Kazuyoshi Yagi; Atsuo Nakamura; Atsuo Sekine; David Graham
Atrophic gastritis, whether caused by Helicobacter pylori infection or as a result of an autoimmune process, is associated with corpus atrophy. However, whereas atrophic gastritis caused by H. pylori involves the antrum, the antrum is spared in autoimmune gastritis. Here, we report the use of magnifying endoscopy to identify and distinguish atrophic gastritis caused by H. pylori from autoimmune gastritis. The mucosal pattern in autoimmune gastritis is that of closely arranged small round and ...
Lea; Irene; Veijola; Aino; Mirjam; Oksanen; Pentti; Ilmari; Sipponen; Hilpi; Iris; Kaarina; Rautelin
AIM:To study the association between Helicobacter pylori(H.pylori)infection and autoimmune type atrophic gastritis. METHODS:Twenty-three patients with different grades of atrophic gastritis were analysed using enzyme immunoassay-based serology,immunoblot-based serology,and histology to reveal a past or a present H.pylori infection.In addition,serum markers for gastric atrophy(pepsinogenⅠ,pepsinogenⅠ/Ⅱand gastrin)and autoimmunity[parietal cell antibodies(PCA), and intrinsic factor(IF),antibodies]were determi...
Ricuarte, O; Gutierrez, O.; Cardona, H; Kim, J. G.; Graham, D Y; El-Zimaity, H M T
Background: Helicobacter pylori associated gastric cancer arises via a multistage process, with atrophic gastritis being the precursor lesion. Helicobacter pylori is typically acquired in childhood, yet little is known of the prevalence of atrophic gastritis in childhood.
Oksanen, A.; Sipponen, P; Karttunen, R.; Miettinen, A.; Veijola, L; S. Sarna; Rautelin, H
BACKGROUND—Atrophic gastritis has been shown to be one of the long term sequelae of Helicobacter pylori infection. AIMS—To determine the prevalence of atrophic gastritis in outpatients, to study the accuracy of serological methods for revealing atrophy, and to define the association of H pylori infection with atrophic gastritis in these patients. PATIENTS/METHODS—A total of 207 consecutive outpatients referred for gastroscopy were included. Biopsy specimens from the antrum and corpus were ass...
Full Text Available Objective. Gastric acid plays an important part in the prevention of bacterial colonization of the gastrointestinal tract. If these bacteria have an ability of hydrogen (H2 fermentation, intraluminal H2 gas might be detected. We attempted to measure the intraluminal H2 concentrations to determine the bacterial overgrowth in the gastrointestinal tract. Patients and methods. Studies were performed in 647 consecutive patients undergoing upper endoscopy. At the time of endoscopic examination, we intubated the stomach and the descending part of the duodenum without inflation by air, and 20Ã¢Â€Â‰mL of intraluminal gas samples of both sites was collected through the biopsy channel. Intraluminal H2 concentrations were measured by gas chromatography. Results. Intragastric and intraduodenal H2 gas was detected in 566 (87.5% and 524 (81.0% patients, respectively. The mean values of intragastric and intraduodenal H2 gas were 8.5Ã‚Â±15.9 and 13.2Ã‚Â±58.0Ã¢Â€Â‰ppm, respectively. The intraduodenal H2 level was increased with the progression of atrophic gastritis, whereas the intragastric H2 level was the highest in patients without atrophic gastritis. Conclusions. The intraduodenal hydrogen levels were increased with the progression of atrophic gastritis. It is likely that the influence of hypochlorhydria on bacterial overgrowth in the proximal small intestine is more pronounced, compared to that in the stomach.
Yan-Cheng Dai; Zhi-Peng Tang; Ya-Li Zhang
Atrophic gastritis, is the main consequence of long-standing Helicobacter pylori infection, and is linked to the development of gastric cancer. The severity of atrophic gastritis is related to the lifetime risk of gastric cancer development, especially in terms of its degree and extent of mucosal damage. Therefore, it is important for clinicians to assess the severity of atrophic gastritis, interfere with the disease progress, and reverse gastric mucosal atrophy. In the article, we demonstrated some methods (conventional endoscopy, modern endoscopic technology and noninvasive methods) that may help assess the severity of atrophic gastritis and select the reasonable treatment protocols.
El-Serag, H; Sonnenberg, A.; Jamal, M.; Inadomi, J; Crooks, L.; Feddersen, R
BACKGROUND—Gastric acid is important in the pathogenesis of reflux oesophagitis. Acid production by the gastric corpus is reduced in corpus gastritis. AIMS—To determine whether corpus gastritis protects against reflux oesophagitis. METHODS—Patients presenting for elective oesophagogastroduodenoscopy were studied. Two biopsy specimens were taken from the antrum, corpus, and cardia and stained with haematoxylin/eosin and Diff-Quick II stains. The presence and severity of gastritis were graded a...
Aim: The aim of this prospective study was to evaluate whether helicobacter pylori eradication could improve gastric atropy or intestinal metaplasia. Material and Method: Forty-two pylori infected patients were evaluated for the status of atrophic gastritis and intestinal metaplasia. Two biopsy specimens from antrum and two biopsy specimens from corpus were taken before and 6 months after the helicobacter pylori eradication therapy. Helicobacter pylori status was determined by C-urea br...
Xue, Zeyun; Xue, Huiping; Jiang, Jianlan; Lin, Bing; Zeng, Si; Huang, Xiaoyun; An, Jianfu
The objective of this study was to explore hair mercury level in association with chronic atrophic gastritis, a precancerous stage of gastric cancer (GC), and thus provide a brand new angle of view on the timely intervention of precancerous stage of GC. We recruited 149 healthy volunteers as controls and 152 patients suffering from chronic gastritis as cases. The controls denied upper gastrointestinal discomforts, and the cases were diagnosed as chronic superficial gastritis (n=68) or chronic atrophic gastritis (n=84). We utilized Mercury Automated Analyzer (NIC MA-3000) to detect hair mercury level of both healthy controls and cases of chronic gastritis. The statistic of measurement data was expressed as mean ± standard deviation, which was analyzed using Levene variance equality test and t test. Pearson correlation analysis was employed to determine associated factors affecting hair mercury levels, and multiple stepwise regression analysis was performed to deduce regression equations. Statistical significance is considered if p value is less than 0.05. The overall hair mercury level was 0.908949 ± 0.8844490 ng/g [mean ± standard deviation (SD)] in gastritis cases and 0.460198 ± 0.2712187 ng/g (mean±SD) in healthy controls; the former level was significantly higher than the latter one (p=0.000healthy controls (phealthy controls (phealthy controls with eating seafood was significantly higher than that in healthy controls without eating seafood (peating seafood was most correlated with hair mercury level and positively correlated in the healthy controls and that the severity of gastritis was most correlated with hair mercury level and positively correlated in the gastritis cases. Multiple stepwise regression analysis indicated that the regression equation of hair mercury level in controls could be expressed as 0.262 multiplied the value of eating seafood plus 0.434, the model that was statistically significant (pfactor affecting the hair mercury level is eating
@@ Having been engaged in clinical practice for 40 years,Prof. Shah Zhaowei of Jiangsu Provincial Hospital of Traditional Chinese Medicine is good at treating chronic atrophic gastritis (CAG). In clinical practice,he often pays great attention to the combination of TCM syndrome-differentiation with diseasedifferentiation as well as the combination of macroscopic differentiation with microscopic differentiation. The therapeutic method he adopts or the drugs he prescribes are both simple and clear,often leading to remarkably therapeutic results. The following is a brief introduction to his clinical experience on the treatment of chronic atrophic gastritis (CAG).
Marotta, F; Hayakawa, K.; Mikami, Y.; Morello, P; Sugai, M; Morita, T
The aim of our study was to investigate the relationship between gastrin producing cell density with antral mucosa, luminal and serum gastrin concentration in antral atrophic gastritis. Our study group consisted of 17 patients: six with mild atrophic gastritis, seven with moderate atrophic gastritis and four with severe atrophic gastritis. None of the patients had type-A atrophic gastritis but the body mucosa was affected by superficial gastritis at various extent in some. A group of 15 healt...
Lee, Ju Yup; Kim, Nayoung; Lee, Hye Seung; Oh, Jane C.; Kwon, Yong Hwan; Choi, Yoon Jin; Yoon, Ki Chul; Hwang, Jae Jin; Lee, Hyun Joo; Lee, AeRa; Jeong, Yeonsang; Jo, Hyun Jin; Yoon, Hyuk; Shin, Cheol Min; Park, Young Soo
Background: Atrophic gastritis is a precancerous condition, which can be diagnosed by several methods. However, there is no consensus for the standard method. The aim of this study was to evaluate the correlations among endoscopic, histologic, and serologic findings for the diagnosis of atrophic gastritis. Methods: From March 2003 to August 2013, a total of 2,558 subjects were enrolled. Endoscopic atrophic gastritis was graded by Kimura-Takemoto classification and histological atrophic gastri...
Full Text Available Background/Aim. Hepcidin, an iron regulatory hormone, is increased in response to inflammation and some infections. We investigated the relationships among serum prohepcidin, iron status, Helicobacter pylori infection status, and the presence of gastric mucosal atrophy. Methods. Seventy subjects undergoing esophagogastroduodenoscopy underwent multiple gastric biopsies, and the possibility of H. pylori infection and the degree of endoscopic and histologic gastritis were investigated. In all subjects, serum prohepcidin and iron parameters were evaluated. Results. No correlations were observed between serum prohepcidin levels and the other markers of anemia, such as hemoglobin, serum iron, ferritin, and total iron binding capacity. Serum prohepcidin levels were not significantly different between the H. pylori-positive group and the H. pylori-negative group. Serum prohepcidin levels in atrophic gastritis patients were significantly lower than those in subjects without atrophic gastritis irrespective of H. pylori infection. Conclusion. Serum prohepcidin levels were not altered by H. pylori infection. Serum prohepcidin levels decrease in patients with atrophic gastritis, irrespective of H. pylori infection. It suggests that hepcidin may decrease due to gastric atrophy, a condition that causes a loss of hepcidin-producing parietal cells. Further investigations with a larger number of patients are necessary to substantiate this point.
Shaohua Chen; Lixiong Ying; Mei Kong; Yu Zhang; Youming Li
The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased significantly with increased age. H. pylori infection was present in 21.01% of chronic atrophic gastritis patients, and 92.33% of the subjects with H. pylori infection were found to have simultaneous ...
高希言; 饶红; 王燕; 孟丹; 魏玉龙
Objective: To probe the mechanism of acupuncture and moxibustion in atrophic gastritis so as to provide a basis for clinical treatment. Method: Observe the effects of acupuncture and moxibustion at the points of Zusanli, Zhongwan and Tianshu on gastric mucosa in model rats with chronic atrophic gastritis. Results:Acupuncture and moxibustion can increase the contents of PGE2α, PGF2α and cAMP, and decrease the content of cGMP in the tissue of gastric mucosa. Conclusion: Acupuncture and moxibustion shows cytoprotection on gastric mucosa, so it is an effective method for treating chronic atrophic gastritis.
Background and aims: The development of atrophic chronic gastritis (ACG) is multifactorial, involving environment as well as host responses to Helicobacter pylori infection. The aim of this study was to determine factors involved in ACG in a European dyspeptic population.
Li, Zhong-Wu; Wu, Ying; SUN, YU; LIU, LU-YING; Tian, Meng-Meng; Feng, Guo-Shuang; You, Wei-cheng; Li, Ji-You
AIM: To investigate the effects of interleukin-8 (IL-8), macrophage migration inhibitory factor (MIF) gene polymorphisms, Helicobacter pylori (H. pylori) infection, on the risk of developing severe chronic atrophic gastritis (SCAG) and intestinal metaplasia (IM).
Wang, Xu; Ling, Li; Li, Shanshan; Qin, Guiping; Cui, Wei; Li, Xiang; Ni, Hong
Abstract A meta-analysis was performed to assess the diagnostic value of gastrin-17 (G-17) for the early detection of chronic atrophic gastritis (CAG). An extensive literature search was performed, with the aim of selecting publications that reported the accuracy of G-17 in predicting CAG, in the following databases: PubMed, Science Direct, Web of Science, Chinese Biological Medicine, Chinese National Knowledge Infrastructure, Wanfang, and VIP. To assess the diagnostic value of G-17, the following statistics were estimated and described: sensitivity, specificity, diagnostic odds ratios (DOR), summary receiver operating characteristic curves, area under the curve (AUC), and 95% confidence intervals (CIs). Thirteen studies that met the inclusion criteria were included in this meta-analysis, comprising 894 patients and 1950 controls. The pooled sensitivity and specificity of these studies were 0.48 (95% CI: 0.45–0.51) and 0.79 (95% CI: 0.77–0.81), respectively. The DOR was 5.93 (95% CI: 2.93–11.99), and the AUC was 0.82. G-17 may have potential diagnostic value because it has good specificity and a moderate DOR and AUC for CAG. However, more studies are needed to improve the sensitivity of this diagnostic tool in the future. PMID:27149493
Full Text Available Chronic atrophic gastritis (CAG is a very common gastritis and one of the major precursor lesions of gastric cancer, one of the most common cancers worldwide. The molecular mechanism underlying CAG is unclear, but its elucidation is essential for the prevention and early detection of gastric cancer and appropriate intervention. A combination of two-dimensional gel electrophoresis and mass spectrometry was used in the present study to analyze the differentially expressed proteins. Samples from 21 patients (9 females and 12 males; mean age: 61.8 years were used. We identified 18 differentially expressed proteins in CAG compared with matched normal mucosa. Eight proteins were up-regulated and 10 down-regulated in CAG when compared with the same amounts of proteins in individually matched normal gastric mucosa. Two novel proteins, proteasome activator subunit 1 (PSME1, which was down-regulated in CAG, and ribosomal protein S12 (RPS12, which was up-regulated in CAG, were further investigated. Their expression was validated by Western blot and RT-PCR in 15 CAG samples matched with normal mucosa. The expression level of RPS12 was significantly higher in CAG than in matched normal gastric mucosa (P < 0.05. In contrast, the expression level of PSME1 in CAG was significantly lower than in matched normal gastric mucosa (P < 0.05. This study clearly demonstrated that there are some changes in protein expression between CAG and normal mucosa. In these changes, down-regulation of PSME1 and up-regulation of RPS12 could be involved in the development of CAG. Thus, the differentially expressed proteins might play important roles in CAG as functional molecules.
Chronic atrophic gastritis (CAG) is a very common gastritis and one of the major precursor lesions of gastric cancer, one of the most common cancers worldwide. The molecular mechanism underlying CAG is unclear, but its elucidation is essential for the prevention and early detection of gastric cancer and appropriate intervention. A combination of two-dimensional gel electrophoresis and mass spectrometry was used in the present study to analyze the differentially expressed proteins. Samples from 21 patients (9 females and 12 males; mean age: 61.8 years) were used. We identified 18 differentially expressed proteins in CAG compared with matched normal mucosa. Eight proteins were up-regulated and 10 down-regulated in CAG when compared with the same amounts of proteins in individually matched normal gastric mucosa. Two novel proteins, proteasome activator subunit 1 (PSME1), which was down-regulated in CAG, and ribosomal protein S12 (RPS12), which was up-regulated in CAG, were further investigated. Their expression was validated by Western blot and RT-PCR in 15 CAG samples matched with normal mucosa. The expression level of RPS12 was significantly higher in CAG than in matched normal gastric mucosa (P < 0.05). In contrast, the expression level of PSME1 in CAG was significantly lower than in matched normal gastric mucosa (P < 0.05). This study clearly demonstrated that there are some changes in protein expression between CAG and normal mucosa. In these changes, down-regulation of PSME1 and up-regulation of RPS12 could be involved in the development of CAG. Thus, the differentially expressed proteins might play important roles in CAG as functional molecules
Zhang, Lin; Hou, Yanhong; Wu, Kai; Li, Dan [Department of Gastroenterology and Hepatology, The 309 Hospital of People' s Liberation Army, Beijing (China)
Chronic atrophic gastritis (CAG) is a very common gastritis and one of the major precursor lesions of gastric cancer, one of the most common cancers worldwide. The molecular mechanism underlying CAG is unclear, but its elucidation is essential for the prevention and early detection of gastric cancer and appropriate intervention. A combination of two-dimensional gel electrophoresis and mass spectrometry was used in the present study to analyze the differentially expressed proteins. Samples from 21 patients (9 females and 12 males; mean age: 61.8 years) were used. We identified 18 differentially expressed proteins in CAG compared with matched normal mucosa. Eight proteins were up-regulated and 10 down-regulated in CAG when compared with the same amounts of proteins in individually matched normal gastric mucosa. Two novel proteins, proteasome activator subunit 1 (PSME1), which was down-regulated in CAG, and ribosomal protein S12 (RPS12), which was up-regulated in CAG, were further investigated. Their expression was validated by Western blot and RT-PCR in 15 CAG samples matched with normal mucosa. The expression level of RPS12 was significantly higher in CAG than in matched normal gastric mucosa (P < 0.05). In contrast, the expression level of PSME1 in CAG was significantly lower than in matched normal gastric mucosa (P < 0.05). This study clearly demonstrated that there are some changes in protein expression between CAG and normal mucosa. In these changes, down-regulation of PSME1 and up-regulation of RPS12 could be involved in the development of CAG. Thus, the differentially expressed proteins might play important roles in CAG as functional molecules.
Full Text Available The clinical pathological characteristics of 3969 adult patients with chronic atrophic gastritis were retrospectively studied. The positivity of intestinal metaplasia and dysplasia in atrophic gastric specimens increased with age; however, H. pylori positivity and inflammatory activity decreased significantly with increased age. H. pylori infection was present in 21.01% of chronic atrophic gastritis patients, and 92.33% of the subjects with H. pylori infection were found to have simultaneous inflammatory activity. The intestinal metaplasia and dysplasia positivity markedly increased as the degree of gastric atrophy increased. In conclusion, the incidence of H. pylori infection decreased with age and correlated significantly with inflammatory activity in atrophic gastritis patients. The intestinal metaplasia and dysplasia positivity notably increased as the degree of gastric atrophy increased. Large population-based prospective studies are needed to better understand the progression of CAG.
AIM:To investigate the association between Ser326Cys human oxoguanine glycosylase 1(hOGG1) polymorphism and atrophic gastritis and gastric cancer after Helicobacter pylori(H.pylori) eradication.METHODS:A total of 488 subjects(73 patients with gastric cancer,160 with atrophic gastritis after H.pylori eradication and 255 controls) were prospectively collected.Polymerase chain reaction-restriction fragment length polymorphism analysis was performed to distinguish hOGG1 Ser326Cys polymorphism.Statistical analys...
AIM: To investigate the effects of interleukin-8 (IL-8 ), macrophage migration inhibitory factor (MIF ) gene polymorphisms, Helicobacter pylori (H. pylori ) infection, on the risk of developing severe chronic atrophic gastritis (SCAG) and intestinal metaplasia (IM). METHODS: A total of 372 cases were selected from a cohort study in Linqu County, a high risk area for gastric cancer (GC) in northern China. To obtain a sufficient group size, patients with normal or superficial gastritis were included. Based on...
Mehmet Cindoruk; Ilhan Yetkin; Serpil Muge Deger; Tarkan Karakan; Erdal Kan; Selahattin Unal
AIM: To determine the association between H pylori infection and serum ghrelin levels in patients without atrophic gastritis.METHODS: Fifty consecutive patients (24 males and 26 females) with either H pylori-positive gastritis (n = 34) or H pylori-negative gastritis (n = 16) with normal gastric acid secretion determined by 24-h pHmetry and without atrophic gastritis in histopathology were enrolled in this study. Thirty-four H pylori-infected patients were treated with triple therapy consisting of a daily regimen of 30 mg lansoprazole bid, 1 g amoxicillin bid and 500 mg clarithromycin bid for 14 d, followed by an additional 4 wk of 30 mg lansoprazol treatment. H pylori infection was eradicated in 23 of 34 (67.6%) patients. H pylori-positive patients were given eradication therapy. Gastric acidity was determined via intragastric pH catethers. Serum ghrelin was measured by radioimmunoassay (RIA).RESULTS: There was no significant difference in plasma ghrelin levels between H pylori -positive and H pylori-negative groups (81.10 ± 162.66 ng/L vs 76.51 ± 122.94 ng/L). In addition, there was no significant difference in plasma ghrelin levels and gastric acidity levels measured before and 3 mo after the eradication therapy.CONCLUSION: H pylori infection does not influence ghrelin secretion in patients with chronic gastritis without atrophic gastritis.
Ananthamurugan; Saleem; Gopal; Sunil Shivekar; Kaviraj; Balamurugan
BACKGROUND: Helicobacter pylori is the most common human pathogen which causes chronic gastritis, leading to serious complications. The aim was to study the incidence of H. pylori infection and the risk factors associated with chronic atrophic gastritis using simple diagnostic procedures. MATERIALS AND METHODS: Biopsy samples were collected from 146 chronic atrophic gastritis patients. Rapid Urease Test (RUT) and dark field microscopy were used to diagnose the presence of H. p...
This paper discussed with the feasibility of using 3H-TdR autoraoiography in vitro incubation to evaluate the therapeutic effect of atrophic gastritis. The results showed that gastric mucosa labelling indices measured by autoradiography can reflect the property, severity and clincal conditions of chronic gastritis quantitatively. The methodology is raliable and reproducible. It was suggested that labelling indices may serve as a cytokinetic parameter to evaluate the therapeutic effect of atrophic gastritis
Gao Xiyan; Yuan Jing; Li Huijuan; Ren Shan
Objective: To observe the clinical therapeutic effects of acupuncture and moxibustion in treating chronic atrophic gastritis. Methods: Patients who met the criteria were randomly divided into the treatment groups consisting of the acupuncture group (30 cases) and the acupuncture-moxibustion group (30 cases), and the control group (28 cases). After two months of treatment, observed were safety and the curative effects,through general physical check ups, routine examinations of blood, urine and feces, and symptoms,pathology and gastrin before, during and after the treatment. Results: 1) The treatment groups showed significant superiorities in the improvement of symptoms, with the acupuncture-moxibustion group showing the best therapeutic effects. 2) The acupuncture-moxibustion group showed marked differences before and after the treatment in the improvement of glandular atrophy and intestinal metaplasia, with a total effective rate of 66.67%. 3) After the treatment, the three groups all showed marked improvement in the level of serum gastrin, with the acupuncture-moxibustion group showing the best effects. Conclusion: Acupuncture and moxibustion have definite therapeutic effects for chronic atrophic gastritis, especially in improving the symptoms. Acupuncture or acupuncture combined with moxibustion can provide possibilities in reversing the pathologic changes of glandular atrophy and intestinal metaplasia for patients with chronic atrophic gastritis. Acupuncture-moxibustion is really an effective and safe therapy for chronic atrophic gastritis.
Wei-li LIU; Shu-jie CHEN; Yan CHEN; Lei-min SUN; Wei ZHANG; Ya-min ZENG; Tian-hua ZHOU; Jian-min SI
Aim: To investigate the effect of geranylgeranylacetone (GGA) on the progres-sion of atrophic gastritis in rats and its potential mechanism. Methods: Atrophic gastritis was induced in Sprague-Dawley rats with 0.1% ammonia solution, 60% ethanol, and 20 mmol/L deoxycholic acid for 24 weeks. Accompanied by the induction of atrophic gastritis, 200 mg/kg GGA was administered by oral gavage for 8 weeks (weeks 17-24). The histological changes in gastric mucosa were quantitated by the index of inflammation, the gastric mucosal thickness, and the amount of glands of 1 mm horizontal length in antrum. Endogenous heat shock protein (HSP)70 levels and distribution were determined by immunoblotting and immunohistochemistry in gastric mucosa. Results: GGA alleviated the pathologi-cal progression of atrophic gastritis with inflammation relief (inflammation index: 1.40 in the GGA group and 1.65 in the atrophic gastritis group) and glandular restoration (rnucosal thickness and quantity of glands: 194.3 μm and 38.7 mm in the GGA group; 123.3 μm and 32.7 mm in the atrophic gastritis group; P<0.05). GGA significantly induced HSP70 synthesis (P<0.05). Moreover, quercetin, an inhibitor of HSP70 expression, aggravated the infiltration of inflammatory cells and glandular loss in the antrum. Conclusion: GGA prevented the progression of atrophic gastritis in rats via the induction of HSP70 expression.
Full Text Available BACKGROUND: Most studies about aquaporin 3 (AQP3 in the gastrointestinal tract were carried out on both in vivo and in vitro. The role of AQP3-mediated water transport in human gastrointestinal tract is still unclear. Our aim in this study was to explore the expression of AQP3 gene in chronic atrophic gastritis (CAG and chronic superficial gastritis (CSG atients and to determine its possible function in the development of gastritis.
METHODS: Twenty-two outpatients diagnosed as CSG and 12 outpatients diagnosed as CAG were selected randomly. Ten cases of healthy individuals were selected as normal control group. In all cases, AQP3 gene expression of gastric mucosa was detected by fluorescence quantitative polymerase chain reaction (FQ-PCR.
RESULTS: The AQP3 gene expression was significantly higher in gastric mucosa of CSG and healthy individuals than that in CAG (P<0.01. However, there was no significant difference in the AQP3 gene expression between helicobacter pylori positive patients and helicobacter pylori negative patients (P>0.05.
CONCLUSIONS: AQP3 expression might play certain role in the occurrence and development of gastritis.
KEY WORDS: Aquaporin 3, chronic superficial gastritis, chronic atrophic gastritis.
Tatsu, Yoshimitsu; Ogura, Yasuharu; Yamazaki, Kouichi [Osaka Medical Coll., Takatsuki (Japan)] [and others
The relationship between serum PG I, PG II levels and extent of atrophic gastritis was examined. The subjects were 64 patients (male: 32, female: 32, 51.9 years old on average) with established diagnosis of either atrophic gastritis or normal. In the X-ray gastric examination, Fuji Computed Radiography (FCR) was used to obtain clear-cut images of the gastric area. Concerning the serum PG I level, patients in the group with atrophic gastritis showed lower levels than those of the people in the group with no atrophic change, but the variation was wide, and no definite tendency was seen in the relationship between the atrophic change and the serum PG I levels. Concerning the serum PG II level, as the atrophic change progresses, the serum PG II level tended to increase gradually. A significant reduction in the PG I/II ratio was seen in the group with atrophic changes (p<0.01) in comparison with the group with no atrophic changes, and the PG I/II value tended to decrease. In conclusion, as a relationship between the atrophic change and the serum PG levels had a wide variation, we considered it to be difficult to understand the presence and extent of the atrophic gastritis by measuring serum PG levels. (author).
The relationship between serum PG I, PG II levels and extent of atrophic gastritis was examined. The subjects were 64 patients (male: 32, female: 32, 51.9 years old on average) with established diagnosis of either atrophic gastritis or normal. In the X-ray gastric examination, Fuji Computed Radiography (FCR) was used to obtain clear-cut images of the gastric area. Concerning the serum PG I level, patients in the group with atrophic gastritis showed lower levels than those of the people in the group with no atrophic change, but the variation was wide, and no definite tendency was seen in the relationship between the atrophic change and the serum PG I levels. Concerning the serum PG II level, as the atrophic change progresses, the serum PG II level tended to increase gradually. A significant reduction in the PG I/II ratio was seen in the group with atrophic changes (p<0.01) in comparison with the group with no atrophic changes, and the PG I/II value tended to decrease. In conclusion, as a relationship between the atrophic change and the serum PG levels had a wide variation, we considered it to be difficult to understand the presence and extent of the atrophic gastritis by measuring serum PG levels. (author)
Bruno Annibale; Edith Lahner; Riccardo Negrini; Flavia Baccini; Cesare Bordi; Bruno Monarca; Gianfranco Delle Fave
AIM: To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.METHODS: A total of 140 atrophic body gastritis patients,diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori(H pylori) antibodies. Gastritis was assessed according to Sydney System.RESULTS: Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216,P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.CONCLUSION: The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG.
