then the internal separatrix like petals emerges. Further application of quadrupole field eventually realizes a doublet configuration with a double magnetic axis bounded by this separatrix. An analytics suggests that split of the magnetic axis starts beyond elongation κ of 1.6 in the prolate case. The role of separatrix is attracting interest in effect on confinement performance as well as physics of unstable manifold, which has motivated strong shaping experiment in LHD. Both shaping of prolate and oblate directions has been explored for NBI heated plasmas. In the strongly prolate case, the doublet image has been observed by a tangential soft X-ray camera. Available profile measurements of temperature and density have not provided the 2-dimensional profile, however, assumption of concentric surfaces with a single magnetic axis seems to contradict with experimental observations in the 1-dimensional measurements in the case with strong shaping. This suggests the existence of doublet magnetic surfaces. These complex equilibria cannot be treated by the numerical code, ex. VMEC, with an assumption of nested flux surfaces with a single magnetic axis. Characteristics of these eccentric equilibria have been investigated by the HINT code which does not assume existence of nested flux surfaces. Experimental and computational

  10. Calibration of three-axis magnetometers with differential evolution algorithm

    The accuracy of three-axis magnetometers is influenced by different scale and bias of each axis and nonorthogonality between axes. One limitation of traditional iteration methods is that initial parameters influence the calibration, thus leading to the local optimal or wrong results. In this paper, a new method is proposed to calibrate three-axis magnetometers. To employ this method, a nonmagnetic rotation platform, a proton magnetometer, a DM-050 three-axis magnetometer and the differential evolution (DE) algorithm are used. The performance of this calibration method is analyzed with simulation and experiment. In simulation, the calibration results of DE, unscented Kalman filter (UKF), recursive least squares (RLS) and genetic algorithm (GA) are compared. RMS error using DE is least, which is reduced from 81.233 nT to 1.567 nT. Experimental results show that comparing with UKF, RLS and GA, the DE algorithm has not only the least calibration error but also the best robustness. After calibration, RMS error is reduced from 68.914 nT to 2.919 nT. In addition, the DE algorithm is not sensitive to initial parameters, which is an important advantage compared with traditional iteration algorithms. The proposed algorithm can avoid the troublesome procedure to select suitable initial parameters, thus it can improve the calibration performance of three-axis magnetometers. - Highlights: • The calibration results and robustness of UKF, GA, RLS and DE algorithm are analyzed. Calibration error of DE is the least in simulation and experiment. • Comparing with traditional calibration algorithms, DE is not sensitive to initial parameters. • It can improve the calibration performance of three-axis magnetometers

  11. Spin-axis pointing of a magnetically actuated spacecraft

    Avanzini, G.; de Angelis, E. L.; Giulietti, F.


    Attitude regulation proves to be a challenging problem, when magnetic actuators alone are used as attitude effectors, since they do not provide three independent control torque components at each time instant. In this paper a rigorous proof of global exponential stability is derived for a magnetic control law that leads the satellite to a desired spin condition around a principal axis of inertia, pointing the spin axis toward a prescribed direction in the inertial frame. The technique is demonstrated by means of numerical simulation of a few example maneuvers. An extensive Monte Carlo simulation is performed for random initial conditions, in order to investigate the effect of changes in control law gains.

  12. Efficient Path Query and Reasoning Method Based on Rare Axis

    姜洋; 冯志勇; 王鑫马晓宁


    A new concept of rare axis based on statistical facts is proposed, and an evaluation algorithm is designed thereafter. For the nested regular expressions containing rare axes, the proposed algorithm can reduce its evaluation complexity from polynomial time to nearly linear time. The distributed technique is also employed to construct the navigation axis indexes for resource description framework (RDF) graph data. Experiment results in DrugBank and BioGRID show that this method can improve the query efficiency significantly while ensuring the accuracy and meet the query requirements on Web-scale RDF graph data.

  13. Fluctuation of electromagnetic cascade axis in dense amorphous segmented media

    The investigation of fluctuation of the so-called energy cascade axis around the geometry cascade axis for electromagnetic cascade produced in liquid xenon by gamma quanta within the energy interval 100-3500 MeV has been performed. As a basis the previously obtained experimental data from the 180- liter Xenon Bubble Chamber of ITEP were use. Our results may be helpful for the construction and further to improve the characteristics of electromagnetic calorimeters with fine-segmented active absorbers such as PANDA (GSI, Darmstardt) and SPHERE (LHE, JINR, Dubna)

  14. Three axis vector atomic magnetometer utilizing polarimetric technique

    Pradhan, Swarupananda


    The three axis magnetic field measurement based on the interaction of a single elliptically polarized light beam with an atomic system is described. The magnetic field direction dependent atomic responses are extracted by the polarimetric detection in combination with laser frequency modulation and magnetic field modulation techniques. The magnetometer offers additional critical requirements like compact size and large dynamic range for space application. Further, the three axis magnetic field is measured using only reflected signal from the polarimeter, thus can be easily expanded to make spatial array of detectors or / and high sensitivity field gradient measurement as required for biomedical application.


    Saxer, M.


    Full Text Available In the modern metalworking industry, production moulds often have complex geometry, with undercut regions, small corner radii, sharp edges, deep cavities, or large cores. Conventional manufacturing process chains to machine these complex features are often lengthy and inefficient due to multiple steps. This article presents current results obtained through industry projects and experimental work using 5-axis high-speed machining with high-end CAD/CAM systems to improve process efficiency. Cost optimisation and lead time shortening can be clearly shown. This is of particular importance for South African manufacturing companies, where multi-axis HSC technology although not totally unknown is significantly under-used.

  16. Single Vector Calibration System for Multi-Axis Load Cells and Method for Calibrating a Multi-Axis Load Cell

    Parker, Peter A. (Inventor)


    A single vector calibration system is provided which facilitates the calibration of multi-axis load cells, including wind tunnel force balances. The single vector system provides the capability to calibrate a multi-axis load cell using a single directional load, for example loading solely in the gravitational direction. The system manipulates the load cell in three-dimensional space, while keeping the uni-directional calibration load aligned. The use of a single vector calibration load reduces the set-up time for the multi-axis load combinations needed to generate a complete calibration mathematical model. The system also reduces load application inaccuracies caused by the conventional requirement to generate multiple force vectors. The simplicity of the system reduces calibration time and cost, while simultaneously increasing calibration accuracy.

  17. An improved computer controlled triple-axis neutron spectrometer

    A description is given of the computer-controlled triple-axis neutron spectrometer installed at the PLUTO reactor at Harwell. The reasons for an nature of recent major improvements are discussed. Following a general description of the spectrometer, details are then given of the new computerised control system, including the functions of the various programs which are now available to the user. (author)

  18. Brain-gut-microbiota axis in Parkinson's disease.

    Mulak, Agata; Bonaz, Bruno


    Parkinson's disease (PD) is characterized by alpha-synucleinopathy that affects all levels of the brain-gut axis including the central, autonomic, and enteric nervous systems. Recently, it has been recognized that the brain-gut axis interactions are significantly modulated by the gut microbiota via immunological, neuroendocrine, and direct neural mechanisms. Dysregulation of the brain-gut-microbiota axis in PD may be associated with gastrointestinal manifestations frequently preceding motor symptoms, as well as with the pathogenesis of PD itself, supporting the hypothesis that the pathological process is spread from the gut to the brain. Excessive stimulation of the innate immune system resulting from gut dysbiosis and/or small intestinal bacterial overgrowth and increased intestinal permeability may induce systemic inflammation, while activation of enteric neurons and enteric glial cells may contribute to the initiation of alpha-synuclein misfolding. Additionally, the adaptive immune system may be disturbed by bacterial proteins cross-reacting with human antigens. A better understanding of the brain-gut-microbiota axis interactions should bring a new insight in the pathophysiology of PD and permit an earlier diagnosis with a focus on peripheral biomarkers within the enteric nervous system. Novel therapeutic options aimed at modifying the gut microbiota composition and enhancing the intestinal epithelial barrier integrity in PD patients could influence the initial step of the following cascade of neurodegeneration in PD. PMID:26457021

  19. Cellulose and the twofold screw axis: Modeling and experimental arguments

    Crystallography indicates that molecules in crystalline cellulose either have 2-fold screw-axis (21) symmetry or closely approximate it, leading to short distances between H4 and H1' across the glycosidic linkage. Therefore, modeling studies of cellobiose often show elevated energies for 21 structur...

  20. Contribution to the method for determining femoral neck axis

    Anđelković Zoran


    Full Text Available Introduction. Femoral neck axis plotting is of great significance in measuring parameters that define femoral head-neck junction sphericity in the group of patients with the femoroacetabular impingement. Literature methods of femoral neck axis determination have weaknesses associated with the risk of obtaining inaccurate values of certain parameters. Objective. Method of plotting of the femoral neck axis by two parallel lines that belong to the medial quarter of the femoral neck is proposed. Method was tested on the anatomic specimens and the respective radiograms. Methods. A total of 31 anatomic specimens of the proximal femur and respective radiographs were used, on which three axes of the femoral neck were plotted; accordingly, alpha angle value was determined and tested with corresponding parametric tests, with the measurement error of less than 5% and the strength of the applied tests of 80%. Results. Alpha angle values obtained by plotting femoral neck axis using the literature and methods we have proposed were not significantly different in our series, and, in more than a half of the specimens, the two axes overlapped each other. Conclusion. The advantage of the proposed method does not depend on the position of the femoral head rotation center in relation to the femoral neck, which favors proposed method for measuring the angles of femoral head sphericity in patients with the femoral head translation. Disadvantage of the study is a small sample size for valid conclusions about the applicability of this method in clinical practice.

  1. Survey of Unsteady Computational Aerodynamics for Horizontal Axis Wind Turbines

    Frunzulicǎ, F.; Dumitrescu, H.; Cardoş, V.


    We present a short review of aerodynamic computational models for horizontal axis wind turbines (HAWT). Models presented have a various level of complexity to calculate aerodynamic loads on rotor of HAWT, starting with the simplest blade element momentum (BEM) and ending with the complex model of Navier-Stokes equations. Also, we present some computational aspects of these models.

  2. Stereo PIV Experiments on Horizontal Axis Wind Turbine Rotor Model

    Akay, B.; Micallef, D.; Ferreira, C.S.; Van Bussel, G.J.W.


    This paper sets out to describe the measurements and computations to construct three components of velocity field around the blade. The primary aim of the measurements was to gain insight into the physics of the flow field produced by a horizontal axis wind turbine-HAWT blade. Stereo Particle Image

  3. On the Turbulent Mixing in Horizontal Axis Wind Turbine Wakes

    Lignarolo, L.E.M.


    The wake flow of a horizontal axis wind turbine is characterised by lower wind speed and higher turbulence than the free-stream conditions. When clustered in large wind farms, wind turbines regularly operate inside the wake of one or more upstream machines. This is a major cause of energy production

  4. Spin fluids in stationary axis-symmetric space-times

    The relations establishing the equivalence of an ordinary perfect fluid stress-energy tensor and a spin fluid stress-energy tensor are derived for stationary axis-symmetric space-times in general relativity. Spin fluid sources for the Goedel cosmology and the van Stockum metric are given

  5. Spin fluids in stationary axis-symmetric space-times

    Krisch, J. P.


    The relations establishing the equivalence of an ordinary perfect fluid stress-energy tensor and a spin fluid stress-energy tensor are derived for stationary axis-symmetric space-times in general relativity. Spin fluid sources for the Gödel cosmology and the van Stockum metric are given.

  6. Tilted axis rotation in odd-odd {sup 164}Tm

    Reviol, W.; Riedinger, L.L.; Wang, X.Z.; Zhang, J.Y. [Univ. of Tennessee, Knoxville, TN (United States)] [and others


    Ten band structures are observed in {sup 164}Tm, among them sets of parallel and anti-parallel couplings of the proton and neutron spins. The Tilted Axis Cranking scheme is applied for the first time to an odd-odd nucleus in a prominent region of nuclear deformation.

