High-performance integrated virtual environment (HIVE): a robust infrastructure for next-generation sequence data analysis.

Science.gov (United States)

Simonyan, Vahan; Chumakov, Konstantin; Dingerdissen, Hayley; Faison, William; Goldweber, Scott; Golikov, Anton; Gulzar, Naila; Karagiannis, Konstantinos; Vinh Nguyen Lam, Phuc; Maudru, Thomas; Muravitskaja, Olesja; Osipova, Ekaterina; Pan, Yang; Pschenichnov, Alexey; Rostovtsev, Alexandre; Santana-Quintero, Luis; Smith, Krista; Thompson, Elaine E; Tkachenko, Valery; Torcivia-Rodriguez, John; Voskanian, Alin; Wan, Quan; Wang, Jing; Wu, Tsung-Jung; Wilson, Carolyn; Mazumder, Raja

2016-01-01

The High-performance Integrated Virtual Environment (HIVE) is a distributed storage and compute environment designed primarily to handle next-generation sequencing (NGS) data. This multicomponent cloud infrastructure provides secure web access for authorized users to deposit, retrieve, annotate and compute on NGS data, and to analyse the outcomes using web interface visual environments appropriately built in collaboration with research and regulatory scientists and other end users. Unlike many massively parallel computing environments, HIVE uses a cloud control server which virtualizes services, not processes. It is both very robust and flexible due to the abstraction layer introduced between computational requests and operating system processes. The novel paradigm of moving computations to the data, instead of moving data to computational nodes, has proven to be significantly less taxing for both hardware and network infrastructure.The honeycomb data model developed for HIVE integrates metadata into an object-oriented model. Its distinction from other object-oriented databases is in the additional implementation of a unified application program interface to search, view and manipulate data of all types. This model simplifies the introduction of new data types, thereby minimizing the need for database restructuring and streamlining the development of new integrated information systems. The honeycomb model employs a highly secure hierarchical access control and permission system, allowing determination of data access privileges in a finely granular manner without flooding the security subsystem with a multiplicity of rules. HIVE infrastructure will allow engineers and scientists to perform NGS analysis in a manner that is both efficient and secure. HIVE is actively supported in public and private domains, and project collaborations are welcomed. Database URL: https://hive.biochemistry.gwu.edu. © The Author(s) 2016. Published by Oxford University Press.

R and D areas for next generation desalination and water purification technologies

International Nuclear Information System (INIS)

Raha, A.; Rao, I.S.; Srivastava, V.K.; Tewari, P.K.

2007-01-01

By 2020, desalination and water purification technologies are expected to contribute significantly to ensure a safe, sustainable, affordable and adequate water supply. The cost of producing water from the current generation desalination technologies has declined over time at a rate of only approximately 4% per year. So we need to accelerate our research and development (R and D) activities with a near and long term objective for evolution of current generation desalination technology and to create revolutionary next generation advanced desalination and water purification technologies which will offer a promise of step reduction in cost of producing water. There are five broad technological areas-thermal technologies, membrane technologies, alternate technologies, concentrate management technologies, reuse and recycle technologies that encompass the spectrum of desalination technology. In this paper high priority research areas in all the above technologies areas are discussed to make decision about research direction that will help to mitigate our nation's future water supply challenges. (author)

The Evolving Wide Area Network Infrastructure in the LHC era

CERN Multimedia

CERN. Geneva

2004-01-01

The global network is more than ever taking its role as the great "enabler" for many branches of science and research. Foremost amongst such science drivers is of course the LHC/LCG programme, although there are several other sectors with growing demands of the network. Common to all of these is the realisation that a straightforward over provisioned best efforts wide area IP service is probably not enough for the future. This talk will summarise the needs of several science sectors, and the advances being made to exploit the current best efforts infrastructure. It will then describe current projects aimed as provisioning "better than best efforts" services (such bandwidth on demand), the global optical R&D testbeds and the strategy of the research network providers to move towards hybrid multi-service networks for the next generation of the global wide area production network.

The Next-Generation U.S. Retail Electricity Market with Customers and Prosumers—A Bibliographical Survey

Directory of Open Access Journals (Sweden)

Tao Chen

2017-12-01

Full Text Available Due to the rapidly-changing technologies in the power industry, many new references addressing the frameworks and business models of the next-generation retail electricity market are entering the research community. In particular, considering new customers with considerable demand response awareness and so-called prosumers with localized power generation based on distributed energy resources (DERs, the next-generation retail electricity market infrastructure will be a level playing field for local energy transactions, strategic pricing scheme design, new business model design and building an innovative energy ecosystem. Consequently, there is an urgent need to keep track of international experiences and activities taking place in the field of the market mechanism design problem at the distribution level. This paper provides a comprehensive survey of recent technology developments and aims to inspire awareness of the further deregulation of the electricity market, especially in areas close to customers. We mainly bring attention to the more than 90 articles published during the past five years. The collected literature has been divided into different sections to discuss different aspects of the next-generation retail electricity market under the deregulated power industry.

A new vision of the post-NIST civil infrastructure program: the challenges of next-generation construction materials and processes

Science.gov (United States)

Wu, H. Felix; Wan, Yan

2014-03-01

, security, and safety of elements of critical infrastructure for the Nation's already deteriorating civil infrastructure. It is envisioned that the Nation should look far beyond: not only should we efficiently and effectively address current problems of the aging infrastructure, but we must also further develop next-generation construction materials and processes for new construction. To accomplish this ambitious goal, we must include process efficiency that will help select the most reliable and cost-effective materials in construction processes; performance and cost will be the prime consideration for selections construction materials based on life-cycle cost and materials performance; energy efficiency will drive reduced energy consumption from current levels by 50 % per unit of output; and environmental responsiveness will achieve net-zero waste from construction materials and its constituents. Should it be successfully implemented, we will transform the current 21st century infrastructure systems to enable the vital functioning of society and improve competitiveness of the economy to ensure that our quality of life remains high.

Building the Next Generation of Digital Government Infrastructures

NARCIS (Netherlands)

Janssen, M.F.W.H.A.; Chun, S.A.; Gil-Garcia, J.R.

2009-01-01

Digital Government Infrastructures provide generic functionalities that are used by large numbers of users. Typically, they have no central authority, are governed by networks and contain both emerging and purposefully designed parts. Their use varies over time, and a large number of individuals use

Building next-generation converged networks theory and practice

CERN Document Server

Pathan, Al-Sakib Khan

2013-01-01

Supplying a comprehensive introduction to next-generation networks, Building Next-Generation Converged Networks: Theory and Practice strikes a balance between how and why things work and how to make them work. It compiles recent advancements along with basic issues from the wide range of fields related to next generation networks. Containing the contributions of 56 industry experts and researchers from 16 different countries, the book presents relevant theoretical frameworks and the latest research. It investigates new technologies such as IPv6 over Low Power Wireless Personal Area Network (6L

Designing Next Generation Telecom Regulation

DEFF Research Database (Denmark)

Henten, Anders; Samarajiva, Rohan

– ICT convergence regulation and multisector utility regulation. Whatever structure of next generation telecom regulation is adopted, all countries will need to pay much greater attention to the need for increased coordination of policy directions and regulatory activities both across the industries......Continuously expanding applications of information and communication technologies (ICT) are transforming local, national, regional and international economies into network economies, the foundation for information societies. They are being built upon expanded and upgraded national telecom networks...... to creating an environment to foster a massive expansion in the coverage and capabilities of the information infrastructure networks, with national telecom regulators as the key implementers of the policies of reform. The first phase of reform has focused on industry specific telecom policy and regulation...

Next generation terminology infrastructure to support interprofessional care planning.

Science.gov (United States)

Collins, Sarah; Klinkenberg-Ramirez, Stephanie; Tsivkin, Kira; Mar, Perry L; Iskhakova, Dina; Nandigam, Hari; Samal, Lipika; Rocha, Roberto A

2017-11-01

Develop a prototype of an interprofessional terminology and information model infrastructure that can enable care planning applications to facilitate patient-centered care, learn care plan linkages and associations, provide decision support, and enable automated, prospective analytics. The study steps included a 3 step approach: (1) Process model and clinical scenario development, and (2) Requirements analysis, and (3) Development and validation of information and terminology models. Components of the terminology model include: Health Concerns, Goals, Decisions, Interventions, Assessments, and Evaluations. A terminology infrastructure should: (A) Include discrete care plan concepts; (B) Include sets of profession-specific concerns, decisions, and interventions; (C) Communicate rationales, anticipatory guidance, and guidelines that inform decisions among the care team; (D) Define semantic linkages across clinical events and professions; (E) Define sets of shared patient goals and sub-goals, including patient stated goals; (F) Capture evaluation toward achievement of goals. These requirements were mapped to AHRQ Care Coordination Measures Framework. This study used a constrained set of clinician-validated clinical scenarios. Terminology models for goals and decisions are unavailable in SNOMED CT, limiting the ability to evaluate these aspects of the proposed infrastructure. Defining and linking subsets of care planning concepts appears to be feasible, but also essential to model interprofessional care planning for common co-occurring conditions and chronic diseases. We recommend the creation of goal dynamics and decision concepts in SNOMED CT to further enable the necessary models. Systems with flexible terminology management infrastructure may enable intelligent decision support to identify conflicting and aligned concerns, goals, decisions, and interventions in shared care plans, ultimately decreasing documentation effort and cognitive burden for clinicians and

Facilitating major new generation in Alberta : an overview of the transmission infrastructure requirements

International Nuclear Information System (INIS)

2001-01-01

There has been a growing interest in Alberta over the past year about building new generation. The three main areas under consideration are Fort McMurray, Edmonton, and Southern Alberta. Significant additional generation in these areas would inevitably create demands on the transmission infrastructure, which are examined in this report. It is difficult to predict what generation will be built over the next ten years, especially when several projects have not made it past the conceptual stage yet. Despite this difficulty, it is estimated that 6,500 MW of new generation will be added by 2010, based on the projects already announced and others. At off-peak periods, there would be a surplus capacity of almost 4,000 MW. Substantial upgrading of the transmission system in Alberta will be required if new generation is added, considering that the main transmission grid operates close to its maximum safe transfer limits for some periods. Significant improvements will be required for the transfer of the surplus generation from Fort McMurray to the main load centres of Southern Alberta (2,00 MW by 2010) and the Edmonton- Calgary corridor would also require updates. The estimated cost of these updates is 1.5 billion dollars. A prerequisite for many investors in new generation projects in Alberta is greater access to markets outside the province, and primarily to the western United States. Several options were examined in this report, from additional capacity through British Columbia, to a new route to Washington and Oregon via Montana, and a new route to Nevada and California. Some questions arise, such as whether the transmission infrastructure be built first or vice versa? The cost estimate for the direct line to Arizona/California for the export of 2,000 MW is 1.2 billion dollars. Close cooperation is required between planners and generation developers. 2 tabs., 6 figs

Next-generation phylogenomics

Directory of Open Access Journals (Sweden)

Chan Cheong Xin

2013-01-01

Full Text Available Abstract Thanks to advances in next-generation technologies, genome sequences are now being generated at breadth (e.g. across environments and depth (thousands of closely related strains, individuals or samples unimaginable only a few years ago. Phylogenomics – the study of evolutionary relationships based on comparative analysis of genome-scale data – has so far been developed as industrial-scale molecular phylogenetics, proceeding in the two classical steps: multiple alignment of homologous sequences, followed by inference of a tree (or multiple trees. However, the algorithms typically employed for these steps scale poorly with number of sequences, such that for an increasing number of problems, high-quality phylogenomic analysis is (or soon will be computationally infeasible. Moreover, next-generation data are often incomplete and error-prone, and analysis may be further complicated by genome rearrangement, gene fusion and deletion, lateral genetic transfer, and transcript variation. Here we argue that next-generation data require next-generation phylogenomics, including so-called alignment-free approaches. Reviewers Reviewed by Mr Alexander Panchin (nominated by Dr Mikhail Gelfand, Dr Eugene Koonin and Prof Peter Gogarten. For the full reviews, please go to the Reviewers’ comments section.

Next generation CANDU plants

International Nuclear Information System (INIS)

Hedges, K.R.; Yu, S.K.W.

1998-01-01

Future CANDU designs will continue to meet the emerging design and performance requirements expected by the operating utilities. The next generation CANDU products will integrate new technologies into both the product features as well as into the engineering and construction work processes associated with delivering the products. The timely incorporation of advanced design features is the approach adopted for the development of the next generation of CANDU. AECL's current products consist of 700MW Class CANDU 6 and 900 MW Class CANDU 9. Evolutionary improvements are continuing with our CANDU products to enhance their adaptability to meet customers ever increasing need for higher output. Our key product drivers are for improved safety, environmental protection and improved cost effectiveness. Towards these goals we have made excellent progress in Research and Development and our investments are continuing in areas such as fuel channels and passive safety. Our long term focus is utilizing the fuel cycle flexibility of CANDU reactors as part of the long term energy mix

Universal Intelligent Small Cell (UnISCell for next generation cellular networks

Directory of Open Access Journals (Sweden)

Mohammad Patwary

2016-11-01

Full Text Available Exploring innovative cellular architectures to achieve enhanced system capacity and good coverage has become a critical issue towards realizing the next generation of wireless communications. In this context, this paper proposes a novel concept of Universal Intelligent Small Cell (UnISCell for enabling the densification of the next generation of cellular networks. The proposed novel concept envisions an integrated platform of providing a strong linkage between different stakeholders such as street lighting networks, landline telephone networks and future wireless networks, and is universal in nature being independent of the operating frequency bands and traffic types. The main motivating factors for the proposed small cell concept are the need of public infrastructure re-engineering, and the recent advances in several enabling technologies. First, we highlight the main concepts of the proposed UnISCell platform. Subsequently, we present two deployment scenarios for the proposed UnISCell concept considering infrastructure sharing and service sharing as important aspects. We then describe the key future technologies for enabling the proposed UnISCell concept and present a use case example with the help of numerical results. Finally, we conclude this article by providing some interesting future recommendations.

Next-generation Algorithms for Assessing Infrastructure Vulnerability and Optimizing System Resilience

Energy Technology Data Exchange (ETDEWEB)

Burchett, Deon L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Chen, Richard Li-Yang [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Phillips, Cynthia A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Richard, Jean-Philippe [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-05-01

This report summarizes the work performed under the project project Next-Generation Algo- rithms for Assessing Infrastructure Vulnerability and Optimizing System Resilience. The goal of the project was to improve mathematical programming-based optimization technology for in- frastructure protection. In general, the owner of a network wishes to design a network a network that can perform well when certain transportation channels are inhibited (e.g. destroyed) by an adversary. These are typically bi-level problems where the owner designs a system, an adversary optimally attacks it, and then the owner can recover by optimally using the remaining network. This project funded three years of Deon Burchett's graduate research. Deon's graduate advisor, Professor Jean-Philippe Richard, and his Sandia advisors, Richard Chen and Cynthia Phillips, supported Deon on other funds or volunteer time. This report is, therefore. essentially a replication of the Ph.D. dissertation it funded [12] in a format required for project documentation. The thesis had some general polyhedral research. This is the study of the structure of the feasi- ble region of mathematical programs, such as integer programs. For example, an integer program optimizes a linear objective function subject to linear constraints, and (nonlinear) integrality con- straints on the variables. The feasible region without the integrality constraints is a convex polygon. Careful study of additional valid constraints can significantly improve computational performance. Here is the abstract from the dissertation: We perform a polyhedral study of a multi-commodity generalization of variable upper bound flow models. In particular, we establish some relations between facets of single- and multi- commodity models. We then introduce a new family of inequalities, which generalizes traditional flow cover inequalities to the multi-commodity context. We present encouraging numerical results. We also consider the directed

Designing Next Generation Massively Multithreaded Architectures for Irregular Applications

Energy Technology Data Exchange (ETDEWEB)

Tumeo, Antonino; Secchi, Simone; Villa, Oreste

2012-08-31

Irregular applications, such as data mining or graph-based computations, show unpredictable memory/network access patterns and control structures. Massively multi-threaded architectures with large node count, like the Cray XMT, have been shown to address their requirements better than commodity clusters. In this paper we present the approaches that we are currently pursuing to design future generations of these architectures. First, we introduce the Cray XMT and compare it to other multithreaded architectures. We then propose an evolution of the architecture, integrating multiple cores per node and next generation network interconnect. We advocate the use of hardware support for remote memory reference aggregation to optimize network utilization. For this evaluation we developed a highly parallel, custom simulation infrastructure for multi-threaded systems. Our simulator executes unmodified XMT binaries with very large datasets, capturing effects due to contention and hot-spotting, while predicting execution times with greater than 90% accuracy. We also discuss the FPGA prototyping approach that we are employing to study efficient support for irregular applications in next generation manycore processors.

HIGHWAY INFRASTRUCTURE FOCUS AREA NEXT-GENERATION INFRASTRUCTURE MATERIALS VOLUME I - TECHNICAL PROPOSAL & MANAGEMENTENHANCEMENT OF TRANSPORTATION INFRASTRUCTURE WITH IRON-BASED AMORPHOUS-METAL AND CERAMIC COATINGS

Energy Technology Data Exchange (ETDEWEB)

Farmer, J C

2007-12-04

The infrastructure for transportation in the United States allows for a high level of mobility and freight activity for the current population of 300 million residents, and several million business establishments. According to a Department of Transportation study, more than 230 million motor vehicles, ships, airplanes, and railroads cars were used on 6.4 million kilometers (4 million miles) of highways, railroads, airports, and waterways in 1998. Pipelines and storage tanks were considered to be part of this deteriorating infrastructure. The annual direct cost of corrosion in the infrastructure category was estimated to be approximately $22.6 billion in 1998. There were 583,000 bridges in the United States in 1998. Of this total, 200,000 bridges were steel, 235,000 were conventional reinforced concrete, 108,000 bridges were constructed using pre-stressed concrete, and the balance was made using other materials of construction. Approximately 15 percent of the bridges accounted for at this point in time were structurally deficient, primarily due to corrosion of steel and steel reinforcement. Iron-based amorphous metals, including SAM2X5 (Fe{sub 49.7}Cr{sub 17.7}Mn{sub 1.9}Mo{sub 7.4}W{sub 1.6}B{sub 15.2}C{sub 3.8}Si{sub 2.4}) and SAM1651 (Fe{sub 48}Mo{sub 14}Cr{sub 15}Y{sub 2}C{sub 15}B{sub 6}) have been developed, and have very good corrosion resistance. These materials have been prepared as a melt-spun ribbons, as well as gas atomized powders and thermal-spray coatings. During electrochemical testing in several environments, including seawater at 90 C, the passive film stabilities of these materials were found to be comparable to that of more expensive high-performance alloys, based on electrochemical measurements of the passive film breakdown potential and general corrosion rates. These materials also performed very well in standard salt fog tests. Chromium (Cr), molybdenum (Mo) and tungsten (W) provided corrosion resistance, and boron (B) enabled glass formation

Next generation initiation techniques

Science.gov (United States)

Warner, Tom; Derber, John; Zupanski, Milija; Cohn, Steve; Verlinde, Hans

1993-01-01

Four-dimensional data assimilation strategies can generally be classified as either current or next generation, depending upon whether they are used operationally or not. Current-generation data-assimilation techniques are those that are presently used routinely in operational-forecasting or research applications. They can be classified into the following categories: intermittent assimilation, Newtonian relaxation, and physical initialization. It should be noted that these techniques are the subject of continued research, and their improvement will parallel the development of next generation techniques described by the other speakers. Next generation assimilation techniques are those that are under development but are not yet used operationally. Most of these procedures are derived from control theory or variational methods and primarily represent continuous assimilation approaches, in which the data and model dynamics are 'fitted' to each other in an optimal way. Another 'next generation' category is the initialization of convective-scale models. Intermittent assimilation systems use an objective analysis to combine all observations within a time window that is centered on the analysis time. Continuous first-generation assimilation systems are usually based on the Newtonian-relaxation or 'nudging' techniques. Physical initialization procedures generally involve the use of standard or nonstandard data to force some physical process in the model during an assimilation period. Under the topic of next-generation assimilation techniques, variational approaches are currently being actively developed. Variational approaches seek to minimize a cost or penalty function which measures a model's fit to observations, background fields and other imposed constraints. Alternatively, the Kalman filter technique, which is also under investigation as a data assimilation procedure for numerical weather prediction, can yield acceptable initial conditions for mesoscale models. The

Wireless and wireline service convergence in next generation optical access networks - the FP7 WISCON project

DEFF Research Database (Denmark)

Vegas Olmos, Juan José; Pang, Xiaodan; Lebedev, Alexander

2014-01-01

The next generation of information technology demands both high capacity and mobility for applications such as high speed wireless access capable of supporting broadband services. The transport of wireless and wireline signals is converging into a common telecommunication infrastructure....... In this paper, we will present the Marie Curie Framework Program 7 project “Wireless and wireline service convergence in next generation optical access networks” (WISCON), which focuses on the conception and study of novel architectures for wavelength-division-multiplexing (WDM) optical multi-modulation format...

Next generation sensors and systems

CERN Document Server

2016-01-01

Written by experts in their area of research, this book has outlined the current status of the fundamentals and analytical concepts, modelling and design issues, technical details and practical applications of different types of sensors and discussed about the trends of next generation of sensors and systems happening in the area of Sensing technology. This book will be useful as a reference book for engineers and scientist especially the post-graduate students find will this book as reference book for their research on wearable sensors, devices and technologies.  .

Next generation environment for collaborative research

International Nuclear Information System (INIS)

Collados, D.; Denis, G.; Galvez, P.; Newman, H.

2001-01-01

Collaborative environments supporting point to point and multipoint video-conferencing, document and application sharing across both local and wide area networks, video on demand (broadcast and playback) and interactive text facilities will be a crucial element for the development of the next generation of HEP experiments by geographically dispersed collaborations. The 'Virtual Room Video conferencing System' (VRVS) has been developed since 1995, in order to provide a low cost, bandwidth-efficient, extensible means for video conferencing and remote collaboration over networks within the High Energy and Nuclear Physics communities. The VRVS provides worldwide videoconferencing service and collaborative environment to the research and education communities. VRVS uses the Internet2 and ESnet high-performance networks infrastructure to deploy its Web-based system, which now includes more than 5790 registered hosts running VRVS software in more than 50 different countries. VRVS hosts an average of 100-multipoint videoconference and collaborative sessions worldwide every month. There are around 35 reflectors that manage the traffic flow, at HENP labs and universities in the US and Europe. So far, there are 7 Virtual Rooms for World Wide Conferences (involving more than one continent), and 4 Virtual Rooms each for intra-continental conferences in the US, Europe and Asia. VRVS continues to expand and implement new digital video technologies, including H.323 ITU standard integration, MPEG-2 videoconferencing integration, shared environments, and Quality of Service

Visions, Scenarios and Action Plans Towards Next Generation Tanzania Power System

Directory of Open Access Journals (Sweden)

Alex Kyaruzi

2012-10-01

Full Text Available This paper presents strategic visions, scenarios and action plans for enhancing Tanzania Power Systems towards next generation Smart Power Grid. It first introduces the present Tanzanian power grid and the challenges ahead in terms of generation capacity, financial aspect, technical and non-technical losses, revenue loss, high tariff, aging infrastructure, environmental impact and the interconnection with the neighboring countries. Then, the current initiatives undertaken by the Tanzania government in response to the present challenges and the expected roles of smart grid in overcoming these challenges in the future with respect to the scenarios presented are discussed. The developed scenarios along with visions and recommended action plans towards the future Tanzanian power system can be exploited at all governmental levels to achieve public policy goals and help develop business opportunities by motivating domestic and international investments in modernizing the nation’s electric power infrastructure. In return, it should help build the green energy economy.

Infrastructure Area Simplification Plan

CERN Document Server

Field, L.

2011-01-01

The infrastructure area simplification plan was presented at the 3rd EMI All Hands Meeting in Padova. This plan only affects the information and accounting systems as the other areas are new in EMI and hence do not require simplification.

Risk analysis of underground infrastructures in urban areas

International Nuclear Information System (INIS)

Cagno, Enrico; De Ambroggi, Massimiliano; Grande, Ottavio; Trucco, Paolo

2011-01-01

The paper presents an integrated approach for vulnerability and resilience analysis for underground infrastructures, i.e. a societal risk analysis of the failures of underground services for an urban area. The approach is based on the detailed study of (1) domino-effects for the components of a single infrastructure and for a given set of infrastructures interoperated and/or belonging to the same area; (2) risk and vulnerability analysis of a given area; (3) identification of a set of intervention guidelines, in order to improve the overall system resilience. The use of an integrated (interoperability and area) approach, breaking down the analysis area extent into sub-areas and assessing the dependencies among sub-areas both in terms of interoperability and damage propagation of critical infrastructures, demonstrates a useful advantage in terms of resilience analysis, more consistent with the 'zoned' nature of failures of the underground infrastructures. An applied case, describing the interoperability and damage propagation analysis with the evaluation of time-dependency for the infrastructures and targets and of different kinds of interventions of the underground infrastructures of a town, is presented for this purpose.

Investment dimensions in a universal service perspective: Next generation networks, alternative funding mechanisms and public-private partnerships

DEFF Research Database (Denmark)

Falch, Morten; Henten, Anders

2008-01-01

This paper seeks to examine the investment dimensions of next generation networks from a universal service perspective in a European context. The question is how new network infrastructures for providing access for everyone to communication, information and entertainment services in the present...

Next generation light water reactors

International Nuclear Information System (INIS)

Omoto, Akira

1992-01-01

In the countries where the new order of nuclear reactors has ceased, the development of the light water reactors of new type has been discussed, aiming at the revival of nuclear power. Also in Japan, since it is expected that light water reactors continue to be the main power reactor for long period, the technology of light water reactors of next generation has been discussed. For the development of nuclear power, extremely long lead time is required. The light water reactors of next generation now in consideration will continue to be operated till the middle of the next century, therefore, they must take in advance sufficiently the needs of the age. The improvement of the way men and the facilities should be, the simple design, the flexibility to the trend of fuel cycle and so on are required for the light water reactors of next generation. The trend of the development of next generation light water reactors is discussed. The construction of an ABWR was started in September, 1991, as No. 6 plant in Kashiwazaki Kariwa Power Station. (K.I.)

The Next Generation Information Infrastructure for International Trade

DEFF Research Database (Denmark)

Henningsson, Stefan; Gal, Uri; Bjørn-Andersen, Niels

2011-01-01

that are in control of their business. Trusted traders are entitled to trade facilitations, faster border crossing, and fewer physical inspections. To enable the use of trusted traders, changes are required to the information infrastructure (II) of international trade. This article complements existing works on e......-Government interoperability by a theoretically driven approach with theoretical development of the II concept and how II can be modified as additional focus. Following the principles of IS design research, this paper presents a design proposition for the II of international trade. Using theories of II development and change......Regulators and actors in international trade are facing a difficult challenge of increasing control and security while at the same time lowering the administrative burden for traders. As a tentative response, the European Commission has introduced the concept of “trusted traders”: certified traders...

A Rural Next Generation Network (R-NGN and Its Testbed

Directory of Open Access Journals (Sweden)

Armein Z. R. Langi

2007-05-01

Full Text Available Rural Next Generation Networks (R-NGN technology allows Internet protocol (IP based systems to be used in rural areas. This paper reports a testbed of R-NGN that uses low cost Ethernet radio links, combined with media gateways and a softswitch. The network consists of point-to-point IP Ethernet 2.4 GHz wireless link, IP switches and gateways in each community, standard copper wires and telephone sets for users. It uses low power consumption, and suitable for low density users. This combination allows low cost systems as well as multiservices (voice, data, and multimedia for rural communications. An infrastructure has been deployed in two communities in Cipicung Girang, a village 10 km outside Bandung city, Indonesia. Two towers link the communities with a network of Institut Teknologi Bandung (ITB campus. In addition, local wirelines connect community houses to the network. Currently there are four houses connected to each community node (for a total of eight house, upon which we can perform various tests and measurements.

A Rural Next Generation Network (R-NGN and Its Testbed

Directory of Open Access Journals (Sweden)

Armein Z. R. Langi

2013-09-01

Full Text Available Rural Next Generation Networks (R-NGN technology allows Internet protocol (IP based systems to be used in rural areas. This paper reports a testbed of R-NGN that uses low cost Ethernet radio links, combined with media gateways and a softswitch. The network consists of point-to-point IP Ethernet 2.4 GHz wireless link, IP switches and gateways in each community, standard copper wires and telephone sets for users. It uses low power consumption, and suitable for low density users. This combination allows low cost systems as well as multiservices (voice, data, and multimedia for rural communications. An infrastructure has been deployed in two communities in Cipicung Girang, a village 10 km outside Bandung city, Indonesia. Two towers link the communities with a network of Institut Teknologi Bandung (ITB campus. In addition, local wirelines connect community houses to the network. Currently there are four houses connected to each community node (for a total of eight house, upon which we can perform various tests and measurements.

Convergence of wireless, wireline, and photonics next generation networks

CERN Document Server

Iniewski, Krzysztof

2010-01-01

Filled with illustrations and practical examples from industry, this book provides a brief but comprehensive introduction to the next-generation wireless networks that will soon replace more traditional wired technologies. Written by a mixture of top industrial experts and key academic professors, it is the only book available that covers both wireless networks (such as wireless local area and personal area networks) and optical networks (such as long-haul and metropolitan networks) in one volume. It gives engineers and engineering students the necessary knowledge to meet challenges of next-ge

Building safeguards infrastructure

International Nuclear Information System (INIS)

Stevens, Rebecca S.; McClelland-Kerr, John

2009-01-01

Much has been written in recent years about the nuclear renaissance - the rebirth of nuclear power as a clean and safe source of electricity around the world. Those who question the nuclear renaissance often cite the risk of proliferation, accidents or an attack on a facility as concerns, all of which merit serious consideration. The integration of these three areas - sometimes referred to as 3S, for safety, security and safeguards - is essential to supporting the growth of nuclear power, and the infrastructure that supports them should be strengthened. The focus of this paper will be on the role safeguards plays in the 3S concept and how to support the development of the infrastructure necessary to support safeguards. The objective of this paper has been to provide a working definition of safeguards infrastructure, and to discuss xamples of how building safeguards infrastructure is presented in several models. The guidelines outlined in the milestones document provide a clear path for establishing both the safeguards and the related infrastructures needed to support the development of nuclear power. The model employed by the INSEP program of engaging with partner states on safeguards-related topics that are of current interest to the level of nuclear development in that state provides another way of approaching the concept of building safeguards infrastructure. The Next Generation Safeguards Initiative is yet another approach that underscored five principal areas for growth, and the United States commitment to working with partners to promote this growth both at home and abroad.

AugerNext: innovative research studies for the next generation ground-based ultra-high energy cosmic ray experiment

Directory of Open Access Journals (Sweden)

Haungs Andreas

2013-06-01

Full Text Available The findings so far of the Pierre Auger Observatory and also of the Telescope Array define the requirements for a possible next generation experiment: it needs to be considerably increased in size, it needs a better sensitivity to composition, and it should cover the full sky. AugerNext aims to perform innovative research studies in order to prepare a proposal fulfilling these demands. Such R&D studies are primarily focused in the following areas iconsolidation of the detection of cosmic rays using MHz radio antennas; iiproof-of-principle of cosmic-ray microwave detection; iiitest of the large-scale application of a new generation photo-sensors; ivgeneralization of data communication techniques; vdevelopment of new ways of muon detection with surface arrays. These AugerNext studies on new innovative detection methods for a next generation cosmic-ray experiment are performed at the Pierre Auger Observatory. The AugerNext consortium consists presently of fourteen partner institutions from nine European countries supported by a network of European funding agencies and it is a principal element of the ASPERA/ApPEC strategic roadmaps.

Novel nanostructures for next generation dye-sensitized solar cells

KAUST Repository

Té treault, Nicolas; Grä tzel, Michael

2012-01-01

Herein, we review our latest advancements in nanostructured photoanodes for next generation photovoltaics in general and dye-sensitized solar cells in particular. Bottom-up self-assembly techniques are developed to fabricate large-area 3D

Generation Next

Science.gov (United States)

Hawkins, B. Denise

2010-01-01

There is a shortage of accounting professors with Ph.D.s who can prepare the next generation. To help reverse the faculty deficit, the American Institute of Certified Public Accountants (CPAs) has created the new Accounting Doctoral Scholars program by pooling more than $17 million and soliciting commitments from more than 70 of the nation's…

Next Generation HeliMag UXO Mapping Technology

Science.gov (United States)

2010-01-01

Ancillary instrumentation records aircraft height above ground and attitude. A fluxgate magnetometer is used to allow for aeromagnetic compensation of... Magnetometer System WWII World War II WAA wide area assessment ACKNOWLEDGEMENTS This Next Generation HeliMag Unexploded Ordnance (UXO) Mapping...for deployment of seven total-field magnetometers on a Kevlar reinforced boom mounted on a Bell 206L helicopter. The objectives of this

THE TRAINING OF NEXT GENERATION DATA SCIENTISTS IN BIOMEDICINE.

Science.gov (United States)

Garmire, Lana X; Gliske, Stephen; Nguyen, Quynh C; Chen, Jonathan H; Nemati, Shamim; VAN Horn, John D; Moore, Jason H; Shreffler, Carol; Dunn, Michelle

2017-01-01

With the booming of new technologies, biomedical science has transformed into digitalized, data intensive science. Massive amount of data need to be analyzed and interpreted, demand a complete pipeline to train next generation data scientists. To meet this need, the transinstitutional Big Data to Knowledge (BD2K) Initiative has been implemented since 2014, complementing other NIH institutional efforts. In this report, we give an overview the BD2K K01 mentored scientist career awards, which have demonstrated early success. We address the specific trainings needed in representative data science areas, in order to make the next generation of data scientists in biomedicine.

DIII-D Integrated plasma control solutions for ITER and next-generation tokamaks

International Nuclear Information System (INIS)

Humphreys, D.A.; Ferron, J.R.; Hyatt, A.W.; La Haye, R.J.; Leuer, J.A.; Penaflor, B.G.; Walker, M.L.; Welander, A.S.; In, Y.

2008-01-01

Plasma control design approaches and solutions developed at DIII-D to address its control-intensive advanced tokamak (AT) mission are applicable to many problems facing ITER and other next-generation devices. A systematic approach to algorithm design, termed 'integrated plasma control,' enables new tokamak controllers to be applied operationally with minimal machine time required for tuning. Such high confidence plasma control algorithms are designed using relatively simple ('control-level') models validated against experimental response data and are verified in simulation prior to operational use. A key element of DIII-D integrated plasma control, also required in the ITER baseline control approach, is the ability to verify both controller performance and implementation by running simulations that connect directly to the actual plasma control system (PCS) that is used to operate the tokamak itself. The DIII-D PCS comprises a powerful and flexible C-based realtime code and programming infrastructure, as well as an arbitrarily scalable hardware and realtime network architecture. This software infrastructure provides a general platform for implementation and verification of realtime algorithms with arbitrary complexity, limited only by speed of execution requirements. We present a complete suite of tools (known collectively as TokSys) supporting the integrated plasma control design process, along with recent examples of control algorithms designed for the DIII-D PCS. The use of validated physics-based models and a systematic model-based design and verification process enables these control solutions to be directly applied to ITER and other next-generation tokamaks

Next Generation Microshutter Arrays Project

Data.gov (United States)

National Aeronautics and Space Administration — We propose to develop the next generation MicroShutter Array (MSA) as a multi-object field selector for missions anticipated in the next two decades. For many...

Project control - the next generation

International Nuclear Information System (INIS)

Iorii, V.F.; McKinnon, B.L.

1993-01-01

The Yucca Mountain Site Characterization Project (YMP) is the U.S. Department of Energy's (DOE) second largest Major System Acquisition Project. We have developed an integrated planning and control system (called PACS) that we believe represents the 'Next Generation' in project control. PACS integrates technical scope, cost, and schedule information for over 50 participating organizations and produces performances measurement reports for science and engineering managers at all levels. Our 'Next Generation' project control too, PACS, has been found to be in compliance with the new DOE Project Control System Guidelines. Additionally, the nuclear utility oversight group of the Edison Electric Institute has suggested PACS be used as a model for other civilian radioactive waste management projects. A 'Next Generation' project control tool will be necessary to do science in the 21st century

Digital Earth reloaded - Beyond the next generation

Science.gov (United States)

Ehlers, M.; Woodgate, P.; Annoni, A.; Schade, S.

2014-02-01

Digital replicas (or 'mirror worlds') of complex entities and systems are now routine in many fields such as aerospace engineering; archaeology; medicine; or even fashion design. The Digital Earth (DE) concept as a digital replica of the entire planet occurs in Al Gore's 1992 book Earth in the Balance and was popularized in his speech at the California Science Center in January 1998. It played a pivotal role in stimulating the development of a first generation of virtual globes, typified by Google Earth that achieved many elements of this vision. Almost 15 years after Al Gore's speech, the concept of DE needs to be re-evaluated in the light of the many scientific and technical developments in the fields of information technology, data infrastructures, citizen?s participation, and earth observation that have taken place since. This paper intends to look beyond the next generation predominantly based on the developments of fields outside the spatial sciences, where concepts, software, and hardware with strong relationships to DE are being developed without referring to this term. It also presents a number of guiding criteria for future DE developments.

NextGen Future Safety Assessment Game

Science.gov (United States)

Ancel, Ersin; Gheorghe, Adrian; Jones, Sharon Monica

2011-01-01

The successful implementation of the next generation infrastructure systems requires solid understanding of their technical, social, political and economic aspects along with their interactions. The lack of historical data that relate to the long-term planning of complex systems introduces unique challenges for decision makers and involved stakeholders which in turn result in unsustainable systems. Also, the need to understand the infrastructure at the societal level and capture the interaction between multiple stakeholders becomes important. This paper proposes a methodology in order to develop a holistic approach aiming to provide an alternative subject-matter expert (SME) elicitation and data collection method for future sociotechnical systems. The methodology is adapted to Next Generation Air Transportation System (NextGen) decision making environment in order to demonstrate the benefits of this holistic approach.

Next Generation Safeguards Initiative: Human Capital Development

International Nuclear Information System (INIS)

Scholz, M.; Irola, G.; Glynn, K.

2015-01-01

Since 2008, the Human Capital Development (HCD) subprogramme of the U.S. National Nuclear Security Administration's (NNSA) Next Generation Safeguards Initiative (NGSI) has supported the recruitment, education, training, and retention of the next generation of international safeguards professionals to meet the needs of both the International Atomic Energy Agency (IAEA) and the United States. Specifically, HCD's efforts respond to data indicating that 82% of safeguards experts at U.S. Laboratories will have left the workforce within 15 years. This paper provides an update on the status of the subprogramme since its last presentation at the IAEA Safeguards Symposium in 2010. It highlights strengthened, integrated efforts in the areas of graduate and post-doctoral fellowships, young and midcareer professional support, short safeguards courses, and university engagement. It also discusses lessons learned from the U.S. experience in safeguards education and training as well as the importance of long-range strategies to develop a cohesive, effective, and efficient human capital development approach. (author)

Next-Generation Tools For Next-Generation Surveys

Science.gov (United States)

Murray, S. G.

2017-04-01

The next generation of large-scale galaxy surveys, across the electromagnetic spectrum, loom on the horizon as explosively game-changing datasets, in terms of our understanding of cosmology and structure formation. We are on the brink of a torrent of data that is set to both confirm and constrain current theories to an unprecedented level, and potentially overturn many of our conceptions. One of the great challenges of this forthcoming deluge is to extract maximal scientific content from the vast array of raw data. This challenge requires not only well-understood and robust physical models, but a commensurate network of software implementations with which to efficiently apply them. The halo model, a semi-analytic treatment of cosmological spatial statistics down to nonlinear scales, provides an excellent mathematical framework for exploring the nature of dark matter. This thesis presents a next-generation toolkit based on the halo model formalism, intended to fulfil the requirements of next-generation surveys. Our toolkit comprises three tools: (i) hmf, a comprehensive and flexible calculator for halo mass functions (HMFs) within extended Press-Schechter theory, (ii) the MRP distribution for extremely efficient analytic characterisation of HMFs, and (iii) halomod, an extension of hmf which provides support for the full range of halo model components. In addition to the development and technical presentation of these tools, we apply each to the task of physical modelling. With hmf, we determine the precision of our knowledge of the HMF, due to uncertainty in our knowledge of the cosmological parameters, over the past decade of cosmic microwave background (CMB) experiments. We place rule-of-thumb uncertainties on the predicted HMF for the Planck cosmology, and find that current limits on the precision are driven by modeling uncertainties rather than those from cosmological parameters. With the MRP, we create and test a method for robustly fitting the HMF to observed

Dynalight Next Generation

DEFF Research Database (Denmark)

Jørgensen, Bo Nørregaard; Ottosen, Carl-Otto; Dam-Hansen, Carsten

2016-01-01

The project aims to develop the next generation of energy cost-efficient artificial lighting control that enables greenhouse growers to adapt their use of artificial lighting dynamically to fluctuations in the price of electricity. This is a necessity as fluctuations in the price of electricity c...

NASA's Next Generation Space Geodesy Program

Science.gov (United States)

Merkowitz, S. M.; Desai, S. D.; Gross, R. S.; Hillard, L. M.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Murphy, D.; Noll, C. E.;

Access regulation in the next generation access network environment: A comparative study of Hong Kong and Singapore from the transaction cost economics perspectives

OpenAIRE

Ho, Au Man

2012-01-01

Hong Kong and Singapore have adopted two different models in the regulation of the next generation access (NGA) networks. In Hong Kong, the government has decided that access regulation will not be applied to fibre-based access networks and its strategy will be to rely on facilities-based competition to promote investment in the NGA networks. Singapore, on the other hand, has promoted access/services-based competition over a next generation broadband infrastructure subsidised by public fundin...

Generation 'Next' and nuclear power

International Nuclear Information System (INIS)

Sergeev, A.A.

2001-01-01

My generation was labeled by Russian mass media as generation 'Next.' My technical education is above average. My current position is as a mechanical engineer in the leading research and development institute for Russian nuclear engineering for peaceful applications. It is noteworthy to point out that many of our developments were really first-of-a-kind in the history of engineering. However, it is difficult to grasp the importance of these accomplishments, especially since the progress of nuclear technologies is at a standstill. Can generation 'Next' be independent in their attitude towards nuclear power or shall we rely on the opinions of elder colleagues in our industry? (authors)

The Next Great Generation?

Science.gov (United States)

Brownstein, Andrew

2000-01-01

Discusses ideas from a new book, "Millennials Rising: The Next Great Generation," (by Neil Howe and William Strauss) suggesting that youth culture is on the cusp of a radical shift with the generation beginning with this year's college freshmen who are typically team oriented, optimistic, and poised for greatness on a global scale. Includes a…

Development of technology for next generation reactor - Development of next generation reactor in Korea -

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Kyun; Chang, Moon Heuy; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of); and others

1993-09-01

The project, development of next generation reactor, aims overall related technology development and obtainment of related license in 2001. The development direction is to determine the reactor type and to build up the design concept in 1994. For development trend analysis of foreign next generation reactor, level-1 PSA, fuel cycle analysis and computer code development are performed on System 80+ and AP 600. Especially for design characteristics analysis and volume upgrade of AP 600, nuclear fuel and reactor core design analysis, coolant circuit design analysis, mechanical structure design analysis and safety analysis etc. are performed. (Author).

Connected vehicle insights : fourth generation wireless - vehicle and highway gateways to the cloud.

Science.gov (United States)

2011-12-01

This paper examines next generation wide-area cellular such as fourth generation (4G) will be able to support vehicular applications, and how transportation infrastructure may mesh with wireless networks. : This report is part of the Connected Vehicl...

Tailoring next-generation biofuels and their combustion in next-generation engines

Energy Technology Data Exchange (ETDEWEB)

Gladden, John Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Wu, Weihua [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Taatjes, Craig A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Scheer, Adam Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Turner, Kevin M. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yu, Eizadora T. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); O' Bryan, Greg [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Powell, Amy Jo [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gao, Connie W. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

2013-11-01

Increasing energy costs, the dependence on foreign oil supplies, and environmental concerns have emphasized the need to produce sustainable renewable fuels and chemicals. The strategy for producing next-generation biofuels must include efficient processes for biomass conversion to liquid fuels and the fuels must be compatible with current and future engines. Unfortunately, biofuel development generally takes place without any consideration of combustion characteristics, and combustion scientists typically measure biofuels properties without any feedback to the production design. We seek to optimize the fuel/engine system by bringing combustion performance, specifically for advanced next-generation engines, into the development of novel biosynthetic fuel pathways. Here we report an innovative coupling of combustion chemistry, from fundamentals to engine measurements, to the optimization of fuel production using metabolic engineering. We have established the necessary connections among the fundamental chemistry, engine science, and synthetic biology for fuel production, building a powerful framework for co-development of engines and biofuels.

Proceedings of the international workshop on next-generation linear colliders

International Nuclear Information System (INIS)

Riordan, M.

1988-12-01

This report contains papers on the next-generation of linear colliders. The particular areas of discussion are: parameters; beam dynamics and wakefields; damping rings and sources; rf power sources; accelerator structures; instrumentation; final focus; and review of beam-beam interaction

Proceedings of the international workshop on next-generation linear colliders

Energy Technology Data Exchange (ETDEWEB)

Riordan, M. (ed.)

1988-12-01

This report contains papers on the next-generation of linear colliders. The particular areas of discussion are: parameters; beam dynamics and wakefields; damping rings and sources; rf power sources; accelerator structures; instrumentation; final focus; and review of beam-beam interaction.

Cluster cosmology with next-generation surveys.

Science.gov (United States)

Ascaso, B.

2017-03-01

The advent of next-generation surveys will provide a large number of cluster detections that will serve the basis for constraining cos mological parameters using cluster counts. The main two observational ingredients needed are the cluster selection function and the calibration of the mass-observable relation. In this talk, we present the methodology designed to obtain robust predictions of both ingredients based on realistic cosmological simulations mimicking the following next-generation surveys: J-PAS, LSST and Euclid. We display recent results on the selection functions for these mentioned surveys together with others coming from other next-generation surveys such as eROSITA, ACTpol and SPTpol. We notice that the optical and IR surveys will reach the lowest masses between 0.3next-generation surveys and introduce very preliminary results.

Digital Earth reloaded – Beyond the next generation

International Nuclear Information System (INIS)

Ehlers, M; Woodgate, P; Annoni, A; Schade, S

2014-01-01

Digital replicas (or 'mirror worlds') of complex entities and systems are now routine in many fields such as aerospace engineering; archaeology; medicine; or even fashion design. The Digital Earth (DE) concept as a digital replica of the entire planet occurs in Al Gore's 1992 book Earth in the Balance and was popularized in his speech at the California Science Center in January 1998. It played a pivotal role in stimulating the development of a first generation of virtual globes, typified by Google Earth that achieved many elements of this vision. Almost 15 years after Al Gore's speech, the concept of DE needs to be re-evaluated in the light of the many scientific and technical developments in the fields of information technology, data infrastructures, citizen?s participation, and earth observation that have taken place since. This paper intends to look beyond the next generation predominantly based on the developments of fields outside the spatial sciences, where concepts, software, and hardware with strong relationships to DE are being developed without referring to this term. It also presents a number of guiding criteria for future DE developments

Investment opportunities in infrastructure regardless of financial crisis

OpenAIRE

ILIE Georgeta

2009-01-01

During these times of dramatic change and financial market disorder, the challenge of infrastructure development is being drawn more into the highlight. Infrastructure will be rising in importance over the next years. The availability and quality of infrastructure directly affect where business operations are located and expanded. In this context, roads and power generation are the most urgent infrastructure needs. The paper reveals a few economic characteristics of current stage of infrastru...

Next Generation Inverter

Energy Technology Data Exchange (ETDEWEB)

Zhao, Zilai [General Motors LLC, Detroit, MI (United States); Gough, Charles [General Motors LLC, Detroit, MI (United States)

2016-04-22

The goal of this Cooperative Agreement was the development of a Next Generation Inverter for General Motors’ electrified vehicles, including battery electric vehicles, range extended electric vehicles, plug-in hybrid electric vehicles and hybrid electric vehicles. The inverter is a critical electronics component that converts battery power (DC) to and from the electric power for the motor (AC).

StarTrax --- The Next Generation User Interface

Science.gov (United States)

Richmond, Alan; White, Nick

StarTrax is a software package to be distributed to end users for installation on their local computing infrastructure. It will provide access to many services of the HEASARC, i.e. bulletins, catalogs, proposal and analysis tools, initially for the ROSAT MIPS (Mission Information and Planning System), later for the Next Generation Browse. A user activating the GUI will reach all HEASARC capabilities through a uniform view of the system, independent of the local computing environment and of the networking method of accessing StarTrax. Use it if you prefer the point-and-click metaphor of modern GUI technology, to the classical command-line interfaces (CLI). Notable strengths include: easy to use; excellent portability; very robust server support; feedback button on every dialog; painstakingly crafted User Guide. It is designed to support a large number of input devices including terminals, workstations and personal computers. XVT's Portability Toolkit is used to build the GUI in C/C++ to run on: OSF/Motif (UNIX or VMS), OPEN LOOK (UNIX), or Macintosh, or MS-Windows (DOS), or character systems.