Doerthe Kuester; Michael Vieth; Ulrich Peitz; Stefan Kahl; Manfred Stolte; Albert Roessner; Ekkehard Weber; Peter Malfertheiner; Thomas Wex
AIM: To investigate a pathophysiological role of cathepsin W (CatW), a putative thiol-dependent cysteine protease,which is specifically expressed in cytotoxic lymphocytes,in different types of chronic inflammation of the gastric mucosa.METHODS: Gastric and duodenal biopsies of patients with Helicobacter pylori ( H pylori)-associated active gastritis ( Hp,n = 19), chemically induced reactive gastritis (CG, n = 17),autoimmune atrophic gastritis (AIG, n = 20), lymphocytic corpus gastritis (LG, n = 29), celiac disease (CD, n = 10),and corresponding controls (n = 24) were analyzed by immunohistochemistry for the expression of CatW and CD45. Furthermore, immunohistochemical double staining with anti-CD3 and anti-cathepsin was performed for the samples of AIG.RESULTS: Median values of CatW-expressing cells among CD45-positive immune cells were between 2% and 6% for normal gastric mucosa, CG, and LG, whereas the corresponding value was significantly increased for AIG (24.7%, P＜0.001) and significantly decreased for HP (0.7%, P＜0.05). Double staining with anti-CD3 and antiCatW antibodies revealed that ＞90% of CatW-expressing cells in gastric mucosa of AIG were T cells. Duodenal mucosa had significantly more CatW/CD45-positive cells than normal gastric mucosa (median: 17.8% vs 2%, P＜0.01).The corresponding proportion of CatW/CD45-positive cells was decreased in CD compared to duodenal mucosa (median: 2.1% vs 17.8%, P＜0.05).CONCLUSION: The opposite findings regarding the presence of CatW-positive cells in AIG (increase) and CD (decrease) reflects the different cellular composition of immune cells involved in the pathogenesis of these diseases.
Objective To explore the efficacy of tepronone and folic acid in the treatment of chronic atrophic gastritis(CAG) evaluated by the marking targeting biopsy(MTB).Methods A total of 224 H.pylori negative
Sitas, Frederick.; Forman, David; Dr. David Forman
There were three main aims to this thesis: 1. to test whether infection with Helicobacter pylori was related specifically to chronic atrophic gastritis (CAG), a precursor of gastric cancer; and to measure the specificity and sensitivity of Helicobacter pylori antibody markers for detecting H.pylori infection of the gastric mucosa; and CAG; 2. to measure the distribution of H.pylori in relation to sociodemographic, dietary and lifestyle characteristics in non-clinical ...
Full Text Available Introduction. We hereby describe the case of a young female patient who presented with pseudothrombotic microangiopathy, as well as pancytopenia accompanied by autoimmune atrophic gastritis. Case Presentation. A 36-year-old Caucasian woman presented to the emergency department with fatigue and dyspnea on minimal exertion. Physical examination was unremarkable except for pallor and noninjected conjunctiva. Laboratory tests revealed high LDH and low hemoglobin, white blood cells, platelets, and haptoglobin. The peripheral blood smear showed schistocytes suggestive of pseudothrombotic microangiopathy. Low cobalamin level and hyperhomocysteinemia were also detected. Autoimmune atrophic gastritis was confirmed by gastric biopsy and positive anti-intrinsic factor antibodies. Vitamin B12 supplements were given which led to rapid recovery and normalization of blood parameters. Conclusion. This case highlights the importance and serves as a reminder to clinicians to rule out cobalamin deficiency and autoimmune atrophic gastritis in patients presenting with a picture suggestive of thrombotic thrombocytopenic purpura and pancytopenia, which was completely reversible after appropriate replacement therapy without recurring to unnecessary and invasive procedures such as plasma exchange.
Li, Xiaozhou; Lin, Junxiu; Jia, Chunde; Wang, Rong
In this paper, we attempt to find a valid method to distinguish gastric cancer and atrophic gastritis. Auto-fluorescence and Raman spectroscopy of laser induced (514.5 nm and 488.0 nm) was measured. The serum spectrum is different between normal and cancer. Average value of diagnosis parameter for normal serum, red shift is less than 12 nm and Raman relative intensity of peak C by 514.5 nm excited is stronger than that of 488.0 nm. To gastric cancer, its red shift of average is bigger than 12 nm and relative intensity of Raman peak C by 514.5 nm excited is weaker than that by 488.0 nm. To atrophic gastritis, the distribution state of Raman peaks is similar with normal serum and auto-fluorescence spectrum's shape is similar to that of gastric cancer. Its average Raman peak red shift is bigger than 12 nm and the relative intensity of peak C by 514.5 excited is stronger than that of by 488.0. We considered it as a criterion and got an accuracy of 85.6% for diagnosis of gastric cancer compared with the result of clinical diagnosis.
Pittman, Meredith E; Voltaggio, Lysandra; Bhaijee, Feriyl; Robertson, Scott A; Montgomery, Elizabeth A
Autoimmune metaplastic atrophic gastritis (AMAG) is a significant risk factor for pernicious anemia and gastric neoplasia. Still, the histologic features of AMAG are frequently overlooked, especially in the early stages of the disease. The purpose of our study, therefore, was to catalogue the progression of histologic changes that precede the development of AMAG in affected individuals. Over a 2-year period (2012 to 2014), the diagnosis of AMAG was rendered on material from 113 patients seen at Johns Hopkins Hospital (∼1.8% of "in house" gastric biopsies). Prior gastric body biopsies had been performed on 54 (48%) patients in the cohort, and the majority of these specimens had also shown AMAG. Eighteen of the previous biopsies, however, carried a diagnosis other than AMAG: 13 inactive chronic gastritis, 2 acute Helicobacter pylori gastritis, and 1 each of eosinophilic gastritis, iron pill gastritis, and proton-pump inhibitor-like effect. Upon review of these 18 biopsies, the most common histologic findings were heavy full-thickness or deep lamina propria chronic inflammation (12), inflammatory destruction of oxyntic glands (12), metaplasia (intestinal, pyloric, or pancreatic acinar) (10), prominent lamina propria eosinophils (8), and parietal cell pseudohypertrophy (4). At least 2 of these features were present in the majority (13, 72%) of the biopsies. In addition, 7 (58%) of these patients were also found to have another autoimmune or inflammatory disorder before the diagnosis of AMAG. Although subtle, histologic features of developing AMAG are identifiable in routine gastric body biopsies. When metaplasia, full-thickness chronic inflammation, and/or oxyntic destruction are seen, a note suggesting laboratory testing and/or close clinical follow-up in this subset of patients may be warranted. PMID:26291507
Xue-Hui Shao; Yue-Ping Yang; Jie Dai; Jing-Fang Wu; Ai-Hua Bo
AIM: To study the effects of He-Ne laser irradiation on experimental chronic atrophic gastritis (CAG) in rats.METHODS: Sixty-three male adult Wistar rats were randomly divided into five groups including normal control group, model control group and three different dosages He-Ne laser groups. The chronic atrophic gastritis (CAG)model in rats was made by pouring medicine which was a kind of mixed liquor including 2% sodium salicylate and 30% alcohol down the throat for 8 wk to stimulate rat gastric mucosa, combining with irregular fasting and compulsive sporting as pathogenic factors; 3.36, 4.80, and 6.24J/cm2doses of He-Ne laser were used, respectively for three different treatment groups, once a day for 20 d. The pH value of diluted gastric acid was determined by acidimeter,the histopathological changes such as the inflammatory degrees in gastric mucosa, the morphology and structure of parietal cells were observed, and the thickness of mucosa was measured by micrometer under optical microscope.RESULTS: In model control group, the secretion of gastric acid was little, pathologic morphological changes in gastric mucosa such as thinner mucous, atrophic glands, notable inflammatory infiltration were found. After 3.36 J/cm2 dose of He-Ne laser treatment for 20 d, the secretion of gastric acid was increased (P＜0.05), the thickness of gastric mucosa was significantly thicker than that in model control group (P＜0.01), the gastric mucosal inflammation cells were decreased (P＜0.05). Morphology, structure and volume of the parietal cells all recuperated or were closed to normal.CONCLUSION: 3.36J/cm2 dose of He-Ne laser has a significant effect on CAG in rats.
Bao-Ying Fei; Bing Xia; Chang-Sheng Deng; Xiao-Qing Xia; Min Xie; J Bart A Crusius; A Salvador Pena
AIM: To investigate the association of TNF polymorphisms with chronic atrophic gastritis (CAG) and gastric adenocarcinoma in Chinese Han patients.METHODS: The TNFa-e 5 microsatellites and 3 RFLP sites were typed using PCR technique, followed by high-voltage denaturing PAGE with silver staining and restriction enzyme digestion respectively in specimens from 53 patients with CAG and 56 patients with gastric adenocarcinoma and 164 healthy controls. The PCR products were cloned and sequenced.RESULTS: The frequency of TNF-β Ncol*1/2 genotype was higher in patients with chronic atrophic gastritis than in healthy controls, but no significant difference was observed (60.38% vs 46.34%, P=0.076). The frequency of TNa10 allele was significantly higher in patients with chronic atrophic gastritis than in healthy controls (19.81% vs 11.89%,P=0.04). However, it did not relate to age, gender, atrophic degree or intestinal metaplasia in patients with chronic atrophic gastritis. The frequency of TNF-β Ncol*1/2 and d2/d6 genotypes were significantly higher in patients with gastric adenocarcinoma than in healthy individuals(P＞0.05).However, TNF-β Ncol*1/2 and d2/d6 genotypes did not relate to age, gender, grade of differentiation and clinicopathologic stage in patients with gastric adenocarcinoma. The frequency of TNFa6b5c1 haplotype homozygote was significantly lower in patients with gastric adenocarcinoma than in healthy controls (1.79% vs15.85%, P=0.006).CONCLUSION: TNFa10 allele may be a risk factor for chronic atrophic gastritis. TNF-β Ncol*1/2 and d2/d6 genotypes are associated with the susceptibility to gastric adenocarcinoma,whereas TNFa6b5c1 haplotype homozygote may contribute to the resistance against gastric adenocarcinoma.
Full Text Available Background/Aim. Autoimmune atrophic fundic gastritis induces the pernicious anemia (PA, as well as the changes in both epithelium and endocrine cells of gastric mucosa. The most important complications are: achlorhydria, hypergastrinemia, gastric cancer and enterochromaffin-like ( ECL carcinoid. The aim of this study was to examine ECL carcinoid histogenesis in A-gastritis associated with PA. Methods. During the period from 2000−2006, 65 patients with PA and 30 patients of the control group were examined. Histopathological examination was done in endoscopical biopsies of gastric mucosa fixed in 10% formaldehyde. Paraffin sections were stained with classic hematoxylin-eosin (HE; histochemical AB-PAS (pH 2.5, cytochemical argyrophilic Servier-Munger′s and immunocytochemical PAP methods for G cell identification and chromogranin A antibodies - specific marker for neuroendocrine ECL cells. Both G and ECL cells were counted per 20 fields, of surface 0.0245312 mm2 by a field. Basal gastrin serum levels were also examined by using radioimmunoassay (RIA method. The obtained results were statisticaly calculated by using Student΄s t test. Results. Marked antral G cell hyperplasia associated with corporal ECL hyperplasia was found. ECL cell hyperplasia was of simplex, linear, adenomatoid type to the pattern of intramucous ECL cell carcinoid. An average number of G cells was statistically significant in the patients with PA as compared to the control group (p < 0.05 as well as an average number of ECL cells. Conclusion. We concluded that antral G cell hyperplasia accompanied by gastrinemia induces ECL hyperplasia and ECL corporal carcinoid in A-gastritis and that their histogenesis develops trough simple, linear and adenomatoide hyperplasia. .
Full Text Available BACKGROUND: Helicobacter pylori is the most common human pathogen which causes chronic gastritis, leading to serious complications. The aim was to study the incidence of H. pylori infection and the risk factors associated with chronic atrophic gastritis using simple diagnostic procedures. MATERIALS AND METHODS: Biopsy samples were collected from 146 chronic atrophic gastritis patients. Rapid Urease Test (RUT and dark field microscopy were used to diagnose the presence of H. pylori infection. The prevalence rate of H. pylori infection in relation to age, sex, smoking and alcohol consumption was studied. RESULTS: 88 (60.27% cases were positive for RUT and also for the characteristic cork screw motility under dark field microscopy. Prevalence rate was high in younger age group and among female. We found no correlation of H. pylori infection with smoking and alcohol consumption. CONCLUSION: It has been found that H. pylori is a major causative agent for atrophic gastritis and RUT is a simple cost efficient diagnostic test for H. pylori. The association of H. pylori infection with age, sex, smoking and alcohol consumption is variable and requires further studies to establish any relationship.
Bin Lu; Ming-Tao Chen; Yi-Hong Fan; Yan Liu; Li-Na Meng
AIM: To investigate the effect of H pylori eradication on atrophic gastritis and intestinal metaplasia (IM).METHODS: Two hundred and fifty-nine patients with atrophic gastritis in the antrum were included in the study, 154 patients were selected for H pylori eradication therapy and the remaining 105 patients served as untreated group. Gastroscopy and biopsies were performed both at the beginning and at the end of a 3-year follow-up study. Gastritis was graded according to the updated Sydney system.RESULTS: One hundred and seventy-nine patients completed the follow-up, 92 of them received H pylori eradication therapy and the remaining 87 H pyloriinfected patients were in the untreated group. Chronic gastritis, active gastritis and the grade of atrophy significantly decreased in H pylori eradication group (P＜0.01). However, the grade of IM increased in H pylori -infected group (P＜0.05).CONCLUSION: H pylori eradication may improve gastric mucosal inflammation, atrophy and prevent the progression of IM.
Gao, Lei; Weck, Melanie Nicole; Rothenbacher, Dietrich; Brenner, Hermann
Abstract Background: Obesity and overweight have been positively related to gastroesophageal reflux disease (GERD). It has been suggested, that this relation is due to an increased gastric acid reflux which is caused by an enhanced intra-abdominal pressure. Aim: We aimed to assess potential interaction of the association between body mass index (BMI) and GERD by chronic atrophic gastritis (CAG) which goes along with reduced acid production. Methods: In the baseline examinat...
Guo-yang Sun; Jun-xia Wu; Jian-sheng Wu; Yu-ting Pan; Rong Jin
Objective:To investigate the expressions of caveolin-1,E-cadherin and β-catenin in gastric carcinoma,precancerous gastric and chronic non-atrophic gastritis tissues,and evaluate the correlation of these expressions with the development of gastric cancer.Methods:The expressions of caveolin-1,E-cadherin and β-catenin were detected by biotin-streptavidinperoxidase (SP) immunohistochemistry on 58 gastric cancer tissues,40 precancerous gastric tissues and 42 chronic non-atrophic gastritis tissues.The correlation between the expressions of caveolin-1,E-cadherin and β-catenin,and the clinicopathologic parameters of gastric cancer was analyzed retrospectively.Results:The positive rates of caveolin-1 and E-cadherin expressions in gastric carcinoma were significantly lower than precancerous gastric and chronic non-atrophic gastritis tissues (P＜0.01).An abnormal rate of β-catenin expression in gastric carcinoma was higher than precancerous gastric and chronic non-atrophic gastritis tissues (P＜0.01).Moreover,low expressions of caveolin-1,E-cadherin and β-catenin correlated with tumor size,depth of invasion,lymph node metastasis and TNM stage (P＜0.05).The positive rates of caveolin-1 and E-cadherin expressions decreased (P＜0.01),while an abnormal rate of β-catenin expression increased inversely,with the degree of atypical hyperplasia (P＜0.01).Caveolin-1 expression correlated positively with E-cadherin (r=0.41,P＜0.05).Caveolin-1 (r=-0.36,P＜0.05) and E-cadherin (r=-0.45,P＜0.05) expressions negatively correlated with abnormal β-catenin expression.Conclusion:These results suggested that dysregulated expressions of caveolin-1,E-cadherin and β-catenin correlated with the development of gastric cancer and its biological behavior.
Edith Lahner; Marco Intraligi; Massimo Buscema; Marco Centanni; Lucy Vannella; Enzo Grossi; Bruno Annibale
AIM: To investigate the role of artificial neural networks in predicting the presence of thyroid disease in atrophic body gastritis patients.METHODS: A dataset of 29 input variables of 253 atrophic body gastritis patients was applied to artificial neural networks (ANNs) using a data optimisation procedure (standard ANNs, T&T-IS protocol, TWIST protocol). The target variable was the presence of thyroid disease.RESULTS: Standard ANNs obtained a mean accuracy of 64.4% with a sensitivity of 69% and a specificity of 59.8% in recognizing atrophic body gastritis patients with thyroid disease. The optimization procedures (T&T-IS and TWIST protocol) improved the performance of the recognition task yielding a mean accuracy, sensitivity and specificity of 74.7% and 75.8%, 78.8% and 81.8%, and 70.5% and 69.9%, respectively. The increase of sensitivity of the TWIST protocol was statistically significant compared to T&T-IS.CONCLUSION: This study suggests that artificial neural networks may be taken into consideration as a potential clinical decision-support tool for identifying ABG patients at risk for harbouring an unknown thyroid disease and thus requiring diagnostic work-up of their thyroid status.
Full Text Available Abstract Background Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG. Methods A nested case-control study within the German population-based ESTHER cohort was conducted, including 533 CAG cases and 1054 controls. Polymorphisms in eleven DNA repair genes (APEX1, ERCC1, ERCC2/XPD, PARP1 and XRCC1, in CD3EAP/ASE-1 and PPP1R13L were analysed. Results No association was disclosed for any of the analysed polymorphisms. Nor did stratified analyses according to ages Conclusions The results of this large German case-control study do not reveal associations of DNA repair pathway polymorphisms and risk of CAG. On the basis of a large number of CAG cases, they do not support associations of DNA repair pathway SNPs with CAG risk, but suggest the need of larger studies to disclose or exclude potential weak associations, or of studies with full coverage of candidate genes.
Wang, Xu; Ling, Li; Li, Shanshan; Qin, Guiping; Cui, Wei; Li, Xiang; Ni, Hong
A meta-analysis was performed to assess the diagnostic value of gastrin-17 (G-17) for the early detection of chronic atrophic gastritis (CAG).An extensive literature search was performed, with the aim of selecting publications that reported the accuracy of G-17 in predicting CAG, in the following databases: PubMed, Science Direct, Web of Science, Chinese Biological Medicine, Chinese National Knowledge Infrastructure, Wanfang, and VIP. To assess the diagnostic value of G-17, the following statistics were estimated and described: sensitivity, specificity, diagnostic odds ratios (DOR), summary receiver operating characteristic curves, area under the curve (AUC), and 95% confidence intervals (CIs).Thirteen studies that met the inclusion criteria were included in this meta-analysis, comprising 894 patients and 1950 controls. The pooled sensitivity and specificity of these studies were 0.48 (95% CI: 0.45-0.51) and 0.79 (95% CI: 0.77-0.81), respectively. The DOR was 5.93 (95% CI: 2.93-11.99), and the AUC was 0.82.G-17 may have potential diagnostic value because it has good specificity and a moderate DOR and AUC for CAG. However, more studies are needed to improve the sensitivity of this diagnostic tool in the future. PMID:27149493
Full Text Available Previous in vitro and animal experiments have shown that sulforaphane, which is abundant in broccoli, inhibits Helicobacter pylori (H. pylori infection and blocks gastric tumor formation. This suggests that broccoli consumption prevents chronic atrophic gastritis (CAG introduced by H. pylori infection and, therefore, gastric cancer. For an epidemiological investigation of the relationship between the broccoli consumption and CAG, a cross-sectional study of 438 male employees, aged 39 to 60 years, of a Japanese steel company was conducted. CAG was serologically determined with serum cut-off values set at pepsinogen I < or = 70 ng/ml and a ratio of serum pepsinogen I/pepsinogen II < or = 3.0. Broccoli consumption (weekly frequency and diet were monitored by using a 31-item food frequency questionnaire. The prevalence of CAG among men who ate broccoli once or more weekly was twice as high as that among men who consumed a negligible amount (P < 0.05. Multiple logistic regression analysis indicated that broccoli consumption once or more weekly significantly increased the risk for CAG (odds ratio, 3.06; 95% confidence interval, 1.12-8.38; P < 0.05, after controlling for age, education, cigarette smoking, and alcohol consumption. The present study failed to show an expected association between frequent broccoli consumption and a low prevalence of CAG.
Jian-Min Si; Qian Cao; Min Gao
AIM: To investigate the growth hormone (GH) and growth hormone receptor (GHR) expression of and its clinical significance in patients with chronic atrophic gastritis (CAG).METHODS:A total of 90 cases were enrolled in the study.Thirty were healthy controls,the other 60 patients were divided into two groups according to the endoscopical and histological diagnosis.Blood samples were drawn in the morning (menarche did not occur during the blood extraction in female patients),gastric mucosa was obtained by endoscopy.Serum GH and gastrice mucosal GHR levels were measured using radioimmunoassay (RIA) and En Vinsion technique.RESULTS:The average GH level was 1.021±0.132μ/L in CAG patients,in controls it was 2.869 0.512μ/L.There was a significant difference between these two groups(P＜0.01).The positive rate of GHR in CAG patients was 10％,in controls the rate was 100％.There was a significant difference (P＜0.01).There was no significant change of GH level (3.176±0.421μ/L) in patients with gastric carcinoma compared with controls (P＞0.05).CONCLUSION:The study shows that levels of GH and GHR expression are low in CAG patients.CAG pathogenesis has a correlation with mucosal nutrient deficiency,decreased levels of GH and GHR have an adverse effect on the repair and regeneration of CAG.There is no significant change of GH in gastric carcinorma patients,GH dose not play a role in the pathogenesis of gastric cancer.
Wan-Sheng Ji; Zhi-Xing Gao; Kai-Chun Wu; Jun-Wen Qiu; Bing-Long Shi; Dai-Ming Fan
AIM: To demonstrate the effect of Hewei-Decoction(Decoction for regulating the stomach) on chronic atrophic gastritis (CAG) and eradication of Helicobacter pylori.METHODS: Ninety patients with CAG entering the investigation were divided into six differentiation syndromes, based on their major symptoms and signs.Hewei-Decoction was taken by all the patients orally for 4or 8 wk. The efficacy was assessed by both the composite accumulation of reduced scores of major symptoms and the eradication of H pylori.χ2 test was used to compare the efficacy between Hpylori-positive and negative cases,and to disclose the relationship between efficacy and eradication of H pylori.REStULTS: In patients with six different syndrome types,the efficacy of Hewei-Decoction was 91.67% (11/12),92.86% (13/14), 97.22% (35/36), 87.50% (14/16),75.00% (6/8), 75.00% (3/4) respectively. The rate of highly efficacious was 58.33% (7/12), 50.00% (7/14),77.78% (28/36), 62.50% (10/16), 12.50% (1/8) and25.00% (1/4), respectively. The total efficacy was 91.11%(82/90), and the rate of highly efficacious was 60.00%(54/90). The eradication rate of H pyloriwas 67.86%(38/56). The therapeutic effect of Hewei-Decoction was better in H pylori positive cases than that in Hpylori-negative cases with the total effect of 96.43% vs82.35% (P＜0.05).In 56 H pylori positive cases, the therapeutic effect was better in H pylori eradicated cases than that in H pyloriexistent cases with the total effect of 97.37% vs 72.22%(P＜0.01).CONCLUSION: Hewei-Decoction is effective in most cases of all the syndrome types. The results indicate that eradication of H pylori is one of the important mechanisms for alleviation of symptoms and signs. Also, the decoction is efficacious in H pylori-negative cases.
... Disease Organizations (PDF, 341 KB) Alternate Language URL Gastritis Page Content On this page: What is gastritis? ... Nutrition Points to Remember Clinical Trials What is gastritis? Gastritis is a condition in which the stomachlining— ...
Divided doses of 6,000 or 8,000 rad of x-ray were given to the gastric region of ICR/JCL female mice with immune atrophic gastritis produced by the injection with allogenic stomach antigen. The carcinogenic effect of x-rays for inducing gastric carcinoma was significantly increased by this method. Two points can be presented as its reason. First, the pyloric gland mucosa regenerating from injuries by immunization was exposed to the divided doses of x-rays. Second, the marked requirement of gastrin secretion attributable to severe injuries of parietal cell mass by immunization and local x-irradiation acted as a promoting factor on the induction of gastric carcinoma by x-ray for a long time through the trophic effects on the pyloric gland. (auth.)