  7. Analytical Aerodynamic Simulation Tools for Vertical Axis Wind Turbines

    Wind power is a renewable energy source that is today the fastest growing solution to reduce CO2 emissions in the electric energy mix. Upwind horizontal axis wind turbine with three blades has been the preferred technical choice for more than two decades. This horizontal axis concept is today widely leading the market. The current PhD thesis will cover an alternative type of wind turbine with straight blades and rotating along the vertical axis. A brief overview of the main differences between the horizontal and vertical axis concept has been made. However the main focus of this thesis is the aerodynamics of the wind turbine blades. Making aerodynamically efficient turbines starts with efficient blades. Making efficient blades requires a good understanding of the physical phenomena and effective simulations tools to model them. The specific aerodynamics for straight bladed vertical axis turbine flow are reviewed together with the standard aerodynamic simulations tools that have been used in the past by blade and rotor designer. A reasonably fast (regarding computer power) and accurate (regarding comparison with experimental results) simulation method was still lacking in the field prior to the current work. This thesis aims at designing such a method. Analytical methods can be used to model complex flow if the geometry is simple. Therefore, a conformal mapping method is derived to transform any set of section into a set of standard circles. Then analytical procedures are generalized to simulate moving multibody sections in the complex vertical flows and forces experienced by the blades. Finally the fast semi analytical aerodynamic algorithm boosted by fast multipole methods to handle high number of vortices is coupled with a simple structural model of the rotor to investigate potential aeroelastic instabilities. Together with these advanced simulation tools, a standard double multiple streamtube model has been developed and used to design several straight bladed

  8. DARHT Axis-I Diode Simulations II: Geometrical Scaling

    Ekdahl, Carl A. Jr. [Los Alamos National Laboratory


    Flash radiography of large hydrodynamic experiments driven by high explosives is a venerable diagnostic technique in use at many laboratories. Many of the largest hydrodynamic experiments study mockups of nuclear weapons, and are often called hydrotests for short. The dual-axis radiography for hydrodynamic testing (DARHT) facility uses two electron linear-induction accelerators (LIA) to produce the radiographic source spots for perpendicular views of a hydrotest. The first of these LIAs produces a single pulse, with a fixed {approx}60-ns pulsewidth. The second axis LIA produces as many as four pulses within 1.6-{micro}s, with variable pulsewidths and separation. There are a wide variety of hydrotest geometries, each with a unique radiographic requirement, so there is a need to adjust the radiographic dose for the best images. This can be accomplished on the second axis by simply adjusting the pulsewidths, but is more problematic on the first axis. Changing the beam energy or introducing radiation attenuation also changes the spectrum, which is undesirable. Moreover, using radiation attenuation introduces significant blur, increasing the effective spot size. The dose can also be adjusted by changing the beam kinetic energy. This is a very sensitive method, because the dose scales as the {approx}2.8 power of the energy, but it would require retuning the accelerator. This leaves manipulating the beam current as the best means for adjusting the dose, and one way to do this is to change the size of the cathode. This method has been proposed, and is being tested. This article describes simulations undertaken to develop scaling laws for use as design tools in changing the Axis-1 beam current by changing the cathode size.

  9. The manufacturing and metrology of off-axis mirrors

    Penzkofer, Karlheinz; Rascher, Rolf; Küpper, Lutz; Liebl, Johannes


    Especially in the area of the large mirror manufacturing only a few manufacturers are capable to produce optical surfaces of high quality. Therefore a deterministic process should be developed in the project IFasO. In the field of telescope optics off-axis optical systems are becoming increasingly important. These systems try to avoid an obstructing of the incoming light by moving the secondary mirror out of the primary mirror's optical axis. This advantage leads to an increasing market for this type of optical surface. Until now off-axis mirrors were difficult or almost impossible to produce. With the processes developed in IFasO, high quality mirrors become possible. For this reason, this paper describes the manufacturing of off-axis surfaces and its problems. The mirror production used in the project IFasO is based on the specific design of the CNC center developed by the company Optotech. This center UPG2000 is capable of grinding, polishing, sagitta measurement and interferometric measurement in one mounting of the specimen. Usually a large optics has to be transported during their manufacturing after every individual process step. There is always a risk of damage of the specimen. The exact orientation of the surface relatively to the tool position is also required. This takes a huge amount of time and makes up most of the production time. In this presentation the use of UPG2000 and the next steps within the process development are described. In the current status the manufacturing of large off-axis elements with a PV < λ/10 rms is reproducible.

  10. Velocity measurement of model vertical axis wind turbines

    Johnson, D.A.; McWilliam, M. [Waterloo Univ., ON (Canada). Dept. of Mechanical Engineering


    An increasingly popular solution to future energy demand is wind energy. Wind turbine designs can be grouped according to their axis of rotation, either horizontal or vertical. Horizontal axis wind turbines have higher power output in a good wind regime than vertical axis turbines and are used in most commercial class designs. Vertical axis Savonius-based wind turbine designs are still widely used in some applications because of their simplistic design and low wind speed performance. There are many design variables that must be considered in order to optimize the power output in a given wind regime in a typical wind turbine design. Using particle image velocimetry, a study of the air flow around five different model vertical axis wind turbines was conducted in a closed loop wind tunnel. A standard Savonius design with two semi-circular blades overlapping, and two variations of this design, a deep blade and a shallow blade design were among the turbine models included in this study. It also evaluated alternate designs that attempt to increase the performance of the standard design by allowing compound blade curvature. Measurements were collected at a constant phase angle and also at random rotor orientations. It was found that evaluation of the flow patterns and measured velocities revealed consistent and stable flow patterns at any given phase angle. Large scale flow structures are evident in all designs such as vortices shed from blade surfaces. An important performance parameter was considered to be the ability of the flow to remain attached to the forward blade and redirect and reorient the flow to the following blade. 6 refs., 18 figs.

  11. DESIGN NOTE: A low interaction two-axis wind tunnel force balance designed for large off-axis loads

    Ostafichuk, Peter M.; Green, Sheldon I.


    A novel two-axis wind tunnel force balance using air bushings for off-axis load compensation has been developed. The design offers a compact, robust, and versatile option for precisely measuring horizontal force components irrespective of vertical and moment loads. Two independent stages of cylindrical bushings support large moments and vertical force; there is low interaction due to the minimal friction along the horizontal measurement axes. The current design measures drag and side forces up to 70 N and can safely operate in the presence of vertical loads as large as 2200 N and moment loads up to 425, 750, and 425 N m in roll, pitch, and yaw, respectively. Eleven drag axis calibration trials were conducted with a variety of applied vertical forces and pitching moments. The individual linear calibration slopes for the trials agreed to within 0.18% and the largest residual from all calibrations was 0.38% of full scale. As the residuals were found to obey a normal distribution, with 99% certainty the expected drag resolution of the device is better than 0.30% of full scale, independent of off-axis loads.

  12. Tuning the DARHT Axis-II linear induction accelerator focusing

    Ekdahl, Carl A. [Los Alamos National Laboratory


    Flash radiography of large hydrodynamic experiments driven by high explosives is a well-known diagnostic technique in use at many laboratories, and the Dual-Axis Radiography for Hydrodynamic Testing (DARHT) facility at Los Alamos produces flash radiographs of large hydrodynamic experiments. Two linear induction accelerators (LIAs) make the bremsstrahlung radiographic source spots for orthogonal views of each test. The 2-kA, 20-MeV Axis-I LIA creates a single 60-ns radiography pulse. The 1.7-kA, 16.5-MeV Axis-II LIA creates up to four radiography pulses by kicking them out of a longer pulse that has a 1.6-{mu}s flattop. The Axis-II injector, LIA, kicker, and downstream transport (DST) to the bremsstrahlung converter are described. Adjusting the magnetic focusing and steering elements to optimize the electron-beam transport through an LIA is often called 'tuning.' As in all high-current LIAs, the focusing field is designed to be as close to that of the ideal continuous solenoid as physically possible. In ideal continuous solenoidal transport a smoothly varying beam size can easily be found for which radial forces balance, and the beam is said to be 'matched' to the focusing field. A 'mismatched' beam exhibits unwanted oscillations in size, which are a source of free energy that contributes to emittance growth. This is undesirable, because in the absence of beam-target effects, the radiographic spot size is proportional to the emittance. Tuning the Axis-II LIA is done in two steps. First, the solenoidal focusing elements are set to values designed to provide a matched beam with little or no envelope oscillations, and little or no beam-breakup (BBU) instability growth. Then, steering elements are adjusted to minimize the motion of the centroid of a well-centered beam at the LIA exit. This article only describes the design of the tune for the focusing solenoids. The DARHT Axis-II LIA was required to be re-tuned after installing an

  13. Psychiatric Axis I Comorbidities among Patients with Gender Dysphoria

    Azadeh Mazaheri Meybodi


    Full Text Available Objectives. Cooccurring psychiatric disorders influence the outcome and prognosis of gender dysphoria. The aim of this study is to assess psychiatric comorbidities in a group of patients. Methods. Eighty-three patients requesting sex reassignment surgery (SRS were recruited and assessed through the Persian Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I. Results. Fifty-seven (62.7% patients had at least one psychiatric comorbidity. Major depressive disorder (33.7%, specific phobia (20.5%, and adjustment disorder (15.7% were the three most prevalent disorders. Conclusion. Consistent with most earlier researches, the majority of patients with gender dysphoria had psychiatric Axis I comorbidity.

  14. Development of the adrenal axis in the neonatal rat

    Guillet, Ronnie


    Plasma corticosterone and ACTH concentrations were determined in neonatal rats 1, 7, 14, and 21 days old, under a variety of experimental conditions, to obtain more information on the postnatal development of the rat hypothalamo-adrenal (HHA) axis. The results indicate that: (1) there is a diminution followed by an increase in responsiveness of the adrenal gland, but the pituitary response to direct hormonal stimulation is unchanged during the first three postnatal weeks; (2) continued stimulation of the adrenal by ACTH or of the central nervous system (CNS) or hypothalamus by corticosterone is necessary during early postnatal development to allow normal maturation of the HHA axis; and (3) feedback inhibition is operative by birth, at least to a moderate degree. Taken together, the studies suggest that both the adrenal and pituitary glands are potentially functional at birth, but that the hypothalamic and CNS mediators of the stress response are not mature until at least the second or third postnatal week. (ERB)

  15. A new vertical axis wind turbine design for urban areas

    Frunzulica, Florin; Cismilianu, Alexandru; Boros, Alexandru; Dumitrache, Alexandru; Suatean, Bogdan


    In this paper we aim at developing the model of a Vertical Axis Wind Turbine (VAWT) with the short-term goal of physically realising this turbine to operate at a maximmum power of 5 kW. The turbine is designed for household users in the urban or rural areas and remote or isolated residential areas (hardly accsessible). The proposed model has a biplane configuration on each arm of the VAWT (3 × 2 = 6 blades), allowing for increased performance of the turbine at TSR between 2 and 2.5 (urban area operation) compared to the classic vertical axis turbines. Results that validate the proposed configuration as well as passive control methods to increase the performance of the classic VAWTs are presented.

  16. Application of one-axis sun tracking system

    This paper introduces design and application of a novel one-axis sun tracking system which follows the position of the sun and allows investigating effects of one-axis tracking system on the solar energy in Turkey. The tracking system includes a serial communication interface based on RS 485 to monitor whole processes on a computer screen and to plot data as graphic. In addition, system parameters such as the current, the voltage and the panel position have been observed by means of a microcontroller. The energy collected is measured and compared with a fixed solar system for the same solar panel. The results show that the solar energy collected on the tracking system is considerably much efficient than the fixed system. The tracking system developed in this study provides easy installation, simple mechanism and less maintenance.

