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Sample records for atrs world conference

  1. The Conference Proceedings of the 2003 Air Transport Research Society (ATRS) World Conference, Volume 3

    Science.gov (United States)

    Bowen, Brent (Editor); Gudmundsson, Sveinn (Editor); Oum, Tae (Editor)

    2003-01-01

    Volume 3 of the 2003 Air Transport Reserch Society (ATRS) World Conference includes papers on topics relevant to airline operations worldwide. Specific topics include: European Union and civil aviation regimens;simulating decision making in airline operations, passenger points of view on convenient airports; route monopolies and nonlinear pricing; cooperation among airports in Europe; fleet modernizaiton in Brazil;the effects of deregulation on the growth of air transportation in Europe and the United States.

  2. The Conference Proceedings of the 2003 Air Transport Research Society (ATRS) World Conference, Volume 5

    Science.gov (United States)

    Bowen, Brent (Editor); Gudmundsson, Sveinn (Editor); Oum, Tae (Editor)

    2003-01-01

    The UNO Aviation Institute Monograph Series began in 1994 as a key component of the education outreach and information transfer missions of the Aviation Institute and the NASA Nebraska Space Grant & EPSCoR Programs. The series is an outlet for aviation materials to be indexed and disseminated through an efficient medium. Publications are welcome in all aspects of aviation. Publication formats may include, but are not limited to, conference proceedings, bibliographies, research reports, manuals, technical reports, and other documents that should be archived and indexed for future reference by the aviation and world wide communities. The Conference proceedings of the 2003 Air Transport Research Society (ATRS) world conference, volume 5 is presented. The topics include: 1) The Temporal Configuration of Airline Networks in Europe; 2) Determination and Applications of Environmental Costs at Different Sized Airports-Aircraft Noise and Engine Emissions; 3) Cost Effective Measures to Reduce CO2 Emissions in the Air Freight Sector; 4) An Assessment of the Sustainability of Air Transport System: Quantification of Indicators; 5) Regulation, Competition and Network Evolution in Aviation; 6) Regulation in the Air: Price and Frequency Cap; 7) Industry Consolidation and Future Airline Network Structures in Europe; 8) Application of Core Theory to the U.S. Airline Industry; 9) Air Freight Transshipment Route Choice Analysis; 10) A Fuzzy Approach of the Competition on Air Transport Market; and 11) Developing Passenger Demand Models for International Aviation from/to Egypt: A Case Study of Cairo Airport and Egyptair.

  3. The Conference Proceedings of the 2003 Air Transport Research Society (ATRS) World Conference, Volume 2

    Science.gov (United States)

    Bowen, Brent (Editor); Gudmundsson, Sveinn (Editor); Oum, Tae (Editor)

    2003-01-01

    The UNO Aviation Institute Monograph Series began in 1994 as a key component of the education outreach and information transfer missions of the Aviation Institute and the NASA Nebraska Space Grant & EPSCoR Programs. The series is an outlet for aviation materials to be indexed and disseminated through an efficient medium. Publications are welcome in all aspects of aviation. Publication formats may include, but are not limited to, conference proceedings, bibliographies, research reports, manuals, technical reports, and other documents that should be archived and indexed for future reference by the aviation and world wide communities.

  4. World Energy Conference

    International Nuclear Information System (INIS)

    Ott, G.; Schilling, H.D.

    1979-01-01

    After making some general remarks about goals, tasks, and works of the World Energy Conference the topics and the frame of the 11th World Energy Conference which will take place in Munich from 8th to 12th September 1980 are outlined. This conference is held under the general topic 'energy for our world' and deals with the reciprocal relation between energy supply, environment, and society. The main part of the publication presented here is the German version of the most important sections of the investigation 'World Energy-Looking Ahead to 2020' by the Conservation Commission (CC) of the World Energy Conference. Added to this is the German original brief version of a report by the Mining-Research Company (Bergbau-Forschung GmbH) to the CC which deals with the estimation of the world's coal resources and their future availability. This report was presented on the 10th World Energy Conference in Istanbul together with the corresponding reports concerning the other energy sources. Finally, an introduction to the technical programme for the 11th World Energy Conference 1980 is given. (UA) [de

  5. The World Food Conference--A Frustrating First Step

    Science.gov (United States)

    Thomas, Gerald W.

    1975-01-01

    Discusses the positive results of the World Food Conference and the world awareness (aroused by the conference) which is the first step in the solution of world hunger. Some of the positive results are the establishment of the World Food Council, establishment of grain reserves, and a worldwide system of food information. (BR)

  6. The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 1

    Science.gov (United States)

    Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

    2001-01-01

    The ATRS held its Annual conference at Jeju Island, Korea in July 2001. The conference was a success with nearly 140 participants including 70 presenters. This report contains presentations from Volume 1 on the following: Airline and Travel Agent Relationships in Asia;Benchmarking Aviation Safety in the Commercial Airline Industry;Impact of Frequent Flyer Program on the Demand for Air Travel; Application of Genetic Algorithm on Airline Schedule;The Effects of Dual Carrier Designation and Partial Liberalization: The Case of Canada;Defense of Air Carriers and Air Agencies in FAA Enforcement proceedin gs - Damage Control Before the Case Arises; Cost Incentives for Airline Mergers? - An examination on the cost impact of U.S. airline mergers and acquisitions;Airport Regulation, Airline Competition and Canada's Airport System; Airline Competition: The Case of Israel's Domestic Doupoly; Non-Financial Indicators of Airline Distress: A Conceptual Approach;and Airport Privatization: An Empirical Analysis of Financial and Operational Efficiency.

  7. Selected Papers Presented at MODSIM World 2011 Conference and Expo

    Science.gov (United States)

    Pinelli, Thomas E. (Compiler); Bullock, Leanna S. (Compiler)

    2012-01-01

    Selected papers from MODSIM World 2011 Conference & Expo are contained in this NASA Conference Publication (CP). MODSIM World 2011 was held in Virginia Beach, Virginia, October 11-14, 2011. The theme of the 2011 conference & expo was "Overcoming Critical Global Challenges with Modeling & Simulation". The conference program consisted of five technical tracks - Defense, Homeland Security & First Responders; Education; Health & Medicine; The Human Dimension; and Serious Games & Virtual Worlds.

  8. The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 2

    Science.gov (United States)

    Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

    2001-01-01

    The ATRS held its 5th Annual conference at the City University of Hong Kong Campus in July 2001. The conference was a success with nearly 140 participants including 70 presenters. Titles that comprise Volume 2 include: Intelligent Airport Gate Assignment System; A Study on the Effects of the Personality Compatibility to the Job Performance; ITS/CVO Application for Air cargo Transportation in Korea; An Airport as a Logistics and Economic Hub: The Case of Incheon International Airport; The Impact Of Aviation Safety over the Consumer's Behavior; The Integration of China and Taiwan Air Networks for Direct Air Cargo Services; Quality perception and carrier choice in Civil Aviation; Future Trends in Business Travel Decision Making; Cooperation Among German Airports in Europe; Inbound and Outbound Air Passenger Traffic Forecasting between the United States and Selected Asian countries; An Evaluation of Alternative Facilities for Airport Redevelopment using Fuzzy Linguistic Approach; Economic Analysis of Airline Alliances; The Aviation Cooperation between the two Koreas Preparing for the Reunification of the Peninsula; and A Study on the Air Transport Cooperation in Northeast Asia between China, Japan and Korea.

  9. 77 FR 67557 - Special Conditions: ATR-GIE Avions de Transport Regional, Models ATR42-500 and ATR72-212A...

    Science.gov (United States)

    2012-11-13

    ..., Models ATR42-500 and ATR72-212A Airplanes; Aircraft Electronic System Security Protection From... exploited by unauthorized access to airplane systems, data buses, and servers. Therefore, these special... ATR42-500 and ATR72-212A airplanes. 1. Airplane Electronic System Security Protection from Unauthorized...

  10. Selected Papers and Presentations Presented at MODSIM World 2010 Conference Expo. Part 2

    Science.gov (United States)

    Pinelli, Thomas E. (Editor)

    2011-01-01

    MODSIM World 2010 was held in Hampton, Virginia, October 13-15, 2010. The theme of the 2010 conference & expo was "21st Century Decision-Making: The Art of Modeling& Simulation". The conference program consisted of seven technical tracks - Defense, Engineering and Science, Health & Medicine, Homeland Security & First Responders, The Human Dimension, K-20 STEM Education, and Serious Games & Virtual Worlds. Selected papers and presentations from MODSIM World 2010 Conference & Expo are contained in this NASA Conference Publication (CP). Section 8.0 of this CP contains papers from MODSIM World 2009 Conference & Expo that were unavailable at the time of publication of NASA/CP-2010-216205 Selected Papers Presented at MODSIM World 2009 Conference and Expo, March 2010.

  11. Selected Papers and Presentations Presented at MODSIM World 2010 Conference and Expo. Part 1

    Science.gov (United States)

    Pinelli, Thomas E. (Editor)

    2011-01-01

    MODSIM World 2010 was held in Hampton, Virginia, October 13-15, 2010. The theme of the 2010 conference & expo was "21st Century Decision-Making: The Art of Modeling& Simulation". The conference program consisted of seven technical tracks - Defense, Engineering and Science, Health & Medicine, Homeland Security & First Responders, The Human Dimension, K-20 STEM Education, and Serious Games & Virtual Worlds. Selected papers and presentations from MODSIM World 2010 Conference & Expo are contained in this NASA Conference Publication (CP). Section 8.0 of this CP contains papers from MODSIM World 2009 Conference & Expo that were unavailable at the time of publication of NASA/CP-2010-216205 Selected Papers Presented at MODSIM World 2009 Conference and Expo, March 2010.

  12. 11 World power conference

    International Nuclear Information System (INIS)

    Masters, R.

    1981-01-01

    Papers presented to the 11 World power conference ''Power for our peace'' held in Munich in September, 1980 are shortly surveyed. A few papers were devoted to nuclear power, that represents its present- state-of-the-art in the world. Except for the paper presented by experts of the International Energy Agency (IEA) and a number of others, there is carefulness and realism with respect to nuclear power in the most part of the papers; its forecasted growth rates are rather moderate. Even in the IEA paper the total world nuclear installed capacity in 1985 is evaluated about 550 GW, that is substantially smaller earlier evaluations. It is acknowledged that the primary energy production almost in all countries will increase mainly due to nuclear power and coal. But there are no answers to the problems related to management of the nuclear power development and to the public opinion in many countries. It is underlined that the problems of world power supply can be solved only on an international basis [ru

  13. The World Population Conference: an international extravaganza.

    Science.gov (United States)

    Franda, M F

    1974-09-01

    The World Population Conference, held in Bucharest, Romania, August 19-30, 1974 is described. 1287 delegates representing 135 countries, pl us representatives of nongovernmental organizations, participants in related activities, and journalists attended. The task of the delegates was: 1) to decide on procedures; 2) to amend and approve a 20-page World Population Plan of Action (WPPA); and 3) to participate in 3 conference committees on social and economic development, natural resources and the environment, and family and human rights. The major political problem was that 106 of the 148 countries invited considered their population growth rates to be either satisfactory or too slow. The Chinese, Latin Americans, Africans, and the Holy See were opposed to family planning programs and directed most of their criticism toward the U.S. The Chinese and the U.S.S.R. both opposed the WPPA on most key votes, with both influencing much of the Third World. The U.S., Western Europe, Oceania, and most of Asia supported the draft WPPA. When the votes were counted, the draft WPPA had been weakened, although some strong statements favoring government family planning programs were retained. Perhaps the fact that such a conference was actually held is a step in the right direction.

  14. Conference assesses world oil supply scene

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    This paper reports that the Offshore Northern Seas conference heard a number of long term outlooks in Stavanger, Norway, last week, all with the same conclusion: the oil and gas industry needs massive investment if it is to match future demand. Norwegian Prime Minister Gro Harlem Bruntland built her scenario on a doubling of world population every 40 years. Mrs. Bruntland emphasized the growing dependence of the world economy on Middle East developments. Two thirds of the world's oil reserves are in the Persian Gulf region, she said, but only 28% of production comes from there. As the rest of the world depletes its reserves, dependence on Persian Gulf oil will grow

  15. Visions for a sustainable world: A conference on science, technology and social responsibility. Conference report

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    This report summarizes the organization, activities, and outcomes of Student Pugwash USA`s 1992 International Conference, Visions for a Sustainable World: A Conference on Science, Technology and Social Responsibility. The conference was held June 14--20, 1992 at Emory University, and brought together 94 students and over 65 experts from industry, academe, and government. The conference addressed issues ranging from global environmental cooperation to the social impacts of the Human Genome Project to minority concerns in the sciences. It provided a valuable forum for talented students and professionals to engage in critical dialogue on many interdisciplinary issues at the juncture of science, technology and society. The conference challenged students -- the world`s future scientists, engineers, and political leaders -- to think broadly about global problems and to devise policy options that are viable and innovative. The success of the conference in stimulating interest, understanding, and enthusiasm about interdisciplinary global issues is clearly evident from both the participants` feedback and their continued involvement in Student Pugwash USA programs. Six working groups met each morning. The working group themes included: environmental challenges for developing countries; energy options: their social and environmental impact; health care in developing countries; changing dynamics of peace and global security; educating for the socially responsible use of technology; ethics and the use of genetic information. The conference was specifically designed to include mechanisms for ensuring its long-term impact. Participants were encouraged to focus on their individual role in helping resolve global issues. This was achieved through each participant`s development of a Personal Plan of Action, a plan which mapped out activities the student could undertake after the conference to continue the dialogue and work towards the resolution of global and local problems.

  16. 17th Online World Conference on Soft Computing in Industrial Applications

    CERN Document Server

    Krömer, Pavel; Köppen, Mario; Schaefer, Gerald

    2014-01-01

    This volume of Advances in Intelligent Systems and Computing contains accepted papers presented at WSC17, the 17th Online World Conference on Soft Computing in Industrial Applications, held from December 2012 to January 2013 on the Internet. WSC17 continues a successful series of scientific events started over a decade ago by the World Federation of Soft Computing. It brought together researchers from over the world interested in the ever advancing state of the art in the field. Continuous technological improvements make this online forum a viable gathering format for a world class conference. The aim of WSC17 was to disseminate excellent research results and contribute to building a global network of scientists interested in both theoretical foundations and practical applications of soft computing.   The 2012 edition of the Online World Conference on Soft Computing in Industrial Applications consisted of general track and special session on Continuous Features Discretization for Anomaly Intrusion Detectors...

  17. The World Power Conference and atomic energy

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1962-01-15

    The possibility that emerged after the last World War that useful power could be produced from nuclear fission led to optimistic estimates that nuclear power would prove to be the solution to the world's energy problems. The possible advantages of nuclear methods of power production compared with conventional means are discussed at the World Power Conference. The 1962 Conference with its theme 'The Changing Pattern of Power' will undoubtedly attract great interest in a world where the change-over from conventional to nuclear fuels for power production has started in some countries and is being actively examined in others. It is generally being realized that even though a country may possess indigenous supplies of uranium or thorium minerals, the building up of a nuclear industry i s a long and expensive process and the alternative of depending on countries more advanced in nuclear technology for the supply of materials, skill and know-how is costly in foreign exchange and international prestige. Many of the industrialized countries, still possessing supplies of conventional fuels, are preparing for the day when their reserves will become depleted and are embarking on training schemes to ensure a continuing supply of engineers and scientists skilled in nuclear arts

  18. ATR performance modeling concepts

    Science.gov (United States)

    Ross, Timothy D.; Baker, Hyatt B.; Nolan, Adam R.; McGinnis, Ryan E.; Paulson, Christopher R.

    2016-05-01

    Performance models are needed for automatic target recognition (ATR) development and use. ATRs consume sensor data and produce decisions about the scene observed. ATR performance models (APMs) on the other hand consume operating conditions (OCs) and produce probabilities about what the ATR will produce. APMs are needed for many modeling roles of many kinds of ATRs (each with different sensing modality and exploitation functionality combinations); moreover, there are different approaches to constructing the APMs. Therefore, although many APMs have been developed, there is rarely one that fits a particular need. Clarified APM concepts may allow us to recognize new uses of existing APMs and identify new APM technologies and components that better support coverage of the needed APMs. The concepts begin with thinking of ATRs as mapping OCs of the real scene (including the sensor data) to reports. An APM is then a mapping from explicit quantized OCs (represented with less resolution than the real OCs) and latent OC distributions to report distributions. The roles of APMs can be distinguished by the explicit OCs they consume. APMs used in simulations consume the true state that the ATR is attempting to report. APMs used online with the exploitation consume the sensor signal and derivatives, such as match scores. APMs used in sensor management consume neither of those, but estimate performance from other OCs. This paper will summarize the major building blocks for APMs, including knowledge sources, OC models, look-up tables, analytical and learned mappings, and tools for signal synthesis and exploitation.

  19. World Conference on Acoustic Emission 2013

    CERN Document Server

    Wu, Zhanwen; Zhang, Junjiao

    2015-01-01

    This volume collects the papers from the 2013 World Conference on Acoustic Emission in Shanghai. The latest research and applications of Acoustic Emission (AE) are explored, with particular emphasis on detecting and processing of AE signals, development of AE instrument and testing standards, AE of materials, engineering structures and systems, including the processing of collected data and analytical techniques as well as experimental case studies.

  20. World Conference on Acoustic Emission 2015

    CERN Document Server

    Wu, Zhanwen; Zhang, Junjiao

    2017-01-01

    This volume collects the papers from the World Conference on Acoustic Emission 2015 (WCAE-2015) in Hawaii. The latest research and applications of Acoustic Emission (AE) are explored, with particular emphasis on detecting and processing of AE signals, development of AE instrument and testing standards, AE of materials, engineering structures and systems, including the processing of collected data and analytical techniques as well as experimental case studies.

  1. Function of the ATR N-terminal domain revealed by an ATM/ATR chimera

    International Nuclear Information System (INIS)

    Chen Xinping; Zhao Runxiang; Glick, Gloria G.; Cortez, David

    2007-01-01

    The ATM and ATR kinases function at the apex of checkpoint signaling pathways. These kinases share significant sequence similarity, phosphorylate many of the same substrates, and have overlapping roles in initiating cell cycle checkpoints. However, they sense DNA damage through distinct mechanisms. ATR primarily senses single stranded DNA (ssDNA) through its interaction with ATRIP, and ATM senses double strand breaks through its interaction with Nbs1. We determined that the N-terminus of ATR contains a domain that binds ATRIP. Attaching this domain to ATM allowed the fusion protein (ATM*) to bind ATRIP and associate with RPA-coated ssDNA. ATM* also gained the ability to localize efficiently to stalled replication forks as well as double strand breaks. Despite having normal kinase activity when tested in vitro and being phosphorylated on S1981 in vivo, ATM* is defective in checkpoint signaling and does not complement cellular deficiencies in either ATM or ATR. These data indicate that the N-terminus of ATR is sufficient to bind ATRIP and to promote localization to sites of replication stress

  2. Vancouver AIDS conference: special report. A verdict on the conference: sadly, not one world or one hope.

    Science.gov (United States)

    Whiteside, A

    1996-01-01

    Although the theme of the 11th International Conference on AIDS held in Vancouver during July 7-12, 1996, was "One World, One Hope," developed and developing countries have HIV/AIDS epidemics of different magnitudes, different levels of resources with which to combat the problems, and dissimilar objectives. The latest data released at the conference report an estimated 21.8 million people to be currently living with HIV/AIDS, the vast majority of whom live in developing countries. 84% of the estimated 7.7 million AIDS cases which have occurred since the beginning of the pandemic were in Africa or Asia; only 9% were in Europe and the US. The greatest burden of disease is and will be therefore experienced in the developing world which, relative to the developed world, has extremely limited resources. The epidemic continues to spread throughout much of the developing world, while levels of HIV infection in the developed world are largely remaining constant, with the center seemingly moving more into marginalized groups such as the homeless, drug users, and other groups. A whole range of new drugs will soon be available to treat HIV/AIDS among those who can afford them. It is possible that AIDS may simply become manageable as a chronic illness in the west. Such drugs, however, will be prohibitively expensive for almost all people infected with HIV. Moreover, the side effects of these new drugs remain to be seen, and it is possible that individuals will develop resistance to the treatment. The author laments the lack of papers at the conference analyzing the impact of the epidemic and hopes to see more representation and consideration of the developing world at the next conference, to be held in Geneva in 1998.

  3. The 1992 World Administrative Radio Conference: Technology and Policy Implications

    Science.gov (United States)

    1993-05-01

    As the 20th century draws to a close, new radio technologies and services are poised to change the ways we communicate. Radio waves already make possible a wide range of services considered commonplace--AM and FM radio broadcasting, television, cellular telephones, remote garage-door openers, and baby monitors. Advances in radio technology are giving birth to even more new products and services, including pocket-sized telephones that may allow people to make and receive calls anywhere in the world, high-definition televisions (HDTV) with superior quality pictures and sound, and static-free digital radios. The 1992 World Administrative Radio Conference (WARC-92) authorized frequencies for many of these new radio communication services, and granted additional frequencies for many existing services, including international broadcasting, satellite-based mobile communications, and communications in space. The effects of these changes will be felt well into the 21st century as countries around the world develop and deploy new communications systems to serve the needs of consumers, businesses, and governments. For the United States, the decisions made at the conference will critically affect how we develop new radio technologies and applications, how competitive this country will be in radio communications equipment and services, and how effectively the United States can exercise its role as a leader in world radio communication policymaking. This study of the outcomes and implications of WARC-92 was requested by the House Committee on Energy and Commerce and the Senate Committee on Commerce, Science, and Transportation. OTA was asked to evaluate the success of U.S. proposals at the conference, discuss the implications of the decisions made for U.S. technology and policy development, and identify options for improving U.S. participation in future world radio communication conferences.

  4. More than just a conference : the European Particule Accelerator Conference, EPAC, has developped a distinctive role on the world stage, explains Christine Petit-Jean-Genaz, the EPAC conferences coordinator

    CERN Multimedia

    Maximilien Brice

    2004-01-01

    More than just a conference : the European Particule Accelerator Conference, EPAC, has developped a distinctive role on the world stage, explains Christine Petit-Jean-Genaz, the EPAC conferences coordinator

  5. [4th World Conference on Women].

    Science.gov (United States)

    1995-06-01

    The World Platform of Action is a document prepared by the secretary of the UN Commission on the Status of Women (CSW) that acknowledges commitments made by the subscribing governments. In the final preparatory meeting for the Fourth International Conference on Women in Beijing, official delegations of the world's governments discussed the draft of the Platform of Action. Throughout the Platform, there is evidence of a retreat from concepts internationally recognized at other conferences. The Vatican, in alliance with countries like Honduras, Argentina, and Guatemala, and with fundamentalist religious groups, is largely responsible for the obstruction. The draft indicates which topics have failed to gain consensus and require discussion at the full Conference. The Platform is defined as an agenda for seeking empowerment of women, an objective necessitating removal of obstacles to active participation by women in all spheres of public life. The Platform defines the critical areas for action as the persistent increase in poverty among women, unequal access to education and training, unequal access to health care, violence against women and girls, effects of persecution and armed conflicts, unequal access to productive processes, and unequal power and influence in decision making at all levels. Insufficient mechanisms for promoting women, protection of the human rights of women, women and communication, and women and the environment are other priority topics. Problems are discussed in each of these areas, and objectives and concrete actions are proposed. The work describes the types of institutional changes that will be needed if the objectives are to be achieved; defines sex, gender, and other relevant terms; and analyses some of the strategic objectives in greater detail. The final section contains recommendations for women's groups and other lobbyists in Colombia to present to the government.

  6. ATR neutron spectral characterization

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, J.W.; Anderl, R.A.

    1995-11-01

    The Advanced Test Reactor (ATR) at INEL provides intense neutron fields for irradiation-effects testing of reactor material samples, for production of radionuclides used in industrial and medical applications, and for scientific research. Characterization of the neutron environments in the irradiation locations of the ATR has been done by means of neutronics calculations and by means of neutron dosimetry based on the use of neutron activation monitors that are placed in the various irradiation locations. The primary purpose of this report is to present the results of an extensive characterization of several ATR irradiation locations based on neutron dosimetry measurements and on least-squares-adjustment analyses that utilize both neutron dosimetry measurements and neutronics calculations. This report builds upon the previous publications, especially the reference 4 paper. Section 2 provides a brief description of the ATR and it tabulates neutron spectral information for typical irradiation locations, as derived from the more historical neutron dosimetry measurements. Relevant details that pertain to the multigroup neutron spectral characterization are covered in section 3. This discussion includes a presentation on the dosimeter irradiation and analyses and a development of the least-squares adjustment methodology, along with a summary of the results of these analyses. Spectrum-averaged cross sections for neutron monitoring and for displacement-damage prediction in Fe, Cr, and Ni are given in section 4. In addition, section4 includes estimates of damage generation rates for these materials in selected ATR irradiation locations. In section 5, the authors present a brief discussion of the most significant conclusions of this work and comment on its relevance to the present ATR core configuration. Finally, detailed numerical and graphical results for the spectrum-characterization analyses in each irradiation location are provided in the Appendix.

  7. Purchasing & supply management for a sustainable world: Introduction to the IPSERA 2013 conference special issue

    DEFF Research Database (Denmark)

    Johnsen, T. E.; Giannakis, M.; Miemczyk, J.

    2014-01-01

    Special issue of best papers of the 22nd annual IPSERA conference 2013: Purchasing & Supply Management for a Sustainable World......Special issue of best papers of the 22nd annual IPSERA conference 2013: Purchasing & Supply Management for a Sustainable World...

  8. The Second UNESCO World Conference on Arts Education

    Science.gov (United States)

    Buck, Ralph

    2010-01-01

    This article reports on the second UNESCO World Conference on Arts and Education held on May 25-28, 2010 in Seoul, Korea, which brought together approximately 650 arts educators from 95 UNESCO member states (countries) for a four-day summit of international diplomacy, cross-arts networking, global and regional strategic planning and professional…

  9. Proceedings of the fourth international conference and exhibition: World Congress on superconductivity. Volume 2

    Energy Technology Data Exchange (ETDEWEB)

    Krishen, K.; Burnham, C. [eds.] [National Aeronautics and Space Administration, Houston, TX (United States). Lyndon B. Johnson Space Center

    1994-12-31

    This document contains papers presented at the 4th International Conference Exhibition: World Congress on Superconductivity held at the Marriott Orlando World Center, Orlando, Florida, June 27--July 1, 1994. This conference encompassed research, technology, applications, funding, political, and social aspects of superconductivity. Specifically, the areas of research, technology, and development covered during the conference included high-temperature materials, thin films, C-60 based superconductors, persistent magnetic fields and shielding, fabrication methodology, space applications, physical applications, performance characterization, device applications, weak link effects and flux motion, accelerator technology, superconductivity energy, storage, future research and development directions, medical applications, granular superconductors, wire fabrication technology, computer applications, technical and commercial challenges, and power and energy applications. The key objective of this conference was to provide a forum for the world community to share technological results of recent advances made in the field of superconductivity and to discuss translation of the research to technology which will benefit humanity. More than 150 presentations were made at this conference. Individual papers are indexed separately on the Energy Data Bases.

  10. Proceedings of the fourth international conference and exhibition: World Congress on superconductivity. Volume 2

    International Nuclear Information System (INIS)

    Krishen, K.; Burnham, C.

    1994-01-01

    This document contains papers presented at the 4th International Conference Exhibition: World Congress on Superconductivity held at the Marriott Orlando World Center, Orlando, Florida, June 27--July 1, 1994. This conference encompassed research, technology, applications, funding, political, and social aspects of superconductivity. Specifically, the areas of research, technology, and development covered during the conference included high-temperature materials, thin films, C-60 based superconductors, persistent magnetic fields and shielding, fabrication methodology, space applications, physical applications, performance characterization, device applications, weak link effects and flux motion, accelerator technology, superconductivity energy, storage, future research and development directions, medical applications, granular superconductors, wire fabrication technology, computer applications, technical and commercial challenges, and power and energy applications. The key objective of this conference was to provide a forum for the world community to share technological results of recent advances made in the field of superconductivity and to discuss translation of the research to technology which will benefit humanity. More than 150 presentations were made at this conference. Individual papers are indexed separately on the Energy Data Bases

  11. Thoughts on the World Conference on Women. A Chinese woman writes.

    Science.gov (United States)

    Chuan, R

    1995-01-01

    Increasing social consciousness about human rights issues in China has, in turn, stimulated Chinese women's awareness of their individual rights. The Chinese government, however, has maintained tight control over the dissemination of feminist ideas and restricted media coverage of the Fourth World Conference on Women, held in Beijing in 1995. To discredit feminism, Chinese officials link it with sexual liberation, single motherhood, and lesbianism. Nonetheless, there is a new awareness that government statistics on the high rates of female employment conceal the reality that Chinese women are concentrated in low-paying, low-status occupations. In contrast to official propaganda, a United Nations Development Report ranked China 23rd in the world for women's participation in politics and the economy. In the course of preparing for the World Conference, a few nonofficial, grass-roots Chinese women's organizations were able to present their ideas.

  12. Proceedings of the 4. World TRIGA Users Conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-10-29

    This document gathers 30 presentations given at the 2008 Conference of the World TRIGA reactor Users. Most presentations are in the form of slides only, and few ones have an additional summary or are presented as an article only. All aspects of TRIGA-type reactors are approached, from upgrading to decommissioning, from radiotherapy to isotope production, from research program management to training, etc.

  13. Proceedings of the 4. World TRIGA Users Conference

    International Nuclear Information System (INIS)

    2008-01-01

    This document gathers 30 presentations given at the 2008 Conference of the World TRIGA reactor Users. Most presentations are in the form of slides only, and few ones have an additional summary or are presented as an article only. All aspects of TRIGA-type reactors are approached, from upgrading to decommissioning, from radiotherapy to isotope production, from research program management to training, etc

  14. IDRC at the World Conference of Science Journalists 2017 | IDRC ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2017-12-13

    Dec 13, 2017 ... IDRC at the World Conference of Science Journalists 2017 ... “Bridging Science and Societies”, the theme of WCSJ2017, reflects the vital role of science journalists and ... Using digital tech to improve life for refugees.

  15. 2017 World Conference on Information Systems and Technologies

    CERN Document Server

    Correia, Ana; Adeli, Hojjat; Reis, Luís; Costanzo, Sandra

    2017-01-01

    This book presents a selection of papers from the 2017 World Conference on Information Systems and Technologies (WorldCIST'17), held between the 11st and 13th of April 2017 at Porto Santo Island, Madeira, Portugal. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges involved in modern Information Systems and Technologies research, together with technological developments and applications. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Software and Systems Modeling; Software Systems, Architectures, Applications and Tools; Multimedia Systems and Applications; Computer Networks, Mobility and Pervasive Systems; Intelligent and Decision Support Systems; Big Data Analytics and Applications; Human–Computer Interaction; Ethics, Computers & Security; Health Informatics; Information Technologies in Education; and Information Tec...

  16. 2016 World Conference on Information Systems and Technologies

    CERN Document Server

    Correia, Ana; Adeli, Hojjat; Reis, Luis; Teixeira, Marcelo

    2016-01-01

    This book contains a selection of articles from The 2016 World Conference on Information Systems and Technologies (WorldCIST'16), held between the 22nd and 24th of March at Recife, Pernambuco, Brazil. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges of modern Information Systems and Technologies research, together with their technological development and applications. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Software and Systems Modeling; Software Systems, Architectures, Applications and Tools; Multimedia Systems and Applications; Computer Networks, Mobility and Pervasive Systems; Intelligent and Decision Support Systems; Big Data Analytics and Applications; Human-Computer Interaction; Health Informatics; Information Technologies in Education; Information Technologies in Radiocommunications.

  17. Proceedings of the CERI 2001 World Oil Conference. CD ed.

    International Nuclear Information System (INIS)

    2001-01-01

    The integration and expansion of world oil markets was the main topic of this conference which featured 23 presentations dealing with developments in the international energy sector. The conference was divided into 8 sessions entitled: (1) oil prices, (2) oil and politics, (3) global oil supply, (4) North American supply and markets, (5) global oil demand, (6) oil.com, (7) the business of the environment, and (8) oil and money. The outlook of world energy markets was reviewed with particular emphasis on prospects for oil supply and reserves. The current status of the petroleum industry in both OPEC and non-OPEC oil exporting countries was discussed with reference to exploration, production, reserves, and hydrocarbon potential. The environmental, and socio-economic challenges that both the upstream and downstream industry will face challenges in the next century were also described. refs., tabs., figs

  18. 2014 World Conference on Information Systems and Technologies

    CERN Document Server

    Correia, Ana; Tan, Felix; Stroetmann, Karl

    2014-01-01

    This book contains a selection of articles from The 2014 World Conference on Information Systems and Technologies (WorldCIST'14), held between the 15th and 18th of April in Funchal, Madeira, Portugal, a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges of modern Information Systems and Technologies research, technological development and applications. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Intelligent and Decision Support Systems; Software Systems, Architectures, Applications and Tools; Computer Networks, Mobility and Pervasive Systems; Radar Technologies; Human-Computer Interaction; Health Informatics; and Information Technologies in Education.

  19. Towards a greener world : hydrogen and fuel cells 2004 conference and trade show. Conference proceedings

    International Nuclear Information System (INIS)

    2004-01-01

    Fuel Cells Canada and the Canadian Hydrogen Association hosted the Hydrogen and Fuel Cells 2004 Conference and Tradeshow in Toronto, Ontario, Canada on September 25-28, 2004. Industry leaders from around the world showcased the latest developments in fuel cell and hydrogen technology, and shared research breakthroughs. The conference focussed on many aspects of hydrogen and fuel cell technology, specifically: hydrogen technology progress, including storage, infrastructure and production; fuel cells, including quality, cost and applications; economics and policy, including government and industry strategies; fuel cell demonstrations, including transportation, micro-fuel cells, and portable power; and, impact on climate change, including health and the Kyoto Accord

  20. Cytoplasmic ATR Activation Promotes Vaccinia Virus Genome Replication

    Directory of Open Access Journals (Sweden)

    Antonio Postigo

    2017-05-01

    Full Text Available In contrast to most DNA viruses, poxviruses replicate their genomes in the cytoplasm without host involvement. We find that vaccinia virus induces cytoplasmic activation of ATR early during infection, before genome uncoating, which is unexpected because ATR plays a fundamental nuclear role in maintaining host genome integrity. ATR, RPA, INTS7, and Chk1 are recruited to cytoplasmic DNA viral factories, suggesting canonical ATR pathway activation. Consistent with this, pharmacological and RNAi-mediated inhibition of canonical ATR signaling suppresses genome replication. RPA and the sliding clamp PCNA interact with the viral polymerase E9 and are required for DNA replication. Moreover, the ATR activator TOPBP1 promotes genome replication and associates with the viral replisome component H5. Our study suggests that, in contrast to long-held beliefs, vaccinia recruits conserved components of the eukaryote DNA replication and repair machinery to amplify its genome in the host cytoplasm.

  1. Proceedings of the CERI 2002 World Oil Conference : Reading the Future. CD ed.

    International Nuclear Information System (INIS)

    2002-01-01

    The integration and expansion of world oil markets was the main topic of this conference which featured 18 presentations dealing with developments in the international energy sector. The conference provided an opportunity for participants to discuss issues regarding oil supply and demand, oil prices, OPEC's spare capacity, OPEC's view regarding increasing competition from Canada's oil sands, and what role non-conventional oil plays in today's marketplace. The conference was divided into 6 sessions entitled: (1) oil prices, business as usual, (2) world oil demand, the incredible shrinking market, (3) global oil supplies, (4) going offshore, (5) the politics of oil, and (6) the growing North American supply. The outlook of world energy markets was reviewed with particular emphasis on prospects for oil supply and reserves. Also, the current status of the petroleum industry in both OPEC and non-OPEC oil exporting countries was discussed with reference to exploration, production, reserves, and hydrocarbon potential as well as the environmental, and socio-economic challenges that the industry must face. refs., tabs., figs

  2. 2015 World Conference on Information Systems and Technologies

    CERN Document Server

    Correia, Ana; Costanzo, Sandor; Reis, Luis

    2015-01-01

    This book contains a selection of articles from The 2015 World Conference on Information Systems and Technologies (WorldCIST'15), held between the 1st and 3rd of April in Funchal, Madeira, Portugal, a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences and challenges of modern Information Systems and Technologies research, technological development and applications. The main topics covered are: Information and Knowledge Management; Organizational Models and Information Systems; Intelligent and Decision Support Systems; Big Data Analytics and Applications; Software Systems, Architectures, Applications and Tools; Multimedia Systems and Applications; Computer Networks, Mobility and Pervasive Systems; Human-Computer Interaction; Health Informatics; Information Technologies in Education; Information Technologies in Radiocommunications.

  3. Doha, Warsaw, transition conferences towards a world agreement on climate in 2015?

    International Nuclear Information System (INIS)

    Auverlot, Dominique; Barreau, Blandine

    2013-10-01

    This note discusses the results of the last conference on climate held in Doha in 2012: beginning of a second period for the Kyoto protocol commitment, a first reflection on a future world agreement, on-going but still unsuccessful debates on international solidarity, increasing importance of the issue of 'loss and damage' in the negotiation. It also discusses the pathway toward a new world agreement: risk of a divided and isolated Europe, taking the requirement of equity by developing countries into account, China and the USA at the centre of negotiations, recurrent decision difficulties within the Climate Convention. Within the perspective of the next Conference which will be held in Le Bourget, in 2015, this note addresses the strategic orientations: setting conditions of a successful debate in 2015 by using lessons learned from previous Conference of Parties, necessity of a united Europe, adoption of a proactive diplomacy by the EU relying on developing countries

  4. Safety significance of ATR passive safety response attributes

    International Nuclear Information System (INIS)

    Atkinson, S.A.

    1990-01-01

    The Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory was designed with some passive safety response attributes which contribute to the safety of the facility. The three passive safety attributes being evaluated in the paper are: 1) In-core and in-vessel natural convection cooling, 2) a passive heat sink capability of the ATR primary coolant system (PCS) for the transfer of decay power from the uninsulated piping to the confinement, and 3) gravity feed of emergency coolant makeup. The safety significance of the ATR passive safety response attributes is that the reactor can passively respond to most transients, given a reactor scram, to provide adequate decay power removal and a significant time for operator action should the normal active heat removal systems and their backup systems both fail. The ATR Interim Level 1 Probabilistic Risk Assessment (PRA) models and results were used to evaluate the significance to ATR fuel damage frequency (or probability) of the above three passive response attributes. The results of the evaluation indicate that the first attribute is a major safety characteristic of the ATR. The second attribute has a noticeable but only minor safety significance. The third attribute has no significant influence on the ATR firewater injection system (emergency coolant system)

  5. Detroit, 22-27 September 1974: Report on ninth world energy conference

    International Nuclear Information System (INIS)

    1974-01-01

    The acceleration of world demand for energy during the last forty years has led to a projection of future needs far in excess of present capacity, and one which threatens exhaustion of today's conventional sources at some future time. Coupled with this premise is the realization of two inter-related facts: inadequate, uneconomic sources of energy cripple a man, his nation, and his world and lead to insecurity, famine and ignorance; on the other hand, excessive, uncontrolled use of energy sources leads to wastage of resources, pollution and human misery that likewise respects no national boundaries. These dominating concerns led to the selection of the main theme of the Ninth World Energy Conference - 'The Economic and Environmental Challenges of Future Energy Requirements'. This theme was broadly broken down into six main categories: energy needs, sources of energy, energy conversion and utilization, conservation of energy, economics and environmental considerations. A total of 229 formal papers were considered by the several thousand participants who represented more than 60 countries and a number of international organizations at the Conference

  6. Detroit, 22-27 September 1974: Report on ninth world energy conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1974-07-01

    The acceleration of world demand for energy during the last forty years has led to a projection of future needs far in excess of present capacity, and one which threatens exhaustion of today's conventional sources at some future time. Coupled with this premise is the realization of two inter-related facts: inadequate, uneconomic sources of energy cripple a man, his nation, and his world and lead to insecurity, famine and ignorance; on the other hand, excessive, uncontrolled use of energy sources leads to wastage of resources, pollution and human misery that likewise respects no national boundaries. These dominating concerns led to the selection of the main theme of the Ninth World Energy Conference - 'The Economic and Environmental Challenges of Future Energy Requirements'. This theme was broadly broken down into six main categories: energy needs, sources of energy, energy conversion and utilization, conservation of energy, economics and environmental considerations. A total of 229 formal papers were considered by the several thousand participants who represented more than 60 countries and a number of international organizations at the Conference.

  7. ATR-dependent bystander effects in non-targeted cells

    International Nuclear Information System (INIS)

    Burdak-Rothkamm, S.

    2007-01-01

    Complete text of publication follows. Radiation induced non-targeted bystander effects have been reported for a range of endpoints including the induction of γH2AX foci which serve as a marker for DNA double strand breaks. We have recently reported the induction of γH2AX foci in non-targeted bystander cells up to 48 hours after irradiation and the involvement of reactive oxygen species (ROS) and TGF-beta 1 in the induction of γH2AX foci (Oncogene (2007) 26:993-1002). Here, we wanted to determine the role of the PI3-like kinases ATM, ATR and DNA-PK in DNA damage signalling in bystander cells. Conditioned medium from T98G cells irradiated with 2 Gy of X-rays was transferred onto non-irradiated cells that were subsequently analysed for the induction of γH2AX, ATR and 53BP1 foci as well as clonogenic survival. Irradiated T98G glioma cells generated signals that induced γH2AX and 53BP1 foci in cells treated with the conditioned medium from irradiated cells. These foci co-localised with ATR foci. Inhibition of ATM and DNA-PK could not suppress the induction of bystander γH2AX foci whereas the mutation of ATR in Seckel cells abrogated bystander foci induction. A restriction of bystander foci to the S-phase of the cell cycle both in T98G cells and in ATR- proficient fibroblasts was observed. These results identify ATR as a central player within the bystander signalling cascade leading to γH2AX and 53BP1 foci formation, and suggest a mechanism of DNA damage induction in non-targeted cells. Further investigations have shown decreased clonogenic cell survival in bystander T98G and ATR wild-type fibroblasts. ATR mutated Seckel cells and also ATM-/- fibroblasts were resistant to this effect suggesting a role for both ATR and ATM in the bystander signalling cascade with regard to cell survival. Taken together, these observations support a hypothesis of DNA damage-induced accumulation of stalled replication forks in bystander cells which are subsequently processed by

  8. Focusing and matching properties of the ATR transfer line

    International Nuclear Information System (INIS)

    Tsoupas, N.; Fischer, W.; Kewisch, J.; MacKay, W.W.; Peggs, S.; Pilat, F.; Tepikian, S.; Wei, J.

    1997-01-01

    The AGS to RHIC (AtR) beam transfer line has been constructed and will be used to transfer beam bunches from the AGS machine into the RHIC machine which is presently under construction at BNL. The original design of the AtR line has been modified. This article will present the optics of the various sections of the existing AtR beam line, as well as the matching capabilities of the AtR line to the RHIC machine

  9. ATR Spent Fuel Options Study

    International Nuclear Information System (INIS)

    Connolly, Michael James; Bean, Thomas E.; Brower, Jeffrey O.; Luke, Dale E.; Patterson, M. W.; Robb, Alan K.; Sindelar, Robert; Smith, Rebecca E.; Tonc, Vincent F.; Tripp, Julia L.; Winston, Philip L.

    2017-01-01

    The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage, and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center's (INTEC's) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing

  10. ATR Spent Fuel Options Study

    Energy Technology Data Exchange (ETDEWEB)

    Connolly, Michael James [Idaho National Lab. (INL), Idaho Falls, ID (United States); Bean, Thomas E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Brower, Jeffrey O. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Luke, Dale E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Patterson, M. W. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Robb, Alan K. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sindelar, Robert [Idaho National Lab. (INL), Idaho Falls, ID (United States); Smith, Rebecca E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tonc, Vincent F. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Tripp, Julia L. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Winston, Philip L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-01

    The Advanced Test Reactor (ATR) is a materials and fuels test nuclear reactor that performs irradiation services for the U.S. Department of Energy (DOE) Office of Nuclear Energy (NE), Naval Reactors, the National Nuclear Security Administration (NNSA), and other research programs. ATR achieved initial criticality in 1967 and is expected to operate in support of needed missions until the year 2050 or beyond. It is anticipated that ATR will generate approximately 105 spent nuclear fuel (SNF) elements per year through the year 2050. Idaho National Laboratory (INL) currently stores 2,008 ATR SNF elements in dry storage, 976 in wet storage, and expects to have 1,000 elements in wet storage before January 2017. A capability gap exists at INL for long-term (greater than the year 2050) management, in compliance with the Idaho Settlement Agreement (ISA), of ATR SNF until a monitored retrievable geological repository is open. INL has significant wet and dry storage capabilities that are owned by the DOE Office of Environmental Management (EM) and operated and managed by Fluor Idaho, which include the Idaho Nuclear Technology and Engineering Center’s (INTEC’s) CPP-666, CPP-749, and CPP-603. In addition, INL has other capabilities owned by DOE-NE and operated and managed by Battelle Energy Alliance, LLC (BEA), which are located at the Materials and Fuel Complex (MFC). Additional storage capabilities are located on the INL Site at the Naval Reactors Facility (NRF). Current INL SNF management planning, as defined in the Fluor Idaho contract, shows INTEC dry fuel storage, which is currently used for ATR SNF, will be nearly full after transfer of an additional 1,000 ATR SNF from wet storage. DOE-NE tasked BEA with identifying and analyzing options that have the potential to fulfill this capability gap. BEA assembled a team comprised of SNF management experts from Fluor Idaho, Savannah River Site (SRS), INL/BEA, and the MITRE Corp with an objective of developing and analyzing

  11. FLUX SENSOR EVALUATIONS AT THE ATR CRITICAL FACILITY

    International Nuclear Information System (INIS)

    Unruh, Troy; Rempe, Joy; Nigg, David; Imel, George; Harris, Jason; Bonebrake, Eric

    2010-01-01

    The Advanced Test Reactor (ATR) and the ATR Critical (ATRC) facilities lack real-time methods for detecting thermal neutron flux and fission reaction rates for irradiation capsules. Direct measurements of the actual power deposited into a test are now possible without resorting to complicated correction factors. In addition, it is possible to directly measure minor actinide fission reaction rates and to provide time-dependent monitoring of the fission reaction rate or fast/thermal flux during transient testing. A joint Idaho State University/Idaho National Laboratory ATR National Scientific User Facility (ATR NSUF) project was recently initiated to evaluate new real-time state-of-the-art in-pile flux detection sensors. Initially, the project is comparing the accuracy, response time, and long duration performance of French Atomic Energy Commission (CEA)-developed miniature fission chambers, specialized self-powered neutron detectors (SPNDs) by the Argentinean National Energy Commission (CNEA), specially developed commercial SPNDs, and back-to-back fission (BTB) chambers developed by Argonne National Laboratory (ANL). As discussed in this paper, specialized fixturing and software was developed by INL to facilitate these joint ISU/INL evaluations. Calculations were performed by ISU to assess the performance of and reduce uncertainties in flux detection sensors and compare data obtained from these sensors with existing integral methods employed at the ATRC. Ultimately, project results will be used to select the detector that can provide the best online regional ATRC power measurement. It is anticipated that project results may offer the potential to increase the ATRC's current power limit and its ability to perform low-level irradiation experiments. In addition, results from this effort will provide insights about the viability of using these detectors in the ATR. Hence, this effort complements current activities to improve ATR software tools, computational protocols

  12. ATR prohibits replication catastrophe by preventing global exhaustion of RPA.

    Science.gov (United States)

    Toledo, Luis Ignacio; Altmeyer, Matthias; Rask, Maj-Britt; Lukas, Claudia; Larsen, Dorthe Helena; Povlsen, Lou Klitgaard; Bekker-Jensen, Simon; Mailand, Niels; Bartek, Jiri; Lukas, Jiri

    2013-11-21

    ATR, activated by replication stress, protects replication forks locally and suppresses origin firing globally. Here, we show that these functions of ATR are mechanistically coupled. Although initially stable, stalled forks in ATR-deficient cells undergo nucleus-wide breakage after unscheduled origin firing generates an excess of single-stranded DNA that exhausts the nuclear pool of RPA. Partial reduction of RPA accelerated fork breakage, and forced elevation of RPA was sufficient to delay such "replication catastrophe" even in the absence of ATR activity. Conversely, unscheduled origin firing induced breakage of stalled forks even in cells with active ATR. Thus, ATR-mediated suppression of dormant origins shields active forks against irreversible breakage via preventing exhaustion of nuclear RPA. This study elucidates how replicating genomes avoid destabilizing DNA damage. Because cancer cells commonly feature intrinsically high replication stress, this study also provides a molecular rationale for their hypersensitivity to ATR inhibitors. Copyright © 2013 Elsevier Inc. All rights reserved.

  13. Population policy at a crossroads. Will world conference signal new directions for U.S.?

    Science.gov (United States)

    Mccarty, L; Sherman, D

    1994-06-01

    In September 1994 in Cairo, at the third population conference hosted by the United Nations, world leaders will be asked to approve a plan that could stabilize the world population at about 8 billion people by the middle of the next century. Participants will consider interrelated issues: population growth, access to family planning, women's empowerment, sustainable development, poverty, consumption, and the environment. This campaign for a more equitable world is likely to continue after Cairo, with the UN-sponsored social summit in Copenhagen and a women's conference in Beijing slated for next year. The Cairo International Conference on Population and Development will require a new approach to sustainability by balancing environmental protection, economic development, and present and future human needs. The United States has only 5% of the world's population, but it uses 25% of the world's commercial energy, produces more garbage and waste than any other country, and generates 21% of all carbon dioxide emissions, which contribute to global warming. Demands for energy, water and food already cannot be met as natural resources are being exhausted at an alarming rate. The fight over water rights to the Colorado River exemplifies the shrinking natural resource base. In contrast to the Reagan-Bush administration, the Clinton administration restored funding to international family planning agencies and endorsed sustainable development. The US birth rate is back at a 2-decade high, while 60% of pregnancies are unintended. US adolescent pregnancy is the highest among industrialized countries, leading to a cycle of poverty and soaring public costs. Government funding for new contraceptive research has been stagnant because of the pressure of right-wing groups, although finally RU-486 became available for clinical trials. The Cairo conference is likely to recognize the US as the leader in global political issues, however, domestic population and consumption issues have

  14. On techniques of ATR lattice computation

    International Nuclear Information System (INIS)

    1997-08-01

    Lattice computation is to compute the average nuclear constants of unit fuel lattice which are required for computing core nuclear characteristics such as core power distribution and reactivity characteristics. The main nuclear constants are infinite multiplying rate, neutron movement area, cross section for diffusion computation, local power distribution and isotope composition. As for the lattice computation code, WIMS-ATR is used, which is based on the WIMS-D code developed in U.K., and for the purpose of heightening the accuracy of analysis, which was improved by adding heavy water scattering cross section considering the temperature dependence by Honeck model. For the computation of the neutron absorption by control rods, LOIEL BLUE code is used. The extrapolation distance of neutron flux on control rod surfaces is computed by using THERMOS and DTF codes, and the lattice constants of adjoining lattices are computed by using the WIMS-ATR code. As for the WIMS-ATR code, the computation flow and nuclear data library, and as for the LOIEL BLUE code, the computation flow are explained. The local power distribution in fuel assemblies determined by the WIMS-ATR code was verified with the measured data, and the results are reported. (K.I.)

  15. 1st Complex Systems Digital Campus World E-Conference 2015

    CERN Document Server

    Bourgine, Paul; Collet, Pierre

    2017-01-01

    This book contains the proceedings as well as invited papers for the first annual conference of the UNESCO Unitwin Complex System Digital Campus (CSDC), which is an international initiative gathering 120 Universities on four continents, and structured in ten E-Departments. First Complex Systems Digital Campus World E-Conference 2015 features chapters from the latest research results on theoretical questions of complex systems and their experimental domains. The content contained bridges the gap between the individual and the collective within complex systems science and new integrative sciences on topics such as: genes to organisms to ecosystems, atoms to materials to products, and digital media to the Internet. The conference breaks new ground through a dedicated video-conferencing system – a concept at the heart of the international UNESCO UniTwin, embracing scientists from low-income and distant countries. This book promotes an integrated system of research, education, and training. It also aims at contr...

  16. ATR Commissioning Software Task Force Report

    Energy Technology Data Exchange (ETDEWEB)

    D' Ottavio, Ted [Brookhaven National Lab. (BNL), Upton, NY (United States); Kewisch, Jorg [Brookhaven National Lab. (BNL), Upton, NY (United States); Saltmarsh, Chris [Brookhaven National Lab. (BNL), Upton, NY (United States); Sathe, Smita [Brookhaven National Lab. (BNL), Upton, NY (United States); Satogata, Todd [Brookhaven National Lab. (BNL), Upton, NY (United States); Shea, Don [Brookhaven National Lab. (BNL), Upton, NY (United States); Tepikian, Steve [Brookhaven National Lab. (BNL), Upton, NY (United States); Trahern, Garry [Brookhaven National Lab. (BNL), Upton, NY (United States)

    1994-12-16

    The Beam Injection Tests Software Task Force was charged with studying the software needed for the ATR tests, seen as a stepping stone or template for the larger scope of the full RHIC control system. This report outlines our avenues of exploration so far, presents the current analysis and implementation work in progress, and gives recommendations for the future on the ATR and longer time scales.

  17. ATR confinement leakage determination

    International Nuclear Information System (INIS)

    Kuan, P.; Buescher, B.J.

    1998-01-01

    The air leakage rate from the Advanced Test Reactor (ATR) confinement is an important parameter in estimating hypothesized accidental releases of radiation to the environment. The leakage rate must be determined periodically to assure that the confinement has not degraded with time and such determination is one of the technical safety requirements of ATR operation. This paper reviews the methods of confinement leakage determination and presents an analysis of leakage determination under windy conditions, which can complicate the interpretation of the determined leakage rates. The paper also presents results of analyses of building air exchange under windy conditions. High wind can enhance air exchange and this could increase the release rates of radioisotopes following an accident

  18. Atlantic Test Range (ATR)

    Data.gov (United States)

    Federal Laboratory Consortium — ATR controls fully-instrumented and integrated test ranges that provide full-service support for cradle-to-grave testing. Airspace and surface target areas are used...

  19. A mitosis-specific and R loop-driven ATR pathway promotes faithful chromosome segregation.

    Science.gov (United States)

    Kabeche, Lilian; Nguyen, Hai Dang; Buisson, Rémi; Zou, Lee

    2018-01-05

    The ataxia telangiectasia mutated and Rad3-related (ATR) kinase is crucial for DNA damage and replication stress responses. Here, we describe an unexpected role of ATR in mitosis. Acute inhibition or degradation of ATR in mitosis induces whole-chromosome missegregation. The effect of ATR ablation is not due to altered cyclin-dependent kinase 1 (CDK1) activity, DNA damage responses, or unscheduled DNA synthesis but to loss of an ATR function at centromeres. In mitosis, ATR localizes to centromeres through Aurora A-regulated association with centromere protein F (CENP-F), allowing ATR to engage replication protein A (RPA)-coated centromeric R loops. As ATR is activated at centromeres, it stimulates Aurora B through Chk1, preventing formation of lagging chromosomes. Thus, a mitosis-specific and R loop-driven ATR pathway acts at centromeres to promote faithful chromosome segregation, revealing functions of R loops and ATR in suppressing chromosome instability. Copyright © 2018, American Association for the Advancement of Science.

  20. Proceedings of the CERI 2003 World Oil Conference : What lies beneath? CD-ROM ed.

    International Nuclear Information System (INIS)

    2003-01-01

    The 22 presentations at this conference reflected recent developments in the international petroleum industry with particular focus on the outlook of world energy markets and prospects for oil supply and reserves. Topics of discussion included the industry structure, development and operating costs, international spending, the expansion of world oil markets, market access, as well as new technology development and application. The papers also covered environmental issues such as climate change and the responsible use of water. The conference provided an opportunity for participants to discuss issues regarding oil supply and demand, oil prices, Canada's oil sands, and what role non-conventional oil plays in the current marketplace. The conference was divided into 7 sessions entitled: (1) outlook for oil prices, (2) global oil supplies, (3) oil and money, (4) downstream issues, (5) markets for Canadian bitumen and synthetics, (6) Canada's east coast, and (7) the geopolitical landscape. Three papers were indexed separately for inclusion in the database. tabs., figs

  1. Multivariate analysis of ATR-FTIR spectra for assessment of oil shale organic geochemical properties

    Science.gov (United States)

    Washburn, Kathryn E.; Birdwell, Justin E.

    2013-01-01

    In this study, attenuated total reflectance (ATR) Fourier transform infrared spectroscopy (FTIR) was coupled with partial least squares regression (PLSR) analysis to relate spectral data to parameters from total organic carbon (TOC) analysis and programmed pyrolysis to assess the feasibility of developing predictive models to estimate important organic geochemical parameters. The advantage of ATR-FTIR over traditional analytical methods is that source rocks can be analyzed in the laboratory or field in seconds, facilitating more rapid and thorough screening than would be possible using other tools. ATR-FTIR spectra, TOC concentrations and Rock–Eval parameters were measured for a set of oil shales from deposits around the world and several pyrolyzed oil shale samples. PLSR models were developed to predict the measured geochemical parameters from infrared spectra. Application of the resulting models to a set of test spectra excluded from the training set generated accurate predictions of TOC and most Rock–Eval parameters. The critical region of the infrared spectrum for assessing S1, S2, Hydrogen Index and TOC consisted of aliphatic organic moieties (2800–3000 cm−1) and the models generated a better correlation with measured values of TOC and S2 than did integrated aliphatic peak areas. The results suggest that combining ATR-FTIR with PLSR is a reliable approach for estimating useful geochemical parameters of oil shales that is faster and requires less sample preparation than current screening methods.

  2. Proceedings of the 11th World Conference on Mobile and Contextual Learning

    OpenAIRE

    Specht, Marcus; Sharples, Mike; Multisilta, Jari

    2013-01-01

    Specht, M., Sharples, M., & Multisilta, J. (Eds.) (2012). Proceedings of the 11th World Conference on Mobile and Contextual Learning (mLearn 2012). October, 16-18, 2012, Helsinki, Finland. Published by CEUR Workshop Proceedings, 2012, Vol. 995. Retrieved from http://ceur-ws.org/Vol-955/

  3. Safety significance of ATR [Advanced Test Reactor] passive safety response attributes

    International Nuclear Information System (INIS)

    Atkinson, S.A.

    1989-01-01

    The Advanced Test Reactor (ATR) at the Idaho National Engineering Laboratory was designed with some passive safety response attributes which contribute to the safety posture of the facility. The three passive safety attributes being evaluated in the paper are: (1) In-core and in-vessel natural convection cooling, (2) a passive heat sink capability of the ATR primary coolant system (PCS) for the transfer of decay power from the uninsulated piping to the confinement, and (3) gravity feed of emergency coolant makeup. The safety significance of the ATR passive safety response attributes is that the reactor can passively respond for most transients, given a reactor scram, to provide adequate decay power removal and a significant time for operator action should the normal active heat removal systems and their backup systems both fail. The ATR Interim Level 1 Probabilistic Risk Assessment (PRA) model ands results were used to evaluate the significance to ATR fuel damage frequency (or probability) of the above three passive response attributes. The results of the evaluation indicate that the first attribute is a major safety characteristic of the ATR. The second attribute has a noticeable but only minor safety significance. The third attribute has no significant influence on the ATR Level 1 PRA because of the diversity and redundancy of the ATR firewater injection system (emergency coolant system). 8 refs., 4 figs., 1 tab

  4. Activation of the ATR kinase by the RPA-binding protein ETAA1

    DEFF Research Database (Denmark)

    Haahr, Peter; Hoffmann, Saskia; Tollenaere, Maxim A X

    2016-01-01

    Activation of the ATR kinase following perturbations to DNA replication relies on a complex mechanism involving ATR recruitment to RPA-coated single-stranded DNA via its binding partner ATRIP and stimulation of ATR kinase activity by TopBP1. Here, we discovered an independent ATR activation pathway...... in vertebrates, mediated by the uncharacterized protein ETAA1 (Ewing's tumour-associated antigen 1). Human ETAA1 accumulates at DNA damage sites via dual RPA-binding motifs and promotes replication fork progression and integrity, ATR signalling and cell survival after genotoxic insults. Mechanistically...

  5. Assessment of COTS IR image simulation tools for ATR development

    Science.gov (United States)

    Seidel, Heiko; Stahl, Christoph; Bjerkeli, Frode; Skaaren-Fystro, Paal

    2005-05-01

    Following the tendency of increased use of imaging sensors in military aircraft, future fighter pilots will need onboard artificial intelligence e.g. ATR for aiding them in image interpretation and target designation. The European Aeronautic Defence and Space Company (EADS) in Germany has developed an advanced method for automatic target recognition (ATR) which is based on adaptive neural networks. This ATR method can assist the crew of military aircraft like the Eurofighter in sensor image monitoring and thereby reduce the workload in the cockpit and increase the mission efficiency. The EADS ATR approach can be adapted for imagery of visual, infrared and SAR sensors because of the training-based classifiers of the ATR method. For the optimal adaptation of these classifiers they have to be trained with appropriate and sufficient image data. The training images must show the target objects from different aspect angles, ranges, environmental conditions, etc. Incomplete training sets lead to a degradation of classifier performance. Additionally, ground truth information i.e. scenario conditions like class type and position of targets is necessary for the optimal adaptation of the ATR method. In Summer 2003, EADS started a cooperation with Kongsberg Defence & Aerospace (KDA) from Norway. The EADS/KDA approach is to provide additional image data sets for training-based ATR through IR image simulation. The joint study aims to investigate the benefits of enhancing incomplete training sets for classifier adaptation by simulated synthetic imagery. EADS/KDA identified the requirements of a commercial-off-the-shelf IR simulation tool capable of delivering appropriate synthetic imagery for ATR development. A market study of available IR simulation tools and suppliers was performed. After that the most promising tool was benchmarked according to several criteria e.g. thermal emission model, sensor model, targets model, non-radiometric image features etc., resulting in a

  6. Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila.

