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1

Effects of smoking on resorption of the residual alveolar ridges in complete denture wearers  

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Full Text Available Introduction Based on literature data it is obvious that there is a connection between smoking and periodontal diseases. Alveolar bone loss increases with smoking. Tobacco smoking affects the proportion of subgingival bacterial flora by influencing oxidoreduction potential of dental plaque and thus making conditions for development of anaerobic bacteria. According to some researchers, smoking affects the mineral component of bone tissue. Orthopantomograms show higher level of alveolar bone loss in smokers than in nonsmokers with the same level of oral hygiene. The aim of this study was to establish if smoking affects alveolar bone loss in complete denture wearers. Material and methods Our clinical investigation included 60 patients of both sexes (30 smokers and 30 nonsmokers all complete dentures wearers. All patients met study criteria: jaw relation and smokers who smoke over 20 cigarettes per day. All subjects were interviewed, and after that orthopantomograms were made. They were used to calculate the degree of alveolar bone loss. Results The examined subjects were approximately of the same age. Mean age of smokers was 59.9 and nonsmokers 61.8. It was established that differences regarding resorption in men were not significant. The degree of resorption in women smokers and women nonsmokers was different, but differences were not significant. Discussion It has been proven that the number of cigarettes smoked per day is very important. It is considered that the risk of oral epithelial dysplasia increases when smoking more than 20 cigarettes per day. Considering our results regarding resorption of edentulous alveolar ridge in smokers and nonsmokers, we concluded that there were no significant differences. There are opinions in literature that smoking is not an etiological factor in resorption, but there are some opinions that smoking is connected with the degree of resorption in periodontium. The analyses of resorptive changes in edentulous smokers were done only around implants and it was estimated that smoking has more influence than other clinical risk factors. Conclusion On the bases of our research we may conclude that smoking does not directly affect the degree of resorption of edentulous alveolar ridge with complete denture wearers.

Markovi? Dubravka

2003-01-01

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The role of synthetic biomaterials in resorptive alveolar bone regeneration  

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Full Text Available The alveolar bone tissue resorption defect has a significant role in dentistry. Because of the bone tissue deficit developed by alveolar resorption, the use of synthetic material CP/PLGA (calcium-phosphate/polylactide-co-gliycolide composite was introduced. Investigations were performed on rats with artificially produced resorption of the mandibular bone. The results show that the best effect on alveolar bone were attained by using nano-composite implants. The effect of the nanocomposite was ascertained by determining the calcium and phosphate content, as a basis of the hydroxyapatite structure. The results show that synthetic CP/PLGA nanocomposite alleviate the rehabilitation of weakened alveolar bone. Due to its osteoconductive effect, CP/PLGA can be the material of choice for bone substitution in the future.

Kali?anin Biljana M.

2007-01-01

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Alveolar ridge augmentation in irradiated rabbit mandibles.  

Science.gov (United States)

Oral carcinomas are frequently treated with a nonsegmental mandibulectomy plus radiotherapy. Improving the quality of life of these patients depends on the possibilities for dental rehabilitation. The aim of this study was to increase the alveolar ridge height. Twelve white New Zealand rabbits underwent surgery to produce a 11 x 9 x 7 mm(3) horizontal bicortical full-thickness defect at the alveolar ridge of the left mandible. Six were implanted with a composite associating resorbable collagen membrane filled with micro-macroporous biphasic calcium phosphate granules. After a daily radiation delivery schedule for 4 weeks, a total autologous bone marrow graft was injected percutaneously into the center of the implant. All animals were sacrificed at 16 weeks. Successful osseous colonization was observed in all implants. Significant ridge augmentation was observed (p = 0.0349) in the implanted group compared with the control group. This study contributed to producing an experimental model for oncological mandible defects in rabbits. PMID:20014287

Jegoux, Franck; Aguado, Eric; Cognet, Ronan; Malard, Olivier; Moreau, Françoise; Daculsi, Guy; Goyenvalle, Eric

2010-06-15

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Macrophage depletion abates Porphyromonas gingivalis-induced alveolar bone resorption in mice.  

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The role of the macrophage in the immunopathology of periodontitis has not been well defined. In this study, we show that intraoral inoculation of mice with Porphyromonas gingivalis resulted in infection, alveolar bone resorption, and a significant increase in F4/80(+) macrophages in gingival and submandibular lymph node tissues. Macrophage depletion using clodronate-liposomes resulted in a significant reduction in F4/80(+) macrophage infiltration of gingival and submandibular lymph node tissues and significantly (p IL-6, IL-10, IL-12 (p70), eotaxin, G-CSF, GM-CSF, macrophage chemoattractant protein-1, macrophage inflammatory protein-? and -?, and TNF-? in isolated murine macrophages. In conclusion, P. gingivalis infection induced infiltration of functional/inflammatory M1 macrophages into gingival tissue and alveolar bone resorption. Macrophage depletion reduced P. gingivalis infection and alveolar bone resorption by modulating the host immune response. PMID:25070844

Lam, Roselind S; O'Brien-Simpson, Neil M; Lenzo, Jason C; Holden, James A; Brammar, Gail C; Walsh, Katrina A; McNaughtan, Judith E; Rowler, Dennis K; Van Rooijen, Nico; Reynolds, Eric C

2014-09-01

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Improving prosthetic prognosis by connective tissue ridge augmentation of alveolar ridge  

OpenAIRE

The contour of edentulous ridge should be carefully evaluated before a fixed partial denture is undertaken. The ideal ridge height and width allows placement of a natural looking pontic which facilitates maintenance of plaque-free environment. The localized alveolar ridge defect refers to the volumetric deficit of the limited extent of bone and soft tissue within the alveolar process. Such type of ridge defects can be corrected by surgical ridge augmentation that can be accomplished by the ad...

Mishra Niraj; Singh Balendra; Rao Jitendra; Rastogi Pavitra

2010-01-01

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Distracción osteogénica alveolar como método de aumento del reborde alveolar / Alveolar osteogenic distraction as method to increase the alveolar ridge  

Scientific Electronic Library Online (English)

Full Text Available La distracción osteogénica alveolar, como proceso biológico de neoformación de hueso alveolar, nos motivó a la realización de la presente revisión bibliográfica, con el objetivo enfatizar en el análisis de las variables: antecedentes históricos en Cuba, clasificación de los distractores, fases de la [...] distracción (latencia, distracción y consolidación), indicaciones, contraindicaciones, ventajas, desventajas y complicaciones. Se realizó una revisión bibliográfica mediante la consulta de bases de datos de los sistemas referativos, como MEDLINE y PubMed con la utilización de descriptores "alveolar distraction" y "osteogenic distraction". Se consultaron las fuentes bibliográficas publicadas fundamentalmente en los últimos 5 años, lo que reveló que esta técnica es una excelente alternativa para la formación de huesos y tejidos blandos en zonas de atrofia alveolar, que consta de tres etapas: latencia, distracción y consolidación; un método previsible y con bajas tasas de reabsorción ósea en comparación con otras técnicas de aumento del reborde alveolar. Tiene su principal indicación en la terapia de implantes al proveer volumen óseo. Debemos individualizar cada caso y usar el método más adecuado según las características clínicas y personales del paciente. Una adecuada selección de los casos y una mejor comprensión de la técnica son los puntales para lograr exitosos resultados mediante la distracción osteogénica alveolar. En Cuba se ha aplicado poco la distracción alveolar, por lo que ha sido necesario ampliar los estudios sobre esta temática. Abstract in english The alveolar osteogenic distraction, as a biological process of alveolar bone neoformation, motivates us to make the bibliographic review whose objective was to emphasize in analysis the following variables: historical backgrounds in Cuba, distraction classification, distraction phases (latency, dis [...] traction and consolidation), indications, contraindications, advantages, disadvantages and complications. A bibliographic review was made by database search of reference systems as MEDLINE and PubliMed using the descriptors "alveolar distraction" o "osteogenic distraction". The published bibliographic sources mainly over 5 years concluding that this technique is an excellent alternative for the bone and soft tissues formation in zones of alveolar atrophy including three stages: latency, distraction and consolidation; being a foreseeable method and with low rates of bone reabsorption compared to other techniques of increase of alveolar ridge. It has its main indication in implant therapy to provide bone volume. We must to individualize each case and to use the more appropriate method according the clinical and personal features of patient. A proper case selection and a better understand of technique are essential to achieve successful results by alveolar osteogenic distraction. In Cuba the alveolar distraction has been not much applied being necessary to expand the studies on this subject matter.

Denia, Morales Navarro.

2011-03-01

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Distracción osteogénica alveolar como método de aumento del reborde alveolar Alveolar osteogenic distraction as method to increase the alveolar ridge  

Directory of Open Access Journals (Sweden)

Full Text Available La distracción osteogénica alveolar, como proceso biológico de neoformación de hueso alveolar, nos motivó a la realización de la presente revisión bibliográfica, con el objetivo enfatizar en el análisis de las variables: antecedentes históricos en Cuba, clasificación de los distractores, fases de la distracción (latencia, distracción y consolidación, indicaciones, contraindicaciones, ventajas, desventajas y complicaciones. Se realizó una revisión bibliográfica mediante la consulta de bases de datos de los sistemas referativos, como MEDLINE y PubMed con la utilización de descriptores "alveolar distraction" y "osteogenic distraction". Se consultaron las fuentes bibliográficas publicadas fundamentalmente en los últimos 5 años, lo que reveló que esta técnica es una excelente alternativa para la formación de huesos y tejidos blandos en zonas de atrofia alveolar, que consta de tres etapas: latencia, distracción y consolidación; un método previsible y con bajas tasas de reabsorción ósea en comparación con otras técnicas de aumento del reborde alveolar. Tiene su principal indicación en la terapia de implantes al proveer volumen óseo. Debemos individualizar cada caso y usar el método más adecuado según las características clínicas y personales del paciente. Una adecuada selección de los casos y una mejor comprensión de la técnica son los puntales para lograr exitosos resultados mediante la distracción osteogénica alveolar. En Cuba se ha aplicado poco la distracción alveolar, por lo que ha sido necesario ampliar los estudios sobre esta temática.The alveolar osteogenic distraction, as a biological process of alveolar bone neoformation, motivates us to make the bibliographic review whose objective was to emphasize in analysis the following variables: historical backgrounds in Cuba, distraction classification, distraction phases (latency, distraction and consolidation, indications, contraindications, advantages, disadvantages and complications. A bibliographic review was made by database search of reference systems as MEDLINE and PubliMed using the descriptors "alveolar distraction" o "osteogenic distraction". The published bibliographic sources mainly over 5 years concluding that this technique is an excellent alternative for the bone and soft tissues formation in zones of alveolar atrophy including three stages: latency, distraction and consolidation; being a foreseeable method and with low rates of bone reabsorption compared to other techniques of increase of alveolar ridge. It has its main indication in implant therapy to provide bone volume. We must to individualize each case and to use the more appropriate method according the clinical and personal features of patient. A proper case selection and a better understand of technique are essential to achieve successful results by alveolar osteogenic distraction. In Cuba the alveolar distraction has been not much applied being necessary to expand the studies on this subject matter.

Denia Morales Navarro

2011-03-01

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Quantification and visualization of alveolar bone resorption from 3D dental CT images  

Energy Technology Data Exchange (ETDEWEB)

Purpose A computer aided diagnosis (CAD) system for quantifying and visualizing alveolar bone resorption caused by periodontitis was developed based on three-dimensional (3D) image processing of dental CT images. Methods The proposed system enables visualization and quantification of resorption of alveolar bone surrounding and between the roots of teeth. It has the following functions: (1) vertical measurement of the depth of resorption surrounding the tooth in 3D images, avoiding physical obstruction; (2) quantification of the amount of resorption in the furcation area; and (3) visualization of quantification results by pseudo-color maps, graphs, and motion pictures. The resorption measurement accuracy in the area surrounding teeth was evaluated by comparing with dentist's recognition on five real patient CT images, giving average absolute difference of 0.87 mm. An artificial image with mathematical truth was also used for measurement evaluation. Results The average absolute difference was 0.36 and 0.10 mm for surrounding and furcation areas, respectively. The system provides an intuitive presentation of the measurement results. Conclusion Computer aided diagnosis of 3D dental CT scans is feasible and the technique is a promising new tool for the quantitative evaluation of periodontal bone loss. (orig.)

Nagao, Jiro; Mori, Kensaku; Kitasaka, Takayuki; Suenaga, Yasuhito [Nagoya University, Graduate School of Information Science, Nagoya (Japan); Yamada, Shohzoh; Naitoh, Munetaka [Aichi-Gakuin University, School of Dentistry, Nagoya (Japan)

2007-06-15

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Quantification and visualization of alveolar bone resorption from 3D dental CT images  

International Nuclear Information System (INIS)

Purpose A computer aided diagnosis (CAD) system for quantifying and visualizing alveolar bone resorption caused by periodontitis was developed based on three-dimensional (3D) image processing of dental CT images. Methods The proposed system enables visualization and quantification of resorption of alveolar bone surrounding and between the roots of teeth. It has the following functions: (1) vertical measurement of the depth of resorption surrounding the tooth in 3D images, avoiding physical obstruction; (2) quantification of the amount of resorption in the furcation area; and (3) visualization of quantification results by pseudo-color maps, graphs, and motion pictures. The resorption measurement accuracy in the area surrounding teeth was evaluated by comparing with dentist's recognition on five real patient CT images, giving average absolute difference of 0.87 mm. An artificial image with mathematical truth was also used for measurement evaluation. Results The average absolute difference was 0.36 and 0.10 mm for surrounding and furcation areas, respectively. The system provides an intuitive presentation of the measurement results. Conclusion Computer aided diagnosis of 3D dental CT scans is feasible and the technique is a promising new tool for the quantitative evaluation of periodontal bone loss. (orig.)

10

Are Panoramic Radiographs Reliable to Diagnose Mild Alveolar Bone Resorption?  

Science.gov (United States)

It is extremely important to assess variations between the most used radiographs in dental practice, since minimum distortion on obtained images may change diagnosis, treatment plan, and prognosis for the patient. For this, the distance between the enamel-cementum junction and the alveolar bone crest was measured on conventional and digitized periapical, bitewing, and panoramic radiographs and compared among them. From a total of 1484 records, 39 sets of radiographs that fulfilled the inclusion criteria of the study sample were selected. The measurements were grouped according to the intensity of bone loss. Statistically significant difference was found in the averages of the measurements assessed in radiographs with absence of bone loss between conventional panoramic and periapical radiographs, between digitized panoramic and periapical radiographs and between digitized bitewing and panoramic radiographs. By analyzing the results of this work and considering the research protocol used, one can conclude that small losses in height of alveolar bone crest observed in panoramic radiographs should be cautiously evaluated, as they may be overestimated. PMID:21991470

Semenoff, Larissa; Semenoff, Tereza Aparecida Delle; Pedro, Fabio Luiz Miranda; Volpato, Evaristo Ricci; Machado, Maria Aparecida de Andrade Moreira; Borges, Álvaro Henrique; Semenoff-Segundo, Alex

2011-01-01

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Effects of smoking on edentulous alveolar ridge mucosa  

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Full Text Available Introduction Tobacco use is an important risk factor for advanced histopathological findings on edentulous alveolar ridge mucosa. The aim of this study was to examine the effects of smoking on histopathological findings on edentulous alveolar ridge mucosa. Material and methods The experimental group consisted of 48 patients (29 smokers and 19 nonsmokers. The mean age of smokers was 42.6 and of nonsmokers 48.7 years. The anamnesis included the following data: age, sex, diseases and toxic habits-cigarette smoking. Biopsy samples were taken from the edentulous alveolar ridge mucosa without gross signs of symptoms. Results The mean number of cigarettes smoked per day was 11.5±7. The results of ?² test proved that there were no statistically significant differences (p>0.05 in histopathological findings on the alveolar ridge mucosa. The mean duration of smoking was 12.7± 5 years. Hyperkeratosis was established in 76.92% of smokers who smoked longer than 15 years. The mean-age at which smokers began smoking was 27.3±8 years and there were no statistically significant differences in histopathological findings on the alveolar ridge mucosa correlated with the beginning of smoking. Conclusion On the basis of our research we conclude that smokers who have been smoking for 15 years are at risk for developing histopathological changes of the alveolar ridge mucosa, but there were no statistically significant differences in histopathological findings on the alveolar ridge mucosa correlated with the number of cigarettes per day and the beginning of smoking. .

Markovi? Dubravka

2005-01-01

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Combined soft and hard tissue augmentation for a localized alveolar ridge defect  

OpenAIRE

Ideal alveolar ridge width and height allows placement of a natural appearing pontic, which provides maintenance of a plaque-free environment. The contour of a partially edentulous ridge should be thoroughly evaluated before a fixed partial denture is undertaken. Localized alveolar ridge defect refers to a volumetric deficit of the limited extent of bone and soft-tissue within the alveolar process. These ridge defects can be corrected by hard tissue and/or soft-tissue augmentation. A 30-year-...

Rana, Ritu; Ramachandra, Srinivas Sulugodu; Lahori, Manesh; Singhal, Reetika; Jithendra, K. D.

2013-01-01

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¿Preservación del reborde alveolar? Toma de decisión ante la colocación de implantes dentales / Alveolar ridge preservation?: Decision making for dental implant placement  

Scientific Electronic Library Online (English)

Full Text Available La reabsorción ósea es una consecuencia fisiológica de la pérdida dental que puede convertirse en un riesgo funcional y estético significativo para la colocación de implantes dentales. Los cambios dimensionales del reborde alveolar pueden ser manejados con diferentes materiales de injerto y procedim [...] ientos quirúrgicos reportados en la literatura. El propósito de esta revisión es presentar las indicaciones y técnicas actuales utilizadas para ayudar a prevenir, en lo posible, la reabsorción del reborde residual asegurando el éxito de la rehabilitación sobre implantes. Abstract in english Bone resorption is a physiological consequence of tooth loss that could be a significant functional and an esthetic risk for dental implants. The dimensional changes of the alveolar ridge could be managed with different graft materials and surgical techniques that have been reported in the scientifi [...] c literature. The purpose of this review is to explore the indications and present actual techniques to help prevent residual ridge resorption, as much as possible, guaranteeing the success of Prosthodontic rehabilitation with implants.

Vanessa Louise, Ford-Martinelli; Gianna, Hanly; Juliana, Valenzuela; Lina Marcela, Herrera-Orozco; Sebastian, Muñoz-Zapata.

2012-07-01

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Inhibitory effects of French pine bark extract, pycnogenol(®) , on alveolar bone resorption and on the osteoclast differentiation.  

Science.gov (United States)

Pycnogenol(®) (PYC) is a standardized bark extract from French maritime pine (Pinus pinaster Aiton). We examined the inhibitory effects of PYC on alveolar bone resorption, which is a characteristic feature of periodontitis, induced by Porphyromonas gingivalis (P.?gingivalis) and osteoclast differentiation. In rat periodontitis model, rats were divided into four groups: group A served as the non-infected control, group B was infected orally with P.?gingivalis ATCC 33277, group C was administered PYC in the diet (0.025%: w/w), and group D was infected with P.?gingivalis and administered PYC. Administration of PYC along with P.?gingivalis infection significantly reduced alveolar bone resorption. Treatment of P.?gingivalis with 1?µg/ml PYC reduced the number of viable bacterial cells. Addition of PYC to epithelial cells inhibited adhesion and invasion by P.?gingivalis. The effect of PYC on osteoclast formation was confirmed by tartrate-resistant acid phosphatase staining. PYC treatment significantly inhibited osteoclast formation. Addition of PYC (1-100?µg/ml) to purified osteoclasts culture induced cell apoptosis. These results suggest that PYC may prevent alveolar bone resorption through its antibacterial activity against P.?gingivalis and by suppressing osteoclastogenesis. Therefore, PYC may be useful as a therapeutic and preventative agent for bone diseases such as periodontitis. Copyright © 2014 John Wiley & Sons, Ltd. PMID:25336411

Sugimoto, Hideki; Watanabe, Kiyoko; Toyama, Toshizo; Takahashi, Shun-Suke; Sugiyama, Shuta; Lee, Masaichi-Chang-Il; Hamada, Nobushiro

2015-02-01

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[Split crest to enlarge horizontal dimension of alveolar ridge. an overview of techniques and case demonstration].  

Science.gov (United States)

Restoration of the edentulous alveolar ridge with dental implants often requires the ridge width to be augmented in order to allow its placement. Technique of splitting the alveolar ridge aimed to enlarge its horizontal dimension is achieved by using different osseous surgical tools to allow simultaneous or staged placement of dental implants. Treatment of the thin alveolar ridge can be carried out predictably using ridge expansion technique. Good esthetic and functional outcomes can be achieved predictably as long as the surgical principles and protocols are followed carefully. A short literature overview of split crest techniques and a case presentation is included in this article. PMID:21667564

Moses, O; Blasbalg, Y; Herzberg, R

2011-01-01

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Aumento del reborde alveolar residual mediante técnica de rollo Increase of residual alveolar ridge using roll technique  

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Full Text Available La pérdida dentaria, asociada a factores sistémicos, patológicos y traumáticos, promueve el proceso de reabsorción ósea de los rebordes residuales y genera problemas funcionales, como la falta de estabilidad y retención de las prótesis dentarias removibles, y disturbios estéticos y psicológicos. Estos defectos varían en dependencia de la cantidad de pérdida ósea y de tejidos blandos que hayan alcanzado. En la actualidad son descritas diversas técnicas que permiten corregir estos defectos. Una de ellas es la técnica del rollo, la cual demuestra muy buenos resultados al aumentar el tamaño del reborde alveolar y disminuir los defectos estéticos que causa sobre todo en el sector anterior. El objetivo del presente artículo es describir el caso clínico de un paciente con pérdida ósea en el sector anterior, tipo III según Seibert, rehabilitado con prótesis parcial fija y sometido a un procedimiento quirúrgico con la técnica del rollo. Se alcanzaron los objetivos planteados y proporciona una mejoría estética así como una mejora en su calidad de vida. Se demostró que con esta técnica se obtienen resultados predecibles que devuelven la estética en zonas de alta exigencia por parte de los pacientes.Tooth loss associated with systemic factors, pathological and traumatic conditions, promotes the bone resorption of residual ridges, this, creates functional problems such as lack of stability and retention of removable dentures as well as aesthetic and psychological disturbances. These defects vary depending on the amount of bone loss and soft tissue they reach. At present there are described various techniques that can correct these defects. One of these is the roll technique which shows very good results by increasing the size of the alveolar ridge and decrease aesthetic defects in the anterior area of the maxilla. The aim of this article is to describe a case of a patient with Seibert bone loss type III, rehabilitated with fixed partial denture after undergoing a surgical procedure with the roll technique achieving the stated objectives and providing aesthetic improvement to the patient and an improvement in their quality of life. It is shown that the technique can be achieved with predictable results that return aesthetics in areas of high demand from patients.

Miguel Ángel Simancas Pallares

2011-03-01

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Analysis of correlation between initial alveolar bone density and apical root resorption after 12 months of orthodontic treatment without extraction  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: avaliar a correlação entre a densidade óssea alveolar inicial dos incisivos centrais superiores (DOA-IS) e a reabsorção radicular apical externa (RRAE) após 12 meses de movimentação ortodôntica em casos sem extração. MÉTODOS: quarenta e sete pacientes ortodônticos (maiores que 11 ano [...] s) foram submetidos ao exame periapical dos incisivos superiores no pré-tratamento (T1) e 12 meses após (T2). Mensurou-se a RRAE no intervalo de 12 meses, bem como a densidade óssea alveolar inicial da região apical desses dentes por meio da fotodensitometria. RESULTADOS: não houve correlação estatisticamente significativa entre a DOA-IS inicial e a RRAE em T2 (r = 0,149; p = 0,157). CONCLUSÃO: a densidade alveolar avaliada pela radiografia periapical não se apresentou como fator de interferência ou preditivo para reabsorção radicular após 12 meses de tratamento ortodôntico sem extração. Abstract in english OBJECTIVE: The aim of the present study was to investigate the correlation between initial alveolar bone density of upper central incisors (ABD-UI) and external apical root resorption (EARR) after 12 months of orthodontic movement in cases without extraction. METHODS: A total of 47 orthodontic [...] patients 11 years old or older were submitted to periapical radiography of upper incisors prior to treatment (T1) and after 12 months of treatment (T2). ABD-UI and EARR were measured by means of densitometry. RESULTS: No statistically significant correlation was found between initial ABD-UI and EARR at T2 (r = 0.149; p = 0.157). CONCLUSION: Based on the present findings, alveolar density assessed through periapical radiography is not predictive of root resorption after 12 months of orthodontic treatment in cases without extraction.

Paula Cabrini, Scheibel; Adilson Luiz, Ramos; Lilian Cristina Vessoni, Iwaki; Kelly Regina, Micheletti.

2014-10-01

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A preliminary study of local administration of dexamethasone after tooth extraction: Better preservation of residual alveolar ridge?  

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Full Text Available Background/Aim. It is important that the height of the edentulous alveolar ridge after tooth extraction remains at a reasonable acceptable level for as long as possible. The aim of this study was to report preliminary results of the clinical effect of local oral submucous administration of dexamethasone after tooth extractions in order to prepare alveolar supporting tissues for acceptance of removable dentures. Methods. In a total of 15 patients (11 partially and 4 completely edentulous the quantity of 0.25 mL to 0.5 mL of dexamethasone was injected bucally and orally in the region of the tooth socket after complicated extractions. Results. Healing of extraction wounds was uneventful in all the patients, without pain or local inflammation. Conclusion. Dexamethasone can be locally applied to oral tissues to prevent post-extraction inflammation and extensive resorption of the residual alveolar ridge. The obtained results are promising for patients undergoing classic prosthodontic rehabilitation soon after tooth extraction, demonstrating that there are no adverse effects after local oral corticosteroids administration. [Projekat Ministarstva nauke Republike Srbije, br. 175021

Pošti? Sr?an D.

2014-01-01

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To determine and compare the position of neutral zone in relation to crest of mandibular alveolar ridge with different duration of edentulousness: A clinico–radiographic study  

Science.gov (United States)

Purpose: The purpose of this study was to establish a relation between the crest of alveolar ridge and functionally obtained neutral zone and to determine the effect of duration of edentulousness on the location of neutral zone in relation to the crest of residual alveolar ridge. Materials and Methods: The study included three groups: Group I–15 subjects edentulous for 0 months to 2 years; Group 2–15 subjects edentulous for 2–5 years; and Group 3–15 subjects edentulous for more than 5 years. Neutral zone recording was performed for each subject and the buccolingual relationship of the crest of the mandibular alveolar ridge and position of the neutral zone was examined. The results were analyzed by the Kruskal–Wallis H test and the Chi-square test. Results: The results suggested that the location of the neutral zone varies from individual to individual depending on their musculature and that there is a significant relation to the duration of edentulousness. As edentulousness increases, there is more lingual positioning of the neutral zone at the molar region of both sides of the arch. At the premolar region, there is no change in position of the neutral zone; it remains constant as resorption of the alveolar ridge is directly under the buttress. In the anterior region, there is more labial positioning of the neutral zone as edentulousness increases. Conclusions: This technique proves itself to be an easy and inexpensive way to determine the relationship between the crest of alveolar ridge and neutral zone. Incorporating this technique into practice will be a great aid that can be exploited by the clinicians for functional and psychological comfort of the patients.

Jain, Ajay; Shetty, N. Sridhar; Ugrappa, Sridevi

2015-01-01

20

Horizontal ridge augmentation using a combination approach  

OpenAIRE

Resorption of alveolar bone - a common sequel of tooth loss jeopardizes the functional and esthetic outcome of treatment, especially in the maxillary anterior areas. Therefore, augmentation of deficient alveolar ridges is an important aspect of dental implant therapy. A case of severe maxillary ridge deficiency successfully treated with horizontal ridge augmentation to facilitate implant placement is described. Ridge augmentation was achieved using a combination of autogenous block graft, par...

Rachana, C.; Sridhar, N.; Rangan, Anand V.; Rajani, V.

2012-01-01

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Flapless alveolar ridge preservation utilizing the "socket-plug" technique: clinical technique and review of the literature.  

Science.gov (United States)

It has been documented that after every extraction of one or more teeth, the alveolar bone of the respective region undergoes resorption and atrophy. Therefore, ridge preservation techniques are often employed after tooth extraction to limit this phenomenon. The benefits of a flapless procedure include maintenance of the buccal keratinized gingiva, prevention of alterations to the gingival contours, and migration of the mucogingival junction that are often experienced after raising a flap. The purpose of this article is to review the literature concerning flapless ridge preservation techniques with the aid of collagen plugs for occlusion of the socket. The term "socket-plug" technique is introduced to describe these techniques. The basic steps of the "socket-plug" technique consist of atraumatic tooth extraction, placement of the appropriate biomaterials in the extraction site, preservation of soft tissue architecture employing a flapless technique, and placement and stabilization of the collagen plug. A case example is presented that illustrates the steps used in this technique. PMID:25506661

Kotsakis, Georgios; Chrepa, Vanessa; Marcou, Nicolas; Prasad, Hari; Hinrichs, James

2014-12-01

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Fresh-frozen human bone allograft in vertical ridge augmentation: clinical and tomographic evaluation of bone formation and resorption.  

Science.gov (United States)

The aim of the current study is to evaluate fresh-frozen human bone allografts (FHBAs) used in vertical ridge augmentation clinically and by computed tomography, and to analyze the resulting bone formation and graft resorption. Sixteen FHBAs were grafted in the maxillae and mandibles of 9 patients. The FHBAs, which were provided by the Musculoskeletal Tissue Bank of Marilia Hospital (Unioss), were frozen at -80°C. After 7 months, dental implants were placed and bone parameters were evaluated. Vertical bone formation was measured by computerized tomography before (T0) and at 7 months (T1) after the surgical procedure. Bone graft resorption was measured clinically from a landmark screw head using a periodontal probe. The results were analyzed by Student's t-test. Significant differences existed in the bone formation values at T0 and T1, with an average change of 4.03 ± 1.69 mm. Bone graft resorption values were 1.0 ± 0.82 mm (20%). Implants were placed with varying insertion torque values (35-45 Ncm), and achieved primary stability. This study demonstrates that FHBAs promote satisfactory vertical bone formation with a low resorption rates, good density, and primary implant stability. PMID:21811779

Macedo, Luis Guilherme Scavone; Mazzucchelli-Cosmo, Luiz Antonio; Macedo, Nelson Luiz; Monteiro, Adriana Socorro Ferreira; Sendyk, Wilson Roberto

2012-12-01

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Distracción osteogénica alveolar: una alternativa en la reconstrucción de rebordes alveolares atróficos: Descripción de 10 casos / Alveolar distraction osteogenesis: an alternative in the reconstruction of atrophic alveolar ridges: Report of 10 cases  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish La distracción osteogénica alveolar (DOA) es un método alternativo para la reconstrucción de rebordes alveolares atróficos que ofrece un resultado previsible y que disminuye los tiempo de espera entre la reconstrucción del reborde alveolar atrófico y la colocación de los implantes óseo-integrados, e [...] n comparación con los métodos tradicionalmente utilizados. Fueron atendidos 10 pacientes que presentaban deficiencia de reborde alveolar mandibular y/o maxilar por medio de distracción osteogénica, utilizando un dispositivo yuxtaoseo (Conexión Implant System® - SP-Brasil). Todos los pacientes fueron atendidos de forma ambulatoria, bajo anestesia local y sedación conciente, comenzando la activación del dispositivo a los 7 días posteriores a la instalación, con un patrón de activación de 1 mm diarios hasta alcanzar la altura ósea deseada. Posteriormente se aguardaron 10 semanas como parte del periodo de consolidación ósea y se realizo la colocación de los implantes oseointegrados y local y el retiro del dispositivo de distracción, pudiéndose comprobar clínica y radiográficamente la ganancia de la altura y volumen óseo necesario para la rehabilitación por medio de implantes. Abstract in english The alveolar distraction osteogenesis is an alternative method for the reconstruction of atrophic alveolar ridges with success, that decrease the time of wait between the reconstruction of the alveolar ridge and the placement of the osseointegrated implants in comparison with the traditionally used [...] methods. 10 patients that presented deficiency of the alveolar ridge in the maxilla and/or mandible were assisted by means of distraction osteogenesis, using a juxtaosseous device (Conexion Implant System® - SP-Brazil). All the patients were assisted of form ambulatory, under local anesthesia and conscientious sedation, beginning the activation from the device 7 days later to the installation, with a pattern of activation 1 mm diary until reaching the wanted bony height. Later on 10 weeks like part of the period of bony consolidation were awaited and one carries out the placement of the osseointegraded implants and the retirement of the distraction device, being able to check clinic and radiographic the gain of the height and necessary bony volume for the rehabilitation by means of implants.

P.E., Maurette O’Brien; M.E., Allais de Maurette; R., Mazzonetto.

2004-02-01

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Distracción osteogénica alveolar: una alternativa en la reconstrucción de rebordes alveolares atróficos: Descripción de 10 casos Alveolar distraction osteogenesis: an alternative in the reconstruction of atrophic alveolar ridges: Report of 10 cases  

Directory of Open Access Journals (Sweden)

Full Text Available La distracción osteogénica alveolar (DOA es un método alternativo para la reconstrucción de rebordes alveolares atróficos que ofrece un resultado previsible y que disminuye los tiempo de espera entre la reconstrucción del reborde alveolar atrófico y la colocación de los implantes óseo-integrados, en comparación con los métodos tradicionalmente utilizados. Fueron atendidos 10 pacientes que presentaban deficiencia de reborde alveolar mandibular y/o maxilar por medio de distracción osteogénica, utilizando un dispositivo yuxtaoseo (Conexión Implant System® - SP-Brasil. Todos los pacientes fueron atendidos de forma ambulatoria, bajo anestesia local y sedación conciente, comenzando la activación del dispositivo a los 7 días posteriores a la instalación, con un patrón de activación de 1 mm diarios hasta alcanzar la altura ósea deseada. Posteriormente se aguardaron 10 semanas como parte del periodo de consolidación ósea y se realizo la colocación de los implantes oseointegrados y local y el retiro del dispositivo de distracción, pudiéndose comprobar clínica y radiográficamente la ganancia de la altura y volumen óseo necesario para la rehabilitación por medio de implantes.The alveolar distraction osteogenesis is an alternative method for the reconstruction of atrophic alveolar ridges with success, that decrease the time of wait between the reconstruction of the alveolar ridge and the placement of the osseointegrated implants in comparison with the traditionally used methods. 10 patients that presented deficiency of the alveolar ridge in the maxilla and/or mandible were assisted by means of distraction osteogenesis, using a juxtaosseous device (Conexion Implant System® - SP-Brazil. All the patients were assisted of form ambulatory, under local anesthesia and conscientious sedation, beginning the activation from the device 7 days later to the installation, with a pattern of activation 1 mm diary until reaching the wanted bony height. Later on 10 weeks like part of the period of bony consolidation were awaited and one carries out the placement of the osseointegraded implants and the retirement of the distraction device, being able to check clinic and radiographic the gain of the height and necessary bony volume for the rehabilitation by means of implants.

P.E. Maurette O’Brien

2004-02-01

25

Post traumatic immediate GBR: alveolar ridge preservation after a comminuted fracture of the anterior maxilla.  

Science.gov (United States)

Without a proper intervention, a crushed alveolar process fracture can cause significant dimensional changes on affected hard and soft tissue that lead to difficult circumstances for post traumatic bone augmentation and dental implant placement. We present herein the cases of immediate guided bone regeneration (GBR) for the maxillary anterior alveolar process with comminuted fracture. Shortly after the hospital visit, guided bone regeneration was conducted for three patients using only xenograft material and bone fragments from traumatic site, without an additional donor site. Resorbable collagen membrane was used on the bone graft site, and titanium mesh was also used if significant bone loss were expected. Radiographic evaluation 6 months after GBR confirmed that all three cases had sufficiently preserved alveolar bone which is clinically required for implant placement. Dental implant installation was carried out for two patients and no specific findings were noted in follow-up after the placement. In this method, additional operation sites for bone collection are not necessary and the number of surgical steps before implant placement can be reduced. Furthermore, this immediate intervention can effectively minimize the alveolar ridge shrinkage of anterior maxilla after injury. PMID:25351617

Kim, Yongsoo; Leem, Dae Ho

2015-04-01

26

Chemical, physical, and histologic studies on four commercial apatites used for alveolar ridge augmentation  

DEFF Research Database (Denmark)

The purpose of this study was to evaluate four commercial apatite products. Subperiosteal alveolar ridge augmentation was performed on the maxilla of rats by implantation of granules of two dense products and of two porous products, and the tissue response was compared with the material characteristics obtained by chemical analysis and infrared spectrometry. None of the apatites caused osteoinduction or osteoconduction; fibrous encapsulation with multinuclear giant cells was observed around all four types. One of the apatites was fluorapatite and not hydroxylapatite, as claimed by the manufacturer. The tissue response to this implant material was dominated by multinuclear giant cells.

Pinholt, E M; Ruyter, I E

1992-01-01

27

The effect of therapeutic radiation on canine alveolar ridges augmented with hydroxylapatite  

DEFF Research Database (Denmark)

The purpose of this investigation was to evaluate the effect of radiation on hydroxylapatite (HA) implanted subperiosteally for alveolar ridge augmentation in dogs. All bicuspids and molars were extracted from 16 dogs. After 6 weeks, nonporous HA granules were implanted subperiosteally on the alveolar ridge. Following 4 months of healing, 12 dogs (experimental group) underwent therapeutic radiation therapy (Co60, 4,000 rad [40 Gy]) to the head and neck region. Four dogs were not irradiated and served as controls. Four animals (three experimental and one control) were killed at 5,6,7, and 8 months after HA augmentation. Light microscopic evaluation showed that approximately 25% of HA granules were encased by bone while the others were surrounded by fibrous connective tissue. Dissolution of the HA was observed. Microparticles of HA were phagocytized as part of a granulomatous inflammatory reaction. This reaction decreased significantly as time elapsed after implantation. Osteoclastic activity was seen at the junction of HA and periosteum and as part of bone remodeling. Dissolution of the HA granules and the granulomatous inflammatory reaction were not significantly increased by therapeutic radiation. The radiation did not cause development of dehiscence or osteonecrosis.

Pinholt, E M; Kwon, P H

1992-01-01

28

Ridge Augmentation and Root Coverage Using Acellular Dermal Matrix: A Case Report  

OpenAIRE

Excessive alveolar bone resorption is commonly found when teeth are extracted. This is a problem in anterior part of mouth because it will result in an unaesthetic pontic on a narrow hollowed out alveolar ridge. Yet, another problem is gingival recession and root exposure in adjacent teeth which represent a therapeutic problem to the clinician.

Jayavel, Kavitha; Swaminathan, Mythili; Kumar, Senthil

2010-01-01

29

Clinical Results of Localized Alveolar Ridge Augmentation with Bone Grafts Harvested from Symphysis in Comparison with Ramus  

OpenAIRE

Background and aims. Autogenous onlay bone grafting is a common procedure for alveolar ridge augmentation. It has been suggested that the amount of healed bone after this technique would be significantly less than the initial quantity. The aim of this study was to determine the relationship between the various parameters influencing the outcome of ridge augmentation procedures.

Materials and methods. Thirty-...

Reza Pourabbas; Saeed Nezafati

2007-01-01

30

Comparison of alveolar ridge preservation method using three dimensional micro-computed tomographic analysis and two dimensional histometric evaluation  

Energy Technology Data Exchange (ETDEWEB)

This study evaluated the efficacy of alveolar ridge preservation methods with and without primary wound closure and the relationship between histometric and micro-computed tomographic (CT) data. Porcine hydroxyapatite with polytetrafluoroethylene membrane was implanted into a canine extraction socket. The density of the total mineralized tissue, remaining hydroxyapatite, and new bone was analyzed by histometry and micro-CT. The statistical association between these methods was evaluated. Histometry and micro-CT showed that the group which underwent alveolar preservation without primary wound closure had significantly higher new bone density than the group with primary wound closure (P<0.05). However, there was no significant association between the data from histometry and micro-CT analysis. These results suggest that alveolar ridge preservation without primary wound closure enhanced new bone formation more effectively than that with primary wound closure. Further investigation is needed with respect to the comparison of histometry and micro-CT analysis.

Park, Young Seok; Kim, Sung Tae; Oh, Seung Hee; Park, Hee Jung; Lee, Sophia; Kim, Taeil; Lee, Young Kyu; Heo, Min Suk [School of Dentistry, Seoul National University, Seoul (Korea, Republic of)

2014-06-15

31

Comparison of alveolar ridge preservation method using three dimensional micro-computed tomographic analysis and two dimensional histometric evaluation  

International Nuclear Information System (INIS)

This study evaluated the efficacy of alveolar ridge preservation methods with and without primary wound closure and the relationship between histometric and micro-computed tomographic (CT) data. Porcine hydroxyapatite with polytetrafluoroethylene membrane was implanted into a canine extraction socket. The density of the total mineralized tissue, remaining hydroxyapatite, and new bone was analyzed by histometry and micro-CT. The statistical association between these methods was evaluated. Histometry and micro-CT showed that the group which underwent alveolar preservation without primary wound closure had significantly higher new bone density than the group with primary wound closure (P<0.05). However, there was no significant association between the data from histometry and micro-CT analysis. These results suggest that alveolar ridge preservation without primary wound closure enhanced new bone formation more effectively than that with primary wound closure. Further investigation is needed with respect to the comparison of histometry and micro-CT analysis.

32

Reliability of pain tolerance threshold testing by applying an electrical current stimulus to the alveolar ridge.  

Science.gov (United States)

The purpose of this study was to assess the reliability of testing pain tolerance threshold (PTT) by applying an electrical current stimulus to the alveolar ridge. Twenty volunteers studying or working at the Nihon University School of Dentistry at Matsudo participated in this study. Participants were seated comfortably on a dental chair in a quiet room during testing. A single operator obtained mucosal PTT measurements around the right greater palatine foramen using a Neurometer CPT/C(®) device (Neurotron Inc., Baltimore, MD, USA) to deliver electrical stimulation at frequencies of 5, 250 and 2000 Hz. The participant released a button to automatically discontinue the stimulus when it could no longer be tolerated. Two types of factors were confirmed: the consistency of repeated measurements and a potential carry-over effect on PTTs. The consistency and carry-over effects of pain with regard to PTT measurements were analysed via Cronbach's coefficient ?. The Cronbach's coefficient ? of PTTs calculated more than 6 days of PTT testing at 5, 250 and 2000 Hz was 0.97, 0.95 and 0.97, respectively, suggesting that the consistency of the measurements was excellent. The Cronbach's coefficient ? calculated when the three frequencies of 5, 250 and 2000 Hz were applied in different orders was 0.91, 0.87 and 0.90, respectively, suggesting no carry-over effect. In conclusion, the measurement of PTTs at the alveolar ridge as assessed by applying an electrical current stimulus with an electro-diagnostic device exhibited excellent reliability, and thus, it constitutes a widely available option for PTT measurement in the clinical setting. PMID:24814257

Nakashima, Y; Kimoto, S; Kawai, Y

2014-08-01

33

Regeneración ósea guiada para el aumento vertical del reborde alveolar / Guided osseous regeneration for the vertical augmentation of the alveolar ridge  

Scientific Electronic Library Online (English)

Full Text Available SciELO Chile | Language: Spanish Abstract in spanish Se considera como aumento óseo vertical, cualquier técnica que apunte a crear una mayor altura del reborde alveolar. A inicios de la década de los 90’s se empezó a utilizar la regeneración ósea guiada (ROG) en mandíbulas atróficas, con el fin de permitir la instalación de implantes óseointegrados. C [...] on el fin de evaluar y exponer parte de la evidencia disponible en la actualidad, con respecto a la ROG para aumento óseo vertical, se realizó la siguiente revisión bibliográfica. Abstract in english Any technique aimed to improve the alveolar ridge height is considered as a vertical bone augmentation procedure. In the early 90’s guided bone regeneration (GBR) procedures began to be used in atrophic mandibles to allow the installation of osseointegrated dental implants. The following bibliograph [...] ic review was made with the purpose of evaluating and exposing part of the available evidence at present in this field.

CE, Nappe; CE, Baltodano.

2013-04-01

34

Photoelastic Stress Analysis Surrounding Implant-Supported Prosthesis and Alveolar Ridge on Mandibular Overdentures  

Directory of Open Access Journals (Sweden)

Full Text Available The purpose of this research was to evaluate the maximum stress around osseointegrated implants and alveolar ridge, in a mandible with left partial resection through a photoelastic mandibular model. The first group consisted of two implants: traditional model (T, implants placed in the position of both canines; fulcrum model (F, implants placed in the position of left canine CL and right lateral incisor LiR. Both models linked through a bar and clips. The second group was consisted of three implants, with implants placed in the position of both canines (CR and CL and the right lateral incisor (LiR, which composed four groups: (1 model with 3 “O” rings, (2 model 2 ERAs, bar with clips, (3 model 2 ERAs bar without clips; (4 model “O” ring bar and ERA. An axial and an oblique load of 6.8?kgf was applied on a overdenture at the 1st Pm, 2nd Pm, and 1st M. Results showed that the area around the left canine (CL was practically free of stress; the left lateral incisor (LiL developed only small tensions, and low stress in all the other cases; the right canine tooth suffered the largest concentrations of stress, mainly with the ERA retention mechanism.

Rafael Yagüe Ballester

2010-01-01

35

Efficacy of Enamel Matrix Derivative on Alveolar Ridge Augmentation by Distraction Osteogenesis  

Directory of Open Access Journals (Sweden)

Full Text Available Distraction osteogenesis (DO is a surgical-orthopedic technique for lengthening a bone by separating or distracting a fractured callus. The aim of this study was to observe the effects of an enamel matrix derivative (EMD on bone repair and regeneration after DO on a canine mandible. Ten adult beagle dogs were used in this study. Their right and left mandibles were compared as the test and control groups, respectively. The distraction was undertaken at a rate of 1 mm per day for 10 consecutive days to yield 10 mm lengthening of the mandibular corpus. The EMD was treated into the test group at the site of the lengthened bone. At 0, 1, 3, 6 and 9 weeks after EMD treatment, the bone mineral density (BMD at the site of the lengthened bone was measured using quantitative computed tomography. BMD in the tested group was higher during consolidation period than in the control. The difference in the BMD of 1 and 3 weeks after EMD treatment was significant (p < 0.05. In histological findings, new bone formation in the test group was denser than the control group. These results suggest that the application of an EMD during DO is suitable method for alveolar ridge augmentation in dogs.

J.M. Kim, J.H. Kim, T.S. Han, G. Kim, S.S. Kang1 and S.H. Choi*

2011-04-01

36

Altered position of the medial lingual nutritional foramina at different stages of alveolar ridge atrophy.  

Science.gov (United States)

To determine the altered location of the medial lingual nutritional foramina in different stages of bone resorption, 55 cadaveric mandibles were selected for this study from a total of 1532. Prevalence, location of the foramen (lingual, cranial, labial), application of Atwood classification (grades 1-6), and macroanatomic dissections were tools of this examination. An increasing grade of atrophy leads to a shift in position of the medial lingual nutritional foramen. PMID:22103707

Lautner, Nora Valerie; Bernauer, Erwin; Krenkel, Christian; Gaggl, Alexander

2014-02-01

37

Alveolar ridge preservation of an extraction socket using autogenous tooth bone graft material for implant site development: prospective case series  

Science.gov (United States)

This case series evaluated the clinical efficacy of autogenous tooth bone graft material (AutoBT) in alveolar ridge preservation of an extraction socket. Thirteen patients who received extraction socket graft using AutoBT followed by delayed implant placements from Nov. 2008 to Aug. 2010 were evaluated. A total of fifteen implants were placed. The primary and secondary stability of the placed implants were an average of 58 ISQ and 77.9 ISQ, respectively. The average amount of crestal bone loss around the implant was 0.05 mm during an average of 22.5 months (from 12 to 34 months) of functional loading. Newly formed tissues were evident from the 3-month specimen. Within the limitations of this case, autogenous tooth bone graft material can be a favorable bone substitute for extraction socket graft due to its good bone remodeling and osteoconductivity. PMID:25551013

Yun, Pil-Young; Um, In-Woong; Lee, Hyo-Jung; Yi, Yang-Jin; Bae, Ji-Hyun; Lee, Junho

2014-01-01

38

Volume changes of autogenous bone grafts after alveolar ridge augmentation of atrophic maxillae and mandibles.  

Science.gov (United States)

The aim of the present retrospective chart review was to determine the relationship between nonvascularized osseous graft remodeling and the three-dimensional (3D) features of grafts and recipient sites, the anatomical recipient regions and different graft sources. 32 iliac crest or chin grafts were onlay-positioned in the mandible or maxilla of 14 patients. CT scans, taken before implant positioning and after 1 year, revealed a mean volume resorption of 35-51%. For iliac crest grafts, the average resorption was 42% when the onlay was positioned in the anterior maxilla and 59% when it was positioned in the posterior mandible. Spearman correlation and 3D interpolation analysis revealed, for both iliac crest groups, a moderate or advanced remodeling pattern depending on 3D features, namely graft thickness and shape, basal bone volume of recipient site, and the basal bone/graft volume ratio of the recipient site. No statistically significant differences were found between the recipient and donor site groups. Retrospective analysis of the data indicates that iliac crest grafts, onlay-positioned on adequate basal bone volume, may register a reduced volume remodeling when shaped thick in the anterior maxilla or rounded and convex, on the external surface, in the posterior mandible. PMID:19632815

Sbordone, L; Toti, P; Menchini-Fabris, G B; Sbordone, C; Piombino, P; Guidetti, F

2009-10-01

39

Lateral alveolar ridge augmentation using tenting screws, acellular dermal matrix, and freeze-dried bone allograft alone or with particulate autogenous bone.  

Science.gov (United States)

This randomized prospective study evaluated the clinical benefits of using a corticocancellous mixture of freeze-dried bone allograft alone or in combination (1:1) with particulated autogenous bone for horizontal ridge augmentation and subsequent implant placement. Twenty-four patients with atrophic ridges received lateral ridge augmentations with particulate grafts placed around tenting screws and covered with a fixed acellular dermal matrix membrane. Thirty-three standard-diameter implants were successfully placed in 21 patients after a 24-week graft healing period. Three patients experienced early postoperative infections following the grafting procedure (12.5% of sites). At reentry, the allograft alone group showed similar average horizontal ridge width gains (3.33 ± 0.83 mm) to the combination group (3.09 ± 0.63 mm; P = .44). The mean graft resorption between baseline and reentry averaged 13.89%. PMID:25734709

Caldwell, Gregory R; Mills, Michael P; Finlayson, Richard; Mealey, Brian L

2015-01-01

40

Surgical Combined Approach for Alveolar Ridge Augmentation with Titanium Mesh and rhPDGF-BB: A 3-Year Clinical Case Series.  

Science.gov (United States)

The purpose of this case series was to report the clinical outcomes and histologic findings of vertical ridge augmentation using a combination of titanium mesh and recombinant human platelet-derived growth factor BB (rhPDGF-BB). Two patients were included, and anorganic bovine bone particles were used. The bone graft was mixed with rhPDGF-BB and loaded onto the bony defect up to the level of the adjacent alveolar crest. A preadapted titanium mesh was placed over the grafted region; no areas of the grafted region were exposed. Postoperative healing was without complications. During reentry surgery for removal of the titanium mesh, all implants could be placed according to the prosthetic design. This report demonstrates the remarkable efficacy of guided bone regeneration using a combination of titanium mesh and rhPDGF for vertical ridge augmentation, thus expanding the indications for implant therapy and allowing recovery of the three-dimensional esthetic architecture in a severely resorbed alveolar ridge. PMID:25738343

De Angelis, Nicola; De Lorenzi, Marco; Benedicenti, Stefano

2015-01-01

41

Assessment of marginal bone loss using full thickness versus partial thickness flaps for alveolar ridge splitting and immediate implant placement in the anterior maxilla.  

Science.gov (United States)

The aim of this study was to evaluate the effectiveness of maintaining the periosteal attachment of the facial and palatal cortical plates on crestal bone loss that occurs at the margin of dental implants placed immediately in split anterior maxillary alveolar ridges. This was a prospective randomized comparative clinical trial. The study population included 22 patients with edentulous anterior maxillary alveolar ridges who presented for treatment during the period March 2012 to September 2013. The selected patients were divided randomly into two equal groups. All patients underwent a maxillary ridge splitting technique; a total of 43 implants were placed immediately. A full thickness mucoperiosteal flap was performed in the control group patients, while a split thickness mucosal flap was done in the study group patients. Assessments included measurements of the linear changes in the marginal bone surrounding the implants immediately postoperative and after 6 months. Measurements were taken from cross-sectional and longitudinal cone beam computed tomography images using special software. The partial thickness flap used in the study group decreased the percentage of bone loss by 9.5% for the labial bone plate, 7.9% for the palatal bone plate, and 3.5% for the mesiodistal bone plate. PMID:24973295

Mounir, M; Beheiri, G; El-Beialy, W

2014-11-01

42

A novel combined surgical approach to vertical alveolar ridge augmentation with titanium mesh, resorbable membrane, and rhPDGF-BB: a retrospective consecutive case series.  

Science.gov (United States)

The purpose of this case series was to report the clinical outcomes and histologic findings of vertical ridge augmentation using a combination of titanium mesh, resorbable collagen membrane, and recombinant human platelet-derived growth factor BB (rhPDGF-BB). Nineteen patients were included, and autogenous bone and anorganic bovine bone particles were used. The bone graft was mixed with rhPDGF-BB and loaded onto the bony defect up to the level of the adjacent alveolar crest. A pre-adapted titanium mesh was placed over the grafted region and covered with a resorbable collagen membrane, leaving no areas of the grafted region exposed. Seventeen patients exhibited good soft tissue healing. Postoperative flap dehiscence occurred relatively early in the healing period in one patient, whereas the covering collagen membrane was exposed during the later phase of the healing period in another. During reentry surgery for removal of the titanium mesh, three patients with favorable soft and hard tissue healing underwent bone biopsies for histologic evaluation of the augmented tissue just below the titanium mesh. The mean vertical height of augmented bone was 8.6 ± 4.0 mm. This report demonstrates the remarkable efficacy of guided bone regeneration using a combination of titanium mesh, resorbable collagen membrane, and rhPDGF for vertical ridge augmentation, thus expanding the indications for implant therapy and allowing recovery of the three-dimensional esthetic architecture in a severely absorbed alveolar ridge. PMID:23820701

Funato, Akiyoshi; Ishikawa, Tomohiro; Kitajima, Hajime; Yamada, Masahiro; Moroi, Hidetada

2013-01-01

43

Frequency of the external resorptions of root apex  

Directory of Open Access Journals (Sweden)

Full Text Available Root resorptions present a significant problem in endodontic therapy of the affected teeth and in dentistry in general. The objective of this study was to analyze, based on epidemiological and statistical research, the frequency of clinical incidence of pathological root resorptions in everyday practice related to localization, type of tooth, age and sex of patients. Radiographie documentation of patients treated from 1997 till 2002 at the Department of Conservative Dentistry and Endodontics, Faculty of Stomatology in Belgrade, was used as baseline for this study. Retroalveolar radiographs of teeth with visible signs of resorptions were singled out from 15654 patients' clinical records used for this study. The external resorptions were shown as radiolucent areas localized on various outer root surfaces, followed by significant or less significant resorption of lamina dura and alveolar bone. Out of all teeth analyzed in this study, 594 (3.79% showed some kind of resorption. The external resorptions were found to be more present in the upper jaw (55.10% and molars (50.30% than in the lower jaw (44.90% and single root teeth (49.70%, but in both cases without significant statistical differences. The most frequent localization of resorptions was root apex (82.44%. In regard to age, the most frequent resorptions were recorded in patients aged between 21 and 30 years (28.40%, and the lowest incidence was found in the youngest population (5.51%. The results also showed that resorptions were more frequent among the female population (59.04% than among the male population (40.96%. Based on these results, we may conclude that the external root resorptions are not a frequent clinical phenomenon. Proper and early diagnostics of such tissue pathology is one of the basic prerequisites for successful endodontic therapy of the affected root.

Opa?i?-Gali? Vanja

2004-01-01

44

Invasive Cervical Resorption: A Review  

OpenAIRE

Invasive cervical resorption is a relatively uncommon form of external root resorption exhibiting no external signs. The resorptive condition is often detected by routine radiographic examination. The clinical features vary from a small defect at the gingival margin to a pink coronal discoloration of the tooth crown resulting in ultimate cavitation of the overlying enamel which is painless unless pulpal or periodontal infection supervenes. Radiographic features of lesions vary from well-delin...

Kandalgaonkar, Shilpa D.; Gharat, Leena A.; Tupsakhare, Suyog D.; Gabhane, Mahesh H.

2013-01-01

45

Multiple idiopathic apical root resorption.  

Science.gov (United States)

Idiopathic external root resorption is a rarely reported condition which has been observed in single or multiple teeth. This is a rare case of multiple idiopathic apical root resorption (MIARR) in a 16-year-old boy. External root resorption of the permanent teeth is a multifactorial process. Well-recognised causes of apical root resorption in permanent teeth include orthodontic therapy, trauma, periapical or periodontal inflammation, tumours, cysts, occlusal stresses, impacted teeth, systemic conditions, endocrine imbalances and dietary habits. When none of these causes are present, it is termed idiopathic root resorption which may be either cervical or apical. MIARR is a rare condition which is usually detected as an incidental radiographic finding. However, it may cause pain and mobility in severe cases. PMID:23616336

Kanungo, Manish; Khandelwal, Vishal; Nayak, Ullal Anand; Nayak, Prathibha Anand

2013-01-01

46

Ridge Preservation with Modified “Socket-Shield” Technique: A Methodological Case Series  

Directory of Open Access Journals (Sweden)

Full Text Available After tooth extraction, the alveolar bone undergoes a remodeling process, which leads to horizontal and vertical bone loss. These resorption processes complicate dental rehabilitation, particularly in connection with implants. Various methods of guided bone regeneration (GBR have been described to retain the original dimension of the bone after extraction. Most procedures use filler materials and membranes to support the buccal plate and soft tissue, to stabilize the coagulum and to prevent epithelial ingrowth. It has also been suggested that resorption of the buccal bundle bone can be avoided by leaving a buccal root segment (socket shield technique in place, because the biological integrity of the buccal periodontium (bundle bone remains untouched. This method has also been described in connection with immediate implant placement. The present case report describes three consecutive cases in which a modified method was applied as part of a delayed implantation. The latter was carried out after six months, and during re-entry the new bone formation in the alveolar bone and the residual ridge was clinically evaluated as proof of principle. It was demonstrated that the bone was clinically preserved with this method. Possibilities and limitations are discussed and directions for future research are disclosed.