  17. Design optimization and analysis of vertical axis wind turbine blade

    Wind energy is clean and renwable source of energy and is also the world's fastest growing energy resource. Keeping in view power shortages and growing cost of energy, the low cost wind energy has become a primary solution. It is imperative that economies and individuals begin to conserve energy and focus on the production of energy from renewable sources. Present study describes a wind turbine blade designed with enhanced aerodynamic properties. Vertical axis turbine is chosen because of its easy installment, less noisy and having environmental friendly characteristics. Vertical axis wind turbines are thought to be ideal for installations where wind conditions are not consistent. The presented turbine blade is best suitable for roadsides where the rated speed due to vehicles is most /sup -1/ often 8 ms .To get an optimal shape design symmetrical profile NACA0025 has been considered which is then analyzed for stability and aerodynamic characteristics at optimal conditions using analysis tools ANSYS and CFD tools. (author)

  18. A single-axis testbed for slewing control experiments

    Hamilton, Jonathan; Lee, Gordon K. F.; Juang, Jer-Nan


    A simple single-axis testbed is described, and initial experimental results are presented to illustrate collocated and noncollocated control for this structure. The testbed is made up of a pair of single-axis flexible beams attached to a DC servo motor. An optical encoder and strain gauges provide hub and beam position information, respectively. The system is driven by an IBM PC system; with a motor controller, a programmable digital filter processes position error information through user-selected gains and pole-zero configurations. A 25-kHz data acquisition system provides the necessary interface between processor and motor. The control approaches currently being investigated include collocated PD control and noncollocated phase compensation.

  19. Jet maximization, axis minimization, and stable cone finding

    Thaler, Jesse


    Jet finding is a type of optimization problem, where hadrons from a high-energy collision event are grouped into jets based on a clustering criterion. As three interesting examples, one can form a jet cluster that (i) optimizes the overall jet four-vector, (ii) optimizes the jet axis, or (iii) aligns the jet axis with the jet four-vector. In this paper, we show that these three approaches to jet finding, despite being philosophically quite different, can be regarded as descendants of a mother optimization problem. For the special case of finding a single cone jet of fixed opening angle, the three approaches are genuinely identical when defined appropriately, and the result is a stable cone jet with the largest value of a quantity J . This relationship is only approximate for cone jets in the rapidity-azimuth plane, as used at the Large Hadron Collider, though the differences are mild for small radius jets.

  20. Summary of tower designs for large horizontal axis wind turbines

    Frederick, G. R.; Savino, J. M.


    Towers for large horizontal axis wind turbines, machines with a rotor axis height above 30 meters and rated at more than 500 kW, have varied in configuration, materials of construction, type of construction, height, and stiffness. For example, the U.S. large HAWTs have utilized steel truss type towers and free-standing steel cylindrical towers. In Europe, the trend has been to use only free-standing and guyed cylindrical towers, but both steel and reinforced concrete have been used as materials of construction. These variations in materials of construction and type of construction reflect different engineering approaches to the design of cost effective towers for large HAWTs. Tower designs are the NASA/DOE Mod-5B presently being fabricated. Design goals and requirements that influence tower configuration, height and materials are discussed. In particular, experiences with United States large wind turbine towers are elucidated. Finally, current trends in tower designs for large HAWTs are highlighted.

  1. Effects of structure flexibility on horizontal axis wind turbine performances

    Coiro, D. P.; Daniele, E.; Scherillo, F.


    This work illustrates the effects of flexibility of rotor blades and turbine tower on the performances of an horizontal axis wind turbine (HAWT) designed by our ADAG research group, by means of several example applied on a recent project for a active pitch controlled upwind 60 kW HAWT. The influence of structural flexibility for blade only, tower only and blade coupled with tower configuration is investigated using an aero-elastic computer-aided engineering (CAE) tool for horizontal axis wind turbines named FAST developed at National Renewable Energy Laboratory (NREL) of USA. For unsteady inflow conditions in front of the isolated HAWT the performances in rigid and flexible operation mode are computed and compared in order to illustrate the limitation included within a classical rigid body approach to wind turbine simulation.

  2. Early programming of the IGF-I axis

    Larnkjær, Anni; Ingstrup, Helga Kristensen; Schack-Nielsen, Lene;


    -I production. Conversely, studies suggest that later in childhood, those breastfed are taller and have higher IGF-I levels. Therefore, it has been suggested that the IGF-I axis may be programmed by diet during infancy. The association between IGF-I in infancy and later life is not known. OBJECTIVE: To examine...... for gender, breastfeeding, and other covariates. Likelihood ratio test based on residual log likelihood was applied for analysis including all measurements during infancy. RESULTS: There was an inverse association between IGF-I at 9 months and 17 years (r=-0.39, P=0.014, and n=40). A 1 ng/ml higher IGF......=-0.26, P=0.043, and n=109). CONCLUSION: The results support the hypothesis that the IGF-I axis can be programmed early in life....

  3. Off-axis Fresnel numbers in laser systems

    Yudong; Yao; Junyong; Zhang; Yanli; Zhang; Qunyu; Bi; Jianqiang; Zhu


    The physical meaning and essence of Fresnel numbers are discussed,and two definitions of these numbers for offaxis optical systems are proposed.The universal Fresnel number is found to be N =(a2/λz) * C1+ C2.The Rayleigh–Sommerfeld nonparaxial diffraction formula states that a simple analytical formula for the nonparaxial intensity distribution after a circular aperture can be obtained.Theoretical derivations and numerical calculations reveal that the first correction factor C1 is equal to cos θ and the second factor C2 is a function of the incident wavefront and the shape of the diffractive aperture.Finally,some diffraction phenomena in off-axis optical systems are explained by the off-axis Fresnel number.

  4. Electrostatic levitation under the single-axis feedback control condition


    An electrostatic levitator with a single-axis feedback control system was developed on the basis of electric field analysis and optimum design for levitation electrodes. In order to realize the stable levitation of various types of materials such as metals, inorganic materials and polymers, we made both experimental and theoretical investigations to solve the four key problems of electric field optimization, sample position detecting, sample charging control and levitation voltage minimization. Under the capacitive induction charging condition, a sample with the size of 2.6–4.5 mm usually bears positive charges amounting to 10-9 Coulomb. Because the single-axis feedback control system responds quickly, it takes the levitated sample only 0.1 s from leaving the bottom electrode until attaining a stable levitation in the upright direction. The levitated sample displays satisfactory levitation stability in both the upright and the horizontal directions owing to the constraining force produced by spherical electrodes.

  5. Psychiatric Axis I Comorbidities among Patients with Gender Dysphoria

    Hajebi, Ahmad


    Objectives. Cooccurring psychiatric disorders influence the outcome and prognosis of gender dysphoria. The aim of this study is to assess psychiatric comorbidities in a group of patients. Methods. Eighty-three patients requesting sex reassignment surgery (SRS) were recruited and assessed through the Persian Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I). Results. Fifty-seven (62.7%) patients had at least one psychiatric comorbidity. Major depressive disorder (33.7%), specific phobia (20.5%), and adjustment disorder (15.7%) were the three most prevalent disorders. Conclusion. Consistent with most earlier researches, the majority of patients with gender dysphoria had psychiatric Axis I comorbidity. PMID:25180172

  6. The Wake of a Single Vertical Axis Wind Turbine

    Barsky, Danielle

    Vertical axis wind turbines (VAWTs) pose various advantages over traditional horizontal axis wind turbines (HAWTs), including their smaller size and footprint, quiet operation, and ability to produce power under a greater variety of wind directions and wind speeds. To determine the optimal spacing of an array of VAWTs for maximum power output, an understanding of the fundamental wake structure of a single VAWT is needed. This study is among the first attempts to experimentally visualize the wake of a VAWT using stereo particle image velocimetry (PIV). A scale VAWT is placed inside a wind tunnel and a motor rotates the scale model at a constant rotational speed. Wake data at several Reynolds numbers and tip speed ratios indicate that vortices are shed by each blade of the spinning VAWT, demonstrating significant differences between the wake of a VAWT and a spinning cylinder.

  7. Flow-blade interaction in a Vertical Axis Wind Turbine

    Dominguez, Roberto; Piedra, Saul; Ramos, Eduardo


    We present an analysis of the interaction between an incoming wind and three airfoils symmetrically located, and free to rotate around a common axis. The geometrical configuration considered is a two dimensional model of Vertical Axis Wind Turbine. The model is based in the conservation equations of the fluid coupled with the Newton-Lagrange equations for the interaction with the airfoils. The presence of the rigid body in the fluid is simulated using immersed boundary conditions. The interaction of the wind with the airfoil located further upstream generates a force on the airfoil and vortices that are swept downstream and collide with the other airfoils. This effect generates a complex interplay of dynamical forces whose resultant is a torque that sets the system in motion. We describe the flow around the airfoils and examine the efficiency of the system as a function of geometric variables. Our conclusions are potentially useful for the design of VAWT's.

  8. The axis of orientation of the synlophe in the Heligmosomoidea (Nematoda, Trichostrongylina: a new approach

    Durette-Desset M.C.


    Full Text Available The definition of the axis of orientation of the synlophe is modified for the Heligmosomoidea so that one or two axes may be recognized. When two axes are present, their inclinations to the sagittal axis are different on the right and left sides, and we propose to name them right axis and left axis, respectively. During the course of evolution, starting from a single oblique axis (plesiomorphic state, an independent rotation of this axis on the right and left sides may bring about a double-axis state with a different inclination on both sides (derived state. When the rotation reaches 90° for both sides, the axis becomes simple once again and is superimposed to the frontal axis (most derived state.

  9. Kinematical smoothing of rotary axis near singularity point

    Grandguillaume, Laureen; Lavernhe, Sylvain; Tournier, Christophe


    This paper deals with singular configurations of a 5-axis machine tool in high speed milling which may lead to the appearance of large incoherent movements of rotary axes near singularity points. These movements generate slowdowns of the actual feedrate during the execution of the tool path, which affect quality and productivity. Thus, this paper proposes a method to detect these behaviors during machining simulation and correct the tool path. Unlike the literature methods, this correction co...

  10. Social Deprivation and the HPA Axis in Early Development

    Koss, Kalsea J; Hostinar, Camelia E.; Donzella, Bonny; Gunnar, Megan R.


    Growing evidence suggests that early social deprivation impacts the activity of the hypothalamic-pituitary-adrenocortical axis. Early adverse care in the form of institutional or orphanage care provides a human model for early social deprivation. The present study examined changes in diurnal cortisol during the transition to family care in the first two years post-adoption. Children adopted between 15 and 36 months from institutional care were examined four times during thei...

  11. Dynamic behavior analysis for a six axis industrial machining robot

    Bisu, Claudiu-Florinel; Cherif, Medhi; Gérard, Alain; K'Nevez, Jean-Yves


    The six axis robots are widely used in automotive industry for their good repeatability (as defined in the ISO92983) (painting, welding, mastic deposition, handling etc.). In the aerospace industry, robot starts to be used for complex applications such as drilling, riveting, fiber placement, NDT, etc. Given the positioning performance of serial robots, precision applications require usually external measurement device with complexes calibration procedure in order to reach the precision needed...

  12. Development of Rotary Axis for Wire Electrical Discharge Machining (WEDM)

    M. Parthiban, C. Manigandan, G. Muthu Venkadesh, M. Ranjith Kumar


    This paper gives an overview of setting up a rotary axis to the existing WEDM machine to investigate the machining parameters in WEDG of harder materials. There are a number of hybrid machining processes (HMPs) seeking the combined advantage of EDM and other machining techniques. One such combination is wire electrical discharge grinding (WEDG), which is commonly used for micro-machining of fine and hard rods. WEDG employs a single wire guide to confine the wir...

  13. Vessel Axis Tracking Using Topology Constrained Surface Evolution

    Manniesing, Rashindra; Viergever, M A; Niessen, Wiro


    textabstractAn approach to three-dimensional vessel axis tracking based on surface evolution is presented. The main idea is to guide the evolution of the surface by analyzing its skeleton topology during evolution, and imposing shape constraints on the topology. For example, the intermediate topology can be processed such that it represents a single vessel segment, a bifurcation, or a more complex vascular topology. The evolving surface is then re-initialized with the newly found topology. Re...

  14. Targeting the gut-liver axis in cirrhosis

    Madsen, Bjørn S; Havelund, Troels; Krag, Aleksander


    The gut-liver axis in cirrhosis and portal hypertension is gaining increasing attention as a key pathophysiological mechanism responsible for progression of liver failure and development of complications such as spontaneous infections and hepatocellular carcinoma. Antibiotics and non-selective β...... the issue of pharmacological treatment of cirrhosis and portal hypertension with antibiotics and NSBB. We discuss their mechanism of action and suggest that combining the two treatment modalities could potentially reduce the risk of complications....