    Science.gov (United States)

    Park, Joung-Sun; Na, Hyun-Jin; Pyo, Jung-Hoon; Jeon, Ho-Jun; Kim, Young-Shin; Yoo, Mi-Ae

    2015-05-01

    The stem cell genomic stability forms the basis for robust tissue homeostasis, particularly in high-turnover tissues. For the genomic stability, DNA damage response (DDR) is essential. This study was focused on the role of two major DDR-related factors, ataxia telangiectasia-mutated (ATM) and ATM- and RAD3-related (ATR) kinases, in the maintenance of intestinal stem cells (ISCs) in the adultDrosophila midgut. We explored the role of ATM and ATR, utilizing immunostaining with an anti-pS/TQ antibody as an indicator of ATM/ATR activation, γ-irradiation as a DNA damage inducer, and the UAS/GAL4 system for cell type-specific knockdown of ATM, ATR, or both during adulthood. The results showed that the pS/TQ signals got stronger with age and after oxidative stress. The pS/TQ signals were found to be more dependent on ATR rather than on ATM in ISCs/enteroblasts (EBs). Furthermore, an ISC/EB-specific knockdown of ATR, ATM, or both decreased the number of ISCs and oxidative stress-induced ISC proliferation. The phenotypic changes that were caused by the ATR knockdown were more pronounced than those caused by the ATM knockdown; however, our data indicate that ATR and ATM are both needed for ISC maintenance and proliferation; ATR seems to play a bigger role than does ATM.

  7. Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.

    Science.gov (United States)

    Choi, Jun-Hyuk; Lindsey-Boltz, Laura A; Kemp, Michael; Mason, Aaron C; Wold, Marc S; Sancar, Aziz

    2010-08-03

    ATR kinase is a critical upstream regulator of the checkpoint response to various forms of DNA damage. Previous studies have shown that ATR is recruited via its binding partner ATR-interacting protein (ATRIP) to replication protein A (RPA)-covered single-stranded DNA (RPA-ssDNA) generated at sites of DNA damage where ATR is then activated by TopBP1 to phosphorylate downstream targets including the Chk1 signal transducing kinase. However, this critical feature of the human ATR-initiated DNA damage checkpoint signaling has not been demonstrated in a defined system. Here we describe an in vitro checkpoint system in which RPA-ssDNA and TopBP1 are essential for phosphorylation of Chk1 by the purified ATR-ATRIP complex. Checkpoint defective RPA mutants fail to activate ATR kinase in this system, supporting the conclusion that this system is a faithful representation of the in vivo reaction. Interestingly, we find that an alternative form of RPA (aRPA), which does not support DNA replication, can substitute for the checkpoint function of RPA in vitro, thus revealing a potential role for aRPA in the activation of ATR kinase. We also find that TopBP1 is recruited to RPA-ssDNA in a manner dependent on ATRIP and that the N terminus of TopBP1 is required for efficient recruitment and activation of ATR kinase.

  8. MIR-ATR sensor for process monitoring

    International Nuclear Information System (INIS)

    Geörg, Daniel; Schalk, Robert; Beuermann, Thomas; Methner, Frank-Jürgen

    2015-01-01

    A mid-infrared attenuated total reflectance (MIR-ATR) sensor has been developed for chemical reaction monitoring. The optical setup of the compact and low-priced sensor consists of an IR emitter as light source, a zinc selenide (ZnSe) ATR prism as boundary to the process, and four thermopile detectors, each equipped with an optical bandpass filter. The practical applicability was tested during esterification of ethanol and formic acid to ethyl formate and water as a model reaction with subsequent distillation. For reference analysis, a Fourier transform mid-infrared (FT-MIR) spectrometer with diamond ATR module was applied. On-line measurements using the MIR-ATR sensor and the FT-MIR spectrometer were performed in a bypass loop. The sensor was calibrated by multiple linear regression in order to link the measured absorbance in the four optical channels to the analyte concentrations. The analytical potential of the MIR-ATR sensor was demonstrated by simultaneous real-time monitoring of all four chemical substances involved in the esterification and distillation process. The temporal courses of the sensor signals are in accordance with the concentration values achieved by the commercial FT-MIR spectrometer. The standard error of prediction for ethanol, formic acid, ethyl formate, and water were 0.38 mol L   −  1 , 0.48 mol L   −  1 , 0.38 mol L   −  1 , and 1.12 mol L   −  1 , respectively. A procedure based on MIR spectra is presented to simulate the response characteristics of the sensor if the transmission ranges of the filters are varied. Using this tool analyte specific bandpass filters for a particular chemical reaction can be identified. By exchanging the optical filters, the sensor can be adapted to a wide range of processes in the chemical, pharmaceutical, and beverage industries. (paper)

  9. Archimedes in the 21st Century : World Conference at the Courant Institute of Mathematical Sciences

    CERN Document Server

    2017-01-01

    This book is a collection of papers presented at the “Archimedes in the 21st Century” world conference, held at the Courant Institute of Mathematical Sciences in 2013. This conference focused on the enduring and continuing influence of Archimedes in our modern world, celebrating his centuries of influence on mathematics, science, and engineering.  Archimedes planted the seeds for a myriad of seminal ideas that would grow over the ages. Each chapter surveys the growth of one or more of these seeds, and the fruit that they continue to bear to this day. The conference speakers contributing to this book are actively involved in STEM fields whose origins trace back to Archimedes, many of whom have conducted and published research that extends Archimedes’ work into the 21st century. The speakers are not historians, so while historical context is provided, this book is uniquely focused on the works themselves as opposed to their history.   The breadth and depth of Archimedes’ influence will inspire, deligh...

  10. Charting the new world order: proceedings of the 15. CERI international oil and gas markets conference

    International Nuclear Information System (INIS)

    1996-10-01

    The 15th International Oil and Gas Markets Conference, organized by the Canadian Energy Research Institute (CERI) and held in Calgary, AB, provided a wide variety of opportunities for discussion of the global oil and gas market outlook, international oil and gas market strategies and corporate planning in the new world order, competition for investments, the re-emergence of the geopolitics of energy, energy in the Americas, international gas market strategies, and the financing of Canadian international operations. More than 100 delegates from around the world attended the conference to hear some 20 presentations. refs., tabs., figs

  11. Advance of core design method for ATR

    International Nuclear Information System (INIS)

    Maeda, Seiichirou; Ihara, Toshiteru; Iijima, Takashi; Seino, Hideaki; Kobayashi, Tetsurou; Takeuchi, Michio; Sugawara, Satoru; Matsumoto, Mitsuo.

    1995-01-01

    Core characteristics of ATR demonstration plant has been revised such as increasing the fuel burnup and the channel power, which is achieved by changing the number of fuel rod per fuel assembly from 28 to 36. The research and development concerning the core design method for ATR have been continued. The calculational errors of core analysis code have been evaluated using the operational data of FUGEN and the full scale simulated test results in DCA (Deuterium Critical Assembly) and HTL (Heat Transfer Loop) at O-arai engineering center. It is confirmed that the calculational error of power distribution is smaller than the design value of ATR demonstration plant. Critical heat flux correlation curve for 36 fuel rod cluster has been developed and the probability evaluation method based on its curve, which is more rational to evaluate the fuel dryout, has been adopted. (author)

  12. Grayscale optical correlator for real-time onboard ATR

    Science.gov (United States)

    Chao, Tien-Hsin; Zhou, Hanying; Reyes, George F.

    2001-03-01

    Jet Propulsion Laboratory has been developing grayscale optical correlator (GOC) for a variety of automatic target recognition (ATR) applications. As reported in previous papers, a 128 X 128 camcorder-sized GOC has been demonstrated for real-time field ATR demos. In this paper, we will report the recent development of a prototype 512 X 512 GOC utilizing a new miniature ferroelectric liquid crystal spatial light modulator with a 7-micrometers pixel pitch. Experimental demonstration of ATR applications using this new GOC will be presented. The potential of developing a matchbox-sized GOC will also be discussed. A new application of synthesizing new complex-valued correlation filters using this real-axis 512 X 512 SLM will also be included.

  13. 4th World Conference on Soft Computing

    CERN Document Server

    Abbasov, Ali; Yager, Ronald; Shahbazova, Shahnaz; Reformat, Marek

    2016-01-01

    This book reports on advanced theories and cutting-edge applications in the field of soft computing. The individual chapters, written by leading researchers, are based on contributions presented during the 4th World Conference on Soft Computing, held May 25-27, 2014, in Berkeley. The book covers a wealth of key topics in soft computing, focusing on both fundamental aspects and applications. The former include fuzzy mathematics, type-2 fuzzy sets, evolutionary-based optimization, aggregation and neural networks, while the latter include soft computing in data analysis, image processing, decision-making, classification, series prediction, economics, control, and modeling. By providing readers with a timely, authoritative view on the field, and by discussing thought-provoking developments and challenges, the book will foster new research directions in the diverse areas of soft computing. .

  14. Ph.D. Researchers in a Changing World: A Self-Critical Reflection of the CES Conference 2017

    Directory of Open Access Journals (Sweden)

    Alexander James Darracott

    2017-10-01

    Full Text Available The theme of this year’s Centre for Education Studies Interdisciplinary Postgraduate Conference, now in its fifth year, is 'Education in a Changing World'. I attended the conference as a paper presenter and a conference attendee. My personal goals were to develop confidence as an oral presenter, seek professional development opportunities, and engage critically and reflectively with my work and the work of others.  My relativist epistemological beliefs define knowledge as uncertain, context-bound, fallible, defeasible and therefore changeable, and are compatible with my personal goals. Both the goals and beliefs led to the adoption of knowledge co-constructor, communicator, and analyst roles.  Beliefs, goals and adopted roles led to the identification of points of fallibility in my own knowledge and understanding of the phenomenon of interest. Therefore, I formed a perspective of conferences as enabling and facilitating knowledge construction between presenter and audience. Being reflective, critical, adaptable, creative, intuitive, flexible, and open minded are key attitudinal attributes of postgraduates, leading to positive conference experiences and increased self-awareness of own emerging identity as a social scientist. Increasing self-awareness of own identity is important for graduates, as on a broader scale this assists in keeping pace with an ever-changing world.

  15. Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection

    DEFF Research Database (Denmark)

    Carson, Christian T; Orazio, Nicole I; Lee, Darwin V

    2009-01-01

    The protein kinases ataxia-telangiectasia mutated (ATM) and ATM-Rad3 related (ATR) are activated in response to DNA damage, genotoxic stress and virus infections. Here we show that during infection with wild-type adenovirus, ATR and its cofactors RPA32, ATRIP and TopBP1 accumulate at viral...... during virus infection, which is independent of Mre11 nuclease activity and recruitment of RPA/ATR/ATRIP/TopBP1. Unlike other damage scenarios, we found that ATM and ATR signaling are not dependent on each other during infection. We identify a region of the viral E4orf3 protein responsible...

  16. An ATR architecture for algorithm development and testing

    Science.gov (United States)

    Breivik, Gøril M.; Løkken, Kristin H.; Brattli, Alvin; Palm, Hans C.; Haavardsholm, Trym

    2013-05-01

    A research platform with four cameras in the infrared and visible spectral domains is under development at the Norwegian Defence Research Establishment (FFI). The platform will be mounted on a high-speed jet aircraft and will primarily be used for image acquisition and for development and test of automatic target recognition (ATR) algorithms. The sensors on board produce large amounts of data, the algorithms can be computationally intensive and the data processing is complex. This puts great demands on the system architecture; it has to run in real-time and at the same time be suitable for algorithm development. In this paper we present an architecture for ATR systems that is designed to be exible, generic and efficient. The architecture is module based so that certain parts, e.g. specific ATR algorithms, can be exchanged without affecting the rest of the system. The modules are generic and can be used in various ATR system configurations. A software framework in C++ that handles large data ows in non-linear pipelines is used for implementation. The framework exploits several levels of parallelism and lets the hardware processing capacity be fully utilised. The ATR system is under development and has reached a first level that can be used for segmentation algorithm development and testing. The implemented system consists of several modules, and although their content is still limited, the segmentation module includes two different segmentation algorithms that can be easily exchanged. We demonstrate the system by applying the two segmentation algorithms to infrared images from sea trial recordings.

  17. ATR, Radiation Transport Models in Atmosphere at Various Altitudes

    International Nuclear Information System (INIS)

    1981-01-01

    1 - Description of problem or function: ATR is a user-oriented code for calculating quickly and simply radiation environment problems at all altitudes in the atmosphere. The code is based on parametric models of a comprehensive data base of air transport results which were generated using discrete ordinates transport techniques for infinite homogeneous air. The effects of air-ground interface and non-uniform air density are treated as perturbation corrections on homogeneous air results. ATR includes parametric models for neutrons and secondary gamma rays as a function of space, energy and source- target angle out to angles of 550 g/cm 2 of air. ATR contains parameterizations of infinite medium air transport of neutrons and secondary gamma rays and correction factors for the air-ground interface and high altitude exponential air. It responds to a series of user-oriented commands which specify the source, geometry and print options to output a variety of useful air transport information, including energy-angle dependent fluence, dose, current, and isodose ranges. 2 - Method of solution: The version 3 differs from earlier versions in that version 3 contains the parameterization of the new neutron and secondary gamma rays data base that was calculated using the latest DNA approved cross sections for air. Other improvements to the ATR code include: parameterization and inclusion into ATR of new air- over-ground correction factors, low energy x-rays calculations, new fission source, and new convenience options. 3 - Restrictions on the complexity of the problem: ATR takes approximately 36,000 decimal words of storage. This can be lessened by overlaying different parts of the code

  18. [Twenty-second conference of the Czechoslovak Demographic Society: "The Demographic Position of Czechoslovakia within Europe and the World"].

    Science.gov (United States)

    Fialova, L; Rychtarikova, J; Roubicek, V; Stloukal, L; Veres, P; Koschin, F; Novakova, B; Pavlik, Z

    1992-01-01

    This is a collection of short papers presented at a conference held in Prague, Czechoslovakia, in 1991. The focus of the conference was on the demographic changes that have occurred in Czechoslovakia since World War II and their relationship to such changes in the rest of Europe and elsewhere in the world. Essay topics include fertility trends; contraceptive prevalence, including abortion rates; living standards and health care; and changes in the age structure. Some data for selected countries are included for comparison. (SUMMARY IN ENG AND RUS)

  19. Call for Nominations The Nusselt Reynolds Prize Sponsored by Assembly of World Conferences on Experimental Heat Transfer, Fluid Mechanics, and Thermodynamics

    Science.gov (United States)

    Kasagi, Nobuhide

    2000-01-01

    The Nusselt Reynolds Prize has been established by the Assembly of World Conferences to commemorate outstanding contributions by Wilhelm Nusselt and Osborne Reynolds as experimentalists, researchers, educators, and authors. As many as three prizes may be bestowed at every World Conference, one in each of the areas of heat transfer, fluid mechanics, thermodynamics, or any combination of these.

  20. Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma

    International Nuclear Information System (INIS)

    Beumer, Jan H.; Fu, Katherine Y.; Anyang, Bean N.; Siegfried, Jill M.; Bakkenist, Christopher J.

    2015-01-01

    ATM and ATR are kinases implicated in a myriad of DNA-damage responses. ATM kinase inhibition radiosensitizes cells and selectively kills cells with Fanconi anemia (FA) gene mutations. ATR kinase inhibition sensitizes cells to agents that induce replication stress and selectively kills cells with ATM and TP53 mutations. ATM mutations and FANCF promoter-methylation are reported in lung carcinomas. We undertook functional analyses of ATM, ATR, Chk1 and FA proteins in lung cancer cell lines. We included Calu6 that is reported to be FANCL-deficient. In addition, the cancer genome atlas (TCGA) database was interrogated for alterations in: 1) ATM, MRE11A, RAD50 and NBN; 2) ATR, ATRIP and TOPBP1; and 3) 15 FA genes. No defects in ATM, ATR or Chk1 kinase activation, or FANCD2 monoubiquitination were identified in the lung cancer cell lines examined, including Calu6, and major alterations in these pathways were not identified in the TCGA database. Cell lines were radiosensitized by ATM kinase inhibitor KU60019, but no cell killing by ATM kinase inhibitor alone was observed. While no synergy between gemcitabine or carboplatin and ATR kinase inhibitor ETP-46464 was observed, synergy between gemcitabine and Chk1 kinase inhibitor UCN-01 was observed in 54 T, 201 T and H460, and synergy between carboplatin and Chk1 kinase inhibitor was identified in 201 T and 239 T. No interactions between ATM, ATR and FA activation were observed by either ATM or ATR kinase inhibition in the lung cancer cell lines. Analyses of ATM serine 1981 and Chk1 serine 345 phosphorylation, and FANCD2 monoubiquitination revealed that ATM and ATR kinase activation and FA pathway signaling are intact in the lung cancer cell lines examined. As such, these posttranslational modifications may have utility as biomarkers for the integrity of DNA damage signaling pathways in lung cancer. Different sensitization profiles between gemcitabine and carboplatin and ATR kinase inhibitor ETP-46464 and Chk1 kinase inhibitor

  1. In-situ ATR-FTIR for characterization of thin biorelated polymer films

    International Nuclear Information System (INIS)

    Müller, M.; Torger, B.; Bittrich, E.; Kaul, E.; Ionov, L.; Uhlmann, P.; Stamm, M.

    2014-01-01

    We present and review in-situ-attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic data from thin biorelated polymer films useful for the modification and functionalization of polymer and inorganic materials and discuss their applications related to life sciences. A special ATR mirror attachment operated by the single-beam-sample-reference (SBSR) concept and housing a homebuilt thermostatable flow cell was used, which allows for appropriate background compensation and signal to noise ratio. ATR-FTIR data on the reactive deposition of dopamine on inorganic model surfaces are shown. Information on the structure and deposition pathway for such bioinspired melanin-like films is provided. ATR-FTIR data on thermosensitive polymer brushes of poly(N-isopropylacrylamide) (PNIPAAM) is then presented. The thermotropic hydration and hydrogen bonding behavior of PNIPAAM brush films is described. Finally, ATR-FTIR data on biorelated polyelectrolyte multilayers (PEM) are given together with details on PEM growth and detection. Applications of these latter films for biopassivation/activation and local drug delivery are addressed

  2. Mutation of serine 1333 in the ATR HEAT repeats creates a hyperactive kinase.

    Directory of Open Access Journals (Sweden)

    Jessica W Luzwick

    Full Text Available Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 creates a hyperactive kinase. In vitro and in cells, mutation of S1333 to alanine (S1333A-ATR causes elevated levels of kinase activity with and without the addition of the protein activator TOPBP1. S1333 mutations to glycine, arginine, or lysine also create a hyperactive kinase, while mutation to aspartic acid decreases ATR activity. S1333A-ATR maintains the G2 checkpoint and promotes completion of DNA replication after transient exposure to replication stress but the less active kinase, S1333D-ATR, has modest defects in both of these functions. While we find no evidence that S1333 is phosphorylated in cultured cells, our data indicate that small changes in the HEAT repeats can have large effects on kinase activity. These mutants may serve as useful tools for future studies of the ATR pathway.

  3. ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    DEFF Research Database (Denmark)

    Toledo Lazaro, Luis Ignacio; Altmeyer, Matthias; Rask, Maj-Britt

    2013-01-01

    origin firing generates an excess of single-stranded DNA that exhausts the nuclear pool of RPA. Partial reduction of RPA accelerated fork breakage, and forced elevation of RPA was sufficient to delay such "replication catastrophe" even in the absence of ATR activity. Conversely, unscheduled origin firing...... induced breakage of stalled forks even in cells with active ATR. Thus, ATR-mediated suppression of dormant origins shields active forks against irreversible breakage via preventing exhaustion of nuclear RPA. This study elucidates how replicating genomes avoid destabilizing DNA damage. Because cancer cells...

  4. Biographical Data in a Digital World 2015 : Proceedings of the First Conference on Biographical Data in a Digital World 2015, Amsterdam, The Netherlands, April 9, 2015.

    NARCIS (Netherlands)

    ter Braake, Serge; Fokkens, Antske; Sluijter, R.G.H.; Declerck, Thierry; Wandl-Vogt, Eveline

    2015-01-01

    Biographical Data in a Digital World 2015 brought together researchers from Computer Science and History working on digitized biographies from all over the world. This introduction to its proceedings provides our motivation for a conference on this topic, a short history of the origin of the event

  5. ATR National Scientific User Facility 2009 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    Todd R. Allen; Mitchell K. Meyer; Frances Marshall; Mary Catherine Thelen; Jeff Benson

    2010-11-01

    This report describes activities of the ATR NSUF from FY-2008 through FY-2009 and includes information on partner facilities, calls for proposals, users week and education programs. The report also contains project information on university research projects that were awarded by ATR NSUF in the fiscal years 2008 & 2009. This research is university-proposed researcher under a user facility agreement. All intellectual property from these experiments belongs to the university per the user agreement.

  6. ATR Technical Specification Upgrade Program

    International Nuclear Information System (INIS)

    McCracken, R.T.; Durney, J.L.; Freund, G.A.

    1990-01-01

    The Advanced Test Reactor (ATR) is a 250 MW, uranium-aluminum fueled test reactor which began full power operation in 1969. The initial operation was controlled by an Operating Limits document based on the original Safety Analysis Report. Additional safety bases were later developed to support Technical Specifications which were approved and implemented in 1977. The Technical Specifications which were initially developed with content and format specified in ANSI/ANS--15.1, ''The Development of Technical Specifications for Research Reactors.'' The safety basis documentation and the Technical Specifications have been updated as required to maintain them current with the ATR facility configuration. All revisions have been made with a content, format and style consistent with the original. A major, two-phase program to upgrade the content, format and style is in progress. This paper describes the first phase of this program

  7. Web-Enabled ATR/Fusion Development System

    National Research Council Canada - National Science Library

    Ruda, Harald

    2001-01-01

    .... We have designed a Web-Enabled ATR/Fusion Development System (WEADS) that will allow distributed development and execution of AIR and fusion algorithms using currently available infrastructures...

  8. Camp Creates a World of Magic: The Trail to Innovative Thinking Begins at the ACA National Conference.

    Science.gov (United States)

    Coleman, Marla

    2001-01-01

    The American Camping Association 2001 National Conference at Walt Disney World draws parallels between the administration of camp programs and practices at Disney World. Seminars led by Disney managers focus on recruitment of college students, development of a corporate culture and philosophy, emphasis on environment, and quality service that…

  9. ATR National Scientific User Facility 2009 Annual Report

    International Nuclear Information System (INIS)

    Allen, Todd R.; Meyer, Mitchell K.; Marshall, Frances; Thelen, Mary Catherine; Benson, Jeff

    2010-01-01

    This report describes activities of the ATR NSUF from FY-2008 through FY-2009 and includes information on partner facilities, calls for proposals, users week and education programs. The report also contains project information on university research projects that were awarded by ATR NSUF in the fiscal years 2008 and 2009. This research is university-proposed researcher under a user facility agreement. All intellectual property from these experiments belongs to the university per the user agreement.

  10. ATR kinase regulates its attenuation via PPM1D phosphatase ...

    Indian Academy of Sciences (India)

    In eukaryotes, in response to replication stress, DNA damage response kinase, ATR is activated, whose signalling abrogationleads to cell lethality due to aberrant fork remodelling and excessive origin firing. Here we report that inhibition ofATR kinase activity specifically during replication stress recovery results in persistent ...

  11. Status report of the ATR SPING-3A and detailed calibration guideline

    International Nuclear Information System (INIS)

    Koeppen, L.D.; Rogers, J.W.

    1985-12-01

    The Radiation Measurements Laboratory (RML) onducted testing and an evaluation of the ATR SPING-3 after installation of the new ''A'' series software (firmware) and retrofit kit. The purpose of this report is to provide the ATR SPING-3A users with a document describing the present status of the unit, how the system was tested, a suggested calibration guideline, how the system should be operated for the ATR application, and why it should be used in this manner

  12. UNESCO World Conference on Education for Sustainable Development: Learning Today for a Sustainable Future

    Science.gov (United States)

    Journal of Education for Sustainable Development, 2012

    2012-01-01

    The UNESCO World Conference on Education for Sustainable Development (ESD) will be co-organised in 2014 by UNESCO and the Government of Japan on the occasion of the end of the UN Decade of Education for Sustainable Development. It has the following objectives: (1) Celebrating a decade of action; (2) Reorienting education to build a better future…

  13. Homeostatic regulation of meiotic DSB formation by ATM/ATR

    International Nuclear Information System (INIS)

    Cooper, Tim J.; Wardell, Kayleigh; Garcia, Valerie; Neale, Matthew J.

    2014-01-01

    Ataxia–telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed

  14. Homeostatic regulation of meiotic DSB formation by ATM/ATR

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Tim J.; Wardell, Kayleigh; Garcia, Valerie; Neale, Matthew J., E-mail: m.neale@sussex.ac.uk

    2014-11-15

    Ataxia–telangiectasia mutated (ATM) and RAD3-related (ATR) are widely known as being central players in the mitotic DNA damage response (DDR), mounting responses to DNA double-strand breaks (DSBs) and single-stranded DNA (ssDNA) respectively. The DDR signalling cascade couples cell cycle control to damage-sensing and repair processes in order to prevent untimely cell cycle progression while damage still persists [1]. Both ATM/ATR are, however, also emerging as essential factors in the process of meiosis; a specialised cell cycle programme responsible for the formation of haploid gametes via two sequential nuclear divisions. Central to achieving accurate meiotic chromosome segregation is the introduction of numerous DSBs spread across the genome by the evolutionarily conserved enzyme, Spo11. This review seeks to explore and address how cells utilise ATM/ATR pathways to regulate Spo11-DSB formation, establish DSB homeostasis and ensure meiosis is completed unperturbed.

  15. European Research Framework Programme. Research on Climate Change. Prepared for the Third World Climate Conference (WCC-3) and the UNFCCC Conference of the Parties (COP-15)

    International Nuclear Information System (INIS)

    2009-01-01

    This publication gathers the abstracts of European research projects on climate change and related to climate change which have been completed recently or are ongoing under the sixth and seventh framework programmes for research. This document aims at providing a relevant overview of research activities on climate change funded by the European Community to participants to the third World Climate Conference held in Geneva in August 2009 and to the UNFCCC 15th Conference of the Parties meeting in Copenhagen in December 2009.

  16. ARF and ATM/ATR cooperate in p53-mediated apoptosis upon oncogenic stress

    International Nuclear Information System (INIS)

    Pauklin, Siim; Kristjuhan, Arnold; Maimets, Toivo; Jaks, Viljar

    2005-01-01

    Induction of apoptosis is pivotal for eliminating cells with damaged DNA or deregulated proliferation. We show that tumor suppressor ARF and ATM/ATR kinase pathways cooperate in the induction of apoptosis in response to elevated expression of c-myc, β-catenin or human papilloma virus E7 oncogenes. Overexpression of oncogenes leads to the formation of phosphorylated H2AX foci, induction of Rad51 protein levels and ATM/ATR-dependent phosphorylation of p53. Inhibition of ATM/ATR kinases abolishes both induction of Rad51 and phosphorylation of p53, and remarkably reduces the level of apoptosis induced by co-expression of oncogenes and ARF. However, the induction of apoptosis is downregulated in p53-/- cells and does not depend on activities of ATM/ATR kinases, indicating that efficient induction of apoptosis by oncogene activation depends on coordinated action of ARF and ATM/ATR pathways in the regulation of p53

  17. Protein phosphatase 5 is necessary for ATR-mediated DNA repair

    International Nuclear Information System (INIS)

    Kang, Yoonsung; Cheong, Hyang-Min; Lee, Jung-Hee; Song, Peter I.; Lee, Kwang-Ho; Kim, Sang-Yong; Jun, Jae Yeoul; You, Ho Jin

    2011-01-01

    Research highlights: → Serine/threonine protein phosphatase 5 (PP5) has been shown to participate in ataxia telangiectasia-mutated (ATM)- and ATR (ATM- and Rad3-related)-mediated checkpoint pathways, which plays an important role in the DNA damage response and maintenance of genomic stability. → However, it is not clear exactly how PP5 participates in this process. → Our results indicate that PP5 is more closely related with ATR-mediated pathway than ATM-mediated pathway in DNA damage repair. -- Abstract: Several recent studies have shown that protein phosphatase 5 (PP5) participates in cell cycle arrest after DNA damage, but its roles in DNA repair have not yet been fully characterized. We investigated the roles of PP5 in the repair of ultraviolet (UV)- and neocarzinostatin (NCS)-induced DNA damage. The results of comet assays revealed different repair patterns in UV- and NCS-exposed U2OS-PS cells. PP5 is only essential for Rad3-related (ATR)-mediated DNA repair. Furthermore, the phosphorylation of 53BP1 and BRCA1, important mediators of DNA damage repair, and substrates of ATR and ATM decreased in U2OS-PS cells exposed to UV radiation. In contrast, the cell cycle arrest proteins p53, CHK1, and CHK2 were normally phosphorylated in U2OS and U2OS-PS cells exposed to UV radiation or treated with NCS. In view of these results, we suggest that PP5 plays a crucial role in ATR-mediated repair of UV-induced DNA damage.

  18. ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations.

    Science.gov (United States)

    Cheng, Aifang; Zhao, Teng; Tse, Kai-Hei; Chow, Hei-Man; Cui, Yong; Jiang, Liwen; Du, Shengwang; Loy, Michael M T; Herrup, Karl

    2018-01-09

    ATM (ataxia-telangiectasia mutated) and ATR (ATM and Rad3-related) are large PI3 kinases whose human mutations result in complex syndromes that include a compromised DNA damage response (DDR) and prominent nervous system phenotypes. Both proteins are nuclear-localized in keeping with their DDR functions, yet both are also found in cytoplasm, including on neuronal synaptic vesicles. In ATM- or ATR-deficient neurons, spontaneous vesicle release is reduced, but a drop in ATM or ATR level also slows FM4-64 dye uptake. In keeping with this, both proteins bind to AP-2 complex components as well as to clathrin, suggesting roles in endocytosis and vesicle recycling. The two proteins play complementary roles in the DDR; ATM is engaged in the repair of double-strand breaks, while ATR deals mainly with single-strand damage. Unexpectedly, this complementarity extends to these proteins' synaptic function as well. Superresolution microscopy and coimmunoprecipitation reveal that ATM associates exclusively with excitatory (VGLUT1 + ) vesicles, while ATR associates only with inhibitory (VGAT + ) vesicles. The levels of ATM and ATR respond to each other; when ATM is deficient, ATR levels rise, and vice versa. Finally, blocking NMDA, but not GABA, receptors causes ATM levels to rise while ATR levels respond to GABA, but not NMDA, receptor blockade. Taken together, our data suggest that ATM and ATR are part of the cellular "infrastructure" that maintains the excitatory/inhibitory balance of the nervous system. This idea has important implications for the human diseases resulting from their genetic deficiency.

  19. Initial characterization of the ATR [Advanced Test Reactor] Large Gamma Facility

    International Nuclear Information System (INIS)

    Schnitzler, B.G.; Rogers, J.W.

    1986-05-01

    Radiation fields in the ATR Large Gamma Facility test volume are characterized. The preliminary characterization efforts described in this report include total dose rate measurements in the facility, development of a simple methodology for calculating radiation fields from the ATR fuel element power histories, and a comparison of the measured and calculated values

  20. Vatican is lone opponent of world conference's compromises on abortion.

    Science.gov (United States)

    1994-09-07

    Three years in the making, the draft program of action of the 1994 International Conference on Population and Development sets nonbinding policy guidelines to contain the world's population at 7.27 billion in 2015. Although the Vatican was pleased to see Pakistan put forward a compromise formula developed to appease Catholic and Muslim objectors of abortion, the Church was unprepared to accept the compromise immediately and requested further discussion. The Vatican's rejection drew a strong chorus of vocal disapproval from other conference delegates. Even Iran accepted the draft as a "perfect text," while Sweden grudgingly accepted it as a "rock-bottom compromise." With no Catholic countries objecting to the compromise, the Vatican stood alone in its refusal to compromise with the rest of the world's leaders and peoples. Germany, speaking for the European Union, warned that enough concessions had already been made. The rationale for Vatican opposition was unclear since the section explicitly rejects abortion as a means of family planning and urges countries to minimize both the incidence of unsafe abortion and abortion overall by improving family planning. Prevention of unwanted pregnancies must be given highest priority and women should have ready access to compassionate counselling, with abortion never promoted as a means of family planning. Moreover, there is no longer a reference to sexual health education, a plea to governments to review their laws and policies on abortion, and a call to consider women's health rather than relying upon criminal codes and punitive measures. Participants said the Vatican objected to a phrase stating that abortions, where legal, should be safe, while the Church representative argued that any suggestion that abortion is safe contradicts church doctrine on the sanctity of life.

  1. PUREX new substation ATR

    International Nuclear Information System (INIS)

    Nelson, D.E.

    1997-01-01

    This document is the acceptance test report (ATR) for the New PUREX Main and Minisubstations. It covers the factory and vendor acceptance and commissioning test reports. Reports are presented for the Main 5 kV substation building, the building fire system, switchgear, and vacuum breaker; the minisubstation control building and switch gear; commissioning test; electrical system and loads inspection; electrical utilities transformer and cable; and relay setting changes based on operational experience

  2. WebNet 99 : proceedings of WebNet 99 - World Conference on the WWW and Internet, Honolulu, Hawaii, October 24-30, 1999

    NARCIS (Netherlands)

    De Bra, P.M.E.; Leggett, J.

    1999-01-01

    The 1999 WebNet conference addressed research, new developments, and experiences related to the Internet and World Wide Web. The 394 contributions of WebNet 99 contained in this proceedings comprise the full and short papers accepted for presentation at the conference. Major topics covered include:

  3. ATR and transmission analysis of pigments by means of far infrared spectroscopy.

    Science.gov (United States)

    Kendix, Elsebeth L; Prati, Silvia; Joseph, Edith; Sciutto, Giorgia; Mazzeo, Rocco

    2009-06-01

    In the field of FTIR spectroscopy, the far infrared (FIR) spectral region has been so far less investigated than the mid-infrared (MIR), even though it presents great advantages in the characterization of those inorganic compounds, which are inactive in the MIR, such as some art pigments, corrosion products, etc. Furthermore, FIR spectroscopy is complementary to Raman spectroscopy if the fluorescence effects caused by the latter analytical technique are considered. In this paper, ATR in the FIR region is proposed as an alternative method to transmission for the analyses of pigments. This methodology was selected in order to reduce the sample amount needed for analysis, which is a must when examining cultural heritage materials. A selection of pigments have been analyzed in both ATR and transmission mode, and the resulting spectra were compared with each other. To better perform this comparison, an evaluation of the possible effect induced by the thermal treatment needed for the preparation of the polyethylene pellets on the transmission spectra of the samples has been carried out. Therefore, pigments have been analyzed in ATR mode before and after heating them at the same temperature employed for the polyethylene pellet preparation. The results showed that while the heating treatment causes only small changes in the intensity of some bands, the ATR spectra were characterized by differences in both intensity and band shifts towards lower frequencies if compared with those recorded in transmission mode. All pigments' transmission and ATR spectra are presented and discussed, and the ATR method was validated on a real case study.

  4. 2008 Gordon Research Conference on Catalysis [Conference summary report

    Energy Technology Data Exchange (ETDEWEB)

    Soled, Stuart L.; Gray, Nancy Ryan

    2009-01-01

    The GRC on Catalysis is one of the most prestigious catalysis conferences as it brings together leading researchers from around the world to discuss their latest, most exciting work in catalysis. The 2008 conference will continue this tradition. The conference will cover a variety of themes including new catalytic materials, theoretical and experimental approaches to improve understanding of kinetics and transport phenomena, and state of the art nanoscale characterization probes to monitor active sites. The conference promotes interactions among established researchers and young scientists. It provides a venue for students to meet, talk to and learn from some of the world leading researchers in the area. It also gives them a platform for displaying their own work during the poster sessions. The informal nature of the meeting, excellent quality of the presentations and posters, and ability to meet many outstanding colleagues makes this an excellent conference.

  5. World nuclear power once again in the spotlight. Comments on the 13th Pacfic Basin Nuclear Conference

    International Nuclear Information System (INIS)

    Zang Mingchang; Ruan Keqiang

    2004-01-01

    This paper comments on The 13th Pacific Basin Nuclear Conference held in Shenzhen, China, on October 21/25, 2002 and summarizes some key papers presented in the Conference and viewpoints from their following discussions, which indicates that nuclear power in the world is once again in the spotlight. The Conference shows that in the coming 50 years the roadmap to develop nuclear energy would be divided into two stages: Near-Term Deployment by 2010-2015, some advanced designs were developed for Utilities; Generation IV Program, its overall goal is to identify and develop next-generation nuclear power systems that could be deployed over the next 30 years to help meet the world's energy needs throughout the 21st century. Some visions is the future, such as co-generation of electricity and space heating or desalination, and combination of Generation IV and so-called Hydrogen Economy-the use of hydrogen in vehicle transport to replace petroleum, were presented. As a primary energy source nuclear power is particularly well suited to hydrogen production, offering the almost unique position of large-scale hydrogen production with near-zero emissions. (authors)

  6. A chain reaction: the Fourth World Conference on Women and beyond.

    Science.gov (United States)

    Sarkar, D

    1995-01-01

    The UN's Fourth World Conference on Women, held in September 1995 in Beijing, China, fostered international dialogue on complex issues related to women. The Platform of Action maps the boundaries that confine women and recommends actions to redress key concerns, including poverty, violence, education health, the environment, and political and social status. National and regional studies throughout the world show that a great number of women are pushed into prostitution, are sexually abused, raped, forcibly sterilized, and coerced into having abortions. In the US, nearly 4 million women are physically abused every year, according to a 1994 US Department of State report on the status of women. The 1995 UN Human Development Report estimates that one American woman in six is raped in her lifetime. The Beijing document underscores education as a way to empower women and help to break patterns of violence and discrimination. It is estimated that women perform 60% of the world's work but earn only 10% of the world's income and own less that 1% of the world's assets. Governments, institutions, and nongovernmental organizations (NGOs) pledged monetary support to develop programs that are favorable toward women. The US announced that a 6-year $1.5 billion program will fight domestic violence, and additional proposals include increasing resources to combat the spread of HIV/AIDS, decrease smoking and breast cancer, improve wages and conditions for women in the workplace, expand financial credit for women, and promote their participation in the political process. In addition, the World Bank has pledged to spend $5 billion of its $20 billion annual lending to address the particular concerns of women and to target $200 million for miniloans to help women start their own businesses. Throughout the world, education and family planning projects have helped women make informed choices about their families, resulting in improved reproductive health and lower fertility rates.

  7. DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

    Science.gov (United States)

    Enriquez-Rios, Vanessa; Dumitrache, Lavinia C; Downing, Susanna M; Li, Yang; Brown, Eric J; Russell, Helen R; McKinnon, Peter J

    2017-01-25

    The DNA damage response (DDR) orchestrates a network of cellular processes that integrates cell-cycle control and DNA repair or apoptosis, which serves to maintain genome stability. DNA-PKcs (the catalytic subunit of the DNA-dependent kinase, encoded by PRKDC), ATM (ataxia telangiectasia, mutated), and ATR (ATM and Rad3-related) are related PI3K-like protein kinases and central regulators of the DDR. Defects in these kinases have been linked to neurodegenerative or neurodevelopmental syndromes. In all cases, the key neuroprotective function of these kinases is uncertain. It also remains unclear how interactions between the three DNA damage-responsive kinases coordinate genome stability, particularly in a physiological context. Here, we used a genetic approach to identify the neural function of DNA-PKcs and the interplay between ATM and ATR during neurogenesis. We found that DNA-PKcs loss in the mouse sensitized neuronal progenitors to apoptosis after ionizing radiation because of excessive DNA damage. DNA-PKcs was also required to prevent endogenous DNA damage accumulation throughout the adult brain. In contrast, ATR coordinated the DDR during neurogenesis to direct apoptosis in cycling neural progenitors, whereas ATM regulated apoptosis in both proliferative and noncycling cells. We also found that ATR controls a DNA damage-induced G 2 /M checkpoint in cortical progenitors, independent of ATM and DNA-PKcs. These nonoverlapping roles were further confirmed via sustained murine embryonic or cortical development after all three kinases were simultaneously inactivated. Thus, our results illustrate how DNA-PKcs, ATM, and ATR have unique and essential roles during the DDR, collectively ensuring comprehensive genome maintenance in the nervous system. The DNA damage response (DDR) is essential for prevention of a broad spectrum of different human neurologic diseases. However, a detailed understanding of the DDR at a physiological level is lacking. In contrast to many in

  8. Advanced Test Reactor (ATR) Facility 10CFR830 Safety Basis Related to Facility Experiments

    International Nuclear Information System (INIS)

    Tomberlin, T.A.

    2002-01-01

    The Idaho National Engineering and Environmental Laboratory (INEEL) Advanced Test Reactor (ATR), a DOE Category A reactor, was designed to provide an irradiation test environment for conducting a variety of experiments. The ATR Safety Analysis Report, determined by DOE to meet the requirements of 10 CFR 830, Subpart B, provides versatility in types of experiments that may be conducted. This paper addresses two general types of experiments in the ATR facility and how safety analyses for experiments are related to the ATR safety basis. One type of experiment is more routine and generally represents greater risks; therefore this type of experiment is addressed with more detail in the safety basis. This allows individual safety analyses for these experiments to be more routine and repetitive. The second type of experiment is less defined and is permitted under more general controls. Therefore, individual safety analyses for the second type of experiment tend to be more unique from experiment to experiment. Experiments are also discussed relative to ''major modifications'' and DOE-STD-1027-92. Application of the USQ process to ATR experiments is also discussed

  9. 2nd world TRIGA users conference. Conference volume

    International Nuclear Information System (INIS)

    2004-01-01

    This conference was organized by the Atomic Institute of the Austrian Universities (University of Technology Vienna), it was devoted to present results in the operation of TRIGA research reactors. The main general topics were: a) reactor operation experience, b)neutron and solid state physics, c) radiochemistry and activation analysis, d) medical applications (boron neutron capture therapy, labeled compounds), e) reactor related experiments and calculations, f) waste management and decommissioning of TRIGA reactors. (nevyjel)

  10. 2nd world TRIGA users conference. Conference volume

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    This conference was organized by the Atomic Institute of the Austrian Universities (University of Technology Vienna), it was devoted to present results in the operation of TRIGA research reactors. The main general topics were: a) reactor operation experience, b)neutron and solid state physics, c) radiochemistry and activation analysis, d) medical applications (boron neutron capture therapy, labeled compounds), e) reactor related experiments and calculations, f) waste management and decommissioning of TRIGA reactors. (nevyjel)

  11. L'Atrésie colique:À propos de deux cas

    African Journals Online (AJOL)

    ... dans un tableau d'occlusion néonatale haute. L'atrésie colique était de découverte fortuite en per-opératoire, associée à une atrésie grêlique. Le patient a bénéficié d'une double stomie, mais les suites opératoires ont été marquées par le décès dans un tableau de choc septique. A la lumière des ces deux observations ...

  12. A Shld1-controlled POT1a provides support for repression of ATR signaling at telomeres through RPA exclusion.

    Science.gov (United States)

    Gong, Yi; de Lange, Titia

    2010-11-12

    We previously proposed that POT1 prevents ATR signaling at telomeres by excluding RPA from the single-stranded TTAGGG repeats. Here, we use a Shld1-stabilized degron-POT1a fusion (DD-POT1a) to study the telomeric ATR kinase response. In the absence of Shld1, DD-POT1a degradation resulted in rapid and reversible activation of the ATR pathway in G1 and S/G2. ATR signaling was abrogated by shRNAs to ATR and TopBP1, but shRNAs to the ATM kinase or DNA-PKcs did not affect the telomere damage response. Importantly, ATR signaling in G1 and S/G2 was reduced by shRNAs to RPA. In S/G2, RPA was readily detectable at dysfunctional telomeres, and both POT1a and POT1b were required to exclude RPA and prevent ATR activation. In G1, the accumulation of RPA at dysfunctional telomeres was strikingly less, and POT1a was sufficient to repress ATR signaling. These results support an RPA exclusion model for the repression of ATR signaling at telomeres. Copyright © 2010 Elsevier Inc. All rights reserved.

  13. Generation and assessment of turntable SAR data for the support of ATR development

    Science.gov (United States)

    Cohen, Marvin N.; Showman, Gregory A.; Sangston, K. James; Sylvester, Vincent B.; Gostin, Lamar; Scheer, C. Ruby

    1998-10-01

    Inverse synthetic aperture radar (ISAR) imaging on a turntable-tower test range permits convenient generation of high resolution two-dimensional images of radar targets under controlled conditions for testing SAR image processing and for supporting automatic target recognition (ATR) algorithm development. However, turntable ISAR images are often obtained under near-field geometries and hence may suffer geometric distortions not present in airborne SAR images. In this paper, turntable data collected at Georgia Tech's Electromagnetic Test Facility are used to begin to assess the utility of two- dimensional ISAR imaging algorithms in forming images to support ATR development. The imaging algorithms considered include a simple 2D discrete Fourier transform (DFT), a 2-D DFT with geometric correction based on image domain resampling, and a computationally-intensive geometric matched filter solution. Images formed with the various algorithms are used to develop ATR templates, which are then compared with an eye toward utilization in an ATR algorithm.

  14. Characterization and sintering of niobium-ATR alumina

    International Nuclear Information System (INIS)

    Sibuya, N.H.; Iwasaki, H.; Suzuki, C.K.; Pinatti, D.G.

    1987-01-01

    In the niobium aluminothermy a slag is produced, composed mostly of alumina and other compounds such as niobium oxide and silica. The phase composition of this ATR alumina was characterized by X-ray powder diffractometry, and afterwards this alumina was subjected to leaching processes. It was noticed that the original content of 70% α-alumina in slag rose to 95% after the calcination. ATR alumina (leached and calcined, and without any treatment) was used to make pressed bodies which were fired in air at 1200 to 1400 0 C for 1 to 10,5 hours; and in vacuum at 1550 to 1800$0C for 2 hours. Characterization was done by density measurements, X-ray diffractometry and ultrasonic analysis. Ultrasonic analysis of some vacuum fired bodies showed londitudinal velocities close to the value found in literature. Correlation of several techniques measurements disclosed the niobium oxide interference in sintering. (Author) [pt

  15. Efficacy of ATR inhibitors as single agents in Ewing sarcoma

    DEFF Research Database (Denmark)

    Nieto-Soler, Maria; Morgado-Palacin, Isabel; Lafarga, Vanesa

    2016-01-01

    Ewing sarcomas (ES) are pediatric bone tumors that arise from a driver translocation, most frequently EWS/FLI1. Current ES treatment involves DNA damaging agents, yet the basis for the sensitivity to these therapies remains unknown. Oncogene-induced replication stress (RS) is a known source...... efficacy in ES xenografts as single agents. Expression of EWS/FLI1 or EWS/ERG oncogenic translocations sensitizes non-ES cells to ATR inhibitors. Our data shed light onto the sensitivity of ES to genotoxic agents, and identify ATR inhibitors as a potential therapy for Ewing Sarcomas....

  16. World Climate Conference - a play re-enacting the COPs

    Science.gov (United States)

    Vamborg, Freja S. E.; Klockmann, Marlene; Koch, Boris P.; Otto, Juliane; Rauser, Florian; Schemann, Vera; Sonntag, Sebastian; Haug, Helgard; Kaegi, Stefan; Wetzel, Daniel; Schipper, Imanuel; Bochow, Jörg

    2016-04-01

    Last December, Paris was the host city for the 21st Conference of the Parties (COP21) of the United Nations Framework Convention on Climate Change (UNFCCC). Representatives of 195 countries met to dispute a legally binding climate agreement - a highly complex process involving thousands of politicians, scientists and activists, that to date has taken over two decades. The director ensemble "Rimini Protokoll" re-enacted this mammoth-scale drama of diplomacy in the play "Weltklimakonferenz" (World Climate Conference) at the "Deutsches Schauspielhaus" theatre in Hamburg, Germany. Since the opening night (21st Nov. 2014), the play has been performed 16 times, reaching an audience of over 9000. All performers in the play were experts and scientists at different stages of their careers, including PhD students, journalists and professors. Each spectator took on the identity of a delegate of one of the 195 participating countries. We will present the project and the performance, thereby highlighting the role of and the interaction between the spectators and early career scientists. In a nutshell the play went as follows (https://vimeo.com/137817619); after an opening ceremony, the audience was divided up into seven groups, each of which was given advice by experts in several different briefings. These informed on country-specific challenges caused by the social and economic situation, possible future climatic changes and negotiating tactics. In addition, the delegations had bilateral meetings, enabling them to exchange views and experiences with one another. Towards the end of the play each delegation was asked to submit a national commitment to greenhouse gas reduction and a financial contribution to the Green Climate Fund. Based on these national commitments, the final plenum revealed whether or not the delegations had managed to submit reductions compatible with restricting global warming to 2°C compared to pre-industrial times. Due to their direct personal involvement

  17. White Paper Report of the 2010 RAD-AID Conference on International Radiology for Developing Countries: Identifying Sustainable Strategies for Imaging Services in the Developing World

    Science.gov (United States)

    Welling, Rodney D.; Azene, Ezana M.; Kalia, Vivek; Pongpirul, Krit; Starikovsky, Anna; Sydnor, Ryan; Lungren, Matthew P.; Johnson, Benjamin; Kimble, Cary; Wiktorek, Sarah; Drum, Tom; Short, Brad; Cooper, Justin; Khouri, Nagi F.; Mayo-Smith, William W.; Mahesh, Mahadevappa; Goldberg, Barry B.; Garra, Brian S.; DeStigter, Kristen K.; Lewin, Jonathan S.; Mollura, Daniel J.

    2015-01-01

    The 2010 RAD-AID Conference on International Radiology for Developing Countries was a multidisciplinary meeting to discuss data, experiences, and models pertaining to radiology in the developing world, where widespread shortages of imaging services reduce health care quality. The theme of this year’s conference was sustainability, with a focus on establishing and maintaining imaging services in resource-limited regions. Conference presenters and participants identified 4 important components of sustainability: (1) sustainable financing models for radiology development, (2) integration of radiology and public health, (3) sustainable clinical models and technology solutions for resource-limited regions, and (4) education and training of both developing and developed world health care personnel. PMID:21807349

  18. Roles of ATR1 paralogs YMR279c and YOR378w in boron stress tolerance

    International Nuclear Information System (INIS)

    Bozdag, Gonensin Ozan; Uluisik, Irem; Gulculer, Gulce Sila; Karakaya, Huseyin C.; Koc, Ahmet

    2011-01-01

    Highlights: → ATR1 paralog YMR279c plays role in boron detoxification. → YMR279c overexpression lowers cytoplasmic boron levels. → ATR1 paralog YOR378w has no roles in boron stress response. -- Abstract: Boron is a necessary nutrient for plants and animals, however excess of it causes toxicity. Previously, Atr1 and Arabidopsis Bor1 homolog were identified as the boron efflux pump in yeast, which lower the cytosolic boron concentration and help cells to survive in the presence of toxic amount of boron. In this study, we analyzed ATR1 paralogs, YMR279c and YOR378w, to understand whether they participate in boron stress tolerance in yeast. Even though these genes share homology with ATR1, neither their deletion rendered cells boron sensitive nor their expression was significantly upregulated by boron treatment. However, expression of YMR279, but not YOR378w, from the constitutive GAPDH promoter on a high copy plasmid provided remarkable boron resistance by decreasing intracellular boron levels. Thus our results suggest the presence of a third boron exporter, YMR279c, which functions similar to ATR1 and provides boron resistance in yeast.

  19. Pressure-modulation dynamic attenuated-total-reflectance (ATR) FT-IR spectroscopy

    Science.gov (United States)

    Marcott, C.; Story, G. M.; Noda, I.; Bibby, A.; Manning, C. J.

    1998-06-01

    A single-reflectance attenuated-total-reflectance (ATR) accessory with a diamond internal-reflection element was modified by the addition of a piezoelectric transducer. Initial dynamic pressure-modulation experiments have been performed in the sample compartment of a step-scanning FT-IR spectrometer. A sinusoidal pressure modulation applied to samples of isotactic polypropylene and linear low density polyethylene resulted in dynamic responses which appear to be similar to those observed in previous dynamic 2D IR experiments. Preliminary pressure-modulation dynamic ATR results are also reported for a styrene-butadiene-styrene triblock copolymer. The new method has the advantages that a much wider variety of sample types and geometries can be studied and less sample preparation is required. Dynamic 2D IR experiments carried out by ATR no longer require thin films of large area and sufficient strength to withstand the dynamic strain applied by a rheometer. The ability to obtain dynamic IR spectroscopic information from a wider variety of sample types and thicknesses would greatly expand the amount of useful information that could be extracted from normally complicated, highly overlapped IR spectra.

  20. SAR image dataset of military ground targets with multiple poses for ATR

    Science.gov (United States)

    Belloni, Carole; Balleri, Alessio; Aouf, Nabil; Merlet, Thomas; Le Caillec, Jean-Marc

    2017-10-01

    Automatic Target Recognition (ATR) is the task of automatically detecting and classifying targets. Recognition using Synthetic Aperture Radar (SAR) images is interesting because SAR images can be acquired at night and under any weather conditions, whereas optical sensors operating in the visible band do not have this capability. Existing SAR ATR algorithms have mostly been evaluated using the MSTAR dataset.1 The problem with the MSTAR is that some of the proposed ATR methods have shown good classification performance even when targets were hidden,2 suggesting the presence of a bias in the dataset. Evaluations of SAR ATR techniques are currently challenging due to the lack of publicly available data in the SAR domain. In this paper, we present a high resolution SAR dataset consisting of images of a set of ground military target models taken at various aspect angles, The dataset can be used for a fair evaluation and comparison of SAR ATR algorithms. We applied the Inverse Synthetic Aperture Radar (ISAR) technique to echoes from targets rotating on a turntable and illuminated with a stepped frequency waveform. The targets in the database consist of four variants of two 1.7m-long models of T-64 and T-72 tanks. The gun, the turret position and the depression angle are varied to form 26 different sequences of images. The emitted signal spanned the frequency range from 13 GHz to 18 GHz to achieve a bandwidth of 5 GHz sampled with 4001 frequency points. The resolution obtained with respect to the size of the model targets is comparable to typical values obtained using SAR airborne systems. Single polarized images (Horizontal-Horizontal) are generated using the backprojection algorithm.3 A total of 1480 images are produced using a 20° integration angle. The images in the dataset are organized in a suggested training and testing set to facilitate a standard evaluation of SAR ATR algorithms.

  1. International Conference on Nuclear Security: Enhancing Global Efforts. Summary of an International Conference

    International Nuclear Information System (INIS)

    2014-01-01

    The International Conference on Nuclear Security: Enhancing Global Efforts was organized by the IAEA and held in Vienna on 1-5 July 2013. The conference was organized in cooperation with the following organizations and initiatives: the European Union; the Global Initiative to Combat Nuclear Terrorism (GICNT); the International Criminal Police Organization (INTERPOL); the Institute of Nuclear Materials Management (INMM); the Nuclear Threat Initiative (NTI); the Organization for Security and Co-operation in Europe (OSCE); the Partnership for Global Security; the Police Community of the Americas (AMERIPOL); the United Nations Interregional Crime and Justice Research Institute (UNICRI); the United Nations Office on Drugs and Crime (UNODC); the World Institute for Nuclear Security (WINS); the World Nuclear Association (WNA); and the World Nuclear Transport Institute (WNTI). A total of 34 ministers participated in the ministerial session of the conference. Altogether, the conference attracted more than 1300 registered participants from 125 IAEA Member States and 21 organizations. The aim of the conference was to review the international community's experience and achievements to date in strengthening nuclear security, to enhance the understanding of current approaches to nuclear security worldwide and identify trends, and to provide a global forum for ministers, policymakers and senior officials to formulate views on future directions and priorities for nuclear security. This book contains the President's Summary of the conference and a summary of the ministerial session, the full text of the ministerial declaration adopted by the conference and summaries of the main conference sessions. The attached CD-ROM contains the full conference programme, the list of conference participants, the national statements from the ministerial session and a selection of papers

  2. Mox fuel utilization in ATR

    OpenAIRE

    下村 和生; 川太 徳夫

    1987-01-01

    ATR, a heavy-water moderated boiling-light-water cooled reactor developed in Japan, is a unique reactor with out-standing flexibility regarding nuclear fuel utilization, because it has superior properties concerning the utilization of plutonium, recovered uranium and depleted uranium. The development of this type of reactor is expected to contribute both to the stable supply of energy and to the establishment of plutonium utilization in Japan. Much effort has been and will be made on the deve...

  3. RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

    OpenAIRE

    Kar, Ananya; Kaur, Manpreet; Ghosh, Tanushree; Khan, Md. Muntaz; Sharma, Aparna; Shekhar, Ritu; Varshney, Akhil; Saxena, Sandeep

    2015-01-01

    The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated checkpoint response. We report that in the absence of RPA, human single-stranded DNA-binding protein 1 (hSSB1) and its partner protein INTS3 form sub-nuclear foci, associate with the ATR-ATRIP comp...

  4. White Paper Report of the 2011 RAD-AID Conference on International Radiology for Developing Countries: Integrating Multidisciplinary Strategies for Imaging Services in the Developing World

    Science.gov (United States)

    Mazal, Jonathan; Lexa, Frank; Starikovsky, Anna; Jimenez, Pablo; Jain, Sanjay; DeStigter, Kristen K.; Nathan, Robert; Krebs, Elizabeth; Noble, Vicki; Marks, William; Hirsh, Richard N.; Short, Brad; Sydnor, Ryan; Timmreck-Jackson, Emily; Lungren, Matthew P.; Maxfield, Charles; Azene, Ezana M.; Garra, Brian S.; Choi, Brian G.; Lewin, Jonathan S.; Mollura, Daniel J.

    2016-01-01

    The 2011 RAD-AID Conference on International Radiology for Developing Countries discussed data, experiences and models pertaining to radiology in the developing world, where widespread shortages of imaging services significantly reduce health care quality and increase health care disparity. This white paper from the 2011 RAD-AID Conference represents consensus advocacy of multidisciplinary strategies to improve planning, accessibility and quality of imaging services in the developing world. Conference presenters and participants discussed numerous solutions to imaging and healthcare disparities including: (1) economic development for radiology service planning, (2) public health mechanisms to address disease and prevention at the population and community levels, (3) comparative clinical models to implement various clinical and workflow strategies adapted to unique developing world community contexts, (4) education to improve training and optimize service quality, and (5) technology innovation to bring new technical capabilities to limited-resource regions. PMID:22748790

  5. Proceedings of the 2. world conference on Pellets

    International Nuclear Information System (INIS)

    2006-07-01

    The conference and exhibition had over 1000 participants from 60 different countries. Subject areas covered by the conference were: Raw Materials For Densification; Pellet Production Technologies; Pellet Burning Technologies; Supply Chain Logistics; Environmental Issues; Marketing of Densified Fuels; Co-Generation of Heat and Electricity from Densified Fuels; 57 contributions have been separately indexed for the database

  6. Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase (ATR) sensitize lymphoma cells to UVA radiation

    DEFF Research Database (Denmark)

    Biskup, Edyta; Naym, David Gram; Gniadecki, Robert

    2016-01-01

    inhibited by small molecule antagonists VE-821, VE-822 or Chir-124, or by small interfering RNAs (siRNAs). Cell cycle and viability were assessed by flow cytometry. RESULTS: Small molecule inhibitors of ATR and Chk1 potently sensitized all cell lines to PUVA and, importantly, also to UVA, which by itself...... did not cause apoptotic response. VE-821/2 blocked ATR pathway activation and released the cells from the G2/M block caused by UVA and PUVA, but did not affect apoptosis caused by other chemotherapeutics (etoposide, gemcitabine, doxorubicine) or by hydrogen peroxide. Knockdown of ATR and Chk1 with si......RNA also blocked the ATR pathway and released the cells from G2/M block but did not sensitize the cells to UVA as observed with the small molecule inhibitors. The latter suggested that the synergism between VE-821/2 or Chir-124 and UVA was not solely caused by specific blocking of ATR kinase but also ATR...

  7. 18th world hydrogen energy conference 2010. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This CD-ROM contains lectures, power points slides and posters presented on the 18th World Hydrogen Energy Conference. The topics of the conference are: (A). Fuel Cell Basics: 1. Electrochemistry of PEM Fuell Cells; 2. PEM/HT-PEM Fuel Cells: Electrolytes, Stack Components; 3. Direct Fuel Cells; 4. High-Temperature Fuel Cells; 5. Advanced Modelling (B). Existing and Emerging Markets: 1. Off-Grid Power Supply and Premium Power Generation; 2. Space and Aeronautic Applications; 3. APUs for LDV, Trucks, Ships and Airplanes; 4. Portable Applications and Light Traction. (C). Stationary Applications: 1. High-Temperature Fuel Cells; 2. Fuell Cells for Buildings. (D). Transportation Applications: 1. Fuel-Cell Power Trains; 3. Hydrogen Internal Combustion Engines; 4. Systems Analysis and Well-to-Wheel Studies; 5. Demonstration Projects, Costs and Market Introduction; 6 Electrification in Transportation Systems. (E). Fuel Infrastructures: 1. Hydrogen Distribution Technologies; 2. Hydrogen Deployment; 3. Fuel Provision for Early Market Applications. (G). Hydrogen Production Technologies: 1a. Photobiological Hydrogen Production; 1b. Fermentative Hydrogen Production; 1c. The HYVOLUTION Project. (H). Thermochemical Cycles: 3a. Hydrogen from Renewable Electricity; 3b. High-Temperature Electrolysis; 3c Alcaline Electrolysis; 3d PEM Electrolysis; 4a Reforming and Gasification-Fossil Energy Carriers; 4b Reforming and Gasification-Biomass; 5. Hydrogen-Separation Membranes; 6. Hydrogen Systems Assessment;.7. Photocatalysis (I). Storages: 1. Physical Hydrogen Storage; 2a. Metal Hydrides; 2b. Complex Hydrides; 3. Adsorption Technologies; (J). Strategic Analyses: 1. Research + Development Target and Priorities; 2. Life-Cycle Assessment and Economic Impact; 3. Socio-Economic Studies; 4. Education and Public Awareness; 5. Market Introduction; 7. Regional Activities; 8. The Zero Regio Project. (K). Safety Issues: 1. Vehicle and Infrastructural Safety; 2. Regulations, Codes, Standards and Test

  8. 18th world hydrogen energy conference 2010. Proceedings

    International Nuclear Information System (INIS)

    2010-01-01

    This CD-ROM contains lectures, power points slides and posters presented on the 18th World Hydrogen Energy Conference. The topics of the conference are: (A). Fuel Cell Basics: 1. Electrochemistry of PEM Fuell Cells; 2. PEM/HT-PEM Fuel Cells: Electrolytes, Stack Components; 3. Direct Fuel Cells; 4. High-Temperature Fuel Cells; 5. Advanced Modelling (B). Existing and Emerging Markets: 1. Off-Grid Power Supply and Premium Power Generation; 2. Space and Aeronautic Applications; 3. APUs for LDV, Trucks, Ships and Airplanes; 4. Portable Applications and Light Traction. (C). Stationary Applications: 1. High-Temperature Fuel Cells; 2. Fuell Cells for Buildings. (D). Transportation Applications: 1. Fuel-Cell Power Trains; 3. Hydrogen Internal Combustion Engines; 4. Systems Analysis and Well-to-Wheel Studies; 5. Demonstration Projects, Costs and Market Introduction; 6 Electrification in Transportation Systems. (E). Fuel Infrastructures: 1. Hydrogen Distribution Technologies; 2. Hydrogen Deployment; 3. Fuel Provision for Early Market Applications. (G). Hydrogen Production Technologies: 1a. Photobiological Hydrogen Production; 1b. Fermentative Hydrogen Production; 1c. The HYVOLUTION Project. (H). Thermochemical Cycles: 3a. Hydrogen from Renewable Electricity; 3b. High-Temperature Electrolysis; 3c Alcaline Electrolysis; 3d PEM Electrolysis; 4a Reforming and Gasification-Fossil Energy Carriers; 4b Reforming and Gasification-Biomass; 5. Hydrogen-Separation Membranes; 6. Hydrogen Systems Assessment;.7. Photocatalysis (I). Storages: 1. Physical Hydrogen Storage; 2a. Metal Hydrides; 2b. Complex Hydrides; 3. Adsorption Technologies; (J). Strategic Analyses: 1. Research + Development Target and Priorities; 2. Life-Cycle Assessment and Economic Impact; 3. Socio-Economic Studies; 4. Education and Public Awareness; 5. Market Introduction; 7. Regional Activities; 8. The Zero Regio Project. (K). Safety Issues: 1. Vehicle and Infrastructural Safety; 2. Regulations, Codes, Standards and Test

  9. ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function

    DEFF Research Database (Denmark)

    Ahlskog, Johanna K; Larsen, Brian D; Achanta, Kavya

    2016-01-01

    DNA damage activates the ATM and ATR kinases that coordinate checkpoint and DNA repair pathways. An essential step in homology-directed repair (HDR) of DNA breaks is the formation of RAD51 nucleofilaments mediated by PALB2-BRCA2; however, roles of ATM and ATR in this critical step of HDR are poor...... function, as the PALB2-dependent checkpoint response is normal in cells expressing the phospho-deficient PALB2 mutant. Collectively, our findings highlight a critical importance of PALB2 phosphorylation as a novel regulatory step in genome maintenance after genotoxic stress....

