Sample records for ancylostomiasis

  1. Dyspeptic disorders and eosinophilia due to ancylostomiasis:a case report

    Yann A.Meunier


    We present the case of a 41-year old man who consulted for dyspeptic disorders and presented with eosinophilia after a trip to Senegal.The diagnosis of ancylostomiasis was made by a parasitological stool examination.The treatment by fluoromebendazole was successful.

  2. Studies on Ancylostomiasis: 1.An Experimental Study on Hookworm Infection and Anemia

    In view of its prevalence in the Far East area, a more detailed knowledge on the hookworm infection is one of the very important medical problem. The present study was aimed to determine the infectivity of the artificially hatched ancylosotma duodenale larvae in man after its oral administration, evaluate the clinical symptomatology of such infection, determine the date of first appearance of ova in the stool, calculate the blood loss per worm per day, assess the relation-ships between the ova count, infectivity (worm load), blood loss and severity of anemia. An erythrokinetic study was also done to analyse the characteristics of hookworm anemia by means of 59Fe and 51Cr.

  3. Identification, isolation, and molecular cloning of a hookworm protease: an approach towards a defined vaccine for ancylostomiasis

    Hotez, P.J.


    The hookworm Ancylostoma caninum was shown to release in vitro a 37 kDa protease that catalyzed the hydrolysis of fibrinogen, plasminogen, and elastin. The enzyme was purified from parasite extracts by ion-exchange chromatography, followed by gel filtration and hydrophobic interaction chromatography. An amino-terminal sequence was determined. When assayed with radiolabeled fibrin as substrate, the enzyme displayed optimal activity at pH 9-11; it was inactivated by dialysis against ethylenediamine tetraacetic acid. Antiserum raised against the protease in rabbits cross-reacted on western blots with soluble antigen from the infective larval stage of the parasite. A cDNA library from hookworm mRNA was constructed in the expression vector bacteriophage lambdagtll. A positive clone was identified with the rabbit antiserum that was shown to contain an 800-bp insert. The insert was mapped, subcloned into M13, and sequenced, revealing an open reading frame of 789 nucleotides corresponding to 263 amino acids.

  4. Studies on Ancylostomiasis: II.Clinical Symptomatology, Effects of Drugs, especially of Iron Compounds, with Relation to the Severity of Artificial Infection

    Lee, Mun Ho; Kim, Dong Jip; Lee, Jang Kyu; Seo, Byong Sul [Seoul National University College of Medicine, Seoul (Korea, Republic of)


    This study was aimed; firstly to observe various clinical symptomatology with relation to the number of Ancylostoma duodenale larvae orally given to the human beings, secondly to evaluate the effects of some drugs like steroid hormones, antihistaminics and antitussives, and, thirdly to study the influences of some iron compounds in prevention and treatment of anemia of such origin. Ten healthy volunteers free from the previous history of hookworm infection were divided into 4 groups, to whom various numbers of actively moving filariform Ancylostoma duodenale larvae were orally given; 500 to 4 cases, 250 to 3 cases and 100 to 3 cases. Following were the results: 1. Clinical symptomatology. 1) The most frequently encountered symptoms and signs were general malaise, cough and hoarseness. The tracheal itching and pain, low back pain, arthralgia, sputum and salivation, acid belching, loss of appetite, abdominal pain and vomiting were also noted. 2) If the larger number of the larvae was given, the clinical symptomatology was more severe. 3) Prednisolone medication caused some improvement of such symptomatology, while the antihistaminics and antitussives like codeine or ephedrine were ineffective. 4) In volunteers whose nutritional conditions were rather poor appeared to show more severe symptomatology. 2. Effects of iron compounds. 1) The oral administration of ferrous fumarate induced a slight increase of serum iron levels in the initial stage of the infection, then a decrease from 15-20 days later and a recovery after 2 months. 2) The intravenous administration of saccharated ferric oxide induced a steady upkeep of the serum iron levels. 3) The hemoglobin contents also showed the upkeeps after either the oral or intravenous administration of the iron compounds. 4) The iron compounds, therefore, are considered to have the preventive as well as the therapeutic effects on hookworm anemia, which may strongly suggest that hookworm anemia is essentially the iron deficiency type. 3. Hematological changes. 1) The severity of hookworm anemia generally correlated with the number of larvae given. 2) The moderate leucocytosis was observed in all cases regardless of the number of larvae given, which reached to a peak in 25-35 days. 3) Eosinophilia was observed in all cases, but was more severe in cases given larger number of larvae, which was slightly less evident after the medication of prednisolone. 4) Red cell survival time. The red cell survival time determined by {sup 51}Cr was generally in the normal ranges except for the severe anemia patients.