Hou, Zheng-kun; Liu, Feng-bin; Li, Pei-wu; Zhuang, Kun-hai
To summarize Professor LIU Feng-bin's clinical experience and theoretical thoughts on chronic atrophic gastritis (CAG), the study group designed a retrospective study on his case series and expert interview. First of all, the data of CAG patients treated in the First Affiliated Hospital of Guangzhou University of Chinese Medicine between 2009 and 2013, e. g. herbs, diseases, syndrome type, prescription amount and number of herbs, was collected and processed. The statistical description and binary logistic regression were used to determined the syndrome type, initial basic remedy and modification. During the statistics, a complete and sub-group analysis was performed simultaneously. After the expert interview, the syndrome type and medication were finalized. As a result, a total of 228 CAG patients aged at (50.30 ± 10.18) were collected, including 151 males (66.23%). Of them, the TCM diagnosis and syndrome type were extracted from the information of 157 patients, including 115 cases with gastric stuffiness, 23 cases with gastric pain, 19 missing cases, 2 cases with spleen-stomach weakness syndrome, 57 cases with spleen deficiency and dampness-heat syndrome, 18 cases with spleen-stomach disharmony syndrome, 23 cases with syndrome of liver depression syndrome, 21 cases with liver qi invading stomach syndrome and 26 qi and yin deficiency syndrome, respectively. All of the 228 patients used totally 104 herbs, while the subgroups with 157 patients used 94 herbs. The most frequently used 15 herbs used in each groups were analyzed to determine the initial basic remedy and modification. Subsequently, based on the information of the sub-groups with 157 patients, with the syndrome type as the dependent variable, the logistic regression analysis was made on the most frequently used 32 herbs, in order to determined the modification in herbs for different syndrome types. After experts reviewed and modified, they believed the main causes of CAG were dietary irregularities
Wang, D Q; Ding, X P; Yin, S; Mao, Y D
The expression of interleukin-11 (IL-11) and its products STAT3 and phospho-STAT3 (p-STAT3) in patients with chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), and gastric cancer (GC) may provide insight into the diagnostic role of the IL-11/STAT3 signaling pathway in GC. Gastric mucosa specimens and serum samples were collected from 90 patients with CSG, CAG, and GC (30/group). The expression of IL-11, STAT3, and p-STAT3 was detected via immunohistochemistry and western blot. Additionally, serum levels of IL-11 were measured by enzyme-linked immunosorbent assay. For IL-11, 60% stained positive in CAG and 83.3% stained positive in GC, which were both higher than the value observed for CSG (33.3%). Moreover, the percent positive for IL-11 in GC was higher than that in CAG (P < 0.05). The percent positive for STAT3 in CAG (80%) and GC (83.3%) was higher than that in CSG (53.3%) (P < 0.05). Compared with CSG (36.7%), the percent positive for p-STAT3 in CAG (63.3%) and GC (86.7%) was also significantly higher. STAT3 expression was similar in GC and CAG, which was significantly higher than that in CSG. Expectedly, p-STAT3 expression gradually increased from CSG to CAG to GC. Furthermore, p-STAT3 levels were higher in GC tissues than in CAG (P < 0.01). Intriguingly, serum IL-11 levels gradually increased from CSG to CAG to GC, which coincided with disease severity. Together, these results suggest that the IL-11/STAT3 signaling pathway plays a critical role in human CAG, and may provide new targets to prevent and treat GC. PMID:27173233
El-Shafie, Kawther; Samir, Nafisa; Lakhtakia, Ritu; Davidson, Robin; Al-Waili, Ahmed; Al-Mamary, Muna; Al-Shafee, Mohammed
Vitamin B12 deficiency is common in developing countries and should be suspected in patients with unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised hyperpigmentation of the palmar and dorsal aspects of both hands of two months' duration. Other symptoms included numbness of the hands, anorexia, weight loss, dizziness, fatigability and a sore mouth and tongue. There was no evidence of hypocortisolaemia and a literature search revealed a possible B12 deficiency. The patient had low serum B12 levels and megaloblastic anaemia. An intrinsic factor antibody test was negative. A gastric biopsy revealed chronic gastritis. After B12 supplementation, the patient's symptoms resolved. Family physicians should familiarise themselves with atypical presentations of B12 deficiency. Many symptoms of this deficiency are reversible if detected and treated early. PMID:26357561
Full Text Available Vitamin B12 deficiency is common in developing countries and should be suspected in patients with unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised hyperpigmentation of the palmar and dorsal aspects of both hands of two months’ duration. Other symptoms included numbness of the hands, anorexia, weight loss, dizziness, fatigability and a sore mouth and tongue. There was no evidence of hypocortisolaemia and a literature search revealed a possible B12 deficiency. The patient had low serum B12 levels and megaloblastic anaemia. An intrinsic factor antibody test was negative. A gastric biopsy revealed chronic gastritis. After B12 supplementation, the patient’s symptoms resolved. Family physicians should familiarise themselves with atypical presentations of B12 deficiency. Many symptoms of this deficiency are reversible if detected and treated early.
Edith Lahner; Enzo Grossi; Marco Intraligi; Massimo Buscema; Vito D Corleto; Gianfranco Delle Fave; Bruno Annibale
AIM: To investigate whether ANNs and LDA could recognize patients with ABG in a database, containing only clinical and biochemical variables, of a pool of patients with and without ABG, by selecting the most predictive variables and by reducing input data to the minimum.METHODS: Data was collected from 350 consecutive outpatients (263 with ABG, 87 with non-atrophic gastritis and/or celiac disease [controls]). Structured questionnaires with 22 items (anagraphic, anamnestic, clinical, and biochemical data) were filled out for each patient. All patients underwent gastroscopy with biopsies. ANNs and LDA were applied to recognize patients with ABG.Experiment 1: random selection on 37 variables, experiment 2: optimization process on 30 variables, experiment 3:input data reduction on 8 variables, experiment 4: use of only clinical input data on 5 variables, and experiment 5:use of only serological variables.RESULTS: In experiment 1, overall accuracies of ANNs and LDA were 96.6% and 94.6%, respectively, for predicting patients with ABG. In experiment 2, ANNs and LDA reached an overall accuracy of 98.8% and 96.8%,respectively. In experiment 3, overall accuracy of ANNs was 98.4%. In experiment 4, overall accuracies of ANNs and LDA were, respectively, 91.3% and 88.6%. In experiment 5, overall accuracies of ANNs and LDA were,respectively, 97.7% and 94.5%.CONCLUSION: This preliminary study suggests that advanced statistical methods, not only ANNs, but also LDA,may contribute to better address bioptic sampling during gastroscopy in a subset of patients in whom ABG may be suspected on the basis of aspecific gastrointestinal symptoms or non-digestive disorders.
Zhao, Chunna; Li, Ping; Zhang, Lili; Wang, Bei; Xiao, Lili; Guo, Feng; Wei, Yueguang
The aim of this study is to discuss whether the methylation levels of Runx3 could be used as the early biomarker for predicting the prognosis in chronic atrophic gastritis (CAG) patients. A total of 200 subjects including 60 controls without CAG (Group 1), 70 patients with mild CAG (Group 2), and 70 patients with moderate and severe CAG (Group 3) were recruited for this cross-sectional investigation in the Department of Gastroenterology in Daqing Oilfield General Hospital from July 2013 to May 2014. The MlALDI-TOF-MS was used to measure the methylation levels of Runx3 in all of the subjects. Real-time quantitative reverse transcription polymerase chain reaction and western blotting were chosen to determine the expression levels of Runx3. The correlations between methylation levels of Runx3 among these CAG patients and their prognosis were shown by logistic regression models. The results demonstrated that the methylation levels of CpG13, CpG14, and CpG15 in Runx3 were higher in Group 3 than those in Groups 1 and 2 (P <0.05), whereas the mRNA and protein expression levels of Runx3 were lower in Group 3 than those in Groups 1 and 2 (P <0.05). There were significantly negative correlations between the methylation levels of Runx3 with its expression and the healing prognosis of CAG patients. In brief, this study proved that the hypermethylation modifications of CpG13, CpG14, and CpG15 in the promoter region of Runx3 could result in the down regulation of Runx3 expression to affect the prognosis of CAG. So the methylation levels of these CpG sites in Runx3 in the peripheral blood can be used as the biomarker for predicting the healing prognosis of CAG patients. PMID:27196446
Full Text Available BACKGROUND: The aim of this study was to investigate the interaction effects of pri-let-7a-1 rs10739971 with pepsinogen C (PGC and excision repair cross complementing group 6 (ERCC6 gene polymorphisms and its association with the risks of gastric cancer and atrophic gastritis. We hoped to identify miRNA polymorphism or a combination of several polymorphisms that could serve as biomarkers for predicting the risk of gastric cancer and its precancerous diseases. METHODS: Sequenom MassARRAY platform method was used to detect polymorphisms of pri-let-7a-1 rs10739971 G → A, PGC rs4711690 C → G, PGC rs6458238 G → A, PGC rs9471643 G → C, and ERCC6 rs1917799 in 471 gastric cancer patients, 645 atrophic gastritis patients and 717 controls. RESULTS: An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026; and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012 and PGC rs9471643 polymorphism (P interaction = 0.039 were observed for the risk of atrophic gastritis. CONCLUSION: The combination of pri-let-7a-1 rs10739971 polymorphism and ERCC6 and PGC polymorphisms could provide a greater prediction potential than a single polymorphism on its own. Large-scale studies and molecular mechanism research are needed to confirm our findings.
Niemelä, S.; Karttunen, T.; Kerola, T; Karttunen, R.
AIMS--To examine the course of lymphocytic gastritis and its relation to Helicobacter pylori (H pylori) infection in a 10 year follow up. METHODS--Ninety six patients were originally examined for dyspepsia in 1981. Gastroscopies with stepwise biopsies were performed on all the patients initially and after an interval of 10 years. RESULTS--Nine per cent of the patients (9/96) had features of lymphocytic gastritis in gastric biopsy at the first examination, and 12.5% (12/96) at the second exami...
Objective: To study the changing and its interaction of determining serum gastrin levels and Helicobacter pylori test during chronic atrophic gastritis into gastric cancer. Methods: RIA and 13C-urea breath test (13C-UBT) determined the Gs levels and Hp infection rate in 63 rate cases (first visit) patients, 48 cases (after one year return visit) patients, 35 cases (after three year return visit) patients and 30 cases (after five years return visit) patients with CAG 90 cases patients with gastric cancer (and different position) and 61 cases normal controls. They all were done study compared. Results: Serum Gs levels in 63 cases (first visit) patients, 48 cases (after one year return visit) patients, 35 cases (after three year return visit) patients and 30 cases (after five years return visit) patient with CAG were significantly higher (t=4.716, 5.218, 5.624, 6.179, 6.5772, all P0.05). Serum Gs levels in 90 cases with gastric cancer (and different position) was significantly higher (t=4.221, P<0.05; t=4.436, P<0.01) than 61 cases normal controls and the highest serum Gs level was found in cancer of cardia and fundus. And Hp infection rate was 88.8%. Conclusion: The early diagnosis on gastric cancer was very important by determining serum Gs and Hp infection rate. (authors)
Konturek, Peter C; Rembiasz, Kazimierz; Konturek, Stanislaw J; Stachura, Jerzy; Bielanski, Wladyslaw; Galuschka, K; Karcz, Danuta; Hahn, Eckhart G
H. pylori (Hp) -induced atrophic gastritis is a well-known risk factor for the development of gastric cancer. Whether Hp eradication can prevent or retard the progress of atrophy and metaplasia has been the topic of numerous studies but the subject remains controversial. Recently, the increased expression of ornithine decarboxylase (ODC), gastrin and cyclooxygenase (COX)-2 has been shown to be increased in premalignant lesions in gastric mucosa and to play an essential role in the malignant transformation. The aim of the study is to assess the effect of eradication therapy on atrophic gastritis and analyze the gene expression for ODC, COX-2 and gastrin in gastric mucosa after succesful eradication in patients with atrophic gastritis. Twenty patients with chronic atrophic gastritis including both corpus and antrum of the stomach were included in this study. Four antral mucosal biopsy specimens were obtained from antrum and four from corpus. The histopathologic evaluation of gastritis was based on Sydney classification of gastritis. All patients were Hp positive based on the [13C] urea breath test (UBT) and the presence of anti-Hp IgG and anti-CagA-antibodies detected by ELISA. The patients were then eradicated with triple therapy consiting of omeprazol (2 x 20 mg), amoxycillin (2 x 1 g) and clarithromycin (2 x 500 mg) for seven days and vitamin C 1 g/day for three months. In gastric mucosal samples obtained from the antrum and corpus before and after eradication, the mRNA expression for ODC, COX-2, and gastrin was assessed by reverse-transcription polymerase chain reaction (RT-PCR). In all patients the gastric secretory analysis was performed by measuring gastric acid output and serum gastrin levels. After triple therapy the successful eradication assessed by UBT was observed in 95% of patients. In 45% of patients the infection with CagA-positive Hp strain was observed. Three months after eradication a significant reduction in the gastric activity (neutrophilic
Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis.
Andrew R Moore
Full Text Available INTRODUCTION: Autoimmune chronic atrophic gastritis (CAG causes hypochlorhydria and hypergastrinaemia, which can lead to enterochromaffin-like (ECL cell hyperplasia and gastric neuroendocrine tumours (type 1 gastric NETs. Most behave indolently, but some larger tumours metastasise. Antrectomy, which removes the source of the hypergastrinaemia, usually causes tumour regression. Non-clinical and healthy-subject studies have shown that netazepide (YF476 is a potent, highly selective and orally-active gastrin/CCK-2 receptor antagonist. Also, it is effective in animal models of ECL-cell tumours induced by hypergastrinaemia. AIM: To assess the effect of netazepide on tumour biomarkers, number and size in patients with type I gastric NETs. METHODS: We studied 8 patients with multiple tumours and raised circulating gastrin and chromogranin A (CgA concentrations in an open trial of oral netazepide for 12 weeks, with follow-up 12 weeks later. At 0, 6, 12 and 24 weeks, we carried out gastroscopy, counted and measured tumours, and took biopsies to assess abundances of several ECL-cell constituents. At 0, 3, 6, 9, 12 and 24 weeks, we measured circulating gastrin and CgA and assessed safety and tolerability. RESULTS: Netazepide was safe and well tolerated. Abundances of CgA (p<0.05, histidine decarboxylase (p<0.05 and matrix metalloproteinase-7(p<0.10 were reduced at 6 and 12 weeks, but were raised again at follow-up. Likewise, plasma CgA was reduced at 3 weeks (p<0.01, remained so until 12 weeks, but was raised again at follow-up. Tumours were fewer and the size of the largest one was smaller (p<0.05 at 12 weeks, and remained so at follow-up. Serum gastrin was unaffected. CONCLUSION: The reduction in abundances, plasma CgA, and tumour number and size by netazepide show that type 1 NETs are gastrin-dependent tumours. Failure of netazepide to increase serum gastrin further is consistent with achlorhydria. Netazepide is a potential new treatment for type 1 NETs
Marija Milicevic; Snezana Bozanic; Nenad Solajic
Introduction： Chronic gastritis is inflammation of the gastric mucosa. It can be non-atrophic and atrophic. Atrophy isdefined as the loss of appropriate glands. It is frequently located in antral mucosa as consequence of Helicobacter pylori infectionand it is associated with intestinal gastric cancer. Goal： Describe histopathological and demographic characteristics of atrophicgastritis. Matherial and methods： We assessed the pathological reports of 100 patients with atrophic gastritis whose characteristicswere evaluated by using a semiquantitative scale of Sidney system of classification of gastritis. To assess the significance betweenthe incidence of various parametres we used ;~2 test. Results： We found that the difference in frequency of atrophic gastritis betweenmen and women was not statistically significant. The difference in distribution is statistically significant in favor of the antrum.Among patients who have atrophy with Helicobacterpylori infection and intestinal metaplasia and those who do not have metaplasia,it was found that the difference is highly statistically significant. Conclusion： The most frequent localisation of atrophic gastritis isantral mucosa. There is no difference between men and women in frequency of atrophic gastritis, while the aging is related with moreoften occurrence of atrophic gastritis.
苏同森; 刘文翠; 王均成
Objective To observe and analyze the clinical effect of amoxicilin and bismuth pectin bismuth in treatment of chronic atrophic gastritis. Methods According to the principle of voluntary patients,94 cases of chronic atrophic gastritis patients composition study group(47 cases)and control group(47 cases),the former treated with amoxicilin and bismuth pectin,the latter to be clarithromycin and coloidal bismuth pectin treatment,and compared between the two groups of patients with clinical curative effect observation.ResultsThe effective rate of the study group(93.6%)was significantly higher than that in the control group(76.6%),the difference was statisticaly significant(P<0.05,χ2=8.115),recurrence rate of the study group(6.4%) was lower than that of the control group(12.8%),the difference was statisticaly significant(P<0.05,χ2=7.361).Conclusion The effect of amoxicilin combined with bismuth pectin bismuth on chronic atrophic gastritis is significant,and the recurrence rate is low.%目的：观察与分析阿莫西林联合果胶铋在慢性萎缩性胃炎疾病治疗中的临床运用效果。方法依据患者自愿原则，将94例慢性萎缩性胃炎患者成分研究组（47例）与对照组（47例），前者予以阿莫西林+果胶铋治疗，后者予以克拉霉素+果胶铋治疗；观察与比较两组患者的临床疗效。结果研究组患者治疗后的有效率（93.6%）比对照组患者（76.6%）高，差异有统计学意义（P＜0.05，χ2=8.115）；研究组患者复发率（6.4%）低于对照组（12.8%），差异有统计学意义（P＜0.05，χ2=7.361）。结论采取阿莫西林联合果胶铋治疗慢性萎缩性胃炎，效果显著，且复发率低。
苏同森; 刘文翠; 王均成
目的：观察与分析阿莫西林联合果胶铋在慢性萎缩性胃炎疾病治疗中的临床运用效果。方法依据患者自愿原则，将94例慢性萎缩性胃炎患者成分研究组（47例）与对照组（47例），前者予以阿莫西林+果胶铋治疗，后者予以克拉霉素+果胶铋治疗；观察与比较两组患者的临床疗效。结果研究组患者治疗后的有效率（93.6%）比对照组患者（76.6%）高，差异有统计学意义（P＜0.05，χ2=8.115）；研究组患者复发率（6.4%）低于对照组（12.8%），差异有统计学意义（P＜0.05，χ2=7.361）。结论采取阿莫西林联合果胶铋治疗慢性萎缩性胃炎，效果显著，且复发率低。%Objective To observe and analyze the clinical effect of amoxicilin and bismuth pectin bismuth in treatment of chronic atrophic gastritis. Methods According to the principle of voluntary patients,94 cases of chronic atrophic gastritis patients composition study group(47 cases)and control group(47 cases),the former treated with amoxicilin and bismuth pectin,the latter to be clarithromycin and coloidal bismuth pectin treatment,and compared between the two groups of patients with clinical curative effect observation.ResultsThe effective rate of the study group(93.6%)was significantly higher than that in the control group(76.6%),the difference was statisticaly significant(P<0.05,χ2=8.115),recurrence rate of the study group(6.4%) was lower than that of the control group(12.8%),the difference was statisticaly significant(P<0.05,χ2=7.361).Conclusion The effect of amoxicilin combined with bismuth pectin bismuth on chronic atrophic gastritis is significant,and the recurrence rate is low.
César, Ana Cristina Gobbo; Calmon, Marília de Freitas; Cury, Patrícia Maluf; Caetano, Alaor; Borim, Aldenis Albaneze; Silva, Ana Elizabete
AIM: To investigate the occurrence of chromosome 3, 7, 8, 9, and 17 aneuploidies, TP53 gene deletion and p53 protein expression in chronic gastritis, atrophic gastritis and gastric ulcer, and their association with H pylori infection.
陈吉; 崔宏; 高美丽; 崔琴
目的:探讨凋亡抑制蛋白Livin和细胞周期蛋白D1(CyclinDI)在慢性萎缩性胃炎(chronicatrophic gastritis,CAG)伴肠化癌变过程中的表达及其相关性.方法:应用免疫组织化学染色S-P法检测Livin和CyclinD1在30例慢性浅表性胃炎(chronicsuperficial gastritis,CSG)、35例CAG非肠化、35例CAG伴肠化、30例胃癌组织中的表达,并同时研究二者在CAG伴肠化癌变中表达的相关性.结果:在CSG、CAG非肠化、CAG伴肠化、胃癌中Livin、CyclinD1的阳性表达率分别为:0％、10％; 28.57％、14.29％; 45.71％、37.14％; 66.67％、53.33％,二者在CAG(非肠化)和CSG对比均有统计学意义(P＜0.05)；CAG(伴肠化)与CAG(非肠化)相比,CyclinD1的阳性表达率有统计学意义(P＜0.05); Livin和CyclinD1在CAG伴肠化、胃癌组织中表达呈正相关.结论:Livin、CyclinD1蛋白在CAG(伴肠化)和胃癌组织中表达呈上调状态,且CAG(伴肠化)和胃癌组织间无显著差异,二者表达一致,提示CAG(伴肠化)已具有癌变的分子生物学特征.二者在胃癌的发生、发展中起协同作用,对其进行联合检测将有助于胃癌的早期诊断.%AIM: To investigate the expression of livin and cyclinDl in chronic atrophic gastritis with intestinal metaplasia.METHODS: Immunohistochemistry was used to examine the expression of livin and cyclin Dl in 30 cases of chronic superficial gastritis, 35 cases of atrophic gastritis without intestinal metaplasia, 35 cases of atrophic gastritis with intestinal metaplasia, and 30 cases of gastric carcinoma. We also explored the correlation between livin and cyclin Dl expression in chronic atrophic gastritis and gastric carcinoma.RESULTS: The positive rates of livin expression in the specimens of chronic superficial gastritis,atrophic gastritis without intestinal metaplasia, atrophic gastritis with intestinal metaplasia, and gastric carcinoma were 0%, 28.57%, 45.71% and 66.67%, respectively, and the corresponding rates for
Inoue, Izumi; Kato, Jun; Yoshimura, Noriko; Maeda, Yoshimasa; Moribata, Kosaku; Shingaki, Naoki; Deguchi, Hisanobu; Enomoto, Shotaro; Maekita, Takao; UEDA, KAZUKI; Iguchi, Mikitaka; Tamai, Hideyuki; FUJISHIRO, MITSUHIRO; Yamamichi, Nobutake; Takeshita, Tatsuya
In a previous population-based case-control study, we demonstrated an elevated risk of colorectal neoplasia with Helicobacter pylori (H. pylori) infection. The present study investigated the effects of H. pylori-associated chronic gastritis on the development of colorectal neoplasia by analyzing the recurrence of colorectal neoplasia subsequent to endoscopic resection. Ninety-nine patients who had undergone endoscopic resection of colorectal neoplasia were monitored under colonoscopy, and the...
[Objective] Atrophic gastritis is a disease with intestinal metaplasia, and reveals that human immune system (cells, body fluids, partial immunity) is in a low state. "Spleen is a defense banier to pathogenic qi," "if spleen function maintains normal all the time, human body will not be ill," that reveals the immune role of the spleen. In modern medicine, spleen is regarded as immune response and immune material base, one of the barriers of the human immune system. Because proteomics is not anatomical concept of organs and tissues etc., but involves in certain aspects' alteration in biochemistry and internal relationship of disease processes. These physiological and pathological viewpoints are in coincident with TCM holism. From the angle of immunity micro-molecule proteome, atrophic gastritis spleen-qi deficiency substance will be elaborated.%萎缩性胃炎(AG)是人体整体免疫力(细胞、体液、局部免疫)低下,多种因素长期作用而表现胃局部、常伴肠化的病症.“脾为之卫”、“四季脾旺不受邪”,表现脾的免疫防卫作用,现代医学也认为脾是免疫应答和产生免疫效应物质的重要基地,人体免疫系统的屏障之一.由于蛋白质组学的研究不是从器官组织的解剖学定位出发,强调生物化学某一环节的改变和疾病过程的内在联系,与中医学整体的生理病理观有更多的切合点,本文旨在从免疫小分子蛋白质组表达规律的角度观察与AG脾气虚证的相关性.
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis.
Rubio, Carlos A
The mucosa of the esophagus, the stomach, the small intestine, the large intestine and rectum are unremittingly challenged by adverse micro-environmental factors, such as ingested pathogenic and non-pathogenic bacteria, and harsh secretions with digestive properties with disparate pH, as well as bacteria and secretions from upstream GI organs. Despite the apparently inauspicious mixture of secretions and bacteria, the normal GI mucosa retains a healthy state of cell renewal. To by-pass the tough microenvironment, the epithelia of the GI react by speeding-up cell exfoliation, by increasing peristalsis, eliminating bacteria through secretion of plasma cell-immunoglobulins and by increasing production of natural antibacterial enzymes (lysozyme) and host defense peptides (defensin-5). Lysozyme was recently found up-regulated in Barrett's esophagitis, in chronic gastritis, in gluten-induced atrophic duodenitis (celiac disease), in collagenous colitis, in lymphocytic colitis and in Crohn's colitis. This up-regulation is a response directed towards the special types of bacteria thriving in the microenvironment in each of the aforementioned clinical inflammatory maladies. The purpose of that up-regulation is to protect the mucosa affected by the ongoing chronic inflammation. Bacterial antibiotic resistance continues to exhaust our supply of effective antibiotics. The future challenge is how to solve the increasing menace of bacterial resistance to anti-bacterial drugs. Further research on natural anti-bacterial enzymes such as lysozyme, appears mandatory. PMID:26637845
Zhang, Jialing; Huang, Kangbai; Zhong, Guoxin; Huang, Yong; Li, Suhe; Qu, Shanshan; Zhang, Jiping
Acupuncture has been used to treat chronic atrophic gastritis (CAG) in traditional Chinese medicine (TCM) for centuries. In this study, we evaluated the effect of acupuncture at Zusanli (ST36), Zhongwan (CV12), and Pishu (BL20) acupoints on weight changes of rats, histological changes of gastric glands, and expressions changes of nuclear factor-kappa B (NF-κB) p65, microRNA- (miR-) 155, miR-21, and miR-146a in CAG rats induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) combined with irregular diet. Consequently, we found that acupuncture treatment elevated body weight of rats significantly when compared to the model group. By observing histological changes, we found that the acupuncture group showed better improvement of gastric mucosa injury than the model group. Our results also demonstrated upregulation of NF-κB p65, miR-155, and miR-21 in gastric tissue of CAG rats and a positive correlation between miR-155 and miR-21. Relatively, expression of miR-146a was downregulated and negative correlation relationships between miR-146a and miR-155/miR-21 in CAG rats were observed. Additionally, expressions of NF-κB p65, miR-155, and miR-21 were downregulated and miR-146a was upregulated after acupuncture treatment. Taken together, our data imply that acupuncture can downregulate NF-κB p65, miR-155, and miR-21 and upregulate miR-146a expression in CAG rats. NF-κB p65, miR-155, miR-21, and miR-146a may play important roles in therapeutic effect of acupuncture in treating CAG. PMID:27293468
Impact on Gastric Mucosa Histopathology of Atrophic Gastritis by Traditional Chinese Drug Prescription Based on Asthenia Syndrome Depression Syndrome Poison Syndrome Static Blood Syndrome%从虚郁毒瘀立法组方对萎缩性胃炎鼠模型胃黏膜病理的影响
王常松; 王启国; 俞杰; 闵莉; 吴银盘
Objective: To observe intervention of the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome on gastric mucosa histopathology, of atrophic gastritis.Methods: Alcohol, deoxysodium cholate, ammonia solution, indometacin and disorder between feeding and fasting were used to build the mode]of atrophic gastritis, which were treated respectively by the high-dose, mid-dose, low-dos traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static Blood syndrome, and their therapeutic effects were appreciated by the degree of gastric mucosa inflammation and atrophy, thickness of gastric mucosa.Results: The degree of gastric mucosa inflammation and atrophy, thickness of gastric mucosa became better by means of the model of atrophic gastritis treated by mid-dose of the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome.Conclusions: The therapeutic effect of atrophic gastritis treated by the traditional Chinese drug prescription based on asthenia syndrome, depression syndrome, poison syndrome, static blood syndrome is reliable.%目的:观测从虚郁毒瘀立法组方对萎缩性胃炎鼠模型胃黏膜病理形态的干预作用.方法:采用乙醇+去氧胆酸钠+氨水+吲哚美辛+饥饱失常综合法复制萎缩性胃炎鼠模型,并用从虚郁毒瘀立法组方低、中、高剂量分别进行干预,从对胃黏膜炎症及萎缩分度、胃黏膜厚度方面的影响观测各剂量组的治疗效果.结果:从虚郁毒瘀立法组方中剂量组可明显改善萎缩性鼠模型胃黏膜的炎症和萎缩程度,以及胃黏膜的厚度.结论:从虚郁毒瘀立法组方治疗萎缩性胃炎疗效可靠.