  15. Resonance Shift of Single-Axis Acoustic Levitation

    XIE Wen-Jun; WEI Bing-Bo


    @@ The resonance shift due to the presence and movement of a rigid spherical sample in a single-axis acoustic levitator is studied with the boundary element method on the basis of a two-cylinder model of the levitator.The introduction of a sample into the sound pressure nodes, where it is usually levitated, reduces the resonant interval Hn (n is the mode number) between the reflector and emitter.

  16. Dual-axis MEMS force sensors for gecko adhesion studies

    Hill, Ginel Corina

    Dual-axis piezoresistive microelectromechanical systems (MEMS) force sensors were used to investigate the effects of orientation angle on the adhesion of gecko hairs, called setae. These hairs are part of a fantastic, robust dry adhesive. Their adhesion is highly angle-dependent, with both the "pitch" and "roll" orientation angles playing a role. This anisotropy in adhesion properties is critical for locomotion, as it enables detachment of the gecko's foot with limited pull-off force. Many synthetic mimics of the gecko adhesive are isotropic. This work on the anisotropy of natural setae will inform future work on synthetic dry adhesives. A dual-axis microscale force sensor was needed to study single seta adhesive forces, which are stronger parallel to a substrate than perpendicular. Piezoresistive silicon cantilevers that separately detect lateral and normal forces applied at the tip were used. The fabrication process and rigorous characterization of new devices are reported. A novel calibration method was developed that uses resonant frequency measurements in concert with finite element models to correct for the expected variability of critical dimensions. These corrected models were used to predict the stiffnesses of each cantilever, and thus improve the accuracy of force measurements made with these sensors. This calibration technique was also validated by direct measurement of the dual-axis cantilever stiffnesses using a reference cantilever. The adhesion force of a single gecko seta is dramatically enhanced by proper orientation. The dual-axis cantilevers were used to measure two components of force between a substrate and a Gekko gecko seta. Lateral adhesion was highest with the stalk oriented parallel to the surface at 0° pitch. Adhesion decreased smoothly as the pitch angle of the stalk was increased, until detachment or no adhesion occurred at approximately 30°. To display enhanced adhesion, the splayed tuft at the end of the seta needed to be only

  17. Psychiatric Axis I Comorbidities among Patients with Gender Dysphoria

    Azadeh Mazaheri Meybodi; Ahmad Hajebi; Atefeh Ghanbari Jolfaei


    Objectives. Cooccurring psychiatric disorders influence the outcome and prognosis of gender dysphoria. The aim of this study is to assess psychiatric comorbidities in a group of patients. Methods. Eighty-three patients requesting sex reassignment surgery (SRS) were recruited and assessed through the Persian Structured Clinical Interview for DSM-IV Axis I disorders (SCID-I). Results. Fifty-seven (62.7%) patients had at least one psychiatric comorbidity. Major depressive disorder (33.7%), speci...

  18. 6-Axis Force/Moment Sensor In Humanoid Robot Foot

    Ai-Faifi, Badrih; Al-Shammary, Maryam; Al-Shehry, Zinab


    The foot is the most Important part of the humanoid .Thought the sensor of the robot can understand the environment In which they live, it is important to developed an intelligent foot. In order to walk on uneven terrain safely this poster describes an intelligent foot with 6- axis force/moment sensors for humanoid robot that is one of the solution that can help the robot to walk in uneven terrain safely.

  19. Bendability optimization of flexible optical nanoelectronics via neutral axis engineering

    Lee, Sangmin; Kwon, Jang-Yeon; Yoon, Daesung; Cho, Handong; You, Jinho; Kang, Yong Tae; Choi, Dukhyun; Hwang, Woonbong


    The enhancement of bendability of flexible nanoelectronics is critically important to realize future portable and wearable nanoelectronics for personal and military purposes. Because there is an enormous variety of materials and structures that are used for flexible nanoelectronic devices, a governing design rule for optimizing the bendability of these nanodevices is required. In this article, we suggest a design rule to optimize the bendability of flexible nanoelectronics through neutral axi...

  20. Inversion of the chordate body axis: are there alternatives?

    Gerhart, J.


    One major morphological difference between chordates and annelids or arthropods is the opposite orientation of the nerve cord and heart. A long-standing proposal is that the chordate axis evolved by inverting the body of an ancestor with the annelid/arthropod orientation. However, the data can also be explained by a common ancestor with diffuse dorsoventral organization, followed by oppositely directed condensation of the nerve cord and relocation of the heart in the two lines.

  1. Inversion of the chordate body axis: Are there alternatives?

    Gerhart, J.


    One major morphological difference between chordates and annelids or arthropods is the opposite orientation of the nerve cord and heart. A long-standing proposal is that the chordate axis evolved by inverting the body of an ancestor with the annelid/arthropod orientation. However, the data can also be explained by a common ancestor with diffuse dorsoventral organization, followed by oppositely directed condensation of the nerve cord and relocation of the heart in the t...

  2. Neuropeptides and the Microbiota-Gut-Brain Axis

    Holzer, Peter; Farzi, Aitak


    Neuropeptides are important mediators both within the nervous system and between neurons and other cell types. Neuropeptides such as substance P, calcitonin gene-related peptide and neuropeptide Y (NPY), vasoactive intestinal polypeptide, somatostatin and corticotropin-releasing factor are also likely to play a role in the bidirectional gut-brain communication. In this capacity they may influence the activity of the gastrointestinal microbiota and its interaction with the gut-brain axis. Curr...

  3. The Parameters Affect on Power Coefficient Vertical Axis Wind Turbine


    ABSTRACT: This study describes the design of a special type of vertical axis rotor wind turbine with moveable vertically positioned vanes. The novel design increases the torque in the left side of the wind turbine by increasing the drag coefficient. It also reduces the negative torque of the frame which rotates contrary to the wind in the other side. Two different types of models, having different vane shapes (flat vane and cavity shaped vane), were fabricated. Each type consisted of two mode...

  4. The method of isolines for the shower axis determination

    Kirov, I. N.; Stamenov, J. N.


    The method of isolines (contours) is proposed to be used for deter- mination of core location of extensive air shower on the array plane. As variable z=f(x,y) are used flux densities of particles, registrated from ground detectors. Obtained isolines are approximated with circles, which centers show impact point of shower axis. The method was demostrated on experimental data from Tien-Shan shower array in period 1974-82. The possibilities and difficulties of the method are discussed.

  5. CFD Simulation of Twin Vertical Axis Tidal Turbines System

    Syed Shah Khalid; Zhang Liang; Sheng Qi-hu


    As concerns about rising fossil-fuel prices, energy security and climate-change increase, renewable energy can play a vital role in producing local, clean and inexhaustible energy to supply world rising demand for electricity. In this study, hydrodynamic analysis of vertical axis tidal turbine operating side-by-side is numerically analyzed. Two-dimensional numerical modeling of the unsteady flow through the blades of the turbine is performed using ANSYS CFX, hereafter CFX; this is based on a ...

  6. Multi axis differential optical absorption spectroscopy (MAX-DOAS)

    Hönninger, G.; Von Friedeburg, C.; U. Platt


    Multi Axis Differential Optical Absorption Spectroscopy (MAX-DOAS) in the atmosphere is a novel measurement technique that represents a significant advance on the well-established zenith scattered sunlight DOAS instruments which are mainly sensitive to stratospheric absorbers. MAX-DOAS utilizes scattered sunlight received from multiple viewing directions. The spatial distribution of various trace gases close to the instrument can be derived by combining several viewing directions. Ground...

  7. Multi axis differential optical absorption spectroscopy (MAX-DOAS)

    Hönninger, G.; Friedeburg, C.; U. Platt


    Multi Axis Differential Optical Absorption Spectroscopy (MAX-DOAS) in the atmosphere is a novel measurement technique that represents a significant advance on the well-established zenith scattered sunlight DOAS instruments which are mainly sensitive to stratospheric absorbers. MAX-DOAS utilizes scattered sunlight received from multiple viewing directions. The spatial distribution of various trace gases close to the instrument can be derived by combining sev...

  8. Estimation of power in low velocity vertical axis wind turbine

    Sampath, S. S.; Shetty, Sawan; Chithirai Pon Selvan, M.


    The present work involves in the construction of a vertical axis wind turbine and the determination of power. Various different types of turbine blades are considered and the optimum blade is selected. Mechanical components of the entire setup are built to obtain maximum rotation per minute. The mechanical energy is converted into the electrical energy by coupling coaxially between the shaft and the generator. This setup produces sufficient power for consumption of household purposes which is economic and easily available.

  9. The reno-pineal axis: A novel role for melatonin

    Sanjay Kalra; Swati Agrawal; Manisha Sahay


    The pineal gland is a tiny endocrine gland whose physiologic role has been the focus of much research and much more speculation over the past century. This mini-review discusses recent findings which correlate melatonin and renal physiology, and postulates the presence of a “reno-pineal axis.” Drawing lessons from comparative endocrinology, while quoting human data, it advocates the need to study the “reno-pineal axis” in greater detail.

  10. Maternal control of the Drosophila dorsal–ventral body axis

    Stein, David S.; Stevens, Leslie M.


    The pathway that generates the dorsal–ventral (DV) axis of the Drosophila embryo has been the subject of intense investigation over the previous three decades. The initial asymmetric signal originates during oogenesis by the movement of the oocyte nucleus to an anterior corner of the oocyte, which establishes DV polarity within the follicle through signaling between Gurken, the Drosophila Transforming Growth Factor (TGF)-α homologue secreted from the oocyte, and the Drosophila Epidermal Growt...

  11. Design, Operation and Diagnostics of a Vertical Axis Wind Turbine

    Colley, Gareth


    The need for sustainable energy sources becomes greater each year due to the continued depletion of fossil fuels and the resulting energy crisis. Solutions to this problem are potentially in the form of wind turbines which have been receiving increased support at a micro level. At present a number of wind turbines are being developed that are of cross-flow vertical axis operation which have shown significant increases in performance compared to existing technologies. From an extensive literat...

  12. Towards the Evolution of Novel Vertical-Axis Wind Turbines

    Preen, Richard J.; Bull, Larry


    Renewable and sustainable energy is one of the most important challenges currently facing mankind. Wind has made an increasing contribution to the world's energy supply mix, but still remains a long way from reaching its full potential. In this paper, we investigate the use of artificial evolution to design vertical-axis wind turbine prototypes that are physically instantiated and evaluated under approximated wind tunnel conditions. An artificial neural network is used as a surrogate model to...

  13. Study of axis-symmetry for judgement on nuclear parts

    In this paper, gamma-ray distributions from nuclear weapon parts of different shapes are simulated. The gamma-rays from a cylinder nuclear part have axis-symmetry distribution, while the gamma-rays from prism nuclear parts are of asymmetry distribution. The quadra- and penta-prism distributions differ obviously from that of the cylinder. However, the asymmetry of hexa-, octo- and dodeca-prism reduces gradually to approach to the symmetry distribution of the cylinder. (authors)

  14. Orthogonal Analysis Based Performance Optimization for Vertical Axis Wind Turbine

    Lei Song; Hong-Zhao Liu; Zong-Xiao Yang


    Geometrical shape of a vertical axis wind turbine (VAWT) is composed of multiple structural parameters. Since there are interactions among the structural parameters, traditional research approaches, which usually focus on one parameter at a time, cannot obtain performance of the wind turbine accurately. In order to exploit overall effect of a novel VAWT, we firstly use a single parameter optimization method to obtain optimal values of the structural parameters, respectively, by Computational ...

  15. Aerodynamic Analysis Models for Vertical-Axis Wind Turbines

    Brahimi, M. T.; A. Allet; I. Paraschivoiu


    This work details the progress made in the development of aerodynamic models for studying Vertical-Axis Wind Turbines (VAWT's) with particular emphasis on the prediction of aerodynamic loads and rotor performance as well as dynamic stall simulations. The paper describes current effort and some important findings using streamtube models, 3-D viscous model, stochastic wind model and numerical simulation of the flow around the turbine blades. Comparison of the analytical results with available e...