Markus Glocker

2014-01-01

47

Invasive Cervical Resorption: A Review  

Science.gov (United States)

Invasive cervical resorption is a relatively uncommon form of external root resorption exhibiting no external signs. The resorptive condition is often detected by routine radiographic examination. The clinical features vary from a small defect at the gingival margin to a pink coronal discoloration of the tooth crown resulting in ultimate cavitation of the overlying enamel which is painless unless pulpal or periodontal infection supervenes. Radiographic features of lesions vary from well-delineated to irregularly bordered mottled radiolucencies, and these can be confused with dental caries. A characteristic radiopaque line generally separates the image of the lesion from that of the root canal, because the pulp remains protected by a thin layer of predentin until late in the process. Histopathologically, the lesions contain fibrovascular tissue with resorbing clastic cells adjacent to the dentin surface. More advanced lesions display fibro-osseous characteristics with deposition of ectopic bonelike calcifications both within the resorbing tissue and directly on the dentin surface. How to cite this article: Kandalgaonkar SD, Gharat LA, Tupsakhare SD, Gabhane MH. Invasive Cervical Resorption: A Review. J Int Oral Health 2013;5(6):124-30 . PMID:24453457

Kandalgaonkar, Shilpa D; Gharat, Leena A; Tupsakhare, Suyog D; Gabhane, Mahesh H

2013-01-01

48

Influence of anatomical barriers on maxillary incisor root resorption after orthodontic treatment with premolar extractions  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english INTRODUCTION: Apical root resorption is a frequent and occasionally critical problem in orthodontic patients undergoing induced tooth movement. One of the factors that might influence prognosis, especially in maxillary incisors, which most frequently present resorptions, are the so-called the anatom [...] ical barriers; that is, proximity of the buccal and palatal cortical bones to the maxillary incisor roots. OBJECTIVE: The purpose of this research was to investigate whether patients with excessive vertical growth really present a small distance between the alveolar cortical bones and the maxillary incisor roots, and whether there is a correlation between this distance and the root resorption index in comparison with patients presenting horizontal growth. METHODS: The sample comprised orthodontic records of 18 patients with extraction planning of first maxillary premolars and treatment by the standard and/or preadjusted edgewise brackets. Their initial and final periapical radiographs were evaluated to determine the amount of root resorption that occurred. RESULTS: On the palatal side, patients with excessive vertical growth (Group 2 - SN-GoGn > 43º) showed a narrower alveolar bone than the horizontal growth patients (Group 1 - SN-GoGn

Antonio Geraldo de, Oliveira; Fabiana Guilhermina Ferreira, Castro.

2012-04-01

49

Strontium ranelate improved tooth anchorage and reduced root resorption in orthodontic treatment of rats.  

Science.gov (United States)

The anchorage mechanisms currently used in orthodontic treatment have various disadvantages. The objective of this study was to determine the applicability of the osteoporosis medication strontium ranelate in pharmacologically induced orthodontic tooth anchorage. In 48 male Wistar rats, a constant orthodontic force of 0.25 N was reciprocally applied to the upper first molar and the incisors by means of a Sentalloy(®) closed coil spring for two to four weeks. 50% of the animals received strontium ranelate at a daily oral dosage of 900 mg per kilogramme of body weight. Bioavailability was determined by blood analyses. The extent of tooth movement was measured both optometrically and cephalometrically (CBCT). Relative alveolar gene expression of osteoclastic markers and OPG-RANKL was assessed by qRT-PCR and root resorption area and osteoclastic activity were determined in TRAP-stained histologic sections of the alveolar process. Compared to controls, the animals treated with strontium ranelate showed up to 40% less tooth movement after four weeks of orthodontic treatment. Gene expression and histologic analyses showed significantly less osteoclastic activity and a significantly smaller root resorption area. Blood analyses confirmed sufficient bioavailability of strontium ranelate. Because of its pharmacologic effects on bone metabolism, strontium ranelate significantly reduced tooth movement and root resorption in orthodontic treatment of rats. Strontium ranelate may be a viable agent for inducing tooth anchorage and reducing undesired root resorption in orthodontic treatment. Patients under medication of strontium ranelate have to expect prolonged orthodontic treatment times. PMID:25281203

Kirschneck, Christian; Wolf, Michael; Reicheneder, Claudia; Wahlmann, Ulrich; Proff, Peter; Roemer, Piero

2014-12-01

50

Pulmonary alveolar proteinosis  

OpenAIRE

Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterised by alveolar accumulation of surfactant. It may result from mutations in surfactant proteins or granulocyte macrophage-colony stimulating factor (GM-CSF) receptor genes, it may be secondary to toxic inhalation or haematological disorders, or it may be auto-immune, with anti-GM-CSF antibodies blocking activation of alveolar macrophages. Auto-immune alveolar proteinosis is the most frequent form of PAP, representing 9...

Crestani, B.; Epaud, R.; Aubier, M.; M-c, Dombret; Taille, C.; M-p, Debray; Danel, C.; Borie, R.

2011-01-01

51

Analysis of the prevalence of different topographical characteristics of the residual ridge in mandibular free-end arches / Análise da prevalência de diferentes características topográficas do rebordo residual em arcos mandibulares com extremidades livres  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Esta pesquisa constatou a prevalência dos tipos de rebordos residuais no sentido ântero-posterior em extremidades livres inferiores, além de correlacionar alguns fatores que possam influenciar as suas reabsorções. Para isso, utilizamos radiografias periapicais e dados individuais colhidos na amostra [...] de 64 hemiarcos; foram obtidas 2 radiografias de cada área de extremidade livre e, a partir de traçados, determinamos os ângulos formados pela reabsorção na altura do 1º molar inferior. Podemos constatar que: 1º) a grande maioria de inclinação encontrada foi de rebordos descendentes para distal; 2º) a média de angulação foi maior para usuários de prótese parcial removível inferior; 3º) os resultados sugeriram existir influência do tipo de arco antagônico superior na inclinação dos rebordos inferiores; 4º) observou-se aumento de inclinação quando os segundos pré-molares inferiores eram os dentes adjacentes ao espaço protético; e 5º) não foram encontradas correlações significantes entre idade, sexo e reabsorção do rebordo residual. Abstract in english This study observed the prevalence of different types of residual ridge inclination in free-ends of mandibles and reported possible correlative factors that may affect resorption. For this purpose, periapical radiographs and individual data collected from a sample of 64 hemiarches were used. Two rad [...] iographs were taken of each free-end, and tracing was employed to determine the angles formed by the resorption configuration in the area of the 1st mandibular molar. The following conclusions were drawn: 1) the great majority of alveolar ridges were distally descending; 2) the average angle was wider for users of mandibular removable partial dentures; 3) the results obtained suggest that the type of opposing maxillary arch affects the inclination of mandibular ridges; 4) greater inclination was observed when the 2nd bicuspids of the mandible were the abutment teeth; 5) no significant correlation was established between age, sex and residual ridge resorption.

Carlos Gramani, Guedes; Artêmio Luiz, Zanetti; Pedro Paulo, Feltrin.

2004-03-01

52

Analysis of the prevalence of different topographical characteristics of the residual ridge in mandibular free-end arches Análise da prevalência de diferentes características topográficas do rebordo residual em arcos mandibulares com extremidades livres  

Directory of Open Access Journals (Sweden)

Full Text Available This study observed the prevalence of different types of residual ridge inclination in free-ends of mandibles and reported possible correlative factors that may affect resorption. For this purpose, periapical radiographs and individual data collected from a sample of 64 hemiarches were used. Two radiographs were taken of each free-end, and tracing was employed to determine the angles formed by the resorption configuration in the area of the 1st mandibular molar. The following conclusions were drawn: 1 the great majority of alveolar ridges were distally descending; 2 the average angle was wider for users of mandibular removable partial dentures; 3 the results obtained suggest that the type of opposing maxillary arch affects the inclination of mandibular ridges; 4 greater inclination was observed when the 2nd bicuspids of the mandible were the abutment teeth; 5 no significant correlation was established between age, sex and residual ridge resorption.Esta pesquisa constatou a prevalência dos tipos de rebordos residuais no sentido ântero-posterior em extremidades livres inferiores, além de correlacionar alguns fatores que possam influenciar as suas reabsorções. Para isso, utilizamos radiografias periapicais e dados individuais colhidos na amostra de 64 hemiarcos; foram obtidas 2 radiografias de cada área de extremidade livre e, a partir de traçados, determinamos os ângulos formados pela reabsorção na altura do 1º molar inferior. Podemos constatar que: 1º a grande maioria de inclinação encontrada foi de rebordos descendentes para distal; 2º a média de angulação foi maior para usuários de prótese parcial removível inferior; 3º os resultados sugeriram existir influência do tipo de arco antagônico superior na inclinação dos rebordos inferiores; 4º observou-se aumento de inclinação quando os segundos pré-molares inferiores eram os dentes adjacentes ao espaço protético; e 5º não foram encontradas correlações significantes entre idade, sexo e reabsorção do rebordo residual.

Carlos Gramani Guedes

2004-03-01

53

Low-dose doxycycline prevents inflammatory bone resorption in rats  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Matrix metalloproteinases (MMP) are considered to be key initiators of collagen degradation, thus contributing to bone resorption in inflammatory diseases. We determined whether subantimicrobial doses of doxycycline (DX) ([...] n experimental periodontitis model. Thirty male Wistar rats (180-200 g) were subjected to placement of a nylon thread ligature around the maxillary molars and sacrificed after 7 days. Alveolar bone loss (ABL) was measured macroscopically in one hemiarcade and the contralateral hemiarcade was processed for histopathologic analysis. Groups of six animals each were treated with DX (2.5, 5 or 10 mg kg-1 day-1, sc, 7 days) and compared to nontreated (NT) rats. NT rats displayed significant ABL, severe mononuclear cell influx and increase in osteoclast numbers, which were significantly reduced by 5 or 10 mg kg-1 day-1 DX. These data show that DX inhibits inflammatory bone resorption in a manner that is independent of its antimicrobial properties.

M.M., Bezerra; G.A.C., Brito; R.A., Ribeiro; F.A.C., Rocha.

2002-05-01

54

On radionuclide resorption from the gastrointestinal tract  

International Nuclear Information System (INIS)

In experiments with rats a study was made of a number of factors influencing the resorption of 241Am from the gastrointestinal tract (GIT). The resorption of 241Am from GIT was found to be 120-245 times more intensive in neonatal rats, during the first 21 days after birth (a milk diet), than in adult animals. A milk diet for adult rats produced a 5-fold increase in the resorption of 241Am from GIT. The additional administration of digestive enzymes, as a homogenate from pancreas and small intestine, produced a 7-9-fold increase in the rate of 241Am resorption from GIT

55

Pulmonary alveolar proteinosis  

Directory of Open Access Journals (Sweden)

Full Text Available Pulmonary alveolar proteinosis (PAP is a rare pulmonary disease characterised by alveolar accumulation of surfactant. It may result from mutations in surfactant proteins or granulocyte macrophage-colony stimulating factor (GM-CSF receptor genes, it may be secondary to toxic inhalation or haematological disorders, or it may be auto-immune, with anti-GM-CSF antibodies blocking activation of alveolar macrophages. Auto-immune alveolar proteinosis is the most frequent form of PAP, representing 90% of cases. Although not specific, high-resolution computed tomography shows a characteristic “crazy paving” pattern. In most cases, bronchoalveolar lavage findings establish the diagnosis. Whole lung lavage is the most effective therapy, especially for auto-immune disease. Novel therapies targeting alveolar macrophages (recombinant GM-CSF therapy or anti-GM-CSF antibodies (rituximab and plasmapheresis are being investigated. Our knowledge of the pathophysiology of PAP has improved in the past 20 yrs, but therapy for PAP still needs improvement.

B. Crestani

2011-06-01

56

The effect of central incisor's root proximity to the cortical plate and apical root resorption in extraction and non-extraction treatment  

Science.gov (United States)

Aims: The present study was conducted to investigate the relevance of cortical plate proximity of maxillary central incisor root, maxillary alveolar bone width, and the apical root resorption in extraction and non-extraction orthodontically treated cases. Further, the correlation between the apical root resorption and the various parameters was investigated. Materials and Methods: A total of 80 lateral head cephalographs, 40 pre-treatment and 40 post-treatment, of orthodontic subjects with a mean age of 15 years treated with fixed standard edgewise appliance were obtained. All subjects were divided into two groups as extraction and non-extraction cases. Twelve linear and three angular parameters were measured and evaluated. The paired “t”-test, Pearson's correlation coefficient, and the stepwise regression analysis were done to test the relationship between the apical root resorption and the various parameters. Results and Conclusions: The study revealed slightly greater amount of apical root resorption in extraction subjects as compared to non-extraction subjects. However, no statistically significant difference was found between the two treatment modalities. In extraction subjects, the apical root resorption was directly proportional to the pre-treatment length of maxillary central incisor and inversely proportional to the root width in apical one-third region, though there was a weak correlation. In non-extraction subjects, the pre-treatment anteroposterior position of the root apex of maxillary central incisor in the alveolar bone, in combination with its root width in the apical one-third region formed the predictive factors for the variance in the amount of the apical root resorption, though there was a weak correlation. Furthermore, the changes in the alveolar widths at the root apex and mid-root region were considered as predictive factors for the amount of apical root resorption during extraction and non-extraction treatment, respectively. PMID:24987663

Agarwal, Akhil; Sharma, Vijay P; Singh, Gulshan K; Tikku, Tripti; Agarwal, Nidhi; Mengi, Arvind

2014-01-01

57

Alveolar process reconstruction after tooth extraction by orthodontic indications  

Directory of Open Access Journals (Sweden)

Full Text Available The objective of the study is to determine indications for alveolar bone reconstruction after tooth extraction according to orthodontic indications. Material and methods. 62 patients (first maturity level with dental arch asymmetry due to loss of a premolar on one side of the mouth were examined and treated. Frontal-diagonal coefficient of the dental arch was used to determine the correlation between tooth size and dental arch parameters. Results. It has been demonstrated that changes of the alveolar ridge following the extraction of the first premolars in patients of the experimental group were less significant as compared with the controls. Conclusion. It is reasonable to apply this method simultaneously with the removal of a tooth for orthodontic indications or when the alveolar ridge in the post-extraction socket leaves insufficient bone volume.

Kovalev ?.?.

2013-09-01

58

Crown amputation with intentional root retention for advanced feline resorptive lesions--a clinical study.  

Science.gov (United States)

Whole tooth extraction is generally considered to be the treatment of choice for teeth with advanced feline external odontoclastic resorptive lesions. These teeth often have both a weakened, brittle crown and radicular ankylosis. These two factors cause frustration and sometimes complications during attempts at extraction. This study investigated the alternative of intentionally leaving part or all of non-pathologic tooth roots in situ to prevent iatrogenic trauma to the patient, loss of alveolar bone, and prolonged healing of surgical defects. Fifty one roots from 23 teeth were radiographed 5-36 months following elective root retention; continued resorption without surrounding bony reaction was seen in almost all cases. In one cat, the roots retained normal periodontal ligament one year later, and in another cat that developed severe stomatitis, the intentionally retained roots were extracted at the same time that the remaining molar teeth were extracted. PMID:9693619

DuPont, G

1995-03-01

59

Dry Socket (Alveolar Osteitis)  

Science.gov (United States)

Dry Socket (Alveolar Osteitis) What Is It? Symptoms Diagnosis Expected Duration Prevention Treatment When To Call a Professional Prognosis Additional Info What Is It? Dry socket is a problem that can occur after you ...

60

Microlitiasis alveolar pulmonar Pulmonary alveolar microlithiasis  

Directory of Open Access Journals (Sweden)

Full Text Available La microlitiasis alveolar pulmonar (MAP es una enfermedad rara caracterizada por la presencia difusa y bilateral de microlitos de fosfato de calcio en el interior de los espacios alveolares. La progresión de esta enfermedad potencialmente letal, es lenta y la mayoría de los pacientes permanecen asintomáticos por años o décadas, resultando en deterioro lento de sus funciones pulmonares. El hallazgo de la radiografía de tórax en "tormenta de arena" es característico de la entidad. Recientemente se identificaron mutaciones en el gen SLC34A2, que codifica para el cotransportador tipo IIb de fosfato sódico, como responsable de la enfermedad. De los casi 600 casos, sólo seis han sido reportados en Colombia. Nosotros presentamos un caso de microlitiasis alveolar pulmonar en un hombre de 27 años, con dificultad respiratoria progresiva, cuyo diagnóstico se hizo por los hallazgos radiográficos y se confirmó por biopsia transbronquial. En el seguimiento durante dos años, evolucionó hacia el deterioro de su función respiratoria y es candidato a trasplante de pulmón.Pulmonary alveolar microlithiasis (PAM is a rare disease characterized by the diffuse and bilateral presence of calcium phosphate microlite in the alveolar spaces. The progression of this potentially lethal disease is show and most of the patients remain asymptomatic during years or decades, resulting in a show deterioration of the pulmonary function. The typical finding of the "sand storm" in the chest X-ray is characteristic of this entity. Mutations in the SLC34A2 gene that does the coding for the type II co-transporter of sodium phosphate were identified as responsible for this disease. Of the almost 600 cases, only 6 have been reported in Colombia. We are presenting a case of pulmonary alveolar microlite in a 27 year old man, with progressive respiratory distress whose diagnosis was made by the X-ray findings and confirmed by trans bronchial biopsy. In the 2 years follow-up, shows evolution towards deterioration of his respiratory function making him a candidate for lung transplantation.

Franco Javier Vallejo García

2007-12-01

61

Microlitiasis alveolar pulmonar / Pulmonary alveolar microlithiasis  

Scientific Electronic Library Online (English)

Full Text Available SciELO Colombia | Language: Spanish Abstract in spanish La microlitiasis alveolar pulmonar (MAP) es una enfermedad rara caracterizada por la presencia difusa y bilateral de microlitos de fosfato de calcio en el interior de los espacios alveolares. La progresión de esta enfermedad potencialmente letal, es lenta y la mayoría de los pacientes permanecen asi [...] ntomáticos por años o décadas, resultando en deterioro lento de sus funciones pulmonares. El hallazgo de la radiografía de tórax en "tormenta de arena" es característico de la entidad. Recientemente se identificaron mutaciones en el gen SLC34A2, que codifica para el cotransportador tipo IIb de fosfato sódico, como responsable de la enfermedad. De los casi 600 casos, sólo seis han sido reportados en Colombia. Nosotros presentamos un caso de microlitiasis alveolar pulmonar en un hombre de 27 años, con dificultad respiratoria progresiva, cuyo diagnóstico se hizo por los hallazgos radiográficos y se confirmó por biopsia transbronquial. En el seguimiento durante dos años, evolucionó hacia el deterioro de su función respiratoria y es candidato a trasplante de pulmón. Abstract in english Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by the diffuse and bilateral presence of calcium phosphate microlite in the alveolar spaces. The progression of this potentially lethal disease is show and most of the patients remain asymptomatic during years or decades, result [...] ing in a show deterioration of the pulmonary function. The typical finding of the "sand storm" in the chest X-ray is characteristic of this entity. Mutations in the SLC34A2 gene that does the coding for the type II co-transporter of sodium phosphate were identified as responsible for this disease. Of the almost 600 cases, only 6 have been reported in Colombia. We are presenting a case of pulmonary alveolar microlite in a 27 year old man, with progressive respiratory distress whose diagnosis was made by the X-ray findings and confirmed by trans bronchial biopsy. In the 2 years follow-up, shows evolution towards deterioration of his respiratory function making him a candidate for lung transplantation.

Franco Javier, Vallejo García; Alejandro, Vallejo García; Maximiliano, Parra.

2007-12-01

62

Beneficial role of periosteum in distraction osteogenesis of mandible. Its preservation prevents the external bone resorption  

International Nuclear Information System (INIS)

Distraction osteogenesis (DO) is a surgical process of new bone generation through the gradual extension of two segments of existing bone. DO is applied for maxillofacial surgeries to manage defects in mandibular continuity. Vertical DO with an oral device is often employed to augment the alveolar bone height for better implant anchorage for esthetic purposes or functional prosthetic requirements. To determine how the periosteum affects the vertical DO in mandibular reconstruction, we extracted the teeth and resected the alveolar parts of the mandible on both sides of dogs, along with removal of the surrounding periosteum in the right, but not left side. Three months later, box-shaped bone segments (vectors) were prepared from the resected alveolar part, and the segments were vertically elongated using a distraction device on both sides at 0.9 mm/day for one week. The extent of bone formation after distraction was determined with micro-focused computed tomography and by measuring incorporation of tetracycline and calcein with confocal laser scanning microscopy. During the initial two months after distraction, new bone formation was observed more prominently in the left side than in the right side of mandible with the periosteum. However, this difference was less clear during the bone-remodeling period. One notable change was the reduced height of the alveolar part of the right-side mandible, a sign of external bone resorption, observed in two out of three dogs at 6-mo observed in two out of three dogs at 6-month post-consolidation. These findings suggest that preservation of periosteum prevents the external bone resorption during the vertical DO of mandible. (author)

63

Roles of hyaluronan in bone resorption  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Hyaluronan, an unsulfated glycosaminoglycan, while being closely linked to osteoclast function several years ago, has received little attention lately. Given recent new knowledge of hyaluronan's possible cell binding abilities, it is important to re-examine the role of this polysaccharide in bone homeostasis. Discussion Previously published data demonstrating a linkage between induction of hyaluronan synthesis and osteoclast-mediated bone resorption are reviewed. Suggestions are made involving the cell binding ability of hyaluronan and its potential to mediate osteoclast binding to bone surfaces and its potential to serve as a diffusion barrier and participate in the sealing zone required for osteoclast-mediated bone resorption. Summary This brief article summarizes previous studies linking HA to bone resorption and suggests roles for hyaluronan in the process of bone resorption.

Prince Charles W

2004-04-01

64

Congenital Pulmonary Alveolar Proteinosis  

OpenAIRE

Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by pulmonary surfactant accumulation within the alveolar spaces. It occurs with a reported prevalence of 0.1 per 100,000 individuals. Two clinically different pediatric types have been defined as congenital PAP which is fatal and a late-onset PAP which is similar to the adult form and less severe. The clinical course of PAP is variable, ranging from spontaneous remission to respiratory failure. Whole-lung lavage is the curr...

Saber Hammami; Khaled Harrathi; Khaled Lajmi; Samir Hadded; Chebil Ben Meriem; Amp Xe Ji Gu Amp Xe Diche, Mohamed N.

2013-01-01

65

Diffuse Alveolar Hemorrhage  

OpenAIRE

Diffuse alveolar hemorrhage (DAH) is a life-threatening and medical emergency that can be caused by numerous disorders and presents with hemoptysis, anemia, and diffuse alveolar infiltrates. Early bronchoscopy with bronchoalveolar lavage is usually required to confirm the diagnosis and rule out infection. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as anti-neutrophil cytoplasmic antibody-associated vasculitis, anti-glomerular basement membran...

Park, Moo Suk

2013-01-01

66

Predisposing factors to severe external root resorption associated to orthodontic treatment  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: avaliar os fatores comuns aos pacientes que desenvolveram reabsorção radicular externa moderada ou severa (graus 3 e 4 de Malmgren) nos incisivos superiores, durante o tratamento ortodôntico fixo na dentição permanente. MÉTODOS: foram selecionados 99 pacientes que iniciaram o tratamento or [...] todôntico fixo com a técnica Edgewise. Os pacientes foram divididos em dois grupos: G1 - 50 pacientes que concluíram o tratamento com ausência de reabsorções radiculares ou apresentando apenas irregularidades apicais (graus 0 e 1 de Malmgren), com idade média inicial de 16,79 anos e tempo de tratamento médio de 3,21 anos; G2 - 49 pacientes que finalizaram o tratamento apresentando reabsorção radicular moderada ou severa (graus 3 e 4 de Malmgren) nos incisivos superiores, com idade média inicial de 19,92 anos e tempo de tratamento médio de 3,98 anos. As radiografias periapicais e telerradiografias foram avaliadas, além de diversos fatores que pudessem influenciar a ocorrência de uma reabsorção severa. A análise estatística incluiu o testes qui-quadrado, teste exato de Fisher e teste t independente. RESULTADOS: foi demonstrada a presença de diferença significativa entre os grupos para as variáveis realização de extrações, grau de reabsorção radicular inicial, comprimento radicular, proporção coroa/raiz e da espessura da cortical óssea alveolar. CONCLUSÃO: pode-se concluir que são fatores de risco para reabsorção radicular severa nos incisivos superiores, durante o tratamento ortodôntico, a presença de reabsorção radicular antes do início do tratamento, a realização de extrações, o comprimento radicular reduzido, a proporção coroa/raiz diminuída e a espessura óssea alveolar fina. Abstract in english OBJECTIVE: The aim of this study was to evaluate predisposing factors among patients who developed moderate or severe external root resorption (Malmgren's grades 3 and 4), on the maxillary incisors, during fixed orthodontic treatment in the permanent dentition. METHODS: Ninety-nine patients who unde [...] rwent orthodontic treatment with fixed edgewise appliances were selected. Patients were divided into two groups: G1 - 50 patients with no root resorption or presenting only apical irregularities (Malmgren's grades 0 and 1) at the end of the treatment, with mean initial age of 16.79 years and mean treatment time of 3.21 years; G2 - 49 patients presenting moderate or severe root resorption (Malmgren's grades 3 and 4) at the end of treatment on the maxillary incisors, with mean initial age of 19.92 years and mean treatment time of 3.98 years. Periapical radiographs and lateral cephalograms were evaluated. Factors that could influence the occurrence of severe root resorption were also recorded. Statistical analysis included chi-square tests, Fisher's exact test and independent t tests. RESULTS: The results demonstrated significant difference between the groups for the variables: Extractions, initial degree of root resorption, root length and crown/root ratio at the beginning, and cortical thickness of the alveolar bone. CONCLUSION: It can be concluded that: Presence of root resorption before the beginning of treatment, extractions, reduced root length, decreased crown/root ratio and thin alveolar bone represent risk factors for severe root resorption in maxillary incisors during orthodontic treatment.

Gracemia Vasconcelos, Picanço; Karina Maria Salvatore de, Freitas; Rodrigo Hermont, Cançado; Fabricio Pinelli, Valarelli; Paulo Roberto Barroso, Picanço; Camila Pontes, Feijão.

2013-02-01

67

The relevance of leukotrienes for bone resorption induced by mechanical loading.  

Science.gov (United States)

5-Lipoxygenase (5-LO) metabolites are important pro-inflammatory lipid mediators. However, much still remains to be understood about the role of such mediators in bone remodeling. This study aimed to investigate the effect of 5-LO metabolites, LTB4 and CysLTs, in a model of mechanical loading-induced bone remodeling. Strain-induced tooth movement and consequently alveolar bone resorption/apposition was achieved by using a coil spring placed on molar and attached to incisors of C57BL6 (wild-type-WT), 5-LO deficient mice (5-LO(-/-)) and mice treated with 5-LO inhibitor (zileuton-ZN) or with antagonist of CysLTs receptor (montelukast-MT). The amount of bone resorption and the number of osteoclasts were determined morphometrically. The expression of inflammatory and bone remodeling markers in periodontium was analyzed by qPCR. Osteoclast differentiation and TNF-? production were evaluated in vitro using RAW 264.7 cells treated with LTB4 or LTD4. Bone resorption, TRAP(+) cells and expression of Tnfa, Il10 and Runx2 were significantly diminished in 5-LO(-/-), ZN- and MT-treated mice. The expression of Rank was also reduced in 5-LO(-/-) and MT-treated mice. Accordingly, LTB4 and LTD4 in association with RANKL promoted osteoclast differentiation and increased TNF-? release in vitro. These data demonstrate that the absence of 5-LO metabolites, LTB4 and CysLTs reduces osteoclast recruitment and differentiation, consequently diminishing bone resorption induced by mechanical loading. Thus, 5-LO might be a potential target for controlling bone resorption in physiological and pathological conditions. PMID:25270168

Moura, A P; Taddei, S R A; Queiroz-Junior, C M; Madeira, M F M; Rodrigues, L F D; Garlet, G P; Souza, D G; Machado, F S; Andrade, I; Teixeira, M M; Silva, T A

2014-12-01

68

[Effect of the diet with different microelement composition on the state of alveolar and pelvic bones in rats].  

Science.gov (United States)

During this experimental study with 6 week-old rats the rate of alveolar bone resorption increased with the balanced diet and drinking water containing 50 mg/l NaF, which is similar to the group of rats observed in case of periodontitis model with the same diet and supplemented with ammonium chloride 5 mg/kg. The mineral complex (Mg-sulfat, Zn-sulfat, Mr-sulfat, Na-citrat) 300 mg/kg possessing a pronounced anti acidosis effect when added to the same balanced diet and sodium fluoride in drinking water with the same concentration prevents resorption processes in the alveolar bone and reduces toxicity action of fluorides on the alveolar and pelvic bones by decreasing metabolic acidosis in the bone tissue. PMID:18416188

Biloklyts'ka, H F; Pohrebniak, H V; Khalili, Dzhafar

2008-01-01

69

Correction of bone and softtissue deformity of the single implant in the aesthetic zone: a case treated with alveolar ridge preservation, modified roll technique and a digitally coded healing abutment.  

Science.gov (United States)

The correction of soft tissue deformity and aesthetic rehabilitation of a single implant in the aesthetic zone with a combination of periodontal and prosthodontic approaches is described. Soft tissue deformity was corrected resulting in significant soft tissue volume increase and eliminated the need for prosthetic gingival replacement. A two stage implant placement protocol, ridge preservation and a soft tissue augmentation flap design preserved epithelium attachment to the connective tissues. Use of a digitally coded healing abutment preserved the newly established soft tissue volume, allowed impression making without implant component removal, and minimized trauma to the newly established soft tissue architecture. PMID:25134361

Dhima, M

2014-06-01

70

Equine odontoclastic tooth resorption and hypercementosis.  

Science.gov (United States)

A poorly described, painful disorder of incisor and canine teeth, variably causing periodontitis, with resorptive or proliferative changes of the calcified dental tissues, has recently been documented in aged horses. No plausible aetiopathogenesis for this syndrome has been recorded. Eighteen diseased teeth from eight horses were examined grossly and microscopically and showed the presence of odontoclastic cells by tartrate resistant acid phosphatase (TRAP) staining. A chronological sequence of odontoclastic resorption followed by hypercementosis was demonstrated and, consequently, the term equine odontoclastic tooth resorption and hypercementosis (EOTRH) is proposed for this disorder. EOTRH shares many features with similar dental syndromes described in humans and cats. An aetiological hypothesis proposes mechanical stress of the periodontal ligament as the initiating factor. PMID:19010701

Staszyk, Carsten; Bienert, Astrid; Kreutzer, Robert; Wohlsein, Peter; Simhofer, Hubert

2008-12-01

71

Measuring mandibular ridge reduction  

International Nuclear Information System (INIS)

This thesis investigates the mandibular reduction in height of complete denture wearers and overdenture wearers. To follow this reduction in the anterior region as well as in the lateral sections of the mandible, an accurate and reproducible measuring method is a prerequisite. A radiologic technique offers the best chance. A survey is given of the literature concerning the resorption process after the extraction of teeth. An oblique cephalometric radiographic technique is introduced as a promising method to measure mandibular ridge reduction. The reproducibility and the accuracy of the technique are determined. The reproducibility in the positioning of the mandible is improved by the introduction of a mandibular support which permits a precise repositioning of the edentulous jaw, even after long periods of investigation. (Auth.)

72

Alveolar soft part sarcoma  

International Nuclear Information System (INIS)

We report a case of alveolar soft part sarcoma (ASPS) of the thigh with lung metastases in a 22-year-old woman. The findings of digital subtraction angiography (DSA) and MRI contributed to the diagnosis of ASPS. Especially dynamic contrast-enhanced MRI was useful for evaluating the effect of chemoembolotherapy. (orig.)

73

Alveolar soft part sarcoma  

Energy Technology Data Exchange (ETDEWEB)

We report a case of alveolar soft part sarcoma (ASPS) of the thigh with lung metastases in a 22-year-old woman. The findings of digital subtraction angiography (DSA) and MRI contributed to the diagnosis of ASPS. Especially dynamic contrast-enhanced MRI was useful for evaluating the effect of chemoembolotherapy. (orig.) With 5 figs., 23 refs.

Nakanishi, K.; Nakamura, H. [Department of Radiology, Osaka University Medical School, 2-2 Yamadaoka, Suita-City, Osaka 565 (Japan); Araki, N. [Department of Orthopaedic Surgery, Osaka University Medical School, 2-2 Yamadaoka, Suita-City, Osaka 565 (Japan); Yoshikawa, H. [Department of Orthopaedic Surgery, Center for Adult Disease, Osaka (Japan); Hashimoto, T. [Department of Radiology, Osaka Rosai Hospital, Osaka (Japan)

1998-06-02

74

[Pulmonary alveolar proteinosis].  

Science.gov (United States)

Alveolar proteinosis (AP) is a rare disease characterized by alveolar accumulation of surfactant components, which impairs gas exchange. AP is classified into three groups: auto-immune AP defined by the presence of plasma autoantibodies anti-GM-CSF, the most frequent form (90% of all AP); secondary AP, mainly occurring as a consequence of haematological diseases, or following on from toxic inhalation or infections, and genetic AP, which affects almost exclusively children. AP diagnosis is suspected where chest CT-scan demonstrates interstitial lung disease with a crazy paving aspect; and confirmed by bronchoalveolar lavage, which has a milky appearance and contains periodic acid Schiff positive proteinaceous alveolar deposits. The use of surgical lung biopsy to confirm AP is less frequent nowadays. In this context, positive antibodies against GM-CSF indicates an auto-immune etiology of the AP. Concerning management, whole lung lavage is the gold standard therapy. In refractory AP, new treatments are available such as subcutaneous or inhaled GM-CSF supplementation, or rituximab infusions. The clinical course is unpredictable. Spontaneous improvement or even cure can occur, and the 5-year actuarial survival is 95%. The most frequent complications are infectious etiology. PMID:25496792

Jouneau, S; Kerjouan, M; Briens, E; Lenormand, J-P; Meunier, C; Letheulle, J; Chiforeanu, D; Lainé-Caroff, C; Desrues, B; Delaval, P

2014-12-01

75

The bone splitting stabilisation technique--a modified approach to prevent bone resorption of the buccal wall.  

Science.gov (United States)

The aim of this case series was to clinically demonstrate successful prevention of bone resorption of the buccal wall after alveolar bone splitting by additional stabilization of the lateral bone plate using a biphasic ceramic bone substitute. In three patients alveolar bone splitting was performed with a piezoelectric device. Clinical as well as radiological results after two and five years revealed stable hard and soft tissue conditions with no soft tissue recessions and peri-implant bone loss in three patients. The advantage of this one-stage procedure was the ability to insert dental implants into a very compromised bony site in a simultaneous procedure. Yet the bone splitting stabilisation technique appeared to be a more user-sensitive method. PMID:25284573

Stricker, Andres; Stübinger, Stefan; Voss, Pit; Duttenhoefer, Fabian; Fleiner, Jonathan

2014-09-01

76

TDAG8 activation inhibits osteoclastic bone resorption.  

Science.gov (United States)

Although the roles of acids in bone metabolism are well characterized, the function of proton-sensing receptors in bone metabolism remains to be explored. In this study, we evaluated the role of proton-sensing receptor T-cell death-associated gene 8 (TDAG8) in osteoclastic activity during bone loss after ovariectomy. Through observations of bone mineral content, we found that pathological bone resorption was significantly exacerbated in mice homozygous for a gene trap mutation in the Tdag8 gene. Furthermore, osteoclasts from the homozygous mutant mice resorbed calcium in vitro more than the osteoclasts from the heterozygous mice did. Impaired osteoclast formation under acidic conditions was ameliorated in cultures of bone marrow cells by Tdag8 gene mutation. Extracellular acidification changed the cell morphology of osteoclasts via the TDAG8-Rho signaling pathway. These results suggest that the enhancement of TDAG8 function represents a new strategy for preventing bone resorption diseases, such as osteoporosis. PMID:24221084

Hikiji, Hisako; Endo, Daisuke; Horie, Kyoji; Harayama, Takeshi; Akahoshi, Noriyuki; Igarashi, Hidemitsu; Kihara, Yasuyuki; Yanagida, Keisuke; Takeda, Junji; Koji, Takehiko; Shimizu, Takao; Ishii, Satoshi

2014-02-01

77

Multiple Congenital Epulis of the Mandibular Ridge: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Congenital epulis is a very rare benign soft-tissue tumor of uncertain histogenesis, which is also known as “gingival granular cell tumor of the newborn”. It occurs almost exclusively as a single tumor along the alveolar ridge of the maxilla in newborn females. Although congenital epulis is strikingly similar to the more common adult granular cell tumor histologically, in contrast to the latter congenital epulis cells are negative for S-100 protein. This case report describes a 15-day-old female infant with multiple congenital epulis of the mandibular alveolar ridge.

Mohammad Gharavi

2011-01-01

78

Pyogenic granuloma of unusual size with alveolar resorption in a 75-year-old patient  

OpenAIRE

Pyogenic granuloma is an overzealously proliferative non-neoplastic lesion of connective tissue origin, found commonly in oral cavity and is secondary to chronic low grade local irritation, poor oral hygiene, and hormonal disturbances. The term is misnomer because a lesion is unrelated to infection. It is characterized by excessive and exuberant tissue repair response with varied inflammatory component. Since it is a benign lesion, choice of treatment is surgical excision with removal of unde...

Shaikh, Shoyeb; Singh, Gaurav; Singh, Anil; Gaur, Amit

2012-01-01

79

Alveolar soft part sarcoma.  

Science.gov (United States)

Alveolar soft part sarcoma (ASPS) is a rare form of soft tissue sarcoma and is most often seen in adolescents and young adults. Despite its unique histology and well-characterised genetic translocation, many questions remain regarding the pathogenesis and treatment of this tumour type. Surgical excision of the primary tumour and pulmonary metastases has resulted in prolonged survival of some patients while the benefit of adjuvant chemotherapy and/or radiotherapy has been disputed. A 35-year-old woman presented with a tumour in the right leg and right side of the mandible along with active metastasis to lungs and multiple skeletal sites. PMID:24722715

Singh, Aarti; Gupta, Sunita; Ghosh, Sujoy; Yuwanati, Monal Bhaurao

2014-01-01

80

Multiple Idiopathic Apical Root Resorption: a Case Report  

OpenAIRE

The aim of this case report was to present a case of multiple idiopathic apical root resorption which is a rare condition in a 17-year-old adult male. External root resorption of the permanent teeth is a multifactorial process. Well-recognized causes of apical root resorption in permanent teeth include orthodontic therapy, trauma, periapical or periodontal inflammation, tumors, cysts, occlusal stress, impacted teeth, systemic conditions, endocrine imbalances and dietary habits. When none of t...

Khojastepour, L.; Bronoosh, P.; Azar, M.

2010-01-01

81

Low-dose doxycycline prevents inflammatory bone resorption in rats  

OpenAIRE

Matrix metalloproteinases (MMP) are considered to be key initiators of collagen degradation, thus contributing to bone resorption in inflammatory diseases. We determined whether subantimicrobial doses of doxycycline (DX) (

Bezerra, M. M.; Brito, G. A. C.; Ribeiro, R. A.; Rocha, F. A. C.

2002-01-01

82

Acidification of the Osteoclastic Resorption Compartment Provides Insight into the Coupling of Bone Formation to Bone Resorption  

OpenAIRE

Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and that impairment of acidification results in inhibition of bone resorption without inhibition of bone formation. We investigated the role of acidification in human osteoclastic resorption and life span in vitro using inhibitors of chloride channels ...

Karsdal, Morten A.; Henriksen, Kim; Sørensen, Mette G.; Gram, Jeppe; Schaller, Sophie; Dziegiel, Morten H.; Heegaard, Anne-marie; Christophersen, Palle; Martin, Thomas J.; Christiansen, Claus; Bollerslev, Jens

2005-01-01

83

Alveolar soft-part sarcoma  

Energy Technology Data Exchange (ETDEWEB)

Alveolar soft-part sarcoma usually arises from the soft tissue of the lower extremity, but may arise from the orbit, retroperitoneum and else where, in both children and adults. The tumors grow slowly, may invade the underlying bone, and eventually may metastasis widely through the blood stream. Recently, we experienced 5 cases of alveolar soft-part sarcoma originated from thigh, lower leg, inguinal region, retroperitoneum and orbit. The radiologic findings are soft tissue mass (2 cases) with underlying bony destruction (3 cases), lung metastasis (2 cases). Although rare, alveolar soft-part sarcoma should be included in the differential diagnosis of soft tissue tumor arising from the lower extremity.

Jung, Seung Hyae; Sung, Dong Wook; Yoon, Yup; Choi, Woo Suk; Lim, Jae Hoon; Yang, Moon Ho [College of Medicine, Kyunghee Univ., Seoul (Korea, Republic of)

1990-10-15

84

Alveolar soft-part sarcoma  

International Nuclear Information System (INIS)

Alveolar soft-part sarcoma usually arises from the soft tissue of the lower extremity, but may arise from the orbit, retroperitoneum and else where, in both children and adults. The tumors grow slowly, may invade the underlying bone, and eventually may metastasis widely through the blood stream. Recently, we experienced 5 cases of alveolar soft-part sarcoma originated from thigh, lower leg, inguinal region, retroperitoneum and orbit. The radiologic findings are soft tissue mass (2 cases) with underlying bony destruction (3 cases), lung metastasis (2 cases). Although rare, alveolar soft-part sarcoma should be included in the differential diagnosis of soft tissue tumor arising from the lower extremity

85

Oral malodor associated with internal resorption.  

Science.gov (United States)

We report a case of oral malodor associated with internal resorption. A 39-year-old male attended our hospital complaining of oral malodor. Utilizing organoleptic measurement, the halimeter test and gas chromatography, it was diagnosed as a strong halitosis caused by oral origin. The pocket probing depth of tooth 21 was 10 mm, and X-ray examination revealed a vertical bone loss around this tooth. The patient had received periodontal treatment at two dental offices previously, but the periodontal conditions and oral malodor persisted. We performed an initial periodontal preparation, however a deep pocket remained. We therefore performed a surgical inspection including flap reflection, and found that the tooth had a large perforating defect in the distal surface. The extracted tooth had multiple perforating defects covered with granulation tissues on all root surfaces including the root apex. Taking into consideration the anamnesis and X-ray examination of the extracted tooth, internal absorption was considered to have been the cause of the multiple perforating defects. After extraction of the causative tooth, oral malodor dramatically decreased. To our knowledge, this is the first report of an oral malodor associated with internal resorption. PMID:16858138

Yoneda, Masahiro; Naito, Toru; Suzuki, Nao; Yoshikane, Toru; Hirofuji, Takao

2006-06-01

86

Alveolar proteinosis in Behçet's disease  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract A 51-year-old man with Behçet's disease complained of fever, dry cough and dyspnea during exertion. Chest CT showed ground glass opacities with interstitial septal thickening in both lungs. Bronchoalveolar lavage (BAL revealed amorphous and lipoproteinaceous material that was periodic acid-Schiff (PAS stain positive. Transbronchial biopsy specimen demonstrated PAS positive alveolar eosinophilic material consistent with pulmonary alveolar proteinosis. Serum anti-granulocyte-macrophage colony stimulating factor (GM-CSF antibody was negative. Recent studies have reported anti-GMCSF not present in the the serum of patients with secondary pulmonary alveolar proteinosis (PAP but they have not reported so in patients with idiopathic PAP. We report a case of alveolar proteinosis in the setting of Behçet's disease with spontaneous remission.

Tetikkurt Cuneyt

2010-08-01

87

Feline odontoclastic resorptive lesions: unveiling the early lesion.  

Science.gov (United States)

The purpose of this study was to increase understanding of the factors initiating feline odontoclastic resorptive lesions (FORLs). Fifty-six teeth (clinically and radiographically unaffected by ORLs) were harvested. Of these, 43 were from cats that had ORLs in other teeth (group A) and 13 were from cats with no clinical or radiographic evidence of ORLs in any teeth (group B). Twenty-six teeth in group A and one tooth in group B showed histological evidence of external root resorption (surface resorption and replacement resorption resulting in ankylosis). Some teeth in group B showed healed cementum resorption. It has previously been assumed that FORLs were similar to lesions associated with peripheral inflammatory root resorption, and were associated with periodontal disease. These histological findings suggest instead that a FORL is a non-inflammatory replacement resorption, resulting in ankylosis. The periodontal ligament of resorbing teeth lacked normal fibrous architecture, but was not inflamed. Resorption was not identified in cervical cementum. However, the histological appearance of the cervical cementum differed between the two groups. Several aetiopathogenetic explanatory models which arise from these observations are discussed. PMID:12463263

Gorrel, C; Larsson, A

2002-11-01

88

Alveolar proteinosis in Behçet's disease  

OpenAIRE

Abstract A 51-year-old man with Behçet's disease complained of fever, dry cough and dyspnea during exertion. Chest CT showed ground glass opacities with interstitial septal thickening in both lungs. Bronchoalveolar lavage (BAL) revealed amorphous and lipoproteinaceous material that was periodic acid-Schiff (PAS) stain positive. Transbronchial biopsy specimen demonstrated PAS positive alveolar eosinophilic material consistent with pulmonary alveolar proteinosis. Serum anti-granulocyte-macroph...

Tetikkurt Cuneyt; Tetikkurt Seza; Ozdemir Imran; Zuhur Cigdem; Bayar Nihal

2010-01-01

89

Post-extraction application of beta-tricalcium phosphate in alveolar socket  

Directory of Open Access Journals (Sweden)

Full Text Available Aim The objective of this study was to assess the capacity of beta-tricalcium phosphate to facilitate bone formation in the socket and prevent post-extraction alveolar resorption. Materials and methods After premolar extraction in 16 patients, the sockets were filled with beta-tricalcium phosphate. Six months later, during the implant placement surgery, a trephine was used to harvest the bone samples which were processed for histological and histomorphometrical analyses. Data were gathered on patient, clinical, histological and histomorphometric variables at the extraction and implant placement sessions, using data collection forms and pathological reports. Results Clinical outcomes were satisfactory, the biomaterial was radio-opaque on X-ray. Histological study showed: partial filling with alveolar bone of appropriate maturation and mineralization for the healing time, osteoblastic activity and bone lacunae containing osteocytes. The biomaterial was not completely resorbed at six months. Conclusion Beta-tricalcium phosphate is a material capable of achieving preservation of the alveolar bone when it is positioned in the immediate post-extraction socket followed by suture; it also helps the formation of new bone in the socket. Further studies are needed comparing this technique with other available biomaterials, with growth factors and with sites where no alveolar preservation techniques are performed.

M. Muñoz-Corcuera

2015-03-01

90

1,25-Dihydroxycholecalciferol increases bone resorption in thyroparathyroidectomised mice.  

Science.gov (United States)

Mice, 1 week old, prelabelled with 45Ca, were either thyroparathyroidectomised or sham-operated; 1 day later half of the mice of each group were injected with 1,25-dihydroxycholecalciferol (5 ng/g), and 20 h later all the mice were killed. Bone resorption in explants was then measured by an in vivo/in vitro technique previously published; compared with untreated mice it was found that 1,25-dihydroxycholecalciferol had increased resorption irrespective of whether the mice had been thyroparathyroidectomised or not. These data suggest that 1,25-dihydroxycholecalciferol is able to increase bone resorption independently of parathyroid hormone. PMID:1000337

Reynolds, J J; Pavlovitch, H; Balsan, S

1976-12-01

91

Multiple idiopathic external apical root resorption: A rare case report.  

Science.gov (United States)

Multiple idiopathic external apical root resorption (MIEARR) is a relatively rare condition affecting multiple teeth in a dentition. As the condition is nonsymptomatic, a case is usually detected as an incidental radiographic finding. However, it may cause pain and mobility in severe cases. It is sometimes self-limiting or sometimes may progress to tooth loss. This paper presents a case of external apical root resorption involving multiple teeth in which etiology was not identified, so idiopathic root resorption was considered as a diagnosis of exclusion. PMID:25657532

Bansal, Parul; Nikhil, Vineeta; Kapur, Sonali

2015-01-01

92

Novel Role of the Human Alveolar Epithelium in Regulating Intra-Alveolar Coagulation  

OpenAIRE

Intra-alveolar fibrin deposition is a common response to localized and diffuse lung infection and acute lung injury (ALI). We hypothesized that the alveolar epithelium modulates intra-alveolar fibrin deposition through activation of protein C. Our obejctives were to determine whether components of the protein C activation pathway are present in the alveolar compartment in ALI and whether alveolar epithelium is a potential source. In patients with ALI, pulmonary edema fluid levels of endotheli...

Wang, Ling; Bastarache, Julie A.; Wickersham, Nancy; Fang, Xiaohui; Matthay, Michael A.; Ware, Lorraine B.

2006-01-01

93

Multiple Idiopathic Apical Root Resorption: a Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this case report was to present a case of multiple idiopathic apical root resorption which is a rare condition in a 17-year-old adult male. External root resorption of the permanent teeth is a multifactorial process. Well-recognized causes of apical rootresorption in permanent teeth include orthodontic therapy, trauma, periapical or periodontal inflammation, tumors, cysts, occlusal stress, impacted teeth, systemic conditions, endocrine imbalances and dietary habits. When none of these causes are present, it is termed idiopathic root resorption which may be either cervical or apical.Multiple idiopathic apical root resorption is a rare condition which is usually detected as an incidental radiographic finding. However, it may cause pain and mobility in severe cases.

L. Khojastepour

2010-09-01

94

“Internal root resorption: An endodontic challenge”: A case series  

OpenAIRE

Management of internal root resorption is a challenge to the endodontists. It may occur in cases with chronic pulpal inflammation, following caries or due to trauma in the form of an accidental blow. Most cases of internal root resorption are seen in anterior teeth, due to their susceptibility to trauma. However, it may be seen in posterior teeth, most likely because of carious involvement of the pulp. Early diagnosis, removal of the cause, proper treatment of the resorbed root is mandatory f...

Mittal, Sunandan; Kumar, Tarun; Mittal, Shifali; Sharma, Jyotika

2014-01-01

95

Identification of A Novel Root Resorptive Function of Osteopontin Gene  

OpenAIRE

Objective: Osteopontin (OPN) has been proposed to play a role in bone resorption. With regard to bone and cementum/dentin structural and histological similarities, it was hy-pothesized that expression of this gene might be increased in resorptive lacunae during orthodontic tooth movement.Materials and Methods: Fixed Nickel-Titanium closed coil springs (Dentaurum®) capa-ble of delivering approximately 60 gf were applied for mesial movement of maxillary left first molars in 26 male 8-week-old ...

Seifi, M.; Jessri, M.; Vahid-dastjerdi, E.

2008-01-01

96

Inflammatory root resorption in primary molars: prevalence and associated factors  

OpenAIRE

This study aimed at determining the prevalence of inflammatory root resorption and associated factors in 1068 primary mandibular molars in 453 children 3 to 12 years of age. Age, dental history and medical history were recorded using a questionnaire administered to the children's parents/caregivers. Previously trained and calibrated examiners assessed radiographic images of the primary molars by direct observation, with the aid of a viewing box. Root resorption (physiological or inflammatory)...

Raquel Gonçalves Vieira-Andrade; Clarissa Lopes Drumond; Laura Pereira Azevedo Alves; Leandro Silva Marques; Maria Letícia Ramos-Jorge

2012-01-01

97

Inflammatory root resorption in primary molars: prevalence and associated factors  

Directory of Open Access Journals (Sweden)

Full Text Available This study aimed at determining the prevalence of inflammatory root resorption and associated factors in 1068 primary mandibular molars in 453 children 3 to 12 years of age. Age, dental history and medical history were recorded using a questionnaire administered to the children's parents/caregivers. Previously trained and calibrated examiners assessed radiographic images of the primary molars by direct observation, with the aid of a viewing box. Root resorption (physiological or inflammatory, dental crown status (healthy, carious with no pulp involvement, carious with pulp involvement and evidence of restoration, and pulpotomy or pulpectomy were determined. Data analysis involved descriptive statistics, the chi-square test and a multiple logistic regression (p < 0.05. The prevalence of inflammatory root resorption was 16.2% (n = 173. The male gender (OR: 1.4; 95% CI, the 3-to-7-years age bracket (OR: 1.5; 95% CI, an unhealthy dental crown (OR: 8.7; 95% CI, caries with pulp involvement (OR: 7.4; 95% CI, pulpotomy (OR: 3.1; 95% CI, and pulpectomy (OR: 5.4; 95% CI were risk factors for the occurrence of inflammatory root resorption in primary molars. In conclusion, the prevalence of inflammatory root resorption in the present sample was 16.2%. Gender, age, an unhealthy tooth, caries with pulp involvement, pulpotomy, pulpectomy, and the absence of a restoration were associated with a higher occurrence of inflammatory root resorption in primary molars.

Raquel Gonçalves Vieira-Andrade

2012-08-01

98

True Fibroma of Alveolar Mucosa  

OpenAIRE

Benign fibrous overgrowths are often found in the oral cavity, almost always being reactive/irritational in nature. However, benign mesenchymal neoplasms of the fibroblasts are extremely uncommon. Here we report a case of “True Fibroma of Alveolar Mucosa” for its rarity.

Shankargouda Patil; Rao, Roopa S.; Sanketh Sharath; Anveeta Agarwal

2014-01-01

99

Ridge augmentation with soft tissue procedures in aesthetic dentistry: pre- and postoperative volume measurements with a new kind of moire technique  

Science.gov (United States)

The aim of this paper was to measure the volume differences of operated alveolar ridge defects before and until 3 months post-surgically. Ten patients with ten localized alveolar ridge defects were operated on. Five alveolar ridge defects were corrected by using the full thickness onlay graft technique and the other five defects were operated by the subepithelial connective tissue graft technique. A strict standardized operation protocol was followed and all alveolar ridge defects were operated on by the same dental surgeon. Before as well as 1, 2, and 3 months after surgery the corrected defect was photographed and an impression was made by using an A-silicon material to produce a gypsum-cast model. The form of all these cast models was then measured using the moire technique. The three months result of ten cases shows that the form of the operated alveolar ridge defects, which were corrected by the subepithelial connective tissue graft technique are more stable compared to those which were operated on by the full thickness onlay graft technique. Localized alveolar ridge defects using the latter method does not show a form stability after 3 months post-surgically.

Studer, Stephan P.; Mueller, Ernst; Bucher, Alfred

1993-09-01

100

Distracción osteogénica alveolar por medio de dispositivos yuxtaoseos: Revisión de literatura y reporte de caso  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in portuguese Resumo: A reconstrução dos rebordos alveolares atroficos por meio da técnica de distração osteogênica alveolar (DOA) oferece um resultado previsível com baixas taxas de morbilidade e uma ganância notável de tecido ósseo e tecidos moles, em comparação com as técnicas tradicionalmente utilizadas. Foi [...] atendido um paciente masculino de 21 anos de idade o qual apressentaba afrofia severa do rebordo alveolar na região anterior da maxila por meio de DOA, utilizando um dispositivo yuxtaoseo (Conexão Implant System® - SP-Brasil), começando a ativação do aparelho aos 7 dias após a instalação, com uma padronização de 1mm diários ate lograr os comprimentos ósseos desejado, retirando-se o distrator e colocando-se os implantes osseointegrados às 10 semanas posteriores. Pudo-se comprovar clinica e radiográficamente o incremento em comprimento e volume ósseo necessário para a reabilitação com implantes Abstract in spanish La reconstrucción de rebordes alveolares atróficos por medio de la técnica de distracción osteogénica alveolar (DOA) ofrece un resultado previsible con bajas tasas de morbilidad y una ganancia notable de tejido óseo y tejidos blandos, en comparación con las técnicas tradicionalmente utilizadas. Fue [...] atendido un paciente masculino de 21 años de edad quien presentaba atrofia severa del reborde alveolar en región anterior del maxilar por medio de DOA, utilizando un dispositivo yuxtaoseo (Conexão Implant System® - SP-Brasil). Comenzando la activación del dispositivo a los 7 días posteriores a la instalación, con un patrón de activación de 1 mm. diarios hasta alcanzar la altura ósea deseada, retirándose el distractor y colocando los implantes oseointegrados a las 10 semanas posteriores, pudo comprobarse clínica y radiográficamente el incremento en altura y volumen óseo necesario para la rehabilitación por medio de implantes Abstract in english Abstract: The reconstruction of atrophic alveolar ridges by means of the technique of alveolar distraction osteogenesis (ADO) offers a foregone result with small morbidity rates and a remarkable gain of bony and soft tissues, in comparison with the traditionally used techniques. A masculine patient [...] of 21 years old who presented a severe atrophy of alveolar ridge in the region anterior of the maxillary was assisted by means of ADO, using a juxtaosseous device (Connection Implant System® - SP-Brazil), beginning the activation from the device to the 7 days later to the installation, with a pattern of activation 1 mm. per day until reaching the wanted bony height, being carried out the retirement of the distractor and the placement of the implants 10 weeks later. It could be proven clinic and radiographic the gain of the height and necessary bony volume for the rehabilitation by implants

Paul E, Maurette; Marvis Allais, de Maurette; Renato, Mazzonetto, Msc, PhD.

101

[Differential diagnosis of resorptive tooth diseases and caries].  