  5. Molecular evidence of shared hookworm Ancylostoma tubaeforme haplotypes between the critically endangered Iberian lynx and sympatric domestic cats

    Millán, J.; Blasco-Costa, Maria Isabel


    Roč. 186, 3-4 (2012), s. 518-522. ISSN 0304-4017 Institutional support: RVO:60077344 Keywords : Ancylostomiasis * Hookworm * Reservoir * Spain Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.381, year: 2012

  6. Výskyt parazitů přenosných na člověka u psa domácího v Evropě.

    Strolená, Eva


    SUMMARY Bachelor thesis on "The incidence of parasites transmibble to human in the dog house in Europe" focuses on the dangers and the latest knowledge of the most common infestations. We consider zoonotic important by alveococ and cystic echinococcosis (hydatiodosis), toxocariasis, leishmaniasis, giardiasis, cryptosporidiosis, ancylostomiasis, taeniosis and external parasites like fleas attack. Most of this work is mainly focused on zoonotic diseases that arise either from direct or indir...

  7. 间接ELISA检测犬钩虫特异性抗体方法的建立

    何光志; 田维毅; 王平; 王文佳; 韩洁; 安永如; 周颖; 简昌友; 崔小东


    @@ 犬钩虫病(ancylostomiasis)是由钩口科钩口属中的犬钩口线虫(又称犬钩虫,Ancylostoma caninum)寄生于犬的肠道主要是十二指肠所引起的一种寄生虫病[1].研究以犬钩虫抗原基因原核表达的重组蛋白为抗原,采用ELISA法检测犬血清中的抗钩虫抗体,以探讨ELISA检测在犬钩虫感染中的应用价值.




    Full Text Available The level of IgE in the serum of singly infected mice (group A, 500 dose; B, 1000 dose; group C, 2000 dose wasstudied during murine ancylostomiasis in all the 3 groups of singly infected animals, IgE level began to decreaseon 1st day of infection, reached the lowest value on day 30 and progressively declined from day 1 to 30 ofexperimental period. Statistical analysis indicated a significant decrease in all the 3 groups when compared withcontrols. These studies demonstrated that the larval antigens provoked an immune response resulting into a lowlevel of serum IgE in the mouse system.

  9. Overview of some biomedical research projects in tropical medicine conducted at the Instituto Venezolano de Investigaciones Cientificas

    Romano Egidio


    Full Text Available The Instituto Venezolano de Investigaciones Cientificas (IVIC is a government-funded multidisciplinary academic institution dedicated to research, development and technology in many areas of knowledge. Biomedical projects and publications comprise about 40% of the total at IVIC. In this article, we present an overview of some selected research and development projects conducted at IVIC which we believe contain new and important aspects related to malaria, ancylostomiasis, dengue fever, leishmaniasis and tuberculosis. Other projects considered of interest in the general area of tropical medicine are briefly described. This article was prepared as a small contribution to honor and commemorate the centenary of the Instituto Oswaldo Cruz.

  10. Hookworm Anemia in a Peritoneal Dialysis Patient in China.

    Wu, Fuquan; Xu, Ying; Xia, Min; Ying, Guanghui; Shou, Zhangfei


    Hookworm infections as well as other intestinal nematodiases are endemic in China. In this case, a 70-year-old male showed symptoms of chest tightness, shortness of breath, and both lower extremities edema. The diagnostic result was chronic renal insufficiency, chronic kidney disease (5th stage), and renal anemia at first. Then, he received treatment with traditional drugs. However, this treatment did not help to alleviate the symptoms of the patient significantly. The results of gastroendoscopy showed hookworms in the duodenum, also confirmed by pathology examination. Anemia was markedly ameliorated after eliminating the parasites. The results mentioned above suggested that ancylostomiasis was the leading causes of anemia in this patient, and the etiology of anemia in uremic patients should be systematically considered. Especially when anemia could not be cured by regular treatments, rare diseases should be investigated. PMID:27417086