Technical presentation: Next Generation Oscilloscopes

CERN Multimedia

PH Department

2011-01-01

  Rohde & Schwarz "Next Generation Oscilloscopes" - Introduction and Presentation Agenda: Wednesday 23 March  -  09:30 to 11:30 (open end) Bldg. 13-2-005 Language: English 09.30 Presentation "Next Generation Oscilloscopes" from Rohde & Schwarz RTO / RTM in theory and practice Gerard Walker 10.15 Technical design details from R&D Dr. Markus Freidhof 10.45 Scope and Probe Roadmap (confidential) Guido Schulze 11.00 Open Discussion Feedback, first impression, wishes, needs and requirements from CERN All 11.30 Expert Talks, Hands on All Mr. Dr. Markus Freidhof, Head of R&D Oscilloscopes, Rohde & Schwarz, Germany; Mr. Guido Schulze, ...

Next generation toroidal devices

International Nuclear Information System (INIS)

Yoshikawa, Shoichi

1998-10-01

A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one's view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

Next generation toroidal devices

Energy Technology Data Exchange (ETDEWEB)

Yoshikawa, Shoichi [Princeton Plasma Physics Lab., Princeton Univ., NJ (United States)

1998-10-01

A general survey of the possible approach for the next generation toroidal devices was made. Either surprisingly or obviously (depending on one`s view), the technical constraints along with the scientific considerations lead to a fairly limited set of systems for the most favorable approach for the next generation devices. Specifically if the magnetic field strength of 5 T or above is to be created by superconducting coils, it imposes minimum in the aspect ratio for the tokamak which is slightly higher than contemplated now for ITER design. The similar technical constraints make the minimum linear size of a stellarator large. Scientifically, it is indicated that a tokamak of 1.5 times in the linear dimension should be able to produce economically, especially if a hybrid reactor is allowed. For the next stellarator, it is strongly suggested that some kind of helical axis is necessary both for the (almost) absolute confinement of high energy particles and high stability and equilibrium beta limits. The author still favors a heliac most. Although it may not have been clearly stated in the main text, the stability afforded by the shearless layer may be exploited fully in a stellarator. (author)

Next Generation Safeguards Initiative: 2010 and Beyond

International Nuclear Information System (INIS)

Whitney, J.M.; LaMontagne, S.; Sunshine, A.; Lockwood, D.; Peranteau, D.; Dupuy, G.

2010-01-01

Strengthening the international safeguards system is a key element of the U.S. non-proliferation policy agenda as evidenced by President Obama's call for more 'resources and authority to strengthen international inspections' in his April 2009 Prague speech. Through programs such as the recently-launched Next Generation Safeguards Initiative (NGSI) and the long standing U.S. Program of Technical Assistance to IAEA Safeguards, the United States is working to implement this vision. The U.S. Department of Energy's National Nuclear Security Administration launched NGSI in 2008 to develop the policies, concepts, technologies, expertise, and international safeguards infrastructure necessary to strengthen and sustain the international safeguards system as it evolves to meet new challenges. Following a successful 2009, NGSI has made significant progress toward these goals in 2010. NGSI has recently completed a number of policy studies on advanced safeguards concepts and sponsored several workshops, including a second international meeting on Harmonization of International Safeguards Infrastructure Development in Vienna. The program is also continuing multi-year projects to investigate advanced non-destructive assay techniques, enhance recruitment and training efforts, and strengthen international cooperation on safeguards. In December 2010, NGSI will host the Third Annual International Meeting on International Safeguards in Washington, DC, which will draw together key stakeholders from government, the nuclear industry, and the IAEA to further develop and promote a common understanding of Safeguards by Design principles and goals, and to identify opportunities for practical application of the concept. This paper presents a review of NGSI program activities in 2010 and previews plans for upcoming activities. (author)

Safety Arguments for Next Generation, Location Aware Computing

Science.gov (United States)

Johnson, C. W.; Holloway, C. M.

2010-01-01

Concerns over accuracy, availability, integrity, and continuity have limited the integration of Global Positioning System (GPS) and Global Navigation Satellite System (GLONASS) for safety-critical applications. More recent augmentation systems, such as the European Geostationary Navigation Overlay Service (EGNOS) and the North American Wide Area Augmentation System (WAAS) have begun to address these concerns. Augmentation architectures build on the existing GPS/GLONASS infrastructures to support location based services in Safety of Life (SoL) applications. Much of the technical development has been directed by air traffic management requirements, in anticipation of the more extensive support to be offered by GPS III and Galileo. WAAS has already been approved to provide vertical guidance for aviation applications. During the next twelve months, the full certification of EGNOS for SoL applications is expected. This paper discusses similarities and differences between the safety assessment techniques used in Europe and North America.

A Next Generation BioPhotonics Workstation

DEFF Research Database (Denmark)

Glückstad, Jesper; Palima, Darwin; Tauro, Sandeep

2011-01-01

We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials.......We are developing a Next Generation BioPhotonics Workstation to be applied in research on regulated microbial cell growth including their underlying physiological mechanisms, in vivo characterization of cell constituents and manufacturing of nanostructures and meta-materials....

Next Generation Microchannel Heat Exchangers

CERN Document Server

Ohadi, Michael; Dessiatoun, Serguei; Cetegen, Edvin

2013-01-01

In Next Generation Microchannel Heat Exchangers, the authors’ focus on the new generation highly efficient heat exchangers and presentation of novel data and technical expertise not available in the open literature.  Next generation micro channels offer record high heat transfer coefficients with pressure drops much less than conventional micro channel heat exchangers. These inherent features promise fast penetration into many mew markets, including high heat flux cooling of electronics, waste heat recovery and energy efficiency enhancement applications, alternative energy systems, as well as applications in mass exchangers and chemical reactor systems. The combination of up to the minute research findings and technical know-how make this book very timely as the search for high performance heat and mass exchangers that can cut costs in materials consumption intensifies.

Policy Framework for the Next Generation Platform as a Service

DEFF Research Database (Denmark)

Kentis, Angelos Mimidis; Ollora Zaballa, Eder; Soler, José

2018-01-01

The Platform-as-a-Service (PaaS) model, allows service providers to build and deploy their services following streamlined work-flows. However, platforms deployed through the PaaS model can be very diverse in terms of technologies and involved subsystems (e.g. infrastructure, orchestration). Thus,......-wide and technology-agnostic policies to NGPaaS, by means of abstraction of the underlying platforms and the use of generic interfaces. The paper also presents a specific use case for the proposed framework, which targets network-oriented policies......., the means for deploying and managing a service can significantly vary depending on the deployed platform. To address this issue, this paper proposes a policy-based framework designed for the Next Generation Platform-as-a-Service (NGPaaS). This framework allows service providers to define platform...

Progress on next generation linear colliders

International Nuclear Information System (INIS)

Ruth, R.D.

1989-01-01

In this paper, I focus on reviewing the issues and progress on a next generation linear collider with the general parameters of energy, luminosity, length, power, technology. The energy range is dictated by physics with a mass reach well beyond LEP, although somewhat short of SSC. The luminosity is that required to obtain 10 3 /minus/ 10 4 units of R 0 per year. The length is consistent with a site on Stanford land with collisions occurring on the SLAC site. The power was determined by economic considerations. Finally, the technology was limited by the desire to have a next generation linear collider before the next century. 25 refs., 3 figs., 6 tabs

Next generation of accelerators

International Nuclear Information System (INIS)

Richter, B.

1979-01-01

Existing high-energy accelerators are reviewed, along with those under construction or being designed. Finally, some of the physics issues which go into setting machine parameters, and some of the features of the design of next generation electron and proton machines are discussed

Prospects for next-generation e+e- linear colliders

International Nuclear Information System (INIS)

Ruth, R.D.

1990-02-01

The purpose of this paper is to review progress in the US towards a next generation linear collider. During 1988, there were three workshops held on linear colliders: ''Physics of Linear Colliders,'' in Capri, Italy, June 14--18, 1988; Snowmass 88 (Linear Collider subsection) June 27--July 15, 1988; and SLAC International Workshop on Next Generation Linear Colliders, November 28--December 9, 1988. In this paper, I focus on reviewing the issues and progress on a next generation linear collider. The energy range is dictated by physics with a mass reach well beyond LEP, although somewhat short of SSC. The luminosity is that required to obtain 10 3 --10 4 units of R 0 per year. The length is consistent with a site on Stanford land with collision occurring on the SLAC site; the power was determined by economic considerations. Finally, the technology as limited by the desire to have a next generation linear collider by the next century. 37 refs., 3 figs., 6 tabs

Spotted hyaena space use in relation to human infrastructure inside a protected area.

Science.gov (United States)

Belton, Lydia E; Cameron, Elissa Z; Dalerum, Fredrik

2016-01-01

Increasing human population growth has led to elevated levels of human-carnivore conflict. However, some carnivore populations have adapted to urban environments and the resources they supply. Such associations may influence carnivore ecology, behaviour and life-history. Pockets of urbanisation sometimes occur within protected areas, so that anthropogenic influences on carnivore biology are not necessarily confined to unprotected areas. In this study we evaluated associations between human infrastructure and related activity and space use of spotted hyaenas within one of the largest protected areas in South Africa, the Kruger National Park. Home range size was smaller for the dominant female of a clan living in close proximity to humans than that of the dominant female of a clan without direct access to human infrastructure. The home range including human infrastructure was also used less evenly during the night, presumably when the animals were active. Within this home range, a village area was preferred during the night, when the least modified areas within the village were preferred and administration and highly modified areas were avoided. During the day, however, there were no preference or avoidance of the village area, but all habitats except unmodified habitats within the village area were avoided. We suggest that human infrastructure and associated activity influenced hyaena space use, primarily through alterations in the spatial distribution of food. However, these effects may have been indirectly caused by habitat modification that generated favourable hunting habitat rather than a direct effect caused by access to human food such as garbage. Because of the often pivotal effects of apex predators in terrestrial ecosystems, we encourage further work aimed to quantify how human presence influences large carnivores and associated ecosystem processes within protected areas.

Better-Than-Visual Technologies for Next Generation Air Transportation System Terminal Maneuvering Area Operations

Science.gov (United States)

Prinzel, Lawrence J., III; Bailey, Randall E.; Shelton, Kevin J.; Jones, Denise R.; Kramer, Lynda J.; Arthur, Jarvis J., III; Williams, Steve P.; Barmore, Bryan E.; Ellis, Kyle E.; Rehfeld, Sherri A.

2011-01-01

A consortium of industry, academia and government agencies are devising new concepts for future U.S. aviation operations under the Next Generation Air Transportation System (NextGen). Many key capabilities are being identified to enable NextGen, including the concept of Equivalent Visual Operations (EVO) replicating the capacity and safety of today's visual flight rules (VFR) in all-weather conditions. NASA is striving to develop the technologies and knowledge to enable EVO and to extend EVO towards a Better-Than-Visual (BTV) operational concept. The BTV operational concept uses an electronic means to provide sufficient visual references of the external world and other required flight references on flight deck displays that enable VFR-like operational tempos and maintain and improve the safety of VFR while using VFR-like procedures in all-weather conditions. NASA Langley Research Center (LaRC) research on technologies to enable the concept of BTV is described.

Next generation PanDA pilot for ATLAS and other experiments

International Nuclear Information System (INIS)

Nilsson, P; De, K; Megino, F Barreiro; Llamas, R Medrano; Bejar, J Caballero; Hover, J; Maeno, T; Wenaus, T; Love, P; Walker, R

2014-01-01

The Production and Distributed Analysis system (PanDA) has been in use in the ATLAS Experiment since 2005. It uses a sophisticated pilot system to execute submitted jobs on the worker nodes. While originally designed for ATLAS, the PanDA Pilot has recently been refactored to facilitate use outside of ATLAS. Experiments are now handled as plug-ins such that a new PanDA Pilot user only has to implement a set of prototyped methods in the plug-in classes, and provide a script that configures and runs the experiment-specific payload. We will give an overview of the Next Generation PanDA Pilot system and will present major features and recent improvements including live user payload debugging, data access via the Federated XRootD system, stage-out to alternative storage elements, support for the new ATLAS DDM system (Rucio), and an improved integration with glExec, as well as a description of the experiment-specific plug-in classes. The performance of the pilot system in processing LHC data on the OSG, LCG and Nordugrid infrastructures used by ATLAS will also be presented. We will describe plans for future development on the time scale of the next few years.

SCOS2: ESA's new generation of mission control systems

Science.gov (United States)

Kaufeler, J. F.; Head, N. C.

1993-01-01

The paper describes the next generation Spacecraft Control System infrastructure (SCOSII) which is being developed at the Operations Centre (ESOC) of the European Space Agency (ESA). The objectives of the new system and selected areas of the proposed hardware and software approach are described.

Career Advancement: Meeting the Challenges Confronting the Next Generation of Endocrinologists and Endocrine Researchers.

Science.gov (United States)

Santen, Richard J; Joham, Anju; Fishbein, Lauren; Vella, Kristen R; Ebeling, Peter R; Gibson-Helm, Melanie; Teede, Helena

2016-12-01

Challenges and opportunities face the next generation (Next-Gen) of endocrine researchers and clinicians, the lifeblood of the field of endocrinology for the future. A symposium jointly sponsored by The Endocrine Society and the Endocrine Society of Australia was convened to discuss approaches to addressing the present and future Next-Gen needs. Data collection by literature review, assessment of previously completed questionnaires, commissioning of a new questionnaire, and summarization of symposium discussions were studied. Next-Gen endocrine researchers face diminishing grant funding in inflation-adjusted terms. The average age of individuals being awarded their first independent investigator funding has increased to age 45 years. For clinicians, a workforce gap exists between endocrinologists needed and those currently trained. Clinicians in practice are increasingly becoming employees of integrated hospital systems, resulting in greater time spent on nonclinical issues. Workforce data and published reviews identify challenges specifically related to early career women in endocrinology. Strategies to Address Issues: Recommendations encompassed the areas of grant support for research, mentoring, education, templates for career development, specific programs for Next-Gen members by senior colleagues as outlined in the text, networking, team science, and life/work integration. Endocrine societies focusing on Next-Gen members provide a powerful mechanism to support these critical areas. A concerted effort to empower, train, and support the next generation of clinical endocrinologists and endocrine researchers is necessary to ensure the viability and vibrancy of our discipline and to optimize our contributions to improving health outcomes. Collaborative engagement of endocrine societies globally will be necessary to support our next generation moving forward.

Overview of NASA's Next Generation Air Transportation System (NextGen) Research

Science.gov (United States)

Swenson, Harry N.

2009-01-01

This slide presentation is an overview of the research for the Next Generation Air Transportation System (NextGen). Included is a review of the current air transportation system and the challenges of air transportation research. Also included is a review of the current research highlights and significant accomplishments.

Next Generation Social Networks

DEFF Research Database (Denmark)

Sørensen, Lene Tolstrup; Skouby, Knud Erik

2008-01-01

different online networks for communities of people who share interests or individuals who presents themselves through user produced content is what makes up the social networking of today. The purpose of this paper is to discuss perceived user requirements to the next generation social networks. The paper...

Optical Subsystems for Next Generation Access Networks

DEFF Research Database (Denmark)

Lazaro, J.A; Polo, V.; Schrenk, B.

2011-01-01

Recent optical technologies are providing higher flexibility to next generation access networks: on the one hand, providing progressive FTTx and specifically FTTH deployment, progressively shortening the copper access network; on the other hand, also opening fixed-mobile convergence solutions...... in next generation PON architectures. It is provided an overview of the optical subsystems developed for the implementation of the proposed NG-Access Networks....

Key thrusts in next generation CANDU. Annex 10

International Nuclear Information System (INIS)

Shalaby, B.A.; Torgerson, D.F.; Duffey, R.B.

2002-01-01

Current electricity markets and the competitiveness of other generation options such as CCGT have influenced the directions of future nuclear generation. The next generation CANDU has used its key characteristics as the basis to leap frog into a new design featuring improved economics, enhanced passive safety, enhanced operability and demonstrated fuel cycle flexibility. Many enabling technologies spinning of current CANDU design features are used in the next generation design. Some of these technologies have been developed in support of existing plants and near term designs while others will need to be developed and tested. This paper will discuss the key principles driving the next generation CANDU design and the fuel cycle flexibility of the CANDU system which provide synergism with the PWR fuel cycle. (author)

Next-generation sequencing for endocrine cancers: Recent advances and challenges.

Science.gov (United States)

Suresh, Padmanaban S; Venkatesh, Thejaswini; Tsutsumi, Rie; Shetty, Abhishek

2017-05-01

Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Microarray analyses have provided gene signatures from many cells, tissues, and organs that can differentiate healthy states from diseased ones, and even show patterns that correlate with stages of a disease. Microarray data can also elucidate the responses of endocrine tumors to therapeutic treatments. The rapid progress in next-generation sequencing methods has overcome many of the initial challenges of these technologies, and their advantages over microarray techniques have enabled them to emerge as valuable aids for clinical research applications (prognosis, identification of drug targets, etc.). A comprehensive review describing the recent advances in next-generation sequencing methods and their application in the evaluation of endocrine and endocrine-related cancers is lacking. The main purpose of this review is to illustrate the concepts that collectively constitute our current view of the possibilities offered by next-generation sequencing technological platforms, challenges to relevant applications, and perspectives on the future of clinical genetic testing of patients with endocrine tumors. We focus on recent discoveries in the use of next-generation sequencing methods for clinical diagnosis of endocrine tumors in patients and conclude with a discussion on persisting challenges and future objectives.

Next Generation Biopharmaceuticals: Product Development.

Science.gov (United States)

Mathaes, Roman; Mahler, Hanns-Christian

2018-04-11

Therapeutic proteins show a rapid market growth. The relatively young biotech industry already represents 20 % of the total global pharma market. The biotech industry environment has traditionally been fast-pasted and intellectually stimulated. Nowadays the top ten best selling drugs are dominated by monoclonal antibodies (mABs).Despite mABs being the biggest medical breakthrough in the last 25 years, technical innovation does not stand still.The goal remains to preserve the benefits of a conventional mAB (serum half-life and specificity) whilst further improving efficacy and safety and to open new and better avenues for treating patients, e.g., improving the potency of molecules, target binding, tissue penetration, tailored pharmacokinetics, and reduced adverse effects or immunogenicity.The next generation of biopharmaceuticals can pose specific chemistry, manufacturing, and control (CMC) challenges. In contrast to conventional proteins, next-generation biopharmaceuticals often require lyophilization of the final drug product to ensure storage stability over shelf-life time. In addition, next-generation biopharmaceuticals require analytical methods that cover different ways of possible degradation patterns and pathways, and product development is a long way from being straight forward. The element of "prior knowledge" does not exist equally for most novel formats compared to antibodies, and thus the assessment of critical quality attributes (CQAs) and the definition of CQA assessment criteria and specifications is difficult, especially in early-stage development.

Recent progress in nanostructured next-generation field emission devices

International Nuclear Information System (INIS)

Mittal, Gaurav; Lahiri, Indranil

2014-01-01

Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40–50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices. (topical review)

Recent progress in nanostructured next-generation field emission devices

Science.gov (United States)

Mittal, Gaurav; Lahiri, Indranil

2014-08-01

Field emission has been known to mankind for more than a century, and extensive research in this field for the last 40-50 years has led to development of exciting applications such as electron sources, miniature x-ray devices, display materials, etc. In the last decade, large-area field emitters were projected as an important material to revolutionize healthcare and medical devices, and space research. With the advent of nanotechnology and advancements related to carbon nanotubes, field emitters are demonstrating highly enhanced performance and novel applications. Next-generation emitters need ultra-high emission current density, high brightness, excellent stability and reproducible performance. Novel design considerations and application of new materials can lead to achievement of these capabilities. This article presents an overview of recent developments in this field and their effects on improved performance of field emitters. These advancements are demonstrated to hold great potential for application in next-generation field emission devices.

NASA's Next Generation Space Geodesy Network

Science.gov (United States)

Desai, S. D.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry, J. F.; Merkowitz, S. M.; Murphy, D.; Noll, C. E.;

Next Generation Summer School

Science.gov (United States)

Eugenia, Marcu

2013-04-01

On 21.06.2010 the "Next Generation" Summer School has opened the doors for its first students. They were introduced in the astronomy world by astronomical observations, astronomy and radio-astronomy lectures, laboratory projects meant to initiate them into modern radio astronomy and radio communications. The didactic programme was structure as fallowing: 1) Astronomical elements from the visible spectrum (lectures + practical projects) 2) Radio astronomy elements (lectures + practical projects) 3) Radio communication base (didactic- recreative games) The students and professors accommodation was at the Agroturistic Pension "Popasul Iancului" situated at 800m from the Marisel Observatory. First day (summer solstice day) began with a practical activity: determination of the meridian by measurements of the shadow (the direction of one vertical alignment, when it has the smallest length). The experiment is very instructive and interesting because combines notions of physics, spatial geometry and basic astronomy elements. Next day the activities took place in four stages: the students processed the experimental data obtained on first day (on sheets of millimetre paper they represented the length of the shadow alignments according the time), each team realised its own sun quadrant, point were given considering the design and functionality of these quadrant, the four teams had to mimic important constellations on carton boards with phosphorescent sticky stars and the students, accompanied by the professors took a hiking trip to the surroundings, marking the interest point coordinates, using a GPS to establish the geographical coronations and at the end of the day the students realised a small map of central Marisel area based on the GPS data. On the third day, the students were introduced to basic notions of radio astronomy, the principal categories of artificial Earth satellites: low orbit satellites (LEO), Medium orbit satellites (MEO) and geostationary satellites (GEO

Next Generation Solar Collectors for CSP

Energy Technology Data Exchange (ETDEWEB)

Molnar, Attila [3M Company, St. Paul, MN (United States); Charles, Ruth [3M Company, St. Paul, MN (United States)

2014-07-31

The intent of “Next Generation Solar Collectors for CSP” program was to develop key technology elements for collectors in Phase 1 (Budget Period 1), design these elements in Phase 2 (Budget Period 2) and to deploy and test the final collector in Phase 3 (Budget Period 3). 3M and DOE mutually agreed to terminate the program at the end of Budget Period 1, primarily due to timeline issues. However, significant advancements were achieved in developing a next generation reflective material and panel that has the potential to significantly improve the efficiency of CSP systems.

Towards a Unified Global ICT Infrastructure

DEFF Research Database (Denmark)

Madsen, Ole Brun

2006-01-01

A successful evolution towards a unified global WAN platform allowing for the coexistence and interoperability of all kind of services requires careful planning of the next generation global cooperative wired and wireless information infrastructure. The absence of commonly agreed upon and adopted...... to be solved can be found in the interrelation between communication, connectivity and convergence. This paper will focus on steps to be taken in planning the physical infrastructure as a prerequisite for a successful evolution....

Next generation PWR

International Nuclear Information System (INIS)

Tanaka, Toshihiko; Fukuda, Toshihiko; Usui, Shuji

2001-01-01

Development of LWR for power generation in Japan has been intended to upgrade its reliability, safety, operability, maintenance and economy as well as to increase its capacity in order, since nuclear power generation for commercial use was begun on 1970, to steadily increase its generation power. And, in Japan, ABWR (advanced BWR) of the most promising LWR in the world, was already used actually and APWR (advanced PWR) with the largest output in the world is also at a step of its actual use. And, development of the APWR in Japan was begun on 1980s, and is at a step of plan on construction of its first machine at early of this century. However, by large change of social affairs, economy of nuclear power generation is extremely required, to be positioned at an APWR improved development reactor promoted by collaboration of five PWR generation companies and the Mitsubishi Electric Co., Ltd. Therefore, on its development, investigation on effect of change in social affairs on nuclear power stations was at first carried out, to establish a design requirement for the next generation PWR. Here were described on outline, reactor core design, safety concept, and safety evaluation of APWR+ and development of an innovative PWR. (G.K.)

Next generation framework for aquatic modeling of the Earth System

Science.gov (United States)

Fekete, B. M.; Wollheim, W. M.; Wisser, D.; Vörösmarty, C. J.

2009-03-01

Earth System model development is becoming an increasingly complex task. As scientists attempt to represent the physical and bio-geochemical processes and various feedback mechanisms in unprecedented detail, the models themselves are becoming increasingly complex. At the same time, the complexity of the surrounding IT infrastructure is growing as well. Earth System models must manage a vast amount of data in heterogeneous computing environments. Numerous development efforts are on the way to ease that burden and offer model development platforms that reduce IT challenges and allow scientists to focus on their science. While these new modeling frameworks (e.g. FMS, ESMF, CCA, OpenMI) do provide solutions to many IT challenges (performing input/output, managing space and time, establishing model coupling, etc.), they are still considerably complex and often have steep learning curves. The Next generation Framework for Aquatic Modeling of the Earth System (NextFrAMES, a revised version of FrAMES) have numerous similarities to those developed by other teams, but represents a novel model development paradigm. NextFrAMES is built around a modeling XML that lets modelers to express the overall model structure and provides an API for dynamically linked plugins to represent the processes. The model XML is executed by the NextFrAMES run-time engine that parses the model definition, loads the module plugins, performs the model I/O and executes the model calculations. NextFrAMES has a minimalistic view representing spatial domains and treats every domain (regardless of its layout such as grid, network tree, individual points, polygons, etc.) as vector of objects. NextFrAMES performs computations on multiple domains and interactions between different spatial domains are carried out through couplers. NextFrAMES allows processes to operate at different frequencies by providing rudimentary aggregation and disaggregation facilities. NextFrAMES was designed primarily for

Identification and Characterization of Key Human Performance Issues and Research in the Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Lee, Paul U.; Sheridan, Tom; Poage, james L.; Martin, Lynne Hazel; Jobe, Kimberly K.

2010-01-01

This report identifies key human-performance-related issues associated with Next Generation Air Transportation System (NextGen) research in the NASA NextGen-Airspace Project. Four Research Focus Areas (RFAs) in the NextGen-Airspace Project - namely Separation Assurance (SA), Airspace Super Density Operations (ASDO), Traffic Flow Management (TFM), and Dynamic Airspace Configuration (DAC) - were examined closely. In the course of the research, it was determined that the identified human performance issues needed to be analyzed in the context of NextGen operations rather than through basic human factors research. The main gaps in human factors research in NextGen were found in the need for accurate identification of key human-systems related issues within the context of specific NextGen concepts and better design of the operational requirements for those concepts. By focusing on human-system related issues for individual concepts, key human performance issues for the four RFAs were identified and described in this report. In addition, mixed equipage airspace with components of two RFAs were characterized to illustrate potential human performance issues that arise from the integration of multiple concepts.

Technology Trends in Cloud Infrastructure

CERN Multimedia

CERN. Geneva

2018-01-01

Cloud computing is growing at an exponential pace with an increasing number of workloads being hosted in mega-scale public clouds such as Microsoft Azure. Designing and operating such large infrastructures requires not only a significant capital spend for provisioning datacenters, servers, networking and operating systems, but also R&D investments to capitalize on disruptive technology trends and emerging workloads such as AI/ML. This talk will cover the various infrastructure innovations being implemented in large scale public clouds and opportunities/challenges ahead to deliver the next generation of scale computing. About the speaker Kushagra Vaid is the general manager and distinguished engineer for Hardware Infrastructure in the Microsoft Azure division. He is accountable for the architecture and design of compute and storage platforms, which are the foundation for Microsoft’s global cloud-scale services. He and his team have successfully delivered four generations of hyperscale cloud hardwar...

NNSA Program Develops the Next Generation of Nuclear Security Experts

Energy Technology Data Exchange (ETDEWEB)

Brim, Cornelia P.; Disney, Maren V.

2015-09-02

NNSA is fostering the next generation of nuclear security experts is through its successful NNSA Graduate Fellowship Program (NGFP). NGFP offers its Fellows an exceptional career development opportunity through hands-on experience supporting NNSA mission areas across policy and technology disciplines. The one-year assignments give tomorrow’s leaders in global nuclear security and nonproliferation unparalleled exposure through assignments to Program Offices across NNSA.

The NASA Next Generation Stirling Technology Program Overview

Science.gov (United States)

Schreiber, J. G.; Shaltens, R. K.; Wong, W. A.

2005-12-01

NASAs Science Mission Directorate is developing the next generation Stirling technology for future Radioisotope Power Systems (RPS) for surface and deep space missions. The next generation Stirling convertor is one of two advanced power conversion technologies currently being developed for future NASA missions, and is capable of operating for both planetary atmospheres and deep space environments. The Stirling convertor (free-piston engine integrated with a linear alternator) produces about 90 We(ac) and has a specific power of about 90 We/kg. Operating conditions of Thot at 850 degree C and Trej at 90 degree C results in the Stirling convertor estimated efficiency of about 40 per cent. Using the next generation Stirling convertor in future RPS, the "system" specific power is estimated at 8 We/kg. The design lifetime is three years on the surface of Mars and fourteen years in deep space missions. Electrical power of about 160 We (BOM) is produced by two (2) free-piston Stirling convertors heated by two (2) General Purpose Heat Source (GPHS) modules. This development is being performed by Sunpower, Athens, OH with Pratt & Whitney, Rocketdyne, Canoga Park, CA under contract to Glenn Research Center (GRC), Cleveland, Ohio. GRC is guiding the independent testing and technology development for the next generation Stirling generator.

Rhamnolipids--next generation surfactants?

Science.gov (United States)

Müller, Markus Michael; Kügler, Johannes H; Henkel, Marius; Gerlitzki, Melanie; Hörmann, Barbara; Pöhnlein, Martin; Syldatk, Christoph; Hausmann, Rudolf

2012-12-31

The demand for bio-based processes and materials in the petrochemical industry has significantly increased during the last decade because of the expected running out of petroleum. This trend can be ascribed to three main causes: (1) the increased use of renewable resources for chemical synthesis of already established product classes, (2) the replacement of chemical synthesis of already established product classes by new biotechnological processes based on renewable resources, and (3) the biotechnological production of new molecules with new features or better performances than already established comparable chemically synthesized products. All three approaches are currently being pursued for surfactant production. Biosurfactants are a very promising and interesting substance class because they are based on renewable resources, sustainable, and biologically degradable. Alkyl polyglycosides are chemically synthesized biosurfactants established on the surfactant market. The first microbiological biosurfactants on the market were sophorolipids. Of all currently known biosurfactants, rhamnolipids have the highest potential for becoming the next generation of biosurfactants introduced on the market. Although the metabolic pathways and genetic regulation of biosynthesis are known qualitatively, the quantitative understanding relevant for bioreactor cultivation is still missing. Additionally, high product titers have been exclusively described with vegetable oil as sole carbon source in combination with Pseudomonas aeruginosa strains. Competitive productivity is still out of reach for heterologous hosts or non-pathogenic natural producer strains. Thus, on the one hand there is a need to gain a deeper understanding of the regulation of rhamnolipid production on process and cellular level during bioreactor cultivations. On the other hand, there is a need for metabolizable renewable substrates, which do not compete with food and feed. A sustainable bioeconomy approach should

Physical Configuration of the Next Generation Home Network

Science.gov (United States)

Terada, Shohei; Kakishima, Yu; Hanawa, Dai; Oguchi, Kimio

The number of broadband users is rapidly increasing worldwide. Japan already has over 10 million FTTH users. Another trend is the rapid digitalization of home electrical equipment e. g. digital cameras and hard disc recorders. These trends will encourage the emergence of the next generation home network. In this paper, we introduce the next generation home network image and describe the five domains into which home devices can be classified. We then clarify the optimum medium with which to configure the network given the requirements imposed by the home environment. Wiring cable lengths for three network topologies are calculated. The results gained from the next generation home network implemented on the first phase testbed are shown. Finally, our conclusions are given.

Statistical analysis of next generation sequencing data

CERN Document Server

Nettleton, Dan

2014-01-01

Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized med...

Next-generation probabilistic seismicity forecasting

Energy Technology Data Exchange (ETDEWEB)

Hiemer, S.

2014-07-01

novel automated method to investigate the significance of spatial b-value variations. The method incorporates an objective data-driven partitioning scheme, which is based on penalized likelihood estimates. These well-defined criteria avoid the difficult choice of commonly applied spatial mapping parameters, such as grid spacing or size of mapping radii. We construct a seismicity forecast that includes spatial b-value variations and demonstrate our model’s skill and reliability when applied to data from California. All proposed probabilistic seismicity forecasts were subjected to evaluation methods using state of the art algorithms provided by the 'Collaboratory for the Study of Earthquake Predictability' infrastructure. First, we evaluated the statistical agreement between the forecasted and observed rates of target events in terms of number, space and magnitude. Secondly, we assessed the performance of one forecast relative to another. We find that the forecasts presented in this thesis are reliable and show significant skills with respect to established classical forecasts. These next-generation probabilistic seismicity forecasts can thus provide hazard information that are potentially useful in reducing earthquake losses and enhancing community preparedness and resilience. (author)

Next-generation probabilistic seismicity forecasting

International Nuclear Information System (INIS)

Hiemer, S.

2014-01-01

novel automated method to investigate the significance of spatial b-value variations. The method incorporates an objective data-driven partitioning scheme, which is based on penalized likelihood estimates. These well-defined criteria avoid the difficult choice of commonly applied spatial mapping parameters, such as grid spacing or size of mapping radii. We construct a seismicity forecast that includes spatial b-value variations and demonstrate our model’s skill and reliability when applied to data from California. All proposed probabilistic seismicity forecasts were subjected to evaluation methods using state of the art algorithms provided by the 'Collaboratory for the Study of Earthquake Predictability' infrastructure. First, we evaluated the statistical agreement between the forecasted and observed rates of target events in terms of number, space and magnitude. Secondly, we assessed the performance of one forecast relative to another. We find that the forecasts presented in this thesis are reliable and show significant skills with respect to established classical forecasts. These next-generation probabilistic seismicity forecasts can thus provide hazard information that are potentially useful in reducing earthquake losses and enhancing community preparedness and resilience. (author)

ActivitySim: large-scale agent based activity generation for infrastructure simulation

Energy Technology Data Exchange (ETDEWEB)

Gali, Emmanuel [Los Alamos National Laboratory; Eidenbenz, Stephan [Los Alamos National Laboratory; Mniszewski, Sue [Los Alamos National Laboratory; Cuellar, Leticia [Los Alamos National Laboratory; Teuscher, Christof [PORTLAND STATE UNIV

2008-01-01

The United States' Department of Homeland Security aims to model, simulate, and analyze critical infrastructure and their interdependencies across multiple sectors such as electric power, telecommunications, water distribution, transportation, etc. We introduce ActivitySim, an activity simulator for a population of millions of individual agents each characterized by a set of demographic attributes that is based on US census data. ActivitySim generates daily schedules for each agent that consists of a sequence of activities, such as sleeping, shopping, working etc., each being scheduled at a geographic location, such as businesses or private residences that is appropriate for the activity type and for the personal situation of the agent. ActivitySim has been developed as part of a larger effort to understand the interdependencies among national infrastructure networks and their demand profiles that emerge from the different activities of individuals in baseline scenarios as well as emergency scenarios, such as hurricane evacuations. We present the scalable software engineering principles underlying ActivitySim, the socia-technical modeling paradigms that drive the activity generation, and proof-of-principle results for a scenario in the Twin Cities, MN area of 2.6 M agents.

Next generation hyper-scale software and hardware systems for big data analytics

CERN Multimedia

CERN. Geneva

2013-01-01

Building on foundational technologies such as many-core systems, non-volatile memories and photonic interconnects, we describe some current technologies and future research to create real-time, big data analytics, IT infrastructure. We will also briefly describe some of our biologically-inspired software and hardware architecture for creating radically new hyper-scale cognitive computing systems. About the speaker Rich Friedrich is the director of Strategic Innovation and Research Services (SIRS) at HP Labs. In this strategic role, he is responsible for research investments in nano-technology, exascale computing, cyber security, information management, cloud computing, immersive interaction, sustainability, social computing and commercial digital printing. Rich's philosophy is to fuse strategy and inspiration to create compelling capabilities for next generation information devices, systems and services. Using essential insights gained from the metaphysics of innnovation, he effectively leads ...

Frontiers of Radio Astronomy in the 2020s: The Next Generation Very Large Array

Science.gov (United States)

Murphy, Eric Joseph; ngVLA Project Office, ngVLA Science and Technical Advisory Councils, ngVLA Science Working Groups

2018-01-01

This talk will describe the current community-driven science goals, design, and planning status of a future large centimeter radio array: the ‘Next Generation Very Large Array’ (ngVLA). The ngVLA is being developed to observe at wavelengths between ALMA at submm wavelengths, and the future SKA-1 at few centimeter and longer wavelengths, opening a new window on the Universe through ultra-sensitive imaging of thermal line and continuum emission down to milliarcsecond resolution, and unprecedented broad band continuum polarimetric imaging of non-thermal processes. The current design for the array includes 10x more effective collecting area and 10x higher spatial resolution than the current JVLA or ALMA, carefully optimized for operation in the frequency range 10GHz to 50GHz, while still delivering world-leading sensitivity over the entire 1.2GHz to 116 GHz spectrum.With this array, new frontiers in modern astronomy can be reached, including direct imaging and chemical analysis of planet formation in the terrestrial-zone of nearby stars, studies of dust-obscured star formation and the cosmic baryon cycle down to pc-scales in the local Universe, and detailed imaging of molecular gas and galaxy formation into the epoch of reionization. Novel techniques for exploring temporal phenomena on timescales from milliseconds to years will also be implemented. The ngVLA will be situated in the desert southwest of the United States, centered on the current JVLA infrastructure, with multiple antennas anticipated in states/regions adjacent to NM, and in northern Mexico.A recently formed Project Office is working closely with the U.S. and international research community to design the array, and plan its construction beginning mid next decade. Recent significant funding for design and development brought forward by the NSF will enable detailed science case development and technology prototyping/risk reduction before the next U.S astronomy Decadal Survey.

Feasibility of a Networked Air Traffic Infrastructure Validation Environment for Advanced NextGen Concepts

Science.gov (United States)

McCormack, Michael J.; Gibson, Alec K.; Dennis, Noah E.; Underwood, Matthew C.; Miller,Lana B.; Ballin, Mark G.

2013-01-01

Abstract-Next Generation Air Transportation System (NextGen) applications reliant upon aircraft data links such as Automatic Dependent Surveillance-Broadcast (ADS-B) offer a sweeping modernization of the National Airspace System (NAS), but the aviation stakeholder community has not yet established a positive business case for equipage and message content standards remain in flux. It is necessary to transition promising Air Traffic Management (ATM) Concepts of Operations (ConOps) from simulation environments to full-scale flight tests in order to validate user benefits and solidify message standards. However, flight tests are prohibitively expensive and message standards for Commercial-off-the-Shelf (COTS) systems cannot support many advanced ConOps. It is therefore proposed to simulate future aircraft surveillance and communications equipage and employ an existing commercial data link to exchange data during dedicated flight tests. This capability, referred to as the Networked Air Traffic Infrastructure Validation Environment (NATIVE), would emulate aircraft data links such as ADS-B using in-flight Internet and easily-installed test equipment. By utilizing low-cost equipment that is easy to install and certify for testing, advanced ATM ConOps can be validated, message content standards can be solidified, and new standards can be established through full-scale flight trials without necessary or expensive equipage or extensive flight test preparation. This paper presents results of a feasibility study of the NATIVE concept. To determine requirements, six NATIVE design configurations were developed for two NASA ConOps that rely on ADS-B. The performance characteristics of three existing in-flight Internet services were investigated to determine whether performance is adequate to support the concept. Next, a study of requisite hardware and software was conducted to examine whether and how the NATIVE concept might be realized. Finally, to determine a business case

INFRASTRUCTURE

CERN Multimedia

A. Gaddi and P. Tropea

2012-01-01

The CMS Infrastructures teams are preparing for the LS1 activities. A long list of maintenance, consolidation and upgrade projects for CMS Infrastructures is on the table and is being discussed among Technical Coordination and sub-detector representatives. Apart from the activities concerning the cooling infrastructures (see below), two main projects have started: the refurbishment of the SX5 building, from storage area to RP storage and Muon stations laboratory; and the procurement of a new dry-gas (nitrogen and dry air) plant for inner detector flushing. We briefly present here the work done on the first item, leaving the second one for the next CMS Bulletin issue. The SX5 building is entering its third era, from main assembly building for CMS from 2000 to 2007, to storage building from 2008 to 2012, to RP storage and Muon laboratory during LS1 and beyond. A wall of concrete blocks has been erected to limit the RP zone, while the rest of the surface has been split between the ME1/1 and the CSC/DT laborat...

Standardization and quality management in next-generation sequencing.

Science.gov (United States)

Endrullat, Christoph; Glökler, Jörn; Franke, Philipp; Frohme, Marcus

2016-09-01

DNA sequencing continues to evolve quickly even after > 30 years. Many new platforms suddenly appeared and former established systems have vanished in almost the same manner. Since establishment of next-generation sequencing devices, this progress gains momentum due to the continually growing demand for higher throughput, lower costs and better quality of data. In consequence of this rapid development, standardized procedures and data formats as well as comprehensive quality management considerations are still scarce. Here, we listed and summarized current standardization efforts and quality management initiatives from companies, organizations and societies in form of published studies and ongoing projects. These comprise on the one hand quality documentation issues like technical notes, accreditation checklists and guidelines for validation of sequencing workflows. On the other hand, general standard proposals and quality metrics are developed and applied to the sequencing workflow steps with the main focus on upstream processes. Finally, certain standard developments for downstream pipeline data handling, processing and storage are discussed in brief. These standardization approaches represent a first basis for continuing work in order to prospectively implement next-generation sequencing in important areas such as clinical diagnostics, where reliable results and fast processing is crucial. Additionally, these efforts will exert a decisive influence on traceability and reproducibility of sequence data.

Next generation vaccines.

Science.gov (United States)

Riedmann, Eva M

2011-07-01

In February this year, about 100 delegates gathered for three days in Vienna (Austria) for the Next Generation Vaccines conference. The meeting held in the Vienna Hilton Hotel from 23rd-25th February 2011 had a strong focus on biotech and industry. The conference organizer Jacob Fleming managed to put together a versatile program ranging from the future generation of vaccines to manufacturing, vaccine distribution and delivery, to regulatory and public health issues. Carefully selected top industry experts presented first-hand experience and shared solutions for overcoming the latest challenges in the field of vaccinology. The program also included several case study presentations on novel vaccine candidates in different stages of development. An interactive pre-conference workshop as well as interactive panel discussions during the meeting allowed all delegates to gain new knowledge and become involved in lively discussions on timely, interesting and sometimes controversial topics related to vaccines.

NOAA NEXt-Generation RADar (NEXRAD) Products

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level III weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

The Next Generation Science Standards

Science.gov (United States)

Pruitt, Stephen L.

2015-01-01

The Next Generation Science Standards (NGSS Lead States 2013) were released almost two years ago. Work tied to the NGSS, their adoption, and implementation continues to move forward around the country. Stephen L. Pruitt, senior vice president, science, at Achieve, an independent, nonpartisan, nonprofit education reform organization that was a lead…

Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics.

Science.gov (United States)

Shah, Dhaval K

2015-10-01

Increasingly sophisticated protein engineering efforts have been undertaken lately to generate protein therapeutics with desired properties. This has resulted in the discovery of the next generation of protein therapeutics, which include: engineered antibodies, immunoconjugates, bi/multi-specific proteins, antibody mimetic novel scaffolds, and engineered ligands/receptors. These novel protein therapeutics possess unique physicochemical properties and act via a unique mechanism-of-action, which collectively makes their pharmacokinetics (PK) and pharmacodynamics (PD) different than other established biological molecules. Consequently, in order to support the discovery and development of these next generation molecules, it becomes important to understand the determinants controlling their PK/PD. This review discusses the determinants that a PK/PD scientist should consider during the design and development of next generation protein therapeutics. In addition, the role of systems PK/PD models in enabling rational development of the next generation protein therapeutics is emphasized.

The NASA Community Coordinated Modeling Center (CCMC) Next Generation Space Weather Data Warehouse

Science.gov (United States)

Maddox, M. M.; Kuznetsova, M. M.; Pulkkinen, A. A.; Zheng, Y.; Rastaetter, L.; Chulaki, A.; Pembroke, A. D.; Wiegand, C.; Mullinix, R.; Boblitt, J.; Mendoza, A. M. M.; Swindell, M. J., IV; Bakshi, S. S.; Mays, M. L.; Shim, J. S.; Hesse, M.; Collado-Vega, Y. M.; Taktakishvili, A.; MacNeice, P. J.

2014-12-01

The Community Coordinated Modeling Center (CCMC) at NASA Goddard Space Flight Center enables, supports, and performs research and development for next generation space science and space weather models. The CCMC currently hosts a large and expanding collection of state-or-the-art, physics-based space weather models that have been developed by the international research community. There are many tools and services provided by the CCMC that are currently available world-wide, along with the ongoing development of new innovative systems and software for research, discovery, validation, visualization, and forecasting. Over the history of the CCMC's existence, there has been one constant engineering challenge - describing, managing, and disseminating data. To address the challenges that accompany an ever-expanding number of models to support, along with a growing catalog of simulation output - the CCMC is currently developing a flexible and extensible space weather data warehouse to support both internal and external systems and applications. This paper intends to chronicle the evolution and future of the CCMC's data infrastructure, and the current infrastructure re-engineering activities that seek to leverage existing community data model standards like SPASE and the IMPEx Simulation Data Model.

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

addressing, new generation internet. 2. ... required the creation of the next generation of Internet ... IPv6 standards have defined the following Extension headers ..... addresses are represented as x:x:x:x:x:x:x:x, where each x is the hexadecimal ...

The European cooperative approach to securing critical information infrastructure.

Science.gov (United States)

Purser, Steve

2011-10-01

This paper provides an overview of the EU approach to securing critical information infrastructure, as defined in the Action Plan contained in the Commission Communication of March 2009, entitled 'Protecting Europe from large-scale cyber-attacks and disruptions: enhancing preparedness, security and resilience' and further elaborated by the Communication of May 2011 on critical Information infrastructure protection 'Achievements and next steps: towards global cyber-security'. After explaining the need for pan-European cooperation in this area, the CIIP Action Plan is explained in detail. Finally, the current state of progress is summarised together with the proposed next steps.

Next-generation wireless technologies 4G and beyond

CERN Document Server

Chilamkurti, Naveen; Chaouchi, Hakima

2013-01-01

This comprehensive text/reference examines the various challenges to secure, efficient and cost-effective next-generation wireless networking. Topics and features: presents the latest advances, standards and technical challenges in a broad range of emerging wireless technologies; discusses cooperative and mesh networks, delay tolerant networks, and other next-generation networks such as LTE; examines real-world applications of vehicular communications, broadband wireless technologies, RFID technology, and energy-efficient wireless communications; introduces developments towards the 'Internet o

Next Generation Surveillance System (NGSS): Field Implementation & Associated Developments

International Nuclear Information System (INIS)

Hadfi, G.; John, M.; Liguori, C.; Moeslinger, M.; Murray, J.; Rocchi, S.

2015-01-01

The NGSS is the product of more than five years of development between the IAEA, other Inspectorates, Member State Support Programmes, and commercial vendors. The product of these efforts has now matured into the field implementation stage. This paper details the goals, achievements and challenges experienced during the implementation phase and associated developments of the project. NGSS procurement was subject to the IAEA's stringent procurement policies involving independent third party assessments to assure supplier reliability and competitive pricing controls. More than 1200 surveillance cameras currently installed in facilities worldwide will be replaced by NGSS within the next 4 to 5 years. Joint use procedures have been established taking advantage of the technical capabilities integrated within the design of the NGSS which allow for multiple inspectorates and States to securely and independently share and review data. Utilization of outdated facility infrastructure poses many challenges to implementation efforts; these were met with innovative technical solutions to take advantage of cost benefits allowed in its re-utilization. New partnerships were established with Member States, regulatory bodies and nuclear power plant operators for new nuclear facilities under construction, to address infrastructural requirements spanning the next half century. The utilization of the IAEA's well-established PKI infrastructure enhances data security features and usability with regard to data sharing, key management and joint use of the NGSS system data. Embedded inventory reporting capability aids electronic inventory verification of safeguards equipment, simplifying accountability, configuration control and troubleshooting of installed systems. Current developments ongoing within the project include the design of hardware and software components for use of the system in special applications (e.g., underwater and outdoor installations, mechanism to

Informing the next nuclear generation - how does the Ginna plant branch do it?

International Nuclear Information System (INIS)

Saavedra, A.