Science.gov (United States)

Feline Odontoclastic Resorptive Lesions (FORL, previously known as "neck lesions") on cat teeth are compared to caries and differentiated with the use of new methods. Radiological examination reveals typical odontoclastic resorptive processes, which take place at the dental root and at the periodontium. These lesions demonstrate the destruction on the desmodontium and the following ankylosing reaction. The rhodamine B stain which is selective for caries, stains regions which are softened by caries in a dark red way. Fuchsin/Acetic-Light Green stained histological preparations demonstrate the resorptive lacunae, resorptive lagoons and resorptive canals. Giant cells with multiple nuclei and reparative cementum can also be shown with the same stain. Hardness measurements using a Knoop diamond (KHN Knoop hardness number) give information about the degree of hardness of the different tissues. Electron microscopic investigations are performed to show the dentinal tubules and allowing the differentiation between FORL and caries. Since FORL also has been found in wild cats we deduced that alimentation has no effect on the pathogenesis of the disease. PMID:9026912

Berger, M; Schawalder, P; Stich, H; Lussi, A

1996-01-01

102

Osteoclast-independent bone resorption by fibroblast-like cells  

Science.gov (United States)

To date, mesenchymal cells have only been associated with bone resorption indirectly, and it has been hypothesized that the degradation of bone is associated exclusively with specific functions of osteoclasts. Here we show, in aseptic prosthesis loosening, that aggressive fibroblasts at the bone surface actively contribute to bone resorption and that this is independent of osteoclasts. In two separate models (a severe combined immunodeficient mouse coimplantation model and a dentin pit formation assay), these cells produce signs of bone resorption that are similar to those in early osteoclastic resorption. In an animal model of aseptic prosthesis loosening (i.e. intracranially self-stimulated rats), it is shown that these fibroblasts acquire their ability to degrade bone early on in their differentiation. Upon stimulation, such fibroblasts readily release acidic components that lower the pH of their pericellular milieu. Through the use of specific inhibitors, pericellular acidification is shown to involve the action of vacuolar type ATPases. Although fibroblasts, as mesenchymal derived cells, are thought to be incapable of resorbing bone, the present study provides the first evidence to challenge this widely held belief. It is demonstrated that fibroblast-like cells, under pathological conditions, may not only enhance but also actively contribute to bone resorption. These cells should therefore be considered novel therapeutic targets in the treatment of bone destructive disorders. PMID:12723988

Pap, Thomas; Claus, Anja; Ohtsu, Susumu; Hummel, Klaus M; Schwartz, Peter; Drynda, Susanne; Pap, Géza; Machner, Andreas; Stein, Bernhard; George, Michael; Gay, Renate E; Neumann, Wolfram; Gay, Steffen; Aicher, Wilhelm K

2003-01-01

103

Effects of a Mikania laevigata extract on bone resorption and RANKL expression during experimental periodontitis in rats  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english OBJECTIVES: The Mikania laevigata extract (MLE) (popularly known in Brazil as "guaco") possesses anti-inflammatory properties. In the present study we tested the effects of MLE in a periodontitis experimental model in rats. We also investigated possible mechanisms underlying such effects. MATERIAL A [...] ND METHODS: Periodontal disease was induced by a ligature placed around the mandibular first molars of each animal. Male Wistar rats were divided into 4 groups: non-ligated animals treated with vehicle; non-ligated animals treated with MLE (10 mg/kg, daily); ligature-induced animals treated with vehicle and ligature-induced animals treated with MLE (10 mg/kg, daily). Thirty days after the induction of periodontal disease, the animals were euthanized and mandibles and gingival tissues removed for further analysis. RESULTS: Morphometric analysis of alveolar bone loss demonstrated that MLE-treated animals presented a decreased alveolar bone loss and a lower expression of the activator of nuclear factor-?B ligand (RANKL) measured by immunohistochemistry. Moreover, gingival tissues from the MLE-treated group showed decreased neutrophil migration myeloperoxidase (MPO) assay. CONCLUSIONS: These results indicate that MLE may be useful to control bone resorption during progression of experimental periodontitis in rats.

Bruno B., Benatti; Jozafá C., Campos-Júnior; Vilmar J., Silva-Filho; Polyanna M., Alves; Isabela R., Rodrigues; Elizabeth, Uber-Bucek; Silvio M., Vieira; Marcelo H., Napimoga.

2012-06-01

104

Rac-null leukocytes are associated with increased inflammation-mediated alveolar bone loss.  

Science.gov (United States)

Periodontitis is characterized by altered host-biofilm interactions that result in irreversible inflammation-mediated alveolar bone loss. Genetic and epigenetic factors that predispose to ineffective control of biofilm composition and maintenance of tissue homeostasis are not fully understood. We elucidated how leukocytes affect the course of periodontitis in Rac-null mice. Mouse models of acute gingivitis and periodontitis were used to assess the early inflammatory response and patterns of chronicity leading to loss of alveolar bone due to inflammation in Rac-null mice. Leukocyte margination was differentially impaired in these mice during attachment in conditional Rac1-null (granulocyte/monocyte lineage) mice and during rolling and attachment in Rac2-null (all blood cells) mice. Inflammatory responses to subgingival ligatures, assessed by changes in peripheral blood differential leukocyte numbers, were altered in Rac-null compared with wild-type mice. In response to persistent subgingival ligature-mediated challenge, Rac-null mice had increased loss of alveolar bone with patterns of resorption characteristic of aggressive forms of periodontitis. These findings were partially explained by higher osteoclastic coverage of the bone-periodontal ligament interface in Rac-null compared with wild-type mice. In conclusion, this study demonstrates that leukocyte defects, such as decreased endothelial margination and tissue recruitment, are rate-limiting steps in the periodontal inflammatory process that lead to more aggressive forms of periodontitis. PMID:24269593

Sima, Corneliu; Gastfreund, Shoshi; Sun, Chunxiang; Glogauer, Michael

2014-02-01

105

B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection  

Directory of Open Access Journals (Sweden)

Full Text Available Periodontal disease is one of the most common infectious diseases of humans. Immune responses to infection trigger loss of alveolar bone from the jaw and eventual tooth loss. We investigated the contribution of B cell IgD to alveolar bone loss by comparing the response of B cell normal BALB/cJ mice and IgD deficient BALB/c-Igh-5?/?J mice to oral infection with Porphyromonas gingivalis, a gram-negative periodontopathic bacterium from humans. P. gingivalis-infected normal mice lost bone. Specific antibody to P. gingivalis was lower and oral colonization was higher in IgD deficient mice; yet bone loss was completely absent. Infection increased the proportion of CD69+ activated B cells and CD4+ T cells in immune normal mice compared to IgD deficient mice. These data suggest that IgD is an important mediator of alveolar bone resorption, possibly through antigen-specific coactivation of B cells and CD4+ T cells.

Pamela J. Baker

2009-01-01

106

NOD2 contributes to Porphyromonas gingivalis-induced bone resorption.  

Science.gov (United States)

The NOD-like receptors are cytoplasmic proteins that sense microbial by-products released by invasive bacteria. Although NOD1 and NOD2 are functionally expressed in cells from oral tissues and play a role triggering immune responses, the role of NOD2 receptor in the bone resorption and in the modulation of osteoclastogenesis is still unclear. We show that in an experimental model of periodontitis with Porphyromonas gingivalis W83, NOD2(-/-) mice showed lower bone resorption when compared to wild type. Quantitative polymerase chain reaction analysis revealed that wild-type infected mice showed an elevated RANKL/OPG ratio when compared to NOD2(-/-) infected mice. Moreover, the expression of 2 osteoclast activity markers-cathepsin K and matrix metalloproteinase 9-was significantly lower in gingival tissue from NOD2(-/-) infected mice compared to WT infected ones. The in vitro study reported an increase in the expression of the NOD2 receptor 24 hr after stimulation of hematopoietic bone marrow cells with M-CSF and RANKL. We also evaluated the effect of direct activation of NOD2 receptor on osteoclastogenesis, by the activation of this receptor in preosteoclasts culture, with different concentrations of muramyl dipeptide. The results show no difference in the number of TRAP-positive cells. Although it did not alter the osteoclasts differentiation, the activation of NOD2 receptor led to a significant increase of cathepsin K expression. We confirm that this enzyme was active, since the osteoclasts resorption capacity was enhanced by muramyl dipeptide stimulation, evaluated in osteoassay plate. These results show that the lack of NOD2 receptor impairs the bone resorption, suggesting that NOD2 receptor could contribute to the progression of bone resorption in experimental model of periodontitis. The stimulation of NOD2 by its agonist, muramyl dipeptide, did not affect osteoclastogenesis, but it does favor the bone resorption capacity identified by increased osteoclast activity. PMID:25239844

Prates, T P; Taira, T M; Holanda, M C; Bignardi, L A; Salvador, S L; Zamboni, D S; Cunha, F Q; Fukada, S Y

2014-11-01

107

Humoral Regulation of Osteoclasts and Their Role in Bone Resorption  

Directory of Open Access Journals (Sweden)

Full Text Available Osteoclasts are derived from the macrophage haematopoietic lineage, resemble monocyte-like phagocytic cells, and are involved in bone resorption. The cells of the bone and the immune system communicate by cytokines and growth factors. The discovery of the receptor activator of nuclear factor kappa B (RANK signalling pathway in osteoclasts provides a deeper understanding of osteoclastogenesis, mechanisms of the activation of bone resorption, and how bone structure and mass are affected by hormones. Turk Jem 2008; 12: 12-7

Hatice Sebile Dökmeta?

2008-05-01

108

Rhizoma Dioscoreae Extract Protects against Alveolar Bone Loss in Ovariectomized Rats via microRNAs Regulation  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this study was to evaluate the osteoprotective effect of aqueous Rhizoma Dioscoreae extract (RDE on the alveolar bone of rats with ovariectomy-induced bone loss. Female Wistar rats underwent either ovariectomy or sham operation (SHAM. The ovariectomized (OVX rats were treated with vehicle (OVX, estradiol valerate (EV, or RDE. After treatments, the bone mineral density (BMD and the three-dimensional microarchitecture of the alveolar bone were analyzed to assess bone mass. Microarrays were used to evaluate microRNA expression profiles in alveolar bone from RDE-treated and OVX rats. The differential expression of microRNAs was validated using real-time quantitative RT-PCR (qRT-PCR, and the target genes of validated microRNAs were predicted and further analyzed using Ingenuity Pathway Analysis (IPA. The key findings were verified using qRT-PCR. Our results show that RDE inhibits alveolar bone loss in OVX rats. Compared to the OVX rats, the RDE-treated rats showed upregulated expression levels of 8 microRNAs and downregulated expression levels of 8 microRNAs in the alveolar bone in the microarray analysis. qRT-PCR helped validate 13 of 16 differentially expressed microRNAs, and 114 putative target genes of the validated microRNAs were retrieved. The IPA showed that these putative target genes had the potential to code for proteins that were involved in the transforming growth factor (TGF-?/bone morphogenetic proteins (BMPs/Smad signaling pathway (Tgfbr2/Bmpr2, Smad3/4/5, and Bcl-2 and interleukin (IL-6/oncostatin M (OSM/Jak1/STAT3 signaling pathway (Jak1, STAT3, and Il6r. These experiments revealed that RDE could inhibit ovariectomy-induced alveolar bone loss in rats. The mechanism of this anti-osteopenic effect in alveolar bone may involve the simultaneous inhibition of bone formation and bone resorption, which is associated with modulation of the TGF-?/BMPs/Smad and the IL-6/OSM/Jak1/STAT3 signaling pathways via microRNA regulation.

Zhiguo Zhang

2015-02-01

109

Rhizoma Dioscoreae Extract Protects against Alveolar Bone Loss in Ovariectomized Rats via microRNAs Regulation.  

Science.gov (United States)

The aim of this study was to evaluate the osteoprotective effect of aqueous Rhizoma Dioscoreae extract (RDE) on the alveolar bone of rats with ovariectomy-induced bone loss. Female Wistar rats underwent either ovariectomy or sham operation (SHAM). The ovariectomized (OVX) rats were treated with vehicle (OVX), estradiol valerate (EV), or RDE. After treatments, the bone mineral density (BMD) and the three-dimensional microarchitecture of the alveolar bone were analyzed to assess bone mass. Microarrays were used to evaluate microRNA expression profiles in alveolar bone from RDE-treated and OVX rats. The differential expression of microRNAs was validated using real-time quantitative RT-PCR (qRT-PCR), and the target genes of validated microRNAs were predicted and further analyzed using Ingenuity Pathway Analysis (IPA). The key findings were verified using qRT-PCR. Our results show that RDE inhibits alveolar bone loss in OVX rats. Compared to the OVX rats, the RDE-treated rats showed upregulated expression levels of 8 microRNAs and downregulated expression levels of 8 microRNAs in the alveolar bone in the microarray analysis. qRT-PCR helped validate 13 of 16 differentially expressed microRNAs, and 114 putative target genes of the validated microRNAs were retrieved. The IPA showed that these putative target genes had the potential to code for proteins that were involved in the transforming growth factor (TGF)-?/bone morphogenetic proteins (BMPs)/Smad signaling pathway (Tgfbr2/Bmpr2, Smad3/4/5, and Bcl-2) and interleukin (IL)-6/oncostatin M (OSM)/Jak1/STAT3 signaling pathway (Jak1, STAT3, and Il6r). These experiments revealed that RDE could inhibit ovariectomy-induced alveolar bone loss in rats. The mechanism of this anti-osteopenic effect in alveolar bone may involve the simultaneous inhibition of bone formation and bone resorption, which is associated with modulation of the TGF-?/BMPs/Smad and the IL-6/OSM/Jak1/STAT3 signaling pathways via microRNA regulation. PMID:25690421

Zhang, Zhiguo; Song, Changheng; Zhang, Fangzhen; Xiang, Lihua; Chen, Yanjing; Li, Yan; Pan, Jinghua; Liu, Hong; Xiao, Gary Guishan; Ju, Dahong

2015-01-01

110

Effect of fish oil on lipopolysaccharide-induced hydroxyapatite loss in rat alveolar bone: A Preliminary Study  

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Full Text Available Dietary fish oil has been shown to inhibit bone resorption and, therefore, the aim of the present study was to test the hypothesis that fish oil alters lipopolysaccharide (LPS-induced hydroxyapatite loss in rat alveolar bone. Rats were divided into four groups. The animals injected with saline or Escherichia coli-derived LPS into the maxillary alveolar mucosa on the buccoapical site of the molar region daily for 8 days were served as a negative or positive control, respectively. Other groups of animals were injected with LPS and orally treated with fish oil at the same day with or after LPS injection. The results of the present study showed that the hydroxyapatite contents of alveolar bone in rats treated with fish oil at the same day with or before LPS injection were significantly higher than those in rats injected with LPS alone, but still lower than those in untreated animals. Therefore, the present study suggests that oral treatment with fish oil may reduce LPS-induced hydroxyapatite loss in rat alveolar bone

Didin E. Indahyani

2009-02-01

111

The effect of photobiomodulation on root resorption during orthodontic treatment.  

Science.gov (United States)

Photobiomodulation is used to accelerate tooth movement during orthodontic treatments. The changes in root morphology in a group of orthodontic patients who received photobiomodulation were evaluated using the cone beam computed tomography technique. The device used is called OrthoPulse, which produces low levels of light with a near infrared wavelength of 850 nm and an intensity of 60 mW/cm(2) continuous wave. Twenty orthodontic patients were recruited for these experiments, all with class 1 malocclusion and with Little's Irregularity Index (>2 mm) in either of the arches. Root resorption was detected by measuring changes in tooth length using cone beam computed tomography. These changes were measured before the orthodontic treatment and use of low-level laser therapy and after finishing the alignment level. Little's Irregularity Index for all the patients was calculated in both the maxilla and mandible and patients were divided into three groups for further analysis, which were then compared to the root resorption measurements. Our results showed that photobiomodulation did not cause root resorption greater than the normal range that is commonly detected in orthodontic treatments. Furthermore, no correlation between Little's Irregularity Index and root resorption was detected. PMID:24470774

Nimeri, Ghada; Kau, Chung H; Corona, Rachel; Shelly, Jeffery

2014-01-01

112

Alveolar soft-part sarcoma.  

OpenAIRE

Alveolar soft-part sarcoma is a slow-growing but nevertheless malignant soft tissue tumour arising in muscle. It occurs most frequently in young women and often presents as a painless swelling in an upper or lower limb. The swelling, which may have been present for a considerable time, is firm and appears to be well circumscribed but it may recur locally after excision. Blood-borne metastases to the lung are common and this is frequently the mode of presentation. Lymphatic metastases are unus...

Hurt, R.; Bates, M.; Harrison, W.

1982-01-01

113

Alveolar Gas - Mac 10.7 Version  

Science.gov (United States)

Alveolar Gas is a computer program that lets you study some of the physiological factors that affect the composition of alveolar and expired gases. Such factors include dead space, tidal volume, the frequency of breathing, and the rates of oxygen consumption and carbon dioxide production. A worksheet is included.

2012-09-20

114

Intracranial alveolar echinococcosis: CT and MRI  

Energy Technology Data Exchange (ETDEWEB)

Intracranial alveolar echinococcosis is uncommon. We report a patient with right frontal lobe and palpebral lesions secondary to a primary hepatic focus with secondary lesion in the lung. The intracranial and palpebral cystic masses were totally removed and both proved to be alveolar hydatid cysts. An unusual feature in this case is CT and MRI demonstration of dural and bony extension. (orig.)

Bensaid, A.H. (Dept. of Radiology B, Univ. Hospital, Strasbourg (France)); Dietemann, J.L. (Dept. of Radiology B, Univ. Hospital, Strasbourg (France)); Filippi de la Palavesa, M.M. (Dept. of Radiology B, Univ. Hospital, Strasbourg (France)); Klinkert, A. (Dept. of Radiology B, Univ. Hospital, Strasbourg (France)); Kastler, B. (Dept. of Radiology B, Univ. Hospital, Strasbourg (France)); Gangi, A. (Dept. of Radiology B, Univ. Hospital, Strasbourg (France)); Jacquet, G. (Dept. of Neurosurgery, Univ. Hospital, Besancon (France)); Cattin, F. (Dept. of Radiology, Univ. Hospital, Besancon (France))

1994-05-01

115

Intracranial alveolar echinococcosis: CT and MRI.  

Science.gov (United States)

Intracranial alveolar echinococcosis is uncommon. We report a patient with right frontal lobe and palpebral lesions secondary to a primary hepatic focus with secondary lesion in the lung. The intracranial and palpebral cystic masses were totally removed and both proved to be alveolar hydatid cysts. An unusual feature in this case is CT and MRI demonstration of dural and bony extension. PMID:8065572

Bensaid, A H; Dietemann, J L; de la Palavesa, M M; Klinkert, A; Kastler, B; Gangi, A; Jacquet, G; Cattin, F

1994-05-01

116

Alveolar Gas - iPad App  

Science.gov (United States)

This app is for teaching the factors that affect the composition of Â?Alveolar GasÂ?. A student or instructor can manipulate variables like tidal volume, dead space, and the oxygen consumption rate and see how they affect alveolar PO2 and PCO2. The app is suitable for use either as a classroom demonstration or self-instruction.

2012-08-23

117

Metastatic angiosarcoma presenting as diffuse alveolar hemorrhage  

Directory of Open Access Journals (Sweden)

Full Text Available Angiosarcoma is a rare malignant neoplasm of the vascular or lymphatic endothe-lium. Diffuse alveolar hemorrhage is a rare presenting manifestation of angiosar-coma. We describe a case of pulmonary metastasis of angiosarcoma who presented with diffuse alveolar hemorrhage as initial manifestation.

Rai S

2008-01-01

118

Identification of A Novel Root Resorptive Function of Osteopontin Gene  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Osteopontin (OPN has been proposed to play a role in bone resorption. With regard to bone and cementum/dentin structural and histological similarities, it was hy-pothesized that expression of this gene might be increased in resorptive lacunae during orthodontic tooth movement.Materials and Methods: Fixed Nickel-Titanium closed coil springs (Dentaurum® capa-ble of delivering approximately 60 gf were applied for mesial movement of maxillary left first molars in 26 male 8-week-old Wistar rats. The right maxillary molar served as inter-nal control for each subject. After 21 days, the rats were sacrificed. Tissues from 13 rats were examined by histomorphometric analysis and the scratched material from resorptive lacunae on mesial sides of the roots was used for extracting messenger ribonucleic acid (mRNA in RT-PCR reactions. T-test and Wilcoxon signed-rank test served for statistical analyses.Results: Histomorphometric analysis of histologic sections revealed an increased resorbed area in test group compared to control animals (P<0.001. The integrity of mRNA con-firmed by RT-PCR for housekeeping gene glyceraldehyde 3-phosphate dehydrogenase (GAPDH. Densitometric analysis of OPN mRNA on electrophoresis gel showed an in-crease in background levels of OPN in resorptive lacunae of test group (P<0.001.Conclusion: Data indicates that in the controlled environment of this study, an increase in OPN expression is associated with root resorption induced by orthodontic tooth move-ment.

M. Seifi

2008-12-01

119

Evaluation of intracerebral hematoma resorption dynamics with computed tomography  

International Nuclear Information System (INIS)

High mortality and severe grade of disability observed in patients after intracerebral hemorrhage provide efforts to improve diagnostics and therapy of the hemorrhagic cerebral stroke. An aim of this paper was an evaluation of blood resorption dynamics in patients with intracerebral hematoma, performed with computed tomography of the head and an analysis of clinical significance of this process. An examined group included 133 patients with intracerebral hematoma proven by a CT exam. In 97 patients resorption of the hematoma was measured, based on control scans taken on 15th and 30th day on average. Volume of the hemorrhagic foci was measured as well as the width of ventricles and the displacement of medial structures. The mean hematoma volume reached 11,59 ml after 15 days, and 3,16 m after 30 days (average decrease of the volume 0,67 ml/day). There was a significant difference in the rate of resorption between the first (0-15 days) and the second (15-30 days) observation period - 0,78 and 0,62 ml/day respectively. The dynamics of the process was dependent on volume and localization of the hematoma and independent of the grade of displacement and compression of the ventricles. The calculated mean rate of the hematomas resorption enables to schedule control examinations precisely. The significant differences of the dynamics of blood resorption depending on hematomas size and the independence of compression and displacement of ventricular system su and displacement of ventricular system suggest, that the most important factor in therapeutic decision-making should be a clinical status of the patient. (author)

120

Glucose-dependent insulinotropic polypeptide inhibits bone resorption in humans  

DEFF Research Database (Denmark)

BACKGROUND: In humans, the pronounced postprandial reduction in bone resorption (decreasing bone resorption markers by around 50%) has been suggested to be caused by gut hormones. Glucose-dependent insulinotropic polypeptide (GIP) is a peptide hormone secreted postprandially from the small intestine. The hormone is known as an incretin hormone, but preclinical studies have suggested that it may also influence bone metabolism, showing both antiresorptive and anabolic effects as reflected by changes in biomechanical measures, microarchitecture, and activity of the bone cells in response to GIP stimulation. Its role in human bone homeostasis, however, is unknown. OBJECTIVE: To examine the effect of GIP administration on bone resorption in humans. MATERIALS AND METHODS: Plasma samples were obtained from 10 healthy subjects during four conditions: euglycemic (5 mmol/L) and hyperglycemic (12 mmol/L) 90-minute glucose clamps with co-infusion of GIP (4 pmol/kg/min for 15 min, followed by 2 pmol/kg/min for 45 min) or placebo. The samples were analyzed for concentrations of degradation products of C-terminal telopeptide of type I collagen (CTX), a bone resorption marker. RESULTS regarding effects on pancreatic hormone secretion have been published. RESULTS: During euglycemia, the decremental area under the curve in CTX was significantly (P < .001) higher during GIP infusion (2084 ± 686 % × min) compared to saline infusion (656 ± 295 % × min). During hyperglycemia, GIP infusion significantly (P < .001) augmented the decremental area under the curve to 2785 ± 446 % × minutes, compared to 1308 ± 448 % × minutes during saline infusion, with CTX values corresponding to 49% of basal values. CONCLUSIONS: We conclude that GIP reduces bone resorption in humans, interacting with a possible effect of hyperglycemia.

Nissen, Anne; Christensen, Mikkel

2014-01-01

121

CT features of lung alveolar echinococcosis  

International Nuclear Information System (INIS)

Objective: To analyze the CT features of lung alveolar echinococcosis and assess the value of CT scanning for the diagnosis of this disease. Methods: The CT features of lung alveolar echinococcosis in 26 patients diagnosed pathologically or clinically were reviewed retrospectively and correlated with histopathology. Results: Lung alveolar echinococcosis appeared as multiple lesions bilaterally in 18 patients, as multiple lesions unilaterally in 6 patients, and as single lesion bilaterally in 2 patients. Seventeen cases presented as masses and nodules, 8 patients presented as nodules, 1 patient presented as a mass. Lobulation and speculation were showed in most lesions, irregular cavity or bubble-like opacity in 13 patients,calcification in 18 patients, a patchy area or fibrotic cord around lesion in 14 patients. Pleural thickening adjacent to the lesion in 20 patients. Conclusion: Lung alveolar echinococcosis has characteristic features on CT, and CT can provide important information for the diagnosis of lung alveolar echinococcosis. (authors)

122

Seasonal Variation of Nutrient Resorption in Nine Canopy Trees of a Wet Tropical Forest  

Science.gov (United States)

Withdrawal of nutrients at the time of leaf abscission (nutrient resorption) is a nutrient conserving mechanism that could play an important role in stand-level nutrient economy. Currently data on nutrient resorption in wet tropical forests and on how this process varies temporally are sparse. We evaluated the N and P resorption efficiency of nine rain forest canopy tree species in both wet and dry season months. In addition, we measured short-term (bi-weekly) variation in nutrient resorption in the two dominant tree species, Pentaclethra macroloba and Laetia procera, over a 4-month period. We hypothesized that nutrient resorption would be more efficient during the dry season months and that resorption would be low during periods of high rainfall. Contrary to expectations, P resorption efficiency was higher in the wet season for four of the nine canopy tree species, while N resorption did not differ seasonally. The low dry season P resorption efficiency found in this study may be the result of drought stress during short periods of low rainfall, leading to incomplete nutrient resorption from senescing leaves. Nutrient resorption also varied significantly over the short-term. Both P and N resorption efficiency increased in P. macroloba and L. procera as the wet season progressed. The variability in resorption was not related to rainfall or temperature. Instead, the senesced leaf concentrations were a simple proportion of green leaf nutrient concentrations, with short punctuated periods of high resorption efficiency that may be reflective of species-specific phenological events, such as fruit and leaf production. The different timing of the seasonal increase in nutrient resorption between L. procera and P. macroloba supports this hypothesis, deserving of further study.

Wood, T. E.; Lawrence, D.

2006-12-01

123

Evaluation of the posterior superior alveolar artery and the maxillary sinus with CBCT  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Assessment of the maxillary sinus anatomy before sinus augmentation is important for avoiding surgical complications, because of the close anatomical relationship between the posterior maxillary teeth and the maxillary sinus. The posterior superior alveolar artery (PSAA) is the branch of the maxilla [...] ry artery that supplies the lateral sinus wall and overlying membrane. We evaluated the location of the PSAA and its relationship to the alveolar ridge and maxillary sinus using cone beam computed tomography (CBCT). The study group consisted of 135 CBCT scans (270 sinuses) obtained from the archive of the dentomaxillofacial radiology department at Yeditepe University Faculty of Dentistry, Istanbul, Turkey. The distance between the lower border of the artery and the alveolar crest, bone height from the sinus floor to the ridge crest, distance from the artery to the medial sinus wall, and the diameter and location of the artery were determined. The occurrence of septa and pathology were recorded from CBCT scans. The PSAA was observed in 89.3% of sinuses, and 71.1% of arteries were intraosseous with diameters mostly

Dilhan, Ilguy; Mehmet, Ilguy; Semanur, Dolekoglu; Erdogan, Fisekcioglu.

2013-09-01

124

Fluoride effect on the process of alveolar bone repair in rats: evaluation of activity of MMP-2 and 9  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: The aim of this study was to evaluate comparatively the effect of fluoride (F on the activity of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9 involved in process of alveolar bone repair. Material and methods: This study used 4 groups of Wistar rats with 80 days of life (n = 160 which received drinking water containing different doses of fluoride (NaF: 5, 15, 50 ppm and deionized water (control throughout the experiment. These animals had their right upper incisors extracted. After extraction, the animals were euthanized at 7, 14, 21 and 30 days and the hemi-maxillae were collected for microscopic analysis (Hematoxylin and Eosin and immunohistochemistry for MMP-9 and zymography (MMP-2 and 9. Results: Microscopically the process of bone repair was similar in all groups, being noted only a delay of the blood clot resorption and bone formation in the group of 50 ppm F. The expression for MMP-9 showed differences between groups only during the initial repair (7 days. However, the zymography showed no significant differences between treated and control groups. Conclusion: Ours results suggest an effect of fluoride on the activity of MMPs 2 and 9 at the initial period of alveolar repair which could be associated to the process of blood clot remission and delay in bone repair. Further studies are needed to establish the relationship between the initial process of resorption of the blood clot, and the involvement of MMPs 2 and 9 and its regulators/tissue inhibitors.

Mileni da Silva Fernandes

2012-09-01

125

Porphyromonas gingivalis GroEL Induces Osteoclastogenesis of Periodontal Ligament Cells and Enhances Alveolar Bone Resorption in Rats  

OpenAIRE

Porphyromonas gingivalis is a major periodontal pathogen that contains a variety of virulence factors. The antibody titer to P. gingivalis GroEL, a homologue of HSP60, is significantly higher in periodontitis patients than in healthy control subjects, suggesting that P. gingivalis GroEL is a potential stimulator of periodontal disease. However, the specific role of GroEL in periodontal disease remains unclear. Here, we investigated the effect of P. gingivalis GroEL on human periodontal ligame...

Lin, Feng-yen; Hsiao, Fung-ping; Huang, Chun-yao; Shih, Chun-ming; Tsao, Nai-wen; Tsai, Chien-sung; Yang, Shue-fen; Chang, Nen-chung; Hung, Shan-ling; Lin, Yi-wen

2014-01-01

126

Multiple idiopathic external and internal resorption: Case report with cone-beam computed tomography findings  

Energy Technology Data Exchange (ETDEWEB)

Root resorption is loss of dental hard tissue as a result of clastic activities. The dental hard tissue of permanent teeth does not normally undergo resorption, except in cases of inflammation or trauma. However, there are rare cases of tooth resorption of an unknown cause, known as 'idiopathic root resorption.' This report would discuss a rare case of multiple idiopathic resorption in the permanent maxillary and mandibular teeth of an otherwise healthy 36-year-old male patient. In addition to a clinical examination, the patient was imaged using conventional radiography and cone-beam computed tomography (CBCT). The examinations revealed multiple external and internal resorption of the teeth in all four quadrants of the jaws with an unknown cause. Multiple root resorption is a rare clinical phenomenon that should be examined using different radiographic modalities. Cross-sectional CBCT is useful in the diagnosis and examination of such lesions.

Celikten, Berkan; Uzuntas, Ceren Feriha; Kurt, Hakan [Faculty of Dentistry, Ankara University, Ankara (Turkmenistan)

2014-12-15

127

Multiple idiopathic external and internal resorption: Case report with cone-beam computed tomography findings  

International Nuclear Information System (INIS)

Root resorption is loss of dental hard tissue as a result of clastic activities. The dental hard tissue of permanent teeth does not normally undergo resorption, except in cases of inflammation or trauma. However, there are rare cases of tooth resorption of an unknown cause, known as 'idiopathic root resorption.' This report would discuss a rare case of multiple idiopathic resorption in the permanent maxillary and mandibular teeth of an otherwise healthy 36-year-old male patient. In addition to a clinical examination, the patient was imaged using conventional radiography and cone-beam computed tomography (CBCT). The examinations revealed multiple external and internal resorption of the teeth in all four quadrants of the jaws with an unknown cause. Multiple root resorption is a rare clinical phenomenon that should be examined using different radiographic modalities. Cross-sectional CBCT is useful in the diagnosis and examination of such lesions.

128

Multiple idiopathic external and internal resorption: Case report with cone-beam computed tomography findings.  

Science.gov (United States)

Root resorption is loss of dental hard tissue as a result of clastic activities. The dental hard tissue of permanent teeth does not normally undergo resorption, except in cases of inflammation or trauma. However, there are rare cases of tooth resorption of an unknown cause, known as "idiopathic root resorption." This report would discuss a rare case of multiple idiopathic resorption in the permanent maxillary and mandibular teeth of an otherwise healthy 36-year-old male patient. In addition to a clinical examination, the patient was imaged using conventional radiography and cone-beam computed tomography (CBCT). The examinations revealed multiple external and internal resorption of the teeth in all four quadrants of the jaws with an unknown cause. Multiple root resorption is a rare clinical phenomenon that should be examined using different radiographic modalities. Cross-sectional CBCT is useful in the diagnosis and examination of such lesions. PMID:25473640

Celikten, Berkan; Uzuntas, Ceren Feriha; Kurt, Hakan

2014-12-01

129

Analysis of the prevalence of different topographical characteristics of the residual ridge in mandibular free-end arches Análise da prevalência de diferentes características topográficas do rebordo residual em arcos mandibulares com extremidades livres  

OpenAIRE

This study observed the prevalence of different types of residual ridge inclination in free-ends of mandibles and reported possible correlative factors that may affect resorption. For this purpose, periapical radiographs and individual data collected from a sample of 64 hemiarches were used. Two radiographs were taken of each free-end, and tracing was employed to determine the angles formed by the resorption configuration in the area of the 1st mandibular molar. The following conclusions were...

Carlos Gramani Guedes; Artêmio Luiz Zanetti; Pedro Paulo Feltrin

2004-01-01

130

Update on the etiology of tooth resorption in domestic cats.  

Science.gov (United States)

Based on recent findings of increased vitamin D activity in cats with feline odontoclastic resorptive lesions (FORL), the present article provides further clues on the possible etiology of FORL. Microscopic features of FORL and other peculiarities of feline permanent teeth are compared with pathologic findings obtained from experimental studies in other species. Administration of excess vitamin D or vitamin D metabolites in laboratory animals caused changes to dental and periodontal tissues that resemble histopathologic features of teeth from cats with FORL. Chronic excess dietary vitamin D may be the long-sought cause of multiple tooth resorption in domestic cats. It may also provide a basis for future research on idiopathic hypercalcemia and renal disease in the same species. PMID:15979519

Reiter, Alexander M; Lewis, John R; Okuda, Ayako

2005-07-01

131

Pre-eruptive intracoronal resorption of a permanent first molar.  

Science.gov (United States)

For the last 70 years, the phenomenon of pre-eruptive intracoronal resorption (PIR) has been described in the literature, including a number of case reports illustrating the challenges clinicians face in diagnosing and managing these resorptive defects. Pre-eruptively affected teeth can be difficult to access and posteruptively they are difficult to diagnose because the defects resemble caries. Many times, these defects are not detected until after eruption, when the majority are diagnosed as dental decay and teeth are often subjected to surgical tooth restoration. The purposes of this paper are to report a case of nonprogressive PIR that was detected early, treated with a preventive glass ionomer sealant, and monitored for 44 months, and to propose an alternative approach to management of nonprogressive defects that may help preserve tooth structure. PMID:25514260

Czarnecki, Gail; Morrow, Melissa; Peters, Mathilde; Hu, Jan

2015-01-01

132

Experimental study of diamond resorption during mantle metasomatism  

Science.gov (United States)

Many of kimberlite-derived diamonds are partially dissolved to various degree but show similar resorption style. This resorption style has been observed in experiments with aqueous fluid at the conditions corresponding to kimberlite emplacement (1-2 GPa). At the same time, each diamond population has more than ten percent of diamond crystals with several drastically different resorption styles, which have not been observed in experiments, and may represent partial dissolution of diamonds during metasomatism in different mantle domains. Metasomatic processes modify the composition of subcratonic mantle, may trigger the formation of kimberlite magma, and result in the growth and partial dissolution of diamonds. Composition of metasomatic agents as constrained from studies of the reaction rims on mantle minerals (garnet, clinopyroxene) and experimental studies vary between carbonatitic melt, aqueous silicate melt, and CHO fluid. However, complex chemical pattern of mantle minerals and estimates of redox regime in subcratonic mantle allow different interpretations. Here we explore diamond dissolution morphology as an indicator of the composition of mantle metasomatic agents. Towards this end we examine diamond dissolution morphologies developed in experiments at the conditions of mantle metasomatism in different reacting media and compare them to the mantle-derived dissolution features of natural diamonds. The experiments were conducted in multi-anvil (Walker-Type) apparatus at 6 GPa and 1200-1500oC. Dissolution morphology of natural octahedral diamond crystals (0.5 mg) was examined in various compositions in synthetic system MgO-CaO- SiO2-CO2-H2O. The runs had the following phases present: solid crystals with fluid (various ratio of H2O-CO2-SiO2, and in the air), carbonate melt, carbonate-silicate melt, and carbonate melt with CHO fluid. Experiments produced three different styles of diamond resorption. In the presence of a fluid phase with variable proportions of H2O and CO2 diamond crystals develop ditrigonal outline of {111} faces, striation or hillocks along the edges, and shallow negatively oriented trigonal etch pits with flat or pointed bottom. Presence of SiO2 in the fluid resulted in multi-corner morphology, layering and / or more intensive etching of {111} faces. Dissolution in carbonate melt in the absence of water produced deep stepped-wall hexagonal and trigonal etch pits with negative orientation. The three resorption styles show strong resemblance to the secondary morphology of natural diamonds. This suggests that CHO fluid, aqueous silicate melt, and carbonatatitic melt are metasomatic agents reacting with natural diamonds in subcratonic mantle. The comparison of the experimentally-induced resorption styles to those on natural diamonds show that mantle metasomatism induced by CHO fluid develop morphologies similar to those developed in kimberlite magma. This indicates that significant proportion of kimberlite-hosted diamonds may show resorption features of mantle origin. Aqueous silicate melt induces step-faced multi-corner resorption morphology, similar to natural diamonds with nitrogen aggregation corresponding to eclogitic diamonds. Dissolution in carbonatitic melt results in complex morphologies with deep hexagonal pits similar to natural diamonds with nitrogen data corresponding to peridotitic diamonds.

Fedorchuk, Yana; Schmidt, Max W.; Liebske, Christian

2014-05-01

133

Inflammatory root resorption in primary molars: prevalence and associated factors  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english This study aimed at determining the prevalence of inflammatory root resorption and associated factors in 1068 primary mandibular molars in 453 children 3 to 12 years of age. Age, dental history and medical history were recorded using a questionnaire administered to the children's parents/caregivers. [...] Previously trained and calibrated examiners assessed radiographic images of the primary molars by direct observation, with the aid of a viewing box. Root resorption (physiological or inflammatory), dental crown status (healthy, carious with no pulp involvement, carious with pulp involvement and evidence of restoration), and pulpotomy or pulpectomy were determined. Data analysis involved descriptive statistics, the chi-square test and a multiple logistic regression (p

Raquel Gonçalves, Vieira-Andrade; Clarissa Lopes, Drumond; Laura Pereira Azevedo, Alves; Leandro Silva, Marques; Maria Letícia, Ramos-Jorge.

2012-08-01

134

Alveolar soft-part sarcoma.  

Science.gov (United States)

Alveolar soft-part sarcoma is a slow-growing but nevertheless malignant soft tissue tumour arising in muscle. It occurs most frequently in young women and often presents as a painless swelling in an upper or lower limb. The swelling, which may have been present for a considerable time, is firm and appears to be well circumscribed but it may recur locally after excision. Blood-borne metastases to the lung are common and this is frequently the mode of presentation. Lymphatic metastases are unusual. The tumour is composed of nests of large cells and the histological appearances may resemble those of a renal adenocarcinoma (hypernephroma). Six new cases of this very rare tumour are presented and the published reports are reviewed. Images PMID:6763372

Hurt, R; Bates, M; Harrison, W

1982-01-01

135

Cortical Bone Resorption Following Muscle Paralysis is Spatially Heterogeneous  

OpenAIRE

Mechanical loading of the skeleton, as induced by muscle function during activity, plays a critical role in maintaining bone homeostasis. It is not understood, however, whether diminished loading (and thus diminished mechanical stimuli) directly mediates the bone resorption that is associated with disuse. Our group has recently developed a murine model in which we have observed rapid and profound bone loss in the tibia following transient paralysis of the calf muscles. As cortical bone loss i...

Ausk, Brandon J.; Huber, Philippe; Poliachik, Sandra L.; Bain, Steven D.; Srinivasan, Sundar; Gross, Ted S.

2011-01-01

136

Cellular mechanisms of bone resorption in breast carcinoma  

OpenAIRE

The cellular mechanisms that account for the increase in osteoclast numbers and bone resorption in skeletal breast cancer metastasis are unclear. Osteoclasts are marrow-derived cells which form by fusion of mononuclear phagocyte precursors that circulate in the monocyte fraction. In this study we have determined whether circulating osteoclast precursors are increased in number or have an increased sensitivity to humoral factors for osteoclastogenesis in breast cancer patients with skeletal me...

Hunt, Nc; Fujikawa, Y.; Sabokbar, A.; Itonaga, I.; Harris, A.; Athanasou, Na

2001-01-01

137

Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis  

OpenAIRE

Bone destruction is a frequent and clinically serious event in patients with rheumatoid arthritis (RA). Local joint destruction can cause joint instability and often necessitates reconstructive or replacement surgery. Moreover, inflammation-induced systemic bone loss is associated with an increased fracture risk. Bone resorption is a well-controlled process that is dependent on the differentiation of monocytes to bone-resorbing osteoclasts. Infiltrating as well as resident synovial cells, suc...

Braun, Tobias; Zwerina, Jochen

2011-01-01

138

Mechanisms of subretinal fluid resorption in the cat eye.  

Science.gov (United States)

Small, non-rhegmatogenous retinal detachments (blebs) were made in cat eyes by injecting fluid into the subretinal space, and the time course of fluid resorption was monitored. Blebs made with Hanks' solution over the pigmented RPE resorbed 22% faster than those over the tapetum. Blebs made with a non-ionic solution (isotonic sucrose) took 43% longer to resorb than those made with Hanks' solution, and blebs containing 3 X 10(-3) M sodium cyanide took 32% longer than controls. These results suggest that active ionic transport is involved in the absorption of subretinal fluid in the cat, as it is in the rabbit. Oncotic pressure in the choroid may also contribute to resorption, because blebs made with autologous serum took roughly 3 times longer to resorb than those made with non-proteinaceous Hanks' solution. The retinal vascular system does not appear to contribute, since the resorption time was similar for Hanks' blebs made under normal retina and those made under ischemic retina (produced by occluding retinal branch arteries with argon laser photocoagulation or endodiathermy). PMID:3771135

Negi, A; Marmor, M F

1986-11-01

139

Patterns in foliar nutrient resorption stoichiometry at multiple scales: controlling factors and ecosystem consequences (Invited)  

Science.gov (United States)

During leaf senescence, nutrient rich compounds are transported to other parts of the plant and this 'resorption' recycles nutrients for future growth, reducing losses of potentially limiting nutrients. Variations in leaf chemistry resulting from nutrient resorption also directly affect litter quality, in turn, regulating decomposition rates and soil nutrient availability. Here we investigated stoichiometric patterns of nitrogen (N) and phosphorus (P) resorption efficiency at multiple spatial scales. First, we assembled a global database to explore nutrient resorption among and within biomes and to examine potential relationships between resorption stoichiometry and ecosystem nutrient status. Next, we used a forest regeneration chronosequence in Brazil to assess how resorption stoichiometry linked with a suite of other nutrient cycling measures and with ideas of how nutrient limitation may change over secondary forest regrowth. Finally, we measured N:P resorption ratios of six canopy tree species in a Costa Rican tropical forest. We calculated species-specific resorption ratios and compared them with patterns in leaf litter and topsoil nutrient concentrations. At the global scale, N:P resorption ratios increased with latitude and decreased with mean annual temperature (MAT) and precipitation (MAP; P1 in latitudes >23°. Focusing on tropical sites in our global dataset we found that, despite fewer data and a restricted latitudinal range, a significant relationship between latitude and N:P resorption ratios persisted (Prelationship with MAP was only marginally significant (P=0.089). Data suggest that soil type, at least in part, helps explain N:P resorption patterns across tropical latitudes: plants on more weathered soils (Oxisols and Ultisols) resorbed much more P relative to N and weathered soils were proportionally more abundant at the lowest latitudes. In our assessment of nutrient resorption along an Amazon Basin chronosequence of regenerating forests, where previous work reported a transition from apparent N limitation in younger forests to P limitation in mature forests, we found N resorption was highest in the youngest forest, whereas P resorption was greatest in the mature forest. Over the course of succession, N resorption efficiency leveled off but P resorption continued to increase with forest age. In Costa Rica, though we found species-specific patterns in resorption, data support the idea that lowland tropical forest plants on highly weathered soils resorb more P relative to N. Together, these data highlight how stoichiometric perspectives can help distill the complexity of coupled biogeochemical cycles and suggest that nutrient resorption ratios offer a complementary metric for assessing nutrient limitation in terrestrial ecosystems.

Reed, S.; Cleveland, C. C.; Davidson, E. A.; Townsend, A. R.

2013-12-01

140

Disseminated intracerebral alveolar echinococcosis: CT and MRI  

International Nuclear Information System (INIS)

Cerebral alveolar echinococcosis is rare and has a poor prognosis. We report an unusual case presenting with disseminated intracranial lesions secondary to primary hepatic infection. (orig.). With 3 figs

141

Disseminated intracerebral alveolar echinococcosis: CT and MRI  

Energy Technology Data Exchange (ETDEWEB)

Cerebral alveolar echinococcosis is rare and has a poor prognosis. We report an unusual case presenting with disseminated intracranial lesions secondary to primary hepatic infection. (orig.). With 3 figs.

Piotin, M. [Department of Diagnostic and Interventional Radiology, University Hospital, 24 rue Micheli-du-Crest, CH-1211 Geneva 14 (Switzerland); Cattin, F. [Department of Radiology B, University Hospital, Besancon (France); Kantelip, B. [Department of Pathology, University Hospital, Besancon (France); Miralbes, S. [Department of Radiology B, University Hospital, Besancon (France); Godard, J. [Department of Neurosurgery, University Hospital, Besancon (France); Bonneville, J.F. [Department of Radiology B, University Hospital, Besancon (France)

1997-06-01

142

Compression-absorption (resorption) refrigerating machinery. Modeling of reactors; Machine frigorifique a compression-absorption (resorption). Modelisation des reacteurs  

Energy Technology Data Exchange (ETDEWEB)

This paper is a series of transparencies presenting a comparative study of the thermal performances of different types of refrigerating machineries: di-thermal with vapor compression, tri-thermal with moto-compressor, with ejector, with free piston, adsorption-type, resorption-type, absorption-type, compression-absorption-type. A prototype of ammonia-water compression-absorption heat pump is presented and modeled. (J.S.)

Lottin, O.; Feidt, M.; Benelmir, R. [LEMTA-UHP Nancy-1, 54 - Vandoeuvre-les-Nancy (France)

1997-12-31

143

Responses of plant nutrient resorption to phosphorus addition in freshwater marsh of Northeast China  

Science.gov (United States)

Anthropogenic activities have increased phosphorus (P) inputs to most aquatic and terrestrial ecosystems. However, the relationship between plant nutrient resorption and P availability is still unclear, and much less is known about the underlying mechanisms. Here, we used a multi-level P addition experiment (0, 1.2, 4.8, and 9.6 g P m-2 year-1) to assess the effect of P enrichment on nutrient resorption at plant organ, species, and community levels in a freshwater marsh of Northeast China. The response of nutrient resorption to P addition generally did not vary with addition rates. Moreover, nutrient resorption exhibited similar responses to P addition across the three hierarchical levels. Specifically, P addition decreased nitrogen (N) resorption proficiency, P resorption efficiency and proficiency, but did not impact N resorption efficiency. In addition, P resorption efficiency and proficiency were linearly related to the ratio of inorganic P to organic P and organic P fraction in mature plant organs, respectively. Our findings suggest that the allocation pattern of plant P between inorganic and organic P fractions is an underlying mechanism controlling P resorption processes, and that P enrichment could strongly influence plant-mediated biogeochemical cycles through altered nutrient resorption in the freshwater wetlands of Northeast China.

Mao, Rong; Zeng, De-Hui; Zhang, Xin-Hou; Song, Chang-Chun

2015-01-01

144

A scanning electron microscopic study of the patterns of external root resorption under different conditions  

Scientific Electronic Library Online (English)

Full Text Available OBJECTIVE: The aim of this study was to examine if there are qualitative differences in the appearance of external root resorption patterns of primary teeth undergoing physiologic resorption and permanent teeth undergoing pathological root resorption in different conditions. MATERIAL AND METHODS: A [...] total of 40 teeth undergoing external root resorption in different conditions were divided into 4 groups and prepared for examination under scanning electron microscopy at magnifications ranging from 20x to 1000x. Group I: 10 primary molars exfoliated due to physiologic root resorption; Group II: 10 permanent teeth with periapical granulomas showing signs of resorption; Group III:10 permanent teeth therapeutically extracted during the course of orthodontic therapy with evidence of resorption, and Group IV: 10 permanent teeth associated with odontogenic tumors that showed evidence of resorption. RESULTS: In Group I, the primary teeth undergoing resorption showed smooth extensive and predominantly regular areas reflecting the slow ongoing physiologic process. In Group II, the teeth with periapical granulomas showed the resorption was localized to apex with a funnel shaped appearance in most cases. Teeth in Group III, which had been subjected to a short period of light orthodontic force, showed the presence of numerous resorption craters with adjoining areas of cemental repair in some cases. Teeth associated with odontogenic tumors in Group IV showed many variations in the patterns of resorption with extensive loss of root length and a sharp cut appearance of the root in most cases. CONCLUSION: Differences were observed in the patterns of external root resorption among the studied groups of primary and permanent teeth under physiologic and pathological conditions.

Ravindran, Sreeja; Chaudhary, Minal; Tumsare, Madhuri; Patil, Swati; Wadhwan, Vijay.

2009-10-01

145

The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats / Influência da ovariectomia, da sinvastatina e do alendronato sódico no osso alveolar em ratas  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Os bisfosfonatos são empregados atualmente para o tratamento de várias doenças caracterizadas pelo aumento da reabsorção óssea, como a osteoporose. As estatinas são amplamente utilizadas para redução de níveis elevados de colesterol e estudos recentes têm revelado sua ação anabólica no osso. O objet [...] ivo deste trabalho foi avaliar a influência da deficiência estrogênica e dos tratamentos com sinvastatina ou alendronato sódico no osso alveolar em ratas. Cinqüenta e quatro ratas sofreram ovariectomia (OVX) ou cirurgia simulada ("sham"). Um mês após, os animais passaram a receber diariamente, via oral, 25 mg/kg de sinvastatina (SIN), 2 mg/kg de alendronato (ALN) ou água (controle). Trinta e cinco dias depois do início do tratamento os animais foram sacrificados, as hemimandíbulas esquerdas removidas e radiografadas em aparelho de raios X digital. Foi calculada a densidade radiográfica em tons de cinza da área de osso alveolar sob o primeiro molar mandibular e os valores foram submetidos a ANOVA, ao nível de 5%. Ratas ovariectomizadas ganharam mais peso (média ± desvio-padrão: 20,06 ± 6,68%) que as demais (12,13 ± 5,63%). Os valores de densidade radiográfica, em tons de cinza, foram menores nos animais do grupo OVX-água (183,49 ± 6,47), significantemente diferentes daqueles observados nos grupos que receberam alendronato ("sham"-ALN: 193,85 ± 3,81; OVX-ALN: 196,06 ± 5,11) e no grupo "sham"-água (193,66 ± 4,36). Outras comparações entre grupos não revelaram diferenças estatísticas. Concluiu-se que a ovariectomia reduziu a densidade óssea alveolar e que o tratamento com alendronato sódico foi eficiente para o tratamento desta situação. Abstract in english Bisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. Statins have been widely used for the treatment of hypercholesterolemia and recent studies have shown that these drugs are also capable of stimulating bone formation. The pu [...] rpose of this study was to evaluate the influence of an estrogen deficient state and the effects of simvastatin and sodium alendronate therapies on alveolar bone in female rats. Fifty-four rats were either ovariectomized (OVX) or sham operated. A month later, the animals began to receive a daily dose of simvastatin (SIN - 25 mg/kg), sodium alendronate (ALN - 2 mg/kg) or water (control) orally. Thirty-five days after the beginning of the treatment, the rats were sacrificed and their left hemimandibles were removed and radiographed using digital X-ray equipment. The alveolar radiographic density under the first molar was determined with gray-level scaling and the values were submitted to analysis of variance (a = 5%). Ovariectomized rats gained more weight (mean ± standard deviation: 20.06 ± 6.68%) than did the sham operated animals (12.13 ± 5.63%). Alveolar radiographic density values, expressed as gray levels, were lowest in the OVX-water group (183.49 ± 6.47), and differed significantly from those observed for the groups receiving alendronate (sham-ALN: 193.85 ± 3.81; OVX-ALN: 196.06 ± 5.11) and from those of the sham-water group (193.66 ± 4.36). Other comparisons between groups did not show significant differences. It was concluded that the ovariectomy reduced alveolar bone density and that alendronate was efficient for the treatment of this condition.

Ana Lia, Anbinder; Fernanda de Almeida, Prado; Marcela de Almeida, Prado; Ivan, Balducci; Rosilene Fernandes da, Rocha.

2007-09-01

146

The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats Influência da ovariectomia, da sinvastatina e do alendronato sódico no osso alveolar em ratas  

Directory of Open Access Journals (Sweden)

Full Text Available Bisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. Statins have been widely used for the treatment of hypercholesterolemia and recent studies have shown that these drugs are also capable of stimulating bone formation. The purpose of this study was to evaluate the influence of an estrogen deficient state and the effects of simvastatin and sodium alendronate therapies on alveolar bone in female rats. Fifty-four rats were either ovariectomized (OVX or sham operated. A month later, the animals began to receive a daily dose of simvastatin (SIN - 25 mg/kg, sodium alendronate (ALN - 2 mg/kg or water (control orally. Thirty-five days after the beginning of the treatment, the rats were sacrificed and their left hemimandibles were removed and radiographed using digital X-ray equipment. The alveolar radiographic density under the first molar was determined with gray-level scaling and the values were submitted to analysis of variance (a = 5%. Ovariectomized rats gained more weight (mean ± standard deviation: 20.06 ± 6.68% than did the sham operated animals (12.13 ± 5.63%. Alveolar radiographic density values, expressed as gray levels, were lowest in the OVX-water group (183.49 ± 6.47, and differed significantly from those observed for the groups receiving alendronate (sham-ALN: 193.85 ± 3.81; OVX-ALN: 196.06 ± 5.11 and from those of the sham-water group (193.66 ± 4.36. Other comparisons between groups did not show significant differences. It was concluded that the ovariectomy reduced alveolar bone density and that alendronate was efficient for the treatment of this condition.Os bisfosfonatos são empregados atualmente para o tratamento de várias doenças caracterizadas pelo aumento da reabsorção óssea, como a osteoporose. As estatinas são amplamente utilizadas para redução de níveis elevados de colesterol e estudos recentes têm revelado sua ação anabólica no osso. O objetivo deste trabalho foi avaliar a influência da deficiência estrogênica e dos tratamentos com sinvastatina ou alendronato sódico no osso alveolar em ratas. Cinqüenta e quatro ratas sofreram ovariectomia (OVX ou cirurgia simulada ("sham". Um mês após, os animais passaram a receber diariamente, via oral, 25 mg/kg de sinvastatina (SIN, 2 mg/kg de alendronato (ALN ou água (controle. Trinta e cinco dias depois do início do tratamento os animais foram sacrificados, as hemimandíbulas esquerdas removidas e radiografadas em aparelho de raios X digital. Foi calculada a densidade radiográfica em tons de cinza da área de osso alveolar sob o primeiro molar mandibular e os valores foram submetidos a ANOVA, ao nível de 5%. Ratas ovariectomizadas ganharam mais peso (média ± desvio-padrão: 20,06 ± 6,68% que as demais (12,13 ± 5,63%. Os valores de densidade radiográfica, em tons de cinza, foram menores nos animais do grupo OVX-água (183,49 ± 6,47, significantemente diferentes daqueles observados nos grupos que receberam alendronato ("sham"-ALN: 193,85 ± 3,81; OVX-ALN: 196,06 ± 5,11 e no grupo "sham"-água (193,66 ± 4,36. Outras comparações entre grupos não revelaram diferenças estatísticas. Concluiu-se que a ovariectomia reduziu a densidade óssea alveolar e que o tratamento com alendronato sódico foi eficiente para o tratamento desta situação.

Ana Lia Anbinder

2007-09-01

147

Orthodontic treatment in patient with idiopathic root resorption: A case report  

Science.gov (United States)

Multiple idiopathic external root resorption is a rare pathological condition usually detected as an incidental radiographic finding. External root resorption of permanent teeth is a multifactorial process related to several local and systemic factors. If an etiological factor cannot be identified for root resorption, the term "idiopathic" is applied. This report presents a case of multiple idiopathic apical root resorption. The condition was found in a young female patient seeking orthodontic treatment due to malocclusion. This kind of resorption starts apically and progresses coronally, causing a gradual shortening and rounding of the remaining root. Patients with this condition are not the ideal candidates for orthodontic treatment; however, the aim of this report is to describe an unusual case of idiopathic root resorption involving the entire dentition, and to present the orthodontic treatment of this patient. It describes the progress and completion of orthodontic therapy with satisfactory end results. PMID:25741832

Rey, Diego; Smit, Rosana Martínez; Gamboa, Liliana

2015-01-01

148

Using waste heat for cooling with compact resorption plants; Kompakte Resorptionsanlagen zum Kuehlen mit Abwaerme  

Energy Technology Data Exchange (ETDEWEB)

Cooling technologies gain an increasing importance in the industrialized world. Ammonia based absorption chillers can be employed for air conditioning and refrigeration, using waste heat as driving force. With using the resorption technology for ammonia based absorption chillers gas cleaning is needless. Resorption systems consist of two solvent cycles exchanging refrigerant, both with absorber, desorber and solvent heat exchanger. Plate heat exchangers or new membrane contactors used as desorber and absorber lead to compact resorption chillers. (orig.)

Weimer, Thomas [Makatec GmbH, Bondorf (Germany); Helle, Kirsten [Institut fuer Energie- und Umwelttechnik (IUTA) e.V. Energy Conversion and Energy Storage, Duisburg (Germany)

2012-03-15

149

Feline "odontolysis" in the 1920's: the forgotten histopathological study of feline odontoclastic resorptive lesions (FORL).  

Science.gov (United States)

This article reviews an historic description of feline odontoclastic resorptive lesions (FORL) from the 1920's. Hopewell-Smith describes the complete resorption process of feline permanent premolar teeth in remarkable detail, using 14 excellent photomicrographs. Resorptive lesions in cats were seen in the early part of this century, however the prevalence of this condition in domestic cats appears to have increased concurrently with certain aspects of domestication since the 1960's. PMID:10518871

Reiter, A M

1998-03-01

150

Systemic alendronate prevents resorption of necrotic bone during revascularization. A bone chamber study in rats  

OpenAIRE

Abstract Background Avascular necrosis of bone (osteonecrosis) can cause structural failure and subsequent deformation, leading to joint dysfunction and pain. Structural failure is the result of resorption of necrotic bone during revascularization, before new bone has formed or consolidated enough for loadbearing. Bone resorption can be reduced by bisphosphonates. If resorption of the necrotic bone could be reduced during the revascularization phase until sufficient new bone has formed, it wo...