    Muhammad Fiaz QAMAR


    Full Text Available Among all animal meats pork is the filthiest diet to consume by human beings. Pig is the cradle of harmful germs. Scientific evidences prove that pig meat is least healthy having different harmful agents like Cholesterol and Fatty Acids, Bacteria and Toxins and a number of parasites. The pig meat is high in fat and cholesterol that causes the cardiovascular diseases, obesity, the incidence of large intestine cancer. Bacteria and Toxins associated with pigs spread many diseases like salmonellosis, which leads to the acute gastroenteritis and diarrhea. Many other diseases like, Tuberculosis, Yersiniosis, Listeriosis, Leptospirosis, Brucellosis, Small Pox, Influenza, Anthrax, Balantidial dysentery, Foot rot, Cholera and Erysipeloid are attributed to pork consumption. Parasitic Diseases Ascaris, Ancylostomiasis, Toxoplasmosis, Trichinellosis, Cysticercosis showing signs of mental disorders, pneumonia, bleeding of the lungs (haemoptysis, which may lead to death or madness. The patient may become blind and deaf. Nitrates used in pork and pork products as additives are converted into nitrosamines which cause hepatic cell tumors. Flesh of the pork is hard to digest and may lead to chronic digestive disturbances. Pimples, boils, cysts are common in pork eaters. The pig excretory system secretes 2 percent of its uric acid that is injurious for the human health. Pork consumption seriously affects human health and adversely injurious one’s moral values. A person gets pig like characteristics by eating pork, Indecency, obscenity and vanished honour of women.

  12. Albendazole, a broad-spectrum anthelmintic, in the treatment of intestinal nematode and cestode infection: a multicenter study in 480 patients.

    Jagota, S C


    The anthelmintic activity of and patient tolerance to albendazole, a broad-spectrum anthelmintic, were studied in a multicenter trial involving 480 patients ranging in age from 2 to 60 years. The patients had single or mixed infections caused by pinworms, roundworms, hookworms, whipworms, threadworms, or tapeworms. The stools were examined by the direct method, and ova were counted by means of the Kato-Katz technique. A Graham-Scotch test was also done in patients infected with Enterobius vermicularis. Most patients received a single 400-mg dose of albendazole; adults were given two tablets, and children were given a 2% suspension. All patients with Hymenolepis nana and about half of those with Taenia infections were treated for three successive days. Patients were carefully evaluated before and after treatment to assess the efficacy and safety of the drug. After a single dose of albendazole, the cure rate was 95.3% in ascariasis, 92.2% in ancylostomiasis, 90.5% in trichuriasis, 64.9% in taeniasis, and 100% in enterobiasis. Among patients receiving 400 mg of albendazole for three days, the cure rate was 63.4% in hymenolepiasis and 86.1% in taeniasis. The drug was well tolerated, and no significant side effects were reported. PMID:3516398

  13. Albendazole in the treatment of intestinal helminthiasis in children.

    Prasad, R; Mathur, P P; Taneja, V K; Jagota, S C


    One hundred sixteen children between 2 and 15 years of age entered a clinical trial of albendazole after examination of their stools revealed ova of one or more intestinal helminths. The drug was administered as a single 400-mg dose (20 ml of 2% suspension) to all the patients except those having Hymenolepis nana infection, who received treatment for three consecutive days. The stools were reexamined on days 7 and 14 posttreatment and after three months for Taenia infections. Patients were considered cured if all parasitological examinations of the feces were negative after treatment. After a single oral dose, albendazole was highly effective in ascariasis (91.9%), ancylostomiasis caused by Ancylostoma duodenale (87.2%), and H nana infection (71.4%). The drug was well tolerated, and no abnormalities were observed in hematological or blood chemistry values. Since the drug is safe and effective as a single-dose treatment of common helminthic infections, it should be considered for mass therapy in the community. PMID:3986860

  14. Vaccination with a cocktail of Ancylostoma ceylanicum recombinant antigens leads to worm burden reduction in hamsters.