唐旭东; 张翠萍; 张琪; 赵坤; 孙向红; 田字彬
目的 建立较理想的幽门螺杆菌(Hp)感染慢性萎缩性胃炎(CAG)大鼠模型.方法 雄性Wistar大鼠60只,随机分为Hp感染及水杨酸钠乙醇灌胃组(模型组)、正常对照组(A组)、单纯Hp感染组(B组)、单纯水杨酸钠乙醇灌胃组(C组).采用灌胃接种Hp菌株(SSI)及20 g/L水杨酸钠与体积分数0.60的乙醇混合溶液方法建立Hp感染CAG模型,共14周.检测各组Hp定植情况,并对胃窦黏膜病理组织学各项指标进行评分.结果 模型组及B组胃窦黏膜均有Hp定植.模型组胃窦黏膜变薄,固有层腺体中度减少伴有中度慢性活动性炎症.模型组慢性炎症评分、活动性炎症评分及固有腺减少评分均明显高于A、B组(x2=47.632～48.276,q=6.514～11.191,P＜0.01),而与C组比较,差异无显著性(P＞0.05).结论 采用Hp感染大鼠及水杨酸钠与乙醇混合溶液灌胃的方法建立Hp感染CAG大鼠模型,其病因、病理变化与人类CAG病变相似,可作为研究Hp感染CAG发病机制及药物干预治疗CAG较合适的动物模型.%Objective To create a more ideal rat model of chronic atrophic gastritis 0. 05), Conclusion The causes of disease and pathological changes in rat models of CAG that created by Hp infection combined with mixed solution of sodium salicylate and ethanol are similar to that found in human subjects. This can be used as a suitable animal model in researching the mechanism of CAG due to Hp infection and drug therapy for this condition.
目的：探讨胃蛋白酶原Ⅰ(PGⅠ)联合胃泌素-17(G-17)检测对慢性萎缩性胃炎发病部位及胃癌进展时期的预测价值。方法选择本院收治的慢性萎缩性胃炎患者33例、胃癌患者35例作为研究对象，进行PGⅠ、PGⅡ和G-17检测，比较并分析PGⅠ、PGⅡ及G-17水平的变化情况。结果慢性萎缩性胃炎组PGⅠ和G-17水平高于胃癌组，差异有统计学意义(P<0.05)，胃窦部组的PGⅠ水平高于胃体部组和全胃弥漫组，差异有统计学意义(P<0.05)，胃体部组的G-17水平高于全胃弥漫组和胃窦部组，差异有统计学意义(P<0.05)，早期胃癌或原位癌的PGⅠ和G-17水平显著高于进展期胃癌，差异有统计学意义(P<0.05)。结论胃窦部发病为主的慢性萎缩性胃炎其G-17显著下降，胃体部或全胃病变者PGⅠ的下降更加明显，进展期胃癌者PGⅠ水平更低而G-17水平更高。%Objective To investigate the prediction vaule of pepsinogenⅠ combined with gastrin-17 in lesion location of chronic atrophic gastritis and the period of gastric cancer progression. Methods 33 cases with chronic atrophic gas-tritis and 35 cases in the different period of gastric cancer in our hospital were selected as research objects.All these participants were detected by pegsinogenⅠ,pegsinogenII and gastrin-17.The level of pegsinogenⅠ,pegsinogenII and gastrin-17 were compared and analyzed. Results The level of pepsinogens I and gastrin-17 in chronic atrophic gastri-tis group were higher than that in gastric cancer group,with statistical difference(P<0.05).Pepsinogen I level in the gas-tric antrum of chronic atrophic gastritis was higher than that in the gastric body and the total diffuse,with statistical dif-ference (P<0.05),the gastrin-17 level in the gastric body was higher than that in the total diffuse and in the gastric antrum,with statistical difference (P<0.05).Pepsinogen I and gastrin-17 lever of early gastric cancer and carcinoma
Sipponen, Pentti; Maaroos, Heidi-Ingrid
Abstract Prevalence of chronic gastritis has markedly declined in developed populations during the past decades. However, chronic gastritis is still one of the most common serious pandemic infections with such severe killing sequelae as peptic ulcer or gastric cancer. Globally, on average, even more than half of people may have a chronic gastritis at present. Helicobacter pylori infection in childhood is the main cause of chronic gastritis, which microbial origin is the key for the understand...
Du, Yiqi; Bai, Yu; Xie, Pei; Fang, Jingyuan; Wang, Xiaozhong; Hou, Xiaohua; TIAN, DEAN; Wang, Chengdang; Liu, Yandi; Sha, Weihong; Wang, Bangmao; Li, Yanqing; Zhang, Guoliang; Li, Yan; Shi, Ruihua
Background Chronic gastritis is one of the most common findings at upper endoscopy in the general population, and chronic atrophic gastritis is epidemiologically associated with the occurrence of gastric cancer. However, the current status of diagnosis and treatment of chronic gastritis in China is unclear. Methods A multi-center national study was performed; all patients who underwent diagnostic upper endoscopy for evaluation of gastrointestinal symptoms from 33 centers were enrolled. Data i...
刘洁; 刘琳; 李慧臻
目的:基于定标活检技术评价半夏泻心汤对慢性萎缩性胃炎(寒热错杂证)的疗效.方法:符合诊断标准的病例30例,随机分为治疗组(半夏泻心汤组)和对照组(胃复春组),3个月为1个疗程.观察治疗前后两组的临床症状,并在定标活检下观察胃镜下病理改变情况.结果:临床症状:两组在改善症状方面均有效,治疗组优于对照组(P＜0.05),内镜疗效无显著性差异(P＞0.05).结论:半夏泻心汤可显著改善慢性萎缩性胃炎(寒热错杂证)的临床症状.%Objective: To make the curative effect evaluation of Banxia Xiexin Decoction on chronic atrophic gastritis (cold -heat complicated syndrome)based on the calibration biopsy technique. Methods:30 cases met the diagnostic criteria were randomly divided into the treatment group (Banxia Xiexin Decoction group) and the control group ( Weifuchun group) ,3 months was a treatment course. Before and after treatment the clinical symptoms were observed, and pathological changes were observed under gas-troscope biopsy in calibration. Results: Clinical symptoms: two groups in improving the symptoms were valid, the treatment group was better than control group (P 0. 05 ) . Conclusion: Banxia Xiexin Decoction can significantly improve chronic atrophic gastritis(cold-heat complicated syndrome) clinical symptoms.
Cirurgia laparoscópica no diagnóstico de gastrite crônica atrófica seguida de tratamento clínico em cadela: relato de caso Laparoscopic surgery in the diagnosis of atrophic gastritis in a dog followed by clinical treatment: case report
Full Text Available Descrevem-se o diagnóstico e o tratamento de um caso de gastrite atrófica crônica, em uma cadela sem raça definida, de dois anos de idade. A paciente apresentava como principal sintomatologia vômito crônico. O hemograma, a urinálise e as avaliações bioquímicas séricas não revelaram alterações significativas. Os exames radiológicos e ultra-sonográficos abdominais também não foram sugestivos de alterações. Realizaram-se inspeção da cavidade peritoneal, gastrotomia, gastroscopia, gastrectomia para biopsia e gastrorrafia intracorpórea videolaparoscópicas. Constatou-se ausência de rugosidades estomacais. Ao exame histológico, observou-se atrofia das células principais e parietais da mucosa gástrica. O quadro clínico permitiu o diagnóstico de gastrite crônica atrófica. O animal foi medicado com terapia imunossupressora e apresentou remissão completa dos sinais clínicos.This report describes a case of chronic atrophic gastritis. A two-year-old female mongrel dog showed chronic emesis. The complete blood count serum chemistry and urinalysis values were within the normal limits. Radiographs revealed no alterations. Abdominal evaluation, gastrotomy, gastroscopy, gastrectomy and intracorporeal stomach suture were done by laparoscopic approach. Absence of gastric villous was noticed through laparoscopic biopsy. The microscopic analysis reveled parietal and principal gastric mucosal cells atrophy, which, associated with clinical signs, allowed the chronic atrophic gastritis diagnosis. The animal was treated and clinical signs complete remission was observed.
Erosive gastritis is a well-defined radiologic and endoscopic entity. It is one of the common causes of upper gastrointestinal bleeding, yet it is seldom diagnosed and often confused with a number of other diseases. This communication re-emphasizes the characteristic endoscopic and radiologic features of erosive gastritis and its differential diagnosis. Two representative cases are reported. (orig.)
Cell proliferation of human gastric mucosa was studied in the cases of chronic gastritis using the in vitro incubation method of 3H-thymidine autoradiography. The study was carried out using the material consisted of 92 biopsy specimens and 83 stomachs diagnosed as carcinoma, peptic ulcer, duodenal ulcer and chronic gastritis. The labelling index was expressed in a percentage of labelled cells in ratio to the total number of epithelial cells. In the normal gastric mucosae, 3H-TdR labeled cells were in the neck region of the gastric gland, but did not appear in the surface epithelium. Higher incorporation of 3H-TdR was observed in the lower part of the neck region of the glands. The average indices, both labeling and mitotic, were generally higher in the antrum than in the pylorus in the cases of chronic gastritis and also higher than normal mucosae. Superficial gastritis showed many labeled cells which were located in the neck region and foveolae. Simple gastitis showed scattered labeled cells in various parts of mucosae. In atrophic and atrophic hyperplastic gastritis, labeled cells were found in the neck and fobeolae of the gastric glands. Metaplastic gastritis showed labeled cells especially in the neck regions. The average labeling index is higher in simple chronic gastritis than in other superficial gastritis, atrophic, atrophic hyperplastic and metaplastic gastritis. Information concerned with cell renewal and proliferation is important for further understanding of the development of disease. (J.P.N.)
宗湘裕; 王万卷; 刘宝珍; 杜长海; 赵景成
Objective It is to study the relationship between H.pylori infection and pathological grade in chronic atrophic gastritis with syndrome types of TCM.Methods 106 cases of patients with chronic atrophic gastritis diagnosed by gastroscopy and pathology were divided into five groups according to TCM syndrome differentiation: spleen-stomach deficiency group, spleen-stomach dampness-heat group, stomach Yin deficiency group,liver and stomach disharmony group and blood stagna-tion of stomach collaterals group.The relationship of distribution of syndrome types of TCM with H.pylori infection, atrophy, intestinal metaplasia,dysplasia degree was observed and compared.Results Chronic atrophic gastritis in proportion from high to low were spleen and stomach deficiency type, dampness-heat of spleen and stomachtype, liver and stomach disharmony type,stomach Yin deficiency type and blood stagnation of stomach collaterals type.The total infection rates in proportion from high to low were dampness-heat of spleen and stomach type,liver and stomach disharmony type, blood stagnation of stomach collaterals type, spleen and stomach deficiency type, stomach Yin deficiency type, and the total infection rate was 58.49%. Mild atrophy of liver stomach disharmony of the ratio was higher.The proportion of spleen stomach damp heat syndrome, blood stasis syndrome of stomach meridian,stomach Yin deficiency syndrome in severe atrophy degree were higher than that of spleen and stomach weakness, liver and stomach disharmony type.No significant difference in proportion of mild to moderate atrophy, intestinal metaplasia among the five groups was found.The proportion of mild dysplasia was higher in spleen stomach damp heat syndrome, blood stasis syndrome than that in spleen and stomach deficiency syndrome,syndrome of incoordination between liv-er and stomach, deficiency of stomach Yin syndrome.The degree of gastric precancerous lesions of stomach meridian in the blood stasis was the highest, followed by
Forstner, G. G.; Bogoch, A.
Seven illustrative cases of gastritis of the herniated stomach in patients with sliding esophageal hiatus hernia are reported. Five had superficial gastritis (three mild, one moderate and one severe); two had atrophic gastritis. Gastritis was present in two patients whose mucosa appeared normal at esophagoscopy. Interstitial hemorrhage into the lamina propria was present in four of the seven biopsy specimens. The possibility that interstitial hemorrhage may be related to the development of gastric erosions is considered. The pathogenesis of this form of gastritis is discussed. ImagesFig. 1Fig. 2Fig. 3 PMID:13958838
Kim, Yeon Soo; Lee, Hye Kyung; Kim, Jong Ok; Lee, Seung Woo; Kang, Sang Beom; Nam, Soon Woo; Lee, Dong Soo
A 46-year-old man had chronic granulomatous gastritis characterized by giant gastric folds with noncaseating epithelioid granulomas including giant cells in the corpus. No definite etiologic factors were detected. Histology and the rapid urease test indicated that H. pylori was present in both the antrum and corpus. The granulomatous gastritis with giant gastric folds improved after H. pylori eradication. This case suggests an association between isolated granulomatous gastritis and H. pylori...
George K Anagnostopoulos; Krish Ragunath; Anthony Shonde; Christopher J Hawkey; Kenshi Yao
Endoscopic visualisation of gastric atrophy is usually not feasible with conventional endoscopy. Magnifying endoscopy is helpful to analyze the subepithelial microvascular architecture as well as the mucosal surface microstructure without tissue biopsy. Using this technique we were able to describe the normal gastric microvasculature pattern and we also identified characteristic patterns in two cases of autoimmune atrophic gastritis.
Futagami, S; Takahashi, H.; Norose, Y; Kobayashi, M.
Background—Helicobacter pylori urease is a major target for immune responses among various bacterial components in H pylori infected patients. Aims—To analyse the relation between systemic and local humoral immune responses to H pylori urease and grades of chronic gastritis. Patients—Seventy five patients with chronic gastritis associated with H pylori infection were classified into three groups (grade I, superficial gastritis; II, atrophic gastritis, quiescent; or III,...
Radioimmunoassay of gastrin level in the blood was performed in 20 controls, 12 patients with duodenal ulcer, 13 patients with atrophic gastritis and 14 patients with Addison-Biermer's disease. Gastrin level in the serum of the patients with duodenal ulcer did not differ significantly from that of controls. In atrophic gastritis and particularly in Addison-Biermer's disease gastrin level was found to be several times higher. This is probably a result of chronic gastrin secretion stimulation which is normally inhibited by gastric juice. (author)
胡品津; 曾志荣; 陈旻湖; 陈为; 彭晓忠; 林汉良
目的明确根除幽门螺杆菌(Helicobacter pylori，Hp)对萎缩性胃炎的形成和逆转的影响。方法 110只2级C57BL/6小鼠随机分为实验组(60只)和对照组(50只)。实验组动物感染Hp后又随机分为A、B两组，并分别于感染后6个月和12个月根除Hp。采用悉尼系统、免疫组化及流式细胞术比较根除前后鼠腺胃黏膜组织学和细胞动力学。结果 (1)接受根除治疗的动物Hp检查均为阴性。根除Hp可明显改善A、B两组动物腺胃的慢性活动性炎症。A组动物在各时间点均未观察到萎缩的形成，B组动物于感染Hp后12个月腺胃出现萎缩性改变，根除Hp后3个月、6个月萎缩未有明显减轻。(2)根除Hp可明显改善腺胃黏膜细胞动力学，根除后6个月时S期细胞百分比(S％)、增殖指数(PI)和胃黏膜上皮细胞Brdu标记指数(LI)与同期对照组动物比较差异无显著性(P值均>0．05)。结论本研究表明，早期根除Hp可预防萎缩性胃炎的形成，对已形成的萎缩性胃炎无逆转作用，但可防止病变进一步发展。%Objective To investigate the effect of eradication of Helicobacter pylori (H. pylori) on de-velopment and reversion of atrophic gastritis by animal study. Methods One hundred and ten of two-grade C57BL/6 female mice were randomly divided into experimental group (60 mice) and control group (50 mice).The mice in experimental group were infected with SS1 H. pylori strain, and then randomly subdivided into group A and group B, 30 mice in each group. Group A and group B received a mouse equivalent dose of stan-dard bismuth triple therapy 6 and 12 months after infection respectively, 10 mice were subsequently sacrificed before the therapy, and 3 and 6 months after completion of the therapy, respectively, in each group.Histopathological features of the glandular stomach were graded as definiens in the Sydney System, and kinetic changes of mucosal epithelial cells of the glandular stomach
@@ LU Zheng, male, born in 1938, a chief physician in Zhejiang Provincial Academy of TCM, is one of the second national batch of supervisors in the inheritance work of academic experiences of veteran TCM experts. He has his unique ideas on the TCM theories of toxicology, spleen and stomach, stimulation of kidney-qi, essential-qi, and kidneyessence. In clinical practice, he excels in treating diseases of internal medicine, gynecological and pediatric diseases, and the various stubborn and miscellaneous diseases.
Sutton, P.; Wilson, J.; Genta, R; Torrey, D; Savinainen, A; Pappo, J; Lee, A.
BACKGROUND—The importance of host factors in helicobacter induced gastritis has been shown in animal models. Infection of most mouse strains with Helicobacter felis results in a functional atrophic gastritis, while other strains remain gastritis free. AIMS—To investigate these host factors further by using genetic crosses of responder and non-responder mice. METHODS—F1 hybrids of the non-responder CBA/Ca strain and three strains of mice known to develop H felis induced gastritis were infected...
唐梅文; 王伟; 李桂贤; 岳小红; 陈国忠; 邓嫦
Objective To investigate the effects of Modified Qifan Weitong Granules(QWG) on pepsin content and heat shock protein 70(HSP70) expression in the gastric mucosa of rats with chronic atrophic gastritis(CAG).Methods CAG rat models were established by means of N-methyl-N'-nitro-N-nitrosoguanidine(MNNG), and the effect of QWG on relative indexes was observed and compared with that of Weifuchun Granules. Results Compared with the model group, the atrophy and intestinal metaplasia of gastric mucosa were relieved in large-and medium-dosage QWG groups and in Weifuchun Granules group, and the pepsin content and HSP70 expression were increased in large-, medium-and small-dosage QWG groups and in Weifuchun Granules group, the difference being significant(P＜ 0.01). Compared with Weifuchun Granules group, pepsin content and HSP70 expression in large-dosage QWG group were increased with statistical significance(P ＜ 0.05). Conclusion The mechanism of QWG in preventing and treating CAG may be related with prevention of gastric mucosa through increasing pepsin con tent and HSP70 expression.%目的 探讨加味七方胃痛颗粒对慢性萎缩性胃炎(CAC)模型大鼠胃黏膜组织中胃蛋白酶含量及热休克蛋白70(HSP70)表达的影响.方法 采用化学致癌物N-甲基-N'-硝基-N-亚硝基胍(MNNG)建立CAG动物模型,以胃复春为对照组,观察加味七方胃痛颗粒对大鼠CAG相关指标的作用.结果 与模型组比较,加味七方胃痛颗粒高、中剂量组和胃复春组的胃黏膜萎缩程度、胃黏膜肠化生程度明显减轻(P＜0.01);加味七方胃痛颗粒高、中、低剂量组和胃复春组胃蛋白酶的含量、HSP70蛋白表达显著增加(P＜0.01);与胃复春组比较,加味七方胃痛颗粒高剂量组胃蛋白酶的含量、HSP70蛋白表达显著增加(P＜0.05).结论 加味七方胃痛颗粒防治CAG的作用机制可能是通过升高胃蛋白酶的含量及促进HSP70的表达,从而发挥对黏膜保护作用.
Objective It is to observe the correlation of pathological changes of chronic atrophic gastritis ( CAG) precan-cerous lesions with TCM syndrome type and transient receptor potential (TRPV1, TRPM8), and provide more objective basis of TCM syndrome differentiation for CAG .Methods317 patients with CAG diagnosed by endoscopy and CAG with atypical hy-perplasia or different levels intestinal metaplasia diagnosed by pathology were selected ;10 cases with asymptomatic superficial gastritis found by regular physical examination were selected as a control .The detection of TRPV1 receptors , TRPM8 expres-sion and the CAG syndrome types of TCM syndrome differentiation were done , and the correlation of pathological changes of CAG with TCM syndrome type and the correlation of TRPV 1, TRPM8 expression were analyzed ,Results①The TCM syndrome type of CAG precancerous lesions were accorded to the sort of spleen deficiency and Qi stagnation >Spleen stomach damp heat >weakness of spleen and stomach >Liver stomach disharmony >Stomach yin deficiency >stomach collaterals stasis resistance .②There were significant difference in the expression of TRPV 1 and TRPM8 between the six TCM syndrome types . The syndrome types were sorted to Spleen stomach damp heat >Stomach yin deficiency >Liver stomach disharmony >stom-ach collaterals stasis resistance >spleen deficiency and Qi stagnation >weakness of spleen and stomach for TRPV 1 expres-sion and sorted to weakness of spleen and stomach >spleen deficiency and Qi stagnation >stomach collaterals stasis resist-ance >Liver stomach disharmony >Stomach yin deficiency >Spleen stomach damp heat for TRPM 8 expression .TRPV1 was expressed obviously in Spleen stomach damp heat type at 415 bp, TRPM8was expressed obviously in weakness of spleen and stomach type at387 bp.stomach collaterals stasis resistance type was similar the expression of superficial gastritis gastric mu -cosa.③There was significant difference in the same syndrome among different
Mahony, M. J.; Wyatt, J I; Littlewood, J M
Campylobacter pylori colonisation of the stomach is strongly associated with type B non-autoimmune gastritis in adults. In a retrospective study of 38 gastric biopsy specimens taken during upper gastrointestinal endoscopy in children attending this hospital we found C pylori in nine (24%). Ten biopsy specimens showed histological evidence of gastritis and C pylori was found in eight.
This paper reports on the CT scans of patients with Helicobacter pylori (formerly Campylobacter pylori) infection and histologic gastritis reviewed to determine if the inflammatory changes can mimic the CT appearance of gastric neoplasm. Records were obtained of 288 consecutive cases of biopsy-confirmed. Helicobacter pylori gastritis, spanning a 21-month period from July 1988 to March 1990. Abdominal CT scans had been performed in 70 of these cases and were retrospectively reviewed. RESULTS: Seven of the 70 cases of confirmed Helicobacter pylori gastritis were suggestive of malignancy on CT
Tae Young Oh; Chang Yell Shin; Yong Sung Sohn; Dong Hwan Kim; Byoung Ok Ahn; Eun Bang Lee; Cho Hyun Park
AIM: To investigate the therapeutic effects of DA-9601 on sodium taurocholate (TCA)-induced chronic reflux gastritis in SD rats.METHODS: In this study, we have investigated the therapeutic effects of DA-9601 on chronic erosive and atrophic gastritis induced by 6 mo of TCA administration (5 mmol/L in drinking water) in SD rats. RESULTS: Four weeks of DA-9601 administration (0.065%, 0.216% in rat chow), following the withdrawal of TCA treatment, resulted in a significant decrease in total length of erosions in rats in a dose-dependent manner. Furthermore, the indicators of atrophic gastritis, such as reduced mucosal thickness and reduction in the number of parietal cells, were improved by the administration of DA-9601 in a dose-related manner. DA-9601 also attenuated inflammatory cell infiltration and the proliferation of collagenous fiber in the gastric mucosa. The improvement in the reduction of the gastric mucus was observed in the rats receiving a high dose of DA-9601 (0.216%). The therapeutic effect of DA-9601 on experimental chronic erosive gastritis was superior to that of rebamipide (1.08% in rat chow). Biochemical analyses showed increased mucosal prostaglandin E2 and reduced glutathione levels by DA-9601 treatment. CONCLUSION: We suggest that DA-9601 is apromising agent for the treatment of chronic erosive and atrophic gastritis with an etiological factor of bile reflux. Increasedmucosal prostaglandin E2 and reduced glutathione by DA-9601 treatment may be therapeutic mechanisms for chronic erosive and atrophic gastritis.
Pascotto, Ernesto; Capraro, Diego; Tomè, Paolo; Spanghero, Mauro
The aim of this paper was to determine the topographic distribution of gastritis lesions in pigs through an open source geographic information system (GIS) software analysis. The stomachs of 146 Italian heavy pigs were collected at slaughter and subjected to macroscopic pathological examination of the internal mucosa. A total of 623 lesions were either classified as hyperplastic or follicular (97%) with the remaining minority of lesions categorised as atrophic and simple. The hyperplastic gastritis lesions had an average surface of 77.8 cm2 and were mainly located in an oval shaped area of the fundus region of the stomach near the Curvatura ventriculi major. The follicular gastritis lesions had generally a smaller surface (40.3 cm2) and were concentrated in two distinct small areas of the pyloric region. The GIS analysis provided the opportunity to produce useful maps showing the distribution and characteristics of gastritis in pigs. PMID:27245806
Zaitoun, A M
AIMS--To determine the prevalence of Helicobacter pylori in five main nationality groups with gastric ulcer, duodenal ulcer, and non-ulcer dyspepsia; and to determine the histopathological types of gastritis and assess the graded variables of Helicobacter associated gastritis. METHODS--Gastric antral and corpus biopsy specimens from 437 patients were examined for the prevalence of H pylori, 337 of which were classified and graded histologically according to the Sydney system. RESULTS--The ove...
Winter, Susann; Rehm, Armin; Wichner, Katharina; Scheel, Tobias; Batra, Arvind; Siegmund, Britta; Berek, Claudia; Lipp, Martin; Höpken, Uta E.
Autoimmune gastritis is a common autoimmune disorder characterized by chronic inflammatory cell infiltrates, atrophy of the corpus and fundus, and the occurrence of autoantibodies to parietal cell antigen. In CCR7-deficient mice, autoimmune gastritis developed spontaneously and was accompanied by metaplasia of the gastric mucosa and by the formation of tertiary lymphoid organs at gastric mucosal sites. T cells of CCR7-deficient mice showed an activated phenotype in the gastric mucosa, mesente...
Stolte, Manfred; Meining, Alexander
In recent years, the importance of the histological diagnosis of gastritis on the basis of routinely obtained antral and corpus biopsies has increased enormously, which is owed not least of all to the discovery of Helicobacter pylori. The introduction of the Sydney system made it possible, for the first time, to grade histological parameters, identify topographical distribution and, finally, make a statement about the etiopathogenesis of the gastritis. Of pathogenetic importance is, in the fi...
Qvist, N; Rasmussen, L; Axelsson, C K
Twenty-five patients with dyspepsia were included. In 19 patients with a median age of 48 (range, 20-72) years endoscopy and histologic examination of biopsy specimens from the antrum and corpus of the stomach showed Helicobacter pylori-positive gastritis as the only pathologic finding. In six......-positive gastritis. Nine patients were reexamined after eradication of the H. pylori infection, and the motility pattern had changed to the characteristics found in normals. In conclusion, the patients with dyspepsia and gastritis showed a disturbed motility pattern. The disturbance was similar whether there was...... patients with a median age of 42 (range, 32-56) years H. pylori-negative gastritis was found. After an overnight fast the patients underwent an ambulatory duodenal motility study for 6-8 h. Twenty-five young healthy men served as the control group. In patients with H. pylori-positive gastritis the duration...
Objective: To determine the frequency of precancerous lesions in endoscopic gastric biopsies of patients with chronic gastritis. Study Design: A case series. Place and Duration of Study: Department of Histopathology, Liaquat National Hospital, Karachi, from July 2008 to January 2009. Methodology: Over 6 months, 375 endoscopic gastric biopsies of patients with age group of 15-65 years having endoscopic chronic gastritis were included. From final biopsy report, basic information like patient demographics and presence of precancerous lesions i.e. activity (chronic active gastritis), atrophy (atrophic gastritis), intestinal metaplasia and dysplasia were recorded on proforma. Results were described as proportions and frequency. Results: The frequency of precancerous lesions in endoscopic gastric biopsies of patients with chronic gastritis in Karachi was markedly high. Most common lesion was chronic active gastritis as depicted by activity (48.3%); dysplasia (1.3%) was the least common. Proportion of more aggressive precancerous lesions were markedly higher in older age group (> 40 years). Conclusion: The precancerous lesions are frequent in endoscopic gastric biopsies of patients with chronic gastritis. (author)
Wyatt, J I; Shallcross, T M; Crabtree, J E; Heatley, R V
AIMS: To determine the histopathological types of gastritis, presence of H pylori, and of peptic ulceration in patients aged 70 and over, compared with younger adults. METHODS: Gastric antral and corpus biopsy specimens from 112 elderly patients were classified and graded histologically according to the Sydney system. Details of recent antibiotic and non-steroidal anti-inflammatory drug use were recorded. Eighty four of the patients were positive for H pylori IgG antibodies and parietal cell ...