Aspenberg Per; Åstrand Jörgen

2002-01-01

151

Completely resorption of autologous skull flap after orthotopic transplantation: a case report  

OpenAIRE

Autologous skull flaps were frequently used in craniotomy, and after craniotomy, autologous skull flaps need to be replanted in situ at most of the time, and complications such as infection and resorption may occur. Ultimately, resorption may result in dislocation of the autologous skull flaps. Here we describe a case of completely resorption of autologous skull flap shortly after orthotopic transplantation which required an extra cranioplasty and potential causes were discussed. Improper pro...

Yin, Jiangliu; Jiang, Yugang

2014-01-01

152

Feline odontoclastic resorptive lesions an unsolved enigma in veterinary dentistry.  

Science.gov (United States)

This article presents a comprehensive review of the literature on feline odontoclastic resorptive lesions (FORLs), including etiopathogenesis, prevalence and predisposition, classification, histopathologic appearance, diagnosis, and treatment. Approximately one-third of all domestic cats may develop FORLs during their life span, and the risk of developing FORLs increases with age. Sophisticated dental treatments promise neither cure nor permanent improvement of affected teeth. Extraction is the current treatment of choice. Research on the etiology of FORLs has not been rewarding in recent years, and the causative factors contributing to the development of FORLs are still unknown. PMID:12148312

Reiter, Alexander M; Mendoza, Krista A

2002-07-01

153

Risk factors for odontoclastic resorptive lesions in cats.  

Science.gov (United States)

A cross-sectional study evaluating potential risk factors for odontoclastic resorptive lesions (ORL) in feline teeth was conducted. Owners of 32 cats with ORL and 27 cats without ORL were interviewed regarding their respective cat's demographic characteristics, diet, and medical and dental histories. Four factors were identified as significantly associated with ORL using unconditional logistic regression. A history of dental disease (gingivitis, calculus, or periodontal disease; odds ratio [OR], 4.5); city residence (OR, 4.4); and being an exclusively indoor cat (OR, 4.5) were associated with an increased risk for ORL. Consumption of commercial treats (OR, 0.3) appeared protective for ORL. PMID:10333255

Scarlett, J M; Saidla, J; Hess, J

1999-01-01

154

STRUCTURAL CHARACTERISTICS OF THE ALVEOLAR BONE  

Directory of Open Access Journals (Sweden)

Full Text Available The morpho – functional complex that ensures the fastening of teeth to sockets, called parodontium, is constituted of the alveolar bone, alveolodental ligament, radicular cement and gingiva, which transmit the chewing forces to the resistance functional structures within the cranium’s architectonics. This work presents the structural features of the alveolar bone, both from maxilla’s alveolar process level and mandible’s alveolar edge level. The alveolar bone is generally characterized by a sponginess contained between the two compact lamellae. The weight of the spongy bone and the compact bone differs from maxilla to mandible and, at the same time, from zone to zone. Within the spongy bone, one can notice the lamellae orientated and adapted to the pressure, traction and flexion forces as a result of the chewing forces. These lamellae are being in a continuous remodeling process, in answer to the functional requests. The compact bone, better represented and stronger at the mandible by its lamellae, vestibular outside and lingual inside, has remarkable features. All of them have not only a descriptive importance, but also an applicable one.

V. Niculescu

2001-01-01

155

Ridge from Strings  

OpenAIRE

In the colour string picture with fusion and percolation it is shown that long range azimuthal-rapidity correlations (ridge) can arise from the superposition of many events with exchange of clusters of different number of strings and not from a single event. Relation of the ridge with the flow harmonics coefficients is derived. By direct Monte-Carlo simulations, in the technique previously used to calculate these coefficients, ridge correlations are calculated for AA, pA and...

Braun, M. A.; Pajares, C.; Vechernin, V. V.

2014-01-01

156

A rapid screening technique for feline odontoclastic resorptive lesions.  

Science.gov (United States)

The feline odontoclastic resorptive lesion (FORL) status (presence or absence of odontoclastic resorptive lesions) of 423 clinically healthy cats was determined based on radiographic findings in a series of full mouth radiographs (eight views). This status was compared with the FORL status based on evaluation of only two views, namely the right and left mandibular premolar and molar views. Using the FORL status of the right and left third mandibular premolars (307 and 407) alone correctly predicted overall FORL status in 93.4 per cent of cats. The sensitivity of the new technique (FORL cases correctly diagnosed as positive by the test) was 78.5 per cent, while the negative predictive value (negative FORL cases correctly diagnosed by the test) was 91.3 per cent. Overall FORL status can therefore be confidently diagnosed in nine out of 10 cats by assessing FORL status in just two teeth (307 and 407) using two films, which has benefits for the cat (less anaesthetic time and reduced exposure to radiation) and the owner (reduced cost of screening). PMID:15600270

Heaton, M; Wilkinson, J; Gorrel, C; Butterwick, R

2004-12-01

157

A Comparison of Panoramic, Periapical and Bite Wing Radiographies in Evaluation of Alveolar Bone Loss in Periodiontitis  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: The height of the alveolar bone, is normally maintained by equilibrium between bone formation and bone resorption, but in periodontal disease more destruction or lack of bone formation will reduce the alveolar bone height. However the radiography is important in diagnosis, treatment plan and detection of quality and quantity of the alveolar bone; although the type of radiography is more important. The purpose of this study is the comparison between panaromic, P.A (Parallel, Bite Wing radiographs in diagnosis of periodontitis. Methods: This study was descriptive cross-Sectional study Periapical (PA, Bitewing (B.W & Panoramic radiographic images in 32 pationent 13 male and 19 female with moderate to advanced periodontitis (mean age 38 year were taken before surgical treatment. Actual hight of defect were measured by a William's probe during surgery, the distance between cemento enamel junction (CEJ and alveolar crest were measured on radiographs using a digital vernie scale as will as. Actual measurements were compared with values taken from panoramic PA, B.W radiographs. For Data analysis Paired t test was used. Results: A total of 314 linear distances from the panoramic PA , B.W, and CEJ/BL were measured. The mean difference between panoramic and actual Measurements (0.115 and 0.28 P=(0.24-0.07, were not satistically significant (P> 0.05. The mean difference between P.A and actual measurements (0.279-0.498 P=(0.0001-0.004 showed a satistically significant difference (P< 0.05. The mean deference between BW and actual Measurements (0.576-0.613 P=(0.24-0.07 were satistically significant (P<0.05. Conclusion: Although, all forms of radiographic images showed agreement in detection of periodontal bone loss, the accuracy of panoramic radiographs was more than PA & BW radiographs'. Specially when the magnification was adjusted in panoramic radiography.

A Haerian Ardakani

2007-07-01

158

Postoperative assessment of secondary bone grafting to the alveolar cleft using three-dimensional cone beam computed tomography  

International Nuclear Information System (INIS)

Between 1995 and 2004, 282 alveolar bone grafts were performed in our department using particle cancellous bone from the iliac bone. To evaluate postoperative results the height of bone bridging was measured in a two-dimensional evaluation using dental radiographs. However, recently, with the development of three-dimension CT (3-D CT), three-dimensional evaluation of bone bridging is recommended. Therefore, since last year, we have been evaluating bone bridging using dental CT. In this paper, we report a diagnostic imaging method for bone grafting to the alveolar cleft. First, a horizontal line passing along the inferior border of the piriform aperture of the normal side on the 3-D picture is drawn and then a horizontal line passing through the tip of the labial alveolar ridge of the central incisor of the upper jaw of the normal side is drawn. Then the distance between these two horizontal lines is measured. Next, this distance is equally divided into five segments by four horizontal lines. The labial lingual width of the bone bridge of the alveolar cleft part from the axial view of the height of these four horizontal lines is compared to that of the alveolar bone of the normal side. These four compared values are called the progression of the alveolar cleft, and the results of the bone grafting are judged by these numbers. We are convinced that the results of bone grafting can be more easily understood using this progression than from the many axial views of 3-D CT. than from the many axial views of 3-D CT. (author)

159

Pulmonary alveolar microlithiasis: review of Turkish reports.  

Science.gov (United States)

Pulmonary alveolar microlithiasis is a rare disorder, only 173 cases having been reported worldwide. Fifty two cases from Turkey are reported, 49 of which have previously been described only in Turkish publications. The mean age of the patients was 27 (SD 12) years, 34 were male, and 10 were symptomless. In 40 of the 52 cases diagnosis was confirmed histopathologically. Nineteen cases were diagnosed in siblings. This high rate suggests that pulmonary alveolar microlithiasis is a familial disease, which, though rare, is for unknown reasons most common in Turkey. PMID:8493634

Ucan, E S; Keyf, A I; Aydilek, R; Yalcin, Z; Sebit, S; Kudu, M; Ok, U

1993-02-01

160

Pulmonary Alveolar Microlithiasis: A Rare Case Report  

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Full Text Available Pulmonary alveolar microlithiasis is an uncommon infiltrative pulmonary disease characterized by deposition of microliths in the alveoli. We present the case of a young adult with complaints of shortness of breath on exertion. Chest radiograph showed innumerable small, dense nodules, diffusely involving both the lungs - predominantly in the lower zones. High-resolution CT scan illustrated widespread intra-alveolar microliths, diffuse ground-glass attenuation areas, septal thickening, and black pleural lines - predominantly in the basal regions. Transbronchial biopsy confirmed the diagnosis.

Kaleem Ahmad

2013-09-01

161

Nitrogen and phosphorus resorption in a neotropical rain forest of a nutrient-rich soil.  

Science.gov (United States)

In tropical forests with nutrient-rich soil tree's nutrient resorption from senesced leaves has not always been observed to be low. Perhaps this lack of consistence is partly owing to the nutrient resorption methods used. The aim of the study was to analyse N and P resorption proficiency from tropical rain forest trees in a nutrient-rich soil. It was hypothesised that trees would exhibit low nutrient resorption in a nutrient-rich soil. The soil concentrations of total N and extractable P, among other physical and chemical characteristics, were analysed in 30 samples in the soil surface (10 cm) of three undisturbed forest plots at 'Estaci6n de Biologia Los Tuxtlas' on the east coast of Mexico (18 degrees 34' - 18 degrees 36' N, 95 degrees 04' - 95 degrees 09' W). N and P resorption proficiency were determined from senescing leaves in 11 dominant tree species. Nitrogen was analysed by microkjeldahl digestion with sulphuric acid and distilled with boric acid, and phosphorus was analysed by digestion with nitric acid and perchloric acid. Soil was rich in total N (0.50%, n = 30) and extractable P (4.11 microg g(-1) n = 30). As expected, trees showed incomplete N (1.13%, n = 11) and P (0.11%, n = 1) resorption. With a more accurate method of nutrient resorption assessment, it is possible to prove that a forest community with a nutrient-rich soil can have low levels of N and P resorption. PMID:17354446

Martínez-Sánchez, José Luis

2005-01-01

162

The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits  

DEFF Research Database (Denmark)

Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference? In contrast with other antiresorptives, such as alendronate (ALN), ODN targets only the very last step of the resorption process. We hypothesize that ODN may therefore modify the remodeling events immediately following osteoclastic resorption. These events belong to the reversal phase and include recruitment of osteoblasts, which is critical for connecting bone resorption to formation. We performed a histomorphometric study of trabecular remodeling in vertebrae of estrogen-deficient rabbits treated or not with ODN or ALN, a model where ODN, but not ALN, was previously shown to preserve bone formation. In line with our hypothesis, we found that ODN treatment compared to ALN results in a shorter reversal phase, faster initiation of osteoid deposition on the eroded surfaces, and higher osteoblast recruitment. The latter is reflected by higher densities of mature bone forming osteoblasts and an increased subpopulation of cuboidal osteoblasts. Furthermore, we found an increase in the interface between osteoclasts and surrounding osteoblast-lineage cells. This increase is expected to favor the osteoclast-osteoblast interactions required for bone formation. Regarding bone resorption itself, we show that ODN, but not ALN, treatment results in shallower resorption lacunae, a geometry favoring bone stiffness. We conclude that, compared to standard antiresorptives, ODN shows distinctive effects on resorption geometry and on reversal phase activities which positively affect osteoblast recruitment and may therefore favor bone formation.

Jensen, Pia Rosgaard; Andersen, Thomas Levin

2014-01-01

163

Ridge regression revisited  

OpenAIRE

We argue in this paper that general ridge (GR) regression implies no major complication compared with simple ridge regression. We introduce a generalization of an explicit GR estimator derived by Hemmerle and by Teekens and de Boer and show that this estimator, which is more conservative, performs better than the Hoerl and Kennard estimator in terms of a weighted quadratic loss criterion.

Boer, P. M. C.; Hafner, C. M.

2005-01-01

164

Non-Surgical Repair of Internal Resorption with MTA: A Case Report.  

Science.gov (United States)

Internal resorption is rare in permanent teeth. Treatment is usually performed through warm gutta-percha technique. If the resorptive process perforates the root, treatment may be more difficult and is usually performed via surgical approach. Non-surgical repair of a perforating internal root resorption with MTA was conducted in this case. Before repairing the resorption, a master gutta-percha point was placed in the canal to maintain negotiability of the original canal path. Then, MTA was prepared and applied with a small carrier in the resorption area and compacted. Thereafter gutta-percha was retrieved and the access cavity was closed with a temporary filling material. In the second visit, the root canal was obturated with gutta-percha and AH26 sealer using lateral compaction technique and subsequently, the crown was restored. The symptoms and signs ceased and the result was satisfactory at the 18 month follow-up visit. PMID:23130082

Mohammadi, Zahed; Yazdizadeh, Mohammad; Shalavi, Sousan

2012-01-01

165

Foliar Nutrient Dynamics and Foliar Resorption in Quercus brantii Lindley along an Elevational Gradient  

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Full Text Available Foliar mass per area (mg dm-2 -based nitrogen and phosphorus concentrations, specific leaf mass (mg dm-2 and absolute and proportional resorption in Quercus brantii was investigated along a topographic gradient from 450 to 850 m altitude. Foliar N and P concentrations in Q. brantii exhibited significant differences with respect to topographic position and sampling dates in all of the studied parameters. A sharp decrease was observed from April to September in terms of Specific Leaf Mass (SLM values. However, mass per area-based absolute and proportional N resorption was lowest at 450 m, while absolute and proportional P resorption was lowest at 850 m. Significant correlations were found between mass per area-based leaf nutrient concentration and foliar resorption except for the correlations between absolute P resorption and foliar P concentrations at 450, 650 and 750 m during full-leaf expansion and 850 m during senescence, respectively.

Ertugrul Aksekili

2007-01-01

166

Sharp Curvature of Premolar Resulting in External Apical Root Resorption of the Neighbouring Molar  

Science.gov (United States)

This case report describes an external apical root resorption resulted from the unusual root morphology of the neighbouring tooth. A 28-year-old female was referred to the department of endodontics with a complaint of intense pain in her maxillary second premolar tooth. The clinical and radiographical evaluation revealed an external apical resorption in the mesial root of the maxillary first molar, which shows close proximity to the severely curved root of the premolar. A successful root canal treatment of the premolar was performed using anticurvature filing method. However, molar tooth received no curative treatment. One-year followup of the apical external resorption did not show any progression. External apical root resorption affecting single permanent tooth may be induced from the pressure exerted during the eruption of the adjacent tooth with unusual root morphology. The preferred approach for the management of such apical resorption cases includes long-term observation and no curative treatment. PMID:22567442

Ulusoy, Özgür ?lke Atasoy

2011-01-01

167

Non-Surgical Repair of Internal Resorption with MTA: A Case Report  

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Full Text Available Internal resorption is rare in permanent teeth. Treatment is usually performed through warm gutta-percha technique. If the resorptive process perforates the root, treatment may be more difficult and is usually performed via surgical approach. Non-surgical repair of a perforating internal root resorption with MTA was conducted in this case. Before repairing the resorption, a master gutta-percha point was placed in the canal to maintain negotiability of the original canal path. Then, MTA was prepared and applied with a small carrier in the resorption area and compacted. Thereafter gutta-percha was retrieved and the access cavity was closed with a temporary filling material. In the second visit, the root canal was obturated with gutta-percha and AH26 sealer using lateral compaction technique and subsequently, the crown was restored. The symptoms and signs ceased and the result was satisfactory at the 18 month follow-up visit.

Zahed Mohammadi

2012-10-01

168

Microlitiasis alveolar pulmonar: caso clínico / Pulmonary alveolar microlithiasis: Report of one case  

Scientific Electronic Library Online (English)

Full Text Available [...] Abstract in english Pulmonary alveolar microlithiasis is an extremely rare disease characterized by intra-alveolar accumulation of calcified spherical particles (called microliths), due to a mutation of the gene encoding a membrane transport protein of the alveolar surface. Most patients are asymptomatic at diagnosis. [...] The course of the disease is slowly progressive, with development of pulmonary fibrosis and respiratory failure. The "sandstorm" pattern is the characteristic finding of this disease. We report a 39-year-old female presenting with progressive dyspnea. A chest X ray showed ground-glass opacities and a high resolution CT scan showed numerous calcified lung micronodules. A surgical lung biopsy confirmed the diagnosis of pulmonary alveolar microlithiasis.

Cristina, Fernández F; Mauricio, Salinas F; José Andrés, de Grazia K; Juan Carlos, Díaz P.

2014-05-01

169

Alveolar Macrophage Cathelicidin Deficiency in Severe Sarcoidosis  

OpenAIRE

Dysfunctional immune responses characterize sarcoidosis but the status of cathelicidin, a potent immunoregulatory and anti-microbial molecule has not been established in clinical disease activity. Alveolar macrophage cathelicidin expression was determined in biopsy-proven sarcoidosis patients classified clinically as “severe” (requiring systemic treatment) or “non-severe” (never requiring treatment). Sarcoidosis and healthy control bronchoalveolar lavage (BAL) cells were analyzed for ...

Barna, Barbara P.; Culver, Daniel A.; Kanchwala, Ali; Singh, Ravinder J.; Huizar, Isham; Abraham, Susamma; Malur, Anagha; Marshall, Irene; Kavuru, Mani S.; Thomassen, Mary Jane

2012-01-01

170

Secondary pulmonary alveolar proteinosis in hematologic malignancies.  

Science.gov (United States)

Pulmonary alveolar proteinosis (PAP), characterized by deposition of intra-alveolar PAS positive protein and lipid rich material, is a rare cause of progressive respiratory failure first described by Rosen et al. in 1958. The intra-alveolar lipoproteinaceous material was subsequently proven to have been derived from pulmonary surfactant in 1980 by Singh et al. Levinson et al. also reported in 1958 the case of 19-year-old female with panmyelosis afflicted with a diffuse pulmonary disease characterized by filling of the alveoli with amorphous material described as "intra-alveolar coagulum". This is probably the first reported case of PAP in relation to hematologic malignancy. Much progress has been made on PAP first described by Rosen which is currently classified as idiopathic or primary or autoimmune PAP. Idiopathic PAP occurs as a result of auto-antibodies directed against granulocyte-macrophage colony stimulating factor (GM-CSF) impeding the surfactant clearing function of alveolar macrophages leading to progressive respiratory failure. Whole lung lavage and GM-CSF therapy has improved outcomes in patients with idiopathic PAP. Despite major advancement in the management of hematologic malignancy and its complications, little is known about the type of PAP first described by Levinson and now known as secondary PAP; a term also used when PAP occurs due to other causes such as occupational dusts. In this article we review and analyze the limited literature available in secondary PAP due to hematologic malignancies and present a case of PAP associated with chronic lymphocytic leukemia successfully treated with bendamustine and rituximab. PMID:25300566

Chaulagain, Chakra P; Pilichowska, Monika; Brinckerhoff, Laurence; Tabba, Maher; Erban, John K

2014-12-01

171

Histological and morphometric aspects of ridge preservation with a moldable, in situ hardening bone graft substitute  

OpenAIRE

Biphasic calcium phosphates (BCP) are widely used in alveolar ridge regeneration as a porous scaffold for new bone formation. The aim of this case series was to evaluate the regenerative effect of the combination of BCP and polylactide-co-glycolide (PLGA) which can serve as a barrier membrane during bone regeneration. The study included five patients. Four months into the healing period, bone samples were collected for histological and morphometric analyses. The results of morphometric ...

Juriši? M.; Manojlovi?-Stojanoski Milica; Andri? M.; Kokovi? V.; Danilovi? Vesna; Juriši? Tamara; Brkovi? B.

2013-01-01

172

Severe root resorption resulting from orthodontic treatment: Prevalence and risk factors  

Science.gov (United States)

OBJECTIVE: To assess the prevalence of severe external root resorption and its potential risk factors resulting from orthodontic treatment. METHODS: A randomly selected sample was used. It comprised conventional periapical radiographs taken in the same radiology center for maxillary and mandibular incisors before and after active orthodontic treatment of 129 patients, males and females, treated by means of the Standard Edgewise technique. Two examiners measured and defined root resorption according to the index proposed by Levander et al. The degree of external apical root resorption was registered defining resorption in four degrees of severity. To assess intra and inter-rater reproducibility, kappa coefficient was used. Chi-square test was used to assess the relationship between the amount of root resorption and patient's sex, dental arch (maxillary or mandibular), treatment with or without extractions, treatment duration, root apex stage (open or closed), root shape, as well as overjet and overbite at treatment onset. RESULTS: Maxillary central incisors had the highest percentage of severe root resorption, followed by maxillary lateral incisors and mandibular lateral incisors. Out of 959 teeth, 28 (2.9%) presented severe root resorption. The following risk factors were observed: anterior maxillary teeth, overjet greater than or equal to 5 mm at treatment onset, treatment with extractions, prolonged therapy, and degree of apex formation at treatment onset. CONCLUSION: This study showed that care must be taken in orthodontic treatment involving extractions, great retraction of maxillary incisors, prolonged therapy, and/or completely formed apex at orthodontic treatment onset. PMID:25741825

Maués, Caroline Pelagio Raick; do Nascimento, Rizomar Ramos; Vilella, Oswaldo de Vasconcellos

2015-01-01

173

Scanning electron microscopic description of cellular activity and mineral changes in feline odontoclastic resorptive lesions.  

Science.gov (United States)

The cellular activity and changes in mineral composition of dental tissues involved in feline odontoclastic resorptive lesions were investigated. Teeth with at least 1 lesion (n = 10) were extracted from 10 different cats that were presented primarily for chronic gingivostomatitis and/or severe periodontal disease. Scanning electron microscopic methods were used to determine the presence of resorptive cells in 8 teeth while 2 teeth were evaluated for pathologic changes in dental mineral composition. Observations were complicated by the presence of organic wear on the dental surfaces, however resorptive cells could be clearly identified in feline odontoclastic resorptive lesions. Resorptive cells had morphologic features indicative of "osteoclast-like" cells or odontoclasts. Resorptive cell activity created a resorption area of darker dentin continuous with physiologic dentin. The darker dentin area seemed poorly mineralized and showed a significantly lower calcium/phosphorous ratio compared with adjacent physiologic denting in 1 tooth. A significantly higher level of magnesium combined with available carbonate ions may have increased the solubility in areas of darker dentin. PMID:11968898

Gauthier, O; Boudigues, S; Pilet, P; Aguado, E; Heymann, D; Daculsi, G

2001-12-01

174

Enhanced M1/M2 macrophage ratio promotes orthodontic root resorption.  

Science.gov (United States)

Mechanical force-induced orthodontic root resorption is a major clinical challenge in orthodontic treatment. Macrophages play an important role in orthodontic root resorption, but the underlying mechanism remains unclear. In this study, we examined the mechanism by which the ratio of M1 to M2 macrophage polarization affects root resorption during orthodontic tooth movement. Root resorption occurred when nickel-titanium coil springs were applied on the upper first molars of rats for 3 to 14 d. Positively stained odontoclasts or osteoclasts with tartrate-resistant acid phosphatase were found in resorption areas. Meanwhile, M1-like macrophages positive for CD68 and inducible nitric oxide synthase (iNOS) persistently accumulated on the compression side of periodontal tissues. In addition, the expressions of the M1 activator interferon-? and the M1-associated pro-inflammatory cytokine tumor necrosis factor (TNF)-? were upregulated on the compression side of periodontal tissues. When the coil springs were removed at the 14th day after orthodontic force application, root resorption was partially rescued. The number of CD68(+)CD163(+) M2-like macrophages gradually increased on the compression side of periodontal tissues. The levels of M2 activator interleukin (IL)-4 and the M2-associated anti-inflammatory cytokine IL-10 also increased. Systemic injection of the TNF-? inhibitor etanercept or IL-4 attenuated the severity of root resorption and decreased the ratio of M1 to M2 macrophages. These data imply that the balance between M1 and M2 macrophages affects orthodontic root resorption. Root resorption was aggravated by an enhanced M1/M2 ratio but was partially rescued by a reduced M1/M2 ratio. PMID:25344334

He, D; Kou, X; Luo, Q; Yang, R; Liu, D; Wang, X; Song, Y; Cao, H; Zeng, M; Gan, Y; Zhou, Y

2015-01-01

175

Repair of apical root resorption associated with periodontitis using a new intracanal medicament protocol.  

Science.gov (United States)

Endodontic therapy is indicated for cases of traumatic tooth dislocation associated with pulp necrosis and/or inflammatory resorption. Here we describe the management of a maxillary left lateral permanent incisor that suffered lateral luxation, leading to pulp necrosis and root resorption, in a 13-year-old boy. The traumatized tooth was treated successfully by intracanal medication with calcium hydroxide, 2% chlorhexidine gel and zinc oxide for 12 months without any need to change the dressing, followed by conventional root canal filling. The postoperative course was uneventful and a stable clinical outcome was obtained with evidence of periapical lesion repair and stabilization of the resorption process. PMID:25500930

Herrera, Daniel R; Herrera, Carlos M; Lima, Augusto R; Nagata, Juliana Y; Pereira, Andrea C; Silva, Emmanuel J; Soares, Adriana J; Gomes, Brenda P

2014-01-01

176

Mode of progression of subperiosteal resorption in the hyperparathyroidism of chronic renal failure  

Energy Technology Data Exchange (ETDEWEB)

Subperiosteal resorption in finger phalanges is usually thought to be the result of osteoclastic bone resorption on the periosteal surface of bone, progressive centripetally with creation of the serrated appearances and ''lace-like'' patterns in periosteal cortical bone. Our longitudinal microradioscopic observations in patients with secondary hyperparathyroidism of chronic renal failure have revealed evidence of another pathogenetic mechanism: by the enlargement of intracortical juxtaperiosteal resorption spaces, the remaining thin layer of bone is broken down from inside the bone, i.e., a centrifugal rather then centripetal process.

Meema, H.E.; Oreopoulos, D.G.

1983-09-01

177

An In Vitro Analysis of Wear Resistance of Commercially Available Acrylic Denture Teeth  

OpenAIRE

Posterior denture teeth wear faster than the anterior teeth, causing occlusal prematurities and loss of vertical dimension of occlusion. The loss of vertical dimension of occlusion lays more stress on the anterior alveolar ridge, which in turn increases the rate of residual ridge resorption and causes loss of alveolar ridge height in the anterior segment and compromises esthetics. Hence it is important for the clinician to choose acrylic resin teeth with high wear resistance. The objective of...

Shetty, Mallika S.; Shenoy, K. Kamalakanth

2010-01-01

178

RIDGE Multibeam Synthesis Project  

Science.gov (United States)

The RIDGE Program is a National Science Foundation initiative that promotes interdisciplinary study, scientific communication, and outreach related to all aspects of the globe-encircling, mid-ocean ridge system. The RIDGE Multibeam Synthesis Project site provides free access to downloadable multibeam bathymetric images and datasets of suboceanic ridges and vents. From either a hotlinked world map or a drop-down menu, users can specify the feature of interest - from the Reykjanes Ridge to the Shona Hotspot to the Galapagos Spreading Center - then progressively zoom to finer grid scales. The bathymetric images are depicted at different node spacings (100 m to 1500m) and grids are supported by the appropriate metadata. The images are also accompanied by ping data (including ship tracks) and other related data, which may include coaxial segment perspective images or isochron interpretation maps. Also, for many of the grids the user can specify subsample regions or retrieve contour areas of subregions. Links throughout the site include those to the main RIDGE page, a gallery of coaxial images, information on Served Data Formats, and the Principal Investigators involved with the Project.

179

Ridge jump process in Iceland  

OpenAIRE

Eastward ridge jumps bring the volcanic zones of Iceland back to the centre of the hotspot in response to the absolute westward drift of the Mid-Atlantic Ridge. Mantellic pulses triggers these ridge jumps. One of them is occurring in Southern Iceland, whereas the exact conditions of the last ridge jump in Northern Iceland remain controversial. The diachronous evolution of these two parts of Iceland may be related to the asymmetric plume-ridge interaction when comparing Northern and Southern I...

Garcia, Sebastian

2010-01-01

180

Characteristic aspects of alveolar proteinosis diagnosis Aspectos característicos do diagnóstico da proteinose alveolar  

Directory of Open Access Journals (Sweden)

Full Text Available Alveolar proteinosis is an uncommon pulmonary disease characterized by an accumulation of surfactant in terminal airway and alveoli, thereby impairing gas exchange and engendering respiratory insufficiency in some cases. Three clinically and etiologically distinct forms of pulmonary alveolar proteinosis are recognized: congenital, secondary and idiopathic, the latter corresponding to 90% of the cases. In this case report we present a young male patient that was diagnosed with alveolar proteinosis. Computed tomography of the thorax, bronchoscopy and transbronchial biopsy were performed. The histopathologic aspect was characteristic. The patient was discharged in good health conditions and remains asymptomatic to date.Proteinose alveolar é uma doença pulmonar incomum caracterizada pelo acúmulo de surfactante nas vias aéreas terminais e nos alvéolos, alterando a troca gasosa e, em alguns casos, promovendo insuficiência respiratória. Três formas clínicas e etiologicamente distintas de proteinose alveolar são reconhecidas: congênitas, secundárias e idiopáticas (mais de 90% dos casos são de etiologia idiopática. Neste relato, apresentamos um homem jovem que foi diagnosticado com proteinose pulmonar. Tomografia computadorizada de tórax, broncoscopia e biópsia transbrônquica foram realizadas. O aspecto histopatológico foi característico. O paciente teve alta, com boas condições de saúde, e encontra-se assintomático nos dias de hoje.

Thiago Prudente Bártholo

2012-02-01

181

Characteristic aspects of alveolar proteinosis diagnosis / Aspectos característicos do diagnóstico da proteinose alveolar  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese Proteinose alveolar é uma doença pulmonar incomum caracterizada pelo acúmulo de surfactante nas vias aéreas terminais e nos alvéolos, alterando a troca gasosa e, em alguns casos, promovendo insuficiência respiratória. Três formas clínicas e etiologicamente distintas de proteinose alveolar são reconh [...] ecidas: congênitas, secundárias e idiopáticas (mais de 90% dos casos são de etiologia idiopática). Neste relato, apresentamos um homem jovem que foi diagnosticado com proteinose pulmonar. Tomografia computadorizada de tórax, broncoscopia e biópsia transbrônquica foram realizadas. O aspecto histopatológico foi característico. O paciente teve alta, com boas condições de saúde, e encontra-se assintomático nos dias de hoje. Abstract in english Alveolar proteinosis is an uncommon pulmonary disease characterized by an accumulation of surfactant in terminal airway and alveoli, thereby impairing gas exchange and engendering respiratory insufficiency in some cases. Three clinically and etiologically distinct forms of pulmonary alveolar protein [...] osis are recognized: congenital, secondary and idiopathic, the latter corresponding to 90% of the cases. In this case report we present a young male patient that was diagnosed with alveolar proteinosis. Computed tomography of the thorax, bronchoscopy and transbronchial biopsy were performed. The histopathologic aspect was characteristic. The patient was discharged in good health conditions and remains asymptomatic to date.

Thiago Prudente, Bártholo; José Gustavo, Pugliese; Luiz Carlos Aguiar, Vaz; Cláudia Henrique da, Costa; Rogério, Rufino.

2012-02-01

182

Bimaxillary protrusion with an atrophic alveolar defect: orthodontics, autogenous chin-block graft, soft tissue augmentation, and an implant.  

Science.gov (United States)

Bimaxillary protrusion in a 28-year-old woman was complicated by multiple missing, restoratively compromised, or hopeless teeth. The maxillary right central incisor had a history of avulsion and replantation that subsequently evolved into generalized external root resorption with Class III mobility and severe loss of the supporting periodontium. This complex malocclusion had a discrepancy index of 21, and 8 additional points were scored for the atrophic dental implant site (maxillary right central incisor). The comprehensive treatment plan included extraction of 4 teeth (both maxillary first premolars, the maxillary right central incisor, and the mandibular right first molar), orthodontic closure of all spaces except for the future implant site (maxillary right central incisor), augmentation of the alveolar defect with an autogenous chin-block graft, enhancement of the gingival biotype with a connective tissue graft, and an implant-supported prosthesis. Orthodontists must understand the limitations of bone grafts. Augmented alveolar defects are slow to completely turn over to living bone, so they are usually good sites for implants but respond poorly to orthodontic space closure. However, postsurgical orthodontic treatment is often indicated to optimally finish the esthetic zone before placing the final prosthesis. The latter was effectively performed for this patient, resulting in a total treatment time of about 36 months for comprehensive interdisciplinary care. An excellent functional and esthetic result was achieved. PMID:25533077

Chiu, Grace S C; Chang, Chris H N; Roberts, W Eugene

2015-01-01

183

Intracellular particle dissolution in alveolar macrophages.  

OpenAIRE

Aerosol particles deposited in the lungs that are not readily soluble in the epithelial lining fluid will be phagocytized by alveolar macrophages (AM). Inside the phagolysosomal vacuole, the constituents of the plasma allow dissolution of a variety of compounds at a higher rate than dissolution in extracellular lung fluids. Chelator concentration and a pH value of about 5 were found to control intracellular particle dissolution (IPD). Hence, IPD is the initial step of translocation of dissolv...

Kreyling, W. G.

1992-01-01

184

Phagocytic properties of lung alveolar wall cells  

Directory of Open Access Journals (Sweden)

Full Text Available For the purpose to define the mechanism of heavy metal intoxication by inhalation, morphologic observations were made on rat lungs after nasal instillation of iron colloid particles of positive and negative electric charges. Histochemical observation was also made on the liver and spleen of these animals. The instilled iron colloid particles reach the alveolar cavity easily, as can be seen in the tissue sections stained by Prussian blue reaction. Alveolar macrophages do take up them avidly both of positive and negative charges, though much less the positive particles than negative ones. In contrast, the alveolar epithelial cells take up solely positive particles by phagocytosis but not negative ones. Electron microscope observation revealed that the positive particles are ingested by Type I epithelial cells by pinocytosis and by Type II cells by phagocytosis as well. Then the iron colloid particles are transferred into the basement membrane by exocytosis. Travelling through the basement membrane they are again taken up by capillary endothelial cells by phagocytosis. Some particles were found in the intercellular clefts of capillary endothelial cells but not any iron colloid particles in the intercellular spaces of epithelial cells and in the capillary lumen. However, the liver and spleen tissues of the animals given iron colloid showed a strong positive iron reaction. On the basis of these observations, the mechanism of acute intoxication by inhaling heavy metal dusts like lead fume is discussed from the view point of selective uptake of alveolar epithelial and capillary endothelial cells for the particles of the positive electric cha'rge.

Tanaka,Akisuke

1974-04-01

185

Alveolar Soft Part Sarcoma: A Rare Diagnosis  

OpenAIRE

Alveolar soft-part sarcoma (ASPS) is an extremely rare disease arising from connective tissues with a propensity for recurrence and metastasis. Clinically, it can be confused with hemangioma or arterio-venous malformations. Thus, a high index of suspicion and histopathological examination are required to make a definitive diagnosis. We report a case of recurrent ASPS in a young female with multiple sites involvement without any features of metastasis who has been treated with excision of the ...

Sarkar, Priyanka; Mukherjee, Subhabrata; Saha, Makhan Lal; Biswas, Rabi Sankar

2013-01-01

186

Tannin mediated alveolar macrophage protein phosphorylation.  

Science.gov (United States)

Experiments were designed to determine if cotton bract tannin, a component of cotton mill dust, would promote the phosphorylation of alveolar macrophage proteins in doses potentially achievable in vivo. Rabbit alveolar macrophages were loaded with 32PO4 and challenged with various doses of tannin for time periods ranging from two seconds to 120 minutes. Changes in protein phosphorylation began after two seconds and were maximal at five to fifteen minutes. Dose response studies using an exposure time of one hour showed phosphorylation changes began at 1 micrograms/mL and were maximal at 10 to 30 micrograms/mL. Phosphorylation changes were similar to but not identical to those induced by the protein kinase C activator, phorbol myristate acetate (PMA). Calcium ionophore, A-23187 had no clear effect either alone or in conjunction with PMA. These results indicate that cotton bract tannin is able to rapidly promote protein phosphorylation of alveolar macrophages at doses potentially achievable in vivo. Other mechanisms in addition to those of protein kinase C appear to be involved in this protein phosphorylation process. PMID:2505060

Hempel, S L; Rohrbach, M S

1989-04-11

187

Vitamin B1 resorption. X.Changes in thiamine resorption in the small intestine of chickens and rats treated with somatotropic hormone  

International Nuclear Information System (INIS)

A trial was carried out with broiler chickens aged one month and Wistar male albino rats of mean liveweight of 207 g. The chickens were intramusculary injected with somatotropic hormone (STH), Sotropin H (DDR) 2 units/1O0 g liveweight for 3 successive days and the rats - 4 days. Intestine alkaline phosphatase activity was determined for a separate group of chickens post hormone injection. The resorption of 35S-thiamine, introduced in bilaterally ligated duodenum, 30 ?Ci/kg liveweight, was studied in chickens; in rats -the resorption of thiamine chloride (non radioactive), 20O ?g dissolved in 3 ml volume, introduced in the lupen of the entire small intestine (duodenum, jejunum, ileum) bilaterally ligated. It was found that STH enhanced thiamine both in chickens and rats (p 1 resorption in the small intestine (2, 3). Thiamine resorption depends on the activity of metabolic processes in small intestine epithelium. This is confirmed by data on the effect of sodium fluoride (NaF) and monoiodoacetic acid (MIAA). Thiamine resorption is depressed when 10-2M or 1O-3M MIAA are jointly introduced in the lumen of the intestine. When the action of NaF and MIAA takes place against the background oIAA takes place against the background of STH action, then thiamine resorption goes up and equal that of the control group. NaF inhibits small intestine respiratory activity. These results are interpreted in the sense that the active thiamine transport is influenced by STH which restores the enzyme and respiratory activity of intestine epithelial cells. (author)

188

A case report of gingival enlargement associated with invasive cervical resorption.  

Science.gov (United States)

SUMMARY Invasive cervical resorption (ICR) is a rare external dental resorption with unknown etiology; it progresses asymptomatically in the cervical area of the permanent teeth. Lesions are mostly misdiagnosed as internal resorption or caries, which leads to erroneous treatments. This case report presents the clinical and radiological diagnosis, as well as the results of treatment and 3-year follow-up in a 50-year-old female patient with gingival enlargement associated with ICR in tooth No. 25. Granulation tissue was removed by accessing the cervical resorption area through a flap operation. Following the endodontic treatment, the tooth was restored using composite resin and the hyperplastic lesion was excised. In conclusion, it should be kept in mind that clinical, radiological, and pathological evaluation in the differential diagnosis of localized hyperplastic lesions in the gingiva is of importance and that ICR could play a role in the etiology of these lesions. PMID:25136907

Bal, Mv; Y?ld?r?m, ?; Saygun, I

2015-01-01

189

Resorption of radionuclides through the surface of thermal burns and problems of decontamination  

International Nuclear Information System (INIS)

Resorption of sup(137)Cs, sup(89)Sr, sup(131)I, sup(241)Am during thermal burns of 1-3 degrees and choice of a decontamination method used simultaneously for decontamination and disinfection of burn wounds were studied. It is shown that a degree of burns effects in a certain form on skin penetrability: through burns of 1-2 degrees the resorption increases 1 5-3 times, through burns of the thir degree the resorption decreases slightly as compared to the resorption through intact skin. High efficiency of 3% soap solution for removing radionuclides from burn csurfae of skin has been established. For burns accompanied with the disturbance of epidermis integrality, when considerable absorption of radionuclides is possible, decontamination must be accomplished as soon and complete as possible

190

External root resorption following partial-thickness connective tissue graft placement: a case report.  

Science.gov (United States)

We report an unusual case of external root resorption (ERR) that developed in a 37-year-old black male approximately 1 year following routine partial thickness connective tissue graft surgery. The lesion was accessed via flap surgery, thoroughly root planed, and the mucoperiosteal flap replaced. The site healed uneventfully and the patient has been closely observed for over 1 year without symptoms or recurrence of the resorptive lesion and the affected tooth remained vital. Clinicians performing partial-thickness connective tissue grafts should be alert to the possible occurrence of root resorption over extended periods of time. The authors speculate that retention of the donor periosteum with placement on the recipient dentin and root biomodification may limit the resorptive response following connective tissue graft procedures to treat tooth root recession. PMID:11922264

Hokett, Steven D; Peacock, Mark E; Burns, William T; Swiec, Gary D; Cuenin, Michael F

2002-03-01

191

Immunoassay for urinary pyridinoline: the new marker of bone resorption.  

Science.gov (United States)

Urinary pyridinoline (Pyd) and deoxypyridinoline (Dpd) are markers of bone resorption that are elevated above normal in subjects with metabolic bone disease. Total Pyd and Dpd, both free and peptide-bound forms, can be measured by HPLC after hydrolysis and cellulose chromatography. Since free Pyd is the major component of total Pyd in urine, we developed an immunoassay using free Pyd as an immunogen. This assay is much easier to perform than HPLC, requires no sample preparation, and correlates well with total Pyd measurement by HPLC (r = 0.97) and with urinary hydroxyproline (r = 0.90). The antiserum reacts most strongly with free Pyd and Dpd and minimally with glycosylated and large peptide-bound forms. The sensitivity of the Pyd immunoassay is less than 25 nM. The intraassay CV is 5-10%; the interassay CV is 10-15%. Analytic recovery studies indicated negligible sample interference. Furthermore, measurement of the Pyd in the same individuals over a 30 day time period exhibited minimal day-to-day variation. Thus, the Pyd immunoassay provides a rapid and easy method for evaluation of Pyd in urine. Pyd immunoassay may serve as a practical method of screening for metabolic bone disease and for monitoring therapeutic treatment. PMID:8511991

Seyedin, S M; Kung, V T; Daniloff, Y N; Hesley, R P; Gomez, B; Nielsen, L A; Rosen, H N; Zuk, R F

1993-05-01

192

Ion transporters involved in acidification of the resorption lacuna in osteoclasts  

DEFF Research Database (Denmark)

Osteoclasts possess a large amount of ion transporters, which participate in bone resorption; of these, the vacuolar-adenosine trisphosphatase (V-ATPase) and the chloride-proton antiporter ClC-7 acidify the resorption lacuna. However, whether other ion transporters participate in this process is currently not well understood. We used a battery of ion channel inhibitors, human osteoclasts, and their subcellular compartments to perform an unbiased analysis of the importance of the different ion transporters for acidification of the resorption lacuna in osteoclasts. CD14(+) monocytes from human peripheral blood were isolated, and mature osteoclasts were generated using RANKL and M-CSF. The human osteoclasts were (1) used for acridine orange assays for evaluation of lysosomal acidification, (2) used for bone resorption assays, (3) used for generation of osteoclasts membranes for acid influx experiments, or (4) lysed in trizol for mRNA isolation for Affymetrix array analysis. Inhibitors targeted toward most of theion transporters showed low potency in the acidification-based assays, although some inhibitors, such as carbonic anhydrase II and the sodium-hydrogen exchanger (NHE) inhibitors, reduced resorption potently. In contrast, inhibitors targeted at V-ATPase and ClC-7 potently inhibited both acidification and resorption, as expected. We here show evidence that acidification of the resorption lacuna is mainly mediated by V-ATPase and ClC-7. Furthermore, a group of other ion transporters, including carbonic anhydrase II, the NHEs, and potassium-chloride cotransporters, are all involved in resorption but do not seem to directly be involved in acidification of the lysosomes Udgivelsesdato: 2008/9

Henriksen, K.; Sorensen, M.G.

2008-01-01

193

Osteoclast-specific inactivation of the Integrin-Linked Kinase (ILK) inhibits bone resorption  

OpenAIRE

Bone resorption requires the adhesion of osteoclasts to extracellular matrix (ECM) components, a process mediated by the ?v?3 integrin. Following engagement with the ECM, integrin receptors signal via multiple downstream effectors, including the Integrin-Linked Kinase (ILK). In order to characterize the physiological role of ILK in bone resorption, we generated mice with an osteoclast-specific Ilk gene ablation by mating mice with a floxed Ilk allele with TRAP-Cre transgenic mice. The TRAP-...

Dossa, Tanya; Arabian, Alice; Windle, Jolene J.; Dedhar, Shoukat; Teitelbaum, Steven L.; Ross, F. Patrick; Roodman, G. David; St-arnaud, Rene?

2010-01-01

194

Divalent cation ionophores stimulate resorption and inhibit DNA synthesis in cultured fetal rat bone  

Energy Technology Data Exchange (ETDEWEB)

Two divalent cation ionophores, A23187 and Ionomycin, which are selective for calcium, stimulated the resorption of fetal rat long bones in organ culture at 0.1 to 1 micromolar but not at higher concentrations. Both agents inhibited DNA synthesis at concentrations that stimulated resorption. These results might explain the differences in ionophore effects on bone previously reported, and they imply that cell replication is not required for osteoclast formation in fetal rat long bone cultures.

Lorenzo, J.A.; Raisz, L.G.

1981-06-01

195

Reduction of instability-induced bone resorption using bisphosphonates: high doses are needed in rats.  

OpenAIRE

Bone resorption associated with prosthetic loosening can be reduced by giving bisphosphonates since they bind to bone surfaces and inactivate osteoclasts when bisphosphonate-containing bone is resorbed. During loosening, an increase in osteoclastic activity can be triggered by mechanical instability, fluid pressure or wear particles. We used a rat model in which a titanium surface can be made to slide over a bone surface and cause instability-induced bone resorption. 111 rats were operated on...

A?strand, Jo?rgen; Aspenberg, Per

2002-01-01

196

Response of Bone Resorption Markers to Aristolochia longa Intake by Algerian Breast Cancer Postmenopausal Women  

OpenAIRE

Aristolochia longa is widely used in traditional medicine in Algeria to treat breast cancer. The aim of the present study was to investigate the response of bone resorption markers to A. longa intake by Algerian breast cancer postmenopausal women. According to the A. longa intake, breast cancer patients were grouped into A. longa group (Al) (n = 54) and non-A. longa group (non-Al) (n = 24). 32 women constituted the control group. Bone resorption markers (from urine) pyridinoline (PYD) and deo...

Bachir Benarba; Boumedienne Meddah; Aicha Tir Touil

2014-01-01

197

Predisposing factors to severe external root resorption associated to orthodontic treatment  

OpenAIRE

OBJECTIVE: The aim of this study was to evaluate predisposing factors among patients who developed moderate or severe external root resorption (Malmgren's grades 3 and 4), on the maxillary incisors, during fixed orthodontic treatment in the permanent dentition. METHODS: Ninety-nine patients who underwent orthodontic treatment with fixed edgewise appliances were selected. Patients were divided into two groups: G1 - 50 patients with no root resorption or presenting only apical irregularities (M...

Gracemia Vasconcelos Picanço; Karina Maria Salvatore de Freitas; Rodrigo Hermont Cançado; Fabricio Pinelli Valarelli; Paulo Roberto Barroso Picanço; Camila Pontes Feijão

2013-01-01

198

Matrix metalloproteinase-7–dependent release of tumor necrosis factor-? in a model of herniated disc resorption  

OpenAIRE

Herniated disc (HD), one of the major causes of low back pain, is often resolved spontaneously without surgical intervention. Resorption is associated with a marked increase in infiltrating macrophages, and the matrix metalloproteinases (MMP) MMP-3 and MMP-7 have been implicated in this phenomenon. We developed a murine organ culture model in which intact intervertebral discs were cocultured with peritoneal macrophages to investigate the role of MMPs in HD resorption. Using macrophages isolat...

Haro, Hirotaka; Crawford, Howard C.; Fingleton, Barbara; Shinomiya, Kenichi; Spengler, Dan M.; Matrisian, Lynn M.

2000-01-01

199

Directed Expression of Cre in Alveolar Epithelial Type 1 Cells  

OpenAIRE

Pulmonary alveolar epithelium is comprised of two morphologically and functionally distinct cell types, alveolar epithelial type (AT) I and AT2 cells. Genetically modified mice with cell-specific Cre/loxP-mediated knockouts of relevant genes in each respective cell type would be useful to help elucidate the relative contributions of AT1 versus AT2 cells to alveolar homeostasis. Cre has previously been efficiently expressed in AT2 cells in mouse lung with the surfactant protein (SP)-C promoter...

Flodby, Per; Borok, Zea; Banfalvi, Agnes; Zhou, Beiyun; Gao, Danping; Minoo, Parviz; Ann, David K.; Morrisey, Edward E.; Crandall, Edward D.

2009-01-01

200

Pulmonary Alveolar Proteinosis in Children: A case series  

OpenAIRE

Pulmonary Alveolar Proteinosis(PAP) is a rare disease of unknown etiology, characterized by the accumulation of proteinoceous material in the alveoli that is rich in lipid and is positive on periodic acid-Schiff(PAS) stain. PAP is rare in children. Two forms are encountered in pediatric practice: congenital alveolar proteinosis (CAP) and a later–onset form that is generally less severe. Broncho-alveolar lavage is the key to diagnosis. Therapeutic lung lavages are the only effective treatmen...

seyyed Ahmad Tabatabaei; abdollah karimi; Sedigheh Rafiee Tabatabaei; Radpay, B.; Farzaneh Jadali

2010-01-01

201

Diffuse alveolar hemorrhage as a manifestation of Behçet disease  

OpenAIRE

Diffuse alveolar hemorrhage (DAH) is a rare life-threatening condition which refers to the presence of red blood cells within alveoli deriving from hemorrhage originating in the pulmonary microvasculature. It differs from alveolar filling, in which blood cells derive from localized bleeding, usually of bronchial origin. DAH may be part of diffuse alveolar injury of any origin. DAH should be considered a medical emergency due to the significant morbidity and mortality associated with respirato...

Grosso, V.; Boveri, E.; Bogliolo, L.; Montecucco, C.; Caporali, R.

2013-01-01

202

External root resorption after orthodontic treatment: a study of contributing factors  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study was to examine the patient- and treatment-related etiologic factors of external root resorption. This study consisted of 163 patients who had completed orthodontic treatments and taken the pre- and post-treatment panoramic and lateral cephalometric radiographs. The length of tooth was measured from the tooth apex to the incisal edge or cusp tip on the panoramic radiograph. Overbite and overjet were measured from the pre- and post-treatment lateral cephalometric radiographs. The root resorption of each tooth and the factors of malocclusion were analyzed with an analysis of variance. A paired t test was performed to compare the mean amount of root resorption between male and female, between extraction and non-extraction cases, and between surgery and non-surgery groups. Correlation coefficients were measured to assess the relationship between the amount of root resorption and the age in which the orthodontic treatment started, the degree of changes in overbite and overjet, and the duration of treatment. Maxillary central incisor was the most resorbed tooth, followed by the maxillary lateral incisor, the mandibular central incisor, and the mandibular lateral incisor. The history of tooth extraction was significantly associated with the root resorption. The duration of orthodontic treatment was positively correlated with the amount of root resorption. These findings show that orthodontic treatment should be carefully performed in patients who need the treatment for a long period and with a pre-treatment extraction of teeth.

Jung, Yun Hoa; Cho, Bong Hae [School of Dentistry, Pusan National University, Pusan (Korea, Republic of)

2011-03-15

203

Role of carbonic anhydrase in bone resorption induced by prostaglandin E2 in vitro  

Science.gov (United States)

The possible role of carbonic anhydrase in bone resorption induced by prostaglandin E2 (PGE2) was studied using an in vitro neonatal mouse calvarial culture system. PGE2 (10 to the -6th M) was effective in stimulating resorption, as assessed by calcium release into culture media. This enhanced resorption was accompanied by significant increases in calvarial carbonic anhydrase activity over control values at 48 and 96 h. At 48 h, bones treated with PGE2 had 20 percent more carbonic anhydrase activity than controls. By 96 h, treated bones contained 79 percent more carbonic anhydrase activity than controls. PGE2-induced bone resorption was inhibited by the carbonic anhydrase inhibitor acetazolamide in a dose-dependent fashion from 10 to the -5th to 10 to the -4th M with 77 percent inhibition observed at 10 to the -4th M. The acetazolamide analogue CL 13,850 (N-t-butylacetazolamide), which does not inhibit carbonic anhydrase, failed to inhibit PGE2-induced resorption. These results are consistent with the hypothesis that carbonic anhydrase is a necessary component of the osteoclastic bone resorptive mechanism.

Hall, G. E.; Kenny, A. D.

1985-01-01

204

Leptin regulation of bone resorption by the sympathetic nervous system and CART.  

Science.gov (United States)

Bone remodelling, the mechanism by which vertebrates regulate bone mass, comprises two phases, namely resorption by osteoclasts and formation by osteoblasts; osteoblasts are multifunctional cells also controlling osteoclast differentiation. Sympathetic signalling via beta2-adrenergic receptors (Adrb2) present on osteoblasts controls bone formation downstream of leptin. Here we show, by analysing Adrb2-deficient mice, that the sympathetic nervous system favours bone resorption by increasing expression in osteoblast progenitor cells of the osteoclast differentiation factor Rankl. This sympathetic function requires phosphorylation (by protein kinase A) of ATF4, a cell-specific CREB-related transcription factor essential for osteoblast differentiation and function. That bone resorption cannot increase in gonadectomized Adrb2-deficient mice highlights the biological importance of this regulation, but also contrasts sharply with the increase in bone resorption characterizing another hypogonadic mouse with low sympathetic tone, the ob/ob mouse. This discrepancy is explained, in part, by the fact that CART ('cocaine amphetamine regulated transcript'), a neuropeptide whose expression is controlled by leptin and nearly abolished in ob/ob mice, inhibits bone resorption by modulating Rankl expression. Our study establishes that leptin-regulated neural pathways control both aspects of bone remodelling, and demonstrates that integrity of sympathetic signalling is necessary for the increase in bone resorption caused by gonadal failure. PMID:15724149

Elefteriou, Florent; Ahn, Jong Deok; Takeda, Shu; Starbuck, Michael; Yang, Xiangli; Liu, Xiuyun; Kondo, Hisataka; Richards, William G; Bannon, Tony W; Noda, Masaki; Clement, Karine; Vaisse, Christian; Karsenty, Gerard

2005-03-24

205

Effects of berberine on differentiation and bone resorption of osteoclasts derived from rat bone marrow cells  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To observe the effects of berberine on osteoclastic differentiation and bone resorption action in vitro, and to investigate the cellular mechanism of its inhibitory effects on bone resorption.Methods: The multinucleated osteoclasts (MNCs were derived by 1,25-dihydroxyvitamin D3 and dexamethasone from bone marrow cells in the coculture system with primary osteoblastic cells. The tartrate-resistant acid phosphatase (TRAP staining and image analysis of bone resorption pit on dental slices were used to identify osteoclast. The activity of TRAP was measured by p-nitrophenyl sodium phosphate assay. The bone resorption pit area on the bone slices formed by osteoclasts was measured by computer image processing.Results: At the concentrations of 0.1, 1 and 10 ?mol/L, berberine dose-dependently suppressed the formation of TRAP-positive multinucleated cells, the TRAP activity and the osteoclastic bone resorption. The strongest inhibitory effect was exhibited at the concentration of 10 ?mol/L, with the inhibiting rate of 60.45%, 42.12% and 72.69% respectively.Conclusion: Berberine can decrease bone loss through inhibition of osteoclast formation, differentiation and bone resorption.

Peng WEI

2009-04-01

206

Transforming growth factor beta inhibits bone resorption in fetal rat long bone cultures.  

Science.gov (United States)

TGF-beta 1 is a polypeptide that is abundant in bone matrix, is produced by bone cells, and modulates proliferation and differentiated functions of osteoblastic cells in vitro. TGF-beta 2 is a closely related polypeptide that was originally isolated from bone matrix. TGF-beta 1 has been shown previously to stimulate prostaglandin production in cultures of neonatal mouse calvariae, which causes these bones to resorb. We found similar effects with TGF-beta 2. In comparison, TGF-beta 1 and TGF-beta 2 failed to stimulate bone resorption in fetal rat long bone cultures during a 3-d incubation period in concentrations up to 50-100 times greater than those capable of inducing bone resorption in calvariae. Incubation with TGF-beta 1 for a further 3 d decreased bone resorption up to 30%. Moreover, bone resorption induced by the bone-resorbing agents IL 1 and 1,25-dihydroxyvitamin D3 was partially or completely inhibited by TGF-beta 1 and TGF-beta 2 during the second half of the 6-d incubation period. Inhibition of DNA synthesis with hydroxyurea inhibited bone resorption in long bones in a similar pattern to that seen with TGF-beta 1. The inhibitory effects of TGF-beta 1 and TGF-beta 2 on bone resorption in long bone cultures may therefore be due to inhibition of osteoclast precursor proliferation. PMID:3165385

Pfeilschifter, J; Seyedin, S M; Mundy, G R

1988-08-01

207

Evolución en el tratamiento de la atrofia alveolar  

Directory of Open Access Journals (Sweden)

Full Text Available Con el objetivo de describir la evolución del tratamiento de la atrofia alveolar se realiza una revisión bibliográfica actualizada de 25 referencias, se destacan las vestibuloplastias, injertos óseos, biomateriales, implantes endóseos, regeneración ósea guiada y la distracción ósea, que corrigen o compensan la atrofia alveolar con sus indicaciones, ventajas y desventajas.An updated literature review of 25 references was made to describe the development in the treatment of dental alveolar atrophy. Some procedures that correct or compensate alveolar atrophies such as vestibuloplasty, bone grafting, biomaterials, endo-bone implants, guided bone regeneration and bone distraction. Their indications, advantages and disadvantages are set forth.