    Wiśniewski, Marcin; Łapiński, Maciej; Daniłowicz-Luebert, Emilia; Jaros, Sławomir; Długosz, Ewa; Wędrychowicz, Halina


    Hookworms, a group to which Ancylostoma ceylanicum belongs, are gastrointestinal nematodes that infect more than 700 million people around the world. They are a leading cause of anemia in developing countries. In order to effectively prevent hookworm infections research is conducted to develop an effective vaccine using recombinant antigens of the parasite. The aim of this study was to examine the influence of the hosts' on protection against ancylostomiasis and the shaping of the humoral immune response among Syrian hamsters after immunization with a cocktail of five A. ceylanicum recombinant antigens. Ace-ASP-3, Ace-ASP-4, Ace-APR-1, Ace-MEP-6 and Ace-MEP-7 were obtained in the pET expression system. Immunization with a vaccine cocktail resulted in a 33.5% worm burden reduction. The immunogenicity of the recombinant proteins were determined using ELISA. Statistical analysis showed that vaccinated hamsters developed stronger humoral responses to four of five recombinant antigens (the exception being Ace-ASP-3) compared to hamsters from the control group. PMID:27447220

  15. Hamsters vaccinated with Ace-mep-7 DNA vaccine produced protective immunity against Ancylostoma ceylanicum infection.

    Wiśniewski, Marcin; Jaros, Sławomir; Bąska, Piotr; Cappello, Michael; Długosz, Ewa; Wędrychowicz, Halina


    Hookworms are intestinal nematodes that infect up to 740 million people, mostly in tropical and subtropical regions. Adult worms suck blood from damaged vessels in the gut mucosa, digesting hemoglobin using aspartic-, cysteine- and metalloproteases. Targeting aspartic hemoglobinases using drugs or vaccines is therefore a promising approach to ancylostomiasis control. Based on homology to metalloproteases from other hookworm species, we cloned the Ancylostoma ceylanicum metalloprotease 7 cDNA (Ace-mep-7). The corresponding Ace-MEP-7 protein has a predicted molecular mass of 98.8 kDa. The homology to metallopeptidases from other hookworm species and its predicted transmembrane region support the hypothesis that Ace-MEP-7 may be involved in hemoglobin digestion in the hookworm gastrointestinal tract, especially that our analyses show expression of Ace-mep-7 in the adult stage of the parasite. Immunization of Syrian golden hamsters with Ace-mep-7 cDNA resulted in 50% (p < 0.01) intestinal worm burden reduction. Additionally 78% (p < 0.05) egg count reduction in both sexes was observed. These results suggest that immunization with Ace-mep-7 may contribute to reduction in egg count released into the environment during the A. ceylanicum infection. PMID:26795262

  16. Evaluation of an enzyme-linked immunoelectrotransfer blot test for the confirmatory serodiagnosis of human toxocariasis

    William H Roldán


    Full Text Available To improve the serodiagnosis of human toxocariasis, a sensitive and specific enzyme-linked immunoelectrotransfer blot (EITB-IgG test was developed and evaluated using Toxocara canislarvae excretory-secretory antigens for detecting anti-Toxocara IgG antibodies. The EITB-IgG profile of toxocariasis was characterized by comparing 27 sera from patients with toxocariasis, 110 sera from healthy subjects and 186 sera from patients with other helminth diseases (ascariasis, ancylostomiasis, trichuriasis, enterobiasis, strongyloidiasis, hymenolepiasis, diphyllobothriasis, taeniasis, cysticercosis, hydatidosis and fascioliasis. Antigenic bands of 24, 28, 30, 35, 56, 117, 136 and 152 kDa were predominantly recognized in sera from all patients with toxocariasis. However, only bands of 24-35 kDa were highly specific for Toxocara infection (98.3%, whereas other antigenic bands observed displayed cross-reactivity. Additionally, when the results of the EITB-IgG test were compared to those of the ELISA-IgG test, a 100% concordance was observed for positive results in human toxocariasis cases. The concordance for negative results between the two tests for healthy subjects and patients with other helminth diseases were 96.3% and 53.7%, respectively, showing that the EITB-IgG test has a higher specificity than ELISA. In conclusion, the EITB-IgG test is a very useful tool to confirm the serological diagnosis of human toxocariasis.

  17. Periodic Deworming With Pyrantel For Roundworm And Hookworm Infections In A Farming Village Community.

    Guar S.D


    Full Text Available A farming village community of 512 completed one year of periodic deworming with a single 10 mg/kg oral dose of pyrantel every 3 months. Stool examination by Kato’s thick smear method showed that the prevalence of roundworm infection (ascariasis in the community decreased from 76% to 0%, and that of hookworm infection (ancylostomiasis from 60% to 0%. During the same period the mean hemoglobin increased by 2.3 +/- 0.1 g/dl and the mean body mass index (BMI increased by 0.90 +/- 0.04(P 0.01 for both the drug was tolerated very well as side effects occurred following only 6% of doses (130/2048, and only 1% of these required symptomatic treatment. Quarterly deworming with a single dose of pyrantel is an effective and acceptable method of controlling roundworm and hookworm infections in farming village community having a high prevalence of these worms, and it helps improve the general health of the population to significant degree.