T Knight; Wyatt, J.; Wilson, A.; GREAVES, S.; Newell, D; Hengels, K.; Corlett, M.; Webb, P.; Forman, D; Elder, J
This study aimed to estimate the prevalence and type of chronic gastritis in an asymptomatic working population and to determine whether a combination of serum pepsinogen levels and Helicobacter pylori serology could be used to identify a subgroup with atrophic gastritis at elevated risk of gastric carcinoma. A 10% subsample of 544 male volunteer factory workers aged 18-63 years and participating in a larger study underwent endoscopy and biopsy. Of these men, 29 were seropositive for Helicoba...
Christian Kirsch; Ahmed Madisch; Petja Piehler; Ekkehard Bayerd(o)rffer; Manfred Stolte; Stephan Miehlke
AIM: To determine the long-term prevalence of Helicobacter pylori (H pylori) gastritis in patients after partial gastric resection due to peptic ulcer, and to compare the severity of H pylori-positive gastritis in the corpus mucosa between partial gastrectomy patients and matched controls.METHODS: Endoscopic biopsies were obtained from 57 patients after partial gastric resection for histological examination using hematoxylin/eosin and Warthin-Starry staining. Gastritis was graded according to the updated Sydney system. Severity of corpus gastritis was compared between H pylori-positive partial gastrectomy patients and H pylori-positive duodenal ulcer patients matched for age and gender.RESULTS: In partial gastrectomy patients, surgery was performed 20 years (median) prior to evaluation. In 25 patients (43.8%) H pylori was detected histologically in the gastric remnant. Gastric atrophy was more common in H pylori-positive compared to H pylori-negative partial gastrectomy patients (P＜0.05). The severity of corpus gastritis was significantly lower in H pylori-positive partial gastrectomy patients compared to duodenal ulcer patients (P＜0.01). There were no significant differences in the activity of gastritis, atrophy and intestinal metaplasia between the two groups.CONCLUSION: The long-term prevalence of H pylorigastritis in the gastric corpus of patients who underwent partial gastric resection due to peptic ulcer disease is comparable to the general population. The expression of H pylori gastritis in the gastric remnant does not resemble the gastric cancer phenotype.
Syphilitic involvement of the stomach often takes the appearance of neoplastic conditions. We describe the radiological findings of syphilitic gastritis. A 36 year old man was diagnosed with gastric cancer by upper GI and CT, but syphilitic gastritis was confirmed by endoscopy and upper GI series performed after penicillin therapy. We report a case of syphilitic gastritis presented as advanced stomach cancer by clinical, endoscopic and radiological study
Emphysematous gastritis is a rare entity of infectious gastritis caused by gas-forming organisms and only 32 cases have been reported. CT is helpful in the diagnosis particularly in mild cases that there is only a small amount of gas. Typical CT findings of emphysematous gastritis are gas bubbles within the irregular thickened gastric wall and dilated stomach filled with secretions, debris and a large amount of gas. We report a case that was diagnosed by CT and operation.
Abnormal gastric wall configurations in 27 cases of cause-unknown acute gastritis were studied roentgenographically with reference to their causative origins. Studies were made on roentgenograms (abnormal gastric wall configurations), endoscopic findings and extension of lesions of the subjected cases. Gastric contour showed 'staying', 'thumbprinting', 'undulate configuration' and 'squarish undulation', while 'chimney-like' finding suggestive of poor gastric wall stretch was observed in the whole antral region as well. The widened angulus ventriculi and expanded pyloric ring (insufficient constriction) were also seen. In some cases the lesion extended over to the duodenum and, as in the cases of acute gastritis, duodenal wall 'staying', 'thumbprinting' and varied duodenal wall undulation were seen in addition to edema and morphological changes of the Kerkring's folds. The lesions in the studied patients mostly extended from an epicenter of the antrum upward to the gastric corpus and downward near to Vater's papilla in the descending part of the duodenum. The affected regions were clearly distinguishable. It has been known that above-described roentgenographical findings in our studied patients were similar in part to those known in experimental studies carried out on animals with ischemic digestive tract. This strongly suggests that some of our patients had developed the disease due to ischemic causes. There were some discrepancies between roentgenographical (abnormal gastric wall configuration) and endoscopic findings in some studied patients. It has been our belief that abnormal gastric wall configuration reflects lesions in the inner part of the wall and, accordingly, roentgenographical examinations, as well as endoscopy, should be performed for the purpose of making correct diagnosis. It is also to be emphasized that angiography should be carried out on patients with relapsing acute gastritis without any specific cause. (author)
Full Text Available Aim. To assess the predictive value for chronic autoimmune gastritis (AIG of the combined assay of anti-parietal-cell antibodies (PCA, anti-intrinsic-factor antibodies (IFA, anti-Helicobacter pylori (Hp antibodies, and measurement of blood gastrin. Methods. We studied 181 consecutive patients with anemia, due to iron deficiency resistant to oral replacement therapy or to vitamin B12 deficiency. Results. 83 patients (45.8% tested positive for PCA and underwent gastroscopy with multiple gastric biopsies. On the basis of the histological diagnosis, PCA-positive patients were divided into 4 groups: (1 30 patients with chronic atrophic gastritis; they had high concentrations of PCA and gastrin and no detectable IFA; (2 14 subjects with metaplastic gastric atrophy; they had high PCA, IFA, and gastrin; (3 18 patients with nonspecific lymphocytic inflammation with increased PCA, normal gastrin levels, and absence of IFA; (4 21 patients with multifocal atrophic gastritis with “borderline” PCA, normal gastrin, absence of IFA and presence of anti-Hp in 100% of the cases. Conclusions. The assay of four serological markers proved particularly effective in the diagnostic classification of gastritis and highly correlated with the histological profile. As such, this laboratory diagnostic profile may be considered an authentic “serological biopsy.”
Joo, Mee; Kwak, Ji Eun; Chang, Sun Hee; Kim, Hanseong; Chi, Je G.; Kim, Kyung-Ah; Yang, Jeon Ho; Lee, June Sung; Moon, Young-Soo; Kim, Kyoung-Mee
The aims of this study were to evaluate the clinicopathologic features of Helicobacter heilmannii-associated gastritis and to compare H. heilmannii-associated gastritis with H. pylori-associated gastritis. We reviewed 5,985 consecutive gastric biopsy specimens. All cases of chronic gastritis with Helicobacter infection were evaluated with the Updated Sydney System, and the grades of all gastritis variables were compared between H. heilmannii-associated gastritis and H. pylori-associated gastr...
Chuan Zhang; Nobutaka Yamada; Yun-Lin Wu; Min Wen; Takeshi Matsuhisa; Norio Matsukura
AIM: To evaluate the histological features of gastric mucosa, including Helicobacter pylori infection in patients with early gastric cancer and endoscopically found superficial gastritis, gastric erosion, erosive gastritis,gastric ulcer.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of all the patients.Giemsa staining, improved toluidine-blue staining, and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylin-eosin staining was used for the histological diagnosis of gastric mucosa inflammation, gastric glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: The overall prevalence of H pylori infection in superficial gastritis was 28.7%, in erosive gastritis 57.7%,in gastric erosion 63.3%, in gastric ulcer 80.8%, in early gastric cancer 52.4%. There was significant difference (P＜0.05), except for the difference between early gastric cancer and erosive gastritis. H pylori infection rate in antrum, corpus, angulus of patients with superficial gastritis was 25.9%, 26.2%, 25.2%, respectively; in patients with erosive gastritis 46.9%, 53.5%, 49.0%,respectively; in patients with gastric erosion 52.4%, 61.5%,52.4%, respectively; in patients with gastric ulcer 52.4%,61.5%, 52.4%, respectively; in patients with early gastric cancer 35.0%, 50.7%, 34.6%, respectively. No significant difference was found among the different site biopsies in superficial gastritis, but in the other diseases the detected rates were higher in corpus biopsy (P＜0.05). The grades of mononuclear cell infiltration and polymorphonuclear cell infiltration, in early gastric cancer patients, were significantly higher than that in superficial gastritis patients, lower than that in gastric erosion and gastric ulcer patients (P＜0.01);however, there was no significant difference compared with erosive gastritis. The grades
Gozali, Maya Valeska; ZHOU, BINGRONG
Atrophic scarring is often an unfortunate and permanent complication of acne vulgaris. It has high prevalence, significant impact on quality of life, and therapeutic challenge for dermatologists. The treatment of atrophic acne scars varies depending on the types of acne scars and the limitations of the treatment modalities in their ability to improve scars. Therefore, many options are available for the treatment of acne scarring, including chemical peeling, dermabrasion, laser treatment, punc...
Halme, L; Kärkkäinen, P; Rautelin, H; Kosunen, T. U.; Sipponen, P.
The frequency of gastric Crohn's disease has been considered low. This study was undertaken to determine the prevalence of chronic gastritis and Helicobacter pylori infection in patients with Crohn's disease. Oesophagogastroduodenoscopy was performed on 62 consecutive patients suffering from ileocolonic Crohn's disease. Biopsy specimens from the antrum and corpus were processed for both histological and bacteriological examinations. H pylori antibodies of IgG and IgA classes were measured in ...
Jakubíček Miloš; Rychlý Pavel; Kilgarriff Adam
In this paper we describe an implementation of corpus virtualization within the Manatee corpus management system. Under corpus virtualization we understand logical manipulation with corpora or their parts grouping them into new (virtual) corpora. We discuss the motivation for such a setup in detail and show space and time efficiency of this approach evaluated on a 11 billion word corpus of Spanish.
XML Old Persian corpus. The corpus is based on publicly available data on the Web. Those data can be traced back to the grammar of Old Persian by Kent (1950). The corpus contains those data and is arranged in a way suitable for corpus searches.
Švagelj, Dražen; Terzić, Velimir; Dovhanj, Jasna; Švagelj, Marija; Cvrković, Mirta; Švagelj, Ivan
Human gastric diseases have shown significant changes in the activity and expression of superoxide dismutase (SOD) isoforms. The aim of this study was to detect Mn-SOD activity and expression in the tissue of gastric mucosa, primarily in chronic gastritis (immunohistochemical Helicobacter pylori-negative gastritis, without other pathohistological changes) and to evaluate their possible connection with pathohistological diagnosis. We examined 51 consecutive outpatients undergoing endoscopy for upper gastrointestinal symptoms. Patients were classified based on their histopathological examinations and divided into three groups: 51 patients (archive samples between 2004-2009) with chronic immunohistochemical Helicobacter pylori-negative gastritis (mononuclear cells infiltration were graded as absent, moderate, severe) divided into three groups. Severity of gastritis was graded according to the updated Sydney system. Gastric tissue samples were used to determine the expression of Mn-SOD with anti-Mn-SOD Ab immunohistochemically. The Mn-SOD expression was more frequently present in specimens with severe and moderate inflammation of gastric mucosa than in those with normal mucosa. In patients with normal histological finding, positive immunoreactivity of Mn-SOD was not found. Our results determine the changes in Mn-SOD expression occurring in the normal gastric mucosa that had undergone changes in the intensity of chronic inflammatory infiltrates in the lamina propria. PMID:26765960
Massimo; Montalto; Antonella; Gallo; Gianluca; Ianiro; Luca; Santoro; Ferruccio; D; Onofrio; Riccardo; Ricci; Giovanni; Cammarota; Marcello; Covino; Monica; Vastola; Antonio; Gasbarrini; Giovanni; Gasbarrini
AIM:To evaluate fecal calprotectin concentrations(FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.METHODS:FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers.Histological grading of gastritis was performed according to the updated Sydney gastritis classification.Patients were subdivided into 2 groups according to the presence/absence of an active gastritis.Patients with chronic active gastritis were di...
ZHAO Yi; YU Yue-juan; XIAO Yuan-chun
@@ ZHAO Guo-cen, a senior doctor born in 1937, is a member of China Association of Traditional Chinese Medicine and one of the 500 well-known supervisors qualified to instruct disciples. He was born into a Chinese medicine family and has been engaging himself in the treatment of digestive disorders. He is an expert at internal medicine and acupuncture. His main clinical experience is summarized as "Nourishing spleen and stomach to treat digestive disorders, nourishing spleen and kidneys to treat diabetes mellitus, supplementing heart-qi and activating stagnated blood to treat chest distress, and restoring kidney-qi and balancing yin and yang to treat infertility."
Kawther El-Shafie; Nafisa Samir; Ritu Lakhtakia; Robin Davidson; Ahmed Al-Waili; Muna Al-Mamary; Mohammed Al-Shafee
Vitamin B12 deficiency is common in developing countries and should be suspected in patients with unexplained anaemia or neurological symptoms. Dermatological manifestations associated with this deficiency include skin hyper- or hypopigmentation, angular stomatitis and hair changes. We report a case of a 28-year-old man who presented to the Sultan Qaboos University Hospital in Muscat, Oman, in November 2013 with localised hyperpigmentation of the palmar and dorsal aspects of both hands of two...
Aditi, Anupam; Graham, David Y
The discovery of Helicobacter pylori as the cause of gastritis and peptic ulcers ushered in the modern era of research into gastritis and into acid-peptic diseases and rekindled interest in the role of ascorbic acid in the pathophysiology and treatment of gastritis and peptic ulcer disease. Here, we review historic and modern studies on ascorbic acid and gastric diseases with an emphasis on H. pylori gastritis and its sequelae. The relationship of ascorbic acid and gastritis and peptic ulcer and its complications was extensively studied during the 1930s through the 1950s. Much of this extensive literature has been effectively "lost." Ascorbic acid deficiency was associated with all forms of gastritis (e.g., autoimmune, chemical, and infectious) due in varying degrees to insufficient intake, increased metabolic requirements, and destruction within the GI tract. Importantly, gastritis-associated abnormalities in gastric ascorbic acid metabolism are reversed by H. pylori-eradication and potentially worsened by proton pump inhibitor therapy. Diets rich in naturally occurring ascorbic acid are associated with protection of the gastric corpus from atrophy and a reduction in the incidence of gastric cancer possibly through the ability of ascorbic acid to reduce oxidative damage to the gastric mucosa by scavenging carcinogenic N-nitroso compounds and free radicals and attenuating the H. pylori-induced inflammatory cascade. Ascorbic acid supplementation was possibly associated with a decreased incidence of bleeding from peptic ulcer disease. Pharmacologic doses of ascorbic acid also may improve the effectiveness of H. pylori-eradication therapy. Occasionally, looking back can help plot the way forward. PMID:22543844
Corpus linguistics has been widely applied in English teaching. Corpus linguistics has changed the way to teach English. The essay discusses two approaches in English teaching based on corpus, corpus-driven approach and corpus-based approach. It finds out that both corpus-driven approach and corpus-based approach facilitate English teaching in their own ways.
Haot, J; Jouret, A.; Willette, M; Gossuin, A; Mainguet, Paul
Lymphocytic gastritis is a new histopathological entity characterised by a dense lymphocytic infiltration of surface and pit gastric epithelium. Previous retrospective work has suggested that lymphocytic gastritis is related to an endoscopic form of gastropathy comprising enlarged folds, nodules and erosions, commonly denoted as varioliform gastritis. In the present prospective study, the relationship is clearly shown; nearly 82% (54/66) of the varioliform gastritis observed in four different...
Villablanca, Pedro A.; Sukhal, Shashvat; Ansari, Asimul; Mohammed, Dergham
Key Clinical Message A 50-year-old lady presented with epigastralgia, electrocardiogram (ECG) showed T-wave inversions and the echocardiogram low ejection fraction (EF) with apical ballooning. An esophagogastroduodenoscopy (EGD) revealed gastritis. She recovered with proton pump inhibitors treatment. This is the first case that describes gastritis-induced stress cardiomyopathy. Clinicians should be aware of Takotsubo's cardiomyopathy (TCM) as a possible complication of gastritis.
Massimo Montalto, Antonella Gallo, Gianluca Ianiro, Luca Santoro, Ferruccio D’Onofrio, Riccardo Ricci, Giovanni Cammarota, Marcello Covino, Monica Vastola, Antonio Gasbarrini, Giovanni Gasbarrini
AIM: To evaluate fecal calprotectin concentrations (FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score.METHODS: FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers. Histological grading of gastritis was performed according to the updated Sydney gastritis classification. Patients were subdivided into 2 groups according to the presence/absence of an active gastritis. Patients with chronic act...
Barakat, Manal; Awad, Sherif; Medhat, Walid; El-Fakahany, Hasan; Farag, Hanna
Objective: Treatment of acne scarring is always a challenge. Microneedling therapy or percutaneous collagen induction is a new addition to the treatment modalities for such scars and has been reported to be simple and effective in atrophic acne scar treatment. The aim of this study is to evaluate the clinical effect and objectively quantify the histological changes of acne scarring in response to skin microneedling. Design: A prospective clinical study. Participants: Ten patients with different types of atrophic acne scars were subjected to three months of skin microneedling treatment (six sessions at two-week intervals). Measurements: Patients were photographed, and skin biopsies were obtained at baseline as well as one and three months from the start of treatment. Histometry for epidermal thickness and quantitative evaluation of total elastin; newly synthesized tropoelastin; collagen types I, III, and VII; and newly synthesized collagen were performed for all biopsies. Results: Compared to the baseline, patients’ evaluations revealed noticeable clinical improvement in atrophic post-acne scars in response to skin microneedling. There was a statistically significant increase (pmicroneedling are an effective treatment for post-acne atrophic scars as it stimulates the repair processes with the advantage of being a relatively risk-free, in-office procedure with minimal patient recovery time. PMID:26203319
Une question lancée comme un défi a sous-tendu ce numéro de Corpus. Parallèlement aux linguistiques de corpus qui commencent à être clairement établies, serait-il envisageable de définir une stylistique de corpus ? Ou bien formulé autrement, que peut être un corpus pertinent en stylistique ? Quelles sont ses spécificités, si elles existent ? Articulant la problématique du corpus et l’analyse stylistique, les contributeurs explorent ce faisant des enjeux épistémologiques qui font envisager un ...
Radhi, J; Kamouna, M; Nyssen, J.
Phlegmonous gastritis is a rare, rapidly progressive and potentially fatal gastric bacterial infection. A case of phlegmonous gastritis following a coronary bypass surgery is described. This condition was not diagnosed premortem due to the nonspecific nature of the gastrointestinal symptoms. Upper gastrointestinal endoscopy may be of value in establishing the diagnosis in emergencies with culture of gastric aspirate and biopsy.
Siregar, Gontar Alamsyah; Sitepu, Ricky Rivalino; Halim, Sahat
Gastritis ialah proses peradangan pada lapisan mukosa dan submukosa lambung sebagai respon terhadap jejas (injury). Gastritis berbeda dengan dispepsia, yang merupakan suatu sindroma klinis. Sementara gastritis merupakan diagnosis yang bisa ditegakkan secara histologis, bukan secara klinis. Pada gastritis terjadi respons inflamasi baik akut maupun kronik dimana faktor-faktor proinflamasi, atau disebut dengan sitokin, teraktivasi dan menyebabkan terjadinya inflamasi mukosa. Infeksi dengan k...
... hands with soap and water after using the bathroom and before eating eat food that has been ... La Información de la Salud en Español Health Statistics Healthy Moments Radio Broadcast Clinical Trials For Health ...
... with a bacteria called Helicobacter pylori Less common causes are: Autoimmune disorders (such as pernicious anemia) Backflow of bile into the stomach (bile reflux) Cocaine abuse Eating or drinking caustic or corrosive substances (such as ...
Emphysematous gastritis is a rare form of gastritis that results from infection of the stomach wall by gas-forming organisms. Diagnosis of this commonly fatal condition rests on radiological demonstration of gas within the stomach wall. This can be observed on plain radiographs or CT scans of the abdomen. Only by prompt diagnosis and treatment can mortality be avoided. A new case of empysematous gastritis, diagnosed on CT scan by the demonstration of both intramural and portal venous gas, is presented and the literature is reviewed. Copyright (2001) Blackwell Science Pty Ltd
Mosnier, J F; Flejou, J F; Amouyal, G; Gayet, B; Molas, G.; Henin, D; Potet, F
Lymphocytic gastritis is a form of gastric inflammation characterised by a pronounced increase in lymphocytes in gastric surface and foveolar epithelium. Lymphocytic gastritis is often associated with endoscopic evidence of 'varioliform gastritis'. Lymphocytic gastritis has recently been reported to be associated with other forms of hypertrophic gastropathies. We present a case of hypertrophic gastropathy with gastric adenocarcinoma, with both Menetrier's disease and lymphocyte gastritis. Imm...
Makki, Ahmed Mohammad; Aldaqal, Saleh Mohammad; Alorabi, Shahad Hamadan; Nemri, Ismail Ahmed; Alajami, Maha Mohammad
Introduction Obesity is a condition that has significant impact on public health. Recent exciting studies have linked chronic gastritis and H. pylori infection to obesity. Chronic gastritis has shown increased prevalence in obesity, more particularly H. pylori-related gastritis. This study aimed to determine the prevalence of chronic gastritis in morbidly obese patients who were subjected to sleeve gastrectomy, with focus on H. pylori-related gastritis. The aim was to demonstrate any influenc...
Shilpa Garg; Sukriti Baveja
Background: Atrophic acne scars are difficult to treat. The demand for less invasive but highly effective treatment for scars is growing. Objective: To assess the efficacy of combination therapy using subcision, microneedling and 15% trichloroacetic acid (TCA) peel in the management of atrophic scars. Materials and Methods: Fifty patients with atrophic acne scars were graded using Goodman and Baron Qualitative grading. After subcision, dermaroller and 15% TCA peel were performed alternatively...
To assess the sensitivity of radiology in diagnosis of gastritis within 2 hours endoscopy and biopsy of the stomach and double contrast barium meal were performed. The diagnosis was established of the morphologic picture of the areae gastricae, which were sufficient visible in 33 out of 50 cases (66%). In 7 patients radiologic findings were normal, 13 patients showed superficial gastritis, 10 patients had superficial gastritis with signs of atrophy and in 3 patients there was an erosive gastritis. In all 33 patients (100%) there was a complete correlation of radiologic and endoscopic findings, in 24 out of 33 cases (73%) even correlation between radiologic and histologic classification. These results are discussed and confrontated with literatures. (orig.)
Shim, Joo Eun; Kim, Ho Chul; Bae, Sang Hoon; Cho, So Yeon [Hallym Univ. College of Medicine, Chunchon (Korea, Republic of)
Gastritis cystica profunda is an uncommon benign mass that usually occurs on the gastric side of the site of a gastroenterostomy, but has also been known to develop in which has not been operated on. We report the case of stomach a 51-years-old man with pathologically proven gastritis cystica profunda. This patient had not undergone gastric surgery CT showed a well-defined, 3cm sized, cystic mass at the gastric antrum.
Gastritis cystica profunda is an uncommon benign mass that usually occurs on the gastric side of the site of a gastroenterostomy, but has also been known to develop in which has not been operated on. We report the case of stomach a 51-years-old man with pathologically proven gastritis cystica profunda. This patient had not undergone gastric surgery CT showed a well-defined, 3cm sized, cystic mass at the gastric antrum
Cecilia Rodríguez, Marta Medici, Fernanda Mozzi, Graciela Font de Valdez
Full Text Available AIM: To investigate the potential therapeutic effect of exopolysaccharide (EPS-producing Streptococcus thermophilus (S. thermophilus CRL 1190 fermented milk on chronic gastritis in Balb/c mice.METHODS: Balb/c mice were fed with the fermented milk for 7 d after inducing gastritis with acetyl-salicylic acid (ASA, 400 mg/kg body weight per day for 10 d. Omeprazole was included in this study as a positive therapeutic control. The gastric inflammatory activity was evaluated from gastric histology and inflammation score, number of interleukin-10 (IL-10, interferon-γ (INFγ and tumor necrosis factor-α (TNF-α cytokine-producing cells in the gastric mucosa, and thickness of the mucus layer.RESULTS: Animals receiving treatment with the EPS-producing S. thermophilus CRL 1190 fermented milk showed a conserved gastric mucosa structure similar to that of healthy animals. Inflammation scores of the fermented milk-treated mice were lower than those of mice in the gastritis group (0.2 ± 0.03 vs 2.0 ± 0.6, P < 0.05. A marked decrease in INFγ+ (15 ± 1.0 vs 28 ± 1.2, P < 0.05 and TNF-α+ (16 ± 3.0 vs 33 ± 3.0, P < 0.05 cells and an increase in IL-10+ (28 ± 1.5 vs 14 ± 1.3, P < 0.05 cells compared to the gastritis group, was observed. Also, an increase in the thickness of the mucus gel layer (2.2 ± 0.6 vs 1.0 ± 0.3; 5.1 ± 0.8 vs 1.5 ± 0.4 in the corpus and antrum mucosa, respectively, P < 0.05 compared with the gastritis group was noted. A milk suspension of the purified EPS from S. thermophilus CRL1190 was also effective as therapy for gastritis.CONCLUSION: This study suggests that fermented milk with S. thermophilus CRL 1190 and/or its EPS could be used in novel functional foods as an alternative natural therapy for chronic gastritis induced by ASA.
Full Text Available Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL in gastric juice in healthy adolescents and in patients with gastritis. The adolescents were allocated to three groups: the first including patients with Helicobacter pylori gastritis (HPG; n = 10, the second including patients with superficial gastritis caused by pathogens other than H. pylori (non-HPG; n = 14 and the control group including healthy adolescents (n = 14. Activity of HGL was measured in gastric juice collected during endoscopy. Plasma concentrations of cholecystokinin (CCK, glucagon-like peptide-1 (GLP-1 and glucose-dependent insulinotropic peptide (GIP were measured in all adolescents. Activity of HGL in the non-HPG group was significantly lower than in the HPG group (p < 0.005 and the control group (p < 0.005. Mean plasma GIP levels in the control group were lower than in the non-HPG group (p < 0.003 and the HPG group (p < 0.01. We conclude that the regulation of HGL secretion by GLP-1 and CCK is altered in patients with gastritis. Moreover, GIP is a potent controller of HGL activity, both in healthy subjects and in patients with gastritis.
Ning, Jian-Wen; Lin, Guan-Bin; Ji, Feng; Xu, Jia; Sharify, Najeeb
AIM: To establish a rat ethanol gastritis model, we evaluated the effects of ethanol on gastric mucosa and studied the preventive effects of geranylgeranylacetone on ethanol-induced chronic gastritis.