  16. Vertical axis wind turbine in a falling soap film

    Araya, Daniel B.; Dabiri, John O.


    Vertical axis wind turbines (VAWTs) have demonstrated a potential to significantly enhance the efficiency of energy harvesting within a wind farm. One mechanism that contributes to this enhancement is a VAWT’s inherent insensitivity to wind direction coupled with blockage within an array of turbines. Much like the flow around a bluff body, turbine blockage can locally accelerate the flow near one turbine, providing faster inflow conditions for a well-placed neighboring turbine. Since the powe...

  17. Reliability of floating foundation concepts for vertical axis wind turbines

    Athanasios J. Kolios; Collu, Maurizio; Brennan, Feargal P.


    Offshore wind turbines are developing at a rapid pace. By far the most common turbine configuration is the HAWT (Horizontal Axis Wind Turbine) and development of these machines is largely centered about drive train and blade issues with some work concerning foundations/ supporting structures. Several teams around the world are developing floating supporting structures for HAWT, mainly for deep water deployment. This paper describes the development of a floating support structure for Vertical ...

  18. MARRT: Medial Axis biased rapidly-exploring random trees

    Denny, Jory


    © 2014 IEEE. Motion planning is a difficult and widely studied problem in robotics. Current research aims not only to find feasible paths, but to ensure paths have certain properties, e.g., shortest or safest paths. This is difficult for current state-of-the-art sampling-based techniques as they typically focus on simply finding any path. Despite this difficulty, sampling-based techniques have shown great success in planning for a wide range of applications. Among such planners, Rapidly-Exploring Random Trees (RRTs) search the planning space by biasing exploration toward unexplored regions. This paper introduces a novel RRT variant, Medial Axis RRT (MARRT), which biases tree exploration to the medial axis of free space by pushing all configurations from expansion steps towards the medial axis. We prove that this biasing increases the tree\\'s clearance from obstacles. Improving obstacle clearance is useful where path safety is important, e.g., path planning for robots performing tasks in close proximity to the elderly. Finally, we experimentally analyze MARRT, emphasizing its ability to effectively map difficult passages while increasing obstacle clearance, and compare it to contemporary RRT techniques.

  19. Vasoactive intestinal peptide signaling axis in human leukemia

    Glenn; Paul; Dorsam; Keith; Benton; Jarrett; Failing; Sandeep; Batra


    The vasoactive intestinal peptide (VIP) signaling axis constitutes a master "communication coordinator" between cells of the nervous and immune systems.To date,VIP and its two main receptors expressed in T lymphocytes,vasoactive intestinal peptide receptor (VPAC)1 and VPAC2,mediate critical cellular functions regulating adaptive immunity,including arresting CD4 T cells in G 1 of the cell cycle,protection from apoptosis and a potent chemotactic recruiter of T cells to the mucosa associated lymphoid compartment of the gastrointestinal tissues.Since the discovery of VIP in 1970,followed by the cloning of VPAC1 and VPAC2 in the early 1990s,this signaling axis has been associated with common human cancers,including leukemia.This review highlights the present day knowledge of the VIP ligand and its receptor expression profile in T cell leukemia and cell lines.Also,there will be a discussion describing how the anti-leukemic DNA binding transcription factor,Ikaros,regulates VIP receptor expression in primary human CD4 T lymphocytes and T cell lymphoblastic cell lines (e.g.Hut-78).Lastly,future goals will be mentioned that are expected to uncover the role of how the VIP signaling axis contributes to human leukemogenesis,and to establish whether the VIP receptor signature expressed by leukemic blasts can provide therapeutic and/or diagnostic information.

  20. CMB Maximum Temperature Asymmetry Axis: Alignment with Other Cosmic Asymmetries

    Mariano, Antonio


    We use a global pixel based estimator to identify the axis of the residual Maximum Temperature Asymmetry (MTA) (after the dipole subtraction) of the WMAP 7 year Internal Linear Combination (ILC) CMB temperature sky map. The estimator is based on considering the temperature differences between opposite pixels in the sky at various angular resolutions (4 degrees-15 degrees and selecting the axis that maximizes this difference. We consider three large scale Healpix resolutions (N_{side}=16 (3.7 degrees), N_{side}=8 (7.3 degrees) and N_{side}=4 (14.7 degrees)). We compare the direction and magnitude of this asymmetry with three other cosmic asymmetry axes (\\alpha dipole, Dark Energy Dipole and Dark Flow) and find that the four asymmetry axes are abnormally close to each other. We compare the observed MTA axis with the corresponding MTA axes of 10^4 Gaussian isotropic simulated ILC maps (based on LCDM). The fraction of simulated ILC maps that reproduces the observed magnitude of the MTA asymmetry and alignment wit...

  1. Calibration of rotary joints in multi-axis machine tools

    Khan, Abdul Wahid; Liu, Fei; Chen, Wuyi


    A novel technique is developed and implemented for error quantification in a rotary joint of a multi-axis machine tool by using a calibrated double ball bar (DBB) system as a working standard. This technique greatly simplified the measurement setup requirement and accelerated the calibration of rotary joints. In addition it is highly economical by reducing the complex optics and eliminating the usage of various tooling, instrumentation and accessories. This methodology is capable of measuring the five degree of freedom (DOF) errors out of 6DOF of a rotary joint by using the calibrated DBB system and a point locating fixture. The methodology is implemented on rotary joints of a five axis CNC machine tools. Equation solvers and error modeling technique are implemented and validity of the methodology and authenticity of the results obtained are tested through simulation in UG and Matlab software. The methodology is found extremely feasible pragmatic, quite simple, efficient and easy to use for error characterization of rotary joints of multi axis machine tools.

  2. A Dual-Axis Electrostatically Driven MEMS Microgripper

    Yukun Jia


    Full Text Available This paper presents the design of a new monolithic two- axis electrostatically actuated MEMS microgripper with integrated capacitive position and force sensors working at the micro-scale level. Each of the two jaws of the micro‐ gripper possesses two degrees-of-freedom (DOF and is capable of positioning in both x-and y-axes. Unlike existing works, where one gripper arm is actuated and other one is sensed, both arms of the proposed microgripper are actuated and sensed independently. A sensing scheme is constructed to provide the position and force signals in the noncontact and contact phases, respectively. By applying a 120V driving voltage, the jaw can provide 70 μm x-axis and 18 μm y-axis displacements with the force of 190 μN. By this design, the real-time position and grasping force information can be obtained in the dual sensing mode. Both analytical calculation and finite-element analysis (FEA were performed to verify the performance of the proposed design. A scaled-up prototype is designed, fabricated and tested through the experiment to verify the structure design of the microgripper.

  3. l=1 helical axis heliotron device in Kyoto university

    Helical systems are an attractive candidate for magnetic fusion reactor. Recently, there has been great progress in theoretical research of three dimensional magnetic field structures, resulting in several kinds of confinement optimization being proposed for toroidal magnetic confinement system. For example, some sophisticated ideas have appeared on stage such as quasi-helical symmetry and quasi-isodynamic system. To find experimentally which way is the best Optimisation, a new helical axis heliotron device, so called 'Heliotron J', is under construction in the Institute of Advanced Energy, Kyoto University, Japan. In this conference, the basic concept and the present status will be presented. In the conventional plane axis helical system, it was difficult to have both good particle confinement and good MHD stability simultaneously. The goal of Heliotron J project is to clarify their compatibility in the spatial axis toroidal device. The best way for Optimising the helical magnetic field configuration will be explored by investigating the plasma response to the change in the field components. The main subjects for plasma experiment are: demonstration of the existence of good magnetic flux surfaces, reduction of neoclassical transport in collisionless regime, MHD Stabilisation in high β plasma, controllability of bootstrap current, good confinement of high energy particles

  4. Finding the Orientation of the Stellar Spin Axis

    Wilkinson, Tessa D.; Lesage, Anna-Lea


    The stellar position angle is defined as the projection of the stellar spin axis on the night sky, as measured from North to East. Measuring the stellar position angle gives information that can be used for stellar spin axis evolution and binary formation theories. Current methods to find this angle use imaging with long baseline interferometry for fast rotating stars. There is a lack of observational techniques to find the orientation of the stellar rotation axis for slow rotating stars, which make up the vast majority of stellar population. We developed a new method for determining the absolute stellar position angle for slow rotating stars using a spectro-astrometric analysis of high resolution long-slit spectra. We used the 2m Thueringer Landessternwarte (TLS) telescope to obtain high resolution spectra (R=60,000) with multiple slit orientations to test this method. The stellar rotation causes a tilt in the stellar lines, and the angle of this tilt depends on the stellar position angle and the orientation of the slit. We used a cross-correlation method to compare the subpixel displacements of the position of the photocenter at each slit orientation with telluric lines to obtain the tilt amplitude. We report the results of finding the position angle of the slow rotating K giant Aldebaran and fast rotating reference stars like Vega.

  5. Moving Object Detection Using Graph’s Axis Change Method

    Gagandeep Kaur


    Full Text Available The detection and identify moving objects in a video sequence is very important concept. The currently available techniques for motion estimation can be broadly categorized into main classes: block matching methods and optical flow methods. But here detection of moving objects is detected by using Graph’s axis change method. Here we convert the image in to pixels and then calculate the values when the pixel change its position according to x axis and y axis. There is no problem of fixed and movable background. This paper investigates the different motion estimation algorithms used for video processing applications. Among the available motion estimation methods, the Lucas kanade Algorithm using changed axis’s method has been used in this paper for detection of moving objects in a video sequence. The algorithm produces the result of Horizontal and Vertical components velocity, u and v respectively. This velocity is measured in the form of vectors and has been used to segment the moving objects from the video sequence. The algorithm has been applied to different sets of synthetic and real video sequence.

  6. A sensitive method of determining optic axis azimuth based on laser feedback

    A sensitive method to determine the optic axis azimuth of the birefringence element is presented, which is based on laser feedback. The phase difference between the two intensities in birefringence feedback changes with the angle between the optic axis of the birefringence element and laser original polarization. The phase difference is highly sensitive to the relative position of the optic axis and the laser original polarization. This method is used to highly precisely determine the optic axis azimuth, and is able to distinguish between the fast axis and the slow axis of the birefringence element. Theoretical analysis and experimental results are both demonstrated. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  7. Variation cutting speed on the five axis milling

    S. Torbaty


    Full Text Available Purpose: The aim of this research is to make a study of the effective cutting speed variation in milling with a ball end tool is studied. Then an experimental study of the effect of finishing strategies on surface texture, roughness is described. The material of a specific HB 300 pre-hardened mould steel Super Plast (SP 300.Design/methodology/approach: The methodology has consisted to dertemine cutting speed of each mode of tilt tool in five axes machining, and of proving a series of configurations and parameters combinations: cutting speed Vc, feed rate Vf, and tilt tool in multi-axis milling.Findings: This paper has investigated the effect of the tool orientation on the variation effective cutting speed, on the surface texture, while multi-axis milling. Experimental results have shown that disadvantages of three axes machining results from the existence of very low cutting speeds, even null when the tool axis is normal to the machined surface. This mode of machining generates a bad surface quality. Surfaces have a poor topography and important anisotropy. A suitable slope of the cutting tool by the means of the fifth machine tool axis, improves considerably work piece machined surface quality; Good micro-geometrical surface topography and lower surface roughness.Research limitations/implications: A possible future work would be the development of a general the phenomenal of the residual stress of the cutting on the five axis machining. The behavior is of the residual stress studies are planed in the future. Practical implications: The relationship found between the effective cutting speed and surface texture work piece has an important practical implication since it allows selecting the best cutting condition combination from the points of view both the security and the economy for the established requirements in each case. Results are of great importance in for aerospace and automotive industry.Originality/value: The paper is original since

  8. Drop Axis Ratio Distributions in Stratiform and Convective Rain

    Thurai, M.; Bringi, V. N.; Petersen, W. A.; Schultz, C.