    E. Farahmandian


    Full Text Available The effect of a combination of Oxantel- Pyrantel with a single dose of 10 mg/ kg body weight on Trichuris trichiura, Ascaris, Trichostrongylus spp. and Ancylostoma duodenale has been evaluated among the population of two rural areas in Khuzestan, Southwest Iran (41 persons and Isfahan, Central (30 persons. All patients were infected with Trichuris trichiura and some simultaneously with one or more other helminthes. In addition to stool examinations, to elucidate the possible side- effects, several blood and urine tests were conducted before and after treatment. A cure rate of 83% has been found among Trichuris cases treated in both areas. Cure rates observes for ascariasis and trichostrongyliasis were 93. 3% and 23% in Khuzestan, as well as 90% and 50% in Isfahan, respectively. Cure rate for ancylostomiasis was 86% in Khuzestan.Significant reduction in the mean number of of faeces has been observed.Side- effects encountered were mild and transient. The promisisng effect of this drug on soil – transmitted helminthes, particulary Trichuris trichiura has been proven.

  19. Molecular cloning and analysis of Ancylostoma ceylanicum glutamate-cysteine ligase.

    Wiśniewski, Marcin; Lapiński, Maciej; Zdziarska, Anna; Długosz, Ewa; Bąska, Piotr


    Glutamate-cysteine ligase (GCL) is a heterodimer enzyme composed of a catalytic subunit (GCLC) and a modifier subunit (GCLM). This enzyme catalyses the synthesis of γ-glutamylcysteine, a precursor of glutathione. cDNAs of the putative glutamate-cysteine ligase catalytic (Ace-GCLC) and modifier subunits (Ace-GCLM) of Ancylostoma ceylanicum were cloned using the RACE-PCR amplification method. The Ace-gclc and Ace-gclm cDNAs encode proteins with 655 and 254 amino acids and calculated molecular masses of 74.76 and 28.51kDa, respectively. The Ace-GCLC amino acid sequence shares about 70% identity and 80% sequence similarity with orthologs in Loa loa, Onchocerca volvulus, Brugia malayi, and Ascaris suum, whereas the Ace-GCLM amino acid sequence has only about 30% sequence identity and 50% similarity to homologous proteins in those species. Real-time PCR analysis of mRNA expression in L3, serum stimulated L3 and adult stages of A. ceylanicum showed the highest level of Ace-GCLC and Ace-GCLM expression occurred in adult worms. No differences were detected among adult hookworms harvested 21 and 35dpi indicating expression of Ace-gclc and Ace-gclm in adult worms is constant during the course of infection. Positive interaction between two subunits of glutamate-cysteine ligase was detected using the yeast two-hybrid system, and by specific enzymatic reaction. Ace-GCL is an intracellular enzyme and is not exposed to the host immune system. Thus, as expected, we did not detect IgG antibodies against Ace-GCLC or Ace-GCLM on days 21, 60 and 120 of A. ceylanicum infection in hamsters. Furthermore, vaccination with one or both antigens did not reduce worm burdens, and resulted in no improvement of clinical parameters (hematocrit and hemoglobin) of infected hamsters. Therefore, due to the significant role of the enzyme in parasite metabolism, our analyses raises hope for the development of a successful new drug against ancylostomiasis based on the specific GCL inhibitor. PMID

  20. Surveillance results of soil-transmitted nematode disease in Lingbi County from 2011 to 2013%2011~2013年安徽灵璧县土源性线虫病监测结果分析