1995-01-01

Most of us are familiar with the latest advertising phrase, ''Our children are our future.'' This phrase has been used in so many instances - from concerns about waste, Social Security, and the federal deficit to drug abuse and violence. One more area can be added to the list and advertised nuclear power. Since the establishment of the Ginna plant branch (GPB) in 1992, our target audience has been the next nuclear generation (our children), but our vehicle for dissemination has been the current generation (the adults). Have you ever thought about how often your opinions affect the children you come in contact with? One of GPB's goals is to provide as much information as possible to teachers, neighbors, and civic organizations of our community so that there is a nuclear future that can be carried on by the next generation

A Systems Engineering Framework for Design, Construction and Operation of the Next Generation Nuclear Plant

International Nuclear Information System (INIS)

Edward J. Gorski; Charles V. Park; Finis H. Southworth

2004-01-01

Not since the International Space Station has a project of such wide participation been proposed for the United States. Ten countries, the European Union, universities, Department of Energy (DOE) laboratories, and industry will participate in the research and development, design, construction and/or operation of the fourth generation of nuclear power plants with a demonstration reactor to be built at a DOE site and operational by the middle of the next decade. This reactor will be like no other. The Next Generation Nuclear Plant (NGNP) will be passively safe, economical, highly efficient, modular, proliferation resistant, and sustainable. In addition to electrical generation, the NGNP will demonstrate efficient and cost effective generation of hydrogen to support the President's Hydrogen Initiative. To effectively manage this multi-organizational and technologically complex project, systems engineering techniques and processes will be used extensively to ensure delivery of the final product. The technological and organizational challenges are complex. Research and development activities are required, material standards require development, hydrogen production, storage and infrastructure requirements are not well developed, and the Nuclear Regulatory Commission may further define risk-informed/performance-based approach to licensing. Detailed design and development will be challenged by the vast cultural and institutional differences across the participants. Systems engineering processes must bring the technological and organizational complexity together to ensure successful product delivery. This paper will define the framework for application of systems engineering to this $1.5B - $1.9B project

Next Generation of Photovoltaics New Concepts

CERN Document Server

Vega, Antonio; López, Antonio

2012-01-01

This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells.

Next generation of photovoltaics. New concepts

Energy Technology Data Exchange (ETDEWEB)

Cristobal Lopez, Ana Belen; Marti Vega, Antonio; Luque Lopez, Antonio (eds.) [Univ. Politecnica de Madrid (Spain). Inst. de Energia Solar E.T.S.I. Telecomunicacion

2012-07-01

This book presents new concepts for a next generation of PV. Among these concepts are: Multijunction solar cells, multiple excitation solar cells (or how to take benefit of high energy photons for the creation of more than one electron hole-pair), intermediate band solar cells (or how to take advantage of below band-gap energy photons) and related technologies (for quantum dots, nitrides, thin films), advanced light management approaches (plasmonics). Written by world-class experts in next generation photovoltaics this book is an essential reference guide accessible to both beginners and experts working with solar cell technology. The book deeply analyzes the current state-of-the-art of the new photovoltaic approaches and outlines the implementation paths of these advanced devices. Topics addressed range from the fundamentals to the description of state-of-the-art of the new types of solar cells. (orig.)

Galaxy LIMS for next-generation sequencing

NARCIS (Netherlands)

Scholtalbers, J.; Rossler, J.; Sorn, P.; Graaf, J. de; Boisguerin, V.; Castle, J.; Sahin, U.

2013-01-01

SUMMARY: We have developed a laboratory information management system (LIMS) for a next-generation sequencing (NGS) laboratory within the existing Galaxy platform. The system provides lab technicians standard and customizable sample information forms, barcoded submission forms, tracking of input

Next-generation mid-infrared sources

Science.gov (United States)

Jung, D.; Bank, S.; Lee, M. L.; Wasserman, D.

2017-12-01

to provide a survey of the current state of the art for mid-IR sources, but instead looks primarily to provide a picture of potential next-generation optical and optoelectronic materials systems for mid-IR light generation.

SDN-NGenIA, a software defined next generation integrated architecture for HEP and data intensive science

Science.gov (United States)

Balcas, J.; Hendricks, T. W.; Kcira, D.; Mughal, A.; Newman, H.; Spiropulu, M.; Vlimant, J. R.

2017-10-01

The SDN Next Generation Integrated Architecture (SDN-NGeNIA) project addresses some of the key challenges facing the present and next generations of science programs in HEP, astrophysics, and other fields, whose potential discoveries depend on their ability to distribute, process and analyze globally distributed Petascale to Exascale datasets. The SDN-NGenIA system under development by Caltech and partner HEP and network teams is focused on the coordinated use of network, computing and storage infrastructures, through a set of developments that build on the experience gained in recently completed and previous projects that use dynamic circuits with bandwidth guarantees to support major network flows, as demonstrated across LHC Open Network Environment [1] and in large scale demonstrations over the last three years, and recently integrated with PhEDEx and Asynchronous Stage Out data management applications of the CMS experiment at the Large Hadron Collider. In addition to the general program goals of supporting the network needs of the LHC and other science programs with similar needs, a recent focus is the use of the Leadership HPC facility at Argonne National Lab (ALCF) for data intensive applications.

Next-generation Digital Earth.

Science.gov (United States)

Goodchild, Michael F; Guo, Huadong; Annoni, Alessandro; Bian, Ling; de Bie, Kees; Campbell, Frederick; Craglia, Max; Ehlers, Manfred; van Genderen, John; Jackson, Davina; Lewis, Anthony J; Pesaresi, Martino; Remetey-Fülöpp, Gábor; Simpson, Richard; Skidmore, Andrew; Wang, Changlin; Woodgate, Peter

2012-07-10

A speech of then-Vice President Al Gore in 1998 created a vision for a Digital Earth, and played a role in stimulating the development of a first generation of virtual globes, typified by Google Earth, that achieved many but not all the elements of this vision. The technical achievements of Google Earth, and the functionality of this first generation of virtual globes, are reviewed against the Gore vision. Meanwhile, developments in technology continue, the era of "big data" has arrived, the general public is more and more engaged with technology through citizen science and crowd-sourcing, and advances have been made in our scientific understanding of the Earth system. However, although Google Earth stimulated progress in communicating the results of science, there continue to be substantial barriers in the public's access to science. All these factors prompt a reexamination of the initial vision of Digital Earth, and a discussion of the major elements that should be part of a next generation.

Special Issue: Next Generation DNA Sequencing

Directory of Open Access Journals (Sweden)

Paul Richardson

2010-10-01

Full Text Available Next Generation Sequencing (NGS refers to technologies that do not rely on traditional dideoxy-nucleotide (Sanger sequencing where labeled DNA fragments are physically resolved by electrophoresis. These new technologies rely on different strategies, but essentially all of them make use of real-time data collection of a base level incorporation event across a massive number of reactions (on the order of millions versus 96 for capillary electrophoresis for instance. The major commercial NGS platforms available to researchers are the 454 Genome Sequencer (Roche, Illumina (formerly Solexa Genome analyzer, the SOLiD system (Applied Biosystems/Life Technologies and the Heliscope (Helicos Corporation. The techniques and different strategies utilized by these platforms are reviewed in a number of the papers in this special issue. These technologies are enabling new applications that take advantage of the massive data produced by this next generation of sequencing instruments. [...

Next-Generation Sequencing of Tubal Intraepithelial Carcinomas.

Science.gov (United States)

McDaniel, Andrew S; Stall, Jennifer N; Hovelson, Daniel H; Cani, Andi K; Liu, Chia-Jen; Tomlins, Scott A; Cho, Kathleen R

2015-11-01

High-grade serous carcinoma (HGSC) is the most prevalent and lethal form of ovarian cancer. HGSCs frequently arise in the distal fallopian tubes rather than the ovary, developing from small precursor lesions called serous tubal intraepithelial carcinomas (TICs, or more specifically, STICs). While STICs have been reported to harbor TP53 mutations, detailed molecular characterizations of these lesions are lacking. We performed targeted next-generation sequencing (NGS) on formalin-fixed, paraffin-embedded tissue from 4 women, 2 with HGSC and 2 with uterine endometrioid carcinoma (UEC) who were diagnosed as having synchronous STICs. We detected concordant mutations in both HGSCs with synchronous STICs, including TP53 mutations as well as assumed germline BRCA1/2 alterations, confirming a clonal association between these lesions. Next-generation sequencing confirmed the presence of a STIC clonally unrelated to 1 case of UEC, and NGS of the other tubal lesion diagnosed as a STIC unexpectedly supported the lesion as a micrometastasis from the associated UEC. We demonstrate that targeted NGS can identify genetic alterations in minute lesions, such as TICs, and confirm TP53 mutations as early driving events for HGSC. Next-generation sequencing also demonstrated unexpected associations between presumed STICs and synchronous carcinomas, providing evidence that some TICs are actually metastases rather than HGSC precursors.

Next Generation NASA Initiative for Space Geodesy

Science.gov (United States)

Merkowitz, S. M.; Desai, S.; Gross, R. S.; Hilliard, L.; Lemoine, F. G.; Long, J. L.; Ma, C.; McGarry J. F.; Murphy, D.; Noll, C. E.;

Implications of generator siting for CO2 pipeline infrastructure

International Nuclear Information System (INIS)

Newcomer, Adam; Apt, Jay

2008-01-01

The location of a new electric power generation system with carbon capture and sequestration (CCS) affects the profitability of the facility and determines the amount of infrastructure required to connect the plant to the larger world. Using a probabilistic analysis, we examine where a profit-maximizing power producer would locate a new generator with carbon capture in relation to a fuel source, electric load, and CO 2 sequestration site. Based on models of costs for transmission lines, CO 2 pipelines, and fuel transportation, we find that it is always preferable to locate a CCS power facility nearest the electric load, reducing the losses and costs of bulk electricity transmission. This result suggests that a power system with significant amounts of CCS requires a very large CO 2 pipeline infrastructure

Next-generation fiber lasers enabled by high-performance components

Science.gov (United States)

Kliner, D. A. V.; Victor, B.; Rivera, C.; Fanning, G.; Balsley, D.; Farrow, R. L.; Kennedy, K.; Hampton, S.; Hawke, R.; Soukup, E.; Reynolds, M.; Hodges, A.; Emery, J.; Brown, A.; Almonte, K.; Nelson, M.; Foley, B.; Dawson, D.; Hemenway, D. M.; Urbanek, W.; DeVito, M.; Bao, L.; Koponen, J.; Gross, K.

2018-02-01

Next-generation industrial fiber lasers enable challenging applications that cannot be addressed with legacy fiber lasers. Key features of next-generation fiber lasers include robust back-reflection protection, high power stability, wide power tunability, high-speed modulation and waveform generation, and facile field serviceability. These capabilities are enabled by high-performance components, particularly pump diodes and optical fibers, and by advanced fiber laser designs. We summarize the performance and reliability of nLIGHT diodes, fibers, and next-generation industrial fiber lasers at power levels of 500 W - 8 kW. We show back-reflection studies with up to 1 kW of back-reflected power, power-stability measurements in cw and modulated operation exhibiting sub-1% stability over a 5 - 100% power range, and high-speed modulation (100 kHz) and waveform generation with a bandwidth 20x higher than standard fiber lasers. We show results from representative applications, including cutting and welding of highly reflective metals (Cu and Al) for production of Li-ion battery modules and processing of carbon fiber reinforced polymers.

Novel nanostructures for next generation dye-sensitized solar cells

KAUST Repository

Tétreault, Nicolas

2012-01-01

Herein, we review our latest advancements in nanostructured photoanodes for next generation photovoltaics in general and dye-sensitized solar cells in particular. Bottom-up self-assembly techniques are developed to fabricate large-area 3D nanostructures that enable enhanced charge extraction and light harvesting through optical scattering or photonic crystal effects to improve photocurrent, photovoltage and fill factor. Using generalized techniques to fabricate specialized nanostructures enables specific optoelectronic and physical characteristics like conduction, charge extraction, injection, recombination and light harvesting but also helps improve mechanical flexibility and long-term stability in low cost materials. © 2012 The Royal Society of Chemistry.

Mobile location services over the next generation IP core network

DEFF Research Database (Denmark)

Thongthammachart, Saowanee; Olesen, Henning

2003-01-01

network is changing from circuit-switched to packet-switched technology and evolving to an IP core network based on IPv6. The IP core network will allow all IP devices to be connected seamlessly. Due to the movement detection mechanism of Mobile IPv6, mobile terminals will periodically update....... The concept of mobile location services over the next generation IP networks is described. We also discuss the effectiveness of the short-range wireless network regarding a mobile user's position inside buildings and hotspot areas....

Innovations in Nuclear Infrastructure and Education

Energy Technology Data Exchange (ETDEWEB)

John Bernard

2010-12-13

The decision to implement the Innovation in Nuclear Infrastructure and Engineering Program (INIE) was an important first step towards ensuring that the United States preserves its worldwide leadership role in the field of nuclear science and engineering. Prior to INIE, university nuclear science and engineering programs were waning, undergraduate student enrollment was down, university research reactors were being shut down, while others faced the real possibility of closure. For too long, cutting edge research in the areas of nuclear medicine, neutron scattering, radiochemistry, and advanced materials was undervalued and therefore underfunded. The INIE program corrected this lapse in focus and direction and started the process of drawing a new blueprint with positive goals and objectives that supports existing as well the next generation of educators, students and researchers.

Innovations in Nuclear Infrastructure and Education

International Nuclear Information System (INIS)

Bernard, John

2010-01-01

The decision to implement the Innovation in Nuclear Infrastructure and Engineering Program (INIE) was an important first step towards ensuring that the United States preserves its worldwide leadership role in the field of nuclear science and engineering. Prior to INIE, university nuclear science and engineering programs were waning, undergraduate student enrollment was down, university research reactors were being shut down, while others faced the real possibility of closure. For too long, cutting edge research in the areas of nuclear medicine, neutron scattering, radiochemistry, and advanced materials was undervalued and therefore underfunded. The INIE program corrected this lapse in focus and direction and started the process of drawing a new blueprint with positive goals and objectives that supports existing as well the next generation of educators, students and researchers.

CIMS: A FRAMEWORK FOR INFRASTRUCTURE INTERDEPENDENCY MODELING AND ANALYSIS

Energy Technology Data Exchange (ETDEWEB)

Donald D. Dudenhoeffer; May R. Permann; Milos Manic

2006-12-01

Today’s society relies greatly upon an array of complex national and international infrastructure networks such as transportation, utilities, telecommunication, and even financial networks. While modeling and simulation tools have provided insight into the behavior of individual infrastructure networks, a far less understood area is that of the interrelationships among multiple infrastructure networks including the potential cascading effects that may result due to these interdependencies. This paper first describes infrastructure interdependencies as well as presenting a formalization of interdependency types. Next the paper describes a modeling and simulation framework called CIMS© and the work that is being conducted at the Idaho National Laboratory (INL) to model and simulate infrastructure interdependencies and the complex behaviors that can result.

Compact 2100 nm laser diode module for next-generation DIRCM

Science.gov (United States)

Dvinelis, Edgaras; Greibus, Mindaugas; TrinkÅ«nas, Augustinas; NaujokaitÄ--, Greta; Vizbaras, Augustinas; Vizbaras, Dominykas; Vizbaras, Kristijonas

2017-10-01

Compact high-power 2100 nm laser diode module for next-generation directional infrared countermeasure (DIRCM) systems is presented. Next-generation DIRCM systems require compact, light-weight and robust laser modules which could provide intense IR light emission capable of disrupting the tracking sensor of heat-seeking missile. Currently used solid-state and fiber laser solutions for mid-IR band are bulky and heavy making them difficult to implement in smaller form-factor DIRCM systems. Recent development of GaSb laser diode technology greatly improved optical output powers and efficiencies of laser diodes working in 1900 - 2450 nm band [1] while also maintaining very attractive size, weight, power consumption and cost characteristics. 2100 nm laser diode module presented in this work performance is based on high-efficiency broad emitting area GaSb laser diode technology. Each laser diode emitter is able to provide 1 W of CW output optical power with working point efficiency up to 20% at temperature of 20 °C. For output beam collimation custom designed fast-axis collimator and slow-axis collimator lenses were used. These lenses were actively aligned and attached using UV epoxy curing. Total 2 emitters stacked vertically were used in 2100 nm laser diode module. Final optical output power of the module goes up to 2 W at temperature of 20 °C. Total dimensions of the laser diode module are 35 x 25 x 16 mm (L x W x H) with a weight of 28 grams. Finally output beam is bore-sighted to mechanical axes of the module housing allowing for easy integration into next-generation DIRCM systems.

Next-Generation Intensity-Duration-Frequency Curves for Hydrologic Design in Snow-Dominated Environments

Science.gov (United States)

Yan, Hongxiang; Sun, Ning; Wigmosta, Mark; Skaggs, Richard; Hou, Zhangshuan; Leung, Ruby

2018-02-01

There is a renewed focus on the design of infrastructure resilient to extreme hydrometeorological events. While precipitation-based intensity-duration-frequency (IDF) curves are commonly used as part of infrastructure design, a large percentage of peak runoff events in snow-dominated regions are caused by snowmelt, particularly during rain-on-snow (ROS) events. In these regions, precipitation-based IDF curves may lead to substantial overestimation/underestimation of design basis events and subsequent overdesign/underdesign of infrastructure. To overcome this deficiency, we proposed next-generation IDF (NG-IDF) curves, which characterize the actual water reaching the land surface. We compared NG-IDF curves to standard precipitation-based IDF curves for estimates of extreme events at 376 Snowpack Telemetry (SNOTEL) stations across the western United States that each had at least 30 years of high-quality records. We found standard precipitation-based IDF curves at 45% of the stations were subject to underdesign, many with significant underestimation of 100 year extreme events, for which the precipitation-based IDF curves can underestimate water potentially available for runoff by as much as 125% due to snowmelt and ROS events. The regions with the greatest potential for underdesign were in the Pacific Northwest, the Sierra Nevada Mountains, and the Middle and Southern Rockies. We also found the potential for overdesign at 20% of the stations, primarily in the Middle Rockies and Arizona mountains. These results demonstrate the need to consider snow processes in the development of IDF curves, and they suggest use of the more robust NG-IDF curves for hydrologic design in snow-dominated environments.

Next Generation Intelligent Wireless Infrastructure

DEFF Research Database (Denmark)

Toftegaard, Thomas Skjødeberg

2010-01-01

Given the commercial success of wireless technologies that has already taken place over the last couple of decades, with a global mobile communication penetration beyond 3 billion subscribers as well as the enormous success of wireless data communication through IEEE 802.11x and Bluetooth, people...

New materials for next-generation commercial transports

National Research Council Canada - National Science Library

Committee on New Materials for Advanced Civil Aircraft, Commission on Engineering and Technical Systems, National Research Council

... civil aircraft throughout their service life. The committee investigated the new materials and structural concepts that are likely to be incorporated into next generation commercial aircraft and the factors influencing application decisions...

Preparation of next generation set of group cross sections. 3

International Nuclear Information System (INIS)

Kaneko, Kunio

2002-03-01

This fiscal year, based on the examination result about the evaluation energy range of heavy element unresolved resonance cross sections, the upper energy limit of the energy range, where ultra-fine group cross sections are produced, was raised to 50 keV, and an improvement of the group cross section processing system was promoted. At the same time, reflecting the result of studies carried out till now, a function producing delayed neutron data was added to the general-purpose group cross section processing system , thus the preparation of general purpose group cross section processing system has been completed. On the other hand, the energy structure, data constitution and data contents of next generation group cross section set were determined, and the specification of a 151 groups next generation group cross section set was defined. Based on the above specification, a concrete library format of the next generation cross section set has been determined. After having carried out the above-described work, using the general-purpose group cross section processing system , which was complete in this study, with use of the JENDL-3. 2 evaluated nuclear data, the 151 groups next generation group cross section of 92 nuclides and the ultra fine group resonance cross section library for 29 nuclides have been prepared. Utilizing the 151 groups next generation group cross section set and the ultra-fine group resonance cross-section library, a bench mark test calculation of fast reactors has been performed by using an advanced lattice calculation code. It was confirmed, by comparing the calculation result with a calculation result of continuous energy Monte Carlo code, that the 151 groups next generation cross section set has sufficient accuracy. (author)

Next generation information systems

Energy Technology Data Exchange (ETDEWEB)

Limback, Nathan P [Los Alamos National Laboratory; Medina, Melanie A [Los Alamos National Laboratory; Silva, Michelle E [Los Alamos National Laboratory

2010-01-01

The Information Systems Analysis and Development (ISAD) Team of the Safeguards Systems Group at Los Alamos National Laboratory (LANL) has been developing web based information and knowledge management systems for sixteen years. Our vision is to rapidly and cost effectively provide knowledge management solutions in the form of interactive information systems that help customers organize, archive, post and retrieve nonproliferation and safeguards knowledge and information vital to their success. The team has developed several comprehensive information systems that assist users in the betterment and growth of their organizations and programs. Through our information systems, users are able to streamline operations, increase productivity, and share and access information from diverse geographic locations. The ISAD team is also producing interactive visual models. Interactive visual models provide many benefits to customers beyond the scope of traditional full-scale modeling. We have the ability to simulate a vision that a customer may propose, without the time constraints of traditional engineering modeling tools. Our interactive visual models can be used to access specialized training areas, controlled areas, and highly radioactive areas, as well as review site-specific training for complex facilities, and asset management. Like the information systems that the ISAD team develops, these models can be shared and accessed from any location with access to the internet. The purpose of this paper is to elaborate on the capabilities of information systems and interactive visual models as well as consider the possibility of combining the two capabilities to provide the next generation of infonnation systems. The collection, processing, and integration of data in new ways can contribute to the security of the nation by providing indicators and information for timely action to decrease the traditional and new nuclear threats. Modeling and simulation tied to comprehensive

Looking toward to the next-generation space weather forecast system. Comments former a former space weather forecaster

International Nuclear Information System (INIS)

Tomita, Fumihiko

1999-01-01

In the 21st century, man's space-based activities will increase significantly and many kinds of space utilization technologies will assume a vital role in the infrastructure, creating new businesses, securing the global environment, contributing much to human welfare in the world. Communications Research Laboratory (CRL) has been contributing to the safety of human activity in space and to the further understanding of the solar terrestrial environment through the study of space weather, including the upper atmosphere, magnetosphere, interplanetary space, and the sun. The next-generation Space Weather Integrated Monitoring System (SWIMS) for future space activities based on the present international space weather forecasting system is introduced in this paper. (author)

A National Demonstration Project Building the Next Generation

International Nuclear Information System (INIS)

Keuter, Dan; Hughey, Kenneth; Melancon, Steve; Quinn, Edward 'Ted'

2002-01-01

The U.S., and the world to a greater extent, needs more electrical power generating plants. In the U.S. alone some estimates say that over the next 20 years more than 400,000 MWe of new generation will be needed. This in a period when domestic oil and gas production decreases while consumption increases. Consequently, the U.S. grows more and more dependent on foreign energy sources today importing approximately 60% of our needs. Consider also that the U.S., once the world leader in all nuclear technology, no long leads the world in this technology and each day that goes by the U.S. nuclear infrastructure becomes less and less robust. Due to its improved safety, reliability/economics and emission free generation nuclear power is once more seen as an important energy source in many countries. In 2000, the number of operating nuclear power plants worldwide increased to 438, with 36 new plants under construction. Unfortunately, no new reactor orders have been placed in the US since 1979. When one considers national issues such as reducing environmental emissions, reallocation and conservation of limited natural resources and domestic energy security, the need for new nuclear generation is essential. While the hurdles facing the deployment of new nuclear generation in the U.S. are certainly formidable, the consequences of inaction in this regard are intolerable. In partnership with industry, the Department of Energy should move forward with an aggressive effort in support of deployment of an advanced nuclear power reactor incorporating state-of-the-art safety and proliferation resistant systems. This effort should be structured so as to significantly advance the timetable by which the systems would be available for commercial deployment by taking advantage of ongoing efforts currently underway at DOE and industry. The effort should be sequenced, to the extent possible, so that it can best reflect, both with respect to schedule and capability, the evolving national

Next Generation Nuclear Plant Project Evaluation of Siting a HTGR Co-generation Plant on an Operating Commercial Nuclear Power Plant Site

International Nuclear Information System (INIS)

Demick, L.E.

2011-01-01

This paper summarizes an evaluation by the Idaho National Laboratory (INL) Next Generation Nuclear Plant (NGNP) Project of siting a High Temperature Gas-cooled Reactor (HTGR) plant on an existing nuclear plant site that is located in an area of significant industrial activity. This is a co-generation application in which the HTGR Plant will be supplying steam and electricity to one or more of the nearby industrial plants.

Next Generation Nuclear Plant Project Evaluation of Siting a HTGR Co-generation Plant on an Operating Commercial Nuclear Power Plant Site

Energy Technology Data Exchange (ETDEWEB)

L.E. Demick

2011-10-01

This paper summarizes an evaluation by the Idaho National Laboratory (INL) Next Generation Nuclear Plant (NGNP) Project of siting a High Temperature Gas-cooled Reactor (HTGR) plant on an existing nuclear plant site that is located in an area of significant industrial activity. This is a co-generation application in which the HTGR Plant will be supplying steam and electricity to one or more of the nearby industrial plants.

Benefits of Sharing Information from Commercial Airborne Forward-Looking Sensors in the Next Generation Air Transportation System

Science.gov (United States)

Schaffner, Philip R.; Harrah, Steven; Neece, Robert T.

2012-01-01

The air transportation system of the future will need to support much greater traffic densities than are currently possible, while preserving or improving upon current levels of safety. Concepts are under development to support a Next Generation Air Transportation System (NextGen) that by some estimates will need to support up to three times current capacity by the year 2025. Weather and other atmospheric phenomena, such as wake vortices and volcanic ash, constitute major constraints on airspace system capacity and can present hazards to aircraft if encountered. To support safe operations in the NextGen environment advanced systems for collection and dissemination of aviation weather and environmental information will be required. The envisioned NextGen Network Enabled Weather (NNEW) infrastructure will be a critical component of the aviation weather support services, providing access to a common weather picture for all system users. By taking advantage of Network Enabled Operations (NEO) capabilities, a virtual 4-D Weather Data Cube with aviation weather information from many sources will be developed. One new source of weather observations may be airborne forward-looking sensors, such as the X-band weather radar. Future sensor systems that are the subject of current research include advanced multi-frequency and polarimetric radar, a variety of Lidar technologies, and infrared imaging spectrometers.

Estabilishing requirements for the next generation of pressurized water reactors--reducing the uncertainty

International Nuclear Information System (INIS)

Chernock, W.P.; Corcoran, W.R.; Rasin, W.H.; Stahlkopf, K.E.

1987-01-01

The Electric Power Research Institute is managing a major effort to establish requirements for the next generation of U.S. light water reactors. This effort is the vital first step in preserving the viability of the nuclear option to contribute to meet U.S. national electric power capacity needs in the next century. Combustion Engineering, Inc. and Duke Power Company formed a team to participate in the EPRI program which is guided by a Utility Steering committee consisting of experienced utility technical executives. A major thrust of the program is to reduce the uncertainties which would be faced by the utility executives in choosing the nuclear option. The uncertainties to be reduced include those related to safety, economic, operational, and regulatory aspects of advanced light water reactors. This paper overviews the Requirements Document program as it relates to the U.S. Advanced Light Water Reactor (ALWR) effort in reducing these uncertainties and reports the status of efforts to establish requirements for the next generation of pressurized water reactors. It concentrates on progress made in reducing the uncertainties which would deter selection of the nuclear option for contributing to U.S. national electric power capacity needs in the next century and updates previous reports in the same area. (author)

Implementing the Next Generation Science Standards

Science.gov (United States)

Penuel, William R.; Harris, Christopher J.; DeBarger, Angela Haydel

2015-01-01

The Next Generation Science Standards embody a new vision for science education grounded in the idea that science is both a body of knowledge and a set of linked practices for developing knowledge. The authors describe strategies that they suggest school and district leaders consider when designing strategies to support NGSS implementation.

Production of the next-generation library virtual tour

Science.gov (United States)

Duncan, James M.; Roth, Linda K.

2001-01-01

While many libraries offer overviews of their services through their Websites, only a small number of health sciences libraries provide Web-based virtual tours. These tours typically feature photographs of major service areas along with textual descriptions. This article describes the process for planning, producing, and implementing a next-generation virtual tour in which a variety of media elements are integrated: photographic images, 360-degree “virtual reality” views, textual descriptions, and contextual floor plans. Hardware and software tools used in the project are detailed, along with a production timeline and budget, tips for streamlining the process, and techniques for improving production. This paper is intended as a starting guide for other libraries considering an investment in such a project. PMID:11837254

Next-Generation Sequencing Platforms

Science.gov (United States)

Mardis, Elaine R.

2013-06-01

Automated DNA sequencing instruments embody an elegant interplay among chemistry, engineering, software, and molecular biology and have built upon Sanger's founding discovery of dideoxynucleotide sequencing to perform once-unfathomable tasks. Combined with innovative physical mapping approaches that helped to establish long-range relationships between cloned stretches of genomic DNA, fluorescent DNA sequencers produced reference genome sequences for model organisms and for the reference human genome. New types of sequencing instruments that permit amazing acceleration of data-collection rates for DNA sequencing have been developed. The ability to generate genome-scale data sets is now transforming the nature of biological inquiry. Here, I provide an historical perspective of the field, focusing on the fundamental developments that predated the advent of next-generation sequencing instruments and providing information about how these instruments work, their application to biological research, and the newest types of sequencers that can extract data from single DNA molecules.

Unbundling in Current Broadband and Next-Generation Ultra-Broadband Access Networks

Science.gov (United States)

Gaudino, Roberto; Giuliano, Romeo; Mazzenga, Franco; Valcarenghi, Luca; Vatalaro, Francesco

2014-05-01

This article overviews the methods that are currently under investigation for implementing multi-operator open-access/shared-access techniques in next-generation access ultra-broadband architectures, starting from the traditional "unbundling-of-the-local-loop" techniques implemented in legacy twisted-pair digital subscriber line access networks. A straightforward replication of these copper-based unbundling-of-the-local-loop techniques is usually not feasible on next-generation access networks, including fiber-to-the-home point-to-multipoint passive optical networks. To investigate this issue, the article first gives a concise description of traditional copper-based unbundling-of-the-local-loop solutions, then focalizes on both next-generation access hybrid fiber-copper digital subscriber line fiber-to-the-cabinet scenarios and on fiber to the home by accounting for the mix of regulatory and technological reasons driving the next-generation access migration path, focusing mostly on the European situation.

Mobile e-Learning for Next Generation Communication Environment

Science.gov (United States)

Wu, Tin-Yu; Chao, Han-Chieh

2008-01-01

This article develops an environment for mobile e-learning that includes an interactive course, virtual online labs, an interactive online test, and lab-exercise training platform on the fourth generation mobile communication system. The Next Generation Learning Environment (NeGL) promotes the term "knowledge economy." Inter-networking…

The next generation safeguards initiative

International Nuclear Information System (INIS)

Tobey, William

2008-01-01

NGSI or the Next Generation Safeguards Initiative is designed to revitalize the U.S. safeguards technical base, as well as invest in human resources, and to mobilize our primary asset - the U.S. National Laboratories - as well as industry and academia to restore capabilities. While NGSI is a U.S. effort it is intended to serve as a catalyst for a much broader commitment to international safeguards in partnership with the IAEA and other countries. Initiatives over the last years include such as the Proliferation Security Initiative, UN Security Council Resolution 1540, the Global Initiative to Combat Nuclear Terrorism, and initiatives of the G-8 and NSG to discourage the spread of enrichment and reprocessing. NGSI augments this agenda by providing a means to strengthen the technical and political underpinnings of IAEA safeguards. Priorities and envisioned activities under NGSI are the following. (1) Cooperation with IAEA and others to promote universal adoption of safeguards agreements and the Additional Protocol including greater information sharing between member states and the IAEA, investigation of weaponization and procurement activities, and options to strengthen the state-level approach to safeguards. (2) NGSI anticipates the deployment of new types of reactors and fuel cycle facilities, as well as the need to use limited safeguards resources effectively and efficiently, especially in plants that pose the largest burden specifically complex, bulk-handling facilities. (3) NGSI will encourage a generational improvement in current safeguards technologies including improvement of precision and speed of nuclear measurements, performance of real-time process monitoring and surveillance in unattended mode, enabling in-field, pre-screening and analysis of nuclear and environmental samples, and collection, integration, analysis and archiving safeguards-relevant information from all available sources.(4) NGSI will address human capital management. Training and

A Window Into Clinical Next-Generation Sequencing-Based Oncology Testing Practices.

Science.gov (United States)

Nagarajan, Rakesh; Bartley, Angela N; Bridge, Julia A; Jennings, Lawrence J; Kamel-Reid, Suzanne; Kim, Annette; Lazar, Alexander J; Lindeman, Neal I; Moncur, Joel; Rai, Alex J; Routbort, Mark J; Vasalos, Patricia; Merker, Jason D

2017-12-01

- Detection of acquired variants in cancer is a paradigm of precision medicine, yet little has been reported about clinical laboratory practices across a broad range of laboratories. - To use College of American Pathologists proficiency testing survey results to report on the results from surveys on next-generation sequencing-based oncology testing practices. - College of American Pathologists proficiency testing survey results from more than 250 laboratories currently performing molecular oncology testing were used to determine laboratory trends in next-generation sequencing-based oncology testing. - These presented data provide key information about the number of laboratories that currently offer or are planning to offer next-generation sequencing-based oncology testing. Furthermore, we present data from 60 laboratories performing next-generation sequencing-based oncology testing regarding specimen requirements and assay characteristics. The findings indicate that most laboratories are performing tumor-only targeted sequencing to detect single-nucleotide variants and small insertions and deletions, using desktop sequencers and predesigned commercial kits. Despite these trends, a diversity of approaches to testing exists. - This information should be useful to further inform a variety of topics, including national discussions involving clinical laboratory quality systems, regulation and oversight of next-generation sequencing-based oncology testing, and precision oncology efforts in a data-driven manner.

Next-generation mammalian genetics toward organism-level systems biology.

Science.gov (United States)

Susaki, Etsuo A; Ukai, Hideki; Ueda, Hiroki R

2017-01-01

Organism-level systems biology in mammals aims to identify, analyze, control, and design molecular and cellular networks executing various biological functions in mammals. In particular, system-level identification and analysis of molecular and cellular networks can be accelerated by next-generation mammalian genetics. Mammalian genetics without crossing, where all production and phenotyping studies of genome-edited animals are completed within a single generation drastically reduce the time, space, and effort of conducting the systems research. Next-generation mammalian genetics is based on recent technological advancements in genome editing and developmental engineering. The process begins with introduction of double-strand breaks into genomic DNA by using site-specific endonucleases, which results in highly efficient genome editing in mammalian zygotes or embryonic stem cells. By using nuclease-mediated genome editing in zygotes, or ~100% embryonic stem cell-derived mouse technology, whole-body knock-out and knock-in mice can be produced within a single generation. These emerging technologies allow us to produce multiple knock-out or knock-in strains in high-throughput manner. In this review, we discuss the basic concepts and related technologies as well as current challenges and future opportunities for next-generation mammalian genetics in organism-level systems biology.

Towards Next Generation BI Systems

DEFF Research Database (Denmark)

Varga, Jovan; Romero, Oscar; Pedersen, Torben Bach

2014-01-01

Next generation Business Intelligence (BI) systems require integration of heterogeneous data sources and a strong user-centric orientation. Both needs entail machine-processable metadata to enable automation and allow end users to gain access to relevant data for their decision making processes....... This framework is based on the findings of a survey of current user-centric approaches mainly focusing on query recommendation assistance. Finally, we discuss the benefits of the framework and present the plans for future work....

Data Analysis and Next Generation Assessments

Science.gov (United States)

Pon, Kathy

2013-01-01

For the last decade, much of the work of California school administrators has been shaped by the accountability of the No Child Left Behind Act. Now as they stand at the precipice of Common Core Standards and next generation assessments, it is important to reflect on the proficiency educators have attained in using data to improve instruction and…

Next-Generation Intensity-Duration-Frequency Curves for Hydrologic Design in Snow-Dominated Environments

Energy Technology Data Exchange (ETDEWEB)

Yan, Hongxiang [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Sun, Ning [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Wigmosta, Mark [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Distinguished Faculty Fellow, Department of Civil and Environmental Engineering, University of Washington, Seattle Washington United States; Skaggs, Richard [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Hou, Zhangshuan [Energy and Environment Directorate, Pacific Northwest National Laboratory, Richland Washington United States; Leung, Ruby [Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland Washington United States

2018-02-01

There is a renewed focus on the design of infrastructure resilient to extreme hydrometeorological events. While precipitation-based intensity-duration-frequency (IDF) curves are commonly used as part of infrastructure design, a large percentage of peak runoff events in snow-dominated regions are caused by snowmelt, particularly during rain-on-snow (ROS) events. In these regions, precipitation-based IDF curves may lead to substantial over-/under-estimation of design basis events and subsequent over-/under-design of infrastructure. To overcome this deficiency, we proposed next-generation IDF (NG-IDF) curves, which characterize the actual water reaching the land surface. We compared NG-IDF curves to standard precipitation-based IDF curves for estimates of extreme events at 376 Snowpack Telemetry (SNOTEL) stations across the western United States that each had at least 30 years of high-quality records. We found standard precipitation-based IDF curves at 45% of the stations were subject to under-design, many with significant under-estimation of 100-year extreme events, for which the precipitation-based IDF curves can underestimate water potentially available for runoff by as much as 125% due to snowmelt and ROS events. The regions with the greatest potential for under-design were in the Pacific Northwest, the Sierra Nevada Mountains, and the Middle and Southern Rockies. We also found the potential for over-design at 20% of the stations, primarily in the Middle Rockies and Arizona mountains. These results demonstrate the need to consider snow processes in the development of IDF curves, and they suggest use of the more robust NG-IDF curves for hydrologic design in snow-dominated environments.

Tracing the Baryon Cycle within Nearby Galaxies with a next-generation VLA

Science.gov (United States)

Kepley, Amanda A.; Leroy, Adam; Murphy, Eric J.; ngVLA Baryon Cycle Science Working Group

2017-01-01

The evolution of galaxies over cosmic time is shaped by the cycling of baryons through these systems, namely the inflow of atomic gas, the formation of molecular structures, the birth of stars, and the expulsion of gas due to associated feedback processes. The best way to study this cycle in detail are observations of nearby galaxies. These systems provide a complete picture of baryon cycling over a wide range of astrophysical conditions. In the next decade, higher resolution/sensitivity observations of such galaxies will fundamentally improve our knowledge of galaxy formation and evolution, allowing us to better interpret higher redshift observations of sources that were rapidly evolving at epochs soon after the Big Bang. In particular, the centimeter-to-millimeter part of the spectrum provides critical diagnostics for each of the key baryon cycling processes and access to almost all phases of gas in galaxies: cool and cold gas (via emission and absorption lines), ionized gas (via free-free continuum and recombination lines), cosmic rays and hot gas (via synchrotron emission and the Sunyaev-Zeldovich effect). This poster highlights a number of key science problems in this area whose solutions require a next-generation radio-mm interferometer such as the next-generation VLA.

Next generation breeding.

Science.gov (United States)

Barabaschi, Delfina; Tondelli, Alessandro; Desiderio, Francesca; Volante, Andrea; Vaccino, Patrizia; Valè, Giampiero; Cattivelli, Luigi

2016-01-01

The genomic revolution of the past decade has greatly improved our understanding of the genetic make-up of living organisms. The sequencing of crop genomes has completely changed our vision and interpretation of genome organization and evolution. Re-sequencing allows the identification of an unlimited number of markers as well as the analysis of germplasm allelic diversity based on allele mining approaches. High throughput marker technologies coupled with advanced phenotyping platforms provide new opportunities for discovering marker-trait associations which can sustain genomic-assisted breeding. The availability of genome sequencing information is enabling genome editing (site-specific mutagenesis), to obtain gene sequences desired by breeders. This review illustrates how next generation sequencing-derived information can be used to tailor genomic tools for different breeders' needs to revolutionize crop improvement. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Development of stable Grid service at the next generation system of KEKCC

Science.gov (United States)

Nakamura, T.; Iwai, G.; Matsunaga, H.; Murakami, K.; Sasaki, T.; Suzuki, S.; Takase, W.

2017-10-01

A lot of experiments in the field of accelerator based science are actively running at High Energy Accelerator Research Organization (KEK) by using SuperKEKB and J-PARC accelerator in Japan. In these days at KEK, the computing demand from the various experiments for the data processing, analysis, and MC simulation is monotonically increasing. It is not only for the case with high-energy experiments, the computing requirement from the hadron and neutrino experiments and some projects of astro-particle physics is also rapidly increasing due to the very high precision measurement. Under this situation, several projects, Belle II, T2K, ILC and KAGRA experiments supported by KEK are going to utilize Grid computing infrastructure as the main computing resource. The Grid system and services in KEK, which is already in production, are upgraded for the further stable operation at the same time of whole scale hardware replacement of KEK Central Computer System (KEKCC). The next generation system of KEKCC starts the operation from the beginning of September 2016. The basic Grid services e.g. BDII, VOMS, LFC, CREAM computing element and StoRM storage element are made by the more robust hardware configuration. Since the raw data transfer is one of the most important tasks for the KEKCC, two redundant GridFTP servers are adapted to the StoRM service instances with 40 Gbps network bandwidth on the LHCONE routing. These are dedicated to the Belle II raw data transfer to the other sites apart from the servers for the data transfer usage of the other VOs. Additionally, we prepare the redundant configuration for the database oriented services like LFC and AMGA by using LifeKeeper. The LFC servers are made by two read/write servers and two read-only servers for the Belle II experiment, and all of them have an individual database for the purpose of load balancing. The FTS3 service is newly deployed as a service for the Belle II data distribution. The service of CVMFS stratum-0 is

Software Defined Radio Architecture Contributions to Next Generation Space Communications

Science.gov (United States)

Kacpura, Thomas J.; Eddy, Wesley M.; Smith, Carl R.; Liebetreu, John

2015-01-01

systems, as well as those communications and navigation systems operated by international space agencies and civilian and government agencies. In this paper, we review the philosophies, technologies, architectural attributes, mission services, and communications capabilities that form the structure of candidate next-generation integrated communication architectures for space communications and navigation. A key area that this paper explores is from the development and operation of the software defined radio for the NASA Space Communications and Navigation (SCaN) Testbed currently on the International Space Station (ISS). Evaluating the lessons learned from development and operation feed back into the communications architecture. Leveraging the reconfigurability provides a change in the way that operations are done and must be considered. Quantifying the impact on the NASA Space Telecommunications Radio System (STRS) software defined radio architecture provides feedback to keep the standard useful and up to date. NASA is not the only customer of these radios. Software defined radios are developed for other applications, and taking advantage of these developments promotes an architecture that is cost effective and sustainable. Developments in the following areas such as an updated operating environment, higher data rates, networking and security can be leveraged. The ability to sustain an architecture that uses radios for multiple markets can lower costs and keep new technology infused.

Next-Generation Sequencing: From Understanding Biology to Personalized Medicine

Directory of Open Access Journals (Sweden)

Benjamin Meder

2013-03-01

Full Text Available Within just a few years, the new methods for high-throughput next-generation sequencing have generated completely novel insights into the heritability and pathophysiology of human disease. In this review, we wish to highlight the benefits of the current state-of-the-art sequencing technologies for genetic and epigenetic research. We illustrate how these technologies help to constantly improve our understanding of genetic mechanisms in biological systems and summarize the progress made so far. This can be exemplified by the case of heritable heart muscle diseases, so-called cardiomyopathies. Here, next-generation sequencing is able to identify novel disease genes, and first clinical applications demonstrate the successful translation of this technology into personalized patient care.

Optimal localisation of next generation Biofuel production in Sweden

Energy Technology Data Exchange (ETDEWEB)

Wetterlund, Elisabeth [Linkoeping Univ., Linkoeping (Sweden); Pettersson, Karin [Chalmers Univ. of Technology, Goeteborg (Sweden); Mossberg, Johanna [SP Technical Research Inst. of Sweden, Boraas (Sweden)] [and others

2013-09-01

With a high availability of lignocellulosic biomass and various types of cellulosic by-products, as well as a large number of industries, Sweden is a country of great interest for future large scale production of sustainable, next generation biofuels. This is most likely also a necessity as Sweden has the ambition to be independent of fossil fuels in the transport sector by the year 2030 and completely fossil free by 2050. In order to reach competitive biofuel production costs, plants with large production capacities are likely to be required. Feedstock intake capacities in the range of about 1-2 million tonnes per year, corresponding to a biomass feed of 300-600 MW, can be expected, which may lead to major logistical challenges. To enable expansion of biofuel production in such large plants, as well as provide for associated distribution requirements, it is clear that substantial infrastructure planning will be needed. The geographical location of the production plant facilities is therefore of crucial importance and must be strategic to minimise the transports of raw material as well as of final product. Competition for the available feedstock, from for example forest industries and CHP plants (combined heat and power) further complicates the localisation problem. Since the potential for an increased biomass utilisation is limited, high overall resource efficiency is of great importance. Integration of biofuel production processes in existing industries or in district heating systems may be beneficial from several aspects, such as opportunities for efficient heat integration, feedstock and equipment integration, as well as access to existing experience and know-how. This report describes the development of Be Where Sweden, a geographically explicit optimisation model for localisation of next generation biofuel production plants in Sweden. The main objective of developing such a model is to be able to assess production plant locations that are robust to varying

Next Generation Drivetrain Development and Test Program

Energy Technology Data Exchange (ETDEWEB)

Keller, Jonathan; Erdman, Bill; Blodgett, Doug; Halse, Chris; Grider, Dave

2015-11-03

This presentation was given at the Wind Energy IQ conference in Bremen, Germany, November 30 through December 2, 2105. It focused on the next-generation drivetrain architecture and drivetrain technology development and testing (including gearbox and inverter software and medium-voltage inverter modules.

Implementation of Cloud based next generation sequencing data analysis in a clinical laboratory.

Science.gov (United States)

Onsongo, Getiria; Erdmann, Jesse; Spears, Michael D; Chilton, John; Beckman, Kenneth B; Hauge, Adam; Yohe, Sophia; Schomaker, Matthew; Bower, Matthew; Silverstein, Kevin A T; Thyagarajan, Bharat

2014-05-23

The introduction of next generation sequencing (NGS) has revolutionized molecular diagnostics, though several challenges remain limiting the widespread adoption of NGS testing into clinical practice. One such difficulty includes the development of a robust bioinformatics pipeline that can handle the volume of data generated by high-throughput sequencing in a cost-effective manner. Analysis of sequencing data typically requires a substantial level of computing power that is often cost-prohibitive to most clinical diagnostics laboratories. To address this challenge, our institution has developed a Galaxy-based data analysis pipeline which relies on a web-based, cloud-computing infrastructure to process NGS data and identify genetic variants. It provides additional flexibility, needed to control storage costs, resulting in a pipeline that is cost-effective on a per-sample basis. It does not require the usage of EBS disk to run a sample. We demonstrate the validation and feasibility of implementing this bioinformatics pipeline in a molecular diagnostics laboratory. Four samples were analyzed in duplicate pairs and showed 100% concordance in mutations identified. This pipeline is currently being used in the clinic and all identified pathogenic variants confirmed using Sanger sequencing further validating the software.

An Operations Concept for the Next Generation VLA

Science.gov (United States)

Kepley, Amanda; McKinnon, Mark; Selina, Rob; Murphy, Eric Joseph; ngVLA project

2018-01-01

This poster presents an operations plan for the next generation VLA (ngVLA), which is a proposed 214 element interferometer operating from ~1-115GHz, located in the southwestern United States. The operations requirements for this instrument are driven by the large number of antennas spread out over a multi-state area and a cap on the operations budget of 3 times that of the current VLA. These constraints require that the maintenance is a continuous process and that individual antennas are self-sufficient, making flexible subarrays crucial. The ngVLA will produce science ready data products for its users, building on the pioneering work being currently done at ALMA and the JVLA. Finally, the ngVLA will adopt a user support model similar to those at other large facilities (ALMA, HST, JWST, etc).

Next-generation science information network for leading-edge applications

International Nuclear Information System (INIS)

Urushidani, S.; Matsukata, J.

