WorldWideScience
 
 
1

Endosseous alveolar distractor (LEAD™) in the management of residual alveolar ridge resorption.  

UK PubMed Central (United Kingdom)

BACKGROUND: Lack of sufficient alveolar bone height or width is one of the most frequent problems in the dental rehabilitation of the edentulous patient. METHODS: A prospective study to evaluate the efficacy of an endosseous alveolar distractor (LEADTM) in managing residual alveolar ridge resorption was carried out. The complications related to the surgical procedure and the quantitative changes in the regenerate over a 6 month period following distraction were studied in 13 cases with alveolar ridge atrophy. RESULT: Desired ridge augmentation was achieved in 11 cases. In 2 cases the distraction failed. Some unusual complications were encountered. CONCLUSION: The LEAD™ alveolar distractor produces consistent augmentation of the alveolar bone but is confronted with stability issues.

Sudeep S; Thapliyal GK; Suresh Menon P; Sinha R

2009-12-01

2

Effects of smoking on resorption of the residual alveolar ridges in complete denture wearers  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction Based on literature data it is obvious that there is a connection between smoking and periodontal diseases. Alveolar bone loss increases with smoking. Tobacco smoking affects the proportion of subgingival bacterial flora by influencing oxidoreduction potential of dental plaque and thus making conditions for development of anaerobic bacteria. According to some researchers, smoking affects the mineral component of bone tissue. Orthopantomograms show higher level of alveolar bone loss in smokers than in nonsmokers with the same level of oral hygiene. The aim of this study was to establish if smoking affects alveolar bone loss in complete denture wearers. Material and methods Our clinical investigation included 60 patients of both sexes (30 smokers and 30 nonsmokers) all complete dentures wearers. All patients met study criteria: jaw relation and smokers who smoke over 20 cigarettes per day. All subjects were interviewed, and after that orthopantomograms were made. They were used to calculate the degree of alveolar bone loss. Results The examined subjects were approximately of the same age. Mean age of smokers was 59.9 and nonsmokers 61.8. It was established that differences regarding resorption in men were not significant. The degree of resorption in women smokers and women nonsmokers was different, but differences were not significant. Discussion It has been proven that the number of cigarettes smoked per day is very important. It is considered that the risk of oral epithelial dysplasia increases when smoking more than 20 cigarettes per day. Considering our results regarding resorption of edentulous alveolar ridge in smokers and nonsmokers, we concluded that there were no significant differences. There are opinions in literature that smoking is not an etiological factor in resorption, but there are some opinions that smoking is connected with the degree of resorption in periodontium. The analyses of resorptive changes in edentulous smokers were done only around implants and it was estimated that smoking has more influence than other clinical risk factors. Conclusion On the bases of our research we may conclude that smoking does not directly affect the degree of resorption of edentulous alveolar ridge with complete denture wearers.

Markovi? Dubravka; Jefi? Bojana; Blagojevi? Duška; Blaži? Larisa

2003-01-01

3

Alveolar ridge resorption after tooth extraction: A consequence of a fundamental principle of bone physiology  

Directory of Open Access Journals (Sweden)

Full Text Available It is well established that tooth extraction is followed by a reduction of the buccolingual as well as the apicocoronal dimension of the alveolar ridge. Different measures have been taken to avoid this bone modelling process, such as immediate implant placement and bone grafting, but in most cases with disappointing results. One fundamental principle of bone physiology is the adaptation of bone mass and bone structure to the levels and frequencies of strain. In the present article, it is shown that the reduction of the alveolar ridge dimensions after tooth extraction is a natural consequence of this physiological principle.

Stig Hansson; Anders Halldin

2012-01-01

4

[Implant therapy following trauma of the anterior teeth – a new method for alveolar ridge preservation after post-traumatic ankylosis and external root resorption].  

UK PubMed Central (United Kingdom)

The therapy of traumatized front teeth with ankylosis and additional root resorption is a real challenge for the clinician. Due to the infraposition ankylosed teeth are useless and esthetically unsatisfactory. The progressive replacement resorption and the vertical growth inhibition render an intervention inevitable. In the following case report, the prophylaxis of the alveolar ridge is brought into focus. The treatment of two ankylosed teeth by decoronation, preservation of the alveolar ridge and an implant-supported supraconstruction will be presented. The additional histological assessment confirms the diagnosis and the choice of treatment.

Scheuber S; Bosshardt D; Brägger U; von Arx T

2013-01-01

5

Degree of the residual alveolar ridge resorption registrated by ortopantomograms among immediate and classic complete denture users  

Directory of Open Access Journals (Sweden)

Full Text Available Degree of residual ridge loss is influenced by sistemic phactors, but during the first phase after extraction local phactors are dominant. Patohistological changes of alveolar processus of jaws show the possibility of negative influence of complete dentures on support tissue. In this study, on the chosen sample, the degree of alveolar ridge loss was measured in the group of immediate complete denture users (30 patients) and classical complete denture users ( 30 patients).Height of residual alveolar ridge was measured on ortopantomograms. Localization of referent points proportion was used because of neutralization of shadow distorsion (five in maxilla and five in mandibula). The first ortopantomogram was made at the time of delivering dentures, and the second one six months later. The final measurement of alveolar ridge height is bigger in the group with classical dentures. The reduction degree of residual alveolar ridge is bigger in the group of immediate complete denture users in the first six months.

Markovi? Dubravka; Krsti? Mirjana 1; ?uri? Milanko; Brkani? Tatjana

2002-01-01

6

Effect of smoking on alveolar bone resorption  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Periodontal disease is one of the most common diseases in adults. Although the cause of periodontal disease is bacterial infection from the dental plaque, the level of destruction of periodontal tissues depends on risk factors, and smoking is one of the most important ones. Aim: The aim of the present study was to determine the level of alveolar bone resorption in smokers. Materials and Methods: Radiographic examination of all present teeth was conducted in 30 smokers (12 men and 18 women) and 30 non-smokers (13 men and 17 women, control group), 20-60 years of age. Data on smoking habits, smoking period and the number of cigarettes a day were obtained using a questionnaire. The level of alveolar bone resorption was determined on retroalveolar X-rays, by measuring the distance from the amelo-cemental junction to the bone level on mesial and distal sides of each present tooth. Results: In smokers, significantly higher (p=0.00002) values of alveolar bone resorption (3.16 ± 2.07 mm) were found compared to the control group (1.72 ± 1.02 mm). In people who had been smoking for more than 15 years, significantly greater bone resorption was observed compared to those smoking for 15 years or less (p=0.00028). The interceptive relationship showed that smokers were at 2.98x greater risk (95% CI 1.04- 8.52) for the mean value of alveolar bone resorption of > 2 mm compared to non-smokers. Conclusion: The present results have shown that smoking increases alveolar bone resorption and that the period of smoking affects the level of resorption.

Ra?unica Jelena; Iveti? Vesna; Naumovi? Nada; ?uri? Milanko

2008-01-01

7

Alveolar ridge preservation. A systematic review.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective of this paper is to examine the effect of alveolar ridge preservation (ARP) compared to unassisted socket healing. METHODS: Systematic review with electronic and hand search was performed. Randomised controlled trials (RCT), controlled clinical trials (CCT) and prospective cohort studies were eligible. RESULTS: Eight RCTs and six CCTs were identified. Clinical heterogeneity did not allow for meta-analysis. Average change in clinical alveolar ridge (AR) width varied between -1.0 and -3.5 ± 2.7 mm in ARP groups and between -2.5 and -4.6 ± 0.3 mm in the controls, resulting in statistically significantly smaller reduction in the ARP groups in five out of seven studies. Mean change in clinical AR height varied between +1.3 ± 2.0 and -0.7 ± 1.4 mm in the ARP groups and between -0.8 ± 1.6 and -3.6 ± 1.5 mm in the controls. Height reduction in the ARP groups was statistically significantly less in six out of eight studies. Histological analysis indicated various degrees of new bone formation in both groups. Some graft interfered with the healing. Two out of eight studies reported statistically significantly more trabecular bone formation in the ARP group. No superiority of one technique for ARP could be identified; however, in certain cases guided bone regeneration was most effective. Statistically, significantly less augmentation at implant placement was needed in the ARP group in three out of four studies. The strength of evidence was moderate to low. CONCLUSIONS: Post-extraction resorption of the AR might be limited, but cannot be eliminated by ARP, which at histological level does not always promote new bone formation. RCTs with unassisted socket healing and implant placement in the ARP studies are needed to support clinical decision making. CLINICAL RELEVANCE: This systematic review reports not only on the clinical and radiographic outcomes, but also evaluates the histological appearance of the socket, along with site specific factors, patient-reported outcomes, feasibility of implant placement and strength of evidence, which will facilitate the decision making process in the clinical practice.

Horváth A; Mardas N; Mezzomo LA; Needleman IG; Donos N

2013-03-01

8

Bioactive glass for alveolar ridge augmentation.  

UK PubMed Central (United Kingdom)

The restoration and recovery of the alveolar healing process are a challenge to dental surgeons to achieve satisfactory results at the osseointegration of implants and implant rehabilitation. Different operative technique and biomaterials are being used to reconstruct the framework of the alveolar process. One of the biomaterials used for this purpose is the bioactive glass. The aim of this study was to report clinical and histologic final results of 7 clinical reports of alveolar ridge augmentation using bioactive glass. Clinically, bioglass was able to maintain bone architecture of the alveolar bone and repaired satisfactory. Biopsy was performed on the histologic samples and showed bone formation in intimate contact to the particles of the biomaterial.

Margonar R; Queiroz TP; Luvizuto ER; Marcantonio É; Lia RC; Holzhausen M; Marcantonio-Júnior É

2012-05-01

9

A review on alveolar ridge preservation following tooth extraction.  

UK PubMed Central (United Kingdom)

CONTEXT: The question that clinicians face is whether the use of bone replacement grafts and/or barrier membranes enhance their ability to provide for the future placement of a dental implant or to maximize ridge dimensions following the extraction of a tooth versus no additional treatments. EVIDENCE ACQUISITION: The evidence was obtained by search of Entrez PubMed and manual search of The International Journal of Oral and Maxillofacial Implants, The International Journal of Periodontics & Restorative Dentistry, Clinical Oral Implant Research, The Journal of Periodontology, The Journal of Clinical Periodontology, and The Compendium of Continuing Education in Dentistry. Key search words included Guided Bone Regeneration, Dental Extraction, Tooth Extraction, Bone Replacement Graft, Alveolar Ridge. The years of search included from January 2011 through February 2012. EVIDENCE SYNTHESIS: The recurring theme was that there was considerable heterogeneity to study designs, time periods, and methods of evaluation. This created great difficulty in trying to answer with good high-quality evidence questions about the techniques and materials to be used for maximizing regeneration at the time of tooth extraction or in which situations this ought to be used. CONCLUSIONS: There appears to be consensus from the reviewed literature supporting ridge preservation techniques as a whole. Multiple studies demonstrated less ridge resorption occurring when alveolar ridge preservation procedures were used versus the placement of no graft material in fresh alveolar sockets. The analysis did not show any grafting materials demonstrating a clear benefit over any others or that a barrier membrane is necessary. The evidence is also too premature about whether socket preservation efforts require primary closure. In the emerging area of growth factors, there is no high-quality evidence to either support or refute their use. BACKGROUND: Tooth extraction is one of the most widely performed procedures in dentistry today and it has been historically well documented that this procedure may induce significant dimensional changes of the alveolar ridge. The dilemma that clinicians face is how to manage tooth extractions to provide for the future placement of a dental implant or to maximize ridge dimensions for the fabrication of a fixed or removable prosthesis. If performed inadequately, the resulting deformity can be a considerable obstacle to the esthetic, phonetic, and functional results that both our patients and we clinicians expect at this current time.

Horowitz R; Holtzclaw D; Rosen PS

2012-09-01

10

Modern therapy for severe alveolar ridge atrophy.  