  10. International Conference on Physics

    CERN Document Server

    2016-01-01

    OMICS International, (conference series) the World Class Open Access Publisher and Scientific Event Organizer is hosting “International Conference on physics” which is going to be the biggest conference dedicated to Physics. The theme “Highlighting innovations and challenges in the field of Physics” and it features a three day conference addressing the major breakthroughs, challenges and the solutions adopted. The conference will be held during June 27-29, 2016 at New Orleans, USA. Will be published in: http://physics.conferenceseries.com/

  11. AGR-3/4 Final Data Qualification Report for ATR Cycles 151A through 155B-1

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Binh T. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    This report provides the qualification status of experimental data for the entire Advanced Gas Reactor 3/4 (AGR 3/4) fuel irradiation. AGR-3/4 is the third in a series of planned irradiation experiments conducted in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) for the AGR Fuel Development and Qualification Program, which supports development of the advanced reactor technology under the INL ART Technology Development Office (TDO). The main objective of AGR-3/4 irradiation is to provide a known source of fission products for subsequent transport through compact matrix and structural graphite materials due to the presence of designed-to-fail fuel particles. Full power irradiation of the AGR 3/4 test began on December 14, 2011 (ATR Cycle 151A), and was completed on April 12, 2014 (end of ATR Cycle 155B) after 369.1 effective full power days of irradiation. The AGR-3/4 test was in the reactor core for eight of the ten ATR cycles between 151A and 155B. During the unplanned outage cycle, 153A, the experiment was removed from the ATR northeast flux trap (NEFT) location and stored in the ATR canal. This was to prevent overheating of fuel compacts due to higher than normal ATR power during the subsequent Powered Axial Locator Mechanism cycle, 153B. The AGR 3/4 test was inserted back into the ATR NEFT location during the outage of ATR Cycle 154A on April 26, 2013. Therefore, the AGR-3/4 irradiation data received during these 2 cycles (153A and 153B) are irrelevant and their qualification status isnot included in this report. Additionally, during ATR Cycle 152A the ATR core ran at low power for a short enough duration that the irradiation data are not used for physics and thermal calculations. However, the qualification status of irradiation data for this cycle is still covered in this report. As a result, this report includes data from 8 ATR Cycles: 151A, 151B, 152A, 152B, 154A, 154B, 155A, and 155B, as recorded in the Nuclear Data Management and

  12. Human papillomavirus detection using PCR and ATR-FTIR for cervical cancer screening

    Science.gov (United States)

    Rymsza, Taciana; Ribeiro, Eliane Aline; de Carvalho, Luis Felipe das Chagas e. Silva; Bhattacharjee, Tanmoy; de Azevedo Canevari, Renata

    2018-05-01

    The human papillomavirus (HPV) genital infection is considered one of the most common sexually transmitted diseases worldwide, and has been associated with cervical cancer. The objective of this study was to investigate the efficacy of the diagnostic methods: polymerase chain reaction (PCR) and Fourier transform infrared (FTIR) equipped with an ATR (Attenuated Total Reflectance) unit (Pike Tech) spectroscopy, to diagnose HPV infection in women undergoing gynecological examination. Seventeen patients (41.46%) of the 41 patients analyzed were diagnosed with exophytic/condyloma acuminate lesions by clinical analysis, 29 patients (70.7%) (G1 group) of the 41 patients, showed positive result for HPV cell injury by oncotic colpocitology and 12 patients (29.3%) (G2 group), presented negative result for cellular lesion and absence of clinical HPV lesion. Four samples were obtained per patient, which were submitted oncotic colpocitology analysis (Papanicolau staining, two samples), PCR (one sample) and ATR-FTIR analysis (one sample). L1 gene was amplified by PCR technique with specific GP5+/GP6+ and MY09/MY11 primers. PCR results were uniformly positive for presence of HPV in all analyzed samples. Multivariate analysis of ATR-FTIR spectra suggests no significant biochemical changes between groups and no clustering formed, concurring with results of PCR. This study suggests that PCR and ATR-FTIR are highly sensitive technique for HPV detection.

  13. "Radical" Feminists and "Bickering" Women: Backlash in U.S. Media Coverage of the United Nations Fourth World Conference on Women.

    Science.gov (United States)

    Danner, Lauren; Walsh, Susan

    1999-01-01

    Analyzes United States' newspaper coverage of the United Nations Fourth World Conference on Women for themes indicating backlash against feminism. Finds that several backlash themes, such as women in conflict and stereotypical portrayals of women, were present throughout the coverage. (CR)

  14. RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.

    Science.gov (United States)

    Lee, Yuan-Cho; Zhou, Qing; Chen, Junjie; Yuan, Jingsong

    2016-12-19

    ETAA1 (Ewing tumor-associated antigen 1), also known as ETAA16, was identified as a tumor-specific antigen in the Ewing family of tumors. However, the biological function of this protein remains unknown. Here, we report the identification of ETAA1 as a DNA replication stress response protein. ETAA1 specifically interacts with RPA (Replication protein A) via two conserved RPA-binding domains and is therefore recruited to stalled replication forks. Interestingly, further analysis of ETAA1 function revealed that ETAA1 participates in the activation of ATR signaling pathway via a conserved ATR-activating domain (AAD) located near its N terminus. Importantly, we demonstrate that both RPA binding and ATR activation are required for ETAA1 function at stalled replication forks to maintain genome stability. Therefore, our data suggest that ETAA1 is a new ATR activator involved in replication checkpoint control. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Analysis of the ATR fuel element swaging process

    International Nuclear Information System (INIS)

    Richins, W.D.; Miller, G.K.

    1995-12-01

    This report documents a detailed evaluation of the swaging process used to connect fuel plates to side plates in Advanced Test Reactor (ATR) fuel elements. The swaging is a mechanical process that begins with fitting a fuel plate into grooves in the side plates. Once a fuel plate is positioned, a lip on each of two side plate grooves is pressed into the fuel plate using swaging wheels to form the joints. Each connection must have a specified strength (measured in terms, of a pullout force capacity) to assure that these joints do not fail during reactor operation. The purpose of this study is to analyze the swaging process and associated procedural controls, and to provide recommendations to assure that the manufacturing process produces swaged connections that meet the minimum strength requirement. The current fuel element manufacturer, Babcock and Wilcox (B ampersand W) of Lynchburg, Virginia, follows established procedures that include quality inspections and process controls in swaging these connections. The procedures have been approved by Lockheed Martin Idaho Technologies and are designed to assure repeatability of the process and structural integrity of each joint. Prior to July 1994, ATR fuel elements were placed in the Hydraulic Test Facility (HTF) at the Idaho National Engineering Laboratory (AGNAIL), Test Reactor Area (TRA) for application of Boehmite (an aluminum oxide) film and for checking structural integrity before placement of the elements into the ATR. The results presented in this report demonstrate that the pullout strength of the swaged connections is assured by the current manufacturing process (with several recommended enhancements) without the need for- testing each element in the HTF

  16. The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication.

    Science.gov (United States)

    Edwards, Terri G; Bloom, David C; Fisher, Chris

    2018-03-15

    The ATM and Rad3-related (ATR) protein kinase and its downstream effector Chk1 are key sensors and organizers of the DNA damage response (DDR) to a variety of insults. Previous studies of herpes simplex virus 1 (HSV-1) showed no evidence for activation of the ATR pathway. Here we demonstrate that both Chk1 and ATR were phosphorylated by 3 h postinfection (h.p.i.). Activation of ATR and Chk1 was observed using 4 different HSV-1 strains in multiple cell types, while a specific ATR inhibitor blocked activation. Mechanistic studies point to early viral gene expression as a key trigger for ATR activation. Both pATR and pChk1 localized to the nucleus within viral replication centers, or associated with their periphery, by 3 h.p.i. Significant levels of pATR and pChk1 were also detected in the cytoplasm, where they colocalized with ICP4 and ICP0. Proximity ligation assays confirmed that pATR and pChk1 were closely and specifically associated with ICP4 and ICP0 in both the nucleus and cytoplasm by 3 h.p.i., but not with ICP8 or ICP27, presumably in a multiprotein complex. Chemically distinct ATR and Chk1 inhibitors blocked HSV-1 replication and infectious virion production, while inhibitors of ATM, Chk2, and DNA-dependent protein kinase (DNA-PK) did not. Together our data show that HSV-1 activates the ATR pathway at early stages of infection and that ATR and Chk1 kinase activities play important roles in HSV-1 replication fitness. These findings indicate that the ATR pathway may provide insight for therapeutic approaches. IMPORTANCE Viruses have evolved complex associations with cellular DNA damage response (DDR) pathways, which sense troublesome DNA structures formed during infection. The first evidence for activation of the ATR pathway by HSV-1 is presented. ATR is activated, and its downstream target Chk1 is robustly phosphorylated, during early stages of infection. Both activated proteins are found in the nucleus associated with viral replication compartments and in

  17. BCES: A Fifteen-Year Conference Tradition

    Directory of Open Access Journals (Sweden)

    Nikolay Popov

    2017-05-01

    Full Text Available This volume contains selected papers submitted to the XV Annual International Conference of the Bulgarian Comparative Education Society (BCES, held in June 2017 in Borovets, Bulgaria, and papers submitted to the V International Partner Conference of the International Research Centre (IRC ‘Scientific cooperation’, Rostov-on-Don, Russia, organized as part of the BCES Conference. The XV BCES Conference theme is Current Business and Economics Driven Discourse and Education: Perspectives from Around the World. The V International Partner Conference theme is Science and Education in Modern Social, Economic and Humanitarian Discourse. The book consists of 38 papers written by 69 authors. The volume starts with an introductory paper by Johannes L van der Walt. The other 37 papers are divided into 8 parts: 1 Comparative Education & History of Education; 2 Teacher Education; 3 Education Policy, Reforms & School Leadership; 4 Higher Education, Lifelong Learning & Social Inclusion; 5 Law and Education; 6 Research Education; 7 Educational Development Strategies in Different Countries and Regions of the World; 8 Key Directions and Characteristics of Research Organization in the Contemporary World.

  18. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014

    Energy Technology Data Exchange (ETDEWEB)

    Soelberg, Renae [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-11-01

    Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report November 2014 Highlights Rory Kennedy and Sarah Robertson attended the American Nuclear Society Winter Meeting and Nuclear Technology Expo in Anaheim, California, Nov. 10-13. ATR NSUF exhibited at the technology expo where hundreds of meeting participants had an opportunity to learn more about ATR NSUF. Dr. Kennedy briefed the Nuclear Engineering Department Heads Organization (NEDHO) on the workings of the ATR NSUF. • Rory Kennedy, James Cole and Dan Ogden participated in a reactor instrumentation discussion with Jean-Francois Villard and Christopher Destouches of CEA and several members of the INL staff. • ATR NSUF received approval from the NE-20 office to start planning the annual Users Meeting. The meeting will be held at INL, June 22-25. • Mike Worley, director of the Office of Innovative Nuclear Research (NE-42), visited INL Nov. 4-5. Milestones Completed • Recommendations for the Summer Rapid Turnaround Experiment awards were submitted to DOE-HQ Nov. 12 (Level 2 milestone due Nov. 30). Major Accomplishments/Activities • The University of California, Santa Barbara 2 experiment was unloaded from the GE-2000 at HFEF. The experiment specimen packs will be removed and shipped to ORNL for PIE. • The Terrani experiment, one of three FY 2014 new awards, was completed utilizing the Advanced Photon Source MRCAT beamline. The experiment investigated the chemical state of Ag and Pd in SiC shell of irradiated TRISO particles via X-ray Absorption Fine Structure (XAFS) spectroscopy. Upcoming Meetings/Events • The ATR NSUF program review meeting will be held Dec. 9-10 at L’Enfant Plaza. In addition to NSUF staff and users, NE-4, NE-5 and NE-7 representatives will attend the meeting. Awarded Research Projects Boise State University Rapid Turnaround Experiments (14-485 and 14-486) Nanoindentation and TEM work on the T91, HT9, HCM12A and 9Cr ODS specimens has been completed at

  19. To conference or not to conference

    African Journals Online (AJOL)

    can travel throughout the world, from Cape to Cairo, from Jakarta to. Istanbul, from San ... Is there any real advantage of going to conferences in the era of electronic ... to register and travel, and the time off work, are justified, although we are.

  20. Proceedings of the third USGS modeling conference, June 7-11, 2010, Broomfield, Colorado-Understanding and predicting for a changing world

    Science.gov (United States)

    Brady, Shailaja R.

    2011-01-01

    The Third USGS Modeling Conference was held June 7th-11, 2010, in Broomfield, Colorado. The conference focused on the development and application of analytical and theoretical models and data availability that support managing the Nation's resources and help protect lives and property. Participants at the conference included scientists and managers from Department of the Interior (DOI) Bureaus; national and international Federal, State, and local agencies; academic institutions; and nongovernmental organizations. The conference was organized according to DOI priorities and the strategic directions of the USGS Science Strategy; the following themes were emphasized: (1) Understanding Ecosystems and Restoring America's Treasured Landscapes; (2) Climate Change and Impact; (3) New Energy Frontier and Minerals for America; (4) A National Hazards, Risk, and Resilience Assessment Program; (5) Role of Environment and Wildlife in Human Health; (6) A Water Census of the United States; and (7) New Methods of Investigation and Discovery. The conference theme-"Understanding and Predicting for a Changing World"-focused on the following goals: advance development and application of models; provide tools that address management issues; present state-of-the-art models ranging from individual phenomena to integrated systems; and foster a working community among scientists and managers.

  1. Quantitative analysis of anti-inflammatory drugs using FTIR-ATR spectrometry

    Science.gov (United States)

    Hassib, Sonia T.; Hassan, Ghaneya S.; El-Zaher, Asmaa A.; Fouad, Marwa A.; Taha, Enas A.

    2017-11-01

    Four simple, accurate, sensitive and economic Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopic (ATR-FTIR) methods have been developed for the quantitative estimation of some non-steroidal anti-inflammatory drugs. The first method involves the determination of Etodolac by direct measurement of the absorbance at 1716 cm- 1. In the second method, the second derivative of the IR spectra of Tolfenamic acid and its reported degradation product (2-chlorobenzoic acid) was used and the amplitudes were measured at 1084.27 cm- 1 and 1056.02 cm- 1 for Tolfenamic acid and 2-chlorobenzoic acid, respectively. The third method used the first derivative of the IR spectra of Bumadizone and its reported degradation product, N,N-diphenylhydrazine and the amplitudes were measured at 2874.98 cm- 1 and 2160.32 cm- 1 for Bumadizone and N,N-diphenylhydrazine, respectively. The fourth method depends on measuring the amplitude of Diacerein at 1059.18 cm- 1 and of rhein, its reported degradation product, at 1079.32 cm- 1 in their first derivative spectra. The four methods were successfully applied on the pharmaceutical formulations by extracting the active constituent in chloroform and the extract was directly measured in liquid phase mode using a specific cell. Moreover, validation of these methods was carried out following International Conference of Harmonisation (ICH) guidelines.

  2. 2010 World bio-energy conference

    International Nuclear Information System (INIS)

    2010-01-01

    After having evoked the bio-energy price awarded to a Brazilian for his works on the use of eucalyptus as energy source, this report proposes a synthesis of the highlights of the conference: discussions about sustainability, bio-energies as an opportunity for developing countries, the success of bio-energies in Sweden, and more particularly some technological advances in the field of biofuels: a bio-LPG by Biofuel-solution AB, catalysis, bio-diesel from different products in a Swedish farm, a second generation ethanol by the Danish company Inbicon, a large scale methanization in Goteborg, a bio-refinery concept in Sweden, bio-gases

  3. Seeded growth fabrication of Cu-on-Si electrodes for in situ ATR-SEIRAS applications

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hui-Feng [Shanghai Key Laboratory for Molecular Catalysis and Innovative Materials and Department of Chemistry, Fudan University, Shanghai 200433 (China); Yan, Yan-Gang [Shanghai Key Laboratory for Molecular Catalysis and Innovative Materials and Department of Chemistry, Fudan University, Shanghai 200433 (China); Huo, Sheng-Juan [Shanghai Key Laboratory for Molecular Catalysis and Innovative Materials and Department of Chemistry, Fudan University, Shanghai 200433 (China); Cai, Wen-Bin [Shanghai Key Laboratory for Molecular Catalysis and Innovative Materials and Department of Chemistry, Fudan University, Shanghai 200433 (China); Department of Enviromental Engineering, Shanghai University of Electric Power, Shanghai 200090 (China); E-mail: wbcai@fudan.edu.cn; Xu, Qun-Jie [Department of Enviromental Engineering, Shanghai University of Electric Power, Shanghai 200090 (China); Osawa, Masatoshi [Catalysis Research Center, Hokkaido University, Sapporo 001-0021 (Japan)

    2007-05-25

    A seeded-growth approach has been developed to fabricate a Cu nanoparticle film (simplified hereafter with nanofilm) on Si for electrochemical ATR surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS). The approach comprises an initial activation of the reflecting plane of hemicylindrical Si prism by introducing a Cu seed layer in a CuSO{sub 4}-HF solution and the subsequent electroless deposition of the Cu nanofilms from an electroless Cu plating bath. The as-deposited Cu nanofilm exhibited strong SEIRA effect for the CO probe and interfacial free H{sub 2}O. ATR-SEIRAS was also applied to characterize the adsorbed geometries of pyridine at the Cu/electrolyte interface. Only vibrational bands assignable to the A {sub 1} symmetry modes were detected in the entire potential window investigated, suggestive of an end-on adsorption via the ring N-atom on a Cu electrode.

  4. Seeded growth fabrication of Cu-on-Si electrodes for in situ ATR-SEIRAS applications

    International Nuclear Information System (INIS)

    Wang, Hui-Feng; Yan, Yan-Gang; Huo, Sheng-Juan; Cai, Wen-Bin; Xu, Qun-Jie; Osawa, Masatoshi

    2007-01-01

    A seeded-growth approach has been developed to fabricate a Cu nanoparticle film (simplified hereafter with nanofilm) on Si for electrochemical ATR surface-enhanced infrared absorption spectroscopy (ATR-SEIRAS). The approach comprises an initial activation of the reflecting plane of hemicylindrical Si prism by introducing a Cu seed layer in a CuSO 4 -HF solution and the subsequent electroless deposition of the Cu nanofilms from an electroless Cu plating bath. The as-deposited Cu nanofilm exhibited strong SEIRA effect for the CO probe and interfacial free H 2 O. ATR-SEIRAS was also applied to characterize the adsorbed geometries of pyridine at the Cu/electrolyte interface. Only vibrational bands assignable to the A 1 symmetry modes were detected in the entire potential window investigated, suggestive of an end-on adsorption via the ring N-atom on a Cu electrode

  5. Volvulus and bowel obstruction in ATR-X syndrome-clinical report and review of literature.

    Science.gov (United States)

    Horesh, Nir; Pery, Ron; Amiel, Imri; Shwaartz, Chaya; Speter, Chen; Guranda, Larisa; Gutman, Mordechai; Hoffman, Aviad

    2015-11-01

    Alpha thalassemia-mental retardation, X-linked (ATR-X) syndrome is a rare genetic disorder with a variety of clinical manifestations. Gastrointestinal symptoms described in this syndrome include difficulties in feeding, regurgitation and vomiting which may lead to aspiration pneumonia, abdominal pain, distention, and constipation. We present a 19-year-old male diagnosed with ATR-X syndrome, who suffered from recurrent colonic volvulus that ultimately led to bowel necrosis with severe septic shock requiring emergent surgical intervention. During 1 year, the patient was readmitted four times due to poor oral intake, dehydration and abdominal distention. Investigation revealed partial small bowel volvulus which resolved with non-operative treatment. Small and large bowel volvulus are uncommon and life-threatening gastrointestinal manifestations of ATR-X patients, which may contribute to the common phenomenon of prolonged food refusal in these patients. © 2015 Wiley Periodicals, Inc.

  6. In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling.

    Science.gov (United States)

    Lindsey-Boltz, Laura A; Reardon, Joyce T; Wold, Marc S; Sancar, Aziz

    2012-10-19

    Replication protein A (RPA) plays essential roles in DNA metabolism, including replication, checkpoint, and repair. Recently, we described an in vitro system in which the phosphorylation of human Chk1 kinase by ATR (ataxia telangiectasia mutated and Rad3-related) is dependent on RPA bound to single-stranded DNA. Here, we report that phosphorylation of other ATR targets, p53 and Rad17, has the same requirements and that RPA is also phosphorylated in this system. At high p53 or Rad17 concentrations, RPA phosphorylation is inhibited and, in this system, RPA with phosphomimetic mutations cannot support ATR kinase function, whereas a non-phosphorylatable RPA mutant exhibits full activity. Phosphorylation of these ATR substrates depends on the recruitment of ATR and the substrates by RPA to the RPA-ssDNA complex. Finally, mutant RPAs lacking checkpoint function exhibit essentially normal activity in nucleotide excision repair, revealing RPA separation of function for checkpoint and excision repair.

  7. In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling*

    Science.gov (United States)

    Lindsey-Boltz, Laura A.; Reardon, Joyce T.; Wold, Marc S.; Sancar, Aziz

    2012-01-01

    Replication protein A (RPA) plays essential roles in DNA metabolism, including replication, checkpoint, and repair. Recently, we described an in vitro system in which the phosphorylation of human Chk1 kinase by ATR (ataxia telangiectasia mutated and Rad3-related) is dependent on RPA bound to single-stranded DNA. Here, we report that phosphorylation of other ATR targets, p53 and Rad17, has the same requirements and that RPA is also phosphorylated in this system. At high p53 or Rad17 concentrations, RPA phosphorylation is inhibited and, in this system, RPA with phosphomimetic mutations cannot support ATR kinase function, whereas a non-phosphorylatable RPA mutant exhibits full activity. Phosphorylation of these ATR substrates depends on the recruitment of ATR and the substrates by RPA to the RPA-ssDNA complex. Finally, mutant RPAs lacking checkpoint function exhibit essentially normal activity in nucleotide excision repair, revealing RPA separation of function for checkpoint and excision repair. PMID:22948311

  8. World Food Security and Insecurity, 1974-84.

    Science.gov (United States)

    Kriesberg, Martin

    In the decade since the World Food Conference of 1974, increased attention has been directed to the problems of world food security. The emphasis on technologies of production, while important, have not sufficed. Two major shortcomings of the World Food Conference and the efforts it stimulated were (1) the failure to recognize the relationship…

  9. Learning at a Distance. Report on the DSE Conference (West Berlin, Germany, June 2-7, 1982) in Connection with the World Conference of ICCE (12th, Vancouver, Canada, June 8-17, 1982).

    Science.gov (United States)

    German Foundation for International Development, Bonn (West Germany).

    Two international meetings on distance education are summarized in this report. The first, a preparatory seminar on "Staff Development for Distance Education," was held in Berlin to give African participants an opportunity to meet prior to attending the 12th World Conference of the International Council for Correspondence Education…

  10. [Relationship between PMI and ATR-FTIR Spectral Changes in Swine Costal Cartilages and Ribs].

    Science.gov (United States)

    Yao, Yao; Wang, Qi; Jing, Xiao-li; Li, Bing; Zhang, Yin-ming; Wang, Zhi-jun; Li, Cheng-zhi; Lin, Han-cheng; Zhang, Ji; Huang, Ping; Wang, Zhen-yuan

    2016-02-01

    To analyze postmortem chemical changes in Landrace costal cartilages and ribs using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, and to provide a novel technique for estimation of postmortem interval (PMI). The swines were sacrificed by hemorrhage and their costal cartilages and ribs were kept in 20 degrees C. The chemical analysis of the costal cartilages and ribs were performed using ATR-FTIR every 72 h. The correlation between the certain spectral parameters and PMI was also analyzed. The time-dependent changes of costal cartilages were more significant than ribs. There were no obvious changes for the main absorbance bands position, and some absorbance band ratios showed time-dependent changes and significant correlations with the PMI. ATR-FTIR has the ability to analyze postmortem chemical changes of the swine costal cartilages and ribs, and it can be a new method to estimate PMI based on spectroscopy.

  11. Stockholm conference. Summary of the international conference on the security of material in Stockholm, Sweden

    International Nuclear Information System (INIS)

    Hoskins, Richard

    2001-01-01

    Preventing illicit uses of nuclear material and radioactive sources was a major international concern even before the spectre of nuclear terrorism was raised by terrorist attacks in September 2001. At an IAEA international conference in Stockholm, Sweden, convened in May 2001, international experts examined ways and means of strengthening systems for the protection of nuclear and radioactive material. The Conference - formally called 'Security of Material: Measures to Prevent, Intercept and Respond to Illicit Uses of Nuclear Material and Radioactive Sources' - was attended by more than 300 experts from around the world. It was organized by the IAEA in cooperation with the European Police Office (Europol), the International Criminal Police Organization - Interpol (ICPO-Interpol), and the World Customs Organization (WCO), and hosted by the Swedish Nuclear Power Inspectorate. In the Conference Summary Document, participants underscored the importance of establishing stronger systems for nuclear security, and they outlined a number of steps for the future in particular areas. Following are excerpts from the Document. More information on the Conference is accessible on the IAEA's WorldAtom Web site at http://www.iaea.org/ worldatom/Press/P r elease/2001/ prn0110.shtml

  12. Analysis of H2O in silicate glass using attenuated total reflectance (ATR) micro-FTIR spectroscopy

    Science.gov (United States)

    Lowenstern, Jacob B.; Pitcher, Bradley W.

    2013-01-01

    We present a calibration for attenuated total reflectance (ATR) micro-FTIR for analysis of H2O in hydrous glass. A Ge ATR accessory was used to measure evanescent wave absorption by H2O within hydrous rhyolite and other standards. Absorbance at 3450 cm−1 (representing total H2O or H2Ot) and 1630 cm−1 (molecular H2O or H2Om) showed high correlation with measured H2O in the glasses as determined by transmission FTIR spectroscopy and manometry. For rhyolite, wt%H2O=245(±9)×A3450-0.22(±0.03) and wt%H2Om=235(±11)×A1630-0.20(±0.03) where A3450 and A1630 represent the ATR absorption at the relevant infrared wavelengths. The calibration permits determination of volatiles in singly polished glass samples with spot size down to ~5 μm (for H2O-rich samples) and detection limits of ~0.1 wt% H2O. Basaltic, basaltic andesite and dacitic glasses of known H2O concentrations fall along a density-adjusted calibration, indicating that ATR is relatively insensitive to glass composition, at least for calc-alkaline glasses. The following equation allows quantification of H2O in silicate glasses that range in composition from basalt to rhyolite: wt%H2O=(ω×A3450/ρ)+b where ω = 550 ± 21, b = −0.19 ± 0.03, ρ = density, in g/cm3, and A3450 is the ATR absorbance at 3450 cm−1. The ATR micro-FTIR technique is less sensitive than transmission FTIR, but requires only a singly polished sample for quantitative results, thus minimizing time for sample preparation. Compared with specular reflectance, it is more sensitive and better suited for imaging of H2O variations in heterogeneous samples such as melt inclusions. One drawback is that the technique can damage fragile samples and we therefore recommend mounting of unknowns in epoxy prior to polishing. Our calibration should hold for any Ge ATR crystals with the same incident angle (31°). Use of a different crystal type or geometry would require measurement of several H2O-bearing standards to provide a crystal

  13. Conference on Environmental Data Management

    CERN Document Server

    Oppenheimer, Dorothy; Brogden, William; Environmental Data Management

    1976-01-01

    Throughout the world a staggering amount of resources have been used to obtain billions of environmental data points. Some, such as meteorological data, have been organized for weather map display where many thousands of data points are synthesized in one compressed map. Most environmental data, however, are still widely scattered and generally not used for a systems approach, but only for the purpose for which they were originally taken. These data are contained in relatively small computer programs, research files, government and industrial reports, etc. This Conference was called to bring together some of the world's leaders from research centers and government agencies, and others concerned with environmental data management. The purpose of the Conference was to organize discussion on the scope of world environmental data, its present form and documentation, and whether a systematic approach to a total system is feasible now or in the future. This same subject permeated indirectly the Stockholm Conference...

  14. 7th World Conference on Mass Customization, Personalization, and Co-Creation

    CERN Document Server

    Nielsen, Kjeld; Joergensen, Kaj; Taps, Stig

    2014-01-01

    The MCPC 2014 is a multi‐track conference featuring a combination of high profile keynotes with expert talks, panel discussions, paper sessions, workshops, receptions, and much more. While it is devoted to sharing and discussing the latest research in the field, the MCPC conference has a strong focus on real life applications. Since its beginning, the MCPC conference has had an equal share of participants, practitioners and academics/researchers. This makes the MCPC conference truly unique among many conferences. It strives to connect MCPC thinkers, first movers, entrepreneurs, technology developers, and researchers with people applying these strategies in practice. Twenty years ago Mass Customization was acknowledged as the ”New Frontier in Business Competition”. Ever since, industry has been applying the concept and researchers have developed the topic into a well-established research area and businesses have formed new strategies. More knowledge, methods and technologies are available now than ever b...

  15. White Paper Report of the RAD-AID Conference on International Radiology for Developing Countries: identifying challenges, opportunities, and strategies for imaging services in the developing world.

    Science.gov (United States)

    Mollura, Daniel J; Azene, Ezana M; Starikovsky, Anna; Thelwell, Aduke; Iosifescu, Sarah; Kimble, Cary; Polin, Ann; Garra, Brian S; DeStigter, Kristen K; Short, Brad; Johnson, Benjamin; Welch, Christian; Walker, Ivy; White, David M; Javadi, Mehrbod S; Lungren, Matthew P; Zaheer, Atif; Goldberg, Barry B; Lewin, Jonathan S

    2010-07-01

    The RAD-AID Conference on International Radiology for Developing Countries was an assembly of individuals and organizations interested in improving access to medical imaging services in developing countries where the availability of radiology has been inadequate for both patient care and public health programs. The purpose of the meeting was to discuss data, experiences, and models pertaining to radiology in the developing world and to evaluate potential opportunities for future collaboration. Conference participants included radiologists, technologists, faculty members of academic medical institutions, and leadership of nongovernmental organizations involved in international health care and social entrepreneurship. Four main themes from the conference are presented in this white paper as important factors for the implementation and optimization of radiology in the developing world: (1) ensuring the economic sustainability of radiologic services through financial and administrative training support of health care personnel; (2) designing, testing, and deploying clinical strategies adapted for regions with limited resources; (3) structuring and improving the role of American radiology residents interested in global health service projects; and (4) implementing information technology models to support digital imaging in the developing world. Published by Elsevier Inc.

  16. World Biotechnology Leaders to Gather for Conference

    Science.gov (United States)

    Biotechnology Leaders to Gather for Conference For more information contact: e:mail: Public Affairs biotechnology leaders gather in Fort Collins, CO May 2-6 for the 21st Symposium on Biotechnology for Fuels and special session on funding opportunities for U.S. biotechnology projects. More than 175 presentations are

  17. ATR kinase regulates its attenuation via PPM1D phosphatase ...

    Indian Academy of Sciences (India)

    Debadrita Bhattacharya

    2018-02-07

    Feb 7, 2018 ... generated in response to ultraviolet and ionizing radiation (Lu et al. 2005a, b; Cha ... nocopy' each other's effects by uncovering persistent ATR signalling that in ...... been shown to indirectly stabilize PPM1D by mediating the.

  18. 10 CFR 830 Major Modification Determination for the ATR Diesel Bus (E-3) and Switchgear Replacement

    International Nuclear Information System (INIS)

    Duckwitz, Noel

    2011-01-01

    Near term replacement of aging and obsolescent original ATR equipment has become important to ensure ATR capability in support of NE's long term national missions. To that end, a mission needs statement has been prepared for a non-major system acquisition which is comprised of three interdependent subprojects. The first project, subject of this determination, will replace the existent diesel-electrical bus (E-3) and associated switchgear. More specifically, INL proposes transitioning ATR to 100% commercial power with appropriate emergency backup to include: (1) Provide commercial power as the normal source of power to the ATR loads currently supplied by diesel-electric power. (2) Provide backup power to the critical ATR loads in the event of a loss of commercial power. (3) Replace obsolescent critical ATR power distribution equipment, e.g., switchgear, transformers, motor control centers, distribution panels. Completion of this and two other age-related projects (primary coolant pump and motor replacement and emergency firewater injection system replacement) will resolve major age related operational issues plus make a significant contribution in sustaining the ATR safety and reliability profile. The major modification criteria evaluation of the project pre-conceptual design identified several issues make the project a major modification: (1) Evaluation Criteria No.2 (Footprint change). The addition of a new PC-4 structure to the ATR Facility to house safety-related SSCs requires careful attention to maintaining adherence to applicable engineering and nuclear safety design criteria (e.g., structural qualification, fire suppression) to ensure no adverse impacts to the safety-related functions of the housed equipment. (2) Evaluation Criteria No.3 (Change of existing process). The change to the strategy for providing continuous reliable power to the safety-related emergency coolant pumps requires careful attention and analysis to ensure it meets a project primary

  19. Trends in NDE science and technology: proceedings of the fourteenth world conference on NDT. V. 1

    International Nuclear Information System (INIS)

    Krishnadas Nair, C.G.; Baldev Raj; Murthy, C.R.L.; Jayakumar, T.

    1996-01-01

    The multi volume proceedings of the 14th World Conference on Nondestructive Testing (NDT) cover the applications of Nondestructive Evaluation (NDE) in a wide range of industries, viz. aerospace, chemical, defence, manufacturing, nuclear etc. and for different materials. The major topics covered under it are NDE in nuclear industry, NDE of tubes and bars, non destructive evaluation of composites, NDE of concrete, non destructive evaluation of stresses, NDE of defects, condition monitoring, vibration monitoring, life prediction and NDE for medical applications. Papers relevant to INIS from this volume are indexed separately

  20. Trends in NDE science and technology: proceedings of the fourteenth world conference on NDT. V. 3

    International Nuclear Information System (INIS)

    Krishnadas Nair, C.G.; Baldev Raj; Murthy, C.R.L.; Jayakumar, T.

    1996-01-01

    The multi volume proceedings of the 14th World Conference on Nondestructive Testing (NDT) cover the applications of Non destructive Evaluation (NDE) in a wide range of industries, viz. aerospace, chemical, defence, manufacturing, nuclear etc. and for different materials. The major topics covered under it are NDE in nuclear industry, NDE of tubes and bars, non destructive evaluation of composites, NDE of concrete, non destructive evaluation of stresses, NDE of defects, condition monitoring, vibration monitoring, life prediction and NDE for medical applications. Papers relevant to INIS from this volume are indexed separately

  1. Trends in NDE science and technology: proceedings of the fourteenth world conference on NDT. V. 2

    International Nuclear Information System (INIS)

    Krishnadas Nair, C.G.; Baldev Raj; Murthy, C.R.L.; Jayakumar, T.

    1996-01-01

    The multi volume proceedings of the 14th World Conference on Nondestructive Testing (NDT) cover the applications of Nondestructive Evaluation (NDE) in a wide range of industries, viz. aerospace, chemical, defence, manufacturing, nuclear etc. and for different materials. The major topics covered under it are NDE in nuclear industry, NDE of tubes and bars, non destructive evaluation of composites, NDE of concrete, non destructive evaluation of stresses, NDE of defects, condition monitoring, vibration monitoring, life prediction and NDE for medical applications. Papers relevant to INIS from this volume are indexed separately

  2. Trends in NDE science and technology: proceedings of the fourteenth world conference on NDT. V. 4

    International Nuclear Information System (INIS)

    Krishnadas Nair, C.G.; Baldev Raj; Murthy, C.R.L.; Jayakumar, T.

    1996-01-01

    The multi volume proceedings of the 14th World Conference on Nondestructive Testing (NDT) cover the applications of Nondestructive Evaluation (NDE) in a wide range of industries, viz. aerospace, chemical, defence, manufacturing, nuclear etc. and for different materials. The major topics covered under it are NDE in nuclear industry, NDE of tubes and bars, non destructive evaluation of composites, NDE of concrete, non destructive evaluation of stresses, NDE of defects, condition monitoring, vibration monitoring, life prediction and NDE for medical applications. Papers relevant to INIS from this volume are indexed separately

  3. Trends in NDE science and technology: proceedings of the fourteenth world conference on NDT V. 5

    International Nuclear Information System (INIS)

    Krishnadas Nair, C.J.; Baldev Raj; Murthy, C.R.L.; Jayakumar, T.

    1996-01-01

    The multi volume proceedings of the 14th World Conference on Nondestructive Testing (NDT) cover the applications of Nondestructive Evaluation (NDE) in a wide range of industries, viz. aerospace, chemical, defence, manufacturing, nuclear etc. and for different materials. The major topics covered under it are NDE in nuclear industry, NDE of tubes and bars, non destructive evaluation of composites, NDE of concrete, non destructive evaluation of stresses, NDE of defects, condition monitoring, vibration monitoring, life prediction and NDE for medical applications. Papers relevant to INIS from this volume are indexed separately

  4. Analysis of cosmetic residues on a single human hair by ATR FT-IR microspectroscopy.

    Science.gov (United States)

    Pienpinijtham, Prompong; Thammacharoen, Chuchaat; Naranitad, Suwimol; Ekgasit, Sanong

    2018-05-15

    In this work, ATR FT-IR spectra of single human hair and cosmetic residues on hair surface are successfully collected using a homemade dome-shaped Ge μIRE accessary installed on an infrared microscope. By collecting ATR spectra of hairs from the same person, the spectral patterns are identical and superimposed while different spectral features are observed from ATR spectra of hairs collected from different persons. The spectral differences depend on individual hair characteristics, chemical treatments, and cosmetics on hair surface. The "Contact-and-Collect" technique that transfers remarkable materials on the hair surface to the tip of the Ge μIRE enables an identification of cosmetics on a single hair. Moreover, the differences between un-split and split hairs are also studied in this report. These highly specific spectral features can be employed for unique identification or for differentiation of hairs based on the molecular structures of hairs and cosmetics on hairs. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Analysis of cosmetic residues on a single human hair by ATR FT-IR microspectroscopy

    Science.gov (United States)

    Pienpinijtham, Prompong; Thammacharoen, Chuchaat; Naranitad, Suwimol; Ekgasit, Sanong

    2018-05-01

    In this work, ATR FT-IR spectra of single human hair and cosmetic residues on hair surface are successfully collected using a homemade dome-shaped Ge μIRE accessary installed on an infrared microscope. By collecting ATR spectra of hairs from the same person, the spectral patterns are identical and superimposed while different spectral features are observed from ATR spectra of hairs collected from different persons. The spectral differences depend on individual hair characteristics, chemical treatments, and cosmetics on hair surface. The "Contact-and-Collect" technique that transfers remarkable materials on the hair surface to the tip of the Ge μIRE enables an identification of cosmetics on a single hair. Moreover, the differences between un-split and split hairs are also studied in this report. These highly specific spectral features can be employed for unique identification or for differentiation of hairs based on the molecular structures of hairs and cosmetics on hairs.

  6. Gauvain e il corpo smembrato: allegorie nell'«Atre périlleux»

    Directory of Open Access Journals (Sweden)

    Maurizio Virdis

    2013-07-01

    Full Text Available L’Atre Périlleux è un romanzo anonimo francese del XIII secolo e fa parte della corrente letteraria che rimettere in questione il romanzo cortese di tradizione chrestieniana. Piú che all’ideologia o alle istanze della classe cavalleresca e della nobiltà minore, il nostro romanzo risponde alle prospettive e alle necessità intellettuali della clergie, che si fa gioco dei valori cavallereschi tradizionali. L’Atre Périlleux è condotto, con toni di humour e una trama complessa, su binari metaletterari e allegorici (di cui il corpo smembrato di Gauvain è il simbolo piú eminente, e si pone come critica della decadenza della società cortese, animato però dal proposito del rinnovamento morale di essa.L’Atre Périlleux is an anonymous French romance of the thirteenth century and it is part of the literary movement that calls into question the tradition of courtly romance dating back to Chrétien de Troyes. More than to the ideology and instances of the class of minor nobility and chivalry, our romance responds to the clergie’s needs and intellectual perspectives, and it mocks the traditional values of chivalry. L’Atre Périlleux is conducted, with a hint of humour and a complicated plot, on metaliterary and allegorical tracks (and Gauvain’s dismembered body is the most prominent symbol of this allegorical tone, so that our romance stands as a critique of courtly society decadence, nevertheless animated by the purpose of its moral renewal.

  7. ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle.

    Science.gov (United States)

    Ray, Alo; Blevins, Chessica; Wani, Gulzar; Wani, Altaf A

    2016-01-01

    Cell cycle checkpoint is mediated by ATR and ATM kinases, as a prompt early response to a variety of DNA insults, and culminates in a highly orchestrated signal transduction cascade. Previously, we defined the regulatory role of nucleotide excision repair (NER) factors, DDB2 and XPC, in checkpoint and ATR/ATM-dependent repair pathway via ATR and ATM phosphorylation and recruitment to ultraviolet radiation (UVR)-induced damage sites. Here, we have dissected the molecular mechanisms of DDB2- and XPC- mediated regulation of ATR and ATM recruitment and activation upon UVR exposures. We show that the ATR and ATM activation and accumulation to UVR-induced damage not only depends on DDB2 and XPC, but also on the NER protein XPA, suggesting that the assembly of an active NER complex is essential for ATR and ATM recruitment. ATR and ATM localization and H2AX phosphorylation at the lesion sites occur as early as ten minutes in asynchronous as well as G1 arrested cells, showing that repair and checkpoint-mediated by ATR and ATM starts early upon UV irradiation. Moreover, our results demonstrated that ATR and ATM recruitment and H2AX phosphorylation are dependent on NER proteins in G1 phase, but not in S phase. We reasoned that in G1 the UVR-induced ssDNA gaps or processed ssDNA, and the bound NER complex promote ATR and ATM recruitment. In S phase, when the UV lesions result in stalled replication forks with long single-stranded DNA, ATR and ATM recruitment to these sites is regulated by different sets of proteins. Taken together, these results provide evidence that UVR-induced ATR and ATM recruitment and activation differ in G1 and S phases due to the existence of distinct types of DNA lesions, which promote assembly of different proteins involved in the process of DNA repair and checkpoint activation.

  8. The 9. European nuclear conference; La 9. conference nucleaire europeenne

    Energy Technology Data Exchange (ETDEWEB)

    Maurel, V.; Lewis, D.; Smirnov, V.P.; Gutierrez, J.E.; Paulin, Ph.; Markov, D.V.; Smirnov, A.V.; Polenok, V.S.; Horhoianu, G.; Olteanu, G.; Van der Schaaf, B.; Gavillet, D.; Lapena, J.; Ohms, C.; Roth, A.; Van Dyck, St.; Mardon, J.P.; Thomas, A.; Cipiere, M.F.; Faidy, C.; Hedin, F.; Delnondedieu, M.; Chassignole, B.; Doudet, L.; Dupond, O.; Kang, K.; Park, K.; Kim, K.; Ha, J.; Hoon-Seok, Jung; Yong-koo, Lee; Kwang-Ho, Kim; Seungwoo, Paek; Heui-Joo, Choi; Do-Hee, Ahn; Kwang-Rag, Kim; Minsoo, Lee; Sung-Paal, Yim; Hongsuk, Chung; Detroux, P.; Meessen, O.; Defloor, J.; Lars-Erik, Holm; Barescut, J.C.; Vacquier, B.; Laurier, D.; Caer, S.; Quesne, B.; Oudalova, A.; Geras' kin, St.; Dikarev, V.; Dikareva, N.; Chernonog, E.; Yang-Geun, Chung; Gab-Bock, Lee; Sun-Young, Bang; Yong-Sun, Lee; Bolognese-Milsztajn, T.; Frank, D.; Lacoste, V.; Pihet, P.; Lacronique, J.F.; Chauliac, C.; Verwaerde, D.; Pavageau, O.; Zaetta, A.; Varaine, F.; Warin, D.; Hudelot, J.P.; Bioux, Ph.; Klann, R.; Petruzzi, A.; D' auria, F.; Yung Kwon, Jin; Chul Jin, Chol; Mihalache, M.; Radu, V.; Pavelescu, M.; Schneidesch, Ch.R.; Jinzhao, Zhang; Dalleur, J.P.; Nuttin, A.; Meplan, O.; Wilson, J.; Perdu, F.; Campioni, G.; Mounier, C.; Sigrist, J.F.; Laine, Ch.; Broc, D.; Robbe, M.F.; Cariou, Y.; Seok-Kyun, Yoon; Win, Naing; Myung-Hyun, Kim; Kyung, Hee; Fridman, E.; Shwageraus, E.; Galperin, A.; Meplan, O.; Laulan, O.; Mechel-Sendis, F.; Belgaid, M.; Kadem, F.; Amokrane, A.; Hamidouche, T.; El-Khider, Si-Ahmed

    2005-11-15

    This issue gathers the abstracts of the papers presented at the ninth European nuclear conference (ENC-2005). The main part of the conference is split into 20 sessions. These sessions cover all technical aspects of nuclear power, from reactor design to waste management, without forgetting experimental and research reactors, reactor dismantling, economy, resources, safety, radioprotection and education issues. Perspectives of a nuclear renaissance are clearly visible in the world. This renaissance, mainly due to political, economical, societal and ecological factors, is fuelled by scientific and technical progress. This conference was the opportunity to present together these aspects of nuclear power and to analyze their mutual interactions.

  9. XVth World Conference of the International Union for Health Promotion and Education, Makuhari, Japan, 20-25 August 1995. Conference report.

    Science.gov (United States)

    Westaway, M S

    1995-09-01

    This article briefly highlights information provided by speakers at the World Conference of the International Union for Health Promotion and Education. The conference took place during August 1995, in Makuhari, Japan. One paper focused on health education in Japan, which would not be suitable for health promotion efforts in South Africa. Another paper focused on intersectoral efforts for health, policy, and networking. This paper addressed an issue important for all countries; the need for better communication among people working in health fields and improved outreach. A paper focusing on strengthening community action was presented. South Africa, as well as Japan, must work to involve communities in health service management. The author found that the paper on policy, practice, and research for health promotion and education was relevant to South Africa. Policymakers and practitioners tend to rely on precedence, intuition, personal experience, and political experience. Academic research funding does not support research that is relevant to policymakers and practitioners. The papers on healthy cities research were stimulating and had practical input. The proposed model involved a 3-phase and 14-step process of choosing a topic for an intervention, analyzing the intervention's political environment, and planning the political aspects of intervention. Another model of intersectoral action was spiral shaped and centered problem definition, direction setting, and structuring between networking and interorganizational relations. Four papers from Botswana focused on reproductive health. Other papers focused on teenage pregnancy.

  10. Threats, protests greet conference.

    Science.gov (United States)

    Struck, D

    1994-09-04

    In preparation for the 1994 International Conference on Population and Development, Egypt has deployed 14,000 police to protect participants from threatened violence. The Vatican has joined forces with Muslim fundamentalists to condemn the conference as a vehicle for imposing Western ideals, particularly abortion, on Third world countries. In addition, the opposition is raising the specter of a descent of homosexuals onto Cairo and Muslim fundamentalists have threatened to murder Western representatives. A suit filed by Islamic lawyers, aimed at stopping the conference, failed. Sudan and Saudi Arabia plan to boycott the conference, and it remains uncertain whether Libya will be represented. Conference organizers have not been deterred by the threats and note that the controversy has drawn public attention to the central issues under debate.

  11. Application of PSA level 1 for the Fugen prototype ATR plant

    International Nuclear Information System (INIS)

    Ikeda, H.; Iguchi, Y.; Sotsu, M.; Seki, O.; Satou, S.

    1997-01-01

    This paper presents application of PSA Level-1 for Prototype Advanced Thermal Reactor Plant ''Fugen'' in consideration of the design characteristics of such reactor and verify the safety aspect of Fugen using thus established procedure, ATR resembles the boiling water reactor (BWR) in a number of points, but there are also some differences between the ATR and the BWR. Therefore. PSA procedure have been established by taking such difference into consideration and by referring to experience of PSA in USA and Japan. Moreover, the core damage frequency was calculated on Fugen by using thus established procedure. As a result, it was verified that results including the maximum value of the uncertainty estimation were found to be quite satisfactory against the target value of reactor damage frequency defined by the International Atomic Energy Agency (IAEA). (author)

  12. International Conference SES 2006. Secure Energy Supply

    International Nuclear Information System (INIS)

    2006-01-01

    The International Conference SES 2006 (Secure Energy Supply, Bezpecna dodavka energie) was realised in Bratislava, during September 26 - 29, 2006 in the hotel Crowne Plaza and deals with most important problems of world and Slovak energetics. In work of Conference took part 108 slovak and 33 foreign participant from 11 countries of the world. Negotiations were realised in five sessions. First two days were devoted to lectures and second two days were visits of selected slovak energetic equipment. On the Conference has resounded matter of fact, that secure energy supply is extremely important subject for economy, but also for population

  13. Program of the Conference

    International Nuclear Information System (INIS)

    2006-01-01

    The International Conference SES 2006 (Secure Energy Supply, Bezpecna dodavka energie) was realised in Bratislava, during September 26 - 29, 2006 in the hotel Crowne Plaza and deals with most important problems of world and Slovak energetics. Objective of this Conference was discussion of experience and information concerning strategic aspects of energy supply safety and the development of the Slovak and European Energy Industry

  14. Measured Thermal and Fast Neutron Fluence Rates for ATF-1 Holders During ATR Cycle 157D

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-03-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 157D which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains measurements of the fluence rates corresponding to the particular elevations relative to the 80-ft. core elevation. The data in this report consist of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, and (3) plots of both the thermal and fast neutron fluence rates. The fluence rates reported are for the average power levels given in the table of power history and distribution.

  15. Conference handbook. Seventh Conference on Nuclear Science and Engineering in Australia

    International Nuclear Information System (INIS)

    2007-01-01

    The Australian Nuclear Association (ANA) inaugurated a series of biennial national conferences in 1995 to be held in alternate years to the series of international Pacific Basin Nuclear Conferences, of which the ANA hosted the Ninth in the series in Sydney in May 1994 and the Fifteenth in Sydney in 2006. The main objective of these national conferences is to present information on important aspects of the peaceful uses of nuclear science and engineering in Australia and to place this information in a world context and in a readily understood form. These conferences have the general title of Nuclear Science and Engineering in Australia and have consisted mainly of papers invited from leading experts in areas of topical interest in nuclear science and technology supported by contributed poster papers. This seventh conference in 2007 has the special theme A Nuclear Future and also includes papers by invited speakers and contributed posters

  16. In situ detection of cancerous kidney tissue by means of fiber ATR-FTIR spectroscopy

    Science.gov (United States)

    Sablinskas, Valdas; Velicka, Martynas; Pucetaite, Milda; Urboniene, Vidita; Ceponkus, Justinas; Bandzeviciute, Rimante; Jankevicius, Feliksas; Sakharova, Tatiana; Bibikova, Olga; Steiner, Gerald

    2018-02-01

    The crucial goal of kidney-sparing surgical resection of a malignant tumor is complete removal of the cancerous tissue. The exact border between the cancerous and normal tissues is not always possible to identify by naked eye, therefore, a supplementary intraoperative diagnosis is needed. Unfortunately, intraoperative pathology methods used nowadays are time consuming and of inadequate quality rendering not definitive diagnosis. It has recently been shown that ATR-FTIR spectroscopy can be used for fast discrimination between cancerous and normal kidney tissues by analyzing the collected spectra of the tissue touch imprint smears. Most prominent differences are obtained in the wavenumber region from 950 cm-1 to 1250 cm-1, where the spectral bands due to the molecular vibrations of glycogen arise in the spectra of cancerous tissue smears. Such method of detection of cancerous tissue is limited by requirement to transfer the suspected tissue from the body to the FTIR instrument and stamp it on an ATR crystal of the spectrometer. We propose a spectroscopic tool which exploits the same principle of detection of cancerous cells as mentioned above, but does not require the tissue to be transferred from the body to the spectrometer. The portable spectrometer used in this design is equipped with fiber ATR probe and a sensitive liquid nitrogen cooled MCT detector. The design of the fiber probe allows the ATR tip to be changed easily in order to use only new sterilized tips for each measurement point of the tissue. It also enables sampling multiple areas of the suspected tissue with high lateral resolution which, in turn, increases accuracy with which the marginal regions between normal and cancerous tissues can be identified. Due to the loss of optical signal in the fiber probe the spectra have lower signal-to-noise ratio than in the case of standard ATR sampling setup. However, software for the spectral analysis used with the fiber probe design is still able to distinguish

  17. Neutron radiography at the HFR Petten compilation of HFR Petten contributions to the second world conference on neutron radiography

    International Nuclear Information System (INIS)

    Markgraf, J.W.F.

    1986-01-01

    This booklet summarizes the six papers on neutron radiography activities at the Petten High Flux Reactor (HFR), presented at the Second World Conference on neutron radiography, held in June 1986 in Paris, France. The conference was organized by the French CEA and COFREND, and JRC Petten, HFR Division, with joint sponsorship of the national societies on Non-Destructive Testing (NDT) from the Federal Republic of Germany, United Kingdom, Japan and the United States. The Petten papers are concerned with: (i) the work of the Neutron Radiography Working Group (NRWG), an expert group operating under the auspices of the Commission of the European Communities represented by JRC Petten, HFR Division; (ii) applications of neutron radiography in research programmes performed at HFR; (iii) neutron radiography facilities at HFR; and (iv) image evaluation techniques

  18. Achieving safety/risk goals for less ATR backup power upgrades

    International Nuclear Information System (INIS)

    Atkinson, S.A.

    1995-01-01

    The Advanced Test Reactor probabilistic risk assessment for internal fire and flood events defined a relatively high risk for a total loss of electric power possibly leading to core damage. Backup power sources were disabled due to fire and flooding in the diesel generator area with propagation of the flooding to a common switchgear room. The ATR risk assessment was employed to define options for relocation of backup power system components to achieve needed risk reduction while minimizing costs. The risk evaluations were performed using sensitivity studies and importance measures. The risk-based evaluations of relocation options for backup power systems saved over $3 million from what might have been otherwise considered open-quotes necessaryclose quotes for safety/risk improvement. The ATR experience shows that the advantages of a good risk assessment are to define risk significance, risk specifics, and risk solutions which enable risk goals to be achieved at the lowest cost

  19. Diamond-coated ATR prism for infrared absorption spectroscopy of surface-modified diamond nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Remes, Z., E-mail: remes@fzu.cz [Institute of Physics of the ASCR, v.v.i., Cukrovarnicka 10, Praha 6 (Czech Republic); Kozak, H.; Rezek, B.; Ukraintsev, E.; Babchenko, O.; Kromka, A. [Institute of Physics of the ASCR, v.v.i., Cukrovarnicka 10, Praha 6 (Czech Republic); Girard, H.A.; Arnault, J.-C.; Bergonzo, P. [CEA, LIST, Diamond Sensors Laboratory, F-91191 Gif-sur-Yvette (France)

    2013-04-01

    Linear antenna microwave chemical vapor deposition process was used to homogeneously coat a 7 cm long silicon prism by 85 nm thin nanocrystalline diamond (NCD) layer. To show the advantages of the NCD-coated prism for attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) of nanoparticles, we apply diamond nanoparticles (DNPs) of 5 nm nominal size with various surface modifications by a drop-casting of their methanol dispersions. ATR-FTIR spectra of as-received, air-annealed, plasma-oxidized, and plasma-hydrogenated DNPs were measured in the 4000–1500 cm{sup −1} spectral range. The spectra show high spectral resolution, high sensitivity to specific DNP surface moieties, and repeatability. The NCD coating provides mechanical protection against scratching and chemical stability of the surface. Moreover, unlike on bare Si surface, NCD hydrophilic properties enable optically homogeneous coverage by DNPs with some aggregation on submicron scale as evidenced by scanning electron microscopy and atomic force microscopy. Compared to transmission FTIR regime with KBr pellets, direct and uniform deposition of DNPs on NCD-ATR prism significantly simplifies and speeds up the analysis (from days to minutes). We discuss prospects for in situ monitoring of surface modifications and molecular grafting.

  20. Diamond-coated ATR prism for infrared absorption spectroscopy of surface-modified diamond nanoparticles

    Science.gov (United States)

    Remes, Z.; Kozak, H.; Rezek, B.; Ukraintsev, E.; Babchenko, O.; Kromka, A.; Girard, H. A.; Arnault, J.-C.; Bergonzo, P.

    2013-04-01

    Linear antenna microwave chemical vapor deposition process was used to homogeneously coat a 7 cm long silicon prism by 85 nm thin nanocrystalline diamond (NCD) layer. To show the advantages of the NCD-coated prism for attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) of nanoparticles, we apply diamond nanoparticles (DNPs) of 5 nm nominal size with various surface modifications by a drop-casting of their methanol dispersions. ATR-FTIR spectra of as-received, air-annealed, plasma-oxidized, and plasma-hydrogenated DNPs were measured in the 4000-1500 cm-1 spectral range. The spectra show high spectral resolution, high sensitivity to specific DNP surface moieties, and repeatability. The NCD coating provides mechanical protection against scratching and chemical stability of the surface. Moreover, unlike on bare Si surface, NCD hydrophilic properties enable optically homogeneous coverage by DNPs with some aggregation on submicron scale as evidenced by scanning electron microscopy and atomic force microscopy. Compared to transmission FTIR regime with KBr pellets, direct and uniform deposition of DNPs on NCD-ATR prism significantly simplifies and speeds up the analysis (from days to minutes). We discuss prospects for in situ monitoring of surface modifications and molecular grafting.

  1. News Conference: Physics brings the community together Training: CERN trains physics teachers Education: World conference fosters physics collaborations Lecture: Physics education live at ASE Prize: Physics teacher wins first Moore medal Festival: European presidents patronize Science on Stage festival Videoconference: Videoconference brings Durban closer to the classroom

    Science.gov (United States)

    2012-03-01

    Conference: Physics brings the community together Training: CERN trains physics teachers Education: World conference fosters physics collaborations Lecture: Physics education live at ASE Prize: Physics teacher wins first Moore medal Festival: European presidents patronize Science on Stage festival Videoconference: Videoconference brings Durban closer to the classroom

  2. In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells.

    Science.gov (United States)

    Wang, Ming; Liu, Gang; Shan, Guo-Ping; Wang, Bing-Bing

    2017-08-01

    The study investigated the ability of ataxia-telangiectasia mutated (ATM)/Rad3-related (ATR) signaling pathway to influence the proliferation, apoptosis, and radiosensitivity of nasopharyngeal carcinoma (NPC) cells. NPC tissues and corresponding adjacent normal tissues were collected from 143 NPC patients. The NPC CNE2 cells were assigned into a control group, X-ray group, CGK-733 group, and X-ray+CGK-733 group. The mRNA levels of ATM and ATR were evaluated using quantitative real-time polymerase chain reaction (qRT-PCR) and the protein levels of ATM and ATR using western blotting. The positive expression of ATM and ATR in tissues and nude mouse tumor tissues was determined by immunohistochemistry. Cell proliferation, migration, invasion, and apoptosis rates were analyzed by the 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT) assay, scratch test, transwell assay, and flow cytometry, respectively. A nude mouse model of NPC was established to observe tumor volume and growth. The mRNA levels of ATR and ATM and the expression of ATR and ATM protein in NPC tissues were significantly higher than those in adjacent normal tissues. The colony formation assay showed that the colony-forming rate decreased, showing radiation dose-dependent and CGK-733 concentration-dependent manners. Expression of ATM, ATR, Chk1, and Chk2 was evidently increased in the X-ray, CGK-733, and X-ray+CGK-733groups compared with the control group, and the aforementioned expression was highest in the X-ray+CGK-733 group among the four groups. The cell proliferation, invasion, and migration were decreased, tumor volume decreased and cell apoptosis increased in the X-ray, CGK-733, and X-ray+CGK-733 groups compared with the control group; the X-ray+CGK-733 group exhibited lowest cell proliferation, invasion and migration, smallest tumor volume, and highest cell apoptosis among the four groups. Inhibition of ATM/ATR signaling pathway reduces proliferation and enhances apoptosis and

  3. 30 CFR 75.209 - Automated Temporary Roof Support (ATRS) systems.