2008-01-01

High-speed networks are definitely essential tools for leading-edge applications in many research areas, including nuclear fusion research. This paper describes a number of advanced features in the Japanese next-generation science information network, called SINET3, and gives researchers clues on the uses of advanced high-speed network for their applications. The network services have four categories, multiple layer transfer, enriched virtual private network, enhanced quality-of-service, and bandwidth on demand services, and comprise a versatile service platform. The paper also describes the network architecture and advanced networking capabilities that enable economical service accommodation and flexible network resource assignment as well as effective use of Japan's first 40-Gbps lines

Next-generation science information network for leading-edge applications

Energy Technology Data Exchange (ETDEWEB)

Urushidani, S. [National Institute of Informatics, 2-1-2 Hitotsubashi Chiyoda-ku, Tokyo 101-8430 (Japan)], E-mail: urushi@nii.ac.jp; Matsukata, J. [National Institute of Informatics, 2-1-2 Hitotsubashi Chiyoda-ku, Tokyo 101-8430 (Japan)

2008-04-15

High-speed networks are definitely essential tools for leading-edge applications in many research areas, including nuclear fusion research. This paper describes a number of advanced features in the Japanese next-generation science information network, called SINET3, and gives researchers clues on the uses of advanced high-speed network for their applications. The network services have four categories, multiple layer transfer, enriched virtual private network, enhanced quality-of-service, and bandwidth on demand services, and comprise a versatile service platform. The paper also describes the network architecture and advanced networking capabilities that enable economical service accommodation and flexible network resource assignment as well as effective use of Japan's first 40-Gbps lines.

Heterogeneous next-generation wireless network interference model-and its applications

KAUST Repository

Mahmood, Nurul Huda

2014-04-01

Next-generation wireless systems facilitating better utilisation of the scarce radio spectrum have emerged as a response to inefficient and rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing primary systems, yet unwanted interference at the primary receivers is unavoidable. In order to design efficient next-generation systems and to minimise the adverse effect of their interference, it is necessary to realise how the resulting interference impacts the performance of the primary systems. In this work, a generalised framework for the interference analysis of such a next-generation system is presented where the nextgeneration transmitters may transmit randomly with different transmit powers. The analysis is built around a model developed for the statistical representation of the interference at the primary receivers, which is then used to evaluate various performance measures of the primary system. Applications of the derived interference model in designing the next-generation network system parameters are also demonstrated. Such approach provides a unified and generalised framework, the use of which allows a wide range of performance metrics can be evaluated. Findings of the analytical performance analyses are confirmed through extensive computer-based Monte-Carlo simulations. © 2012 John Wiley & Sons, Ltd.

Cyberwar XXI: quantifying the unquantifiable: adaptive AI for next-generation conflict simulations

Science.gov (United States)

Miranda, Joseph; von Kleinsmid, Peter; Zalewski, Tony

2004-08-01

The era of the "Revolution in Military Affairs," "4th Generation Warfare" and "Asymmetric War" requires novel approaches to modeling warfare at the operational and strategic level of modern conflict. For example, "What if, in response to our planned actions, the adversary reacts in such-and-such a manner? What will our response be? What are the possible unintended consequences?" Next generation conflict simulation tools are required to help create and test novel courses of action (COA's) in support of real-world operations. Conflict simulations allow non-lethal and cost-effective exploration of the "what-if" of COA development. The challenge has been to develop an automated decision-support software tool which allows competing COA"s to be compared in simulated dynamic environments. Principal Investigator Joseph Miranda's research is based on modeling an integrated military, economic, social, infrastructure and information (PMESII) environment. The main effort was to develop an adaptive AI engine which models agents operating within an operational-strategic conflict environment. This was implemented in Cyberwar XXI - a simulation which models COA selection in a PMESII environment. Within this framework, agents simulate decision-making processes and provide predictive capability of the potential behavior of Command Entities. The 2003 Iraq is the first scenario ready for V&V testing.

76 FR 49776 - The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop

Science.gov (United States)

2011-08-11

...] The Development and Evaluation of Next-Generation Smallpox Vaccines; Public Workshop AGENCY: Food and... Evaluation of Next-Generation Smallpox Vaccines.'' The purpose of the public workshop is to identify and discuss the key issues related to the development and evaluation of next-generation smallpox vaccines. The...

Applications of nanotechnology, next generation sequencing and microarrays in biomedical research.

Science.gov (United States)

Elingaramil, Sauli; Li, Xiaolong; He, Nongyue

2013-07-01

Next-generation sequencing technologies, microarrays and advances in bio nanotechnology have had an enormous impact on research within a short time frame. This impact appears certain to increase further as many biomedical institutions are now acquiring these prevailing new technologies. Beyond conventional sampling of genome content, wide-ranging applications are rapidly evolving for next-generation sequencing, microarrays and nanotechnology. To date, these technologies have been applied in a variety of contexts, including whole-genome sequencing, targeted re sequencing and discovery of transcription factor binding sites, noncoding RNA expression profiling and molecular diagnostics. This paper thus discusses current applications of nanotechnology, next-generation sequencing technologies and microarrays in biomedical research and highlights the transforming potential these technologies offer.

Next generation surveillance system (NGSS)

International Nuclear Information System (INIS)

Aparo, Massimo

2006-01-01

Development of 'functional requirements' for transparency systems may offer a near-term mode of regional cooperation. New requirements under development at the IAEA may provide a foundation for this potential activity. The Next Generation Surveillance System (NGSS) will become the new IAEA remote monitoring system Under new requirements the NGSS would attempt to use more commercial components to reduce cost, increase radiation survivability and further increase reliability. The NGSS must be available in two years due to rapidly approaching obsolescence in the existing DCM family. (author)

Optimizing the next generation optical access networks

DEFF Research Database (Denmark)

Amaya Fernández, Ferney Orlando; Soto, Ana Cardenas; Tafur Monroy, Idelfonso

2009-01-01

Several issues in the design and optimization of the next generation optical access network (NG-OAN) are presented. The noise, the distortion and the fiber optic nonlinearities are considered to optimize the video distribution link in a passive optical network (PON). A discussion of the effect...

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 3. IPv6: The Next Generation Internet Protocol - IPv4 and its Shortcomings. Harsha Srinath. General Article Volume 8 Issue 3 March 2003 pp 33-41. Fulltext. Click here to view fulltext PDF. Permanent link:

IPv6: The Next Generation Internet Protocol

Indian Academy of Sciences (India)

Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 4. IPv6: The Next Generation Internet Protocol - New Features in IPv6. Harsha Srinath. General Article Volume 8 Issue 4 April 2003 pp 8-16. Fulltext. Click here to view fulltext PDF. Permanent link:

Next-Generation Sequencing for Binary Protein-Protein Interactions

Directory of Open Access Journals (Sweden)

Bernhard eSuter

2015-12-01

Full Text Available The yeast two-hybrid (Y2H system exploits host cell genetics in order to display binary protein-protein interactions (PPIs via defined and selectable phenotypes. Numerous improvements have been made to this method, adapting the screening principle for diverse applications, including drug discovery and the scale-up for proteome wide interaction screens in human and other organisms. Here we discuss a systematic workflow and analysis scheme for screening data generated by Y2H and related assays that includes high-throughput selection procedures, readout of comprehensive results via next-generation sequencing (NGS, and the interpretation of interaction data via quantitative statistics. The novel assays and tools will serve the broader scientific community to harness the power of NGS technology to address PPI networks in health and disease. We discuss examples of how this next-generation platform can be applied to address specific questions in diverse fields of biology and medicine.

AUTOMATIC GENERATION OF ROAD INFRASTRUCTURE IN 3D FOR VEHICLE SIMULATORS

Directory of Open Access Journals (Sweden)

Adam Orlický

2017-12-01

Full Text Available One of the modern methods of testing new systems and interfaces in vehicles is testing in a vehicle simulator. Providing quality models of virtual scenes is one of tasks for driver-car interaction interface simulation. Nowadays, there exist many programs for creating 3D models of road infrastructures, but most of these programs are very expensive or canÂtt export models for the following use. Therefore, a plug-in has been developed at the Faculty of Transportation Sciences in Prague. It can generate road infrastructure by Czech standard for designing roads (CSN 73 6101. The uniqueness of this plug-in is that it is the first tool for generating road infrastructure in NURBS representation. This type of representation brings more exact models and allows to optimize transfer for creating quality models for vehicle simulators. The scenes created by this plug-in were tested on vehicle simulators. The results have shown that with newly created scenes drivers had a much better feeling in comparison to previous scenes.

Next Generation Sequencing of Ancient DNA: Requirements, Strategies and Perspectives

Directory of Open Access Journals (Sweden)

Michael Knapp

2010-07-01

Full Text Available The invention of next-generation-sequencing has revolutionized almost all fields of genetics, but few have profited from it as much as the field of ancient DNA research. From its beginnings as an interesting but rather marginal discipline, ancient DNA research is now on its way into the centre of evolutionary biology. In less than a year from its invention next-generation-sequencing had increased the amount of DNA sequence data available from extinct organisms by several orders of magnitude. Ancient DNA  research is now not only adding a temporal aspect to evolutionary studies and allowing for the observation of evolution in real time, it also provides important data to help understand the origins of our own species. Here we review progress that has been made in next-generation-sequencing of ancient DNA over the past five years and evaluate sequencing strategies and future directions.

NOAA Next Generation Radar (NEXRAD) Level 3 Products

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level 3 weather radar products collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska,...

Fiscal Feasibility Assessment Applied to Transport Infrastructure Projects

Energy Technology Data Exchange (ETDEWEB)

Guilherme de Aragão, J.J.; Santos Fontes Pereira, L. dos; Yamashita, Y.; Brandão, R.

2016-07-01

The demand for transport infrastructure investment is a latent issue for several countries, mainly for developing countries. However, investments in major logistics projects should be carefully evaluated, in order that their deployment induces development without endangering fiscal sustainability by excessive public indebtedness. Fiscal accounting practices used currently in the feasibility studies of transport infrastructures in Brazil are very limited, as they do not consider indirect and induced effects of the infrastructure investment in the fiscal evaluation. In addition, the corresponding influence area has not an established delimitation method. The aim of the present paper is to develop a model for calculating economic and fiscal impacts of transport infrastructure investment projects that includes the direct, indirect and induced effects within a reference area do be determined. First, different project assessment guides in Brazil and abroad are examined with a special focus on the assessment of economic and fiscal impacts of the projects. Based on the assessment experience and on the definition of the fiscal balance of an infrastructure project, the next step sets up a framework for the calculation of the impacts, using more simplified data. (Author)

Diagnostics of Primary Immunodeficiencies through Next Generation Sequencing

Directory of Open Access Journals (Sweden)

Vera Gallo

2016-11-01

Full Text Available Background: Recently, a growing number of novel genetic defects underlying primary immunodeficiencies (PID have been identified, increasing the number of PID up to more than 250 well-defined forms. Next-generation sequencing (NGS technologies and proper filtering strategies greatly contributed to this rapid evolution, providing the possibility to rapidly and simultaneously analyze large numbers of genes or the whole exome. Objective: To evaluate the role of targeted next-generation sequencing and whole exome sequencing in the diagnosis of a case series, characterized by complex or atypical clinical features suggesting a PID, difficult to diagnose using the current diagnostic procedures.Methods: We retrospectively analyzed genetic variants identified through targeted next-generation sequencing or whole exome sequencing in 45 patients with complex PID of unknown etiology. Results: 40 variants were identified using targeted next-generation sequencing, while 5 were identified using whole exome sequencing. Newly identified genetic variants were classified into 4 groups: I variations associated with a well-defined PID; II variations associated with atypical features of a well-defined PID; III functionally relevant variations potentially involved in the immunological features; IV non-diagnostic genotype, in whom the link with phenotype is missing. We reached a conclusive genetic diagnosis in 7/45 patients (~16%. Among them, 4 patients presented with a typical well-defined PID. In the remaining 3 cases, mutations were associated with unexpected clinical features, expanding the phenotypic spectrum of typical PIDs. In addition, we identified 31 variants in 10 patients with complex phenotype, individually not causative per se of the disorder.Conclusion: NGS technologies represent a cost-effective and rapid first-line genetic approaches for the evaluation of complex PIDs. Whole exome sequencing, despite a moderate higher cost compared to targeted, is

The Small Aircraft Transportation System for America: A Case in Public Infrastructure Change

Science.gov (United States)

Bowen, Brent D.

2000-01-01

The National Aeronautics and Space Administration (NASA), U.S. Department of Transportation, Federal Aviation Administration, industry stakeholders, and academia, have joined forces to pursue the NASA National General Aviation Roadmap leading to a Small Aircraft Transportation System (SATS). This strategic undertaking has a 25-year goal to bring next-generation technologies and improve travel between remote communities and transportation centers in urban areas by utilizing the nation's 5,400 public-use general aviation airports. To facilitate this initiative, a comprehensive upgrade of public infrastructure must be planned, coordinated, and implemented within the framework of the national air transportation system. The Nebraska NASA EPSCoR Program has proposed to deliver research support in key public infrastructure areas in coordination with the General Aviation Program Office at the NASA Langley Research Center. Ultimately, SATS may permit tripling aviation system throughput capacity by tapping the underutilized general aviation facilities to achieve the national goal of doorstep-to-destination travel at four times the speed of highways for the nation's suburban, rural, and remote communities.

Examination of concept of next generation computer. Progress report 1999

Energy Technology Data Exchange (ETDEWEB)

Higuchi, Kenji; Hasegawa, Yukihiro; Hirayama, Toshio

2000-12-01

The Center for Promotion of Computational Science and Engineering has conducted R and D works on the technology of parallel processing and has started the examination of the next generation computer in 1999. This report describes the behavior analyses of quantum calculation codes. It also describes the consideration for the analyses and examination results for the method to reduce cash misses. Furthermore, it describes a performance simulator that is being developed to quantitatively examine the concept of the next generation computer. (author)

Preparing for the Next Generation of Direct Broadcast

Science.gov (United States)

Shin, H.; Friedman Dubey, K.; Baptiste, E.; Prasad, K.; Lawrence, D.

2010-12-01

With the anticipated launch of NPP, JPSS-1 and GOES-R in the next five years, the flow of weather data to users will rise ten times (Berchoff, 2009). This volume of data will put a strain on the government infrastructure tasked for data distribution, which could limit real-time data distribution to government users only, forcing others to retrieve their data days to weeks later. In order to receive real-time data, direct reception will become a necessity. SeaSpace Corporation has created a complete solution in anticipation of the forthcoming needs of data users. This solution is made up of four parts: 1) ground reception stations, 2) software to process the data into products, 3) data storage hardware, and 4) data cataloging software and server. The ground station component consists of two systems, an X/L/S-band tracking system and an L-band geostationary system. The combined X-, L-, and S-band reception capabilities are included to ensure the user can receive the maximum amount of data. The X-band receiver in this system can receive data from Terra, Aqua, NPP, JPSS, Oceansat-2, and FY-3. The L-band receiver can currently receive NOAA and MetOp. The follow-on to MetOp will be assigned the mid-morning orbit in the next generation constellation, ensuring L-band reception will continue to be a necessity. The S-band is used for DMSP reception, which may, in the near-future, become more widely available to non-defense clients. The L-band stationary antenna in the proposed solution is used for reception of geostationary satellites, such as GOES, COMS, and MTSAT. Upon launch, GOES-R data can be received with hardware/software upgrade. Once the data is received by the ground stations, TeraScan’s Rapid Environmental Processing System (REPS) automatically processes the data through level 3 products using the official NOAA and NASA algorithms. REPS can process large amounts of satellite data incredibly quickly: for instance, all MODIS products are produced in less than

Next-Generation Pathology.

Science.gov (United States)

Caie, Peter D; Harrison, David J

2016-01-01

The field of pathology is rapidly transforming from a semiquantitative and empirical science toward a big data discipline. Large data sets from across multiple omics fields may now be extracted from a patient's tissue sample. Tissue is, however, complex, heterogeneous, and prone to artifact. A reductionist view of tissue and disease progression, which does not take this complexity into account, may lead to single biomarkers failing in clinical trials. The integration of standardized multi-omics big data and the retention of valuable information on spatial heterogeneity are imperative to model complex disease mechanisms. Mathematical modeling through systems pathology approaches is the ideal medium to distill the significant information from these large, multi-parametric, and hierarchical data sets. Systems pathology may also predict the dynamical response of disease progression or response to therapy regimens from a static tissue sample. Next-generation pathology will incorporate big data with systems medicine in order to personalize clinical practice for both prognostic and predictive patient care.

Potential of OFDM for next generation optical access

Science.gov (United States)

Fritzsche, Daniel; Weis, Erik; Breuer, Dirk

2011-01-01

This paper shows the requirements for next generation optical access (NGOA) networks and analyzes the potential of OFDM (orthogonal frequency division multiplexing) for the use in such network scenarios. First, we show the motivation for NGOA systems based on the future requirements on FTTH access systems and list the advantages of OFDM in such scenarios. In the next part, the basics of OFDM and different methods to generate and detect optical OFDM signals are explained and analyzed. At the transmitter side the options include intensity modulation and the more advanced field modulation of the optical OFDM signal. At the receiver there is the choice between direct detection and coherent detection. As the result of this discussion we show our vision of the future use of OFDM in optical access networks.

Safety criteria for the next generation of European reactors

International Nuclear Information System (INIS)

Dominguez Bautista, M.T.

1995-01-01

For the next generation of reactors, European companies operating in the electricity sector have drawn up a document called European Utilities Requirement (EUR), which sets out the requirements to be met by the designers of future reactors. The main objective of these new requirements is to increase the safety in existing reactors, making good use of operating experience available and the technological developments of the last decade. This paper offers an in-depth analysis of the most significant characteristics, describing how the EUR requirements have been prepared and how they are being implemented by the designers. Areas covered are: - Combining deterministic and probabilistic criteria - Automation of control systems - Design extension for severe accidents - Containment design - Emergency plans - Autonomy versus manual operation

Neutronics activities for next generation devices

International Nuclear Information System (INIS)

Gohar, Y.

1985-01-01

Neutronic activities for the next generation devices are the subject of this paper. The main activities include TFCX and FPD blanket/shield studies, neutronic aspects of ETR/INTOR critical issues, and neutronics computational modules for the tokamak system code and tandem mirror reactor system code. Trade-off analyses, optimization studies, design problem investigations and computational models development for reactor parametric studies carried out for these activities are summarized

A two-stage flow-based intrusion detection model for next-generation networks.

Science.gov (United States)

Umer, Muhammad Fahad; Sher, Muhammad; Bi, Yaxin

2018-01-01

The next-generation network provides state-of-the-art access-independent services over converged mobile and fixed networks. Security in the converged network environment is a major challenge. Traditional packet and protocol-based intrusion detection techniques cannot be used in next-generation networks due to slow throughput, low accuracy and their inability to inspect encrypted payload. An alternative solution for protection of next-generation networks is to use network flow records for detection of malicious activity in the network traffic. The network flow records are independent of access networks and user applications. In this paper, we propose a two-stage flow-based intrusion detection system for next-generation networks. The first stage uses an enhanced unsupervised one-class support vector machine which separates malicious flows from normal network traffic. The second stage uses a self-organizing map which automatically groups malicious flows into different alert clusters. We validated the proposed approach on two flow-based datasets and obtained promising results.

Radio resource management for next generation mobile communication systems

DEFF Research Database (Denmark)

Wang, Hua

The key feature of next generation (4G) mobile communication system is the ability to deliver a variety of multimedia services with different Quality-of-Service (QoS) requirements. Compared to the third generation (3G) mobile communication systems, 4G mobile communication system introduces several...

Energy and luminosity requirements for the next generation of linear colliders

International Nuclear Information System (INIS)

Amaldi, U.

1987-01-01

In order to gain new knowledge ('new physics') from 'next generation' linear colliders energy and luminosity are important variables when considering the design of these new elementary particle probes. The standard model of the electroweak interaction is reviewed and stipulations for postulated Higgs particle, a new neutral Z particle, and a new quark and a neutral lepton searches with next generation colliders are given

Dependable Hydrogen and Industrial Heat Generation from the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

Charles V. Park; Michael W. Patterson; Vincent C. Maio; Piyush Sabharwall

2009-03-01

The Department of Energy is working with industry to develop a next generation, high-temperature gas-cooled nuclear reactor (HTGR) as a part of the effort to supply the US with abundant, clean and secure energy. The Next Generation Nuclear Plant (NGNP) project, led by the Idaho National Laboratory, will demonstrate the ability of the HTGR to generate hydrogen, electricity, and high-quality process heat for a wide range of industrial applications. Substituting HTGR power for traditional fossil fuel resources reduces the cost and supply vulnerability of natural gas and oil, and reduces or eliminates greenhouse gas emissions. As authorized by the Energy Policy Act of 2005, industry leaders are developing designs for the construction of a commercial prototype producing up to 600 MWt of power by 2021. This paper describes a variety of critical applications that are appropriate for the HTGR with an emphasis placed on applications requiring a clean and reliable source of hydrogen. An overview of the NGNP project status and its significant technology development efforts are also presented.

Perspectives on the development of next generation reactor systems safety analysis codes

International Nuclear Information System (INIS)

Zhang, H.

2015-01-01

'Full text:' Existing reactor system analysis codes, such as RELAP5-3D and TRAC, have gained worldwide success in supporting reactor safety analyses, as well as design and licensing of new reactors. These codes are important assets to the nuclear engineering research community, as well as to the nuclear industry. However, most of these codes were originally developed during the 1970s', and it becomes necessary to develop next-generation reactor system analysis codes for several reasons. Firstly, as new reactor designs emerge, there are new challenges emerging in numerical simulations of reactor systems such as long lasting transients and multi-physics phenomena. These new requirements are beyond the range of applicability of the existing system analysis codes. Advanced modeling and numerical methods must be taken into consideration to improve the existing capabilities. Secondly, by developing next-generation reactor system analysis codes, the knowledge (know how) in two phase flow modeling and the highly complex constitutive models will be transferred to the young generation of nuclear engineers. And thirdly, all computer codes have limited shelf life. It becomes less and less cost-effective to maintain a legacy code, due to the fast change of computer hardware and software environment. There are several critical perspectives in terms of developing next-generation reactor system analysis codes: 1) The success of the next-generation codes must be built upon the success of the existing codes. The knowledge of the existing codes, not just simply the manuals and codes, but knowing why and how, must be transferred to the next-generation codes. The next-generation codes should encompass the capability of the existing codes. The shortcomings of existing codes should be identified, understood, and properly categorized, for example into model deficiencies or numerical method deficiencies. 2) State-of-the-art models and numerical methods must be considered to

Perspectives on the development of next generation reactor systems safety analysis codes

Energy Technology Data Exchange (ETDEWEB)

Zhang, H., E-mail: Hongbin.Zhang@inl.gov [Idaho National Laboratory, Idaho Falls, ID (United States)

2015-07-01

'Full text:' Existing reactor system analysis codes, such as RELAP5-3D and TRAC, have gained worldwide success in supporting reactor safety analyses, as well as design and licensing of new reactors. These codes are important assets to the nuclear engineering research community, as well as to the nuclear industry. However, most of these codes were originally developed during the 1970s', and it becomes necessary to develop next-generation reactor system analysis codes for several reasons. Firstly, as new reactor designs emerge, there are new challenges emerging in numerical simulations of reactor systems such as long lasting transients and multi-physics phenomena. These new requirements are beyond the range of applicability of the existing system analysis codes. Advanced modeling and numerical methods must be taken into consideration to improve the existing capabilities. Secondly, by developing next-generation reactor system analysis codes, the knowledge (know how) in two phase flow modeling and the highly complex constitutive models will be transferred to the young generation of nuclear engineers. And thirdly, all computer codes have limited shelf life. It becomes less and less cost-effective to maintain a legacy code, due to the fast change of computer hardware and software environment. There are several critical perspectives in terms of developing next-generation reactor system analysis codes: 1) The success of the next-generation codes must be built upon the success of the existing codes. The knowledge of the existing codes, not just simply the manuals and codes, but knowing why and how, must be transferred to the next-generation codes. The next-generation codes should encompass the capability of the existing codes. The shortcomings of existing codes should be identified, understood, and properly categorized, for example into model deficiencies or numerical method deficiencies. 2) State-of-the-art models and numerical methods must be considered to

Accelerators for Society - TIARA 2012 Test Infrastructure and Accelerator Research Area (in Polish)

CERN Document Server

Romaniuk, R S

2013-01-01

TIARA (Test Infrastructure and Accelerator Research Area - Preparatory Phae) is an European Collaboration of Accelerator Technology, which by running research projects, technical, networks and infrastructural has a duty to integrate the research and technical communities and infrastructures in the global scale of Europe. The Collaboration gathers all research centers with large accelerator infrastructures. Other ones, like universities, are affiliated as associate members. TIARA-PP (preparatory phase) is an European infrastructural project run by this Consortium and realized inside EU-FP7. The paper presents a general overview of TIARA activities, with an introduction containing a portrait of contemporary accelerator technology and a digest of its applications in modern society.

Synchronization System for Next Generation Light Sources

Energy Technology Data Exchange (ETDEWEB)

Zavriyev, Anton [MagiQ Technologies, Inc., Somerville, MA (United States)

2014-03-27

An alternative synchronization technique – one that would allow explicit control of the pulse train including its repetition rate and delay is clearly desired. We propose such a scheme. Our method is based on optical interferometry and permits synchronization of the pulse trains generated by two independent mode-locked lasers. As the next generation x-ray sources will be driven by a clock signal derived from a mode-locked optical source, our technique will provide a way to synchronize x-ray probe with the optical pump pulses.

Risk management of infrastructure development in border area Indonesia - Malaysia

Science.gov (United States)

Fitri, Suryani; Trikariastoto, Reinita, Ita

2017-11-01

Border area is geographically adjacent to neighboring countries with the primary function of maintaining state sovereignty and public welfare. Area in question is part of the provinces, districts or cities that directly intersect with national boundaries (or territory) and / or that have a functional relationship (linkage) and has a strategic value for the state. The border area is considered strategic because it involves the national lives of many people in terms of the interests of political, economic, social and cultural as well as defense and security (poleksosbudhankam) both located on land, sea or air. The border area is geographically adjacent to neighboring countries with the primary function of maintaining state sovereignty and public welfare. Area in question is part of the provinces, districts or cities that directly intersect with national boundaries (or territory) and / or that have a functional relationship (linkage) and has a strategic value for the state. To realize the necessary research on the development of the area, based on good practices from other countries some of the city that can meet all these challenges and at least can be applied with minor changes / adjustments. Furthermore, the application must be supported by the availability of funds. This study to discuss about any problems either obstacles or things that drive to develop function becomes an ideal border area with major support infrastructure for housing, transportation, energy availability, and distribution of clean water which will strengthen in its function which consists of five pillars, namely: central community service; trade and distribution center; financial center; tourism center; related to the field of community development. Articulation between key stakeholders such as government, private, and community is a major concern in this study, including in determining the appropriate financing schemes. The results of this study will be recommended to the government to improve

Mobility Models for Next Generation Wireless Networks Ad Hoc, Vehicular and Mesh Networks

CERN Document Server

Santi, Paolo

2012-01-01

Mobility Models for Next Generation Wireless Networks: Ad Hoc, Vehicular and Mesh Networks provides the reader with an overview of mobility modelling, encompassing both theoretical and practical aspects related to the challenging mobility modelling task. It also: Provides up-to-date coverage of mobility models for next generation wireless networksOffers an in-depth discussion of the most representative mobility models for major next generation wireless network application scenarios, including WLAN/mesh networks, vehicular networks, wireless sensor networks, and

Precision medicine for cancer with next-generation functional diagnostics.

Science.gov (United States)

Friedman, Adam A; Letai, Anthony; Fisher, David E; Flaherty, Keith T

2015-12-01

Precision medicine is about matching the right drugs to the right patients. Although this approach is technology agnostic, in cancer there is a tendency to make precision medicine synonymous with genomics. However, genome-based cancer therapeutic matching is limited by incomplete biological understanding of the relationship between phenotype and cancer genotype. This limitation can be addressed by functional testing of live patient tumour cells exposed to potential therapies. Recently, several 'next-generation' functional diagnostic technologies have been reported, including novel methods for tumour manipulation, molecularly precise assays of tumour responses and device-based in situ approaches; these address the limitations of the older generation of chemosensitivity tests. The promise of these new technologies suggests a future diagnostic strategy that integrates functional testing with next-generation sequencing and immunoprofiling to precisely match combination therapies to individual cancer patients.

Next-generation storm tracking for minimizing service interruption

Energy Technology Data Exchange (ETDEWEB)

Sznaider, R. [Meteorlogix, Minneapolis, MN (United States)

2002-08-01

Several technological changes have taken place in the field of weather radar since its discovery during World War II. A wide variety of industries have benefited over the years from conventional weather radar displays, providing assistance in forecasting and estimating the potential severity of storms. The characteristics of individual storm cells can now be derived from the next-generation of weather radar systems (NEXRAD). The determination of which storm cells possess distinct features such as large hail or developing tornadoes was made possible through the fusing of various pieces of information with radar pictures. To exactly determine when and where a storm will hit, this data can be combined and overlaid into a display that includes the geographical physical landmarks of a specific region. Combining Geographic Information Systems (GIS) and storm tracking provides a more complete, timely and accurate forecast, which clearly benefits the electric utilities industries. The generation and production of energy are dependent on how hot or cold it will be today and tomorrow. The author described each major feature of this next-generation weather radar system. 9 figs.

Educating the next generation of nature entrepreneurs

Science.gov (United States)

Judith C. Jobse; Loes Witteveen; Judith Santegoets; Daan van der Linde

2015-01-01

With this paper, it is illustrated that a focus on entrepreneurship training in the nature and wilderness sector is relevant for diverse organisations and situations. The first curricula on nature entrepreneurship are currently being developed. In this paper the authors describe a project that focusses on educating the next generation of nature entrepreneurs, reflect...

The Next Generation: Students Discuss Archaeology in the 21st Century

OpenAIRE

Sands, Ashley; Butler, Kristin

2010-01-01

The Next Generation Project is a multi-agent, multi-directional cultural diplomacy effort. The need for communication among emerging archaeologists has never been greater. Increasingly, archaeological sites are impacted by military activity, destroyed through the development of dams and building projects, and torn apart through looting. The Next Generation Project works to develop communication via social networking sites online and through in-person meetings at international conferences. As ...

NIRS report of investigations for the development of the next generation PET apparatus. FY 2000

International Nuclear Information System (INIS)

2001-03-01

This is a summary of study reports from representative technology fields for the development of the next generation PET apparatus directing to 3-D images, and is hoped to be useful for future smooth cooperation between the fields. The investigation started from April 2000 in National Institute of Radiological Sciences (NIRS) with cooperation of other facilities, universities and companies. The report involves chapters of: Detector volume and geometrical efficiency- Design criterion for the next generation PET; Scintillator for PET; An investigation of detector and front-end electronics for the next generation PET; A measurement system of depth of interaction; Detector simulator; Development of an evaluation system for PET detector; On the signal processing system for the next generation PET; List-mode data acquisition method for the next generation PET; List-mode data acquisition simulator; Image reconstruction; A Monte Carlo simulator for the next generation PET scanners; Out-of-field of view (FOV) radioactivity; and Published papers and presentations. (N.I.)

The next generation of power reactors - safety characteristics

International Nuclear Information System (INIS)

Modro, S.M.

1995-01-01

The next generation of commercial nuclear power reactors is characterized by a new approach to achieving reliability of their safety systems. In contrast to current generation reactors, these designs apply passive safety features that rely on gravity-driven transfer processes or stored energy, such as gas-pressurized accumulators or electric batteries. This paper discusses the passive safety system of the AP600 and Simplified Boiling Water Reactor (SBWR) designs

Validity of Short and Long Self-Administered Food Frequency Questionnaires in Ranking Dietary Intake in Middle-Aged and Elderly Japanese in the Japan Public Health Center-Based Prospective Study for the Next Generation (JPHC-NEXT) Protocol Area

Science.gov (United States)

Yokoyama, Yuta; Takachi, Ribeka; Ishihara, Junko; Ishii, Yuri; Sasazuki, Shizuka; Sawada, Norie; Shinozawa, Yurie; Tanaka, Junta; Kato, Erika; Kitamura, Kaori; Nakamura, Kazutoshi; Tsugane, Shoichiro

2016-01-01

Background Longitudinal epidemiological studies require both the periodic update of intake information via repeated dietary survey and the minimization of subject burden in responding to questionnaires. We developed a 66-item Food Frequency Questionnaire (short-FFQ) for the Japan Public Health Center-based prospective Study for the Next Generation (JPHC-NEXT) follow-up survey using major foods from the FFQ developed for the original JPHC Study. For the JPHC-NEXT baseline survey, we used a larger 172-item FFQ (long-FFQ), which was also derived from the JPHC-FFQ. We compared the validity of ranking individuals by levels of dietary consumption by these FFQs among residents of selected JPHC-NEXT study areas. Methods From 2012 to 2013, 240 men and women aged 40–74 years from five areas in the JPHC-NEXT protocol were asked to respond to the long-FFQ and provide 12-day weighed food records (WFR) as reference; 228 also completed the short-FFQ. Spearman’s correlation coefficients (CCs) between estimates from the FFQs and WFR were calculated and corrected for intra-individual variation of the WFR. Results Median CC values for energy and 53 nutrients for the short-FFQ for men and women were 0.46 and 0.44, respectively. Respective values for the long-FFQ were 0.50 and 0.43. Compared with the long-FFQ, cross-classification into exact plus adjacent quintiles with the short-FFQ ranged from 68% to 91% in men and 58% to 85% in women. Conclusions Similar to the long-FFQ, the short-FFQ provided reasonably valid measures for ranking middle-aged and elderly Japanese for many nutrients and food groups. The short-FFQ can be used in follow-up surveys in prospective cohort studies aimed at updating diet rank information. PMID:27064130

Next generation solar energy. From fundamentals to applications

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-07-01

Within the International Conference between 12th and 14th December, 2011 in Erlangen (Federal Republic of Germany) the following lectures were presented: (1) The opto-electronic physics required to approach the Shockley-Queisser efficiency limit (E. Yablonovitch); (2) The Shockley-Queisser-limit and beyond (G.H. Bauer); (3) Designing composite nanomaterials for photovoltaic devices (B. Rech); (4) Light-Material interactions in energy conversion (H. Atwater); (5) Functional imaging of hybrid nanostructures - Visualizing mechanisms of solar energy utilization (L. Lauhon); (6) Are photosynthetic proteins suitable for PV applications (Y. Rosenwaks); (7) Detailed balance limit in photovoltaic systems (U. Rau); (8) Plasmonics and nanophotonics for next generation photovoltaics (E. Garnett); (9) Dispersion, wave propagation and efficiency analysis of nanowire solar cells (B. Witzigmann); (10) Application of nanostructures to next generation photovoltaics - Opportunities and challenges from an industrial research perspective (L. Tsakalakos); (11) Triplet states in organic and organometallic photovoltaic cells (K.S. Schanze); (12) New photoelectrode architectures (J.T. Hupp); (13) Dendrimers for optoelectronic and photovoltaic applications (P. Ceroni); (14) Photon management with luminescent materials (J. Goldschmidt); (15) Economical aspects of next generation solar cell technologies (W. Hoffmann); (16) Scalability in solar energy conversion - First-row transition metal-based chromophores for dye-sensitized solar cells (J. McCusker); (17) Designing organic materials for photovoltaic devices (A. Harriman); (18) Molecular photovoltaics - What can we learn from model studies (B. Albinsson); (19) Porphyrin-sensitised titanium dioxide solar cells (D. Officer); (20) Light-harvesting: Charge separation, and charge-transportation properties of novel materials for organic photovoltaics (H. Imahori); (21) Phthalocyanines for molecular photovoltaics (T. Torres); (22) Photophysics of

Report on the international workshop on next generation linear colliders

International Nuclear Information System (INIS)

Ruth, R.D.

1989-05-01

Many laboratories around the world have begun vigorous research programs on a next generation linear collider (NLC). However, it has been recognized that the research towards NLC is beyond the capabilities of any one laboratory presently. This workshop was organized to begin a series of workshops that address this problem. Specifically, the main goals of the workshop were to discuss research programs of the various laboratories around the world, to identify common areas of interest in the various NLC designs, and finally to advance these programs by collaboration. The particular topics discussed briefly in this paper are: parameters, rf power, structures, final focus, beam dynamics, damping rings, and instrumentation. 2 refs., 3 figs., 6 tabs

Next Generation, Si-Compatible Materials and Devices in the Si-Ge-Sn System

Science.gov (United States)

2015-10-09

and conclusions The work initially focused on growth of next generation Ge1-ySny alloys on Ge buffered Si wafers via UHV CVD depositions of Ge3H8...Abstract The work initially focused on growth of next generation Ge1-ySny alloys on Ge buffered Si wafers via UHV CVD depositions of Ge3H8, SnD4. The...AFRL-AFOSR-VA-TR-2016-0044 Next generation, Si -compatible materials and devices in the Si - Ge -Sn system John Kouvetakis ARIZONA STATE UNIVERSITY Final

Next Generation Nuclear Plant GAP Analysis Report

Energy Technology Data Exchange (ETDEWEB)

Ball, Sydney J [ORNL; Burchell, Timothy D [ORNL; Corwin, William R [ORNL; Fisher, Stephen Eugene [ORNL; Forsberg, Charles W. [Massachusetts Institute of Technology (MIT); Morris, Robert Noel [ORNL; Moses, David Lewis [ORNL

2008-12-01

As a follow-up to the phenomena identification and ranking table (PIRT) studies conducted recently by NRC on next generation nuclear plant (NGNP) safety, a study was conducted to identify the significant 'gaps' between what is needed and what is already available to adequately assess NGNP safety characteristics. The PIRT studies focused on identifying important phenomena affecting NGNP plant behavior, while the gap study gives more attention to off-normal behavior, uncertainties, and event probabilities under both normal operation and postulated accident conditions. Hence, this process also involved incorporating more detailed evaluations of accident sequences and risk assessments. This study considers thermal-fluid and neutronic behavior under both normal and postulated accident conditions, fission product transport (FPT), high-temperature metals, and graphite behavior and their effects on safety. In addition, safety issues related to coupling process heat (hydrogen production) systems to the reactor are addressed, given the limited design information currently available. Recommendations for further study, including analytical methods development and experimental needs, are presented as appropriate in each of these areas.

Beyond Human Capital Development: Balanced Safeguards Workforce Metrics and the Next Generation Safeguards Workforce

International Nuclear Information System (INIS)

2014-01-01

Since its establishment in 2008, the Next Generation Safeguards Initiative (NGSI) has achieved a number of objectives under its five pillars: concepts and approaches, policy development and outreach, international nuclear safeguards engagement, technology development, and human capital development (HCD). As a result of these efforts, safeguards has become much more visible as a critical U.S. national security interest across the U.S. Department of Energy (DOE) complex. However, limited budgets have since created challenges in a number of areas. Arguably, one of the more serious challenges involves NGSI's ability to integrate entry-level staff into safeguards projects. Laissez fair management of this issue across the complex can lead to wasteful project implementation and endanger NGSI's long-term sustainability. The authors provide a quantitative analysis of this problem, focusing on the demographics of the current safeguards workforce and compounding pressures to operate cost-effectively, transfer knowledge to the next generation of safeguards professionals, and sustain NGSI safeguards investments.

HLA typing: Conventional techniques v.next-generation sequencing

African Journals Online (AJOL)

The existing techniques have contributed significantly to our current knowledge of allelic diversity. At present, sequence-based typing (SBT) methods, in particular next-generation sequencing. (NGS), provide the highest possible resolution. NGS platforms were initially only used for genomic sequencing, but also showed.

Oak Ridge National Laboratory Next Generation Safeguards Initiative

Energy Technology Data Exchange (ETDEWEB)

Kirk, Bernadette Lugue [ORNL; Eipeldauer, Mary D [ORNL; Whitaker, J Michael [ORNL

2011-12-01

In 2007, the Department of Energy's National Nuclear Security Administration (DOE/NNSA) Office of Nonproliferation and International Security (NA-24) completed a comprehensive review of the current and potential future challenges facing the international safeguards system. The review examined trends and events impacting the mission of international safeguards and the implications of expanding and evolving mission requirements on the legal authorities and institutions that serve as the foundation of the international safeguards system, as well as the technological, financial, and human resources required for effective safeguards implementation. The review's findings and recommendations were summarized in the report, 'International Safeguards: Challenges and Opportunities for the 21st Century (October 2007)'. One of the report's key recommendations was for DOE/NNSA to launch a major new program to revitalize the international safeguards technology and human resource base. In 2007, at the International Atomic Energy Agency's General Conference, then Secretary of Energy Samuel W. Bodman announced the newly created Next Generation Safeguards Initiative (NGSI). NGSI consists of five program elements: (1) Policy development and outreach; (2) Concepts and approaches; (3) Technology and analytical methodologies; (4) Human resource development; and (5) Infrastructure development. The ensuing report addresses the 'Human Resource Development (HRD)' component of NGSI. The goal of the HRD as defined in the NNSA Program Plan (November 2008) is 'to revitalize and expand the international safeguards human capital base by attracting and training a new generation of talent.' One of the major objectives listed in the HRD goal includes education and training, outreach to universities, professional societies, postdoctoral appointments, and summer internships at national laboratories. ORNL is a participant in the NGSI program, together

The next generation CANDU 6

International Nuclear Information System (INIS)

Hopwood, J.M.

1999-01-01

AECL's product line of CANDU 6 and CANDU 9 nuclear power plants are adapted to respond to changing market conditions, experience feedback and technological development by a continuous improvement process of design evolution. The CANDU 6 Nuclear Power Plant design is a successful family of nuclear units, with the first four units entering service in 1983, and the most recent entering service this year. A further four CANDU 6 units are under construction. Starting in 1996, a focused forward-looking development program is under way at AECL to incorporate a series of individual improvements and integrate them into the CANDU 6, leading to the evolutionary development of the next-generation enhanced CANDU 6. The CANDU 6 improvements program includes all aspects of an NPP project, including engineering tools improvements, design for improved constructability, scheduling for faster, more streamlined commissioning, and improved operating performance. This enhanced CANDU 6 product will combine the benefits of design provenness (drawing on the more than 70 reactor-years experience of the seven operating CANDU 6 units), with the advantages of an evolutionary next-generation design. Features of the enhanced CANDU 6 design include: Advanced Human Machine Interface - built around the Advanced CANDU Control Centre; Advanced fuel design - using the newly demonstrated CANFLEX fuel bundle; Improved Efficiency based on improved utilization of waste heat; Streamlined System Design - including simplifications to improve performance and safety system reliability; Advanced Engineering Tools, -- featuring linked electronic databases from 3D CADDS, equipment specification and material management; Advanced Construction Techniques - based on open top equipment installation and the use of small skid mounted modules; Options defined for Passive Heat Sink capability and low-enrichment core optimization. (author)

Bioinformatics for Next Generation Sequencing Data

Directory of Open Access Journals (Sweden)

Alberto Magi

2010-09-01

Full Text Available The emergence of next-generation sequencing (NGS platforms imposes increasing demands on statistical methods and bioinformatic tools for the analysis and the management of the huge amounts of data generated by these technologies. Even at the early stages of their commercial availability, a large number of softwares already exist for analyzing NGS data. These tools can be fit into many general categories including alignment of sequence reads to a reference, base-calling and/or polymorphism detection, de novo assembly from paired or unpaired reads, structural variant detection and genome browsing. This manuscript aims to guide readers in the choice of the available computational tools that can be used to face the several steps of the data analysis workflow.

Application of Next Generation Sequencing on Genetic Testing

DEFF Research Database (Denmark)

Li, Jian

The discovery of genetic factors behind increasing number of human diseases and the growth of education of genetic knowledge to the public make demands for genetic testing increase rapidly. However, traditional genetic testing methods cannot meet all kinds of the requirements. Next generation seq...

HLA typing: Conventional techniques v. next-generation sequencing ...

African Journals Online (AJOL)

Background. The large number of population-specific polymorphisms present in the HLA complex in the South African (SA) population reduces the probability of finding an adequate HLA-matched donor for individuals in need of an unrelated haematopoietic stem cell transplantation (HSCT). Next-generation sequencing ...

NGSS and the Next Generation of Science Teachers

Science.gov (United States)

Bybee, Rodger W.

2014-01-01

This article centers on the "Next Generation Science Standards" (NGSS) and their implications for teacher development, particularly at the undergraduate level. After an introduction to NGSS and the influence of standards in the educational system, the article addresses specific educational shifts--interconnecting science and engineering…

Next-generation sequencing offers new insights into DNA degradation

DEFF Research Database (Denmark)

Overballe-Petersen, Søren; Orlando, Ludovic Antoine Alexandre; Willerslev, Eske

2012-01-01

The processes underlying DNA degradation are central to various disciplines, including cancer research, forensics and archaeology. The sequencing of ancient DNA molecules on next-generation sequencing platforms provides direct measurements of cytosine deamination, depurination and fragmentation...... rates that previously were obtained only from extrapolations of results from in vitro kinetic experiments performed over short timescales. For example, recent next-generation sequencing of ancient DNA reveals purine bases as one of the main targets of postmortem hydrolytic damage, through base...... elimination and strand breakage. It also shows substantially increased rates of DNA base-loss at guanosine. In this review, we argue that the latter results from an electron resonance structure unique to guanosine rather than adenosine having an extra resonance structure over guanosine as previously suggested....

Optimizing Low Speed VoIP Network for Rural Next Generation Network (R-NGN

Directory of Open Access Journals (Sweden)

Yoanes Bandung

2007-11-01

Full Text Available In this research, we propose an optimization method based-on E-Model for designing an efficient low speed VoIP network for Rural Next Generation Network (R-NGN. We are choosing 128 kbps and 256 kbps bandwidth as the typical community link to be used in the designing of R-NGN infrastructure. The method is based on selection of some VoIP network parameters such as voice coder, communication protocol, packet loss level, network utilization and resource allocation. We draw analytic approach for achieving rating value (R of E-model that represent level of quality of service. In this approach, we focus on delay and packet loss calculation to find the rating value. We state the rating value = 70 as minimum level of quality of service for each call, equivalent to 3.6 of Mean Opinion Score (MOS. In our experiments, either G.723.1 5.3 kbps or G.729 is chosen for maximizing the number of VoIP calls, it depends on link utilization and level of packet loss.

Development of digital plant protection system for Korean Next Generation Reactor

International Nuclear Information System (INIS)

Suk-Joon Park

1998-01-01

A Digital Plant Protection System (DPPS) for Korean Next Generation Reactor (KNGR) is being developed using the Programmable Logic Controller (PLC) technology. For the design verification, the development of the DPPS prototype is progressing at this time. The prototype hardware equipment is installed and software coding is started. DPPS software is being coded by strict software V and V activities and function block language that uses simple graphical symbols. By adopting the PLC technology, the design of DPPS is possible to take full advantages in areas such as automatic testing, simplified calibration, improved isolation between redundant channels, reduced internal and external wiring and increased plant availability. (author)

Graphene Transparent Conductive Electrodes for Next- Generation Microshutter Arrays

Science.gov (United States)

Li, Mary; Sultana, Mahmooda; Hess, Larry

2012-01-01

Graphene is a single atomic layer of graphite. It is optically transparent and has high electron mobility, and thus has great potential to make transparent conductive electrodes. This invention contributes towards the development of graphene transparent conductive electrodes for next-generation microshutter arrays. The original design for the electrodes of the next generation of microshutters uses indium-tin-oxide (ITO) as the electrode material. ITO is widely used in NASA flight missions. The optical transparency of ITO is limited, and the material is brittle. Also, ITO has been getting more expensive in recent years. The objective of the invention is to develop a graphene transparent conductive electrode that will replace ITO. An exfoliation procedure was developed to make graphene out of graphite crystals. In addition, large areas of single-layer graphene were produced using low-pressure chemical vapor deposition (LPCVD) with high optical transparency. A special graphene transport procedure was developed for transferring graphene from copper substrates to arbitrary substrates. The concept is to grow large-size graphene sheets using the LPCVD system through chemical reaction, transfer the graphene film to a substrate, dope graphene to reduce the sheet resistance, and pattern the film to the dimension of the electrodes in the microshutter array. Graphene transparent conductive electrodes are expected to have a transparency of 97.7%. This covers the electromagnetic spectrum from UV to IR. In comparison, ITO electrodes currently used in microshutter arrays have 85% transparency in mid-IR, and suffer from dramatic transparency drop at a wavelength of near-IR or shorter. Thus, graphene also has potential application as transparent conductive electrodes for Schottky photodiodes in the UV region.

Building a New Generation of Learning: Conversations to Catalyze Our Construction

Science.gov (United States)

Milliron, Mark David; Plinske, Kathleen; Noonan-Terry, Coral

2008-01-01

Rather than focus primarily on the next generation of learners, the authors argue we are best served to focus on building out our on-ground and online infrastructures for a new generation of learning--blending multiple learning modes, technologies, and techniques over the course of the next 15-20 years to serve the diverse array of students from…

NOAA Next Generation Radar (NEXRAD) Level 2 Base Data

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This dataset consists of Level II weather radar data collected from Next-Generation Radar (NEXRAD) stations located in the contiguous United States, Alaska, Hawaii,...

Cloud Sourcing – Next Generation Outsourcing?