UK PubMed Central (United Kingdom)

This clinical report illustrates a modern method for oral rehabilitation of severe edentulous atrophic ridge. Shallow vestibule and small denture-bearing area of the maxilla provide insufficient retention, and only the symphyseal region of the mandible has obvious alveolar ridge. The surgery of deepening vestibule of the maxilla ridge was done by using tentative miniscrew combined with old denture and soft liner. The osseointegrated dental implants were installed over symphyseal region of the mandible to act as retentive devices for prostheses. In addition, functional reline with rebase material to build buccal-tongue contact over the retromolar area after denture delivery obtained high satisfaction from the patient. Many clinical conditions cannot be managed solely with implants or preprosthetic surgery alone, whereas a combination of the 2 can achieve successful outcome.

Chen YF; Pan CY; Wang WC; Lan TH

2013-09-01

11

Reactive dentures: a novel approach to decrease residual ridge resorption.  

UK PubMed Central (United Kingdom)

The need for reduction of traumatic forces transmitted through the prosthesis has long been recognised and studies have shown that either a soft acrylic resin/silicone rubber can serve as a stress distributor and absorb some of the forces applied to the teeth. These dentures permit reaction to impacting forces which allows independent movement of one or more teeth in function unlike the conventional dentures. A completely edentulous patient with adequate inter-ridge distance was selected for the case, the dentures with soft liner placed between the patient's teeth and denture base were fabricated. This report presents a completely new technique to reduce the ridge resorption and facilitate patient comfort.

Reddy KK; Prasanna RG; Sundaresh KJ; Mallikarjuna R

2013-01-01

12

In vivo microcomputed tomography evaluation of rat alveolar bone and root resorption during orthodontic tooth movement.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To observe the real-time microarchitecture changes of the alveolar bone and root resorption during orthodontic treatment. Materials and METHODS: A 10 g force was delivered to move the maxillary left first molars mesially in twenty 10-week-old rats for 14 days. The first molar and adjacent alveolar bone were scanned using in vivo microcomputed tomography at the following time points: days 0, 3, 7, and 14. Microarchitecture parameters, including bone volume fraction, structure model index, trabecular thickness, trabecular number, and trabecular separation of alveolar bone, were measured on the compression and tension side. The total root volume was measured, and the resorption crater volume at each time point was calculated. Univariate repeated measures analysis of variance with Bonferroni corrections were performed to compare the differences in each parameter between time points with significance level at P < .05. RESULTS: From day 3 to day 7, bone volume fraction, structure model index, trabecular thickness, and trabecular separation decreased significantly on the compression side, but the same parameters increased significantly on the tension side from day 7 to day 14. Root resorption volume of the mesial root increased significantly on day 7 of orthodontic loading. CONCLUSIONS: Real-time root and bone resorption during orthodontic movement can be observed in 3 dimensions using in vivo micro-CT. Alveolar bone resorption and root resorption were observed mostly in the apical third on day 7 on the compression side; bone formation was observed on day 14 on the tension side during orthodontic tooth movement.

Ru N; Liu SS; Zhuang L; Li S; Bai Y

2013-05-01

13

Management of Compromised Vertical Alveolar Ridge using Distraction Osteogenesis  

Directory of Open Access Journals (Sweden)

Full Text Available Deficient alveolar ridge is an often encountered problem which causes problem in providing prosthesis to patients. Acquired alveolar deficiencies are the result of tooth loss and associated periodontal disease, trauma or other pathology. This case report describes vertical mandibular alveolar ridge distraction achieved using Liebenger endosseous alveolar distractor device in a patient who had vertical ridge defect due to localized aggressive periodontitis leading to tooth loss. Total 5.6mm vertical distraction in mandibular alveolar ridge was achieved at 0.8mm per day in eight days. The advantage of this technique is that there is no need for bone harvesting hence it is not associated with donor site morbidity. Moreover gain of both soft tissue along with hard tissue is achieved.

Wg Cdr Parul Sharma; Col. SK Rath; Lt. Col. Mukherjee

2011-01-01

14

Reactive dentures: a novel approach to decrease residual ridge resorption.  

Science.gov (United States)

The need for reduction of traumatic forces transmitted through the prosthesis has long been recognised and studies have shown that either a soft acrylic resin/silicone rubber can serve as a stress distributor and absorb some of the forces applied to the teeth. These dentures permit reaction to impacting forces which allows independent movement of one or more teeth in function unlike the conventional dentures. A completely edentulous patient with adequate inter-ridge distance was selected for the case, the dentures with soft liner placed between the patient's teeth and denture base were fabricated. This report presents a completely new technique to reduce the ridge resorption and facilitate patient comfort. PMID:23576651

Reddy, Kesava K; Prasanna, Renuka G S; Sundaresh, K J; Mallikarjuna, Rachappa

2013-04-09

15

Distracción osteogénica alveolar como método de aumento del reborde alveolar Alveolar osteogenic distraction as method to increase the alveolar ridge  

Directory of Open Access Journals (Sweden)

Full Text Available La distracción osteogénica alveolar, como proceso biológico de neoformación de hueso alveolar, nos motivó a la realización de la presente revisión bibliográfica, con el objetivo enfatizar en el análisis de las variables: antecedentes históricos en Cuba, clasificación de los distractores, fases de la distracción (latencia, distracción y consolidación), indicaciones, contraindicaciones, ventajas, desventajas y complicaciones. Se realizó una revisión bibliográfica mediante la consulta de bases de datos de los sistemas referativos, como MEDLINE y PubMed con la utilización de descriptores "alveolar distraction" y "osteogenic distraction". Se consultaron las fuentes bibliográficas publicadas fundamentalmente en los últimos 5 años, lo que reveló que esta técnica es una excelente alternativa para la formación de huesos y tejidos blandos en zonas de atrofia alveolar, que consta de tres etapas: latencia, distracción y consolidación; un método previsible y con bajas tasas de reabsorción ósea en comparación con otras técnicas de aumento del reborde alveolar. Tiene su principal indicación en la terapia de implantes al proveer volumen óseo. Debemos individualizar cada caso y usar el método más adecuado según las características clínicas y personales del paciente. Una adecuada selección de los casos y una mejor comprensión de la técnica son los puntales para lograr exitosos resultados mediante la distracción osteogénica alveolar. En Cuba se ha aplicado poco la distracción alveolar, por lo que ha sido necesario ampliar los estudios sobre esta temática.The alveolar osteogenic distraction, as a biological process of alveolar bone neoformation, motivates us to make the bibliographic review whose objective was to emphasize in analysis the following variables: historical backgrounds in Cuba, distraction classification, distraction phases (latency, distraction and consolidation), indications, contraindications, advantages, disadvantages and complications. A bibliographic review was made by database search of reference systems as MEDLINE and PubliMed using the descriptors "alveolar distraction" o "osteogenic distraction". The published bibliographic sources mainly over 5 years concluding that this technique is an excellent alternative for the bone and soft tissues formation in zones of alveolar atrophy including three stages: latency, distraction and consolidation; being a foreseeable method and with low rates of bone reabsorption compared to other techniques of increase of alveolar ridge. It has its main indication in implant therapy to provide bone volume. We must to individualize each case and to use the more appropriate method according the clinical and personal features of patient. A proper case selection and a better understand of technique are essential to achieve successful results by alveolar osteogenic distraction. In Cuba the alveolar distraction has been not much applied being necessary to expand the studies on this subject matter.

Denia Morales Navarro

2011-01-01

16

Distracción osteogénica alveolar como método de aumento del reborde alveolar/ Alveolar osteogenic distraction as method to increase the alveolar ridge  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish La distracción osteogénica alveolar, como proceso biológico de neoformación de hueso alveolar, nos motivó a la realización de la presente revisión bibliográfica, con el objetivo enfatizar en el análisis de las variables: antecedentes históricos en Cuba, clasificación de los distractores, fases de la distracción (latencia, distracción y consolidación), indicaciones, contraindicaciones, ventajas, desventajas y complicaciones. Se realizó una revisión bibliogr (more) áfica mediante la consulta de bases de datos de los sistemas referativos, como MEDLINE y PubMed con la utilización de descriptores "alveolar distraction" y "osteogenic distraction". Se consultaron las fuentes bibliográficas publicadas fundamentalmente en los últimos 5 años, lo que reveló que esta técnica es una excelente alternativa para la formación de huesos y tejidos blandos en zonas de atrofia alveolar, que consta de tres etapas: latencia, distracción y consolidación; un método previsible y con bajas tasas de reabsorción ósea en comparación con otras técnicas de aumento del reborde alveolar. Tiene su principal indicación en la terapia de implantes al proveer volumen óseo. Debemos individualizar cada caso y usar el método más adecuado según las características clínicas y personales del paciente. Una adecuada selección de los casos y una mejor comprensión de la técnica son los puntales para lograr exitosos resultados mediante la distracción osteogénica alveolar. En Cuba se ha aplicado poco la distracción alveolar, por lo que ha sido necesario ampliar los estudios sobre esta temática. Abstract in english The alveolar osteogenic distraction, as a biological process of alveolar bone neoformation, motivates us to make the bibliographic review whose objective was to emphasize in analysis the following variables: historical backgrounds in Cuba, distraction classification, distraction phases (latency, distraction and consolidation), indications, contraindications, advantages, disadvantages and complications. A bibliographic review was made by database search of reference system (more) s as MEDLINE and PubliMed using the descriptors "alveolar distraction" o "osteogenic distraction". The published bibliographic sources mainly over 5 years concluding that this technique is an excellent alternative for the bone and soft tissues formation in zones of alveolar atrophy including three stages: latency, distraction and consolidation; being a foreseeable method and with low rates of bone reabsorption compared to other techniques of increase of alveolar ridge. It has its main indication in implant therapy to provide bone volume. We must to individualize each case and to use the more appropriate method according the clinical and personal features of patient. A proper case selection and a better understand of technique are essential to achieve successful results by alveolar osteogenic distraction. In Cuba the alveolar distraction has been not much applied being necessary to expand the studies on this subject matter.

Morales Navarro, Denia

2011-03-01

17

Quantification and visualization of alveolar bone resorption from 3D dental CT images  

International Nuclear Information System (INIS)

Purpose A computer aided diagnosis (CAD) system for quantifying and visualizing alveolar bone resorption caused by periodontitis was developed based on three-dimensional (3D) image processing of dental CT images. Methods The proposed system enables visualization and quantification of resorption of alveolar bone surrounding and between the roots of teeth. It has the following functions: (1) vertical measurement of the depth of resorption surrounding the tooth in 3D images, avoiding physical obstruction; (2) quantification of the amount of resorption in the furcation area; and (3) visualization of quantification results by pseudo-color maps, graphs, and motion pictures. The resorption measurement accuracy in the area surrounding teeth was evaluated by comparing with dentist's recognition on five real patient CT images, giving average absolute difference of 0.87 mm. An artificial image with mathematical truth was also used for measurement evaluation. Results The average absolute difference was 0.36 and 0.10 mm for surrounding and furcation areas, respectively. The system provides an intuitive presentation of the measurement results. Conclusion Computer aided diagnosis of 3D dental CT scans is feasible and the technique is a promising new tool for the quantitative evaluation of periodontal bone loss. (orig.)

2007-01-01

18

Quantification and visualization of alveolar bone resorption from 3D dental CT images  

Energy Technology Data Exchange (ETDEWEB)

Purpose A computer aided diagnosis (CAD) system for quantifying and visualizing alveolar bone resorption caused by periodontitis was developed based on three-dimensional (3D) image processing of dental CT images. Methods The proposed system enables visualization and quantification of resorption of alveolar bone surrounding and between the roots of teeth. It has the following functions: (1) vertical measurement of the depth of resorption surrounding the tooth in 3D images, avoiding physical obstruction; (2) quantification of the amount of resorption in the furcation area; and (3) visualization of quantification results by pseudo-color maps, graphs, and motion pictures. The resorption measurement accuracy in the area surrounding teeth was evaluated by comparing with dentist's recognition on five real patient CT images, giving average absolute difference of 0.87 mm. An artificial image with mathematical truth was also used for measurement evaluation. Results The average absolute difference was 0.36 and 0.10 mm for surrounding and furcation areas, respectively. The system provides an intuitive presentation of the measurement results. Conclusion Computer aided diagnosis of 3D dental CT scans is feasible and the technique is a promising new tool for the quantitative evaluation of periodontal bone loss. (orig.)