    Science.gov (United States)

    2010-07-01

    ... of temporary support shall be used, as specified in the roof control plan, when— (1) Mining... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Automated Temporary Roof Support (ATRS) systems... COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Roof Support § 75.209...

  4. Educating on a Human Scale: Visions for a Sustainable World. Proceedings of the Human Scale Education Conference (Oxford, England, September 26, 1998).

    Science.gov (United States)

    Carnie, Fiona, Ed.

    Human Scale Education's 1998 conference addressed the creation of schools and learning experiences to foster in young people the attitudes and skills to shape a fairer and more sustainable world. "Values and Vision in Business and Education" (Anita Roddick) argues that educational curricula must contain the language and action of social…

  5. 18{sup th} world hydrogen energy conference 2010 (WHEC 2010). Proceedings. Speeches and plenary talks

    Energy Technology Data Exchange (ETDEWEB)

    Stolten, Detlef; Emonts, Bernd [eds.

    2012-07-03

    A comprehensive and renowned conference offers the opportunity to extend the scope beyond mere technical issues. It allows for having strategic presentations and discussing aspects of market introduction, industrial and Governmental target setting as well as approaches to and actions for implementation. The 18th World Hydrogen Conference 2010, WHEC2010, succeeded in exploiting this opportunity and satisfied the expectations. Strong political support in Germany and in the State of North Rhine Westphalia in particular made it possible to have high profile decision makers at the conference presenting their strategies first hand. Hence, a full day was dedicated to plenary speeches and overview talks. The WHEC2010 came handy at a time when fuel cells are developed to suit the requirements for vehicles, except for cost and durability. At a time when the competition with batteries and whether or how a hydrogen infrastructure can be established and afforded were hot topics in the public debate, which needed answers on a well informed basis. Considering fuel cells and hydrogen at a time at one conference and supplementing it with the current knowledge on batteries and hybridization clarity on the future role of these technologies was gained. Very likely fuel cells and batteries will coexist in a future of electrified vehicular transport. Their different technical characteristics will open the doors to different market segments. Implementing hydrogen infrastructure, being a requirement for fuel cells in transport, is considered doable and affordable. This book presents the speeches and overview papers from the plenary session of the WHEC2010 on May 17, 2010. Six further books of this issue contain the papers of the oral and poster presentations, except for the introductory talks of the sessions. The latter are published separately by Wiley in a book named Hydrogen and Fuel Cells. In total the 18th WHEC is documented on over 3800 pages in a structured way in order to reach

  6. International conference “Intellectuals and the First World War: Central European Perspective” (Kraków, Poland, 20–22 Oct., 2016

    Directory of Open Access Journals (Sweden)

    Tomasz Pudłocki

    2017-12-01

    Full Text Available “Intellectuals and the First World War: Central European Perspective”, a conference organized on October 20–22, 2016 in Kraków, was a perfect opportunity to discuss the phenomenon of the 1914–1918 conflict and its impact on the lives of intellectuals and the creators of culture. Many important scientific studies or cultural activities were interrupted by the war as a result of the conscription of the intellectuals and their death either on the WW1 fronts or as civilian victims. On the other hand, the war was also an opportunity for many to redirect professional careers in new directions e.g. in the service of military propaganda. The conference was organized by the Institute of History of the Jagiellonian University with the financial support of the Kraków City Council – City of Kraków. The conference brought together nearly 30 speakers from the European Union and the United States of America.

  7. Mutation analysis and characterization of ATR sequence variants in breast cancer cases from high-risk French Canadian breast/ovarian cancer families

    Directory of Open Access Journals (Sweden)

    Pichette Roxane

    2006-09-01

    Full Text Available Abstract Background Ataxia telangiectasia-mutated and Rad3-related (ATR is a member of the PIK-related family which plays, along with ATM, a central role in cell-cycle regulation. ATR has been shown to phosphorylate several tumor suppressors like BRCA1, CHEK1 and TP53. ATR appears as a good candidate breast cancer susceptibility gene and the current study was designed to screen for ATR germline mutations potentially involved in breast cancer predisposition. Methods ATR direct sequencing was performed using a fluorescent method while widely available programs were used for linkage disequilibrium (LD, haplotype analyses, and tagging SNP (tSNP identification. Expression analyses were carried out using real-time PCR. Results The complete sequence of all exons and flanking intronic sequences were analyzed in DNA samples from 54 individuals affected with breast cancer from non-BRCA1/2 high-risk French Canadian breast/ovarian families. Although no germline mutation has been identified in the coding region, we identified 41 sequence variants, including 16 coding variants, 3 of which are not reported in public databases. SNP haplotypes were established and tSNPs were identified in 73 healthy unrelated French Canadians, providing a valuable tool for further association studies involving the ATR gene, using large cohorts. Our analyses led to the identification of two novel alternative splice transcripts. In contrast to the transcript generated by an alternative splicing site in the intron 41, the one resulting from a deletion of 121 nucleotides in exon 33 is widely expressed, at significant but relatively low levels, in both normal and tumoral cells including normal breast and ovarian tissue. Conclusion Although no deleterious mutations were identified in the ATR gene, the current study provides an haplotype analysis of the ATR gene polymorphisms, which allowed the identification of a set of SNPs that could be used as tSNPs for large-scale association

  8. Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer

    International Nuclear Information System (INIS)

    Carlucci, Giuseppe; Carney, Brandon; Sadique, Ahmad; Vansteene, Axel; Tang, Jun; Reiner, Thomas

    2017-01-01

    Rationale: Ataxia telangiectasia and Rad3-related (ATR) threonine serine kinase is one of the key elements in orchestrating the DNA damage response (DDR). As such, inhibition of ATR can amplify the effects of chemo- and radiation-therapy, and several ATR inhibitors (ATRi) have already undergone clinical testing in cancer. For more accurate patient selection, monitoring and staging, real-time in vivo imaging of ATR could be invaluable; the development of appropriate imaging agents has remained a major challenge. Methods: 3-amino-N-(4-[ 18 F]phenyl)-6-(4-(methylsulfonyl)phenyl) pyrazine-2-carboxamide ([ 18 F]-ATRi), a close analogue of Ve-821, (a clinical ATRi candidate), was readily accomplished similarly to already established synthetic procedures. Structurally, 18 F was introduced at the 4-position of the aromatic ring of Ve-821 for generating a labeled ATR inhibitor. In vitro experiments were conducted in U251 MG glioblastoma cell lines and ex vivo biodistribution were performed in subcutaneous U251 MG xenograft bearing athymic nude mice following microPET imaging. Results: [ 18 F]-ATRi has a similar pharmacokinetic profile to that of Ve-821. Using an U251 MG glioblastoma mouse model, we evaluated the in vivo binding efficiency of [ 18 F]-ATRi. Blood and tumor showed a statistically significant difference between mice injected with only the probe or following blocking experiment with Ve-821 (1.48 ± 0.40%ID/g vs. 0.46 ± 0.12%ID/g in tumor and 1.85 ± 0.47%ID/g vs. 0.84 ± 0.3%ID/g in blood respectively). Conclusions: [ 18 F]-ATRi represents the first 18 F positron emission tomography (PET) ATR imaging agent, and is designed on a low nanomolar and clinically relevant ATR inhibitor.

  9. EDITORIAL: International MEMS Conference 2006

    Science.gov (United States)

    Tay, Francis E. H.; Jianmin, Miao; Iliescu, Ciprian

    2006-04-01

    The International MEMS conference (iMEMS2006) organized by the Institute of Bioengineering and Nanotechnology and Nanyang Technological University aims to provide a platform for academicians, professionals and industrialists in various related fields from all over the world to share and learn from each other. Of great interest is the incorporation of the theme of life sciences application using MEMS. It is the desire of this conference to initiate collaboration and form network of cooperation. This has continued to be the objective of iMEMS since its inception in 1997. The technological advance of MEMS over the past few decades has been truly exciting in terms of development and applications. In order to participate in this rapid development, a conference involving delegates from within the MEMS community and outside the community is very meaningful and timely. With the receipt of over 200 articles, delegates related to MEMS field from all over the world will share their perspectives on topics such as MEMS/MST Design, MEMS Teaching and Education, MEMS/MST Packaging, MEMS/MST Fabrication, Microsystems Applications, System Integration, Wearable Devices, MEMSWear and BioMEMS. Invited speakers and delegates from outside the field have also been involved to provide challenges, especially in the life sciences field, for the MEMS community to potentially address. The proceedings of the conference will be published as an issue in the online Journal of Physics: Conference Series and this can reach a wider audience and will facilitate the reference and citation of the work presented in the conference. We wish to express our deep gratitude to the International Scientific Committee members and the organizing committee members for contributing to the success of this conference. We would like to thank all the delegates, speakers and sponsors from all over the world for presenting and sharing their perspectives on topics related to MEMS and the challenges that MEMS can

  10. Hands That Shape the World: Report on the Conditions of Immigrant Women in the U.S. Five Years after the Beijing Conference.

    Science.gov (United States)

    National Network for Immigrant and Refugee Rights, Oakland, CA.

    This report details the challenges that immigrant women in the United States have faced since the 1995 United Nations World Conference on Women in Beijing, China. It presents a compilation of research and synthesis by immigrants' rights activists and organizations. Data come from immigrant women's testimony. The following topics are featured:…

  11. ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing's syndrome.

    Science.gov (United States)

    Langlois, Daniel K; Fritz, Michele C; Schall, William D; Bari Olivier, N; Smedley, Rebecca C; Pearson, Paul G; Bailie, Marc B; Hunt, Stephen W

    2018-05-02

    Cushing's syndrome in humans shares many similarities with its counterpart in dogs in terms of etiology (pituitary versus adrenal causes), clinical signs, and pathophysiologic sequelae. In both species, treatment of pituitary- and adrenal-dependent disease is met with limitations. ATR-101, a selective inhibitor of ACAT1 (acyl coenzyme A:cholesterol acyltransferase 1), is a novel small molecule therapeutic currently in clinical development for the treatment of adrenocortical carcinoma, congenital adrenal hyperplasia, and Cushing's syndrome in humans. Previous studies in healthy dogs have shown that ATR-101 treatment led to rapid, dose-dependent decreases in adrenocorticotropic hormone (ACTH) stimulated cortisol levels. The purpose of this clinical study was to investigate the effects of ATR-101 in dogs with Cushing's syndrome. ATR-101 pharmacokinetics and activity were assessed in 10 dogs with naturally-occurring Cushing's syndrome, including 7 dogs with pituitary-dependent disease and 3 dogs with adrenal-dependent disease. ATR-101 was administered at 3 mg/kg PO once daily for one week, followed by 30 mg/kg PO once daily for one (n = 4) or three (n = 6) weeks. Clinical, biochemical, adrenal hormonal, and pharmacokinetic data were obtained weekly for study duration. ATR-101 exposure increased with increasing dose. ACTH-stimulated cortisol concentrations, the primary endpoint for the study, were significantly decreased with responders (9 of 10 dogs) experiencing a mean ± standard deviation reduction in cortisol levels of 50 ± 17% at study completion. Decreases in pre-ACTH-stimulated cortisol concentrations were observed in some dogs although overall changes in pre-ACTH cortisol concentrations were not significant. The compound was well-tolerated and no serious drug-related adverse effects were reported. This study highlights the potential utility of naturally occurring canine Cushing's syndrome as a model for human disease and provides proof of

  12. Open source tools for ATR development and performance evaluation

    Science.gov (United States)

    Baumann, James M.; Dilsavor, Ronald L.; Stubbles, James; Mossing, John C.

    2002-07-01

    Early in almost every engineering project, a decision must be made about tools; should I buy off-the-shelf tools or should I develop my own. Either choice can involve significant cost and risk. Off-the-shelf tools may be readily available, but they can be expensive to purchase and to maintain licenses, and may not be flexible enough to satisfy all project requirements. On the other hand, developing new tools permits great flexibility, but it can be time- (and budget-) consuming, and the end product still may not work as intended. Open source software has the advantages of both approaches without many of the pitfalls. This paper examines the concept of open source software, including its history, unique culture, and informal yet closely followed conventions. These characteristics influence the quality and quantity of software available, and ultimately its suitability for serious ATR development work. We give an example where Python, an open source scripting language, and OpenEV, a viewing and analysis tool for geospatial data, have been incorporated into ATR performance evaluation projects. While this case highlights the successful use of open source tools, we also offer important insight into risks associated with this approach.

  13. [Progress and prospects on evaluation of ecological restoration: a review of the 5th World Conference on Ecological Restoration].

    Science.gov (United States)

    Ding, Jing-Yi; Zhao, Wen-Wu

    2014-09-01

    The 5th World Conference on Ecological Restoration was held in Madison, Wisconsin, USA on October 6-11, 2013. About 1200 delegates from more than 50 countries attended the conference, and discussed the latest developments in different thematic areas of ecological restoration. Discussions on evaluation of ecological restoration were mainly from three aspects: The construction for evaluation indicator system of ecological restoration; the evaluation methods of ecological restoration; monitoring and dynamic evaluation of ecological restoration. The meeting stressed the importance of evaluation in the process of ecological restoration and concerned the challenges in evaluation of ecological restoration. The conference had the following enlightenments for China' s research on evaluation of ecological restoration: 1) Strengthening the construction of comprehensive evaluation indicators system and focusing on the multi-participation in the evaluation process. 2) Paying more attentions on scale effect and scale transformation in the evaluation process of ecological restoration. 3) Expanding the application of 3S technology in assessing the success of ecological restoration and promoting the dynamic monitoring of ecological restoration. 4) Carrying out international exchanges and cooperation actively, and promoting China's international influence in ecological restoration research.

  14. Radioresistance of chordoma cells is associated with the ATM/ATR pathway, in which RAD51 serves as an important downstream effector.

    Science.gov (United States)

    Zhang, Chao; Wang, Bing; Li, Lei; Li, Yawei; Li, Pengzhi; Lv, Guohua

    2017-09-01

    Surgery followed by radiotherapy is the standard treatment for chordomas, which are a rare but low-grade type of bone cancer arising from remnants of the embryonic notochord. However, disease recurrence following radiotherapy is common, most likely due to endogenous DNA repair mechanisms that promote cell survival upon radiation strikes. The ataxia telangiectasia mutated/ataxia telangiectasia mutated and Rad3 related (ATM/ATR)-mediated pathway has a critical role in DNA repair mechanisms; however, it has rarely been investigated in chordomas. In the present study, the expression of signal molecules related to the ATM/ATR pathway in chordoma tissues and adjacent normal tissues were initially examined using immunohistochemistry and western blot analysis. Chordoma U-CH1 and U-CH2 cells were subsequently used to investigate cell responses to ionizing radiation and the potential protective actions mediated by the ATM/ATR pathway. Phosphorylated (p)-ATM, p-ATR, γ-H2A histone family, member X (H2AX) and RAD51 were significantly upregulated in chordoma tissues relative to adjacent normal tissues (PATM, γ-H2AX and RAD51 expression in U-CH1 cells (PATM, p-ATR and RAD51 levels in U-CH2 cells (PATM/ATR pathway, in which RAD51 serves as an important downstream effector. Thus, RAD51 presents a promising therapeutic target for improving the outcome of radiotherapy treatment in chordomas.

  15. Science journalists learn of scientific renaissance at Doha conference

    CERN Multimedia

    James Gillies

    2011-01-01

    Last week, over 700 science journalists from around the world made their way to Doha, Qatar, for the World Conference of Science Journalists. This meeting takes place every two years, and is the largest gathering of science writers in the world. Established in the early 1990s, this is the first time that a Middle Eastern country has hosted the conference, and it was quite an eye opener.   American-Egyptian Nobel Prize winner Ahmed Zewail delivers a keynote address at the World Conference of Science Journalists. Firstly, the large number of participants shows clearly that reports of the demise of science journalism seem to have been widely exaggerated. But it’s not only the number or participants that’s impressive: it’s also where they came from. Thanks in part to grants from the Qatar Foundation, 90 countries were represented with around 50% of participants coming from the developing world. One real eye-opener was the state of science in the Middle East. Originally s...

  16. News Event: UK to host Science on Stage Travel: Gaining a more global perspective on physics Event: LIYSF asks students to 'cross scientific boundaries' Competition: Young Physicists' tournament is international affair Conference: Learning in a changing world of new technologies Event: Nordic physical societies meet in Lund Conference: Tenth ESERA conference to publish ebook Meeting: Rugby meeting brings teachers together Note: Remembering John L Lewis OBE

    Science.gov (United States)

    2013-03-01

    Event: UK to host Science on Stage Travel: Gaining a more global perspective on physics Event: LIYSF asks students to 'cross scientific boundaries' Competition: Young Physicists' tournament is international affair Conference: Learning in a changing world of new technologies Event: Nordic physical societies meet in Lund Conference: Tenth ESERA conference to publish ebook Meeting: Rugby meeting brings teachers together Note: Remembering John L Lewis OBE

  17. 7. Eurasia Conference on Chemical Sciences (abstracts)

    International Nuclear Information System (INIS)

    Atta-ur-Rahman; Choudhary, M.I.

    2002-01-01

    The 7th Eurasia Conference on Chemical sciences (EuAs/sub 2/S-7) was held from 8-12 March, 2002 at Karachi, Pakistan. Scientists from thirty different countries had participated in this conference. Several topics from chemical world were highlighted in this conference including use of radioisotopes in different fields and specially environment which have been included here. (A.B)

  18. VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation

    International Nuclear Information System (INIS)

    Fujisawa, Hiroshi; Nakajima, Nakako Izumi; Sunada, Shigeaki; Lee, Younghyun; Hirakawa, Hirokazu; Yajima, Hirohiko; Fujimori, Akira; Uesaka, Mitsuru; Okayasu, Ryuichi

    2015-01-01

    High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than X-rays is still not completely understood. One factor would be the clustered or complex-type DNA damages. We previously reported that complex DNA double-strand breaks produced by high LET radiation enhanced DNA end resection, and this could lead to higher kinase activity of ATR protein recruited to RPA-coated single-stranded DNA. Although the effect of ATR inhibition on cells exposed to low LET gamma-rays has recently been reported, little is known regarding the effect of ATR inhibitor on cells treated with high LET radiation. The purpose of this study is to investigate the effects of the ATR inhibitor VE-821 in human tumor and normal cells irradiated with high LET carbon ions. HeLa, U2OS, and 1BR-hTERT (normal) cells were pre-treated with 1 μM VE-821 for 1 hour and irradiated with either high LET carbon ions or X-rays. Cell survival, cell cycle distribution, cell growth, and micronuclei formation were evaluated. VE-821 caused abrogation of G2/M checkpoint and forced irradiated cells to divide into daughter cells. We also found that carbon ions caused a higher number of multiple micronuclei than X-rays, leading to decreased cell survival in tumor cells when treated with VE-821, while the survival of irradiated normal cells were not significantly affected by this inhibitor. ATR inhibitor would be an effective tumor radiosensitizer with carbon ion irradiation. The online version of this article (doi:10.1186/s13014-015-0464-y) contains supplementary material, which is available to authorized users

  19. Inherited germline ATRX mutation in two brothers with ATR-X syndrome and osteosarcoma.

    Science.gov (United States)

    Ji, Jianling; Quindipan, Catherine; Parham, David; Shen, Lishuang; Ruble, David; Bootwalla, Moiz; Maglinte, Dennis T; Gai, Xiaowu; Saitta, Sulagna C; Biegel, Jaclyn A; Mascarenhas, Leo

    2017-05-01

    We report a family in which two brothers had an undiagnosed genetic disorder comprised of dysmorphic features, microcephaly, severe intellectual disability (non-verbal), mild anemia, and cryptorchidism. Both developed osteosarcoma. Trio exome sequencing (using blood samples from the younger brother and both parents) was performed and a nonsense NM_000489.4:c.7156C>T (p.Arg2386*) mutation in the ATRX gene was identified in the proband (hemizygous) and in the mother's peripheral blood DNA (heterozygous). The mother is healthy, does not exhibit any clinical manifestations of ATR-X syndrome and there was no family history of cancer. The same hemizygous pathogenic variant was confirmed in the affected older brother's skin tissue by subsequent Sanger sequencing. Chromosomal microarray studies of both brothers' osteosarcomas revealed complex copy number alterations consistent with the clinical diagnosis of osteosarcoma. Recently, somatic mutations in the ATRX gene have been observed as recurrent alterations in both osteosarcoma and brain tumors. However, it is unclear if there is any association between osteosarcoma and germline ATRX mutations, specifically in patients with constitutional ATR-X syndrome. This is the first report of osteosarcoma diagnosed in two males with ATR-X syndrome, suggesting a potential increased risk for cancer in patients with this disorder. © 2017 Wiley Periodicals, Inc.

  20. Considering the this-worldly religious focus of the African traditional worldview as found in South Africa

    Directory of Open Access Journals (Sweden)

    Desmond Henry

    2017-01-01

    Full Text Available Most articles evaluating the African traditional worldview focus an attack on the ancestor cult or highlight positive aspects of the worldview. In either case, mention of the this-worldly religious focus tends to be �in passing�. An evaluation of this aspect of the worldview is a gap in the research, which this article seeks to address. The findings should significantly affect evangelical ministry method to many people in the country. The this-worldly religious focus of the African traditional worldview as found in South Africa is considered. It is a focus which hardly, if ever, looks beyond this world and this age. The this-worldly focus is a significant feature of the African traditional worldview and related African Traditional Religion (ATR. The concern raised is that this feature of the worldview is prevalent in the country, is unbiblical and is a major problem affecting the church. The article first describes the this-worldly religious focus and how it is expressed in ATR and in those strongly influenced by ATR. It then discusses its prevalence in South Africa. A biblical evaluation is then done, considering what the Bible has to say on the matter and considering the views of some evangelicals. Finally, some proposals are made for responding to the challenge. There are significant steps that can be taken to counteract the problem and so design evangelism and discipleship that the African believers are moved to resist rather than follow the this-worldly religious focus and so more faithfully follow the way of our Lord.Intradisciplinary and/or interdisciplinary implications: Most articles evaluating the African traditional worldview focus an attack on the ancestor cult or highlight positive aspects of the worldview. In either case, mention of the this-worldly religious focus tend to be �in passing� across the research spectrum. An evaluation of this aspect of the worldview is a gap in the research across many disciplines, which this

  1. Energy and the public as viewed by the World Energy Conference. Energie und Oeffentlichkeit aus der Sicht der WEK

    Energy Technology Data Exchange (ETDEWEB)

    Wiedemann, P.M. (Kernforschungsanlage Juelich GmbH (Germany, F.R.). Programmgruppe Technik und Gesellschaft); Jungermann, H. (Technische Univ. Berlin (Germany, F.R.). Inst. fuer Psychologie)

    1989-09-01

    The committee 'Energy and the Public', set up by the World Energy Conference, at this year's meeting of the WEK presented a comparative international study on the attitude of the public towards systems of energy production, respectively energy supply. Attitudes towards a certain energy system depend on different aspects: With nuclear energy it is above all the safety aspect; for the rest, environmental-protection and economic aspects are important. But the conflict between materialistic and postmaterialistic values also influences people's energy-political convictions. What this study documents is the origin of a world-wide problem-consciousness that energy policy has to contend with if it wants to be economically, environmentally, and socially compatible. (orig./UA).

  2. CERN automatic audio-conference service

    CERN Multimedia

    Sierra Moral, R

    2009-01-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first Euro...

  3. CERN automatic audio-conference service

    CERN Document Server

    Sierra Moral, R

    2010-01-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first Euro...

  4. Introduction: film-philosophy and a world of cinemas

    OpenAIRE

    Martin-Jones, David

    2016-01-01

    This Special Section arose out of the 2014 Film-Philosophy conference,\\ud held at the University of Glasgow, which took as its theme: A World of\\ud Cinemas. The aim of both the conference theme and this resulting Special\\ud Section is to broaden the debate in film-philosophy, both in terms of a\\ud world of cinemas and a world of philosophies. This introduction considers\\ud the reasons why such an intervention is worthwhile.

  5. Measured thermal and fast neutron fluence rates ATR Cycle 101-B, October 11, 1993--November 27, 1993

    International Nuclear Information System (INIS)

    Murray, R.K.; Rogers, J.W.

    1994-01-01

    This report contains the thermal (2200 m/s) and fast (E>lMeV) neutron fluence rate data for ATR Cycle 101-B which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains fluence rate values corresponding to the particular elevations (relative to the 80 ft. core elevation) where the measurements were taken. The data in this report consists of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, (3) plots of both the thermal and fast neutron fluence rates, and (4) a magnetic record (3.5 inch diskette) containing a listing of only the fast neutron fluence rates, their assigned elevations proper header identification of all monitor positions contained herein

  6. ON-LINE MONITORING OF I&C TRANSMITTERS AND SENSORS FOR CALIBRATION VERIFICATION AND RESPONSE TIME TESTING WAS SUCCESSFULLY IMPLEMENTED AT ATR

    Energy Technology Data Exchange (ETDEWEB)

    Erickson, Phillip A.; O' Hagan, Ryan; Shumaker, Brent; Hashemian, H. M.

    2017-03-01

    The Advanced Test Reactor (ATR) has always had a comprehensive procedure to verify the performance of its critical transmitters and sensors, including RTDs, and pressure, level, and flow transmitters. These transmitters and sensors have been periodically tested for response time and calibration verification to ensure accuracy. With implementation of online monitoring techniques at ATR, the calibration verification and response time testing of these transmitters and sensors are verified remotely, automatically, hands off, include more portions of the system, and can be performed at almost any time during process operations. The work was done under a DOE funded SBIR project carried out by AMS. As a result, ATR is now able to save the manpower that has been spent over the years on manual calibration verification and response time testing of its temperature and pressure sensors and refocus those resources towards more equipment reliability needs. More importantly, implementation of OLM will help enhance the overall availability, safety, and efficiency. Together with equipment reliability programs of ATR, the integration of OLM will also help with I&C aging management goals of the Department of Energy and long-time operation of ATR.

  7. 1995 World Conference on Women. African Regional Preparatory Conference, November 94, Dakar.

    Science.gov (United States)

    1995-04-01

    During the African Regional Preparatory Conference, held in Dakar in November 1994, the Inter-African Committee on Traditional Practices Affecting the Health of Women and Children (IAC) organized a workshop on "Traditional Practices and Beliefs as a Violation of the Human Rights of the Woman and the Girl Child" in collaboration with the Organisation of African Unity (OAU) and the UN Economic Commission for Africa (ECA). Eight panelists shared their country experiences and made proposals for eradicating harmful traditional practices. A film was shown, and Mrs. Marianne Sidibe, president of the Senegalese IAC National Committee, gave a vivid description of female genital mutilation (FGM). Proposals made during the workshop include 1) a follow-up workshop in Beijing; 2) inclusion of IAC concerns in the Platform of Action; 3) integration of IAC concerns into the national health programs of African nations with allocated budgets for implementation; 4) strengthening of interagency collaboration with governments; 5) adoption of legislation prohibiting harmful traditional practices such as FGM; 6) a minimum legal age for marriage of 18 years; 7) inclusion of information on traditional practices and gender sensitivity in primary and high school curricula; 8) involvement of youth in the campaign against harmful traditional practices; 9) regular evaluation of IAC activities; and 10) education of parents concerning gender equality. The African Platform for Action adopted by the conference considers FGM a form of violence against women.

  8. International conference centre, Geneva, Switzerland

    CERN Multimedia

    PH Department

    2009-01-01

    On 16-17 March 2009 the Energy Pact Foundation will be holding the Energy Pact Conference in Geneva. The Conference is organised with the support of the Republic and Canton of Geneva and has the Financial Times as its media partner. It will address for the first time in a comprehensive and integrated manner the key issues of energy needs and environmental and developmental challenges. Some 800 stakeholders and experts on these issues are expected. These will include high-level government officials, opinion leaders and representatives from the United Nations, NGOs, industry, civil society and the academic world. Gerhard Schröder, former Chancellor of Germany, will chair the Conference. Speakers with different backgrounds and expertise will include Dr. Carlo Rubia, Nobel Prize Winner, Ali Al-Naimi, Minister of Petroleum and Mineral Resources of Saudi Arabia, Gholam Hossein Nozari, Oil Minister of Iran, Gary Ross, CEO of PIRA Energy, a world-renowned energy market specialist, Ashok Khosla, President of the In...

  9. Solid Acid-Catalyzed Cellulose Hydrolysis Monitored by In Situ ATR-IR Spectroscopy

    NARCIS (Netherlands)

    Zakzeski, J.; Grisel, R.J.H.; Smit, A.T.; Weckhuysen, B.M.

    2012-01-01

    The solid acid-catalyzed hydrolysis of cellulose was studied under elevated temperatures and autogenous pressures using in situ ATR-IR spectroscopy. Standards of cellulose and pure reaction products, which include glucose, fructose, hydroxymethylfurfural (HMF), levulinic acid (LA), formic acid, and

  10. Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report October 2014

    Energy Technology Data Exchange (ETDEWEB)

    Ogden, Dan [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-10-01

    Advanced Test Reactor National Scientific User Facility (ATR NSUF) Monthly Report October 2014 Highlights • Rory Kennedy, Dan Ogden and Brenden Heidrich traveled to Germantown October 6-7, for a review of the Infrastructure Management mission with Shane Johnson, Mike Worley, Bradley Williams and Alison Hahn from NE-4 and Mary McCune from NE-3. Heidrich briefed the group on the project progress from July to October 2014 as well as the planned path forward for FY15. • Jim Cole gave two invited university seminars at Ohio State University and University of Florida, providing an overview of NSUF including available capabilities and the process for accessing facilities through the peer reviewed proposal process. • Jim Cole and Rory Kennedy co-chaired the NuMat meeting with Todd Allen. The meeting, sponsored by Elsevier publishing, was held in Clearwater, Florida, and is considered one of the premier nuclear fuels and materials conferences. Over 340 delegates attended with 160 oral and over 200 posters presented over 4 days. • Thirty-one pre-applications were submitted for NSUF access through the NE-4 Combined Innovative Nuclear Research Funding Opportunity Announcement. • Fourteen proposals were received for the NSUF Rapid Turnaround Experiment Summer 2014 call. Proposal evaluations are underway. • John Jackson and Rory Kennedy attended the Nuclear Fuels Industry Research meeting. Jackson presented an overview of ongoing NSUF industry research.

  11. Learning in a technology enhanced world

    OpenAIRE

    Specht, Marcus

    2010-01-01

    Specht, M. (2009). Learning in a technology enhanced world. Invited talk given at the World Conference on E-learning in Corporate, Government, Healthcare & Higher Education. October, 27, 2009, Vancouver, Canada.

  12. World Gas Conference 1997. Working committee H. Liquefied gases

    International Nuclear Information System (INIS)

    1997-01-01

    This volume of the proceedings contains the report of the International Gas Union's Working Committee H, Liquefied gases, and oral and poster papers presented at the conference. The committee report and each paper have been abstracted separately. (LN)

  13. Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) in the discrimination of normal and oral cancer blood plasma

    Science.gov (United States)

    Pachaiappan, Rekha; Prakasarao, Aruna; Singaravelu, Ganesan

    2017-02-01

    Oral cancer is the most frequent type of cancer that occurs with 75000 to 80000 new cases reported every year in India. The carcinogens from tobacco and related products are the main cause for the oral cancer. ATR-FTIR method is label free, fast and cost-effective diagnostic method would allow for rapid diagnostic results in earlier stages by the minimal chemical changes occur in the biological metabolites available in the blood plasma. The present study reports the use of ATR-FTIR data with advanced statistical model (LDA-ANN) in the diagnosis of oral cancer from normal with better accuracy. The infrared spectra were acquired on ATR-FTIR Jasco spectrophotometer at 4 cm-1 resolution, 30 scans, in the 1800-900 cm-1 spectral range. Each sample had 5 spectra recorded from each blood plasma sample. The spectral data were routed through the multilayer perception of artificial neural network to evaluate for the statistical efficacy. Among the spectral data it was found that amide II (1486 cm-1) and lipid (1526 cm-1) affords about 90 % in the discrimination between groups using LDA. These preliminary results indicate that ATR-FTIR is useful to differentiate normal subject from oral cancer patients using blood plasma.

  14. Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair.

    Science.gov (United States)

    Lima, Michelle; Bouzid, Hana; Soares, Daniele G; Selle, Frédéric; Morel, Claire; Galmarini, Carlos M; Henriques, João A P; Larsen, Annette K; Escargueil, Alexandre E

    2016-05-03

    Trabectedin (Yondelis®, ecteinascidin-743, ET-743) is a marine-derived natural product approved for treatment of advanced soft tissue sarcoma and relapsed platinum-sensitive ovarian cancer. Lurbinectedin is a novel anticancer agent structurally related to trabectedin. Both ecteinascidins generate DNA double-strand breaks that are processed through homologous recombination repair (HRR), thereby rendering HRR-deficient cells particularly sensitive. We here characterize the DNA damage response (DDR) to trabectedin and lurbinectedin in HeLa cells. Our results show that both compounds activate the ATM/Chk2 (ataxia-telangiectasia mutated/checkpoint kinase 2) and ATR/Chk1 (ATM and RAD3-related/checkpoint kinase 1) pathways. Interestingly, pharmacological inhibition of Chk1/2, ATR or ATM is not accompanied by any significant improvement of the cytotoxic activity of the ecteinascidins while dual inhibition of ATM and ATR strongly potentiates it. Accordingly, concomitant inhibition of both ATR and ATM is an absolute requirement to efficiently block the formation of γ-H2AX, MDC1, BRCA1 and Rad51 foci following exposure to the ecteinascidins. These results are not restricted to HeLa cells, but are shared by cisplatin-sensitive and -resistant ovarian carcinoma cells. Together, our data identify ATR and ATM as central coordinators of the DDR to ecteinascidins and provide a mechanistic rationale for combining these compounds with ATR and ATM inhibitors.

  15. 3. world TRIGA users conference. Papers and abstracts

    International Nuclear Information System (INIS)

    2006-01-01

    The Conference is focused on TRIGA reactors operation and applications. The main topics are: use of the reactor as a research tool; inspection of spent fuel elements; integrity of fuel rods cladding checks; evaluation of corrosion of aluminum-base fuel cladding materials; Pitting behavior of Aluminum alloys; Monte Carlo simulation of TRIGA: reactivity worth, burnup, flux and power; irradiation facilities; thermal hydraulics analyses etc

  16. Conference Proceedings: Meeting the challenge

    International Nuclear Information System (INIS)

    1998-01-01

    New developments in the international energy sector were the central theme of this conference, with more than 20 speakers from around the world addressing issues regarding the integration and expansion of world oil and gas markets. The issue of mergers and acquisitions, especially in the U.S. downstream, also received considerable attention. The conference was organized into seven sessions. Session titles, denoting the topic of major interest in each case, were as follows: (1) the concept of a 'core' business in the petroleum and natural gas industry, (2) strategies to capture the upstream petroleum industry, (3) upstream technology for offshore applications, (4) upstream technology for onshore applications, (5) making business less risky, (6) natural gas as the key ingredient to future growth by the world's major oil and gas companies, and (7) the issue of geopolitics and how it continues to play a major role in the global energy markets. refs., tabs., figs

  17. Rabi like angular splitting in Surface Plasmon Polariton - Exciton interaction in ATR configuration

    Science.gov (United States)

    Hassan, Heba; Abdallah, T.; Negm, S.; Talaat, H.

    2018-05-01

    We have studied the coupling of propagating Surface Plasmon Polaritons (SPP) on silver films and excitons in CdS quantum dots (QDs). We employed the Kretschmann-Raether configuration of the attenuated total reflection (ATR) to propagate the SPP on silver film of thickness 47.5 nm at three different wavelengths. The CdS QD have been chemically synthesized with particular size such that its exciton of energy would resonate with SPP. High resolution transmission electron microscopy (HRTEM) and scan tunneling microscopy (STM) were used to measure the corresponding QDs size and confirm its shape. Further confirmation of the size has been performed by the effective mass approximation (EMA) model utilizing the band gap of the prepared QDs. The band gaps have been measured through UV-vis absorption spectra as well as scan tunneling spectroscopy (STS). The coupling has been observed as two branching dips in the ATR spectra indicating Rabi like splitting. To the best of our knowledge, this is the first time that Rabi interaction is directly observed in an ATR angular spectra. This observation is attributed to the use a high resolution angular scan (±0.005°), in addition to the Doppler width of the laser line as well as the energy distribution of the excitons. The effect of three different linker molecules (TOPO, HDA), (Pyridine) and (Tri-butylamine) as surface ligands, on SPP-Exciton interaction has been examined.

  18. CERN automatic audio-conference service

    International Nuclear Information System (INIS)

    Sierra Moral, Rodrigo

    2010-01-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first European pilot and several improvements (such as billing, security, redundancy...) were implemented based on CERN's recommendations. The new automatic conference system has been operational since the second half of 2006. It is very popular for the users and has doubled the number of conferences in the past two years.

  19. CERN automatic audio-conference service

    Energy Technology Data Exchange (ETDEWEB)

    Sierra Moral, Rodrigo, E-mail: Rodrigo.Sierra@cern.c [CERN, IT Department 1211 Geneva-23 (Switzerland)

    2010-04-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first European pilot and several improvements (such as billing, security, redundancy...) were implemented based on CERN's recommendations. The new automatic conference system has been operational since the second half of 2006. It is very popular for the users and has doubled the number of conferences in the past two years.

  20. CERN automatic audio-conference service

    Science.gov (United States)

    Sierra Moral, Rodrigo

    2010-04-01

    Scientists from all over the world need to collaborate with CERN on a daily basis. They must be able to communicate effectively on their joint projects at any time; as a result telephone conferences have become indispensable and widely used. Managed by 6 operators, CERN already has more than 20000 hours and 5700 audio-conferences per year. However, the traditional telephone based audio-conference system needed to be modernized in three ways. Firstly, to provide the participants with more autonomy in the organization of their conferences; secondly, to eliminate the constraints of manual intervention by operators; and thirdly, to integrate the audio-conferences into a collaborative working framework. The large number, and hence cost, of the conferences prohibited externalization and so the CERN telecommunications team drew up a specification to implement a new system. It was decided to use a new commercial collaborative audio-conference solution based on the SIP protocol. The system was tested as the first European pilot and several improvements (such as billing, security, redundancy...) were implemented based on CERN's recommendations. The new automatic conference system has been operational since the second half of 2006. It is very popular for the users and has doubled the number of conferences in the past two years.

  1. [World plan for reproductive autonomy and health].

    Science.gov (United States)

    Ospina, P

    1994-06-01

    The principal objective of the Third International Conference on Population and Development to be held in Cairo in 1994 is to achieve consensus on a Plan of Action to reinforce reproductive rights of individuals, who bear ultimate responsibility for slowing population growth. The Plan of Action should be adopted by all the peoples of the world in order to stabilize population growth during the next twenty years by means of programs to provide family planning and reproductive health services. The preliminary conference document incorporated recommendations and proposals of two preparatory committees, five regional conferences, six expert meetings, 109 countries, and over 400 nongovernmental organizations from around the world. At current rates of growth, the world's 5.7 billion inhabitants will increase to 9.1 billion by the year 2025, vastly increasing pressure on already limited resources and ecosystems. The central theme of the first World Population Conference in Bucharest in 1974 was the close relationship between population growth and socioeconomic development. The 1974 World Population Plan of Action stressed development of strategies to achieve a better quality of life and rapid socioeconomic development. Recommendations of the 1984 World Population Conference in Mexico remained centered on implementation of the Bucharest Plan of Action with a few additions. Although progress has been achieved in meeting the goals of the Bucharest Plan of Action, growth rates of some developing countries have actually increased. Poverty, unemployment, illiteracy, and discrimination against women are still obstacles to socioeconomic development, and contraceptive usage has not reached optimal levels. Urban migration remains excessive. Progress for many countries over the past decade has been directly related to increasing the access of women to health care and family planning. Themes related to women's status and rights will be incorporated in the 1994 Cairo Conference. The

  2. Investigation on the adsorption characteristics of sodium benzoate and taurine on gold nanoparticle film by ATR-FTIR spectroscopy

    Science.gov (United States)

    Kumar, Naveen; Thomas, S.; Tokas, R. B.; Kshirsagar, R. J.

    2014-01-01

    Fourier transform infrared (FTIR) spectroscopic studies of sodium benzoate and taurine adsorbed on gold nanoparticle (AuNp) film on silanised glass slides have been studied by attenuated total reflection technique (ATR). The surface morphology of the AuNp films has been measured by Atomic Force Microscopy. The ATR spectra of sodium benzoate and taurine deposited on AuNp film are compared with ATR spectra of their powdered bulk samples. A new red-shifted band appeared along with the symmetric and asymmetric stretches of carboxylate group of sodium benzoate leading to a broadening of the above peaks. Similar behavior is also seen in the case of symmetric and asymmetric stretches of sulphonate group of taurine. The results indicate presence of both chemisorbed and physisorbed layers of both sodium benzoate and taurine on the AuNp film with bottom layer chemically bound to AuNp through carboxylate and sulphonate groups respectively.

  3. Conference on High Energy Physics

    CERN Document Server

    2016-01-01

    Conference on High Energy Physics (HEP 2016) will be held from August 24 to 26, 2016 in Xi'an, China. This Conference will cover issues on High Energy Physics. It dedicates to creating a stage for exchanging the latest research results and sharing the advanced research methods. HEP 2016 will be an important platform for inspiring international and interdisciplinary exchange at the forefront of High Energy Physics. The Conference will bring together researchers, engineers, technicians and academicians from all over the world, and we cordially invite you to take this opportunity to join us for academic exchange and visit the ancient city of Xi’an.

  4. The 9. European nuclear conference

    International Nuclear Information System (INIS)

    Maurel, V.; Lewis, D.; Smirnov, V.P.; Gutierrez, J.E.; Paulin, Ph.; Markov, D.V.; Smirnov, A.V.; Polenok, V.S.; Horhoianu, G.; Olteanu, G.; Van der Schaaf, B.; Gavillet, D.; Lapena, J.; Ohms, C.; Roth, A.; Van Dyck, St.; Mardon, J.P.; Thomas, A.; Cipiere, M.F.; Faidy, C.; Hedin, F.; Delnondedieu, M.; Chassignole, B.; Doudet, L.; Dupond, O.; Kang, K.; Park, K.; Kim, K.; Ha, J.; Hoon-Seok, Jung; Yong-koo, Lee; Kwang-Ho, Kim; Seungwoo, Paek; Heui-Joo, Choi; Do-Hee, Ahn; Kwang-Rag, Kim; Minsoo, Lee; Sung-Paal, Yim; Hongsuk, Chung; Detroux, P.; Meessen, O.; Defloor, J.; Lars-Erik, Holm; Barescut, J.C.; Vacquier, B.; Laurier, D.; Caer, S.; Quesne, B.; Oudalova, A.; Geras'kin, St.; Dikarev, V.; Dikareva, N.; Chernonog, E.; Yang-Geun, Chung; Gab-Bock, Lee; Sun-Young, Bang; Yong-Sun, Lee; Bolognese-Milsztajn, T.; Frank, D.; Lacoste, V.; Pihet, P.; Lacronique, J.F.; Chauliac, C.; Verwaerde, D.; Pavageau, O.; Zaetta, A.; Varaine, F.; Warin, D.; Hudelot, J.P.; Bioux, Ph.; Klann, R.; Petruzzi, A.; D'auria, F.; Yung Kwon, Jin; Chul Jin, Chol; Mihalache, M.; Radu, V.; Pavelescu, M.; Schneidesch, Ch.R.; Jinzhao, Zhang; Dalleur, J.P.; Nuttin, A.; Meplan, O.; Wilson, J.; Perdu, F.; Campioni, G.; Mounier, C.; Sigrist, J.F.; Laine, Ch.; Broc, D.; Robbe, M.F.; Cariou, Y.; Seok-Kyun, Yoon; Win, Naing; Myung-Hyun, Kim; Kyung, Hee; Fridman, E.; Shwageraus, E.; Galperin, A.; Meplan, O.; Laulan, O.; Mechel-Sendis, F.; Belgaid, M.; Kadem, F.; Amokrane, A.; Hamidouche, T.; El-Khider, Si-Ahmed

    2005-01-01

    This issue gathers the abstracts of the papers presented at the ninth European nuclear conference (ENC-2005). The main part of the conference is split into 20 sessions. These sessions cover all technical aspects of nuclear power, from reactor design to waste management, without forgetting experimental and research reactors, reactor dismantling, economy, resources, safety, radioprotection and education issues. Perspectives of a nuclear renaissance are clearly visible in the world. This renaissance, mainly due to political, economical, societal and ecological factors, is fuelled by scientific and technical progress. This conference was the opportunity to present together these aspects of nuclear power and to analyze their mutual interactions

  5. Neutronics analysis of the DHCE experiment in ATR-ITV

    Energy Technology Data Exchange (ETDEWEB)

    Gomes, I.C.; Smith, D.L.; Tsai, H. [Argonne National Lab., IL (United States)

    1997-08-01

    The preliminary analysis of the DHCE experiments in the ITV and ATR was performed and its was concluded that such a vehicle is suitable for this kind of experiment. It is recommended to place an extra filter material in the thermocouple sleeve (such as B-10), to improve the helium to dpa ratio profile during irradiation. Also, it was concluded that a preliminary estimation of period of time for replacement of the external filter would be around 5 dps`s.

  6. Twenty-fifth Semiannual Report of the Commission to the Congress, January 1959. Atomic Industrial Process and Second World Conference, July - December 1958

    Energy Technology Data Exchange (ETDEWEB)

    McCone, John A.

    1959-01-31

    The document represents the twenty-fifth semiannual Atomic Energy Commission (AEC) report to Congress. The report sums up the major activities and developments in the national atomic energy program in Part Three, covering the period July - December 1958. A special Part One of this semiannual report is titled ''Industrial Atomic Progress During 1958", and a Part Two entitled "Second World Conference on Peaceful Uses of Atomic Energy".

  7. China's Soft Diplomacy in an Emerging Multi-polar World

    DEFF Research Database (Denmark)

    Schmidt, Johannes Dragsbæk

    Keynote presentation for the conference"The Growing Prominence of China on the World Stage: Exploring the Political, Economic, and Cultural Relations of China and Global Stakeholders" International Conference, Berlin, September 15th - 18th, 2011 - Held Parallel to the "Berlin - Asia Pacific Weeks...... Conference 2011...

  8. Context and Quasi-Invariants in Automatic Target Recognition (ATR) with Synthetic Aperture Radar (SAR) Imagery

    National Research Council Canada - National Science Library

    Binford, Thomas

    2000-01-01

    .... Experiments based on conventional recognition techniques were conducted for comparisons. Study of persistent scattering confirms the feasibility of implementing a SAR ATR system using physical image features...

  9. “Il Dolore, il Lutto, la Gloria. Rappresentazioni Fotografiche della Grande Guerra fra Pubblico e Privato, 1914-1940” a Conference on the First World War and its Representations

    OpenAIRE

    Gianluigi Di Giangirolamo

    2016-01-01

    On the occasion of the First World War Centenary, the Department for Cultural Heritage of the University of Bologna in Ravenna together with the SISF Italian Society for the Study on photography, promoted the conference Il dolore, il lutto, la gloria. Rappresentazioni fotografiche della grande guerra fra pubblico e privato, 1914-1940 between 26-28 May, 2016. The conference was organised in collaboration with the University of Padova, the Fundation of Historical Studies Filippo Turati of Flore...

  10. 28th Linear Accelerator Conference

    CERN Document Server

    Facco, Alberto; McCausey, Amy; Schaa, Volker R W

    2017-01-01

    The 28th Linear Accelerator Conference, LINAC 16, to take place at the Kellogg Hotel and Conference Center in East Lansing, Michigan, on 25-30 September 2016. This conference is the main bi-yearly gathering for the world-wide community of linac specialists. It provides a unique opportunity to hear about the latest advances of projects and developments concerning hadron and lepton linacs, and their applications. In the tradition of previous LINAC conferences, plenary sessions including invited speakers are scheduled every day. Poster sessions will be held on Monday, Tuesday and Thursday afternoons. There will also be two special events on Sunday, 25 September 2016, namely a student poster session and an evening reception for registrants and their companions at the Kellogg Hotel and Conference Center. Participants are also warmly invited to join an outing to Lake Michigan and the beautiful surroundings on Wednesday afternoon, and to visit the Facility for Rare Isotope Beams on Friday afternoon, after the formal...

  11. Raman and IR-ATR spectroscopy studies of heteroepitaxial structures with a GaN:C top layer

    Science.gov (United States)

    Cerqueira, M. F.; Vieira, L. G.; Alves, A.; Correia, R.; Huber, M.; Andreev, A.; Bonanni, A.; Vasilevskiy, M. I.

    2017-09-01

    This work, motivated by the technologically important task of determination of carbon dopant location in the GaN crystal lattice, employed Raman spectroscopy, with both resonant and non-resonant excitation, and infrared (IR) spectroscopy, in the attenuated total reflection (ATR) configuration, to study lattice vibration modes in a set of carbon-doped GaN (GaN:C) epilayers grown by metalorganic vapour phase epitaxy. We analyse Raman and IR-ATR spectra from the point of view of possible effects of the carbon doping, namely: (i) local vibration mode of C atoms in the nitrogen sublattice (whose frequency we theoretically estimate as 768 cm-1 using an isotope defect model), and (ii) shift in the positions of longitudinal modes owing to the phonon-plasmon coupling. We find only indirect hints of the doping effect on the resonant Raman spectra. However, we show theoretically and confirm experimentally that the IR-ATR spectroscopy can be a much more sensitive tool for this purpose, at least for the considered structures. A weak perturbation of the dielectric function of GaN:C, caused by the substitutional carbon impurity, is shown to produce a measurable dip in the ATR reflectivity spectra at  ≈770 cm-1 for both p- and s-polarizations. Moreover, it influences a specific (guided-wave type) mode observed at  ≈737 cm-1, originating from the GaN layer, which appears in the narrow frequency window where the real parts of the two components of the dielectric tensor of the hexagonal crystal have opposite signs. This interpretation is supported by our modelling of the whole multilayer structure, using a transfer matrix formalism.

  12. ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

    Czech Academy of Sciences Publication Activity Database

    Kumar, A.; Mazzanti, M.; Mistrik, M.; Košař, Martin; Beznoussenko, G.V.; Mironov, A. A.; Garrè, M.; Parazolli, D.; Shivashankar, G. V.; Scita, G.; Bartek, Jiří; Foiani, M.

    2014-01-01

    Roč. 158, č. 3 (2014), s. 633-646 ISSN 0092-8674 Grant - others:Marie Curie Intra-European(IT) 274093 Institutional support: RVO:68378050 Keywords : ATR * Mechanical Stress * cell cycle Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 32.242, year: 2014

  13. Improving precursor adsorption characteristics in ATR-FTIR spectroscopy with a ZrO{sub 2} nanoparticle coating

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jaeseo [Korea Research Institute of Standards and Science, Center for Vacuum Technology (Korea, Republic of); Mun, Jihun [University of Science and Technology, Department of Advanced Device Technology (Korea, Republic of); Shin, Jae-Soo; Kim, Jongho; Park, Hee Jung [Daejeon University, Department of Advanced Materials Engineering (Korea, Republic of); Kang, Sang-Woo, E-mail: swkang@kriss.re.kr [Korea Research Institute of Standards and Science, Center for Vacuum Technology (Korea, Republic of)

    2017-02-15

    Nanoparticles were applied to a crystal surface to increase its precursor adsorption efficiency in an attenuated total reflection Fourier transform infrared (ATR-FTIR) spectrometer. Nanoparticles with varying dispersion stabilities were employed and the resulting precursor adsorption characteristics were assessed. The size of the nanoparticles was <100 nm (TEM). In order to vary the dispersion stability, ZrO{sub 2} nanoparticles were dispersed in aqueous solutions of different pH. The ZrO{sub 2} dispersion solutions were analyzed using scanning electron microscopy (SEM) while particle distribution measurements were analyzed using electrophoretic light scattering (ELS) and dynamic light scattering (DLS) techniques. ZrO{sub 2} nanoparticles dispersed in solutions of pH 3 and 11 exhibited the most stable zeta potentials (≥+30 or ≤−30 mV); these observations were confirmed by SEM analysis and particle distribution measurements. Hexamethyldisilazane (HMDS) was used as a precursor for ATR-FTIR spectroscopy. Consequently, when ZrO{sub 2} nanoparticle solutions with the best dispersion stabilities (pH 3 and 11) were applied to the adsorption crystal surface, the measurement efficiency of ATR-FTIR spectroscopy improved by ∼200 and 300%, respectively.

  14. The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.

    Science.gov (United States)

    Vendetti, Frank P; Lau, Alan; Schamus, Sandra; Conrads, Thomas P; O'Connor, Mark J; Bakkenist, Christopher J

    2015-12-29

    ATR and ATM are DNA damage signaling kinases that phosphorylate several thousand substrates. ATR kinase activity is increased at damaged replication forks and resected DNA double-strand breaks (DSBs). ATM kinase activity is increased at DSBs. ATM has been widely studied since ataxia telangiectasia individuals who express no ATM protein are the most radiosensitive patients identified. Since ATM is not an essential protein, it is widely believed that ATM kinase inhibitors will be well-tolerated in the clinic. ATR has been widely studied, but advances have been complicated by the finding that ATR is an essential protein and it is widely believed that ATR kinase inhibitors will be toxic in the clinic. We describe AZD6738, an orally active and bioavailable ATR kinase inhibitor. AZD6738 induces cell death and senescence in non-small cell lung cancer (NSCLC) cell lines. AZD6738 potentiates the cytotoxicity of cisplatin and gemcitabine in NSCLC cell lines with intact ATM kinase signaling, and potently synergizes with cisplatin in ATM-deficient NSCLC cells. In contrast to expectations, daily administration of AZD6738 and ATR kinase inhibition for 14 consecutive days is tolerated in mice and enhances the therapeutic efficacy of cisplatin in xenograft models. Remarkably, the combination of cisplatin and AZD6738 resolves ATM-deficient lung cancer xenografts.

  15. DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair.

    Science.gov (United States)

    Serrano, M A; Li, Z; Dangeti, M; Musich, P R; Patrick, S; Roginskaya, M; Cartwright, B; Zou, Y

    2013-05-09

    Homologous recombination (HR) and nonhomologous end joining (NHEJ) are two distinct DNA double-stranded break (DSB) repair pathways. Here, we report that DNA-dependent protein kinase (DNA-PK), the core component of NHEJ, partnering with DNA-damage checkpoint kinases ataxia telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR), regulates HR repair of DSBs. The regulation was accomplished through modulation of the p53 and replication protein A (RPA) interaction. We show that upon DNA damage, p53 and RPA were freed from a p53-RPA complex by simultaneous phosphorylations of RPA at the N-terminus of RPA32 subunit by DNA-PK and of p53 at Ser37 and Ser46 in a Chk1/Chk2-independent manner by ATR and ATM, respectively. Neither the phosphorylation of RPA nor of p53 alone could dissociate p53 and RPA. Furthermore, disruption of the release significantly compromised HR repair of DSBs. Our results reveal a mechanism for the crosstalk between HR repair and NHEJ through the co-regulation of p53-RPA interaction by DNA-PK, ATM and ATR.

  16. ATR-FTIR for rapid detection and quantification of counterfeit medicines

    OpenAIRE

    Ogwu, John; Lawson, Graham; Tanna, Sangeeta

    2015-01-01

    From therapeutic to lifestyle medicines, the counterfeiting of medicines has been on the rise in recent times [1]. Estimates indicate that about 10% of medicines worldwide are counterfeits with much higher figures in developing countries [2]. Currently, the rapid screening of medicines is a challenge leaving many patients at risk [1]. This study considered the potential use of Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR) for rapid quantitative analysis of ta...

  17. Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage*

    Science.gov (United States)

    Acevedo, Julyana; Yan, Shan; Michael, W. Matthew

    2016-01-01

    A critical event for the ability of cells to tolerate DNA damage and replication stress is activation of the ATR kinase. ATR activation is dependent on the BRCT (BRCA1 C terminus) repeat-containing protein TopBP1. Previous work has shown that recruitment of TopBP1 to sites of DNA damage and stalled replication forks is necessary for downstream events in ATR activation; however, the mechanism for this recruitment was not known. Here, we use protein binding assays and functional studies in Xenopus egg extracts to show that TopBP1 makes a direct interaction, via its BRCT2 domain, with RPA-coated single-stranded DNA. We identify a point mutant that abrogates this interaction and show that this mutant fails to accumulate at sites of DNA damage and that the mutant cannot activate ATR. These data thus supply a mechanism for how the critical ATR activator, TopBP1, senses DNA damage and stalled replication forks to initiate assembly of checkpoint signaling complexes. PMID:27129245

  18. AGR-2 Final Data Qualification Report for U.S. Capsules - ATR Cycles 147A Through 154B

    Energy Technology Data Exchange (ETDEWEB)

    Pham, Binh T. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Very High-Temperature Reactor Technology Development Office; Einerson, Jeffrey J. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Very High-Temperature Reactor Technology Development Office

    2014-07-01

    This report provides the data qualification status of AGR-2 fuel irradiation experimental data in four U.S. capsules from all 15 Advanced Test Reactor (ATR) Cycles 147A, 148A, 148B, 149A, 149B, 150A, 150B, 151A, 151B, 152A, 152B, 153A, 153B, 154A, and 154B, as recorded in the Nuclear Data Management and Analysis System (NDMAS). Thus, this report covers data qualification status for the entire AGR-2 irradiation and will replace four previously issued AGR-2 data qualification reports (e.g., INL/EXT-11-22798, INL/EXT-12-26184, INL/EXT-13-29701, and INL/EXT-13-30750). During AGR-2 irradiation, two cycles, 152A and 153A, occurred when the ATR core was briefly at low power, so AGR-2 irradiation data are not used for physics and thermal calculations. Also, two cycles, 150A and 153B, are Power Axial Locator Mechanism (PALM) cycles when the ATR power is higher than during normal cycles. During the first PALM cycle, 150A, the experiment was temporarily moved from the B-12 location to the ATR water canal and during the second PALM cycle, 153B, the experiment was temporarily moved from the B-12 location to the I-24 location to avoid being overheated. During the “Outage” cycle, 153A, seven flow meters were installed downstream from seven Fission Product Monitoring System (FPMS) monitors to measure flows from the monitors and these data are included in the NDMAS database.

  19. Worldwide natural gas vehicles become reality. World conference for natural gas vehicles HGV`98 in Cologne; Erdgasfahrzeuge werden weltweit Realitaet. Weltkonferenz fuer Erdgasfahrzeuge NGV`98 in Koeln

    Energy Technology Data Exchange (ETDEWEB)

    Ganser, B. [Rhenag Rheinische Energie AG, Koeln (Germany)

    1998-07-01

    The 6th World Conference for natural gas vehicles (NGV `98) which was held from May 26th-28th, 1998 in Cologne under the patronage of the Federal Environment Minister Dr. Angela Merkel, lead more than 1000 participants from all over the world to the Cathedral City. The conference, accompanied by an exhibition at which 65 exhibitors showed the newest trends in the vehicle- and filling station technology, was made use of by more than 2000 visitors to inform themselves about the latest technical developments. With this extremely positive resonance of visitors for the conference and trade exhibition, the NGV `98 so far is worldwide the largest event on alternative vehicle drivers. (orig.) [Deutsch] Die 6. Weltkonferenz fuer Erdgasfahrzeuge (NGV `98), die vom 26. bis 28. Maerz 1998 in Koeln unter der Schirmherrschaft von Bundesumweltministerin Dr. Angela Merkel stattfand, fuehrte mehr als 1000 Teilnehmer aus aller Welt in die Domstadt. Die konferenzbegleitende Ausstellung, auf der 65 Aussteller die neuesten Trends in der Fahrzeug- und Tankstellentechnik zeigten, wurde von den mehr als 2000 Besuchern genutzt, um sich ueber die aktuellen technischen Entwicklungen zu informieren. Mit dieser aeusserst positiven Besucherresonanz von Konferenz und Fachausstellung ist die NGV `98 weltweit die bisher groesste Veranstaltung ueber alternative Fahrzeugantriebe. (orig.)

  20. Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) for Rapid Determination of Microbial Cell Lipid Content: Correlation with Gas Chromatography-Mass Spectrometry (GC-MS).

    Science.gov (United States)

    Millan-Oropeza, Aaron; Rebois, Rolando; David, Michelle; Moussa, Fathi; Dazzi, Alexandre; Bleton, Jean; Virolle, Marie-Joelle; Deniset-Besseau, Ariane

    2017-10-01

    There is a growing interest worldwide for the production of renewable oil without mobilizing agriculture lands; fast and reliable methods are needed to identify highly oleaginous microorganisms of potential industrial interest. The aim of this study was to demonstrate the relevance of attenuated total reflection (ATR) spectroscopy to achieve this goal. To do so, the total lipid content of lyophilized samples of five Streptomyces strains with varying lipid content was assessed with two classical quantitative but time-consuming methods, gas chromatography-mass spectrometry (GC-MS) and ATR Fourier transform infrared (ATR FT-IR) spectroscopy in transmission mode with KBr pellets and the fast ATR method, often questioned for its lack of reliability. A linear correlation between these three methods was demonstrated allowing the establishment of equations to convert ATR values expressed as CO/amide I ratio, into micrograms of lipid per milligram of biomass. The ATR method proved to be as reliable and quantitative as the classical GC-MS and FT-IR in transmission mode methods but faster and more reproducible than the latter since it involves far less manipulation for sample preparation than the two others. Attenuated total reflection could be regarded as an efficient fast screening method to identify natural or genetically modified oleaginous microorganisms by the scientific community working in the field of bio-lipids.

  1. Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression.

    Science.gov (United States)

    Aze, Antoine; Sannino, Vincenzo; Soffientini, Paolo; Bachi, Angela; Costanzo, Vincenzo

    2016-06-01

    Half of the human genome is made up of repetitive DNA. However, mechanisms underlying replication of chromosome regions containing repetitive DNA are poorly understood. We reconstituted replication of defined human chromosome segments using bacterial artificial chromosomes in Xenopus laevis egg extract. Using this approach we characterized the chromatin assembly and replication dynamics of centromeric alpha-satellite DNA. Proteomic analysis of centromeric chromatin revealed replication-dependent enrichment of a network of DNA repair factors including the MSH2-6 complex, which was required for efficient centromeric DNA replication. However, contrary to expectations, the ATR-dependent checkpoint monitoring DNA replication fork arrest could not be activated on highly repetitive DNA due to the inability of the single-stranded DNA binding protein RPA to accumulate on chromatin. Electron microscopy of centromeric DNA and supercoil mapping revealed the presence of topoisomerase I-dependent DNA loops embedded in a protein matrix enriched for SMC2-4 proteins. This arrangement suppressed ATR signalling by preventing RPA hyper-loading, facilitating replication of centromeric DNA. These findings have important implications for our understanding of repetitive DNA metabolism and centromere organization under normal and stressful conditions.