Epithelial cell proliferation in the fundic and antral mucosae was studied in 19 duodenal ulcer patients, 11 patients having undergone fundic superselective vagotomy for duodenal ulcer, and 10 controls. This was achieved through in vitro incorporation of tritiated thymidine in mucosal biopsies and radioautography. Except for increased fundic mucosal height, duodenal ulcer patients did not differ from controls for all parameters studied. In vagotomized patients, as compared to the other two groups, the labeling index was significantly enhanced in the innervated antral mucosa where atrophic gastritis developed, but there was no change in the labeling index and no worsening of mucosal inflammation in the denervated fundic mucosa. The only abnormality in the latter was a striking expansion, towards the surface, of the proliferative area within the fundic pit. The labeling indices and the degree of gastritis in gastric mucosae are significantly correlated in control and duodenal ulcer patients. If findings in antral mucosa, after superselective vagotomy, seemed related to gastritis lesions, those in fundic mucosa were not and may indicate an alteration due to the vagotomy per se
Andreas Leodolter; Matthias P Ebert; Ulrich Peitz; Kathlen Wolle; Stefan Kahl; Michael Vieth; Peter Malfertheiner
AIM: To investigate the prevalence of H pylori associated corpus-predominant gastritis (CPG) or pangastritis, severe atrophy, and intestinal metaplasia (IM) in patients without any significant abnormal findings during upper GI endoscopy.METHODS: Gastric biopsies from 3548 patients were obtained during upper GI-endoscopy in a 4-year period. Two biopsies from antrum and corpus were histologically assessed according to the updated Sydney-System.Eight hundred and forty-five patients (mean age 54.8 ±2.8 years) with H pylori infection and no peptic ulcer or abnormal gross findings in the stomach were identified and analyzed according to gastritis phenotypes using different scoring systems.RESULTS: The prevalence of severe H pylori associated changes like pangastritis, CPG, IM, and severe atrophy increased with age, reaching a level of 20% in patients of the age group over 45 years. No differences in frequencies between genders were observed. The prevalence of IM had the highest increase, being 4-fold higher at the age of 65 years versus in individuals less than 45 years.CONCLUSION: The prevalence of gastritis featuring at risk for cancer development increases with age. These findings reinforce the necessity for the histological assessment, even in subjects with normal endoscopic appearance. The age-dependent increase in prevalence of severe histopathological changes in gastric mucosa, however, does not allow estimating the individual risk for gastric cancer development-only a proper follow-up can provide this information.
Full Text Available Problem statement: Speech corpus is one of the major components in corpus-based synthesis. The quality and coverage in speech corpus will affect the quality of synthesis speech sound. Approach: This study proposes a corpus design for Malay corpus-based speech synthesis system. This includes the study of design criteria in corpus-based speech synthesis, Malay corpus based database design and the concatenation engine in Malay corpus-based synthesis system. A set of 10 millions digital text corpuses for Malay language has been collected from Malay internet news. This text corpus had been analyzed using word frequency count to find out all high frequency words to be used for designing the sentences for speech corpus. Results: Altogether 381 sentences for speech corpus had been designed using 70% of high frequency words from 10 million text corpus. It consists of 16826 phoneme units and the total storage size is 37.6Mb. All the phone units are phonetically transcribed to preserve the phonetic context of its origin that will be used for phonetic context unit. This speech corpus had been labeled at phoneme level and used for variable length continuous phoneme based concatenation. Speech corpus is one of the major components in corpus-based synthesis. The quality and coverage in speech corpus will affect the quality of synthesized speech sound. Conclusion/Recommendation: This study has proposed a platform for designing speech corpus especially for Malay Text to Speech which can be further enhanced to support more coverage and higher naturalness of synthetic speech.
Hicham El Bouhaddouti; Tarik Souiki; Khalid Mazine; Abdelmalek Ousadden; Khalid Mazaz; Khalid Ait Taleb
Necrosis of the stomach is rare. It occurs when there is vascular anomalies, gastric volvulus or her-niation and in infectious gastritis. We report a case in which infectious gastritis leads to a necrotiz-ing gastritis that is treated with urgent gastrectomy.
Ozawa, Toshifumi; Wachi, Eiko; Saitoh, Yasutoshi
A 59-year-old man who had ulcerative proctitis for 18 years visited our hospital because of stomach pain. Proctitis had been in remission stage for five recent years by the mesalazine administration. Esophagogastroduodenoscopy (EGD) showed scattered patchy erosions at the corpus of the stomach. Anti-acid secretory agents was administrated, however, erosive change worsened in multiplicity and in area. Biopsied specimen of gastric mucosa showed specific findings resembling to cryptitis, crypt abcess and focally enhanced gastritis. H. pylori infection was negative by some examinations. Our patient had no history of taking non steroidal anti-inflammatory drugs (NSAIDs) so far. From the findings above, it was considered that gastric lesion was strongly related to the ulcerative proctitis. 5-aminosalicylic acid (750 mg, three times daily) ground to powder was administered with predonisolon (20 mg, once daily). Five month later, all the erosions disappeared completely on EGD and biopsied specimen revealed a reduction of inflammatory cells. The present case has a rare gastric lesion with patchy pattern (not diffuse pattern) which is strongly associated with ulcerative proctitis. PMID:19122423
Sheng-Liang Chen; Jian-Zhong Mo; Zhi-Jun Cao; Xiao-Yu Chen; Shu-Dong Xiao
AIM: To investigate the influences of bile reflux on profiles of gastric mucosal lesions in patients with dyspepsia or chronic gastritis.METHODS: A total of 49 patients diagnosed with dyspepsia and chronic gastritis underwent 24-h ambulatory andsimultaneous monitoring of intragastric bilirubin absorbance and pH values, and then they were divided into bile refluxpositive group and bile reflux negative group. Severity of pathological changes in gastric mucosa including activeinflammation, chronic inflammation, intestinal metaplasia, atrophy and dysplasia as well as Helicobacter pylori (H pylori) infection at the corpus, incisura and antrum were determined respectively according to update Sydney system criteria. The profiles of gastric mucosal lesions in the two groups were compared, and correlations between time-percentage of gastric bilirubin absorbance ＞0.14 and severity of gastric mucosal lesions as well as time-percentage of gastric pH ＞4 were analyzed respectively. RESULTS: Thirty-eight patients (21 men and 17 women, mean age 44.2 years, range 25-61 years) were found existing with bile reflux (gastric bilirubin absorbance ＞0.14) and 11 patients (7 men and 4 women, mean age 46.2 years,range 29-54 years) were bile reflux negative. In dyspepsia patients with bile reflux, the mucosal lesions such as active inflammation, chronic inflammation, intestinal metaplasia, atrophy or H pylori infection in the whole stomach, especially in the corpus and incisura, were significantly more severe than those in dyspepsia patients without bile reflux. Moreover, the bile reflux time was well correlated with the severity of pathological changes of gastric mucosa as well as H pylori colonization in the near-end stomach, especially in the corpus region. No relevance was found between the time of bile reflux and pH ＞4 in gastric cavity. CONCLUSION: Bile reflux contributes a lot to mucosal lesions in the whole stomach, may facilitate H pylori colonization in the corpus region
Montalto, Massimo; Gallo, Antonella; Ianiro, Gianluca; Santoro, Luca; D’Onofrio, Ferruccio; Ricci, Riccardo; Cammarota, Giovanni; Covino, Marcello; Vastola, Monica; Gasbarrini, Antonio; Gasbarrini, Giovanni
AIM: To evaluate fecal calprotectin concentrations (FCCs) in subjects with chronic gastritis and the correlation between FCCs and gastritis activity score. METHODS: FCCs were measured in 61 patients with histological diagnosis of gastritis and in 74 healthy volunteers. Histological grading of gastritis was performed according to the updated Sydney gastritis classification. Patients were subdivided into 2 groups according to the presence/absence of an active gastritis. Patients with chronic active gastritis were divided into 3 subgroups on the basis of the activity score (mild, moderate, marked). FFCs in relation to Helicobacter pylori (H. pylori) infection and proton pump inhibitor (PPI) use were also evaluated. RESULTS: FCCs in patients with chronic active gastritis were not significantly different to FCCs either in subjects with non active gastritis or in healthy controls. Among patients with chronic active gastritis (even marked), FCCs did not significantly differ according to activity score. No significant differences in FCCs were found when considering H. pylori, as well as when considering PPI chronic use. CONCLUSION: FCCs were not significantly increased in subjects with chronic gastritis, even in those patients with a marked neutrophil infiltration. PMID:20632443
Lee, Sang Hwan; Park, Jong Min; Han, Young Min; Ko, Weon Jin; Hahm, Ki Baik
As a commensal or a pathogen, Helicobacter pylori can change the balance of a complex interaction that exists among gastric epithelial cells, microbes, and their environment. Therefore, unraveling this complex relationship of these mixtures can be expected to help prevent cancer as well as troublesome unmet medical needs of H. pylori infection. Though gastric carcinogenesis is a multi-step process, precancerous lesion can be reversible in the early phase of mucosal damage before reaching the stage of no return. However, biomarkers to predict rejuvenation of precancerous atrophic gastritis have not been identified yet and gastric cancer prevention is still regarded as an impregnable fortress. However, when we take the journey from H. pylori-associated gastritis to gastric cancer, it provides us with the clue for prevention since there are two main preventive strategies: eradication and anti-inflammation. The evidence supporting the former strategy is now ongoing in Japan through a nation-wide effort to eradicate H. pylori in patients with chronic gastritis, but suboptimal apprehension to increasing H. pylori resistance to antibiotics and patient non-compliance still exists. The latter strategy has been continued in the author'sresearch center under siTRP (short-term intervention to revert premalignant lesion) strategy. By focusing on the role of inflammation in the development of H. pylori-associated gastric carcinogenesis, this review is intended to explain the connection between inflammation and gastric cancer. Strategies on H. pylori eradication, removal of inflammation, and reverting preneoplastic lesion will also be introduced. In the end, we expect to be able to prevent gastric cancer by take a detour from the unpleasant journey, i.e. from H. pylori-associated gastritis to gastric cancer. PMID:26691187
Ahmed Kalebi; Farzana Rana; Walter Mwanda; Geoffrey Lule; Martin Hale
AIM: To conduct a detailed histological study of gastritis in adult patients attending an endoscopy clinic at a Kenyan teaching and referral hospital.METHODS: Biopsy specimens from consecutive patients were examined and graded according to the Updated Sydney System for H pylori infection, chronic inflammation, neutrophil activity, glandular atrophy and intestinal metaplasia. Also documented were gastric tissue eosinophil counts and presence of lymphoid follicles.RESULTS: The rate of the graded variables, in the antrum and corpus respectively, were as follows:H pylori infection (91%, 86%), chronic inflammation (98%, 93%),neutrophil activity (91%, 86%), glandular atrophy (57%,15%) and intestinal metaplasia (11%, 2%). Lymphoid follicles were noted in 11% of cases. Duodenal and gastric ulcers were documented in 32% and 2% respectively.The mean eosinophil count was 5.9 ± 0.74 eosinophils/HPF and 9.58 ± 0.93 eosinophils/HPF in the corpus and antrum respectively. Significant association was found between the degree of H pylori colonisation with chronic inflammation, neutrophil activity and antral glandular atrophy. Biopsies from the antrum and corpus showed significant histopathological discordance for all the graded variables.H pylori negative cases were associated with recent antibiotic use.CONCLUSION: The study reaffirms that H pylori is the chief cause of gastritis in this environment. The majority of patients show a moderate to high degree of inflammation but a low degree of glandular atrophy and intestinal metaplasia. The study shows that interrelationships between the histological variables in this African population are similar to those found in other populations worldwide including non-African populations.
Background: Atrophic facial scars are always a challenge to treat, especially the ones that are deep-seated and/or involve much of the face. Microneedling or dermaroller therapy is a new addition to the treatment armamentarium for such scars that offers a simple and reportedly effective management of these scars. Aims: The aim of the present study was to perform an objective evaluation of the efficacy of dermaroller treatment in atrophic facial scars of varying etiology. Materials and Met...
Quiding-Järbrink, Marianne; Raghavan, Sukanya; Sundquist, Malin
Background Infection with Helicobacter pylori triggers a chronic gastric inflammation that can progress to atrophy and gastric adenocarcinoma. Polarization of macrophages is a characteristic of both cancer and infection, and may promote progression or resolution of disease. However, the role of macrophages and their polarization during H. pylori infection has not been well defined. Methodology/Principal Findings By using a mouse model of infection and gastric biopsies from 29 individuals, we ...
Sakagami, T; Dixon, M; O'Rourke, J; Howlett, R.; Alderuccio, F; Vella, J; Shimoyama, T; Lee, A.
BACKGROUND/AIMS: The role of host factors has been neglected in studies of the pathogenesis of Helicobacter associated disease. The aim of this study was to assess the response of different mouse strains to infection with a single strain of Helicobacter felis. METHOD: Six strains of inbred mice were infected with the identical H felis culture and were killed at one month, two months, and six months after infection to assess histopathological changes. In addition, two strains of mice were infe...
Corpus-based translation studies belong to a new translation study paradigm which rose at the beginning of 1990s. The rise of corpus brings the update of research tools and research methods, and lead to the emerging of Corpus Translation Stud-ies. It is necessary to introduce the theory basis of Translational English Corpus and its application in the translation, especially in the science and technology translation. Besides, it makes an analysis and discussion about the potential of Corpus Translation Stud-ies.
In a retrospective review of biphasic upper gastrointestinal (GI) tract examinations in 300 consecutive patients with abdominal pain, blood loss, nausea and vomiting, weight loss or dysphagia, the author evaluated the frequency of radiographic findings suggestive of gastritis. Forty-eight patients had undergone endoscopy within 1 week of upper GI tract examination. ''Best findings'' were defined by receiver operating characteristic wave analysis of individual findings, including aphthous lesions, serrated or nodular folds, marginal spiculation, and luminal constriction. Most false negative studies were in the fundus or proximal body; most false positive studies were in the antrum. They present a pictorial dictionary of findings and data for use of ''best findings'' to improve sensitivity and specificity in the diagnosis of gastritis
Marjanović, Ksenija; Dovhanj, Jasna; Kljaić, Ksenija; Šakić, Katarina; Kondža, Goran; Tadžić, Refmir; Včev, Aleksandar
Oxidative stress occurs in inflammation of gastric mucosa. The role of zinc in modulating oxidative stress has recently been recognized. Zn deficiency results in an increased sensitivity to oxidative stress and have a higher risk of musoca damage in inflammation. The aim of this study was to determine wheather chronic inflammation affects on the concentration of Zn2+ ions in gastric mucosa of patients with chronic gastritis. Forthy-three patients with chronic gastitis were enrolled. Patients ...
Jo, Yong Min; Jang, Jin Seok; Han, Seung Hee; Kang, Sang Hyun; Kim, Woo Jae; Jeong, Jin Sook
Eosinophilic gastroenteritis is very rare disorder that is characterized by eosinophilic infiltration of the gastrointestinal tract in the absence of any definite causes of eosinophilia. It is associated with various clinical gastrointestinal manifestations, and depends on the involved layer and site. We report a case of eosinophilic gastritis presenting with severe necrosis. The symptoms disappeared immediately after beginning steroid treatment, and the eosinophil count decreased to the refe...
Even though Ga-67 imaging has been used widely in the diagnosis of malignant as well as inflammatory lesions, its uptake in the stomach has been reported in the literature mainly in gastric lymphoma and carcinoma. As shown in this case, intense gastric uptake of the radionuclide may be seen in common gastritis without malignancy. Perhaps the benign gastric uptake of Ga-67 deserves more emphasis
Full Text Available Problem statement: The growth in the number of documents written in Malay language is enormously available on the web and intranets. There is a need to identify the information in the Malay documents that contain knowledge. This triggers the need to investigate the availability of knowledge in them. Approach: This study uses interrogative theory to identify knowledge from documents or texts. Results: The results are expected to lead towards establishment of new set of interrogative rules for Malay corpus. Conclusions/Recommendations: This study contributes the interrogative knowledge identification thru the development of Malay Interrogative Knowledge Corpus (MalayIKCorpus. It facilitates to explicitly capture and make available Malay knowledge representation in a knowledge-base system.
Schäfer, Roland; Barbaresi, Adrien; Bildhauer, Felix
International audience In web corpus construction, crawling is a necessary step, and it is probably the most costly of all, because it requires expensive bandwidth usage, and excess crawling increases storage requirements. Excess crawling results from the fact that the web contains a lot of redundant content (duplicates and near-duplicates), as well as other material not suitable or desirable for inclusion in web corpora or web indexes (for example, pages with little text or virtually no t...
Full Text Available Management of breast cancer includes systematic therapies including chemotherapy and endocrine therapy can lead to a variety of symptoms that can impair the quality of life of many breast cancer survivors. Atrophic vaginitis, caused by decreased levels of circulating estrogen to urinary and vaginal receptors, is commonly experienced by this group. Chemotherapy induced ovarian failure and endocrine therapies including aromatase inhibitors and selective estrogen receptor modulators can trigger the onset of atrophic vaginitis or exacerbate existing symptoms. Symptoms of atrophic vaginitis include vaginal dryness, dyspareunia, and irritation of genital skin, pruritus, burning, vaginal discharge, and soreness. The diagnosis of atrophic vaginitis is confirmed through patient-reported symptoms and gynecological examination of external structures, introitus, and vaginal mucosa. Lifestyle modifications can be helpful but are usually insufficient to significantly improve symptoms. Non-hormonal vaginal therapies may provide additional relief by increasing vaginal moisture and fluid. Systemic estrogen therapy is contraindicated in breast cancer survivors. Continued investigations of various treatments for atrophic vaginitis are necessary. Local estrogen-based therapies, DHEA, testosterone, and pH-balanced gels continue to be evaluated in ongoing studies. Definitive results are needed pertaining to the safety of topical estrogens in breast cancer survivors.
Gobbo, Alessandro Del; Elli, Luca; Braidotti, Paola; Nuovo, Franca Di; Bosari, Silvano; Romagnoli, Solange
Russell body gastritis is an unusual form of chronic gastritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic inclusions. Very few cases have been reported in the literature; the majority of which have shown Helicobacter Pylori (H. pylori) infection, thus suggesting a correlation between plasma cell presence and antigenic stimulation by H. pylori. We present a case of Russell body gastritis in a 78-year-old woman who was undergoing eso...
Sugano, Kentaro; Tack, Jan; Kuipers, Ernst J.; David Y Graham; El-Omar, Emad M.; Miura, Soichiro; Haruma, Ken; Asaka, Masahiro; Uemura, Naomi; Malfertheiner, Peter
Objective To present results of the Kyoto Global Consensus Meeting, which was convened to develop global consensus on (1) classification of chronic gastritis and duodenitis, (2) clinical distinction of dyspepsia caused by Helicobacter pylori from functional dyspepsia, (3) appropriate diagnostic assessment of gastritis and (4) when, whom and how to treat H. pylori gastritis. Design Twenty-three clinical questions addressing the above-mentioned four domains were drafted for which expert panels ...
Tatsuta, M.; Iishi, H.; Okuda, S
Gastric emptying was compared in patients with gastric cancers and fundal gastritis to determine its value in identifying patients at high risk of gastric cancer. Gastric emptying was measured by the acetaminophen absorption method, and the extent of fundal gastritis was determined by the endoscopic Congo red test. The results showed that gastric emptying was significantly slower in patients with severe fundal gastritis than in those without. Gastric emptying in patients with differentiated a...
Raut, Shrikant C.; Patil, Vinayak W; Dalvi, Shubhangi M; Bakhshi, Girish D.
Helicobacter pylori are considered the most common human pathogen colonizing gastric mucosa. Gastritis with or without H. pylori infection is associated with increase in levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP) but a more pronounced increase is noted in gastritis with H. pylori infection. Increasing level of homocysteine, due to decreased absorption of vitamin B12 and folic acid, together with increased CRP levels in gastritis with H. pylori infection may be the...
Chuan Zhang; Nobutaka Yamada; Yun-Lin Wu; Min Wen; Takeshi Matsuhisa; Norio Matsukura
AIM: To compare Helicobacter pyloriinfection and gastric mucosal histological features of gastric ulcer patients with chronic gastritis patients in different age groups and from different biopsy sites.METHODS: The biopsy specimens were taken from the antrum, corpus and upper angulus of gastric ulcer and chronic gastritis patients. Giemsa staining, improved Toluidine-blue staining and H pylori-specific antibody immune staining were performed as appropriate for the histological diagnosis of H pylori infection. Hematoxylineosin staining was used for the histological diagnosis of activity of H pylori infection, mucosal inflammation,glandular atrophy and intestinal metaplasia and scored into four grades according to the Updated Sydney System.RESULTS: Total rate of H pylori infection, mucosal inflammation, activity of H pylori infection, glandular atrophy and intestinal metaplasia in 3 839 gastric ulcer patients (78.5%, 97.4%, 82.1%, 61.1% and 64.2%,respectively) were significantly higher than those in 4 102chronic gastritis patients (55.0%, 90.3%, 56.2%, 36.8%,and 37.0%, respectively, P＜0.05). The rate of H pylori colonization of chronic gastritis in ＜30 years, 31-40 years,41-50 years, 51-60 years, 61-70 years and ＞70 years age groups in antrum was 33.3%, 41.7%, 53.6%, 57.3%,50.7%, 43.5%, respectively; in corpus, it was 32.6%,41.9%, 53.8%, 60.2%, 58.0%, 54.8%, respectively; in angulus, it was 32.4%, 42.1%, 51.6%, 54.5%, 49.7%,43.5%, respectively. The rate of Hpyloricolonization of gastric ulcer in ＜30 years, 31-40 years, 41-50 years,51-60 years, 61-70 years and ＞70 years age groups in antrum was 60.5%, 79.9%, 80.9%, 66.8%, 59.6%, 45.6%,respectively; in corpus, it was 59.7%, 79.6%, 83.6%,80.1%, 70.6%, 59.1%, respectively; in angulus, it was61.3%, 77.8%, 75.3%, 68.8%, 59.7%, 45.8%,respectively. The rate of H pylori colonization at antrum was similar to corpus and angulus in patients, below50 years, with chronic gastritis and in patients, below40 years, with
Lynch, D A; Mapstone, N P; Clarke, A. M.; Jackson, P.; Dixon, M F; Quirke, P; Axon, A T
Patients who have undergone gastric resection are at higher risk of developing gastric carcinoma than normal subjects, and bile reflux is believed to play a role in carcinogenesis. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging, particularly where there is chronic epithelial injury associated with bile reflux. Helicobacter pylori is considered a major risk factor for gastric cancer in the intact stomach. It has been shown ...
In this article I discuss the role of translated texts in different types of corpora. I first consider the role of translations in corpus-based monolingual linguistics, arguing that while translated texts are often excluded from corpora on the basis of a more or less implicit assumption that they “corrupt” the reference norm for a language, this assumption does not seem to be justified on theoretical grounds. For the same reason, translated texts should also be included in bi- and multi-lingu...
目的：探讨幽门螺杆菌(Hp)感染与慢性胃炎、消化性溃疡的关系。方法：收治胃镜检查确诊的慢性胃炎、消化性溃疡患者151例，包括慢性浅表性胃炎、慢性糜烂性胃炎、慢性萎缩性胃炎、胆汁反流性胃炎以及胃和十二指肠溃疡，分别给予胃黏膜组织活检及快速尿素酶试验检查Hp感染情况，分析炎性反应情况与Hp感染的关系。结果：慢性萎缩性胃炎37例，Hp感染阳性率86.48%；慢性糜烂性胃炎36例，Hp感染阳性率80.56%；慢性浅表性胃炎26例，Hp感染阳性率65.38%；胆汁反流性胃炎22例，Hp感染阳性率36.36%，消化性溃疡30例，Hp感染阳性率80.00%。慢性萎缩性胃炎阳性率最高，胆汁反流性胃炎阳性率最低，差异具有统计学意义(P＜0.05)。结论：几种常见的慢性胃炎、消化性溃疡均伴有不同程度Hp的感染，不同胃炎、消化性溃疡中Hp感染率差异具有统计学意义。慢性糜烂性胃炎、慢性萎缩性胃炎以及消化性溃疡感染Hp明显高于正常人群，从而提出Hp感染是产生的重要致病因素。%Objective:To investigate the relationship between helicobacter pylori(Hp) infection with chronic gastritis and peptic ulcer.Methods:151 patients with chronic gastritis or peptic ulcer were selected,including chronic superficial gastritis,chronic erosive gastritis,chronic atrophic gastritis,bile reflux gastritis,gastric and duodenal ulcer.All of those patients were treated with gastric mucosal biopsy and rapid urease test to detected helicobacter pylori infection,then we analyzed the relationship between inflammatory response and Hp infection.Results:37 cases were with chronic atrophic gastritis,and the positive rate of Hp infection was 86.48%;36 cases were chronic erosive gastritis,and the positive rate was 80.56%;26 cases were chronic superficial gastritis, and the positive rate was 65.38%;22 cases were bile reflux gastritis,and the positive rate
Full Text Available Objective To analyze the clinical and pathological features of primary bile reflux gastritis(BRG.Methods Endoscopy,Helicobacter pylori(H.pylori detection,and histopathologic examination were performed in 218 patients with primary BRG(observed group and 236 patients with simple chronic gastritis(SCG,control group as identified by gastroscope in order to analyze the endoscopic abnormalities,the frequency of H.pylori infection,pathological features and scores of inflammation.Results The frequency of H.pylori infection was 39.0%(85/218 in the observed group,which was significantly lower than that in the control group [52.1%(123/236].The topographic abnormalities of the antral mucosa as detected by gastroscopy,i.e.,congestion,hemorrhagic spots,erosion were not significantly different between BRG and SCG patients(P > 0.05.The scores of chronic and active inflammation were higher in patients when H.pylori infection was present than in patients without H.pylori infection in both groups(P < 0.05.The scores of inflammation,the detection rates of the antral intestinal metaplasia,antral atrophy and atypical hyperplasia were all higher in observed group than in control group(P < 0.05.The incidence of lengthening of gastric pits,telangiectasis or interstitial edema in BRG patients was also significantly higher than those in SCG patients(P < 0.05.Conclusions Primary BRG shows features of chemical gastritis with a higher tendency toward mucosal atrophy,intestinal metaplasia and atypical hyperplasia.Gastropic examination and biopsy should be emphasized.
SEVİNÇ, Eylem; ARSLAN, Duran; , Haluk AKAR
Cow's milk protein allergy is frequently seen in infancy. Its findings can be diverse, including different histopathological involvement ranging from a superficial to hemorrhagic gastritis. Children presenting with resistant emesis, hematemesis and hemorrhagic gastritis should be investigated for cow's milk allergy. Endoscopy and biopsy are important in the diagnosis.
In this article, we propose an automatic process to build multi-lingual lexico-semantic resources. The goal of these resources is to browse semantically textual information contained in texts of different languages. This method uses a mathematical model called Atlas s\\'emantiques in order to represent the different senses of each word. It uses the linguistic relations between words to create graphs that are projected into a semantic space. These projections constitute semantic maps that denote the sense trends of each given word. This model is fed with syntactic relations between words extracted from a corpus. Therefore, the lexico-semantic resource produced describes all the words and all their meanings observed in the corpus. The sense trends are expressed by syntactic contexts, typical for a given meaning. The link between each sense trend and the utterances used to build the sense trend are also stored in an index. Thus all the instances of a word in a particular sense are linked and can be browsed easily...