Nagao, Jiro; Mori, Kensaku; Kitasaka, Takayuki; Suenaga, Yasuhito [Nagoya University, Graduate School of Information Science, Nagoya (Japan); Yamada, Shohzoh; Naitoh, Munetaka [Aichi-Gakuin University, School of Dentistry, Nagoya (Japan)

2007-06-15

19

Effects of smoking on edentulous alveolar ridge mucosa  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction Tobacco use is an important risk factor for advanced histopathological findings on edentulous alveolar ridge mucosa. The aim of this study was to examine the effects of smoking on histopathological findings on edentulous alveolar ridge mucosa. Material and methods The experimental group consisted of 48 patients (29 smokers and 19 nonsmokers). The mean age of smokers was 42.6 and of nonsmokers 48.7 years. The anamnesis included the following data: age, sex, diseases and toxic habits-cigarette smoking. Biopsy samples were taken from the edentulous alveolar ridge mucosa without gross signs of symptoms. Results The mean number of cigarettes smoked per day was 11.5±7. The results of ?² test proved that there were no statistically significant differences (p>0.05) in histopathological findings on the alveolar ridge mucosa. The mean duration of smoking was 12.7± 5 years. Hyperkeratosis was established in 76.92% of smokers who smoked longer than 15 years. The mean-age at which smokers began smoking was 27.3±8 years and there were no statistically significant differences in histopathological findings on the alveolar ridge mucosa correlated with the beginning of smoking. Conclusion On the basis of our research we conclude that smokers who have been smoking for 15 years are at risk for developing histopathological changes of the alveolar ridge mucosa, but there were no statistically significant differences in histopathological findings on the alveolar ridge mucosa correlated with the number of cigarettes per day and the beginning of smoking. .

Markovi? Dubravka; Vu?kovi? Nada; Jefi? Bojana; Strajni? Ljiljana; Mirkovi? Siniša

2005-01-01

20

Orthodontically induced root and alveolar bone resorption: inhibitory effect of systemic doxycycline administration in rats.  

Science.gov (United States)

The aim of the present study was to investigate the effect of systemic administration of low-dose doxycycline (DC) on orthodontic root resorption. The effect on alveolar bone, the cell population involved, and the amount of tooth movement were also evaluated.Fifty-six 40-50-day-old male Wistar rats were used. Six animals served as untreated controls. Six animals were only administered DC for 7 days, by means of a mini-osmotic pump implanted subcutaneously. In 44 animals the maxillary first molar was mesialized by a fixed orthodontic appliance exerting 50 g force upon insertion. In 28 of these animals DC was administered at the time of appliance insertion and throughout the experiment. The animals were sacrificed 7, 10 or 14 days after force application and block sections processed for analysis. An area including the mesial aspect of the distopalatal root and the adjacent inter-radicular alveolar bone was histomorphometrically evaluated. The root resorption area, absolute alveolar bone area, distance between first and second molars, number of odontoclasts, osteoclasts, mononuclear cells on the root, tartrate-resistant acid phosphatase (TRAP)-positive cells on the root, bone, and in the periodontal ligament (PDL) were compared between DC-treated and non-DC-treated animals. The results revealed a significant reduction in root resorption, the number of odontoclasts, osteoclasts, mononuclear cells on the root surface, and TRAP-positive cells on the root and bone for the DC-administered group. The absolute alveolar bone area was greater, whereas the distance between the first and second molars did not differ between groups. In conclusion, systemic administration of low-dose DC in rats may have an inhibitory effect on orthodontically induced resorptive activity. PMID:15947219

Mavragani, Maria; Brudvik, Pongsri; Selvig, Knut Andreas

2005-06-01

 
 
 
 
21

Orthodontically induced root and alveolar bone resorption: inhibitory effect of systemic doxycycline administration in rats.  

UK PubMed Central (United Kingdom)

The aim of the present study was to investigate the effect of systemic administration of low-dose doxycycline (DC) on orthodontic root resorption. The effect on alveolar bone, the cell population involved, and the amount of tooth movement were also evaluated.Fifty-six 40-50-day-old male Wistar rats were used. Six animals served as untreated controls. Six animals were only administered DC for 7 days, by means of a mini-osmotic pump implanted subcutaneously. In 44 animals the maxillary first molar was mesialized by a fixed orthodontic appliance exerting 50 g force upon insertion. In 28 of these animals DC was administered at the time of appliance insertion and throughout the experiment. The animals were sacrificed 7, 10 or 14 days after force application and block sections processed for analysis. An area including the mesial aspect of the distopalatal root and the adjacent inter-radicular alveolar bone was histomorphometrically evaluated. The root resorption area, absolute alveolar bone area, distance between first and second molars, number of odontoclasts, osteoclasts, mononuclear cells on the root, tartrate-resistant acid phosphatase (TRAP)-positive cells on the root, bone, and in the periodontal ligament (PDL) were compared between DC-treated and non-DC-treated animals. The results revealed a significant reduction in root resorption, the number of odontoclasts, osteoclasts, mononuclear cells on the root surface, and TRAP-positive cells on the root and bone for the DC-administered group. The absolute alveolar bone area was greater, whereas the distance between the first and second molars did not differ between groups. In conclusion, systemic administration of low-dose DC in rats may have an inhibitory effect on orthodontically induced resorptive activity.

Mavragani M; Brudvik P; Selvig KA

2005-06-01

22

Alveolar ridge reduction after tooth extraction in adolescents: an animal study.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The mechanism for tooth extraction induced residual alveolar ridge reduction (RRR) during adolescence is poorly understood. This study investigated the alveolar bone morphology, growth, resorption and functional loading at normal and extraction sites using an adolescent pig model. DESIGN: Sixteen 3-month-old pigs were divided into two groups - immediate post-extraction (IE) and 6-week post-extraction (SE). The IE group received an extraction of one deciduous mandibular molar, immediately followed by a final experiment to record masseter muscle EMGs and strains from the buccal surface of the extraction and contralateral non-extraction sites during function (mastication). The SE group was given the same tooth extraction, then kept for 6 weeks before the same final functional recording as the IE group. Both groups also received baseline (pre-extraction) EMGs and fluorescent vital stains 10 and 3 days before the final functional recording. Immediately after the final functional recording, animals were euthanized and alveolar bone specimens from extraction and contralateral non-extraction sites were collected and used to analyse alveolar bone morphology, apposition and resorption based on fluorescent and hematoxylin and eosin stained histological sections. RESULTS: At control sites (IE-extraction, IE-non-extraction and SE-non-extraction), the alveolar ridges grew gingivally and buccally. Bone formation characterized the buccal surface and lingual bundle bone, whereas resorption characterized the lingual surface and buccal bundle bone. The SE-extraction sites showed three major alterations: convergence of the buccal and lingual gingival crests, loss of apposition on the lingual bundle bone, and decelerated growth at the entire buccal surface. These alterations likely resulted from redirected crestal growth as part of the socket healing process, loss of tongue pressure to the lingual side of the teeth which normally provides mechanical stimulation for dental arch expansion, and masticatory underloading during the initial post-extraction period, respectively. CONCLUSIONS: These data indicate that the initial phase of RRR in adolescents is a product of modified growth, not resorption, possibly because of decreased mechanical stimulation at the extraction site.

Sun Z; Herring SW; Tee BC; Gales J

2013-07-01

23

Improving prosthetic prognosis by connective tissue ridge augmentation of alveolar ridge  

Directory of Open Access Journals (Sweden)

Full Text Available The contour of edentulous ridge should be carefully evaluated before a fixed partial denture is undertaken. The ideal ridge height and width allows placement of a natural looking pontic which facilitates maintenance of plaque-free environment. The localized alveolar ridge defect refers to the volumetric deficit of the limited extent of bone and soft tissue within the alveolar process. Such type of ridge defects can be corrected by surgical ridge augmentation that can be accomplished by the addition of either soft or hard tissues. This article describes a procedure of surgical connective tissue augmentation of a localized deficient alveolar ridge in the maxilla, followed by fixed partial denture, enhancing the esthetics, function and health.

Mishra Niraj; Singh Balendra; Rao Jitendra; Rastogi Pavitra

2010-01-01

24

Alveolar ridge preservation using resorbable bioactive ceramic composite: a histological study.  

UK PubMed Central (United Kingdom)

PURPOSE: The purpose of this study was to histologically evaluate newly generated vital bone using porous granules of bioactive and resorbable silica-calcium phosphate nanocomposite (SCPC) in extraction sockets. MATERIAL AND METHODS: Six patients with a non-restorable maxillary central incisor requiring extraction followed by implant placement participated in the study. Extraction sockets were grafted with granules of SCPC. After 6 months, a bone core sample was retrieved from the center of the healed socket for histologic analysis, and dental implants were placed. Alveolar bone width was clinically assessed immediately after tooth extraction and 6 months after bone grafting, at the time of implant placement. Alveolar bone height was radiographically assessed immediately after tooth extraction and 6 months after extraction. RESULTS: Histomorphometric analyses of sockets grafted with SCPC for 6 months revealed 46.8% +/- 14% new vital bone and 2.5% +/- 1.5% graft material remnants. In these sockets, the mean bone height resorption over the 6-month period of healing was 1.6 mm +/- 1.5 mm. The mean bone width resorption of 2 mm +/- 0.7 mm was found at the bone crest. CONCLUSION: The results of this study suggest that SCPC graft material reduces the amount of change in alveolar ridge dimensions after tooth extraction and facilitates the regeneration of new vital bone.

Al-Sabbagh M; Burt J; Barakat A; Kutkut A; El-Ghannam A

2013-07-01

25

A prospective, multicenter study of bovine pericardium membrane with cancellous particulate allograft for localized alveolar ridge augmentation.  

UK PubMed Central (United Kingdom)

Resorption of the alveolar ridge may lead to ridge deformities that make dental implant placement difficult or impossible. Augmentation of the alveolar ridge may restore appropriate ridge form to allow implant placement. Forty-four patients with edentulous spaces completed this multicenter prospective trial to clinically and radiographically evaluate the efficacy of a bovine pericardium membrane and a particulate mineralized cancellous bone allograft in promoting lateral ridge augmentation. Overall, 38 of 44 patients (86.4%) were able to receive dental implants in the appropriate restoratively driven position 6 months after ridge augmentation. The mean gain in clinical ridge width after augmentation was 2.61 mm, while radiographically the mean gain in ridge width was 1.65 mm at a level 3 mm apical to the bony crest and 1.93 mm at a level 6 mm apical to the crest. On average, approximately 50% of the graft material added horizontally during surgery was displaced or resorbed during healing. Histomorphometric evaluation of cores taken from the augmented ridge at 6 months revealed that approximately 58% of the tissue volume was vital bone, with 12% residual allograft particles and 30% nonmineralized tissue.

Sterio TW; Katancik JA; Blanchard SB; Xenoudi P; Mealey BL

2013-07-01

26

Horizontal alveolar ridge distraction in an edentulous patient.  

UK PubMed Central (United Kingdom)

PURPOSE: Full fixed dental rehabilitation, including attachment based over denture (to dental implants) is the optimal solution for edentulous patients, although the insertion of implants will be impossible when the alveolar ridge has been horizontally and severely absorbed. A full arch narrow ("knife-edge") alveolar crest creates a "borderline" condition. Dental implants cannot be inserted into a narrow ridge, which is also at risk of rapid absorption, especially under the pressure of a full denture. Current clinical solutions have been limited. In bone augmentation, the bone absorption rate has been approximately 50%, requiring 6-month therapy prolongation for the grafted bone to consolidate. MATERIALS AND METHODS: We have described an edentulous patient whose "knife-edge" maxillary alveolar crest was widened with crest expanders (horizontal distractors). RESULTS: Only 6 weeks after initiation of the distraction, a wide enough ridge had been created, allowing bilateral insertion of implants, followed by attachment-based full dental rehabilitation. Bone augmentation was avoided, and the implants were placed in the correct lateral position, with sufficient attached gingiva obtained. CONCLUSIONS: Horizontal crest expanding in narrow-alveolar edentulous patients can significantly reduce both morbidity and the therapeutic period and substantially increase the therapeutic success rate, based on both soft tissue and bone distraction. With this technique, our patient was without the denture for only 6 weeks.