  2. 3rd International Arab Forensic Sciences & Forensic Medicine Conference, ASFSFM 2017: Conference Report

    Directory of Open Access Journals (Sweden)

    Abdulsallam A. Bakdash

    2017-12-01

    Full Text Available The Arab Society for Forensic Sciences and Forensic Medicine (ASFSFM at Naif Arab University for Security Sciences seeks to present the latest developments in all fields of forensic sciences through holding specialized scientific events and academic activities. This is also achieved through its periodic scientific peer-reviewed journal, the Arab Journal of Forensic Sciences and Forensic Medicine. It also seeks to promote scientific research in all fields of forensic science and forensic medicine, and seeks actively to contribute in holding scientific meetings in accordance with advanced scientific standards, including the 3rd International Arab Forensic Sciences & Forensic Medicine Conference. This important event was attended by scientists and experts from various fields of criminal and forensic sciences from both Arab and non-Arab countries. This conference was a significant scientific accomplishment that contributed to the advancement of forensic sciences and forensic medicine in the Arab world. The conference aimed, in accordance with the vision of Naif Arab University for Security Sciences, to enhance peace, security and justice in Arab societies.  Naif Arab University for Security Sciences, represented by the Arab Society for Forensic Sciences and Forensic Medicine, held the 3rd International Arab Forensic Sciences & Forensic Medicine Conference on the University's campus during the period from 21st to 23rd November 2017. The event included the participation of more than 720 experts in forensic sciences and forensic medicine from 33 countries all over the world. Experts discussed and presented the latest developments in their fields. The conference provided a creative environment for students from both local and international universities to benefit from experts and specialists, and to access the most recent research.  On behalf of His Excellency the president of Naif Arab University for Security Sciences, and the Arab Society for

  3. 1. International four seas conference. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Gougas, A K; Lemoigne, Y; Pepe-Altarelli, M; Petroff, P; Wulz, C E [eds.

    1997-07-31

    The Frist International Four Seas Conference was held in Trieste, Italy, from June 25th to July 1st, 1995. The principal aim of the Conference was to bring together physicists from the wider Balkan region along with their colleagues from the rest of the world. An overview of the current and future major European and World Physics projects (along with latest experimental results) was presented. Topics included: Physics at FNAL (collider and fixed target), LEP Physics, B and CP violation, presentations from the LHC experiments, AstroParticle Physics, Heavy Ion and Neutrino Physics. Special sessions were devoted to instrumentation projects, to spin-off applications of Particle Physics, while the final session was devoted to presentations connecting Physics and Society. (orig.)

  4. 1. International four seas conference. Proceedings

    International Nuclear Information System (INIS)

    Gougas, A.K.; Lemoigne, Y.; Pepe-Altarelli, M.; Petroff, P.; Wulz, C.E.

    1997-01-01

    The Frist International Four Seas Conference was held in Trieste, Italy, from June 25th to July 1st, 1995. The principal aim of the Conference was to bring together physicists from the wider Balkan region along with their colleagues from the rest of the world. An overview of the current and future major European and World Physics projects (along with latest experimental results) was presented. Topics included: Physics at FNAL (collider and fixed target), LEP Physics, B and CP violation, presentations from the LHC experiments, AstroParticle Physics, Heavy Ion and Neutrino Physics. Special sessions were devoted to instrumentation projects, to spin-off applications of Particle Physics, while the final session was devoted to presentations connecting Physics and Society. (orig.)

  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

    Science.gov (United States)

    Maréchal, Alexandre; Li, Ju-Mei; Ji, Xiao Ye; Wu, Ching-Shyi; Yazinski, Stephanie A; Nguyen, Hai Dang; Liu, Shizhou; Jiménez, Amanda E; Jin, Jianping; Zou, Lee

    2014-01-23

    PRP19 is a ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR). Although the role for PRP19 in splicing is well characterized, its role in the DDR remains elusive. Through a proteomic screen for proteins that interact with RPA-coated single-stranded DNA (RPA-ssDNA), we identified PRP19 as a sensor of DNA damage. PRP19 directly binds RPA and localizes to DNA damage sites via RPA, promoting RPA ubiquitylation in a DNA-damage-induced manner. PRP19 facilitates the accumulation of ATRIP, the regulatory partner of the ataxia telangiectasia mutated and Rad3-related (ATR) kinase, at DNA damage sites. Depletion of PRP19 compromised the phosphorylation of ATR substrates, recovery of stalled replication forks, and progression of replication forks on damaged DNA. Importantly, PRP19 mutants that cannot bind RPA or function as an E3 ligase failed to support the ATR response, revealing that PRP19 drives ATR activation by acting as an RPA-ssDNA-sensing ubiquitin ligase during the DDR. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Fission yeast shelterin regulates DNA polymerases and Rad3(ATR kinase to limit telomere extension.

    Directory of Open Access Journals (Sweden)

    Ya-Ting Chang

    2013-11-01

    Full Text Available Studies in fission yeast have previously identified evolutionarily conserved shelterin and Stn1-Ten1 complexes, and established Rad3(ATR/Tel1(ATM-dependent phosphorylation of the shelterin subunit Ccq1 at Thr93 as the critical post-translational modification for telomerase recruitment to telomeres. Furthermore, shelterin subunits Poz1, Rap1 and Taz1 have been identified as negative regulators of Thr93 phosphorylation and telomerase recruitment. However, it remained unclear how telomere maintenance is dynamically regulated during the cell cycle. Thus, we investigated how loss of Poz1, Rap1 and Taz1 affects cell cycle regulation of Ccq1 Thr93 phosphorylation and telomere association of telomerase (Trt1(TERT, DNA polymerases, Replication Protein A (RPA complex, Rad3(ATR-Rad26(ATRIP checkpoint kinase complex, Tel1(ATM kinase, shelterin subunits (Tpz1, Ccq1 and Poz1 and Stn1. We further investigated how telomere shortening, caused by trt1Δ or catalytically dead Trt1-D743A, affects cell cycle-regulated telomere association of telomerase and DNA polymerases. These analyses established that fission yeast shelterin maintains telomere length homeostasis by coordinating the differential arrival of leading (Polε and lagging (Polα strand DNA polymerases at telomeres to modulate Rad3(ATR association, Ccq1 Thr93 phosphorylation and telomerase recruitment.

  7. Inhibition of DNA-PKcs enhances radiosensitivity and increases the levels of ATM and ATR in NSCLC cells exposed to carbon ion irradiation.

    Science.gov (United States)

    Yang, Lina; Liu, Yuanyuan; Sun, Chao; Yang, Xinrui; Yang, Zhen; Ran, Juntao; Zhang, Qiuning; Zhang, Hong; Wang, Xinyu; Wang, Xiaohu

    2015-11-01

    Non-small cell lung cancer (NSCLC) exhibits radioresistance to conventional rays, due to its DNA damage repair systems. NSCLC may potentially be sensitized to radiation treatment by reducing those factors that continuously enhance the repair of damaged DNA. In the present study, normal lung fibroblast MRC-5 and lung cancer A549 cells were treated with NU7026 and CGK733, which are inhibitors of the DNA-dependent protein kinase catalytic subunit (PKcs) and ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR), respectively, followed by exposure to X-rays and carbon ion irradiation. The cytotoxic activity, cell survival rate, DNA damage repair ability, cell cycle arrest and apoptosis rate of the treated cells were analyzed with MTT assay, colony formation assay, immunofluorescence and flow cytometry, respectively. The transcription and translation levels of the ATM, ATR and DNA-PKcs genes were detected by reverse transcription-quantitative polymerase chain reaction and western blotting, respectively. The results indicated that the radiosensitivity and DNA repair ability of A549 cells were reduced, and the percentages of apoptotic cells and those arrested at the G 2 /M phase of the cell cycle were significantly increased, following ionizing radiation with inhibitor-pretreatment. The expression levels of ATM, ATR, DNA-PKcs and phosphorylated histone H2AX, a biomarker for DNA double-strand breaks, were all upregulated at the transcriptional or translational level in A549 cells treated with carbon ion irradiation, compared with the control and X-rays-treated cells. In addition, the treatment with 5-50 µM NU7026 or CGK733 did not produce any obvious cytotoxicity in MRC-5 cells, and the effect of the DNA-PKcs-inhibitor on enhancing the radiosensitivity of A549 cells was stronger than that observed for the ATM and ATR-inhibitor. These findings demonstrated a minor role for ATM and ATR in radiation-induced cell death, since the upregulation of

  8. ENTERPRISE IRELAND: Design for Competitive Advantage Conference

    OpenAIRE

    Dee, Peter

    2003-01-01

    A stimulating conference bringing together world leading experts on design to address the importance of brand development strategies to achieve competitive advantage. Peter Dee - Strategic Design and Marketing Consultant, specialised in the creation of brand development strategies for Enterprise Ireland’s Design Unit. Peter was responsible for the design and development of the the brand identity for the Enterprise Ireland Design for Competitive Advantage Conference in Dublin.

  9. The global non-proliferation and disarmament regime. Challenges and prospects for the future. Interview with Mr. Ambassador Jayantha Dhanapala, President of the Pugwash Conferences on Science and World Affairs, November 26, 2009

    International Nuclear Information System (INIS)

    Hautecouverture, Benjamin

    2009-01-01

    President of the Pugwash Conferences on Science and World Affairs since November 2007, Mr. Jayantha Dhanapala has had a long career as a Sri Lankan diplomat and leader in the field of international security. Among his numerous appointments, Mr. Dhanapala headed the Geneva-based UNIDIR. He chaired the widely acclaimed 1995 NPT Review and Extension Conference. He was Under-Secretary-General for Disarmament Affairs in the United Nations from 1998 to 2003. In this interview, Mr. Dhanapala gives us his thoughts about the nuclear non-proliferation regime, a few months before the 8. NPT Review Conference. (author)

  10. Application of FTIR-ATR Spectroscopy to Determine the Extent of Lipid Peroxidation in Plasma during Haemodialysis

    Directory of Open Access Journals (Sweden)

    Adam Oleszko

    2015-01-01

    Full Text Available During a haemodialysis (HD, because of the contact of blood with the surface of the dialyser, the immune system becomes activated and reactive oxygen species (ROS are released into plasma. Particularly exposed to the ROS are lipids and proteins contained in plasma, which undergo peroxidation. The main breakdown product of oxidized lipids is the malondialdehyde (MDA. A common method for measuring the concentration of MDA is a thiobarbituric acid reactive substances (TBARS method. Despite the formation of MDA in plasma during HD, its concentration decreases because it is removed from the blood in the dialyser. Therefore, this research proposes the Fourier Transform Infrared Attenuated Total Reflectance (FTIR-ATR spectroscopy, which enables determination of primary peroxidation products. We examined the influence of the amount of hydrogen peroxide added to lipid suspension that was earlier extracted from plasma specimen on lipid peroxidation with use of TBARS and FTIR-ATR methods. Linear correlation between these methods was shown. The proposed method was effective during the evaluation of changes in the extent of lipid peroxidation in plasma during a haemodialysis in sheep. A measurement using the FTIR-ATR showed an increase in plasma lipid peroxidation after 15 and 240 minutes of treatment, while the TBARS concentration was respectively lower.

  11. HMGA2 Inhibits Apoptosis through Interaction with ATR-CHK1 Signaling Complex in Human Cancer Cells

    Directory of Open Access Journals (Sweden)

    Suchitra Natarajan

    2013-03-01

    Full Text Available The non-histone chromatin binding protein high mobility group AT-hook 2 (HMGA2 is expressed in stem cells and many cancer cells, including tumor initiating cells, but not translated in normal human somatic cells. The presence of HMGA2 is correlated with advanced neoplastic disease and poor prognosis for patients. We had previously demonstrated a role of HMGA2 in DNA repair pathways. In the present study, we employed different human tumor cell models with endogenous and exogenous expression of HMGA2 and show that upon DNA damage, the presence of HMGA2 caused an increased and sustained phosphorylation of the ataxia telangiectasia and Rad3-related kinase (ATR and its downstream target checkpoint kinase 1 (CHK1. The presence of activated pCHK1Ser296 coincided with prolonged G2/M block and increased tumor cell survival, which was enhanced further in the presence of HMGA2. Our study, thus, identifies a novel relationship between the ATR-CHK1 DNA damage response pathway and HMGA2, which may support the DNA repair function of HMGA2 in cancer cells. Furthermore, our data provide a rationale for the use of inhibitors to ATR or CHK1 and HMGA2 in the treatment of HMGA2-positive human cancer cells.

  12. Validation of ATR FT-IR to identify polymers of plastic marine debris, including those ingested by marine organisms

    Science.gov (United States)

    Jung, Melissa R.; Horgen, F. David; Orski, Sara V.; Rodriguez, Viviana; Beers, Kathryn L.; Balazs, George H.; Jones, T. Todd; Work, Thierry M.; Brignac, Kayla C.; Royer, Sarah-Jeanne; Hyrenbach, David K.; Jensen, Brenda A.; Lynch, Jennifer M.

    2018-01-01

    Polymer identification of plastic marine debris can help identify its sources, degradation, and fate. We optimized and validated a fast, simple, and accessible technique, attenuated total reflectance Fourier transform infrared spectroscopy (ATR FT-IR), to identify polymers contained in plastic ingested by sea turtles. Spectra of consumer good items with known resin identification codes #1–6 and several #7 plastics were compared to standard and raw manufactured polymers. High temperature size exclusion chromatography measurements confirmed ATR FT-IR could differentiate these polymers. High-density (HDPE) and low-density polyethylene (LDPE) discrimination is challenging but a clear step-by-step guide is provided that identified 78% of ingested PE samples. The optimal cleaning methods consisted of wiping ingested pieces with water or cutting. Of 828 ingested plastics pieces from 50 Pacific sea turtles, 96% were identified by ATR FT-IR as HDPE, LDPE, unknown PE, polypropylene (PP), PE and PP mixtures, polystyrene, polyvinyl chloride, and nylon.

  13. Intersectionality in an Era of Globalization: The Implications of the U.N. World Conference against Racism for Transnational Feminist Practices

    Directory of Open Access Journals (Sweden)

    Maylei Blackwell

    2002-01-01

    Full Text Available This report examines ‘intersectionality’ as a feminist approach that significantly impacted the discourses and conversations that took place at the World Conference Against Racism and its parallel NGO Forum, in Durban, South Africa in 2001. The term ‘intersectionality’ refers to the links between gender discrimination, homophobia, racism and class exploitation. As women of color feminist scholars positioned within the geographic territories of the U.S., the authors specifically highlight key issues and social movement trends that were ignored by the U.S. media. Alternatively, this report focuses on how the conference framework of ‘related intolerance’ allowed for broader conversations on how racism is exacerbated by globalization as well as on multiple oppressions in relation to sexual orientation and sexual rights. The authors emphasize how an insistence on discussing the significance of race and gender as well as class, in the context of neo-liberal capitalism, puts important new coordinates on the maps of transnational feminist organizing and anti-globalization movement.

  14. 2nd Tourism Postdisciplinarity Conference

    DEFF Research Database (Denmark)

    Following the noted success of the 1st international conference on postdisciplinary approaches to tourism studies (held in Neuchatel, Switzerland, 19-22 June, 2013), we are happy to welcome you to the 2nd Tourism Postdisciplinarity Conference. Postdisciplinarity surpasses the boundaries...... of study less embedded in that system of thought. Postdisciplinarity is an epistemological endeavour that speaks of knowledge production and the ways in which the world of physical and social phenomena can be known. It is also an ontological discourse as it concerns what we call ‘tourism...

  15. Bridging Services: Drug Abuse, Human Services and the Therapeutic Community. Proceedings of the World Conference of Therapeutic Communities (9th, San Francisco, California, September 1-6, 1985).

    Science.gov (United States)

    Acampora, Alfonso P., Ed.; Nebelkopf, Ethan, Ed.

    The World Federation of Therapeutic Communities is an international association of drug treatment centers that use the "Therapeutic Community" (TC) to combat chemical dependency and drug addiction. Their 1985 conference focused on bridging services between the TC and the traditional human service systems. A total of 85 separate papers were…

  16. “Il Dolore, il Lutto, la Gloria. Rappresentazioni Fotografiche della Grande Guerra fra Pubblico e Privato, 1914-1940” a Conference on the First World War and its Representations

    Directory of Open Access Journals (Sweden)

    Gianluigi Di Giangirolamo

    2016-11-01

    Full Text Available On the occasion of the First World War Centenary, the Department for Cultural Heritage of the University of Bologna in Ravenna together with the SISF Italian Society for the Study on photography, promoted the conference Il dolore, il lutto, la gloria. Rappresentazioni fotografiche della grande guerra fra pubblico e privato, 1914-1940 between 26-28 May, 2016. The conference was organised in collaboration with the University of Padova, the Fundation of Historical Studies Filippo Turati of Florence and the Institute of the History of Italian Risorgimento of Rome.

  17. Assessment of winter air pollution episodes using long-range transport modeling in Hangzhou, China, during World Internet Conference, 2015.

    Science.gov (United States)

    Ni, Zhi-Zhen; Luo, Kun; Zhang, Jun-Xi; Feng, Rui; Zheng, He-Xin; Zhu, Hao-Ran; Wang, Jing-Fan; Fan, Jian-Ren; Gao, Xiang; Cen, Ke-Fa

    2018-05-01

    A winter air pollution episode was observed in Hangzhou, South China, during the Second World Internet Conference, 2015. To study the pollution characteristics and underlying causes, the Weather Research and Forecasting with Chemistry model was used to simulate the spatial and temporal evolution of the pollution episode from December 8 to 19, 2015. In addition to scenario simulations, analysis of the atmospheric trajectory and synoptic weather conditions were also performed. The results demonstrated that control measures implemented during the week preceding the conference reduced the fine particulate matter (PM 2.5 ) pollution level to some extent, with a decline in the total PM 2.5 concentration in Hangzhou of 15% (7%-25% daily). Pollutant long-range transport, which occurred due to a southward intrusion of strong cold air driven by the Siberia High, led to severe pollution in Hangzhou on December 15, 2015, accounting for 85% of the PM 2.5 concentration. This study provides new insights into the challenge of winter pollution prevention in Hangzhou. For adequate pollution prevention, more regional collaborations should be fostered when creating policies for northern China. Copyright © 2018 Elsevier Ltd. All rights reserved.

  18. Roles of nibrin and ATM/ATR kinases on the G2 checkpoint under endogenous or radio-induced DNA damage

    Directory of Open Access Journals (Sweden)

    Katherine Marcelain

    2005-01-01

    Full Text Available Checkpoint response to DNA damage involves the activation of DNA repair and G2 lengthening subpathways. The roles of nibrin (NBS1 and the ATM/ATR kinases in the G2 DNA damage checkpoint, evoked by endogenous and radio-induced DNA damage, were analyzed in control, A-T and NBS lymphoblast cell lines. Short-term responses to G2 treatments were evaluated by recording changes in the yield of chromosomal aberrations in the ensuing mitosis, due to G2 checkpoint adaptation, and also in the duration of G2 itself. The role of ATM/ATR in the G2 checkpoint pathway repairing chromosomal aberrations was unveiled by caffeine inhibition of both kinases in G2. In the control cell lines, nibrin and ATM cooperated to provide optimum G2 repair for endogenous DNA damage. In the A-T cells, ATR kinase substituted successfully for ATM, even though no G2 lengthening occurred. X-ray irradiation (0.4 Gy in G2 increased chromosomal aberrations and lengthened G2, in both mutant and control cells. However, the repair of radio-induced DNA damage took place only in the controls. It was associated with nibrin-ATM interaction, and ATR did not substitute for ATM. The absence of nibrin prevented the repair of both endogenous and radio-induced DNA damage in the NBS cells and partially affected the induction of G2 lengthening.

  19. 10. international mouse genome conference

    Energy Technology Data Exchange (ETDEWEB)

    Meisler, M.H.

    1996-12-31

    Ten years after hosting the First International Mammalian Genome Conference in Paris in 1986, Dr. Jean-Louis Guenet presided over the Tenth Conference at the Pasteur Institute, October 7--10, 1996. The 1986 conference was a satellite to the Human Gene Mapping Workshop and had approximately 50 attendees. The 1996 meeting was attended by 300 scientists from around the world. In the interim, the number of mapped loci in the mouse increased from 1,000 to over 20,000. This report contains a listing of the program and its participants, and two articles that review the meeting and the role of the laboratory mouse in the Human Genome project. More than 200 papers were presented at the conference covering the following topics: International mouse chromosome committee meetings; Mutant generation and identification; Physical and genetic maps; New technology and resources; Chromatin structure and gene regulation; Rate and hamster genetic maps; Informatics and databases; and Quantitative trait analysis.

  20. Differential Processing of Low and High LET Radiation Induced DNA Damage: Investigation of Switch from ATM to ATR Signaling

    Science.gov (United States)

    Saha, Janapriya; Wang, Minli; Hada, Megumi; Cucinotta, Francis A.

    2011-01-01

    The members of the phosphatidylinositol kinase-like kinase family of proteins namely ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) are directly responsible for the maintenance of genomic integrity by mounting DDR through signaling and facilitating the recruitment of repair factors at the sites of DNA damage along with coordinating the deployment of cell cycle checkpoints to permit repair by phosphorylating Checkpoint kinase Chk1, Chk2 and p53. High LET radiation from GCR (Galactic Cosmic Rays) consisting mainly of protons and high energy and charged (HZE) particles from SPE (Solar Particle Event) pose a major health risk for astronauts on their space flight missions. The determination of these risks and the design of potential safeguards require sound knowledge of the biological consequences of lesion induction and the capability of the cells to counter them. We here strive to determine the coordination of ATM and ATR kinases at the break sites directly affecting checkpoint signaling and DNA repair and whether differential processing of breaks induced by low and high LET radiation leads to possible augmentation of swap of these damage sensors at the sites of DNA damage. Exposure of cells to IR triggers rapid autophosphorylation of serine-1981 that causes dimer dissociation and initiates monomer formation of ATM. ATM kinase activity depends on the disruption of the dimer, which allows access and phosphorylation of downstream ATM substrates like Chk2. Evidence suggests that ATM is activated by the alterations in higher-order chromatin structure although direct binding of ATM to DSB ends may be a crucial step in its activation. On the other hand, in case of ATR, RPA (replication protein A)-coated ssDNA (single-stranded DNA) generated as a result of stalled DNA replication or during processing of chromosomal lesions is crucial for the localization of ATR to sites of DNA damage in association with ATR-interacting protein (ATRIP). Although the

  1. Monitoring of biofilm growth using ATR-leaky mode spectroscopy

    International Nuclear Information System (INIS)

    Leitz, M.; Franke, H.; Grattan, K.T.V.; Tamachkiarow, A.

    2002-01-01

    An approach to the in situ monitoring of biofilm formation using the technique of ATR-leaky mode spectroscopy is given as an example for the case of Cytophaga. The biofilm growth was studied on an aluminium layer and on a bilayer of the hydrogel agarose on aluminium. This metal was chosen because of its chemical stability in aqueous systems. The spectra obtained have been recorded using a flow cell to contain the suspension and nutrients over a period of several days. In the case considered using a prism surface coated with agarose, the experiments were performed by breeding in an incubator. (author)

  2. Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5- a ]pyrazines as ATR Inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Barsanti, Paul A; Aversa, Robert J.; Jin, Xianming; Pan, Yue; Lu, Yipin; Elling, Robert; Jain, Rama; Knapp, Mark; Lan, Jiong; Lin, Xiaodong; Rudewicz, Patrick; Sim, Janet; Taricani, Lorena; Thomas, George; Xiao, Linda; Yue, Qin (Novartis)

    2015-01-08

    A saturation strategy focused on improving the selectivity and physicochemical properties of ATR inhibitor HTS hit 1 led to a novel series of highly potent and selective tetrahydropyrazolo[1,5-a]pyrazines. Use of PI3Kα mutants as ATR crystal structure surrogates was instrumental in providing cocrystal structures to guide the medicinal chemistry designs. Detailed DMPK studies involving cyanide and GSH as trapping agents during microsomal incubations, in addition to deuterium-labeled compounds as mechanistic probes uncovered the molecular basis for the observed CYP3A4 TDI in the series.

  3. Internet conferences in glycobiology.

    Science.gov (United States)

    Hardy, B J; Doughty, S W; Parretti, M F; Tennison, J; Wilson, I

    1997-09-01

    In this article we describe recent activities in the use of electronic conferencing in glycobiology focusing on our experiences with the organization and development of the Second Electronic Glycoscience Conference (EGC-2), which was held on the Internet and World Wide Web in September 1996. EGC-2 involved the presentation and discussion of scientific research results in a virtual conferencing environment which incorporated virtual replicas of many activities usually observed at a physical conference in addition to features unique to the electronic medium. Highlights of the scientific program and technical developments in the design and use of these facilities are briefly described. EGC-3 will be held in October 1997.

  4. Reflections on "Real-World" Community Psychology

    Science.gov (United States)

    Wolff, Tom; Swift, Carolyn

    2008-01-01

    Reflections on the history of real-world (applied) community psychologists trace their participation in the field's official guild, the Society for Community Research and Action (SCRA), beginning with the Swampscott Conference in 1965 through the current date. Four benchmarks are examined. The issues these real-world psychologists bring to the…

  5. Cadmium depletion impacts on hardening neutron spectrum for advanced fuel testing in ATR

    International Nuclear Information System (INIS)

    Chang, Gray S.

    2011-01-01

    For transmuting long-lived isotopes contained in spent nuclear fuel into shorter-lived fission products effectively is in a fast neutron spectrum reactor. In the absence of a fast spectrum test reactor in the United States of America (USA), initial irradiation testing of candidate fuels can be performed in a thermal test reactor that has been modified to produce a test region with a hardened neutron spectrum. A test region is achieved with a Cadmium (Cd) filter which can harden the neutron spectrum to a spectrum similar (although still somewhat softer) to that of the liquid metal fast breeder reactor (LMFBR). A fuel test loop with a Cd-filter has been installed within the East Flux Trap (EFT) of the Advanced Test Reactor (ATR) at the Idaho National Laboratory (INL). A detailed comparison analyses between the cadmium (Cd) filter hardened neutron spectrum in the ATR and the LMFBR fast neutron spectrum have been performed using MCWO. MCWO is a set of scripting tools that are used to couple the Monte Carlo transport code MCNP with the isotope depletion and buildup code ORIGEN-2.2. The MCWO-calculated results indicate that the Cd-filter can effectively flatten the Rim-Effect and reduce the linear heat rate (LHGR) to meet the advanced fuel testing project requirements at the beginning of irradiation (BOI). However, the filtering characteristics of Cd as a strong absorber quickly depletes over time, and the Cd-filter must be replaced for every two typical operating cycles within the EFT of the ATR. The designed Cd-filter can effectively depress the LHGR in experimental fuels and harden the neutron spectrum enough to adequately flatten the Rim-Effect in the test region. (author)

  6. The Role of Science in the Information Society asserted in CERN conference

    CERN Multimedia

    2004-01-01

    A key objective of the RSIS conference (CERN, 8-9 December) was to respond to a challenge made by the UN Secretary-General, Kofi Annan, last March, when he called on the world's scientists to work with the United Nations to extend the benefits of modern science to developing countries. In hosting the Role of Science in the Information Society (RSIS) conference, CERN took a bold step forward into the policy arena. The conference, which was organised jointly by CERN, UNESCO, the International Council for Science, and the Third World Academy of Sciences, was held at CERN on 8-9 December as a Summit Event to the first phase of the World Summit on the Information Society (Geneva, 10-12 December). "This event has helped to develop a vision for how information and communication technologies can be applied for the greater benefit of all," said Luciano Maiani, Director General of CERN until the end of 2003, who gave a summary of the conference. The globalisation of the information society has the...

  7. The Conference Proceedings of the 2001 Air Transport Research Society (ATRS) of the WCTR Society. Volume 3

    Science.gov (United States)

    Lee, Yeong-Heok (Editor); Bowen, Brent D. (Editor); Tarry, Scott E. (Editor)

    2001-01-01

    The papers presented at this conference include: 1) The Global Airline Company: Agent of Market Power or Competition? 2) Airport Pavement Management; 3) Reservation System Providers and the Impact of Codeshare Arrangements on Screen Display; 4) Strategic Classification of Current Airline Alliances and Examination of Critical Factors Involving the Formations - an Explorative Perspective; 5) Airport Privatization Policy and Performance Measurement in Korea; 6) Pilot and Air Traffic Controller Relationships: The Role of Interdependence and Relative Influence; 7) Liberalization of Air Cargo Services: Background and an Economic Analysis; 8) The Implication of Hub and Spoke Network on the Airline Alliance Strategy.

  8. RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.

    Science.gov (United States)

    Manfrini, Nicola; Trovesi, Camilla; Wery, Maxime; Martina, Marina; Cesena, Daniele; Descrimes, Marc; Morillon, Antonin; d'Adda di Fagagna, Fabrizio; Longhese, Maria Pia

    2015-02-01

    Eukaryotic cells respond to DNA double-strand breaks (DSBs) by activating a checkpoint that depends on the protein kinases Tel1/ATM and Mec1/ATR. Mec1/ATR is activated by RPA-coated single-stranded DNA (ssDNA), which arises upon nucleolytic degradation (resection) of the DSB. Emerging evidences indicate that RNA-processing factors play critical, yet poorly understood, roles in genomic stability. Here, we provide evidence that the Saccharomyces cerevisiae RNA decay factors Xrn1, Rrp6 and Trf4 regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA. The lack of Xrn1 inhibits ssDNA generation at the DSB by preventing the loading of the MRX complex. By contrast, DSB resection is not affected in the absence of Rrp6 or Trf4, but their lack impairs the recruitment of RPA, and therefore of Mec1, to the DSB. Rrp6 and Trf4 inactivation affects neither Rad51/Rad52 association nor DSB repair by homologous recombination (HR), suggesting that full Mec1 activation requires higher amount of RPA-coated ssDNA than HR-mediated repair. Noteworthy, deep transcriptome analyses do not identify common misregulated gene expression that could explain the observed phenotypes. Our results provide a novel link between RNA processing and genome stability. © 2014 The Authors.

  9. 7th International Conference of Political Economy

    OpenAIRE

    BEKEN, Gülçin

    2016-01-01

    Abstract. In this study, the 7th International Conference of Political Economy in İstanbul was evaluated. This year it  was organized by Marmara University Faculty of Economics and Batman University Faculty of Economics and Administrative Sciences with the cooperation of their international supporters all over the world. These conference series are said to be successful to bring all the scholars, academicians, students, and volunteers who are interested in political economy. Starting from 200...

  10. Applications of diamond crystal ATR FTIR spectroscopy to the characterization of ambers.

    Science.gov (United States)

    Guiliano, Michel; Asia, Laurence; Onoratini, Gérard; Mille, Gilbert

    2007-08-01

    Diamond crystal ATR FTIR spectroscopy is a rapid technique with virtually no sample preparation which requires small sample amounts and showed potential in the study of ambers. FTIR spectra of ambers present discriminating patterns and can be used to distinguish amber from immature resins as copal, to determine local or Baltic origin of archaeological ambers and to detect most of the falsifications encountered in the amber commercialisation.

  11. Seventh Scandinavian Conference on Artificial Intelligence

    DEFF Research Database (Denmark)

    Lund, Henrik Hautop; Mayoh, Brian Henry; Perram, John

    2001-01-01

    The book covers the seventh Scandinavian Conference on Artificial Intelligence, held at the Maersk Mc-Kinney Moller Institute for Production Technology at the University of Southern Denmark during the period 20-21 February, 2001. It continues the tradition established by SCAI of being one...... of the most important regional AI conferences in Europe, attracting high quality submissions from Scandinavia and the rest of the world, including the Baltic countries. The contents include robotics, sensor/motor intelligence, evolutionary robotics, behaviour-based systems, multi-agent systems, applications...

  12. International Conference on Theoretical and Computational Physics

    CERN Document Server

    2016-01-01

    Int'l Conference on Theoretical and Computational Physics (TCP 2016) will be held from August 24 to 26, 2016 in Xi'an, China. This Conference will cover issues on Theoretical and Computational Physics. It dedicates to creating a stage for exchanging the latest research results and sharing the advanced research methods. TCP 2016 will be an important platform for inspiring international and interdisciplinary exchange at the forefront of Theoretical and Computational Physics. The Conference will bring together researchers, engineers, technicians and academicians from all over the world, and we cordially invite you to take this opportunity to join us for academic exchange and visit the ancient city of Xi’an.

  13. 6th World Conference on 21st Century Mathematics

    CERN Document Server

    Choudary, ADR; Waldschmidt, Michel

    2015-01-01

    Numerous well-presented and important papers from the conference are gathered in the proceedings for the purpose of pointing directions for useful future research in diverse areas of mathematics including algebraic geometry, analysis, commutative algebra, complex analysis, discrete mathematics, dynamical systems, number theory and topology. Several papers on computational and applied mathematics such as wavelet analysis, quantum mechanics, piecewise linear modeling, cosmological models of super symmetry, fluid dynamics, interpolation theory, optimization, ergodic theory and games theory are also presented.

  14. XXII Fluid Mechanics Conference (KKMP2016)

    International Nuclear Information System (INIS)

    2016-01-01

    This Journal of Physics: Conference Series contains papers that have been presented at XXII Fluid Mechanics Conference (XXII FMC) held in Słok near Bełchatów in Poland during llth-14th September of 2016. The Conference is organized by Wrocław University of Science and Technology, Polish Academy of Sciences - Committee of Mechanics and Foun-dation for Development of Wroclaw University of Science and Technology. Let us recall some historical facts: Fluid Mechanics Conferences have been taking place every two years since 1974, which makes a total of forty-two years. The goal of this conference is to provide a forum for exposure and exchange of ideas, methods and results in fluid mechanics. We have already met in Bełchatów 10 years ago (XVII KKMP). It was a successful meeting. Since then the National Conference on Fluid Mechanics has changed title and has started to be named Fluid Mechanics Conference in the hopes that it will attract more participants from other countries. English became the Conference's first language and we started to invite world leading scientists - working in the field of fluid mechanics. At the 2006 conference we hosted for the first time prof. Keith Moffatt from the Cambridge University. In this year prof. Moffatt once again promised us to arrive to Bełchatów. The whole fluid mechanics community celebrates 9 2 anniversary of his birthday. So let us also wish happy anniversary to prof. Moffatt. In the mean time we had to pay last respects to our collages. Prof. Prosnak who is regarded as a founder of the Notational Conference on Fluid Mechanics and is well known through his books. Prof. Puzyrewski who was present at all conferences so far. He was providing via his discussions a special value to these conferences, and our colleague prof. Konrad Bajer who was intended to be the organizer and host of the present conference. Short memories to them will be given during the opening ceremony. Conference topics include, but are not limited

  15. Structural Analysis of Spiropyran Polimers using ATR Spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Delgado Macui, R; Rojas Lopez, M; Gayou, V L; Orduna Diaz, A [Centro de Investigacion en BiotecnologIa Aplicada del IPN, San Juan de los Molinos km. 1.5 Tepetitla de Lardizabal, A.P. 90700, Tlaxcala (Mexico)

    2006-01-01

    We have used infrared spectroscopy in attenuated total reflection (ATR) mode to analyze the interactions between the polymeric base and solvent with a photochromic material (spyropiran). We used cellulose acetate as polymeric base and the spyropiran; 1,3,3 trimethyl indoline-5-nitro benzopyrane. Thin films with different weight concentrations of SP were deposited in the polymeric base. The infrared spectra show bands whose frequencies are associated to several molecular bondings. It was observed a decreasing in intensity of absorbance for C = O stretching mode of the acetate group at 1720 cm{sup -1} and for C = C stretching mode for the main chain at 823 and 982 cm{sup -1} both associated to the presence of SP in polymeric films.

  16. Analysis code for large rupture accidents in ATR. SENHOR/FLOOD/HEATUP

    International Nuclear Information System (INIS)

    1997-08-01

    In the evaluation of thermo-hydraulic transient change, the behavior of core reflooding and the transient change of fuel temperature in the events which are classified in large rupture accidents of reactor coolant loss, that is the safety evaluation event of the ATR, the analysis codes for thermo-hydraulic transient change at the time of large rupture SENHOR, for core reflooding characteristics FLOOD and for fuel temperature HEATUP are used, respectively. The analysis code system for loss of coolant accident comprises the analysis code for thermo-hydraulic transient change at the time of medium and small ruptures LOTRAC in addition to the above three codes. Based on the changes with time lapse of reactor thermal output and steam drum pressure obtained by the SENHOR, average reflooding rate is analyzed by the FLOOD, and the time of starting the turnaround of fuel cladding tube temperature and the heat transfer rate after the turnaround are determined. Based on these data, the detailed temperature change of fuel elements is analyzed by the HEATUP, and the highest temperature and the amount of oxidation of fuel cladding tubes are determined. The SENHOR code, the FLOOD code and the HEATUP code and various models for these codes are explained. The example of evaluation and the sensitivity analysis of the ATR plant are reported in the Appendix. (K.I.)

  17. Analysis of European honeybee (Apis mellifera) wings using ATR-FTIR and Raman spectroscopy: A pilot study

    Czech Academy of Sciences Publication Activity Database

    Machovič, Vladimír; Lapčák, L.; Havelcová, Martina; Borecká, Lenka; Novotná, M.; Novotná, M.; Javůrková, I.; Langrová, I.; Hájková, Š.; Brožová, A.; Titěra, D.

    2017-01-01

    Roč. 48, č. 1 (2017), s. 22-29 ISSN 1211-3174 Institutional support: RVO:67985891 Keywords : honeybee wings * ATR-FTIR * Raman spectroscopy * protein * lipid * chitin Subject RIV: CB - Analytical Chemistry, Separation OBOR OECD: Analytical chemistry

  18. Meetings on atomic energy. V.26, no.4. A quarterly world-wide list of conferences, exhibitions and training courses in atomic energy

    International Nuclear Information System (INIS)

    Salvini Plawen, S.

    1994-10-01

    This quarterly list comprises conferences, exhibitions and training courses that have been planned on subjects directly or indirectly related to nuclear energy and its peaceful uses. The designation of countries or territories and the arrangement of material in this publication should not be considered as implying any endorsement or other judgement by the Agency regarding the legal status of any country or territory, or of its authorities, or in respect of the delimitation of its boundaries. The list has a world-wide distribution and is intended to be comprehensive within the field of nuclear science

  19. Meetings on atomic energy. V.26, no.2. A quarterly world-wide list of conferences, exhibitions and training courses in atomic energy

    International Nuclear Information System (INIS)

    Salvini Plawen, S.

    1994-04-01

    This quarterly list comprises conferences, exhibitions and training courses that have been planned on subjects directly or indirectly related to nuclear energy and its peaceful uses. The designation of countries or territories and the arrangement of material in this publication should not be considered as implying any endorsement or other judgement by the Agency regarding the legal status of any country or territory, or of its authorities, or in respect of the delimitation of its boundaries. The list has a world-wide distribution and is intended to be comprehensive within the field of nuclear science

  20. Meetings on atomic energy. V.26, no.3. A quarterly world-wide list of conferences, exhibitions and training courses in atomic energy

    International Nuclear Information System (INIS)

    Salvini Plawen, S.

    1994-07-01

    This quarterly list comprises conferences, exhibitions and training courses that have been planned on subjects directly or indirectly related to nuclear energy and its peaceful uses. The designation of countries or territories and the arrangement of material in this publication should not be considered as implying any endorsement or other judgement by the Agency regarding the legal status of any country or territory, or of its authorities, or in respect of the delimitation of its boundaries. The list has a world-wide distribution and is intended to be comprehensive within the field of nuclear science

  1. Proceedings of the WIN-Global 2008 conference

    International Nuclear Information System (INIS)

    2008-01-01

    WiN-France hosted the 16. WIN-Global conference May 26-30, 2008, in Marseille, France. The conference was attended by over 150 delegates, representing 30 countries. Canadian participants, from many diverse backgrounds, attended the annual conference from AECL, Bruce Power, CNSC, NB Power and OPG. The theme: Maintaining Key Competencies, Arising Key Competencies for Nuclear Energy: A Challenge and Opportunity for Diversity Development, emphasized the challenges ahead in providing a skilled workforce for the nuclear renaissance, as new build projects and a vast number of retirements are expected around the world within the next 5 years. The conference addressed such questions as 'How will nuclear, attract, develop and retain staff?' A technical tour of Marcoule invited conference attendees to visit one of: Atalante, a high level nuclear chemistry laboratory; Phenix, a fast breeding research reactor; or AVM, a vitrification plant. A subsequent technical tour visited Cadarache providing the opportunity to view ITER, the international fusion research project

  2. Proceedings of the WIN-Global 2008 conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    WiN-France hosted the 16. WIN-Global conference May 26-30, 2008, in Marseille, France. The conference was attended by over 150 delegates, representing 30 countries. Canadian participants, from many diverse backgrounds, attended the annual conference from AECL, Bruce Power, CNSC, NB Power and OPG. The theme: Maintaining Key Competencies, Arising Key Competencies for Nuclear Energy: A Challenge and Opportunity for Diversity Development, emphasized the challenges ahead in providing a skilled workforce for the nuclear renaissance, as new build projects and a vast number of retirements are expected around the world within the next 5 years. The conference addressed such questions as 'How will nuclear, attract, develop and retain staff?' A technical tour of Marcoule invited conference attendees to visit one of: Atalante, a high level nuclear chemistry laboratory; Phenix, a fast breeding research reactor; or AVM, a vitrification plant. A subsequent technical tour visited Cadarache providing the opportunity to view ITER, the international fusion research project.

  3. Proceedings of the WIN-Global 2008 conference

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    WiN-France hosted the 16. WIN-Global conference May 26-30, 2008, in Marseille, France. The conference was attended by over 150 delegates, representing 30 countries. Canadian participants, from many diverse backgrounds, attended the annual conference from AECL, Bruce Power, CNSC, NB Power and OPG. The theme: Maintaining Key Competencies, Arising Key Competencies for Nuclear Energy: A Challenge and Opportunity for Diversity Development, emphasized the challenges ahead in providing a skilled workforce for the nuclear renaissance, as new build projects and a vast number of retirements are expected around the world within the next 5 years. The conference addressed such questions as 'How will nuclear, attract, develop and retain staff?' A technical tour of Marcoule invited conference attendees to visit one of: Atalante, a high level nuclear chemistry laboratory; Phenix, a fast breeding research reactor; or AVM, a vitrification plant. A subsequent technical tour visited Cadarache providing the opportunity to view ITER, the international fusion research project.

  4. 2nd International Conference on Intelligent Computing and Applications

    CERN Document Server

    Dash, Subhransu; Das, Swagatam; Panigrahi, Bijaya

    2017-01-01

    Second International Conference on Intelligent Computing and Applications was the annual research conference aimed to bring together researchers around the world to exchange research results and address open issues in all aspects of Intelligent Computing and Applications. The main objective of the second edition of the conference for the scientists, scholars, engineers and students from the academia and the industry is to present ongoing research activities and hence to foster research relations between the Universities and the Industry. The theme of the conference unified the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in computational intelligence and bridges theoretical research concepts with applications. The conference covered vital issues ranging from intelligent computing, soft computing, and communication to machine learning, industrial automation, process technology and robotics. This conference also provided variety of opportunities for ...

  5. International Conference on Materials Science and Technology (ICMST 2012)

    Science.gov (United States)

    Joseph, Ginson P.

    2015-02-01

    FROM THE CONVENOR'S DESK The Department of Physics, St. Thomas College Pala, is highly privileged to organize an International Conference on Materials Science and Technology (ICMST 2012) during 10-14 June 2012, and as Convenor of the conference it is with legitimate pride and immense gratitude to God that I remember the most enthusiastic responses received for this from scientists all over the world. In a time of tremendous revolutionary changes in Materials Science and Technology, it is quite in keeping with the tradition of a pioneering institute that St. Thomas College is, to have risen to the occasion to make this conference a reality. We have no doubt that this proved to be a historic event, a real breakthrough, not only for us the organizers but also for all the participants. A conference of this kind provides a nonpareil, a distinctly outstanding platform for the scholars, researchers and the scientists to discuss and share ideas with delegates from all over the world. This had been most fruitful to the participants in identifying new collaborations and strengthening existing relations. That experts of diverse disciplines from across the world were sitting under one roof for five days, exchanging views and sharing findings, was a speciality of this conference. The event has evoked excellent responses from all segments of the Materials Science community worldwide. 600 renowned scholars from 28 countries participated in this. We were uniquely honoured to have Prof. C.N.R. Rao, Chairman, Scientific Advisory Council to the Prime Minister of India, to inaugurate this conference. May I take this opportunity to thank all those who have contributed their valuable share, diverse in tone and nature, in the making of this conference. My whole hearted gratitude is due to the international and national members of the advisory committee for their valuable guidance and involvement. I place on record my heartfelt gratitude to our sponsors. I am sure that this conference has

  6. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 1 + 2 + 3 from track "Building Retrofit".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 1 + 2 + 3 from track "Building Retrofit"....

  7. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 31 + 32 + 33 from track "Building Performance".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 31 + 32 + 33 from track "Building Performance"....

  8. Archaeology and the World Heritage Convention

    Directory of Open Access Journals (Sweden)

    Henry Cleere

    2003-10-01

    Full Text Available International efforts to designate outstanding examples of the world's cultural and natural heritage began after the Second World War. The World Heritage Convention was signed at the General Conference of UNESCO in 1972 and the first cultural sites were selected in 1978. Now over 600 have been inscribed on the World Heritage List. The author, who is an honorary visiting professor at the Institute, acted as an advisor to the World Heritage Committee from 1992 to 2002 and here describes how the Convention came into being and discusses the representation of archaeological sites on the List.

  9. Student Support for EIPBN 2010 Conference

    Energy Technology Data Exchange (ETDEWEB)

    Reginald C. Farrow

    2011-03-11

    The 54th International Conference on Electron, Ion and Photon Beam Technology and Nanofabrication, 2010, held at the Egan Convention Center and Hilton in Anchorage, Alaska, June 1 to 4, 2010 was a great success in large part because financial support allowed robust participation from students. The conference brought together 444 engineers and scientists from industries and universities from all over the world to discuss recent progress and future trends. Among the emerging technologies that are within the scope of EIPBN is Nanofabrication for Energy Sources along with nanofabrication for the realization of low power integrated circuits. Every year, EIPBN provides financial support for students to attend the conference.The students gave oral and poster presentations of their research and many published peer reviewed articles in a special conference issue of the Journal of Vacuum Science and Technology B. The Department of Energy Office of Basic Energy Sciences supported 20 students from US universities with a $15,000.

  10. Study of consumer fireworks post-blast residues by ATR-FTIR.

    Science.gov (United States)

    Martín-Alberca, Carlos; Zapata, Félix; Carrascosa, Héctor; Ortega-Ojeda, Fernando E; García-Ruiz, Carmen

    2016-03-01

    Specific analytical procedures are requested for the forensic analysis of pre- and post-blast consumer firework samples, which present significant challenges. Up to date, vibrational spectroscopic techniques such as Fourier transform infrared spectroscopy (FTIR) have not been tested for the analysis of post-blast residues in spite of their interesting strengths for the forensic field. Therefore, this work proposes a simple and fast procedure for the sampling and analysis of consumer firework post-blast residues by a portable FTIR instrument with an Attenuated Total Reflection (ATR) accessory. In addition, the post-blast residues spectra of several consumer fireworks were studied in order to achieve the identification of their original chemical compositions. Hence, this work analysed 22 standard reagents usually employed to make consumer fireworks, or because they are related to their combustion products. Then, 5 different consumer fireworks were exploded, and their residues were sampled with dry cotton swabs and directly analysed by ATR-FTIR. In addition, their pre-blast fuses and charges were also analysed in order to stablish a proper comparison. As a result, the identification of the original chemical compositions of the post-blast samples was obtained. Some of the compounds found were potassium chlorate, barium nitrate, potassium nitrate, potassium perchlorate or charcoal. An additional study involving chemometric tools found that the results might greatly depend on the swab head type used for the sampling, and its sampling efficiency. The proposed procedure could be used as a complementary technique for the analysis of consumer fireworks post-blast residues. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. SIGEF Conference

    CERN Document Server

    Terceño-Gómez, Antonio; Ferrer-Comalat, Joan; Merigó-Lindahl, José; Linares-Mustarós, Salvador

    2015-01-01

    This book is a collection of selected papers presented at the SIGEF conference, held at the Faculty of Economics and Business of the University of Girona (Spain), 06-08 July, 2015. This edition of the conference has been presented with the slogan “Scientific methods for the treatment of uncertainty in social sciences”. There are different ways for dealing with uncertainty in management. The book focuses on soft computing theories and their role in assessing uncertainty in a complex world. It gives a comprehensive overview of quantitative management topics and discusses some of the most recent developments in all the areas of business and management in soft computing including Decision Making, Expert Systems and Forgotten Effects Theory, Forecasting Models, Fuzzy Logic and Fuzzy Sets, Modelling and Simulation Techniques, Neural Networks and Genetic Algorithms and Optimization and Control. The book might be of great interest for anyone working in the area of management and business economics and might be es...

  12. Final report on the Copper Mountain conference on multigrid methods

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-10-01

    The Copper Mountain Conference on Multigrid Methods was held on April 6-11, 1997. It took the same format used in the previous Copper Mountain Conferences on Multigrid Method conferences. Over 87 mathematicians from all over the world attended the meeting. 56 half-hour talks on current research topics were presented. Talks with similar content were organized into sessions. Session topics included: fluids; domain decomposition; iterative methods; basics; adaptive methods; non-linear filtering; CFD; applications; transport; algebraic solvers; supercomputing; and student paper winners.

  13. 38th International Conference on High Energy Physics

    CERN Document Server

    2016-01-01

    The U.S. particle physics community is proud to host the 38th ICHEP conference in Chicago from the 3rd to the 10th August 2016. ICHEP is a focal point of the field of particle physics, brining together leading experimentalists and theorists of the world. It was first held in 1950, and is biennial since 1960. At ICHEP all areas of particle physics including neutrino, flavor, astro-particle and new physics beyond the Standard Model share the exciting results obtained in the field and exchange views among all experimental and theoretical scientists of the world including students and postodcs. The conference will consist of parallel and invited plenary sessions. A poster session will emphasize the work of young students.

  14. Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

    Directory of Open Access Journals (Sweden)

    Stephanie Munk

    2017-10-01

    Full Text Available The mechanisms that protect eukaryotic DNA during the cumbersome task of replication depend on the precise coordination of several post-translational modification (PTM-based signaling networks. Phosphorylation is a well-known regulator of the replication stress response, and recently an essential role for SUMOs (small ubiquitin-like modifiers has also been established. Here, we investigate the global interplay between phosphorylation and SUMOylation in response to replication stress. Using SUMO and phosphoproteomic technologies, we identify thousands of regulated modification sites. We find co-regulation of central DNA damage and replication stress responders, of which the ATR-activating factor TOPBP1 is the most highly regulated. Using pharmacological inhibition of the DNA damage response kinases ATR and ATM, we find that these factors regulate global protein SUMOylation in the protein networks that protect DNA upon replication stress and fork breakage, pointing to integration between phosphorylation and SUMOylation in the cellular systems that protect DNA integrity.

  15. Radiation Measurements Laboratory (RML) calibration and assessment of the ATR SPING-3 stack effluent monitor

    International Nuclear Information System (INIS)

    Koeppen, L.D.; Rogers, J.W.; Simpson, O.D.

    1983-12-01

    An evaluation, calibration and assessment of the Eberline SPING-3 ATR stack effluent monitor was conducted. This unit which monitors particulate, iodine and noble gas effluents was producing abnormal results following the initial installation and operational testing. The purposes of this work were to find the causes of the abnormal results and correct them if possible; check the calibrations and adjust them if necessary; and to provide a better in-depth understanding of what the unit is monitoring and how well it performs under this application. Results have shown that there were some problems associated with the unit as initially installed and tested. These problems have been identified and suggested alternatives shown, the monitor was found to be applicable to some extent under the current conditions. The calibrations have been checked and adjustments made. More operation testing and evaluation is needed to assess how well this works under a variety of ATR operating conditions. 2 references, 10 figures, 3 tables

  16. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 14 + 15 + 16 from track "Energy Flexibility & Storage".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 14 + 15 + 16 from track "Energy Flexibility & Storage"....

  17. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 4 + 5 + 6 + 7 from track "Building Technologies".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 4 + 5 + 6 + 7 from track "Building Technologies"....

  18. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 34 + 35 +36 from track "Commissioning, Control & Energy Mangement".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 34 + 35 +36 from track "Commissioning, Control & Energy Mangement"....

  19. IEEE Nuclear Science Symposium and Medical Imaging Conference

    CERN Document Server

    2016-01-01

    The NSS/MIC is a well-established meeting that has continuously provided an exceptional venue to showcase outstanding developments and contributions across the nuclear and medical instrumentation fields. This conference brings together engineers and scientists from around the world to share their knowledge and to gain insight and inspiration from others. The conference will include a distinguished series of short courses, relevant refresher courses, and workshops that will address areas of particular interest.

  20. ATR-IR study of skin components: Lipids, proteins and water. Part I: Temperature effect

    Science.gov (United States)

    Olsztyńska-Janus, S.; Pietruszka, A.; Kiełbowicz, Z.; Czarnecki, M. A.

    2018-01-01

    In this work we report the studies of the effect of temperature on skin components, such as lipids, proteins and water. Modifications of lipids structure induced by increasing temperature (from 20 to 90 °C) have been studied using ATR-IR (Attenuated Total Reflectance Infrared) spectroscopy, which is a powerful tool for characterization of the molecular structure and properties of tissues, such as skin. Due to the small depth of penetration (0.6-5.6 μm), ATR-IR spectroscopy probes only the outermost layer of the skin, i.e. the stratum corneum (SC). The assignment of main spectral features of skin components allows for the determination of phase transitions from the temperature dependencies of band intensities [e.g. νas(CH2) and νs(CH2)]. The phase transitions were determined by using two methods: the first one was based on the first derivative of the Boltzmann function and the second one employed tangent lines of sigmoidal, aforementioned dependencies. The phase transitions in lipids were correlated with modifications of the structure of water and proteins.

  1. One-day live webcast of the TEDGlobal 2012 Conference

    CERN Multimedia

    2012-01-01

    We would like to invite you to a one-day live webcast of the TEDGlobal 2012 Conference. TED is a nonprofit organisation devoted to Ideas Worth Spreading. It started out (in 1984) as a conference bringing together people from three worlds: Technology, Entertainment, Design. The two annual TED conferences, in Long Beach/Palm Springs and Edinburgh, Scotland, bring together the world's most fascinating thinkers and doers, who are challenged to give the talk of their lives (in 18 minutes or less).   TED includes the TEDx programs which give communities, organisations and individuals the opportunity to stimulate dialogue through TED-like experiences at the local level. TEDx events are planned and coordinated independently. CERN is investigating the possibility of holding a TEDx event in the future. Follow @TEDxCERN on twitter or like our TEDxCERN Facebook page for more information as it becomes available. Meanwhile, on 27 June, we will be showing 3 sessions of the TEDGlobal 2012 live...

  2. Measured thermal and fast neutron fluence rates for ATF-1 holders during ATR cycle 160A

    International Nuclear Information System (INIS)

    Walker, B. J.; Miller, D. T.

    2017-01-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 160A which were measured by the Radiation Measurements Laboratory (RML).

  3. Measured thermal and fast neutron fluence rates for ATF-1 holders during ATR cycle 160A

    Energy Technology Data Exchange (ETDEWEB)

    Walker, B. J. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, D. T. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-06-06

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 160A which were measured by the Radiation Measurements Laboratory (RML).

  4. Sobre el iuspositivismo que hemos de dejar atrás. Una crítica iusnaturalista a "Dejemos atrás el positivismo jurídico" de Atienza y de Ruiz Manero

    Directory of Open Access Journals (Sweden)

    JOSÉ CHÁVEZ-FERNÁNDEZ

    2011-01-01

    Full Text Available A través de la confrontación de las tesis más relevantes que Atienza y Ruiz Manero proponen en su artículo "Dejemos atrás el positivismo jurídico", el autor pretende mostrar-a partir de la respuesta a las preguntas "¿qué iuspositivismo hemos de dejar atrás?", "¿por qué?" y "¿cómo?"- que existen en el iuspositivismo debilidades explicativas graves respecto de la realidad jurídica, y que estas están vinculadas tanto al escepticismo ético como a la negación de la existencia de un Derecho natural en sentido propio, es decir, de raigambre antropológico-metafísica. Por otro lado, se tratará de evidenciar que dichas debilidades explicativas le son comunes también a los intentos pragmático-constructivistas de superación del iuspositivismo por lo que, en última instancia, ninguno de dichos esquemas conceptuales puede dar cuenta cabal de una realidad como los derechos humanos que se presentan como deudas ético-jurídicas inexcusables fundamentadas en la dignidad ontológica de todos los seres humanos.

  5. Diamond-coated ATR prism for infrared absorption spectroscopy of surface-modified diamond nanoparticles

    Czech Academy of Sciences Publication Activity Database

    Remeš, Zdeněk; Kozak, Halyna; Rezek, Bohuslav; Ukraintsev, Egor; Babchenko, Oleg; Kromka, Alexander; Girard, H.A.; Arnault, J.-C.; Bergonzo, P.

    2013-01-01

    Roč. 270, APR (2013), s. 411-417 ISSN 0169-4332 R&D Projects: GA ČR GAP108/12/0910; GA ČR GPP205/12/P331; GA MŠk LH12236; GA MŠk LH12186 Institutional support: RVO:68378271 Keywords : ATR FTIR * CVD * hydrogenation * microwave * nanocrystalline diamond * nanopowder Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.538, year: 2013

  6. Marketing in the E-Business World, Parts I & II | Smith | LBS ...

    African Journals Online (AJOL)

    Marketing in the E-Business World, Parts I & II. ... Open Access DOWNLOAD FULL TEXT ... of many of Americas largest companies gather at the Waldorf Astoria Hotel in New York City for the Conference Boards Annual Marketing Conference.

  7. Preliminary Assessment of ATR-C Capabilities to Provide Integral Benchmark Data for Key Structural/Matrix Materials that May be Used for Nuclear Data Testing and Analytical Methods Validation

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess

    2009-07-01

    The purpose of this document is to identify some suggested types of experiments that can be performed in the Advanced Test Reactor Critical (ATR-C) facility. A fundamental computational investigation is provided to demonstrate possible integration of experimental activities in the ATR-C with the development of benchmark experiments. Criticality benchmarks performed in the ATR-C could provide integral data for key matrix and structural materials used in nuclear systems. Results would then be utilized in the improvement of nuclear data libraries and as a means for analytical methods validation. It is proposed that experiments consisting of well-characterized quantities of materials be placed in the Northwest flux trap position of the ATR-C. The reactivity worth of the material could be determined and computationally analyzed through comprehensive benchmark activities including uncertainty analyses. Experiments were modeled in the available benchmark model of the ATR using MCNP5 with the ENDF/B-VII.0 cross section library. A single bar (9.5 cm long, 0.5 cm wide, and 121.92 cm high) of each material could provide sufficient reactivity difference in the core geometry for computational modeling and analysis. However, to provide increased opportunity for the validation of computational models, additional bars of material placed in the flux trap would increase the effective reactivity up to a limit of 1$ insertion. For simplicity in assembly manufacture, approximately four bars of material could provide a means for additional experimental benchmark configurations, except in the case of strong neutron absorbers and many materials providing positive reactivity. Future tasks include the cost analysis and development of the experimental assemblies, including means for the characterization of the neutron flux and spectral indices. Oscillation techniques may also serve to provide additional means for experimentation and validation of computational methods and acquisition of

  8. Application of FTIR-ATR Spectroscopy for the quality control of wine spirits, brandies and grape marc spirits

    OpenAIRE

    Anjos, O.; Caldeira, I.

    2013-01-01

    This study attempted to apply a rapid method for the determination of methanol, acetaldehyde and ethyl acetate in wine spirits, brandies and grape marc spirits, using Fourier Transform Infrared – Attenuated Total Reflectance (ATR) Spectroscopy.

  9. ENS Conference, jointly organised together with FORATOM

    International Nuclear Information System (INIS)

    2013-01-01

    This abstract contains the programme of the 2013 conference on Public Information Materials Exchange, PIME, which is the annual focal point for professional nuclear communicators all around the world. The conference is designed especially for communicators in the nuclear industry and research communities. The PIME programme revolves around a series of plenary sessions and interactive workshops. This programme document lists the contributions made to the 25"t"h anniversary PIME held in Zürich in February 2013 with four plenary sessions and six workshops

  10. Bursting onto the big stage: Presenting at an international conference for the first time

    OpenAIRE

    Manley, AJ; Meijen, C

    2008-01-01

    Attending a prestigious international conference and contributing to proceedings by delivering a poster or oral presentation is an excellent opportunity for sport and exercise psychology students to gain valuable experience and meet people from different parts of the world. In this article, we will focus on presenting at an international conference for the first time. An international conference presents different challenges compared to annual national and regional conferences. It will often ...

  11. Prioritizing environmental issues around the world: opinions from an international Central and Eastern European environmental health conference.

    Science.gov (United States)

    Craft, Elena S; Donnelly, Kirby C; Neamtiu, Iulia; McCarty, Kathleen M; Bruce, Erica; Surkova, Irina; Kim, David; Uhnakova, Iveta; Gyorffy, Erika; Tesarova, Eva; Anderson, Beth

    2006-12-01

    As the next generation of scientists enters the field of environmental health, it is imperative that they view their contributions in the context of global environmental stewardship. In this commentary, a group of international graduate students facilitated by three experienced environmental health scientists present their views on what they consider to be the global environmental health concerns of today. This group convened initially in October 2004 at an international health conference in Prague, Czech Republic. In this report we identify perceived environmental health concerns that exist around the world, with a focus on Central and Eastern Europe. Additionally, we address these perceived problems and offers some potential solutions. At the meeting, students were invited to participate in two panel discussions. One group of young international scientists identified several significant global environmental health concerns, including air pollution, occupational hazards, and risk factors that may exacerbate current environmental health issues. The second panel determined that communication, education, and regulation were the mechanisms for addressing current environmental challenges. In this commentary we expand on the views presented at the meeting and represent the concerns of young investigators from nine different countries. We provide ideas about and support the exchange of information between developed and developing countries on how to handle the environmental health challenges that face the world today.