尹光耀; 张武宁; 沈小静; 何雪芬; 陈一
Background Spleen in Traditional Chinese Medicine (TCM) is not actually the spleen in the anatomic sense designated in western medicine because its functions basically belong to the physiological category of digestive system in modern medicine, and it represents a macroscopic concept of digestion, absorption and nutrition metabolism. Spleen deficiency syndrome refers to the clinical phenomena such as hypofunction of digestion, absorption and nutrition metabolism. By integrating TCM with modern medicine , this paper is intended to explore the pathological basis of classification of spleen deficiency in chronic gastritis.Method By means of optical microscope, scanning electron microscope (SEM), transmission electron microscope (TEM) and histochemical staining, we conducted histopathological and subcellular ultrastructural (nuclei and mitochondrial) analysis of gastric mucosa of 188 patients of spleen deficiency, and that of 42 voluntary blood donors without clinical symptoms. Results The gastric mucosa of patients with spleen Qi deficiency (SQD) and spleen yang deficiency (SyangD) could either be affected by organic lesion (type G-occurring on the basis of chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG)) or unaffected (type F-chiefly belonging to functional indigestion); spleen yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS) both occurred on the basis of CSG and CAG; and the degree of mucosa inflammatory cells infiltration, the degree of decrease in glands propria, and the incidence of IMⅡb in CSG and CAG were more serious than those of G-SQD and G-SyangD, P<0.05-0.01.Conclusion Spleen deficiency syndrome is likely to occur on the basis of organic lesion of gastric mucosa (disease with symptoms of both CSG or CAG and spleen deficiency symptoms), as well as on the basis of inorganic lesion of gastric mucosa (nondisease with symptoms, which is, despite spleen deficiency symptoms, there is no CSG or CAG). Besides, the
YIN Guang-yao; CHEN Yi; SHEN Xiao-jing; HE Xue-fen; ZHANG Wu-ning
Background Most of the studies on traditional Chinese medicine (TCM)‘spleen’deficiency syndrome in the recent 30 years were conducted only on the basis of single functional index, neglecting the study on the pathophysiologic internal relationship between spleen deficiency syndrome and gastric diseases in modern medicine. But it was at the subcellular molecular biological level that we explored the pathophysiologic basis of classification of spleen deficiency in chronic gastritis by detecting the bioactive substances in gastric mucosa nuclei and mitochondria. Methods By means of optical microscope, scanning electron microscope (SEM), transmission electron microscopy (TEM) and histochemical staining, we conducted histopathological, subcellular ultrastructural analysis and nuclei and mitochondrial ultrastructural analysis of gastric mucosa of 188 spleen deficiency patients and of 42 voluntary blood donors. At the same time, bioactive substances were measured by means of X-ray energy dispersive analysis system (EDAX) image analysis system, radioimmunoassay method and chemiluminescence method. Results The content of cAMP, superoxide dismutase (SOD), Zn and Cu in gastric mucosa, and the content of Zn and Cu in mitochondria decreased progressively in order of groups: healthy control (HC), spleen Qi deficiency without organic lesion (F-SQD), spleen Yang deficiency without organic lesion (F-SyangD), disease without symptoms group, spleen Qi deficiency with organic lesion (G-SQD), spleen Yang deficiency with organic lesion (G-SyangD), spleen Yin deficiency (SyinD) and spleen deficiency with Qi stagnation (SDQS), chronic spleen deficiency gastritis (CSG) and chronic atrophic gastritis (CAG); decreased in order of HC, intestinal metaplasia (IM)Ⅰa, IMⅠb, IMⅡa and IMⅡb, P<0.05. The content of DNA, Zn and Cu in nuclei progressively increased in order mentioned above, P<0.05.Conclusions The quantitative changes of gastric mucosal cAMP, SOD, Zn, Cu, of mitochondrial Zn
A chronic gastritis is common and clinically significant, but specific findings were rarely described in UGIS. And the authors attempted to clarify the area gastrica of the stomach related to the chronic gastritis. The authors reviewed 'Areae gastricae' micromucosal patterns of stomach, retrospectively with double contrast barium meal study in 16 cases, histologically proven cases of chronic gastritis by endoscopic biopsy from January 1, 1980 to June 30, 1980. Here the commonest site of chronic gastritis is evident in 12 cases in pyloric gland area, and a sixe of area gastrica shows above 2.5mm in longest diameter with combinding morphology, regular to irregular, 3 to 1 and coarse barium accumulations of intervening sulci. The chronic gastritis could be suggested with this better technique of UGIS
Hession, Meghan T.; Graber, Emmy M.
Background: Scarring is an unfortunate and frequent complication of acne, resulting in significant psychological distress for patients. Fortunately, numerous treatment options exist for acne scarring. Objectives: To extensively review the literature on treatment options for atrophic acne scarring. Materials and methods: A comprehensive literature search was conducted on the following topics: dermabrasion, subcision, punch techniques, chemical peels, tissue augmentation, and lasers. Results: T...
A series of 602 patients are studied according to a standard protocol including double contrast examination, taking films with dosed compression and complete filling (accordingly 3+3+1 radiographs). A barium suspension at concentration 200.0 BaSO4 in 100 ml water is used as a positive contrast medium, and effervescent powder or pills - as a negative contrast. Erosive gastritis is diagnosed in 48 patients (7.9%) of which 38 present complete erosions (79.2%), 6 (12.6%) - incomplete, and 4 (8.3%) - mixed erosions. In 35 cases (72.9%) erosions are differentiated in double-contrast films, while in 21 (43.8%) - in those with compression. The advantage of the double contrast technique consists in visualization of erosions of the body of the stomach and discovering of incomplete erosions. In 483 patients a comparative assessment is done of the X-ray and endoscopic findings. There are recorded 5 false-positive and 25 false-negative radiological results. The sensitivity of the X-ray study in terms of erosive gastritis amounts to 59.7%. 15 refs., 4 figs. (orig.)
The originator and founder of hermetism was the mythical Hermes Trismegistos, a deity of the syncretic Hellenistic religion that came into being through the identification of the Greek god Hermes with the Egyptian god Thot. In later Hellenistsic times various hermetic writers considered Hermes Trismegistos to have been a historical personage, a king, prophet and philosopher (physician), as well as author of many widely disseminated writings that made up the so-called Corpus Hermeticum (eighteen separate treatises from the 2nd-4th centuries AD) and the so-called Emerald Table (Tabula Smaragdina). The Corpus Hermeticum is a collection of treatises of a philosophical, religious, theological as well as theosophical nature. The collection played an important role in the development of the philosophy of alchemy and hermetism, and formed the basis for an alchemist philosophy of nature. There are currently two views among scholars on the origins of hermetism. According to one, hermetism derived directly from Egypt, while according to the other it orginated in Greece. In the years 1945-46 a number of hermetic texts forming part of the now famous gnostic "library" were discovered in Nag-Hammadi (Chenosboskion) in Upper Egypt. The Coptic texts from Nag-Hammadi date from the middle of the 4th century AD, and according to experts are translations from the Greek. Some authors (R. Reitzenstein and T. Zieliński) have suggested that along with the appearance in Egypt of the Hermetic Books, attributed to Hermes Trismegistos, there also appeared a new god in Egypt, Poimandres, and a new religion was established, hermetism, which competed for influence with Christianity. The present article discusses the main of the hermetic treatises, including Poimandres, which contains an account of the creation of the world. The article also discusses the reasons for the decline of hermetism as a religion and stresses that in spite of this decline the doctrine managed to survive in the form of
Scherfig, Erik Christian Høegh
oftalmology, biopsy, choroid, corpus vitreum, retina, malignant melanoma, biopsy technic, retinoblastoma......oftalmology, biopsy, choroid, corpus vitreum, retina, malignant melanoma, biopsy technic, retinoblastoma...
Zhu Hui-wen; Ruan Chun-xun; Cao Shu-fei; Wu Huan-gan; Li Jing
By computer research, the literature of clinical and experimental studies on moxibustion therapy for chronic gastritis in the recent fifteen years was collected, sorted and analyzed, in order to understand the general situation about the clinical and experimental studies on moxibustion therapy for chronic gastritis, summarize the regularity of moxibustion therapy for chronic gastritis, so as to guide the treatment of chronic gastritis.
Jaiganesh S, Venkateshwaran A, Naresh Kumar C, Rajasekhar KV
Full Text Available Isolated complete corpus callosal agenesis is a rare entity. Usually this condition will be an associated finding in other syndromes. 3 month old male child came with complaints of deformed foot on both sides, not having a social smile and neck holding. Patient referred to the Radiology department for MRI brain which showed complete absence of corpus callosum, widely separated and parallely placed lateral ventricles, colpocephaly, high riding of 3rd ventricle and absence of cingulate gyrus and radial arrangement of gyri along the interhemispheric fissure. Hence it was reported as isolated complete corpus callosal agenesis and this article describes the Embryogenesis, anatomy, developmental anomalies and its clinical manifestations & prognosis.
Yi-Hui Luo; Jie Yan; Ya-Fei Mao
that of the patients with atrophic gastritis (3/10, 30.0%)(X2=7.50-9.66, P＜0.01).CONCLUSION: The biological activities of H-LPS were weaker than those of E-LPS, the activities of H-LPS of lowering rabbit blood pressure and inducing rabbit PBMC were relatively stronger. H-LPS may play a critical role in inducing inflammatory reaction in human gastritis.
Gastritis cystica polyposa is an uncommon benign lesion that normally occurs on the gastric side of a gastroenterostomy site but is rarely found in patients without a prior history of stomach surgery. We report a case of a 41-year-old woman with gastrodeuodenal intussusception due to gastritis cystica polyposa that developed in an unoperated stomach. CT revealed gastroduodenal intussusception and a cystic and solid mass with fat density in the second portion of the duodenum. Surgery and a pathologic examination confirmed gastritis cystica polyposa.
Kwak, Soon Hyuk; Bae, Il Hun; Park, Kil Sun; Lee, Seung Young; Jeon, Min Hee; Cho, Bum Sang; Kamg, Min Ho [Dept. of Radilogy, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of); Ryu, Dong Hee [Dept. of Surergy, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of); Lee, Ho Chang [Dept. of Pathology, College of Medicine and Medical Research Institute, Chonbuk National University, Chonju (Korea, Republic of)
Gastritis cystica polyposa is an uncommon benign lesion that normally occurs on the gastric side of a gastroenterostomy site but is rarely found in patients without a prior history of stomach surgery. We report a case of a 41-year-old woman with gastrodeuodenal intussusception due to gastritis cystica polyposa that developed in an unoperated stomach. CT revealed gastroduodenal intussusception and a cystic and solid mass with fat density in the second portion of the duodenum. Surgery and a pathologic examination confirmed gastritis cystica polyposa.
Mäkinen, Johanna M; Niemelä, Seppo; Kerola, Tuomo; Lehtola, Juhani; Karttunen, Tuomo J
AIM: Lymphocytic gastritis is commonly associated with Helicobacter pylori infection. The presence of glandular atrophy and foveolar hyperplasia in lymphocytic gastritis suggests abnormalities in cell proliferation and differentiation, forming a potential link with the suspected association with gastric cancer. Our aim was to compare epithelial proliferation and morphology in H pylori associated lymphocytic gastritis and H pylori gastritis without features of lymphocytic gastritis, and to eva...
Davis, Michael S.; Williamson, Katherine K.
Gastritis and gastric ulcers are an important cause of morbidity and mortality in canine athletes. Although the majority of scientific work on this condition has been performed in ultraendurance racing sled dogs, this condition has been identified in other canine athletes, including sled dogs competing in shorter events and dogs performing off-leash explosive detection duties. The cause of the syndrome is unknown, but current hypotheses propose a link between exercise-induced hyperthermia and loss of gastric mucosal barrier function as an early event in the pathogenesis. Treatment is focused on prevention of clinical disease using acid secretion inhibitors, such as omeprazole, which has excellent efficacy in controlled clinical studies. PMID:27092307
Gerald O’Daniel, T.
Atrophic facial acne scarring is a widely prevalent condition that can have a negative impact on a patient’s quality of life. The appearance of these scars is often worsened by the normal effects of aging. A number of options are available for the treatment of acne scarring, including chemical peeling, dermabrasion, ablative or nonablative laser resurfacing, dermal fillers, and surgical techniques such as subcision or punch excision. Depending on the type and extent of scarring, a multimodal ...
Theodoridis Athanasios; Makrantonaki Evgenia; Zouboulis Christos C
Abstract Definition of the disease Malignant atrophic papulosis (MAP), described independently by Köhlmeier and Degos et al., is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and surrounding teleangiectatic rim. Epidemiology Less than 200 cases have been described in the literature. The first manifestation of MAP usually occurs between the 20th and 50th year of life. Clinical description The cutaneous clinical pic...
Full Text Available Dermal grafting is a valuable technique in the field of dermatosurgery for the treatment of atrophic scars where the source of filler material is the patient′s own dermis. However, it is underused for the reasons being difficulties in placing the graft in the tunnel, keratin cysts and complications due to biofilms. Railroading technique used in urology for rupture urethra has been described for dermal grafts to overcome the technical difficulties of graft placement.
Full Text Available Background: Atrophic facial scars are always a challenge to treat, especially the ones that are deep-seated and/or involve much of the face. Microneedling or dermaroller therapy is a new addition to the treatment armamentarium for such scars that offers a simple and reportedly effective management of these scars. Aims: The aim of the present study was to perform an objective evaluation of the efficacy of dermaroller treatment in atrophic facial scars of varying etiology. Materials and Methods: Thirty-seven patients of atrophic facial scarring were offered multiple sittings of microneedling (dermaroller treatment and their scars were evaluated and graded clinically and by serial photography at the start as well as at two months after the conclusion of the treatment protocol. Any change in the grading of scars after the end of treatment and follow-up period was noted down. The patients were also asked to evaluate the effectiveness of the treatment received on a 1-10 point scale. The efficacy of dermaroller treatment was thus assessed both subjectively by the patients as well as objectively by a single observer. Results: Overall 36 out of the total of 37 patients completed the treatment schedule and were evaluated for its efficacy. Out of these 36 patients, 34 achieved a reduction in the severity of their scarring by one or two grades. More than 80% of patients assessed their treatment as ′excellent′ on a 10-point scale. No significant adverse effects were noted in any patient. Conclusions: Microneedling therapy seems to be a simple and effective treatment option for the management of atrophic facial scars.
El-Domyati, Moetaz; Barakat, Manal; Awad, Sherif; Medhat, Walid; El-Fakahany, Hasan; Farag, Hanna
Objective: Treatment of acne scarring is always a challenge. Microneedling therapy or percutaneous collagen induction is a new addition to the treatment modalities for such scars and has been reported to be simple and effective in atrophic acne scar treatment. The aim of this study is to evaluate the clinical effect and objectively quantify the histological changes of acne scarring in response to skin microneedling. Design: A prospective clinical study. Participants: Ten patients with differe...
Zhang, Chuan; Yamada, Nobutaka; Wu, Yun-Lin; Wen, Min; Matsuhisa, Takeshi; Matsukura, Norio
AIM: To evaluate the histological features of gastric mucosa, including Helicobacter pylori infection in patients with early gastric cancer and endoscopically found superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer.
Luis Eduardo Bravo
Full Text Available Introduction: Multiple sampling from different sites of the stomach as well as the number of fragments of gastric mucosa available for histopathologic evaluation are important sources of variation when classifying and grading chronic gastritis. Objective: To estimate the sensitivity of the number of fragments of gastric mucosa necessary to establish the diagnosis of atrophic gastritis with intestinal metaplasia, gastric dysplasia and H. pylori infection. In addition, this study will attempt to assess the intra-observer variability in the classification of these premalignant gastric lesions. Methods: This is a 6 year-cohort study, wherein 1958 gastric endoscopic procedures performed by two gastroenterologists were reviewed. Five gastric biopsy samples were obtained from the antrum, body and lesser curvature during each procedure. One pathologist was in charge of reviewing the five histopathology samples for each subject and providing a definitive diagnosis which was used as the gold standard. Each gastric mucosa sample reviewed led to an individual diagnosis for that sample which was compared with the gold standard. Intra-observer variability was assessed in 127 individuals who correspond to a random sample of 20% of the total endoscopic procedures performed during the 72 month-follow-up. Results: The sensitivity of the diagnosis of intestinal metaplasia (IM and gastric dysplasia increased proportionally with the number of gastric mucosa samples reviewed. The lesser curvature of the stomach had the highest sensitivity for the diagnosis of IM and dysplasia, among all the stomach regions studied. Just one sample of gastric mucosa attained a sensitivity of 95.9% for the detection of H. pylori infection. The intra-observer agreement for the diagnosis of multifocal atrophic gastritis was 86.1% and the kappa value was 0.79 (95% CI 0.76-0.85. Alcohol-fixed biopsy specimens were inadequate to diagnose H. pylori infection and to assess dysplasia
Bungeroth, Jan; Stein, Daniel; Dreuw, Philippe; Ney, Hermann; Morrissey, Sara; Way, Andy; van Zijl, Lynette
Systems that automatically process sign language rely on appropriate data. We therefore present the ATIS sign language corpus that is based on the domain of air travel information. It is available for five languages, English, German, Irish sign language, German sign language and South African sign language. The corpus can be used for different tasks like automatic statistical translation and automatic sign language recognition and it allows the specific modelling of spatial references in sign...
Full Text Available Background: Atrophic acne scars are difficult to treat. The demand for less invasive but highly effective treatment for scars is growing. Objective: To assess the efficacy of combination therapy using subcision, microneedling and 15% trichloroacetic acid (TCA peel in the management of atrophic scars. Materials and Methods: Fifty patients with atrophic acne scars were graded using Goodman and Baron Qualitative grading. After subcision, dermaroller and 15% TCA peel were performed alternatively at 2-weeks interval for a total of 6 sessions of each. Grading of acne scar photographs was done pretreatment and 1 month after last procedure. Patients own evaluation of improvement was assessed. Results: Out of 16 patients with Grade 4 scars, 10 (62.5% patients improved to Grade 2 and 6 (37.5% patients improved to Grade 3 scars. Out of 22 patients with Grade 3 scars, 5 (22.7% patients were left with no scars, 2 (9.1% patients improved to Grade 1and 15 (68.2% patients improved to Grade 2. All 11 (100% patients with Grade 2 scars were left with no scars. There was high level of patient satisfaction. Conclusion: This combination has shown good results in treating not only Grade 2 but also severe Grade 4 and 3 scars.
... disclaimer . Subscribe Gut Feelings About Gastritis When Your Stomach’s Sick Your stomach lining has an important job. It makes acid ... pain or an uncomfortable feeling in their upper stomach. But many other conditions can cause these symptoms. ...
We present a case of emphysematous gastritis initially detected with 111In oxine-labeled white blood cell scintigraphy and subsequently confirmed by computed tomography. Early aggressive antibiotic and supportive therapy resulted in a successful clinical outcome
Miettinen, A.; Karttunen, T J; Alavaikko, M.
Lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. It has recently been suggested that Helicobacter pylori has a role in the pathogenesis of both of them. The occurrence of lymphocytic gastritis and H pylori was studied in a series of patients with primary gastric lymphoma. The cases of primary gastric lymphomas (n = 35) diagnosed in years 1970-1993 were identified. The specimens of 22 cases contained gastric mucosa sufficiently so that the number o...
S. Kazem Nezam
Full Text Available Background: Bile gastritis (gastropathy is a kind of gastritis which is caused by reflux of bile contents through duodenum on stomach. It can occur spontaneously without any former gastric surgeries which affect sphincter of pylorus. The positive impact of some certain drugs such as prokinetic agents e.g. metoclopramide, Proton-pump inhibitors (PPIs, cholestyramine and sucralfate in treating bile gastritis has been confirmed. This study has been conducted in order to analyze the effect of ursodeoxycholic acid (UDCA, which is a harmless drug, on patients with the bile gastritis. Materials and Methods: In this clinical trial, all patients with dyspepsia who were qualified to undertake endoscopy were enrolled and then 60 patients with bile gastritis were selected for the study. The patients were divided into two groups; a group was treated by UDCA, omeprazole and sucralfate and another one was treated with placebo, omeprazole and sucralfate for two weeks. Finally, at the end of the third week of treatment patients were examined.Results: A total of sixty 19-70 year-old patients (Mean: 46 years old included in this study. At the end of the study, there was not found any meaningful difference between the two groups in terms of pain intensity, heartburn intensity, severity of bloating, vomiting and early satiety; however, each group independently showed improvement of the mentioned indices after termination of the treatment (p=0.0005.Conclusion: Adding UDCA to the standard treatment (sucralfate is not clinically effective in curing the bile gastritis.
Zun Xiang; Jian-Min Si; Huai-De Huang
AIM: To establish an experimental animal model of chronic gastritis in a short term and to investigate the effects of several potential inflammation-inducing factors on rat gastric mucosa.METHODS: Twenty-four healthy, male SD rats were treated with intragastric administration of 600 mL/L alcohol, 20mmol/L sodium deoxycholate and 0.5 g/L ammonia (factor A), forage containing low levels of vitamins (factor B), and/or indomethacin (factor C), according to an L8(27)orthogonal design. After 12 wk, gastric antral and body mucosae were pathologically examined.RESULTS: Chronic gastritis model was successfully induced in rats treated with factor A for 12 wk. After the treatment of animals, the gastric mucosal inflammation was significantly different from that in controls, and the number of pyloric glands at antrum and parietal cells at body were obviously reduced (P＜0.01). Indomethacin induced gastritis but without atrophy, and short-term vitamin deficiency failed to induce chronic gastritis and gastric atrophy, In addition,indomethacin and vitamin deficiency had no synergistic effect in inducing gastritis with the factor A. No atypical hyperplasia and intestinal metaplasia in the gastric antrum and body were observed in all rats studied.CONCLUSION: Combined intragastric administration of 600 mL/L alcohol, 20 mmol/L sodium deoxycholate and 0.5 g/L ammonia induces chronic gastritis and gastric atrophy in rats. Indomethacin induces chronic gastritis only.The long-term roles of these factors in gastric inflammation and carcinogenesis need to be further elucidated.
Shrikant C. Raut
Full Text Available Helicobacter pylori are considered the most common human pathogen colonizing gastric mucosa. Gastritis with or without H. pylori infection is associated with increase in levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP but a more pronounced increase is noted in gastritis with H. pylori infection. Increasing level of homocysteine, due to decreased absorption of vitamin B12 and folic acid, together with increased CRP levels in gastritis with H. pylori infection may be the earliest event in the process of atherosclerosis and plaque formation. Retrospective study conducted at tertiary care hospital in Mumbai by Department of Biochemistry in association with Department of Surgery. Eighty patients who underwent gastroscopy in view of gastritis were subjected to rapid urease test for diagnosis of H. pylori infection. Vitamin B12, folic acid, homocysteine and hs-CRP were analyzed using chemiluminescence immuno assay. Student’s t-test, Pearson’s correlation and linear regression used for statistical analysis. Patients with H. pylori gastritis had significantly lower levels of vitamin B12 (271.6±101.3 vs 390.6±176.7 pg/mL; P=0.0005, as well as higher levels of homocysteine (17.4±7.4 vs 13.8±7.8 mmol/L; P=0.037 and hs-CRP (2.5±2.9 vs 1.2±1.1 mg/L; P=0.017, than in patients without H. pylori gastritis. However, folic acid showed (8.9±3.2 vs 10.0±3.6 ng/mL; P=0.171 no significant difference. Elevated homocysteine and hs-CRP in H. pylori gastritis may independently induce endothelial dysfunction, leading to cardiovascular pathology.
Full Text Available Despite the central role of the computer in corpus research, programming is generally not seen as a core skill within corpus linguistics. As a consequence, limitations in software for text and corpus analysis slow down the progress of research while analysts often have to rely on third party software or even manual data analysis if no suitable software is available. Apart from software itself, data formats are also of great importance for text processing. But again, many practitioners are not very aware of the options available to them, and thus idiosyncratic text formats often make sharing of resources difficult if not impossible. This article discusses some issues relating to both data and processing which should aid researchers to become more aware of the choices available to them when it comes to using computers in linguistic research. It also describes an easy way towards automating some common text processing tasks that can easily be acquired without knowledge of actual computer programming.
Sixty-eight patients with various types of gastritis, 23 patients with normal stomachs, and four patients with other gastric diseases were examined in a prospective study to assess the sensitivity and specificity of single-contrast (SC) and double-contrast (DC) upper gastrointestinal examinations in the evaluation of gastritis. All patients underwent endoscopy with biopsy followed first by DC and then by SC radiography. The respective sensitivities of SC and DC radiography were 58% and 72% for all examinations and 59% and 77% for adequate examinations only. The respective specificities were 59% and 55% based on all examinations. Useful radiographic features included polypoid defects and erosions detected by both methods, abnormal folds and flattened margins detected by the SC technique, and narrowed lumen and crenulated margins detected by the DC technique. In 93% of all cases, the correct diagnosis was based on two or more of these radiographic features. According to this study, the radiographic sensitivity in the detection of gastritis is reliable only in cases of moderate-to-severe disease and only when based on findings of the DC examination. Neither SC nor DC radiography should be used as the primary screening method for patients with suspected gastritis, and the radiographic diagnosis should be restricted to the terms ''erosive'' or ''nonerosive gastritis.''
McEnery, A. M.; Xiao, R. Z.
The Lancaster Corpus of Mandarin Chinese (LCMC) addresses an increasing need within the research community for a publicly available balanced corpus of Mandarin Chinese. LCMC has been constructed as part of a research project undertaken by the Linguistics Department, Lancaster University. The corpus is designed as a Chinese match of the Freiburg-LOB Corpus of British English (FLOB), and, as such, will provide a valuable resource for contrastive studies between English and Chinese as well as a ...
Full Text Available When the posterior maxilla is atrophic, the reference standard of care would be to perform sinus augmentation with an autologous bone graft through the lateral approach and delayed implant placement. However, placement of short implants with the osteotome sinus floor elevation technique and without graft can be proposed for an efficient treatment of clinical cases with a maxillary residual bone height of 4 to 8 mm. The use of grafting material is recommended only when the residual bone height is ≤4 mm. Indications of the lateral sinus floor elevation are limited to cases with a residual bone height ≤ 2 mm and fused corticals, uncompleted healing of the edentulous site, and absence of flat cortical bone crest or when the patient wishes to wear a removable prosthesis during the healing period. The presented case report illustrates osteotome sinus floor elevation with and without grafting and simultaneous implant placement in extreme conditions: atrophic maxilla, short implant placement, reduced healing time, and single crown rehabilitation. After 6 years, all placed implants were functional with an endosinus bone gain.
Plecháč, Petr; Kolár, Robert
Roč. 2, č. 1 (2015), s. 107-118. ISSN 2346-6901 R&D Projects: GA ČR GAP406/11/1825 Institutional support: RVO:68378068 Keywords : Czech poetry * versification * corpus linguistics * theory of verse Subject RIV: AJ - Letters, Mass-media, Audiovision
Lim, Su-Lin; Canavarro, Claudia; Zaw, Min-Htet; Zhu, Feng; Loke, Wai-Chiong; Chan, Yiong-Huak; Yeoh, Khay-Guan
Helicobacter pylori (HP) is associated with chronic gastritis and gastric cancer, and more than half of the world's population is chronically infected. The aim of this retrospective study was to investigate whether an irregular meal pattern is associated with increased risk of gastritis and HP infection. The study involved 323 subjects, divided into three groups as follows: subjects with HP infection and gastritis, subjects with gastritis, and a control group. Subjects were interviewed on eat...
Valnes, K; Brandtzaeg, P
IgG-mediated immune reactions are probably involved in the maintenance of gastritis and glandular atrophy; the mucosal IgG-subclass pattern may therefore influence the effect of local hypersensitivity mechanisms. In this study the proportions of IgG1-, IgG2-, IgG3-, and IgG4-producing immunocytes were determined by paired immunofluorescence staining in specimens from simple gastritis, gastritis after Billroth II (BII) resection, and gastritis associated with dermatitis herpetiformis (DH). The...