    A fully calibrated low profile 2D video disdrometer (2DVD) has been recording many different rainfall events in Northern Alabama (USA) since June 2007. An earlier publication reported drop shapes and axis ratio distributions determined for some of the events. For one of the cases examined, a noticeable shift in the 3.5 - 3.75 mm drop axis ratio distribution was noted. In this paper, we extend the earlier work by separating the 2DVD measurements into stratiform and convective rain. The separation is made possible by using the minute-by-minute drop size distribution (DSD) measured by the 2DVD. The 1-minute DSDs are fitted to a gamma distribution, and using a simple indexing technique which involves two of the fitted parameters, periods of convective and stratiform rain are separated for a given event. The output of the DSD indexing technique is qualitatively confirmed by comparing with simultaneous time series observations from a co-located UHF profiler which continuously records height profiles of reflectivity, Doppler mean and spectral width, all of which enable the identification of bright-band periods and, furthermore, periods of moderate and deep convection. Excellent consistency is found between the output of the DSD-based separation method and the profiler observations. Next, we utilize the output of DSD index-based separation method to flag the periods of severe convection for a given event. Drop axis ratios during the flagged periods are derived and compared with those during stratiform rain periods. Five cases have been considered. Axis ratio distributions do not show appreciable differences between stratiform and convective periods for four of the cases. The fifth case (the same case as reported earlier) shows a shift in the 3.5 - 3.75 mm drop axis ratios during a prolonged period of convection. The contoured shapes for these drops determined from the 2DVD camera data indicate the possibility of non-axisymmetric oscillations, compared with the contoured


    Zanarini, Mary C.; Barison, Leah K.; Frankenburg, Frances R.; Reich, D. Bradford; Hudson, James I


    The purpose of this study was to assess the familial coaggregation of borderline personality disorder (BPD) with a full array of axis I disorders and four axis II disorders (antisocial personality disorder, histrionic personality disorder, narcissistic personality disorder, and sadistic personality disorder) in the first-degree relatives of borderline probands and axis II comparison subjects. Four hundred and forty-five inpatients were interviewed about familial psychopathology using the Revi...

  10. Automated segmentation of the human hippocampus along its longitudinal axis.

    Lerma-Usabiaga, Garikoitz; Iglesias, Juan Eugenio; Insausti, Ricardo; Greve, Douglas N; Paz-Alonso, Pedro M


    The human hippocampal formation is a crucial brain structure for memory and cognitive function that is closely related to other subcortical and cortical brain regions. Recent neuroimaging studies have revealed differences along the hippocampal longitudinal axis in terms of structure, connectivity, and function, stressing the importance of improving the reliability of the available segmentation methods that are typically used to divide the hippocampus into its anterior and posterior parts. However, current segmentation conventions present two main sources of variability related to manual operations intended to correct in-scanner head position across subjects and the selection of dividing planes along the longitudinal axis. Here, our aim was twofold: (1) to characterize inter- and intra-rater variability associated with these manual operations and compare manual (landmark based) and automatic (percentage based) hippocampal anterior-posterior segmentation procedures; and (2) to propose and test automated rotation methods based on approximating the hippocampal longitudinal axis to a straight line (estimated with principal component analysis, PCA) or a quadratic Bézier curve (fitted with numerical methods); as well as an automated anterior-posterior hippocampal segmentation procedure based on the percentage-based method. Our results reveal that automated rotation and segmentation procedures, used in combination or independently, minimize inconsistencies generated by the accumulation of manual operations while providing higher statistical power to detect well-known effects. A Matlab-based implementation of these procedures is made publicly available to the research community. Hum Brain Mapp 37:3353-3367, 2016. © 2016 Wiley Periodicals, Inc. PMID:27159325

  11. Gaussian tunneling model of c-axis twist Josephson junctions

    We calculate the critical current density JcJ((varphi)0) for Josephson tunneling between identical high-temperature superconductors twisted an angle (varphi)0 about the c axis. Regardless of the shape of the two-dimensional Fermi surface and for very general tunneling matrix elements, an order parameter (OP) with general d-wave symmetry leads to JcJ(π/4)=0. This general result is inconsistent with the data of Li et al. [Phys. Rev. Lett. 83, 4160 (1999)] on Bi2Sr2CaCu2O8+δ (Bi2212), which showed JcJ to be independent of (varphi)0. If the momentum parallel to the barrier is conserved in the tunneling process, JcJ should vary substantially with the twist angle (varphi)0 when the tight-binding Fermi surface appropriate for Bi2212 is taken into account, even if the OP is completely isotropic. We quantify the degree of momentum nonconservation necessary to render JcJ((varphi)0) constant within experimental error for a variety of pair states by interpolating between the coherent and incoherent limits using five specific models to describe the momentum dependence of the tunneling matrix element squared. From the data of Li et al., we conclude that the c-axis tunneling in Bi2212 must be very nearly incoherent, and that the OP must have a nonvanishing Fermi-surface average for Tc. We further show that the apparent conventional sum-rule violation observed by Basov et al. [Science 283, 49 (1999)] can be consistent with such strongly incoherent c-axis tunneling.

  12. Optical diffraction tomography: accuracy of an off-axis reconstruction

    Kostencka, Julianna; Kozacki, Tomasz


    Optical diffraction tomography is an increasingly popular method that allows for reconstruction of three-dimensional refractive index distribution of semi-transparent samples using multiple measurements of an optical field transmitted through the sample for various illumination directions. The process of assembly of the angular measurements is usually performed with one of two methods: filtered backprojection (FBPJ) or filtered backpropagation (FBPP) tomographic reconstruction algorithm. The former approach, although conceptually very simple, provides an accurate reconstruction for the object regions located close to the plane of focus. However, since FBPJ ignores diffraction, its use for spatially extended structures is arguable. According to the theory of scattering, more precise restoration of a 3D structure shall be achieved with the FBPP algorithm, which unlike the former approach incorporates diffraction. It is believed that with this method one is allowed to obtain a high accuracy reconstruction in a large measurement volume exceeding depth of focus of an imaging system. However, some studies have suggested that a considerable improvement of the FBPP results can be achieved with prior propagation of the transmitted fields back to the centre of the object. This, supposedly, enables reduction of errors due to approximated diffraction formulas used in FBPP. In our view this finding casts doubt on quality of the FBPP reconstruction in the regions far from the rotation axis. The objective of this paper is to investigate limitation of the FBPP algorithm in terms of an off-axis reconstruction and compare its performance with the FBPJ approach. Moreover, in this work we propose some modifications to the FBPP algorithm that allow for more precise restoration of a sample structure in off-axis locations. The research is based on extensive numerical simulations supported with wave-propagation method.

  13. Fracture surface characteristics of off-axis composites

    Sinclair, J. H.; Chamis, C. C.


    The fracture surface characteristics of off-axis high-modulus graphite-fiber/epoxy composite specimens were studied using a scanning electron microscope (SEM). The specimens were subjected to tensile loading at various angles (0-90 deg) to the fiber direction. SEM photomicrographs of the fractured surfaces revealed three different load angle regions with distinct fracture characteristics. Based on these revelations, criteria were established which can be used to characterize fracture surfaces with respect to a predominant 'single-stress' fracture mode.

  14. A Generator Perspective on Vertical Axis Wind Turbines

    Bülow, Fredrik


    The wind energy conversion system considered in this thesis is based on a vertical axis wind turbine with a cable wound direct drive PM generator. Diode rectifiers are used to connect several such units to a single DC-bus and a single inverter controls the power flow from the DC-bus to a utility grid. This work considers the described system from a generator perspective i.e. the turbine is primarily seen as a torque and the inverter is seen as a controlled load. A 12 kW VAWT prototype with a ...

  15. Error Model and Accuracy Calibration of 5-Axis Machine Tool

    Fangyu Pan


    Full Text Available To improve the machining precision and reduce the geometric errors for 5-axis machinetool, error model and calibration are presented in this paper. Error model is realized by the theory of multi-body system and characteristic matrixes, which can establish the relationship between the cutting tool and the workpiece in theory. The accuracy calibration was difficult to achieve, but by a laser approach-laser interferometer and laser tracker, the errors can be displayed accurately which is benefit for later compensation.

  16. Role of the lysophosphatidylinositol/GPR55 axis in cancer.

    Falasca, Marco; Ferro, Riccardo


    Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI. Several investigations have demonstrated that the signalling pathways activated by LPI through its receptor GPR55 play a pivotal role in different cancer type. This review focuses on the role of the LPI/GPR55 axis, in particular with regards to its pharmacological potential therapeutic exploitation. PMID:26588872

  17. Resonance acceptor states in single-axis deformed semiconductors

    Odnoblyudov, M A; Yassievich, I N


    The new approach is proposed to the resonance state parameters, making it possible to determine also the probabilities of the resonance scattering and capture probability into the resonance state. It is based on the application of the Fano configuration interaction method. Two different Hamiltonians of the zero approximation are applied for the continuum states and local priming state. The wave functions are plotted by the method, accepted in the common scattering theory. The detailed consideration and concrete calculations for the acceptor resonance states in the single-axis deformed germanium by the pressure along the axes [001] and [111] are carried out

  18. Tilted axis cranking covariant density functional theory and its applications

    Recent progress on tilted axis cranking covariant density functional theory (CDFT) and its applications to nuclear magnetic and antimagnetic rotation are briefly presented. In particular, the magnetic rotation band in 198Pb and the antimagnetic rotational band in 105Cd are discussed. Without any additional parameter, the experimental relation between angular momentum and rotational frequency for the magnetic rotation band in 198Pb as well as the data of B(E2) values for the antimagnetic rotation band in 105Cd are reproduced very well

  19. The diet-microbiota-metabolite axis regulates the host physiology.

    Yamada, Takahiro; Takahashi, Daisuke; Hase, Koji


    The intestinal microbiota has been implicated in a wide range of diseases, including inflammatory bowel disease, obesity and cancer. Food ingredients are considered a major determinant of gut microbial composition, as exemplified by high-fat diet-induced dysbiosis that can affect host physiology. Accumulating studies show that microbial metabolites are key regulators of the intestinal epithelial barrier and gut immunity. In particular, short-chain fatty acids produced by bacterial fermentation of indigestible polysaccharides have profound impacts on host physiology beyond the gut. In this review, we describe the influences of the diet-microbiota-metabolite axis on host physiology, and especially on the immune and metabolic systems. PMID:26970281

  20. On the off-axis tensile test for unidirectional composites

    Nemeth, M. P.; Herakovich, C. T.; Post, D.


    The off axis tensile test was examined experimentally to obtain actual displacement fields over the surface of graphite polyimide coupon specimens. The experimental results were compared with approximate analytical solutions and generated finite element results. An optical method of high sensitivity moire interferometry was used to determine the actual displacements to high precision. The approximate analytical solution and the finite element results compare very favorably with the measured centerline displacements in the test section, and the finite element displacement fields provide excellent agreement with the moire displacements throughout the specimen. A 15 degree fiber orientation and coupon aspect ratios of 5 and 15 are presented.

  1. Asteroid Shape and Spin Axis Modeling Via Light Curve Inversion

    Friz, Paul; Gokhale, V.


    We present light curves and shape and spin axis models for the five asteroids: 291 Alice, 281 Lucretia, 321 Florentina, 714 Ulula, and 3169 Ostro. These models were obtained using data taken from the Truman Observatory, the Asteroid Photometric Catalogue, and the Minor Planet Center. Knowledge of individual asteroids shapes and spin axes is vital to understanding the solar system. However, currently only 213 out of the 500,000 asteroids with known orbits have been modeled. By taking many light curves of asteroids over several apparitions it is possible to determine their shapes and spin axes by a process known as light curve inversion.

  2. The interleukin-20 receptor axis in early rheumatoid arthritis

    Kragstrup, Tue Wenzel; Greisen, Stinne Ravn; Nielsen, Morten Aagaard;


    BACKGROUND: Rheumatoid arthritis (RA) is often characterized by the presence of rheumatoid factor, anti-citrullinated protein antibodies, and bone erosions. Current therapies can compromise immunity, leading to risk of infection. The interleukin-20 receptor (IL-20R) axis comprising IL-19, IL-20...... RA synovial fluid compared with monocytes from both RA and healthy control peripheral blood. The plasma concentrations of IL-20 and IL-24 were increased in rheumatoid factor and anti-citrullinated protein antibody positive compared with negative early RA patients (all P < 0.0001). Immune complexes...