  12. 3rd International Conference on Dynamics, Games and Science & 7th Berkeley Bioeconomy Conference

    CERN Document Server

    Zilberman, David

    2017-01-01

    The concepts and techniques presented in this volume originated from the fields of dynamics, statistics, control theory, computer science and informatics, and are applied to novel and innovative real-world applications. Over the past few decades, the use of dynamic systems, control theory, computing, data mining, machine learning and simulation has gained the attention of numerous researchers from all over the world. Admirable scientific projects using both model-free and model-based methods coevolved at today’s research centers and are introduced in conferences around the world, yielding new scientific advances and helping to solve important real-world problems. One important area of progress is the bioeconomy, where advances in the life sciences are used to produce new products in a sustainable and clean manner. In this book, scientists from all over the world share their latest insights and important findings in the field.  The majority of the contributed papers for this volume were written by particip...

  13. Conferinţa Mondială a Populaţiei, Bucureşti 1974. Semnificaţii politice (World Population Conference, Bucharest 1974. Political Meanings

    Directory of Open Access Journals (Sweden)

    Cezar STANCIU

    2014-09-01

    Full Text Available n 1974, the United Nations organized the first inter-governmental conference dedicated especially to problems of population and demography. Apart from technical issue involved, the conference represented yet another manifestation of disagreements between the industrialized countries, on one hand, and the underdeveloped or developing countries. The first group argued that overpopulation was a major risk as the Earth did not have sufficient resources to feed the ever-growing population and birth control measures were required. The latter group disagreed with this perspective and claimed that population issues could be solved only by the development of the poor countries. Development, argued this group of countries, had to be insured by a restructuring of the international economy and more financial assistance from the developed countries. This paper examines Romania’s position in this context, analyzing how the regime in Bucharest tried to balance between foreign constraints such as its obligation as host country to remain neutral, its effort to build bridges to the underdeveloped or developing countries thus trying to tacitly evade it international status of Warsaw Pact member and gain acceptance in the Group of 77. The World Population Conference in 1974 is a conclusive case study for Romania’s foreign policy after the Soviet-American détente of 1972.

  14. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 24 + 25 +26 + 27 + 28 +29 + 30 from track "Building Performance".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 24 + 25 +26 + 27 + 28 +29 + 30 from track "Building Performance"....

  15. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 8 + 9 + 10 + 11 + 12 + 13 from track "Sustainable Energy"....

  16. World Sustainable Energy Days Next 2014

    CERN Document Server

    Egger, Christiane

    2015-01-01

    These conference proceedings contain contributions to one of Europe’s largest annual conferences on energy efficiency and renewable energy. From two main fields – biomass and energy efficiency in buildings – contributions offer an insight into the research work and the scientific findings and developments of young researchers from all over the world. The papers were selected by a high-level scientific committee for oral presentation. They also communicate results, trends and opinions that will concern and influence the world’s energy experts and policy makers over the next decades. The conference was held from 26-27 February 2014. The conference The conference is organized by the Energy Agency of Upper Austria (OÖ Energiesparverband) and held in Wels annually in February or March. It attracts more than 700 experts from over 50 countries every year. The Editors Christiane Egger is the deputy managing director of the OÖ Energiesparverband and the Manager of the Ökoenergie-Cluster, a network of 160 co...

  17. Conference Attendees’ Satisfaction: Evidence from Belgrade (Serbia

    Directory of Open Access Journals (Sweden)

    Dunjić Jelena

    2012-10-01

    Full Text Available Conference industry brings significant economic effects and that is one of the reasons why many destinations around the world strive to organize conferences, especially the international ones, which make bigger economic effects. According to the Strategy of tourism development of the Republic of Serbia (2005-2015, city break and business tourism are tourism products of high priority, which can provide short-term positioning of Novi Sad and Belgrade, at the first place, at the international tourism market, and contribute to the growth of tourism turnover of foreign travellers.Belgrade is the capital and the largest city in Serbia. It is very well equipped with necessary infrastructure for organizing business events such as conferences, congresses, meetings etc. Lately, the number of international business events in Serbia is increasing and the majority of those events are organized in Belgrade. However, there are very few surveys which are examining satisfaction of the conference attendees in Serbia. This topic is often ignored despite the fact that the attendees satisfaction is substantial for organizers and all other relevant stakeholders at host destination. Therefore, the aim of this paper is to analyze the satisfaction of the conference attendees, as they are final consumers of conference tourist product and their experience regarding both conference and host destination is thus essential to destination marketing and management organizations, conference centres, hotel managers, meeting planners and all other stakeholders involved in conference industry and tourism

  18. Radar automatic target recognition (ATR) and non-cooperative target recognition (NCTR)

    CERN Document Server

    Blacknell, David

    2013-01-01

    The ability to detect and locate targets by day or night, over wide areas, regardless of weather conditions has long made radar a key sensor in many military and civil applications. However, the ability to automatically and reliably distinguish different targets represents a difficult challenge. Radar Automatic Target Recognition (ATR) and Non-Cooperative Target Recognition (NCTR) captures material presented in the NATO SET-172 lecture series to provide an overview of the state-of-the-art and continuing challenges of radar target recognition. Topics covered include the problem as applied to th

  19. Fifth International Conference KSE 2013

    CERN Document Server

    Denoeux, Thierry; Tran, Dang; Le, Anh; Pham, Son; Knowledge and Systems Engineering

    2014-01-01

    The field of Knowledge and Systems Engineering (KSE) has experienced rapid development and inspired many applications in the world of information technology during the last decade. The KSE conference aims at providing an open international forum for presentation, discussion and exchange of the latest advances and challenges in research of the field. These proceedings contain papers presented at the Fifth International Conference on Knowledge and Systems Engineering (KSE 2013), which was held in Hanoi, Vietnam, during 17–19 October, 2013. Besides the main track of contributed papers, which are compiled into the first volume, the conference also featured several special sessions focusing on specific topics of interest as well as included one workshop, of which the papers form the second volume of these proceedings. The book gathers a total of 68 papers describing recent advances and development on various topics including knowledge discovery and data mining, natural language processing, expert systems, intell...

  20. 5th European Rheology Conference

    CERN Document Server

    1998-01-01

    Global sustainable development of the world economy requires better understanding and utilization of natural recourses. In this endeavor rheology has an indispensable role. The Rheology Conferences are therefore always an important event for science and technology. The Fifth European Rheology Conference, held from September 6 to 11 in the Portoro-z, Slovenia, will be the first AlI-European rheology meeting after the formal constitution of the European Society ofRheology. As such it will be a special historical event. At this meeting the European Society of Rheology will introduce the Weissenberg Medal, to be bestowed every four years to an individual for hislhers contribution to the field of Rheology. The recipient ofthe first award will be professor G. Marrucci ofthe Universita degli Studi di Napoli, Italy. Two mini Symposia will be part of the Conference. The first, on Industrial Rheology, will commemorate the late professor G. Astarita. The second will honor the eightieth birthday of professor N.W. Tschoeg...

  1. Fourth International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems IV

    2008-01-01

    In June of 2002, over 500 professors, students and researchers met in Boston, Massachusetts for the Fourth International Conference on Complex Systems. The attendees represented a remarkably diverse collection of fields: biology, ecology, physics, engineering, computer science, economics, psychology and sociology, The goal of the conference was to encourage cross-fertilization between the many disciplines represented and to deepen understanding of the properties common to all complex systems. This volume contains 43 papers selected from the more than 200 presented at the conference. Topics include: cellular automata, neurology, evolution, computer science, network dynamics, and urban planning. About NECSI: For over 10 years, The New England Complex Systems Institute (NECSI) has been instrumental in the development of complex systems science and its applications. NECSI conducts research, education, knowledge dissemination, and community development around the world for the promotion of the study of complex sys...

  2. Third International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems

    2006-01-01

    In recent years, scientists have applied the principles of complex systems science to increasingly diverse fields. The results have been nothing short of remarkable: their novel approaches have provided answers to long-standing questions in biology, ecology, physics, engineering, computer science, economics, psychology and sociology. The Third International Conference on Complex Systems attracted over 400 researchers from around the world. The conference aimed to encourage cross-fertilization between the many disciplines represented and to deepen our understanding of the properties common to all complex systems. This volume contains selected transcripts from presentations given at the conference. Speakers include: Chris Adami, Kenneth Arrow, Michel Baranger, Dan Braha, Timothy Buchman, Michael Caramanis, Kathleen Carley, Greg Chaitin, David Clark, Jack Cohen, Jim Collins, George Cowan, Clay Easterly, Steven Eppinger, Irving Epstein, Dan Frey, Ary Goldberger, Helen Harte, Leroy Hood, Don Ingber, Atlee Jackson,...

  3. Third International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems

    2006-01-01

    In recent years, scientists have applied the principles of complex systems science to increasingly diverse fields. The results have been nothing short of remarkable: their novel approaches have provided answers to long-standing questions in biology, ecology, physics, engineering, computer science, economics, psychology and sociology. The Third International Conference on Complex Systems attracted over 400 researchers from around the world. The conference aimed to encourage cross-fertilization between the many disciplines represented and to deepen our understanding of the properties common to all complex systems. This volume contains over 35 papers selected from those presented at the conference on topics including: self-organization in biology, ecological systems, language, economic modeling, ecological systems, artificial life, robotics, and complexity and art. ALI MINAI is an Affiliate of the New England Complex Systems Institute and an Associate Professor in the Department of Electrical and Computer Engine...

  4. Preliminary Assessment of ATR-C Capabilities to Provide Integral Benchmark Data for Key Structural/Matrix Materials that May be Used for Nuclear Data Testing and Analytical Methods Validation

    Energy Technology Data Exchange (ETDEWEB)

    John D. Bess

    2009-03-01

    The purpose of this research is to provide a fundamental computational investigation into the possible integration of experimental activities with the Advanced Test Reactor Critical (ATR-C) facility with the development of benchmark experiments. Criticality benchmarks performed in the ATR-C could provide integral data for key matrix and structural materials used in nuclear systems. Results would then be utilized in the improvement of nuclear data libraries and as a means for analytical methods validation. It is proposed that experiments consisting of well-characterized quantities of materials be placed in the Northwest flux trap position of the ATR-C. The reactivity worth of the material could be determined and computationally analyzed through comprehensive benchmark activities including uncertainty analyses. Experiments were modeled in the available benchmark model of the ATR using MCNP5 with the ENDF/B-VII.0 cross section library. A single bar (9.5 cm long, 0.5 cm wide, and 121.92 cm high) of each material could provide sufficient reactivity difference in the core geometry for computational modeling and analysis. However, to provide increased opportunity for the validation of computational models, additional bars of material placed in the flux trap would increase the effective reactivity up to a limit of 1$ insertion. For simplicity in assembly manufacture, approximately four bars of material could provide a means for additional experimental benchmark configurations, except in the case of strong neutron absorbers and many materials providing positive reactivity. Future tasks include the cost analysis and development of the experimental assemblies, including means for the characterization of the neutron flux and spectral indices. Oscillation techniques may also serve to provide additional means for experimentation and validation of computational methods and acquisition of integral data for improving neutron cross sections. Further assessment of oscillation

  5. CLIMA 2016 - proceedings of the 12th REHVA World Congress

    DEFF Research Database (Denmark)

    CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 17 + 18 + 19 + 20 +21 + 22 + 23 from track "Ventilation & Air Distribution".......CLIMA 2016, 12th REHVA World Congress 2016 in Aalborg north of Denmark. Full reviewed papers presented at CLIMA 2016 is published in the conference proceedings. This volume contains the sessions number 17 + 18 + 19 + 20 +21 + 22 + 23 from track "Ventilation & Air Distribution"....

  6. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

    DEFF Research Database (Denmark)

    Lopez-Contreras, Andres J; Specks, Julia; Barlow, Jacqueline H

    2015-01-01

    In Saccharomyces cerevisiae, absence of the checkpoint kinase Mec1 (ATR) is viable upon mutations that increase the activity of the ribonucleotide reductase (RNR) complex. Whether this pathway is conserved in mammals remains unknown. Here we show that cells from mice carrying extra alleles of the...

  7. Analytical characterization of polymers used in conservation and restoration by ATR-FTIR spectroscopy.

    Science.gov (United States)

    Chércoles Asensio, Ruth; San Andrés Moya, Margarita; de la Roja, José Manuel; Gómez, Marisa

    2009-12-01

    In the last few decades many new polymers have been synthesized that are now being used in cultural heritage conservation. The physical and chemical properties and the long-term behaviors of these new polymers are determined by the chemical composition of the starting materials used in their synthesis along with the nature of the substances added to facilitate their production. The practical applications of these polymers depend on their composition and form (foam, film, sheets, pressure-sensitive adhesives, heat-seal adhesives, etc.). Some materials are used in restoration works and others for the exhibition, storage and transport of works of art. In all cases, it is absolutely necessary to know their compositions. Furthermore, many different materials that are manufactured for other objectives are also used for conservation and restoration. The technical information about the materials provided by the manufacturer is usually incomplete, so it is necessary to analytically characterize such materials. FTIR spectrometry is widely used for polymer identification, and, more recently, ATR-FTIR has been shown to give excellent results. This paper reports the ATR-FTIR analysis of samples of polymeric materials used in the conservation of artworks. These samples were examined directly in the solid material without sample preparation.

  8. Proceedings of the CERI 2006 oil conference : tight as a drum

    International Nuclear Information System (INIS)

    2006-01-01

    Since 2004, the tight world oil market throughout the entire supply chain has been reflected in high and volatile prices for premium crude, wide crude quality differentials, and high refining margins. This oil conference was attended by international energy experts who addressed these, and other important issues affecting market developments. In addition to issues affecting world oil prices in the short-term as well as long-term world oil demand, the presentations addressed oil supply potential and oil price differentials. Geopolitical hotspots affecting the market were also discussed along with markets for Canadian oil and factors that could impede Alberta's oil sands development, including transportation options for oil sands operators. The conference featured 23 presentations, of which 2 have been catalogued separately for inclusion in this database. refs., tabs., figs

  9. Prediction of the oversulphated chondroitin sulphate contamination of unfractionated heparin by ATR-IR spectrophotometry.

    Science.gov (United States)

    Norwig, J; Beyer, T; Brinz, D; Holzgrabe, U; Diller, M; Manns, D

    2009-03-01

    The detection of a contamination of heparin with oversulphated chondroitin sulphate (OSCS) was first analysed in an unfractionated heparin batch supplied to the US API-market in April 2006. OSCS is a semi-synthetic derivative of the natural occuring glycosaminoglycan chondroitin sulphate. Moreover some spectroscopic characteristics of the substance overlap with those of heparin, so that the infrared (IR) spectra are visually difficult to distinguish whereas (1)H-NMR (Nuclear Magnetic Resonance) spectroscopy or capillary electrophoresis (CE) provides identification by a simple visual inspection of either the spectrum or the electropherogram respectively. However, applying special tools of Multivariate Data Analysis (MVA) to the IR spectra an identification of the contaminated samples is possible. In detail a rapid Attenuation Total Reflectance-Infrared (ATR-IR) measurement was selected, which does not require any sample preparation. The result (contaminated or not contaminated) is predicted within a few minutes. A method transfer to mobile ATR-IR spectrometers seems to be possible. The analysis is based on the fact that the fingerprint of the OSCS IR spectrum (1st derivative) complies with a theoretically calculated principal component in the MVA.

  10. Characterization of Printing Inks Using DART-Q-TOF-MS and Attenuated Total Reflectance (ATR) FTIR.

    Science.gov (United States)

    Williamson, Rhett; Raeva, Anna; Almirall, Jose R

    2016-05-01

    The rise in improved and widely accessible printing technology has resulted in an interest to develop rapid and minimally destructive chemical analytical techniques that can characterize printing inks for forensic document analysis. Chemical characterization of printing inks allows for both discrimination of inks originating from different sources and the association of inks originating from the same source. Direct analysis in real-time mass spectrometry (DART-MS) and attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) were used in tandem to analyze four different classes of printing inks: inkjets, toners, offset, and intaglio. A total of 319 samples or ~ 80 samples from each class were analyzed directly on a paper substrate using the two methods. DART-MS was found to characterize the semi-volatile polymeric vehicle components, while ATR-FTIR provided chemical information associated with the bulk components of these inks. Complimentary data results in improved discrimination when both techniques are used in succession resulting in >96% discrimination for all toners, 95% for all inkjets, >92% for all offset, and >54% for all intaglio inks. © 2016 American Academy of Forensic Sciences.

  11. WorldWideScience.org: Bringing Light to Grey

    OpenAIRE

    Hitson, Brian A. (OSTI-DOE); Johnson, Lorrie A. (OSTI-DOE); GreyNet, Grey Literature Network Service

    2008-01-01

    WorldWideScience.org and its governance structure, the WorldWideScience Alliance, are putting a brighter spotlight on grey literature. Through this new tool, grey literature is getting broader exposure to audiences all over the world. Improved access to and sharing of research information is the key to accelerating progress and breakthroughs in any field, especially science. Includes: Conference preprint, Powerpoint presentation, Abstract and Biographical notes, Pratt student commentary ...

  12. PREFACE: The Irago Conference 2012

    Science.gov (United States)

    Sandhu, Adarsh; Okada, Hiroshi

    2013-04-01

    The Irago Conference 2012 - 360 degree outlook on critical scientific and technological challenges for a sustainable society Organized by the Electronics-Inspired Interdisciplinary Research Institute (EIIRIS) at Toyohashi University of Technology, the Irago Conference, held recently (15-16 November) in Aichi, Japan, aimed to enhance mutual understanding between scientists, engineers and policymakers. Over 180 participants tackled topics ranging from energy and natural resources to public health and disaster prevention. The 360-degree outlook of the conference impressed speakers and guests. ''This conference has been extremely informative,'' noted Robert Gellar from the University of Tokyo. ''A unique conference with experts from a range of backgrounds,'' agreed Uracha Ruktanonchai from the National Nanotechnology Center (NANOTEC) in Thailand. Similarly, G P Li, professor of electrical engineering and computer science at the University of California Irvine commented that he had been ''able to think the unthinkable'' as a range of topics came together. The conference was streamed live on Ustream to ensure that researchers from across the world could benefit from thought-provoking presentations examining global issues such as energy, disaster mitigation and nanotechnology. ''This was wonderful,'' said Oussama Khatib from Stanford University, ''A good recipe of speakers from such a range of backgrounds.'' Manuscripts submitted to the organizers were peer-reviewed, and the papers in this proceedings were accepted for Journal of Physics: Conference Series. In addition to the formal speaker programme, graduate-student sessions provided a platform for graduate students to describe their latest findings as oral presentations. A series of excursions to relevant locations, such as the Tahara megasolar region under construction and a local car-manufacturing factory, gave participants the opportunity to further consider practical applications of their research in industry

  13. Security of supply in Competitive Electricity Markets. Conference proceedings

    International Nuclear Information System (INIS)

    2005-06-01

    A stable and reliable electricity supply is a fundamental factor in our modern economy and many people think that the deregulated market is a threat to this - or at least, they think that there is a need for a new type of regulation. Others believe that the threat to security of supply comes from short sighted politicians rather than from competitive markets. Regulation in order to increase security of supply is a threat to well functioning competitive markets - not the other way around. To give an overview of different regulatory models and to discuss each model's particular pros and cons, ELFORSK (Swedish Electrical Utilities RandD Company) on behalf of the Swedish electricity industry, the national grid company Svenska Kraftnaet and the Regulating Authority has arranged this two-day Conference. This conference once again gathers people from many different parts of the world to exchange ideas and experiences from their respective area of operations. Our belief is that people from the industry, the governments as well as from the academic world will find these two days a useful opportunity to build new relationships and gain new insights into the topics covered. There are three main topics for the Conference: Experiences from Different Markets; The Value of Security of Supply; Ongoing research projects. The members of the Conference Committee are impressed by the quality of the papers presented at this Conference and we believe that this is a source of knowledge that will influence decisions makers in many countries. (11 papers presented at the conference have been indexed separately. Powerpoint presentations have not been indexed but are available from the Market Design homrpage)

  14. The joint accelerator conferences website, JACoW. An open access website for the publication of conference proceedings in accelerator science and technology

    International Nuclear Information System (INIS)

    Christine, Petit-Jean-Genaz

    2015-01-01

    The Joint Accelerator Conferences Website (JACoW), at http://www.JACoW.org came into being in the mid-nineties with the publication of the first electronic set of European Particle Accelerator Conference (EPAC) proceedings on the World Wide Web, on a server located at CERN. The publication of that first set of conference proceedings 18 years ago had developed into an international collaboration in electronic publication of accelerator science and technology conference proceedings, with at the time of writing, 18 collaborating conference series and 167 sets of proceedings published. The story of how this came about, the lessons learned along the way, are described by the author who has been part of this exciting adventure from the earliest days. This article will avoid detail of the technicalities of electronic publication, which are fully documented at the site mentioned above. It will simply tell the tale of JACoW, the people involved and their adventures. (author)

  15. Assessment of the second conference

    Energy Technology Data Exchange (ETDEWEB)

    Eklund, S A [International Atomic Energy Agency, Vienna (Austria)

    1964-08-15

    Full text: (Sigvard A. Eklund, Conference Secretary General of the Second Conference, 1958). The Geneva Conference of 1958 was up to then the world's biggest and most comprehensive conference concerned with science and technology. Its description - the peaceful uses of atomic energy - was somewhat deceptive, since the conference covered not only engineering applications and energy problems but the nuclear sciences as a whole. It promoted specialized information, but at the same time attempted to counteract the tendency for overspecialization by attracting scientists and technicians from all the various disciplines which have contributed to the development of atomic energy. Such a big international meeting held under the auspices of the United Nations was effective in a manner different to that of smaller meetings in that it stimulated Governments to release and review material which otherwise might have remained undigested or buried in sometimes inaccessible reports and documents. The timing of the conference was propitious. The advanced countries had successfully operated research reactors long enough to enable the less advanced nations to be provided with much needed information; radioisotopes had become available on a relatively large scale and at lower prices. Consequently research, which had previously been restricted to a small number of privileged institutions, could be carried out anywhere; industry could freely benefit from the same tools; and - perhaps most important from the human aspect - methods could be introduced in medicine which offered new possibilities. In theoretical physics a whole series of newly discovered particles with intriguing properties stimulated the imagination of physicists. After an experimental and testing period the first power reactors were going into operation. Data and experience on fuel and on constructional problems had become available which justified a technical evaluation of the situation. Following the 1955 conference

  16. Assessment of the second conference

    International Nuclear Information System (INIS)

    Eklund, S.A.

    1964-01-01

    Full text: (Sigvard A. Eklund, Conference Secretary General of the Second Conference, 1958). The Geneva Conference of 1958 was up to then the world's biggest and most comprehensive conference concerned with science and technology. Its description - the peaceful uses of atomic energy - was somewhat deceptive, since the conference covered not only engineering applications and energy problems but the nuclear sciences as a whole. It promoted specialized information, but at the same time attempted to counteract the tendency for overspecialization by attracting scientists and technicians from all the various disciplines which have contributed to the development of atomic energy. Such a big international meeting held under the auspices of the United Nations was effective in a manner different to that of smaller meetings in that it stimulated Governments to release and review material which otherwise might have remained undigested or buried in sometimes inaccessible reports and documents. The timing of the conference was propitious. The advanced countries had successfully operated research reactors long enough to enable the less advanced nations to be provided with much needed information; radioisotopes had become available on a relatively large scale and at lower prices. Consequently research, which had previously been restricted to a small number of privileged institutions, could be carried out anywhere; industry could freely benefit from the same tools; and - perhaps most important from the human aspect - methods could be introduced in medicine which offered new possibilities. In theoretical physics a whole series of newly discovered particles with intriguing properties stimulated the imagination of physicists. After an experimental and testing period the first power reactors were going into operation. Data and experience on fuel and on constructional problems had become available which justified a technical evaluation of the situation. Following the 1955 conference

  17. Determination of alkaloids in capsules, milk and ethanolic extracts of poppy (Papaver somniferum L.) by ATR-FT-IR and FT-Raman spectroscopy.

    Science.gov (United States)

    Schulz, Hartwig; Baranska, Malgorzata; Quilitzsch, Rolf; Schütze, Wolfgang

    2004-10-01

    Fourier transform (FT) infrared spectroscopy using a diamond composite ATR crystal and NIR-FT-Raman spectroscopy techniques were applied for the simultaneous identification and quantification of the most important alkaloids in poppy capsules. Most of the characteristic Raman signals of the alkaloids can be identified in poppy milk isolated from unripe capsules. But also poppy extracts present specific bands relating clearly to the alkaloid fraction. Raman spectra obtained by excitation with a Nd:YAG laser at 1064 nm show no disturbing fluorescence effects; therefore the plant tissue can be recorded without any special preparation. The used diamond ATR technique allows to measure very small sample amounts (5-10 microL or 2-5 mg) without the necessity to perform time-consuming pre-treatments. When applying cluster analysis a reliable discrimination of "low-alkaloid" and "high-alkaloid" poppy single-plants can be easily achieved. The examples presented in this study provide clear evidence of the benefits of Raman and ATR-IR spectroscopy in efficient quality control, forensic analysis and high-throughput evaluation of poppy breeding material.

  18. Managing nuclear weapons in a changing world: Proceedings

    International Nuclear Information System (INIS)

    1992-01-01

    The Center for Security and Technology Studies was established at the Lawrence Livermore National Laboratory to support long-range technical studies on issues of importance to US national security. An important goal of the Center is to bring together Laboratory staff and the broader outside community through a program of technical studies, visitors, symposia, seminars, workshops, and publications. With this in mind, the Center and LLNL's Defense Systems Program sponsored a conference on Managing Nuclear Weapons in a Changing World held on November 17--18,1992. The first day of the meeting focused on nuclear weapons issues in the major geographical areas of the world. On the second day, the conference participants discussed what could be done to manage, control, and account for nuclear weapons in this changing world. Each of the talks and the concluding panel discussion are being indexed as separate documents

  19. Managing nuclear weapons in a changing world: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1992-12-31

    The Center for Security and Technology Studies was established at the Lawrence Livermore National Laboratory to support long-range technical studies on issues of importance to US national security. An important goal of the Center is to bring together Laboratory staff and the broader outside community through a program of technical studies, visitors, symposia, seminars, workshops, and publications. With this in mind, the Center and LLNL`s Defense Systems Program sponsored a conference on Managing Nuclear Weapons in a Changing World held on November 17--18,1992. The first day of the meeting focused on nuclear weapons issues in the major geographical areas of the world. On the second day, the conference participants discussed what could be done to manage, control, and account for nuclear weapons in this changing world. Each of the talks and the concluding panel discussion are being indexed as separate documents.

  20. Electrooxidation of ethanol on Pt and PtRu surfaces investigated by ATR surface-enhanced infrared absorption spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Marcio F.; Camara, Giuseppe A., E-mail: giuseppe.silva@ufms.br [Departamento de Quimica, Universidade Federal do Mato Grosso do Sul, Campo Grande-MS (Brazil); Batista, Bruno C.; Boscheto, Emerson [Instituto de Quimica de Sao Carlos, Universidade de Sao Paulo, Sao Carlos-SP, (Brazil); Varela, Hamilton, E-mail: varela@iqsc.usp.br [Ertl Center for Electrochemistry and Catalysis, Gwangju Institute of Science and Technology (GIST), Gwangju (Korea, Republic of)

    2012-05-15

    Herein, it was investigated for the first time the electro-oxidation of ethanol on Pt and PtRu electrodeposits in acidic media by using in situ surface enhanced infrared absorption spectroscopy with attenuated total reflection (ATR-SEIRAS). The experimental setup circumvents the weak absorbance signals related to adsorbed species, usually observed for rough, electrodeposited surfaces, and allows a full description of the CO coverage with the potential for both catalysts. The dynamics of adsorption-oxidation of CO was accessed by ATR-SEIRAS experiments (involving four ethanol concentrations) and correlated with expressions derived from a simple kinetic model. Kinetic analysis suggests that the growing of the CO adsorbed layer is nor influenced by the presence of Ru neither by the concentration of ethanol. The results suggest that the C-C scission is not related to the presence of Ru and probably happens at Pt sites. (author)

  1. World's fastest supercomputer opens up to users

    Science.gov (United States)

    Xin, Ling

    2016-08-01

    China's latest supercomputer - Sunway TaihuLight - has claimed the crown as the world's fastest computer according to the latest TOP500 list, released at the International Supercomputer Conference in Frankfurt in late June.

  2. The 26th International Nuclear Physics Conference

    Science.gov (United States)

    It was a pleasure to welcome all delegates and accompanying persons to Adelaide for the 26th International Conference in Nuclear Physics, INPC2016. As the major meeting in our field, it was a wonderful opportunity to catch up with colleagues from around the world, learn about the very latest developments and share ideas. We were grateful for the support of the Commission on Nuclear Physics, C12, of the International Union of Pure and Applied Physics (IUPAP), which chose Adelaide to host this meeting. We were also honoured that the President of IUPAP, Prof. Bruce McKellar was present at the meeting to welcome delegates and participate in the proceedings. We acknowledge the financial support for the conference which was made available by a number of organisations. We were especially grateful to the major sponsors, the Adelaide Convention Bureau, the University of Adelaide, the Australian National University and ANSTO, as well as IUPAP, the ARC Centre of Excellence for Particle Physics at the Terascale (CoEPP) and several of the world's major nuclear physics laboratories, BNL, GSI, JLab and TRIUMF. As a result of these contributions we were able to offer support to attend the conference to more than 50 international students. Not only did we have a superb scientific program but, consistent with IUPAP guidelines, more than 40% of the invited plenary talks were presented by women. In order to reach out to the local community, Cynthia Keppel (from JLab) presented a public lecture on Hadron Beam Therapy on Tuesday evening, September 13th. As presenting a talk is now often a condition for financial support to attend an international conference, there were 11 simultaneous parallel sessions with more than 350 presentations. We are especially grateful to the International Advisory Committee, the Program Committee and the Conveners whose advice and hard work made it possible for all this to come together. I would also like to acknowledge the work of the Local Organising

  3. Book of abstracts. Fifteenth Pacific basin nuclear conference

    International Nuclear Information System (INIS)

    2006-10-01

    The 15 th Pacific Basic Nuclear Conference (PBNC) was held in Sydney, Australia.This conference is the first large international conference in nuclear field held in Australia. The 9 th conference in this series was hosted in Sydney in 1994 by the Australian Nuclear Association in a joint venture with The Institution of Engineers Australia (now known as Engineers Australia). The present conference is the 15 th in the series and is also hosted by the Australian Nuclear Association and Engineers Australia. The 16 th conference will be hosted in Japan in October 2008. Australia has abundant resources of uranium and thorium and is an important supplier of uranium to the world's nuclear power stations under strict safeguards agreements. In this conference an extensive range of papers on all aspects of nuclear power and the nuclear fuel cycle were presented. The theme for 15PBNC is a Pacific Nuclear Future: Nuclear Science and Engineering for a Sustainable Society . Abstracts from over 240 papers and 50 posters have been reviewed and accepted in the eight major topic areas: nuclear power; nuclear technology and development; nuclear fuel cycle; safety and regulation; research reactors and applications; nuclear medicine; non proliferation and safeguards; and public information and education. This conference would further promote the wide exchange and cooperation in nuclear technical application areas among international countries

  4. 13th CERI [Canadian Energy Research Inst.] international oil and gas markets conference

    International Nuclear Information System (INIS)

    1994-01-01

    At an oil and gas industry conference, papers were presented on world oil supply and demand, energy geopolitics, world oil prices, the status of the Chinese oil/gas industry and prospects for exploration and development, Latin American oil/gas markets and development opportunities, the oil and gas industries in non-OPEC Middle East countries (Oman, Yemen, Turkey), oil and gas markets in North America, and financial and regulatory aspects of domestic gas markets in Canada and the USA. Separate abstracts have been prepared for 17 papers from this conference

  5. Characterization and sintering of ATR aluminia from niobium

    International Nuclear Information System (INIS)

    Shibuya, N.H.

    1987-01-01

    The characterization of resultante slag from Aluminothermic Reduction (ATR) process to obtain metallic niobium is presented. The slag was characterized for concentration and phases of aluminia by X-ray diffractometry. The results show that 70% of the slag is constituted by α aluminia. The lixiviation and calcination of the slag increased the α aluminia concentration to 95%, the slag was used for producing samples to be burning in three furnaces: electrical resistance furnace in the air, and two furnaces in the vacuum. The burned samples were characterized by microscopy, ultrasonic analysis, density measurements and X-ray diffractometry. The sintering in the vacuum is possible because the samples burned in vacuum presented major density. The formation of NbO 2 and mullite was observed, by X-ray diffractometry. The data from optical microscopy, density measurements and X-ray diffractometry show high porosity. (M.C.K.) [pt

  6. Measured thermal and fast neutron fluence rates ATR Cycle 99-A, November 23, 1992--January 23, 1993

    International Nuclear Information System (INIS)

    Murray, R.K.; Rogers, J.W.

    1993-03-01

    This report contains the thermal (2200 m/s) and fast (E>me) neutron fluence rate data for ATR Cycle 99-A which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power ReactorPrograms (ATR Experiments) Radiation Measurements Work Order. This report contains fluence rate values corresponding to the particular elevations (relative to the 80 ft. core elevation) where the measurements were taken. The data in this report consists of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, (3) plots of both the thermal and fast neutron fluence rates, and (4) a magnetic record (3.5 inch diskette) containing a listing of only the fast neutron fluence rates, their assigned elevations and proper header identification of all monitor positions contained herein. The fluence rates reported are for the average power levels given in the table of power history and distribution. All ''H'' holder monitor wires for this cycle are 54 inches long. All ''SR'' holder monitor wires for this cycle are 55 inches long. This length allows measurement of the full core region and makes the first count elevation 24.73 inches above core midplane. Due to the safety rod problems in the west lobe, ''BR'' holders were used in the W-1, 2, 3, and 4 positions. All ''BR'' holder monitor wires for this cycle are 56.25 inches long. The distance from the end of the wires to the first count position was 4.25 inches for all wires counted from this cycle

  7. World Gas Conference 1997. Working committee J. World gas prospects, strategies and economics

    International Nuclear Information System (INIS)

    1997-01-01

    This volume of the proceedings contains the report of the International Gas Union's Working Committee J - World gas prospects, strategies and economics - and 7 oral papers dealing with natural gas supply and demand and transmission. (LN)

  8. Assessment of the first conference

    Energy Technology Data Exchange (ETDEWEB)

    Whitmann, W G

    1964-08-15

    Full text: (Professor Whitmann was Secretary-General of the 1955 Conference). The dramatic lifting of the Iron Curtain, which had for decades sealed off communication between East and West, was the outstanding feature of the first United Nations International Conference on the Peaceful Uses of Atomic Energy in 1955. Many scientists had doubted that a truly scientific meeting would be permitted by governments, and had predicted that science would be submerged by political propaganda. Could this United Nations initiative be a creative instrumentality toward realizing that 'Open World' which Niels Bohr advocated with such eloquence? The Conference fully lived up to Mr. Hammarskjold's hopes that it would inaugurate a new era in intercommunication. Participating scientists were enthusiastic over the opportunity for direct association and discussion in a professional atmosphere, without significant political intervention. To laymen everywhere, the knowledge that the world's scientific elite was exchanging information and ideas about nuclear energy, with the purpose of developing its potential benefits to mankind, was most heartening. Here was long-delayed evidence of international co-operation. Papers and seminars on pure science were, naturally enough, more in evidence than those on engineering applications, both because of the relative state of knowledge and because of reticence to disclose engineering 'know-how' to potential competitors. Furthermore, it is quite evident in retrospect that the prospects for economical nuclear power at an early date were over-estimated by the enthusiasts. Even so, the creation of a body of informed opinion was an essential step to stimulate further research, design and sound economic analysis for the eventual development of useful power from the atom. A most significant initiative of this Conference was the recruiting of an international group of scientists within the staff of the United Nations to plan, to guide and to operate the

  9. Assessment of the first conference

    International Nuclear Information System (INIS)

    Whitmann, W.G.

    1964-01-01

    Full text: (Professor Whitmann was Secretary-General of the 1955 Conference). The dramatic lifting of the Iron Curtain, which had for decades sealed off communication between East and West, was the outstanding feature of the first United Nations International Conference on the Peaceful Uses of Atomic Energy in 1955. Many scientists had doubted that a truly scientific meeting would be permitted by governments, and had predicted that science would be submerged by political propaganda. Could this United Nations initiative be a creative instrumentality toward realizing that 'Open World' which Niels Bohr advocated with such eloquence? The Conference fully lived up to Mr. Hammarskjold's hopes that it would inaugurate a new era in intercommunication. Participating scientists were enthusiastic over the opportunity for direct association and discussion in a professional atmosphere, without significant political intervention. To laymen everywhere, the knowledge that the world's scientific elite was exchanging information and ideas about nuclear energy, with the purpose of developing its potential benefits to mankind, was most heartening. Here was long-delayed evidence of international co-operation. Papers and seminars on pure science were, naturally enough, more in evidence than those on engineering applications, both because of the relative state of knowledge and because of reticence to disclose engineering 'know-how' to potential competitors. Furthermore, it is quite evident in retrospect that the prospects for economical nuclear power at an early date were over-estimated by the enthusiasts. Even so, the creation of a body of informed opinion was an essential step to stimulate further research, design and sound economic analysis for the eventual development of useful power from the atom. A most significant initiative of this Conference was the recruiting of an international group of scientists within the staff of the United Nations to plan, to guide and to operate the

  10. Embracing the future: Canada's nuclear renewal and growth. 28th annual conference of the Canadian Nuclear Society and 31st CNS/CNA student conference

    International Nuclear Information System (INIS)

    2007-01-01

    The 28th Annual Conference of the Canadian Nuclear Society and 31st CNS/CNA Student Conference was held on June 3-6, 2007 in Saint John, New Brunswick. The central objective of this conference was to provide a forum for exchange of views on how this technical enterprise can best serve the needs of humanity, now and in the future. 'Embracing the Future: Canada's Nuclear Renewal and Growth' was the theme for this year's gathering of nuclear industry experts from across Canada and around the world. This theme reflects the global renaissance of interest in nuclear technology, strongly evident here in Canada through plant refurbishments (underway and planned), new-build planning, renewal and expansion of the nuclear workforce, and growth in public support for environmentally sustainable technology. Topics for discussion at this conference include: the nuclear renaissance in Canada and around the world, recent developments at Canadian utilities, status of plant refurbishment and new build plans, and uranium supply issues. For business, energy, and science reporters this conference offers an insight into major nuclear projects and an opportunity to meet leaders in the nuclear sector. Over 100 technical papers were presented, as well as over 20 student papers, in the following sessions: control room operation; safety analyses; environment and waste management; plant life management and refurbishment; reactor physics; advanced reactor design; instrumentation control; general nuclear topics and standards; chemistry and materials; probabilistic safety assessment; and, performance improvement

  11. Pharmacologic ATM but not ATR kinase inhibition abrogates p21-dependent G1 arrest and promotes gastrointestinal syndrome after total body irradiation.

    Science.gov (United States)

    Vendetti, Frank P; Leibowitz, Brian J; Barnes, Jennifer; Schamus, Sandy; Kiesel, Brian F; Abberbock, Shira; Conrads, Thomas; Clump, David Andy; Cadogan, Elaine; O'Connor, Mark J; Yu, Jian; Beumer, Jan H; Bakkenist, Christopher J

    2017-02-01

    We show that ATM kinase inhibition using AZ31 prior to 9 or 9.25 Gy total body irradiation (TBI) reduced median time to moribund in mice to 8 days. ATR kinase inhibition using AZD6738 prior to TBI did not reduce median time to moribund. The striking finding associated with ATM inhibition prior to TBI was increased crypt loss within the intestine epithelium. ATM inhibition reduced upregulation of p21, an inhibitor of cyclin-dependent kinases, and blocked G1 arrest after TBI thereby increasing the number of S phase cells in crypts in wild-type but not Cdkn1a(p21 CIP/WAF1 )-/- mice. In contrast, ATR inhibition increased upregulation of p21 after TBI. Thus, ATM activity is essential for p21-dependent arrest while ATR inhibition may potentiate arrest in crypt cells after TBI. Nevertheless, ATM inhibition reduced median time to moribund in Cdkn1a(p21 CIP/WAF1 )-/- mice after TBI. ATM inhibition also increased cell death in crypts at 4 h in Cdkn1a(p21 CIP/WAF1 )-/-, earlier than at 24 h in wild-type mice after TBI. In contrast, ATR inhibition decreased cell death in crypts in Cdkn1a(p21 CIP/WAF1 )-/- mice at 4 h after TBI. We conclude that ATM activity is essential for p21-dependent and p21-independent mechanisms that radioprotect intestinal crypts and that ATM inhibition promotes GI syndrome after TBI.

  12. International Conference on Advanced Computing for Innovation

    CERN Document Server

    Angelova, Galia; Agre, Gennady

    2016-01-01

    This volume is a selected collection of papers presented and discussed at the International Conference “Advanced Computing for Innovation (AComIn 2015)”. The Conference was held at 10th -11th of November, 2015 in Sofia, Bulgaria and was aimed at providing a forum for international scientific exchange between Central/Eastern Europe and the rest of the world on several fundamental topics of computational intelligence. The papers report innovative approaches and solutions in hot topics of computational intelligence – advanced computing, language and semantic technologies, signal and image processing, as well as optimization and intelligent control.

  13. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation

    International Nuclear Information System (INIS)

    Alao, John P; Sunnerhagen, Per

    2009-01-01

    The ataxia telangiectasia mutated (ATM) and the ATM- related (ATR) kinases play a central role in facilitating the resistance of cancer cells to genotoxic treatment regimens. The components of the ATM and ATR regulated signaling pathways thus provide attractive pharmacological targets, since their inhibition enhances cellular sensitivity to chemo- and radiotherapy. Caffeine as well as more specific inhibitors of ATM (KU55933) or ATM and ATR (CGK733) have recently been shown to induce cell death in drug-induced senescent tumor cells. Addition of these agents to cancer cells previously rendered senescent by exposure to genotoxins suppressed the ATM mediated p21 expression required for the survival of these cells. The precise molecular pharmacology of these agents however, is not well characterized. Herein, we report that caffeine, CGK733, and to a lesser extent KU55933, inhibit the proliferation of otherwise untreated human cancer and non-transformed mouse fibroblast cell lines. Exposure of human cancer cell lines to caffeine and CGK733 was associated with a rapid decline in cyclin D1 protein levels and a reduction in the levels of both phosphorylated and total retinoblastoma protein (RB). Our studies suggest that observations based on the effects of these compounds on cell proliferation and survival must be interpreted with caution. The differential effects of caffeine/CGK733 and KU55933 on cyclin D1 protein levels suggest that these agents will exhibit dissimilar molecular pharmacological profiles

  14. XIX Edoardo Amaldi Conference

    CERN Document Server

    Abousahl, Said; Plastino, Wolfango

    2016-01-01

    This book, comprising contributions presented at the XIX Edoardo Amaldi Conference, examines important aspects of international cooperation aimed at enhancing nuclear safety, security, safeguards (the “3S”), and non-proliferation, thereby assisting in the development and maintenance of the verification regime and progress toward a nuclear weapon-free world. The Conference served as a forum where eminent scientists, diplomats, and policymakers could compare national perspectives and update international collaborations. The book opens by addressing the political, institutional, and legal dimensions of the 3S and non-proliferation; current challenges are discussed and attempts made to identify possible solutions and future improvements. Subsequent sections consider scientific developments that can contribute to increased effectiveness in the implementation of international regimes, particularly in critical areas, technology foresight, and the ongoing evaluation of current capabilities. The closing sections d...

  15. ATR-FTIR Spectroscopy Highlights the Problem of Distinguishing Between Exophiala dermatitidis and E. phaeomuriformis Using MALDI-TOF MS

    NARCIS (Netherlands)

    Ergin, C.; Gok, Y.; Baygu, Y.; Gumral, R.; Ozhak-Baysan, B.; Dogen, A.; Ogunc, D.; Ilkit, M.; Seyedmousavi, S.

    2016-01-01

    The present study compared two chemical-based methods, namely, matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, to understand the misidentification of Exophiala

  16. Atròfia muscular espinal: mecanismes patogènics i estratègies terapèutiques en models murins de la malaltia

    OpenAIRE

    Cerveró Cebrià, Clàudia

    2016-01-01

    L’atròfia muscular espinal (AME) és una malaltia genètica que cursa amb mort de motoneurones espinals i atròfia muscular. S’ha caracteritzat un model murí d’AME, l’Smn2B/-, amb una clínica menys severa que la mostrada per altres models més extensament utilitzats. S’ha evidenciat una alteració multisistèmica acompanyant a la clàssicament coneguda del sistema neuromuscular. S’han estudiat les sinapsis colinèrgiques tipus C en l’AME i testat el paper del PRE-084 (agonista del receptor sigm...

  17. New frontiers for tomorrow's world

    International Nuclear Information System (INIS)

    Kassler, P.

    1994-01-01

    The conference paper deals with new frontiers and barricades in the global economic development and their influence on fuel consumption and energy source development. Topics discussed are incremental energy supply - new frontiers, world car population - new frontiers, OPEC crude production capacity vs call on OPEC, incremental world oil demand by region 1992-2000, oil resource cost curve, progress in seismic 1983-1991, Troll picture, cost reduction in renewables, sustained growth scenario, nuclear electricity capacity - France, OECD road transport fuels - barricades, and energy taxation. 18 figs

  18. Fifth International Conference on Fission and Properties of Neutron-Rich Nuclei

    CERN Document Server

    Ramayya, A V; ICFN5

    2014-01-01

    These proceedings are the fifth in the series of International Conferences covering fission and properties of neutron-rich nuclei, which are at the forefront of nuclear research. The time interval of 5 years between each conference allows for significant new results to be achieved. Recently, world leaders in theory and experiments in research and the development of new facilities for research presented their latest results in areas such as synthesis of superheavy elements, new facilities for and recent results with radioactive ion beams, structure of neutron-rich nuclei, nuclear fission process, fission yields and nuclear astrophysics. This book is a major source of the latest research in these areas and plans for the future. The conference brought together a unique group of over 100 speakers including leaders from the major nuclear laboratories in Canada, China, France, Finland, Germany, Italy, Japan, Russia, Switerzland and the US along with leading research scientists from around the world.

  19. Population issues surface at human settlements conference.

    Science.gov (United States)

    1996-01-01

    This news brief focuses on the debate about population issues at the UN Conference on Human Settlements, held in Istanbul, Turkey, in June 1996. The Istanbul Declaration on Human Settlements was adopted by world leaders at the conference. Leaders were committed to programs to improve standards of living, the right of citizens to adequate housing, and the mobilization of new financial resources. Dr. Sadik, as Executive Director of the UN Population Fund, stressed that natural increase accounts for 60% of urban population growth. Mr. Boutros Boutros-Ghali, as UN Secretary General, stressed that over 50% of world population would live in urban centers by the year 2000, and almost 75% might do so by 2025. He indicated that all nations are interrelated; the poor and refugees from political conflict from one country travel to safer and richer countries. Dr. Sadik referred to the agreement at the 1994 International Conference on Population and Development (ICPD) on stabilizing world population in the shortest time possible. This would require meeting the needs of men and women for health, education, and the power of personal decision making. The most important item was the satisfaction of women's need for reproductive health information and services and women's power to use services. Dr. Sadik urged that women be given the right to hold and inherit property and to obtain credit. It was pointed out that the language of Habitat's plan of action on population and development issues was frequently bracketed; consequently, the plan suffered from a lack of consensus. The debate between countries would end, if the language were not bracketed. Dr. Sadik recommended family planning for developing sustainable and liveable cities.

  20. 5th European Turbulence Conference

    CERN Document Server

    1995-01-01

    Under the auspices of the Euromech Committee, the Fifth European Turbulence Conference was held in Siena on 5-8 July 1994. Following the previous ETC meeting in Lyon (1986), Berlin (1988), Stockholm (1990) and Delft (1992), the Fifth ETC was aimed at providing a review of the fundamental aspects of turbulence from a theoretical, numerical and experimental point of view. In the magnificent town of Siena, more than 250 scientists from all over the world, spent four days discussing new ideas on turbulence. As a research worker in the field of turbulence, I must say that the works presented at the Conference, on which this book is based, covered almost all areas in this field. I also think that this book provides a major opportunity to have a complete overview of the most recent research works. I am extremely grateful to Prof. C. Cercignani, Dr. M. Loffredo, and Prof. R. Piva who, as members of the local organizing committee, share the success of the Conference. I also want to thank Mrs. Liu' Catena, for her inva...

  1. 2005 annual nuclear technology conference

    International Nuclear Information System (INIS)

    Anon.

    2005-01-01

    This year's Annual Nuclear Technology Conference of the Deutsches Atomforum and Kerntechnische Gesellschaft was held in Nuremberg on May 10-12, 2005. More than 1 100 participants from eighteen countries make this specialized event one of the largest international conventions in the field of the peaceful uses of nuclear power, whose attendance has steadily increased over the past few years. The first day of the conference was devoted to plenary lectures traditionally dealing mainly with political and economic problems of the use of nuclear power. The partner country of JK 2005 was Switzerland. Traditionally, the program of the three-day conference was organized in the proven format of plenary sessions on the first day, followed by technical sessions, specialized sessions, poster sessions, and special events on the following days. For the third time, the ''Nuclear Campus'' was organized which successfully made the world of nuclear technology transparent to high school and university students in lectures and an exhibition. The meeting was accompanied by a technical exhibition with meeting points of manufacturers, suppliers, and service industries. (orig.)

  2. ATR-IR spectroscopic cell for in situ studies at solid-liquid interface at elevated temperatures and pressures

    NARCIS (Netherlands)

    Koichumanova, Kamila; Visan, Aura; Geerdink, Bert; Lammertink, Rob G.H.; Mojet, Barbara; Seshan, Kulathuiyer; Lefferts, Leonardus

    2017-01-01

    An in situ ATR-IR spectroscopic cell suitable for studies at solid-liquid interface is described including the design and experimental details in continuous flow mode at elevated temperatures (230 °C) and pressures (30 bar). The design parameters considered include the cell geometry, the procedure

  3. In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

    Science.gov (United States)

    Boulet-Audet, Maxime; Kazarian, Sergei G.; Byrne, Bernadette

    2016-01-01

    In recent years many monoclonal antibodies (mAb) have entered the biotherapeutics market, offering new treatments for chronic and life-threatening diseases. Protein A resin captures monoclonal antibody (mAb) effectively, but the binding capacity decays over repeated purification cycles. On an industrial scale, replacing fouled Protein A affinity chromatography resin accounts for a large proportion of the raw material cost. Cleaning-in-place (CIP) procedures were developed to extend Protein A resin lifespan, but chromatograms cannot reliably quantify any remaining contaminants over repeated cycles. To study resin fouling in situ, we coupled affinity chromatography and Fourier transform infrared (FTIR) spectroscopy for the first time, by embedding an attenuated total reflection (ATR) sensor inside a micro-scale column while measuring the UV 280 nm and conductivity. Our approach quantified the in-column protein concentration in the resin bed and determined protein conformation. Our results show that Protein A ligand leached during CIP. We also found that host cell proteins bound to the Protein A resin even more strongly than mAbs and that typical CIP conditions do not remove all fouling contaminants. The insights derived from in-column ATR-FTIR spectroscopic monitoring could contribute to mAb purification quality assurance as well as guide the development of more effective CIP conditions to optimise resin lifespan. PMID:27470880

  4. In-column ATR-FTIR spectroscopy to monitor affinity chromatography purification of monoclonal antibodies

    Science.gov (United States)

    Boulet-Audet, Maxime; Kazarian, Sergei G.; Byrne, Bernadette

    2016-07-01

    In recent years many monoclonal antibodies (mAb) have entered the biotherapeutics market, offering new treatments for chronic and life-threatening diseases. Protein A resin captures monoclonal antibody (mAb) effectively, but the binding capacity decays over repeated purification cycles. On an industrial scale, replacing fouled Protein A affinity chromatography resin accounts for a large proportion of the raw material cost. Cleaning-in-place (CIP) procedures were developed to extend Protein A resin lifespan, but chromatograms cannot reliably quantify any remaining contaminants over repeated cycles. To study resin fouling in situ, we coupled affinity chromatography and Fourier transform infrared (FTIR) spectroscopy for the first time, by embedding an attenuated total reflection (ATR) sensor inside a micro-scale column while measuring the UV 280 nm and conductivity. Our approach quantified the in-column protein concentration in the resin bed and determined protein conformation. Our results show that Protein A ligand leached during CIP. We also found that host cell proteins bound to the Protein A resin even more strongly than mAbs and that typical CIP conditions do not remove all fouling contaminants. The insights derived from in-column ATR-FTIR spectroscopic monitoring could contribute to mAb purification quality assurance as well as guide the development of more effective CIP conditions to optimise resin lifespan.

  5. [The medical French-speaking world].

    Science.gov (United States)

    Gouazé, André

    2002-01-01

    Medicine has always been and remains the most solid base of the French-speaking world which was born in Africa and Indochina with the admirable action of "colonial" military physicians, the implantation of the Pasteur Institutes and the emergence of resulting overseas medical schools. Obviously, we are referring to the French-speaking medical world. Since the first International Conference of the Deans of French-Speaking Medical Schools in Abidjan in 1981, today medical schools from 40 French-speaking countries participate. The conference undertakes co-operative medical school initiatives in a multi-lateral spirit, comprised by concrete, practical actions to assist universities in developing countries strive for excellence. These actions, which are conducted with the help of both institutional (AUF, MAE, WHO, UNESCO) and private partners mainly concentrate on promoting medical education of medicine, the evaluation of medical schools, the development of scientific and technical information and training teachers in the methodology of scientific clinical research and in public health. For the future, the Conference has three important objectives, to assist in training researchers and consequently in the development of research centres in emerging countries, to promote continuing medical education in rural areas far from medical schools by taking advantage of modern computer technology, and finally to open horizons toward other communities which speak other languages, and first of all, towards non French-speaking countries who live in a French-speaking environment.

  6. International conference in electrical engineering and intelligent systems

    CERN Document Server

    Gelman, Len; Electrical Engineering and Intelligent Systems

    2013-01-01

    The revised and extended papers collected in this volume represent the cutting-edge of research at the nexus of electrical engineering and intelligent systems. They were selected from well over 1000 papers submitted to the high-profile international World Congress on Engineering held in London in July 2011. The chapters cover material across the full spectrum of work in the field, including computational intelligence, control engineering, network management, and wireless networks. Readers will also find substantive papers on signal processing, Internet computing, high performance computing, and industrial applications.   The Electrical Engineering and Intelligent Systems conference, as part of the 2011 World Congress on Engineering was organized under the auspices of the non-profit International Association of Engineers (IAENG). With more than 30 nations represented on the conference committees alone, the Congress features the best and brightest scientific minds from a multitude of disciplines related to eng...

  7. END 2014: International Conference on Education and New Developments. Conference Proceedings (Madrid, Spain, June 28-30, 2014)

    Science.gov (United States)

    Carmo, Mafalda, Ed.

    2014-01-01

    We welcome you to the International Conference on Education and New Developments 2014, taking place in Madrid, Spain, from 28 to 30 of June, 2014. Education, as an important right in our contemporary world, began since we exist. Knowledge and skills were passed by adults to the young, and cultures began to extend their experiences through various…

  8. 2nd International Afro-European Conference for Industrial Advancement

    CERN Document Server

    Wegrzyn-Wolska, Katarzyna; Hassanien, Aboul; Snasel, Vaclav; Alimi, Adel

    2016-01-01

    This volume contains papers presented at the 2nd International Afro-European Conference for Industrial Advancement -- AECIA 2015. The conference aimed at bringing together the foremost experts and excellent young researchers from Africa, Europe and the rest of the world to disseminate the latest results from various fields of engineering, information, and communication technologies. The topics, discussed at the conference, covered a broad range of domains spanning from ICT and engineering to prediction, modeling, and analysis of complex systems. The 2015 edition of AECIA featured a distinguished special track on prediction, modeling and analysis of complex systems -- Nostradamus, and special sessions on Advances in Image Processing and Colorization and Data Processing, Protocols, and Applications in Wireless Sensor Networks.

  9. 5th CIRP international conference on industrial product-service systems

    CERN Document Server

    2013-01-01

    “An Industrial Product-Service System is characterized by the integrated and mutually  determined planning, development, provision and use of product and service shares including its immanent software components in Business-to-Business applications and represents a knowledge-intensive socio-technical system.” – Meier, Roy, Seliger (2010) Since the first conference in 2009, the CIRP International Conference on Industrial Product-Service Systems has become a well-established international forum for the review and discussion of advances, research results and industrial improvements. Researchers from all over the world have met at previous IPS² conferences in Cranfield (2009), Linköping (2010), Braunschweig (2011) and Tokyo (2012). In 2013, the 5th CIRP International Conference on Industrial Product-Service Systems is held in Bochum. Important topics of IPS² research presented at the conference are: planning and development, sustainability, business models, operation, service engineering, knowledge mana...

  10. Modeling Microalgal Biosediment Formation Based on Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Monitoring.

    Science.gov (United States)

    Ogburn, Zachary L; Vogt, Frank

    2018-03-01

    With increasing amounts of anthropogenic pollutants being released into ecosystems, it becomes ever more important to understand their fate and interactions with living organisms. Microalgae play an important ecological role as they are ubiquitous in marine environments and sequester inorganic pollutants which they transform into organic biomass. Of particular interest in this study is their role as a sink for atmospheric CO 2 , a greenhouse gas, and nitrate, one cause of harmful algal blooms. Novel chemometric hard-modeling methodologies have been developed for interpreting phytoplankton's chemical and physiological adaptations to changes in their growing environment. These methodologies will facilitate investigations of environmental impacts of anthropogenic pollutants on chemical and physiological properties of marine microalgae (here: Nannochloropsis oculata). It has been demonstrated that attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy can gain insights into both and this study only focuses on the latter. From time-series of spectra, the rate of microalgal biomass settling on top of a horizontal ATR element is derived which reflects several of phytoplankton's physiological parameters such as growth rate, cell concentrations, cell size, and buoyancy. In order to assess environmental impacts on such parameters, microalgae cultures were grown under 25 different chemical scenarios covering 200-600 ppm atmospheric CO 2 and 0.35-0.75 mM dissolved NO 3 - . After recording time-series of ATR FT-IR spectra, a multivariate curve resolution-alternating least squares (MCR-ALS) algorithm extracted spectroscopic and time profiles from each data set. From the time profiles, it was found that in the considered concentration ranges only NO 3 - has an impact on the cells' physiological properties. In particular, the cultures' growth rate has been influenced by the ambient chemical conditions. Thus, the presented spectroscopic

  11. Student Support for EIPBN 2014 Conference - Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Farrow, Reginald C.

    2014-09-16

    The 58th International Conference on Electron, Ion and Photon Beam Technology and Nanofabrication (EIPBN), 2014, was held at the Omni Shoreham Hotel in Washington, DC, May 27 to 30, 2014. The EIPBN Conference is recognized as the foremost international meeting dedicated to lithographic science and technology and its application to micro and nanofabrication techniques. The conference brought together 386 engineers and scientists from industries and universities from all over the world to discuss recent progress and future trends. Among the emerging technologies that are within the scope of EIPBN is Nanofabrication for Energy Sources along with nanofabrication for the realization of low power integrated circuits. Every year, EIPBN provides financial support for students to attend the conference. Travel support for 43 students came from a mixture of government agencies and corporate donors. The Department of Energy Office of Basic Energy Sciences provided $5,000 to support student travel from US universities to participate at EIPBN 2014 through grant DE-SC0011789.

  12. Optical fingerprints of solid-liquid interfaces: a joint ATR-IR and first principles investigation

    Science.gov (United States)

    Yang, L.; Niu, F.; Tecklenburg, S.; Pander, M.; Nayak, S.; Erbe, A.; Wippermann, S.; Gygi, F.; Galli, G.

    Despite the importance of understanding the structural and bonding properties of solid-liquid interfaces for a wide range of (photo-)electrochemical applications, there are presently no experimental techniques available to directly probe the microscopic structure of solid-liquid interfaces. To develop robust strategies to interpret experiments and validate theory, we carried out attenuated total internal reflection (ATR-IR) spectroscopy measurements and ab initio molecular dynamics (AIMD) simulations of the vibrational properties of interfaces between liquid water and well-controlled prototypical semiconductor substrates. We show the Ge(100)/H2O interface to feature a reversible potential-dependent surface phase transition between Ge-H and Ge-OH termination. The Si(100)/H2O interface is proposed as a model system for corrosion and oxidation processes. We performed AIMD calculations under finite electric fields, revealing different pathways for initial oxidation. These pathways are predicted to exhibit unique spectral signatures. A significant increase in surface specificity can be achieved utilizing an angle-dependent ATR-IR experiment, which allows to detect such signatures at the interfacial layer and consequently changes in the hydrogen bond network. Funding from DOE-BES Grant No. DE-SS0008939 and the Deutsche Forschungsgemeinschaft (RESOLV, EXC 1069) are gratefully acknowledged.

  13. Characterization of Satsuma mandarin (Citrus unshiu Marc.) nectar-to-honey transformation pathway using FTIR-ATR spectroscopy.

    Science.gov (United States)

    Svečnjak, Lidija; Prđun, Saša; Rogina, Josip; Bubalo, Dragan; Jerković, Igor

    2017-10-01

    Samples of Satsuma mandarin (Citrus unshiu Marc.) nectar, honey sac content and honey were analyzed by FTIR-ATR spectroscopy and reference methods. The spectral analysis allowed detection of the major chemical constituents in C. unshiu nectar-to-honey transformation pathway thus providing information on the intensity and location of the compositional changes occurring during this process. The preliminary results showed that in average more than one-third of sugar-related nectar-to-honey conversion takes place directly in the honey sac; the average sugar content (w/w) was 17.93% (nectar), 47.03% (honey sac) and 79.63% (honey). FTIR-ATR results showed great spectral similarity of analyzed honey samples and small degree variations in both sugar and water content in nectar samples. The spectral data revealed distinctive differences in the chemical composition of individual honey sac contents with the most intensive and complex absorption envelope in the spectral region between 1175 and 950cm -1 (glucose, fructose and sucrose absorption bands). Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Encefalomenigocele atrésico parietal Parietal atresic encephalomeningocele

    Directory of Open Access Journals (Sweden)

    Liliana Rivera Oliva

    2011-09-01

    Full Text Available El encefalocele es una anomalía congénita rara, en la que una porción del encéfalo protruye a través de un orificio craneal (evaginación, generalmente situado en la línea media. Clínicamente se caracteriza por una masa epicraneal, de consistencia blanda, muchas veces acompañada de trastornos psicomotores, convulsiones y trastornos de la visión. Se presenta el caso de un recién nacido con diagnóstico de encefalomeningocele atrésico parietal, intervenido quirúrgicamente y con evolución satisfactoria.The encephalocele is a uncommon congenital anomaly where a portion of encephalon protrudes through a cranial orifice (evagination, generally located in the middle line. Clinically, it is characterized by a soft epicranial mass often accompanied or psychomotor disorders, convulsions and vision disorders. This is the case of a newborn diagnosed with parietal atresic encephalomeningocele operated on with a satisfactory evolution.