Laster Z; Reem Y; Nagler R

2011-02-01

27

A radiographic study on the prevalence of knife-edge residual alveolar ridge at proposed dental implant sites  

International Nuclear Information System (INIS)

Dental implants are widely used in restoration of completely or partially edentulous dental arches. Before placement of endosseous implants in the jaws, both the quantity and quality of the residual ridge must be assessed radiographically. Remodeling activity after tooth extraction is localized primarily at the crestal area of the residual ridges, resulting in reduction of the height of bone and creation of various three-dimensional shapes of the residual ridges. When bone resorption at the lingual and buccal aspects is greater than that at the crestal area, a knife-edge type of residual ridge develops. The aim of this study was to evaluate the prevalence of the knife-edge morphology of the residual alveolar bone at proposed implant sites in partially or completely edentulous patients. Computed tomography (CT) cross-sectional images of the upper and lower jaws were assessed at the proposed sites before implant placement. Images of 258 proposed implant sites belonging to 30 patients were assessed radiographically. In 120 proposed implant sites out of 258 (46.5%), the residual alveolar ridge had a knife-edge configuration, the majority belonging to completely edentulous patients who lost their teeth more than ten years previously. High prevalence of knife-edge ridge was found, therefore, replacement of missing teeth by immediate implant is recommended to prevent atrophy or knife-edge morphology of the residual ridge. (author)

2009-01-01

28

Determinants of alveolar ridge preservation differ by anatomic location.  

UK PubMed Central (United Kingdom)

AIM: To investigate and compare outcomes following alveolar ridge preservation (ARP) in posterior maxilla and mandible. METHODS: Twenty-four patients (54 ± 3 years) with single posterior tooth extraction were included. ARP was performed with freeze-dried bone allograft and collagen membrane. Clinical parameters were recorded at extraction and re-entry. Harvested bone cores were analysed by microcomputed tomography (micro-CT), histomorphometry and immunohistochemistry. RESULTS: In both jaws, ARP prevented ridge height loss, but ridge width was significantly reduced by approximately 2.5 mm. Healing time, initial clinical attachment loss and amount of keratinized tissue at extraction site were identified as determinants of ridge height outcome. Buccal plate thickness and tooth root length were identified as determinants of ridge width outcome. In addition, initial ridge width was positively correlated with ridge width loss. Micro-CT revealed greater mineralization per unit volume in new bone compared with existing bone in mandible (p < 0.001). Distributions of residual graft, new cellular bone and immature tissue were similar in both jaws. CONCLUSION: Within the limitations of this study, the results indicate that in different anatomic locations different factors may determine ARP outcomes. Further studies are needed to better understand determinants of ARP outcomes.

Leblebicioglu B; Salas M; Ort Y; Johnson A; Yildiz VO; Kim DG; Agarwal S; Tatakis DN

2013-04-01

29

Pyogenic granuloma of unusual size with alveolar resorption in a 75-year-old patient.  

UK PubMed Central (United Kingdom)

Pyogenic granuloma is an overzealously proliferative non-neoplastic lesion of connective tissue origin, found commonly in oral cavity and is secondary to chronic low grade local irritation, poor oral hygiene, and hormonal disturbances. The term is misnomer because a lesion is unrelated to infection. It is characterized by excessive and exuberant tissue repair response with varied inflammatory component. Since it is a benign lesion, choice of treatment is surgical excision with removal of underlying cause if any. This article aims at presenting a case of pyogenic granuloma in an extremely old patient which is unusual as it attained a very large size and also has caused mild resorption of underlying alveolar bone of mandible.

Shaikh S; Singh G; Singh A; Gaur A

2012-01-01

30

Alveolar ridge augmentation using chin bone graft, bovine bone mineral, and titanium mesh: Clinical, histological, and histomorphomtric study.  

UK PubMed Central (United Kingdom)

BACKGROUND: Resorption of the alveolar ridge often leaves insufficient bone volume. Very few studies have investigated the quantity and quality of bone formation in humans, following alveolar ridge augmentation, using autogenous bone and bovine bone mineral (BBM) under titanium mesh. MATERIALS AND METHODS: Sixteen alveolar bone defects divided into two groups; control group with symphyseal autogenous bone covered by titanium mesh; and test group with symphyseal autogenous bone mixed with BBM in 1: 1 ratio and covered by titanium mesh. The outcomes were evaluated clinically, histologically, and histomorphometrically. RESULTS: Clinical measurements showed that the horizontal bone gain was 3.44±0.54 mm and 2.88±0.57 mm, on average, for control group and test group, respectively. While graft absorption was 2.66±0.98 mm (43.62%) and 1.67±1.00 mm (36.65%), on average, for control group and test group, respectively. In the test group, BBM particles were still recognizable, on histologic analysis. They were surrounded completely or partly by newly formed bone. Clear signs of resorption of the BBM were found, with osteoclast cell noticed in the area. Histomorphometrically, the newly formed bone was 78.40%±13.97% and 65.58%±6.59%, whereas connective tissue constituted 21.60%±13.97% and 23.87%±4.79% for control group and test group, respectively. The remaining BBM particles occupied 10.55%±1.80%. All differences between the control and test groups were not significant (P>.05). CONCLUSION: This investigation suggests that horizonal ridge augmentation with titanium mesh and autogenous bone alone or mixed with BBM are predictable and ridges were augmented even if mesh exposure occurs.

Khamees J; Darwiche MA; Kochaji N

2012-04-01

31

Systemic Osteoporosis and Reduction of the Edentulous Alveolar Ridge  

Directory of Open Access Journals (Sweden)

Full Text Available Systemic osteoporosis can damage skeletal bones to different degrees or remain persistent in intensity. The aim of this study was to determine the intensity and correlation of the osteoporotic changes in the bone density of the skeleton and body mass index (BMI) with a reduction in edentulous mandibles. Material and Methods: In this study, 89 edentulous patients with decreased bone density comprised the experimental group, and 43 edentulous patients with normal bone densities formed the control. The age of the patients ranged between 53 and 73 years. Radiographs of the hands and panoramic radiographs were done for all the patients. The values of BMI, metacarpal index , density of lumbar spine (L2-L4), in the phalanx and segments of the mandibles as well as the heights of the edentulous alveolar ridges were measured, assessed and calculated.Results: The lowest value of the total skeletal density was established in the osteoporotic patients on the basis of the average T-score of -2.5 in men, and - 2.6 in women. Minimum values of the heights of the edentulous ridges (right/left, in mm) were measured in both osteoporotic female (21.84/22.39) and male (24.90/24.96) patients. By comparison of the densities of the metacarpal bones, proximal phalanx, segments of the edentulous mandibles and based on the numerical values of the heights of the edentulous ridges, ?²=3.81 was found in men and ?²=4.03 was found in women with normal bone densities; ?²=5.92 was found in men and ?²=6.25 was found in women with osteopenia; ?²=2.63 was found in men and ?²=3.85 was found in women with osteoporosis, on the P level of probability of 0.05. Conclusion: Systemic osteoporosis causes a decrease of the jawbone density and induces residual edentulous alveolar ridge reduction.

Sr?an D. Pošti?; Nada Vujasinovi?-Stupar; Zoran Rako?evi?

2013-01-01

32

Aumento del reborde alveolar residual mediante técnica de rollo/ Increase of residual alveolar ridge using roll technique  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish La pérdida dentaria, asociada a factores sistémicos, patológicos y traumáticos, promueve el proceso de reabsorción ósea de los rebordes residuales y genera problemas funcionales, como la falta de estabilidad y retención de las prótesis dentarias removibles, y disturbios estéticos y psicológicos. Estos defectos varían en dependencia de la cantidad de pérdida ósea y de tejidos blandos que hayan alcanzado. En la actualidad son descritas diversas técnicas que pe (more) rmiten corregir estos defectos. Una de ellas es la técnica del rollo, la cual demuestra muy buenos resultados al aumentar el tamaño del reborde alveolar y disminuir los defectos estéticos que causa sobre todo en el sector anterior. El objetivo del presente artículo es describir el caso clínico de un paciente con pérdida ósea en el sector anterior, tipo III según Seibert, rehabilitado con prótesis parcial fija y sometido a un procedimiento quirúrgico con la técnica del rollo. Se alcanzaron los objetivos planteados y proporciona una mejoría estética así como una mejora en su calidad de vida. Se demostró que con esta técnica se obtienen resultados predecibles que devuelven la estética en zonas de alta exigencia por parte de los pacientes. Abstract in english Tooth loss associated with systemic factors, pathological and traumatic conditions, promotes the bone resorption of residual ridges, this, creates functional problems such as lack of stability and retention of removable dentures as well as aesthetic and psychological disturbances. These defects vary depending on the amount of bone loss and soft tissue they reach. At present there are described various techniques that can correct these defects. One of these is the roll tec (more) hnique which shows very good results by increasing the size of the alveolar ridge and decrease aesthetic defects in the anterior area of the maxilla. The aim of this article is to describe a case of a patient with Seibert bone loss type III, rehabilitated with fixed partial denture after undergoing a surgical procedure with the roll technique achieving the stated objectives and providing aesthetic improvement to the patient and an improvement in their quality of life. It is shown that the technique can be achieved with predictable results that return aesthetics in areas of high demand from patients.

Simancas Pallares, Miguel Ángel; Herrera Herrera, Alejandra del Carmen; Arévalo Tovar, Luisa Leonor; Díaz Caballero, Antonio José; González Martínez, Farith Damián

2011-03-01

33

Distracción osteogénica del reborde alveolar: revisión de la literatura/ Distraction osteogenesis of the alveolar ridge: a review of the literature  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Uno de los principales problemas para la colocación de implantes dentales es la presencia de hueso insuficiente que impide que sean de una longitud y/o de un diámetro adecuados. Dentro de los métodos que se usan para el aumento del reborde alveolar se incluye tan solo desde hace una década la aplicación de los principios de distracción osteogénica (DO). Esta técnica se basa en la separación gradual de dos fragmentos de hueso perfectamente vascularizados, entre lo (more) s que se forma un callo de distracción que progresivamente se transforma en hueso maduro. Un científico clave en el desarrollo de esta técnica fue el traumatólogo ruso Ilizarov. Esta revisión bibliográfica evalúa la metodología, el funcionamiento y las posibles aplicaciones de DO en el tratamiento de los defectos del reborde alveolar. Por sus cualidades demostradas, la DO podría sustituir el uso de injertos y regeneración ósea guiada para favorecer las relaciones esqueléticas de los rebordes alveolares. Abstract in english One of the principal problems in dental implantation is the lack of sufficient bone height or width. In the case of the alveolar ridge, a very effective technique for resolving this problem is distraction osteogenesis, introduced in this context about a decade ago. This technique is based on the gradual separation of a mobile but fully vascularized bone segment from the basal bone, leading to the formation of an intervening soft callus which gradually transforms to mature (more) bone. A key researcher in the development of this technique was the Russian traumatologist Ilizarov. The present article reviews alveolar ridge distraction procedures and their clinical application. Alveolar ridge distraction may often be preferable to bone grafting or guided bone regeneration for increasing ridge height and width prior to implantation.

Saulacic, Nikola; Gándara Vila, Pilar; Somoza Martín, Manuel; García García, Abel

2004-10-01

34

Combined orthodontic temporary anchorage devices and surgical management of the alveolar ridge augmentation using distraction osteogenesis.  

UK PubMed Central (United Kingdom)

PURPOSE: Distraction osteogenesis is used to increase the vertical and transverse bone volume of the alveolar ridge and requires 3-dimensional vector controls. Temporary anchorage devices (TADs) may be inserted into the transported segment, enabling distraction vector control by exerting orthodontic force. The authors' aim was to describe a combined orthodontic surgical technique involving vertical alveolar distraction using TADs. MATERIALS AND METHODS: Four patients who presented with extensive anterior alveolar ridge bone loss combined with the incisors and canines underwent treatment according to a combined surgical orthodontic protocol, including presurgical orthodontic preparation and a preimplantation surgical augmentation stage involving vertical distractor insertion. During the active vertical alveolar distraction process, 3 TADs were inserted. Intraoral orthodontic elastics were attached to the main orthodontic archwire exerting multidirectional forces to control the vertical distraction vector. After 4 to 5 months of vector controlling and active bone molding, the TADs were removed. RESULTS: Anterior alveolar ridge augmentation using distraction osteogenesis was achieved. The application of TADs for better anterior segment curvature enabled dental implant insertion, ideal positioning, and restoration. CONCLUSIONS: A combined surgical orthodontic management protocol involving vertical alveolar distraction osteogenesis for augmentation purposes using TADs enables improved alveolar ridge volume and architecture for the preimplantation stage.