Oscar García-Roco Pérez

2002-08-01

208

Oak Ridge national reservation  

International Nuclear Information System (INIS)

The US Department of Energy (DOE) Oak Ridge Reservation is located on 37 000 acres in east Tennessee. The Oak Ridge facilities include the Oak Ridge National Laboratory (ORNL), the Y-12 National Security Complex and the East Tennessee Technology Park (ETTP - originally built as a uranium enrichment facility for defence programmes and originally named 'The Oak Ridge Gaseous Diffusion Plant'. After World War II this plant was renamed Oak Ridge K-25 Site and produced enriched uranium for the commercial nuclear power industry from 1945 to 1985. It was renamed ETTP in 1987. The situation at this site is characterized by hundreds of contaminated buildings in deteriorating conditions. The water table is shallow at the site implying a short travel time of the contaminants. The overall strategy for cleanup of the Reservation is based on surface water considerations as the Reservation encompasses five distinct watersheds. The cleanup strategy is a risk-based approach that focuses first on those contaminant sources that are the greatest contributors of risk. The watershed approach is used to determine which sources are the worst contributors and therefore should be cleaned up as early as possible. At the end of site cleanup, planned by 2015, the Oak Ridge National Laboratory will continue to operate as a world-class research facility. Y-12 will continue to operate, fulfilling its national security mission. As cleanup of the East Tennessee Technology Park is completed DOE will tre Technology Park is completed DOE will transfer ownership of the uncontaminated buildings to the Community Reuse Organization of East Tennessee (CROET) which in turn will lease this property for immediate private industrial use. To further refine the overall cleanup strategy, a prioritization system has been developed to help guide decisions where investments should be made. The general priorities are as follows: (a) Mitigate immediate onsite and offsite risks; (b) Reduce offsite migration of contaminants; (c) Remediate sources of surface water and groundwater contamination; (d) Remediate remaining onsite contamination; (e) Demolish excess facilities

209

Particle-induced indentation of the alveolar epithelium caused by surface tension forces  

OpenAIRE

Physical contact between an inhaled particle and alveolar epithelium at the moment of particle deposition must have substantial effects on subsequent cellular functions of neighboring cells, such as alveolar type-I, type-II pneumocytes, alveolar macrophage, as well as afferent sensory nerve cells, extending their dendrites toward the alveolar septal surface. The forces driving this physical insult are born at the surface of the alveolar air-liquid layer. The role of alveolar surfactant submer...

Mijailovich, S. M.; Kojic, M.; Tsuda, A.

2010-01-01

210

Effect of Ridge-Ridge Interactions in Crumpled Thin Sheets  

OpenAIRE

We study whether and how the energy scalings based on the single-ridge approximation are revised in an actual crumpled sheet; namely, in the presence of ridge-ridge interactions. Molecular Dynamics Simulation is employed for this purpose. In order to improve the data quality, modifications are introduced to the common protocol. As crumpling proceeds, we find that the average storing energy changes from being proportional to one-third of the ridge length to a linear relation,...

Liou, Shiuan-fan; Lo, Chun-chao; Chou, Ming-han; Hsiao, Pai-yi; Hong, Tzay-ming

2013-01-01

211

Nostril Base Augmentation Effect of Alveolar Bone Graft  

Directory of Open Access Journals (Sweden)

Full Text Available Background The aims of alveolar bone grafting are closure of the fistula, stabilization ofthe maxillary arch, support for the roots of the teeth adjacent to the cleft on each side.We observed nostril base augmentation in patients with alveolar clefts after alveolar bonegrafting. The purpose of this study was to evaluate the nostril base augmentation effect ofsecondary alveolar bone grafting in patients with unilateral alveolar cleft.Methods Records of 15 children with alveolar clefts who underwent secondary alveolar bonegrafting with autogenous iliac cancellous bone between March of 2011 and May of 2012 werereviewed. Preoperative and postoperative worm’s-eye view photographs and reconstructedthree-dimensional computed tomography (CT scans were used for photogrammetry. Thedepression of the nostril base and thickness of the philtrum on the cleft side were measuredin comparison to the normal side. The depression of the cleft side pyriform aperture wasmeasured in comparison to the normal side on reconstructed three-dimensional CT.Results Significant changes were seen in the nostril base (P=0.005, the philtrum length(P=0.013, and the angle (P=0.006. The CT measurements showed significant changes in thepyriform aperture (P<0.001 and the angle (P<0.001.Conclusions An alveolar bone graft not only fills the gap in the alveolar process but alsoaugments the nostril base after surgery. In this study, only an alveolar bone graft was performedto prevent bias from other procedures. Nostril base augmentation can be achieved byperforming alveolar bone grafts in children, in whom invasive methods are not advised.

Woojin Lee

2013-09-01

212

External apical root resorption in maxillary incisors in orthodontic patients: associated factors and radiographic evaluation  

Energy Technology Data Exchange (ETDEWEB)

This study was performed to evaluate the incidence and degree of external apical root resorption of maxillary incisors after orthodontic treatment and to evaluate particular associated factors related to external apical root resorption. The records and maxillary incisor periapical radiographs of 181 patients were investigated. Crown and root lengths were measured and compared on the pre- and post-treatment periapical radiographs. Crown length was measured from the center of the incisal edge to the midpoint of the cemento-enamel junction (CEJ). Root length was measured from the CEJ midpoint to the root apex. A correction factor for the enlargement difference was used to calculate root resorption. The periapical radiographs of 564 teeth showed that the average root resorption was 1.39{+-}1.27 (8.24{+-}7.22%) and 1.69{+-}1.14 mm (10.16{+-}6.78%) for the maxillary central and lateral incisors, respectively. The results showed that the dilacerated or pointed roots, maxillary premolar extraction cases, and treatment duration were highly significant factors for root resorption (p<0.001). Allergic condition was a significant factor at p<0.01. Age at the start of treatment, large overjet, and history of facial trauma were also factors significantly associated with root resorption (p<0.05). There was no statistically significant difference in root resorption among the factors of gender, overbite, tongue-thrusting habit, types of malocclusion, and types of bracket. These results suggested that orthodontic treatment should be carefully performed in pre-treatment extraction patients who have pointed or dilacerated roots and need long treatment duration.

Nanekrungsan, Kamonporn [Dept. of Dentistry, Overbrook Hospital, Chiang Rai (Thailand); Patanaporn, Virush; Janhom, Apirum; Korwanich, Narumanus [Dept. of Chiang Mai University, Chiang Mai (Thailand)

2012-09-15

213

External apical root resorption in maxillary incisors in orthodontic patients: associated factors and radiographic evaluation  

International Nuclear Information System (INIS)

This study was performed to evaluate the incidence and degree of external apical root resorption of maxillary incisors after orthodontic treatment and to evaluate particular associated factors related to external apical root resorption. The records and maxillary incisor periapical radiographs of 181 patients were investigated. Crown and root lengths were measured and compared on the pre- and post-treatment periapical radiographs. Crown length was measured from the center of the incisal edge to the midpoint of the cemento-enamel junction (CEJ). Root length was measured from the CEJ midpoint to the root apex. A correction factor for the enlargement difference was used to calculate root resorption. The periapical radiographs of 564 teeth showed that the average root resorption was 1.39±1.27 (8.24±7.22%) and 1.69±1.14 mm (10.16±6.78%) for the maxillary central and lateral incisors, respectively. The results showed that the dilacerated or pointed roots, maxillary premolar extraction cases, and treatment duration were highly significant factors for root resorption (p<0.001). Allergic condition was a significant factor at p<0.01. Age at the start of treatment, large overjet, and history of facial trauma were also factors significantly associated with root resorption (p<0.05). There was no statistically significant difference in root resorption among the factors of gender, overbite, tongue-thrusting habit, types of malocclusion, and types of bracket. These results suggestypes of bracket. These results suggested that orthodontic treatment should be carefully performed in pre-treatment extraction patients who have pointed or dilacerated roots and need long treatment duration.

214

Alveolar Soft Part Sarcoma: A Rare Diagnosis  

Science.gov (United States)

Alveolar soft-part sarcoma (ASPS) is an extremely rare disease arising from connective tissues with a propensity for recurrence and metastasis. Clinically, it can be confused with hemangioma or arterio-venous malformations. Thus, a high index of suspicion and histopathological examination are required to make a definitive diagnosis. We report a case of recurrent ASPS in a young female with multiple sites involvement without any features of metastasis who has been treated with excision of the symptomatic lesions followed by chemotherapy. PMID:23723507

Sarkar, Priyanka; Mukherjee, Subhabrata; Saha, Makhan Lal; Biswas, Rabi Sankar

2013-01-01

215

Decreased alveolar oxygen induces lung inflammation  

OpenAIRE

Molecular mechanisms of the inflammatory reaction in hypoxia-induced lung injury are not well defined. Therefore, effects of alveolar hypoxia were studied in rat lungs, exposing rats to 10% oxygen over periods of 1, 2, 4, 6, and 8 h. An increase in the number of macrophages in bronchoalveolar lavage fluid of hypoxic animals was shown between 1 and 8 h. Extravasation of albumin was enhanced after 1 h and remained increased throughout the study period. NF-kappaB-binding activity as well as mRNA...

Madjdpour, C.; Jewell, U. R.; Kneller, S.; Ziegler, U.; Schwendener, R.; Booy, C.; Kla?usli, L.; Pasch, T.; Schimmer, R. C.; Beck-schimmer, B.

2003-01-01

216

Ridge from Strings  

CERN Document Server

In the colour string picture with fusion and percolation it is shown that long range azimuthal-rapidity correlations (ridge) can arise from the superposition of many events with exchange of clusters of different number of strings and not from a single event. Relation of the ridge with the flow harmonics coefficients is derived. By direct Monte-Carlo simulations, in the technique previously used to calculate these coefficients, ridge correlations are calculated for AA, pA and pp collisions. The azimuthal anisotropy follows from the assumed quenching of the emitted particles in the strong colour fields inside string clusters. It is confirmed that in pp collisions the ridge structure only appears in rare events with abnormally high multiplicity. Comarison with the experimental data shows a good agreement. Also a good agreement is found for pPb collisions. For AA collisions a reasonable agreement is found for both near-side and away-side angular correlations although it worsens at intermediate angles.

Braun, M A; Vechernin, V V

2014-01-01

217

Anaesthetic management of bilateral alveolar proteinosis for bronchopulmonary lavage.  

OpenAIRE

The most hazardous manifestation of pulmonary alveolar proteinosis is progressive hypoxia for which bronchopulmonary lavage (BPL) is the single most effective treatment. Unfortunately this procedure under general anesthesia itself increases the risk of hypoxia due to the need for one lung ventilation. It was therefore considered interesting to report the successful anaesthetic management of a patient with pulmonary alveolar proteinosis for Bronchopulmonary lavage.

Dixit R; Chaudhari L; Mahashur A

1998-01-01

218

Treatment to pulmonary alveolar proteinosis with total bronchoalveolar lavage  

International Nuclear Information System (INIS)

The pulmonary alveolar proteinosis is a rare disease with variable course and characterized by the accumulation of surfactant in the alveoli. By the treatment it was used the alveolar lavage with good results. We present the experience accumulated in the Las Americas clinic of Medellin city with the treatment of three patients with diagnosis of pulmonary alveolar proteinosis by alveolar lavage. We realized seven lavages, two of them bilateral and sequential. We didn't 't have important complications and in all cases we got good clinical and physiological results. Two patients had relapsed six and seven months after the first lavage and they needed a second lavage. We conclude that the pulmonary lavage is a secure and effective procedure in the treatment of the pulmonary alveolar proteinosis and the modality of bilateral sequential lavage is a good alternative and less expensive

219

Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.  

Science.gov (United States)

Carbonic anhydrase II (CAII) plays an important role in carbon dioxide metabolism and intracellular pH regulation. In this study, we provide evidence that CAII is expressed in both type I (AECI) and type II (AECII) alveolar epithelial cells by RT-PCR and Western blotting in freshly isolated rat cells. These results were further confirmed by double immunostaining with CAII antibodies and AECI- or AECII-specific markers in freshly isolated alveolar epithelial cells and rat lung tissues. Inhibition of CAII by acetazolamide or methazolamide delayed the decrease in the intracellular pH observed during hypercapnia in cultured AECI, AECII, and AECI-like cells. In an isolated-perfused rat lung model, alveolar fluid reabsorption significantly decreased during high CO(2) exposure, which was not prevented by carbonic anhydrase inhibition. Thus, we provide evidence that CAII is expressed in rat alveolar epithelial cells and does not regulate lung alveolar fluid reabsorption during hypercapnia. PMID:17690328

Chen, Jiwang; Lecuona, Emilia; Briva, Arturo; Welch, Lynn C; Sznajder, Jacob I

2008-01-01

220

Soil nitrogen drives community-level phosphorus resorption in a co-limited system: evidence from a northern hardwood forest  

Science.gov (United States)

Fertilization studies in northeastern forests suggest that forest productivity may be co-limited by nitrogen and phosphorus. Foliar nutrient resorption is a crucial conservation mechanism for plants. Resorption controls litterfall nutrient concentration, and litterfall is the largest aboveground nutrient flux in this system. Previous studies have attempted to link the foliar resorption of P to soil P status with mixed results. We propose that in an N and P co-limited system, foliar resorption of P may be linked to N availability. Here we compare the foliar chemistry of six hardwood tree species to soil chemistry across 18 plots in 6 stands in Bartlett Experimental Forest, New Hampshire. Resorption efficiency was calculated by species as the percent difference between green and senesced leaves. We weighted the resorption efficiencies for dominant tree species in each plot by their litterfall mass to create a community-level estimate of resorption for each plot. Estimates of soil N content to 30 centimeters in the mineral soil were strongly correlated with community-level estimates of both P resorption efficiency (p=0.002) and proficiency (p=0.006). At the population level, this trend was observed in four of the six tree species sampled. Neither N nor P resorption was correlated with any of the soil P fractions we examined. If N availability drives biological P conservation, it would provide an important mechanism for the coupled cycling of N and P in co-limited systems.

See, C. R.; Yanai, R. D.

2013-12-01

221

Resorption Rate Tunable Bioceramic: Si, Zn-Modified Tricalcium Phosphate  

Energy Technology Data Exchange (ETDEWEB)

This dissertation is organized in an alternate format. Several manuscripts which have already been published or are to be submitted for publication have been included as separate chapters. Chapter 1 is a general introduction which describes the dissertation organization and introduces the human bone and ceramic materials as bone substitute. Chapter 2 is the background and literature review on dissolution behavior of calcium phosphate, and discussion of motivation for this research. Chapter 3 is a manuscript entitled ''Si,Zn-modified tricalcium phosphate: a phase composition and crystal structure study'', which was published in ''Key Engineering Materials'' [1]. Chapter 4 gives more crystal structure details by neutron powder diffraction, which identifies the position for Si and Zn substitution and explains the stabilization mechanism of the structure. A manuscript entitled ''Crystal structure analysis of Si, Zn-modified Tricalcium phosphate by Neutron Powder Diffraction'' will be submitted to Biomaterials [2]. Chapter 5 is a manuscript, entitled ''Dissolution behavior and cytotoxicity test of Si, Zn-modified tricalcium phosphate'', which is to be submitted to Biomaterials [3]. This paper discusses the additives effect on the dissolution behavior of TCP, and cytotoxicity test result is also included. Chapter 6 is the study of hydrolysis process of {alpha}-tricalcium phosphate in the simulated body fluid, and the phase development during drying process is discussed. A manuscript entitled ''Hydrolysis of {alpha}-tricalcium phosphate in simulated body fluid and phase transformation during drying process'' is to be submitted to Biomaterials [4]. Ozan Ugurlu is included as co-authors in these two papers due to his TEM contributions. Appendix A is the general introduction of the materials synthesis, crystal structure and preliminary dissolution result. A manuscript entitled ''Resorption rate tunable bioceramic: Si and Zn-modified tricalcium phosphate'' was published in Ceramic Engineering and Science Proceedings (the 29th International Conference on Advanced Ceramics and Composites - Advances in Bioceramics and Biocomposites) [5].

Xiang Wei

2006-08-09

222

Expression of RANKL mRNA during Root Resorption Induced by Orthodontic Tooth Movement in Rats  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Receptor activator for nuclear factor kappa B ligand (RANKL, which is alsocalled osteoclast differentiation factor, is an important regulatory factor in osteoclastmaturation. Knowledge of bone and cementum similarities and RANKL role in bone resorptionsuggests the possibility of a role for this protein in root resorption induced by orthodontictooth movement. The aim of this study is to examine the expression of RANKLmRNA during root resorption induced by orthodontic tooth movement in rats.Materials and Methods: In order to move maxillary right first molars mesially fixed Ni-Ticlosed coil springs (Dentaurum®-Germany were tightened to the teeth. Sample consistedof 20 male seven week old Wistar rats. For each animal, the contralateral tooth was usedas, an internal control. At day 21 the rats were sacrificed. Tissues from 10 rats were embeddedin paraffin for histologic examination. Scratched material from resorptive lacunaeon mesial sides of the roots of the other ten rats was used for extracting mRNA by RTPCR.Results: The histologic sections, analyzed histomorphometrically, showed a significantincrease in root resorption in the case group as compared to the control (p<0.001.Densitometric studies of RANKL mRNA expression band on gel electrophoresis showedsignificantly increased RANKL expression in the resorptive lacunae of the case group(p<0.001.Conclusion: This observation indicates increased RANKL

Massoud Seifi

2009-01-01

223

Endodontic Treatment in Submerged Roots: A Case Report  

OpenAIRE

Alveolar ridge resorption has long been considered an unavoidable consequence of tooth extraction. While the extent and pattern of resorption is variable among individuals, there is a progressive loss of ridge contour as a result of physiologic bone remodeling. Even today, with best modalities of tooth preservation, there is a group of elderly individuals who do not bene?t from modern preventive practices and who now present a dilemma in terms of maintaining the masticatory apparatus necess...

Pameshwar Hiremath, Hemalatha; S Doshi, Yogesh; Siddayya Kulkarni, Sadanand; Kumar Purbay, Saurav

2010-01-01

224

Vertical root fracture: preservation of the alveolar ridge using immediate implants.  

Science.gov (United States)

Teeth with vertical root fracture (VRF) have complete or incomplete fractures that begin in the root and extend toward the occlusal surface. The most frequent causes of VRF originate from physical trauma, occlusal prematurity, inadequate endodontic treatment, and iatrogenic causes. Diagnose is difficult and delay can cause stomatognathic system problem. The purpose of this case report was to evaluate immediate implant placement after extraction of teeth with vertical root fracture. For the 1st case, the VRF in 1st left lower molar was confirmed during surgical flap and at the same time, the tooth was removed and immediate implant was placed. For the 2nd case, the VRF 1st left lower molar was confirmed during endodontic access and at the same appointment, the tooth was removed and the immediate implant is placed. Several studies have shown that immediate implants have similar success rates when compared with late implants. Consider that this approach is a safe procedure with favorable prognosis. In cases of VRF, the main factor to be considered is the presence of adequate bone support and immediate implants can preserve the vertical bone height, adding the fact that good patient compliance reduces the number of surgical interventions and promotes the functionality of stomatognathic system. PMID:24715996

Oya, Edmar de Oliveira; Pallos, Debora; Schwartz-Filho, Humberto Osvaldo; Brandt, William Cunha; Sendyk, Wilson Roberto; Roman-Torres, Caio Vinicius Gonçalves

2014-01-01

225

Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Rationale Pulmonary Alveolar Proteinosis (PAP patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly reduced expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPAR? and the PPAR?-regulated ATP binding cassette (ABC lipid transporter, ABCG1. An open label proof of concept Phase II clinical trial was conducted in PAP patients using rituximab, a chimeric murine-human monoclonal antibody directed against B lymphocyte specific antigen CD20. Rituximab treatment decreased anti-GM-CSF antibody levels in bronchoalveolar lavage (BAL fluid, and 7/9 patients completing the trial demonstrated clinical improvement as measured by arterial blood oxygenation. Objectives This study sought to determine whether rituximab therapy would restore lipid metabolism in PAP alveolar macrophages. Methods BAL samples were collected from patients pre- and 6-months post-rituximab infusion for evaluation of mRNA and lipid changes. Results Mean PPAR? and ABCG1 mRNA expression increased 2.8 and 5.3-fold respectively (p???0.05 after treatment. Lysosomal phospholipase A2 (LPLA2 (a key enzyme in surfactant degradation mRNA expression was severely deficient in PAP patients pre-treatment but increased 2.8-fold post-treatment. In supplemental animal studies, LPLA2 deficiency was verified in GM-CSF KO mice but was not present in macrophage-specific PPAR? KO mice compared to wild-type controls. Oil Red O intensity of PAP alveolar macrophages decreased after treatment, indicating reduced intracellular lipid while extracellular free cholesterol increased in BAL fluid. Furthermore, total protein and Surfactant protein A were significantly decreased in the BAL fluid post therapy. Conclusions Reduction in GM-CSF autoantibodies by rituximab therapy improves alveolar macrophage lipid metabolism by increasing lipid transport and surfactant catabolism. Mechanisms may involve GM-CSF stimulation of alveolar macrophage ABCG1 and LPLA2 activities by distinct pathways.

Malur Anagha

2012-06-01

226

[Histomorphology and resorption of longtime-implanted cartilage chips conserved in merthiolat in rhinoplasty (author's transl)].  

Science.gov (United States)

A histological study is presented on 18 cartilage grafts, conserved in Merthiolat TM, which had been implanted for reconstruction of the caudal border of the nose for time periods of 1 month up to 11 years. These cartilage graft preparations were compared to non graft cartilage from patients died in an age of 37, 51 and 53 years respectively. Our findings show that cartilage grafts are eroded from the edge by resorption granulations of the host. Besides resorption one case showed purulent chondritis and another one osteoneogenesis. The extent of the erosion and the resorption rate seem to depend strongly on the original quality of the cartilage graft. This is possibly due to degenerative focuses which could be found in all of the natural cartilage preparations. After our opinion these focuses regarded like "loci minoris resistentiae". Therefore cartilage material to be used for rhinoplasty ought to be checked for such degenerative focuses. PMID:651496

Eitschberger, E; Gammert, C; Masing, H; Pesch, H J

1978-05-01

227

Distribution of dissolved water in magmatic glass records growth and resorption of bubbles  

Science.gov (United States)

Volcanic eruptions are driven by the growth of gas bubbles in magma. Bubbles grow when dissolved volatile species, principally water, diffuse through the silicate melt and exsolve at the bubble wall. On rapid cooling, the melt quenches to glass, preserving the spatial distribution of water concentration around the bubbles (now vesicles), offering a window into pre-eruptive conditions. We measure the water distribution around vesicles in experimentally-vesiculated samples, with high spatial resolution. We find that, contrary to expectation, water concentration increases towards vesicles, indicating that water is resorbed from bubbles during cooling; textural evidence suggests that resorption occurs largely before the melt solidifies. Speciation data indicate that the molecular water distribution records resorption, whilst the hydroxyl distribution records earlier decompressive growth. Our results challenge the emerging paradigm that resorption indicates fluctuating pressure conditions, and lay the foundations for a new tool for reconstructing the eruptive history of natural volcanic products.

McIntosh, I. M.; Llewellin, E. W.; Humphreys, M. C. S.; Nichols, A. R. L.; Burgisser, A.; Schipper, C. I.; Larsen, J. F.

2014-09-01

228

The ridge laboratory  

OpenAIRE

Mechanisms proposed to explain the jet-related correlation of long range in rapidity (the ridge) observed in high-energy heavy-ion collisions are reviewed. Limitations of a model using the combined effect of transverse flow and a direction bias of partons suffering energy loss are discussed. The influence of the time scale of the correlation mechanism on the rapidity range is investigated.

Peitzmann, T.

2009-01-01

229

Orthodontic treatment in patient with idiopathic root resorption: A case report  

Scientific Electronic Library Online (English)

Full Text Available A reabsorção radicular externa idiopática é uma rara condição patológica, normalmente detectada como um achado fortuito radiológico. Trata-se de um processo multifatorial, relacionado a diversos fatores locais e sistêmicos. Se um fator etiológico não for identificado, a reabsorção radicular é classi [...] ficada como idiopática. Apresentamos o caso de uma paciente do sexo feminino com reabsorção radicular idiopática, que procurou tratamento ortodôntico para corrigir uma má oclusão. Esse tipo de reabsorção começa apicalmente e evolui coronalmente, provocando o encurtamento gradual e o arredondamento da raiz remanescente. Os pacientes com essa condição não são os candidatos ideais para o tratamento ortodôntico, no entanto, o objetivo desse relato é descrever um caso incomum de reabsorção radicular idiopática que envolveu toda a dentição. Além disso, pretende-se apresentar o tratamento ortodôntico da paciente. Também são descritos o progresso e a conclusão do tratamento ortodôntico, assim como os satisfatórios resultados finais. Abstract in english Multiple idiopathic external root resorption is a rare pathological condition usually detected as an incidental radiographic finding. External root resorption of permanent teeth is a multifactorial process related to several local and systemic factors. If an etiological factor cannot be identified f [...] or root resorption, the term "idiopathic" is applied. This report presents a case of multiple idiopathic apical root resorption. The condition was found in a young female patient seeking orthodontic treatment due to malocclusion. This kind of resorption starts apically and progresses coronally, causing a gradual shortening and rounding of the remaining root. Patients with this condition are not the ideal candidates for orthodontic treatment; however, the aim of this report is to describe an unusual case of idiopathic root resorption involving the entire dentition, and to present the orthodontic treatment of this patient. It describes the progress and completion of orthodontic therapy with satisfactory end results.

Diego, Rey; Rosana Martínez, Smit; Liliana, Gamboa.

2015-02-01

230

Comparison between two tomographic sections in the diagnosis of external root resorption  

Scientific Electronic Library Online (English)

Full Text Available OBJECTIVES: To assess the accuracy of coronal and sagittal CT sections to detect cavities simulating root resorption. MATERIAL AND METHODS: 60 mandibular incisors were embedded in plaster bases, and cavities with 0.6, 1.2 or 1.8 mm in diameter and 0.3, 0.6 or 0.9 mm in depth (small, medium and large [...] cavities) were drilled on the buccal surfaces with high-speed round burs with diameters of 0.6, 1.2 and 1.8 mm to simulate external inflammatory root resorption. Simulations in the cervical, middle and apical thirds of each tooth root were made randomly. The Dental Scan software was used to obtain 1-mm-thick axial images from direct scanning, which were reconstructed in the coronal and sagittal planes using 3D software (Syngo FastView). Each series was loaded into the software. Fourteen images of each tooth were reconstructed in the coronal plane and 14 in the sagittal plane. A total of 1,652 images were obtained for analysis. Series information, tooth number and the plane reconstructed were stored. The images generated were saved on a CD-ROM together with the visualization software (Syngo FastView). Images were analyzed by a previously calibrated blinded, radiologist. Cochran's Q test was conducted separately for each region analyzed followed by pair-wise comparison by the McNemar test (p=0.05). RESULTS: No statistically significant difference (p>0.05) was observed in the diagnosis of simulated resorption between the apical, middle, and coronal thirds. When the axial plane was assessed separately, diagnoses were statistically different (p0.05) between planes, irrespective of the third in which the resorptions were located. CONCLUSION: When tomographic sections are requested for the diagnosis of buccal or lingual external root resorption, sagittal sections afford the best image characterization of the resorption process.

Cláudio Afonso, Lermen; Gabriela Salatino, Liedke; Heloísa Emília Dias da, Silveira; Heraldo Luis Dias da, Silveira; Alessandro André, Mazzola; José Antônio Poli de, Figueiredo.

2010-06-01

231

Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.  

Science.gov (United States)

Mycobacterium tuberculosis invades alveolar epithelial cells as well as macrophages. However, the role of alveolar epithelial cells in the host defense against M. tuberculosis remains unknown. In this study, we report that lipocalin 2 (Lcn2)-dependent inhibition of mycobacterial growth within epithelial cells is required for anti-mycobacterial innate immune responses. Lcn2 is secreted into the alveolar space by alveolar macrophages and epithelial cells during the early phase of respiratory mycobacterial infection. Lcn2 inhibits the in vitro growth of mycobacteria through sequestration of iron uptake. Lcn2-deficient mice are highly susceptible to intratracheal infection with M. tuberculosis. Histological analyses at the early phase of mycobacterial infection in Lcn2-deficient mice reveal increased numbers of mycobacteria in epithelial cell layers, but not in macrophages, in the lungs. Increased intracellular mycobacterial growth is observed in alveolar epithelial cells, but not in alveolar macrophages, from Lcn2-deficient mice. The inhibitory action of Lcn2 is blocked by the addition of endocytosis inhibitors, suggesting that internalization of Lcn2 into the epithelial cells is a prerequisite for the inhibition of intracellular mycobacterial growth. Taken together, these findings highlight a pivotal role for alveolar epithelial cells during mycobacterial infection, in which Lcn2 mediates anti-mycobacterial innate immune responses within the epithelial cells. PMID:19050270

Saiga, Hiroyuki; Nishimura, Junichi; Kuwata, Hirotaka; Okuyama, Megumi; Matsumoto, Sohkichi; Sato, Shintaro; Matsumoto, Makoto; Akira, Shizuo; Yoshikai, Yasunobu; Honda, Kenya; Yamamoto, Masahiro; Takeda, Kiyoshi

2008-12-15

232

Intracellular particle dissolution in alveolar macrophages.  

Science.gov (United States)

Aerosol particles deposited in the lungs that are not readily soluble in the epithelial lining fluid will be phagocytized by alveolar macrophages (AM). Inside the phagolysosomal vacuole, the constituents of the plasma allow dissolution of a variety of compounds at a higher rate than dissolution in extracellular lung fluids. Chelator concentration and a pH value of about 5 were found to control intracellular particle dissolution (IPD). Hence, IPD is the initial step of translocation of dissolved material to blood, which is an important lung clearance mechanism for particles retained long term. IPD rates of uniform test particles determined in human, baboon, and canine AM cultures were similar to initial translocation rates determined in lung clearance studies of the same species after inhalation of the same test particles. IPD rate in cultured AM proved to be a sensitive functional parameter of AM, which was used to identify changes in the clearance mechanism of translocation during different exposure conditions. PMID:1396446

Kreyling, W G

1992-07-01

233

Computed tomographic appearances of pulmonary alveolar proteinosis  

Energy Technology Data Exchange (ETDEWEB)

We evaluated longitudinal changes in chest CT images in six cases (5 males and one female, age: 35-57 yr) of pulmonary alveolar proteinosis treated with bronchopulmonary lavage. Chest CT images on admission showed a mixed pattern of air-space consolidation and reticular or reticulonodular shadows in most cases and showed a peripheral clear zone in all cases. These shadows gradually diminished after bronchopulmonary lavage. Some cases revealed early improvement in the hilar zone while others had equal improvement in all lung lesions. In one case, consolidation was changed into reticular shadows by treatment. Previous reports have indicated that 'interstitial shadows which disappeared with lavage' reflect edematous thickening of interlobular septa. However, our longitudinal evaluation suggests that interstitial shadows on CT images may reflect not only real interstitial infiltration but also inhomogeneous distribution of intralobular deposits. (author).

Takiguchi, Yasuo; Uchiyama, Takashi; Nagao, Keiichi; Kuriyama, Takayuki (Chiba Univ. (Japan). School of Medicine); Fujita, Akira; Hashizume, Ikko

1994-03-01

234

Diffuse alveolar hemorrhage due to ketorolac tromethamine.  

Science.gov (United States)

Drug-induced lung disease (DILD) is a common but frequently missed diagnosis. Therefore, a high index of clinical suspicion and familiarity with the clinical syndromes associated with DILD are important in making the diagnosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the mostly commonly used classes of medications. NSAIDs are safe when used at prescribed doses. Side effects from use of NSAIDs are not uncommon and can affect almost every organ system in the body. NSAIDs are notorious for causing pulmonary toxicity, the common ones being bronchospasm and hypersensitivity reactions. Diffuse alveolar hemorrhage (DAH) secondary to NSAIDs is uncommon. Here, we report a case of DAH secondary to the use of ketorolac tromethamine. PMID:23867384

Marak, Creticus P; Alappan, Narendrakumar; Shim, Chang; Guddati, Achuta K

2013-01-01

235

Histometric analysis of rat alveolar wound healing.  

Science.gov (United States)

The chronology of alveolar wound healing was analyzed by a standard stereological method (point-counting volumetry) in normal rats. The upper right incisors were extracted and the animals were killed 1, 2, 3 and 6 weeks postoperatively. A light camera was used to determine the volume fraction of histologic components in the apical, middle and cervical thirds of the alveolus. Progressive bone neoformation was quantified, in parallel to a decrease in percent volume of connective tissue. A significantly smaller volume fraction of bone trabeculae in the cervical third of the socket was observed at all periods except the 6th week. The present histometric data show that bone neoformation continued to proceed beyond the 3rd postoperative week. PMID:9485631

Carvalho, T L; Bombonato, K F; Brentegani, L G

1997-01-01

236

Butyrfentanyl overdose resulting in diffuse alveolar hemorrhage.  

Science.gov (United States)

Butyrfentanyl is a potent short-acting opioid and a fentanyl analog with uncertain clinical effects. A review of the literature reveals no human case reports of butyrfentanyl overdose. As the use of analog and synthetic drugs continues to increase, clinicians are often faced with tremendous uncertainty when they encounter patients exposed to these synthetic drugs. We describe, to our knowledge, the first case of a butyrfentanyl overdose that resulted in clinically significant hemoptysis, acute lung injury, hypoxic respiratory failure, and diffuse alveolar hemorrhage. Complicating this case was a false-positive urine drug screen for fentanyl. Clinicians who encounter fentanyl exposures should be aware they may in fact be dealing with butyrfentanyl. As little is known of butyrfentanyl and our patient suffered a significant pulmonary hemorrhage, those who encounter butyrfentanyl exposures should monitor for hemorrhagic complications. PMID:25713275

Cole, Jon B; Dunbar, John F; McIntire, Sarah A; Regelmann, Warren E; Slusher, Tina M

2015-03-01

237

The clinical study of the early soft tissue healing and marginal bone resorption after non-submerged implants  

International Nuclear Information System (INIS)

Objective: To compare the amount of early marginal bone resorption in the first three months after non-submerged implants and to explore the relationship between the amount of early marginal bone resorption and the soft tissue healing in the first month. Method: ITI with non-submerged implants were implanted in 33 patients. Digital panoramic radiographs were taken during the operation, one month and three months later. The amount of marginal bone resorption was measured in the first, second and the third month after implant operation. The soft tissue healing was observed after 10 days. Results: There was significant difference (P<0.01) in the amount of early marginal bone resorption between one month and three months later. The early marginal bone resorption in the first month after implantation kept correlation with the soft tissue healing on 10th day(r=0.794, P<0.01). Conclusion: The amount of early marginal bone resorption in the first month exceeds that in the second and the third months after implant operation, and the soft tissue healing affects the amount of early marginal bone resorption in the first month. Biological seal is the critical factor influencing the early marginal bone resorption. (authors)

238

Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption  

DEFF Research Database (Denmark)

Bone resorption is initiated by osteoclastic acidification of the resorption lacunae. This process is mediated by secretion of protons through the V-ATPase and chloride through the chloride antiporter ClC-7. To shed light on the intracellular signalling controlling extracellular acidification, we screened a protein kinase inhibitor library in human osteoclasts.

SØrensen, Mette G; Karsdal, Morten A

2010-01-01

239

Elevación del piso del seno maxilar a través de la cresta ósea alveolar, mediante el uso de osteotomos: Reporte de caso clínico  

Scientific Electronic Library Online (English)

Full Text Available SciELO Venezuela | Language: Spanish Abstract in spanish En el presente artículo se describe la técnica de aumento del piso del seno maxilar a través del reborde alveolar, mediante el uso de osteotomos en combinación con procedimientos de regeneración ósea guiada y uso de biomateriales de relleno. Se reporta el caso de una paciente femenina de 65 años de [...] edad, con disminución de altura ósea del reborde alveolar, debido a la neumatización de los senos maxilares, asociada con moderada reabsorción ósea, a quien se le colocó a nivel del primer molar superior izquierdo implantes 3,5 x 11 mm IMTEC Endure Internal Hex System y se aplicó la técnica descrita de aumento del piso del seno maxilar. Mediante esta técnica es posible la elevación atraumática de la membrana sinusal, con bajo riesgo de lesionarla. Abstract in english In the present article, the technique of maxillary sinus floor increase through the alveolar ridge by using osteotomes in combination with bone regeneration guided procedures and the use of biomaterial fillings is described. It is reported the case of a 65 year old, female patient, with a decrease o [...] f alveolar ridge bone height due to the pneumatization of the maxillary sinus, associated with moderate bone re-absorption. The procedure consisted on the placement of a 3.5 x 11 mm IMTEC Endure Internal Hex System implant, at the level of the superior left first molar and the application of the technique described before (maxillary sinus floor increase). By using this technique, an atraumatic elevation of the sinus membrane is possible with low risk of injuring it.

E, Di Natale.

2009-06-01

240

Bathymetry of the Reykjanes Ridge  

OpenAIRE

We present a series of 1:200,000 scale maps of the bathymetry of the Reykjanes Ridge. The data are divided into four maps, extending 630 km along the ridge axis and between 30 and 100 km off-axis. This compilation of bathymetry data is extremely detailed, gridded at approximately 100 m resolution, and with almost no gaps. The Reykjanes Ridge is one of the best examples of a hotspot-dominated ridge, whose characteristics are influenced by its proximity to the Iceland plume. Many fundamental qu...

Keeton, Ja; Searle, Rc; Parsons, B.; White, Rs; Murton, Bj; Parson, Lm; Peirce, C.; Sinha, Mc

1997-01-01

241

Inferior alveolar nerve sensitivity changes after mandibular trauma  

Directory of Open Access Journals (Sweden)

Full Text Available The investigation was performed on 195 patients, who had fracture on mandibular angle zone. In control group pain thresholds of infraorbital nerve and inferior alveolar nerve did not differ significantly (p > 0.05. Consequently, lesion degree of inferior alveolar nerve and its functional recovery dynamics were estimated objectively according to pain threshold and lesion index of neural function. Stump dislocation extent has influence on neural lesion: the more expressed dislocation, the higher likelihood of severe lesion of inferior alveolar nerve. Three degrees of neural lesion were identified in the case of mandibular angle fracture. When minor lesion of inferior alveolar nerve took place (17.4%, sensation recovered in 21 days after stump reposition and fixation; moderate lesion of nerve (55.8% had sensory recovery after 28 days, and in the case of severe lesion of nerve (26.6% neural function did not recover even after 90 days.

Simonas Grybauskas

2010-12-01

242

Primary cerebral alveolar echinococcosis: mycology to the rescue.  

Science.gov (United States)

A case of primary cerebral alveolar echinococcosis with a favorable outcome is reported. A universal fungal PCR enabled this diagnosis, while the initial serological analysis remained noncontributive. PMID:24478516

Debourgogne, Anne; Goehringer, François; Umhang, Gérald; Gauchotte, Guillaume; Hénard, Sandrine; Boué, Franck; May, Thierry; Machouart, Marie

2014-02-01

243

Endothelin-1 Impairs Alveolar Epithelial Function via Endothelial ETB Receptor  

OpenAIRE

Rationale: Endothelin-1 (ET-1) is increased in patients with high-altitude pulmonary edema and acute respiratory distress syndrome, and these patients have decreased alveolar fluid reabsorption (AFR).

Comellas, Alejandro P.; Briva, Arturo; Dada, Laura A.; Butti, Maria L.; Trejo, Humberto E.; Yshii, Cecilia; Azzam, Zaher S.; Litvan, Juan; Chen, Jiwang; Lecuona, Emilia; Pesce, Liuska M.; Yanagisawa, Masashi; Sznajder, Jacob I.

2008-01-01

244

Diffuse alveolar hemorrhage as a manifestation of Behçet disease  

Directory of Open Access Journals (Sweden)

Full Text Available Diffuse alveolar hemorrhage (DAH is a rare life-threatening condition which refers to the presence of red blood cells within alveoli deriving from hemorrhage originating in the pulmonary microvasculature. It differs from alveolar filling, in which blood cells derive from localized bleeding, usually of bronchial origin. DAH may be part of diffuse alveolar injury of any origin. DAH should be considered a medical emergency due to the significant morbidity and mortality associated with respiratory failure, when secondary to impaired oxygen uptake from alveoli filled with erythrocytes. Patients with alveolar hemorrhage present with non-specific symptoms like dyspnea, cough and hemoptysis, which is not always present. They may develop acutely or insidiously over a few days. We present a case of a patient with probable Behçet’s disease complicated by pulmonary capillaritis and DAH resulting in refractory respiratory failure and death.

V. Grosso

2013-07-01

245

[The interdisciplinary fixed restoration of an edentulous maxilla with a marked resorption of the alveolar crest. A case report. Part II: the definitive restoration].  

Science.gov (United States)

Different materials and methods can be used for edentulous maxillae rehabilitations. A precise fit between the implant and the framework is assumed. Hence, often implant suprastructures made by conventional lost wax techniques lack such a fit and a secondary modification is necessary. Alternatively the CNC-milling technique provides implant frameworks with a passive fit made of titanium and recently also of zirconia. This article describes the fabrication of a fixed complete dental prosthesis supported by seven implants in an edentulous maxilla. Two prostheses were fabricated, one made of a titanium framework veneered with resin and one made experimentally of a zirconia framework veneered with ceramics. The clinical and technical steps are documented and discussed. PMID:19579837

Teubner, Eckart; Pietrobon, Nic; Lorenzon, Andreas; Marinello, Carlo P

2009-01-01

246

Combined effects of nitrogen addition and litter manipulation on nutrient resorption of Leymus chinensis in a semi-arid grassland of northern China.  

Science.gov (United States)

Plant growth in semi-arid ecosystems is usually severely limited by soil nutrient availability. Alleviation of these resource stresses by fertiliser application and aboveground litter input may affect plant internal nutrient cycling in such regions. We conducted a 4-year field experiment to investigate the effects of nitrogen (N) addition (10 g N·m(-2) ·year(-1)) and plant litter manipulation on nutrient resorption of Leymus chinensis, the dominant native grass in a semi-arid grassland in northern China. Although N addition had no clear effects on N and phosphorus (P) resorption efficiencies in leaves and culms, N fertilisation generally decreased leaf N resorption proficiency by 54%, culm N resorption proficiency by 65%. Moreover, N fertilisation increased leaf P resorption proficiency by 13%, culm P resorption proficiency by 20%. Under ambient or enriched N conditions, litter addition reduced N and P resorption proficiencies in both leaves and culms. The response of P resorption proficiency to litter manipulation was more sensitive than N resorption proficiency: P resorption proficiency in leaves and culms decreased strongly with increasing litter amount under both ambient and enriched N conditions. In contrast, N resorption proficiency was not significantly affected by litter addition, except for leaf N resorption proficiency under ambient N conditions. Furthermore, although litter addition caused a general decrease of leaf and culm nutrient resorption efficiencies under both ambient and enriched N conditions, litter addition effects on nutrient resorption efficiency were much weaker than the effects of litter addition on nutrient resorption proficiency. Taken together, our results show that leaf and non-leaf organs of L. chinensis respond consistently to altered soil N availability. Our study confirms the strong effects of N addition on plant nutrient resorption processes and the potential role of aboveground litter, the most important natural fertiliser in terrestrial ecosystems, in influencing plant internal nutrient cycling. PMID:24666511

Li, X; Liu, J; Fan, J; Ma, Y; Ding, S; Zhong, Z; Wang, D

2015-01-01

247

Osteoclast resorption of beta-tricalcium phosphate controlled by surface architecture.  

Science.gov (United States)

A resorbable bone graft substitute should mimic native bone in its capacity to support bone formation and be remodeled by osteoclasts (OCl) or other multinucleated cells such as foreign body giant cells (FBGC). We hypothesize that by changing the scale of surface architecture of beta-tricalcium phosphate (TCP), cellular resorption can be influenced. CD14(+) monocyte precursors were isolated from human peripheral blood (n = 4 independent donors) and differentiated into OCl or FBGC on the surface of TCP discs comprising either submicron- or micron-scale surface topographical features (TCPs and TCPb, respectively). On submicrostructured TCPs, OCl survived, fused, differentiated, and extensively resorbed the substrate; however, on microstructured TCPb, OCl survival, TRAP activation, and fusion were attenuated. Importantly, no resorption was observed on microstructured TCPb. By confocal microscopy, OCl formed on TCPs contained numerous actin rings allowing for resorption, but not on TCPb. In comparison, FBGC could not resorb either TCP material, suggesting that osteoclast-specific machinery is necessary to resorb TCP. By tuning surface architecture, it appears possible to control osteoclast resorption of calcium phosphate. This approach presents a useful strategy in the design of resorbable bone graft substitutes. PMID:24927681

Davison, Noel L; ten Harkel, Bas; Schoenmaker, Ton; Luo, Xiaoman; Yuan, Huipin; Everts, Vincent; Barrère-de Groot, Florence; de Bruijn, Joost D

2014-08-01

248

Identifying enamel diffusion properties in feline teeth affected with resorptive lesions  

Directory of Open Access Journals (Sweden)

Full Text Available Various factors have been suggested in the pathogenesis of feline resorptive lesions, such as periodontal disease, dietary factors, mechanical stress, developmental tooth defects, breed and viral disease, although none of these factors have been definitively proven to be the direct cause. It was recently published that normally enamel in cats is significantly thinner at the cemento-enamel junction, and both enamel and dentine are significantly less mineralized than elsewhere on the tooth. However, it is still unclear what anatomical features of the tooth surface are associated with a predisposition for resorptive lesions, and what is the initiating cause for the clastic activity afterwards. The present study was undertaken with the aim to describe enamel properties of transport and distribution of organic molecules in intact feline teeth and teeth affected with resorptive lesions. The results indicate that damaged enamel is prone to a greater bilateral diffusion process, leading to continuous disruption of the enamel structure. Also, teeth that are subjected to occlusal stress are at greater risk of destruction because micro fractures produce disarrangements in feline dental tissue diffusion homeostasis. The relationship between these features with feline dental resorptive lesions requires further studies.

Živkovi? R.

2011-01-01

249

Osteoclastic resorptive capacity is suppressed in patients receiving hyperbaric oxygen therapy.  

Science.gov (United States)

Background and purpose - Hypoxia, necrosis, and bone loss are hallmarks of many skeletal diseases. Hyperbaric oxygen therapy (HBO) is often used as an adjunctive therapy in these cases. However the in vivo effect of HBO on osteoclast formation has not been fully established. We therefore carried out a longitudinal study to examine the effect of HBO on osteoclast formation and bone resorptive capacity in patients who were referred to the Plymouth Hyperbaric Medical Centre. Methods - Osteoclast precursors were isolated from peripheral blood prior to and following 10 and 25 daily hyperbaric treatments (100% O2 at 2.4 atmospheres absolute ATA for 90 min) to determine osteoclast formation and resorptive capacity. The expression of key regulators of osteoclast differentiation RANK, Dc-STAMP, and NFATc1 was also assessed by quantitative real-time PCR. Results - HBO reduced the ability of precursors to form osteoclasts and reduced bone resorption in a treatment-dependent manner. The initial suppressive effect of HBO was more pronounced on mononuclear osteoclast formation than on multinuclear osteoclast formation, and this was accompanied by reduction in the expression of key regulators of osteoclast formation, RANK and Dc-STAMP. Interpretation - This study shows for the first time that in vivo, HBO suppresses the ability of monocytic precursors to form resorptive osteoclasts. PMID:25238438

Hadi, Hadil Al; Smerdon, Gary; W Fox, Simon

2015-04-01

250

Immunohistochemical expression of biglycan and decorin in the pulp tissue of human primary teeth during resorption  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in english Primary teeth are interesting models that can be used to study physiological and pathological processes involving cells and extracellular matrices in hard and soft tissues. This study investigated the expression and distribution of biglycan and decorin-the non-collagenous components of the extracell [...] ular matrix-in primary teeth tissue, during physiological root resorption. Thirty healthy human primary teeth were grouped together according to root length: Group I - two-thirds root length, Group II - one-third root length, and Group III - teeth with no root. The streptavidin-biotin-peroxidase immunohistochemical method was used with antibodies against the previously named antigens. The proteoglycans studied were found in the pulp and dentin extracellular matrix in all groups without any differences in the proteins, among the groups. Biglycan was observed mainly in predentin and in pulp connective tissue in the resorption area. In addition, decorin was observed mainly in pulp connective tissue, but near the resorption area. Biglycan and decorin were distributed differentially in the dental tissues. The present immunohistocytochemical data, combined with previously reported data, suggest that these proteoglycans could be involved in regulating the physiological resorption process in healthy primary teeth.

Monique Saveriano De, Benedetto; Filipe Modolo, Siqueira; Marcelo Betti, Mascaro; Vera Cavalcanti, Araujo; Marcelo Jose Strazzeri, Bonecker.

2013-09-01

251

An experimental study on the tooth root resorption for digital radiography  

International Nuclear Information System (INIS)

The purpose of this study was to quantitatively evaluated experimental tooth root resorption for digital radiography. For this study, experimentally three root sites were used, and radiograms were taken with standardized apparatus. Digital imaging system were consisted of NEC PC-9801 (computer), TRINITRON (monitor), SONY XC-711 CCD camera. The display monitor had a resolution of 512 X 512 pixels. The following results were obtained: 1. In the difference of the four X-ray film of the contrast correction, the contrast difference was one gray scale variation at mean value. 2. Viewing of the view box of the periapical radiographs, experimental tooth root resorption of the periapical area of the first premolar, middle of mesial surface of the first molar mesial root, middle of lingual surface of the first molar distal root were recognized by increased diameter. 3. On the analysis by histogram, the periapical area of the first premolar, the middle surface of the first molar mesial root were each recognized tooth root resorption of the 5,6,7 pixel, 2,4,5 pixel by increased diameter. 4. On the analysis by histogram, the middle of lingual surface of the first molar distal root was each recognized tooth root resorption of the none, 3,6, pixel by increased diameter.

252

Hypoxia induces giant osteoclast formation and extensive bone resorption in the cat.  

Science.gov (United States)

Dental disease due to osteoclast (OC) overactivity reaches epidemic proportions in older domestic cats and has also been reported in wild cats. Feline odontoclastic resorptive lesions (FORL) involve extensive resorption of the tooth, leaving it liable to root fracture and subsequent loss. The etiopathogenesis of FORL remains unclear. Here, we explore the hypothesis that FORL is associated with hypoxia in the oral microenvironment, leading to increased OC activity. To investigate this, we developed a method of generating OCs from cat blood. Reducing O2 from 20% to 2% increased the mean area of OC eightfold from 0.01 to 0.08 mm2. In hypoxic cultures, very large OCs containing several hundred nuclei were evident (reaching a maximum size of approximately 14 mm2). Cultures exposed to 2% O2 exhibited an increase of approximately 13-fold in the area of bone slices covered by resorption lacunae. In line with this finding, there was a significant increase in cells differentiating under hypoxic conditions, reflected in increased expression of cathepsin K and proton pump enzymes. In conclusion, these results demonstrate that oxygen tension is a major regulator of OC formation in the cat. However, in this species, hypoxia induces the formation of "giant" OCs, which can be so large as to be visible with the naked eye and yet also actively resorb. This suggests that local hypoxia is likely to play a key role in the pathogenesis of FORL and other inflammatory conditions that are associated with bone resorption in cats. PMID:17048066

Muzylak, M; Price, J S; Horton, M A

2006-11-01

253

Update on diffuse alveolar hemorrhage and pulmonary vasculitis.  

Science.gov (United States)

Diffuse alveolar hemorrhage is a clinical syndrome that can be a manifestation of multiple different causes. Identification of the underlying etiology is of utmost importance and dictates treatment. Pulmonary vasculitis including antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a common cause of diffuse alveolar hemorrhage. For AAV, treatment includes induction followed by maintenance therapy. Rituximab has an increasing role in the treatment of AAV. PMID:23102067

Krause, Megan L; Cartin-Ceba, Rodrigo; Specks, Ulrich; Peikert, Tobias

2012-11-01

254

Noninvasive assessment of alveolar microvascular recruitment in conscious nonsedated rats  

OpenAIRE

Recruitment of alveolar microvascular reserves, assessed from the relationship between pulmonary diffusing capacity (DLCO) and perfusion (Q?c), is critical to maintenance of arterial blood oxygenation. Leptin-resistant ZDF fatty diabetic (fa/fa) rats exhibit restricted cardiopulmonary physiology under anesthesia. To assess alveolar microvascular function in conscious, non-sedated, non-instrumented, and minimally restrained animals, we adapted a rebreathing technique to fa/fa and control non-...

Yilmaz, Cuneyt; Dane, Dan M.; Ravikumar, Priya; Unger, Roger H.; Hsia, Connie C. W.

2013-01-01

255

A basic review on the inferior alveolar nerve block techniques  

OpenAIRE

The inferior alveolar nerve block is the most common injection technique used in dentistry and many modifications of the conventional nerve block have been recently described in the literature. Selecting the best technique by the dentist or surgeon depends on many factors including the success rate and complications related to the selected technique. Dentists should be aware of the available current modifications of the inferior alveolar nerve block techniques in order to effectively choose b...

Khalil, Hesham

2014-01-01

256

Inferior alveolar nerve sensitivity changes after mandibular trauma  

OpenAIRE

The investigation was performed on 195 patients, who had fracture on mandibular angle zone. In control group pain thresholds of infraorbital nerve and inferior alveolar nerve did not differ significantly (p > 0.05). Consequently, lesion degree of inferior alveolar nerve and its functional recovery dynamics were estimated objectively according to pain threshold and lesion index of neural function. Stump dislocation extent has influence on neural lesion: the more expressed dislocation, the high...

Simonas Grybauskas; Algirdas Lukosiunas; Gintautas Sabalys; Ricardas Kubilius; Dainius Razukevicius

2010-01-01

257

Arched Needle Technique for Inferior Alveolar Mandibular Nerve Block  

OpenAIRE

One of the most commonly used local anesthetic techniques in dentistry is the Fischer’s technique for the inferior alveolar nerve block. Incidentally this technique also suffers the maximum failure rate of approximately 35–45%. We studied a method of inferior alveolar nerve block by injecting a local anesthetic solution into the pterygomandibular space by arching and changing the approach angle of the conventional technique and estimated its efficacy. The needle after the initial insertio...

Chakranarayan, Ashish; Mukherjee, B.

2011-01-01

258

Orbital alveolar soft part sarcoma: Histopathologic report of two cases  

Science.gov (United States)

Alveolar soft part sarcoma is considered as a distinct histopathological entity with rare cases reported from the orbit area. Two cases of alveolar soft part sarcomas occurring in the orbit of two patients along with their histopathologic findings are reported herewith. In both cases, the patients presented with eyelid swelling and proptosis. The diagnosis was made by incisional biopsies and histopathology. The literature is reviewed regarding occurrence of this tumor, its diagnosis and management. PMID:23960876

Alkatan, Hind; Al-Shedoukhy, Ahlam A.; Chaudhry, Imtiaz A.; Al-Ayoubi, Ayman

2010-01-01

259

PDGFR? reverses EphB4 signaling in alveolar rhabdomyosarcoma  

OpenAIRE

Effective targeted therapies to complement already intensive chemotherapy are much needed for the childhood muscle cancer rhabdomyosarcoma, yet few targeted agents have been identified that improve long-term survival. In particular, the alveolar subtype of rhabdomyosarcoma accounts for disproportionate mortality. Herein, the receptor tyrosine kinase EphB4 is identified as a potential two-way switch for alveolar rhabdomyosarcoma. Whereas the typical EphB4 ligand, EphrinB2, drives tumor cells t...

Aslam, M. Imran; Abraham, Jinu; Mansoor, Atiya; Druker, Brian J.; Tyner, Jeffrey W.; Keller, Charles

2014-01-01

260

Carbonic Anhydrase II and Alveolar Fluid Reabsorption during Hypercapnia  

OpenAIRE

Carbonic anhydrase II (CAII) plays an important role in carbon dioxide metabolism and intracellular pH regulation. In this study, we provide evidence that CAII is expressed in both type I (AECI) and type II (AECII) alveolar epithelial cells by RT-PCR and Western blotting in freshly isolated rat cells. These results were further confirmed by double immunostaining with CAII antibodies and AECI- or AECII-specific markers in freshly isolated alveolar epithelial cells and rat lung tissues. Inhibit...

Chen, Jiwang; Lecuona, Emilia; Briva, Arturo; Welch, Lynn C.; Sznajder, Jacob I.

2007-01-01

261

A 55 years old man with pulmonary alveolar microlithiasis  

OpenAIRE

Pulmonary alveolar microlithiasis (PAM) is a very rare diffuse chronic lung disease characterized by deposition of small spherules of calcium phosphate within the alveolar cavity. The disease is usually seen from birth up to 40 years of age and is usually diagnosed incidentally during radiography of the chest for other reasons. Most of patients are asymptomatic or having very mild symptoms and the majority of patients either have normal or restrictive pulmonary function test. Clinically, the ...

Saeed, Rebeen R.; Ali, Kosar M.

2014-01-01

262

Dynamic thermal performance of alveolar brick construction system  

Energy Technology Data Exchange (ETDEWEB)

Highlights: {yields} Even though U-value does not measure thermal inertia, it is the commonly used parameter. {yields} The thermal performance analysis of buildings must include the evaluation of transient parameters. {yields} Transient parameters of alveolar brick constructive system show good agreement with its low energy consumption. -- Abstract: Alveolar bricks are being introduced in building sector due to the simplicity of their construction system and to the elimination of the insulation material. Nevertheless, it is not clear if this new system is energetically efficient and which is its thermal behaviour. This paper presents an experimental and theoretical study to evaluate the thermal behaviour of the alveolar brick construction system, compared with a traditional Mediterranean brick system with insulation. The experimental study consists of measuring the thermal performance of four real house-like cubicles. The thermal transmittance in steady-state, also known as U-value, is calculated theoretically and experimentally for each cubicle, presenting the insulated cubicles as the best construction system, with differences around 45% in comparison to the alveolar one. On the other hand, experimental results show significantly smaller differences on the energy consumption between the alveolar and insulated construction systems during summer period (around 13% higher for the alveolar cubicle). These values demonstrate the high thermal efficiency of the alveolar system. In addition, the lack of agreement between the measured energy consumption and the calculated U-values, guides the authors to analyze the thermal inertia of the different building components. Therefore, several transient parameters, extracted from the heat transfer matrix and from experimental data, are also evaluated. It can be concluded that the alveolar brick construction system presents higher thermal inertia than the insulated one, justifying the low measured energy consumption.