OpenAIRE

Muhic, Mirella; Johansson, Björn

2014-01-01

Although Cloud Sourcing has been around for some time it could be questioned what actually is known about it. This paper presents a literature review on the specific question if Cloud Sourcing could be seen as the next generation of outsourcing. The reason for doing this is that from an initial sourcing study we found that the sourcing decisions seems to go in the direction of outsourcing as a service which could be described as Cloud Sourcing. Whereas some are convinced that Cloud Sourcing r...

Shield design for next-generation, low-neutron-fluence, superconducting tokamaks

International Nuclear Information System (INIS)

Lee, V.D.; Gohar, Y.

1985-01-01

A shield design using stainless steel (SST), water, boron carbide, lead, and concrete materials was developed for the next-generation tokamak device with superconducting toroidal field (TF) coils and low neutron fluence. A device such as the Tokamak Fusion Core Experiment (TFCX) is representative of the tokamak design which could use this shield design. The unique feature of this reference design is that a majority of the bulk steel in the shield is in the form of spherical balls with two small, flat spots. The balls are purchased from ball-bearing manufacturers and are added as bulk shielding to the void areas of builtup, structural steel shells which form the torus cavity of the plasma chamber. This paper describes the design configuration of the shielding components

Shield design for next-generation, low-neutron-fluence, superconducting tokamaks

International Nuclear Information System (INIS)

Lee, V.D.; Gohar, Y.

1985-01-01

A shield design using stainless steel (SST), water, boron carbide, lead, and concrete materials was developed for the next-generation tokamak device with superconducting toroidal field (TF) coils and low neutron fluence. A device such as the Tokamak Fusion Core Experiment (TFCX) is representative of the tokamak design which could use this shield design. The unique feature of this reference design is that a majority of the bulk steel in the shield is in the form of spherical balls with two small, flat spots. The balls are purchased from ball-bearing manufacturers and are added as bulk shielding to the void areas of built-up, structural steel shells which form the torus cavity of the plasma chamber. This paper describes the design configuration of the shielding components

Trajectory Assessment and Modification Tools for Next Generation Air Traffic Management Operations

Science.gov (United States)

Brasil, Connie; Lee, Paul; Mainini, Matthew; Lee, Homola; Lee, Hwasoo; Prevot, Thomas; Smith, Nancy

2011-01-01

This paper reviews three Next Generation Air Transportation System (NextGen) based high fidelity air traffic control human-in-the-loop (HITL) simulations, with a focus on the expected requirement of enhanced automated trajectory assessment and modification tools to support future air traffic flow management (ATFM) planning positions. The simulations were conducted at the National Aeronautics and Space Administration (NASA) Ames Research Centers Airspace Operations Laboratory (AOL) in 2009 and 2010. The test airspace for all three simulations assumed the mid-term NextGenEn-Route high altitude environment utilizing high altitude sectors from the Kansas City and Memphis Air Route Traffic Control Centers. Trajectory assessment, modification and coordination decision support tools were developed at the AOL in order to perform future ATFM tasks. Overall tool usage results and user acceptability ratings were collected across three areas of NextGen operatoins to evaluate the tools. In addition to the usefulness and usability feedback, feasibility issues, benefits, and future requirements were also addressed. Overall, the tool sets were rated very useful and usable, and many elements of the tools received high scores and were used frequently and successfully. Tool utilization results in all three HITLs showed both user and system benefits including better airspace throughput, reduced controller workload, and highly effective communication protocols in both full Data Comm and mixed-equipage environments.

Securing Networks from Modern Threats using Next Generation Firewalls

OpenAIRE

Delgiusto, Valter

2016-01-01

Classic firewalls have long been unable to cope with modern threats that ordinary Internet users are exposed to. This thesis discusses their successors - the next-generation firewalls. The first part of the thesis describes modern threats and attacks. We described in detail the DoS and APT attacks, which are among the most frequent and which may cause most damage to the system under attack. Then we explained the theoretical basics of firewalls and described the functionalities of next gen...

Next generation of energy production systems

International Nuclear Information System (INIS)

Rouault, J.; Garnier, J.C.; Carre, F.

2003-01-01

This document gathers the slides that have been presented at the Gedepeon conference. Gedepeon is a research group involving scientists from Cea (French atomic energy commission), CNRS (national center of scientific research), EDF (electricity of France) and Framatome that is devoted to the study of new energy sources and particularly to the study of the future generations of nuclear systems. The contributions have been classed into 9 topics: 1) gas cooled reactors, 2) molten salt reactors (MSBR), 3) the recycling of plutonium and americium, 4) reprocessing of molten salt reactor fuels, 5) behavior of graphite under radiation, 6) metallic materials for molten salt reactors, 7) refractory fuels of gas cooled reactors, 8) the nuclear cycle for the next generations of nuclear systems, and 9) organization of research programs on the new energy sources

Next-Generation Multifunctional Electrochromic Devices.

Science.gov (United States)

Cai, Guofa; Wang, Jiangxin; Lee, Pooi See

2016-08-16

during the daytime. Energy can also be stored in the smart windows during the daytime simultaneously and be discharged for use in the evening. These results reveal that the electrochromic devices have potential applications in a wide range of areas. We hope that this Account will promote further efforts toward fundamental research on electrochromic materials and the development of new multifunctional electrochromic devices to meet the growing demands for next-generation electronic systems.

Next generation HOM-damping

Science.gov (United States)

Marhauser, Frank

2017-06-01

Research and development for superconducting radio-frequency cavities has made enormous progress over the last decades from the understanding of theoretical limitations to the industrial mass fabrication of cavities for large-scale particle accelerators. Key technologies remain hot topics due to continuously growing demands on cavity performance, particularly when in pursuit of high quality beams at higher beam currents or higher luminosities than currently achievable. This relates to higher order mode (HOM) damping requirements. Meeting the desired beam properties implies avoiding coupled multi-bunch or beam break-up instabilities depending on the machine and beam parameters that will set the acceptable cavity impedance thresholds. The use of cavity HOM-dampers is crucial to absorb the wakefields, comprised by all beam-induced cavity Eigenmodes, to beam-dynamically safe levels and to reduce the heat load at cryogenic temperature. Cavity damping concepts may vary, but are principally based on coaxial and waveguide couplers as well as beam line absorbers or any combination. Next generation energy recovery linacs and circular colliders call for cavities with strong HOM-damping that can exceed the state-of-the-art, while the operating mode efficiency shall not be significantly compromised concurrently. This imposes major challenges given the rather limited damping concepts. A detailed survey of established cavities is provided scrutinizing the achieved damping performance, shortcomings, and potential improvements. The scaling of the highest passband mode impedances is numerically evaluated in dependence on the number of cells for a single-cell up to a nine-cell cavity, which reveals the increased probability of trapped modes. This is followed by simulations for single-cell and five-cell cavities, which incorporate multiple damping schemes to assess the most efficient concepts. The usage and viability of on-cell dampers is elucidated for the single-cell cavity since it

Preparing the Next Generation of Educators for Democracy

Science.gov (United States)

Embry-Jenlink, Karen

2018-01-01

In the keynote address of the 42nd annual meeting of the Southeastern Regional Educators Association (SRATE), ATE President Karen Embry-Jenlink examines the critical role of teacher educators in preparing the next generation of citizens and leaders to sustain democracy. Drawing from historic and current events and personal experience,…

Next Generation Science Standards: All Standards, All Students

Science.gov (United States)

Lee, Okhee; Miller, Emily C.; Januszyk, Rita

2014-01-01

The Next Generation Science Standards (NGSS) offer a vision of science teaching and learning that presents both learning opportunities and demands for all students, particularly student groups that have traditionally been underserved in science classrooms. The NGSS have addressed issues of diversity and equity from their inception, and the NGSS…

An Infrastructure for UML-Based Code Generation Tools

Science.gov (United States)

Wehrmeister, Marco A.; Freitas, Edison P.; Pereira, Carlos E.

The use of Model-Driven Engineering (MDE) techniques in the domain of distributed embedded real-time systems are gain importance in order to cope with the increasing design complexity of such systems. This paper discusses an infrastructure created to build GenERTiCA, a flexible tool that supports a MDE approach, which uses aspect-oriented concepts to handle non-functional requirements from embedded and real-time systems domain. GenERTiCA generates source code from UML models, and also performs weaving of aspects, which have been specified within the UML model. Additionally, this paper discusses the Distributed Embedded Real-Time Compact Specification (DERCS), a PIM created to support UML-based code generation tools. Some heuristics to transform UML models into DERCS, which have been implemented in GenERTiCA, are also discussed.

Preliminary thoughts on the data acquisition for the next generation of silicon tracking systems

International Nuclear Information System (INIS)

Genat, J.F.; Savoy-Navarro, A.

2007-01-01

Preliminary thoughts about the data acquisition system to be developed for the next generation of large area silicon tracker are presented in this paper. This paper describes the set of data delivered by these tracking systems, and the various stages of processing and data flow transmission from the front-end chip sitting on the detector to the latest stage in the data processing. How to best profit from the status of the art technologies is a major goal. (author)

Next generation advanced nuclear reactor designs

International Nuclear Information System (INIS)

Turgut, M. H.

2009-01-01

Growing energy demand by technological developments and the increase of the world population and gradually diminishing energy resources made nuclear power an indispensable option. The renewable energy sources like solar, wind and geothermal may be suited to meet some local needs. Environment friendly nuclear energy which is a suitable solution to large scale demands tends to develop highly economical, advanced next generation reactors by incorporating technological developments and years of operating experience. The enhancement of safety and reliability, facilitation of maintainability, impeccable compatibility with the environment are the goals of the new generation reactors. The protection of the investment and property is considered as well as the protection of the environment and mankind. They became economically attractive compared to fossil-fired units by the use of standard designs, replacing some active systems by passive, reducing construction time and increasing the operation lifetime. The evolutionary designs were introduced at first by ameliorating the conventional plants, than revolutionary systems which are denoted as generation IV were verged to meet future needs. The investigations on the advanced, proliferation resistant fuel cycle technologies were initiated to minimize the radioactive waste burden by using new generation fast reactors and ADS transmuters.

Four Corners project experience - Applications to next generation FGD

International Nuclear Information System (INIS)

Wild, R.L.; Grimes, R.L.; Wiggins, D.S.

1990-01-01

In June 1984, Arizona Public Service Company started up the flue gas desulfurization system installed on Units 4 and 5 at the Four Corners Power Station. At the time, this represented the largest emissions control retrofit in the industry, and consisted of two 800 MWe units. These units burn a low sulfur subbituminous coal from the adjacent Navajo mine. The FGD system was designed for 72% overall removal, with partial bypass. The SO 2 absorbers were designed for 90% removal. This FGD system is considered to be a second generation design. At the time, it represented state-of-the-art of FGD technology, in terms of both process considerations and materials of construction. In the six years since startup, several modifications have been made in the areas of process chemistry, equipment configuration, and materials of construction. These modifications are applicable to the next generation of FGD systems which will be designed in response to Acid Rain Legislation. This paper presents the original plant design basis, summarizes the operating experience to date, and identifies the modifications and improvements which have been made since startup. In addition, recommendations for new installations are offered

Next-Generation Sequencing in the Mycology Lab.

Science.gov (United States)

Zoll, Jan; Snelders, Eveline; Verweij, Paul E; Melchers, Willem J G

New state-of-the-art techniques in sequencing offer valuable tools in both detection of mycobiota and in understanding of the molecular mechanisms of resistance against antifungal compounds and virulence. Introduction of new sequencing platform with enhanced capacity and a reduction in costs for sequence analysis provides a potential powerful tool in mycological diagnosis and research. In this review, we summarize the applications of next-generation sequencing techniques in mycology.

Fiber to the home: next generation network

Science.gov (United States)

Yang, Chengxin; Guo, Baoping

2006-07-01

Next generation networks capable of carrying converged telephone, television (TV), very high-speed internet, and very high-speed bi-directional data services (like video-on-demand (VOD), Game etc.) strategy for Fiber To The Home (FTTH) is presented. The potential market is analyzed. The barriers and some proper strategy are also discussed. Several technical problems like various powering methods, optical fiber cables, and different network architecture are discussed too.

Next generation multi-particle event generators for the MSSM

International Nuclear Information System (INIS)

Reuter, J.; Kilian, W.; Hagiwara, K.; Krauss, F.; Schumann, S.; Rainwater, D.

2005-12-01

We present a next generation of multi-particle Monte Carlo (MC) Event generators for LHC and ILC for the MSSM, namely the three program packages Madgraph/MadEvent, WHiZard/O'Mega and Sherpa/Amegic++. The interesting but difficult phenomenology of supersymmetric models at the upcoming colliders demands a corresponding complexity and maturity from simulation tools. This includes multi-particle final states, reducible and irreducible backgrounds, spin correlations, real emission of photons and gluons, etc., which are incorporated in the programs presented here. The framework of a model with such a huge particle content and as complicated as the MSSM makes strenuous tests and comparison of codes inevitable. Various tests show agreement among the three different programs; the tables of cross sections produced in these tests may serve as a future reference for other codes. Furthermore, first MSSM physics analyses performed with these programs are presented here. (orig.)

Next-Generation Thermal Infrared Multi-Body Radiometer Experiment (TIMBRE)

Science.gov (United States)

Kenyon, M.; Mariani, G.; Johnson, B.; Brageot, E.; Hayne, P.

2016-10-01

We have developed an instrument concept called TIMBRE which belongs to the important class of instruments called thermal imaging radiometers (TIRs). TIMBRE is the next-generation TIR with unparalleled performance compared to the state-of-the-art.

Evaluation of Green Infrastructure on Peak Flow Mitigation Focusing on the Connectivity of Impervious Areas

Science.gov (United States)

Seo, Y.; Hwang, J.; Kwon, Y.

2017-12-01

The existence of impervious areas is one of the most distinguishing characteristics of urban catchments. It decreases infiltration and increases direct runoff in urban catchments. The recent introduction of green infrastructure in urban catchments for the purpose of sustainable development contributes to the decrease of the directly connected impervious areas (DCIA) by isolating existing impervious areas and consequently, to the flood risk mitigation. This study coupled the width function-based instantaneous hydrograph (WFIUH), which is able to handle the spatial distribution of the impervious areas, with the concept of the DCIA to assess the impact of decreasing DCIA on the shape of direct runoff hydrographs. Using several scenarios for typical green infrastructure and corresponding changes of DCIA in a test catchment, this study evaluated the effect of green infrastructure on the shape of the resulting direct runoff hydrographs and peak flows. The results showed that the changes in the DCIA immediately affects the shape of the direct runoff hydrograph and decreases peak flows depending on spatial implementation scenarios. The quantitative assessment of the spatial distribution of impervious areas and also the changes to the DCIA suggests effective and well-planned green infrastructure can be introduced in urban environments for flood risk management.

What can next generation sequencing do for you? Next generation sequencing as a valuable tool in plant research

OpenAIRE

Bräutigam, Andrea; Gowik, Udo

2010-01-01

Next generation sequencing (NGS) technologies have opened fascinating opportunities for the analysis of plants with and without a sequenced genome on a genomic scale. During the last few years, NGS methods have become widely available and cost effective. They can be applied to a wide variety of biological questions, from the sequencing of complete eukaryotic genomes and transcriptomes, to the genome-scale analysis of DNA-protein interactions. In this review, we focus on the use of NGS for pla...

Targeted enrichment strategies for next-generation plant biology

Science.gov (United States)

Richard Cronn; Brian J. Knaus; Aaron Liston; Peter J. Maughan; Matthew Parks; John V. Syring; Joshua. Udall

2012-01-01

The dramatic advances offered by modem DNA sequencers continue to redefine the limits of what can be accomplished in comparative plant biology. Even with recent achievements, however, plant genomes present obstacles that can make it difficult to execute large-scale population and phylogenetic studies on next-generation sequencing platforms. Factors like large genome...

Next Generation Science Standards: Adoption and Implementation Workbook

Science.gov (United States)

Peltzman, Alissa; Rodriguez, Nick

2013-01-01

The Next Generation Science Standards (NGSS) represent the culmination of years of collaboration and effort by states, science educators and experts from across the United States. Based on the National Research Council's "A Framework for K-12 Science Education" and developed in partnership with 26 lead states, the NGSS, when…

Framework for Leading Next Generation Science Standards Implementation

Science.gov (United States)

Stiles, Katherine; Mundry, Susan; DiRanna, Kathy

2017-01-01

In response to the need to develop leaders to guide the implementation of the Next Generation Science Standards (NGSS), the Carnegie Corporation of New York provided funding to WestEd to develop a framework that defines the leadership knowledge and actions needed to effectively implement the NGSS. The development of the framework entailed…

Next-generation batteries and fuel cells for commercial, military, and space applications

CERN Document Server

Jha, A R

2012-01-01

Distilling complex theoretical physical concepts into an understandable technical framework, Next-Generation Batteries and Fuel Cells for Commercial, Military, and Space Applications describes primary and secondary (rechargeable) batteries for various commercial, military, spacecraft, and satellite applications for covert communications, surveillance, and reconnaissance missions. It emphasizes the cost, reliability, longevity, and safety of the next generation of high-capacity batteries for applications where high energy density, minimum weight and size, and reliability in harsh conditions are

Development of digital plant protection system for Korean Next Generation Reactor

Energy Technology Data Exchange (ETDEWEB)

Park, Suk-Joon [NSSS Engineering and Development Division, Korea Power Engineering Company, Taejon (Korea, Republic of)

1998-10-01

A Digital Plant Protection System (DPPS) for Korean Next Generation Reactor (KNGR) is being developed using the Programmable Logic Controller (PLC) technology. For the design verification, the development of the DPPS prototype is progressing at this time. The prototype hardware equipment is installed and software coding is started. DPPS software is being coded by strict software V and V activities and function block language that uses simple graphical symbols. By adopting the PLC technology, the design of DPPS is possible to take full advantages in areas such as automatic testing, simplified calibration, improved isolation between redundant channels, reduced internal and external wiring and increased plant availability. (author) 8 refs, 4 figs, 3 tabs

Road infrastructure and mobility of consumption in the Mexicali-Imperial Valley border area

Directory of Open Access Journals (Sweden)

Alejandro Mungaray-Moctezuma

2015-06-01

Full Text Available The objective of this study is to analyze the mobility of consumption in the Mexicali-Imperial Valley border area. The study shows that the population in the Mexicali sections closer to border crossings generates the greatest amount of consumption dynamics with places located in Imperial Valley. Conversely, Imperial Valley sections that are more distant from the border concentrate a greater number of destination sites for these cross-border trips. It is concluded that a higher quality and more integrated road infrastructure allows the new consumption centers in Imperial Valley to be located farther away from the border and that the Mexicali population with visas can cross indiscriminately through any border crossing by taking longer journeys toward these centers.

Efficient Cryptography for the Next Generation Secure Cloud

Science.gov (United States)

Kupcu, Alptekin

2010-01-01

Peer-to-peer (P2P) systems, and client-server type storage and computation outsourcing constitute some of the major applications that the next generation cloud schemes will address. Since these applications are just emerging, it is the perfect time to design them with security and privacy in mind. Furthermore, considering the high-churn…

Use of virtual environments to reduce the construction costs of the next generation nuclear power reactors

International Nuclear Information System (INIS)

Whisker, V.E.; Baratta, A.J.

2007-01-01

The near term deployment of the next generation of reactors will only be successful if they are built on time and without the costly overruns experienced in the previous generation. One critical factor in achieving these goals is to ensure the design is optimized for constructability. In this work the authors explored the effectiveness of full-scale virtual reality simulation in the optimization of the design and construction of the next generation of nuclear reactors. The research tested the suitability of immersive virtual reality display technology in aiding engineers in evaluating potential cost reductions that can be realized by the optimization of design and installation and construction sequences. The intent of this research is to see if this type of technology can be used in capacities similar to those currently filled by full-scale physical mockups and desktop simulations. Using a fully-immersive five sided virtual reality system, known as a CAVE, the authors constructed a series of virtual mockups that represented two next generation nuclear power plants, the Westinghouse AP-1000 and the Pebble Bed Modular Reactor (PBMR). These virtual mockups were then tested as a design tool to help locate and correct problem areas, to optimize the construction sequence, and to assist with familiarizing trades people with the performance of maintenance activities. A series of experiments were performed to assess the usefulness of these virtual mockups in accomplishing these tasks. (authors)

The NHERI RAPID Facility: Enabling the Next-Generation of Natural Hazards Reconnaissance

Science.gov (United States)

Wartman, J.; Berman, J.; Olsen, M. J.; Irish, J. L.; Miles, S.; Gurley, K.; Lowes, L.; Bostrom, A.

2017-12-01

The NHERI post-disaster, rapid response research (or "RAPID") facility, headquartered at the University of Washington (UW), is a collaboration between UW, Oregon State University, Virginia Tech, and the University of Florida. The RAPID facility will enable natural hazard researchers to conduct next-generation quick response research through reliable acquisition and community sharing of high-quality, post-disaster data sets that will enable characterization of civil infrastructure performance under natural hazard loads, evaluation of the effectiveness of current and previous design methodologies, understanding of socio-economic dynamics, calibration of computational models used to predict civil infrastructure component and system response, and development of solutions for resilient communities. The facility will provide investigators with the hardware, software and support services needed to collect, process and assess perishable interdisciplinary data following extreme natural hazard events. Support to the natural hazards research community will be provided through training and educational activities, field deployment services, and by promoting public engagement with science and engineering. Specifically, the RAPID facility is undertaking the following strategic activities: (1) acquiring, maintaining, and operating state-of-the-art data collection equipment; (2) developing and supporting mobile applications to support interdisciplinary field reconnaissance; (3) providing advisory services and basic logistics support for research missions; (4) facilitating the systematic archiving, processing and visualization of acquired data in DesignSafe-CI; (5) training a broad user base through workshops and other activities; and (6) engaging the public through citizen science, as well as through community outreach and education. The facility commenced operations in September 2016 and will begin field deployments beginning in September 2018. This poster will provide an overview

Statistical Approaches for Next-Generation Sequencing Data

OpenAIRE

Qiao, Dandi

2012-01-01

During the last two decades, genotyping technology has advanced rapidly, which enabled the tremendous success of genome-wide association studies (GWAS) in the search of disease susceptibility loci (DSLs). However, only a small fraction of the overall predicted heritability can be explained by the DSLs discovered. One possible explanation for this ”missing heritability” phenomenon is that many causal variants are rare. The recent development of high-throughput next-generation sequencing (NGS) ...

Architectural and Algorithmic Requirements for a Next-Generation System Analysis Code

Energy Technology Data Exchange (ETDEWEB)

V.A. Mousseau

2010-05-01

This document presents high-level architectural and system requirements for a next-generation system analysis code (NGSAC) to support reactor safety decision-making by plant operators and others, especially in the context of light water reactor plant life extension. The capabilities of NGSAC will be different from those of current-generation codes, not only because computers have evolved significantly in the generations since the current paradigm was first implemented, but because the decision-making processes that need the support of next-generation codes are very different from the decision-making processes that drove the licensing and design of the current fleet of commercial nuclear power reactors. The implications of these newer decision-making processes for NGSAC requirements are discussed, and resulting top-level goals for the NGSAC are formulated. From these goals, the general architectural and system requirements for the NGSAC are derived.

ERP II: Next-generation Extended Enterprise Resource Planning

DEFF Research Database (Denmark)

Møller, Charles

2004-01-01

ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture.....

ERP II - Next-generation Extended Enterprise Resource Planning

DEFF Research Database (Denmark)

Møller, Charles

2003-01-01

ERP II (ERP/2) systems is a new concept introduced by Gartner Group in 2000 in order to label the latest extensions of the ERP-systems. The purpose of this paper is to explore the next-generation of ERP systems, the Extended Enterprise Resource Planning (EERP or as we prefer to use: e...... impact on extended enterprise architecture....

Next Generation Geothermal Power Plants

Energy Technology Data Exchange (ETDEWEB)

Brugman, John; Hattar, Mai; Nichols, Kenneth; Esaki, Yuri

1995-09-01

A number of current and prospective power plant concepts were investigated to evaluate their potential to serve as the basis of the next generation geothermal power plant (NGGPP). The NGGPP has been envisaged as a power plant that would be more cost competitive (than current geothermal power plants) with fossil fuel power plants, would efficiently use resources and mitigate the risk of reservoir under-performance, and minimize or eliminate emission of pollutants and consumption of surface and ground water. Power plant concepts were analyzed using resource characteristics at ten different geothermal sites located in the western United States. Concepts were developed into viable power plant processes, capital costs were estimated and levelized busbar costs determined. Thus, the study results should be considered as useful indicators of the commercial viability of the various power plants concepts that were investigated. Broadly, the different power plant concepts that were analyzed in this study fall into the following categories: commercial binary and flash plants, advanced binary plants, advanced flash plants, flash/binary hybrid plants, and fossil/geothed hybrid plants. Commercial binary plants were evaluated using commercial isobutane as a working fluid; both air-cooling and water-cooling were considered. Advanced binary concepts included cycles using synchronous turbine-generators, cycles with metastable expansion, and cycles utilizing mixtures as working fluids. Dual flash steam plants were used as the model for the commercial flash cycle. The following advanced flash concepts were examined: dual flash with rotary separator turbine, dual flash with steam reheater, dual flash with hot water turbine, and subatmospheric flash. Both dual flash and binary cycles were combined with other cycles to develop a number of hybrid cycles: dual flash binary bottoming cycle, dual flash backpressure turbine binary cycle, dual flash gas turbine cycle, and binary gas turbine

Environmental Information for the U.S. Next Generation Air Transportation System (NextGen)

Science.gov (United States)

Murray, J.; Miner, C.; Pace, D.; Minnis, P.; Mecikalski, J.; Feltz, W.; Johnson, D.; Iskendarian, H.; Haynes, J.

2009-09-01

It is estimated that weather is responsible for approximately 70% of all air traffic delays and cancellations in the United States. Annually, this produces an overall economic loss of nearly 40B. The FAA and NASA have determined that weather impacts and other environmental constraints on the U.S. National Airspace System (NAS) will increase to the point of system unsustainability unless the NAS is radically transformed. A Next Generation Air Transportation System (NextGen) is planned to accommodate the anticipated demand for increased system capacity and the super-density operations that this transformation will entail. The heart of the environmental information component that is being developed for NextGen will be a 4-dimensional data cube which will include a single authoritative source comprising probabilistic weather information for NextGen Air Traffic Management (ATM) systems. Aviation weather constraints and safety hazards typically comprise meso-scale, storm-scale and microscale observables that can significantly impact both terminal and enroute aviation operations. With these operational impacts in mind, functional and performance requirements for the NextGen weather system were established which require significant improvements in observation and forecasting capabilities. This will include satellite observations from geostationary and/or polar-orbiting hyperspectral sounders, multi-spectral imagers, lightning mappers, space weather monitors and other environmental observing systems. It will also require improved in situ and remotely sensed observations from ground-based and airborne systems. These observations will be used to better understand and to develop forecasting applications for convective weather, in-flight icing, turbulence, ceilings and visibility, volcanic ash, space weather and the environmental impacts of aviation. Cutting-edge collaborative research efforts and results from NASA, NOAA and the FAA which address these phenomena are summarized

The contribution of next generation sequencing to epilepsy genetics

DEFF Research Database (Denmark)

Møller, Rikke S.; Dahl, Hans A.; Helbig, Ingo

2015-01-01

During the last decade, next generation sequencing technologies such as targeted gene panels, whole exome sequencing and whole genome sequencing have led to an explosion of gene identifications in monogenic epilepsies including both familial epilepsies and severe epilepsies, often referred to as ...

Converged Wireless Networking and Optimization for Next Generation Services

Directory of Open Access Journals (Sweden)

J. Rodriguez

2010-01-01

Full Text Available The Next Generation Network (NGN vision is tending towards the convergence of internet and mobile services providing the impetus for new market opportunities in combining the appealing services of internet with the roaming capability of mobile networks. However, this convergence does not go far enough, and with the emergence of new coexistence scenarios, there is a clear need to evolve the current architecture to provide cost-effective end-to-end communication. The LOOP project, a EUREKA-CELTIC driven initiative, is one piece in the jigsaw by helping European industry to sustain a leading role in telecommunications and manufacturing of high-value products and machinery by delivering pioneering converged wireless networking solutions that can be successfully demonstrated. This paper provides an overview of the LOOP project and the key achievements that have been tunneled into first prototypes for showcasing next generation services for operators and process manufacturers.

Cost and schedule reduction for next-generation Candu

International Nuclear Information System (INIS)

Hopwood, J.M.; Yu, S.; Pakan, M.; Soulard, M.

2002-01-01

AECL has developed a suite of technologies for Candu R reactors that enable the next step in the evolution of the Candu family of heavy-water-moderated fuel-channel reactors. These technologies have been combined in the design for the Advanced Candu Reactor TM1 (ACRTM), AECL's next generation Candu power plant. The ACR design builds extensively on the existing Candu experience base, but includes innovations, in design and in delivery technology, that provide very substantial reductions in capital cost and in project schedules. In this paper, main features of next generation design and delivery are summarized, to provide the background basis for the cost and schedule reductions that have been achieved. In particular the paper outlines the impact of the innovative design steps for ACR: - Selection of slightly enriched fuel bundle design; - Use of light water coolant in place of traditional Candu heavy water coolant; - Compact core design with unique reactor physics benefits; - Optimized coolant and turbine system conditions. In addition to the direct cost benefits arising from efficiency improvement, and from the reduction in heavy water, the next generation Candu configuration results in numerous additional indirect cost benefits, including: - Reduction in number and complexity of reactivity mechanisms; - Reduction in number of heavy water auxiliary systems; - Simplification in heat transport and its support systems; - Simplified human-machine interface. The paper also describes the ACR approach to design for constructability. The application of module assembly and open-top construction techniques, based on Candu and other worldwide experience, has been proven to generate savings in both schedule durations and overall project cost, by reducing premium on-site activities, and by improving efficiency of system and subsystem assembly. AECL's up-to-date experience in the use of 3-D CADDS and related engineering tools has also been proven to reduce both engineering and

Space Communications and Data Systems Technologies for Next Generation Earth Science Measurements

Science.gov (United States)

Bauer, Robert A.; Reinhart, Richard C.; Hilderman, Don R.; Paulsen, Phillip E.

2003-01-01

The next generation of Earth observing satellites and sensor networks will face challenges in supporting robust high rate communications links from the increasingly sophisticated onboard instruments. Emerging applications will need data rates forecast to be in the 100's to 1000's of Mbps. As mission designers seek smaller spacecraft, challenges exist in reducing the size and power requirements while increasing the capacity of the spacecraft's communications technologies. To meet these challenges, this work looks at three areas of selected space communications and data services technologies, specifically in the development of reflectarray antennas, demonstration of space Internet concepts, and measurement of atmospheric propagation effects on Ka-band signal transmitted from LEO.

Next-Generation Sequencing of Antibody Display Repertoires

Directory of Open Access Journals (Sweden)

Romain Rouet

2018-02-01

Full Text Available In vitro selection technology has transformed the development of therapeutic monoclonal antibodies. Using methods such as phage, ribosome, and yeast display, high affinity binders can be selected from diverse repertoires. Here, we review strategies for the next-generation sequencing (NGS of phage- and other antibody-display libraries, as well as NGS platforms and analysis tools. Moreover, we discuss recent examples relating to the use of NGS to assess library diversity, clonal enrichment, and affinity maturation.

Next-generation digital information storage in DNA.

Science.gov (United States)

Church, George M; Gao, Yuan; Kosuri, Sriram

2012-09-28

Digital information is accumulating at an astounding rate, straining our ability to store and archive it. DNA is among the most dense and stable information media known. The development of new technologies in both DNA synthesis and sequencing make DNA an increasingly feasible digital storage medium. We developed a strategy to encode arbitrary digital information in DNA, wrote a 5.27-megabit book using DNA microchips, and read the book by using next-generation DNA sequencing.

Popular Imagination and Identity Politics: Reading the Future in "Star Trek: The Next Generation."

Science.gov (United States)

Ott, Brian L.; Aoki, Eric

2001-01-01

Analyzes the television series "Star Trek: The Next Generation." Theorizes the relationship between collective visions of the future and the identity politics of the present. Argues that "The Next Generation" invites audiences to participate in a shared sense of the future that constrains human agency and (re)produces the…

Next Generation Life Support (NGLS): Rapid Cycle Amine Swing Bed

Data.gov (United States)

National Aeronautics and Space Administration — The Rapid Cycle Amine (RCA) swingbed has been identified as a technology with high potential to meet the stringent requirements for the next generation spacesuit's...

Modelling of control system architecture for next-generation accelerators

International Nuclear Information System (INIS)

Liu, Shi-Yao; Kurokawa, Shin-ichi

1990-01-01

Functional, hardware and software system architectures define the fundamental structure of control systems. Modelling is a protocol of system architecture used in system design. This paper reviews various modellings adopted in past ten years and suggests a new modelling for next generation accelerators. (author)

Next Generation UV Coronagraph Instrumentation for Solar Cycle-24

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... New concepts for next generation instrumentation include imaging ultraviolet spectrocoronagraphs and large aperture ultraviolet coronagraph spectrometers. An imaging instrument would be the first to obtain absolute spectral line intensities of the extended corona over a wide field of view. Such images ...

Power Electronics for the Next Generation Wind Turbine System

DEFF Research Database (Denmark)

Ma, Ke

This book presents recent studies on the power electronics used for the next generation wind turbine system. Some criteria and tools for evaluating and improving the critical performances of the wind power converters have been proposed and established. The book addresses some emerging problems...

The nuclear power industry's ageing workforce: Transfer of knowledge to the next generation

International Nuclear Information System (INIS)

2004-06-01

This report is intended primarily for senior and middle level managers in nuclear power plant operating organizations. It is intended to provide them practical information they can use to improve the transfer of knowledge from the current generation of NPP operating organization personnel to the next generation in an effective manner. The information provided in this report is based upon the experience of Member State operating organizations as well as other related industries. In September 2000, the IAEA held a technical meeting on the topic of an ageing workforce and declining educational infrastructures. The proceedings of this meeting were distributed on CD-ROM as Working Material. Several recent IAEA meetings including a senior level meeting held in June 2002 in Vienna and a technical session of the IAEA General Conference in September 2002 addressed methods of knowledge transfer. This is the first IAEA report published on this specific topic. In 2000, the IAEA Technical Working Group on the Training and Qualification of NPP Personnel (TWG-T and Q) suggested that the IAEA should develop a publication on the definition of core competencies to be maintained by an NPP operating organization. The TWG-T and Q suggested that this TECDOC should provide additional detail beyond that specified in the recently revised Safety Guide NS-G-2.8, Recruitment, Qualification and Training of Personnel for Nuclear Power Plants. This task was included in the approved programme for 2002-2003. In March 2001, IAEA-TECDOC-1204, A Systematic Approach to Human Performance Improvement: Training Solutions was published. This TECDOC provides a comprehensive list of core competencies. These competencies provide the additional detail beyond that specified in Safety Guide NS-G-2.8 that the TWG-T and Q had suggested. The aspect of core competencies that is not addressed in IAEA-TECDOC-1204 is how to effectively transfer these competencies to the generation that replaces the workforce that

Development of a framework for the neutronics analysis system for next generation (3)

International Nuclear Information System (INIS)

Yokoyama, Kenji; Hirai, Yasushi; Hyoudou, Hideaki; Tatsumi, Masahiro

2010-02-01

Development of innovative analysis methods and models in fundamental studies for next-generation nuclear reactor systems is in progress. In order to efficiently and effectively reflect the latest analysis methods and models to primary design of commercial reactor and/or in-core fuel management for power reactors, a next-generation analysis system MARBLE has been developed. The next-generation analysis system provides solutions to the following requirements: (1) flexibility, extensibility and user-friendliness that can apply new methods and models rapidly and effectively for fundamental studies, (2) quantitative proof of solution accuracy and adaptive scoping range for design studies, (3) coupling analysis among different study domains for the purpose of rationalization of plant systems and improvement of reliability, (4) maintainability and reusability for system extensions for the purpose of total quality management and development efficiency. The next-generation analysis system supports many fields, such as thermal-hydraulic analysis, structure analysis, reactor physics etc., and now we are studying reactor physics analysis system for fast reactor in advance. As for reactor physics analysis methods for fast reactor, we have established the JUPITER standard analysis methods based on the past study. But, there has been a problem of extreme inefficiency due to lack of functionality in the conventional analysis system when changing analysis targets and/or modeling levels. That is why, we have developed the next-generation analysis system for reactor physics which reproduces the JUPITER standard analysis method that has been developed so far and newly realizes burnup and design analysis for fast reactor and functions for cross section adjustment. In the present study, we examined in detail the existing design and implementation of ZPPR critical experiment analysis database followed by unification of models within the framework of the next-generation analysis system by

Microgrids in the Evolving Electricity Generation and DeliveryInfrastructure

Energy Technology Data Exchange (ETDEWEB)

Marnay, Chris; Venkataramanan, Giri

2006-02-01

The legacy paradigm for electricity service in most of the electrified world today is based on the centralized generation-transmission-distribution infrastructure that evolved under a regulated environment. More recently, a quest for effective economic investments, responsive markets, and sensitivity to the availability of resources, has led to various degrees of deregulation and unbundling of services. In this context, a new paradigm is emerging wherein electricity generation is intimately embedded with the load in microgrids. Development and decay of the familiar macrogrid is discussed. Three salient features of microgrids are examined to suggest that cohabitation of micro and macro grids is desirable, and that overall energy efficiency can be increased, while power is delivered to loads at appropriate levels of quality.

Next-generation Sequencing-based genomic profiling: Fostering innovation in cancer care?

Directory of Open Access Journals (Sweden)

Gustavo S. Fernandes

Full Text Available OBJECTIVES: With the development of next-generation sequencing (NGS technologies, DNA sequencing has been increasingly utilized in clinical practice. Our goal was to investigate the impact of genomic evaluation on treatment decisions for heavily pretreated patients with metastatic cancer. METHODS: We analyzed metastatic cancer patients from a single institution whose cancers had progressed after all available standard-of-care therapies and whose tumors underwent next-generation sequencing analysis. We determined the percentage of patients who received any therapy directed by the test, and its efficacy. RESULTS: From July 2013 to December 2015, 185 consecutive patients were tested using a commercially available next-generation sequencing-based test, and 157 patients were eligible. Sixty-six patients (42.0% were female, and 91 (58.0% were male. The mean age at diagnosis was 52.2 years, and the mean number of pre-test lines of systemic treatment was 2.7. One hundred and seventy-seven patients (95.6% had at least one identified gene alteration. Twenty-four patients (15.2% underwent systemic treatment directed by the test result. Of these, one patient had a complete response, four (16.7% had partial responses, two (8.3% had stable disease, and 17 (70.8% had disease progression as the best result. The median progression-free survival time with matched therapy was 1.6 months, and the median overall survival was 10 months. CONCLUSION: We identified a high prevalence of gene alterations using an next-generation sequencing test. Although some benefit was associated with the matched therapy, most of the patients had disease progression as the best response, indicating the limited biological potential and unclear clinical relevance of this practice.

Developing the next generation of nuclear workers at OPG

International Nuclear Information System (INIS)

Spekkens, P.

2007-01-01

This presentation is about developing the next generation of nuclear workers at Ontario Power Generation (OPG). Industry developments are creating urgent need to hire, train and retain new staff. OPG has an aggressive hiring campaign. Training organization is challenged to accommodate influx of new staff. Collaborating with colleges and universities is increasing the supply of qualified recruits with an interest in nuclear. Program for functional and leadership training have been developed. Knowledge retention is urgently required

Heterogeneous next-generation wireless network interference model-and its applications

KAUST Repository

Mahmood, Nurul Huda; Yilmaz, Ferkan; Alouini, Mohamed-Slim; Ø ien, Geir Egil

2014-01-01

Next-generation wireless systems facilitating better utilisation of the scarce radio spectrum have emerged as a response to inefficient and rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically

Epidemiological Studies to Support the Development of Next Generation Influenza Vaccines.

Science.gov (United States)

Petrie, Joshua G; Gordon, Aubree

2018-03-26

The National Institute of Allergy and Infectious Diseases recently published a strategic plan for the development of a universal influenza vaccine. This plan focuses on improving understanding of influenza infection, the development of influenza immunity, and rational design of new vaccines. Epidemiological studies such as prospective, longitudinal cohort studies are essential to the completion of these objectives. In this review, we discuss the contributions of epidemiological studies to our current knowledge of vaccines and correlates of immunity, and how they can contribute to the development and evaluation of the next generation of influenza vaccines. These studies have been critical in monitoring the effectiveness of current influenza vaccines, identifying issues such as low vaccine effectiveness, reduced effectiveness among those who receive repeated vaccination, and issues related to egg adaptation during the manufacturing process. Epidemiological studies have also identified population-level correlates of protection that can inform the design and development of next generation influenza vaccines. Going forward, there is an enduring need for epidemiological studies to continue advancing knowledge of correlates of protection and the development of immunity, to evaluate and monitor the effectiveness of next generation influenza vaccines, and to inform recommendations for their use.

Next generation multi-material 3D food printer concept

NARCIS (Netherlands)

Klomp, D.J.; Anderson, P.D.

2017-01-01

3D food printing is a new rapidly developing technology capable of creating food structures that are impossible to create with normal processing techniques. Challenges in this field are creating texture and multi-material food products. To address these challenges a next generation food printer will

Next-generation sequencing approaches to understanding the oral microbiome

NARCIS (Netherlands)

Zaura, E.

2012-01-01

Until recently, the focus in dental research has been on studying a small fraction of the oral microbiome—so-called opportunistic pathogens. With the advent of next-generation sequencing (NGS) technologies, researchers now have the tools that allow for profiling of the microbiomes and metagenomes at

From the Bench to the Bedside: The Role of Semantic Web and Translational Medicine for Enabling the Next Generation Healthcare Enterprise

Science.gov (United States)

Kashyap, Vipul

The success of new innovations and technologies are very often disruptive in nature. At the same time, they enable novel next generation infrastructures and solutions. These solutions introduce great efficiencies in the form of efficient processes and the ability to create, organize, share and manage knowledge effectively; and the same time provide crucial enablers for proposing and realizing new visions. In this paper, we propose a new vision of the next generation healthcare enterprise and discuss how Translational Medicine, which aims to improve communication between the basic and clinical sciences, is a key requirement for achieving this vision. This will lead therapeutic insights may be derived from new scientific ideas - and vice versa. Translation research goes from bench to bedside, where theories emerging from preclinical experimentation are tested on disease-affected human subjects, and from bedside to bench, where information obtained from preliminary human experimentation can be used to refine our understanding of the biological principles underpinning the heterogeneity of human disease and polymorphism(s). Informatics and semantic technologies in particular, has a big role to play in making this a reality. We identify critical requirements, viz., data integration, clinical decision support and knowledge maintenance and provenance; and illustrate semantics-based solutions wrt example scenarios and use cases.

Evaluating multiplexed next-generation sequencing as a method in palynology for mixed pollen samples.

Science.gov (United States)

Keller, A; Danner, N; Grimmer, G; Ankenbrand, M; von der Ohe, K; von der Ohe, W; Rost, S; Härtel, S; Steffan-Dewenter, I

2015-03-01

The identification of pollen plays an important role in ecology, palaeo-climatology, honey quality control and other areas. Currently, expert knowledge and reference collections are essential to identify pollen origin through light microscopy. Pollen identification through molecular sequencing and DNA barcoding has been proposed as an alternative approach, but the assessment of mixed pollen samples originating from multiple plant species is still a tedious and error-prone task. Next-generation sequencing has been proposed to avoid this hindrance. In this study we assessed mixed pollen probes through next-generation sequencing of amplicons from the highly variable, species-specific internal transcribed spacer 2 region of nuclear ribosomal DNA. Further, we developed a bioinformatic workflow to analyse these high-throughput data with a newly created reference database. To evaluate the feasibility, we compared results from classical identification based on light microscopy from the same samples with our sequencing results. We assessed in total 16 mixed pollen samples, 14 originated from honeybee colonies and two from solitary bee nests. The sequencing technique resulted in higher taxon richness (deeper assignments and more identified taxa) compared to light microscopy. Abundance estimations from sequencing data were significantly correlated with counted abundances through light microscopy. Simulation analyses of taxon specificity and sensitivity indicate that 96% of taxa present in the database are correctly identifiable at the genus level and 70% at the species level. Next-generation sequencing thus presents a useful and efficient workflow to identify pollen at the genus and species level without requiring specialised palynological expert knowledge. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

Big Data Perspective and Challenges in Next Generation Networks

Directory of Open Access Journals (Sweden)

Kashif Sultan

2018-06-01

Full Text Available With the development towards the next generation cellular networks, i.e., 5G, the focus has shifted towards meeting the higher data rate requirements, potential of micro cells and millimeter wave spectrum. The goals for next generation networks are very high data rates, low latency and handling of big data. The achievement of these goals definitely require newer architecture designs, upgraded technologies with possible backward support, better security algorithms and intelligent decision making capability. In this survey, we identify the opportunities which can be provided by 5G networks and discuss the underlying challenges towards implementation and realization of the goals of 5G. This survey also provides a discussion on the recent developments made towards standardization, the architectures which may be potential candidates for deployment and the energy concerns in 5G networks. Finally, the paper presents a big data perspective and the potential of machine learning for optimization and decision making in 5G networks.

Carrier ethernet network control plane based on the Next Generation Network

DEFF Research Database (Denmark)

Fu, Rong; Wang, Yanmeng; Berger, Michael Stubert

2008-01-01

This paper contributes on presenting a step towards the realization of Carrier Ethernet control plane based on the next generation network (NGN). Specifically, transport MPLS (T-MPLS) is taken as the transport technology in Carrier Ethernet. It begins with providing an overview of the evolving...... architecture of the next generation network (NGN). As an essential candidate among the NGN transport technologies, the definition of Carrier Ethernet (CE) is also introduced here. The second part of this paper depicts the contribution on the T-MPLS based Carrier Ethernet network with control plane based on NGN...... at illustrating the improvement of the Carrier Ethernet network with the NGN control plane....

Development of source term evaluation method for Korean Next Generation Reactor

Energy Technology Data Exchange (ETDEWEB)

Lee, Keon Jae; Cheong, Jae Hak; Park, Jin Baek; Kim, Guk Gee [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

1997-10-15

This project had investigate several design features of radioactive waste processing system and method to predict nuclide concentration at primary coolant basic concept of next generation reactor and safety goals at the former phase. In this project several prediction methods of source term are evaluated conglomerately and detailed contents of this project are : model evaluation of nuclide concentration at Reactor Coolant System, evaluation of primary and secondary coolant concentration of reference Nuclear Power Plant(NPP), investigation of prediction parameter of source term evaluation, basic parameter of PWR, operational parameter, respectively, radionuclide removal system and adjustment values of reference NPP, suggestion of source term prediction method of next generation NPP.

Next generation of relativistic heavy ion accelerators

International Nuclear Information System (INIS)

Grunder, H.; Leemann, C.; Selph, F.

1978-06-01

Results are presented of exploratory and preliminary studies of a next generation of heavy ion accelerators. The conclusion is reached that useful luminosities are feasible in a colliding beam facility for relativistic heavy ions. Such an accelerator complex may be laid out in such a way as to provide extractebeams for fixed target operation, therefore allowing experimentation in an energy region overlapping with that presently available. These dual goals seem achievable without undue complications, or penalties with respect to cost and/or performance

Thermonuclear ignition in the next generation tokamaks

International Nuclear Information System (INIS)

Johner, J.

1989-04-01

The extrapolation of experimental rules describing energy confinement and magnetohydrodynamic - stability limits, in known tokamaks, allow to show that stable thermonuclear ignition equilibria should exist in this configuration, if the product aB t x of the dimensions by a magnetic-field power is large enough. Quantitative application of this result to several next-generation tokamak projects show that those kinds of equilibria could exist in such devices, which would also have enough additional heating power to promote an effective accessible ignition

Polymeric Nanocomposite Membranes for Next Generation Pervaporation Process: Strategies, Challenges and Future Prospects

Directory of Open Access Journals (Sweden)

Sagar Roy

2017-09-01

Full Text Available Pervaporation (PV has been considered as one of the most active and promising areas in membrane technologies in separating close boiling or azeotropic liquid mixtures, heat sensitive biomaterials, water or organics from its mixtures that are indispensable constituents for various important chemical and bio-separations. In the PV process, the membrane plays the most pivotal role and is of paramount importance in governing the overall efficiency. This article evaluates and collaborates the current research towards the development of next generation nanomaterials (NMs and embedded polymeric membranes with regard to its synthesis, fabrication and application strategies, challenges and future prospects.

Polymeric Nanocomposite Membranes for Next Generation Pervaporation Process: Strategies, Challenges and Future Prospects.