Aizenbud D; Hazan-Molina H; Cohen M; Rachmiel A

2012-08-01

35

Alveolar Ridge and Maxillary Sinus Augmentation Using rhBMP-2: A Systematic Review.  

UK PubMed Central (United Kingdom)

PURPOSE: The aim of this systematic review was to evaluate clinical and safety data for recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier when used for alveolar ridge/maxillary sinus augmentation in humans. MATERIALS AND METHODS: Clinical studies/case series published 1980 through June 2012 using rhBMP-2/ACS were searched. Studies meeting the following criteria were considered eligible for inclusion: >10 subjects at baseline and maxillary sinus or alveolar ridge augmentation not concomitant with implant placement. RESULTS: Seven of 69 publications were eligible for review. rhBMP-2/ACS yielded clinically meaningful bone formation for maxillary sinus augmentation that would allow placement of regular dental implants without consistent differences between rhBMP-2 concentrations. Nevertheless, the statistical analysis showed that sinus augmentation following autogenous bone graft was significantly greater (mean bone height: 1.6?mm, 95% CI: 0.5-2.7?mm) than for rhBMP-2/ACS (rhBMP-2 at 1.5?mg/mL). In extraction sockets, rhBMP-2/ACS maintained alveolar ridge height while enhancing alveolar ridge width. Safety reports did not represent concerns for the proposed indications. CONCLUSIONS: rhBMP-2/ACS appears a promising alternative to autogenous bone grafts for alveolar ridge/maxillary sinus augmentation; dose and carrier optimization may expand its efficacy, use, and clinical application.

de Freitas RM; Spin-Neto R; Junior EM; Pereira LA; Wikesjö UM; Susin C

2013-09-01

36

The effect of frequent removable partial denture wearing on alveolar bone resorption.  

UK PubMed Central (United Kingdom)

Aim To determine the influence of frequent removable partial denture (RPD) wearing on the alveolar bone density changes around the abutment teeth. Methods Fifty examinees of both genders, wearing partial dentures, were included in the study. Thirty one of the examinees (62%) were wearing the dentures 24 hours a day, while nineteen (34%) of them were wearing them only during the day. The changes in the bone density around the abutment teeth were determined by the intraoral microdensitometry method. Standard retroalveolar radiographs were performed twice. The first one before the removable partial denture delivery and the second one after a period of three-month denture wearing. A copper step wedge consisting of five steps (0.1-0.5 mm) was attached to the radiograph in order to calibrate it. Seven points, regions of interest (ROI) close to the root of the abutment tooth, all ten pixels in size, were selected on each radiograph. Grey areas in the regions of interest were measured and converted into the copper step wedge thickness equivalents in order to estimate the change in the alveolar bone density and measure the difference in alveolar bone density between two radiographs. Results The results indicated that there is not any statistically relevant change (t-value less than 2,011; t(49,0.05) / F less than 4,0426; F0.05(1,48)) in the alveolar bone density depending on the frequency of removable partial denture wearing. Conclusion The frequency of removable partial denture wearing does not cause any changes in the alveolar bone density around the abutment teeth in the period of three-month denture wearing. Key words: alveolar bone, removable denture, radiography.

Kova?evi? Pavi?i? D; Lajnert V; Simoni? Kocijan S; Uha? I; Glavi?i? S; Kova? Z

2013-08-01

37

Localized lateral alveolar ridge augmentation with block bone grafts: simultaneous versus delayed implant placement: a clinical and radiographic retrospective study.  

UK PubMed Central (United Kingdom)

PURPOSE: To retrospectively evaluate the 1-year outcome of implant therapy involving localized lateral alveolar ridge augmentation with block bone grafts, and to compare outcomes of implants inserted simultaneously with grafting or after a healing period. MATERIALS AND METHODS: Consecutively treated patients undergoing alveolar ridge augmentation with autogenous intraoral block grafts before or simultaneous with implant placement between 2005 and 2010 in the Oral Surgery Unit of the University of Valencia were included. The selection of procedure (simultaneous vs delayed implant placement, donor site) was based upon the criterion of the surgeon and thorough evaluation of each patient. All grafts were obtained with piezosurgery. Complications related to augmentation, implant survival, implant success, and peri-implant marginal bone loss were assessed. RESULTS: Forty-two patients were included; 45 sites were augmented and 71 implants were inserted (33 delayed and 38 simultaneously). Complications (temporary paresthesia, wound dehiscence with bone graft exposure, and exposure of osteosynthesis screw) occurred after bone harvesting in nine patients; four were in the simultaneous group and five were in the delayed group. Six grafts were not successful; four were lost and two provided insufficient bone (after resorption) for ideal implant placement. The implant survival rate was 98.5% (100% for simultaneous and 96.9% for delayed implants) and the implant success rate was 92.9% (89.5% for simultaneous and 96.9% for delayed implants). Average marginal bone loss 1 year after loading was significantly higher for simultaneously placed implants (0.69 ± 0.67 mm) than for delayed implants (0.20 ± 0.50 mm). CONCLUSIONS: In lateral bone atrophy, block bone grafts provided sufficient bone for implant therapy, with few complications. Both simultaneous and delayed implant placement yielded high implant survival and success rates. Average marginal bone loss was significantly higher around simultaneously inserted implants.

Peñarrocha-Diago M; Aloy-Prósper A; Peñarrocha-Oltra D; Guirado JL; Peñarrocha-Diago M

2013-05-01

38

Alveolar Ridge and Maxillary Sinus Augmentation Using rhBMP-2 : A Systematic Review  

DEFF Research Database (Denmark)

The aim of this systematic review was to evaluate clinical and safety data for recombinant human bone morphogenetic protein-2 (rhBMP-2) in an absorbable collagen sponge (ACS) carrier when used for alveolar ridge/maxillary sinus augmentation in humans.

de Freitas, Rubens Moreno; Spin-Neto, Rubens

2013-01-01

39

3D vector control during alveolar ridge augmentation using distraction osteogenesis and temporary anchorage devices: a new technique.  

UK PubMed Central (United Kingdom)

This report describes a combined orthodontic surgical technique involving vertical alveolar distraction using temporary anchorage devices (TADs) in cases of massive alveolar ridge bone and teeth loss. A combined surgical orthodontic protocol included presurgical orthodontic preparation and a preimplantation surgical augmentation stage for insertion of a vertical distractor. During the active vertical alveolar distraction process TADs were inserted. Intraoral orthodontic elastics were attached to the main orthodontic archwire exerting multidirectional forces to control the vertical distraction vector. After 3 months of vector controlling and active bone moulding, the TADs were removed. Anterior alveolar ridge augmentation using distraction osteogenesis was achieved. The application of TADs for better anterior segment curvature enabled dental implant insertion, better positioning and restoration. A combined surgical orthodontic management protocol involving vertical alveolar distraction osteogenesis for augmentation purposes is an efficient treatment method to improve alveolar ridge volume for the preimplantation stage.

Aizenbud D; Hazan-Molina H; Cohen M; Rachmiel A

2012-02-01

40

Dimensional alterations of extraction sites after different alveolar ridge preservation techniques - a volumetric study.  

UK PubMed Central (United Kingdom)

OBJECTIVES: The aim of this randomized controlled clinical study was to assess soft tissue contour changes after different alveolar ridge preservation procedures. MATERIAL AND METHODS: Following tooth extraction, 30 patients were randomly assigned to the following treatments (Tx) - Tx 1: xenogenic bone substitute (pre-hydrated collagenated cortico-cancellous porcine bone) and free gingival graft; Tx 2: free gingival graft alone; Tx 3: xenogenic bone substitute; Tx 4: no further treatment (control). Impressions were obtained before tooth extraction (baseline) and 4 months after surgery. Cast models were optically scanned, digitally superimposed and horizontal measurements of the contour alterations between time points were performed using digital imaging analysis. RESULTS: All groups displayed contour shrinkage at the buccal aspect ranging from a mean horizontal reduction of -0.8 ± 0.5 mm (Tx 1) to -2.3 ± 1.1 mm (control). Statistically significant differences were found between Tx 1 and Tx 4 as well as Tx 2 and Tx 4. A significant positive influence of the free gingival graft on the maintenance of the ridge width was recorded (p < 0.001). CONCLUSION: In this study, alveolar ridge preservation techniques were not able to entirely compensate for alveolar ridge reduction. Covering the orifice of the extraction socket with a free gingival tissue graft seems to have the potential to limit but not avoid the post-operative external contour shrinkage based on optical scans.

Thalmair T; Fickl S; Schneider D; Hinze M; Wachtel H

2013-07-01

 
 
 
 
41

[Clinical application of alveolar ridge augment of posterior mandible using modified sandwich technique with immediate implantations].  

UK PubMed Central (United Kingdom)

PURPOSE: To evaluate the clinical values of alveolar ridge augment of atrophic posterior mandible using modified sandwich technique with immediate implantations, METHODS: Three patients with atrophic posterior mandible were enrolled in this study. A sandwich osteotomy was performed using a piezosurgery device, and 2 submerged implants were placed in approximal locations simultaneously to support and stabilize the osteotomy segments. Some xenografts were inserted into sandwich region and a GBR membrane was applied during operations. After 6 months, definitive prostheses were completed. RESULTS: No dehiscence of the mucosa was observed in all patients. 2 patients' swelling gradually disappeared after a therapy with antibiotics and dexamethasone for 3 days. Six months later, newly formed bones were observed near the osteotomized segments, and peri-implant area showed osseointegration. The mean height of augmentation was about 5mm. CONCLUSION: Augmentation of alveolar ridge with immediate implantations using modified sandwich technique is applicable.

Guo ZZ; Zhang H; Zhou TT; Yang X; Liu X; Wu JB

2013-04-01

42

[A newborn with a tumour on the tongue and alveolar ridge].  

Science.gov (United States)

In a newborn boy, a tumour was seen on the tongue and mandibula. A diagnosis of congenital epulis was made. This usually pedunculated tumour is present at birth and located on the maxillary or mandibular alveolar ridge (more commonly on the maxilla), but rarely on the tongue. It varies greatly in size from just a few millimetres in diameter to several centimetres. Treatment is only necessary when feeding problems occur. PMID:23369813

Boukes, Froukje S; Ramdat Misier, Dinesh R; Lopuhaä, Christa E

2013-01-01

43

Lost salt technique for severely resorbed alveolar ridges: An innovative approach.  

UK PubMed Central (United Kingdom)

The success of a complete denture relies on the principles of retention, stability and support. The prosthodontist skill lies in applying these principles efficiently in critical situations. Severely resorbed maxillary edentulous ridges that are narrow and constricted with increased inter ridge space provide decreased support, retention and stability. The consequent weight of the processed denture only compromises them further. This article describes a case report of an edentulous patient with resorbed ridges where a simplified technique of fabricating a hollow maxillary complete denture using lost salt technique was used for preservation of denture bearing areas. The hollowing of the denture reduces the weight of the denture, thereby enhancing stability and retention, reducing the further resorption of the jaws.

Aggarwal H; Jurel SK; Singh RD; Chand P; Kumar P

2012-07-01

44

Lost salt technique for severely resorbed alveolar ridges: An innovative approach.  

Science.gov (United States)

The success of a complete denture relies on the principles of retention, stability and support. The prosthodontist skill lies in applying these principles efficiently in critical situations. Severely resorbed maxillary edentulous ridges that are narrow and constricted with increased inter ridge space provide decreased support, retention and stability. The consequent weight of the processed denture only compromises them further. This article describes a case report of an edentulous patient with resorbed ridges where a simplified technique of fabricating a hollow maxillary complete denture using lost salt technique was used for preservation of denture bearing areas. The hollowing of the denture reduces the weight of the denture, thereby enhancing stability and retention, reducing the further resorption of the jaws. PMID:23293499

Aggarwal, Himanshi; Jurel, Sunit K; Singh, Raghuwar D; Chand, Pooran; Kumar, Pradeep

2012-07-01

45

Alveolar ridge width and height changes after orthodontic space opening in patients congenitally missing maxillary lateral incisors.  