Gracia, A. de; Castell, A.; Medrano, M. [GREA Innovacio Concurrent, Edifici CREA, Universitat de Lleida, Pere de Cabrera s/n, 25001 Lleida (Spain); Cabeza, L.F., E-mail: lcabeza@diei.udl.ca [GREA Innovacio Concurrent, Edifici CREA, Universitat de Lleida, Pere de Cabrera s/n, 25001 Lleida (Spain)

2011-07-15

263

Diffuse alveolar hemorrhage in Wegener?s granulomatosis  

Directory of Open Access Journals (Sweden)

Full Text Available Diffuse alveolar hemorrhage is a life-threatening though rare manifestation of Wegener?s granulomatosis (WG. An active diagnostic workup, intensive observation, and aggressive immunosuppressive treatment are cornerstones of the management. The treatment modalities available for such complications are pulse cyclophosphamide therapy with steroids. We report here a case of WG with diffuse alveolar hemorrhage as the first manifestation of the disease in life that responded to steroids and cyclophosphamide.

Mahajan Vineet

2011-01-01

264

Diffuse alveolar hemorrhage in Wegener’s granulomatosis  

OpenAIRE

Diffuse alveolar hemorrhage is a life-threatening though rare manifestation of Wegener’s granulomatosis (WG). An active diagnostic workup, intensive observation, and aggressive immunosuppressive treatment are cornerstones of the management. The treatment modalities available for such complications are pulse cyclophosphamide therapy with steroids. We report here a case of WG with diffuse alveolar hemorrhage as the first manifestation of the disease in life that responded to steroids and cycl...

Mahajan, Vineet; Whig, Jagdeep; Kashyap, Anil; Gupta, Sushil

2011-01-01

265

Diffuse alveolar hemorrhage in Wegener?s granulomatosis  

OpenAIRE

Diffuse alveolar hemorrhage is a life-threatening though rare manifestation of Wegener?s granulomatosis (WG). An active diagnostic workup, intensive observation, and aggressive immunosuppressive treatment are cornerstones of the management. The treatment modalities available for such complications are pulse cyclophosphamide therapy with steroids. We report here a case of WG with diffuse alveolar hemorrhage as the first manifestation of the disease in life that responded to steroids and...

Mahajan Vineet; Whig Jagdeep; Kashyap Anil; Gupta Sushil

2011-01-01

266

Orbital alveolar soft part sarcoma: Histopathologic report of two cases  

OpenAIRE

Alveolar soft part sarcoma is considered as a distinct histopathological entity with rare cases reported from the orbit area. Two cases of alveolar soft part sarcomas occurring in the orbit of two patients along with their histopathologic findings are reported herewith. In both cases, the patients presented with eyelid swelling and proptosis. The diagnosis was made by incisional biopsies and histopathology. The literature is reviewed regarding occurrence of this tumor, its diagnosis and manag...

Alkatan, Hind; Al-shedoukhy, Ahlam A.; Chaudhry, Imtiaz A.; Al-ayoubi, Ayman

2010-01-01

267

Local strain distribution in real three-dimensional alveolar geometries.  

Science.gov (United States)

Mechanical ventilation is not only a life saving treatment but can also cause negative side effects. One of the main complications is inflammation caused by overstretching of the alveolar tissue. Previously, studies investigated either global strains or looked into which states lead to inflammatory reactions in cell cultures. However, the connection between the global deformation, of a tissue strip or the whole organ, and the strains reaching the single cells lining the alveolar walls is unknown and respective studies are still missing. The main reason for this is most likely the complex, sponge-like alveolar geometry, whose three-dimensional details have been unknown until recently. Utilizing synchrotron-based X-ray tomographic microscopy, we were able to generate real and detailed three-dimensional alveolar geometries on which we have performed finite-element simulations. This allowed us to determine, for the first time, a three-dimensional strain state within the alveolar wall. Briefly, precision-cut lung slices, prepared from isolated rat lungs, were scanned and segmented to provide a three-dimensional geometry. This was then discretized using newly developed tetrahedral elements. The main conclusions of this study are that the local strain in the alveolar wall can reach a multiple of the value of the global strain, for our simulations up to four times as high and that thin structures obviously cause hotspots that are especially at risk of overstretching. PMID:21607757

Rausch, S M K; Haberthür, D; Stampanoni, M; Schittny, J C; Wall, W A

2011-11-01

268

Human and feline invasive cervical resorptions: the missing link?--Presentation of four cases.  

Science.gov (United States)

This report describes 4 patients presenting with multiple teeth affected by invasive cervical resorption (ICR). The cases came to our attention between 2006 and 2008; previously, no cases of multiple ICR (mICR) had been reported in Switzerland. Characteristics common to all 4 cases included progression of disease over time, similar clinical and radiographic appearance of lesions, and obscure etiology. The histologically assessed teeth showed a similar pattern of tooth destruction, with resorptive lesions being confined to the cervical region. Howship's lacunae and multinucleated, tartrate-resistant acid phosphatase-positive odontoclasts were detected. None of the teeth presented with internal resorption. The positive pulp sensitivity corresponded to the histologic findings, indicating that the pulp tissue resisted degradation even in advanced stages of resorptive lesions. Although mICR is rare in humans, a similar disease known as feline odontoclastic resorptive lesions (FORL) is common in domestic, captive, and wild cats. The etiology of FORL, like that of mICR, remains largely unknown. Because FORL has been associated with feline viruses, we asked our mICR patients whether they had had contact with cats, and interestingly, all patients reported having had direct (2 cases) or indirect (2 cases) contact. In addition, blood samples were taken from all patients for neutralization testing of feline herpes virus type 1 (FeHV-1). Indeed, the sera obtained were able to neutralize (2 cases) or partly inhibit (2 cases) replication of FeHV-1, indicating transmission of feline viruses to humans. Future studies on mICR (and FORL) should evaluate the possible role of a (feline) virus as an etiologic (co-)factor in this disease. PMID:19482196

von Arx, Thomas; Schawalder, Peter; Ackermann, Mathias; Bosshardt, Dieter D

2009-06-01

269

Effect of alterations in the cyclopentane ring on bone resorptive activity of prostaglandin  

International Nuclear Information System (INIS)

Previous studies have shown that the natural prostanoids, PGE2, PGE1 and PGF2 alpha are potent stimulators of bone resorption. In this study, we have examined the effects of alterations in the cyclopentane ring of these prostanoids for their effect on the resorptive response of cultured long bones from 19-day fetal rats as measured by the release of previously incorporated 45Ca. Indomethacin (10(-6)M) was added to minimize endogenous prostaglandin production. In this system PGE2 and PGE1, the 9 keto, 11 alpha hydroxy compounds, were approximately equally effective at concentrations of 10(-8) to 10(-6) M. The 9 alpha hydroxy, 11 alpha hydroxy compound, PGF2 alpha, was active at 10(-7) to 10(-5) M. In contrast, the 9 alpha hydroxy, 11-keto compound, PGD2, showed only a minimal stimulation of bone resorption at 10(-5) M. While these data suggested that the 11 alpha hydroxy group was important for bone resorbing activity, 11 beta PGE2 and 11-deoxy PGE1 were only slightly less potent than their physiologic counterparts. Both 9 beta, 11 alpha PGF2 and 9 alpha, 11 beta PGF2 were less potent than PGF2 alpha but did cause substantial stimulation of bone resorption and were equally effective at 10(-6) to 10(-5) M. 9 alpha, 11 beta PGF2 alpha is of particular interest since it is major metabolite of PGD2. These results suggest that the binding of prostanoids to the receptor which mediates bone resorption is affected by changes at the 9 and 11 positions of the pentane at the 9 and 11 positions of the pentane ring but do not support the hypothesis that the 11 alpha OH function is essential for this biological activity

270

Lack of Interleukin 1-beta Expression Following Orthodontic Induced Root Resorption  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To determine the effect of orthodontic tooth movement on the expression ofinterleukin-1? mRNA in rats using RT-PCR.Materials and Methods: Sample consisted of eighteen 8-week-old male Wistar rats. Theright maxillary first molar of each animal was protracted using an orthodontic protraction appliance.The left maxillary first molar received no treatment and was assigned as the controlgroup. On day 21, all rats were sacrifice and divided in two equal groups. The first group,group (A, was histologically evaluated for the presence and size of potential resorptive lacunae.The second group, group (B, was investigated using RT-PCR in order to determineIL-1? mRNA expression.Results: Measurements revealed that the mean tooth movement was 0.23 mm in group Aand 0.24 mm in group B. The mean depth of the resorptive lacunae was 0.17×10-11 mm2 inthe control group and 4.9×10-11 mm2 in the intervention group (control group: left maxillaryfirst molars; right maxillary first molars were divided to group A & B, histologic study of groupA assures the existence of resorptive lacunae and its extent relative to control group. Thedifference between the two groups was statistically significant (p<0.05. The RT-PCR evaluationshowed no significant differences in IL-1? mRNA expressions of resorptive lacunaebetween the treated and untreated groups.Conclusion: Although interleukin1-beta is the most potent stimulator of bone resorptionand mediator of inflammatory response, the present study showed that the IL-1beta mRNAwas not expressed more significantly in root resorption lacunae of the treated molars relativeto the control group.

Massoud Seifi

2011-01-01

271

Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome.  

Science.gov (United States)

Acute respiratory distress syndrome (ARDS) is acute lung failure secondary to severe systemic inflammation, resulting in a derangement of alveolar mechanics (i.e. the dynamic change in alveolar size and shape during tidal ventilation), leading to alveolar instability that can cause further damage to the pulmonary parenchyma. Mechanical ventilation is a mainstay in the treatment of ARDS, but may induce mechano-physical stresses on unstable alveoli, which can paradoxically propagate the cellular and molecular processes exacerbating ARDS pathology. This phenomenon is called ventilator induced lung injury (VILI), and plays a significant role in morbidity and mortality associated with ARDS. In order to identify optimal ventilation strategies to limit VILI and treat ARDS, it is necessary to understand the complex interplay between biological and physical mechanisms of VILI, first at the alveolar level, and then in aggregate at the whole-lung level. Since there is no current consensus about the underlying dynamics of alveolar mechanics, as an initial step we investigate the ventilatory dynamics of an alveolar sac (AS) with the lung alveolar spatial model (LASM), a 3D spatial biomechanical representation of the AS and its interaction with airflow pressure and the surface tension effects of pulmonary surfactant. We use the LASM to identify the mechanical ramifications of alveolar dynamics associated with ARDS. Using graphical processing unit parallel algorithms, we perform Bayesian inference on the model parameters using experimental data from rat lung under control and Tween-induced ARDS conditions. Our results provide two plausible models that recapitulate two fundamental hypotheses about volume change at the alveolar level: (1) increase in alveolar size through isotropic volume change, or (2) minimal change in AS radius with primary expansion of the mouth of the AS, with the implication that the majority of change in lung volume during the respiratory cycle occurs in the alveolar ducts. These two model solutions correspond to significantly different mechanical properties of the tissue, and we discuss the implications of these different properties and the requirements for new experimental data to discriminate between the hypotheses. PMID:23598859

Christley, Scott; Emr, Bryanna; Ghosh, Auyon; Satalin, Josh; Gatto, Louis; Vodovotz, Yoram; Nieman, Gary F; An, Gary

2013-06-01

272

Lung alveolar proteomics of bronchoalveolar lavage from a pulmonary alveolar proteinosis patient using high-resolution FTICR mass spectrometry  

OpenAIRE

High-resolution Fourier transform ion cyclotron resonance (FTICR) mass spectrometry was developed and applied to the proteome analysis of bronchoalveolar lavage fluid (BALF) from a patient with pulmonary alveolar proteinosis. With use of 1-D and 2-D gel electrophoresis, surfactant protein A (SP-A) and other surfactant-related lung alveolar proteins were efficiently separated and identified by matrix-assisted laser desorption/ionization FTICR mass spectrometry . Low molecular mass BALF protein...

Bai, Yu; Galetskiy, Dmitry; Damoc, Eugen; Ripper, Jan; Woischnik, Markus; Griese, Matthias; Liu, Zhiqiang; Liu, Shuying; Przybylski, Michael

2007-01-01

273

The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells  

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Full Text Available Abstract Background A precise balance exists between the actions of endogenous glucocorticoids (GC and retinoids to promote normal lung development, in particular during alveolarization. The mechanisms controlling this balance are largely unknown, but recent evidence suggests that midkine (MK, a retinoic acid-regulated, pro-angiogenic growth factor, may function as a critical regulator. The purpose of this study was to examine regulation of MK by GC and RA during postnatal alveolar formation in rats. Methods Newborn rats were treated with dexamethasone (DEX and/or all-trans-retinoic acid (RA during the first two weeks of life. Lung morphology was assessed by light microscopy and radial alveolar counts. MK mRNA and protein expression in response to different treatment were determined by Northern and Western blots. In addition, MK protein expression in cultured human alveolar type 2-like cells treated with DEX and RA was also determined. Results Lung histology confirmed that DEX treatment inhibited and RA treatment stimulated alveolar formation, whereas concurrent administration of RA with DEX prevented the DEX effects. During normal development, MK expression was maximal during the period of alveolarization from postnatal day 5 (PN5 to PN15. DEX treatment of rat pups decreased, and RA treatment increased lung MK expression, whereas concurrent DEX+RA treatment prevented the DEX-induced decrease in MK expression. Using human alveolar type 2 (AT2-like cells differentiated in culture, we confirmed that DEX and cAMP decreased, and RA increased MK expression. Conclusion We conclude that MK is expressed by AT2 cells, and is differentially regulated by corticosteroid and retinoid treatment in a manner consistent with hormonal effects on alveolarization during postnatal lung development.

Sweezey Neil B

2009-08-01

274

Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclasts  

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Parathyroid hormone-related protein (PTHrP) plays a major role in the syndrome of humoral hypercalcemia of malignancy (HHM) by its actions on bone and kidney. In this study an isolated osteoclast bone resorption assay was used to investigate the actions of this peptide and the structure-activity relationships for its resorption effect. As with PTH, neither synthetic nor recombinant PTHrP preparations stimulated resorption within highly purified osteoclast populations. Resorption was stimulated only in the presence of contaminating osteoblasts or in cocultures with the osteoblast-like cell line UMR-106. In the presence of osteoblasts PTHrP-(1-34) and PTHrP-(1-84) stimulated bone resorption in a dose-dependent manner with a potency comparable to that of PTH-(1-34) on a molar basis. The biologic activity of the PTHrP was shown to reside in the first 34 amino acids, and within that region the structural requirements for promotion of osteoclastic resorption resembled closely those for promotion of cyclic AMP formation in osteoblast-like cells. Using emulsion autoradiography with iodinated PTHrP-(1-34) and PTHrP-(1-84) on mixed bone cell preparations from neonatal rats, specific binding was demonstrated only to osteoblasts, not to osteoclasts. These results clearly demonstrate that PTHrP is a potent stimulator of bone resorption and that these effects are, like those of PTH, mediated by initial actions upon cells of the osteoblast lineage.

Evely, R.S.; Bonomo, A.; Schneider, H.G.; Moseley, J.M.; Gallagher, J.; Martin, T.J. (St. Vincent' s Institute of Medical Research, Melbourne (Australia))

1991-01-01

275

A supra-cellular model for coupling of bone resorption to formation during remodeling : Lessons from two bone resorption inhibitors affecting bone formation differently  

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The bone matrix is maintained functional through the combined action of bone resorbing osteoclasts and bone forming osteoblasts, in so-called bone remodeling units. The coupling of these two activities is critical for securing bone replenishment and involves osteogenic factors released by the osteoclasts. However, the osteoclasts are separated from the mature bone forming osteoblasts in time and space. Therefore the target cell of these osteoclastic factors has remained unknown. Recent explorations of the physical microenvironment of osteoclasts revealed a cell layer lining the bone marrow and forming a canopy over the whole remodeling surface, spanning from the osteoclasts to the bone forming osteoblasts. Several observations show that these canopy cells are a source of osteoblast progenitors, and we hypothesized therefore that they are the likely cells targeted by the osteogenic factors of the osteoclasts. Here we provide evidence supporting this hypothesis, by comparing the osteoclast-canopy interface in response to two types of bone resorption inhibitors in rabbit lumbar vertebrae. The bisphosphonate alendronate, an inhibitor leading to low bone formation levels, reduces the extent of canopy coverage above osteoclasts. This effect is in accordance with its toxic action on periosteoclastic cells. In contrast, odanacatib, an inhibitor preserving bone formation, increases the extent of the osteoclast-canopy interface. Interestingly, these distinct effects correlate with how fast bone formation follows resorption during these respective treatments. Furthermore, canopy cells exhibit uPARAP/Endo180, a receptor able to bind the collagen made available by osteoclasts, and reported to mediate osteoblast recruitment. Overall these observations support a mechanism where the recruitment of bone forming osteoblasts from the canopy is induced by osteoclastic factors, thereby favoring initiation of bone formation. They lead to a model where the osteoclast-canopy interface is the physical site where coupling of bone resorption to bone formation occurs.

Jensen, Pia Rosgaard; Andersen, Thomas Levin

2014-01-01

276

A supra-cellular model for coupling of bone resorption to formation during remodeling : lessons from two bone resorption inhibitors affecting bone formation differently  

DEFF Research Database (Denmark)

The bone matrix is maintained functional through the combined action of bone resorbing osteoclasts and bone forming osteoblasts, in so-called bone remodeling units. The coupling of these two activities is critical for securing bone replenishment and involves osteogenic factors released by the osteoclasts. However, the osteoclasts are separated from the mature bone forming osteoblasts in time and space. Therefore the target cell of these osteoclastic factors has remained unknown. Recent explorations of the physical microenvironment of osteoclasts revealed a cell layer lining the bone marrow and forming a canopy over the whole remodeling surface, spanning from the osteoclasts to the bone forming osteoblasts. Several observations show that these canopy cells are a source of osteoblast progenitors, and we hypothesized therefore that they are the likely cells targeted by the osteogenic factors of the osteoclasts. Here we provide evidence supporting this hypothesis, by comparing the osteoclast-canopy interface in response to two types of bone resorption inhibitors in rabbit lumbar vertebrae. The bisphosphonate alendronate, an inhibitor leading to low bone formation levels, reduces the extent of canopy coverage above osteoclasts. This effect is in accordance with its toxic action on periosteoclastic cells. In contrast, odanacatib, an inhibitor preserving bone formation, increases the extent of the osteoclast-canopy interface. Interestingly, these distinct effects correlate with how fast bone formation follows resorption during these respective treatments. Furthermore, canopy cells exhibit uPARAP/Endo180, a receptor able to bind the collagen made available by osteoclasts, and reported to mediate osteoblast recruitment. Overall these observations support a mechanism where the recruitment of bone forming osteoblasts from the canopy is induced by osteoclastic factors, thereby favoring initiation of bone formation. They lead to a model where the osteoclast-canopy interface is the physical site where coupling of bone resorption to bone formation occurs.

Jensen, Pia Rosgaard; Andersen, Thomas Levin

2014-01-01

277

Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption - implications for osteoclast quality  

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Full Text Available Abstract Background Normal osteoclasts resorb bone by secretion of acid and proteases. Recent studies of patients with loss of function mutations affecting either of these processes have indicated a divergence in osteoclastic phenotypes. These difference in osteoclast phenotypes may directly or indirectly have secondary effects on bone remodeling, a process which is of importance for the pathogenesis of both osteoporosis and osteoarthritis. We treated human osteoclasts with different inhibitors and characterized their resulting function. Methods Human CD14 + monocytes were differentiated into mature osteoclasts using RANKL and M-CSF. The osteoclasts were cultured on bone in the presence or absence of various inhibitors: Inhibitors of acidification (bafilomycin A1, diphyllin, ethoxyzolamide, inhibitors of proteolysis (E64, GM6001, or a bisphosphonate (ibandronate. Osteoclast numbers and bone resorption were monitored by measurements of TRACP activity, the release of calcium, CTX-I and ICTP, as well as by counting resorption pits. Results All inhibitors of acidification were equally potent with respect to inhibition of both organic and inorganic resorption. In contrast, inhibition of proteolysis by E64 potently reduced organic resorption, but only modestly suppressed inorganic resorption. GM6001 alone did not greatly affect bone resorption. However, when GM6001 and E64 were combined, a complete abrogation of organic bone resorption was observed, without a great effect on inorganic resorption. Ibandronate abrogated both organic and inorganic resorption at all concentrations tested [0.3-100 ?M], however, this treatment dramatically reduced TRACP activity. Conclusions We present evidence highlighting important differences with respect to osteoclast function, when comparing the different types of osteoclast inhibitors. Each class of osteoclast inhibitors will lead to different alterations in osteoclast quality, which secondarily may lead to different bone qualities.

Leeming Diana J

2010-06-01

278

Partial pulmonary embolization disrupts alveolarization in fetal sheep  

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Full Text Available Abstract Background Although bronchopulmonary dysplasia is closely associated with an arrest of alveolar development and pulmonary capillary dysplasia, it is unknown whether these two features are causally related. To investigate the relationship between pulmonary capillaries and alveolar formation, we partially embolized the pulmonary capillary bed. Methods Partial pulmonary embolization (PPE was induced in chronically catheterized fetal sheep by injection of microspheres into the left pulmonary artery for 1 day (1d PPE; 115d gestational age; GA or 5 days (5d PPE; 110-115d GA. Control fetuses received vehicle injections. Lung morphology, secondary septal crests, elastin, collagen, myofibroblast, PECAM1 and HIF1? abundance and localization were determined histologically. VEGF-A, Flk-1, PDGF-A and PDGF-R? mRNA levels were measured using real-time PCR. Results At 130d GA (term ~147d, in embolized regions of the lung the percentage of lung occupied by tissue was increased from 29 ± 1% in controls to 35 ± 1% in 1d PPE and 44 ± 1% in 5d PPE fetuses (p VEGF and Flk-1, although a small increase in PDGF-R? expression at 116d GA, from 1.00 ± 0.12 in control fetuses to 1.61 ± 0.18 in 5d PPE fetuses may account for impaired differentiation of alveolar myofibroblasts and alveolar development. Conclusions PPE impairs alveolarization without adverse systemic effects and is a novel model for investigating the role of pulmonary capillaries and alveolar myofibroblasts in alveolar formation.

Hooper Stuart B

2010-04-01

279

Hemorragia alveolar como complicación del uso de trombolíticos / Alveolar hemorrhage as a complication of thrombolytic therapy  

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Full Text Available SciELO Argentina | Language: Spanish Abstract in spanish La trombolisis se usa como estrategia de reperfusión coronaria en el infarto agudo de miocardio. El sangrado es su principal complicación; la mayoría ocurre en los sitios de accesos venosos y es leve, pero también pueden presentarse hemorragia gastrointestinal, retroperitoneal, genitourinaria, pulmo [...] nar y a nivel del sistema nervioso central, episodios estos generalmente de mayor gravedad y a veces fatales. Se describe aquí el caso de un paciente que recibió terapia trombolítica con estreptoquinasa como tratamiento por un infarto de miocardio, y que posteriormente desarrolló insuficiencia respiratoria aguda, infiltrados pulmonares bilaterales, caída del hematocrito y aumento de la difusión de monóxido de carbono, cuadro compatible con diagnóstico de hemorragia alveolar. Abstract in english Coronary thrombolysis is used as a strategy for coronary reperfusion for acute myocardial infarction. Bleeding is the main complication described. Although most of these events occur at sites of vascular access and are mild, in some cases gastrointestinal, retroperitoneal, genitourinary, lung and ce [...] ntral nervous system bleeding may occur. These episodes are usually serious and sometimes fatal. The following report describes the case of a patient who received thrombolytic therapy with streptokinase as a treatment for myocardial infarction. Subsequently he developed acute respiratory failure, bilateral pulmonary infiltrates and fall of hematocrit compatible with diagnosis of alveolar hemorrhage.

Alejandra, González; Judith, Sagardía; Amorina, Redondo; Marcelo, Villaverde; Alfredo, Monteverde.

2011-12-01

280

Effect of LED-mediated-photobiomodulation therapy on orthodontic tooth movement and root resorption in rats.  

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The aim of this experimental study was to evaluate the effects of light-emitting diode-mediated-photobiomodulation therapy (LPT), on the rate of orthodontic tooth movement (TM) and orthodontically induced root resorption, in rats. Twenty male 12-week-old Wistar rats were separated into two groups (control and LPT) and 50 cN of force was applied between maxillary left molar and incisor with a coil spring. In the treatment group, LPT was applied with an energy density of 20 mW/cm(2) over a period of 10 consecutive days directly over the movement of the first molar teeth area. The distance between the teeth was measured with a digital caliper on days 0 (T0), 10 (T1), and 21 (T2) on dental cast models. The surface area of root resorption lacunae was measured histomorphometrically using digital photomicrographs. Mann-Whitney U and Wilcoxon tests were used for statistical evaluation at p?resorption, expressed as a percentage, showed that the average relative root resorption affecting the maxillary molars on the TM side was 0.098?±?0.066 in the LPT group and 0.494?±?0.224 in the control group. Statistically significant inhibition of root resorption with LPT was determined (p?resorptive activity. PMID:23990217

Ekizer, Abdullah; Uysal, Tancan; Güray, Enis; Akku?, Derya

2015-02-01

281

Degradation of pulmonary surfactant disaturated phosphatidylcholines by alveolar macrophages  

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Experiments were performed to determine whether rat pulmonary surfactant disaturated phosphatidylcholines (DSPC) are degraded by alveolar macrophages in vitro. When [3H]choline-labeled surfactant materials are incubated with unlabeled alveolar macrophages, approximately 40% of the labeled DSPC is broken down in 6 h. There is just a slight decrease in the specific activity of DSPC, which suggests that most products of degradation are not reincorporated into DSPC, at least during the 6-h incubation period. There is a time- and temperature-dependent association of surfactant DSPC with alveolar macrophages, and some of the cell-associated materials are released from the cell fragments after sonication. Association of surfactant with the cells precedes degradation. The breakdown of surfactant DSPC by intact alveolar macrophages lags behind that produced by sonicated cell preparations with disrupted cell membranes. These data and other information suggest that the surfactant materials are internalized by the cells, before the breakdown. The products of degradation probably include free choline and fatty acids, most of which appear in the extracellular fluid. The breakdown processes do not seem to depend on the physical form of the surfactant or on the presence of surfactant apoproteins. Incubation of the cells alone also results in disappearance of intracellular DSPC, some of which may be surfactant phospholipid taken up by the cells in vivo. These results indicate that alvs in vivo. These results indicate that alveolar macrophages can degrade surfactant DSPC and suggest that these cells may be involved in catabolism of pulmonary surfactant materials

282

Acute cigarette smoke exposure increases alveolar permeability in rabbits  

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The authors measured lung clearance of aerosolized technetium-labeled diethylenetriamine pentaacetic acid (/sup 99m/TcDTPA) as an index of alveolar epithelial permeability in rabbits exposed to cigarette smoke. Eighteen rabbits were randomly assigned to 3 equal-size groups: control, all smoke exposure (ASE), and limited smoke exposure (LSE). Cigarette or sham smoke was delivered by syringe in a series of 5, 10, 20, and 30 tidal volume breaths with a 20-min counting period between each subset of breaths to determine /sup 99m/TcDTPA biologic half-life (T1/2). Mean T1/2 minimum was significantly lower for ASE and LSE rabbits than by control rabbits. They observed a significant difference at 20 and 30 breath exposures between the control and ASE group mean values for T1/2, arterial blood pressure, and peak airway pressure. A combination of light and electron microscopy showed focal alveolar edema and hemorrhage in the ASE and LSE groups but no alveolar-capillary membrane damage. In summary, acute cigarette smoke exposure increases alveolar permeability as measured by /sup 99m/TcDTPA clearance, but there was no detectable ultrastructural alteration of the alveolar-capillary membrane

283

Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption.  

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Acid-base disturbances, such as metabolic or respiratory alkalosis, are relatively common in critically ill patients. We examined the effects of alkalosis (hypocapnic or metabolic alkalosis) on alveolar fluid reabsorption in the isolated and continuously perfused rat lung model. We found that alveolar fluid reabsorption after 1 hour was impaired by low levels of CO2 partial pressure (PCO2; 10 and 20 mm Hg) independent of pH levels (7.7 or 7.4). In addition, PCO2 higher than 30 mm Hg or metabolic alkalosis did not have an effect on this process. The hypocapnia-mediated decrease of alveolar fluid reabsorption was associated with decreased Na,K-ATPase activity and protein abundance at the basolateral membranes of distal airspaces. The effect of low PCO2 on alveolar fluid reabsorption was reversible because clearance normalized after correcting the PCO2 back to normal levels. These data suggest that hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption. Conceivably, correction of hypocapnic alkalosis in critically ill patients may contribute to the normalization of lung ability to clear edema. PMID:15764729

Myrianthefs, Pavlos M; Briva, Arturo; Lecuona, Emilia; Dumasius, Vidas; Rutschman, David H; Ridge, Karen M; Baltopoulos, George J; Sznajder, Jacob Iasha

2005-06-01

284

Cediranib for Metastatic Alveolar Soft Part Sarcoma  

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Purpose Alveolar soft part sarcoma (ASPS) is a rare, highly vascular tumor, for which no effective standard systemic treatment exists for patients with unresectable disease. Cediranib is a potent, oral small-molecule inhibitor of all three vascular endothelial growth factor receptors (VEGFRs). Patients and Methods We conducted a phase II trial of once-daily cediranib (30 mg) given in 28-day cycles for patients with metastatic, unresectable ASPS to determine the objective response rate (ORR). We also compared gene expression profiles in pre- and post-treatment tumor biopsies and evaluated the effect of cediranib on tumor proliferation and angiogenesis using positron emission tomography and dynamic contrast-enhanced magnetic resonance imaging. Results Of 46 patients enrolled, 43 were evaluable for response at the time of analysis. The ORR was 35%, with 15 of 43 patients achieving a partial response. Twenty-six patients (60%) had stable disease as the best response, with a disease control rate (partial response + stable disease) at 24 weeks of 84%. Microarray analysis with validation by quantitative real-time polymerase chain reaction on paired tumor biopsies from eight patients demonstrated downregulation of genes related to vasculogenesis. Conclusion In this largest prospective trial to date of systemic therapy for metastatic ASPS, we observed that cediranib has substantial single-agent activity, producing an ORR of 35% and a disease control rate of 84% at 24 weeks. On the basis of these results, an open-label, multicenter, randomized phase II registration trial is currently being conducted for patients with metastatic ASPS comparing cediranib with another VEGFR inhibitor, sunitinib. PMID:23630200

Kummar, Shivaani; Allen, Deborah; Monks, Anne; Polley, Eric C.; Hose, Curtis D.; Ivy, S. Percy; Turkbey, Ismail B.; Lawrence, Scott; Kinders, Robert J.; Choyke, Peter; Simon, Richard; Steinberg, Seth M.; Doroshow, James H.; Helman, Lee

2013-01-01

285

Etiology and prevention of external cervical root resorption associated to teeth bleaching  

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Full Text Available Introduction and objective: Esthetic dentistry has been prioritizedand the desire for whiter teeth has been increasingly present in dental offices, since whiter teeth tend to indicate health, beauty, youth and a more attractive smile. Teeth bleaching is a conservative method widely used to restore the original color of darkened teeth. However, possible relations with the external cervical root resorption have concerned many researchers and clinicians. Literature review: There are many mechanisms that can activate the external cervical root resorption, such as: chemical and physical action of the bleaching materials used, morphology of the cementoenamel junction associated to the immune system, material concentration, traumas and bleaching technique used. Conclusion: Therefore, considering many factors that are still not conclusive, preventing deleterious effects on teeth and support structures, care must be taken when choosing bleaching agent and bleaching technique, as well as when selecting each case, beyond a proper restoration after teeth bleaching.

Eliane Mendes da SILVA

2010-03-01

286

Influencing of resorption and side-effects of salicylic acid by complexing with ?-cyclodextrin  

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After oral administration of 14C-labelled salicylic acid and its ?-cyclodextrin complex to rats, the radioactivity level of the blood reached its maximum during the first 2 h. The blood level obtained with the complex is somewhat but not significantly lower than with free acid. Since the resorption of cyclodextrin is a considerably slower process, it is very likely that the resorption of salicylic acid takes place in the form of free acid after dissociation of the complex. The urinary excretion cumulative curves showed that the free salicylic acid was completely excreted, while about 10% of the salicylic acid administered in the form of complex is lost. The cyclodextrin complex formation increased the pK values of all hydroxybenzoic acids. Direct observations revealed that complex formation decreased the stomach-irritating effect of salicylic acid. The ratio of radioactivity was nearly the same in the organs of animals treated by both free salicylic and cyclodextrin complex. (author)

287

Ameloblastic fibroma of the mandible associated with root resorption and unerupted teeth: a case report.  

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Ameloblastic fibroma (AF) is an uncommon benign odontogenic mixed tumor. A case of an AF associated with unerupted and missing teeth is presented. A 13-year-old girl was referred for evaluation of a painless swelling of her right mandible. The most remarkable finding was the resorption of the proximal root of the permanent first molar. The lesion was completely enucleated. Follow-up showed satisfactory bony healing, and the resorbed root was completely surrounded by a continuous layer of intact lamina dura. In most cases, the patient presents to the clinician complaining of an unerupted tooth at the posterior area of the mandible. The most remarkable finding in our case, however, was the coexisting root resorption. This finding could indicate a more aggressive form of AF. AF has a very good prognosis. Malignant transformation is extremely rare. PMID:19057751

Dimitrakopoulos, Ioannis; Psomaderis, Konstantinos; Zaramboukas, Thomas

2008-06-01

288

Early resorption of an artificial bone graft made of calcium phosphate for cranioplasty: case report  

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Full Text Available Bernardo Assumpção de Monaco, Erich Talamoni Fonoff, Manoel Jacobsen TeixeiraDivision of Functional Neurosurgery, Department of Neurology, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, BrazilAbstract: The treatment of uncomplicated osteoma consists of an en bloc resection, or curettage, of the tumor, followed by cranioplasty. Here, we present a case report of a patient treated for a parietal osteoma, followed by a calcium phosphate cranioplasty, with early resorption after 3 months, which was presented by a sinking flap above the resection area. This case suggests that synthetic cranioplasty should be preferred, even in small skull-gap areas.Keywords: cranioplasty, bone cement, osteoma, calcium phosphate, resorption

Monaco BA

2013-11-01

289

Nitrogen and phosphorus resorption in a neotropical rain forest of a nutrient-rich soil  

Scientific Electronic Library Online (English)

Full Text Available En las selvas tropicales con suelos fértiles se ha observado que la reabsorción de nutrientes de los arboles de las hojas seniles no siempre es baja. Esta falta de consistencia en el resultado es talvez debida en parte a la metodología de reabsorción de nutrientes utilizada. El objetivo de este estu [...] dio fue analizar la reabsorción final de N y P de arboles de la selva húmeda tropical en un suelo rico en nutrientes. La hipótesis planteada fue que en un suelo rico en nutrientes los arboles presentarían una baja reabsorción final de nutrientes. En 30 muestras del suelo superficial (10 cm) de tres sitios de la selva no perturbada, se analizó entre otras características físicas y químicas, la concentración de N total y P extraíble. A través de la concentración de N y P en hojas seniles, se determinó la reabsorción real de 11 especies dominantes de arboles de esta selva. El N se analizó por digestión microkjeldahl con ácido sulfúrico y destilación con ácido bórico, y el P se analizó por digestión con ácido nítrico y destilación con perclórico. El suelo fue rico en N total (0.50%, n = 30) y P extraíble (4.11 µg g-1, n = 30). Tal como se esperaba, los arboles mostraron una reabsorción incompleta para el N (1.13%, n = 11) y P (0.11%, n = 11). Abstract in english In tropical forests with nutrient-rich soil tree’s nutrient resorption from senesced leaves has not always been observed to be low. Perhaps this lack of consistence is partly owing to the nutrient resorption methods used. The aim of the study was to analyse N and P resorption proficiency from tropic [...] al rain forest trees in a nutrient-rich soil. It was hypothesised that trees would exhibit low nutrient resorption in a nutrient-rich soil. The soil concentrations of total N and extractable P, among other physical and chemical characteristics, were analysed in 30 samples in the soil surface (10 cm) of three undisturbed forest plots at ‘Estación de Biología Los Tuxtlas’ on the east coast of Mexico (18°34’ - 18°36’ N, 95°04’ - 95°09’ W). N and P resorption proficiency were determined from senescing leaves in 11 dominant tree species. Nitrogen was analysed by microkjeldahl digestion with sulphuric acid and distilled with boric acid, and phosphorus was analysed by digestion with nitric acid and perchloric acid. Soil was rich in total N (0.50%, n = 30) and extractable P (4.11 µg g-1, n = 30). As expected, trees showed incomplete N (1.13%, n = 11) and P (0.11%, n = 11) resorption. With a more accurate method of nutrient resorption assessment, it is possible to prove that a forest community with a nutrient-rich soil can have low levels of N and P resorption. Rev. Biol. Trop. 53(3-4): 353-359. Epub 2005 Oct 3.

José Luis, Martínez-Sánchez.

2005-09-01

290

Nitrogen and phosphorus resorption in a neotropical rain forest of a nutrient-rich soil  

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Full Text Available In tropical forests with nutrient-rich soil tree’s nutrient resorption from senesced leaves has not always been observed to be low. Perhaps this lack of consistence is partly owing to the nutrient resorption methods used. The aim of the study was to analyse N and P resorption proficiency from tropical rain forest trees in a nutrient-rich soil. It was hypothesised that trees would exhibit low nutrient resorption in a nutrient-rich soil. The soil concentrations of total N and extractable P, among other physical and chemical characteristics, were analysed in 30 samples in the soil surface (10 cm of three undisturbed forest plots at ‘Estación de Biología Los Tuxtlas’ on the east coast of Mexico (18°34’ - 18°36’ N, 95°04’ - 95°09’ W. N and P resorption proficiency were determined from senescing leaves in 11 dominant tree species. Nitrogen was analysed by microkjeldahl digestion with sulphuric acid and distilled with boric acid, and phosphorus was analysed by digestion with nitric acid and perchloric acid. Soil was rich in total N (0.50%, n = 30 and extractable P (4.11 µg g-1, n = 30. As expected, trees showed incomplete N (1.13%, n = 11 and P (0.11%, n = 11 resorption. With a more accurate method of nutrient resorption assessment, it is possible to prove that a forest community with a nutrient-rich soil can have low levels of N and P resorption. Rev. Biol. Trop. 53(3-4: 353-359. Epub 2005 Oct 3.En las selvas tropicales con suelos fértiles se ha observado que la reabsorción de nutrientes de los arboles de las hojas seniles no siempre es baja. Esta falta de consistencia en el resultado es talvez debida en parte a la metodología de reabsorción de nutrientes utilizada. El objetivo de este estudio fue analizar la reabsorción final de N y P de arboles de la selva húmeda tropical en un suelo rico en nutrientes. La hipótesis planteada fue que en un suelo rico en nutrientes los arboles presentarían una baja reabsorción final de nutrientes. En 30 muestras del suelo superficial (10 cm de tres sitios de la selva no perturbada, se analizó entre otras características físicas y químicas, la concentración de N total y P extraíble. A través de la concentración de N y P en hojas seniles, se determinó la reabsorción real de 11 especies dominantes de arboles de esta selva. El N se analizó por digestión microkjeldahl con ácido sulfúrico y destilación con ácido bórico, y el P se analizó por digestión con ácido nítrico y destilación con perclórico. El suelo fue rico en N total (0.50%, n = 30 y P extraíble (4.11 µg g-1, n = 30. Tal como se esperaba, los arboles mostraron una reabsorción incompleta para el N (1.13%, n = 11 y P (0.11%, n = 11.

José Luis Martínez-Sánchez

2005-09-01

291

Management of recurrent fracture of central incisor with internal resorption using light transmitting (luminex post  

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Full Text Available The normal root canal anatomy may be altered in various pathological processes and making it very difficult and at times impossible to achieve ideal obturation by normal methods. Internal resorption is one among them. There are several treatment protocols advised for this pathological condition. A crown-root fracture is defined as a fracture involving enamel, dentin and cementum and accounts for 5% of all traumatic injuries to the permanent dentition. In anterior teeth, these fractures are usually caused by direct trauma and often complicated in fully erupted teeth. In cases where the fracture line extends down along the long axis of the root, extraction of the tooth is indicated. The purpose of this report is to present the use of light transmitting post system to reinforce the crown root fractured maxillary central incisor due to trauma and internal resorption.

Hariharan V

2010-01-01

292

Spontaneous resorption of extruded iliac crest graft ina case of high cervical myelopathy  

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Full Text Available AbstractA 38 year old male patient presented to us with complaints of parasthesias in all four limbs with spastic quadriparesis. Magnetic resonance imaging of cervical spine revealed central disc herniation at C2-C3 level with significant cord compression. He was operated for C2-C3 Smith-Robinson anterior cervical discectomy. An autogenous tricortical iliac crest graft of 1.5×1.0 cm was snugly fitted into the disc space. Postoperative check X-ray of the cervical spine showed extrusion of the graft. The patient was managed conservatively. Repeat X-ray of the cervical spine after follow-up of 6 weeks showed resorption of the graft. The distinct strategy of management in this case along with a brief review of literature is discussed.Key words: High cervical myelopathy: Extruded graft: Resorption

Chatleya A,

2008-01-01

293

Comparison of growth-induced resorption and denervation-induced resorption on the release of [3H]tetracycline, 45calcium, and [3H]collagen from whole bones of growing rats  

International Nuclear Information System (INIS)

The major effect of immobilization during growth is a smaller bone mass induced by either an increased bone resorption or a decreased bone formation. Using a method of analyzing radioisotopic loss of [3H]tetracycline and [3H]collagen from bone prelabeled in vivo, we compared the amount of bone resorption due to immobilization with bone resorption induced by growth. One hind limb was denervated in growing male rats, 6 weeks of age, that had been chronically prelabeled with [3H]tetracycline, 45calcium, and [3H]proline. The total radioactivity of the whole femur and tibia/fibula from the denervated limb was compared with that from bones of the control limb at 0, 1, 2, 4, and 8 weeks after denervation. The effect of growth on bone formation was measured by net increases in bone length, volume, and mass of matrix and mineral. Experimental bones had a significantly smaller volume and mass. Bone resorption was much greater during growth modeling than during denervation. The additional bone resorption induced by denervation was a small fraction (one-fourth) of the resorption induced by growth. Denervation during growth resulted in less bone being formed due to a smaller gain in matrix and mineral mass as a result of a reduction in bone formation

294

Morphological characteristics of frontal sinus and nasal bone focusing on bone resorption and apposition in hypophosphatemic rickets  

DEFF Research Database (Denmark)

To characterize the size and the morphology of the frontal sinus (i.e., structure evolved by bone resorption) and the nasal bone (i.e., structure evolved by bone formation) in adults with hypophosphatemic rickets (HR) compared with controls.

GjØrup, Hans; Kjaer, I

2013-01-01

295

Effects of a bone resorptive factor from human cancer ascites fluid on rat bone cell calcium and cyclic AMP.  

Science.gov (United States)

The effects of a bone resorptive protein isolated from human cancer ascites fluid on bone cell calcium and cyclic AMP were studied with fetal rat cells. The osteoclast-activating factor increased bone cell calcium uptake at 37 degrees C and 4 degrees C with no direct effects on calcium efflux. Concentrations of the resorptive factor that increased in vitro bone resorption and cell calcium uptake had no effect on cyclic AMP. The effects of the protein on calcium uptake were not specific for bone cells, and large increases were also observed in isolated fetal rat skin cells. These studies suggest that increases in the permeability of the cell membrane to calcium are involved in the mechanism of action of the ascites fluid resorptive protein. PMID:6249472

Dziak, R; Chang, Y W; Humphries, D; Lloyd, W; Wells, H; Schmid, K; Nimberg, R B

1980-01-01

296

Mapping nutrient resorption efficiencies of subarctic cryptogams and seed plants onto the Tree of Life.  

Science.gov (United States)

Nutrient resorption from senescing photosynthetic organs is a powerful mechanism for conserving nitrogen (N) and phosphorus (P) in infertile environments. Evolution has resulted in enhanced differentiation of conducting tissues to facilitate transport of photosynthate to other plant parts, ultimately leading to phloem. Such tissues may also serve to translocate N and P to other plant parts upon their senescence. Therefore, we hypothesize that nutrient resorption efficiency (RE, % of nutrient pool exported) should correspond with the degree of specialization of these conducting tissues across the autotrophic branches of the Tree of Life. To test this hypothesis, we had to compare members of different plant clades and lichens within a climatic region, to minimize confounding effects of climatic drivers on nutrient resorption. Thus, we compared RE among wide-ranging basal clades from the principally N-limited subarctic region, employing a novel method to correct for mass loss during senescence. Even with the limited numbers of species available for certain clades in this region, we found some consistent patterns. Mosses, lichens, and lycophytes generally showed low REN (70%). REP appeared higher in eudicots and liverworts than in mosses. Within mosses, taxa with more efficient conductance also showed higher REN. The differences in REN among clades broadly matched the degree of specialization of conducting tissues. This novel mapping of a physiological process onto the Tree of Life broadly supports the idea that the evolution of conducting tissues toward specialized phloem has aided land plants to optimize their internal nitrogen recycling. The generality of evolutionary lines in conducting tissues and nutrient resorption efficiency needs to be tested across different floras in different climatic regions with different levels of N versus P availability. PMID:25360262

Lang, Simone I; Aerts, Rien; van Logtestijn, Richard S P; Schweikert, Wenka; Klahn, Thorsten; Quested, Helen M; van Hal, Jurgen R; Cornelissen, Johannes H C

2014-06-01

297

THE BENEFIT OF SOY BEAN- CHOCOLATE BEVERAGE ON BONE RESORPTION IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS  

OpenAIRE

THE BENEFIT OF SOY BEAN- CHOCOLATE BEVERAGE ON BONE RESORPTION IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS Nur Ainun Rani1, Nurpudji A. Taslim,1,2 Haerani Rasyid1,2, Burhanuddin Bahar3 Department of Clinical Nutrition Faculty of Medicine 1, Department of Nutrition2 Faculty of Medicine, Faculty of Public Health3, Hasanuddin University, Makassar ABSTRACT Background Soybeans and chocolate contain isoflavones, which is the active substance which is recommended as an hormone replacem...

Ainun Rani, Nur; Astuti, Nurpudji; Rasyid, Haerani; Bahar, Burhanuddin

2011-01-01

298

Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption  

OpenAIRE

The causes for the propensity of metastasized prostate cancer cells to grow in bone and to induce osteoblastic lesions remain unresolved. Co-culture of human prostate cancer cell lines with bone slices was determined to increase the level of endothelin-1 (ET-1) mRNA and its production. ET-1 is an ejaculate protein that also stimulates osteoblasts. Osteoclastic bone resorption was significantly blocked by the presence of androgen-independent prostate cancer cells in a dose-dependent manner as ...

Chiao, J. W.; Moonga, B. S.; Yang, Y. M.; Kancherla, R.; Mittelman, A.; Wu-wong, J. R.; Ahmed, T.

2000-01-01

299

Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts.  

OpenAIRE

Mutations in Bruton's tyrosine kinase (Btk) cause the B-cell disorder X-linked agammaglobulinaemia (XLA) in humans, but the effect of Btk deficiency in human bone health has not been investigated previously. In this study, we show that human Btk-deficient osteoclasts are defective at resorption activity in vitro owing to a dysregulation of the actin cytoskeletal function. Contrary to expectation, XLA patients did not exhibit increased bone density or alterations in serum markers of bone turno...

Danks, L.; Workman, S.; Webster, D.; Horwood, Nj

2011-01-01

300

Gallium a unique anti-resorptive agent in bone: Preclinical studies on its mechanisms of action  

Energy Technology Data Exchange (ETDEWEB)

The discovery of gallium as a new and unique agent for the treatment of metabolic bone disorders was in part fortuitous. Gallium is an exciting new therapeutic agent for the treatment of pathologic states characterized by accelerated bone resorption. Compared to other therapeutic metal compounds containing platinum or germanium, gallium affects its antiresorptive action without any evidence of a cytotoxic effect on bone cells. Gallium is unique amongst all therapeutically available antiresorptive agents in that it favors bone formation. 18 refs., 1 fig.

Bockman, R.; Adelman, R.; Donnelly, R.; Brody, L.; Warrell, R. (Hospital for Special Surgery, New York, NY (USA)); Jones, K.W. (Brookhaven National Lab., Upton, NY (USA))

1990-01-01

301

Bone resorption is affected by follicular phase length in female rotating shift workers.  

OpenAIRE

Stressors as subtle as night work or shift work can lead to irregular menstrual cycles, and changes in reproductive hormone profiles can adversely affect bone health. This study was conducted to determine if stresses associated with the disruption of regular work schedule can induce alterations in ovarian function which, in turn, are associated with transient bone resorption. Urine samples from 12 rotating shift workers from a textile mill in Anqing, China, were collected in 1996-1998 during ...

Lohstroh, Pete N.; Chen, Jiangang; Ba, Jianming; Ryan, Louise M.; Xu, Xiping; Overstreet, James W.; Lasley, Bill L.

2003-01-01

302

Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption  

OpenAIRE

Nitric oxide has been suggested to be involved in the regulation of bone turnover, especially in pathological conditions characterized by release of bone-resorbing cytokines. The cytokine IL-1 is thought to act as a mediator of periarticular bone loss and tissue damage in inflammatory diseases such as rheumatoid arthritis. IL-1 is a potent stimulator of both osteoclastic bone resorption and expression of inducible nitric oxide synthase (iNOS) in bone cells and other cell types. In this study,...

T Hof, R. J.; Armour, K. J.; Smith, L. M.; Armour, K. E.; Wei, X. Q.; Liew, F. Y.; Ralston, S. H.

2000-01-01

303

Estrogen directly attenuates human osteoclastogenesis, but has no effect on resorption by mature osteoclasts  

DEFF Research Database (Denmark)

Estrogen deficiency arising with the menopause promotes marked acceleration of bone resorption, which can be restored by hormone replacement therapy. The inhibitory effects of estrogen seem to involve indirect cytokine- mediated effects via supporting bone marrow cells, but direct estrogen-receptor mediated effects on the bone-resorbing osteoclasts have also been proposed. Little information is available on whether estrogens modulate human osteoclastogenesis or merely inhibit the functional activity of osteoclasts. To clarify whether estrogens directly modulate osteoclastic activities human CD14+ monocytes were cultured in the presence of M-CSF and RANKL to induce osteoclast differentiation. Addition of 0.1-10 nM 17beta-estradiol to differentiating osteoclasts resulted in a dose-dependent reduction in tartrate resistant acid phosphatase (TRACP) activity reaching 60% at 0.1 nM. In addition, 17beta-estradiol inhibited bone resorption, as measured by the release of the C-terminal crosslinked telopeptide (CTX), by 60% at 0.1 nM, but had no effect on the overall cell viability. In contrast to the results obtained with differentiating osteoclasts, addition of 17beta-estradiol (0.001-10 nM) to mature osteoclasts did not affect bone resorption or TRACP activity. We investigated expression of the estrogen receptors, using immunocytochemistry and Western blotting. We found that ER-alpha is expressed in osteoclast precursors, whereas ER- beta is expressed at all stages, indicating that the inhibitory effect of estrogen on osteoclastogenesis is mediated by ER-alpha for the major part. In conclusion, these results suggest that the in vivo effects of estrogen are mediated by reduction of osteoclastogenesis rather than direct inhibition of the resorptive activity of mature osteoclasts.

SØrensen, M G; Henriksen, K

2006-01-01

304

FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation  

OpenAIRE

Besides their cell-damaging effects in the setting of oxidative stress, reactive oxygen species (ROS) play an important role in physiological intracellular signalling by triggering proliferation and survival. FoxO transcription factors counteract ROS generation by upregulating antioxidant enzymes. Here we show that intracellular H2O2 accumulation is a critical and purposeful adaptation for the differentiation and survival of osteoclasts, the bone cells responsible for the resorption of minera...

Bartell, Shoshana M.; Kim, Ha-neui; Ambrogini, Elena; Han, Li; Iyer, Srividhya; Serra Ucer, S.; Rabinovitch, Peter; Jilka, Robert L.; Weinstein, Robert S.; Zhao, Haibo; O’brien, Charles A.; Manolagas, Stavros C.; Almeida, Maria

2014-01-01

305

Effect of Nanocrystalline Hydroxyapatite Socket Preservation on Orthodontically Induced Inflammatory Root Resorption  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Orthodontically induced inflammatory root resorption (OIIRR is considered to be an important sequel associated with orthodontic tooth movement (OTM. OTM after Socket preservation enhances the periodontal condition before orthodontic space closure. The purpose of this study is to investigate the histologic effects of NanoBone®, a new highly nonsintered porous nano-crystalline hydroxyapatite bone on root resorption following OTM. Materials and Methods: This experimental study was conducted on four male dogs. In each dog, four defects were created at the mesial aspects of the maxillary and mandibular first premolars. The defects were filled with NanoBone®. We used the NiTi closed coil for mesial movement of the first premolar tooth. When the experimental teeth moved approximately halfway into the defects, after two months, the animals were sacrificed and we harvested the area of interest. The first premolar root and adjacent tissues were histologically evaluated. The three-way ANOVA statistical test was used for comparison. Results: The mean root resorption in the synthetic bone substitute group was 22.87 ± 11.25×10-4 mm2 in the maxilla and 21.41 ± 11.25×10-4 mm2 in the mandible. Statistically, there was no significant difference compared to the control group (p>0.05. Conclusion: The use of a substitution graft in the nano particle has some positive effects in accessing healthy periodontal tissue following orthodontic procedures without significant influence on root resorption (RR. Histological evaluation in the present study showed osteoblastic activity and remodeling environment of nanoparticles in NanoBone®.

Massoud Seifi

2015-01-01

306

MTA resorption and periradicular healing in an open-apex incisor: A case report  

OpenAIRE

This case report describes the periradicular healing and resorption of an unintentional extrusion of mineral trioxide aggregate (MTA) in an open-apex central incisor. A 22-year old female with a symptomatic open-apex right maxillary central incisor associated with a periradicular lesion was referred for evaluation and treatment. After chemomechanical debridement, the apical third of the root canal was filled with MTA to create an apical plug. Postoperative radiographs showed the extrusion of ...

Asgary, Saeed; Ehsani, Sara

2011-01-01

307

Apical root resorption caused by orthodontic forces: A brief review and a long-term observation  

OpenAIRE

External apical root resorption (ARR) is a common iatrogenic consequence of orthodontic treatment. One of the aims of this article is to present a brief overview of the literature, including; diagnosis and etiology, with emphasis on orthodontic forces to facilitate an understand of the prevention or management of ARR in orthodontic patients. We also present a long-term follow-up observation of severe ARR, including the last obtained cone beam computed tomography (CBCT) records, to demonstrate...

Topkara, Ahu; Karaman, Ali I.; Kau, Chung H.

2012-01-01

308

Management of recurrent fracture of central incisor with internal resorption using light transmitting (luminex) post  

OpenAIRE

The normal root canal anatomy may be altered in various pathological processes and making it very difficult and at times impossible to achieve ideal obturation by normal methods. Internal resorption is one among them. There are several treatment protocols advised for this pathological condition. A crown-root fracture is defined as a fracture involving enamel, dentin and cementum and accounts for 5% of all traumatic injuries to the permanent dentition. In anterior teeth, these fractures...

Hariharan V; Nandlal B; Srilatha K

2010-01-01

309

Resorption of apatite-wollastonite containing glass-ceramic and beta-tricalcium phosphate in vivo.  

OpenAIRE

Apatite-wollastonite containing glass ceramic is considered to be difficult to resorb, but we experienced the disappearance of the porous type of Apatite-wollastonite glass ceramic particles . In this study, the resorption of porous apatite-wollastonite glass-ceramic implanted in the femurs of rabbits was investigated, and the process was compared with beta-tricalcium phosphate, a resorbable ceramics. Porous apatite-wollastonite glass-ceramic (70, 80, and 90% porosity) and beta-trica...

Teramoto, Hidefumi; Kawai, Akira; Sugihara, Shinsuke; Yoshida, Aki; Inoue, Hajime

2005-01-01

310

Gallium a unique anti-resorptive agent in bone: Preclinical studies on its mechanisms of action  

International Nuclear Information System (INIS)

The discovery of gallium as a new and unique agent for the treatment of metabolic bone disorders was in part fortuitous. Gallium is an exciting new therapeutic agent for the treatment of pathologic states characterized by accelerated bone resorption. Compared to other therapeutic metal compounds containing platinum or germanium, gallium affects its antiresorptive action without any evidence of a cytotoxic effect on bone cells. Gallium is unique amongst all therapeutically available antiresorptive agents in that it favors bone formation. 18 refs., 1 fig

311

Nitrogen Resorption and Nitrogen Use Efficiency in Cacao Agroforestry Systems Managed Differently in Central Sulawesi  

OpenAIRE

Cacao agroforestry is a traditional form of agriculture practiced by the people of Central Sulawesi. These agroforestry systems vary from a simple system following selective cutting of forest trees, to a more sophisticated planting design. The cacao was planted under remaining forest covers (CF1), under planted trees (CF2), and between shade trees Gliricidia sepium (CP). The objectives of this study were to quantify nitrogen use efficiency (N NUE) and nitrogen resorption in cacao agroforestry...

TRIADIATI; SOEKISMAN TJITROSEMITO; EDI GUHARDJA; SUDARSONO; IBNUL QAYIM; CHRISTOPH LEUSCHNER

2007-01-01

312

Plasma Serotonin and Markers of Bone Formation and Bone Resorption in Hemodialysis Patients  

OpenAIRE

Introduction. Serotonin receptors are present in osteoblasts and osteoclasts, and serotonin affects bone metabolism. The association of plasma serotonin with markers of bone formation and bone resorption in hemodialysis patients was evaluated. Materials and Methods. Twenty-four hemodialysis patients (11 diabetics) and 22 healthy volunteers were enrolled into the study. Serotonin was assessed in platelet-free plasma, whereas the markers of osteoblastic activity N-terminal midfragment osteocalc...

Theodoros Eleftheriadis; Georgia Antoniadi; Vassilios Liakopoulos; Theodora Sparopoulou; Ioannis Stefanidis; Grammati Galaktidou

2013-01-01

313

Relationship between renal stone formation, mitral annular calcification and bone resorption markers  

OpenAIRE

Background and Objectives : Mitral annular calcification (MAC) is associated with osteoporosis and there is evidence of reduced bone mineral density (BMD) in patients with renal stone formation (RSF). Therefore, we designed this study to test if RSF was associated with MAC and if this association could be linked to bone resorption. Methods : Fifty-nine patients (mean age, 41.5 years) with RSF and 40 healthy subjects (mean age, 44.2 years) underwent screening for MAC and BMD, and measuuremen...