Science.gov (United States)

Roy, Sagar; Singha, Nayan Ranjan

2017-09-08

Pervaporation (PV) has been considered as one of the most active and promising areas in membrane technologies in separating close boiling or azeotropic liquid mixtures, heat sensitive biomaterials, water or organics from its mixtures that are indispensable constituents for various important chemical and bio-separations. In the PV process, the membrane plays the most pivotal role and is of paramount importance in governing the overall efficiency. This article evaluates and collaborates the current research towards the development of next generation nanomaterials (NMs) and embedded polymeric membranes with regard to its synthesis, fabrication and application strategies, challenges and future prospects.

Next Generation Antibody Therapeutics Using Bispecific Antibody Technology.

Science.gov (United States)

Igawa, Tomoyuki

2017-01-01

Nearly fifty monoclonal antibodies have been approved to date, and the market for monoclonal antibodies is expected to continue to grow. Since global competition in the field of antibody therapeutics is intense, we need to establish novel antibody engineering technologies to provide true benefit for patients, with differentiated product values. Bispecific antibodies are among the next generation of antibody therapeutics that can bind to two different target antigens by the two arms of immunoglobulin G (IgG) molecule, and are thus believed to be applicable to various therapeutic needs. Until recently, large scale manufacturing of human IgG bispecific antibody was impossible. We have established a technology, named asymmetric re-engineering technology (ART)-Ig, to enable large scale manufacturing of bispecific antibodies. Three examples of next generation antibody therapeutics using ART-Ig technology are described. Recent updates on bispecific antibodies against factor IXa and factor X for the treatment of hemophilia A, bispecific antibodies against a tumor specific antigen and T cell surface marker CD3 for cancer immunotherapy, and bispecific antibodies against two different epitopes of soluble antigen with pH-dependent binding property for the elimination of soluble antigen from plasma are also described.

Feasibility and application on steam injector for next-generation reactor

International Nuclear Information System (INIS)

Narabayashi, Tadashi; Ishiyama, Takenori; Miyano, Hiroshi; Nei, Hiromichi; Shioiri, Akio

1991-01-01

A feasibility study has been conducted on steam injector for a next generation reactor. The steam injector is a simple, compact passive device for water injection, such as Passive Core Injection System (PCIS) of Passive Containment Cooling System (PCCS), because of easy start-up without an AC power. An analysis model for a steam injector characteristics has been developed, and investigated with a visualized fundamental test for a two-stage Steam Injector System (SIS) for PCIS and a one-stage low pressure SIS for PCCS. The test results showed good agreement with the analysis results. The analysis and the test results showed the SIS could work over a very wide range of the steam pressure, and is applicable for PCIS or PCCS in the next generation reactors. (author)

Results of Analyses of the Next Generation Solvent for Parsons

International Nuclear Information System (INIS)

Peters, T.; Washington, A.; Fink, S.

2012-01-01

Savannah River National Laboratory (SRNL) prepared a nominal 150 gallon batch of Next Generation Solvent (NGS) for Parsons. This material was then analyzed and tested for cesium mass transfer efficiency. The bulk of the results indicate that the solvent is qualified as acceptable for use in the upcoming pilot-scale testing at Parsons Technology Center. This report describes the analysis and testing of a batch of Next Generation Solvent (NGS) prepared in support of pilot-scale testing in the Parsons Technology Center. A total of ∼150 gallons of NGS solvent was prepared in late November of 2011. Details for the work are contained in a controlled laboratory notebook. Analysis of the Parsons NGS solvent indicates that the material is acceptable for use. SRNL is continuing to improve the analytical method for the guanidine.

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

NARCIS (Netherlands)

K.M. Hettne (Kristina); J. Boorsma (Jeffrey); D.A.M. van Dartel (Dorien A M); J.J. Goeman (Jelle); E.C. de Jong (Esther); A.H. Piersma (Aldert); R.H. Stierum (Rob); J. Kleinjans (Jos); J.A. Kors (Jan)

2013-01-01

textabstractBackground: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with

The "Next Generation Science Standards" and the Life Sciences

Science.gov (United States)

Bybee, Rodger W.

2013-01-01

Publication of the "Next Generation Science Standards" will be just short of two decades since publication of the "National Science Education Standards" (NRC 1996). In that time, biology and science education communities have advanced, and the new standards will reflect that progress (NRC 1999, 2007, 2009; Kress and Barrett…

Electric vehicle charge patterns and the electricity generation mix and competitiveness of next generation vehicles

International Nuclear Information System (INIS)

Masuta, Taisuke; Murata, Akinobu; Endo, Eiichi

2014-01-01

Highlights: • The energy system of whole of Japan is analyzed in this study. • An advanced model based on MARKAL is used for the energy system analysis. • The impact of charge patterns of EVs on electricity generation mix is evaluated. • Technology competitiveness of the next generation vehicles is also evaluated. - Abstract: The nuclear accident of 2011 brought about a reconsideration of the future electricity generation mix of power systems in Japan. A debate on whether to phase out nuclear power plants and replace them with renewable energy sources is taking place. Demand-side management becomes increasingly important in future Japanese power systems with a large-scale integration of renewable energy sources. This paper considers the charge control of electric vehicles (EVs) through demand-side management. There have been many studies of the control or operation methods of EVs known as vehicle-to-grid (V2G), and it is important to evaluate both their short-term and long-term operation. In this study, we employ energy system to evaluate the impact of the charge patterns of EVs on both the electricity generation mix and the technology competitiveness of the next generation vehicles. An advanced energy system model based on Market Allocation (MARKAL) is used to consider power system control in detail

Modeling the video distribution link in the Next Generation Optical Access Networks

International Nuclear Information System (INIS)

Amaya, F; Cardenas, A; Tafur, I

2011-01-01

In this work we present a model for the design and optimization of the video distribution link in the next generation optical access network. We analyze the video distribution performance in a SCM-WDM link, including the noise, the distortion and the fiber optic nonlinearities. Additionally, we consider in the model the effect of distributed Raman amplification, used to extent the capacity and the reach of the optical link. In the model, we use the nonlinear Schroedinger equation with the purpose to obtain capacity limitations and design constrains of the next generation optical access networks.

Supporting Infrastructure and Acceptability Issues for Materials Used in New Generation Vehicles

Energy Technology Data Exchange (ETDEWEB)

Das, S.; Curlee, T.R.; Jones, D.W.; Leiby, P.E.; Rubin, J.D.; Schexnayder, S.M.; Vogt, D.P.; Wolfe, A.K.

1999-03-01

To achieve its goal of producing vehicles that use two thirds less fuel than current vehicles, the Partnership of a New Generation of Vehicles (PNGV) is designing vehicles that will use lightweight materials in place of heavier materials used in current vehicles. using new materials in automobiles will require the development of a supporting infrastructure to produce both the substitute materials and the components of the substitute materials, as well as the automotive parts constructed from the new materials. This report documents a set of analyses that attempt to identify potential barriers--economic, infrastructure, and public acceptance barriers--to the materials substitution in New Generation Vehicles. The analyses rely on hypothetical vehicle market penetration scenarios and material composition. The approach is comprehensive, examining issues ranging from materials availability to their eventual disposition and its effect on the automobile recycling industry, and from supporting industries' capacity to the public acceptability of these vehicles. The analyses focus on two likely substitute materials, aluminum and glass-reinforced polymer composites.

The study of methodologies of software development for the next generation of HEP detector software

International Nuclear Information System (INIS)

Ding Yuzheng; Wang Taijie; Dai Guiliang

1997-01-01

The author discusses the characteristics of the next generation of HEP (High Energy Physics) detector software, and describes the basic strategy for the usage of object oriented methodologies, languages and tools in the development of the next generation of HEP detector software

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

NARCIS (Netherlands)

Hettne, K.M.; Boorsma, A.; Dartel, D.A. van; Goeman, J.J.; Jong, E. de; Piersma, A.H.; Stierum, R.H.; Kleinjans, J.C.; Kors, J.A.

2013-01-01

BACKGROUND: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set

Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data

NARCIS (Netherlands)

Hettne, K.M.; Boorsma, A.; Dartel, van D.A.M.; Goeman, J.J.; Jong, de E.; Piersma, A.H.; Stierum, R.H.; Kleinjans, J.C.; Kors, J.A.

2013-01-01

Background: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set

Multiple Access Techniques for Next Generation Wireless: Recent Advances and Future Perspectives

Directory of Open Access Journals (Sweden)

Shree Krishna Sharma

2016-01-01

Full Text Available The advances in multiple access techniques has been one of the key drivers in moving from one cellular generation to another. Starting from the first generation, several multiple access techniques have been explored in different generations and various emerging multiplexing/multiple access techniques are being investigated for the next generation of cellular networks. In this context, this paper first provides a detailed review on the existing Space Division Multiple Access (SDMA related works. Subsequently, it highlights the main features and the drawbacks of various existing and emerging multiplexing/multiple access techniques. Finally, we propose a novel concept of clustered orthogonal signature division multiple access for the next generation of cellular networks. The proposed concept envisions to employ joint antenna coding in order to enhance the orthogonality of SDMA beams with the objective of enhancing the spectral efficiency of future cellular networks.

Next generation science standards available for comment

Science.gov (United States)

Asher, Pranoti

2012-05-01

The first public draft of the Next Generation Science Standards (NGSS) is now available for public comment. Feedback on the standards is sought from people who have a stake in science education, including individuals in the K-12, higher education, business, and research communities. Development of NGSS is a state-led effort to define the content and practices students need to learn from kindergarten through high school. NGSS will be based on the U.S. National Research Council's reportFramework for K-12 Science Education.

Design Principles of Next-Generation Digital Gaming for Education.

Science.gov (United States)

Squire, Kurt; Jenkins, Henry; Holland, Walter; Miller, Heather; O'Driscoll, Alice; Tan, Katie Philip; Todd, Katie.

2003-01-01

Discusses the rapid growth of digital games, describes research at MIT that is exploring the potential of digital games for supporting learning, and offers hypotheses about the design of next-generation educational video and computer games. Highlights include simulations and games; and design principles, including context and using information to…

75 FR 82387 - Next Generation Risk Assessment Public Dialogue Conference

Science.gov (United States)

2010-12-30

... ENVIRONMENTAL PROTECTION AGENCY [FRL-9246-7] Next Generation Risk Assessment Public Dialogue Conference AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of Public Dialogue Conference... methods with the National Institutes of Environmental Health Sciences' National Toxicology Program, Center...

Quantitative miRNA expression analysis: comparing microarrays with next-generation sequencing

DEFF Research Database (Denmark)

Willenbrock, Hanni; Salomon, Jesper; Søkilde, Rolf

2009-01-01

Recently, next-generation sequencing has been introduced as a promising, new platform for assessing the copy number of transcripts, while the existing microarray technology is considered less reliable for absolute, quantitative expression measurements. Nonetheless, so far, results from the two...... technologies have only been compared based on biological data, leading to the conclusion that, although they are somewhat correlated, expression values differ significantly. Here, we use synthetic RNA samples, resembling human microRNA samples, to find that microarray expression measures actually correlate...... better with sample RNA content than expression measures obtained from sequencing data. In addition, microarrays appear highly sensitive and perform equivalently to next-generation sequencing in terms of reproducibility and relative ratio quantification....

RIPng- A next Generation Routing Protocal (IPv6) | Falaye | Journal ...

African Journals Online (AJOL)

... Information Protocol Next Generation (RIPng) owing to the current depletion rate of IPv4. ... that support the Internet Protocol Version 6 (IPv6).addressing scheme. ... A brief history is given; its various versions are discussed, and detailed ...

Clinical utility of a 377 gene custom next-generation sequencing ...

Indian Academy of Sciences (India)

JEN BEVILACQUA

2017-07-26

Jul 26, 2017 ... Clinical utility of a 377 gene custom next-generation sequencing epilepsy panel ... number of genes, making it a very attractive option for a condition as .... clinical value of various test offerings to guide decision making.

AgMIP: Next Generation Models and Assessments

Science.gov (United States)

Rosenzweig, C.

2014-12-01

Next steps in developing next-generation crop models fall into several categories: significant improvements in simulation of important crop processes and responses to stress; extension from simplified crop models to complex cropping systems models; and scaling up from site-based models to landscape, national, continental, and global scales. Crop processes that require major leaps in understanding and simulation in order to narrow uncertainties around how crops will respond to changing atmospheric conditions include genetics; carbon, temperature, water, and nitrogen; ozone; and nutrition. The field of crop modeling has been built on a single crop-by-crop approach. It is now time to create a new paradigm, moving from 'crop' to 'cropping system.' A first step is to set up the simulation technology so that modelers can rapidly incorporate multiple crops within fields, and multiple crops over time. Then the response of these more complex cropping systems can be tested under different sustainable intensification management strategies utilizing the updated simulation environments. Model improvements for diseases, pests, and weeds include developing process-based models for important diseases, frameworks for coupling air-borne diseases to crop models, gathering significantly more data on crop impacts, and enabling the evaluation of pest management strategies. Most smallholder farming in the world involves integrated crop-livestock systems that cannot be represented by crop modeling alone. Thus, next-generation cropping system models need to include key linkages to livestock. Livestock linkages to be incorporated include growth and productivity models for grasslands and rangelands as well as the usual annual crops. There are several approaches for scaling up, including use of gridded models and development of simpler quasi-empirical models for landscape-scale analysis. On the assessment side, AgMIP is leading a community process for coordinated contributions to IPCC AR6

Next-Generation Aura/OMI NO2 and SO2 Products

Science.gov (United States)

Krotkov, Nickolay; Yang, Kai; Bucsela, Eric; Lamsal, Lok; Celarier, Edward; Swartz, William; Carn, Simon; Bhartia, Pawan; Gleason, James; Pickering, Ken;

The Next Generation Science Standards: The Features and Challenges

Science.gov (United States)

Pruitt, Stephen L.

2014-01-01

Beginning in January of 2010, the Carnegie Corporation of New York funded a two-step process to develop a new set of state developed science standards intended to prepare students for college and career readiness in science. These new internationally benchmarked science standards, the Next Generation Science Standards (NGSS) were completed in…

"ASTRO 101" Course Materials 2.0: Next Generation Lecture Tutorials and Beyond

Science.gov (United States)

Slater, Stephanie; Grazier, Kevin

2015-01-01

Early efforts to create course materials were often local in scale and were based on "gut instinct," and classroom experience and observation. While subsequent efforts were often based on those same instincts and observations of classrooms, they also incorporated the results of many years of education research. These "second generation" course materials, such as lecture tutorials, relied heavily on research indicating that instructors need to actively engage students in the learning process. While imperfect, these curricular innovations, have provided evidence that research-based materials can be constructed, can easily be disseminated to a broad audience, and can provide measureable improvement in student learning across many settings. In order to improve upon this prior work, next generation materials must build upon the strengths of these innovations while engineering in findings from education research, cognitive science, and instructor feedback. A next wave of materials, including a set of next generation lecture tutorials, have been constructed with attention to the body of research on student motivation, and cognitive load; and they are responsive to our body of knowledge on learning difficulties related to specific content in the domain. From instructor feedback, these materials have been constructed to have broader coverage of the materials typically taught in an ASTRO 101 course, to take less class time, and to be more affordable for students. This next generation of lecture tutorials may serve as a template of the ways in which course materials can be reengineered to respond to current instructor and student needs.

Next generation Zero-Code control system UI

CERN Multimedia

CERN. Geneva

2017-01-01

Developing ergonomic user interfaces for control systems is challenging, especially during machine upgrade and commissioning where several small changes may suddenly be required. Zero-code systems, such as *Inspector*, provide agile features for creating and maintaining control system interfaces. More so, these next generation Zero-code systems bring simplicity and uniformity and brake the boundaries between Users and Developers. In this talk we present *Inspector*, a CERN made Zero-code application development system, and we introduce the major differences and advantages of using Zero-code control systems to develop operational UI.

Beamstrahlung spectra in next generation linear colliders

Energy Technology Data Exchange (ETDEWEB)

Barklow, T.; Chen, P. (Stanford Linear Accelerator Center, Menlo Park, CA (United States)); Kozanecki, W. (DAPNIA-SPP, CEN-Saclay (France))

1992-04-01

For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles. In this paper, we first derive analytical formulae for the electron and photon energy spectra under multiple beamstrahlung processes, and for the e{sup +}e{sup {minus}} and {gamma}{gamma} differential luminosities. We then apply our formulation to various classes of 500 GeV e{sup +}e{sup {minus}} linear collider designs currently under study.

Thermal management of next-generation contact-cooled synchrotron x-ray mirrors

Energy Technology Data Exchange (ETDEWEB)

Khounsary, A.

1999-10-29

In the past decade, several third-generation synchrotrons x-ray sources have been constructed and commissioned around the world. Many of the major problems in the development and design of the optical components capable of handling the extremely high heat loads of the generated x-ray beams have been resolved. It is expected, however, that in the next few years even more powerful x-ray beams will be produced at these facilities, for example, by increasing the particle beam current. In this paper, the design of a next generation of synchrotron x-ray mirrors is discussed. The author shows that the design of contact-cooled mirrors capable of handing x-ray beam heat fluxes in excess of 500 W/mm{sup 2} - or more than three times the present level - is well within reach, and the limiting factor is the thermal stress rather then thermally induced slope error.

C-Arc: A Novel Architecture for Next Generation Context- Aware ...

African Journals Online (AJOL)

In this paper, the common architecture principles of context-aware systems are presented and the crucial contextaware architecture issues to support the next generation context-aware systems which will enable seamless service provisioning in heterogeneous, dynamically varying computing and communication ...

Tablet—next generation sequence assembly visualization

Science.gov (United States)

Milne, Iain; Bayer, Micha; Cardle, Linda; Shaw, Paul; Stephen, Gordon; Wright, Frank; Marshall, David

2010-01-01

Summary: Tablet is a lightweight, high-performance graphical viewer for next-generation sequence assemblies and alignments. Supporting a range of input assembly formats, Tablet provides high-quality visualizations showing data in packed or stacked views, allowing instant access and navigation to any region of interest, and whole contig overviews and data summaries. Tablet is both multi-core aware and memory efficient, allowing it to handle assemblies containing millions of reads, even on a 32-bit desktop machine. Availability: Tablet is freely available for Microsoft Windows, Apple Mac OS X, Linux and Solaris. Fully bundled installers can be downloaded from http://bioinf.scri.ac.uk/tablet in 32- and 64-bit versions. Contact: tablet@scri.ac.uk PMID:19965881

Modeling the video distribution link in the Next Generation Optical Access Networks

DEFF Research Database (Denmark)

Amaya, F.; Cárdenas, A.; Tafur Monroy, Idelfonso

2011-01-01

In this work we present a model for the design and optimization of the video distribution link in the next generation optical access network. We analyze the video distribution performance in a SCM-WDM link, including the noise, the distortion and the fiber optic nonlinearities. Additionally, we...... consider in the model the effect of distributed Raman amplification, used to extent the capacity and the reach of the optical link. In the model, we use the nonlinear Schrödinger equation with the purpose to obtain capacity limitations and design constrains of the next generation optical access networks....

NEXT GENERATION TURBINE SYSTEM STUDY

Energy Technology Data Exchange (ETDEWEB)

Frank Macri

2002-02-28

Rolls-Royce has completed a preliminary design and marketing study under a Department of Energy (DOE) cost shared contract (DE-AC26-00NT40852) to analyze the feasibility of developing a clean, high efficiency, and flexible Next Generation Turbine (NGT) system to meet the power generation market needs of the year 2007 and beyond. Rolls-Royce evaluated the full range of its most advanced commercial aerospace and aeroderivative engines alongside the special technologies necessary to achieve the aggressive efficiency, performance, emissions, economic, and flexibility targets desired by the DOE. Heavy emphasis was placed on evaluating the technical risks and the economic viability of various concept and technology options available. This was necessary to ensure the resulting advanced NGT system would provide extensive public benefits and significant customer benefits without introducing unacceptable levels of technical and operational risk that would impair the market acceptance of the resulting product. Two advanced cycle configurations were identified as offering significant advantages over current combined cycle products available in the market. In addition, balance of plant (BOP) technologies, as well as capabilities to improve the reliability, availability, and maintainability (RAM) of industrial gas turbine engines, have been identified. A customer focused survey and economic analysis of a proposed Rolls-Royce NGT product configuration was also accomplished as a part of this research study. The proposed Rolls-Royce NGT solution could offer customers clean, flexible power generation systems with very high efficiencies, similar to combined cycle plants, but at a much lower specific cost, similar to those of simple cycle plants.

Promising Practices: Building the Next Generation of School Leaders

Science.gov (United States)

Bryant, Jennifer Edic; Escalante, Karen; Selva, Ashley

2017-01-01

This study applies transformational leadership theory practices to examine the purposeful ways in which principals work to build the next generation of teacher leaders in response to the shortage of K-12 principals. Given the impact principals have on student development and the shortage of those applying for the principalship, the purpose of this…

Safety reviews of next-generation light-water reactors

International Nuclear Information System (INIS)

Kudrick, J.A.; Wilson, J.N.

1997-01-01

The Nuclear Regulatory Commission (NRC) is reviewing three applications for design certification under its new licensing process. The U.S. Advanced Boiling Water Reactor (ABWR) and System 80+ designs have received final design approvals. The AP600 design review is continuing. The goals of design certification are to achieve early resolution of safety issues and to provide a more stable and predictable licensing process. NRC also reviewed the Utility Requirements Document (URD) of the Electric Power Research Institute (EPRI) and determined that its guidance does not conflict with NRC requirements. This review led to the identification and resolution of many generic safety issues. The NRC determined that next-generation reactor designs should achieve a higher level of safety for selected technical and severe accident issues. Accordingly, NRC developed new review standards for these designs based on (1) operating experience, including the accident at Three Mile Island, Unit 2; (2) the results of probabilistic risk assessments of current and next-generation reactor designs; (3) early efforts on severe accident rulemaking; and (4) research conducted to address previously identified generic safety issues. The additional standards were used during the individual design reviews and the resolutions are documented in the design certification rules. 12 refs

Towards Next Generation Internet Management:CNGI-CERNET2EXPERIENCES

Institute of Scientific and Technical Information of China (English)

Jia-Hai Yang; Hui Zhang; Jin-Xiang Zhang; Chang-Qing An

2009-01-01

Manageability is an important feature of next generation Internet; management and monitoring of IPv6-based networks are proving a big challenge. While leveraging current IPv4-based SNMP management scheme to IPv6 networks'management need is necessary, it is more urgent to coin a new network management architecture to accommodate the scalability and extensibility requirements of next generation Internet management. The paper proposes a novel network management architecture, IMN (Internet Management Network), which creates an overlay network of management nodes.While each management node can perform management tasks autonomously and independently, it can finish more sophis-ticated management tasks by collaboratively invoking management operations or sharing information provided by other management nodes. P2P-based communication services are introduced in IMN to enable such collaboration. The paper presents a prototyping implementation based on the Web service related technology, as well as some of the key technologies,especially solutions to those issues arising from the management practice of CERNET2. Experiences of deployment of CERNET2 operation and lessons learned from the management practice are discussed.

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Directory of Open Access Journals (Sweden)

Patrice D. Cani

2017-09-01

Full Text Available Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Besides the numerous correlations observed, a large body of evidence has demonstrated the causal beneficial impact of this bacterium in a variety of preclinical models. Translating these exciting observations to human would be the next logic step and it now appears that several obstacles that would prevent the use of A. muciniphila administration in humans have been overcome. Moreover, several lines of evidence indicate that pasteurization of A. muciniphila not only increases its stability but more importantly increases its efficacy. This strongly positions A. muciniphila in the forefront of next-generation candidates for developing novel food or pharma supplements with beneficial effects. Finally, a specific protein present on the outer membrane of A. muciniphila, termed Amuc_1100, could be strong candidate for future drug development. In conclusion, as plants and its related knowledge, known as pharmacognosy, have been the source for designing drugs over the last century, we propose that microbes and microbiomegnosy, or knowledge of our gut microbiome, can become a novel source of future therapies.

Next-Generation Ultra-Compact Stowage/Lightweight Solar Array System, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Deployable Space Systems, Inc. (DSS) has developed a next-generation high performance solar array system that has game-changing performance metrics in terms of...

The Dynamic Pricing of Next Generation Consumer Durables

OpenAIRE

Barry L. Bayus

1992-01-01

Learning curve effects, aspects of consumer demand models (e.g., reservation price distributions, intertemporal utility maximizing behavior), and competitive activity are reasons which have been offered to explain why prices of new durables decline over time. This paper presents an alternative rationale based on the buying behavior for products with overlapping replacement cycles (i.e., next generation products). A model for consumer sales of a new durable is developed by incorporating the re...

Next Generation RFID-Based Medical Service Management System Architecture in Wireless Sensor Network

Science.gov (United States)

Tolentino, Randy S.; Lee, Kijeong; Kim, Yong-Tae; Park, Gil-Cheol

Radio Frequency Identification (RFID) and Wireless Sensor Network (WSN) are two important wireless technologies that have wide variety of applications and provide unlimited future potentials most especially in healthcare systems. RFID is used to detect presence and location of objects while WSN is used to sense and monitor the environment. Integrating RFID with WSN not only provides identity and location of an object but also provides information regarding the condition of the object carrying the sensors enabled RFID tag. However, there isn't any flexible and robust communication infrastructure to integrate these devices into an emergency care setting. An efficient wireless communication substrate for medical devices that addresses ad hoc or fixed network formation, naming and discovery, transmission efficiency of data, data security and authentication, as well as filtration and aggregation of vital sign data need to be study and analyze. This paper proposed an efficient next generation architecture for RFID-based medical service management system in WSN that possesses the essential elements of each future medical application that are integrated with existing medical practices and technologies in real-time, remote monitoring, in giving medication, and patient status tracking assisted by embedded wearable wireless sensors which are integrated in wireless sensor network.

On reactor type comparisons for the next generation of reactors

International Nuclear Information System (INIS)

Alesso, H.P.; Majumdar, K.C.

1991-01-01

In this paper, we present a broad comparison of studies for a selected set of parameters for different nuclear reactor types including the next generation. This serves as an overview of key parameters which provide a semi-quantitative decision basis for selecting nuclear strategies. Out of a number of advanced reactor designs of the LWR type, gas cooled type, and FBR type, currently on the drawing board, the Advanced Light Water Reactors (ALWR) seem to have some edge over other types of the next generation of reactors for the near-term application. This is based on a number of attributes related to the benefit of the vast operating experience with LWRs coupled with an estimated low risk profile, economics of scale, degree of utilization of passive systems, simplification in the plant design and layout, modular fabrication and manufacturing. 32 refs., 1 fig., 3 tabs

A Vision for Open Cyber-Scholarly Infrastructures

Directory of Open Access Journals (Sweden)

Costantino Thanos

2016-05-01

Full Text Available The characteristics of modern science, i.e., data-intensive, multidisciplinary, open, and heavily dependent on Internet technologies, entail the creation of a linked scholarly record that is online and open. Instrumental in making this vision happen is the development of the next generation of Open Cyber-Scholarly Infrastructures (OCIs, i.e., enablers of an open, evolvable, and extensible scholarly ecosystem. The paper delineates the evolving scenario of the modern scholarly record and describes the functionality of future OCIs as well as the radical changes in scholarly practices including new reading, learning, and information-seeking practices enabled by OCIs.

R&D, Marketing, and the Success of Next-Generation Products

OpenAIRE

Elie Ofek; Miklos Sarvary

2003-01-01

This paper studies dynamic competition in markets characterized by the introduction of technologically advanced next-generation products. Firms invest in new product effort in an attempt to attain industry leadership, thus securing high profits and benefiting from advantages relevant for the success of future product generations. The analysis reveals that when the current leader possesses higher research and development (R&D) competence, it tends to investin R&D than rivals and to retain its ...

OLEDs : Technology's next generation

Energy Technology Data Exchange (ETDEWEB)

Anon

2001-10-01

Major advances in organic light emitting device (OLED) technology are bringing some science fiction concepts to the brink of reality. At the moment. OLED technology is being developed for the flat panel display industry. Liquid crystal display dominates the market for wristwatches and cellular phones for example, while the cathode ray tube plays the same role for television sets and desktop computers. Both have limitations when it comes to meeting the needs of the next generation of smart products. The attributes required include high brightness, low power consumption, high definition, full colour, wide preview angle, fast response time and portability, and low cost. OLED has the potential to meet all those requirements. Universal Display Corporation (UDC) was founded, and specializes in the development and commercialization of OLED technology. A partnership was established early with Princeton University professors, and no fewer than 20 researchers are working on OLED technology projects at both Princeton University and the University of Southern California. To date, 35 patents have been issued, and 60 others are pending. A joint development agreement was reached with Sony Corporation this year for high efficiency active matrix OLEDs to be used in large area monitor applications. OLED technology is based on vacuum-deposited organic small molecule materials that emit very bright light when electrically stimulated. Three advances in the technology were briefly discussed: TOLED{sup TM} for Transparent OLED, SOLED{sup TM} for Stacked OLED, and FOLED{sup TM} for Flexible OLED. A list detailing the various potential uses for the technology was also included in this paper. 3 figs.

Common Core State Standards for ELA/Literacy and Next Generation Science Standards: Convergences and Discrepancies Using Argument as an Example

Science.gov (United States)

Lee, Okhee

2017-01-01

As the Common Core State Standards (CCSS) for English language arts (ELA)/literacy and the Next Generation Science Standards (NGSS) highlight connections across subject areas, convergences and discrepancies come into view. As a prominent example, this article focuses on how the CCSS and the NGSS treat "argument," especially in Grades…

Developments of next generation of seafloor observatories in MARsite project

Science.gov (United States)

Italiano, Francesco; Favali, Paolo; Zaffuto, Alfonso; Zora, Marco; D'Anca, Fabio

2015-04-01

The development of new generation of autonomous sea-floor observatories is among the aims of the EC supersite project MARsite (MARMARA Supersite; FP7 EC-funded project, grant n° 308417). An approach based on multiparameter seafloor observatories is considered of basic importance to better understand the role of the fluids in an active tectonic system and their behaviour during the development of the seismogenesis. To continuously collect geochemical and geophysical data from the immediate vicinity of the submerged North Anatolian Fault Zone (NAFZ) is one of the possibilities to contribute to the seismic hazard minimization of the Marmara area. The planning of next generation of seafloor observatories for geo-hazard monitoring is a task in one of the MARsite Work Packages (WP8). The activity is carried out combining together either the experience got after years of investigating fluids and their interactions with the seafloor and tectonic structures and the long-term experience on the development and management of permanent seafloor observatories in the main frame of the EMSO (European Multidisciplinary Seafloor and water-column Observatory, www.emso-eu.org) Research Infrastructure. The new generation of seafloor observatories have to support the observation of both slow and quick variations, thus allow collecting low and high-frequency signals besides the storage of long-term dataset and/or enable the near-real-time mode data transmission. Improvements of some the seafloor equipments have been done so far within MARsite project in terms of the amount of contemporary active instruments, their interlink with "smart sensor" capacities (threshold detection, triggering), quality of the collected data and power consumption reduction. In order to power the multiparameter sensors the digitizer and the microprocessor, an electronic board named PMS (Power Management System) with multi-master, multi-slave, single-ended, serial bus Inter-Integrated Circuit (I²C) interface

Green infrastructure practices – strategies how to sustain life in metropolitan areas

Directory of Open Access Journals (Sweden)

Zaręba Anna

2016-01-01

Full Text Available Green Infrastructure is ‘an interconnected network of green space that conserves natural ecosystem values and functions and provides associated benefits to human populations’ [1, p. 12]. It contributes to long term strategic development goals for data and information management. The research paper was introduced with the aim to protect green areas in urban environment by improving biodiversity, leisure and recreation, tidal and fluvial flood risk management, grey water treatment and quality of life. Planning and design of green system should provide appropriate responses to the distinctive local circumstances. Green spaces encourage social interactions, form new places to practise sport and contribute to public health and fitness, as well as have indirect benefits for a range of environmental services. The research hypothesis is that Green Infrastructure is a framework for conservation and development and we need to design Green Infrastructure systems strategically to connect across urban, suburban, rural and wilderness landscapes and incorporate green space elements and functions at the state, regional, community, neighbourhood and site scales [2]. Analysis and design of emerging Green Infrastructure system take a holistic view which links related physical, environmental, economic, social and cultural aspects of local communities.

U.S. FUEL CYCLE TECHNOLOGIES R&D PROGRAM FOR NEXT GENERATION NUCLEAR MATERIALS MANAGEMENT

Directory of Open Access Journals (Sweden)

M.C. MILLER

2013-11-01

Full Text Available The U.S. Department of Energy's Fuel Cycle Technologies R&D program under the Office of Nuclear Energy is working to advance technologies to enhance both the existing and future fuel cycles. One thrust area is in developing enabling technologies for next generation nuclear materials management under the Materials Protection, Accounting and Control Technologies (MPACT Campaign where advanced instrumentation, analysis and assessment methods, and security approaches are being developed under a framework of Safeguards and Security by Design. An overview of the MPACT campaign's activities and recent accomplishments is presented along with future plans.

The Next Generation of the Montage Image Mopsaic Engine

Science.gov (United States)

Berriman, G. Bruce; Good, John; Rusholme, Ben; Robitaille, Thomas

2016-01-01

We have released a major upgrade of the Montage image mosaic engine (http://montage.ipac.caltech.edu) , as part of a program to develop the next generation of the engine in response to the rapid changes in the data processing landscape in Astronomy, which is generating ever larger data sets in ever more complex formats . The new release (version 4) contains modules dedicated to creating and managing mosaics of data stored as multi-dimensional arrays ("data cubes"). The new release inherits the architectural benefits of portability and scalability of the original design. The code is publicly available on Git Hub and the Montage web page. The release includes a command line tool that supports visualization of large images, and the beta-release of a Python interface to the visualization tool. We will provide examples on how to use these these features. We are generating a mosaic of the Galactic Arecibo L-band Feed Array HI (GALFA-HI) Survey maps of neutral hydrogen in and around our Milky Way Galaxy, to assess the performance at scale and to develop tools and methodologies that will enable scientists inexpert in cloud processing to exploit could platforms for data processing and product generation at scale. Future releases include support for an R-tree based mechanism for fast discovery of and access to large data sets and on-demand access to calibrated SDSS DR9 data that exploits it; support for the Hierarchical Equal Area isoLatitude Pixelization (HEALPix) scheme, now standard for projects investigating cosmic background radiation (Gorski et al 2005); support fort the Tessellated Octahedral Adaptive Subdivision Transform (TOAST), the sky partitioning sky used by the WorldWide Telescope (WWT); and a public applications programming interface (API) in C that can be called from other languages, especially Python.

Next-Generation Sequencing in Neuropathologic Diagnosis of Infections of the Nervous System (Open Access)

Science.gov (United States)

2016-06-13

nervous system ABSTRACT Objective: To determine the feasibility of next-generation sequencing (NGS) microbiome ap- proaches in the diagnosis of infectious...V, van Doorn HR, Nghia HD, et al. Identification of a new cyclovirus in cerebrospinal fluid of patients with acute central nervous system infections...Kumar, et al. system Next-generation sequencing in neuropathologic diagnosis of infections of the nervous This information is current as of June 13

Resilience of Infrastructure Systems to Sea-Level Rise in Coastal Areas: Impacts, Adaptation Measures, and Implementation Challenges

Directory of Open Access Journals (Sweden)

Beatriz Azevedo de Almeida

2016-11-01

Full Text Available Expansive areas of low elevation in many densely populated coastal areas are at elevated risk of storm surges and flooding due to torrential precipitation, as a result of sea level rise. These phenomena could have catastrophic impacts on coastal communities and result in the destruction of critical infrastructure, disruption of economic activities and salt water contamination of the water supply. The objective of the study presented in this paper was to identify various impacts of sea level rise on civil infrastructures in coastal areas and examine the adaptation measures suggested in the existing literature. To this end, a systemic review of the existing literature was conducted in order to identify a repository of studies addressing sea level rise impacts and adaptation measures in the context of infrastructure systems. The study focused on three infrastructure sectors: water and wastewater, energy, and road transportation. The collected information was then analyzed in order to identify different categories of sea level rise impacts and corresponding adaptation measures. The findings of the study are threefold: (1 the major categories of sea level rise impacts on different infrastructure systems; (2 measures for protection, accommodation, and retreat in response to sea level rise impacts; and (3 challenges related to implementing adaptation measures.

Conceptual design of next generation MTR

Energy Technology Data Exchange (ETDEWEB)

Nagata, Hiroshi; Yamaura, Takayuki; Naka, Michihiro; Kawamata, Kazuo; Izumo, Hironobu; Hori, Naohiko; Nagao, Yoshiharu; Kusunoki, Tsuyoshi; Kaminaga, Masanori; Komori, Yoshihiro; Suzuki, Masahide; Kawamura, Hiroshi [Japan Atomic Energy Agency, Oarai Research and Development Center, Oarai, Ibaraki (Japan); Mine, M [Hitachi-GE Nuclear Energy, Ltd., Hitachi, Ibaraki (Japan); Yamazaki, S [Kawasaki Heavy Industries, Ltd., Kobe, Hyogo (Japan); Ishikawa, S [NGK Insulators, Ltd., Nagoya, Aichi (Japan); Miura, K [Sukegawa Electric Co., Ltd., Takahagi, Ibaraki (Japan); Nakashima, S [Fuji Electric Co., Ltd., Tokyo (Japan); Yamaguchi, K [Chiyoda Technol Corp., Tokyo (Japan)

2012-03-15

Conceptual design of the high-performance and low-cost next generation materials testing reactor (MTR) which will be expected to construct in the nuclear power plant introduction countries, started from 2010 in JAEA and nuclear-related companies in Japan. The aims of this conceptual design are to achieve highly safe reactor, economical design, high availability factor and advanced irradiation utilization. One of the basic reactor concept was determined as swimming pool type, thermal power of 10MW and water cooled and moderated reactor with plate type fuel element same as the JMTR. It is expected that the research reactors are used for human resource development, progress of the science and technology, expansion of industry use, lifetime extension of LWRs and so on. (author)

U. S. Fuel Cycle Technologies R and D Program for Next Generation Nuclear Materials Management

International Nuclear Information System (INIS)

Miller, M. C.; Vega, D. A.

2013-01-01

The U. S. Department of Energy's Fuel Cycle Technologies R and D program under the Office of Nuclear Energy is working to advance technologies to enhance both the existing and future fuel cycles. One thrust area is in developing enabling technologies for next generation nuclear materials management under the Materials Protection, Accounting and Control Technologies (MPACT) Campaign where advanced instrumentation, analysis and assessment methods, and security approaches are being developed under a framework of Safeguards and Security by Design. An overview of the MPACT campaign's activities and recent accomplishments is presented along with future plans

WEAVE: the next generation wide-field spectroscopy facility for the William Herschel Telescope : The next generation wide-field spectroscopy facility for the William Herschel Telescope

NARCIS (Netherlands)

Dalton, Gavin; Trager, Scott C.; Abrams, Don Carlos; Carter, David; Bonifacio, Piercarlo; Aguerri, J. Alfonso L.; MacIntosh, Mike; Evans, Chris; Lewis, Ian; Navarro, Ramon; Agocs, Tibor; Dee, Kevin; Rousset, Sophie; Tosh, Ian; Middleton, Kevin; Pragt, Johannes; Terrett, David; Brock, Matthew; Benn, Chris; Verheijen, Marc; Cano Infantes, Diego; Bevil, Craige; Steele, Iain; Mottram, Chris; Bates, Stuart; Gribbin, Francis J.; Rey, Jürg; Rodriguez, Luis Fernando; Delgado, Jose Miguel; Guinouard, Isabelle; Walton, Nic; Irwin, Michael J.; Jagourel, Pascal; Stuik, Remko; Gerlofsma, Gerrit; Roelfsma, Ronald; Skillen, Ian; Ridings, Andy; Balcells, Marc; Daban, Jean-Baptiste; Gouvret, Carole; Venema, Lars; Girard, Paul

We present the preliminary design of the WEAVE next generation spectroscopy facility for the William Herschel Telescope (WHT), principally targeting optical ground-based follow up of upcoming ground-based (LOFAR) and spacebased (Gaia) surveys. WEAVE is a multi-object and multi-IFU facility utilizing

New long-range speed record with next-generation internet

CERN Multimedia

2003-01-01

"Scientists at CERN and the California Institute of Technology have set a new Internet2 land speed record using the next-generation Internet protocol IPv6. The team sustained a single stream Transfer Control Protocol (TCP) rate of 983 megabits per second for more than one hour between CERN and Chicago, a distance of more than 7,000 kilometres" (1 page).

The construction of next-generation matrices for compartmental epidemic models

NARCIS (Netherlands)

Diekmann, O.|info:eu-repo/dai/nl/071896856; Heesterbeek, J.A.P.|info:eu-repo/dai/nl/073321427; Roberts, M.G.

2010-01-01

The basic reproduction number R0 is arguably the most important quantity in infectious disease epidemiology. The next-generation matrix (NGM) is the natural basis for the definition and calculation of R0 where finitely many different categories of individuals are recognized. We clear up confusion

Impact of ectopic pregnancy for reproductive prognosis in next generation

DEFF Research Database (Denmark)

Kårhus, Line Lund; Egerup, Pia; Skovlund, Charlotte Wessel

2014-01-01

The impact of an ectopic pregnancy in the next generation is unknown. Our aim was to compare reproductive outcomes in daughters of women with and without ectopic pregnancy. Designed as a historical prospective controlled cohort study with data collected in four Danish registries from 1977-2009, w...

Tackling investment challenges in power generation - in IEA countries

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

In most IEA countries a new investment cycle in power generation is looming. A window of opportunity now exists to push for a cleaner and more efficient generation portfolio that could transform the power sector and help to build a more sustainable infrastructure lasting over the next 40-50 years. What are the recent trends and prospects for investment in power generation? What are the main drivers and barriers? This book assesses these issues and gives special emphasis to the question of how uncertainties may affect investment decisions. Uncertainties on CO{sub 2} constraints, on power plant licensing, on acceptability of nuclear power, on local opposition to any new energy infrastructure, on government support for specific generation technologies and on government policies on energy efficiency are particularly disturbing. Market liberalisation can also be a key uncertainty, but this may be greatly reduced and deliver considerable benefits if liberalisation is implemented whole-heartedly and backed by on-going government commitment. Government action is urgently needed: to reduce regulatory uncertainty for investors, to establish effective competitive markets and to give firm policy directions in those areas where markets fall short, such as in taking environmental costs and security of supply into account.

INL Human Resource Development and the Next-Generation Safeguards Initiative

Energy Technology Data Exchange (ETDEWEB)

Gouveia, Fernando; Metcalf, Richard Royce Madison

2010-07-01

It is the stated goal of the Next Generation Safeguards Initiative (NGSI) to promote the development of a strengthened nuclear safeguards base, one with the potential to advance the secure and peaceful implementation of nuclear energy world-wide. To meet this goal, the initiative, among other things, has sought to develop a revitalized effort to ensure the continued availability of next generation safeguards professionals. Accordingly, this paper serves to outline the human capital building strategies taken by Idaho National Laboratory (INL) in line with the NGSI. Various components are presented in detail, including INL’s efforts directed at university outreach, in particular the laboratory’s summer internship program, along with the development of various innovative training programs and long-term oriented strategies for student professional development. Special highlights include a video training series, developed by INL in cooperation with LLNL and other laboratories, which sought to expose students and entry-level professionals to the concept and practice of international nuclear safeguards.

Next Generation Workload Management and Analysis System for Big Data

Energy Technology Data Exchange (ETDEWEB)

De, Kaushik [Univ. of Texas, Arlington, TX (United States)

2017-04-24

We report on the activities and accomplishments of a four-year project (a three-year grant followed by a one-year no cost extension) to develop a next generation workload management system for Big Data. The new system is based on the highly successful PanDA software developed for High Energy Physics (HEP) in 2005. PanDA is used by the ATLAS experiment at the Large Hadron Collider (LHC), and the AMS experiment at the space station. The program of work described here was carried out by two teams of developers working collaboratively at Brookhaven National Laboratory (BNL) and the University of Texas at Arlington (UTA). These teams worked closely with the original PanDA team – for the sake of clarity the work of the next generation team will be referred to as the BigPanDA project. Their work has led to the adoption of BigPanDA by the COMPASS experiment at CERN, and many other experiments and science projects worldwide.

NGNP Infrastructure Readiness Assessment: Consolidation Report

International Nuclear Information System (INIS)

Castle, Brian K.

2011-01-01

The Next Generation Nuclear Plant (NGNP) project supports the development, demonstration, and deployment of high temperature gas-cooled reactors (HTGRs). The NGNP project is being reviewed by the Nuclear Energy Advisory Council (NEAC) to provide input to the DOE, who will make a recommendation to the Secretary of Energy, whether or not to continue with Phase 2 of the NGNP project. The NEAC review will be based on, in part, the infrastructure readiness assessment, which is an assessment of industry's current ability to provide specified components for the FOAK NGNP, meet quality assurance requirements, transport components, have the necessary workforce in place, and have the necessary construction capabilities. AREVA and Westinghouse were contracted to perform independent assessments of industry's capabilities because of their experience with nuclear supply chains, which is a result of their experiences with the EPR and AP-1000 reactors. Both vendors produced infrastructure readiness assessment reports that identified key components and categorized these components into three groups based on their ability to be deployed in the FOAK plant. The NGNP project has several programs that are developing key components and capabilities. For these components, the NGNP project have provided input to properly assess the infrastructure readiness for these components.

NGNP Infrastructure Readiness Assessment: Consolidation Report

Energy Technology Data Exchange (ETDEWEB)

Brian K Castle

2011-02-01

The Next Generation Nuclear Plant (NGNP) project supports the development, demonstration, and deployment of high temperature gas-cooled reactors (HTGRs). The NGNP project is being reviewed by the Nuclear Energy Advisory Council (NEAC) to provide input to the DOE, who will make a recommendation to the Secretary of Energy, whether or not to continue with Phase 2 of the NGNP project. The NEAC review will be based on, in part, the infrastructure readiness assessment, which is an assessment of industry's current ability to provide specified components for the FOAK NGNP, meet quality assurance requirements, transport components, have the necessary workforce in place, and have the necessary construction capabilities. AREVA and Westinghouse were contracted to perform independent assessments of industry's capabilities because of their experience with nuclear supply chains, which is a result of their experiences with the EPR and AP-1000 reactors. Both vendors produced infrastructure readiness assessment reports that identified key components and categorized these components into three groups based on their ability to be deployed in the FOAK plant. The NGNP project has several programs that are developing key components and capabilities. For these components, the NGNP project have provided input to properly assess the infrastructure readiness for these components.

Getting to Gender Equality in Energy Infrastructure : Lessons from Electricity Generation, Transmission, and Distribution Projects

OpenAIRE

Orlando, Maria Beatriz; Janik, Vanessa Lopes; Vaidya, Pranav; Angelou, Nicolina; Zumbyte, Ieva; Adams, Norma

2018-01-01

Getting to Gender Equality in Electricity Infrastructure: Lessons from Electricity Generation, Transmission, and Distribution Projects examines the social and gender footprint of large-scale electricity generation, transmission, and distribution projects to establish a foundation on which further research and replication of good practices can be built. The main impact pathways analyzed are...

Addressing Three Common Myths about the Next Generation Science Standards

Science.gov (United States)

Huff, Kenneth L.

2016-01-01

Although the "Next Generation Science Standards" (NGSS Lead States 2013) were released over two years ago, misconceptions about what they are--and are not--persist. The "NGSS" provide for consistent science education opportunities for all students--regardless of demographics--with a level of rigor expected in every location and…

On the use of IT investment assessment methods in the area of spatial data infrastructure

Directory of Open Access Journals (Sweden)

Zwirowicz-Rutkowska Agnieszka

2016-06-01

Full Text Available One of the important issues concerning development of spatial data infrastructures (SDIs is the carrying out of economic and financial analysis. It is essential to determine expenses and also assess effects resulting from the development and use of infrastructures. Costs and benefits assessment could be associated with assessment of the infrastructure effectiveness and efficiency as well as the infrastructure value, understood as the infrastructure impact on economic aspects of an organisational performance, both of an organisation which realises an SDI project and all users of the infrastructure. The aim of this paper is an overview of various assessment methods of investment as well as an analysis of different types of costs and benefits used for information technology (IT projects. Based on the literature, the analysis of the examples of the use of these methods in the area of spatial data infrastructures is also presented. Furthermore, the issues of SDI projects and investments are outlined. The results of the analysis indicate usefulness of the financial methods from different fields of management in the area of SDI building, development and use. The author proposes, in addition to the financial methods, the adaptation of the various techniques used for IT investments and their development, taking into consideration the SDI specificity for the purpose of assessment of different types of costs and benefits and integration of financial aspects with non-financial ones. Among the challenges are identification and quantification of costs and benefits, as well as establishing measures which would fit the characteristics of the SDI project and artefacts resulting from the project realisation. Moreover, aspects of subjectivity and variability in time should be taken into account as the consequences of definite goals and policies as well as business context of organisation undertaking the project or using its artefacts and also investors.