UK PubMed Central (United Kingdom)

The purpose of this study was to evaluate the dimensional changes of the alveolar ridge in patients with congenitally missing maxillary lateral incisors. The width and height of the alveolar ridge were compared before and after opening space for an endosseous dental implant between the central incisor and canine. Pre- and post-treatment dental stone models of 31 patients (8 males, 23 females; mean age 15.1 ± 7.9 years pre-treatment, 17.6 ± 8 years post-treatment) with unilaterally or bilaterally, congenitally missing maxillary lateral incisors were used in this study. Pre- and post-treatment measurements included: the space between the maxillary central incisor and canine, the depth of the labial concavity, and the width and height of the lateral incisor alveolar ridge. Two different techniques were used to measure the ridge width. Student's paired samples t-test was used to test for significance. The alveolar ridge underwent statistically significant width loss (Method 1: 4-8 per cent, Method 2: 13-15 per cent) during the course of orthodontic treatment. A 6-12 per cent loss in ridge height was also noted. The depth of the labial concavity between the maxillary central incisor and canine nearly doubled. There was a significant decrease in the width and height of the alveolar ridge in patients congenitally missing a maxillary lateral incisor who received orthodontic treatment to create space for an endosseous dental implant.

Uribe F; Chau V; Padala S; Neace WP; Cutrera A; Nanda R

2013-02-01

46

Distracción osteogénica alveolar: una alternativa en la reconstrucción de rebordes alveolares atróficos: Descripción de 10 casos Alveolar distraction osteogenesis: an alternative in the reconstruction of atrophic alveolar ridges: Report of 10 cases  

Directory of Open Access Journals (Sweden)

Full Text Available La distracción osteogénica alveolar (DOA) es un método alternativo para la reconstrucción de rebordes alveolares atróficos que ofrece un resultado previsible y que disminuye los tiempo de espera entre la reconstrucción del reborde alveolar atrófico y la colocación de los implantes óseo-integrados, en comparación con los métodos tradicionalmente utilizados. Fueron atendidos 10 pacientes que presentaban deficiencia de reborde alveolar mandibular y/o maxilar por medio de distracción osteogénica, utilizando un dispositivo yuxtaoseo (Conexión Implant System® - SP-Brasil). Todos los pacientes fueron atendidos de forma ambulatoria, bajo anestesia local y sedación conciente, comenzando la activación del dispositivo a los 7 días posteriores a la instalación, con un patrón de activación de 1 mm diarios hasta alcanzar la altura ósea deseada. Posteriormente se aguardaron 10 semanas como parte del periodo de consolidación ósea y se realizo la colocación de los implantes oseointegrados y local y el retiro del dispositivo de distracción, pudiéndose comprobar clínica y radiográficamente la ganancia de la altura y volumen óseo necesario para la rehabilitación por medio de implantes.The alveolar distraction osteogenesis is an alternative method for the reconstruction of atrophic alveolar ridges with success, that decrease the time of wait between the reconstruction of the alveolar ridge and the placement of the osseointegrated implants in comparison with the traditionally used methods. 10 patients that presented deficiency of the alveolar ridge in the maxilla and/or mandible were assisted by means of distraction osteogenesis, using a juxtaosseous device (Conexion Implant System® - SP-Brazil). All the patients were assisted of form ambulatory, under local anesthesia and conscientious sedation, beginning the activation from the device 7 days later to the installation, with a pattern of activation 1 mm diary until reaching the wanted bony height. Later on 10 weeks like part of the period of bony consolidation were awaited and one carries out the placement of the osseointegraded implants and the retirement of the distraction device, being able to check clinic and radiographic the gain of the height and necessary bony volume for the rehabilitation by means of implants.

P.E. Maurette O’Brien; M.E. Allais de Maurette; R. Mazzonetto

2004-01-01

47

Distracción osteogénica alveolar: una alternativa en la reconstrucción de rebordes alveolares atróficos: Descripción de 10 casos/ Alveolar distraction osteogenesis: an alternative in the reconstruction of atrophic alveolar ridges: Report of 10 cases  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish La distracción osteogénica alveolar (DOA) es un método alternativo para la reconstrucción de rebordes alveolares atróficos que ofrece un resultado previsible y que disminuye los tiempo de espera entre la reconstrucción del reborde alveolar atrófico y la colocación de los implantes óseo-integrados, en comparación con los métodos tradicionalmente utilizados. Fueron atendidos 10 pacientes que presentaban deficiencia de reborde alveolar mandibular y/o maxilar por m (more) edio de distracción osteogénica, utilizando un dispositivo yuxtaoseo (Conexión Implant System® - SP-Brasil). Todos los pacientes fueron atendidos de forma ambulatoria, bajo anestesia local y sedación conciente, comenzando la activación del dispositivo a los 7 días posteriores a la instalación, con un patrón de activación de 1 mm diarios hasta alcanzar la altura ósea deseada. Posteriormente se aguardaron 10 semanas como parte del periodo de consolidación ósea y se realizo la colocación de los implantes oseointegrados y local y el retiro del dispositivo de distracción, pudiéndose comprobar clínica y radiográficamente la ganancia de la altura y volumen óseo necesario para la rehabilitación por medio de implantes. Abstract in english The alveolar distraction osteogenesis is an alternative method for the reconstruction of atrophic alveolar ridges with success, that decrease the time of wait between the reconstruction of the alveolar ridge and the placement of the osseointegrated implants in comparison with the traditionally used methods. 10 patients that presented deficiency of the alveolar ridge in the maxilla and/or mandible were assisted by means of distraction osteogenesis, using a juxtaosseous dev (more) ice (Conexion Implant System® - SP-Brazil). All the patients were assisted of form ambulatory, under local anesthesia and conscientious sedation, beginning the activation from the device 7 days later to the installation, with a pattern of activation 1 mm diary until reaching the wanted bony height. Later on 10 weeks like part of the period of bony consolidation were awaited and one carries out the placement of the osseointegraded implants and the retirement of the distraction device, being able to check clinic and radiographic the gain of the height and necessary bony volume for the rehabilitation by means of implants.

Maurette O?Brien, P.E.; Allais de Maurette, M.E.; Mazzonetto, R.

2004-02-01

48

[Use of a fibula bone span in alveolar ridge augmentation. Outcome after 2 years  

UK PubMed Central (United Kingdom)

A preliminary report presenting the results of fibular strut grafting in the severely resorbed mandibular and maxillary region is presented. Thirteen patients were treated due to severe resorption of alveolar and basilar bone of 49 segments of the mandible and the maxilla. Two patients additionally had pathological fractures of the mandible. In 10 cases the strut graft was harvested by means of a new minimally invasive technique. After modelling the fibular bone it was fixed to the recipient site by miniscrews or implants. After a mean follow-up period of 20 months (max. 31, min. 11 months) a retrospective analysis of clinical and radiological findings was carried out. It showed that a mean augmentation of 16 mm was achieved. Compared to other studies the fibular strut graft was resorbed less, and due to the primary stability it could be used for the treatment of fractures of the mandible. No more than natural resorption was observed when the patients received their prostheses fixed to dental implants.

Bschorer R; Schmelzle R

1997-09-01

49

Titanium implant insertion into dog alveolar ridges augmented by allogenic material  

DEFF Research Database (Denmark)

The purpose of this investigation was to evaluate whether titanium endosseous implants would osseointegrate in dog alveolar ridges augmented by allogenic material. In 8 dogs en bloc resection, including 2 pre-molars, was performed bilaterally in the maxilla and the mandible. After a healing period of 6 weeks allogenic, demineralized and lyophilized dentin or bone was implanted subperiosteally. Titanium implants were installed 5.5 months later in some of the regions. Light and fluorescence microscopic evaluation revealed fibrous encapsulation of the implanted allogenic material, no osteoinduction and only minimal osteoconduction, few multinuclear giant cells and a sparse inflammatory reaction. The titanium implants healed mainly by fibrous encapsulation.

Pinholt, E M; Haanaes, H R

1994-01-01

50

Chemical, physical, and histologic studies on four commercial apatites used for alveolar ridge augmentation  

DEFF Research Database (Denmark)

The purpose of this study was to evaluate four commercial apatite products. Subperiosteal alveolar ridge augmentation was performed on the maxilla of rats by implantation of granules of two dense products and of two porous products, and the tissue response was compared with the material characteristics obtained by chemical analysis and infrared spectrometry. None of the apatites caused osteoinduction or osteoconduction; fibrous encapsulation with multinuclear giant cells was observed around all four types. One of the apatites was fluorapatite and not hydroxylapatite, as claimed by the manufacturer. The tissue response to this implant material was dominated by multinuclear giant cells.

Pinholt, E M; Ruyter, I E

1992-01-01

51

Alveolar ridge reconstruction with titanium mesh and autogenous particulate bone graft: computed tomography-based evaluations of augmented bone quality and quantity.  

UK PubMed Central (United Kingdom)

PURPOSE: The purpose of this study was to evaluate the quality and quantity of augmented bone following alveolar ridge reconstruction with titanium mesh and autogenous particulate bone graft for implant placement in terms of the preoperative bone defect. MATERIALS AND METHODS: Forty-one patients (50 sites) rehabilitated between September 2000 and May 2009 with autogenous particulate intraoral bone or iliac cancellous bone marrow grafts and micro-titanium meshes were enrolled. We classified the bone defects by means of shape as complex horizontal-vertical (HV), horizontal (H), and socket (S) types, and the augmented bone was evaluated based on preoperative computed tomographic data. The postsurgical complications were assessed during the healing period and after implant superstructure placement. RESULTS: The bone defects were successfully augmented using the titanium mesh technique. The HV-type defect was the most difficult to augment (mean horizontal gain, 3.7 ± 2.0 [SD] mm; mean vertical gain, 5.4 ± 3.4 [SD] mm). The mean horizontal gain with the H-type defect was 3.9 ± 1.9 mm. The S-type defect achieved the most efficient bone augmentation (mean horizontal gain, 5.7 ± 1.4 [SD] mm; mean vertical gain, 12.4 ± 3.1 [SD] mm). The major postsurgical complications were mesh exposure, infection, total or partial bone resorption, and temporary neurological disturbances. Implant failure was observed in one case. The HV-type defect showed significantly higher bone resorption (p < .05) than the other defect types. CONCLUSIONS: Autogenous bone grafting with titanium mesh allows adequate vertical and horizontal alveolar bone reconstruction both quantitatively and qualitatively for implant placement. However, the clinical outcome of augmentation depends on the type of preoperative bone defect.

Miyamoto I; Funaki K; Yamauchi K; Kodama T; Takahashi T

2012-04-01

52

The effect of therapeutic radiation on canine alveolar ridges augmented with hydroxylapatite  

DEFF Research Database (Denmark)

The purpose of this investigation was to evaluate the effect of radiation on hydroxylapatite (HA) implanted subperiosteally for alveolar ridge augmentation in dogs. All bicuspids and molars were extracted from 16 dogs. After 6 weeks, nonporous HA granules were implanted subperiosteally on the alveolar ridge. Following 4 months of healing, 12 dogs (experimental group) underwent therapeutic radiation therapy (Co60, 4,000 rad [40 Gy]) to the head and neck region. Four dogs were not irradiated and served as controls. Four animals (three experimental and one control) were killed at 5,6,7, and 8 months after HA augmentation. Light microscopic evaluation showed that approximately 25% of HA granules were encased by bone while the others were surrounded by fibrous connective tissue. Dissolution of the HA was observed. Microparticles of HA were phagocytized as part of a granulomatous inflammatory reaction. This reaction decreased significantly as time elapsed after implantation. Osteoclastic activity was seen at the junction of HA and periosteum and as part of bone remodeling. Dissolution of the HA granules and the granulomatous inflammatory reaction were not significantly increased by therapeutic radiation. The radiation did not cause development of dehiscence or osteonecrosis.

Pinholt, E M; Kwon, P H

1992-01-01

53

An indirect approach for closing the space between a pontic and the alveolar ridge on an existing prosthesis.  