Celik Ahmet; Davutoglu Vedat; Sarica Kemal; Erturhan Sakip; Ozer Orhan; Sari Ibrahim; Yilmaz Mustafa; Baltaci Yasemin; Akcay Murat; Al Behcet; Yuce Murat; Yilmaz Necat

2010-01-01

314

Use of Induced Pluripotent Stem Cells to Recapitulate Pulmonary Alveolar Proteinosis Pathogenesis  

OpenAIRE

Rationale: In patients with pulmonary alveolar proteinosis (PAP) syndrome, disruption of granulocyte/macrophage colony–stimulating factor (GM-CSF) signaling is associated with pathogenic surfactant accumulation from impaired clearance in alveolar macrophages.

Suzuki, Takuji; Mayhew, Christopher; Sallese, Anthony; Chalk, Claudia; Carey, Brenna C.; Malik, Punam; Wood, Robert E.; Trapnell, Bruce C.

2014-01-01

315

Alveolar macrophage kinetics and function after interruption of canine marrow function  

International Nuclear Information System (INIS)

To study the kinetics and function of alveolar macrophages after interruption of marrow function, we performed serial bronchoalveolar lavages in dogs. The studies were performed before and after 9.0 to 9.5 Grey total body irradiation and marrow infusion. Monocytes had disappeared from the bloodstream by Day 7 after the irradiation. Alveolar macrophages were significantly decreased at Day 21. At Days 14 and 21 myeloperoxidase-positive alveolar macrophages were also significantly decreased. Beyond Day 30 the number of circulating monocytes, myeloperoxidase-positive and total alveolar macrophages had returned. Sex chromatin stains of alveolar macrophages obtained from a male dog that received female marrow indicated that the repopulating macrophages were of marrow origin. In vitro studies of alveolar macrophage migration and phagocytosis demonstrated increased activities beyond Day 30. These studies suggest that in this model the alveolar macrophage is dependent on the bone marrow for support and that the alveolar macrophage depletion may impair lung defense mechanisms

316

Resorption of apatite-wollastonite containing glass-ceramic and beta-tricalcium phosphate in vivo.  

Directory of Open Access Journals (Sweden)

Full Text Available

Apatite-wollastonite containing glass ceramic is considered to be difficult to resorb, but we experienced the disappearance of the porous type of Apatite-wollastonite glass ceramic particles . In this study, the resorption of porous apatite-wollastonite glass-ceramic implanted in the femurs of rabbits was investigated, and the process was compared with beta-tricalcium phosphate, a resorbable ceramics. Porous apatite-wollastonite glass-ceramic (70, 80, and 90% porosity and beta-tricalcium phosphate (75% porosity were implanted in the femurs of Japanese white rabbits. Samples were harvested and examined 0, 4, 8, 12, 24 and 36 weeks after implantation. Quantitative analysis of the radiographic and histologic findings was performed with NIH Image software. Radiographic examination demonstrated that the radiopacity and size of the porous apatite-wollastonite glassceramic cylinders decreased gradually after implantation. Histologic examination revealed that the surface area of the apatite-wollastonite glass-ceramic cylinders decreased continuously, and approached 20% of the original area 36 weeks after implantation. However, the resorption rate of porous apatite-wollastonite glass-ceramic was slower than that of beta-tricalcium phosphate. Toluidine blue staining showed abundant new bone formation on the surface of the apatite-wollastonite glassceramic matrix. Considering its mechanical strength, gradual resorption characteristics, and good osteochonductive activity, porous apatite-wollastonite glass-ceramic appears to be a suitable artificial bone substitutes.

Teramoto,Hidefumi

2005-10-01

317

3,3'-Diindolylmethane increases bone mass by suppressing osteoclastic bone resorption in mice.  

Science.gov (United States)

3,3'-Diindolylmethane (DIM), a major acid-condensation product or metabolite of indole-3-carbinol which is found in cruciferous vegetables, has been shown to have anticancer, anti-inflammatory, and multiple immune stimulating effects. However, its function in bone metabolism is poorly understood. This study evaluated the effect of DIM on bone mass in mice under physiological and pathological conditions. Eight-week-old female mice received injections of a vehicle or 0.1mg/g of DIM, twice a week for four weeks. We found that DIM treatment significantly increased bone mass as assessed by dual-energy X-ray absorptiometry (DEXA) and micro-computed tomography (?CT). Further, Bone histomorphometric analyses showed that this treatment significantly reduced bone resorption parameters, but did not increase bone formation parameters. Furthermore, we use ovariectomized (OVX)-induced osteoporotic mouse model, and explore function of DIM in skeletal pathological processes. Bone phenotype analyses revealed that the administration of DIM in this study effectively prevented OVX-induced bone loss resulting from increased bone resorption. Our results demonstrated that DIM increased bone mass by suppressing osteoclastic bone resorption in bone metabolism under both physiological and pathological conditions. Accordingly, DIM may be of value in the treatment and the possible prevention of bone diseases characterized by bone loss, such as postmenopausal osteoporosis. PMID:25704022

Yu, Tai-Yong; Pang, Wei-Jun; Yang, Gong-She

2015-01-01

318

Management-related outcomes and radiographic findings of idiopathic condylar resorption: a systematic review.  

Science.gov (United States)

Idiopathic condylar resorption (ICR) is progressive resorption of the condyle of unknown aetiology. There is no consensus on the approaches for diagnostic imaging and management of this disease. The objective of this systematic review was to examine the best practices for imaging and to appraise the success of surgical and non-surgical therapy of ICR. Eleven search engines were queried via explicit literature searches for studies describing ICR, published until 2012. Two authors independently extracted data using predetermined characteristics. Studies that identified patients as having either ICR or progressive condylar resorption and that described the radiographic findings or treatment options were included. Seventeen studies contributing 178 cases met the eligibility criteria. The major radiographic findings, as assessed mostly by two-dimensional imaging, included decreased ramus height, decreased condylar height, altered volume of the condyle, decreased SNB angle and mandibular plane angle, and a retrognathic profile. Treatments included occlusal splints with orthodontic treatment, condylectomy with costochondral graft, and other surgical approaches. This systematic review was limited by the lack of meta-analysis. Nevertheless, we identified the need for future investigations: characterization of findings on three-dimensional imaging and its contribution to treatment planning, outcomes of non-surgical and pharmacological management of ICR, and randomized trials and comparative studies with longer follow-up periods. PMID:25270187

Sansare, K; Raghav, M; Mallya, S M; Karjodkar, F

2015-02-01

319

Controlled release of bisphosphonate from a calcium phosphate biomaterial inhibits osteoclastic resorption in vitro.  

Science.gov (United States)

Calcium phosphate biomaterials such as calcium deficient apatite (CDA) have been contemplated as carrier for delivery of bisphosphonate in bone tissues. In the present work, we have investigated the in vitro biological properties of Zoledronate-loaded CDA. CDA was loaded with zoledronate according to a previously described coating process. 31P MAS NMR spectra demonstrated the effective loading of zoledronate onto CDA. Using 14C labeled zoledronate, we then demonstrated the in vitro release of zoledronate from CDA. In a first set of experiments, we confirmed that Zoledronate reduced the number of TRAP-, vitronectin receptor-, and F-actin ring-positive cells as well as the resorption activity of osteoclasts obtained from a total rabbit bone cell culture. Interestingly, Zoledronate-loaded CDA and its extractive solutions decreased the osteoclastic resorption. Finally, zoledronate-loaded CDA did not affect the viability and alkaline phosphatase activity of primary osteoblastic cells. These data demonstrate that CDA is effective for loading and release of zoledronate. The released zoledronate inhibited osteoclastic resorption without affecting osteoblasts. Our findings therefore suggest that such a drug delivery system would allow an increase in the efficiency of bisphosphonates by being locally available. Further experiments are now required to evaluate the in vivo antiresorptive activity of this concept. PMID:18404716

Faucheux, C; Verron, E; Soueidan, A; Josse, S; Arshad, M D; Janvier, P; Pilet, P; Bouler, J M; Bujoli, B; Guicheux, J

2009-04-01

320

Passive and active in vitro resorption of calcium and magnesium phosphate cements by osteoclastic cells.  

Science.gov (United States)

Biocements are clinically applied materials for bone replacement in non-load-bearing defects. Depending on their final composition, cements can be either resorbed or remain stable at the implantation site. Degradation can occur by two different mechanisms, by simple dissolution (passive) or after osteoclastic bone remodeling (active). This study investigated both the passive and active in vitro resorption behavior of brushite (CaHPO??· 2H?O), monetite (CaHPO?), calcium-deficient hydroxyapatite (CDHA; Ca?(PO?)?HPO?OH), and struvite (MgNH?PO??·?6H?O) cements. Passive resorption was measured by incubating the cement samples in a cell culture medium, whereas active resorption was determined during the surface culture of multinuclear osteoclastic cells derived from RAW 264.7 macrophages. Osteoclast formation was confirmed by showing tartrate resistant acid phosphatase (TRAP) activity on CDHA, brushite, and monetite surfaces, as well as by measuring calcitonin receptor (CT-R) expression as an osteoclast-specific protein by Western blot analysis for struvite ceramics. An absence of passive degradation and only marginally active degradation of struvite cement was the most degradable with a passive (active) release of 9.26 (2.92) Mg²+ ions and a total weight loss of 4.7% over 13 days of the study. PMID:20673025

Grossardt, Christian; Ewald, Andrea; Grover, Liam M; Barralet, Jake E; Gbureck, Uwe

2010-12-01

321

Does increased local bone resorption secondary to breast and prostate cancer result in increased cartilage degradation?  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Breast and prostate cancer patients often develop lesions of locally high bone turnover, when the primary tumor metastasizes to the bone causing an abnormal high bone resorption at this site. The objective of the present study was to determine whether local increased bone turnover in breast and prostate cancer patients is associated with an increase in cartilage degradation and to test in vitro whether osteoclasts or cathepsin K alone generate CTXII from human bone. Methods The study included 132 breast and prostate cancer patient, where presence of bone metastases was graded according to the Soloway score. Total bone resorption (CTXItotal and cartilage degradation (CTXII were determined. Results Breast and prostate cancer patients with bone metastases revealed significant increased levels of CTXItotal at Soloway scores 1 and higher compared to patients without bone metastases (p total significantly decreased at score 3 and 4 (p total, CTXII and CTXII/CTXItotal changed +900%, +130%, and -90%, respectively at Soloway score 4 compared to score 0. The in vitro experiments revealed that osteoclasts released CTXI fragments but not CTXII from bone specimens. The same was observed for cathepsin K. Conclusion Data suggest that an uncoupling between bone resorption and cartilage degradation occurs in breast and lung cancer patient.

Fregerslev Michael

2008-06-01

322

Dioscin inhibits osteoclast differentiation and bone resorption though down-regulating the Akt signaling cascades  

Energy Technology Data Exchange (ETDEWEB)

Highlights: •A natural-derived compound, dioscin, suppresses osteoclast formation and bone resorption. •Dioscin inhibits osteolytic bone loss in vivo. •Dioscin impairs the Akt signaling cascades pathways during osteoclastogenesis. •Dioscin have therapeutic value in treating osteoclast-related diseases. -- Abstract: Bone resorption is the unique function of osteoclasts (OCs) and is critical for both bone homeostasis and pathologic bone diseases including osteoporosis, rheumatoid arthritis and tumor bone metastasis. Thus, searching for natural compounds that may suppress osteoclast formation and/or function is promising for the treatment of osteoclast-related diseases. In this study, we for the first time demonstrated that dioscin suppressed RANKL-mediated osteoclast differentiation and bone resorption in vitro in a dose-dependent manner. The suppressive effect of dioscin is supported by the reduced expression of osteoclast-specific markers. Further molecular analysis revealed that dioscin abrogated AKT phosphorylation, which subsequently impaired RANKL-induced nuclear factor-kappaB (NF-?B) signaling pathway and inhibited NFATc1 transcriptional activity. Moreover, in vivo studies further verified the bone protection activity of dioscin in osteolytic animal model. Together our data demonstrate that dioscin suppressed RANKL-induced osteoclast formation and function through Akt signaling cascades. Therefore, dioscin is a potential natural agent for the treatment of osteoclast-related diseases.

Qu, Xinhua; Zhai, Zanjing; Liu, Xuqiang; Li, Haowei [Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai (China); Ouyang, Zhengxiao [Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai (China); Department of Orthopaedics, Hunan Provincial Tumor Hospital and Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha (China); Wu, Chuanlong [Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai (China); Liu, Guangwang [Department of Orthopaedic Surgery, The Central Hospital of Xuzhou, Affiliated Hospital of Medical Collage of Southeast University, Xuzhou (China); Fan, Qiming; Tang, Tingting [Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai (China); Qin, An, E-mail: dr.qinan@gmail.com [Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai (China); Dai, Kerong, E-mail: krdai@163.com [Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai (China)

2014-01-10

323

Experimental studies on the resorption and translocation of 14C-aldimorph in selected plant species  

International Nuclear Information System (INIS)

Experimental studies were performed with 14C-labelled 4-n-dodecyl-trans-2,6-dimethyl morpholine and both isolated plant segments and intact seedlings of Hordeum distichon L. and Sinapis alba L. to elucidate resorption and transportation of the fungicidal substance aldimorph. The compound is quickly resorbed by isolated roots and leaves during the initial phase, and accumulated in plant tissue. In the steady state of influx/efflux equilibrium, the root concentration factor amounts to 10 with barley roots and the tissue concentration factor is 3 with mustard cotyledons. The relationship between the resorption of active substance and the concentration of ambient solution was found to be linear, thus corroborating a postulated resorption by diffusion. The morpholine derivative also penetrates into the leaf tissue of intact barley seedlings within few hours and at rather high rates. Nevertheless, according to translocation studies aldimorph has to be considered only moderately mobile. However, metabolites originated in the plant, especially during longer trial periods, show markedly improved translocation properties compared with the mother compound. (author)

324

Nectar resorption in flowers of Sinapis alba L., Brassicaceae and Platanthera chlorantha Custer (Rchb.), Orchidaceae  

International Nuclear Information System (INIS)

Full text: In the flowers of Sinapis alba nectar is secreted by two pairs of nectaries and accumulated as drops between filaments and in the cavity of sepals whereas in Platanthera chlorantha nectar is produced and accumulated within a spur. Previous studies of these species revealed that after a period of secretion and cessation, rapid nectar resorption occurs. The aim of this study was the observation of nectar resorption by the nectaries using radiolabelled sucrose. During the peak of secretion the nectar accumulated in unpollinated flowers was replaced with the same volume of labelled sucrose and after 12-48 hrs of incubation, at the resorption phase, parts of S. alba flowers with nectaries as well as fragments of P. chlorantha spur were sampled and fixed for microautoradiographic studies. In S. alba the presence of [14C(U)] sucrose was detected at the base of nectaries, in phloem elements of main vascular strands supplying glands, whereas both epidermis and nectary parenchyma showed no traces of radiolabelled sugars. In P. chlorantha the presence of labelled sucrose was stated mainly in the walls of nectary cells, which indicate an apoplastic route of reabsorbed nectar. (author)

325

Understanding coupling between bone resorption and formation : are reversal cells the missing link?  

DEFF Research Database (Denmark)

Bone remodeling requires bone resorption by osteoclasts, bone formation by osteoblasts, and a poorly investigated reversal phase coupling resorption to formation. Likely players of the reversal phase are the cells recruited into the lacunae vacated by the osteoclasts and presumably preparing these lacunae for bone formation. These cells, called herein reversal cells, cover >80% of the eroded surfaces, but their nature is not identified, and it is not known whether malfunction of these cells may contribute to bone loss in diseases such as postmenopausal osteoporosis. Herein, we combined histomorphometry and IHC on human iliac biopsy specimens, and showed that reversal cells are immunoreactive for factors typically expressed by osteoblasts, but not for monocytic markers. Furthermore, a subpopulation of reversal cells showed several distinctive characteristics suggestive of an arrested physiological status. Their prevalence correlated with decreased trabecular bone volume and osteoid and osteoblast surfaces in postmenopausal osteoporosis. They were, however, virtually absent in primary hyperparathyroidism, in which the transition between bone resorption and formation occurs optimally. Collectively, our observations suggest that arrested reversal cells reflect aborted remodeling cycles that did not progress to the bone formation step. We, therefore, propose that bone loss in postmenopausal osteoporosis does not only result from a failure of the bone formation step, as commonly believed, but also from a failure at the reversal step.

Andersen, Thomas L; Abdelgawad, Mohamed E

2013-01-01

326

Three-dimensional localization of impacted canines and root resorption assessment using cone beam computed tomography.  

Science.gov (United States)

The purpose of this study was to develop a new way to localize the impacted canines from three dimensions and to investigate the root resorption of the adjacent teeth by using cone beam computed tomography (CBCT). Forty-six patients undergoing orthodontic treatments and having impacted canines in Tongji Hospital were examined. The images of CBCT scans were obtained from KaVo 3D exam vision. Angular and linear measurements of the cusp tip and root apex according to the three planes (mid-sagittal, occlusal and frontal) have been taken using the cephalometric tool of the InVivo Dental Anatomage Version 5.1.10. The measurements of the angular and linear coordinates of the maxillary and mandibular canines were obtained. Using this technique the operators could envision the location of the impacted canine according to the three clinical planes. Adjacent teeth root resorption of 28.26 % was in the upper lateral incisors while 17.39% in upper central incisors, but no lower root resorption was found in our samples. Accurate and reliable localization of the impacted canines could be obtained from the novel analysis system, which offers a better surgical and orthodontic treatment for the patients with impacted canines. PMID:24939311

Almuhtaseb, Eyad; Mao, Jing; Mahony, Derek; Bader, Rawan; Zhang, Zhi-xing

2014-06-01

327

Foliar Nitrogen (N, Phosphorus (P Dynamics, and Foliar Resorption of Corylus avellana var. avellana  

Directory of Open Access Journals (Sweden)

Full Text Available Corylus avellana var. avellana (Corylaceae has a widespread distribution in the Central Black Sea Region of Turkey and is very valuable in the food industry and plays an important role in the economy of the Black Sea Region of Turkey. In this study, nitrogen (N and phosphorus (P concentrations along a topographical gradient (from sea level to 550 m and through the growing season (from April to October were investigated. In addition to this, foliar resorption was also studied as resorption efficiency (RE and resorption proficiency (RP which is defined as the proportion of nutrients withdrawn from leaves and the N and P concentrations in senesced leaves, respectively. Statistically significant differences were not found with respect to leaf N concentration and SLA during the growing season although leaf P concentration, leaf N/P ratio and SLA were significantly changed during the growing season. Except for NRE, PRE, ARP, and PRP all of the leaf traits were significantly changed along the topographic gradient. The N/P ratio which is an indicator of N- and P- limitation decreased during the growing season and along the topographic gradient. The N and P concentrations in the senescent leaves of C. avellana was below 50 ?g cm-2 and 3 ?g cm-2, respectively along the topographic gradient and this species is N and P-proficient according to the threshold values. Soil properties along the topographic gradient also changed.

Tugba Bayrak Ozbucak

2011-12-01

328

Growth of a tectonic ridge  

Energy Technology Data Exchange (ETDEWEB)

The 28 June 1992 Landers, California, earthquake of M 7.6 created an impressive record of surface rupture and ground deformation. Fractures extend over a length of more than 80 km including zones of right-lateral shift, steps in the fault zones, fault intersections and vertical changes. Among the vertical changes was the growth of a tectonic ridge described here. In this paper the authors describe the Emerson fault zone and the Tortoise Hill ridge including the relations between the fault zone and the ridge. They present data on the horizontal deformation at several scales associated with activity within the ridge and belt of shear zones and show the differential vertical uplifts. And, they conclude with a discussion of potential models for the observed deformation.

Fleming, R.W.; Messerich, J.A. [Geological Survey, Denver, CO (United States); Johnson, A.M. [Purdue Univ., West Lafayette, IN (United States). Dept. of Earth and Atmospheric Sciences

1997-12-31

329

Alveolar rhabdomyosarcoma involving the mandibular ramus and its surrounding tissues  

International Nuclear Information System (INIS)

Rhabdomyosarcoma, when it occurs in the head and neck, is primarily found in children. Alveolar rhabdomyosarcoma is rarely seen in the oral lesion, comparing to the embryonal and the pleomorphic variants. This is a report of a case of alveolar rhabdomyosarcoma in the mandible in a ten-year old girl who complained of a non-painful swelling on the right cheek. The right lower 1st molar was mobile. Her radiographs revealed an extensive radiolucency with somewhat irregular border on the right mandibular ramus. The right mandibular 1st and 2nd molars lost their lamina dura and were floating. CT images revealed smooth-outlined soft tissue mass occupying the pterygomandibular space, the infratemporal space, and the masseteric muscle with thinning and perforation of the right mandibular angle and ramus. Histopathological and immunohistochemical findings established the final diagnosis of alveolar rhabdomyosarcoma.

330

Alveolar rhabdomyosarcoma involving the mandibular ramus and its surrounding tissues  

Energy Technology Data Exchange (ETDEWEB)

Rhabdomyosarcoma, when it occurs in the head and neck, is primarily found in children. Alveolar rhabdomyosarcoma is rarely seen in the oral lesion, comparing to the embryonal and the pleomorphic variants. This is a report of a case of alveolar rhabdomyosarcoma in the mandible in a ten-year old girl who complained of a non-painful swelling on the right cheek. The right lower 1st molar was mobile. Her radiographs revealed an extensive radiolucency with somewhat irregular border on the right mandibular ramus. The right mandibular 1st and 2nd molars lost their lamina dura and were floating. CT images revealed smooth-outlined soft tissue mass occupying the pterygomandibular space, the infratemporal space, and the masseteric muscle with thinning and perforation of the right mandibular angle and ramus. Histopathological and immunohistochemical findings established the final diagnosis of alveolar rhabdomyosarcoma.

Yoon, Suk Ja; Kang, Byung Cheol [Chonnam National University College of Medicine, Gwangju (Korea, Republic of)

2004-06-15

331

A butterfly shaped alveolar hemorrhage caused by cytomegalovirus.  

Science.gov (United States)

Abstract. We report here a 35 year-old immunocompetent male, with a fulminantly lethal diffuse alveolar hemorrhage caused by CMV pneumonia. The patient was admitted with fever, rust colored sputum and exertional dyspnea. A chest x-ray revealed bilateral alveolar infiltration in a butterfly pattern. Bronchoalveolar lavage (BAL) was performed which revealed alveolar hemorrhage. Microscopic findings of the lavage fluid revealed large numbers of erythrocytes and hemosiderin-laden macrophages. The patient did not improve with empiric antibiotic treatment. High CMV IgG and IgM titers were found in the serum. The patient died from respiratory failure after detection of inclusion bodies on BAL before initiation of antiviral therapy. PMID:21073064

Ciledag, Aydin; Karnak, Demet; Kayacan, Oya

2010-07-01

332

Acute pulmonary alveolar proteinosis due to exposure to cotton dust  

Directory of Open Access Journals (Sweden)

Full Text Available Secondary pulmonary alveolar proteinosis (PAP is rare but may occur in association with malignancy, certain infections, and exposure to inorganic or organic dust and some toxic fumes. This case report describes the second recorded case of PAP due to exposure to cotton dust. A 24-year-old man developed PAP after working as a spinner for eight years without respiratory protection. He was admitted as an emergency patient with very severe dyspnea for four months and cough for several years. Chest X-ray showed bilateral diffuse alveolar consolidation. He died 16 days later, and a diagnosis of acute pulmonary alveolar proteinosis was made at autopsy. The histopathology demonstrated alveoli and respiratory bronchioles filled with characteristic periodic acid Schiff-positive material, which also revealed birefringent bodies of cotton dust under polarized light. Secondary PAP can be fatal and present with acute respiratory failure. The occupational history and characteristic pathology can alert clinicians to the diagnosis.

Thind Gurcharan

2009-01-01

333

Injury of the Inferior Alveolar Nerve during Implant Placement: a Literature Review  

OpenAIRE

Objectives: The purpose of present article was to review aetiological factors, mechanism, clinical symptoms, and diagnostic methods as well as to create treatment guidelines for the management of inferior alveolar nerve injury during dental implant placement.Material and Methods: Literature was selected through a search of PubMed, Embase and Cochrane electronic databases. The keywords used for search were inferior alveolar nerve injury, inferior alveolar nerve injuries, inferior alveolar nerv...

Gintaras Juodzbalys; Hom-Lay Wang; Gintautas Sabalys

2011-01-01

334

Profiling target genes of FGF18 in the postnatal mouse lung: possible relevance for alveolar development.  

OpenAIRE

Better understanding alveolarization mechanisms could help improve prevention and treatment of diseases characterized by reduced alveolar number. Although signaling through fibroblast growth factor (FGF) receptors is essential for alveolarization, involved ligands are unidentified. FGF18, the expression of which peaks coincidentally with alveolar septation, is likely to be involved. Herein, a mouse model with inducible, lung-targeted FGF18 transgene was used to advance the onset of FGF18 expr...

Franco-montoya, Marie-laure; Boucherat, Olivier; Thibault, Christelle; Chailley-heu, Bernadette; Incitti, Roberto; Delacourt, Christophe; Bourbon, Jacques

2011-01-01

335

Leukotriene B4 receptors on guinea pig alveolar eosinophils  

International Nuclear Information System (INIS)

The existence of receptors for LTB4 on highly purified guinea pig alveolar eosinophils was investigated. Massive infiltration of eosinophils in alveolar spaces was induced in guinea pigs by i.v. injections of Sephadex beads G50 (16 mg/kg). Alveolar eosinophils (50 x 10(6) cells) were purified to approximately 98% by Percoll continuous density gradient centrifugation. The binding studies indicated that alveolar eosinophils bind LTB4 in a saturable, reversible and specific manner. Scatchard analysis indicated the existence of high-affinity binding sites (Kd1 = 1.00 ± 0.22 nM; Bmax1 = 966 ± 266 sites/cell) and low-affinity binding sites (Kd2 = 62.5 ± 8.9 nM; Bmax2 = 5557 ± 757 sites/cell). The metabolism of LTB4 by alveolar eosinophils in binding conditions was assessed by RP-HPLC and no significant degradation of [3H]LTB4 was observed. LTB4 dose-dependently stimulated eosinophil migration in both chemokinesis and chemotaxis assays with an EC50 value of 1.30 ± 0.14 and 18.14 ± 1.57 nM, respectively. LTB4 caused a dose-dependent increase in the production of superoxide anion with an apparent EC50 value of 50 x 10(-9) M in the authors experimental conditions. LTB4 also induced a dose-dependent increase in the generation of TxA2 with an EC50 value of 46.2 x 10(-9) M. Taken together, their results demonstrated that guinea pig alveolar eosinophils express two classes of specific receptors for LTB4. The high-affinity binding sites seem associated to chemokinesis and chem associated to chemokinesis and chemotaxis whereas the low-affinity binding sites seem associated to superoxide anion production and generation of TxA2. The existence of LTB4 receptors in eosinophils could explain the presence of these cells in hypersensitivity reactions

336

Screening of protein kinase inhibitors identifies PKC inhibitors as inhibitors of osteoclastic acid secretion and bone resorption  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Bone resorption is initiated by osteoclastic acidification of the resorption lacunae. This process is mediated by secretion of protons through the V-ATPase and chloride through the chloride antiporter ClC-7. To shed light on the intracellular signalling controlling extracellular acidification, we screened a protein kinase inhibitor library in human osteoclasts. Methods Human osteoclasts were generated from CD14+ monocytes. The effect of different kinase inhibitors on lysosomal acidification in human osteoclasts was investigated using acridine orange for different incubation times (45 minutes, 4 and 24 hours. The inhibitors were tested in an acid influx assay using microsomes isolated from human osteoclasts. Bone resorption by human osteoclasts on bone slices was measured by calcium release. Cell viability was measured using AlamarBlue. Results Of the 51 compounds investigated only few inhibitors were positive in both acidification and resorption assays. Rottlerin, GF109203X, Hypericin and Ro31-8220 inhibited acid influx in microsomes and bone resorption, while Sphingosine and Palmitoyl-DL-carnitine-Cl showed low levels of inhibition. Rottlerin inhibited lysosomal acidification in human osteoclasts potently. Conclusions In conclusion, a group of inhibitors all indicated to inhibit PKC reduced acidification in human osteoclasts, and thereby bone resorption, indicating that acid secretion by osteoclasts may be specifically regulated by PKC in osteoclasts.

Boutin Jean A

2010-10-01

337

Role of Exopolysaccharide in Aggregatibacter actinomycetemcomitans–Induced Bone Resorption in a Rat Model for Periodontal Disease  

Science.gov (United States)

Aggregatibacter actinomycetemcomitans a causative agent of periodontal disease in humans, forms biofilm on biotic and abiotic surfaces. A. actinomycetemcomitans biofilm is heterogeneous in nature and is composed of proteins, extracellular DNA and exopolysaccharide. To explore the role played by the exopolysaccharide in the colonization and disease progression, we employed genetic reduction approach using our rat model of A. actinomycetemcomitans-induced periodontitis. To this end, a genetically modified strain of A. actinomycetemcomitans lacking the pga operon was compared with the wild-type strain in the rat infection model. The parent and mutant strains were primarily evaluated for bone resorption and disease. Our study showed that colonization, bone resorption/disease and antibody response were all elevated in the wild-type fed rats. The bone resorption/disease caused by the pga mutant strain, lacking the exopolysaccharide, was significantly less (P < 0.05) than the bone resorption/disease caused by the wild-type strain. Further analysis of the expression levels of selected virulence genes through RT-PCR showed that the decrease in colonization, bone resorption and antibody titer in the absence of the exopolysaccharide might be due to attenuated levels of colonization genes, flp-1, apiA and aae in the mutant strain. This study demonstrates that the effect exerted by the exopolysaccharide in A. actinomycetemcomitans-induced bone resorption has hitherto not been recognized and underscores the role played by the exopolysaccharide in A. actinomycetemcomitans-induced disease. PMID:25706999

Shanmugam, Mayilvahanan; Gopal, Prerna; El Abbar, Faiha; Schreiner, Helen C.; Kaplan, Jeffrey B.; Fine, Daniel H.; Ramasubbu, Narayanan

2015-01-01

338

Role of carbonic anhydrase in bone resorption induced by 1,25 dihydroxyvitamin D3 in vitro  

Science.gov (United States)

The calvaria of 5-to-6-day-old mice treated with 1 x 10 to the -8th M of 1,25(OH)2D3 in vitro for 48 hours are examined in order to study the function of carbonic anhydrase in bone resorption. Calcium concentrations in the culture were measured to assess bone resorption. It is observed that 1,25(OH)2D3 effectively stimulates bone resorption in vitro and the resorption is dose-dependent. The effects of azetazolamide on 1,25(OH)2D3-induced bone resorption are investigated. The data reveal that 1,25(OH)2D3-induced calcium release is associated with an increase in the carbonic anhydrase activity of bone, and bone alkaline phosphatase activity is decreased and acid phosphatase activity is increased in response to 1,25(OH)2D3. A two-fold mechanism for 1,25(OH)2D3-induced bone resorption is proposed; the first mechanism is an indirect activation of osteoclasts and the second involves an interaction between hormone and osteoclast precursors.

Hall, G. E.; Kenny, A. D.

1985-01-01

339

Poliangeíte microscópica com hemorragia alveolar difusa / Microscopic polyangiitis with diffuse alveolar hemorrhage  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Languages: English, Portuguese Abstract in portuguese Poliangeíte microscópica é uma forma de vasculite sistêmica de pequenos vasos, associada aos anticorpos anticitoplasma de neutrófilos, que preferencialmente acomete vênulas, capilares e arteríolas, e que pode, entretanto, envolver artérias e veias. Está entre as vasculites sistêmicas primárias de pe [...] quenos vasos mais freqüentes, e pode ter apresentação clínica indistinguível da granulomatose de Wegener e da síndrome de Churg-Strauss. Estas vasculites de pequenos vasos são histologicamente semelhantes e podem ser diferenciadas pela presença de granulomas na granulomatose de Wegener, ou de quadro clínico-funcional de asma na síndrome de Churg-Strauss. Relata-se o caso de um paciente do sexo masculino de 66 anos com poliangeíte microscópica com hemorragia alveolar difusa como forma de apresentação clínica, com ênfase no diagnóstico diferencial com outras vasculites pulmonares de pequenos vasos. Abstract in english Microscopic Polyangiitis is a form of Anti-Neutrophil Cytoplasmic Antibody (ANCA)- associated small-vessel vasculitis that preferentially involves venules, capillaries and arterioles and may also involve arteries and veins. It is one of the most common primary systemic small-vessel vasculitis. Its c [...] linical presentation is not distinguishable from the Wegener’s granulomatosis (WG) and the Churg-Strauss syndrome (CSS). These types of small-vessel vasculitis are histologically similar and can be differentiated by the presence of granulomatous inflammation in WG or asthma in CSS. The case of a 66-year-old man with microscopic polyangiitis presenting with alveolar hemorrhage is reported with a discussion of the differential diagnosis of other types of pulmonary small-vessel vasculitis.

José Wellington Alves dos, Santos; Gustavo Trindade, Michel; Carlos Eurico da Luz, Pereira; Vera Luiza, Capelozzi; Jader Nascimento, Mileto; Cleber Antonio, Fiorini.

2004-04-01

340

Poliangeíte microscópica com hemorragia alveolar difusa Microscopic polyangiitis with diffuse alveolar hemorrhage  

Directory of Open Access Journals (Sweden)

Full Text Available Poliangeíte microscópica é uma forma de vasculite sistêmica de pequenos vasos, associada aos anticorpos anticitoplasma de neutrófilos, que preferencialmente acomete vênulas, capilares e arteríolas, e que pode, entretanto, envolver artérias e veias. Está entre as vasculites sistêmicas primárias de pequenos vasos mais freqüentes, e pode ter apresentação clínica indistinguível da granulomatose de Wegener e da síndrome de Churg-Strauss. Estas vasculites de pequenos vasos são histologicamente semelhantes e podem ser diferenciadas pela presença de granulomas na granulomatose de Wegener, ou de quadro clínico-funcional de asma na síndrome de Churg-Strauss. Relata-se o caso de um paciente do sexo masculino de 66 anos com poliangeíte microscópica com hemorragia alveolar difusa como forma de apresentação clínica, com ênfase no diagnóstico diferencial com outras vasculites pulmonares de pequenos vasos.Microscopic Polyangiitis is a form of Anti-Neutrophil Cytoplasmic Antibody (ANCA- associated small-vessel vasculitis that preferentially involves venules, capillaries and arterioles and may also involve arteries and veins. It is one of the most common primary systemic small-vessel vasculitis. Its clinical presentation is not distinguishable from the Wegener’s granulomatosis (WG and the Churg-Strauss syndrome (CSS. These types of small-vessel vasculitis are histologically similar and can be differentiated by the presence of granulomatous inflammation in WG or asthma in CSS. The case of a 66-year-old man with microscopic polyangiitis presenting with alveolar hemorrhage is reported with a discussion of the differential diagnosis of other types of pulmonary small-vessel vasculitis.

José Wellington Alves dos Santos

2004-04-01

341

Repopulation of denuded tracheal grafts with alveolar type II cells  

International Nuclear Information System (INIS)

Repopulation of denuded heterotopic tracheal grafts with populations of specific epithelial cell types is one approach to study the differentiation potential of various cell types. This technique has been adopted to delineate the differentiation pathways of alveolar type II cells isolated from rat lungs. Under the conditions of this experiment, the reestablished epithelial lining was alveolar-like, however, ultrastructural analysis of the cells showed them to be like Clara cells. These preliminary results suggest that the secretary cells of the lung parenchyma and terminal airways may share a common ancestry. (author)

342

Alveolar epithelial permeability in bronchial asthma in children  

International Nuclear Information System (INIS)

To evaluate alveolar epithelial permeability (kep) in children with bronchial asthma, 99mTc-DTPA (diethylene triamine penta acetate) aerosol lung inhalation scintigraphies were performed. There was no correlation between the kep value and the severity of asthma. On the other hand, out of 10 cases which had no aerosol deposition defect in the lung field, 4 showed high kep values on the whole lung field and 7 had high kep value areas, particularly apparent in the upper lung field. These results suggest that even when the central airway lesions are mild, severe damage exists in the alveolar region of the peripheral airway. (author)

343

Hypocapnic but Not Metabolic Alkalosis Impairs Alveolar Fluid Reabsorption  

OpenAIRE

Acid-base disturbances, such as metabolic or respiratory alkalosis, are relatively common in critically ill patients. We examined the effects of alkalosis (hypocapnic or metabolic alkalosis) on alveolar fluid reabsorption in the isolated and continuously perfused rat lung model. We found that alveolar fluid reabsorption after 1 hour was impaired by low levels of CO2 partial pressure (PCO2; 10 and 20 mm Hg) independent of pH levels (7.7 or 7.4). In addition, PCO2 higher than 30 mm Hg or metabo...

Myrianthefs, Pavlos M.; Briva, Arturo; Lecuona, Emilia; Dumasius, Vidas; Rutschman, David H.; Ridge, Karen M.; Baltopoulos, George J.; Sznajder, Jacob Iasha

2005-01-01

344

Anaphylaxis and Diffuse Alveolar Hemorrhage Following Bee Sting  

Directory of Open Access Journals (Sweden)

Full Text Available Insect stings and subsequent reactions are com-mon occurrences, but life-threatening systemic reactions are quite rare. Diffuse alveolar hemor-rhage is a clinical entity seen in many different disease processes and includes hemoptysis, anemia, diffuse radiographic pulmonary infiltrates, and hypoxemic respiratory failure, which can be severe. Radiologic features may mimic cardiogenic pulmonary edema, severe infection or uremia. We describe a 23-year-old girl who developed symptoms of anaphylactic shock and diffuse alveolar hemorrhage within 30 minutes following a bee sting.

I??l Fatma Uzel

2013-01-01

345

Alveolar soft part sarcoma of the retro peritoneum  

Directory of Open Access Journals (Sweden)

Full Text Available Alveolar Soft Part Sarcoma (ASPS, also called Alveolar Soft-Tissue Sarcoma, is a rare type of soft-tissue neoplasm with a poor long term prognosis. Such tumors originating in the retro peritoneal space are extremely rare. In this article we discuss a 34-year-old woman who was referred to our hospital with an increasing mass in her left lower abdomen. Ultrasonography and conventional Computed Tomography revealed a large hard mass occupying the left retroperitoneal space with a clear border. The pathological diagnosis was ASPS.

Xin Fan

2010-01-01

346

Alveolar soft part sarcoma of the retro peritoneum  

OpenAIRE

Alveolar Soft Part Sarcoma (ASPS), also called Alveolar Soft-Tissue Sarcoma, is a rare type of soft-tissue neoplasm with a poor long term prognosis. Such tumors originating in the retro peritoneal space are extremely rare. In this article we discuss a 34-year-old woman who was referred to our hospital with an increasing mass in her left lower abdomen. Ultrasonography and conventional Computed Tomography revealed a large hard mass occupying the left retroperitoneal space with a clear border. T...

Xin Fan; Rana Netra; Ming Zhang; Lang Yu

2010-01-01

347

Soft tissue healing in alveolar socket preservation technique: histologic evaluations.  

Science.gov (United States)

After tooth extraction, 14 alveolar sockets were grafted with porous bovine bone mineral particles and covered with non-cross-linked collagen membrane (test group), and 14 alveolar sockets were left uncovered. At 5 and 12 weeks, microvascular density (MVD), collagen content, and amount of lymphocytes (Lym) T and B were analyzed in soft tissue. At 5 weeks, MVD was significantly lower and Lym T was significantly higher in tests than in controls (P resorbable membrane seems to induce an initial and transient modification of the normal wound healing process of the soft tissue. PMID:25006770

Pellegrini, Gaia; Rasperini, Giulio; Obot, Gregory; Farronato, Davide; Dellavia, Claudia

2014-01-01

348

Serial bronchoscopic lung lavage in pulmonary alveolar proteinosis under local anesthesia  

Science.gov (United States)

Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by alveolar accumulation of surfactant composed of proteins and lipids due to defective surfactant clearance by alveolar macrophages. Mainstay of treatment is whole lung lavage, which requires general anesthesia. Herein, we report a case of primary PAP, successfully treated with serial bronchoscopic lung lavages under local anesthesia.

Davis, K. Rennis; Vadakkan, D. Thomas; Krishnakumar, E. V.; Anas, A. Muhammed

2015-01-01

349

The clinical meaning of external cervical resorption in maxillary canine: transoperative dental trauma  

Scientific Electronic Library Online (English)

Full Text Available A reabsorção cervical externa em caninos superiores com vitalidade pulpar em sua quase totalidade está associada a traumatismo dentário decorrente de procedimentos cirúrgicos associado à preparação desse dente para ser tracionado ortodonticamente. Nessa preparação pode se manipular cirurgicamente a [...] junção amelocementária ou luxar o dente com forças excessivas ou com testes de movimentação além dos limites de tolerância estrutural do ligamento periodontal e tecidos cervicais. A exposição dentinária na junção amelocementária é o estopim para se iniciar uma reabsorção cervical externa a partir de uma inflamação induzida na região seguida de reconhecimento antigênico das proteínas dentinárias. A reabsorção cervical externa é indolor, não induz pulpites e tem uma evolução lenta. Em geral, a lesão está associada e recoberta por tecidos moles gengivais que mantêm, por longos períodos, os aspectos clínicos normais, induzindo diagnósticos tardios, quando o processo se aproxima dos limites pulpares. O tratamento endodôntico está indicado apenas em função de procedimentos operatórios que se fazem necessários no espaço pulpar; caso contrário, a reabsorção cervical externa deve ser tratada de forma conservadora, protegendo a polpa dentária e restaurando a função e estética do dente que permanecerá com sua polpa normal. Infelizmente, não sabemos, com base em pesquisas de casuísticas bem estabelecidas, qual é a frequência da reabsorção cervical externa associada a caninos ortodonticamente tracionados. Abstract in english External Cervical Resorption in maxillary canines with pulp vitality is frequently associated with dental trauma resulting from surgical procedures carried out to prepare the teeth for further orthodontic traction. Preparation procedures might surgically manipulate the cementoenamel junction or caus [...] e luxation of teeth due to applying excessive force or movement tests beyond the tolerance limits of periodontal ligament and cervical tissue structures. Dentin exposure at the cementoenamel junction triggers External Cervical Resorption as a result of inflammation followed by antigen recognition of dentin proteins. External Cervical Resorption is painless, does not induce pulpitis and develops slowly. The lesion is generally associated with and covered by gingival soft tissues which disguise normal clinical aspects, thereby leading to late diagnosis when the process is near pulp threshold. Endodontic treatment is recommended only if surgical procedures are rendered necessary in the pulp space; otherwise, External Cervical Resorption should be treated by conservative means: protecting the dental pulp and restoring function and esthetics of teeth whose pulp will remain in normal conditions. Unfortunately, there is a lack of well-grounded research evincing how often External Cervical Resorption associated with canines subjected to orthodontic traction occurs.

Alberto, Consolaro; Mauricio de Almeida, Cardoso; Carolina Dornelas C. M. de, Almeida; Ingrid Araújo Oliveira, Souza; Leopoldino, Capelloza Filho.

2014-12-01

350

Severe root resorption resulting from orthodontic treatment: Prevalence and risk factors  

Scientific Electronic Library Online (English)

Full Text Available OBJETIVO: avaliar a prevalência de reabsorções radiculares externas severas e identificar prováveis fatores de risco decorrentes do tratamento ortodôntico. MÉTODOS: utilizou-se uma amostra selecionada aleatoriamente, composta de radiografias periapicais de incisivos superiores e inferiores, obtidas [...] no mesmo centro radiológico, de pré- e pós-tratamento ortodôntico ativo, de 129 pacientes, de ambos os sexos, tratados por meio da técnica Edgewise Standard. Dois examinadores mensuraram e definiram a reabsorção radicular de acordo com índice proposto por Levander et al., e o grau de reabsorção foi registrado, definindo a reabsorção em quatro graus de severidade. Para avaliar a reprodutibilidade intra- e interexaminadores, adotou-se o índice de coeficiente kappa ponderado. O teste chi-quadrado (?2) foi adotado para avaliar a relação entre a quantidade de reabsorção radicular e o sexo dos pacientes, arcada dentária (superior ou inferior), tratamentos com ou sem extrações, duração do tratamento, forma radicular, estágio do ápice radicular (aberto ou fechado), overjet e overbite no início do tratamento. RESULTADOS: os incisivos centrais superiores apresentaram a maior porcentagem de reabsorção radicular severa, seguidos dos incisivos laterais superiores e dos incisivos laterais inferiores. Entre 959 dentes avaliados, 28 (2,9%) apresentaram reabsorção radicular severa. Os fatores de risco relacionados foram: dentes localizados na região anterossuperior, overjet maior ou igual a 5mm ao início do tratamento, tratamentos envolvendo extrações dentárias, tempo prolongado de terapia e formação radicular completa à época do início do tratamento ortodôntico. CONCLUSÃO: o estudo demonstrou que cuidados devem ser tomados em tratamentos ortodônticos envolvendo extrações, com grande retração de incisivos superiores, tratamentos prolongados e/ou ápice radicular completamente formado no início da terapia ortodôntica. Abstract in english OBJECTIVE: To assess the prevalence of severe external root resorption and its potential risk factors resulting from orthodontic treatment. METHODS: A randomly selected sample was used. It comprised conventional periapical radiographs taken in the same radiology center for maxillary and mandibular [...] incisors before and after active orthodontic treatment of 129 patients, males and females, treated by means of the Standard Edgewise technique. Two examiners measured and defined root resorption according to the index proposed by Levander et al. The degree of external apical root resorption was registered defining resorption in four degrees of severity. To assess intra and inter-rater reproducibility, kappa coefficient was used. Chi-square test was used to assess the relationship between the amount of root resorption and patient's sex, dental arch (maxillary or mandibular), treatment with or without extractions, treatment duration, root apex stage (open or closed), root shape, as well as overjet and overbite at treatment onset. RESULTS: Maxillary central incisors had the highest percentage of severe root resorption, followed by maxillary lateral incisors and mandibular lateral incisors. Out of 959 teeth, 28 (2.9%) presented severe root resorption. The following risk factors were observed: anterior maxillary teeth, overjet greater than or equal to 5 mm at treatment onset, treatment with extractions, prolonged therapy, and degree of apex formation at treatment onset. CONCLUSION: This study showed that care must be taken in orthodontic treatment involving extractions, great retraction of maxillary incisors, prolonged therapy, and/or completely formed apex at orthodontic treatment onset.

Caroline Pelagio Raick, Maués; Rizomar Ramos do, Nascimento; Oswaldo de Vasconcellos, Vilella.

2015-02-01

351

Ridge enlargement using deproteinized bovine bone and a bioresorbable collagen membrane: a tomodensitometric, histologic, and histomorphometric analysis.  

Science.gov (United States)

The aim of this paper was to study, through a clinical case report, the behavior of deproteinized bovine bone (Bio-Oss) covered with a resorbable barrier membrane (Bio-Gide) when used as an onlay grafting material to obtain alveolar bone ridge enlargement. The presence of an existing bone edge allowed placement of an MK III groovy implant and creation of the required space for ridge enlargement, using xenograft particles (Bio-Oss) covered with a resorbable barrier membrane (Bio-Gide), during the same surgical stage. Recording of anatomical landmarks in the three dimensions of space in relation to implant position allowed precise assessment of the graft behavior during the tomodensitometric examinations performed at 6 and 18 months postsurgery. A biopsy was performed at 9 months postsurgery for histologic and histomorphometric analyses. The tomodensitometric images allowed observation of the preservation of the grafted bone volume. The histologic analysis revealed vital bone formation with the remaining Bio-Oss particles; the histomorphometric analysis, at this stage, provided similar percentages of Bio-Oss (27.94%) and newly formed bone (24.07%). This clinical example confirms the biocompatible and osseoconductive properties of Bio-Oss, as well as stability of the bone graft volume. These different elements testify to the advantage of its use for alveolar ridge enlargement. PMID:21556380

Ohayon, Laurent

2011-06-01

352

Hemorragia alveolar masiva por citomegalovirus (CMV) e infección por VIH / Massive alveolar hemorrhage due to cytomegalovirus (CMV) and HIV infection  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish La hemorragia alveolar puede ser la complicación de enfermedades con manifestaciones locales y sistémicas, ambas comparten el mismo concepto fisiopatológico: daño a la microcirculación alveolar. Es una entidad clínica que genera un reto diagnóstico para el médico. El reconocimiento oportuno favorece [...] un tratamiento agresivo, con lo que puede mejorar el pronóstico. A pesar de los avances tecnológicos en el diagnóstico y tratamiento, se mantiene como una condición de elevada morbilidad y mortalidad. Se presenta el caso de una mujer de 42 años con diagnóstico de hemorragia alveolar masiva por citomegalovirus (CMV) e infección por VIH. La forma de presentación es atípica debido a que la mayoría de los casos reportados se presentan como proceso neumónico, siendo infrecuentes los episodios de hemorragia masiva. El diagnóstico se documentó mediante broncoscopia con lavado broncoalveolar y el diagnóstico etiológico con técnicas moleculares utilizando la reacción en cadena de la polimerasa en transcriptasa reversa. Abstract in english Alveolar hemorrhage may be a complication of diseases with local and systemic manifestations. Both share the same pathophysiological concept: damage to the alveolar microcirculation. It is a clinical entity that generates a diagnostic challenge for the physician. Early recognition favors aggressive [...] treatment, which can improve the outcome. Despite the technological advances in its diagnosis and treatment, it is still a condition having high morbidity and mortality. We present the case of a 42-year old woman diagnosed of massive alveolar hemorrhage induced by cytomegalovirus (CMV) and HIV infection. Its presentation is atypical because most reported cases have occurred as a pneumonic process, episodes of massive hemorrhage being uncommon. The diagnosis was documented by bronchoscopy with bronchoalveolar lavage and etiological diagnosis with molecular techniques using reverse transcription polymerase chain reaction.

A., Cortés; E., Peña; R., Vega; G., Reyes; E., Bautista.

2011-03-01

353

Ridge aperture optical antennas  

Science.gov (United States)

Due to diffraction light cannot be focused to a spot smaller than about half its wavelength in the far-field using conventional optics. This poses an obstacle for several practical engineering problems, notably nanolithography. Confining light with an aperture is a straightforward way to generate a sub diffraction-limited spot. Understanding the physics of the apertures provides insight into the design and modeling. This work is based on resonant ridge apertures, particularly bowtie apertures. This geometry provides high transmission while maintaining very good light confinement. The motivation for this work is direct-write nanolithography, although the tools presented have widespread applications. To this end we study nanoscale apertures, identify their transmission characteristics including resonances, and provide the insight necessary for their design. Nanoscale apertures can be used to define patterns by moving them relative to a photoresist. We describe the work leading to a system capable of writing multiple lines in parallel. The quality of the patterns is highly dependent of their fabrication. In this work we use Focused Ion Beam (FIB) milling, the limitations of which are discussed. Understanding and optimizing this procedure is important for successfully fabricating the apertures as well as modeling their performance. Based on the study of the bowtie aperture we show how to enhance its transmission by adding a grating structure to the mask. This is demonstrated experimentally. We also show how a resonant aperture can couple to waveguides which may have photonic applications. We also investigate what happens when the apertures are placed in an array, demonstrating that the transmission can exceed the light incident on the open area by a factor of four in the infrared. This has frequency selective surface applications as well as potential as a sensor. We also show how the aperture array can be designed to trap light in a weakly absorbing layer. Finally we design a bowtie aperture array to enhance the efficiency of thin film silicon solar cells up to 39%.

Kinzel, Edward C.

354

Alveolar osseous defect in rat for cell therapy: preliminary report / Defeito ósseo alveolar em ratos para terapia celular: estudo preliminar  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: Reproduzir um novo modelo de defeito ósseo alveolar em ratos Wistar que será utilizado para terapia genética e estudos com células tronco. Adicionalmente, outro objetivo do presente estudo foi determinar o pico de regeneração óssea do defeito criado na região alveolar do modelo experimenta [...] l. MÉTODOS: Os animais foram aleatoriamente divididos em dois grupos de sete animais. Através de uma incisão gengivobucal foi criado um defeito ósseo medindo 28 mm² de área na região alveolar dos ratos. Os ratos foram sacrificados após duas semanas (n=7) e quatro semanas (n=7) da cirurgia. RESULTADOS: A área média do defeito alveolar após duas semanas de cirurgia foi de 22.27 ± 1.31 mm² e a área média do defeito alveolar após quatro semanas de cirurgia foi de 9.03 ± 1.17 mm². A taxa de formação óssea foi de 5.73 ± 1.31 mm² após duas semanas de cirurgia e de 19 ± 1.17 mm² após quatro semanas de cirurgia. Foi observada diferença estatisticamente significante na taxa de formação óssea entre o grupo dos animais sacrificados com duas e quatro semanas (p=0.003). CONCLUSÃO: Este estudo demonstrou que a maior taxa de regeneração óssea ocorreu no período entre duas e quatro semanas após a cirurgia de criação do defeito ósseo alveolar, portanto esta observação sugere que o período de tempo de quatro semanas será suficiente para avaliar a capacidade de células tronco em regenerar osso em ratos Wistar com defeito ósseo alveolar. Abstract in english PURPOSE: To study were to reproduce an alveolar bone defect model in Wistar rats to be used for testing the efficacy of stem cell therapies. Additionally, we also aimed to determine the osteogenesis process of this osseous defect in the 1 month period post-surgery. METHODS: The animals were randomly [...] divided into two groups of 7 animals each. A gingivobuccal incision was made, and a bone defect of 28 mm² of area was performed in the alveolar region. Animals were killed at 2 weeks after surgery (n=7) and 4 weeks after surgery (n=7). RESULTS: The average area of the alveolar defect at time point of 2 weeks was 22.27 ± 1.31 mm² and the average area of alveolar defect at time point of 4 weeks was 9.03 ± 1.17 mm². The average amount of bone formation at time point of 2 weeks was 5.73 ± 1.31 mm² and the average amount of bone formation at time point of 4 weeks was 19 ± 1.17 mm². Statistically significant differences between the amount of bone formation at 2 weeks and 4 weeks after surgery were seen (p=0.003). CONCLUSION: The highest rate of ossification occurred mostly from 2 to 4 weeks after surgery. This observation suggests that 4 weeks after the bone defect creation should be a satisfactory timing to assess the potential of bone inductive stem cells to accelerate bone regeneration in Wistar rats.

Cassio Eduardo, Raposo-Amaral; Gerson Shigeru, Kobayashi; Ana Beatriz, Almeida; Daniela F., Bueno; Fatima Rodrigues de Souza e, Freitas; Luiz Carlos, Vulcano; Maria Rita, Passos-Bueno; Nivaldo, Alonso.

2010-08-01

355

Reconstruction of alveolar cleft with allogenous bone graft: clinical considerations  

Scientific Electronic Library Online (English)

Full Text Available INTRODUÇÃO: o enxerto ósseo secundário consiste em um procedimento rotineiro no tratamento de pacientes com fissura alveolar. Via de regra, é realizado no final da dentadura mista, na época de erupção do canino permanente, com osso medular autógeno retirado da crista ilíaca. OBJETIVO: o presente art [...] igo discorre sobre a alternativa de enxerto ósseo autógeno realizado com osso alógeno, obtido de banco de ossos humanos, ilustrando o resultado com a apresentação de um caso clínico de fissura alveolar unilateral do lado esquerdo. Abstract in english INTRODUCTION: Secondary bone grafting consists in a routine procedure on the treatment of patients with alveolar cleft. Usually, it is performed by the end of the mixed dentition, when the permanent canine is erupting, with autogenous cancellous bone from the iliac crest. OBJECTIVE: The present arti [...] cle discusses the alternative of autogenous bone grafting with allogeneic bone, obtained from human bone bank, illustrating the result with the presentation of a clinical case of left unilateral alveolar cleft.

Omar Gabriel da, Silva Filho; Terumi Okada, Ozawa; Cláudia, Bachega; Marco Aurélio, Bachega.

2013-12-01

356

Proximal alveolar bone loss in a longitudinal radiographic investigation  

International Nuclear Information System (INIS)

In Sweden people in all age groups now have more remaining teeth than previosly. An investigation has been made to identify some predictors of alveolar bone loss in a 10-year period in subjects with at least 20 remaining teeth. The material consisted of 349 individuals, examined radiographically, clinically and by interview in 1970 and in 1980. These subjects, born in 1904-1952, constituted a subgroup, with regard to remaining teeth, of an unselected sample of the population of the old county of Stockholm. In the unselected sample statistically significant predictors of alveolar bone loss found in a stepwise multiple regression analysis were 1) alveolar bone loss in 1970, 2) age, 3) number of lost teeth and 4) Russell's Periodontol Index (PI). In the subgroup the predictors were in the order 1) Russell's PI and 2) smoking. The prediction values (R2) of further variables were marginal. The analyses showed that there was an interaction between PI and smoking, implying that the effect of smoking on alveolar bone loss was increased in individuals with high PI values. Furthermore, a tendency was found for a dose-response effect of tobacco consumption. This tendency almost disappeared when controlling for PI

357

Is there correlation between alveolar and systemic bone density?  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: avaliar a correlação entre a densidade óssea alveolar maxilomandibular e a densidade mineral óssea sistêmica. MÉTODOS: a absorciometria duoenergética por raios X do osso alveolar maxilomandibular (região anterior e posterior), dos sítios sistêmicos padrões (coluna lombar e fêmur) e da terc [...] eira vértebra cervical foi realizada em 23 mulheres de meia idade. Radiografias periapicais dos incisivos superiores também foram obtidas com uma escala de alumínio como referência para a leitura digital da densidade óssea da região apical. RESULTADOS: o teste de correlação de Spearman revelou que a densidade da região apical foi correlacionada com a do colo femoral (r = 0,433; p Abstract in english OBJECTIVE: The present study assessed the correlation between maxillomandibular alveolar bone density and systemic bone mineral density (BMD). METHODS: Dual-energy X-ray absorptiometry of the anterior and posterior maxillomandibular alveolar bone, of the standard sites for the measurement of BMD (lu [...] mbar spine and femur) and the third cervical vertebra was performed on 23 middle-aged women. Periapical radiographs were also obtained, with an aluminum step-wedge as reference for the digital reading of apical bone density of the upper incisors. RESULTS: Spearman's correlations coefficients revealed that density in the apical region was correlated with that of the femoral neck (r = 0.433; p

Paula Cabrini, Scheibel; Adilson Luiz, Ramos; Lilian Cristina Vessoni, Iwaki.