  15. Conference on Geometric Analysis &Conference on Type Theory, Homotopy Theory and Univalent Foundations : Extended Abstracts Fall 2013

    CERN Document Server

    Yang, Paul; Gambino, Nicola; Kock, Joachim

    2015-01-01

    The two parts of the present volume contain extended conference abstracts corresponding to selected talks given by participants at the "Conference on Geometric Analysis" (thirteen abstracts) and at the "Conference on Type Theory, Homotopy Theory and Univalent Foundations" (seven abstracts), both held at the Centre de Recerca Matemàtica (CRM) in Barcelona from July 1st to 5th, 2013, and from September 23th to 27th, 2013, respectively. Most of them are brief articles, containing preliminary presentations of new results not yet published in regular research journals. The articles are the result of a direct collaboration between active researchers in the area after working in a dynamic and productive atmosphere. The first part is about Geometric Analysis and Conformal Geometry; this modern field lies at the intersection of many branches of mathematics (Riemannian, Conformal, Complex or Algebraic Geometry, Calculus of Variations, PDE's, etc) and relates directly to the physical world, since many natural phenomena...

  16. A hydrogen economy: an answer to future energy problems. [Overview of 1974 THEME Conference

    Energy Technology Data Exchange (ETDEWEB)

    Seifritz, W [Eidgenoessisches Inst. fuer Reaktorforschung, Wuerenlingen (Switzerland)

    1975-06-01

    ''The Theme was THEME''. This was the headline of The Hydrogen Economy Miami Energy Conference which was the first international conference of this type and which took place in Miami, March 18-20, 1974. For the first time, about 700 participants from all over the western world discussed all the ramifications and aspects of a hydrogen based economy. Non-fossil hydrogen, produced from water by either electrolysis or by direct use of process heat from a nuclear source is a clean, all-synthetic, automatically recyclable, and inexhaustible fuel. It may support the World's future energy requirements beyond the present self limited fossil-fuel era. A large number of papers and news were presented on this conference reflecting this effort. The following article is intended to report on the highlights of the conference and to give a survey on the present state of the art in the hydrogen field. Furthermore, the author includes his own ideas and conclusions predominantly by taking into account the trends in the development of future nuclear reactor systems and symbiotic high-temperature-reactor/breeder strategies being the primary energy input of a hydrogen economy and providing a most promising avenue for solving both the World's energy and environmental (entropy) problems.

  17. Measured thermal and fast neutron fluence rates for ATF-1 holders during ATR cycle 158B/159A

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Larry Don [Idaho National Lab. (INL), Idaho Falls, ID (United States); Miller, David Torbet [Idaho National Lab. (INL), Idaho Falls, ID (United States); Walker, Billy Justin [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-11-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for the ATF-1 holders located in core for ATR Cycle 158B/159A which were measured by the Radiation Measurements Laboratory (RML).

  18. Atomic Physics 16: Sixteenth International Conference on Atomic Physics. Proceedings

    International Nuclear Information System (INIS)

    Baylis, W.E.; Drake, G.W.

    1999-01-01

    These proceedings represent papers presented at the 16th International Conference on Atomic Physics held in Windsor, Ontario, Canada, in August, 1998. The topics discussed included a wide array of subjects in atomic physics such as atom holography, alignment in atomic collisions, coulomb-interacting particles, muon experiments, x-rays from comets, atomic electron collisions in intense laser fields, spectroscopy of trapped ions, and Bose-Einstein condensates. This conference represents the single most important meeting world wide on fundamental advances in atomic physics. There were 30 papers presented at the conference,out of which 4 have been abstracted for the Energy, Science and Technology database

  19. [International conference on population and development in Cairo].

    Science.gov (United States)

    van Enk, A

    1994-11-05

    The UN Conference on Population and Development was held in Cairo in September 1994, and dealt with a range of sensitive issues that were eventually recorded in an action program. In addition, a sort of shadow conference was also held by various organizations. The precedents of this conference were the conferences held in Bucharest in 1974, which stressed the world crisis and population explosion, and in Mexico in 1984, where the first signs of the slackening of population growth induced less emphasis on family planning programs and more on the status of women. At Cairo again a crisis atmosphere reigned because rapid population growth has not been followed by rapid development. Birth control discussions also focused on ethical and religious norms, human rights, and emancipation problems. Most of all, the sustainability of development programs was stressed. Global decline of mortality combined with a continuing high birth rate has resulted in a population growth of 3% or more. In the course of 40 years the growth was 46% in industrialized countries as compared to 161% in the poorest lands. The total world population has reached 5 billion, of which only 20% live industrial countries. The influence of the AIDS epidemic on the demographic figures is not likely to be as much as anticipated a few years ago. Other problems are demographic aging, population decline (a below replacement fertility rate in Japan, Spain, and Italy), and uncontrolled internal and international migration (refugees in developing countries and flight to major cities). In the next 30 years almost two-thirds of the population of developing countries will be living in shabby, sprawling megacities. In 1989, in preparation for the Cairo conference, an international forum was held in Amsterdam on population. It dealt with the reproductive rights of women, the negative impact of structural readjustment programs on family planning, and the priority of women's education.

  20. Cairo conference to link population and sustainable development.

    Science.gov (United States)

    1994-09-01

    Couples who want to limit the size of their families but whom family planning services elude are a key factor in the persistence of high rates of fertility and rapid population growth in some countries of the Asian and Pacific region (ESCAP). High fertility and rapid growth are linked to high rates of maternal and child mortality, poverty, and increasing pressure on the environment. These issues will be considered at the International Conference on Population and Development at Cairo from 5 to 13 September, 1994. The Conference objectives entail the promotion of more effective national programs to meet individual needs of women, and to bring population into balance with available resources. The Conference is expected to adopt a program of action covering the period 1995-2015. A preparatory meeting, the Fourth Asian and Pacific Population Conference, adopted the Bali Declaration on Population and Development as a blueprint for ESCAP region countries. Unprecedented growth in human numbers, widespread poverty, social and economic in equality and wasteful consumption are accelerating the depletion of resources and environmental degradation. Rural-to-urban migration will also be major concerns at the Conference. Real poverty and unemployment are the leading causes of urbanization. Recent United Nations data show that by 2005 half the world's population will be urban. Development policies affecting the rural work-force need to emphasize gender equity and access to land tenure and credit. Economic growth and improvement in the quality of life have been fastest in those areas where the status of women is highest, therefore population policies will succeed only if women are equal to men in making and directing policy. The draft Program of Action would commit the world community to goals in education, especially for girls; reduction of infant, child and maternal mortality; and universal access to family planning and reproductive health services.

  1. Proceedings of the 6. international green energy conference IGEC-6

    Energy Technology Data Exchange (ETDEWEB)

    Karakoc, T.H.; Midilli, A.; Turan, O.; Orman, E.; Tunca, F.; Yazar, I. (eds.) [School of Civil Aviation, Anadolu University, Eskisehir (Turkey)

    2011-07-01

    The 6th International Green Energy Conference (IGEC) took place in Eskisehir, Turkey, from June 5 to June 9, 2011 and was organized by the International Association for Green Energy and Anadolu University. The IGEC is a multi-disciplinary international conference on the use of energy with reduced environmental impacts. Around 150 experts from all over the world attended and presentations were given on energy diversity, energy localization, energy security and sustainable development. The conference provided these experts with an opportunity to hear about studies done by their peers, gather and discuss the latest technical information and research results, and to debate future directions and priorities in sustainable development and energy security. All 124 papers presented during the conference have been catalogued separately for inclusion in this database.

  2. International conference on individual monitoring of ionising radiation

    International Nuclear Information System (INIS)

    Vanhavere, Filip

    2016-01-01

    This special issue of the journal Radiation Protection Dosimetry is dedicated to the Proceedings of the International Conference on Individual Monitoring of Ionising Radiation (IM2015), which is the fifth of a series of conferences dealing with individual monitoring. This conference series is initiated by EURADOS, the European Radiation Dosimetry Group, and is organised every 5 years. In 2015, the conference was jointly organised by the Belgian Nuclear Research Centre (SCK.CEN), AV Controlatom, and the Vrije Universiteit Brussel. It brought together scientists from regulatory authorities, individual monitoring services (IMS), research bodies, European networks and companies, for the purpose of facilitating the dissemination of knowledge, exchanging experiences and promoting new ideas in the field of individual monitoring. After the conference, 124 papers were submitted for publication in these peer-reviewed proceedings. From these, 103 were finally accepted for publication. The help of the numerous referees and the guest editors is very much appreciated. These proceedings provide a full image of the IM2015 conference. The high-level publications will be useful to improve the state of individual monitoring all over the world and aim to inspire many scientists to continue their work on a better monitoring of radiologically exposed workers

  3. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy

    DEFF Research Database (Denmark)

    Barsberg, Søren Talbro; Lee, Y.-I.; Rasmussen, Hanne Nina

    2018-01-01

    Cite this article: Barsberg ST, Lee Y-I, Rasmussen HN. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy. Seed Science Research https:// doi.org/10.1017/S0960258517000344......Cite this article: Barsberg ST, Lee Y-I, Rasmussen HN. Development of C-lignin with G/S-lignin and lipids in orchid seed coats – an unexpected diversity exposed by ATR-FT-IR spectroscopy. Seed Science Research https:// doi.org/10.1017/S0960258517000344...

  4. 12th Europhysical Conference on Defects in Insulating Materials (EURODIM 2014)

    International Nuclear Information System (INIS)

    Alfredsson, M L; Chadwick, A V; Jackson, R A; McCabe, E E

    2015-01-01

    The 12th Europhysical Conference on Defects in Insulating Materials (EURODIM14) was held at the University of Kent, UK, from 13-18 July 2014. It was attended by about 120 delegates from around the world, and featured 56 oral presentations and 77 posters. EURODIM14 followed other conferences in the series, held in Pecs (2010), Milan (2006) and Wroclaw (2002), as well as the related ICDIM conferences held in Santa Fe (2012), Aracaju (2008) and Riga (2004). These conferences all have the aim of bringing together scientists to discuss the chemistry and physics of defects in solids, and their role in determining material properties. We would like to thank the International Advisory Committee for suggesting invited speakers, and the Local and Programme Committee for their hard work in planning and running the conference. Finally we would like to thank the authors and referees for their contributions to the proceedings. M L Alfredsson (Conference Chair) A V Chadwick R A Jackson E E McCabe (preface)

  5. 5th Computer Science On-line Conference

    CERN Document Server

    Senkerik, Roman; Oplatkova, Zuzana; Silhavy, Petr; Prokopova, Zdenka

    2016-01-01

    This volume is based on the research papers presented in the 5th Computer Science On-line Conference. The volume Artificial Intelligence Perspectives in Intelligent Systems presents modern trends and methods to real-world problems, and in particular, exploratory research that describes novel approaches in the field of artificial intelligence. New algorithms in a variety of fields are also presented. The Computer Science On-line Conference (CSOC 2016) is intended to provide an international forum for discussions on the latest research results in all areas related to Computer Science. The addressed topics are the theoretical aspects and applications of Computer Science, Artificial Intelligences, Cybernetics, Automation Control Theory and Software Engineering.

  6. International Asia Conference on Industrial Engineering and Management Innovation

    CERN Document Server

    Shen, Jiang; Dou, Runliang

    2013-01-01

    The International Conference on Industrial Engineering and Engineering Management is sponsored by the Chinese Industrial Engineering Institution, CMES, which is the only national-level academic society for Industrial Engineering. The conference is held annually as the major event in this arena. Being the largest and the most authoritative international academic conference held in China, it provides an academic platform for experts and entrepreneurs in the areas of international industrial engineering and management to exchange their research findings. Many experts in various fields from China and around the world gather together at the conference to review, exchange, summarize and promote their achievements in the fields of industrial engineering and engineering management. For example, some experts pay special attention to the current state of the application of related techniques in China as well as their future prospects, such as green product design, quality control and management, supply chain and logist...

  7. Rapid quantification of TBP and TBP degradation product ratios by FTIR-ATR

    International Nuclear Information System (INIS)

    Gillens, A.R.; Powell, B.A.; Clemson University, Clemson, SC

    2013-01-01

    Tri-n-butyl phosphate (TBP) is the key complexant within the plutonium and uranium reduction extraction process used to extract uranium and plutonium from used nuclear fuel. During reprocessing TBP degrades to dibutyl phosphate (DBP), butyl acid phosphate (MBP), butanol, and phosphoric acid over time. A method for rapidly monitoring TBP degradation is needed for the support of nuclear forensics. Therefore, a Fourier transform infrared spectrometry-attenuated total reflectance (FTIR-ATR) technique was developed to determine approximate peak intensity ratios of TBP and its degradation products. The technique was developed by combining variable concentrations of TBP, DBP, and MBP to simulate TBP degradation. This method is achieved by analyzing selected peak positions and peak intensity ratios of TBP and DBP at different stages of degradation. The developed technique was tested on TBP samples degraded with nitric acid. In mock degradation samples, the 1,235 cm -1 peak position shifts to 1,220 cm -1 as the concentration of TBP decreases and DBP increases. Peak intensity ratios of TBP positions at 1,279 and 1,020 cm -1 relative to DBP positions at 909 and 1,003 cm -1 demonstrate an increasing trend as the concentration of DBP increases. The same peak intensity ratios were used to analyze DBP relative to MBP whereas a decreasing trend is seen with increasing DBP concentrations. The technique developed from this study may be used as a tool to determine TBP degradation in nuclear reprocessing via a rapid FTIR-ATR measurement without gas chromatography analysis. (author)

  8. The All-Russian Scientific Conference “The Ananyino World: Sources, Development, Interrelations, Historical Destinies”

    Directory of Open Access Journals (Sweden)

    Kuzminykh Sergey V.

    2012-06-01

    Full Text Available The report on the conference, which was held in Bolgar (the Republic of Tatarstan in November, 2012, and dedicated to the Ananyino cultural and historical community, is presented. A wide range of problems related to the final Bronze Age and the Early Iron Age in the forest-steppe zone of European Russia, the Urals and Western Siberia were considered. Special attention was paid to the intercultural relations of the time. The results of the latest research in the field, including broad historical and cultural generalizations, are presented. It was decided to publish the materials contributed, and to hold future similar conferences at 3-4- years’ intervals.

  9. In-line ATR-UV and Raman Spectroscopy for Monitoring API Dissolution Process During Liquid-Filled Soft-Gelatin Capsule Manufacturing.

    Science.gov (United States)

    Wan, Boyong; Zordan, Christopher A; Lu, Xujin; McGeorge, Gary

    2016-10-01

    Complete dissolution of the active pharmaceutical ingredient (API) is critical in the manufacturing of liquid-filled soft-gelatin capsules (SGC). Attenuated total reflectance UV spectroscopy (ATR-UV) and Raman spectroscopy have been investigated for in-line monitoring of API dissolution during manufacturing of an SGC product. Calibration models have been developed with both techniques for in-line determination of API potency. Performance of both techniques was evaluated and compared. The ATR-UV methodology was found to be able to monitor the dissolution process and determine the endpoint, but was sensitive to temperature variations. The Raman technique was also capable of effectively monitoring the process and was more robust to the temperature variation and process perturbations by using an excipient peak for internal correction. Different data preprocessing methodologies were explored in an attempt to improve method performance.

  10. ATR-FTIR Spectroscopy on intact dried leaves of sage (Salvia officinalis L. – chemotaxonomic discrimination and essential oil composition

    Directory of Open Access Journals (Sweden)

    Gudi, Gennadi

    2016-07-01

    Full Text Available Sage (Salvia officinalis L. is cultivated worldwide for its aromatic leaves which are used as herbal spice and for phytopharmaceutical applications. Fast analytical strategies for essential oil analysis, performed directly on plant material would reduce the delay between sampling and analytical results. This would enhance product quality by improving technical control of cultivation. The attenuated total reflectance Fourier transform infrared (ATR-FTIR spectroscopy method described here provides a reliable calibration model for quantification of essential oil components (EOC and its main constituents (e.g. -thujone and -thujone directly on dried, intact leaves of sage. Except for drying no further sample preparation is required for ATR-FTIR and the measurement time of less than 5 min per sample contrasts with the most common alternative of hydro-distillation followed by GC analysis which can take several hours per sample.

  11. International conference, future of coal in the economy of the world and Poland; Miedzynarodowa konferencja. Przyszlosc wegla w gospodarce swiata i Polski Miedzynarodowa konferencja. Przyszlosc wegla w gospodarce swiata i Polski

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2004-07-01

    The conference was held in three sessions entitled: coal as an important element of sustained development of the world energy development; problems of hard and brown coal mining development; and hard and brown coal reserves, their utilization and environmental protection. A total of seventeen papers were presented and are contained in the proceedings. Each has been abstracted separately for the Coal Abstracts database.

  12. END 2015: International Conference on Education and New Developments. Conference Proceedings (Porto, Portugal, June 27-29, 2015)

    Science.gov (United States)

    Carmo, Mafalda, Ed.

    2015-01-01

    We are delighted to welcome you to the International Conference on Education and New Developments 2015-END 2015, taking place in Porto, Portugal, from 27 to 29 of June. Education, in our contemporary world, is a right since we are born. Every experience has a formative effect on the constitution of the human being, in the way one thinks, feels and…

  13. END 2016: International Conference on Education and New Developments. Conference Proceedings (Ljubljana, Slovenia, June 12-14, 2016)

    Science.gov (United States)

    Carmo, Mafalda, Ed.

    2016-01-01

    We are delighted to welcome you to the International Conference on Education and New Developments 2016--END 2016, taking place in Ljubljana, Slovenia, from 12 to 14 of June. Education, in our contemporary world, is a right since we are born. Every experience has a formative effect on the constitution of the human being, in the way one thinks,…

  14. Proceedings of the Adult Higher Education Alliance Annual Conference (35th, Orlando, Florida, March 10-11, 2015)

    Science.gov (United States)

    Elufiede, Oluwakemi, Ed.; Flynn, Bonnie, Ed.

    2015-01-01

    This document contains the proceedings of The Adult Higher Education Alliance 35th Annual Conference. The theme of the conference was Adult and Higher Education in the Contemporary World: Its Role In Cultural Literacy. The conference was held on March 10-11, 2015. The event was hosted by and held at the College of Education and Human Performance,…

  15. Glycation in human fingernail clippings using ATR-FTIR spectrometry, a new marker for the diagnosis and monitoring of diabetes mellitus.

    Science.gov (United States)

    Coopman, Renaat; Van de Vyver, Thijs; Kishabongo, Antoine Sadiki; Katchunga, Philippe; Van Aken, Elisabeth H; Cikomola, Justin; Monteyne, Tinne; Speeckaert, Marijn M; Delanghe, Joris R

    2017-01-01

    Although HbA1c is a good diagnostic tool for diabetes, the precarity of the health system and the costs limit the use of this biomarker in developing countries. Fingernail clippings contain ±85% of keratins, which are prone to glycation. Nail keratin glycation may reflect the average glycemia over the last months. We explored if attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) can be used as a non-invasive tool for assessing glycation in diabetes. Using ATR-FTIR spectroscopy, glycation and deglycation experiments with fructosamine 3-kinase allowed to identify the spectrum that corresponds with keratin glycation in fingernail clippings. Clippings of 105 healthy subjects and 127 diabetics were subjected to the standardized ATR-FTIR spectroscopy method. In vitro glycation resulted in an increased absorption at 1047cm -1 . Following enzymatic deglycation, this peak diminished significantly, proving that the AUC between 970 and 1140cm -1 corresponded with glycated proteins. Within-run CV of the assay was 3%. Storage of nail clippings at 37°C for 2weeks did not significantly change results. In diabetics, glycated nail protein concentrations (median: 1.51μmol/g protein, IQR: 1.37-1.85μmol/g protein) were significantly higher than in the controls (median: 1.19μmol/g protein, IQR: 1.09-1.26μmol/g protein) (p<0.0001). ROC analysis yielded an AUC of 0.92 at a cut-off point of 1.28μmol/g nail (specificity: 82%; sensitivity: 90%). No correlation was observed between the glycated nail protein concentrations and HbA1c. Protein glycation analysis in fingernails with ATR-FTIR spectroscopy could be an alternative affordable technique for diagnosing and monitoring diabetes. As the test does not consume reagents, and the preanalytical phase is extremely robust, the test could be particularly useful in developing countries. Copyright © 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  16. Statement to Conference for a Nuclear-Weapons-Free World, 12 October 2011, Astana, Kazakhstan

    International Nuclear Information System (INIS)

    Amano, Y.

    2011-01-01

    Full text: It is a great honour for me to address this Conference for a Nuclear-Weapons-Free World. Astana is a highly appropriate venue for this Conference. Kazakhstan has made a very important contribution to nuclear non-proliferation and disarmament. Under the leadership of President Nursultan Nazarbayev, Kazakhstan renounced the nuclear weapons which it inherited from the Soviet Union and closed the Semipalatinsk Nuclear Test Site, where over 450 underground and atmospheric nuclear tests had been conducted. It joined the Treaty on the Non-Proliferation of Nuclear Weapons (NPT) as a non-nuclear-weapon State and has concluded both a safeguards agreement and an additional protocol with the IAEA. Kazakhstan played a significant role in establishing a nuclear-weapon-free zone in Central Asia in 2009. The treaty creating this nuclear-weapon-free zone established an important precedent as it is the only arms control treaty to date that requires its parties to bring into force an additional protocol to their IAEA safeguards agreements. The treaty, which was supported by the IAEA, forbids the development, manufacture, stockpiling, acquisition or possession of any nuclear explosive device within the zone. Peaceful uses of nuclear energy are permitted if placed under enhanced IAEA safeguards. The treaty also requires Parties to meet international standards regarding security of nuclear facilities. This is intended to reduce the risk of nuclear terrorism and prevent smuggling of nuclear and radioactive materials in the region. Today, the scientific and technical facilities at Semipalatinsk are being converted to peaceful uses under the jurisdiction of the National Nuclear Centre of the Republic of Kazakhstan. IAEA is pleased to have assisted in this work. Shutting down the nuclear test range at Semipalatinsk sends a strong signal of support for the nuclear non-proliferation and disarmament regime. It contributes both directly and symbolically to the goals of the

  17. The Second Joint NASA/FAA/DOD Conference on Aging Aircraft. Pt. 1

    Science.gov (United States)

    Harris, Charles E. (Editor)

    1999-01-01

    The purpose of the Conference was to bring together world leaders in aviation safety research, aircraft design and manufacturing, fleet operation and aviation maintenance to disseminate information on current practices and advanced technologies that will assure the continued airworthiness of the aging aircraft in the military and commercial fleets. The Conference included reviews of current industry practices, assessments of future technology requirements, and status of aviation safety research. The Conference provided an opportunity for interactions among the key personnel in the research and technology development community, the original equipment manufacturers, commercial airline operators, military fleet operators, aviation maintenance, and aircraft certification and regulatory authorities. Conference participation was unrestricted and open to the international aviation community.

  18. Rapid, nondestructive estimation of surface polymer layer thickness using attenuated total reflection fourier transform infrared (ATR FT-IR) spectroscopy and synthetic spectra derived from optical principles.

    Science.gov (United States)

    Weinstock, B André; Guiney, Linda M; Loose, Christopher

    2012-11-01

    We have developed a rapid, nondestructive analytical method that estimates the thickness of a surface polymer layer with high precision but unknown accuracy using a single attenuated total reflection Fourier transform infrared (ATR FT-IR) measurement. Because the method is rapid, nondestructive, and requires no sample preparation, it is ideal as a process analytical technique. Prior to implementation, the ATR FT-IR spectrum of the substrate layer pure component and the ATR FT-IR and real refractive index spectra of the surface layer pure component must be known. From these three input spectra a synthetic mid-infrared spectral matrix of surface layers 0 nm to 10,000 nm thick on substrate is created de novo. A minimum statistical distance match between a process sample's ATR FT-IR spectrum and the synthetic spectral matrix provides the thickness of that sample. We show that this method can be used to successfully estimate the thickness of polysulfobetaine surface modification, a hydrated polymeric surface layer covalently bonded onto a polyetherurethane substrate. A database of 1850 sample spectra was examined. Spectrochemical matrix-effect unknowns, such as the nonuniform and molecularly novel polysulfobetaine-polyetherurethane interface, were found to be minimal. A partial least squares regression analysis of the database spectra versus their thicknesses as calculated by the method described yielded an estimate of precision of ±52 nm.

  19. Eleventh CERI [Canadian Energy Research Inst.] international oil and gas markets conference

    International Nuclear Information System (INIS)

    1992-01-01

    At a conference on international oil and gas markets, papers were presented on world oil and gas markets; energy policies; regulatory policies; supply and demand scenarios; environmental issues; the markets and industries in individual countries such as the former Soviet Union, USA, Canada, and the United Kingdom; business strategies; geopolitics of energy; and coalbed methane supplies. Separate abstracts have been prepared for 22 papers from this conference

  20. World interest in nuclear desalination

    International Nuclear Information System (INIS)

    1969-01-01

    Nuclear power will be used in a desalination plant for the first time in a USSR plant now nearing completion. Studies are in progress to expand the concept of linking the power to chemical industries. These and other developing ideas were subjects of keen discussion by world experts at an Agency conference on nuclear desalination in Madrid. (author)

  1. The World Wide Web as a Medium of Instruction: What Works and What Doesn't

    Science.gov (United States)

    McCarthy, Marianne; Grabowski, Barbara; Hernandez, Angel; Koszalka, Tiffany; Duke, Lee

    1997-01-01

    A conference was held on March 18-20, 1997 to investigate the lessons learned by the Aeronautics Cooperative Agreement Projects with regard to the most effective strategies for developing instruction for the World Wide Web. The conference was a collaboration among the NASA Aeronautics and Space Transportation Technology Centers (Ames, Dryden, Langley, and Lewis), NASA Headquarters, the University of Idaho and The Pennsylvania State University. The conference consisted of presentations by the Aeronautics Cooperative Agreement Teams, the University of Idaho, and working sessions in which the participants addressed teacher training and support, technology, evaluation and pedagogy. The conference was also undertaken as part of the Dryden Learning Technologies Project which is a collaboration between the Dryden Education Office and The Pennsylvania State University. The DFRC Learning Technology Project goals relevant to the conference are as follows: conducting an analysis of current teacher needs, classroom infrastructure and exemplary instructional World Wide Web sites, and developing models for Web-enhanced learning environments that optimize teaching practices and student learning.

  2. Major Roles for Pyrimidine Dimers, Nucleotide Excision Repair, and ATR in the Alternative Splicing Response to UV Irradiation

    Directory of Open Access Journals (Sweden)

    Manuel J. Muñoz

    2017-03-01

    Full Text Available We have previously found that UV irradiation promotes RNA polymerase II (RNAPII hyperphosphorylation and subsequent changes in alternative splicing (AS. We show now that UV-induced DNA damage is not only necessary but sufficient to trigger the AS response and that photolyase-mediated removal of the most abundant class of pyrimidine dimers (PDs abrogates the global response to UV. We demonstrate that, in keratinocytes, RNAPII is the target, but not a sensor, of the signaling cascade initiated by PDs. The UV effect is enhanced by inhibition of gap-filling DNA synthesis, the last step in the nucleotide excision repair pathway (NER, and reduced by the absence of XPE, the main NER sensor of PDs. The mechanism involves activation of the protein kinase ATR that mediates the UV-induced RNAPII hyperphosphorylation. Our results define the sequence UV-PDs-NER-ATR-RNAPII-AS as a pathway linking DNA damage repair to the control of both RNAPII phosphorylation and AS regulation.

  3. 17th International Conference on Petroleum Phase Behavior and Fouling

    DEFF Research Database (Denmark)

    von Solms, Nicolas; Yan, Wei; Andersen, Simon

    2017-01-01

    This special section of Energy & Fuels contains contributedpapers from the 17th International Conference on PetroleumPhase Behavior and Fouling (Petrophase 2016). Petrophase 2016 was organized by the Technical University of Denmark and Schlumberger and took place in Elsinore (Helsingør) Denmark...... from June 19th to 23rd at the Beach Hotel Marienlyst. Petrophase is an international conference aimed at researchers in industry and academia dedicated to the study of the properties and chemistry of petroleum fluids and their effect on producing, processing, and refining in the upstream, midstream......, and downstream industries. The conference started in 1999 as “The International Conference on Petroleum Phase Behavior & Fouling” and has since evolved into an annual event taking place in countries all around the world. Petrophase has been fortunate to have enjoyed financial and organizational support from many...

  4. Aplicación de las espectroscopias IR/ATR y Raman al estudio de la superficie de vidrios sometidos a molturación

    Directory of Open Access Journals (Sweden)

    Pérez-Villar, S.

    2008-04-01

    Full Text Available The grinding process of vítreous silica and a conventional glass has been studied by means of Raman and IR/ATR spectroscopies. By using the obtained spectra, the positions and areas of the different bands have been calculated. The Raman spectra have been analysed using the Polymerisation Index (PI that indicates the depolymerization degree achieved on the particle surface after grinding. On the other hand, the IR/ATR spectra have been used to follow the positions of the symmetric and antisymmetric Si-O-Si bands. It has been observed that both techniques give similar results. These indicate that the depolymerisation degree increases with the grinding process. This depolymerisation is due to the broke of Si-O-Si bonds.

    El proceso de molienda de sílice vítrea y un vidrio convencional se ha estudiado mediante espectroscopias IR/ATR y Raman. A partir de los espectros obtenidos para diferentes tamaños de partícula se calcularon tanto las posiciones como las áreas de las bandas que aparecían en cada espectro. Utilizando los espectros Raman se ha hecho uso del denominado Índice de Polimerización (IP el cual es indicativo del grado de despolimerización producido en la superficie de las partículas tras el proceso de molienda. Por otro lado, mediante los espectros IR/ATR y analizando las posiciones de las bandas de tensión simétrica y asimétrica de los enlaces Si-O-Si se ha podido seguir el citado proceso de molturación. Se ha observado, mediante ambas técnicas, como la superficie de las partículas se despolimeriza al disminuir el tamaño de partícula. Esta despolimerización es debida a la rotura de los enlaces Si-O-Si.

  5. Tim Berners-Lee, World Wide Web inventor

    CERN Multimedia

    1998-01-01

    The "Internet, Web, What's next?" conference on 26 June 1998 at CERN: Tim Berners-Lee, inventor of the World Wide Web and Director of the W3C, explains how the Web came to be and gave his views on the future.

  6. Proceedings of the International Conference Nuclear Energy for New Europe 2006

    International Nuclear Information System (INIS)

    Glumac, B.; Lengar, I.

    2006-01-01

    International Conference Nuclear Energy for New Europe is an annual meeting of the Nuclear Society of Slovenia. The conference is meant to address the prospects and the future of the nuclear energy in the world faced with the, now already very expressed, threat of the global warming. The conference evolved from annual conferences of Nuclear Society of Slovenia, which was first held in the alpine resort Bovec in 1992. The jubilee 15th conference was held and it was attended by 138 participants from 20 countries. Topics are: next generation reactor and fuels, reactor physics, reactor operation, nuclear materials, nuclear fusion and plasma technology, thermal hydraulics, probabilistic safety assessment, severe accidents, radiology and environment, radioactive waste and education, public relations and regulatory issues.The technical part of the program was complemented with a visit to Institute Jozef Stefan TRIGA reactor which in 2006 celebrated forty years of operation

  7. Proceedings of the CERI 2004 Oil Conference : Insecurity of supply? CD-ROM ed.

    International Nuclear Information System (INIS)

    2004-01-01

    The 21 presentations at this conference reflected recent developments in the international petroleum industry with particular focus on the outlook of world energy markets and prospects for oil supply and reserves. Topics of discussion included an outlook for world oil prices, geopolitical hotspots for oil exporting countries, and geopolitical warm spots for the former Soviet Union. The conference also featured a debate on oil supply, prices and markets for Canadian oil. The significant potential of the Western Canadian oil sands reserves was also discussed with reference to oil sands supply outlook and development issues. Several presentations reviewed environmental issues such as climate change and the responsible use of water. The conference also provided an opportunity for participants to discuss the role that non-conventional oil play will play in the current marketplace. Thirteen papers were indexed separately for inclusion in the database. tabs., figs

  8. Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway.

    Directory of Open Access Journals (Sweden)

    Peng Xu

    2017-03-01

    Full Text Available Human parvovirus B19 (B19V infection of primary human erythroid progenitor cells (EPCs arrests infected cells at both late S-phase and G2-phase, which contain 4N DNA. B19V infection induces a DNA damage response (DDR that facilitates viral DNA replication but is dispensable for cell cycle arrest at G2-phase; however, a putative C-terminal transactivation domain (TAD2 within NS1 is responsible for G2-phase arrest. To fully understand the mechanism underlying B19V NS1-induced G2-phase arrest, we established two doxycycline-inducible B19V-permissive UT7/Epo-S1 cell lines that express NS1 or NS1mTAD2, and examined the function of the TAD2 domain during G2-phase arrest. The results confirm that the NS1 TAD2 domain plays a pivotal role in NS1-induced G2-phase arrest. Mechanistically, NS1 transactivated cellular gene expression through the TAD2 domain, which was itself responsible for ATR (ataxia-telangiectasia mutated and Rad3-related activation. Activated ATR phosphorylated CDC25C at serine 216, which in turn inactivated the cyclin B/CDK1 complex without affecting nuclear import of the complex. Importantly, we found that the ATR-CHK1-CDC25C-CDK1 pathway was activated during B19V infection of EPCs, and that ATR activation played an important role in B19V infection-induced G2-phase arrest.

  9. Nuclear energy: a world of service to humanity. 27th annual conference of the Canadian Nuclear Society and 30th Canadian Nuclear Society/Canadian Nuclear Association student conference

    International Nuclear Information System (INIS)

    2006-01-01

    The 27th Annual conference of the Canadian Nuclear Society was held on June 11-14, 2006 in Toronto, Ontario, Canada. The conference gathered close to 400 scientists, engineers, technologists and students interested in all aspects and applications of energy from the atom. The central objective of this conference was to provide a forum for exchange of views on how this technical enterprise can best serve the needs of humanity, now and in the future. The plenary sessions addressed broad industrial and commercial developments in the field. Over eighty papers were presented in 15 technical sessions on the following topics: safety analysis; plant refurbishment; control room operation; nuclear chemistry and materials; advanced reactor design; plant operation; reactor physics; safety analysis; nuclear instrumentation; and, nuclear general topics. Embedded in the conference was the 30th student conference, sponsored by the Canadian Nuclear Society and the Canadian Nuclear Association. Over thirty-five papers were presented in five sessions on the following topics: corrosion processes; control systems / physics / modelling; and, chemistry / chemical engineering

  10. 5th International Conference on Jets, Wakes and Separated Flows

    CERN Document Server

    2016-01-01

    This volume collects various contributions from the 5th International Conference on Jets, Wakes and Separated Flows (ICJWSF2015) that took place in Stockholm during June 2015. Researchers from all around the world presented their latest results concerning fundamental and applied aspects of fluid dynamics. With its general character, the conference embraced many aspects of fluid dynamics, such as shear flows, multiphase flows and vortex flows, for instance. The structure of the present book reflects the variety of topics treated within the conference i.e. Jets, Wakes, Separated flows, Vehicle aerodynamics, Wall-bounded and confined flows, Noise, Turbomachinery flows, Multiphase and reacting flows, Vortex dynamics, Energy-related flows and a section dedicated to Numerical analyses.

  11. EDS'09: 13th International Conference on Elastic & Diffractive Scattering

    CERN Document Server

    CERN. Geneva

    2009-01-01

    The series of International Conferences on Elastic and Diffractive Scattering was founded in 1985 in the picturesque old French town of Blois, famous for its XIV - XVIIth century château, inside of which the first meeting took place. Since then, meetings have been organised every two years in different places of the world: New York (1987), Evanston (1989), Isola d'Elba (1991), Providence (1993), Blois (1995), Seoul (1997), Protvino (1999), Prague (2001), Helsinki (2003), Blois (2005) and Hamburg (2007). The conference will focus on the most recent experimental and theoretical results in particle physics with an emphasis on Quantum Chromodynamics (QCD). http://cern.ch/eds09/ The conference agenda is now full. No further contributions can be accepted.

  12. International conference to explore ways to improve radiological protection of patients

    International Nuclear Information System (INIS)

    2001-01-01

    The first international conference specifically focused on the radiological protection of patients will be held in Torremolinos (Malaga), Spain, next week, from 26 to 30 March 2001. The conference, formally titled, 'International Conference on the Radiological Protection of Patients in Diagnostic and Interventional Radiology, Nuclear Medicine and Radiotherapy', is being organized by the IAEA, hosted by the Government of Spain and co-sponsored by the European Commission, the Pan American Health Organization and the World Health Organization. Medical applications of ionizing radiation are accepted world-wide as essential tools for keeping or restoring human health. However, they also represent by far the largest man-made source of radiation exposure. The United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) estimates that diagnostic medical applications of radiation account for about 95% of the exposure to radiation from man-made sources of radiation and about 12% of total exposure, which includes the exposures received from natural sources. More than 900 participants from 80 countries are expected to attend the conference. They cover a broad spectrum of expertise, including radiologists, nuclear medicine specialists, radiation oncologists, medical physicists, technologists/radiographers, radiological protection officers, equipment manufacturers, experts who develop standards for radiological equipment, hospital administrators and public health officials and representatives of professional societies. In addition, a number of patients who have undergone radiation treatment will represent patients' interests and a patient will chair one of the round table debates. The conclusions of the Conference will be incorporated into the IAEA's programme of work in the field of radiation safety and will be reported to the IAEA General Conference at its next meeting in September 2001

  13. New frontiers for tomorrow`s world

    Energy Technology Data Exchange (ETDEWEB)

    Kassler, P [Shell International Petroleum Co. Ltd., London (United Kingdom)

    1994-12-31

    The conference paper deals with new frontiers and barricades in the global economic development and their influence on fuel consumption and energy source development. Topics discussed are incremental energy supply - new frontiers, world car population - new frontiers, OPEC crude production capacity vs call on OPEC, incremental world oil demand by region 1992-2000, oil resource cost curve, progress in seismic 1983-1991, Troll picture, cost reduction in renewables, sustained growth scenario, nuclear electricity capacity - France, OECD road transport fuels - barricades, and energy taxation. 18 figs.

  14. Strategical challenges for the Copenhagen conference

    International Nuclear Information System (INIS)

    Anon.

    2009-01-01

    A CARA team analyzed the impacts and challenges generated by the new climatic, energetic and food situation of our security: conflict of interests between the North and South countries, USA-China equation, the european Union, France specificities. This analyse points out the main challenges for the France and the European Union during the world conference on the climate in december 2009 at Copenhagen. (A.L.B.)

  15. UV-induced nuclear import of XPA is mediated by importin-α4 in an ATR-dependent manner.

    Directory of Open Access Journals (Sweden)

    Zhengke Li

    Full Text Available Xeroderma pigmentosum Group A (XPA is a crucial factor in mammalian nucleotide excision repair (NER and nuclear import of XPA from the cytoplasm for NER is regulated in cellular DNA damage responses in S-phase. In this study, experiments were carried out to determine the transport mechanisms that are responsible for the UV (ultraviolet-induced nuclear import of XPA. We found that, in addition to the nuclear localization signal (NLS of XPA, importin-α4 or/and importin-α7 are required for the XPA nuclear import. Further investigation indicated that, importin-α4 and importin-α7 directly interacted with XPA in cells. Interestingly, the binding of importin-α4 to XPA was dependent on UV-irradiation, while the binding of importin-α7 was not, suggesting a role for importin-α7 in nuclear translocation of XPA in the absence of DNA damage, perhaps with specificity to certain non-S-phases of the cell-cycle. Consistent with the previous report of a dependence of UV-induced XPA nuclear import on ataxia telangiectasia and Rad3-related protein (ATR in S-phase, knockdown of ATR reduced the amount of XPA interacting with importin-α4. In contrast, the GTPase XPA binding protein 1 (XAB1, previously proposed to be required for XPA nuclear import, showed no effect on the nuclear import of XPA in our siRNA knockdown analysis. In conclusion, our results suggest that upon DNA damage transport adaptor importin-α4 imports XPA into the nucleus in an ATR-dependent manner, while XAB1 has no role in this process. In addition, these findings reveal a potential new therapeutic target for the sensitization of cancer cells to chemotherapy.

  16. State Petroleum Enterprises in developing countries. [Conference highlights

    Energy Technology Data Exchange (ETDEWEB)

    Constantinou, C

    1978-10-01

    The growth in production and consumption of Petroleum in the developing countries has been accompanied by the establishment of State Petroleum Enterprises with the task of undertaking exploration, production, transportation, refining and marketing. Participants at a United Nations Conference exchanged experiences in the organization, management, and activities of State Petroleum Enterprises and reviewed co-operative arrangements among themselves. A central clearinghouse to aid technology transfer and training experience to less-developed countries was proposed. The conference also stressed that cooperation between state enterprises should be expanded in the future at both the bilateral and regional levels. It was felt that the conference provided an impressive demonstration of the growing role of State Petroleum Enterprises as effective instruments of national petroleum and economic development and emphasized the increasing role they must play in the world economy. 10 references. (SAC)

  17. 5th International Conference on Fuzzy and Neuro Computing

    CERN Document Server

    Panigrahi, Bijaya; Das, Swagatam; Suganthan, Ponnuthurai

    2015-01-01

    This proceedings bring together contributions from researchers from academia and industry to report the latest cutting edge research made in the areas of Fuzzy Computing, Neuro Computing and hybrid Neuro-Fuzzy Computing in the paradigm of Soft Computing. The FANCCO 2015 conference explored new application areas, design novel hybrid algorithms for solving different real world application problems. After a rigorous review of the 68 submissions from all over the world, the referees panel selected 27 papers to be presented at the Conference. The accepted papers have a good, balanced mix of theory and applications. The techniques ranged from fuzzy neural networks, decision trees, spiking neural networks, self organizing feature map, support vector regression, adaptive neuro fuzzy inference system, extreme learning machine, fuzzy multi criteria decision making, machine learning, web usage mining, Takagi-Sugeno Inference system, extended Kalman filter, Goedel type logic, fuzzy formal concept analysis, biclustering e...

  18. Education for Sustainable Development at the United Nations Conference on Sustainable Development (Rio+20)

    Science.gov (United States)

    Journal of Education for Sustainable Development, 2012

    2012-01-01

    The United Nations Conference on Sustainable Development (Rio+20) was held in Rio de Janeiro, Brazil, 20-22 June 2012, marking the twentieth anniversary of the United Nations Conference on Sustainable Development in Rio de Janeiro in 1992 and the tenth anniversary of the 2002 World Summit on Sustainable Development in Johannesburg. With more than…

  19. Proceedings of the CERI 2005 Oil Conference : What's next? CD-ROM ed.

    International Nuclear Information System (INIS)

    2005-01-01

    Recent developments in the international petroleum industry were discussed, including events unfolding in the world such as rising oil prices, world oil demand and booming oil markets. The changes reflect both fundamental and geopolitical issues such as OPEC's potential productive capacity. The presentations addressed whether these developments in the petroleum industry represent a structural shift in the market or if they are merely another cyclical movement. In addition to the outlook for world energy markets and prospects for oil supply and reserves, this conference included discussions about oil price differentials, markets for Canadian oil, geopolitical hotspots for exporting countries, enhanced recovery for conventional resources and an oil sands outlook. The role that non-conventional oil play will play in the current marketplace was also addressed. The conference featured 18 presentations, of which 6 have been indexed separately for inclusion in this database. tabs., figs

  20. 12th International Conference on Multiple Criteria Decision Making

    CERN Document Server

    Gal, Tomas

    1997-01-01

    The organizers of the 12th International Conference on Multiple Cri­ teria Decision Making (MCDM) held June 19-23, 1995 in Hagen received the second time the opportunity to prepare an international conference on MCDM in Germany; the first opportunity has been the 3rd International Conference on MCDM in Konigswinter, 1979. Quite a time ellapsed since then and therefore it might be interesting to compare some indicators of the development of the International Society on MCDM, which has been founded in Konigswinter. Stanley Zionts has been elected first president and all 44 participants of that Conference became founding members. Today our Society has over 1200 members and its own Journal (MCDM World Scan). In Hagen, 1996, we had 152 participants from 34 countries. It is interesting to mention that also other Groups established their organi­ zation, like the European Working Group on Multiple Criteria Decision Aid, the German Working Group on Decision Theory and Applications, the Multi­ Objective Programming ...

  1. Arecoline-induced phosphorylated p53 and p21(WAF1) protein expression is dependent on ATM/ATR and phosphatidylinositol-3-kinase in clone-9 cells.

    Science.gov (United States)

    Chou, Wen-Wen; Guh, Jinn-Yuh; Tsai, Jung-Fa; Hwang, Chi-Ching; Chiou, Shean-Jaw; Chuang, Lea-Yea

    2009-06-01

    Betel-quid use is associated with liver cancer whereas its constituent arecoline is cytotoxic, genotoxic, and induces p53-dependent p21(WAF1) protein expression in Clone-9 cells (rat hepatocytes). The ataxia telangiectasia mutated (ATM)/rad3-related (ATR)-p53-p21(WAF1) and the phosphatidylinositol-3-kinase (PI3K)-mammalian target of rapamycin (mTOR) pathways are involved in the DNA damage response and the pathogenesis of cancers. Thus, we studied the role of ATM/ATR and PI3K in arecoline-induced p53 and p21(WAF1) protein expression in Clone-9 cells. We found that arecoline (0.5 mM) activated the ATM/ATR kinase at 30 min. The arecoline-activated ATM/ATR substrate contained p-p53Ser15. Moreover, arecoline only increased the levels of the p-p53Ser6, p-p53Ser15, and p-p53Ser392 phosphorylated p53 isoforms among the known isoforms. ATM shRNA attenuated arecoline-induced p-p53Ser15 and p21(WAF1) at 24 h. Arecoline (0.5 mM) increased phosphorylation levels of p-AktSer473 and p-mTORSer2448 at 30-60 min. Dominant-negative PI3K plasmids attenuated arecoline-induced p21(WAF1), but not p-p53Ser15, at 24 h. Rapamycin attenuated arecoline-induced phosphrylated p-p53Ser15, but not p21(WAF1), at 24 h. ATM shRNA, but not dominant-negative PI3K plasmids, attenuated arecoline-induced p21(WAF1) gene transcription. We conclude that arecoline activates the ATM/ATR-p53-p21(WAF1) and the PI3K/Akt-mTOR-p53 pathways in Clone-9 cells. Arecoline-induced phosphorylated p-p53Ser15 expression is dependent on ATM whereas arecoline-induced p21(WAF1) protein expression is dependent on ATM and PI3K. Moreover, p21(WAF1) gene is transcriptionally induced by arecoline-activated ATM. (c) 2009 Wiley-Liss, Inc.

  2. An ATR-dependent function for the Ddx19 RNA helicase in nuclear R-loop metabolism.

    Science.gov (United States)

    Hodroj, Dana; Recolin, Bénédicte; Serhal, Kamar; Martinez, Susan; Tsanov, Nikolay; Abou Merhi, Raghida; Maiorano, Domenico

    2017-05-02

    Coordination between transcription and replication is crucial in the maintenance of genome integrity. Disturbance of these processes leads to accumulation of aberrant DNA:RNA hybrids (R-loops) that, if unresolved, generate DNA damage and genomic instability. Here we report a novel, unexpected role for the nucleopore-associated mRNA export factor Ddx19 in removing nuclear R-loops formed upon replication stress or DNA damage. We show, in live cells, that Ddx19 transiently relocalizes from the nucleopore to the nucleus upon DNA damage, in an ATR/Chk1-dependent manner, and that Ddx19 nuclear relocalization is required to clear R-loops. Ddx19 depletion induces R-loop accumulation, proliferation-dependent DNA damage and defects in replication fork progression. Further, we show that Ddx19 resolves R-loops in vitro via its helicase activity. Furthermore, mutation of a residue phosphorylated by Chk1 in Ddx19 disrupts its interaction with Nup214 and allows its nuclear relocalization. Finally, we show that Ddx19 operates in resolving R-loops independently of the RNA helicase senataxin. Altogether these observations put forward a novel, ATR-dependent function for Ddx19 in R-loop metabolism to preserve genome integrity in mammalian cells. © 2017 The Authors.

  3. Measured thermal and fast neutron fluence rates, ATR Cycle 102-A, 11/28/93 thru 1/16/94

    International Nuclear Information System (INIS)

    Murray, R.K.; Rogers, J.W.

    1994-02-01

    This report contains the thermal (2,200 m/s) and fast (E > 1MeV) neutron fluence rate data for ATR Cycle 102-A which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains fluence rate values corresponding to the particular elevations (relative to the 80 ft. core elevation) where the measurements were taken. The data in this report consists of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, (3) plots of both the thermal and fast neutron fluence rates, and (4) a magnetic record (3.5 inch diskette) containing a listing of only the fast neutron fluence rates, their assigned elevations and proper header identification of all monitor positions contained herein. The fluence rates reported are for the average power levels given in the table of power history and distribution. All ''H'' holder monitoring wires for this cycle are 54 inches long. All ''SR'' holder monitor wires for this cycle are 55 inches long. This length allows measurement of the full core region and makes the first count elevation 24.73 inches above core midplane. Due to the safety rod problems in the west lobe, ''BR'' holders were used in the W-1, 2, 3, and 4 positions. All ''BR'' holder monitor wires for this cycle are 56.25 inches long. The distance from the end of the wires to the first count position was 4.25 inches for all wires counted from this cycle

  4. The application of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the stratum corneum.

    Science.gov (United States)

    Goh, Choon Fu; Craig, Duncan Q M; Hadgraft, Jonathan; Lane, Majella E

    2017-02-01

    Drug permeation through the intercellular lipids, which pack around and between corneocytes, may be enhanced by increasing the thermodynamic activity of the active in a formulation. However, this may also result in unwanted drug crystallisation on and in the skin. In this work, we explore the combination of ATR-FTIR spectroscopy and multivariate data analysis to study drug crystallisation in the skin. Ex vivo permeation studies of saturated solutions of diclofenac sodium (DF Na) in two vehicles, propylene glycol (PG) and dimethyl sulphoxide (DMSO), were carried out in porcine ear skin. Tape stripping and ATR-FTIR spectroscopy were conducted simultaneously to collect spectral data as a function of skin depth. Multivariate data analysis was applied to visualise and categorise the spectral data in the region of interest (1700-1500cm -1 ) containing the carboxylate (COO - ) asymmetric stretching vibrations of DF Na. Spectral data showed the redshifts of the COO - asymmetric stretching vibrations for DF Na in the solution compared with solid drug. Similar shifts were evident following application of saturated solutions of DF Na to porcine skin samples. Multivariate data analysis categorised the spectral data based on the spectral differences and drug crystallisation was found to be confined to the upper layers of the skin. This proof-of-concept study highlights the utility of ATR-FTIR spectroscopy in combination with multivariate data analysis as a simple and rapid approach in the investigation of drug deposition in the skin. The approach described here will be extended to the study of other actives for topical application to the skin. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. EPAC impact (European Particle Accelerator Conference report)

    International Nuclear Information System (INIS)

    Clarke, Jim

    1994-01-01

    Acurtain rose on the current world accelerator stage at the end of June when almost 750 delegates gathered in London for the fourth biennial European Particle Accelerator Conference (EPAC). As well as reports from all major Laboratories on their latest accelerator achievements and future plans, a special session featured invited contributions on high intensity issues while a seminar covered the increasing transfer of technology between Accelerator Laboratories and Industry. The first invited talk of the conference, by CERN Director General Chris Llewellyn Smith, concerned the future of high energy physics in Europe. Naturally this focused on the Large Hadron Collider project at CERN, which will open up important new physics frontiers for the 21st century

  6. 11th Portuguese Conference on Automatic Control

    CERN Document Server

    Matos, Aníbal; Veiga, Germano

    2015-01-01

    During the last 20 years the Portuguese association of automatic control, Associação Portuguesa de Controlo Automático, with the sponsorship of IFAC have established the CONTROLO conference as a reference international forum where an effective exchange of knowledge and experience amongst researchers active in various theoretical and applied areas of systems and control can take place, always including considerable space for promoting new technical applications and developments, real-world challenges and success stories. In this 11th edition the CONTROLO conference evolved by introducing two strategic partnerships with Spanish and Brazilian associations in automatic control, Comité Español de Automática and Sociedade Brasileira de Automatica, respectively.

  7. PREFACE: 12th Europhysical Conference on Defects in Insulating Materials (EURODIM 2014)

    Science.gov (United States)

    Alfredsson, M. L.; Chadwick, A. V.; Jackson, R. A.; McCabe, E. E.

    2015-04-01

    The 12th Europhysical Conference on Defects in Insulating Materials (EURODIM14) was held at the University of Kent, UK, from 13-18 July 2014. It was attended by about 120 delegates from around the world, and featured 56 oral presentations and 77 posters. EURODIM14 followed other conferences in the series, held in Pecs (2010), Milan (2006) and Wroclaw (2002), as well as the related ICDIM conferences held in Santa Fe (2012), Aracaju (2008) and Riga (2004). These conferences all have the aim of bringing together scientists to discuss the chemistry and physics of defects in solids, and their role in determining material properties. We would like to thank the International Advisory Committee for suggesting invited speakers, and the Local and Programme Committee for their hard work in planning and running the conference. Finally we would like to thank the authors and referees for their contributions to the proceedings. M L Alfredsson (Conference Chair) A V Chadwick R A Jackson E E McCabe

  8. The World Anti-Doping Agency and the challenges for political steering

    DEFF Research Database (Denmark)

    Wagner, Ulrik

    2008-01-01

    Article submitted March 2007 for the Graduate Paper Award of the International Sociology of Sport Association. Presented as winner at "Sport in a Global World - past, present, future" the first joint world conference of ISSA & ISHPES at the University of Copenhagen, July 31st - August 5th 2007....

  9. Toward an African-Christian Demonology: The Demonologies of African Traditional Religion, African Christianity, and Early Christianity in Dialogue

    Directory of Open Access Journals (Sweden)

    Moscicke, Hans

    2017-11-01

    Full Text Available Christian interactions with the spirit-world of African traditional religion (ATR have remained problematic due, in part, to the failure of Christian missionaries to understand in detail the cosmology of ATR and the angelologies and demonologies of early Christianity. In this article I suggest a way beyond this impasse. I first survey the shape of cosmology and demonology in ATR, and then examine African Christianitys variegated responses to these traditional beliefs. Finally, I submit that a retrieval of the early Christian mythological narrative about demons and its associated cosmology could help theologians accommodate the spirit-world of ATR within a truly African-Christian theology.

  10. EPRI-DOE Conference on Environmentally-Enhanced Hydropower Turbines: Technical Papers

    Energy Technology Data Exchange (ETDEWEB)

    Hogan, T. [Alden Research Laboratory, Inc., Holden, MA (United States)

    2011-12-01

    The EPRI-DOE Conference on Environmentally-Enhanced Hydropower Turbines was a component of a larger project. The goal of the overall project was to conduct the final developmental engineering required to advance the commercialization of the Alden turbine. As part of this effort, the conference provided a venue to disseminate information on the status of the Alden turbine technology as well as the status of other advanced turbines and research on environmentally-friendly hydropower turbines. The conference was also a product of a federal Memorandum of Understanding among DOE, USBR, and USACE to share technical information on hydropower. The conference was held in Washington, DC on May 19 and 20, 2011 and welcomed over 100 attendees. The Conference Organizing Committee included the federal agencies with a vested interest in hydropower in the U.S. The Committee collaboratively assembled this conference, including topics from each facet of the environmentally-friendly conventional hydropower research community. The conference was successful in illustrating the readiness of environmentally-enhanced hydropower technologies. Furthermore, the topics presented illustrated the need for additional deployment and field testing of these technologies in an effort to promote the growth of environmentally sustainable hydropower in the U.S. and around the world.

  11. Proteomics Reveals Global Regulation of Protein SUMOylation by ATM and ATR Kinases during Replication Stress

    DEFF Research Database (Denmark)

    Munk, Stephanie; Sigurðsson, Jón Otti; Xiao, Zhenyu

    2017-01-01

    The mechanisms that protect eukaryotic DNA during the cumbersome task of replication depend on the precise coordination of several post-translational modification (PTM)-based signaling networks. Phosphorylation is a well-known regulator of the replication stress response, and recently an essentia....... They analyze changes in the SUMO and phosphoproteome after MMC and hydroxyurea treatments and find that the DNA damage response kinases ATR and ATM globally regulate SUMOylation upon replication stress and fork breakage....

  12. The Second Joint NASA/FAA/DoD Conference on Aging Aircraft. Part 2

    Science.gov (United States)

    Harris, Charles E. (Editor)

    1999-01-01

    The purpose of the Conference was to bring together world leaders in aviation safety research, aircraft design and manufacturing, fleet operation and aviation maintenance to disseminate information on current practices and advanced technologies that will assure the continued airworthiness of the aging aircraft in the military and commercial fleets. The Conference included reviews of current industry practices, assessments of future technology requirements, and status of aviation safety research. The Conference provided an opportunity for interactions among the key personnel in the research and technology development community, the original equipment manufacturers, commercial airline operators, military fleet operators, aviation maintenance, and aircraft certification and regulatory authorities. Conference participation was unrestricted and open to the international aviation community. Appendix B contains the name and addresses of the 623 participants in the Conference.

  13. Intelligence and Schooling. Fueling the Education Explosion: Proceedings of Conference 2 (Cleveland, Ohio, November 17-18, 1983).

    Science.gov (United States)

    Gardner, Mary, Ed.; Reed-Mundell, Charlene, Ed.

    These proceedings contain presentations from a conference whose major topics were real-world intelligence, artificial intelligence, and linkage between the education and corporate sectors. "People, Perspectives...Potential and Possibilities" (Elyse S. Fleming), which was the conference's closing speech, briefly summarizes the information…

  14. PREFACE: Asia-Pacific Interdisciplinary Research Conference 2011 (AP-IRC 2011)

    Science.gov (United States)

    Sandhu, Adarsh; Okada, Hiroshi; Maekawa, Toru; Okano, Ken

    2012-03-01

    AP-IRC Logo Scientists, engineers, entrepreneurs and policymakers gather at the first truly interdisciplinary conference held in Asia-Pacific http://www.apirc.jp/ The inaugural Asia-Pacific Interdisciplinary Research Conference 2011 (AP-IRC 2011) was held at Toyohashi University of Technology (Toyohashi Tech) on 17-18 November 2011. The conference is a forum for enhancing mutual understanding between scientists, engineers, policymakers and experts from a wide spectrum of pure and applied sciences, to resolve the daunting global issues facing mankind. The conference attracted approximately 300 participants including delegates from France, Germany, India, Indonesia, Korea, Malaysia, Russia, Sweden, United Kingdom, USA and Vietnam. AP-IRC 2011 was chaired by Dr Yoshiyuki Sakaki, President of Toyohashi Tech, who opened the proceedings by stressing the importance of an interdisciplinary approach to research, to resolve global scientific and technical issues. Recalling his own experience as the leader of Japan's efforts in the Human Genome Project, Sakaki also encouraged participants to make an effort to try to understand the sometimes difficult concepts and terminology of other areas of research. The presentations at AP-IRC 2011 were divided into three focus sessions: innovative mechano-magneto-electronic systems, life sciences, and green science and technology. A total of 174 papers were presented over the two-day conference including eight by invited speakers. Highlights of AP-IRC 2011 included a first-hand account of the damage caused by the massive earthquake in March 2011 to experimental facilities at Tohoku University by Masayoshi Esashi; the fascinating world of bees and the inborn numerical competence of humans and animals by Hans J Gross; research on robots and cognition-enabled technical systems at Technische Universität München by Sandra Hirche; the history of events leading to the invention of the world's strongest NdFeB permanent magnet by Masato Sagawa

  15. Advancing nuclear technology and research. The advanced test reactor national scientific user facility

    Energy Technology Data Exchange (ETDEWEB)

    Benson, Jeff B; Marshall, Frances M [Idaho National Laboratory, Idaho Falls, ID (United States); Allen, Todd R [Univ. of Wisconsin, Madison, WI (United States)

    2012-03-15

    The Advanced Test Reactor (ATR), at the Idaho National Laboratory (INL), is one of the world's premier test reactors for providing the capability for studying the effects of intense neutron and gamma radiation on reactor materials and fuels. The INL also has several hot cells and other laboratories in which irradiated material can be examined to study material radiation effects. In 2007 the US Department of Energy (DOE) designated the ATR as a National Scientific User Facility (NSUF) to facilitate greater access to the ATR and the associated INL laboratories for material testing research. The mission of the ATR NSUF is to provide access to world-class facilities, thereby facilitating the advancement of nuclear science and technology. Cost free access to the ATR, INL post irradiation examination facilities, and partner facilities is granted based on technical merit to U.S. university-led experiment teams conducting non-proprietary research. Proposals are selected via independent technical peer review and relevance to United States Department of Energy. To increase overall research capability, ATR NSUF seeks to form strategic partnerships with university facilities that add significant nuclear research capability to the ATR NSUF and are accessible to all ATR NSUF users. (author)

  16. World Council of Nuclear Workers (WONUC). Report of the 1st international Conference

    International Nuclear Information System (INIS)

    Domel, R.