  3. Embedded synaptic feedback in the neuroendocrine stress axis.

    Wamsteeker Cusulin, J I; Bains, J S


    Neural regulation of blood glucocorticoid levels is critical for defence of homeostasis during physiological or psychoemotional challenges. In mammals, this function is carried out by the neuroendocrine stress axis, coordinated by parvocellular neuroendocrine cells (PNCs) of the paraventricular hypothalamic nucleus. Feedback regulation of PNCs by glucocorticoids provides complex experience-dependent shaping of neuroendocrine responses. We review recent evidence for metaplastic actions of glucocorticoids as 'circuit breakers' at synapses directly regulating PNC excitability and explore how such mechanisms may serve as substrates for stress adaptation. PMID:25612538

  4. Fabrication of Dual-Axis Solar Tracking Controller Project

    Nader Barsoum


    The recent decades have seen the increase in demand for reliable and clean form of electricity derived from renewable energy sources. One such example is solar power. The challenge remains to maximize the capture of the rays from the sun for conversion into electricity. This paper presents fabrication and installation of a solar panel mount with a dual-axis solar tracking controller. This is done so that rays from the sun fall perpendicularly unto the solar panels to maximize the capture of t...

  5. Microwave metal disk antenna with axis-symmetric excitation

    I. Ivanchenko; A. Korolev; Karelin, S.; Laz'ko, E.; Lukyanova, N.; N. Popenko


    The paper presents a microwave metal disk antenna with axis-symmetric excitation operating in the TM010 mode. Experimental investigations of the input characteristics of the antenna, and of the near-fields and the radiation pattern, have been performed. It was shown that the antenna forms a conical radiation pattern, oriented 36° to the zenith, and has a bandwidth of 18% that can be evaluated as a record for antennas of this kind. The antenna also has a level of side radiation as well as a cr...

  6. Low Reynolds number airfoils for small horizontal axis wind turbines

    Giguere, Philippe; Selig, Michael S. [University of Illinois at Urbana-Chanpaign (United States). Dept. of Aeronautical and Astronautical Engineering


    To facilitate the airfoil selection process for small horizontal-axis wind turbines, an extensive database of low Reynolds number airfoils has been generated. The database, which consists of lift and drag data, was obtained from experiments conducted in the same wind tunnel testing facility. Experiments with simulated leading-edge roughness were also performed to model the effect of blade erosion and the accumulation of roughness elements, such as insect debris, on airfoil performance. Based on the lift curves and drag polars, guidelines that should be useful in selecting appropriate airfoils for particular blade designs are given. Some of these guidelines are also applicable to larger HAWTs. (author)

  7. Resonances and Aerodynamic Damping of a Vertical Axis Wind Turbine

    Ottermo, Fredric; Bernhoff, Hans


    The dynamics of a straight-bladed vertical axis wind turbine is investigated with respect to oscillations due to the elasticity of struts and shaft connecting to the hub. In particular, for the three-bladed turbine, a concept is proposed for dimensioning the turbine to maximize the size of the resonance free rpm range for operation. The effect of aerodynamic damping on the struts is also considered. The damping of these types of oscillations for a typical turbine is found to be good.

  8. IL-33/ST2 axis in inflammation and immunopathology.

    Milovanovic, Marija; Volarevic, Vladislav; Radosavljevic, Gordana; Jovanovic, Ivan; Pejnovic, Nada; Arsenijevic, Nebojsa; Lukic, Miodrag L


    Interleukin-33 (IL-33), a member of the IL-1 family of cytokines, binds to its plasma membrane receptor, heterodimeric complex consisted of membrane-bound ST2L and IL-1R accessory protein, inducing NFkB and MAPK activation. IL-33 exists as a nuclear precursor and may act as an alarmin, when it is released after cell damage or as negative regulator of NFκB gene transcription, when acts in an intracrine manner. ST2L is expressed on several immune cells: Th2 lymphocytes, NK, NKT and mast cells and on cells of myeloid lineage: monocytes, dendritic cells and granulocytes. IL-33/ST2 axis can promote both Th1 and Th2 immune responses depending on the type of activated cell and microenvironment and cytokine network in damaged tissue. We previously described and discuss here the important role of IL-33/ST2 axis in experimental models of type 1 diabetes, experimental autoimmune encephalomyelitis, fulminant hepatitis and breast cancer. We found that ST2 deletion enhance the development of T cell-mediated autoimmune disorders, EAE and diabetes mellitus type I. Disease development was accompanied by dominantly Th1/Th17 immune response but also higher IL-33 production, which suggest that IL-33 in receptor independent manner could promote the development of inflammatory autoreactive T cells. IL-33/ST2 axis has protective role in Con A hepatitis. ST2-deficient mice had more severe hepatitis with higher influx of inflammatory cells in liver and dominant Th1/Th17 systemic response. Pretreatment of mice with IL-33 prevented Con A-induced liver damage through prevention of apoptosis of hepatocytes and Th2 amplification. Deletion of IL-33/ST2 axis enhances cytotoxicity of NK cells, production of IFN-γ in these cells and systemic production of IFN-γ, IL-17 and TNF-α, which leads to attenuated tumor growth. IL-33 treatment of tumor-bearing mice suppresses activity of NK cells, dendritic cell maturation and enhances alternative activation of macrophages. In conclusion, we observed

  9. A novel multi-axis force sensor for microrobotics applications

    High performance force sensors often encounter the conflicting requirements of fine sensitivity and wide bandwidth. While there is an intrinsic tradeoff between these two metrics that cannot be physically avoided for any force transducer, through proper optimization the product of these two can be maximized. Similarly, the requirements of multiple sensing axes and overall compactness are also often at odds. This paper describes a novel design, simple method of fabrication, and thorough analysis of a high performance two-axis force sensor. We conclude with an example application: measuring the lift and drag forces from a flapping-wing robotic insect

  10. The cathode test stand for the DARHT second-axis

    The injector for the DARHT second-axis injector will use an 8-in. thermionic dispenser cathode. Because the cathode is relatively large and requires a large amount of heat (5 kW) there are certain engineering issues that need to be addressed, before the DARHT injector reaches the final design stage. The Cathode Test Stand (CTS) will be used to address those concerns. The CTS is a new facility, presently under construction. The CTS will consist of a high-voltage pulse modulator, a high-vacuum diode test-chamber, and a short beam-transport section with diagnostics. This paper discusses the status of the project

  11. Experimental characterization of vertical-axis wind turbine noise.

    Pearson, C E; Graham, W R


    Vertical-axis wind turbines are wind-energy generators suitable for use in urban environments. Their associated noise thus needs to be characterized and understood. As a first step, this work investigates the relative importance of harmonic and broadband contributions via model-scale wind-tunnel experiments. Cross-spectra from a pair of flush-mounted wall microphones exhibit both components, but further analysis shows that the broadband dominates at frequencies corresponding to the audible range in full-scale operation. This observation has detrimental implications for noise-prediction reliability and hence also for acoustic design optimization. PMID:25618090

  12. Wake-Assisted Windmill System with Parallel Vertical-Axis

    YAMAGISHI, Masaki; Sato, Daisuke; MIYASHITA, Jun; Nozaki, Kentaro; 山岸, 真幸; 佐藤, 大資; 宮下, 准; 野崎, 健太郎


    For the improvement of the performance of drag-type windmills with vertical-axis, the experimental study proposed the windmill system using the wake behind a bluff body. The model windmill has two Savonius rotors that were set in parallel behind the circular cylinder. Through the wind tunnel experiment the revolution of the rotor of the windmill system was compared with that of the single rotor. The revolution of the windmill system was found higher than that of the single rotor. Also the opt...

  13. Axis-1 diode simulations I: standard 2-inch cathode

    Ekdahl, Carl [Los Alamos National Laboratory


    The standard configuration of the DARHT Axis-I diode features a 5.08-cm diameter velvet emitter mounted in the flat surface of the cathode shroud. The surface of the velvet is slightly recessed {approx}2.5 mm. This configuration produces a 1.75 kA beam when a 3.8-MV pulse is applied to the anode-cathode (AK) gap. This note addresses some of the physics of this diode through the use of finite-element simulations.

  14. Design of h-Darrieus vertical axis wind turbine

    Parra Teresa; Vega Carmen; Gallegos A.; Uzarraga N. C.; Castro F.


    Numerical simulation is used to predict the performance of a Vertical Axis Wind Turbine (VAWT) H-Darrieus. The rotor consists of three straight blades with shape of aerofoil of the NACA family attached to a rotating vertical shaft. The influence of the solidity is tested to get design tendencies. The mesh has two fluid volumes: one sliding mesh for the rotor where the rotation velocity is established while the other is the environment of the rotor. Bearing in mind the overall flow is characte...

  15. Wake Development of a Model Vertical Axis Wind Turbine

    Kadum, Hawwa; Friedman, Sasha; Camp, Elizabeth; Cal, Rau'l.


    At the Portland State University wind tunnel facility, an experiment is conducted to observe the downstream development of the wake past a model vertical axis wind turbine (VAWT). The flow domain is composed of streamwise-spanwise planes at mid-height of the VAWT rotor and data is obtained via particle image velocimetry (PIV). The flow field is assessed by analyzing contours of mean velocities and the full Reynolds stress tensor. Furthermore, profiles of the aforementioned quantities and flow parameters are discussed in the context of downstream evolution/flow development.

  16. Electric power from vertical-axis wind turbines

    Touryan, K. J.; Strickland, J. H.; Berg, D. E.


    Significant advancements have occurred in vertical axis wind turbine (VAWT) technology for electrical power generation over the last decade; in particular, well-proven aerodynamic and structural analysis codes have been developed for Darrieus-principle wind turbines. Machines of this type have been built by at least three companies, and about 550 units of various designs are currently in service in California wind farms. Attention is presently given to the aerodynamic characteristics, structural dynamics, systems engineering, and energy market-penetration aspects of VAWTs.

  17. Large Eddy Simulation of Vertical Axis Wind Turbine Wakes

    Sina Shamsoddin; Fernando Porté-Agel


    In this study, large eddy simulation (LES) is combined with a turbine model to investigate the wake behind a vertical-axis wind turbine (VAWT) in a three-dimensional turbulent flow. Two methods are used to model the subgrid-scale (SGS) stresses: (a) the Smagorinsky model; and (b) the modulated gradient model. To parameterize the effects of the VAWT on the flow, two VAWT models are developed: (a) the actuator swept-surface model (ASSM), in which the time-averaged turbine-induced forces are dis...

  18. A 34-meter VAWT (Vertical Axis Wind Turbine) point design

    Ashwill, T. D.; Berg, D. E.; Dodd, H. M.; Rumsey, M. A.; Sutherland, H. J.; Veers, P. S.

    The Wind Energy Division at Sandia National Laboratories recently completed a point design based on the 34-m Vertical Axis Wind Turbine (VAWT) Test Bed. The 34-m Test Bed research machine incorporates several innovations that improve Darrieus technology, including increased energy production, over previous machines. The point design differs minimally from the Test Bed; but by removing research-related items, its estimated cost is substantially reduced. The point design is a first step towards a Test-Bed-based commercial machine that would be competitive with conventional sources of power in the mid-1990s.

  19. Effect of Relative Marker Movement on the Calculation of the Foot Torsion Axis Using a Combined Cardan Angle and Helical Axis Approach

    Graf, Eveline S.; Wright, Ian C.; Stefanyshyn, Darren J.