2013-10-01

358

Abnormal gallium scintigraphy in pulmonary alveolar proteinosis (PAP)  

International Nuclear Information System (INIS)

A patient with medulloblastoma of the cerebellum developed dyspnea and hypoxemia. Pulmonary function tests showed decreased lung volume and diffusing capacity, while the chest radiographs initially showed only mild interstitial infiltrates. Repeated gallium scans showed diffuse lung uptake and diagnosis of pulmonary alveolar proteinosis was made by open lung biopsy

359

Fas (CD95) Induces Alveolar Epithelial Cell Apoptosis in Vivo  

Science.gov (United States)

Activation of the Fas/FasL system induces apoptosis of susceptible cells, but may also lead to nuclear factor ?B activation. Our goal was to determine whether local Fas activation produces acute lung injury by inducing alveolar epithelial cell apoptosis and by generating local inflammatory responses. Normal mice (C57BL/6) and mice deficient in Fas (lpr) were treated by intranasal instillation of the Fas-activating monoclonal antibody (mAb) Jo2 or an irrelevant control mAb, and studied 6 or 24 hours later using bronchoalveolar lavage (BAL), histopathology, DNA nick-end-labeling assays, and electron microscopy. Normal mice treated with mAb Jo2 had significant increases in BAL protein at 6 hours, and BAL neutrophils at 24 hours, as compared to lpr mice and to mice treated with the irrelevant mAb. Neutrophil recruitment was preceded by increased mRNA expression for tumor necrosis factor-?, macrophage inflammatory protein-1?, macrophage inflammatory protein-2, macrophage chemotactic protein-1, and interleukin-6, but not interferon-?, transforming growth factor-?, RANTES, eotaxin, or IP-10. Lung sections from Jo2-treated normal mice showed neutrophilic infiltrates, alveolar septal thickening, hemorrhage, and terminal dUTP nick-end-labeling-positive cells in the alveolar septae and airspaces. Type II pneumocyte apoptosis was confirmed by electron microscopy. Fas activation in vivo results in acute alveolar epithelial injury and lung inflammation, and may be important in the pathogenesis of acute lung injury. PMID:11141488

Matute-Bello, Gustavo; Winn, Robert K.; Jonas, Mechthild; Chi, Emil Y.; Martin, Thomas R.; Liles, W. Conrad

2001-01-01

360

Alveolar soft-part sarcoma presenting with multiple intracranial metastases  

OpenAIRE

A 28-year-old man presented with history of raised intracranial pressure and one episode of generalized tonic clonic seizures. Computed Tomogram revealed multiple contrast enhancing intracranial lesions. Biopsy of one of the lesions was reported as metastatic alveolar soft part sarcoma. He was advised whole brain radiotherapy.

Sujit Kumar G; Chacko Geeta; Chacko Ari; Rajshekhar Vedantam

2004-01-01

361

Alveolar soft-part sarcoma of the neck  

Energy Technology Data Exchange (ETDEWEB)

We report a case of alveolar soft-part sarcoma involving the posterior paraspinal musculature of the neck. This rare tumor of uncertain histogenesis typically occurs in the lower extremities in young adults and in the tongue or orbit in infants. (orig.)

Silbergleit, Richard; Agrawal, Rajneesh; Patel, Suresh C. [Department of Diagnostic Radiology and Medical Imaging, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 (United States); Savera, Adnan T. [Department of Pathology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202 (United States)

2002-10-01

362

Alveolar soft-part sarcoma presenting with multiple intracranial metastases  

Directory of Open Access Journals (Sweden)

Full Text Available A 28-year-old man presented with history of raised intracranial pressure and one episode of generalized tonic clonic seizures. Computed Tomogram revealed multiple contrast enhancing intracranial lesions. Biopsy of one of the lesions was reported as metastatic alveolar soft part sarcoma. He was advised whole brain radiotherapy.

Sujit Kumar G

2004-04-01

363

Alveolar soft-part sarcoma of the neck  

International Nuclear Information System (INIS)

We report a case of alveolar soft-part sarcoma involving the posterior paraspinal musculature of the neck. This rare tumor of uncertain histogenesis typically occurs in the lower extremities in young adults and in the tongue or orbit in infants. (orig.)

364

Biomimetics of fetal alveolar flow phenomena using microfluidics.  

Science.gov (United States)

At the onset of life in utero, the respiratory system begins as a liquid-filled tubular organ and undergoes significant morphological changes during fetal development towards establishing a respiratory organ optimized for gas exchange. As airspace morphology evolves, respiratory alveolar flows have been hypothesized to exhibit evolving flow patterns. In the present study, we have investigated flow topologies during increasing phases of embryonic life within an anatomically inspired microfluidic device, reproducing real-scale features of fetal airways representative of three distinct phases of in utero gestation. Micro-particle image velocimetry measurements, supported by computational fluid dynamics simulations, reveal distinct respiratory alveolar flow patterns throughout different stages of fetal life. While attached, streamlined flows characterize the shallow structures of premature alveoli indicative of the onset of saccular stage, separated recirculating vortex flows become the signature of developed and extruded alveoli characteristic of the advanced stages of fetal development. To further mimic physiological aspects of the cellular environment of developing airways, our biomimetic devices integrate an alveolar epithelium using the A549 cell line, recreating a confluent monolayer that produces pulmonary surfactant. Overall, our in vitro biomimetic fetal airways model delivers a robust and reliable platform combining key features of alveolar morphology, flow patterns, and physiological aspects of fetal lungs developing in utero. PMID:25759753

Tenenbaum-Katan, Janna; Fishler, Rami; Rothen-Rutishauser, Barbara; Sznitman, Josué

2015-01-01

365

Modified edentulous ridge expansion technique and immediate implant placement: a 3-year follow-up.  

Science.gov (United States)

Restoration of the edentulous alveolar ridge with implants often requires the ridge width to be augmented to allow its placement. The aim of this study was to evaluate the split-crest technique, with subepithelial connective tissue graft used as biological barrier, in patients with narrow ridges, focusing on the status of soft and hard tissues and on implant success rate, at 36 months after implant loading. Thirteen patients (6 males and 7 females), ages 32-68 years (mean 49.4 years) with an atrophic maxillary jaw underwent modified edentulous ridge expansion technique for implant placement. A total of 33 Laser-Lok tapered internal implant, were placed in the maxilla. The following parameters were evaluated: (1) initial ridge width (time t0); (2) ridge width at the time of abutment connection (time t1); four months after implants placement, healing abutments were connected and the prosthetic rehabilitation was initiated, and all patients were evaluated clinically and radiographically with periapical radiograph at intervals of 3-6 months for the first year and annually thereafter for 3 years. The ridge width was measured with a cone beam computed tomography. The initial ridge width ranged from 3.5 mm to 7 mm (mean: 4.67 mm), while at the end of the expansion procedure the width ranged from 6.3 mm to 11.0 mm (mean: 8.2 mm). The width gain of the edentulous ridge ranged from 1.45-4.9 mm (mean: 3.5 mm). Two implants became exposed 1 month after surgery. One implant was lost before loading (3%). The diameter of failed implant was 5.8 mm and length was 10.5 mm. The remaining 32 implants were stable and free of complications at the end of the study. Thus, the implant survival rate was 97%. Because no implant failed after loading, the cumulative survival rate of loaded implants was 100%. The minimally invasive regenerative technique presented here avoids the use of bone graft, secondary surgery for soft tissue augmentation, and mechanical expansion devices. However, the follow-up period for outcome evaluation and exiguous patient's number in this series was limited. PMID:23641728

Santagata, Mario; Guariniello, Luigi; Tartaro, Gianpaolo

2015-04-01

366

Effects of Nonsurgical Periodontal Treatment on the Alveolar Bone Density  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese O objetivo desse estudo foi avaliar os efeitos do tratamento periodontal não cirúrgico na densidade do osso alveolar e na altura óssea alveolar usando radiografias digitais diretas. Dezenove pacientes (média de idade 36±7,3 anos) com pacientes com periodontite crônica generalizada foram examinados n [...] o tempo 0 e aos 90 (90AT) e 180 (180AT) dias após o tratamento periodontal não cirúrgico. Dois grupos de sítios foram radiografados, 39 com profundidade de bolsa a sondagem (PBS)?3 mm e nível de inserção clínica (NIC)?1 mm (sítios rasos) e 62 com PBS?5 mm and NIC?3 mm (sítios profundos). A densidade foi avaliada considerando as regiões ósseas de interesse na crista óssea alveolar (ROI I) e no osso medular (ROI II). A altura óssea compreendia a distância entre a crista óssea alveolar e a junção cemento-esmalte. Os sítios profundos mostraram um significante aumento na densidade óssea na ROI I tendo p Abstract in english The aim of this study was to evaluate the effects of nonsurgical periodontal treatment on alveolar bone density (ABD) and bone height (BH) using direct digital radiography. Nineteen patients (mean age: 36±7.3 years) with generalized chronic periodontitis were examined at baseline, 90 (90AT) and 180 [...] (180AT) days after nonsurgical periodontal therapy. Radiographs were taken from two sites with specific characteristics: 39 sites with probing pocket depth (PPD)?3 mm and clinical attachment level (CAL)?1 mm (shallow sites); and 62 sites with PPD?5 mm and CAL?3 mm (deep sites). The ABD was assessed considering the bone regions of interest at the alveolar bone crest (ROI I) and at the medullar bone (ROI II). The BH was assessed considering the distance from the alveolar bone crest to the cementoenamel junction. Mann-Whitney test was used for the overall demographic data, Wilcoxon test was used to compare the baseline, 90AT and 180AT data as well as to compare the groups and subgroups within the same evaluation period. The significance level was set at 5%. The deep sites showed a significant increase of ABD in ROI I at 90AT (p

Fabiana Cervo de, Barros; Flávia Farah, Braga; Ricardo Guimarães, Fischer; Carlos Marcelo da Silva, Figueredo.

2014-04-01

367

Reduction in bone resorption by exogenous glucagon-like peptide-2 administration requires an intact gastrointestinal tract  

DEFF Research Database (Denmark)

OBJECTIVE: Biochemical markers for bone resorption (s-CTX) are reduced by food intake, whereas markers for bone formation seem to be unaffected by meal status. Glucagon-like peptide-2 (GLP-2) is a peptide secreted from endocrine L cells in the intestinal mucosa in relation to food-intake. Subcutaneous GLP-2 treatment has been shown to reduce bone resorption in postmenopausal women. The objective of this study was to investigate the ability of exogenous GLP-2 to reduce bone resorption in patients with jejunostomy or ileostomy and to elucidate whether an intact gastrointestinal tract and the ability to secrete GLP-2 are required for meal-induced inhibition of bone resorption. MATERIAL AND METHODS: Fifteen control subjects, 13 colectomized patients with an ileostomy and 12 colectomized patients with a jejunostomy (remnant small bowel 89 +/- 53 cm) were given: a) a subcutaneous injection of 1600 microg GLP-2, b) placebo and c) 3.8 MJ of a breakfast meal. Blood was sampled for measurements of s-CTX, s-osteocalcinand GLP-2 for 4 h after each intervention. RESULTS: After the GLP-2 injection, only control subjects showed a significant reduction in s-CTX (24% +/- 13%, p = 0.05, 120 min) compared with baseline values. Patients with an ileostomy had a preserved endogenous postprandial GLP-2 secretion, which was absent in patients with a jejunostomy. Consumption of a meal reduced s-CTX in all groups but significantly less so in the jejunostomy group. CONCLUSIONS: Reductions in bone resorption by exogenous GLP-2 require an intact gastrointestinal tract. The decreased meal-induced inhibition of bone resorption in the jejunostomy patients, who lack a GLP-2 response, supports the view that GLP-2 plays a role in postprandial reduction in bone resorption.

Gottschalck, Ida B; Jeppesen, Palle B

2008-01-01

368

Three-dimensional analysis of alveolar wall destruction in the early stage of pulmonary emphysema.  

Science.gov (United States)

The morphological mechanism of alveolar wall destruction during pulmonary emphysema has not been clarified. The aim of this study was to elucidate this process three-dimensionally. Lung specimens from five patients with pulmonary emphysema were used, and five controls with normal alveolar structure were also examined. Sections 150 ?m thick were stained with hematoxylin and eosin, elastica, and silver impregnation, and immunostained with selected antibodies. We examined these sections three-dimensionally using a laser confocal microscope and a light microscope. There were only a few Kohn's pores and no fenestrae in the normal alveoli from the controls. In the lungs of the emphysema patients a small rupture appeared in the extremely thin alveolar wall among the alveolar capillaries. This rupture enlarged to form a circle surrounded by the capillaries, which was called an alveolar fenestra. Two neighboring fenestrae fused by breakdown of the collapsed or cord-like capillary between them to form a large fenestra. The large fenestrae fused repeatedly to become larger, and these were bordered by thick elastic fibers constructing an alveolar framework. Alveolar wall destruction during emphysema could start from small ruptures of the alveolar wall that become fenestrae surrounded by capillaries, which fuse repeatedly to become larger fenestrae rimmed with elastic fibers. The alveolar capillary network could initially prevent enlargement of the fenestrae, and the thick elastic fibers constituting the alveolar framework could secondarily prevent destruction of the alveolar wall structure. Clin. Anat. 28:227-234, 2015. © 2014 Wiley Periodicals, Inc. PMID:25220884

Kobayashi, Yukihiro; Uehara, Takeshi; Kawasaki, Kenji; Sugano, Mitsutoshi; Matsumoto, Takehisa; Matsumoto, Gou; Honda, Takayuki

2015-03-01

369

Bone resorption is affected by follicular phase length in female rotating shift workers.  

Science.gov (United States)

Stressors as subtle as night work or shift work can lead to irregular menstrual cycles, and changes in reproductive hormone profiles can adversely affect bone health. This study was conducted to determine if stresses associated with the disruption of regular work schedule can induce alterations in ovarian function which, in turn, are associated with transient bone resorption. Urine samples from 12 rotating shift workers from a textile mill in Anqing, China, were collected in 1996-1998 during pairs of sequential menstrual cycles, of which one was longer than the other (28.4 vs. 37.4 days). Longer cycles were characterized by a prolonged follicular phase. Work schedules during the luteal-follicular phase transition (LFPT) preceding each of the two cycles were evaluated. All but one of the shorter cycles were associated with regular, forward phase work shift progression during the preceding LFPT. In contrast, five longer cycles were preceded by a work shift interrupted either by an irregular shift or a number of "off days." Urinary follicle-stimulating hormone levels were reduced in the LFPT preceding longer cycles compared with those in the LFPT preceding shorter cycles. There was greater bone resorption in the follicular phase of longer cycles than in that of shorter cycles, as measured by urinary deoxypyridinoline. These data confirm reports that changes in work shift can lead to irregularity in menstrual cycle length. In addition, these data indicate that there may be an association between accelerated bone resorption in menstrual cycles and changes of regularity in work schedule during the preceding LFPT. PMID:12676625

Lohstroh, Pete N; Chen, Jiangang; Ba, Jianming; Ryan, Louise M; Xu, Xiping; Overstreet, James W; Lasley, Bill L

2003-04-01

370

Notch signaling induces root resorption via RANKL and IL-6 from hPDL cells.  

Science.gov (United States)

In this study, we first investigated the expressions of Jagged1, Notch2, the receptor activator of nuclear factor-kappa?B ligand (RANKL), and interleukin (IL)-6 in areas of root resorption during experimental tooth movement in rats in vivo. We then assessed the effects of compression force (CF) with or without GSI (an inhibitor of Notch signaling) on Jagged1, RANKL, and IL-6 release from human periodontal ligament (hPDL) cells. Twelve male 6-wk-old Wistar rats were subjected to an orthodontic force of 50?g to induce mesially tipping movement of the upper first molars for 7?d. The expression levels of tartrate-resistant acid phosphatase, Jagged1, Notch2, IL-6, and RANKL proteins in the dental root were determined using an immunohistochemical analysis. Furthermore, the effects of the CF on Jagged1, IL-6, and RANKL production were investigated using hPDL cells in vitro. The effects of the cell-conditioned medium obtained from the hPDL cells subjected to CF (CFM) and Jagged 1 on osteoclastogenesis of human osteoclast precursor cells (hOCPs) were also investigated. Under the conditions of experimental tooth movement in vivo, resorption lacunae with multinucleated cells were observed in the 50 g group. In addition, immunoreactivity for Jagged1, Notch2, IL-6, and RANKL was detected on day 7 in the PDL tissue subjected to the orthodontic force. In the in vitro study, the compression force increased the production of Jagged1, IL-6, and RANKL from the hPDL cells, whereas treatment with GSI inhibited the production of these factors in vitro. The osteoclastogenesis increased with the CFM and rhJagged1, and the increase in the osteoclastogenesis was almost inhibited by GSI. These results suggest that the Notch signaling response to excessive orthodontic forces stimulates the process of root resorption via RANKL and IL-6 production from hPDL cells. PMID:25376720

Kikuta, J; Yamaguchi, M; Shimizu, M; Yoshino, T; Kasai, K

2015-01-01

371

Feline immunodeficiency virus (FIV) infection leads to increased incidence of feline odontoclastic resorptive lesions (FORL).  

Science.gov (United States)

Feline odontoclastic resorptive lesions (FORL), previously known as 'neck lesions,' are commonly known in domestic, but also in non-domestic cats. They are characterized by odontoclastic resorptive processes, which take place at the dental root and at the periodontium. Chronic inflammation of gingiva and periodontium is believed to be an important etiological factor in the development of FORL. In this context, various feline viruses have been discussed to play a relevant role in the pathogenesis of these lesions. The aim of this project was to determine in a blinded study the incidence of FORL in 10 cats which were infected for several years with feline immunodeficiency virus (FIV), but were otherwise free of feline viral infections (feline leukemia virus, feline calicivirus, feline herpesvirus, feline parvovirus, feline coronavirus, feline syncytium-forming virus). Nine age-matched controls were kept under identical conditions, but free of FIV. Subgingival resorptive lesions were found in six of 10 FIV-positive cats, but in three of nine controls only. FIV-positive cats had significantly more often gingivae with an increased tendency for bleeding upon probing than FIV-negative cats (p=0.0055), and they had slightly more often hyperplastic gingivae (p=0.0867). In conclusion, signs characteristic of FORL such as subgingival lesions, granulomatous or hyperplastic gingivae with a tendency for bleeding, were found significantly more often in FIV-positive cats than in the controls (p=0.0198). Therefore, it was concluded that FIV infection is an important factor for the occurrence of FORL, possibly through immune suppression or changes of the (sub)gingival micro-environment. However, non-infected control cats also showed some evidence of FORL in the absence of all tested viral infections. Therefore, factors other than viral infections must also play a role in the development of FORL in cats. PMID:9839881

Hofmann-Lehmann, R; Berger, M; Sigrist, B; Schawalder, P; Lutz, H

1998-10-23

372

Inhibition of bone resorption and growth of breast cancer in the bone microenvironment.  

Science.gov (United States)

Breast cancer frequently metastasizes to bone, where tumor cells induce osteoclasts to locally destroy bone. During bone resorption, growth factors are locally released that may support bone metastatic growth. Differently from most other tissues, drugs that can limit local turnover, such as bisphosphonates and osteoprotegerin (OPG), are available for bone. We examined the hypothesis that inhibition of bone resorption by two different mechanisms may also affect the growth of cancer cells in bone. For this, we tested the effects of high doses of OPG and zoledronic acid (ZOL) on progression of MDA-231-B/Luc+ breast cancer cells in the bone microenvironment using whole body bioluminescent reporter imaging (BLI). Both treatments significantly inhibited the development of radiographically detectable osteolytic lesions. Histologic examination corroborated the radiographic findings, showing that both treatments preserved the integrity of bone trabeculae and prevented bone destruction (significantly higher trabecular bone volumes vs. vehicle). However, whereas practically no TRAcP-positive osteoclasts were observed in tibiae preparations of animals treated with Fc-OPG, TRAcP-positive osteoclasts were still present in the animals treated with ZOL. Intra-bone tumor burden was reduced with ZOL and Fc-OPG treatment. Although there appeared to be a trend for less overall total tumor burden upon treatment with both compounds, this was not significant as assessed by BLI and histomorphometric analysis due to the extramedullary growth of cancer cells which was not affected by these treatments. Collectively, anti-resorptive agents with different mechanisms of action - ZOL and OPG - significantly reduced cancer-induced osteolysis and intra-osseous tumor burden, but failed to restrain local tumor growth. However, interference with the bone micro-environmental growth support could still be of therapeutic relevance when given to patients early in the course of bone metastatic disease. PMID:19041433

Buijs, Jeroen T; Que, Ivo; Löwik, Clemens W G M; Papapoulos, Socrates E; van der Pluijm, Gabri

2009-02-01

373

Nectar resorption and translocation in Cucurbita pepo L. and Platanthera chlorantha Custer (Rchb.).  

Science.gov (United States)

Nectar resorption and sugar translocation were studied in Cucurbita pepo (Cucurbitaceae) and Platanthera chlorantha (Orchidaceae) by micro-autoradiography. In both species, nectar was resorbed in pollinated and unpollinated flowers and ovules developing into seeds were found to be the main sugar sink. In C. pepo, the mobility of resorbed sugars in pollinated female flowers was higher than in unpollinated ones; male flowers showed lower mobility of resorbed sugar. In P. chlorantha, radioactivity was detected in pollinated flowers below and above labelled unpollinated ones: the nearer the flower, the stronger the accumulation of label in developing fruits. PMID:16883483

Nepi, M; Stpiczy?ska, M

2007-01-01

374

Percutaneous resorption of cesium-137 and strontium-89 in alkali solutions and deactivation of burned surface  

International Nuclear Information System (INIS)

Experiments on white rats studied percutaneous resorption of 137Cs and 89Sr during their skin application in the form of 10 per cent and 40 per cent solutions of NaOH. The study also involved deactivation of the contaminated skin by means of traditional means of first aid recommended for alkali burn and the application of 5 per cent solution of boric acid with the addition of some detergent or 10 per cet solution of sodium hexametaphosphate. The dependence of deactivation efficacy on the time of beginning sanitary treatment, decontamination procedure and alkali concentration was established

375

Condylar resorption of the temporomandibular joint: how do we treat it?  

Science.gov (United States)

Condylar resorption (CR) is a common sequela of some temporomandibular joint (TMJ) abnormalities. CR can result in jaw deformities and dysfunction, malocclusion, pain, headaches, and airway obstruction. Most cases can be classified into 1 of 4 categories based on cause: (1) adolescent internal CR; (2) reactive (inflammatory) arthritis; (3) autoimmune and connective tissue diseases; and (4) other end-stage TMJ pathologic abnormality. MRI is helpful in differentiating the cause and defining treatment options. This article presents the nature and progression of the different TMJ CR pathologic abnormalities, clinical and imaging characteristics, and treatment options to produce predictable and stable outcomes. PMID:25483444

Wolford, Larry M; Gonçalves, João Roberto

2015-02-01

376

Iron resorption and iron stores in piglets after intramuscular injection of 59Fe-iron dextran  

International Nuclear Information System (INIS)

Iron resorption from intramuscular injection of an iron dextran complex (Fedex) is almost complete in piglets one week after injection. The excess of resorbed iron is stored in liver and spleen. The stored iron is made available for the growing pig since half of the iron recorded on the 14th day after injection is used during the third week. The remaining iron stores might well be enough to cover the needs for the fourth week also, although it is not absolutely necessary for the pigs at this age. (orig.)

377

Direct measurement of bone resorption and calcium conservation during vitamin D deficiency or hypervitaminosis D  

OpenAIRE

When bone is remodeled during the growth of a given size bone to a larger size, some bone is resorbed and some is deposited. Much of the resorbed bone mineral, calcium, can be reutilized during bone formation. The net and absolute effects of normal growth, vitamin D deficiency, or vitamin D excess were compared on bone resorption, bone formation, and calcium reutilization. Growing chicks were prelabeled extensively with three isotopes: 45Ca, [3H]tetracycline, and [3H]proline. Data were obtain...

Klein, Leroy

1980-01-01

378

Comparison of the inhibitory effect of nonsteroidal antiinflammatory drugs on bone prostaglandin synthesis and resorption.  

Science.gov (United States)

The biopotency of various nonsteroidal antiinflammatory drugs (NSAID) in inhibiting prostaglandin (PG) mediated bone resorption was evaluated in a neonatal mouse calvaria organ culture system. Thrombin stimulated formation of the osteolytic PG, PGE2 and PGI2 (measured as 6-keto-PGF1 alpha) and the concomitant stimulation of calcium release from cultured bone were inhibited by diclofenac much greater than indomethacin much greater than flurbiprofen greater than piroxicam greater than acemetacin much greater than acetylsalicylic acid. The relative potencies of the NSAID on PG synthesis in bone differs from that observed previously in other model systems. PMID:3379625

Klaushofer, K; Hoffmann, O; Czerwenka, E; Leis, H J; Gleispach, H; Koller, K; Peterlik, M

1988-03-01

379

External resorption presenting as an intracoronal radiolucent lesion in a pre-eruptive tooth.  

LENUS (Irish Health Repository)

A large intracoronal radiolucent lesion in an unerupted permanent molar was found during the routine assessment of a young male Caucasian prior to orthodontic treatment. The tooth was extracted. Histological examination indicated the lesion was caused by external resorption. The defect extended widely into the enamel and dentine, and was repaired in part by bone. The pulp chamber was not involved. The aetiology of these lesions is often obscure but in this case it appeared to have originated in the floor of two developmental pits on the occlusal surface of the tooth.

McNamara, C M

1997-09-01

380

Novel use of a Dektak 150 surface profiler unmasks differences in resorption pit profiles between control and Charcot patient osteoclasts.  

Science.gov (United States)

We hypothesized that newly formed osteoclasts from patients with acute Charcot osteoarthropathy can resorb surfaces of bone more extensively compared with controls. Peripheral blood monocytes, isolated from eight Charcot patients and nine controls, were cultured in vitro on 24-well plates and bovine bone discs in duplicate with macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor ?? ligand (RANKL). Osteoclast formation was assessed by tartrate-resistant acid phosphatase staining (TRAcP) at day 17. Resorption was measured at day 21 after toluidine blue staining by two methods: (1) area of resorption at the surface by image analysis (%) and (2) area of resorption under the surface (?m(2)) measured by a Dektak 150 Surface Profiler. Ten 1,000 ?m-long scans were performed per disc. Pits were classified as unidented, bidented, and multidented according to their shape. Although the number of newly formed TRAcP positive multinucleated cells (>3 nuclei) was similar in M-CSF + RANKL-treated cultures between controls and Charcot patients, the latter exhibited increased resorbing activity. The area of resorption on the surface by image analysis was significantly greater in Charcot patients compared with controls (21.1 % [14.5-26.2] vs. 40.8 % [35.4-46.0], median [25-75th percentile], p controls. Resorption in Charcot patients was mediated by highly aggressive newly formed osteoclasts from monocytes eroding large and deep areas of bone. PMID:24322885

Petrova, Nina L; Petrov, Peter K; Edmonds, Michael E; Shanahan, Catherine M

2014-04-01

381

The Ridge, the Glasma and Flow  

Energy Technology Data Exchange (ETDEWEB)

I discuss the ridge phenomena observed in heavy ion collisions at RHIC. I argue that the ridge may be due to flux tubes formed from the Color Glass Condensate in the early Glasma phase of matter produced in such collisions.

McLerran,L.

2008-09-15

382

ConcepTest: Magnetism Across Oceanic Ridge  

Science.gov (United States)

The figure below represents a magnetic profile across an oceanic ridge system. The profile is a plot of (A) distance from the oceanic ridge vs. (B) _________. a. magnetic declination b. magnetic intensity c. ...

383

ConcepTest: Axis of Ridge  

Science.gov (United States)

This is part of a magnetic profile across an oceanic ridge system. The profile shows both positive and negative anomalies. Based on the symmetry of the patterns, where is the axis of the ridge located? a. A b. B c. ...

384

The Ridge, the Glasma and Flow  

OpenAIRE

I discuss the ridge phenomena observed in heavy ion collisions at RHIC. I argue that the ridge may be due to flux tubes formed from the Color Glass Condensate in the early Glasma phase of matter produced in such collisions

Mclerran, Larry

2008-01-01

385

La resorción como proceso inflamatorio: Aproximación a la patogenia de las resorciones dentaria y periodontal / Resorption as an inflammatory process: An approach to the pathogenesis of dental and periodontal resorption  

Scientific Electronic Library Online (English)

Full Text Available SciELO Spain | Language: Spanish Abstract in spanish Se considera aquí a la resorción (inflamación) y a la reparación como dos fases de un conjunto: 1º) la fase de resorción, catabólica o destructiva y 2º) la fase reparativa, anabólica o de síntesis. La similitud de los agentes agresores, de las citocinas intermediarias y de las formas de reparación p [...] ermiten pensar que las resorciones dentarias y óseas de causa local son fenómenos inflamatorio-reparativos asentados sobre tejidos mineralizados. Se justifica este concepto unificador de las patogenias de la resorción y de la inflamación. Se recuerdan, a la luz de los conocimientos clásicos, los agentes agresores (las etiologías) y los fundamentos sobre el origen, desarrollo, grupos celulares y factores humorales que regulan las inflamaciones y las resorciones (la patogenia). Se analizan los últimos hallazgos que explican el por qué y el cómo las células blásticas (osteoblastos y odontoblastos), a través del sistema autocrino-paracrino RANK-RANKL-OPG, son imprescindibles en los procesos de clastogénesis y de resorción-reparación dentaria y periodontal de causa local. Abstract in english Resorption (inflammation) and repair are considered two phases of a whole: 1) the resorptive, catabolic or destructive phase and 2) the repairing, anabolic or synthesis phase. The similarity of the aggressive agents, intermediating cytokines and the restorative forms allows us think that dental and [...] bone resorptions of local origin are inflammatoryrepairing processes located in mineralised tissues. This unifying concept is justified by the resorption and inflammation pathogenesis. The aggressive agents (the aetiologies), the basics about the origins, development, cell groups and humoral factors that regulate inflammations and resorptions (the pathogenesis) are reviewed based on classical knowledge. Recent findings that explain why and how blast cells (osteoblasts and odontoblasts), through the RANK-RANKL-OPG autocrine-paracrine system are essential in the clastogenesis and the dental and periodontal resorption-repairing processes of local origin are analysed.

Guillermo, Del Nero-Viera.

2005-12-01

386

Predisposição genética, hereditariedade e reabsorções radiculares em Ortodontia: cuidados com interpretações precipitadas: uma análise crítica do trabalho de Al-Qawasmi et al Genetics predisposition, heredity and radicular resorption, in Orthodontics: cares with precipitated interpretations and a critical analysis of Al-Qawasmi´s work  

Directory of Open Access Journals (Sweden)

Full Text Available O trabalho de Al-Qawasmi et al.¹, publicado em março de 2003 pelo American Journal of Orthodontics and Dentofacial Orthopedics, procurou estabelecer uma predisposição genética para justificar as reabsorções dentárias em Ortodontia, mas apresentou algumas limitações metodológicas e equívocos na interpretação de seus resultados. A análise criteriosa deste artigo ressalta que, na maioria, estas limitações foram mencionadas e reconhecidas pelos autores na discussão do trabalho, mas o seu resumo e título foram muito taxativos e conclusivos. A linguagem de estudos genéticos nem sempre é familiar a todos os clínicos e isto também requer uma análise esclarecedora à luz de uma visão mais aplicada ao cotidiano ortodôntico. Referenciar ou citar este trabalho de Al-Qawasmi et al.¹, para afirmar de forma taxativa que se demonstrou a natureza hereditária das reabsorções dentárias em Ortodontia, pode denotar falta de conhecimento sobre o assunto ou uma leitura ou compreensão apenas do seu título. Ou ainda, a citação deste trabalho como prova definitiva de associação entre hereditariedade e reabsorções dentárias em Ortodontia pode traduzir também o desejo de excluir da prática clínica a responsabilidade de planejar de forma individualizada e detalhada cada tratamento com base no conhecimento das possibilidades e limitações técnicas oferecidas pela ciência ortodôntica, bem como nas suas bases biológicas, por exemplo, valorizando a morfologia radicular e da crista óssea alveolar e o papel dos cementoblastos na proteção da superfície radicular.The study published in the American Journal of Orthodontics and Dentofacial Orthopedics last March by Al-Qawasmi et al. tried to implicate dental resorption during orthodontic treatment to genetic predisposition. The methodology used, however, presents limitations and interpretative mistakes of the results. When analyzing the article sensibly, one is able to find that these limitations, mostly acknowledged and mentioned by the authors in the discussion, does not allow concluding as they did in the end or even being so decisive in the abstract. Since most clinicians are not familiar with genetic terminology, an elucidative analysis is required in order to apply this knowledge to everyday life in orthodontic practice. When referencing or citating Al-Qawasmi et al. one must be careful its limitations acknowledged by the authors themselves, despite their decisive title. Affirming that the referred paper demonstrates the heritable nature of root resorption in Orthodontics may reveal lack of knowledge on the subject, an inappropriate interpretation of it or even the exclusive reading of its title. In another hypothesis, citating this study as decisive scientific proof of heritability implicated in dental resorption in Orthodontics may indicate the wish to exonerate the clinician of responsibility to consider root and alveolar crest morphology when individualizing treatment plan based on a deeper knowledge of Orthodontic techniques.

Alberto Consolaro

2004-05-01

387

Leukotriene B4 receptors on guinea pig alveolar eosinophils  

Energy Technology Data Exchange (ETDEWEB)

The existence of receptors for LTB4 on highly purified guinea pig alveolar eosinophils was investigated. Massive infiltration of eosinophils in alveolar spaces was induced in guinea pigs by i.v. injections of Sephadex beads G50 (16 mg/kg). Alveolar eosinophils (50 {times} 10(6) cells) were purified to approximately 98% by Percoll continuous density gradient centrifugation. The binding studies indicated that alveolar eosinophils bind LTB4 in a saturable, reversible and specific manner. Scatchard analysis indicated the existence of high-affinity binding sites (Kd1 = 1.00 {plus minus} 0.22 nM; Bmax1 = 966 {plus minus} 266 sites/cell) and low-affinity binding sites (Kd2 = 62.5 {plus minus} 8.9 nM; Bmax2 = 5557 {plus minus} 757 sites/cell). The metabolism of LTB4 by alveolar eosinophils in binding conditions was assessed by RP-HPLC and no significant degradation of (3H)LTB4 was observed. LTB4 dose-dependently stimulated eosinophil migration in both chemokinesis and chemotaxis assays with an EC50 value of 1.30 {plus minus} 0.14 and 18.14 {plus minus} 1.57 nM, respectively. LTB4 caused a dose-dependent increase in the production of superoxide anion with an apparent EC50 value of 50 {times} 10(-9) M in the authors experimental conditions. LTB4 also induced a dose-dependent increase in the generation of TxA2 with an EC50 value of 46.2 {times} 10(-9) M. Taken together, their results demonstrated that guinea pig alveolar eosinophils express two classes of specific receptors for LTB4. The high-affinity binding sites seem associated to chemokinesis and chemotaxis whereas the low-affinity binding sites seem associated to superoxide anion production and generation of TxA2. The existence of LTB4 receptors in eosinophils could explain the presence of these cells in hypersensitivity reactions.

Maghni, K.; de Brum-Fernandes, A.J.; Foeldes-Filep, E.G.; Gaudry, M.; Borgeat, P.; Sirois, P. (Department of Pharmacology, Faculty of Medicine University of Sherbrooke, Quebec (Canada))

1991-09-01

388

Endodontic Treatment in Submerged Roots: A Case Report  

Science.gov (United States)

Alveolar ridge resorption has long been considered an unavoidable consequence of tooth extraction. While the extent and pattern of resorption is variable among individuals, there is a progressive loss of ridge contour as a result of physiologic bone remodeling. Even today, with best modalities of tooth preservation, there is a group of elderly individuals who do not bene?t from modern preventive practices and who now present a dilemma in terms of maintaining the masticatory apparatus necessary for nutrition. Even with excellent dental care, such patients experience abrasion of the natural tooth crowns with age, and embedded roots are left within the alveolar bone. According to old concepts of dental care, extraction of these roots would have been recommended, but today’s goal of excellence in endodontics dictates otherwise. We report a case in which vital and non-vital root submergence was carried out to prevent alveolar ridge reduction. PMID:22991600

Pameshwar Hiremath, Hemalatha; S. Doshi, Yogesh; Siddayya Kulkarni, Sadanand; Kumar Purbay, Saurav

2010-01-01

389

Oak Ridge callibration recall program  

Energy Technology Data Exchange (ETDEWEB)

A development effort was initiated within the Oak Ridge metrology community to address the need for a more versatile and user friendly tracking database that could be used across the Oak Ridge complex. This database, which became known as the Oak Ridge Calibration Recall Program (ORCRP), needed to be diverse enough for use by all three Oak Ridge facilities, as well as the seven calibration organizations that support them. Various practical functions drove the initial design of the program: (1) accessible by any user at any site through a multi-user interface, (2) real-time database that was able to automatically generate e-mail notices of due and overdue measuring and test equipment, (3) large memory storage capacity, and (4) extremely fast data access times. In addition, the program needed to generate reports on items such as instrument turnaround time, workload projections, and laboratory efficiency. Finally, the program should allow the calibration intervals to be modified, based on historical data. The developed program meets all of the stated requirements and is accessible over a network of computers running Microsoft Windows software.

Falter, K.G.; Wright, W.E. [Oak Ridge National Lab., TN (United States); Pritchard, E.W. [Oak Ridge Centers for Manufacturing Technology, TN (United States)] [and others

1996-12-31

390

Mid-Ocean Ridge Spreading  

Science.gov (United States)

In this earth science activity (page 14 of the PDF), learners use layers of closed-cell foam to create their own model of the mid-ocean ridge in order to simulate seafloor spreading. Although this was created as a post-visit activity for a workshop about earth processes, it also makes an excellent stand alone activity.

COSI

2009-01-01

391

Mid-Ocean Ridge Observations  

Science.gov (United States)

Students work in partners during class to make observations about the East Pacific Rise and Mid-Atlantic Ridge from Google Earth images. They also examine samples of typical oceanic crust and upper mantle and use relative density to predict the appropriate rock sequence.

Jamie Levine

392

27 CFR 9.158 - Mendocino Ridge.  

Science.gov (United States)

...2010-04-01 2010-04-01 false Mendocino Ridge. 9.158 Section 9.158 Alcohol...Viticultural Areas § 9.158 Mendocino Ridge. (a) Name. The name of the viticultural...described in this section is “Mendocino Ridge.” (b) Approved maps. The...

2010-04-01

393

How to measure alterations in alveolar barrier function as a marker of lung injury.  

Science.gov (United States)

The alveolar capillary membrane maintains the proper water and solute content of the epithelial lining fluid at the alveolar air-liquid interface, which is critical for adequate gas exchange in the lung. This is possible due to the alveolar fluid clearance (AFC) capacity of this membrane that assists in the removal of salt and water from the alveolar air spaces. The alveolar capillary membrane also provides a barrier that restricts the passage of proteins and water from the interstitial and vascular compartments into the alveolar air spaces. This restricted passage is due to the presence of tight junctions between adjacent alveolar epithelial cells. Severe injury to the alveolar epithelial/endothelial membrane results in increased protein permeability and impairment of AFC, which leads to the formation of protein-rich edema with the consequent deterioration of gas exchange. Many animal models of lung injury, focused on damage of the alveolar-capillary membrane, assess the AFC capacity and the barrier function. We describe a simple method to assess the AFC rate in normal and pathological conditions in mice. We also describe two complementary methods to assess the alveolar-capillary barrier function, which require measuring the concentration of endogenous plasma proteins in bronchoalveolar lavage fluid and detection of tight-junction proteins in lung tissue by immunofluorescence. © 2015 by John Wiley & Sons, Inc. PMID:25645245

Herrero, Raquel; Matute-Bello, Gustavo

2015-01-01

394

Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury  

Science.gov (United States)

Background Alveolar macrophages play an important role during the development of acute inflammatory lung injury. In the present study, in vivo alveolar macrophage depletion was performed by intratracheal application of dichloromethylene diphosphonate-liposomes in order to study the role of these effector cells in the early endotoxin-induced lung injury. Methods Lipopolysaccharide was applied intratracheally and the inflammatory reaction was assessed 4 hours later. Neutrophil accumulation and expression of inflammatory mediators were determined. To further analyze in vivo observations, in vitro experiments with alveolar epithelial cells and alveolar macrophages were performed. Results A 320% increase of polymorphonuclear leukocytes in bronchoalveolar lavage fluid was observed in macrophage-depleted compared to macrophage-competent lipopolysaccharide-animals. This neutrophil recruitment was also confirmed in the interstitial space. Monocyte chemoattractant protein-1 concentration in bronchoalveolar lavage fluid was significantly increased in the absence of alveolar macrophages. This phenomenon was underlined by in vitro experiments with alveolar epithelial cells and alveolar macrophages. Neutralizing monocyte chemoattractant protein-1 in the airways diminished neutrophil accumulation. Conclusion These data suggest that alveolar macorphages play an important role in early endotoxin-induced lung injury. They prevent neutrophil influx by controlling monocyte chemoattractant protein-1 production through alveolar epithelial cells. Alveolar macrophages might therefore possess robust anti-inflammatory effects. PMID:15972102

Beck-Schimmer, Beatrice; Schwendener, Reto; Pasch, Thomas; Reyes, Livia; Booy, Christa; Schimmer, Ralph C

2005-01-01

395

Tumor necrosis factor mediates temporomandibular joint bone tissue resorption in rheumatoid arthritis.  

Science.gov (United States)

Abstract Objective. To investigate if TNF, IL-1 or their endogenous controls, in relation to ACPA, are associated with radiological signs of ongoing temporomandibular joint (TMJ) bone tissue resorption and disc displacement in RA patients. Methods. Twenty-two consecutive outpatients with TMJ of RA were included. Systemic inflammatory activity was assessed by DAS28. The number of painful regions in the body and ESR, CRP, RF and ACPA were analyzed. TMJ synovial fluid and blood samples were obtained and analyzed for TNF, TNFsRII, IL-1ra, IL-1sRII and ACPA. The ratios between the mediators and their endogenous control receptors were used in the statistical analysis. Magnetic resonance imaging was performed in closed- and open-mouth positions and evaluated regarding disc position and presence of condylar and temporal erosions of the TMJ. Results. A high TNF level in relation to TNFsRII in TMJ synovial fluid correlated to the degree of TMJ condylar erosion. A high IL-1ra level in relation to TNF in TMJ synovial fluid was also correlated to the degree of TMJ condylar erosion. The total degree of TMJ condylar erosion was correlated with the number of painful regions. Conclusion. This study indicates that TNF in TMJ synovial fluid mediates TMJ cartilage and bone tissue resorption in RA. The study also suggests that the degree of endogenous cytokine control is of importance for development of bone tissue destruction. PMID:25515682

Ahmed, Neveen; Petersson, Arne; Catrina, Anca Irinel; Mustafa, Hamid; Alstergren, Per

2015-04-01

396

Effects of Neuropeptides and Mechanical Loading on Bone Cell Resorption in Vitro  

Directory of Open Access Journals (Sweden)

Full Text Available Neuropeptides such as vasoactive intestinal peptide (VIP and calcitonin gene-related peptide (CGRP are present in nerve fibers of bone tissues and have been suggested to potentially regulate bone remodeling. Oscillatory fluid flow (OFF-induced shear stress is a potent signal in mechanotransduction that is capable of regulating both anabolic and catabolic bone remodeling. However, the interaction between neuropeptides and mechanical induction in bone remodeling is poorly understood. In this study, we attempted to quantify the effects of combined neuropeptides and mechanical stimuli on mRNA and protein expression related to bone resorption. Neuropeptides (VIP or CGRP and/or OFF-induced shear stress were applied to MC3T3-E1 pre-osteoblastic cells and changes in receptor activator of nuclear factor kappa B (NF-?B ligand (RANKL and osteoprotegerin (OPG mRNA and protein levels were quantified. Neuropeptides and OFF-induced shear stress similarly decreased RANKL and increased OPG levels compared to control. Changes were not further enhanced with combined neuropeptides and OFF-induced shear stress. These results suggest that neuropeptides CGRP and VIP have an important role in suppressing bone resorptive activities through RANKL/OPG pathway, similar to mechanical loading.

Yeong-Min Yoo

2014-04-01

397

Resorption of the element zinc from spermatozoa by the epididymal epithelium.  

Science.gov (United States)

In this study, elimination of the element zinc from spermatozoa during epididymal maturation was investigated. Testes and epididymides from 40 bulls were collected; epididymal fluid was flushed, pooled, labelled with 0.5 MBq 65Zn2+ per sample and proteins were separated on a Sephacryl S-200 HR and zinc chelate column chromatography. To follow the resorption of zinc in the epididymal epithelial lining, an autometallographic technique (AMG) was performed in tissue from caput, corpus, cauda and vas deferens. The results showed a zinc-binding protein fraction with an apparent molecular weight of 150-160 kDa, which was enriched after chelate column chromatography. Specific labelling of 65Zn was about five times higher in the caput than in the cauda epididymidis. AMG revealed no detectable zinc in the caput, but a significant increase of zinc resorption from the corpus to the cauda and vas deferens. Controls showed that the detectable zinc was located within the principal cells. In conclusion, our study proves that zinc present in the sperm flagellum starts to be mobilized in the caput epididymidis and is resorbed by the epididymal epithelium as from the corpus. This zinc elimination is a mandatory step in sperm maturation to obtain motility. PMID:12654019

Henkel, R; Baldauf, C; Schill, W-B

2003-04-01

398

Various selected vegetables, fruits, mushrooms and red wine residue inhibit bone resorption in rats.  

Science.gov (United States)

To make a broad survey of the effect of components of the human diet on bone resorption, a few items from the following categories were added to rat diets: vegetables, fruits, beans, nuts and seeds, mushrooms, carbohydrate sources and beverages. The effect on bone resorption was measured by the urinary excretion of tritium released from bones of 9-wk-old rats prelabeled with tritiated tetracycline from weeks 1 to 6. The number of rats per experiment was 26--6, 5, 5, 5 and 5 in the untreated control group fed the plain semipurified diet, the positive control group fed onions and three groups fed one of the newly investigated items, respectively. New experiments were added until 10 rats were fed each item in each of two separate experiments. The results for each item were compared to those for the untreated control group (n = 12) investigated simultaneously. We found that feeding rats 1 g/d of dry fennel, celeriac, oranges, prunes, French beans and farmed and wild mushrooms (Agaricus hortensis and Boletus edulis) as well as the freeze-dried residue from red wine significantly (P mushrooms, fruits and red wine residue (25/36 items effective). Furthermore, as assessed in a similar experimental design with various doses of a mixture of active items, we determined the minimum effective dose of the dry items to be 170 mg/d. These results open the possibility for targeted interventions in humans. PMID:14608079

Mühlbauer, Roman C; Lozano, Annemarie; Reinli, Andreas; Wetli, Herbert

2003-11-01

399

Study on bone resorption behavior of osteoclast under drug effect using {sup 41}Ca tracing  

Energy Technology Data Exchange (ETDEWEB)

The mechanisms governing calcium fluxes during bone remodeling processes in Osteoporosis (OP) patients are poorly known. Understanding the changes of Osteoclasts (OC) during this dynamic transition is important to prevent and cure OP. The exploration of long-lived {sup 41}Ca (T{sub 1/2} = 1.04 Multiplication-Sign 10{sup 5} years) tracer combined with AMS measurements leads to the possibility of monitoring the bone resorption behavior of OC in OP patients. In this work, the behavior of OC with the administration of Strontium Ranelate (SR), a drug for OP, was studied by using {sup 41}Ca labeled hydroxyapatite (HAP) to simulate the bone. AMS on the HI-13 tandem accelerator at CIAE was used to determine trace amounts of {sup 41}Ca. The results show that the technique of {sup 41}Ca tracing with AMS can be used to quantitatively monitor the behavior of OC in bone resorption under the effects of drugs. Experimental details and preliminary results will be presented.

Dong Kejun [China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413 (China); Lu Liyan [China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413 (China); CNNC Third Qinshan Nuclear Power Co. Ltd., Haiyan 314300 (China); He Ming; Ouyang Yinggen; Xue Yan; Li Chaoli; Wu Shaoyong [China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413 (China); Wang Xianggao [College of Physics Science and Technology, Guangxi University, Nanning 530004 (China); Shen Hongtao [College of Physics and Technology, Guangxi Normal University, Guilin 541004 (China); Gao Jianjun [Institute of Radiation Medicine, Fudan University, Shanghai 200032 (China); Wang Wei [China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413 (China); China National Nuclear Corporation, Beijing 100822 (China); Chen Dafu; Xing Yonggang [Beijing Research Institute of Traumatology and Orthopaedics, Beijing 100035 (China); Jian, Yuan [China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413 (China); Jiang Shan, E-mail: jiangs@ciae.ac.cn [China Institute of Atomic Energy, P.O. Box 275(50), Beijing 102413 (China)

2013-01-15

400

Marker of Bone Resorption in Acute Response to Exogenous or Endogenous Parathyroid Hormone  

Directory of Open Access Journals (Sweden)

Full Text Available Parathyroid hormone (PTH changes morphology of osteoclasts within minutes after its systemic administration. The aim of our study was to test in healthy men whether both exogenous and endogenous PTH could change acutely (minutes to hours the serum cross-linked C-telopeptide of type I collagen (beta CTX, which is released during osteoclastic resorption of bone. Twelve healthy men (age range 24–34 yr were each studied during 180 min on a control period, after a single subcutaneous injection of teriparatide, and after 30 min EDTA infusion to stimulate endogenous PTH secretion. The tests were started after overnight fast, 3 h after a standard calcium load. The EDTA infusion induced a significant decrease in serum ionized calcium (by 8.5% at 33 min and a significant increase in plasma PTH (by 305% at 33 min. Both the EDTA and teriparatide resulted in a significant increase in beta CTX (p < 0.001 with maximum increases of 64% and 80%, respectively. A mild, but significant decrease in beta CTX was observed during the control test period. In conclusion, single-dose teriparatide injection as well as a stimulation of endogenous PTH in healthy men results in an acute increase of the bone resorption marker.

Vit Zikan

2008-01-01

401

Plasma Serotonin and Markers of Bone Formation and Bone Resorption in Hemodialysis Patients  

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Full Text Available Introduction. Serotonin receptors are present in osteoblasts and osteoclasts, and serotonin affects bone metabolism. The association of plasma serotonin with markers of bone formation and bone resorption in hemodialysis patients was evaluated. Materials and Methods. Twenty-four hemodialysis patients (11 diabetics and 22 healthy volunteers were enrolled into the study. Serotonin was assessed in platelet-free plasma, whereas the markers of osteoblastic activity N-terminal midfragment osteocalcin and total procollagen type-1 aminoterminal propeptide as well as the marker of osteoclastic activity ?-isomerized C-terminal cross-linked peptide of collagen type I were measured in serum. Serum intact parathyroid hormone was also assessed. Results. Serotonin did not significantly differ between hemodialysis patients and healthy volunteers. All evaluated markers of bone metabolism and intact parathyroid hormone were much higher in hemodialysis patients. Serotonin was significantly correlated with all evaluated markers of bone metabolism in hemodialysis patients. Serotonin was reversely related to the patients' age. Serotonin, osteocalcin, procollagen type-1 aminoterminal propeptide, and ?-isomerized C-terminal cross-linked peptide of collagen type I were much lower in diabetic hemodialysis patients. Conclusions. Serotonin may increase both bone formation and bone resorption in hemodialysis patients. The reverse relation of serotonin to patients' age as well as its lower levels in diabetic hemodialysis patients indicate that low plasma serotonin may contribute to the higher incidence of low-turnover bone disease that characterizes old and diabetic hemodialysis patients.

Theodoros Eleftheriadis

2013-01-01

402

Comparison of the changes of alveolar bone thickness in maxillary incisor area in extraction and non-extraction cases: computerized tomography evaluation  

Scientific Electronic Library Online (English)

Full Text Available SciELO Brazil | Language: English Abstract in portuguese OBJETIVO: comparar, por meio de tomografia computadorizada, a alteração da espessura óssea alveolar na região de incisivos superiores durante o tratamento ortodôntico, com e sem extração dentária. MÉTODOS: foram avaliados 12 pacientes, divididos em dois grupos: G1, seis pacientes tratados com extraç [...] ões de dois primeiros pré-molares superiores, com idade média inicial de 15,83 anos, e tratados por um tempo médio de 2,53 anos; G2, seis pacientes tratados sem extrações, com idade média inicial de 18,26 anos e tratados por um período de 2,39 anos. Foram utilizadas tomografias computadorizadas, telerradiografias em norma lateral e radiografias periapicais ao início (T1) e após 18 meses de tratamento (T2), desde que o espaço da extração já estivesse fechado nos casos tratados com extrações. A comparação intragrupo foi realizada por meio do teste t dependente, e a comparação intergrupos por meio do com o teste t independente. RESULTADOS: o grupo 1 apresentou uma retração e verticalização do incisivo central, enquanto o grupo 2 apresentou uma vestibularização desse dente. Além disso, o grupo 1 apresentou maior aumento da espessura óssea cervical vestibular durante o tratamento, quando comparado ao grupo 2. A incidência de reabsorção radicular não apresentou diferenças significativas entre os grupos. CONCLUSÕES: não houve alteração nas espessuras ósseas alveolares quando comparados casos tratados com e sem extrações, com exceção da espessura óssea vestibular na região cervical dos incisivos superiores. Abstract in english OBJECTIVE: To compare, through computed tomography, alveolar bone thickness changes at the maxillary incisors area during orthodontic treatment with and without tooth extraction. METHODS: Twelve patients were evaluated. They were divided into 2 groups: G1 - 6 patients treated with extraction of righ [...] t and left maxillary first premolars, with mean initial age of 15.83 years and mean treatment length of 2.53 years; G2 - 6 patients treated without extraction, with mean initial age of 18.26 years and mean treatment length of 2.39 years. Computed tomographies, lateral cephalograms and periapical radiographs were used at the beginning of the treatment (T1) and 18 months after the treatment had started (T2). Extraction space closure occurred in the extraction cases. Intragroup and intergroup comparisons were performed by dependent and independent t test, respectively. RESULTS: In G1, the central incisor was retracted and uprighted, while in G2 this tooth showed vestibularization. Additionally, G1 presented a higher increase of labial alveolar bone thickness at the cervical third in comparison with G2. The incidence of root resorption did not present significant differences between groups. CONCLUSION: There were no changes in alveolar bone thickness when extraction and nonextraction cases were compared, except for the labial alveolar bone thickness at the cervical third of maxillary incisors.

Paulo Roberto Barroso, Picanço; Fabricio Pinelli, Valarelli; Rodrigo Hermont, Cançado; Karina Maria Salvatore de, Freitas; Gracemia Vasconcelos, Picanço.

2013-10-01

403

Prevalent of root resorption of second molar adjustment the impacted third molar in prepiacal and panoramic radiographs  

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Full Text Available   Background and Aims: Impacted third molar reduces the bone level in the distal aspect of second molar, and sometimes it can lead to root resorption of the adjacent tooth. The purpose of this study was to determine this resorption using panoramic and periapical radiographs.   Materials and Methods: In this cross-sectional descriptive study 54 patient (28 men, 26 women above 15 years old with the average of 22 years in Oral and Maxillofacial Department of Tehran University were studied. A periapical radiography from the third molar and a panoramic radiograph were taken from each patient (Because of their routine use and evaluation of accuracy of panoramic compared with periapical, and the magnitude of the root resorption for the second molar was determined by 2 observers and written in a questionnaire. Data were analyzed using Fisher test.   Results: The prevalence of the root resorption of the second molar adjacent to the impacted third molar in the panoramic and the periapical radiographies, with respect to the limitation of the sample size were 46.3% and 31.5%, respectively, with 95% confidence(P>0.05. Most of these resorptions were in the cervical third of the second molar roots and in cases in which the third molars were mesially oriented or horizontal. There was also no significant difference between panoramic and periapical radiographs.   Conclusion: Due to the increased risk of the resorption of the second molar adjacent to the third molar, extraction of the impacted third molars, especiall y mesially oriented or horizontal ones are recommended.

Mohammad Ebrahimi Saravi

2013-10-01

404

Bone resorption is decreased postprandially by intestinal factors and glucagon-like peptide-2 is a possible candidate  

DEFF Research Database (Denmark)

OBJECTIVE: Food intake inhibits bone resorption by a mechanism thought to involve gut hormones, and the intestinotrophic glucagon-like peptide 2 (GLP-2) is a candidate because exogenous GLP-2 inhibits bone resorption in humans. The purpose of the study was to investigate patients with short-bowel syndrome (SBS) or total gastrectomy in order to elucidate whether the signal for the meal-induced reduction of bone resorption is initiated from the stomach or the intestine. MATERIAL AND METHODS: Bone resorption was assessed from the serum concentration of collagen type I C-telopeptide cross-links (s-CTX) and compared with the plasma concentrations of GLP-2. Bone formation was assessed from serum osteocalcin concentrations. Seven SBS patients with a preserved colon and 7 with SBS and colectomy and 7 healthy controls were given a breakfast test meal (936 kcal). Eight patients who had undergone total gastrectomy had an oral glucose load (75 g in 150 ml). RESULTS: The SBS patients without a colon showed no reduction in bone resorption (s-CTX) to a meal, whereas SBS patients with a colon had an intermediate response with a 27% (p<0.05) reduction of s-CTX from baseline after 120 min as compared with 66% (p<0.001) for normal controls. A significant reduction of 53% (p<0.001) was seen in gastrectomized patients after receiving oral glucose, which is comparable with the published data for the oral glucose tolerance test (OGGT) in healthy subjects (50% reduction over 120 min). Bone formation was unchanged for both SBS and gastrectomy patients. GLP-2 concentrations increased significantly in all groups with the exception of the SBS plus colectomy group. CONCLUSIONS: An intestinal factor is responsible for the postprandial reduction in bone resorption, and our findings are compatible with such a function for GLP-2.

Holst, Jens Juul; Hartmann, Bolette

2007-01-01

405

Fresh-frozen bone allografts in maxillary ridge augmentation: histologic analysis.  

Science.gov (United States)

Bone allograft has become an alternative to autogenous bone due to its decreased operative trauma and the almost unlimited supply of reconstructive material. The aim of the present study was to histologically evaluate the suitability of fresh-frozen bone graft (test group) used in maxillary ridge augmentation, comparing it to autogenous bone (native maxilla: control group). During the re-entry procedures, 9 months after the fresh-frozen allogeneic bone blocks were placed in the atrophic maxillary