    1999-08-01

    This, the first conference organised by WONUC, attracted papers dealing with many aspects of low and very low doses of ionising radiation, including molecular and genetic aspects and epidemiological studies. There was a lively debate on the 'linear no threshold' model and on whether Hiroshima/Nagasaki data should still be used to determine dose limits for workers and the general public. The conference highlighted the growing scientific understanding and debate of effects of low and very low doses of ionising radiation and it is important that workers in Australia should have first-hand access to this information. Indeed, if in years to come radiation hormesis is demonstrated, workers should be made aware of that possibility and the fact that their place of employment may hold an additional health benefit rather than a reputed health risk. I believe that such a positive attitudinal shift would certainly help nuclear workers to counter the ever-present negative sentiments of the anti-nuclear lobby groups

  17. Proceedings of the CERI 2004 petrochemical conference : Positioning for recovery. CD-ROM ed.

    International Nuclear Information System (INIS)

    2004-01-01

    This conference provided a networking opportunity for those involved in Canada's petrochemical industry. The conditions that affect the industry were discussed along with opportunities for maintaining a competitive position in a global context. Topics of discussion included supply shortages, high costs and major shifts in international trade. It was emphasized that innovation is the key for the industry to maintain its market in a strengthening world economy. The conference featured the following 6 sessions: (1) petrochemicals in a strengthening world economy, (2) twenty-first century natural gas, the other energy crisis, (3) electricity, (4) the feedstock future, upgrading and integration opportunities, (5) adding value to resources, and (6) innovation and opportunity, prospects for new processes. Investment growth and implications for Canada were also outlined along with the challenge of product movement, including new approaches to pipeline shipments, rail transport and maritime transport. The conference featured 23 presentations, of which 9 have been indexed separately for inclusion in this database. tabs., figs

  18. A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions

    Science.gov (United States)

    Shimizu, Kiminori; Paul, Sanjoy; Ohba, Ayumi; Gonoi, Tohru; Watanabe, Akira; Gomi, Katsuya

    2017-01-01

    Successful treatment of aspergillosis caused by Aspergillus fumigatus is threatened by an increasing incidence of drug resistance. This situation is further complicated by the finding that strains resistant to azoles, the major antifungal drugs for aspergillosis, have been widely disseminated across the globe. To elucidate mechanisms underlying azole resistance, we identified a novel transcription factor that is required for normal azole resistance in Aspergillus fungi including A. fumigatus, Aspergillus oryzae, and Aspergillus nidulans. This fungal-specific Zn2-Cys6 type transcription factor AtrR was found to regulate expression of the genes related to ergosterol biosynthesis, including cyp51A that encodes a target protein of azoles. The atrR deletion mutant showed impaired growth under hypoxic conditions and attenuation of virulence in murine infection model for aspergillosis. These results were similar to the phenotypes for a mutant strain lacking SrbA that is also a direct regulator for the cyp51A gene. Notably, AtrR was responsible for the expression of cdr1B that encodes an ABC transporter related to azole resistance, whereas SrbA was not involved in the regulation. Chromatin immunoprecipitation assays indicated that AtrR directly bound both the cyp51A and cdr1B promoters. In the clinically isolated itraconazole resistant strain that harbors a mutant Cyp51A (G54E), deletion of the atrR gene resulted in a hypersensitivity to the azole drugs. Together, our results revealed that AtrR plays a pivotal role in a novel azole resistance mechanism by co-regulating the drug target (Cyp51A) and putative drug efflux pump (Cdr1B). PMID:28052140

  19. Information and Communication Technologies Innovations conference

    CERN Document Server

    Kocarev, Ljupco

    2012-01-01

    Information and Communication Technologies has enlarged its horizon and it is practiced under multidisciplinary contexts that introduce new challenges to theoretical and technical approaches. The most critical benefit of introducing new ICT technologies in our real world living are the new ways of working that the online world makes possible. Complexity, uncertainty and scaling issues of real world problems as well as natural phenomena in ecology, medicine and biology demanding ICT assistance create challenging application domains for artificial intelligence, decision support and intelligence systems, wireless sensor networks, pervasive and ubiquitous computing, multimedia information systems, data management systems, internet and web applications and services, computer networks, security and cryptography, distributed systems, GRID and cloud computing. This book offers a collection of papers presented at the Third International Conference on ICT Innovations held in September 2011, in Skopje, Macedonia. The co...

  20. First energy conference Israel-former USSR

    International Nuclear Information System (INIS)

    Zamkov, S.

    1993-01-01

    The most significant deliberations of the conference dealt with the energy issues confronting the participating countries and the world as a whole: solution to current energy problems and the replacement of finite energy sources with renewable and clean resources. It is relevant to mention here the impressive presentation on the prospect of nuclear power in the former USSR following the Chernobyl accident, summarizing the perceptions on this critical issue

  1. Lift-off for World Year of Physics

    CERN Multimedia

    2005-01-01

    Over 1000 participants, including eight Nobel Prize Laureates, personalities from the world of science and close to 500 students from 70 countries took part in the "Physics for Tomorrow" conference at UNESCO headquarters in Paris on 13 January 2005. The event marked the official launch of the International Year of Physics, proclaimed by the United Nations. The International Year aims to highlight the importance of physics and its contribution to the development of many other scientific disciplines. It is also to help fight the current lack of enthusiasm for sciences among young people. Throughout 2005, events will be organized across the world to debate physics and it implications to society. The conference was organized by UNESCO, the lead UN organization for the International Year, and by the physics community, in particular by CERN, CNRS and CEA, EU Commission, EPS, IUPAP and others. CERN Director-General, Robert Aymar, participating to the Inauguration Session of the Launch Event of the International Y...

  2. What Prospects for the World Trading System?

    Directory of Open Access Journals (Sweden)

    Agnes Ghibuțiu

    2014-07-01

    Full Text Available New developments and dramatic changes are under way in the world trading system. This paper aims to take stock of the latest and most relevant developments and highlight the prospects for global trade governance. The focus is on three major issues, i.e. : (1 the outcome of the Ninth WTO Ministerial Conference in December 2013 in Bali (Indonesia and especially its significance for enhancing the multilateral trading system; (2 the accelerated pace and scale of negotiations on regional trade agreements (RTAs and their wider impact; and (3 the positive results of continued unilateral trade liberalization efforts, in contrast with the pervasiveness of crisis-related protectionist measures. The paper concludes that, despite improved prospects for multilateral trade liberalization following the last WTO Ministerial Conference, the world trading system is becoming more fragmented and less coherent, and also more uncertain, being increasingly driven by RTAs and a variable geometry approach to WTO trade agreements.

  3. World renewable energy and environmental conference: abstract book

    International Nuclear Information System (INIS)

    2006-01-01

    The energy is a wrap of the life and the main source of it is sources. The protection continuity of the energy is important cause of the scientific research development which we observe it on our energy every day life. But instead of the importance of the oil a main energy source which all the world depend on, there are many notes from the scientist, researchers and the environment institutions about the risks of the dependence on the traditional energy sources, and stressed on the study of it is negative effect on the environment human life and global community, also the call for looking for another substitutions about more safe sources and suitable for the environment. This comes on the interest frame which the university of Sebha and Libya in general gives it is special concern and reflect it is care of the scientific research and technical development to ascent our higher education institutions level in Libya, and it is contribution in the investigation and study of scientific issues which serve the aims of the society and it is anticipation and to be a good event for the meeting between the specialists and researchers from all over the world. (author)

  4. 19th European Conference on Mathematics for Industry

    CERN Document Server

    Barral, Patricia; Gómez, Dolores; Pena, Francisco; Rodríguez, Jerónimo; Salgado, Pilar; Vázquez-Méndez, Miguel; ECMI 2016; Progress in industrial mathematics

    2017-01-01

    This book addresses mathematics in a wide variety of applications, ranging from problems in electronics, energy and the environment, to mechanics and mechatronics. Using the classification system defined in the EU Framework Programme for Research and Innovation H2020, several of the topics covered belong to the challenge climate action, environment, resource efficiency and raw materials; and some to health, demographic change and wellbeing; while others belong to Europe in a changing world – inclusive, innovative and reflective societies. The 19th European Conference on Mathematics for Industry, ECMI2016, was held in Santiago de Compostela, Spain in June 2016. The proceedings of this conference include the plenary lectures, ECMI awards and special lectures, mini-symposia (including the description of each mini-symposium) and contributed talks. The ECMI conferences are organized by the European Consortium for Mathematics in Industry with the aim of promoting interaction between academy and industry, leading...

  5. 18th European Conference on Mathematics for Industry

    CERN Document Server

    Capasso, Vincenzo; Nicosia, Giuseppe; Romano, Vittorio

    2016-01-01

    This book presents a collection of papers emphasizing applications of mathematical models and methods to real-world problems of relevance for industry, life science, environment, finance, and so on. The biannual Conference of ECMI (the European Consortium of Mathematics in Industry) held in 2014 focused on various aspects of industrial and applied mathematics. The five main topics addressed at the conference were mathematical models in life science, material science and semiconductors, mathematical methods in the environment, design automation and industrial applications, and computational finance. Several other topics have been treated, such as, among others, optimization and inverse problems, education, numerical methods for stiff pdes, model reduction, imaging processing, multi physics simulation, mathematical models in textile industry. The conference, which brought together applied mathematicians and experts from industry, provided a unique opportunity to exchange ideas, problems and methodologies...

  6. Protistology Conferences: The Beginnings. The First International Protozoology Conference (Prague 1961) and the Tribute to Otto Jírovec, its Spiritual Father.

    Science.gov (United States)

    Vávra, Jiří

    2018-01-27

    Two events have helped to shape protozoology/protistology as a specific scientific discipline. The first such event was the creation of the Society of Protozoologists in the U.S. in 1947 (and of its Journal of Protozoology, first published in 1954), the second event was the First International Conference on Protozoology, held in 1961 in Prague. The history of the Society of Protozoologists was comprehensively treated by Corliss (1998); the history of the Prague Conference is presented here as reminiscences and personal interpretation of events of the author, who was one of the conference organizers and a member of the organization committee. Special attention is given to the personality and scientific accomplishments of Otto Jírovec, the 1961 conference spiritual father and president. It is concluded that the Prague Conference, while establishing the tradition of protistology meetings, helped protistology to attain its present status as a fundamental science discipline, which discovers and interprets the web of life at one of its, basic, "microbial" levels. Protists literally permeate the earth biosphere and in a way represent the "dark matter" of the living world, still awaiting many discoveries. © 2018 The Author(s) Journal of Eukaryotic Microbiology © 2018 International Society of Protistologists.

  7. American Mock World Health Organization: An Innovative Model for Student Engagement in Global Health Policy

    Science.gov (United States)

    Lei, Mia; Acharya, Neha; Kwok Man Lee, Edith; Catherine Holcomb, Emma; Kapoor, Veronica

    2017-01-01

    ABSTRACT The American Mock World Health Organization (AMWHO) is a model for experiential-based learning and student engagement in global health diplomacy. AMWHO was established in 2014 at the University of North Carolina at Chapel Hill with a mission to engage students in health policy by providing a simulation of the World Health Assembly (WHA), the policy-forming body of the World Health Organization that sets norms and transforms the global health agenda. AMWHO conferences are designed to allow students to take their knowledge of global health beyond the classroom and practice their skills in diplomacy by assuming the role of WHA delegates throughout a 3-day weekend. Through the process of developing resolutions like those formed in the WHA, students have the unique opportunity to understand the complexities behind the conflict and compromise that ensues through the lens of a stakeholder. This article describes the structure of the first 2 AMWHO international conferences, analyzes survey results from attendees, and discusses the expansion of the organization into a multi-campus national network. The AMWHO 2014 and 2015 post-conference survey results found that 98% and 90% of participants considered the conference "good" or "better," respectively, and survey responses showed that participants considered the conference "influential" in their careers and indicated that it "allowed a paradigm shift not possible in class." PMID:28351883

  8. 8th international conference on electronic spectroscopy and structure

    Energy Technology Data Exchange (ETDEWEB)

    Robinson, Art

    2000-10-16

    Gathering from 33 countries around the world, 408 registrants and a number of local drop-in participants descended on the Clark Kerr Campus of the University of California, Berkeley, from Monday, August 7 through Saturday, August 12, 2000 for the Eighth International Conference on Electronic Structure and Spectroscopy (ICESS8). At the conference, participants benefited from an extensive scientific program comprising more than 100 oral presentations (plenary lectures and invited and contributed talks) and 330 poster presentations, as well as ample time for socializing and a tour of the Advanced Light Source (ALS) at the nearby Lawrence Berkeley National Laboratory.

  9. CERN announces major conference on the information society

    CERN Multimedia

    2003-01-01

    "A side event to the World Summit on the Information Society (Geneva, December 2003) will explore the past and future contributions of science to the information society. Hosted by CERN , the Role of Science in the Information Society (RSIS) conference will bring together scientists and representatives of funding agencies and governments worldwide" (1 page).

  10. Trasmission and Reflection (ATR)Far-Infrared Spectroscopy Applied in the Analysis of Cultural Heritage Materials

    OpenAIRE

    Kendix, Elsebeth Langholz

    2009-01-01

    FIR spectroscopy is an alternative way of collecting spectra of many inorganic pigments and corrosion products found on art objects, which is not normally observed in the MIR region. Most FIR spectra are traditionally collected in transmission mode but as a real novelty it is now also possible to record FIR spectra in ATR (Attenuated Total Reflectance) mode. In FIR transmission we employ polyethylene (PE) for preparation of pellets by embedding the sample in PE. Unfortunately, ...

  11. A Feasibility Study to Determine Cooling Time and Burnup of ATR Fuel Using a Nondestructive Technique and Three Types of Gamma-ray Detectors

    International Nuclear Information System (INIS)

    Navarro, Jorge; Aryaeinejad, Rahmat; Nigg, David W.

    2011-01-01

    Effective and efficient Advanced Test Reactor (ATR) fuel management require state of the art core modeling tools. These new tools will need isotopic and burnup validation data before they are put into production. To create isotopic, burn up validation libraries and to determine the setup for permanent fuel scanner system a feasibility study was perform. The study consisted in measuring short and long cooling time fuel elements at the ATR canal. Three gamma spectroscopy detectors (HPGe, LaBr3, and HPXe) and two system configurations (above and under water) were used in the feasibility study. The first stage of the study was to investigate which detector and system configuration would be better suited for different scenarios. The second stage of the feasibility study was to create burnup and cooling time calibrations using experimental isotopic data collected and ORIGEN 2.2 burnup data. The results of the study establish that a better spectra resolution is achieve with an above the water configuration and that three detectors can be used in the permanent fuel scanner system for different situations. In addition it was conclude that a number of isotopic ratios and absolute measurements could be used to predict ATR fuel burnup and cooling times.

  12. Quantitative analysis of glycated albumin in serum based on ATR-FTIR spectrum combined with SiPLS and SVM.

    Science.gov (United States)

    Li, Yuanpeng; Li, Fucui; Yang, Xinhao; Guo, Liu; Huang, Furong; Chen, Zhenqiang; Chen, Xingdan; Zheng, Shifu

    2018-08-05

    A rapid quantitative analysis model for determining the glycated albumin (GA) content based on Attenuated total reflectance (ATR)-Fourier transform infrared spectroscopy (FTIR) combining with linear SiPLS and nonlinear SVM has been developed. Firstly, the real GA content in human serum was determined by GA enzymatic method, meanwhile, the ATR-FTIR spectra of serum samples from the population of health examination were obtained. The spectral data of the whole spectra mid-infrared region (4000-600 cm -1 ) and GA's characteristic region (1800-800 cm -1 ) were used as the research object of quantitative analysis. Secondly, several preprocessing steps including first derivative, second derivative, variable standardization and spectral normalization, were performed. Lastly, quantitative analysis regression models were established by using SiPLS and SVM respectively. The SiPLS modeling results are as follows: root mean square error of cross validation (RMSECV T ) = 0.523 g/L, calibration coefficient (R C ) = 0.937, Root Mean Square Error of Prediction (RMSEP T ) = 0.787 g/L, and prediction coefficient (R P ) = 0.938. The SVM modeling results are as follows: RMSECV T  = 0.0048 g/L, R C  = 0.998, RMSEP T  = 0.442 g/L, and R p  = 0.916. The results indicated that the model performance was improved significantly after preprocessing and optimization of characteristic regions. While modeling performance of nonlinear SVM was considerably better than that of linear SiPLS. Hence, the quantitative analysis model for GA in human serum based on ATR-FTIR combined with SiPLS and SVM is effective. And it does not need sample preprocessing while being characterized by simple operations and high time efficiency, providing a rapid and accurate method for GA content determination. Copyright © 2018 Elsevier B.V. All rights reserved.

  13. International Conference on water reuse and desalination

    International Nuclear Information System (INIS)

    1984-01-01

    The International conference on water reuse and desalination was held on the 13 November 1984 in Johannesburg, South Africa. Papers delivered on this conference covered the following aspects: desalination technology, industrial effluent control, economics of desalination of wastewaters, consumable supplies in desalination, the world market for seawater desalination equipment, reverse osmosis, evaporation and ultrafiltration, treatment of hazardous wastes, role of reverse osmosis in waste water treatment, as well as the desalination, recovery and recycle of water with high efficiency. A paper was also delivered on the mechanical vapour compression process applied to seawater desalination - as an example the paper presents the largest unit so far constructed by SIDEM using this process: a 1,500 mz/day unit installed in the Nuclear power plant of Flamanville in France

  14. First UN member state conference on the climate framework convention

    International Nuclear Information System (INIS)

    Lamprecht, F.

    1995-01-01

    The ''Framework Convention of the United Nations Concerning Climate Changes'' (Climate Framework Convention - KRK), which was passed at the 1992 World Environment Conference (UNCEO) in Rio de Janeiro and took effect on 21 March 1994, has instituted the UN Conference of Contracting Parties (VSK) as the organ presiding over this issue (Article 7 KRK). This annual conference has the task to implement the KRK and its associated legal instruments and pass the resolutions required to this end. Its premiere took place in Berlin (28 March to 7 April 1995). Delegates from 117 signatory and 53 observer states struggled before an audience of 2000 news reportes to find a solution to the pending tasks that might be tolerable for all participants. The present article gives a brief outline of these tasks and the results achieved in Berlin. The picture is rounded off by information on the different positions defended, lines of conflict and the course of the conference. (orig.) [de

  15. Vancouver Cyclotron Conference

    International Nuclear Information System (INIS)

    Clark, David J.

    1993-01-01

    Although no longer on the high energy frontier, the cyclotron field is still a major scientific growth area. Its progress is highlighted at the international conference on cyclotron design, development and utilization held at intervals of about three years, under the auspices of the International Union of Pure and Applied Physics (IUPAP). Vancouver, surrounded by mountains, water and some cyclotrons, provided a pleasant setting for the 13th Conference, held last summer. With over 200 cyclotrons in operation around the world, the attendance, 241 delegates and 26 industrial exhibitors, was a near record, reflecting the flourishing state of the field. The early sessions covered the initial operation of new or upgraded cyclotron facilities. Major facilities completed since the previous Conference in Berlin in May 1989 included the 400 MeV ring cyclotron at Osaka, the U400M cyclotron at Dubna which will be coupled to the U400 to give 20 MeV nucléon uranium beams, the 130 MeV cyclotron at Jyvaskyla (in Finland, the furthest north!), the 110 MeV JAERI machine in Japan, and the 65 MeV proton therapy cyclotron in Nice. Among the facility upgrades were the KFA cyclotron at Julich which will inject the 2.5 GeV storage ring COSY, and the addition of an FM mode to the K=200 CW mode at Uppsala to give protons up to 180 MeV. The impressive current of 1.5 mA at 72 MeV obtained from the PSI Injector II will soon be injected into the 590 MeV ring

  16. Innovative Physics Teaching Conferences in the Czech Republic

    Science.gov (United States)

    Milbrandt, Rod

    2010-01-01

    Even today, with all of the instant communication technologies available, we are still often unaware of all that happens in other parts of the world. In the middle of Europe, in the Czech Republic, physics teachers have created a couple of innovative conferences--or "workshops" might be a better term. Having attended two of each, I think…

  17. 16th International Conference on Hybrid Intelligent Systems and the 8th World Congress on Nature and Biologically Inspired Computing

    CERN Document Server

    Haqiq, Abdelkrim; Alimi, Adel; Mezzour, Ghita; Rokbani, Nizar; Muda, Azah

    2017-01-01

    This book presents the latest research in hybrid intelligent systems. It includes 57 carefully selected papers from the 16th International Conference on Hybrid Intelligent Systems (HIS 2016) and the 8th World Congress on Nature and Biologically Inspired Computing (NaBIC 2016), held on November 21–23, 2016 in Marrakech, Morocco. HIS - NaBIC 2016 was jointly organized by the Machine Intelligence Research Labs (MIR Labs), USA; Hassan 1st University, Settat, Morocco and University of Sfax, Tunisia. Hybridization of intelligent systems is a promising research field in modern artificial/computational intelligence and is concerned with the development of the next generation of intelligent systems. The conference’s main aim is to inspire further exploration of the intriguing potential of hybrid intelligent systems and bio-inspired computing. As such, the book is a valuable resource for practicing engineers /scientists and researchers working in the field of computational intelligence and artificial intelligence.

  18. Department of Energy's Advanced Test Reactor (ATR), July 14--18, 1980: An independent on-site safety review

    International Nuclear Information System (INIS)

    1981-02-01

    The intent of this review was not to conduct a detailed in-depth audit, but rather to make a broad management assessment of ATR operations. The results of the review should only be considered as having identified trends or indications. The Team's observations and recommendations for the most part are based upon standards used for licensed reactor facility practices. These standards form the basis for many of the comments in this report. The Team believes that a uniform minimum standard of performance should be achieved in the operation of DOE reactors. In order to assure that this is accomplished, clear standards are necessary. Consistent with the past AEC and ERDA policy, the Team has used the standards of the commercial nuclear power industry. It is recognized that this approach is conservative, in that the ATR reactor has a significantly greater degree of inherent safety (lower pressure, temperature, power, etc.) than a licensed reactor. Although the Review Team found no indications or evidence that the plant is being operated in an unsafe manner, various areas were identified where improvements are either needed or should be considered to increase the safety of reactor operations

  19. Current Business and Economics Driven Discourse and Education: Perspectives from around the World. BCES Conference Books, Volume 15

    Science.gov (United States)

    Popov, Nikolay, Ed.; Wolhuter, Charl, Ed.; Kalin, Jana, Ed.; Hilton, Gillian, Ed.; Ogunleye, James, Ed.; Niemczyk, Ewelina, Ed.; Chigisheva, Oksana, Ed.

    2017-01-01

    This volume contains selected papers submitted to the 15th Annual International Conference of the Bulgarian Comparative Education Society (BCES), held in June 2017 in Borovets, Bulgaria, and papers submitted to the 5th International Partner Conference of the International Research Centre (IRC) "Scientific Cooperation," Rostov-on-Don,…

  20. The Crimea 96 Conference: An Orchid of the Future.

    Science.gov (United States)

    Spain, Victoria

    1997-01-01

    Describes the conference, "Libraries and Associations in the Transient World: New Technologies and New Forms of Cooperation" (3rd, Foros, Crimea, June 1-9, 1996), which aimed to promote cooperation among libraries in Russia, Ukraine, and other former Soviet Union countries. Sidebars list the English-language papers and the names and…

  1. At the frontier of astrophysics and philosophy | Public conference by Hubert Reeves | 16 July

    CERN Multimedia

    2014-01-01

    "At the frontier of astrophysics and philosophy: between infinitely large and infinitely small" Public conference by Hubert Reeves Globe of Science and Innovation Wednesday 16 July 2014 - 7.00 p.m. Please note that this conference will be in French only. "The Universe is changing.  We are not strangers in the Universe: recent discoveries in astrophysics prove our intimate bond with everything shining in the sky." Save the date! On Wednesday 16 July 2014, Hubert Reeves, astrophysicist, philosopher and engaging communicator, is back at the Globe of Science and Innovation to talk about the frontiers of physics, astronomy and philosophy, two years after the discovery of the Higgs boson at CERN. If you ever wondered how this discovery has changed our knowledge of the Universe and strengthened the bond between the infinitely large world of astrophysics and the infinitely small world of quantum physics, this event is for you. The conference is part of POPSCIENCE, a p...

  2. World energy up to the year 2020. Pt.1

    International Nuclear Information System (INIS)

    Gomez Alonso, M.

    1980-01-01

    A large report by the Conservation Commission of the World Energy Conference (''World Energy: looking ahead to 2020'') has been summarized, with some emphasis on the reference made to Spain. In this first part, orojections of primary energy demand are made for the whole world and its three main economic regions, taking into account the rising prices of energy and the possibilities of conservation. An average growth of 3% per year in world energy demand is estimated for the next decades. Also the projections for potential energy supply around the world are described, arising from the resources and reserves of the different energy sources, both conventional and unconventional, revewable and non-renewable. (auth.)

  3. Characterization of southern yellow pine bark layers by Attenuated Total Reflectance (ATR) and Fourier Transform Infrared (FT-IR) Spectroscopy

    Science.gov (United States)

    Thomas L. Eberhardt

    2009-01-01

    The outer bark (rhytidome) of the southern yellow pines is a complex structure comprised of alternating layers of obliterated phloem and periderm tissues, with the latter comprised of three layers, those being phellem, phellogen, and phelloderm. An attenuated total reflectance (ATR) sampling accessory, coupled with a Fourier transform infrared (FTIR) spectrometer,...

  4. The 6th European metallurgical conference EMC 2011: Proceedings review

    Directory of Open Access Journals (Sweden)

    Srećko R. Stopić

    2011-10-01

    Full Text Available The GDMB Society for Mining, Metallurgy, Resource and Environmental Technology organized the 6th European Metallurgical Conference (2011 in Duesseldorf from June 26 to 29, 2011. The same venue hosted the most important international metallurgical trade fairs for metallurgy of iron and steel, new casting and thermochemical processes METEC, GIFA, THERMOPROCESS and NEWCAST. The previous European metallurgical conferences were organized by GDMB in Friedrichshafen (2001, Hanover (2003, Leipzig (2005, Duesseldorf (2007, Innsbruck (2009. The GDMB is a non-profit organization situated in Clausthal in Germany, which is related to combining science with the practical experience in metallurgy, mining, materials engineering, mineral processing, recycling and refining of metals, and manufacturing of semi- and finishing products. The European Metallurgical conference EMC is one of the most known conferences worldwide in the field of non-ferrous metallurgy and is attended regularly by the decision makers from the industry and universities. The scientific program contained 6 plenary lectures and more than 160 presentations from 40 countries in 5 parallel series. An extensive poster exhibition was held, during which the authors had an opportunity to introduce their posters to the entire plenum as a part of a brief presentation. The best poster from the Montan-University in Leoben, Austria, was awarded the € 500 'Poster Award EMC 2011'. Not only were the most important European countries represented here, more than one third of the lecturers were from the non-European countries (Canada, Japan, China, USA, South Africa, Australia. The origin of the participants reflects the aim of the organizers: to make this conference a worldwide platform for the scientific exchange of experience and information. More than 400 participants from all over the world participated at this conference. The scientific presentations of the conference are presented in five Proceedings

  5. Proceedings of the Canadian Nuclear Association 26. annual conference

    International Nuclear Information System (INIS)

    1986-01-01

    The conference is being held near an imposing array of some of the world's finest nuclear reactors but in a climate for nuclear energy that poses considerable challenge for the future. Recent events at Chernobyl have deflected public attention from the reality that nuclear energy from CANDU reactors is the safest, cleanest and most economic energy option available in several parts of our country. One might well ask 'Will the Chernobyl accident result in a serious long term set-back to global recognition of the need for nuclear power?' Technically it shouldn't do so but politically it may unless the industry takes an innovative and aggressive stand towards providing the necessary assurances to the public of the excellence and safety of well designed reactors such as CANDU. The them of this conference is 'Innovation Leads the Way'. During the next two day we will hear about and discuss innovations in our activities ranging all the way from scientific, technological and market development to the concluding session on what we must now do to dissipate the cloud of Chernobyl. 'Innovation Leads the Way' is a provocative title. We all know what innovation means --changing for the better -- finding new and better ways of doing things. But where are we going? Are we innovative enough to find our way? Exploring the answers to these questions is what this conference is all about. We are seeking the way not only to maintain but to improve the world class performance of our many-facetted industry and the contribution which it can make to meeting the world's energy needs. The process should be assisted through the meaningful communication we will all engage in with friends and colleagues during these next few days. If there is one lesson the nuclear industry world-wide has learned from the events of the past few weeks it is the need for international cooperation and exchange of knowledge and information

  6. International Conference on SEMS 2012

    CERN Document Server

    Liu, Chuang; Scientific explanation and methodology of science; SEMS 2012

    2014-01-01

    This volume contains the contributed papers of invitees to SEMS 2012 who have also given talks at the conference. The invitees are experts in philosophy of science and technology from Asia (besides China), Australia, Europe, Latin America, North America, as well as from within China. The papers in this volume represent the latest work of each researcher in his or her expertise; and as a result, they give a good representation of the cutting-edge researches in diverse areas in different parts of the world.

  7. Measured thermal and fast neutron fluence rates, ATR Cycle 100-BC, April 23, 1993--May 13, 1993

    International Nuclear Information System (INIS)

    Smith, L.D.; Murray, R.K.; Rogers, J.W.

    1993-07-01

    This report contains the thermal (2200 m/s) and fast (E>1MeV) neutron fluence rate data for ATR Cycle 100-BC which were measured by the Radiation Measurements Laboratory (RML) as requested by the Power Reactor Programs (ATR Experiments) Radiation Measurements Work Order. This report contains fluence rate values corresponding to the particular elevations (relative to the 80 ft. core elevation) where the measurements were taken. The data in this report consists of (1) a table of the ATR power history and distribution, (2) a hard copy listing of all thermal and fast neutron fluence rates, (3) plots of both the thermal and fast neutron fluence rates, and (4) a magnetic record (3.5 inch diskette) containing a listing of only the fast neutron fluence rates, their assigned elevations and proper header identification of all monitor positions contained herein. The fluence rates reported are for the average power levels given in the table of power history and distribution. All open-quotes Hclose quotes holder monitor wires for this cycle are 54 inches long. All open-quotes SRclose quotes holder monitor wires for this cycle are 55 inches long. This length allows measurement of the full core region and makes the first count elevation 24.73 inches above core midplane. Due to the safety rod problems in the west lobe, open-quotes BRclose quotes holders were used in the W-1, 2, 3, and 4 positions. All open-quotes BRclose quotes holder monitor wires for this cycle are 56.25 inches long. The distance from the end of the wires to the first count position was 4.25 inches for all wires counted from this cycle. The results from the measurements in the W-1, 2, 3, 4 monitor positions indicate that the safety rod followers were rotated to a different azimuthal orientation relative to the normal orientation. The results indicate that the rotation was counterclockwise from their normal orientation. This is the same condition observed starting with Cycle 99-B

  8. Working for change in the Arab world. Advocacy for reproductive health: Arab world.

    Science.gov (United States)

    Hamand, J

    1996-01-01

    The International Conference on Population and Development (ICPD) revealed that within the Arab world there are special difficulties with regard to family planning (FP) and the status of women. There is general social opposition to women's empowerment and employment outside the home, which FP associations have to tackle. At the Cairo ICPD in 1994 the Vatican and Islamic fundamentalists formed a holy alliance against undesirable Western ideas. Eventually most Arab governments became convinced about the need for the program of action. A regional conference was also held in January 1996 on this agenda organized by the IPPF Arab World Region in Cairo to implement the program of action with the participation of 140 representatives. The question of population at the Cairo meeting was linked to economic and social development leading up to the women's conference in Beijing in 1995. At the 1996 implementation meeting the unmet need for reproductive health services was voiced along with the need for solid research in this area. FP has a vital role in social development and in combating poverty. The implementation of IPPF's Vision 2000 strategic plan also contributes to the implementation of the ICPD program of action, which deals with sex education, unsafe abortion, marginalized groups, and women's empowerment. Even Islam has come to support responsible FP for the sake of the well-being of the family. The Grand Mufti of Egypt pronounced his support for FP for health and socioeconomic reasons, for the education of girls, and for equality with men. In Arab countries the outstanding problems are early marriage, female genital mutilation, sexually transmitted diseases (STDs) and HIV, unwanted pregnancy, unsafe abortion, and ignorance about reproduction. Listening to young people, funding restrictions hampering progress, and an advocacy group of prominent leaders, and the formation of an Arab parliamentarians group on FP were other high points.

  9. The fourth Arab Impact Cratering and Astrogeology Conference (AICAC IV), April 9-12, 2017, Algiers (Algeria)

    Science.gov (United States)

    Belhaï, D.; Chennaoui-Aoudjehane, H.; Baratoux, D.; Ferrière, L.; Lamali, A.; Sahoui, R.; Lambert, P.; Ayadi, A.

    2017-09-01

    We present a report about the fourth Arab Impact Cratering and Astrogeology Conference (AICAC IV) that took place in Algiers at the USTHB (Université des Sciences et Technologie Houari Boumedienne, Algiers, Algeria) in the presence of the presidents of the USTHB and Boumerdès Universities, the Director of CRAAG (Centre de Recherche en Astronomie, Astrophysique et Géophysique), and the General Director of the National Administration for Scientific Research (NASR/DGRSDT). This series of conferences aims to promote research interest for impact cratering in the Arab world and beyond, including for instance in African countries. In spite of persistently restraining travel measures to Algeria, the fourth edition held in Algiers was marked by continuous international participation, with participants from seven different countries. This conference focused on presentations of scientific results in the research fields related to planetology, meteorites, and impact craters. In particular, the Algerian impact structures were under the spotlights during both oral and poster sessions. During this conference, the presence of freshly graduated Ph.D. students and new Ph.D. projects related to impact cratering or meteoritic science was a positive sign for the consolidation of research groups in this domain in the Arab world and Africa. Therefore, international cooperation or external support and funding are still needed to ensure the development of this scientific discipline in this part of the world.

  10. The tenth CERI [Canadian Energy Research Institute] international oil and gas markets conference

    International Nuclear Information System (INIS)

    1991-01-01

    At a conference on oil and gas markets, papers were presented on oil market instability and its impact on economic development, international energy policy, oil supply and demand, natural gas liquids sales, world gas trade, gas markets in Europe and Asia, petroleum industry activities and their relation to government, oil refining and product market developments, and the North American natural gas market. Separate abstracts have been prepared for 25 papers from this conference

  11. Small Molecules Targeting Ataxia Telangiectasia and Rad3-Related (ATR) Kinase: An Emerging way to Enhance Existing Cancer Therapy

    Czech Academy of Sciences Publication Activity Database

    Andrs, M.; Korábečný, J.; Nepovimova, E.; Jun, D.; Hodný, Zdeněk; Kuca, K.

    2016-01-01

    Roč. 16, č. 3 (2016), s. 200-208 ISSN 1568-0096 Institutional support: RVO:68378050 Keywords : Ataxia telangiectasia and Rad3-related kinase (ATR) * cancer * chemosensitization * DNA damage response * phosphatidylinositol 3-kinase-related protein kinases (PIKK) * radiosensitization * synthetic lethality Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.992, year: 2016

  12. 5th International conference on High Energy Density Laboratory Astrophysics

    CERN Document Server

    Kyrala, G.A

    2005-01-01

    During the past several years, research teams around the world have developed astrophysics-relevant utilizing high energy-density facilities such as intense lasers and z-pinches. Research is underway in many areas, such as compressible hydrodynamic mixing, strong shock phenomena, radiation flow, radiative shocks and jets, complex opacities, equations o fstat, and relativistic plasmas. Beyond this current research and the papers it is producing, plans are being made for the application, to astrophysics-relevant research, of the 2 MJ National Ignition Facility (NIF) laser at Lawrence Livermore National Laboratory; the 600 kj Ligne d'Intergration Laser (LIL) and the 2 MJ Laser Megajoule (LMJ) in Bordeaux, France; petawatt-range lasers now under construction around the world; and current and future Z pinches. The goal of this conference and these proceedings is to continue focusing and attention on this emerging research area. The conference brought together different scientists interested in this emerging new fi...

  13. Proceedings of the 3. conference: Particle track membranes and their applications

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-12-31

    The materials of the 3rd conference on Particle Track Membranes and Theirs Applications present actual state of art in the topic. The leading world institutions have presented their works on the technology of PTM production by interaction of ion beams with polymeric foils. The broad spectrum of PTM membranes have been shown, their properties have been described and their applicability discussed. A number of possible applications of PTM and also already realized in industry, medicine, biology and physical investigations have been presented. 29 lectures have been made in the course of conference.

  14. Proceedings of the 3. conference: Particle track membranes and their applications

    International Nuclear Information System (INIS)

    1994-01-01

    The materials of the 3rd conference on Particle Track Membranes and Theirs Applications present actual state of art in the topic. The leading world institutions have presented their works on the technology of PTM production by interaction of ion beams with polymeric foils. The broad spectrum of PTM membranes have been shown, their properties have been described and their applicability discussed. A number of possible applications of PTM and also already realized in industry, medicine, biology and physical investigations have been presented. 29 lectures have been made in the course of conference

  15. Identification of herbarium whole-leaf samples of Epilobium species by ATR-IR spectroscopy.

    Science.gov (United States)

    Strgulc Krajsek, Simona; Buh, Primoz; Zega, Anamarija; Kreft, Samo

    2008-02-01

    A simple, high-accuracy FT-IR method based on attenuated total reflection (ATR) was developed for the rapid determination of leaf samples of Epilobium species. The method is superior to other analytical techniques, since there is no need of laborious sample preparation such as grinding or extraction and solvent removal. A total of 70 herbarium specimens, belonging to all 13 Epilobium and to 2 Chamerion species growing in Slovenia, were analyzed. With the 100 most-informative wavenumbers in the range 700-1800 cm(-1), we obtained over 90% accuracy of species identification, with discriminant multivariate statistical analysis on the measurements made on whole dried leaves.

  16. Madrid Physics Conference

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1989-11-15

    Hard on the heels of the Lepton-Photon Symposium at Stanford in August came the International Europhysics Conference on High Energy Physics in Madrid from 6-13 September. With the two meetings held so close together, there was much overlap in the physics reported, although some teams were able to use the extra month to present new results. A notable example was the Mark II team working at Stanford's SLC linear collider, who presented new limits on the number of allowed neutrinos.The Madrid meeting attracted about 600 participants from all over the world. An initial three days of parallel sessions followed by four days of plenary talks could cover the field in depth and in breadth.

  17. Proceedings of the 16th International ECOS conference. Volume 1, 2, and 3

    DEFF Research Database (Denmark)

    Houbak, Niels; Elmegaard, Brian; Qvale, Einar Bjørn

    The members of the Organizing and the Scientific Committees of ECOS 2003 are pleased to present these Proceedings of the Conference. This is the sixteenth in the series of international conferences that started in Rome in 1987. The slogan chosen for this years conference "Bridge to Our Energy...... in recent years. ECOS 2003 distinguishes itself through the quality and quantity of the papers submitted for presentation. Without the effort of dedicated researchers and authors from all over the world, this conference could not have taken place. We recognize and appreciate the creativity and work...... overall national planning to technological development, from government-initiated development of market forces to the completely liberalized market, from government-supported development to private investment opportunities, and from centralized generation of electricity from fossil fuels to distributed...

  18. Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.

    Science.gov (United States)

    Adams, Bret R; Golding, Sarah E; Rao, Raj R; Valerie, Kristoffer

    2010-04-02

    The DNA double-strand break (DSB) is the most toxic form of DNA damage. Studies aimed at characterizing DNA repair during development suggest that homologous recombination repair (HRR) is more critical in pluripotent cells compared to differentiated somatic cells in which nonhomologous end joining (NHEJ) is dominant. We have characterized the DNA damage response (DDR) and quality of DNA double-strand break (DSB) repair in human embryonic stem cells (hESCs), and in vitro-derived neural cells. Resolution of ionizing radiation-induced foci (IRIF) was used as a surrogate for DSB repair. The resolution of gamma-H2AX foci occurred at a slower rate in hESCs compared to neural progenitors (NPs) and astrocytes perhaps reflective of more complex DSB repair in hESCs. In addition, the resolution of RAD51 foci, indicative of active homologous recombination repair (HRR), showed that hESCs as well as NPs have high capacity for HRR, whereas astrocytes do not. Importantly, the ATM kinase was shown to be critical for foci formation in astrocytes, but not in hESCs, suggesting that the DDR is different in these cells. Blocking the ATM kinase in astrocytes not only prevented the formation but also completely disassembled preformed repair foci. The ability of hESCs to form IRIF was abrogated with caffeine and siRNAs targeted against ATR, implicating that hESCs rely on ATR, rather than ATM for regulating DSB repair. This relationship dynamically changed as cells differentiated. Interestingly, while the inhibition of the DNA-PKcs kinase (and presumably non-homologous endjoining [NHEJ]) in astrocytes slowed IRIF resolution it did not in hESCs, suggesting that repair in hESCs does not utilize DNA-PKcs. Altogether, our results show that hESCs have efficient DSB repair that is largely ATR-dependent HRR, whereas astrocytes critically depend on ATM for NHEJ, which, in part, is DNA-PKcs-independent.

  19. Investigation of ATR-FTIR spectroscopy as an alternative to the Water Leach Free Acidity test for cellulose acetate-based film

    DEFF Research Database (Denmark)

    Johansen, Karin Bonde; Shashoua, Yvonne

    2005-01-01

    Cellulose acetate film loses acetate groups on ageing which results in the formation of damaging acetic acid. Water-Leach Free Acidity Test (WLFAT) is the definitive technique to quantify acidity, but requires 1g film and 26 hours. ATR-FTIR spectroscopy is a non-destructive, rapid technique which...

  20. Some Reflections on Islamization of Education since 1977 Makkah Conference: Accomplishments, Failures and Tasks Ahead

    Directory of Open Access Journals (Sweden)

    Ghulam Nabi Saqeb

    2000-06-01

    Full Text Available The revival of Islamic civilisation and culture is possible only by revitalising Islamic education and reorganising it on the basis of Islamic concepts. This opinion has been consistently voiced by leading 19th century Muslim reformers. In 1977 the First World Conference on Muslim Education was held at Makkah. The conference proved to be a major landmark in Muslim education. Over 350 Muslim scholars representing various academic fields and coming from Muslim as well as Western countries participated in this event, presented papers and approved crucial recommendations. This paper highlights the antecedents of this conference, reviews the progress achieved and failures experienced during the post-conference decades, and makes suggestions for concerted efforts to be undertaken in the 21st century towards fulfillment of the objectives of the conference.

  1. Possible limitations to SSPS use due to distribution of world population and world energy consumption centers

    Energy Technology Data Exchange (ETDEWEB)

    Claverie, M.J.; Dupas, A.P.

    1980-09-01

    Satellite solar power stations, as envisioned now, would be very large energy systems from the point of view of power output (about 5 GW) and of land requirements (more than 400 sq km for a rectenna and the associated exclusion area). These size constraints could lead to limitations in the use of SSPS in significant parts of the world, due to three main incompatibilities: too high population density, insufficient density of electrical demand, and obligation for a single power station to provide less than about 20% of the total electrical demand in a given geographical zone to assure reliability. The extent of these three possible limitations was assessed, using a future world energy model developed previously. The rationale behind this model is to divide the world into 10 deg latitude by 10 deg longitude zones, in which future electrical demands (in 2000 and 2020/2025) are computed according to energetical previsions of the Case Western Reserve University (CWRU) and of the World Energy Conference (WEC). The results are world wide maps of electrical demand densities in 2000 and 2020/2025.

  2. Support for the 38th International Conference on High Energy Physics, 3-10 August 2016

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young-Kee [Univ. of Chicago, IL (United States)

    2017-06-19

    The 38th International Conference on High Energy Physics (ICHEP) held in Chicago from August 3 to 10, 2016 was for physicists from around the world to gather to share the latest advancements in particle physics, astrophysics/cosmology, and accelerator science and to discuss plans for major future facilities. DOE funding provided partial support for space rental audio-visual services for scientific presentations at the conference.

  3. A Place at the Table? The Organization of a Pre-Conference Symposium on LGBT Issues in HRD

    Science.gov (United States)

    Schmidt, Steven W.; Githens, Rod P.

    2010-01-01

    The idea for a pre-conference session focusing on lesbian, gay, bisexual, and transgender (LGBT) issues in human resource development (HRD) seemed an appropriate topic for an international conference on HRD. The LGBT rights movement has been closely linked with the world of work and the opportunities made available through shifts from an agrarian…

  4. New particle formation events measured on board the ATR-42 aircraft during the EUCAARI campaign

    Directory of Open Access Journals (Sweden)

    S. Crumeyrolle

    2010-07-01

    Full Text Available Aerosol properties were studied during an intensive airborne measurement campaign that took place at Rotterdam in Netherlands in May 2008 within the framework of the European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI. The objective of this study is to illustrate seven events of new particle formation (NPF observed with two Condensation Particle Counters (CPCs operated on board the ATR-42 research aircraft in airsectors around Rotterdam, and to provide information on the spatial extent of the new particle formation phenomenon based on 1-s resolution measurements of ultra-fine particle (in the size range 3–10 nm diameter, denoted N3-10 hereafter concentrations. The results show that particle production occurred under the influence of different air mass origins, at different day times and over the North Sea as well as over the continent. The number concentration of freshly nucleated particles (N3-10 varied between 5000 and 100 000 cm−3 within the boundary layer (BL. Furthermore the vertical extension for all nucleation events observed on the ATR-42 never exceeded the upper limit of the BL. The horizontal extent of N3-10 could not be delimited due to inflexible flight plans which could not be modified to accommodate real-time results. However, the NPF events were observed over geographically large areas; typically the horizontal extension was about 100 km and larger.

  5. World Bioenergy 2012. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-01

    The conference of 2012 had contributions on the following themes: A: World Pellets 2012, B: Market outlook, C: Energy systems, D: Transportation, E: World biorefinery 2012, F: Sustainable bioenergy day. 52 contributions in A - D. A: World Pellets 2012 is an integrated part of World Bioenergy 2012. A three day 'conference in the conference' covering all aspects of pellets: raw material potentials, innovative pellets production systems, torrefaction, new combustion technologies, trade and market development, health and safety aspects, etc. B) Market outlook: Policy and targets for renewable energy to find an alternative to fossil energy are being put in place, increasing the demand for sustainable modern bioenergy. Global trade and improved logistics open up to the markets. To facilitate international trade in bioenergy commodities, new trading places and indexes are needed, as well as generally accepted standards. Supply and demand must meet to guarantee stable prices. In this session you learn all about current market development, including drivers like incentives and policies. C) Energy Systems: Modern bioenergy is a young industry. Therefore, technical development is rapid, with many new innovations. This session focuses on technical development in the whole bioenergy chain, from harvesting of forest residues to combustion technologies and co-firing. Optimal use of biomass through district heating or cooling - small scale and large scale - and CHP technology for electricity production. D) Transportation: Sustainable transports are one of the key challenges of tomorrow. Can we transport biomass as well as other products sustainably and at what costs? Which are the future fuels for transports and when will biofuels be viewed as profitable? Biofuels for transport are under rapid development with new methods, producers and feedstock entering the markets. The future biofuels will be produced in biorefineries, to increase profitability and optimize feed

  6. Breeding to Optimize Agriculture in a Changing World

    Directory of Open Access Journals (Sweden)

    Jiankang Wang

    2015-06-01

    Full Text Available Breeding to Optimize Chinese Agriculture (OPTICHINA was a three-year EU–China project launched in June of 2011. As designed, the project acted as a new strategic model to reinforce systematic cooperation on agricultural research between Europe and China. The OPTICHINA International Conference “Breeding to Optimize Agriculture in a Changing World” was held in Beijing, May 26–29, 2014. The conference included six thematic areas: (1 defining and protecting the yield potential of traits and genes; (2 high-throughput precision phenotyping in the field; (3 molecular technologies in modern breeding; (4 plant ideotype; (5 data analysis, data management, and bioinformatics; and (6 national challenges and opportunities for China. The 10 articles collected in this special issue represent key contributions and topics of this conference. This editorial provides a brief introduction to the OPTICHINA project, followed by the main scientific points of articles published in this special issue. Finally, outcomes from a brainstorming discussion at the end of the conference are summarized, representing the authors' opinions on trends in breeding for a changing world.

  7. Tim Berners-Lee at the RSIS conference from 8-9 December 2003.

    CERN Multimedia

    Patrice Loiez

    2003-01-01

    Tim Berners-Lee participated in the Role of Science in the Information Society conference held at CERN from 8-9 December 2003. Tim Berners-Lee developed the first network and server system that lead to the World Wide Web.

  8. Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells.

    Science.gov (United States)

    García, Víctor; Lara-Chica, Maribel; Cantarero, Irene; Sterner, Olov; Calzado, Marco A; Muñoz, Eduardo

    2016-01-26

    Galiellalactone (GL) is a fungal metabolite that presents antitumor activities on prostate cancer in vitro and in vivo. In this study we show that GL induced cell cycle arrest in G2/M phase, caspase-dependent apoptosis and also affected the microtubule organization and migration ability in DU145 cells. GL did not induce double strand DNA break but activated the ATR and ATM-mediated DNA damage response (DDR) inducing CHK1, H2AX phosphorylation (fH2AX) and CDC25C downregulation. Inhibition of the ATM/ATR activation with caffeine reverted GL-induced G2/M cell cycle arrest, apoptosis and DNA damage measured by fH2AX. In contrast, UCN-01, a CHK1 inhibitor, prevented GL-induced cell cycle arrest but enhanced apoptosis in DU145 cells. Furthermore, we found that GL did not increase the levels of intracellular ROS, but the antioxidant N-acetylcysteine (NAC) completely prevented the effects of GL on fH2AX, G2/M cell cycle arrest and apoptosis. In contrast to NAC, other antioxidants such as ambroxol and EGCG did not interfere with the activity of GL on cell cycle. GL significantly suppressed DU145 xenograft growth in vivo and induced the expression of fH2AX in the tumors. These findings identify for the first time that GL activates DDR in prostate cancer.

  9. ATR FT-IR spectroscopy on Vmh2 hydrophobin self-assembled layers for Teflon membrane bio-functionalization

    International Nuclear Information System (INIS)

    Portaccio, M.; Gravagnuolo, A.M.; Longobardi, S.; Giardina, P.; Rea, I.; De Stefano, L.; Cammarota, M.; Lepore, M.

    2015-01-01

    Graphical abstract: - Highlights: • Hydrophobin self-assembled layers on Teflon in different preparation conditions were investigated. • ATR collection data geometry allowed samples examination without any particular preparation. • Amide content, lipid/amide and carbohydrate/amide ratios of the protein layer were estimated. • Secondary structure of protein was determined for the examined samples. • FT-IR demonstrated to be of extreme relevance in monitoring hydrophobin self-assembled layers preparation. - Abstract: Surface functionalization by layers of hydrophobins, amphiphilic proteins produced by fungi offers a promising and green strategy for fabrication of biomedical and bioanalytical devices. The layering process of the Vmh2 hydrophobin from Pleurotus ostreatus on Teflon membrane has been investigated by Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) spectroscopy. In particular, protein layers obtained with hydrophobin purified with two different procedures and in various coating conditions have been examined. The layers have been characterized by quantifying the amide I and amide II band area together with the lipid/amide ratio and carbohydrate/amide ratio. This characterization can be very useful in evaluating the best purification strategy and coating conditions. Moreover the analysis of the secondary structure of the layered protein using the deconvolution procedure of amide I band indicate the prevalent contribution from β-sheet state. The results inferred by infrared spectroscopy have been also confirmed by scanning electron microscopy imaging

  10. ATR FT-IR spectroscopy on Vmh2 hydrophobin self-assembled layers for Teflon membrane bio-functionalization

    Energy Technology Data Exchange (ETDEWEB)

    Portaccio, M., E-mail: marianna.portaccio@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy); Gravagnuolo, A.M., E-mail: alfredomaria.gravagnuolo@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Longobardi, S., E-mail: sara.longobardi@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Giardina, P., E-mail: paola.giardina@unina.it [Dipartimento di Scienze Chimiche, Università “Federico II”, Via Cintia, 21- 80126 Napoli (Italy); Rea, I., E-mail: ilaria.rea@na.imm.cnr.it [Institute for Microelectronics and Microsystems, CNR, Via P. Castellino, 111-80131 Napoli (Italy); De Stefano, L., E-mail: luca.destefano@na.imm.cnr.it [Institute for Microelectronics and Microsystems, CNR, Via P. Castellino, 111-80131 Napoli (Italy); Cammarota, M., E-mail: marcella.cammarota@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy); Lepore, M., E-mail: maria.lepore@unina2.it [Dipartimento di Medicina Sperimentale – Seconda Università di Napoli, Via S.M. di Costantinopoli, 16-80134 Napoli (Italy)

    2015-10-01

    Graphical abstract: - Highlights: • Hydrophobin self-assembled layers on Teflon in different preparation conditions were investigated. • ATR collection data geometry allowed samples examination without any particular preparation. • Amide content, lipid/amide and carbohydrate/amide ratios of the protein layer were estimated. • Secondary structure of protein was determined for the examined samples. • FT-IR demonstrated to be of extreme relevance in monitoring hydrophobin self-assembled layers preparation. - Abstract: Surface functionalization by layers of hydrophobins, amphiphilic proteins produced by fungi offers a promising and green strategy for fabrication of biomedical and bioanalytical devices. The layering process of the Vmh2 hydrophobin from Pleurotus ostreatus on Teflon membrane has been investigated by Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) spectroscopy. In particular, protein layers obtained with hydrophobin purified with two different procedures and in various coating conditions have been examined. The layers have been characterized by quantifying the amide I and amide II band area together with the lipid/amide ratio and carbohydrate/amide ratio. This characterization can be very useful in evaluating the best purification strategy and coating conditions. Moreover the analysis of the secondary structure of the layered protein using the deconvolution procedure of amide I band indicate the prevalent contribution from β-sheet state. The results inferred by infrared spectroscopy have been also confirmed by scanning electron microscopy imaging.

  11. NANOTR9: 9th Nanoscience and Nanotechnology Conference

    Science.gov (United States)

    2014-11-01

    The conference series NanoTR is the major conference on nanoscience and nanotechnology in Turkey. It brings together leading scientists and engineers in nanotechnology to exchange information on their latest research progress. An exhibition of the companies working in the related field is also organized as a part of the event. With intensive international participation, NanoTR conference series has spread outside the national border and has become an international event in this field. Among international contributions, a wide interest from the countries around Turkey should be emphasized. 9th in the series was organized by Atatürk University in Erzurum-Turkey on June 24-28, 2013 with more than 900 scientists, researchers, private sector representatives from around the world. Conference program included 6 plenary speakers, 35 invited speakers (18 of them were from outside the country), 116 oral presentations, and 340 poster presentations. In addition to 6 plenary sessions, 17 oral and 4 poster sessions created very lively discussion forums covering a vast range of current and emerging sciences from nano-materials, nanoscience, nanofabrication, nano-engineering, nano-electronics, nano-biotechnology, to ethical and social issues of nanoscience and nanotechnology. Also, panel discussions about industrial applications, tutorial sessions have been organized for students, new-comers and company employees.

  12. CERN to host conference on the Role of Science in the Information Society

    CERN Multimedia

    2003-01-01

    "On December 8-9, CERN will host the Role of Science in the Information Society (RSIS) conference, together with UNESCO, the International Council for Science, and the Third World Academy of Sciences. A Summit Event to the first phase of the World Summit on the Information Society (Geneva, December 10-12), RSIS is a grassroots initiative to bring science into the picture of the Summit" (1 page).

  13. PREFACE Conference on Advanced Materials and Nanotechnology (CAMAN 2009)

    Science.gov (United States)

    Ali, Aidy

    2011-02-01

    This special issue of IOP Conference Series: Materials science and Engineering contains papers contributed to the Conference on Advanced Materials and Nanotechnology (CAMAN 2009) held on 3-5 November 2009 in Putra World Trade Centre (PWTC), Kuala Lumpur, Malaysia. The objective of the congress is to provide a platform for professionals, academicians and researchers to exchange views, findings, ideas and experiences on advanced science and technology. After careful refereeing of all manuscripts, 50 papers were selected for publications in this issue. The policy of editing was the content of the material and its rapid dissemination was more important than its form. In 2009, the conference received close to 120 papers from leading researchers and participants from countries such as Iran, India, Switzerland, Myanmar, Nigeria, Canada, Yemen and Malaysia. We strongly hope the new ideas and results presented will stimulate and enhance the progress of research on the above conference theme. We are grateful to all the authors for their papers and presentations in this conference. They are also the ones who help make this conference possible through their hard work in the preparation of the manuscripts. We would also like to offer our sincere thanks to all the invited speakers who came to share their knowledge with us. We would also like to acknowledge the untiring efforts of the reviewers, research assistants and students in meeting deadlines and for their patience and perseverance. We wish to thank all the authors who contributed papers to the conference and all reviewers for their efforts to review the papers as well as the sponsors. We would also like to thank the members of the CAMAN 2009 Organising Committee and the International Advisory Committee for their efforts in making the conference a success. Thank you very much indeed. Guest Editor Aidy Ali

  14. Nuclear Electronics. Proceedings of a Conference on Nuclear Electronics

    International Nuclear Information System (INIS)

    1966-01-01

    The science of electronics, which is playing a decisive role in the modern world, is particularly important in the development of the nuclear sciences, both in fundamental research on the structure of matter and in the production of power from fission. It is impractical, however, to deal with this vast and varied subject at one time. The Agency's first conference on the subject, at Belgrade in May 1961, was restricted to just a few aspects of nuclear electronics. The second conference, organized by the Agency in co-operation with the Indian Atomic Energy Commission and held at Bombay from 22 to 26 November 1965, was limited, for all practical purposes, to the use of nuclear electronics in reactor control and safety. The importance of this subject is self-evident, for the number of power reactors throughout the world is increasing every year and the economics of their operation depends just as much on optimum functioning as on improved safety. The Bombay conference, at which 48 papers were presented, was attended by a large number of participants, representing 12 countries and two international organizations. The main topics were power and neutron-flux measurements, reactor control, safety devices, and data processing to ensure optimum operation. The Proceedings, which contain both the texts and discussions of the papers presented, are of immediate interest to specialists in these fields and should form a valuable source of information

  15. 76 FR 64083 - Reliability Technical Conference; Notice of Technical Conference

    Science.gov (United States)

    2011-10-17

    ... Technical Conference; Notice of Technical Conference Take notice that the Federal Energy Regulatory Commission will hold a Technical Conference on Tuesday, November 29, 2011, from 1 p.m. to 5 p.m. and... reliability that were identified in earlier Commission technical conferences. The conference also will discuss...

  16. 4th European Conference on Geostatistics for Environmental Applications

    CERN Document Server

    Carrera, Jesus; Gómez-Hernández, José

    2004-01-01

    The fourth edition of the European Conference on Geostatistics for Environmental Applications (geoENV IV) took place in Barcelona, November 27-29, 2002. As a proof that there is an increasing interest in environmental issues in the geostatistical community, the conference attracted over 100 participants, mostly Europeans (up to 10 European countries were represented), but also from other countries in the world. Only 46 contributions, selected out of around 100 submitted papers, were invited to be presented orally during the conference. Additionally 30 authors were invited to present their work in poster format during a special session. All oral and poster contributors were invited to submit their work to be considered for publication in this Kluwer series. All papers underwent a reviewing process, which consisted on two reviewers for oral presentations and one reviewer for posters. The book opens with one keynote paper by Philippe Naveau. It is followed by 40 papers that correspond to those presented orally d...

  17. 7th International Conference on Genetic and Evolutionary Computing

    CERN Document Server

    Krömer, Pavel; Snášel, Václav

    2014-01-01

    Genetic and Evolutionary Computing This volume of Advances in Intelligent Systems and Computing contains accepted papers presented at ICGEC 2013, the 7th International Conference on Genetic and Evolutionary Computing. The conference this year was technically co-sponsored by The Waseda University in Japan, Kaohsiung University of Applied Science in Taiwan, and VSB-Technical University of Ostrava. ICGEC 2013 was held in Prague, Czech Republic. Prague is one of the most beautiful cities in the world whose magical atmosphere has been shaped over ten centuries. Places of the greatest tourist interest are on the Royal Route running from the Powder Tower through Celetna Street to Old Town Square, then across Charles Bridge through the Lesser Town up to the Hradcany Castle. One should not miss the Jewish Town, and the National Gallery with its fine collection of Czech Gothic art, collection of old European art, and a beautiful collection of French art. The conference was intended as an international forum for the res...

  18. Conference on the treatment of tinnitus and hyperacusis - Postponed

    CERN Multimedia

    GS Department

    2010-01-01

    Please note that the conference on the treatment of tinnitus and hyperacusis initially scheduled for Thursday, 3 March 2010 has been postponed to Monday, 2 May 2010 It will take place from 2.30 p.m. to 4.30 p.m. in the IT Auditorium - Building 31 3-004 Sylviane Chéry-Croze, Honorary Research Director at the CNRS and Ange Bidan, Vice-President of the French Association of Tinnitus Sufferers Do you suffer from tinnitus or hyperacusis? The CERN Medical Service and UNIQA Assurances SA, Geneva, invite you to a conference organised by the French Association of Tinnitus Sufferers. The conference will start with an introduction devoted to the destabilising experiences of people suffering from these symptoms and to the reactions that they induce. This introduction will be followed by a presentation of what are universally assumed in the medical research world to be the causes of the most frequently encountered forms of tinnitus (neurosensorial tinnitus). The presentation will also describe the mu...

  19. 7th Rochester Conference on Coherence and Quantum Optics

    CERN Document Server

    Mandel, Leonard; Wolf, Emil

    1996-01-01

    The Seventh Rochester Conference on Coherence and Quantum Optics was held on the campus of the University of Rochester during the four-day period June 7 - 10, 1996. More than 280 scientists from 33 countries participated. This book contains the Proceedings of the meeting. This Conference differed from the previous six in the series in having only a limited number of oral presentations, in order to avoid too many parallel sessions. Another new feature was the introduction of tutorial lectures. Most contributed papers were presented in poster sessions. The Conference was sponsored by the American Physical Society, by the Optical Society of America, by the International Union of Pure and Applied Physics and by the University of Rochester. We wish to express our appreciation to these organizations for their support and we especially extend our thanks to the International Union of Pure and Applied Physics for providing financial assistance to a number of speakers from Third World countries, to enable them to take ...

  20. Revisiting the Brønsted acid catalysed hydrolysis kinetics of polymeric carbohydrates in ionic liquids by in situ ATR-FTIR spectroscopy

    DEFF Research Database (Denmark)

    Kunov-Kruse, Andreas Jonas; Riisager, Anders; Shunmugavel, Saravanamurugan

    2013-01-01

    A new versatile method to measure rates and determine activation energies for the Brønsted acid catalysed hydrolysis of cellulose and cellobiose (and other polymeric carbohydrates) in ionic liquids is demonstrated by following the C–O stretching band of the glycoside bond with in situ ATR...