On the use of IT investment assessment methods in the area of spatial data infrastructure

Science.gov (United States)

Zwirowicz-Rutkowska, Agnieszka

2016-06-01

One of the important issues concerning development of spatial data infrastructures (SDIs) is the carrying out of economic and financial analysis. It is essential to determine expenses and also assess effects resulting from the development and use of infrastructures. Costs and benefits assessment could be associated with assessment of the infrastructure effectiveness and efficiency as well as the infrastructure value, understood as the infrastructure impact on economic aspects of an organisational performance, both of an organisation which realises an SDI project and all users of the infrastructure. The aim of this paper is an overview of various assessment methods of investment as well as an analysis of different types of costs and benefits used for information technology (IT) projects. Based on the literature, the analysis of the examples of the use of these methods in the area of spatial data infrastructures is also presented. Furthermore, the issues of SDI projects and investments are outlined. The results of the analysis indicate usefulness of the financial methods from different fields of management in the area of SDI building, development and use. The author proposes, in addition to the financial methods, the adaptation of the various techniques used for IT investments and their development, taking into consideration the SDI specificity for the purpose of assessment of different types of costs and benefits and integration of financial aspects with non-financial ones. Among the challenges are identification and quantification of costs and benefits, as well as establishing measures which would fit the characteristics of the SDI project and artefacts resulting from the project realisation. Moreover, aspects of subjectivity and variability in time should be taken into account as the consequences of definite goals and policies as well as business context of organisation undertaking the project or using its artefacts and also investors.

Next-generation genome-scale models for metabolic engineering

DEFF Research Database (Denmark)

King, Zachary A.; Lloyd, Colton J.; Feist, Adam M.

2015-01-01

Constraint-based reconstruction and analysis (COBRA) methods have become widely used tools for metabolic engineering in both academic and industrial laboratories. By employing a genome-scale in silico representation of the metabolic network of a host organism, COBRA methods can be used to predict...... examples of applying COBRA methods to strain optimization are presented and discussed. Then, an outlook is provided on the next generation of COBRA models and the new types of predictions they will enable for systems metabolic engineering....

Towards next-generation biodiversity assessment using DNA metabarcoding

DEFF Research Database (Denmark)

Taberlet, Pierre; Coissac, Eric; Pompanon, Francois

2012-01-01

Virtually all empirical ecological studies require species identification during data collection. DNA metabarcoding refers to the automated identification of multiple species from a single bulk sample containing entire organisms or from a single environmental sample containing degraded DNA (soil......, water, faeces, etc.). It can be implemented for both modern and ancient environmental samples. The availability of next-generation sequencing platforms and the ecologists need for high-throughput taxon identification have facilitated the emergence of DNA metabarcoding. The potential power of DNA...

JVM: Java Visual Mapping tool for next generation sequencing read.

Science.gov (United States)

Yang, Ye; Liu, Juan

2015-01-01

We developed a program JVM (Java Visual Mapping) for mapping next generation sequencing read to reference sequence. The program is implemented in Java and is designed to deal with millions of short read generated by sequence alignment using the Illumina sequencing technology. It employs seed index strategy and octal encoding operations for sequence alignments. JVM is useful for DNA-Seq, RNA-Seq when dealing with single-end resequencing. JVM is a desktop application, which supports reads capacity from 1 MB to 10 GB.

Development of technology for next generation reactor - Research of evaluation technology for nuclear power plant -

Energy Technology Data Exchange (ETDEWEB)

Park, Jong Kyun; Chang, Moon Heuy; Hwang, Yung Dong [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)] [and others

1993-09-01

For development of next generation reactor, a project for evaluation technology for nuclear power plant is performed. Evaluation technology is essential to next generation reactor for reactor safety and system analysis. For design concept, detailed evaluation technologies are studied as follows: evaluation of safety margin, evaluation of safety facilities, evaluation of measurement and control technology; man-machine interface. Especially for thermal efficiency, thermal properties and chemical composition of inconel 690 tube, instead of inconel 600 tube, are measured for steam generator. (Author).

Next Generation Carbon-Nitrogen Dynamics Model

Science.gov (United States)

Xu, C.; Fisher, R. A.; Vrugt, J. A.; Wullschleger, S. D.; McDowell, N. G.

2012-12-01

Nitrogen is a key regulator of vegetation dynamics, soil carbon release, and terrestrial carbon cycles. Thus, to assess energy impacts on the global carbon cycle and future climates, it is critical that we have a mechanism-based and data-calibrated nitrogen model that simulates nitrogen limitation upon both above and belowground carbon dynamics. In this study, we developed a next generation nitrogen-carbon dynamic model within the NCAR Community Earth System Model (CESM). This next generation nitrogen-carbon dynamic model utilized 1) a mechanistic model of nitrogen limitation on photosynthesis with nitrogen trade-offs among light absorption, electron transport, carboxylation, respiration and storage; 2) an optimal leaf nitrogen model that links soil nitrogen availability and leaf nitrogen content; and 3) an ecosystem demography (ED) model that simulates the growth and light competition of tree cohorts and is currently coupled to CLM. Our three test cases with changes in CO2 concentration, growing temperature and radiation demonstrate the model's ability to predict the impact of altered environmental conditions on nitrogen allocations. Currently, we are testing the model against different datasets including soil fertilization and Free Air CO2 enrichment (FACE) experiments across different forest types. We expect that our calibrated model will considerably improve our understanding and predictability of vegetation-climate interactions.itrogen allocation model evaluations. The figure shows the scatter plots of predicted and measured Vc,max and Jmax scaled to 25 oC (i.e.,Vc,max25 and Jmax25) at elevated CO2 (570 ppm, test case one), reduced radiation in canopy (0.1-0.9 of the radiation at the top of canopy, test case two) and reduced growing temperature (15oC, test case three). The model is first calibrated using control data under ambient CO2 (370 ppm), radiation at the top of the canopy (621 μmol photon/m2/s), the normal growing temperature (30oC). The fitted model

Nuclear Knowledge to the Next Generation

International Nuclear Information System (INIS)

Mazour, Thomas; Kossilov, Andrei

2004-01-01

The safe, reliable, and cost-effective operation of Nuclear Power Plants (NPPs) requires that personnel possess and maintain the requisite knowledge, skills, and attitudes to do their jobs properly. Such knowledge includes not only the technical competencies required by the nature of the technology and particular engineering designs, but also the softer competencies associated with effective management, communication and teamwork. Recent studies have shown that there has been a loss of corporate knowledge and memory. Both explicit knowledge and tacit knowledge must be passed on to the next generation of workers in the industry to ensure a quality workforce. New and different techniques may be required to ensure timely and effective knowledge retention and transfer. The IAEA prepared a report on this subject. The main conclusions from the report regarding strategies for managing the aging workforce are included. Also included are main conclusions from the report regarding the capture an d preservation of mission critical knowledge, and the effective transfer of this knowledge to the next generation of NPP personnel. The nuclear industry due to its need for well-documented procedures, specifications, design basis, safety analyses, etc., has a greater fraction of its mission critical knowledge as explicit knowledge than do many other industries. This facilitates the task of knowledge transfer. For older plants in particular, there may be a need for additional efforts to transfer tacit knowledge to explicit knowledge to support major strategic initiatives such as plant license extensions/renewals, periodic safety reviews, major plant upgrades, and plant specific control room simulator development. The challenge in disseminating explicit knowledge is to make employees aware that it is available and provide easy access in formats and forms that are usable. Tacit knowledge is more difficult to identify and disseminate. The challenge is to identify what can be converted to

Using Digital Watermarking for Securing Next Generation Media Broadcasts

Science.gov (United States)

Birk, Dominik; Gaines, Seán

The Internet presents a problem for the protection of intellectual property. Those who create content must be adequately compensated for the use of their works. Rights agencies who monitor the use of these works exist in many jurisdictions. In the traditional broadcast environment this monitoring is a difficult task. With Internet Protocol Television (IPTV) and Next Generation Networks (NGN) this situation is further complicated.

High Throughput Line-of-Sight MIMO Systems for Next Generation Backhaul Applications

Science.gov (United States)

Song, Xiaohang; Cvetkovski, Darko; Hälsig, Tim; Rave, Wolfgang; Fettweis, Gerhard; Grass, Eckhard; Lankl, Berthold

2017-09-01

The evolution to ultra-dense next generation networks requires a massive increase in throughput and deployment flexibility. Therefore, novel wireless backhaul solutions that can support these demands are needed. In this work we present an approach for a millimeter wave line-of-sight MIMO backhaul design, targeting transmission rates in the order of 100 Gbit/s. We provide theoretical foundations for the concept showcasing its potential, which are confirmed through channel measurements. Furthermore, we provide insights into the system design with respect to antenna array setup, baseband processing, synchronization, and channel equalization. Implementation in a 60 GHz demonstrator setup proves the feasibility of the system concept for high throughput backhauling in next generation networks.

Generation After Next Propulsor Research: Robust Design for Embedded Engine Systems

Science.gov (United States)

Arend, David J.; Tillman, Gregory; O'Brien, Walter F.

2012-01-01

The National Aeronautics and Space Administration, United Technologies Research Center and Virginia Polytechnic and State University have contracted to pursue multi-disciplinary research into boundary layer ingesting (BLI) propulsors for generation after next environmentally responsible subsonic fixed wing aircraft. This Robust Design for Embedded Engine Systems project first conducted a high-level vehicle system study based on a large commercial transport class hybrid wing body aircraft, which determined that a 3 to 5 percent reduction in fuel burn could be achieved over a 7,500 nanometer mission. Both pylon-mounted baseline and BLI propulsion systems were based on a low-pressure-ratio fan (1.35) in an ultra-high-bypass ratio engine (16), consistent with the next generation of advanced commercial turbofans. An optimized, coupled BLI inlet and fan system was subsequently designed to achieve performance targets identified in the system study. The resulting system possesses an inlet with total pressure losses less than 0.5%, and a fan stage with an efficiency debit of less than 1.5 percent relative to the pylon-mounted, clean-inflow baseline. The subject research project has identified tools and methodologies necessary for the design of next-generation, highly-airframe-integrated propulsion systems. These tools will be validated in future large-scale testing of the BLI inlet / fan system in NASA's 8 foot x 6 foot transonic wind tunnel. In addition, fan unsteady response to screen-generated total pressure distortion is being characterized experimentally in a JT15D engine test rig. These data will document engine sensitivities to distortion magnitude and spatial distribution, providing early insight into key physical processes that will control BLI propulsor design.

Electronic health record standards, coding systems, frameworks, and infrastructures

CERN Document Server

Sinha, Pradeep K; Bendale, Prashant; Mantri, Manisha; Dande, Atreya

2013-01-01

Discover How Electronic Health Records Are Built to Drive the Next Generation of Healthcare Delivery The increased role of IT in the healthcare sector has led to the coining of a new phrase ""health informatics,"" which deals with the use of IT for better healthcare services. Health informatics applications often involve maintaining the health records of individuals, in digital form, which is referred to as an Electronic Health Record (EHR). Building and implementing an EHR infrastructure requires an understanding of healthcare standards, coding systems, and frameworks. This book provides an

Looking ahead to our next generation of nurse leaders: Generation X Nurse Managers.

Science.gov (United States)

Keys, Yolanda

2014-01-01

The present inquiry identifies elements of professional success, and personal and professional fulfilment as defined by Generation X Nurse Managers. Although work concerning Nurse Manager preparation has been documented, there is a paucity of research specific to the generation of nurses next in line to assume leadership roles. For the purposes of this study, a qualitative approach was used to develop insight regarding Generation X Nurse Managers and their perspectives on professional success, personal and professional fulfilment, and organisational environments that are conducive to loyalty and long-term professional commitment. Findings from this study reinforced those identified in the original study in that inflexible organisational cultures, a lack of opportunities for upward mobility, the need to be available at all times, feeling stereotyped or undervalued can all be barriers to members of Generation X perceptions of professional success and professional and personal fulfilment. Study findings suggest that Generation X Nurse Managers would benefit from initiatives focused on better preparation for the Nurse Manager role, openness to innovative scheduling alternatives and tailored support and feedback. © 2014 John Wiley & Sons Ltd.

Fetal Kidney Anomalies: Next Generation Sequencing

DEFF Research Database (Denmark)

Rasmussen, Maria; Sunde, Lone; Nielsen, Marlene Louise

Aim and Introduction Identification of abnormal kidneys in the fetus may lead to termination of the pregnancy and raises questions about the underlying cause and recurrence risk in future pregnancies. In this study, we investigate the effectiveness of targeted next generation sequencing in fetuses...... with prenatally detected kidney anomalies in order to uncover genetic explanations and assess recurrence risk. Also, we aim to study the relation between genetic findings and post mortem kidney histology. Methods The study comprises fetuses diagnosed prenatally with bilateral kidney anomalies that have undergone...... postmortem examination. The approximately 110 genes included in the targeted panel were chosen on the basis of their potential involvement in embryonic kidney development, cystic kidney disease, or the renin-angiotensin system. DNA was extracted from fetal tissue samples or cultured chorion villus cells...

Next Generation Nuclear Plant System Requirements Manual

International Nuclear Information System (INIS)

Not Listed

2008-01-01

System Requirements Manual for the NGNP Project. The Energy Policy Act of 2005 (H.R. 6; EPAct), which was signed into law by President George W. Bush in August 2005, required the Secretary of the U.S. Department of Energy (DOE) to establish a project to be known as the Next Generation Nuclear Plant (NGNP) Project. According to the EPAct, the NGNP Project shall consist of the research, development, design, construction, and operation of a prototype plant (to be referred to herein as the NGNP) that (1) includes a nuclear reactor based on the research and development (R and D) activities supported by the Generation IV Nuclear Energy Systems initiative, and (2) shall be used to generate electricity, to produce hydrogen, or to both generate electricity and produce hydrogen. The NGNP Project supports both the national need to develop safe, clean, economical nuclear energy and the Nuclear Hydrogen Initiative (NHI), which has the goal of establishing greenhouse-gas-free technologies for the production of hydrogen. The DOE has selected the helium-cooled High Temperature Gas-Cooled Reactor (HTGR) as the reactor concept to be used for the NGNP because it is the only near-term Generation IV concept that has the capability to provide process heat at high-enough temperatures for highly efficient production of hydrogen. The EPAct also names the Idaho National Laboratory (INL), the DOE's lead national laboratory for nuclear energy research, as the site for the prototype NGNP

NextGEOSS: The Next Generation Data Hub For Earth Observations

Science.gov (United States)

Lilja Bye, Bente; De Lathouwer, Bart; Catarino, Nuno; Concalves, Pedro; Trijssenaar, Nicky; Grosso, Nuno; Meyer-Arnek, Julian; Goor, Erwin

2017-04-01

The Group on Earth observation embarked on the next 10 year phase with an ambition to streamline and further develop its achievements in building the Global Earth Observing System of Systems (GEOSS). The NextGEOSS project evolves the European vision of GEOSS data exploitation for innovation and business, relying on the three main pillars of engaging communities, delivering technological developments and advocating the use of GEOSS, in order to support the creation and deployment of Earth observation based innovative research activities and commercial services. In this presentation we will present the NextGEOSS concept, a concept that revolves around providing the data and resources to the users communities, together with Cloud resources, seamlessly connected to provide an integrated ecosystem for supporting applications. A central component of NextGEOSS is the strong emphasis put on engaging the communities of providers and users, and bridging the space in between.

Super- and Transcritical Fluid Expansions for Next-Generation Energy Conversion Systems

NARCIS (Netherlands)

Harinck, J.

2010-01-01

The next generation of thermodynamic power cycles offers great potential as the conceptual basis for sustainable energy converters. Examples are the supercritical and superheated Organic Rankine cycle, the transcritical condensation cycle, the supercritical Brayton cycle, the Organic Stirling cycle

Energy Efficient Glass Melting - The Next Generation Melter

Energy Technology Data Exchange (ETDEWEB)

David Rue

2008-03-01

The objective of this project is to demonstrate a high intensity glass melter, based on the submerged combustion melting technology. This melter will serve as the melting and homogenization section of a segmented, lower-capital cost, energy-efficient Next Generation Glass Melting System (NGMS). After this project, the melter will be ready to move toward commercial trials for some glasses needing little refining (fiberglass, etc.). For other glasses, a second project Phase or glass industry research is anticipated to develop the fining stage of the NGMS process.

MiSeq: A Next Generation Sequencing Platform for Genomic Analysis.

Science.gov (United States)

Ravi, Rupesh Kanchi; Walton, Kendra; Khosroheidari, Mahdieh

2018-01-01

MiSeq, Illumina's integrated next generation sequencing instrument, uses reversible-terminator sequencing-by-synthesis technology to provide end-to-end sequencing solutions. The MiSeq instrument is one of the smallest benchtop sequencers that can perform onboard cluster generation, amplification, genomic DNA sequencing, and data analysis, including base calling, alignment and variant calling, in a single run. It performs both single- and paired-end runs with adjustable read lengths from 1 × 36 base pairs to 2 × 300 base pairs. A single run can produce output data of up to 15 Gb in as little as 4 h of runtime and can output up to 25 M single reads and 50 M paired-end reads. Thus, MiSeq provides an ideal platform for rapid turnaround time. MiSeq is also a cost-effective tool for various analyses focused on targeted gene sequencing (amplicon sequencing and target enrichment), metagenomics, and gene expression studies. For these reasons, MiSeq has become one of the most widely used next generation sequencing platforms. Here, we provide a protocol to prepare libraries for sequencing using the MiSeq instrument and basic guidelines for analysis of output data from the MiSeq sequencing run.

Answers to Teachers' Questions about the Next Generation Science Standards

Science.gov (United States)

Workosky, Cindy; Willard, Ted

2015-01-01

K-12 teachers of science have been digging into the "Next Generation Science Standards" ("NGSS") (NGSS Lead States 2013) to begin creating plans and processes for translating them for classroom instruction. As teachers learn about the NGSS, they have asked about the general structure of the standards document and how to read…

The Next Generation of Science Standards: Implications for Biology Education

Science.gov (United States)

Bybee, Rodger W.

2012-01-01

The release of A Framework for K-12 Science Education: Practices, Crosscutting Concepts, and Core Ideas (NRC, 2012) provides the basis for the next generation of science standards. This article first describes that foundation for the life sciences; it then presents a draft standard for natural selection and evolution. Finally, there is a…

Process Improvement for Next Generation Space Flight Vehicles: MSFC Lessons Learned

Science.gov (United States)

Housch, Helen

2008-01-01

This viewgraph presentation reviews the lessons learned from process improvement for Next Generation Space Flight Vehicles. The contents include: 1) Organizational profile; 2) Process Improvement History; 3) Appraisal Preparation; 4) The Appraisal Experience; 5) Useful Tools; and 6) Is CMMI working?

Application of next generation sequencing in clinical microbiology and infection prevention

NARCIS (Netherlands)

Deurenberg, Ruud H.; Bathoorn, Erik; Chlebowicz, Monika A.; Couto, Natacha; Ferdous, Mithila; Garcia-Cobos, Silvia; Kooistra-Smid, Anna M. D.; Raangs, Erwin C.; Rosema, Sigrid; Veloo, Alida C. M.; Zhou, Kai; Friedrich, Alexander W.; Rossen, John W. A.

2017-01-01

Current molecular diagnostics of human pathogens provide limited information that is often not sufficient for outbreak and transmission investigation. Next generation sequencing (NGS) determines the DNA sequence of a complete bacterial genome in a single sequence run, and from these data,

Towards the next generation of simplified Dark Matter models

Science.gov (United States)

Albert, Andreas; Bauer, Martin; Brooke, Jim; Buchmueller, Oliver; Cerdeño, David G.; Citron, Matthew; Davies, Gavin; de Cosa, Annapaola; De Roeck, Albert; De Simone, Andrea; Du Pree, Tristan; Flaecher, Henning; Fairbairn, Malcolm; Ellis, John; Grohsjean, Alexander; Hahn, Kristian; Haisch, Ulrich; Harris, Philip C.; Khoze, Valentin V.; Landsberg, Greg; McCabe, Christopher; Penning, Bjoern; Sanz, Veronica; Schwanenberger, Christian; Scott, Pat; Wardle, Nicholas

2017-06-01

This White Paper is an input to the ongoing discussion about the extension and refinement of simplified Dark Matter (DM) models. It is not intended as a comprehensive review of the discussed subjects, but instead summarises ideas and concepts arising from a brainstorming workshop that can be useful when defining the next generation of simplified DM models (SDMM). In this spirit, based on two concrete examples, we show how existing SDMM can be extended to provide a more accurate and comprehensive framework to interpret and characterise collider searches. In the first example we extend the canonical SDMM with a scalar mediator to include mixing with the Higgs boson. We show that this approach not only provides a better description of the underlying kinematic properties that a complete model would possess, but also offers the option of using this more realistic class of scalar mixing models to compare and combine consistently searches based on different experimental signatures. The second example outlines how a new physics signal observed in a visible channel can be connected to DM by extending a simplified model including effective couplings. In the next part of the White Paper we outline other interesting options for SDMM that could be studied in more detail in the future. Finally, we review important aspects of supersymmetric models for DM and use them to propose how to develop more complete SDMMs. This White Paper is a summary of the brainstorming meeting "Next generation of simplified Dark Matter models" that took place at Imperial College, London on May 6, 2016, and corresponding follow-up studies on selected subjects.

DARC: Next generation decentralized control framework for robot applications

DEFF Research Database (Denmark)

Kjærgaard, Morten; Andersen, Nils Axel; Ravn, Ole

2013-01-01

This paper presents DARC, a next generation control framework for robot applications. It is designed to be equally powerful in prototyping research projects and for building serious commercial robots running on low powered embedded hardware, thus closing the gab between research and industry....... It incorporates several new techniques such as a decentralized peer-to-peer architecture, transparent network distribution of the control system, and automatic run-time supervision to guarantee robustness....

Green(ing) infrastructure

CSIR Research Space (South Africa)

Van Wyk, Llewellyn V

2014-03-01

Full Text Available the generation of electricity from renewable sources such as wind, water and solar. Grey infrastructure – In the context of storm water management, grey infrastructure can be thought of as the hard, engineered systems to capture and convey runoff..., pumps, and treatment plants.  Green infrastructure reduces energy demand by reducing the need to collect and transport storm water to a suitable discharge location. In addition, green infrastructure such as green roofs, street trees and increased...

INFRASTRUCTURE

CERN Multimedia

Andrea Gaddi

With all the technical services running, the attention has moved toward the next shutdown that will be spent to perform those modifications needed to enhance the reliability of CMS Infrastructures. Just to give an example for the cooling circuit, a set of re-circulating bypasses will be installed into the TS/CV area to limit the pressure surge when a circuit is partially shut-off. This problem has affected especially the Endcap Muon cooling circuit in the past. Also the ventilation of the UXC55 has to be revisited, allowing the automatic switching to full extraction in case of magnet quench. (Normally 90% of the cavern air is re-circulated by the ventilation system.) Minor modifications will concern the gas distribution, while the DSS action-matrix has to be refined according to the experience gained with operating the detector for a while. On the powering side, some LV power lines have been doubled and the final schematics of the UPS coverage for the counting rooms have been released. The most relevant inte...

Fragility: The Next Wave in Critical Infrastructure Protection

OpenAIRE

Allan McDougall

2009-01-01

In North America today, we are about to embark on a significant effort to repair, or even upgrade, many aspects of our infrastructure. Many of these efforts are linked to economic recovery packages. Others are based on sheer need. The challenge for decision makers and planners involves ensuring that scarce economic resources are put to their best use. Understanding the concept of fragility plays a pivotal part in reaching that understanding.Fragility, like many other systems—particularly Info...

Bringing Next-Generation Sequencing into the Classroom through a Comparison of Molecular Biology Techniques

Science.gov (United States)

Bowling, Bethany; Zimmer, Erin; Pyatt, Robert E.

2014-01-01

Although the development of next-generation (NextGen) sequencing technologies has revolutionized genomic research and medicine, the incorporation of these topics into the classroom is challenging, given an implied high degree of technical complexity. We developed an easy-to-implement, interactive classroom activity investigating the similarities…

Engineered CRISPR Systems for Next Generation Gene Therapies.

Science.gov (United States)

Pineda, Michael; Moghadam, Farzaneh; Ebrahimkhani, Mo R; Kiani, Samira

2017-09-15

An ideal in vivo gene therapy platform provides safe, reprogrammable, and precise strategies which modulate cell and tissue gene regulatory networks with a high temporal and spatial resolution. Clustered regularly interspaced short palindromic repeats (CRISPR), a bacterial adoptive immune system, and its CRISPR-associated protein 9 (Cas9), have gained attention for the ability to target and modify DNA sequences on demand with unprecedented flexibility and precision. The precision and programmability of Cas9 is derived from its complexation with a guide-RNA (gRNA) that is complementary to a desired genomic sequence. CRISPR systems open-up widespread applications including genetic disease modeling, functional screens, and synthetic gene regulation. The plausibility of in vivo genetic engineering using CRISPR has garnered significant traction as a next generation in vivo therapeutic. However, there are hurdles that need to be addressed before CRISPR-based strategies are fully implemented. Some key issues center on the controllability of the CRISPR platform, including minimizing genomic-off target effects and maximizing in vivo gene editing efficiency, in vivo cellular delivery, and spatial-temporal regulation. The modifiable components of CRISPR systems: Cas9 protein, gRNA, delivery platform, and the form of CRISPR system delivered (DNA, RNA, or ribonucleoprotein) have recently been engineered independently to design a better genome engineering toolbox. This review focuses on evaluating CRISPR potential as a next generation in vivo gene therapy platform and discusses bioengineering advancements that can address challenges associated with clinical translation of this emerging technology.

Direct target NOTES: prospective applications for next generation robotic platforms.

Science.gov (United States)

Atallah, S; Hodges, A; Larach, S W

2018-05-01

A new era in surgical robotics has centered on alternative access to anatomic targets and next generation designs include flexible, single-port systems which follow circuitous rather than straight pathways. Such systems maintain a small footprint and could be utilized for specialized operations based on direct organ target natural orifice transluminal endoscopic surgery (NOTES), of which transanal total mesorectal excision (taTME) is an important derivative. During two sessions, four direct target NOTES operations were conducted on a cadaveric model using a flexible robotic system to demonstrate proof-of-concept of the application of a next generation robotic system to specific types of NOTES operations, all of which required removal of a direct target organ through natural orifice access. These four operations were (a) robotic taTME, (b) robotic transvaginal hysterectomy in conjunction with (c) robotic transvaginal salpingo-oophorectomy, and in an ex vivo model, (d) trans-cecal appendectomy. Feasibility was demonstrated in all cases using the Flex ® Robotic System with Colorectal Drive. During taTME, the platform excursion was 17 cm along a non-linear path; operative time was 57 min for the transanal portion of the dissection. Robotic transvaginal hysterectomy was successfully completed in 78 min with transvaginal extraction of the uterus, although laparoscopic assistance was required. Robotic transvaginal unilateral salpingo-oophorectomy with transvaginal extraction of the ovary and fallopian tube was performed without laparoscopic assistance in 13.5 min. In an ex vivo model, a robotic trans-cecal appendectomy was also successfully performed for the purpose of demonstrating proof-of-concept only; this was completed in 24 min. A flexible robotic system has the potential to access anatomy along circuitous paths, making it a suitable platform for direct target NOTES. The conceptual operations posed could be considered suitable for next generation robotics once

The Next Generation Science Standards: A Focus on Physical Science

Science.gov (United States)

Krajcik, Joe

2013-01-01

This article describes ways to adapt U.S. science curriculum to the U.S. National Research Council (NRC) "Framework for K-12 Science Education" and "Next Generation of Science Standards" (NGSS), noting their focus on teaching the physical sciences. The overall goal of the Framework and NGSS is to help all learners develop the…

Research and Development Supporting a Next Generation Germanium Double Beta Decay Experiment

Science.gov (United States)

Rielage, Keith; Elliott, Steve; Chu, Pinghan; Goett, Johnny; Massarczyk, Ralph; Xu, Wenqin

2015-10-01

To improve the search for neutrinoless double beta decay, the next-generation experiments will increase in source mass and continue to reduce backgrounds in the region of interest. A promising technology for the next generation experiment is large arrays of Germanium p-type point contact detectors enriched in 76-Ge. The experience, expertise and lessons learned from the MAJORANA DEMONSTRATOR and GERDA experiments naturally lead to a number of research and development activities that will be useful in guiding a future experiment utilizing Germanium. We will discuss some R&D activities including a hybrid cryostat design, background reduction in cabling, connectors and electronics, and modifications to reduce assembly time. We acknowledge the support of the U.S. Department of Energy through the LANL/LDRD Program.

Beamstrahlung spectra in next generation linear colliders. Revision

Energy Technology Data Exchange (ETDEWEB)

Barklow, T.; Chen, P. [Stanford Linear Accelerator Center, Menlo Park, CA (United States); Kozanecki, W. [DAPNIA-SPP, CEN-Saclay (France)

1992-04-01

For the next generation of linear colliders, the energy loss due to beamstrahlung during the collision of the e{sup +}e{sup {minus}} beams is expected to substantially influence the effective center-of-mass energy distribution of the colliding particles. In this paper, we first derive analytical formulae for the electron and photon energy spectra under multiple beamstrahlung processes, and for the e{sup +}e{sup {minus}} and {gamma}{gamma} differential luminosities. We then apply our formulation to various classes of 500 GeV e{sup +}e{sup {minus}} linear collider designs currently under study.

Semantic e-Learning: Next Generation of e-Learning?

Science.gov (United States)

Konstantinos, Markellos; Penelope, Markellou; Giannis, Koutsonikos; Aglaia, Liopa-Tsakalidi

Semantic e-learning aspires to be the next generation of e-learning, since the understanding of learning materials and knowledge semantics allows their advanced representation, manipulation, sharing, exchange and reuse and ultimately promote efficient online experiences for users. In this context, the paper firstly explores some fundamental Semantic Web technologies and then discusses current and potential applications of these technologies in e-learning domain, namely, Semantic portals, Semantic search, personalization, recommendation systems, social software and Web 2.0 tools. Finally, it highlights future research directions and open issues of the field.

A Survey on 5G: The Next Generation of Mobile Communication

OpenAIRE

Panwar, Nisha; Sharma, Shantanu; Singh, Awadhesh Kumar

2015-01-01

The rapidly increasing number of mobile devices, voluminous data, and higher data rate are pushing to rethink the current generation of the cellular mobile communication. The next or fifth generation (5G) cellular networks are expected to meet high-end requirements. The 5G networks are broadly characterized by three unique features: ubiquitous connectivity, extremely low latency, and very high-speed data transfer. The 5G networks would provide novel architectures and technologies beyond state...

Software R&D for Next Generation of HEP Experiments, Inspired by Theano

CERN Multimedia

CERN. Geneva

2015-01-01

In the next decade, the frontiers of High Energy Physics (HEP) will be explored by three machines: the High Luminosity Large Hadron Collider (HL-LHC) in Europe, the Long Base Neutrino Facility (LBNF) in the US, and the International Linear Collider (ILC) in Japan. These next generation experiments must address two fundamental problems in the current generation of HEP experimental software: the inability to take advantage and adapt to the rapidly evolving processor landscape, and the difficulty in developing and maintaining increasingly complex software systems by physicists. I will propose a strategy, inspired by the automatic optimization and code generation in Theano, to simultaneously address both problems. I will describe three R&D projects with short-term physics deliverables aimed at developing this strategy. The first project is to develop maximally sensitive General Search for New Physics at the LHC by applying the Matrix Element Method running GPUs of HPCs. The second is to classify and reconstru...

SMITH: a LIMS for handling next-generation sequencing workflows

OpenAIRE

Venco, Francesco; Vaskin, Yuriy; Ceol, Arnaud; Muller, Heiko

2014-01-01

Background Life-science laboratories make increasing use of Next Generation Sequencing (NGS) for studying bio-macromolecules and their interactions. Array-based methods for measuring gene expression or protein-DNA interactions are being replaced by RNA-Seq and ChIP-Seq. Sequencing is generally performed by specialized facilities that have to keep track of sequencing requests, trace samples, ensure quality and make data available according to predefined privileges. An integrated tool helps to ...

Benchmark problem suite for reactor physics study of LWR next generation fuels

International Nuclear Information System (INIS)

Yamamoto, Akio; Ikehara, Tadashi; Ito, Takuya; Saji, Etsuro

2002-01-01

This paper proposes a benchmark problem suite for studying the physics of next-generation fuels of light water reactors. The target discharge burnup of the next-generation fuel was set to 70 GWd/t considering the increasing trend in discharge burnup of light water reactor fuels. The UO 2 and MOX fuels are included in the benchmark specifications. The benchmark problem consists of three different geometries: fuel pin cell, PWR fuel assembly and BWR fuel assembly. In the pin cell problem, detailed nuclear characteristics such as burnup dependence of nuclide-wise reactivity were included in the required calculation results to facilitate the study of reactor physics. In the assembly benchmark problems, important parameters for in-core fuel management such as local peaking factors and reactivity coefficients were included in the required results. The benchmark problems provide comprehensive test problems for next-generation light water reactor fuels with extended high burnup. Furthermore, since the pin cell, the PWR assembly and the BWR assembly problems are independent, analyses of the entire benchmark suite is not necessary: e.g., the set of pin cell and PWR fuel assembly problems will be suitable for those in charge of PWR in-core fuel management, and the set of pin cell and BWR fuel assembly problems for those in charge of BWR in-core fuel management. (author)

EDF view on next generation reactor safety and operability issues

International Nuclear Information System (INIS)

Serviere, G.

2002-01-01

is involved at various degrees in the evaluation of next generation: - Light-water reactors; - Gas-cooled reactors; - Liquid-metal reactors. Available information is not the same for all concepts, but nevertheless adequate for identifying areas where confirmation of assumptions would be needed. After discussing some crosscut issues, this paper outlines which areas would have to be clarified for each type of reactor before they could be considered proven by the company. Issues for which R and D programs could be needed are also be identified. (author)

Full C-band Tunable MEMS-VCSEL for Next Generation G.metro Mobile Front- and Backhauling

DEFF Research Database (Denmark)

Wagner, Christoph; Zou, Shihuan Jim; Ortsiefer, Markus

2017-01-01

We report full C-band tunable, 10 Gbit/s capability, directly modulated MEMS-VCSEL for next generation converged mobile fronthaul and backhaul applications. Bit error rates below 10(-9) were achieved over up to 40 km SSMF.......We report full C-band tunable, 10 Gbit/s capability, directly modulated MEMS-VCSEL for next generation converged mobile fronthaul and backhaul applications. Bit error rates below 10(-9) were achieved over up to 40 km SSMF....

The "Next Generation Science Standards" and the Earth and Space Sciences

Science.gov (United States)

Wysession, Michael E.

2013-01-01

The "Next Generation Science Standards" ("NGSS"), due to be released this spring, represents a revolutionary step toward establishing modern, national K-12 science education standards. Based on the recommendations of the National Research Council's "A Framework for K-12 Science Education: Practices, Crosscutting…

A framework for QoS & mobility in the Internet next generation

NARCIS (Netherlands)

Rexhepi, Vlora; Karagiannis, Georgios; Heijenk, Geert; Pras, Aiko

2000-01-01

It is expected that the Internet next generation architecture will support applications with different quality of service requirements, independently of whether their location is fixed or mobile. However, enabling QoS in Internet is a tough challenge, and it gets even tougher when the mobile

A framework for QoS & mobility in the Internet next generation

NARCIS (Netherlands)

Karagiannis, Georgios; Rexhepi, Vlora; Heijenk, Geert

It is expected that the next generation Internet architecture will support applications with different quality of service requirements, independently of whether their location is fixed or movable. However, enabling QoS in Internet is a tough challenge, and it gets even tougher when the mobile

Multi-Stage Admission Control for Load Balancing in Next Generation Systems

DEFF Research Database (Denmark)

Mihovska, Albena D.; Anggorojati, Bayu; Luo, Jijun

2008-01-01

This paper describes a load-dependent multi-stage admission control suitable for next generation systems. The concept uses decision polling in entities located at different levels of the architecture hierarchy and based on the load to activate a sequence of actions related to the admission...

Implementation of defence in depth for next generation light water reactors

International Nuclear Information System (INIS)

1997-12-01

The publication of this IAEA technical document represents the conclusion of a task, initiated in 1995, devoted to defence in depth in future reactors. It focuses mainly on the next generation of LWRs, although many general considerations may also apply to other types of reactors

Priority areas for the formation of innovation infrastructure of the Southern Federal District

Directory of Open Access Journals (Sweden)

M. S. Shiro

2016-01-01

Full Text Available The article analyzes the main trends and particular conditions existing innovation infrastructure in the regions of the Southern Federal District, promotes the commercialization of scientific and educational activities of the sector. It was found that the formation of an effective innovation infrastructure of the region depends on its specificity. In this regard, for the formulation of effective formulas for the construction of the innovation sector of regional economies need to analyze the existing institutions and identify the main points of growth of individual regions. However, in regions concentrated in one federal district it is possible to identify common trends. So the author of the study based on the analysis of these trends come to the conclusion that for all regions is the general low level of development of financial institutions that promote innovation, as well as the weak link between the scientific and educational sphere and the real economy. Summing up the results of the analysis of formation of regional infrastructure, we can conclude that it is currently in the Southern Federal District, Volgograd Region in particular observed the completion of the institutional and infrastructural conditions for the development of innovation. Meanwhile, the existing elements of the innovation infrastructure in the regions characterized by fragmentation and a lack of integration ties, ensuring the implementation of the life cycle of innovation. Particularly acute is the problem of the development of infrastructure of venture financing in science and technology, providing an effective mechanism for technology transfer. To the list of priorities should include the creation of a system of information support of innovation. In order to develop recommendations to strengthen the orientation of research capacity to the needs of the regional economy is necessary to analyze the efficiency of the sector generating knowledge in terms of the

Next generation sequencing of pancreatic ductal adenocarcinoma: right or wrong?

Science.gov (United States)

Connor, Ashton A; Gallinger, Steven

2017-07-01

Pancreatic ductal adenocarcinoma (PDAC) has the highest mortality rate of all epithelial malignancies and a paradoxically rising incidence rate. Clinical translation of next generation sequencing (NGS) of tumour and germline samples may ameliorate outcomes by identifying prognostic and predictive genomic and transcriptomic features in appreciable fractions of patients, facilitating enrolment in biomarker-matched trials. Areas covered: The literature on precision oncology is reviewed. It is found that outcomes may be improved across various malignancies, and it is suggested that current issues of adequate tissue acquisition, turnaround times, analytic expertise and clinical trial accessibility may lessen as experience accrues. Also reviewed are PDAC genomic and transcriptomic NGS studies, emphasizing discoveries of promising biomarkers, though these require validation, and the fraction of patients that will benefit from these outside of the research setting is currently unknown. Expert commentary: Clinical use of NGS with PDAC should be used in investigational contexts in centers with multidisciplinary expertise in cancer sequencing and pancreatic cancer management. Biomarker directed studies will improve our understanding of actionable genomic variation in PDAC, and improve outcomes for this challenging disease.

FDA's Activities Supporting Regulatory Application of "Next Gen" Sequencing Technologies.

Science.gov (United States)

Wilson, Carolyn A; Simonyan, Vahan

2014-01-01

Applications of next-generation sequencing (NGS) technologies require availability and access to an information technology (IT) infrastructure and bioinformatics tools for large amounts of data storage and analyses. The U.S. Food and Drug Administration (FDA) anticipates that the use of NGS data to support regulatory submissions will continue to increase as the scientific and clinical communities become more familiar with the technologies and identify more ways to apply these advanced methods to support development and evaluation of new biomedical products. FDA laboratories are conducting research on different NGS platforms and developing the IT infrastructure and bioinformatics tools needed to enable regulatory evaluation of the technologies and the data sponsors will submit. A High-performance Integrated Virtual Environment, or HIVE, has been launched, and development and refinement continues as a collaborative effort between the FDA and George Washington University to provide the tools to support these needs. The use of a highly parallelized environment facilitated by use of distributed cloud storage and computation has resulted in a platform that is both rapid and responsive to changing scientific needs. The FDA plans to further develop in-house capacity in this area, while also supporting engagement by the external community, by sponsoring an open, public workshop to discuss NGS technologies and data formats standardization, and to promote the adoption of interoperability protocols in September 2014. Next-generation sequencing (NGS) technologies are enabling breakthroughs in how the biomedical community is developing and evaluating medical products. One example is the potential application of this method to the detection and identification of microbial contaminants in biologic products. In order for the U.S. Food and Drug Administration (FDA) to be able to evaluate the utility of this technology, we need to have the information technology infrastructure and

Next Generation Science Partnerships

Science.gov (United States)

Magnusson, J.

2016-02-01

I will provide an overview of the Next Generation Science Standards (NGSS) and demonstrate how scientists and educators can use these standards to strengthen and enhance their collaborations. The NGSS are rich in content and practice and provide all students with an internationally-benchmarked science education. Using these state-led standards to guide outreach efforts can help develop and sustain effective and mutually beneficial teacher-researcher partnerships. Aligning outreach with the three dimensions of the standards can help make research relevant for target audiences by intentionally addressing the science practices, cross-cutting concepts, and disciplinary core ideas of the K-12 science curriculum that drives instruction and assessment. Collaborations between researchers and educators that are based on this science framework are more sustainable because they address the needs of both scientists and educators. Educators are better able to utilize science content that aligns with their curriculum. Scientists who learn about the NGSS can better understand the frameworks under which educators work, which can lead to more extensive and focused outreach with teachers as partners. Based on this model, the International Ocean Discovery Program (IODP) develops its education materials in conjunction with scientists and educators to produce accurate, standards-aligned activities and curriculum-based interactions with researchers. I will highlight examples of IODP's current, successful teacher-researcher collaborations that are intentionally aligned with the NGSS.

Emerging technologies to power next generation mobile electronic devices using solar energy

Institute of Scientific and Technical Information of China (English)

Dewei JIA; Yubo DUAN; Jing LIU

2009-01-01

Mobile electronic devices such as MP3, mobile phones, and wearable or implanted medical devices have already or will soon become a necessity in peoples' lives.However, the further development of these devices is restricted not only by the inconvenient charging process of the power module, but also by the soaring prices of fossil fuel and its downstream chain of electricity manipulation.In view of the huge amount of solar energy fueling the world biochemically and thermally, a carry-on electricity harvester embedded in portable devices is emerging as a most noteworthy research area and engineering practice for a cost efficient solution. Such a parasitic problem is intrinsic in the next generation portable devices. This paper is dedicated to presenting an overview of the photovoltaic strategy in the chain as a reference for researchers and practitioners committed to solving the problem.

Next Generation Nuclear Plant Project Technology Development Roadmaps: The Technical Path Forward

Energy Technology Data Exchange (ETDEWEB)

John Collins

2009-01-01

This document presents the Next Generation Nuclear Plant (NGNP) Systems, Subsystems, and Components, establishes a baseline for the current technology readiness status, and provides a path forward to achieve increasing levels of technical maturity.

Drainage area characterization for evaluating green infrastructure using the Storm Water Management Model

Science.gov (United States)

Lee, Joong Gwang; Nietch, Christopher T.; Panguluri, Srinivas

2018-05-01

Urban stormwater runoff quantity and quality are strongly dependent upon catchment properties. Models are used to simulate the runoff characteristics, but the output from a stormwater management model is dependent on how the catchment area is subdivided and represented as spatial elements. For green infrastructure modeling, we suggest a discretization method that distinguishes directly connected impervious area (DCIA) from the total impervious area (TIA). Pervious buffers, which receive runoff from upgradient impervious areas should also be identified as a separate subset of the entire pervious area (PA). This separation provides an improved model representation of the runoff process. With these criteria in mind, an approach to spatial discretization for projects using the US Environmental Protection Agency's Storm Water Management Model (SWMM) is demonstrated for the Shayler Crossing watershed (SHC), a well-monitored, residential suburban area occupying 100 ha, east of Cincinnati, Ohio. The model relies on a highly resolved spatial database of urban land cover, stormwater drainage features, and topography. To verify the spatial discretization approach, a hypothetical analysis was conducted. Six different representations of a common urbanscape that discharges runoff to a single storm inlet were evaluated with eight 24 h synthetic storms. This analysis allowed us to select a discretization scheme that balances complexity in model setup with presumed accuracy of the output with respect to the most complex discretization option considered. The balanced approach delineates directly and indirectly connected impervious areas (ICIA), buffering pervious area (BPA) receiving impervious runoff, and the other pervious area within a SWMM subcatchment. It performed well at the watershed scale with minimal calibration effort (Nash-Sutcliffe coefficient = 0.852; R2 = 0.871). The approach accommodates the distribution of runoff contributions from different spatial components and

The "Next Generation Science Standards" and the Earth and Space Sciences

Science.gov (United States)

Wysession, Michael E.

2013-01-01

In this article, Michael E. Wysession comments on the "Next Generation Science Standards" (NGSS), which are based on the recommendations of the National Research Council and represent a revolutionary step toward establishing modern, national K-12 science education standards. The NGSS involves significant changes from traditional…

Next Generation Workload Management System For Big Data on Heterogeneous Distributed Computing

International Nuclear Information System (INIS)

Klimentov, A; Maeno, T; Nilsson, P; Panitkin, S; Wenaus, T; Buncic, P; De, K; Oleynik, D; Petrosyan, A; Jha, S; Mount, R; Porter, R J; Read, K F; Wells, J C; Vaniachine, A

2015-01-01

The Large Hadron Collider (LHC), operating at the international CERN Laboratory in Geneva, Switzerland, is leading Big Data driven scientific explorations. Experiments at the LHC explore the fundamental nature of matter and the basic forces that shape our universe, and were recently credited for the discovery of a Higgs boson. ATLAS and ALICE are the largest collaborations ever assembled in the sciences and are at the forefront of research at the LHC. To address an unprecedented multi-petabyte data processing challenge, both experiments rely on a heterogeneous distributed computational infrastructure. The ATLAS experiment uses PanDA (Production and Data Analysis) Workload Management System (WMS) for managing the workflow for all data processing on hundreds of data centers. Through PanDA, ATLAS physicists see a single computing facility that enables rapid scientific breakthroughs for the experiment, even though the data centers are physically scattered all over the world. The scale is demonstrated by the following numbers: PanDA manages O(10 2 ) sites, O(10 5 ) cores, O(10 8 ) jobs per year, O(10 3 ) users, and ATLAS data volume is O(10 17 ) bytes. In 2013 we started an ambitious program to expand PanDA to all available computing resources, including opportunistic use of commercial and academic clouds and Leadership Computing Facilities (LCF). The project titled ‘Next Generation Workload Management and Analysis System for Big Data’ (BigPanDA) is funded by DOE ASCR and HEP. Extending PanDA to clouds and LCF presents new challenges in managing heterogeneity and supporting workflow. The BigPanDA project is underway to setup and tailor PanDA at the Oak Ridge Leadership Computing Facility (OLCF) and at the National Research Center 'Kurchatov Institute' together with ALICE distributed computing and ORNL computing professionals. Our approach to integration of HPC platforms at the OLCF and elsewhere is to reuse, as much as possible, existing components of the

Towards identifying the next generation of superfund and hazardous waste site contaminants

Science.gov (United States)

Ela, Wendell P.; Sedlak, David L.; Barlaz, Morton A.; Henry, Heather F.; Muir, Derek C.G.; Swackhamer, Deborah L.; Weber, Eric J.; Arnold, Robert G.; Ferguson, P. Lee; Field, Jennifer A.; Furlong, Edward T.; Giesy, John P.; Halden, Rolf U.; Henry, Tala; Hites, Ronald A.; Hornbuckle, Keri C.; Howard, Philip H.; Luthy, Richard G.; Meyer, Anita K.; Saez, A. Eduardo; vom Saal, Frederick S.; Vulpe, Chris D.; Wiesner, Mark R.

2011-01-01

Background This commentary evolved from a workshop sponsored by the National Institute of Environmental Health Sciences titled "Superfund Contaminants: The Next Generation" held in Tucson, Arizona, in August 2009. All the authors were workshop participants.

Fiscal Year 2014 Annual Report on BNLs Next Generation Safeguards Initiative Human Capital Development Activities

Energy Technology Data Exchange (ETDEWEB)

Pepper, Susan E. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2014-10-10

Brookhaven National Laboratory’s (BNL’s) Nonproliferation and National Security Department contributes to the National Nuclear Security Administration Office of Nonproliferation and International Security Next Generation Safeguards Initiative (NGSI) through university engagement, safeguards internships, safeguards courses, professional development, recruitment, and other activities aimed at ensuring the next generation of international safeguards professionals is adequately prepared to support the U.S. safeguards mission. This report is a summary of BNL s work under the NGSI program in Fiscal Year 2014.