    马超; 金伟; 尚军; 刘云章


    Objective To investigate the prevalence and severity of soil-transmitted nematode infec⁃tions in Lingbi County as well as endemic patterns and influencing factors for supplying scientific strategies with prevention and management of this infection. Methods Modified Kato-Katz thick smear technique was used to determine Ascaris lumbricoides, Trichuris trichiura and hookworms from the stool samples(one stool specimen-three slides) collected from 1 000 local villagers of Lingbi County in yearly manner. Other parasite species, if detected, were registered as well. Another 15 soil samples were collected for microscopic examina⁃tion on the presence of tapeworms. Results A total of 3 000 persons were subjected to stool detection from 2011 to 2013. The average infection rate in the 3 years was 13.3%, 7.0%and 6.8%respectively. The infectiosi⁃ty was mild in general, and the infection was primarily involved in ancylostomiasis. The major species found in the soil was Ancylostoma duodenale. Conclusion Lingbi County falls into class 2 endemic area, and the infec⁃tiosity for infected people is generally mild.%目的:了解灵璧县土源性寄生虫病流行现状和感染程度,探索流行规律及影响因素,科学制订防治策略和防治措施。方法每年采用改良加藤厚涂片法(一送三检)对1000名居民的蛔虫、鞭虫和钩虫感染情况进行调查,调查中若发现其它寄生虫感染也一并记录。每年采用镜检方法对15份土壤样本中的钩蚴污染情况进行调查。结果从2011到2013年共调查3000人,3年的感染率分别为13.3%、7.0%和6.8%。感染者主要集中在轻度感染中,且以钩虫感染为主。土壤钩蚴污染以十二指肠钩蚴为主。结论灵璧县属Ⅱ类流行区,感染度以轻度为主。

  1. Association between geohelminth infections and physical growth in schoolchildren Associação entre infecções geohelminticas e crescimento físico de escolares

    Rita de Cássia Ribeiro Silva


    Full Text Available OBJECTIVE: This study aims to assess the association between geohelminth infections and the physical growth of schoolchildren. METHODS: This is a cross-sectional study with the participation of 1861 children aging from 7 to 14 years who live in a municipality in the Southern region (Recôncavo of the State of Bahia. The participants were submitted to anthropometric assessment and stool tests. Multiple logistic regression analysis was used as the statistical means to determine the association of interest. RESULTS: The risks of stunting were greater among boys with Ascaris lumbricoides (Odds ratio=1.79; confidence interval 95%: 1.07-3.01, Trichuris trichiura (Odds ratio=2.26; confidence interval 95%: 1.33-3.84 and ancylostomiasis (Odds ratio=2.18; confidence interval 95%: 1.28-3.73 when compared with non-infected children. These results remained unchanged after adjustments for the location of the school, children's ages and other geohelminth infections. CONCLUSION: These infections did not compromise girls´ growth. These results emphasize the association between geohelminth infection and linear physical growth, indicating the need to implement preventive and curative measures that allow the quality of life of the children to improve since the repercussion that these parasites have on the nutritional status and health of this population is severe.OBJETIVO: Este estudo visa a avaliar a associação entre infecções geohelminticas e o crescimento físico de escolares. MÉTODOS: Trata-se de um estudo de corte transversal em que participaram 1851 indivíduos com idades entre 7 e 14 anos, residentes em um município do Recôncavo Sul do Estado da Bahia. Os indivíduos foram submetidos a avaliação antropométrica e a exame parasitológico de fezes. Utilizou-se a análise de regressão logística múltipla como técnica estatística para avaliar a associação de interesse. RESULTADOS: Os riscos de déficit do crescimento linear foram mais

  2. Relação entre os níveis de vitamina A e os marcadores bioquímicos do estado nutricional de ferro em crianças e adolescentes Relationship between vitamin A and biochemical markers of iron status in children and adolescents

    Rita de Cássia Ribeiro Silva


    positive and statistically significant association was found between the levels of serum retinol and hemoglobin (p=0.007, serum iron (p=0.010 and iron-saturated tranferrin (p=0.027. These findings remained unchanged after adjusting the models for demographic variables, parasitic infections (Schistosoma mansoni, Trichiura trichuris, Ascaris lumbricoides and ancylostomiasis, consumption of bioavailable dietary iron and environmental and home conditions. CONCLUSION: Vitamin A seems to contribute to the increase of organic iron of the population, especially in areas were deficiency of vitamin A and iron-deficiency anemia coexist.