UK PubMed Central (United Kingdom)

This article describes an alternative method for closing the area between a pontic and the alveolar ridge. An existing restoration could be maintained by resin-bonding an onlay to the intaglio surface of the pontic. This method could be utilized for other cases when it is not feasible to remove an existing fixed dental prosthesis.

Danko E; Roe J

2013-07-01

54

Collagen/hydroxylapatite implant for augmenting deficient alveolar ridges: twelve-month clinical data.  

UK PubMed Central (United Kingdom)

In a multicenter study, 77 edentulous patients had mandibular augmentation with implants of purified fibrillar collagen combined with dense hydroxylapatite (Alveoform Biograft); 22 of these patients also had maxillary augmentation. Most patients had Class III or IV mandibular atrophy, and had outpatient surgery with the subperiosteal tunneling technique. Temporary splints were worn for 24 hours post-surgery. Mean ridge height was 15.3 mm before surgery and 19.5 mm after 12 months, an augmentation of 4.2 mm. Predictable compaction occurred largely in the first few months after denture loading. Most patients, surgeons, and prosthodontists assessed the results of the procedure as good to excellent at 1 year following implantation. Adverse experiences, largely dehiscence and paresthesia, tended to resolve over time. Sera from ten patients demonstrated antibodies to bovine collagen that were not clinically significant. Alveolar augmentation with collagen/hydroxylapatite achieved clinically significant results that compared favorably with those achieved with other types of ceramic implants.

Mehlisch DR; Taylor TD; Leibold DG; Hiatt R; Waite DE; Waite PD; Laskin DM; Smith ST

1988-10-01

55

Therapeutic effects of alpha lipoic acid and vitamin C on alveolar bone resorption after experimental periodontitis in rats: a biochemical, histochemical, and stereologic study.  

UK PubMed Central (United Kingdom)

BACKGROUND: Alpha lipoic acid (ALA) and vitamin C (Vit-C) are very important and powerful antioxidants that have been used for the treatment of many diseases. The present study aims to investigate the role of ALA and Vit-C substances in the treatment of alveolar bone resorption in periodontal diseases. METHODS: Thirty-six male Wistar albino rats were randomly divided into four groups as follows: 1) control rats; 2) rats with experimental periodontitis (PED); 3) rats with PED treated with ALA (ALA); and 4) rats with PED treated with ALA+Vit-C (ALA+Vit-C). PED was simulated by placing ligatures around the neck of teeth for 5 weeks. After ligature removal, the PED group was given a single intragastric dose of 1 mL saline, and the ALA and ALA+Vit-C groups were treated with an intragastric dose of 50 mg/kg ALA and ALA+Vit-C for 15 days, respectively. Levels of serum bone alkaline phosphatase (B-ALP) and myeloperoxidase (MPO) activity in gingival tissues were analyzed. To evaluate the osteoclast activation, expression of activated receptor activator nuclear factor-kappa B ligand (RANKL) and bone density index (BDI) were determined stereologically in the bone sections obtained from the mandibles of the rats. RESULTS: The results showed statistically significant differences between the PED group and groups treated with antioxidant according to B-ALP, MPO, RANKL, and BDI values (P <0.05). ALA and ALA+Vit-C treatments showed beneficial effects on the mesial/distal periodontal bone support at the ligature-induced periodontitis tooth areas. CONCLUSION: This study shows that ALA and Vit-C treatment provides therapeutic effects on inhibition of alveolar bone resorption and periodontal tissue destruction.

Akman S; Canakci V; Kara A; Tozoglu U; Arabaci T; Dagsuyu IM

2013-05-01

56

Regeneración ósea guiada para el aumento vertical del reborde alveolar/ Guided osseous regeneration for the vertical augmentation of the alveolar ridge  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Se considera como aumento óseo vertical, cualquier técnica que apunte a crear una mayor altura del reborde alveolar. A inicios de la década de los 90’s se empezó a utilizar la regeneración ósea guiada (ROG) en mandíbulas atróficas, con el fin de permitir la instalación de implantes óseointegrados. Con el fin de evaluar y exponer parte de la evidencia disponible en la actualidad, con respecto a la ROG para aumento óseo vertical, se realizó la siguiente revisión bibliográfica. Abstract in english Any technique aimed to improve the alveolar ridge height is considered as a vertical bone augmentation procedure. In the early 90’s guided bone regeneration (GBR) procedures began to be used in atrophic mandibles to allow the installation of osseointegrated dental implants. The following bibliographic review was made with the purpose of evaluating and exposing part of the available evidence at present in this field.

Nappe, CE; Baltodano, CE

2013-04-01

57

Computed tomographic evaluation of alterations of the buccolingual width of the alveolar ridge after immediate implant placement associated with the use of a synthetic bone substitute.  

UK PubMed Central (United Kingdom)

PURPOSE: To evaluate the alterations of the buccolingual width of the alveolar ridge after immediate implant placement using a fully synthetic biphasic calcium phosphate (BCP) consisting of a mixture of 60% hydroxyapatite and 40% ?-tricalcium phosphate in esthetic regions. MATERIALS AND METHODS: The buccolingual widths of the alveolar ridge in 20 extraction sites in 20 patients were assessed using computed tomography. Measurements were performed before and 6 months after extractions and immediate implant placement. In group 1 (11 patients), BCP was in the space between the buccal wall of the alveolar ridge and implant. In group 2 (9 patients), the same evaluations and procedures were performed but without using BCP. RESULTS: The buccolingual dimensions of the alveolar ridge in group 1 (BCP) showed no significant preoperative differences (8.49 ± 1.1 mm) during the 6-month period after surgery (8.82 ± 0.9 mm) (P = .14). In group 2, the differences in buccolingual dimensions of the alveolar ridge were statistically significant (P = .01) with reduction in dimensions from 8.12 ± 0.7 mm during the preoperative period to 7.01 ± 0.4 mm 6-months after surgery. CONCLUSION: The use of BCP was effective in preserving buccolingual dimensions of alveolar ridges in immediate implant surgeries.

Assaf JH; Zanatta FB; de Brito RB Jr; França FM

2013-05-01

58

Alveolar ridge augmentation: combining bioresorbable scaffolds with osteoinductive bone grafts in atrophic sites. A follow-up to an evolving technique.  

UK PubMed Central (United Kingdom)

When a tooth or teeth are lost, the 3-dimensional (3-D) atrophy of alveolar ridges predictably ensues. This commonly precludes placement of dental implants, or at least complicates their insertion into favorable positions. Numerous methods of alveolar ridge augmentation have evolved, including blocks of autogenous bone-harvested from intra- and extraoral sources- being fixed to the resorbed ridge, and particulate grafts of autogenous, allogeneic, xenograft, or alloplasts, which are often combined with barrier membranes (guided bone regeneration GBR). Ridge-splitting techniques, where the narrow bone is fractured in a green-stick manner--often combined with exogenous grafts and GBR--is also commonly performed. This article will demonstrate a technique where a resorbable mesh (PLGA) is combined with an osteoinductive protein (rhBMP-2) and a readily acquired bone allograft (FDBA) to reconstruct severely resorbed alveolar ridges to facilitate prosthetically guided implant placement.

Levin BP

2013-03-01

59

Collagen/hydroxylapatite implant for augmenting deficient alveolar ridges: twelve-month clinical data.  

Science.gov (United States)

In a multicenter study, 77 edentulous patients had mandibular augmentation with implants of purified fibrillar collagen combined with dense hydroxylapatite (Alveoform Biograft); 22 of these patients also had maxillary augmentation. Most patients had Class III or IV mandibular atrophy, and had outpatient surgery with the subperiosteal tunneling technique. Temporary splints were worn for 24 hours post-surgery. Mean ridge height was 15.3 mm before surgery and 19.5 mm after 12 months, an augmentation of 4.2 mm. Predictable compaction occurred largely in the first few months after denture loading. Most patients, surgeons, and prosthodontists assessed the results of the procedure as good to excellent at 1 year following implantation. Adverse experiences, largely dehiscence and paresthesia, tended to resolve over time. Sera from ten patients demonstrated antibodies to bovine collagen that were not clinically significant. Alveolar augmentation with collagen/hydroxylapatite achieved clinically significant results that compared favorably with those achieved with other types of ceramic implants. PMID:2845038

Mehlisch, D R; Taylor, T D; Leibold, D G; Hiatt, R; Waite, D E; Waite, P D; Laskin, D M; Smith, S T

1988-10-01

60

Efficacy of Enamel Matrix Derivative on Alveolar Ridge Augmentation by Distraction Osteogenesis  

Directory of Open Access Journals (Sweden)

Full Text Available Distraction osteogenesis (DO) is a surgical-orthopedic technique for lengthening a bone by separating or distracting a fractured callus. The aim of this study was to observe the effects of an enamel matrix derivative (EMD) on bone repair and regeneration after DO on a canine mandible. Ten adult beagle dogs were used in this study. Their right and left mandibles were compared as the test and control groups, respectively. The distraction was undertaken at a rate of 1 mm per day for 10 consecutive days to yield 10 mm lengthening of the mandibular corpus. The EMD was treated into the test group at the site of the lengthened bone. At 0, 1, 3, 6 and 9 weeks after EMD treatment, the bone mineral density (BMD) at the site of the lengthened bone was measured using quantitative computed tomography. BMD in the tested group was higher during consolidation period than in the control. The difference in the BMD of 1 and 3 weeks after EMD treatment was significant (p < 0.05). In histological findings, new bone formation in the test group was denser than the control group. These results suggest that the application of an EMD during DO is suitable method for alveolar ridge augmentation in dogs.

J.M. Kim, J.H. Kim, T.S. Han, G. Kim, S.S. Kang1 and S.H. Choi*

2011-01-01

 
 
 
 
61

Anthropometric Measurements in Toothed and Toothless Maxillaries and its Consequences in Human Alveolar Bone Resorption/ Mediciones Antropométricas en Maxilares con y sin Dientes de Humanos y sus Consecuencias en la Reabsorción Ósea Alveolar  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Este estudio propuso medir y comparar las medidas antropométricas entre los maxilares con y sin dientes. Fueron utilizados 26 cráneos humanos, 13 maxilares con dientes y 13 sin dientes. Las mediciones fueron realizadas a ambos lados por dos evaluadores entre las distancias del reborde alveolar (RA): a la espina nasal anterior (ENA), al canal incisivo (CI) y a lo foraámenes palatinos mayor (FPMA) y menor (FPME). Los datos mostraron que la media de las mediciones fueron (more) proporcionalmente mayores en las maxilas con dientes, para todas las mediciones en cualquiera de los evaluadores. El RA-ENA (p = 0,001), AR-CI (p = 0,006), RA-APMA derecho (p = 0,001) y RA-APMA izquierdo (p Abstract in english This study proposes to measure and compare anthropometric measurements between toothed and toothless maxillas. 26 human skulls were used with: 13 toothed and 13 toothless maxillas. The measurements were made between the distances of the alveolar ridge (AR): the anterior nasal spine (ANS), to the incisive foramen (FI) and the palatine foramen, greater (FPMA) and lower (FPME) on both sides by two evaluators. The data obtained showed that the average of the measurements were (more) correspondingly higher in toothed maxillas than in toothless, for all measurements in any one of the evaluators. The AR-ANS (p = 0.001), IF-AR (p = 0.006), AR-FPMA right (p = 0.001) and AR-FPMA left (p

de Oliveira, Jaciel Benedito; Almeida, Andrelle Nayara Cavalcanti Lima de; Lins, Carla Cabral dos Santos Accioly; Júnior, Adelmar Afonso de Amorim; Seixas, Zélia Albuquerque

2012-09-01

62

The influence of the alveolar ridge shape on the stress distribution in a free-end saddle removable partial denture supported by implant.  