    The two main movements occurring between the forefoot and rearfoot segment of a human foot are flexion at the metatarsophalangeal joints and torsion in the midfoot. The location of the torsion axis within the foot is currently unknown. The purpose of this study was to develop a method based on Cardan angles and the finite helical axis approach to calculate the torsion axis without the effect of flexion. As the finite helical axis method is susceptible to error due to noise with small helical rotations, a minimal amount of rotation was defined in order to accurately determine the torsion axis location. Using simulation, the location of the axis based on data containing noise was compared to the axis location of data without noise with a one-sample t-test and Fisher's combined probability score. When using only data with helical rotation of seven degrees or more, the location of the torsion axis based on the data with noise was within 0.2 mm of the reference location. Therefore, the proposed method allowed an accurate calculation of the foot torsion axis location. PMID:22666303

  20. Research on identifying the dynamic error model of strapdown gyro on 3-axis turntable

    WANG Hai; REN Shun-qing; WANG Chang-hong


    The dynamic errors of gyros are the important error sources of a strapdown inertial navigation system.In order to identify the dynamic error model coefficients accurately, the static erTor model coefficients which lay a foundation for compensating while identifying the dynamic error model are identified in the gravity acceleration fields by using angular position function of the three-axis turntable. The angular acceleration and angular velocity are excited on the input, output and spin axis of the gyros when the outer axis and the middle axis of a threeaxis turntable are in the uniform angular velocity state simultaneously, while the inner axis of the turntable is in different static angular positions. 8 groups of data are sampled when the inner axis is in 8 different angular positions. These data are the function of the middle axis positions and the inner axis positions. For these data, harmonic analysis method is applied two times versus the middle axis positions and inner axis positions respectively so that the dynamic error model coefficients are finally identified through the least square method. In the meantime the optimal angular velocity of the outer axis and the middle axis are selected by computing the determination value of the information matrix.

  1. Modeling the brain-pituitary-gonad axis in salmon

    Kim, Jonghan; Hayton, William L.; Schultz, Irv R.


    To better understand the complexity of the brain-pituitary-gonad axis (BPG) in fish, we developed a biologically based pharmacodynamic model capable of accurately predicting the normal functioning of the BPG axis in salmon. This first-generation model consisted of a set of 13 equations whose formulation was guided by published values for plasma concentrations of pituitary- (FSH, LH) and ovary- (estradiol, 17a,20b-dihydroxy-4-pregnene-3-one) derived hormones measured in Coho salmon over an annual spawning period. In addition, the model incorporated pertinent features of previously published mammalian models and indirect response pharmacodynamic models. Model-based equations include a description of gonadotropin releasing hormone (GnRH) synthesis and release from the hypothalamus, which is controlled by environmental variables such as photoperiod and water temperature. GnRH stimulated the biosynthesis of mRNA for FSH and LH, which were also influenced by estradiol concentration in plasma. The level of estradiol in the plasma was regulated by the oocytes, which moved along a maturation progression. Estradiol was synthesized at a basal rate and as oocytes matured, stimulation of its biosynthesis occurred. The BPG model can be integrated with toxico-genomic, -proteomic data, allowing linkage between molecular based biomarkers and reproduction in fish.

  2. Stable three-axis nuclear-spin gyroscope in diamond

    Ajoy, Ashok; Cappellaro, Paola


    Gyroscopes find wide applications in everyday life from navigation and inertial sensing to rotation sensors in hand-held devices and automobiles. Current devices, based on either atomic or solid-state systems, impose a choice between long-time stability and high sensitivity in a miniaturized system. Here, we introduce a quantum sensor that overcomes these limitations by providing a sensitive and stable three-axis gyroscope in the solid state. We achieve high sensitivity by exploiting the long coherence time of the 14N nuclear spin associated with the nitrogen-vacancy center in diamond, combined with the efficient polarization and measurement of its electronic spin. Although the gyroscope is based on a simple Ramsey interferometry scheme, we use coherent control of the quantum sensor to improve its coherence time and robustness against long-time drifts. Such a sensor can achieve a sensitivity of η˜0.5(mdegs-1)/Hzmm3 while offering enhanced stability in a small footprint. In addition, we exploit the four axes of delocalization of the nitrogen-vacancy center to measure not only the rate of rotation, but also its direction, thus obtaining a compact three-axis gyroscope.

  3. Related Axis: The Extension to XPath Towards Effective XML Search

    Jun-Feng Zhou; Tok Wang Ling; Zhi-Feng Bao; Xiao-Feng Meng


    We investigate the limitations of existing XML search methods and propose a new semantics,related relationship,to effectively capture meaningful relationships of data elements from XML data in the absence of structural constraints.Then we make an extension to XPath by introducing a new axis,related axis,to specify the related relationship between query nodes so as to enhance the flexibility of XPath.We propose to reduce the cost of computing the related relationship by a new schema summary that summarizes the related relationship from the original schema without any loss.Based on this schema summary,we introduce two indices to improve the performance of query processing.Our algorithm shows that the evaluation of most queries can be equivalently transformed into just a few selection and value join operations,thus avoids the costly structural join operations.The experimental results show that our method is effective and efficient in terms of comparing the effectiveness of the related relationship with existing keyword search semantics and comparing the efficiency of our evaluation methods with existing query engines.

  4. On the spin-axis dynamics of a Moonless Earth

    Li, Gongjie; Batygin, Konstantin, E-mail: [Harvard-Smithsonian Center for Astrophysics, The Institute for Theory and Computation, 60 Garden Street, Cambridge, MA 02138 (United States)


    The variation of a planet's obliquity is influenced by the existence of satellites with a high mass ratio. For instance, Earth's obliquity is stabilized by the Moon and would undergo chaotic variations in the Moon's absence. In turn, such variations can lead to large-scale changes in the atmospheric circulation, rendering spin-axis dynamics a central issue for understanding climate. The relevant quantity for dynamically forced climate change is the rate of chaotic diffusion. Accordingly, here we re-examine the spin-axis evolution of a Moonless Earth within the context of a simplified perturbative framework. We present analytical estimates of the characteristic Lyapunov coefficient as well as the chaotic diffusion rate and demonstrate that even in absence of the Moon, the stochastic change in Earth's obliquity is sufficiently slow to not preclude long-term habitability. Our calculations are consistent with published numerical experiments and illustrate the putative system's underlying dynamical structure in a simple and intuitive manner.

  5. Rotation axis demultiplexer enabling simultaneous computed tomography of multiple samples.

    Trtik, Pavel; Geiger, Fabian; Hovind, Jan; Lang, Udo; Lehmann, Eberhard; Vontobel, Peter; Peetermans, Steven


    This paper describes a device that allows for simultaneous tomographic imaging of samples on three independent rotational axes. This rotation axis demultiplexer (POLYTOM) is equipped with anti-backlash gears and placed on a standard sample rotation stage thus allowing for the transformation of the input rotation axis onto two additional parallel vertical axes. Consequently, three times the number of samples can be investigated within a given time period, thereby reducing the acquisition time of multiple sample tomographic investigations by a factor of three. The results of our pilot experiments using neutron tomographic imaging are presented. We foresee that the device will be of particular use for tomographic imaging of elongated samples at low-flux (e.g. neutron) sources; however, its use for the more widespread types of imaging techniques (e.g. X-rays) is not ruled out. The highlights of this new device for the purpose of the (neutron) computed tomography are: •Anti-backlash transformation of the input rotation onto two additional rotational axes.•Reduction of the acquisition time of the multiple sample tomographic investigations by a factor of three.•Low-cost. PMID:27158597

  6. PRIGo: a new multi-axis goniometer for macromolecular crystallography

    The design and performance of the new multi-axis goniometer PRIGo developed at the Swiss Light Source at Paul Scherrer Institute is described. The Parallel Robotics Inspired Goniometer (PRIGo) is a novel compact and high-precision goniometer providing an alternative to (mini-)kappa, traditional three-circle goniometers and Eulerian cradles used for sample reorientation in macromolecular crystallography. Based on a combination of serial and parallel kinematics, PRIGo emulates an arc. It is mounted on an air-bearing stage for rotation around ω and consists of four linear positioners working synchronously to achieve x, y, z translations and χ rotation (0–90°), followed by a ϕ stage (0–360°) for rotation around the sample holder axis. Owing to the use of piezo linear positioners and active correction, PRIGo features spheres of confusion of <1 µm, <7 µm and <10 µm for ω, χ and ϕ, respectively, and is therefore very well suited for micro-crystallography. PRIGo enables optimal strategies for both native and experimental phasing crystallographic data collection. Herein, PRIGo hardware and software, its calibration, as well as applications in macromolecular crystallography are described

  7. Miniature image guided three-axis scanning and positioning system

    Avirovik, Dragan; Dave, Digant; Priya, Shashank


    We have developed a high precision three axes scanning and positioning system for integration with Multifunctional Image Guided Surgical (MIGS) Platform. The stage integrates three main components: an optical coherence tomography (OCT) probe, laser scalpel and suction cup. The requirements for this stage were to provide scanning area of 400mm2, resolution of less than 10 microns and scanning velocity in the range of 10 - 40 mm/s. The stage was modeled using computer aided design software NX Unigraphics. In addition to the parameters mentioned above, additional boundary conditions for the stage were set as low volume and modularity. Optimized stage model was fabricated by using rapid prototyping technique that integrates low cost stepper motors, threaded rod drive train and a stepper motor controller. The EZ4axis stepper motor controller was able to provide 1/8th microstep resolution control over the motors, which met the criterion desired for the MIGS platform. Integration of computer controlled three-axis stage with MIGS platform provides the opportunity for conducting intricate surgical procedures using remote control or joystick. The device is image guided using the OCT probe and it is able to pin point any location requiring a laser scalpel incision. Due to the scanning capabilities, a high quality threedimensional image of the tissue topography is obtained which allows the surgeon to make a confident decision of where to apply the laser scalpel and make an incision.

  8. Microcontroller based two axis microtron beam extraction system

    Microtron is an electron accelerator which is used to accelerate the electron beam. The Microtron consists of electro magnet with two poles separated by yoke for completion of path for magnetic flux lines. A compact Microtron capable of accelerating electrons up to 12 MeV has been developed in RRCAT. The beam from the Microtron has to be extracted from various orbits depending upon the user requirement (X-Y stage is built with an accuracy of 100 μm). This paper describes the design and development of microcontroller based two axis beam extraction system for Microtron, with a resolution of 50 μm to position the extraction tube with respect to selected orbit. Two axis motion controller is developed using current controlled micro-stepping driver mechanism, which uses Bipolar Chopper Drive for driving stepper motors. Each phase has 2A continuous driving capability. The system is provided with user selectable controls like speed, steps, direction, and mode. This system is provided with RS-232 interface, to accept commands from PC. This system also has local keyboard and LCD interface to use in Stand-alone mode (local Mode). (author)

  9. Harnessing Tidal Energy Using Vertical Axis Tidal Turbine

    Syed Shah Khalid


    Full Text Available An overview of the current design practices in the field of Renewable Energy (RE is presented; also paper delineates the background to the development of unique and novel techniques for power generation using the kinetic energy of tidal streams and other marine currents. Also this study focuses only on vertical axis tidal turbine. Tidal stream devices have been developed as an alternative method of extracting the energy from the tides. This form of tidal power technology poses less threat to the environment and does not face the same limiting factors associated with tidal barrage schemes, therefore making it a more feasible method of electricity production. Large companies are taking interest in this new source of power. There is a rush to research and work with this new energy source. Marine scientists are looking into how much these will affect the environment, while engineers are developing turbines that are harmless for the environment. In addition, the progression of technological advancements tracing several decades of R & D efforts on vertical axis turbines is highlighted.

  10. Three-axis positional drift correction in scanning probe microscopy

    Follin, Nathan D.; Musalo, Christopher J.; Trawick, Matthew L.


    Positional drift in scanning probe microscopy can cause image distortion and metrological errors of tens of nanometers or more. It can arise from thermal drift, due to thermal expansion of materials in the sample and microscope while scanning, or from piezo creep, particularly along the z axis. We present a technique for correcting positional drift errors in all three axes. Our method works by comparing each scanned topographical image to a second, partial scan, taken immediately afterwards, on which the fast and slow scan axes have been reversed. We model the positional distortion as a low-order polynomial function in three dimensions, searching for the set of correctional coefficients that minimizes the difference between the two scans. Using this technique we have successfully reduced positional errors from 50 nm to 0.5 nm in the z axis, and from 40 nm to 2 nm (about half of a single pixel) in the xy plane. Supported by an award from Research Corporation for Science Advancement, and by the American Chemical Society Petroleum Research Fund through Grant number 46380-GB7.