  3. Profilaxia ecológica fitoquímica da Ancilostomose e Estrongiloidose

    Enio Garcia Goulart


    êmicas. Pelas suas características, tais como aceitação popular, pequeno custo operacional e, sobretudo, obtenção de resultados a curto prazo, será altamente oportuno, considerando-se que os recursos convencionais são baseados na educação e engenharia sanitárias, cujos resultados são obtidos a médio e longo prazos e sempre dependentes de cada indivíduo. Além da aplicação médico-sanitária, a presente pesquisa poderá estabelecer possibilidades na profilaxia de certas fitonoses e zoonoses de grande importância econômica na agropecuária.The previously reported activity of natural products of plant origin which inhibit the external larval evolution of Ancylostomidae and of Strongyloides stercoralis, has now been applied in the pratical ecological prophylaxis of human parasitic disease. The study was made in two populations of low economic level inhabiting shanty towns on the Ilha do Governador, Rio de Janeiro, Brasil. During 26 months the following phases were completed: 1 - selection and census ofeach area; 2 - parasitological survey; 3 - mass treatment of both populations with the anthelminthics pyrantel pamoate and thiabendazole, this treatment repeated 10 months later; 4 - introduction of plants with parasitic inhibitory activity in one area, leaving the other as control; 5 - three epidemiological Controls, one after each treatment and then at intervals of 60 to 70 days to determine the prevalence and reinfection leveis of the two parasites in each area. Of the plants introduced only lemon-grass, Cymbopogon citratus, survived and attained an average density of one dump per 10 m². Ancylostomiasis levels fell in the plantedarea from 23.2% to 2.2% and in the control are from 14.5% to 5.8% during the twenty-one month study. Strongyloidiasis fell from 17.1% to 0.6% in the planted area, and from 13% to 2.9% in the control area. 46% of the initially examined populations were followed through to the end. The reduction in prevalence of hookworms, 30.5% higher in

  4. Analysis on the epidemiological situation of soil-transmitted nematode infections at the monitoring spot of Chongqing from 2006 to 2010%重庆市2006—2010年土源性线虫病国家级监测点监测分析

    谢君; 吴成果; 罗飞; 蒋诗国; 李珊珊


    Objective To understand infection status and epidemic law of soil-transmitted nematode infections in Chongqing.Methods The stool samples of the residents at monitoring spot of Chongqing were collected and examined for Ascaris lumbricoides,Trichuris trichiura and hookworms with modified Kato-Katz thick smear "one stool specimen-three slides" from September to November during 2006-2010,and adhesive cellophane anal swab method was applied additionally for examining the eggs of Enterobius vermicularis in children aged 3-12.Ten soil samples were collected for microscopic examination on fertilized or unfertilized Ascaris eggs and the living ability of fertilized Ascaris eggs was determined.Results The total of 5 071 persons were investigated from 2006 to 2010 and the annual infection rates were 5.79%,13.52%,16.63%,8.62%and 2.81% showing a declined tendency (x2=3.65,P < 0.01).The infection rates of females were higher than males in 2007 and 2008 (x2=4.66,P < 0.05;x2 =25.29,P < 0.01).The infection rate of 5-year-old was in the highest level in 2006 and 2010.In 2010 the infection rate of 50-year-old was in the highest level.The ancylostomiasis and Ascaris were the major soil transmitted nematode diseases.The infection rates of Enterobius vermicularis were not significantly different between boys and girls.It showed a declined tendency in pinworm infection in girls(x2=16.36,P < 0.01)while it showed no difference in boys(x2=8.45,P > 0.05).The positive rates of Ascaris eggs in soil samples were 52.5%,37.5%,17.5%,30.0% and 20.0% showing a declined tendency (x2 =16.36,P < 0.01).Conclusion According to the 5 years monitoring,the infection rate of soil-transmitted nematodes was declined,but health education and mass chemotherapy should be enhanced continuously.%目的 掌握重庆市土源性线虫病流行动态和流行规律.方法 2006-2010年,每年9-12月在重庆市监测点采集年龄3周岁以上的全体常驻居民粪便,采用改良加

  5. 安徽省2006-2010年土源性线虫病国家级监测点监测分析%Analysis on the epidemiological situation of soil-transmitted nematode infections at the national monitoring spots of Anhui Province, 2006-2010

    郭见多; 金伟; 朱磊; 方国仁; 姚光秀; 尹晓梅; 周莉; 罗俊平; 李启扬


    pattern comparing the infection rates between males and females.The infection rate rapidly decreased in teenagers especially in the age group between 15 to 19 years and decreased from 20.59% to 0 in this age group during the 5 years.However,the infection rate maintained a higher level in age group above 50-year-old.Ancylostomiasis was the major soil transmitted nematode disease.The detection rates of Ascaris eggs in the soil correlated with the infection rates.Conclusion According to the 5 years monitoring,the infection rate of soil-transmitted nematodes was declining indicating the necessity of continuous monitoring.