On the ergodic capacity of legacy systems in the presence of next generation interference

KAUST Repository

Mahmood, Nurul Huda

2011-11-01

Next generation wireless systems facilitating better utilization of the scarce radio spectrum have emerged as a response to inefficient rigid spectrum assignment policies. These are comprised of intelligent radio nodes that opportunistically operate in the radio spectrum of existing legacy systems; yet unwanted interference at the legacy receivers is unavoidable. In order to design efficient next generation systems and to minimize their harmful consequences, it is necessary to realize their impact on the performance of legacy systems. In this work, a generalized framework for the ergodic capacity analysis of such legacy systems in the presence of interference from next generation systems is presented. The analysis is built around a model developed for the statistical representation of the interference at the legacy receivers, which is then used to evaluate the ergodic capacity of the legacy system. Moreover, this analysis is not limited to the context of legacy systems, and is in fact applicaple to any interference limited system. Findings of analytical performance analyses are confirmed through selected computer-based Monte-Carlo simulations. © 2011 IEEE.

Next Generation Campus Network Deployment Project Based on Softswitch

OpenAIRE

HU Feng; LIU Ziyan

2011-01-01

After analyzing the current networks of Guizhou University，we brought forward a scheme of next generation campus networks based on softswitch technology by choosing SoftX3000 switching system of HuaWei and provided the specific solution of accessing campus networks in this paper. It is proved that this scheme is feasible by using OPNET, which not only accomplished the integration of the PSTN and IP networks but also achieved the combining of voice services and data services.

Applying Next Generation Sequencing to Skeletal Development and Disease

OpenAIRE

Bowen, Margot Elizabeth

2013-01-01

Next Generation Sequencing (NGS) technologies have dramatically increased the throughput and lowered the cost of DNA sequencing. In this thesis, I apply these technologies to unresolved questions in skeletal development and disease. Firstly, I use targeted re-sequencing of genomic DNA to identify the genetic cause of the cartilage tumor syndrome, metachondromatosis (MC). I show that the majority of MC patients carry heterozygous loss-of-function mutations in the PTPN11 gene, which encodes a p...

Next Generation Qualification: Nanometrics T120PH Seismometer Evaluation

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Slad, George William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-10-01

Sandia National Laboratories has tested and evaluated three seismometers, the Trillium 120PH, manufactured by Nanometrics. These seismometers measure broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self- noise, dynamic range, and self-calibration ability. The Nanometrics Trillium 120PH seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

Assessment of U.S. Manufacturing Capability for Next-Generation Wind Turbine Drivetrains

Energy Technology Data Exchange (ETDEWEB)

Cotrell, J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Stelhy, T. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

2013-09-01

Robust U.S. wind turbine manufacturing capabilities and supply chains are important for the United States to reduce the cost of electricity generated from wind turbines. These capabilities and supply chains are also critical to the invention and commercialization of new wind turbine technologies while providing high-quality jobs. The development of advanced drivetrain technologies for windturbine applications is advancing the state of the art for drivetrain design by producing higher capacity and operating reliability than conventional drivetrains. Advanced drivetrain technologies such as medium-speed and direct-drive generators, silicon-carbide (SiC) IGBT-based power electronics, and high torque density speed increasers require different manufacturing and supply chaincapabilities that present both risks and opportunities for U.S. wind turbine manufacturers and the wind industry as a whole. The primary objective of this project is to assess how advanced drivetrain technologies and trends will impact U.S. wind turbine manufacturing and its supply chains. The U.S. Department of Energy and other industry participants will use the information from this study toidentify domestic manufacturing gaps, barriers, and opportunities for developing U.S. wind turbine manufacturing capabilities and supply chains for next-generation drivetrain technologies. This report also includes recommendations for prioritizing technology areas for possible investments by public, private, or nonprofit entities that will reduce the cost of wind-generated electricity. Suchinvestments foster opportunities to invent and commercialize new wind turbine technologies, and provide high-quality jobs in the United States.

Power Electronics for the Next Generation Wind Turbine System

DEFF Research Database (Denmark)

Ma, Ke

generation unit, are becoming crucial in the wind turbine system. The objective of this project is to study the power electronics technology used for the next generation wind turbines. Some emerging challenges as well as potentials like the cost of energy and reliability are going to be addressed. First...... conversion is pushed to multi-MW level with high power density requirement. It has also been revealed that thermal stress in the power semiconductors is closely related to many determining factors in the wind power application like the reliability, cost, power density, etc. therefore it is an important......The wind power generation has been steadily growing both for the total installed capacity and for the individual turbine size. Due to much more significant impacts to the power grid, the power electronics, which can change the behavior of wind turbines from an unregulated power source to an active...

Detection of TET2, KRAS and CBL variants by Next Generation ...

African Journals Online (AJOL)

Dilara Fatma Akin

2015-10-01

Oct 1, 2015 ... sarcoma viral oncogene homolog (KRAS), and Casitas B-cell ... AML by screening hot-spot exons of TET2, KRAS, and CBL using Next Generation Sequencing ... Methods: Eight patients who were diagnosed with pediatric AML at Losante ..... mutations in pre-leukemic stem cells in acute myeloid leukemia.

Teaching the "Geo" in Geography with the Next Generation Science Standards

Science.gov (United States)

Wysession, Michael E.

2016-01-01

The Next Generation Science Standards (NGSS; Achieve 2014, 532; Figure 1A) represent a new approach to K-12 science education that involves the interweaving of three educational dimensions: Science and Engineering Practices (SEPs), Disciplinary Core Ideas (DCIs), and Crosscutting Concepts (CCCs). Unlike most preexisting state science standards for…

Next Generation Science Standards: Considerations for Curricula, Assessments, Preparation, and Implementation

Science.gov (United States)

Best, Jane; Dunlap, Allison

2014-01-01

This policy brief provides an overview of the Next Generation Science Standards (NGSS), discusses policy considerations for adopting or adapting the new standards, and presents examples from states considering or implementing the NGSS. Changing academic standards is a complex process that requires significant investments of time, money, and human…

Am I my Family's Keeper? : Disclosure Dilemmas in Next Generation Sequencing

NARCIS (Netherlands)

Wouters, Roel H P; Bijlsma, Rhodé M; Ausems, Margreet G E M; van Delden, Johannes J M; Voest, Emile E; Bredenoord, Annelien L

2016-01-01

Ever since genetic testing is possible for specific mutations, ethical debate has sparked on the question of whether professionals have a duty to warn not only patients but also their relatives that might be at risk for hereditary diseases. As next generation sequencing swiftly finds its way into

Report on the September 2011 Meeting of the Next Generation Safegaurds Professional Network

Energy Technology Data Exchange (ETDEWEB)

Gitau, Ernest TN; Benz, Jacob M.

2011-12-19

The Next Generation Safeguards Professional Network (NGSPN) was established in 2009 by Oak Ridge National Laboratory targeted towards the engagement of young professionals employed in safeguards across the many national laboratories. NGSPN focuses on providing a mechanism for young safeguards professionals to connect and foster professional relationships, facilitating knowledge transfer between current safeguards experts and the next generation of experts, and acting as an entity to represent the interests of the international community of young and mid-career safeguards professionals. This is accomplished in part with a yearly meeting held at a national laboratory site. In 2011, this meeting was held at Pacific Northwest National Laboratory. This report documents the events and results of that meeting.

Diamond Light Source - A Next Generation SR Facility

International Nuclear Information System (INIS)

Materlik, G.

2004-01-01

After the very successful start and the by now almost 10 years operation of the 3rd generation x-ray sources ESRF, APS and Spring-8 smaller storage rings are being planned and constructed with properties emphasising applications with photon energies around the 10 keV spectral region. In the UK the Government and the medical foundation Wellcome Trust have decided to build the Diamond Light Source Facility in the South of Oxfordshire right next to the Rutherford Appleton Laboratory. The joint venture company Diamond Light Source Limited has been created to plan, construct, and operate this facility. (author)

Karect: accurate correction of substitution, insertion and deletion errors for next-generation sequencing data

KAUST Repository

Allam, Amin

2015-07-14

Motivation: Next-generation sequencing generates large amounts of data affected by errors in the form of substitutions, insertions or deletions of bases. Error correction based on the high-coverage information, typically improves de novo assembly. Most existing tools can correct substitution errors only; some support insertions and deletions, but accuracy in many cases is low. Results: We present Karect, a novel error correction technique based on multiple alignment. Our approach supports substitution, insertion and deletion errors. It can handle non-uniform coverage as well as moderately covered areas of the sequenced genome. Experiments with data from Illumina, 454 FLX and Ion Torrent sequencing machines demonstrate that Karect is more accurate than previous methods, both in terms of correcting individual-bases errors (up to 10% increase in accuracy gain) and post de novo assembly quality (up to 10% increase in NGA50). We also introduce an improved framework for evaluating the quality of error correction.

Safety design philosophy of the ABWR for the next generation LWRs

International Nuclear Information System (INIS)

Sato, Takashi; Akinaga, Makoto; Kojima, Yoshihiro

2009-01-01

The paper presents safety design philosophy of the advanced boiling water reactor (ABWR) to be reflected in developing the next generation light water reactors (LWRs). The basic policy of the ABWR safety design was to improve safety and reduce cost simultaneously by reflecting lessons learned of precursors, incidents and accidents that were beyond the design basis such as the Three Mile Island Unit 2 (TMI 2) accident. The ABWR is a fully active safety plant. The ABWR enhanced redundancy and diversity of active safety systems using probabilistic safety assessment (PSA) insights. It adopted a complete three division active emergency core cooling system (ECCS) and attained a very low core damage frequency (CDF) value of less than 10 -7 /ry for internal events. Only very small residual risks, if any, rather exist in external events such as an extremely large earthquake beyond the design basis. This is because external events can constitute a common cause that disables all the redundant active safety systems. Therefore, it is useless to add one more ECCS train and make a four division active ECCS for external events. Nowadays, however, fully passive safety LWRs are already established. Incorporating some of these passive safety systems we can also establish the next generation LWRs that are truly strong against external events. We can establish a plant that can survive a giant earthquake at least three days without AC power source, SA proof safety design that enables no containment failure and no evacuation to eliminate the residual risks. The same basic policy as the ABWR to improve safety and reduce cost simultaneously is again effective for the next generation LWRs. (author)

A Theoretical Secure Enterprise Architecture for Multi Revenue Generating Smart Grid Sub Electric Infrastructure

Science.gov (United States)

Chaudhry, Hina

2013-01-01

This study is a part of the smart grid initiative providing electric vehicle charging infrastructure. It is a refueling structure, an energy generating photovoltaic system and charge point electric vehicle charging station. The system will utilize advanced design and technology allowing electricity to flow from the site's normal electric service…

Molecular Diagnostics in Pathology: Time for a Next-Generation Pathologist?

Science.gov (United States)

Fassan, Matteo

2018-03-01

- Comprehensive molecular investigations of mainstream carcinogenic processes have led to the use of effective molecular targeted agents in most cases of solid tumors in clinical settings. - To update readers regarding the evolving role of the pathologist in the therapeutic decision-making process and the introduction of next-generation technologies into pathology practice. - Current literature on the topic, primarily sourced from the PubMed (National Center for Biotechnology Information, Bethesda, Maryland) database, were reviewed. - Adequate evaluation of cytologic-based and tissue-based predictive diagnostic biomarkers largely depends on both proper pathologic characterization and customized processing of biospecimens. Moreover, increased requests for molecular testing have paralleled the recent, sharp decrease in tumor material to be analyzed-material that currently comprises cytology specimens or, at minimum, small biopsies in most cases of metastatic/advanced disease. Traditional diagnostic pathology has been completely revolutionized by the introduction of next-generation technologies, which provide multigene, targeted mutational profiling, even in the most complex of clinical cases. Combining traditional and molecular knowledge, pathologists integrate the morphological, clinical, and molecular dimensions of a disease, leading to a proper diagnosis and, therefore, the most-appropriate tailored therapy.

Data-Driven Handover Optimization in Next Generation Mobile Communication Networks

Directory of Open Access Journals (Sweden)

Po-Chiang Lin

2016-01-01

Full Text Available Network densification is regarded as one of the important ingredients to increase capacity for next generation mobile communication networks. However, it also leads to mobility problems since users are more likely to hand over to another cell in dense or even ultradense mobile communication networks. Therefore, supporting seamless and robust connectivity through such networks becomes a very important issue. In this paper, we investigate handover (HO optimization in next generation mobile communication networks. We propose a data-driven handover optimization (DHO approach, which aims to mitigate mobility problems including too-late HO, too-early HO, HO to wrong cell, ping-pong HO, and unnecessary HO. The key performance indicator (KPI is defined as the weighted average of the ratios of these mobility problems. The DHO approach collects data from the mobile communication measurement results and provides a model to estimate the relationship between the KPI and features from the collected dataset. Based on the model, the handover parameters, including the handover margin and time-to-trigger, are optimized to minimize the KPI. Simulation results show that the proposed DHO approach could effectively mitigate mobility problems.

Next Generation Nuclear Plant Materials Research and Development Program Plan

Energy Technology Data Exchange (ETDEWEB)

G.O. Hayner; R.L. Bratton; R.N. Wright

2005-09-01

The U.S Department of Energy (DOE) has selected the Very High Temperature Reactor (VHTR) design for the Next Generation Nuclear Plant (NGNP) Project. The NGNP will demonstrate the use of nuclear power for electricity and hydrogen production without greenhouse gas emissions. The reactor design will be a graphite moderated, helium-cooled, prismatic or pebble-bed, thermal neutron spectrum reactor that will produce electricity and hydrogen in a state-of-the-art thermodynamically efficient manner. The NGNP will use very high burn-up, low-enriched uranium, TRISO-coated fuel and have a projected plant design service life of 60 years. The VHTR concept is considered to be the nearest-term reactor design that has the capability to efficiently produce hydrogen. The plant size, reactor thermal power, and core configuration will ensure passive decay heat removal without fuel damage or radioactive material releases during accidents. The NGNP Project is envisioned to demonstrate the following: (1) A full-scale prototype VHTR by about 2021; (2) High-temperature Brayton Cycle electric power production at full scale with a focus on economic performance; (3) Nuclear-assisted production of hydrogen (with about 10% of the heat) with a focus on economic performance; and (4) By test, the exceptional safety capabilities of the advanced gas-cooled reactors. Further, the NGNP program will: (1) Obtain a Nuclear Regulatory Commission (NRC) License to construct and operate the NGNP, this process will provide a basis for future performance based, risk-informed licensing; and (2) Support the development, testing, and prototyping of hydrogen infrastructures. The NGNP Materials Research and Development (R&D) Program is responsible for performing R&D on likely NGNP materials in support of the NGNP design, licensing, and construction activities. The NGNP Materials R&D Program includes the following elements: (1) Developing a specific approach, program plan and other project management tools for

High-performance ferroelectric and magnetoresistive materials for next-generation thermal detector arrays

Science.gov (United States)

Todd, Michael A.; Donohue, Paul P.; Watton, Rex; Williams, Dennis J.; Anthony, Carl J.; Blamire, Mark G.

2002-12-01

This paper discusses the potential thermal imaging performance achievable from thermal detector arrays and concludes that the current generation of thin-film ferroelectric and resistance bolometer based detector arrays are limited by the detector materials used. It is proposed that the next generation of large uncooled focal plane arrays will need to look towards higher performance detector materials - particularly if they aim to approach the fundamental performance limits and compete with cooled photon detector arrays. Two examples of bolometer thin-film materials are described that achieve high performance from operating around phase transitions. The material Lead Scandium Tantalate (PST) has a paraelectric-to-ferroelectric phase transition around room temperature and is used with an applied field in the dielectric bolometer mode for thermal imaging. PST films grown by sputtering and liquid-source CVD have shown merit figures for thermal imaging a factor of 2 to 3 times higher than PZT-based pyroelectric thin films. The material Lanthanum Calcium Manganite (LCMO) has a paramagnetic to ferromagnetic phase transition around -20oC. This paper describes recent measurements of TCR and 1/f noise in pulsed laser-deposited LCMO films on Neodymium Gallate substrates. These results show that LCMO not only has high TCR's - up to 30%/K - but also low 1/f excess noise, with bolometer merit figures at least an order of magnitude higher than Vanadium Oxide, making it ideal for the next generation of microbolometer arrays. These high performance properties come at the expense of processing complexities and novel device designs will need to be introduced to realize the potential of these materials in the next generation of thermal detectors.

NGSUtils: a software suite for analyzing and manipulating next-generation sequencing datasets

OpenAIRE

Breese, Marcus R.; Liu, Yunlong

2013-01-01

Summary: NGSUtils is a suite of software tools for manipulating data common to next-generation sequencing experiments, such as FASTQ, BED and BAM format files. These tools provide a stable and modular platform for data management and analysis.

Design Features and Technology Uncertainties for the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

John M. Ryskamp; Phil Hildebrandt; Osamu Baba; Ron Ballinger; Robert Brodsky; Hans-Wolfgang Chi; Dennis Crutchfield; Herb Estrada; Jeane-Claude Garnier; Gerald Gordon; Richard Hobbins; Dan Keuter; Marilyn Kray; Philippe Martin; Steve Melancon; Christian Simon; Henry Stone; Robert Varrin; Werner von Lensa

2004-06-01

This report presents the conclusions, observations, and recommendations of the Independent Technology Review Group (ITRG) regarding design features and important technology uncertainties associated with very-high-temperature nuclear system concepts for the Next Generation Nuclear Plant (NGNP). The ITRG performed its reviews during the period November 2003 through April 2004.

Next-Generation Bio-Products Sowing the Seeds of Success for Sustainable Agriculture

Directory of Open Access Journals (Sweden)

Henry Müller

2013-10-01

Full Text Available Plants have recently been recognized as meta-organisms due to a close symbiotic relationship with their microbiome. Comparable to humans and other eukaryotic hosts, plants also harbor a “second genome” that fulfills important host functions. These advances were driven by both “omics”-technologies guided by next-generation sequencing and microscopic insights. Additionally, these new results influence applied fields such as biocontrol and stress protection in agriculture, and new tools may impact (i the detection of new bio-resources for biocontrol and plant growth promotion, (ii the optimization of fermentation and formulation processes for biologicals, (iii stabilization of the biocontrol effect under field conditions, and (iv risk assessment studies for biotechnological applications. Examples are presented and discussed for the fields mentioned above, and next-generation bio-products were found as a sustainable alternative for agriculture.

Nucleic acid reactivity : challenges for next-generation semiempirical quantum models

OpenAIRE

Huang, Ming; Giese, Timothy J.; York, Darrin M.

2015-01-01

Semiempirical quantum models are routinely used to study mechanisms of RNA catalysis and phosphoryl transfer reactions using combined quantum mechanical/molecular mechanical methods. Herein, we provide a broad assessment of the performance of existing semiempirical quantum models to describe nucleic acid structure and reactivity in order to quantify their limitations and guide the development of next-generation quantum models with improved accuracy. Neglect of diatomic diffierential overlap (...

NREL Next Generation Drivetrain: Mechanical Design and Test Plan (Poster)

Energy Technology Data Exchange (ETDEWEB)

Keller, J.; Halse, C.

2014-05-01

The Department of Energy and industry partners are sponsoring a $3m project for design and testing of a 'Next Generation' wind turbine drivetrain at the National Renewable Energy Laboratory (NREL). This poster focuses on innovative aspects of the gearbox design, completed as part of an end-to-end systems engineering approach incorporating innovations that increase drivetrain reliability, efficiency, torque density and minimize capital cost.

Next Generation Qualification: Kinemetrics STS-5A Seismometer Evaluation

Energy Technology Data Exchange (ETDEWEB)

Merchant, Bion John [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Slad, George William [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2017-10-01

Sandia National Laboratories has tested and evaluated two seismometers, the STS-5A, manufactured by Kinemetrics. These seismometers measure three axes of broadband ground velocity using a UVW configuration with feedback control in a mechanically levelled borehole package. The purpose of the seismometer evaluation was to determine a measured sensitivity, response, self-noise, dynamic range, and self-calibration ability. The Kinemetrics STS-5A seismometers are being evaluated for the U.S. Air Force as part of their Next Generation Qualification effort.

Estimation of allele frequency and association mapping using next-generation sequencing data

DEFF Research Database (Denmark)

Kim, Su Yeon; Lohmueller, Kirk E; Albrechtsen, Anders

2011-01-01

Estimation of allele frequency is of fundamental importance in population genetic analyses and in association mapping. In most studies using next-generation sequencing, a cost effective approach is to use medium or low-coverage data (e.g., frequency estimation...

Next Generation Agricultural System Data, Models and Knowledge Products: Introduction

Science.gov (United States)

Antle, John M.; Jones, James W.; Rosenzweig, Cynthia E.

2016-01-01

Agricultural system models have become important tools to provide predictive and assessment capability to a growing array of decision-makers in the private and public sectors. Despite ongoing research and model improvements, many of the agricultural models today are direct descendants of research investments initially made 30-40 years ago, and many of the major advances in data, information and communication technology (ICT) of the past decade have not been fully exploited. The purpose of this Special Issue of Agricultural Systems is to lay the foundation for the next generation of agricultural systems data, models and knowledge products. The Special Issue is based on a 'NextGen' study led by the Agricultural Model Intercomparison and Improvement Project (AgMIP) with support from the Bill and Melinda Gates Foundation.

Next-Generation Mitogenomics: A Comparison of Approaches Applied to Caecilian Amphibian Phylogeny

OpenAIRE

Maddock, Simon T.; Briscoe, Andrew G.; Wilkinson, Mark; Waeschenbach, Andrea; San Mauro, Diego; Day, Julia J.; Littlewood, D. Tim J.; Foster, Peter G.; Nussbaum, Ronald A.; Gower, David J.

2016-01-01

Mitochondrial genome (mitogenome) sequences are being generated with increasing speed due to the advances of next-generation sequencing (NGS) technology and associated analytical tools. However, detailed comparisons to explore the utility of alternative NGS approaches applied to the same taxa have not been undertaken. We compared a ‘traditional’ Sanger sequencing method with two NGS approaches (shotgun sequencing and non-indexed, multiplex amplicon sequencing) on four different sequencing pla...

Evaluation Metrics for Intermediate Heat Exchangers for Next Generation Nuclear Reactors

International Nuclear Information System (INIS)

Sabharwall, Piyush; Kim, Eung Soo; Anderson, Nolan

2011-01-01

The Department of Energy (DOE) is working with industry to develop a next generation, high-temperature gas-cooled reactor (HTGR) as a part of the effort to supply the United States with abundant, clean, and secure energy as initiated by the Energy Policy Act of 2005 (EPAct; Public Law 109-58,2005). The NGNP Project, led by the Idaho National Laboratory (INL), will demonstrate the ability of the HTGR to generate hydrogen, electricity, and/or high-quality process heat for a wide range of industrial applications.

Astro Data Science: The Next Generation

Science.gov (United States)

Mentzel, Chris

2018-01-01

Astronomers have been at the forefront of data-driven discovery since before the days of Kepler. Using data in the scientific inquiry into the workings of the the universe is the lifeblood of the field. This said, data science is considered a new thing, and researchers from every discipline are rushing to learn data science techniques, train themselves on data science tools, and even leaving academia to become data scientists. It is undeniable that our ability to harness new computational and statistical methods to make sense of today’s unprecedented size, complexity, and fast streaming data is helping scientists make new discoveries. The question now is how to ensure that researchers can employ these tools and use them appropriately. This talk will cover the state of data science as it relates to scientific research and the role astronomers play in its development, use, and training the next generation of astro-data scientists.

Mutation Detection in Patients with Retinal Dystrophies Using Targeted Next Generation Sequencing

DEFF Research Database (Denmark)

Weisschuh, Nicole; Mayer, Anja K; Strom, Tim M

2016-01-01

Retinal dystrophies (RD) constitute a group of blinding diseases that are characterized by clinical variability and pronounced genetic heterogeneity. The different nonsyndromic and syndromic forms of RD can be attributed to mutations in more than 200 genes. Consequently, next generation sequencing...

A bibliometric analysis of the development of next generation active nanotechnologies

International Nuclear Information System (INIS)

Suominen, Arho; Li, Yin; Youtie, Jan; Shapira, Philip

2016-01-01

Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990–2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.

A bibliometric analysis of the development of next generation active nanotechnologies

Energy Technology Data Exchange (ETDEWEB)

Suominen, Arho [VTT Technical Research Centre of Finland (Finland); Li, Yin; Youtie, Jan, E-mail: jan.youtie@innovate.gatech.edu; Shapira, Philip [Georgia Institute of Technology (United States)

2016-09-15

Delineating the emergence of nanotechnologies that offer new functionalities is an important element in an anticipatory approach to the governance of nanotechnology and its potential impacts. This paper examines the transition to next generation active nanotechnologies which incorporate functions that respond to the environment or systems concepts that combine devices and structures that are dynamic and which may change their states in use. We develop an approach to identifying these active nanotechnologies and then use bibliometric analysis to examine the extent of research papers and patents involving these concepts. We also examine references to environmental, health, and safety concepts in these papers, given that these next generation nanotechnologies are likely to have risk profiles that are different from those of first-generation passive nanomaterials. Our results show a steady growth overall in focus on active nanotechnologies in the research literature and in patents over the study period of 1990–2010. We also find an increase in consideration given to environmental, health, and safety topics. While gaps are highlighted in our understanding of research and innovation in active nanotechnologies, the results suggest that there is beginning to be a shift to active nanotechnologies, with the implication that governance processes need to be conscious of this shift and to prepare for it.

Automotive Radar and Lidar Systems for Next Generation Driver Assistance Functions

Directory of Open Access Journals (Sweden)

R. H. Rasshofer

2005-01-01

Full Text Available Automotive radar and lidar sensors represent key components for next generation driver assistance functions (Jones, 2001. Today, their use is limited to comfort applications in premium segment vehicles although an evolution process towards more safety-oriented functions is taking place. Radar sensors available on the market today suffer from low angular resolution and poor target detection in medium ranges (30 to 60m over azimuth angles larger than ±30°. In contrast, Lidar sensors show large sensitivity towards environmental influences (e.g. snow, fog, dirt. Both sensor technologies today have a rather high cost level, forbidding their wide-spread usage on mass markets. A common approach to overcome individual sensor drawbacks is the employment of data fusion techniques (Bar-Shalom, 2001. Raw data fusion requires a common, standardized data interface to easily integrate a variety of asynchronous sensor data into a fusion network. Moreover, next generation sensors should be able to dynamically adopt to new situations and should have the ability to work in cooperative sensor environments. As vehicular function development today is being shifted more and more towards virtual prototyping, mathematical sensor models should be available. These models should take into account the sensor's functional principle as well as all typical measurement errors generated by the sensor.

Detection of TET2 , KRAS and CBL variants by Next Generation ...

African Journals Online (AJOL)

Aim: In this study, we aimed to find possible genetic markers for molecular analysis in childhood AML by screening hot-spot exons of TET2, KRAS, and CBL using Next Generation Sequencing (NGS) analysis. In addition, association between found variants and mutations of Januse Kinase-2 (JAK2) and Fms Related ...

Addressing Next Generation Science Standards: A Method for Supporting Classroom Teachers

Science.gov (United States)

Pellien, Tamara; Rothenburger, Lisa

2014-01-01

The Next Generation Science Standards (NGSS) will define science education for the foreseeable future, yet many educators struggle to see the bridge between current practice and future practices. The inquiry-based methods used by Extension professionals (Kress, 2006) can serve as a guide for classroom educators. Described herein is a method of…

The next generation of Palapa satellite (Palapa-C)

Science.gov (United States)

Setiawan, Bambang

The Indonesian Palapa Communication Satellite System was established in Aug. 1976 when the first satellite of Palapa A series (Palapa A1) began operation. The system is owned and operated by PT. Telekomunikasi Indonesia (Telkom), which is a state owned company. The purpose of the system was to unify the telecommunications of the nation. Many years of operation have shown that satellite technology is the best solution for improving telecommunications in Indonesia. The system was started with 2 (two) satellites, each with 12 transponders (for a total of 24), and 40 earth stations. Now the system has 3 (three) satellites, each with 24 transponders (for a total of 72 transponders), and thousands of earth stations. The services have been extended to satisfy the requirements of the region as well as the original objectives. The use of satellite transponders in the region is increasing rapidly. In the next ten years, opportunities in the satellite communications business will become even more attractive. The next generation Palapa-C will incorporate improvements in capacity, quality, and coverage. The new frequency bands (ku- and Extended-C Band) will be used to meet the new transponder capacity requirements.

Mineral Potential in India Using Airborne Visible/Infrared Imaging Spectrometer-Next Generation (AVIRIS-NG) Data

Science.gov (United States)

Oommen, T.; Chatterjee, S.

2017-12-01

NASA and the Indian Space Research Organization (ISRO) are generating Earth surface features data using Airborne Visible/Infrared Imaging Spectrometer-Next Generation (AVIRIS-NG) within 380 to 2500 nm spectral range. This research focuses on the utilization of such data to better understand the mineral potential in India and to demonstrate the application of spectral data in rock type discrimination and mapping for mineral exploration by using automated mapping techniques. The primary focus area of this research is the Hutti-Maski greenstone belt, located in Karnataka, India. The AVIRIS-NG data was integrated with field analyzed data (laboratory scaled compositional analysis, mineralogy, and spectral library) to characterize minerals and rock types. An expert system was developed to produce mineral maps from AVIRIS-NG data automatically. The ground truth data from the study areas was obtained from the existing literature and collaborators from India. The Bayesian spectral unmixing algorithm was used in AVIRIS-NG data for endmember selection. The classification maps of the minerals and rock types were developed using support vector machine algorithm. The ground truth data was used to verify the mineral maps.

Next-generation approaches to the microbial ecology of food fermentations

Directory of Open Access Journals (Sweden)

Nicholas A. Bokulich1,2,3 & David A. Mills1,2,3*

2012-07-01

Full Text Available Food fermentations have enhanced human health since the dawnof time and remain a prevalent means of food processing andpreservation. Due to their cultural and nutritional importance,many of these foods have been studied in detail using moleculartools, leading to enhancements in quality and safety. Furthermore,recent advances in high-throughput sequencing technologyare revolutionizing the study of food microbial ecology,deepening insight into complex fermentation systems. Thisreview provides insight into novel applications of selectmolecular techniques, particularly next-generation sequencingtechnology, for analysis of microbial communities in fermentedfoods. We present a guideline for integrated molecular analysis offood microbial ecology and a starting point for implementingnext-generation analysis of food systems.

Methodology on the sparger development for Korean next generation reactor

International Nuclear Information System (INIS)

Kim, Hwan Yeol; Hwang, Y.D.; Kang, H.S.; Cho, B.H.; Park, J.K.

1999-06-01

In case of an accident, the safety depressurization system of Korean Next Generation Reactor (KNGR) efficiently depressurize the reactor pressure by directly discharge steam of high pressure and temperature from the pressurizer into the in-containment refuelling water storage tank (IRWST) through spargers. This report was generated for the purpose of developing the sparger of KNGR. This report presents the methodology on application of ABB-Atom. Many thermal hydraulic parameters affecting the maximum bubble could pressure were obtained and the maximum bubble cloud pressure transient curve so called forcing function of KNGR was suggested and design inputs for IRWST (bubble cloud radius vs. time, bubble cloud velocity vs. time, bubble cloud acceleration vs. time, etc.) were generated by the analytic using Rayleigh-Plesset equation. (author). 17 refs., 6 tabs., 27 figs

Methodology on the sparger development for Korean next generation reactor

Energy Technology Data Exchange (ETDEWEB)

Kim, Hwan Yeol; Hwang, Y.D.; Kang, H.S.; Cho, B.H.; Park, J.K

1999-06-01

In case of an accident, the safety depressurization system of Korean Next Generation Reactor (KNGR) efficiently depressurize the reactor pressure by directly discharge steam of high pressure and temperature from the pressurizer into the in-containment refuelling water storage tank (IRWST) through spargers. This report was generated for the purpose of developing the sparger of KNGR. This report presents the methodology on application of ABB-Atom. Many thermal hydraulic parameters affecting the maximum bubble could pressure were obtained and the maximum bubble cloud pressure transient curve so called forcing function of KNGR was suggested and design inputs for IRWST (bubble cloud radius vs. time, bubble cloud velocity vs. time, bubble cloudacceleration vs. time, etc.) were generated by the analytic using Rayleigh-Plesset equation. (author). 17 refs., 6 tabs., 27 figs.

Interferometric detectors of gravitational waves on Earth: the next generations

Energy Technology Data Exchange (ETDEWEB)

Losurdo, G [INFN Firenze - Via G.Sansone 1, 50019 - Sesto F., Firenze (Italy)], E-mail: losurdo@fi.infn.it

2008-05-15

First generation long-baseline interferometric detectors of gravitational waves are now taking data. A first detection might be possible with these instruments, but more sensitive detectors will be needed to start the field of gravitational wave astronomy. Second generation interferometers will improve the sensitivity by a factor ten, allowing to explore a universe volume 1000 times larger. The technology is almost ready and the construction will start at the beginning of the next decade. The community of the physicists involved in the field has also started to make plans for third generation detectors, for which a long term technology development program will be required. The plans for the upgrades of the existing detectors and the scenario for the evolution of the field will be reviewed in this paper.

Network-Embedded Management and Applications Understanding Programmable Networking Infrastructure

CERN Document Server

Wolter, Ralf

2013-01-01

Despite the explosion of networking services and applications in the past decades, the basic technological underpinnings of the Internet have remained largely unchanged. At its heart are special-purpose appliances that connect us to the digital world, commonly known as switches and routers. Now, however, the traditional framework is being increasingly challenged by new methods that are jostling for a position in the next-generation Internet. The concept of a network that is becoming more programmable is one of the aspects that are taking center stage. This opens new possibilities to embed software applications inside the network itself and to manage networks and communications services with unprecedented ease and efficiency. In this edited volume, distinguished experts take the reader on a tour of different facets of programmable network infrastructure and application exploit it. Presenting the state of the art in network embedded management and applications and programmable network infrastructure, the book c...

Reducing Risk for the Next Generation Nuclear Plant

Energy Technology Data Exchange (ETDEWEB)

John M. Beck II; Harold J. Heydt; Emmanuel O. Opare; Kyle B. Oswald

2010-07-01

The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

Modular EUV Source for the next generation lithography

International Nuclear Information System (INIS)

Sublemontier, O.; Rosset-Kos, M.; Ceccotti, T.; Hergott, J.F.; Auguste, Th.; Normand, D.; Schmidt, M.; Beaumont, F.; Farcage, D.; Cheymol, G.; Le Caro, J.M.; Cormont, Ph.; Mauchien, P.; Thro, P.Y.; Skrzypczak, J.; Muller, S.; Marquis, E.; Barthod, B.; Gaurand, I.; Davenet, M.; Bernard, R.

2011-01-01

The present work, performed in the frame of the EXULITE project, was dedicated to the design and characterization of a laser-plasma-produced extreme ultraviolet (EUV) source prototype at 13.5 nm for the next generation lithography. It was conducted in cooperation with two laboratories from CEA, ALCATEL and THALES. One of our approach originalities was the laser scheme modularity. Six Nd:YAG laser beams were focused at the same time on a xenon filament jet to generate the EUV emitting plasma. Multiplexing has important industrial advantages and led to interesting source performances in terms of in-band power, stability and angular emission properties with the filament jet target. A maximum conversion efficiency (CE) value of 0.44% in 2π sr and 2% bandwidth was measured, which corresponds to a maximum in band EUV mean power of 7.7 W at a repetition rate of 6 kHz. The EUV emission was found to be stable and isotropic in these conditions. (authors)

Reducing Risk for the Next Generation Nuclear Plant

International Nuclear Information System (INIS)

Beck, John M. II; Heydt, Harold J.; Opare, Emmanuel O.; Oswald, Kyle B.

2010-01-01

The Next Generation Nuclear Plant (NGNP) Project, managed by the Idaho National Laboratory (INL), is directed by the Energy Policy Act of 2005, to research, develop, design, construct, and operate a prototype forth generation nuclear reactor to meet the needs of the 21st Century. As with all large projects developing and deploying new technologies, the NGNP has numerous risks that need to be identified, tracked, mitigated, and reduced in order for successful project completion. A Risk Management Plan (RMP) was created to outline the process the INL is using to manage the risks and reduction strategies for the NGNP Project. Integral to the RMP is the development and use of a Risk Management System (RMS). The RMS is a tool that supports management and monitoring of the project risks. The RMS does not only contain a risk register, but other functionality that allows decision makers, engineering staff, and technology researchers to review and monitor the risks as the project matures.

Next generation reactor development activity at Hitachi, Ltd

International Nuclear Information System (INIS)

Yamashita, Junichi

2005-01-01

Developments of innovative nuclear systems in Japan have been highly requested to cope with uncertain future nuclear power generation and fuel cycle situation. Next generation reactor system shall be surely deployed earlier to be capable to provide with several options such as plutonium multi-recycle, intermediate storage of spent fuels, simplified reprocessing of spent fuels and separated storage of 'Pu+FP' and 'U', spent fuels storage after Pu LWR recycle and their combinations, while future reactor system will be targeted at ideal fuel recycle system of higher breeding gain and transmutation of radioactive wastes. Modified designs of the ABWR at large size and medium and small size have been investigated as well as a BWR based RMWR and a supercritical-pressure LWR to ensure safety and improve economics. Advanced fuel cycle technologies of a combination of fluoride volatility process and PUREX process with high decontamination (FLUOREX process) and a modified fluoride volatility process with low decontamination have been developed. (T. Tanaka)

NIRS report of investigations for the development of the next generation PET apparatus. FY 2002

International Nuclear Information System (INIS)

2003-03-01

The present status of studies conducted by representative technology fields for the development of the next generation PET apparatus, and the summary of opinions given by investigators of nuclear medicine are reported. The former involves chapters of: Summary of representative technologies for the development of the next generation PET apparatus; Count rate analysis of PET apparatuses for the whole body and small animals by PET simulator; Scintillator; DOI (depth of interaction) detector-evaluation of the detector with 256-ch fluorescence polarization-photomultiplier tubes (FP-PMT) trial apparatus etc; Examination of multi-slice DOI-MR compatible detector for PET; Development of application specific integrated circuit (ASIC) for processing the front-end signals; Detector simulation; Circuit for processing PET detector signals; Signal processing-coincidence circuit; Data collection system; Signal processing technology for the next generation PET; Reconstruction of statistical PET image using DOI signals; Monte Carlo simulation and Unique directions-PET for infants and for the whole body autonomic nervous systems and mental activity; and Actual design and evaluation of image reconstruction by statistical means. Opinions are: Progress of clinical PET apparatus; Desirable PET drugs and apparatuses; From clinical practice for the development of the next generation PET apparatus; From clinical psychiatric studies for the development; From application of drug development and basic researches; From brain PET practice; From clinical PET practice; and The role of National Institute of Radiological Sciences (NIRS) in PET development. Also involved is the publication list. (N.I.)

Next Generation Computer Resources: Reference Model for Project Support Environments (Version 2.0)

National Research Council Canada - National Science Library

Brown, Alan

1993-01-01

The objective of the Next Generation Computer Resources (NGCR) program is to restructure the Navy's approach to acquisition of standard computing resources to take better advantage of commercial advances and investments...

Design of a fault diagnosis system for next generation nuclear power plants

International Nuclear Information System (INIS)

Zhao, K.; Upadhyaya, B.R.; Wood, R.T.

2004-01-01

A new design approach for fault diagnosis is developed for next generation nuclear power plants. In the nuclear reactor design phase, data reconciliation is used as an efficient tool to determine the measurement requirements to achieve the specified goal of fault diagnosis. In the reactor operation phase, the plant measurements are collected to estimate uncertain model parameters so that a high fidelity model can be obtained for fault diagnosis. The proposed algorithm of fault detection and isolation is able to combine the strength of first principle model based fault diagnosis and the historical data based fault diagnosis. Principal component analysis on the reconciled data is used to develop a statistical model for fault detection. The updating of the principal component model based on the most recent reconciled data is a locally linearized model around the current plant measurements, so that it is applicable to any generic nonlinear systems. The sensor fault diagnosis and process fault diagnosis are decoupled through considering the process fault diagnosis as a parameter estimation problem. The developed approach has been applied to the IRIS helical coil steam generator system to monitor the operational performance of individual steam generators. This approach is general enough to design fault diagnosis systems for the next generation nuclear power plants. (authors)

Technology Advancements in the Next Generation of Domain Agnostic Spatial Data Infrastructures

Science.gov (United States)

Golodoniuc, Pavel; Rankine, Terry; Box, Paul; Atkinson, Rob; Kostanski, Laura

2013-04-01

Spatial Data Infrastructures (SDI) are typically composed of a suite of products focused on improving spatial information discovery and access. Proliferation of SDI initiatives has caused the "Yet Another Portal" (YAP) syndrome to emerge with each initiative providing a new mechanism for cataloguing and enabling users to search for spatial information resources. Often coarse-grained and incomplete metadata information available via these SDIs renders them to being analogous with an antiquated library catalogue. We posit that the successful use of SDI resources requires attention to be focused on various semantic aspects of the information contained within - particularly the information models and vocabularies. Currently it is common for understanding of these models and vocabularies to be built into portals. This does not enhance interoperability between SDIs, nor does this provide a means for referencing or searching for a specific feature (e.g., the City of Sydney) without first knowing the location of the information source for the feature and the form in which it is represented. SDI interfaces, such as OGC WFS, provide data from a spatial representation perspective, but do not provide identifiers that can easily be cited or used across system boundaries. The lack of mechanisms to provide stable identifiers of a feature renders it permanently scoped to a particular dataset. The other three important aspects that are commonly lacking in SDIs are the inadequate handling of feature level metadata that is commonly not sufficient enough for more than the most basic data discovery; features delivered through SDI are not well integrated with information systems that deliver statistical information about those features; and, importantly there are inadequate mechanisms to reconcile and associate multiple identities and representations of the same real world feature. In this paper we present an extended view of an SDI architecture with integrated support for information

Supporting Infrastructure and Acceptability Issues Associated With Two New Generation Vehicles: P2000 and EXS2

Energy Technology Data Exchange (ETDEWEB)

Das, S

2000-06-06

As the Partnership for a New Generation of Vehicles (PNGV) has been proceeding with the development of designs for high-fuel-economy vehicles, it also has been assessing whether impediments exist to the transition to these vehicles. Toward that end, as materials options and vehicle designs have been developed, Oak Ridge National Laboratory (ORNL) has been conducting analyses related to the attendant materials infrastructure requirements. This report addresses the question, what are the infrastructure requirements, acceptance issues, and life-cycle impacts associated with PNGV vehicles constructed of lightweight materials.

Composite Materials under Extreme Radiation and Temperature Environments of the Next Generation Nuclear Reactors

International Nuclear Information System (INIS)

Simos, N.

2011-01-01

In the nuclear energy renaissance, driven by fission reactor concepts utilizing very high temperatures and fast neutron spectra, materials with enhanced performance that exceeds are expected to play a central role. With the operating temperatures of the Generation III reactors bringing the classical reactor materials close to their performance limits there is an urgent need to develop and qualify new alloys and composites. Efforts have been focused on the intricate relations and the high demands placed on materials at the anticipated extreme states within the next generation fusion and fission reactors which combine high radiation fluxes, elevated temperatures and aggressive environments. While nuclear reactors have been in operation for several decades, the structural materials associated with the next generation options need to endure much higher temperatures (1200 C), higher neutron doses (tens of displacements per atom, dpa), and extremely corrosive environments, which are beyond the experience on materials accumulated to-date. The most important consideration is the performance and reliability of structural materials for both in-core and out-of-core functions. While there exists a great body of nuclear materials research and operating experience/performance from fission reactors where epithermal and thermal neutrons interact with materials and alter their physio-mechanical properties, a process that is well understood by now, there are no operating or even experimental facilities that will facilitate the extreme conditions of flux and temperature anticipated and thus provide insights into the behaviour of these well understood materials. Materials, however, still need to be developed and their interaction and damage potential or lifetime to be quantified for the next generation nuclear energy. Based on material development advances, composites, and in particular ceramic composites, seem to inherently possess properties suitable for key functions within the

Technology Innovations from NASA's Next Generation Launch Technology Program

Science.gov (United States)

Cook, Stephen A.; Morris, Charles E. K., Jr.; Tyson, Richard W.

2004-01-01

NASA's Next Generation Launch Technology Program has been on the cutting edge of technology, improving the safety, affordability, and reliability of future space-launch-transportation systems. The array of projects focused on propulsion, airframe, and other vehicle systems. Achievements range from building miniature fuel/oxygen sensors to hot-firings of major rocket-engine systems as well as extreme thermo-mechanical testing of large-scale structures. Results to date have significantly advanced technology readiness for future space-launch systems using either airbreathing or rocket propulsion.

Application of photonics in next generation telecommunication satellites payloads

Science.gov (United States)

Anzalchi, J.; Inigo, P.; Roy, B.

2017-11-01

Next generation broadband telecommunication satellites are required to provide very high data throughput using complex multibeam architectures. These high throughput `Terabit/s' Satellites will incorporate payloads with very large quantity of conventional RF equipment, co-axial cables, waveguides, harnesses and ancillary equipment, making the Assembly, Integration and Test (AIT) very complex. Use of `RF over Fiber' and associated photonics equipment can make the process of AIT much simpler with the added benefit of significant reduction in number of payload equipment and inherent payload mass.

Precision Controlled Carbon Materials for Next-Generation Optoelectronic and Photonic Devices

Science.gov (United States)

2018-01-08

engineer next-generation carbon-based optoelectronic and photonic devices with superior performance and capabilities. These devices include carbon...electronics; (4) nanostructured graphene plasmonics; and (5) polymer-nanotube conjugate chemistry . (1) Semiconducting carbon nanotube-based...applications (In Preparation, 2018). (5) Polymer-nanotube conjugate chemistry Conjugated polymers can be exploited as agents for selectively wrapping and

Compliance uncertainty of diameter characteristic in the next-generation geometrical product specifications and verification

International Nuclear Information System (INIS)

Lu, W L; Jiang, X; Liu, X J; Xu, Z G

2008-01-01

Compliance uncertainty is one of the most important elements in the next-generation geometrical product specifications and verification (GPS). It consists of specification uncertainty, method uncertainty and implementation uncertainty, which are three of the four fundamental uncertainties in the next-generation GPS. This paper analyzes the key factors that influence compliance uncertainty and then proposes a procedure to manage the compliance uncertainty. A general model on evaluation of compliance uncertainty has been devised and a specific formula for diameter characteristic has been derived based on this general model. The case study was conducted and it revealed that the completeness of currently dominant diameter characteristic specification needs to be improved

Next generation platforms for high-throughput bio-dosimetry

International Nuclear Information System (INIS)

Repin, Mikhail; Turner, Helen C.; Garty, Guy; Brenner, David J.

2014-01-01

Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of bio-dosimetry assays was described. These platforms can be used at different stages of bio-dosimetry assays starting from blood collection into micro-tubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multi-well and multichannel plates. Robotically friendly platforms can be used for different bio-dosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems. (authors)

A next generation Ultra-Fast Flash Observatory (UFFO-100) for IR/optical observations of the rise phase of gamma-ray bursts

DEFF Research Database (Denmark)

Grossan, B.; Park, I.H.; Ahmad, S.

2012-01-01

generation of rapid-response space observatory instruments. We list science topics motivating ourinstruments, those that require rapid optical-IR GRB response, including: A survey of GRB rise shapes/times,measurements of optical bulk Lorentz factors, investigation of magnetic dominated (vs. non-magnetic) jet...... for a next generation space observatory as a secondinstrument on a low-earth orbit spacecraft, with a 120 kg instrument mass budget. Restricted to relatively modest mass,power, and launch resources, we find that a coded mask X-ray camera with 1024 cm2 of detector area could rapidlylocate about 64...

Traffic Management for Next Generation Transport Networks

DEFF Research Database (Denmark)

Yu, Hao

required by the next generation transport network to provide Quality-of-Service (QoS) guaranteed video services. Augmenting network capacity and upgrading network nodes indicate long deployment period, replacement of equipment and thus significant cost to the network service providers. This challenge may...... slacken the steps of some network operators towards providing IPTV services. In this dissertation, the topology-based hierarchical scheduling scheme is proposed to tackle the problem addressed. The scheme simplifies the deployment process by placing an intelligent switch with centralized traffic...... management functions at the edge of the network, scheduling traffic on behalf of the other nodes. The topology-based hierarchical scheduling scheme is able to provide outstanding flow isolation due to its centralized scheduling ability, which is essential for providing IPTV services. In order to reduce...

Envisioning the Next Generation of Behavioral Health and Criminal Justice Interventions

Science.gov (United States)

Epperson, Matthew W.; Wolff, Nancy; Morgan, Robert D.; Fisher, William H.; Frueh, B. Christopher; Huening, Jessica