Hill, I. D.; Sinclair-Smith, C; Lastovica, A J; Bowie, M D; Emms, M
Three children presented with acute protein losing enteropathy and were found to have acute gastritis associated with Campylobacter pylori infection. Recovery from protein losing enteropathy was accompanied by resolution of the gastritis and the disappearance of C pylori from the gastric mucosa. Their clinical course suggested that the C pylori had caused the gastritis and the protein losing enteropathy. The association between gastritis caused by C pylori and protein losing enteropathy in ch...
Meining, A.; Riedl, B; Stolte, M
Background/Aims: Helicobacter pylori gastritis is a risk factor for the development of gastric cancer. The results of several studies indicate that gastric adenomas, which are considered premalignant lesions, may also be associated with H pylori gastritis. However, it is not clear whether there are different patterns of gastritis in these patients compared with patients with gastric cancer or patients with H pylori gastritis alone. Therefore, this study was designed to investigate the pattern...
Within this decade it has been determined that primary gastritis in both children and adults is frequently associated with infection of the gastric mucosa with Campylobacter pylori. It is characterized by a chronic inflammatory process in which the mucosa of the gastric antrum is typically most severely involved. Other regions of the stomach may be involved and associated peptic ulcers of the stomach and duodenal bulb are frequent. A case of C. pylori gastritis is reported in which involvement of the gastric fundus and body produced severe rugal hypertrophy that resembled Menetrier's disease. (orig.)
Hohwy, Thomas; Jensen, Martin Glümer; Tøttrup, Anders; Steiniche, Torben; Fogh, Karsten
Malignant atrophic papulosis (Degos' disease) is a very rare condition characterized by atrophic papular skin lesions and variable association of systemic involvement. We describe a 33-year-old man who presented with a widespread skin eruption consistent with malignant atrophic papulosis. During...
Marvelis Domínguez Iglesias; Zoila Pérez Rodríguez
Introducción: la gastritis crónica es una de las 40 enfermedades más frecuentes en Cuba, su etiología es multifactorial y el Helicobacter pylori es el agente causal principal. A los campos magnéticos se le reconocen los efectos antiinflamatorios, analgésico, regenerador de tejidos e inhibidor del desarrollo de gérmenes patógenos. Objetivo: evaluar la utilidad de la magnetoterapia en pacientes con gastritis crónica antral. Métodos: se realizó un estudio cuasi-experimental prospectivo en 30 pac...
Taha, A S; Nakshabendi, I.; Lee, F D; Sturrock, R D; Russell, R I
AIMS: To evaluate the prevalence and significance of chemical gastritis, in comparison with gastritis related to Helicobacter pylori in patients receiving non-steroidal anti inflammatory drugs (NSAIDs). METHODS: Two hundred and eighteen patients were studied, 174 of whom were taking NSAIDs. Chemical gastritis was defined as the presence of foveolar hyperplasia, muscle fibres in the lamina propria, oedema and vasodilation, in the absence of a chronic inflammatory cell infiltrate. RESULTS: Chem...
Patients having cerebral atrophic and degenerative changes following hypoglycemia, cerebral contusion, or cerebral hypoxia including cerebrovascular disorders were reported. Description was made as to cerebral changes visualized on CT images and clinical courses of a patient who revived 10 minutes after heart stoppage during neurosurgery, a newborn with asphyxia, a patient with hypoglycemia, a patient who suffered from asphyxia by an accident 10 years before, a patient with carbon monoxide poisoning at an acute stage, a patient who had carbon monoxide poisoning 10 years before, a patient with diffuse cerebral ischemic changes, a patient with cerebral edema around metastatic tumor, a patient with respiration brain, a patient with neurological sequelae after cerebral contusion, a patient who had an operation to excise right parietal lobe artery malformation, and a patient who was shooted by a machine gun and had a lead in the brain for 34 years. (Tsunoda, M.)
Full Text Available Background: Studies suggest that nuclear factor kappa-B (NFκB activation may be a critical event in the production of proinflammatory molecules in Helicobacter pylori-associated gastritis. Materials and Methods: This study examines the expression and activity of NFκB in situ in antral biopsies of 42 consecutive patients with immunohistochemical techniques. Results: NFκB was highly expressed in the gastric epithelial cells. The number of cells showing activated NFκB correlated with the activity of gastritis (P < 0.05, a measure of neutrophil influx, whereas no correlation was found with the chronicity of inflammation, a measure of the presence of mononuclear inflammatory cells. There was also a strong inverse association with the presence and grade of atrophy. Conclusion: This correlation is direct evidence of the importance of NFκB dependent signal transduction for neutrophil influx in gastritis. The role of NFκB appears to be only in the initial stages of gastritis, there is no role for the molecule in the development of chronic inflammation or atrophy.
Ozlem Aydin; Reyhan Egilmez; Tuba Karabacak; Arzu Kanik
Because the presence or absence of H pylori infection has important implications for therapeutic decisions based on histological assessment, the reproducibility of Sydney system is important. The study was designed to test the reproducibility of features of Helicobacter pylori gastritis,using the updated Sydney classification.METHODS: Gastric biopsies of 40 randomly selected cases of Hpylori gastritis were scored semiquantitatively by three pathologists. Variables analysed included chronic inflammation,inflammatory activity, atrophy, intestinal metaplasia, H pylori,surface epithelial damage. Κ values below 0.5 represented poor, those between 0.5 and 0.75 good and values over 0.75excellent interobserver agreement.RESULTS: The best interobserver agreement (κ=0.62) was present for intestinal metaplasia. The agreement was the poorest for evaluating atrophy (κ=0.31).CONCLUSION: Although the results of this study were in accordance with some previous studies, an excellent agreement could not be reached for any features of H pylori gastritis. This low degree of concordance is assumed to be due to the personal evaluation differences in grading the features, the lack of standardized diagnostic criteria, and the ignorance to reach a consensus about the methods to be used in grading the features of H pylori gastritis before initiating the study.
@@ Dr. Zhu Hongming has engaged in TCM internal medicine for more than 40 years and accumulated rich clinical experience, especially in the treatment of diseases of the spleen and stomach. The following is a brief introduction to his experience in TCM differential treatment of chronic gastritis.
Inchul Lee; Hojung Lee; Mijung Kim; Manabu Fukumoto; Shinji Sawada; Shriram Jakate; Victor E. Gould
AIM: To investigate the clinicopathological factors underlying the ethnic differences of Helicobacter pylori gastritis and cancer.METHODS: We analyzed clinicopathological parameters of gastric biopsies having H pylori infection that were randomly selected from different ethnic populations including 147 Americans, 149 Japanese, and 181 Koreans.RESULTS: Males were predominant in Japanese and Korean populations (77.9 and 67.4% respectively) in comparison with Americans (48.3%) (P＜0.001). H pylori gastritis in Koreans and Japanese was characterized by the predominant antral involvement. In the antrum,neutrophilic infiltration into the proliferative zone of pit, i,e.acute foveolitis, was more frequent in Koreans (82%) than in Japanese (71%) (P＜0.05) and Americans (61%) (P＜0.001).Interstitial neutrophilic infiltration, intestinal metaplasia and atrophy were also frequent in Koreans and Japanese. In the body, the prevalence of acute foveolitis was not significantly different among the populations while chronic interstitial inflammation and lymphoid follicles were more pronounced in the body of Americans than in the body of others (P＜0.01).CONCLUSION: The male-, and antrum-predominant Hpylori gastritis in Koreans and Japanese is compatible with the pattern of sex and topographical distribution of gastric cancer incidence. Our data suggest that persistent acute foveolitis at the proliferative zone is a crucial step in the gastric carcinogenesis.
Full Text Available The reconstruction of the atrophic alveolar ridges for implant placement is today a common procedure in dentistry daily practice. The surgical reconstruction provides for the optimization of the supporting bone for the implants and a restoration of the amount of keratinized gingiva for esthetic and functional reasons. In the past, tissue regeneration has been performed with autogenous bone and free gingival or connective tissue grafts. Nowadays, bone substitutes and specific collagen matrix allow for a complete restoration of the atrophic ridge without invasive harvesting procedures. A maxillary reconstruction of an atrophic ridge by means of tissue substitutes and its histological features are then presented.
Maiorana, Carlo; Beretta, Mario; Rancitelli, Davide; Grossi, Giovanni Battista; Cicciù, Marco; Herford, Alan Scott
The reconstruction of the atrophic alveolar ridges for implant placement is today a common procedure in dentistry daily practice. The surgical reconstruction provides for the optimization of the supporting bone for the implants and a restoration of the amount of keratinized gingiva for esthetic and functional reasons. In the past, tissue regeneration has been performed with autogenous bone and free gingival or connective tissue grafts. Nowadays, bone substitutes and specific collagen matrix allow for a complete restoration of the atrophic ridge without invasive harvesting procedures. A maxillary reconstruction of an atrophic ridge by means of tissue substitutes and its histological features are then presented. PMID:27022489
Helicobacter pylori-associated gastritis has been linked to the pathogenesis of gastric adenocarcinoma (GA), especially when assciated with intestinal metaplasia (IM) and atypia/dysplasia (A/D). We examined p53 expression, ploidy and proliferative activity and assessed H.pylori infection in relationship to IM and A/Din case of gastritis not associated with GA and in cases of GA. We examined 53 gastric biopsies from patients with gastritis not associated with GA, including patients with IM and/or A/D (n=35) and with gastritis associated with IM and/or A/D (n=21). Thirty-six distal gastrectomy specimens from patients with GA constituted a third group of patients. A scoring system that encompassed the presence or absence of H.Pylori, degree of gastritis, IM and/or A/D, p53, MIB-1prolefarative index (MPI) and ploidy was estimated in the cases of gastritis and in cancer associated mucosa (CAM) and the adenocarcinoma from patients withGA. Patients with GA had a higher median age than those with gastritis without IM and more were males (ratio 2.2:1). H.pylori was detected in 75% (40/53) of gastritis specimen and in 55% (20/36) of GA cases. There was a statistically significant difference between the incidence of gastritis without IM and/or A/D and CAM (p=0.01). p53 expression was seen in 67% of the cases (14/21) of gastritis with IM and/or A/D and only in 5% (2 cases ) of gastritis without IM (p=0.0005). A statistically significant difference in MPI was seen between CAM and GA (p=0.01) and gastritis without IM and/or A/D and gastritis with IM(p=0.004). Cases of gastritis without IM and/or or A/D has a median score of 8 while cases of gastritis with IM and/or A/D had a median score of 12 (p=0.0003). CAM had a median score of 13, which was significantly different than gastritis without IM and/or A/D(p=0.0003) The presence of IM and/or A/D can be used in H.pylori -associated gastritis as as starting point to further investigate high risk lesions. Those showing p53 expression
Kilgarriff Adam; Pomikálek Jan; Jakubíček Miloš; Whitelock Pete
There are many benefits to using corpora. In order to reap those rewards, how should someone who is setting up a dictionary project proceed? We describe a practical experience of such ‘setting up’ for a new Portuguese-English, English-Portuguese dictionary being written at Oxford University Press. We focus on the Portuguese side, as OUP did not have Portuguese resources prior to the project. We collected a very large (3.5 billion word) corpus from the web, including removing all unwanted mate...
Atrophic acne scarring is an unfortunate, permanent complication of acne vulgaris, which may be associated with significant psychological distress. General dermatologists are frequently presented with the challenge of evaluating and providing treatment recommendations to patients with acne scars. This article reviews a practical, step-by-step approach to evaluating the patient with atrophic acne scars. An algorithm for providing treatment options is presented, along with pitfalls to avoid. A ...
A series of pathological changes of the gastric mucosa such as ulcers hyperplastic polypi and intestinal metaplasias are accompanied with an increased 3H-thymidine incorporation into the mucosa. This disorder of the regulation of DNA synthesis is important as to the diagnosis of stomach cancer, but it is unsuitable as screening test in early recognition
赵晓丹; 孙静晶; 周斌
Objective To discuss the relationship among different TCM syndrome of CAG , relevant pathological changes and Helicobacter pylori infection .Methods 431 CAG patients were divided into 6 kinds of TCM syndromes , i.e.59 cases of liver and stomach qi stagnation syndrome , 35 cases of stagnated heat of liver and stomach syndrome , 168 cases of spleen-stomach deficiency syndrome , 52 cases of spleen-stomach damp heat syndrome , 24 cases of stomach yin deficiency syndrome and 93 cases of stomach merid-ian of blood stasis syndrome .To analysis the relationship among different syndrome , relevant pathological changes and Helicobacter pylori infection .Results (1)In the distribution of different degrees of atrophy , there were statistically significant differences among the six syndromes (P0.05).Conclusion There were correlation among TCM syndromes , pathological changes and Helicobacter pylori infection .%目的：探讨慢性萎缩性胃炎的中医证型分布与胃黏膜病理改变程度、幽门螺杆菌（ H．pylori）感染的相关性。方法将431例慢性萎缩性胃炎患者辨证分为6个证型：肝胃气滞证59例，肝胃郁热证35例，脾胃虚弱证168例，脾胃湿热证52例，胃阴不足证24例，胃络瘀血证93例。分析各证型与胃黏膜病理改变程度、幽门螺杆菌感染的关系。结果（1）各中医证型在不同程度胃粘膜萎缩分布上存在显著性差异（ P＜0．05），其中肝胃气滞证与脾胃虚弱证、胃络瘀血证比较差异均有统计学意义（P＜0．0033）；（2）各中医证型在不同程度肠化生分布上存在显著性差异（P＜0．05），其中，肝胃气滞证与胃络瘀血证比较存在显著性差异（P＜0．0033）；（3）各中医证型在不同程度异型增生分布上差异无显著性意义（P＞0．05）。结论中医证型分布与胃黏膜病理改变程度、H．pylori感染有一定的相关性。
Full Text Available An Edition of the Corpus areopagiticum slavicum In the fourteenth century, the monk Isaiah of the holy Mount Athos translated the writings of pseudo-Dionysius the Areopagite (c. end of the 5th century, core texts for Eastern and Western European theological and philosophical thought, from Greek into Church Slavonic. This first Slavic translation of Dionysius’ oeuvre (“De Coelesti Hierarchia,” “De Ecclesiastica Hierarchia,” “De Divinis Nominibus,” “De Mystica Theologia,” the epistles and scholia, which played a significant role in the development of Slavic culture, Orthodox Slavic socio-political theory and praxis, is still central to the study of Slavia Orthodoxa. A working group of German and Russian scholars has completed an edition of the translator’s Church Slavonic autograph with an en face reconstruction of the Greek text used by the translator and philological commentary. A Church Slavonic-Greek and Greek-Church Slavonic dictionary of this edition, currently in preparation, plans to make the terminology used in this influential translation accessible to interdisciplinary researchers. For the first time, the Church Slavonic lexica of this corpus, a substantial part of which was coined by the translator, will be registered in an index of words and forms.
Krakamp Bernd; Saers Thomas; Kirschberg Oliver; Brockmann Michael
Abstract Background We describe a rare case of diffuse macroscopic discoloration and chemical gastritis due to chronic bromazepam intake. The chemical composition of pharmaceuticals has to be considered at endoscopy and it is evident that some chemical substances damage the epithelial tissue and lead to clinical symptoms. Case Presentation Endoscopy was performed in an 82-year-old patient due to gastroesophageal reflux symptoms and epigastric pain. Gastroscopy showed a hiatal hernia and a sca...
Ramos Jiménez, F A; Arocena Cedrón, M G; Goikoetxea Artola, J M; Lázaro Aramburu, S; Múgica Barreiros, P
The authors present a case of phlegmonous gastritis in a 65 year old patient. The diagnosis was made in the operating room and the treatment was conservative; no gastric resection was done. This clinical entity is interesting because it is a least frequent pathology, the pathogenic bacteria which was the cause (Pseudomona aeruginosa) has at this time not been reported in the literature, including the favorable outcome of the patient without gastric resection. PMID:1633018
Soonami Choi; Yun Jeong Lim; Sue Kyung Park
AIM: To conduct a retrospective study to determine the risk factors for development of metaplastic gastritis in Korean population.METHODS: The database of 113449 subjects who underwent a gastroscopy for the purpose of a regular check-up at center for health promotion, Samsung medical center during 5 years was collected and retrospectively analyzed. Among them, 5847 subjects who had endoscopically diagnosed as a metaplastic gastritis or 10076 normal as well as answered to questionnaire were included for present study. The subjects were divided into 2 groups; Group Ⅰ, normal and Group Ⅱ, metaplastic gastritis. Age, gender, Helicobacter pylori(H pylori) seropositivity, body mass index (BMI),family history of cancer, smoking, alcohol consumption,total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating) were retrieved from questionnaire or electronic medical record and compared between group Ⅰ and group Ⅱ.RESULTS: The prevalence of group Ⅱ was 11%(13578/113449) increasing its prevalence with age(P= 0.000). But, there was no significant association between 2 groups in BMI, family history of cancer,alcohol consumption, total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating). Old age (P=0.000), male gender (P=0.000),H pylori seropositivity (P= 0.010) and current smoker (P= 0.000) were significantly more common in group Ⅱ at multiple logistic regression model.CONCLUSION: Our data suggested that old age, male gender,Hpyloriseropositivity and smoking were risk factors for metaplastic gastritis, precancerous lesion of gastric cancer.
Trowell, J E; Bell, G. D.
A 74 year old man presented with a one month history of epigastric discomfort, anorexia, weight loss, and postprandial vomiting. The diagnosis of ischaemia was made on endoscopic biopsies from the stomach and duodenum. He was too ill for major vascular surgery and died eight days after admission. Postmortem examination confirmed the diagnosis of splanchnic arterial insufficiency caused by atheroma and thrombosis. Ischaemic gastritis is rare but could easily be missed in unrepresentative biops...
Jensen, Kim Ebensgaard
into the possibility of inferring cultural models from naturally occurring verbal behavior as documented in language corpora. Even rarer are such corpus-based studies of the interaction between cultural models and constructions. Exploring the usability of corpus data and methodology in the observation...
Hardin, J. S.; Sarkis, G.; URC, P. .
We use the Enron email corpus to study relationships in a network by applying six different measures of centrality. Our results came out of an in-semester undergraduate research seminar. The Enron corpus is well suited to statistical analyses at all levels of undergraduate education. Through this article's focus on centrality, students can explore…
... 32 National Defense 3 2010-07-01 2010-07-01 true Habeas Corpus. 516.20 Section 516.20 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Reporting Legal Proceedings to HQDA § 516.20 Habeas Corpus. (a) General. A soldier...
Lynch, D A; Mapstone, N P; Clarke, A. M.; Sobala, G M; Jackson, P.; Morrison, L.; Dixon, M F; Quirke, P; Axon, A T
Helicobacter pylori causes chronic (type B) gastritis. The 'intestinal' form of gastric cancer arises against a background of chronic gastritis, and prospective epidemiological studies have shown that H pylori is a major risk factor for this. An increase in mucosal cell proliferation increases the likelihood of a neoplastic clone of epithelial cells emerging where there is chronic epithelial cell injury associated with H pylori gastritis. In vitro bromodeoxyuridine labelling of endoscopic ant...
Tomašević Ratko; Golubović Gradimir; Kiurski Miroslav; Stanković Dragana; Doder Radoje; Pavlović Aleksandar
Introduction. Helicobacter pylori (H. pylori) infection is known to be the must common cause of chronic gastritis having some endoscopic and pathologic characteristies as determinated by the Sydney System for Gastritis Classification. The aim of our case report was to point out the relationship between an endoscopic finding of nodular antritis and the presence of H. pylori infection and active chronic gastritis. Case report. Our patient underwent upper gastrointestinal endoscopy for dyspeptic...
Gonzalo Carrasco; Corvalan, Alejandro H.
Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the role of HP in the multistep cascade of GC. We attempt to define the role of the Operative Link for Gastritis Assessment (OLGA) staging system in assessing the risk of GC. The epi...
Martin, Heather R.; Shakya, Krishna P.; MUTHUPALANI, SURESHKUMAR; Ge, Zhongming; Klei, Thomas R.; Whary, Mark T.; James G Fox
In select Helicobacter pylori-infected populations with low gastric cancer, nematode coinfections are common and both helicobacter gastritis and filariasis are modeled in gerbils. We evaluated gastritis, worm counts, tissue cytokine gene expression levels and Th1/Th2-associated antibody responses in H. pylori and Brugia pahangi mono- and coinfected gerbils. H. pylori-associated gastritis indices were significantly lower 21 weeks post-infection in coinfected gerbils (p ≤ 0.05) and were inverse...
Phull, P S; Price, A. B.; Stephens, J; Rathbone, B J; Jacyna, M R
AIM: To compare the histological characteristics of Helicobacter pylori positive chronic gastritis in patients with and without associated duodenitis. METHODS: Gastric mucosal biopsy specimens were obtained from patients undergoing endoscopy for dyspepsia. Severity of gastritis and density of H pylori infection were graded according to the Sydney system. RESULTS: Of the 69 patients studied, 15 had normal histology, 22 had chronic gastritis only (77.3% H pylori positive), 21 had duodenitis (90...
Haot, J; Hamichi, L; Wallez, L; Mainguet, Paul
Lymphocytic gastritis is a histopathological entity characterised by the accumulation of small lymphocytes in the surface and foveolar epithelium. In order to investigate the correlation between endoscopy and histology in this condition, 192 observations selected on the basis of a presumed diagnosis of erosive or varioliform gastritis were reviewed. Ninety two instances corresponded to lymphocytic gastritis, while 100 did not show any particular microscopic feature and were labelled non-speci...
Gastritis is a common condition, with a variety of causes, that is diagnosed most often by barium upper gastrointestinal tract series or endoscopy. The authors report a case in which gastritis without active bleeding was apparent in scintiscans obtained during the evaluation of GI bleeding using /sup 99m/Tc-labeled red blood cells (TcRBC). The scintigraphic findings that suggest gastritis are described
Suskind, David; Wahbeh, Ghassan; Murray, Karen; Christie, Dennis; Kapur, Raj P
Collagenous gastritis is a rare gastrointestinal disorder characterized in pediatrics by abdominal pain and anemia. The literature divides collagenous gastritis into distinct pediatric-onset and adult-onset phenotypes. As opposed to pediatric form, the adult form is associated with collagenous colitis and presents clinically with voluminous non-bloody diarrhea. There are over 25 case reports of collagenous gastritis of which 10 are pediatric cases. We present two cases of pediatric onset coll...
Sutton, P.; Danon, S; Walker, M.; Thompson, L.; Wilson, J.; Kosaka, T; Lee, A.
BACKGROUND AND AIMS—Helicobacter pylori is a major cause of peptic ulcers and gastric cancer. Vaccine development is progressing but there is concern that immunisation may exacerbate Helicobacter induced gastritis: prophylactic immunisation followed by challenge with H felis or H pylori can induce a more severe gastritis in mice than seen with infection alone. The aim of this study was to investigate the relationship between immunity to Helicobacter infection and post-immunisation gastritis. ...
AIM: To classify the histological severity of Helicobacter pylori (H. pylori) infection-associated gastritis by confocal laser endomicroscopy (CLE). METHODS: Patients with upper gastrointestinal symptoms or individuals who were screened for gastric cancer were enrolled in this study. Histological severity of H. pylori infection-associated gastritis was graded according to the established CLE criteria. Diagnostic value of CLE for histo-logical gastritis was investigated and compared with that of white light ...
Full Text Available This article presents the building and putting online OF the oral corpus ESLO. Our purpose is to show that it is important not only to collect and make available language data and metadata but also to make explicit the whole chain of treatments. In the first part, we will present the project and the corpus, then we will specify the legal and methodological problems which determined all corpus treatments, in particular the anonymisation procedures which are required to freely make available this kind of resource. In the second part, we present different annotations made on the raw data with some examples of their use. We will explain the followed methodology which is always guided by the nature of the data and by the final objective: build a large sociolinguistic variationist oral corpus of French. Finally, we will discuss the issues of putting the corpus online.
Muazzam Ahmed Siddiqui
Full Text Available A corpus is a collection of documents. It is a valuable resource in linguistics research to perform statistical analysis and testing hypothesis for different linguistic rules. An annotated corpus consists of documents or entities annotated with some task related labels such as part of speech tags, sentiment etc One such task is plagiarism detection that seeks to identify if a given document is plagiarized or not. This paper describes our efforts to build a plagiarism detection corpus for Arabic. The corpus consists of about 350 plagiarized – source document pairs and more than 250 documents where no plagiarism was found. The plagiarized documents consists of students submitted assignments. For each of the plagiarized documents, the source document was located from the Web and downloaded for further investigation. We report corpus statistics including number of documents, number of sentences and number of tokens for each of the plagiarized and source categories.
Full Text Available Abstract Definition of the disease Malignant atrophic papulosis (MAP, described independently by Köhlmeier and Degos et al., is a rare, chronic, thrombo-obliterative vasculopathy characterized by papular skin lesions with central porcelain-white atrophy and surrounding teleangiectatic rim. Epidemiology Less than 200 cases have been described in the literature. The first manifestation of MAP usually occurs between the 20th and 50th year of life. Clinical description The cutaneous clinical picture is almost pathognomonic. The histology is not consistent but in most cases it shows a wedge-shaped connective tissue necrosis in the deep corium due to a thrombotic occlusion of the small arteries. In the systemic variant, manifestations mostly occur at the intestine and central nervous system. Etiology The etiopathogenesis of the disease remains unknown, a genetic predisposition may occur. Vasculitis, coagulopathy or primary dysfunction of the endothelial cells have been implicated. Diagnostic methods Diagnosis is only based on the characteristic skin lesions. Differrential diagnosis It depends on the clinical presentation of MAP, but systemic lupus erythematosus and other connective tissue diseases need to be considered. Management No effective treatment exists for the systemic manifestations, while compounds that facilitate blood perfusion have achieved a partial regression of the skin lesions in single cases. Prognosis An apparently idiopathic, monosymptomatic, cutaneous, benign variant and a progressive, visceral one with approx. 50% lethality within 2–3 years have been reported. Systemic manifestations can develop years after the occurrence of skin lesions leading to bowel perforation and peritonitis, thrombosis of the cerebral arteries or massive intracerebral hemorrhage, meningitis, encephalitis, radiculopathy, myelitis.
Wagner, S.; Gladziwa, U; Haruma, K; Varrentrapp, M; Gebel, M
Helicobacter pylori status, gastric histology, and 24 hour acidity were studied in 35 gastritis patients, 21 duodenal ulcer patients, and 14 subjects with normal gastric mucosa. H pylori was identified in 21 of 35 patients with chronic active gastritis and in 19 of 21 duodenal ulcer patients, but in none of those with normal gastric mucosa. Mean scores of activity of gastritis were similar in H pylori positive gastritis and duodenal ulcer patients, but were significantly lower in H pylori neg...
Greenwood, Deanne L. V.; Crock, Patricia; Braye, Stephen; Davidson, Patricia; Sentry, John W.
Autoimmune gastritis is characterised by lymphocytic infiltration of the gastric submucosa, with loss of parietal and chief cells and achlorhydria. Often, gastritis is expressed clinically as cobalamin deficiency with megaloblastic anaemia, which is generally described as a disease of the elderly. H
Blood serum in stomach cancer and chronic gastritis has been compared. A sharp decrease in pepsinogen 1 level both in cancer and gastritis patients was found as compared with healthy subjects. Pepsinogen 1 level in poorly-differentiated tumor (37.4 ng/ml) was lower than in well-differentiated one (58.2 ng/ml)