Science.gov (United States)

The alveolar ridge shape plays an important role in predicting the demand on the support tooth and alveolar bone in the removable partial denture (RPD) treatment. However, these data are unclear when the RPD is associated with implants. This study evaluated the influence of the alveolar ridge shape on the stress distribution of a free-end saddle RPD partially supported by implant using 2-dimensioanl finite element analysis (FEA). Four mathematical models (M) of a mandibular hemiarch simulating various alveolar ridge shapes (1-distal desceding, 2-concave, 3-horizontal and 4-distal ascending) were built. Tooth 33 was placed as the abutment. Two RPDs, one supported by tooth and fibromucosa (MB) and other one supported by tooth and implant (MC) were simulated. MA was the control (no RPD). The load (50N) were applied simultaneously on each cusp. Appropriate boundary conditions were assigned on the border of alveolar bone. Ansys 10.0 software was used to calculate the stress fields and the von Mises equivalent stress criteria (sigmavM) was applied to analyze the results. The distal ascending shape showed the highest sigmavM for cortical and medullar bone. The alveolar ridge shape had little effect on changing the sigmavM based on the same prosthesis, mainly around the abutment tooth. PMID:22165315

Júnior, Manoel M; Anchieta, Rodolfo B; Rocha, Eduardo P; Pereira, João A; Archangelo, Carlos M; Freitas-Júnior, Amilcar C; Almeida, Erika O

2011-01-01

63

Carcinoma de células escamosas em rebordo alveolar inferior: diagnóstico e tratamento odontológico de suporte Squamous cell carcinoma in lower alveolar ridge: diagnosis and odontologic support treatment  

Directory of Open Access Journals (Sweden)

Full Text Available O carcinoma epidermóide é a neoplasia maligna mais comum de cavidade oral e estruturas adjacentes. Apresenta maior incidência no gênero masculino, após a quarta década de vida, e tem como principais fatores etiológicos os usos crônicos de tabaco e álcool. Neste trabalho é relatado um caso de carcinoma de células escamosas do rebordo alveolar inferior, que não é uma região preferencial para esse tipo de patologia. Também é discutida a importância do cirurgião-dentista na equipe de profissionais que assiste esses pacientes, tanto no diagnóstico precoce quanto no manejo das alterações estomatológicas advindas da terapia antineoplásica.Squamous cell carcinoma is the most common malignant neoplasm in oral cavity and adjacent structures. Its prevalence is higher in males, after the fourth decade, and the main etiologic associated factors are smoking and alcohol. This study reports a case of squamous cell carcinoma arising from the lower alveolar ridge, a non-preferential site for this pathology. It also discusses the importance of the dentist in the team of professionals assisting these patients, in early diagnosis and treatment of the stomatological alterations due to antineoplastic therapy.

Filipe Ivan Daniel; Rodrigo Granato; Liliane Janete Grando; Sônia Maria Lückmann Fabro

2006-01-01

64

Carcinoma de células escamosas em rebordo alveolar inferior: diagnóstico e tratamento odontológico de suporte/ Squamous cell carcinoma in lower alveolar ridge: diagnosis and odontologic support treatment  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese O carcinoma epidermóide é a neoplasia maligna mais comum de cavidade oral e estruturas adjacentes. Apresenta maior incidência no gênero masculino, após a quarta década de vida, e tem como principais fatores etiológicos os usos crônicos de tabaco e álcool. Neste trabalho é relatado um caso de carcinoma de células escamosas do rebordo alveolar inferior, que não é uma região preferencial para esse tipo de patologia. Também é discutida a importância do cirurg (more) ião-dentista na equipe de profissionais que assiste esses pacientes, tanto no diagnóstico precoce quanto no manejo das alterações estomatológicas advindas da terapia antineoplásica. Abstract in english Squamous cell carcinoma is the most common malignant neoplasm in oral cavity and adjacent structures. Its prevalence is higher in males, after the fourth decade, and the main etiologic associated factors are smoking and alcohol. This study reports a case of squamous cell carcinoma arising from the lower alveolar ridge, a non-preferential site for this pathology. It also discusses the importance of the dentist in the team of professionals assisting these patients, in early diagnosis and treatment of the stomatological alterations due to antineoplastic therapy.

Daniel, Filipe Ivan; Granato, Rodrigo; Grando, Liliane Janete; Fabro, Sônia Maria Lückmann

2006-08-01

65

Evaluation of alveolar ridge bend and length in upper and lower jaws in anthropological skulls for planning of a series of endosseous dental implants.  

UK PubMed Central (United Kingdom)

The alveolar ridge bend and length were measured in the interforaminal part of the upper and lower jaws in 338 anthropological skulls. Interforaminal sections were determined by projection of the most medial points of the two foramina infraorbitale and foramina mentale at right angles to the alveolar ridge bends. Interforaminal arch lengths and radii of the circles that best fit the arches were analyzed with the use of celluloid transparencies. The differences between female and male group samples and the left and right sides were established. The data were processed by computer and were used for the development of a series of endosseous dental implants to satisfy various anatomical conditions.

Ponyi S; Szabó G; Divinyi T

1991-07-01

66

Management of the maxilla after alveolar ridge augmentation with hydroxylapatite when opposed by mandibular implants.  

Science.gov (United States)

Maxillary ridge augmentation and vestibuloplasty are often adjuncts to mandibular implant reconstructions. Careful management of the augmented ridge after surgery is critical to the success of the maxillary prosthesis and osseointegration of the mandibular implant. A technique is described for alteration of an existing maxillary complete denture after ridge augmentation. Precautions regarding prosthesis function during the osseointegration phase of different types of mandibular reconstructions are noted. Technique and rationale for denture flange modification when a prosthesis is rebased for a patient who received simultaneous vestibuloplasty and ridge augmentation are described. PMID:9227098

Gates, W D; Scurria, M S; Terry, B C

1994-06-01

67

Management of the maxilla after alveolar ridge augmentation with hydroxylapatite when opposed by mandibular implants.  

UK PubMed Central (United Kingdom)

Maxillary ridge augmentation and vestibuloplasty are often adjuncts to mandibular implant reconstructions. Careful management of the augmented ridge after surgery is critical to the success of the maxillary prosthesis and osseointegration of the mandibular implant. A technique is described for alteration of an existing maxillary complete denture after ridge augmentation. Precautions regarding prosthesis function during the osseointegration phase of different types of mandibular reconstructions are noted. Technique and rationale for denture flange modification when a prosthesis is rebased for a patient who received simultaneous vestibuloplasty and ridge augmentation are described.

Gates WD; Scurria MS; Terry BC

1994-06-01

68

Maxillary alveolar ridge reconstruction with monocortical fresh-frozen bone blocks: a clinical, histological and histomorphometric study.  

UK PubMed Central (United Kingdom)

BACKGROUND: This investigation is a clinical and histological assessment of fresh-frozen bone use in the reconstruction of maxillary alveolar ridges. The study evaluates the effectiveness of this material as a bone filler prior the placement of dental implants. PATIENTS AND METHODS: Sixteen patients with atrophic maxillary ridges underwent maxillary reconstruction with fresh-frozen tibial human block grafts prior to implant placement. Sampling procedures were carried out 4, 6 and 9 months later when a bone core was removed from the grafts for histological and histomorphometric analysis. RESULTS: Eighteen blocks were placed, and each patient received either 1 or 2 blocks. During the sampling procedures, all of the grafts were found to be firm in consistency, well-incorporated, and vascularized. A total of 34 implants were placed into the grafts with a minimum of 40-Newton-cm torque in all cases. The follow-up period ranged from 18 to 30 months. No implants were lost. The histological analysis revealed vital bone with mature and compact osseous tissue surrounded by marrow spaces. CONCLUSION: Bone allografts can be used successfully as graft material for the treatment of maxillary ridge defects. This type of bone graft can be used safely in the areas of implant placement as a suitable alternative to autogenous grafts.

Acocella A; Bertolai R; Ellis E 3rd; Nissan J; Sacco R

2012-09-01

69

Altered position of the medial lingual nutritional foramina in the different stages of alveolar ridge atrophy.  

UK PubMed Central (United Kingdom)

Abstract To determine the altered location of the medial lingual nutritional foramina in different stages of bone resorption, 1532 cadaveric mandibles were investigated. Prevalence, location of the foramen (lingual/cranial/labial), application of Atwood classification (grades 1-6), and macro-anatomical dissections were tools of this examination. An increasing grade of atrophy leads to a shift in position of the medial lingual nutritional foramen.

Lautner NV; Krenkel C; Gaggl A; Bernauer E

2011-11-01

70

A technique for impressing the severely resorbed mandibular edentulous ridge.  

UK PubMed Central (United Kingdom)

Patients presenting with severe resorption of the residual alveolar ridges are relatively common today in both private practices and teaching institutions. The severely resorbed mandibular ridge is more challenging to impress than is the maxillary ridge. Accurately capturing the denture-bearing surface in its entirety is crucial to providing the patient with a functionally successful prosthesis. This article presents a technique to overcome the difficulties encountered in impressing the severely resorbed mandibular ridge using elastomeric impression materials and a modified special custom tray.

Chandrasekharan NK; Kunnekel AT; Verma M; Gupta RK

2012-04-01

71

[Ridge preservation after tooth extraction: what do we know today].  

UK PubMed Central (United Kingdom)

Following tooth removal, varying amounts of bone resorption take place due to qualitative and quantitative changes that occur at the alveolar bone around the extraction site. Alveolar bone is a tooth dependent structure and therefore, after a tooth is extracted, dimensional bone reduction takes place both, horizontally and vertically resulting in changes that may lead to esthetic and functional problems. Such deformities of the alveolar ridge may compromise future implant placement as well as esthetic results when a fixed partial denture is constructed in a visible area. In order to preserve ridge dimensions following tooth extraction, particularly where future implant placement is planned, ridge/socket preservation is recommended. Ridge/socket preservation is any procedure undertaken at the time of or following an extraction that is designed to minimize external resorption of the ridge and maximize bone formation within the socket. In certain situations it not advisable to perform ridge preservation at the time of tooth extraction thus, preservation is delayed by few weeks (6-8). This paper reviews the various socket/ridge preservation techniques and the diverse materials used to fill those deficient tissues or prevent their collapse. Scientific literature review is discussed.

Chackartchi T; Stabholz A

2013-04-01

72

Culture and identification of human bone marrow mesenchymal stem cells from alveolar ridge dental implant site.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective of this study was to establish the culture method of human bone marrow mesenchymal stem cells (BMSCs) from alveolar bone marrow. METHODS: Alveolar bone marrow complex samples were obtained from 35 patients, 22 to 65 years of age, during the course of dental implant treatment by low-speed method. Bone marrow mesenchymal stem cells were seeded and maintained in culture with 10% fetal bovine serum. The form of the cultured cells was observed under inverted microscope, and the cell proliferation capacity was detected. Cell cycle and the antigen expression of P3 BMSCs were measured with flow cytometry. RESULTS: From a small volume (about 0.1-0.2 mL) of bone marrow complex, alveolar BMSCs expanded at a success ratio of 29 (83%) of 35. There is dysmorphism in cultured cells, which mainly were long spindle, polygon, and triangle. Flow cytometry instrument test showed that the cells in G0/G1 phase were an average of 79.29% ± 1.70% and in S phase were an average of 11.09% ± 0.87%. For antibody expression rate: CD29 is 88.00% ± 1.56%, CD44 is 88.15% ± 1.64%, CD34 is 0.42% ± 0.10%, CD45 is 0.45% ± 0.12%, and CD11b is 0.45% ± 0.14%. CONCLUSION: The cells of the marrow complex obtained by low-speed method in implant site preparation cultured in vitro were identified as BMSCs through the morphological observation and the flow cytometry. It is a kind of feasible and simple culture method of human primary BMSCs.

Ye J; Gong P; Zhou F; Li G; Ye C; Sung H; Mo A

2013-09-01

73

Internal resorption.  

Science.gov (United States)

Internal resorption is a relatively rare resorption of dentine, which starts in the pulpal cavity either in the pulpal chamber or in the root canal and destroys surrounding dental hard tissues. The initiating factor in internal root resorption is thought to be trauma or chronic pulpal inflammation, but other aetiological factors have also been suggested. The prognosis for treatment of small lesions of internal resorption is good. However, if the tooth structure is greatly weakened and perforation has occurred, the prognosis is poor and tooth extraction must be considered. In this article we report a rare case of internal resorption in a 26-year-old male patient. PMID:23845670

Mohan, Ravi Prakash Sasankoti; Verma, Sankalp; Singh, Udita; Agarwal, Neha

2013-07-10

74

Alveolar ridge preservation after dental extraction and before implant placement: a literature review/ Preservação do rebordo alveolar após a extração dentária e antes da colocação de implante: revisão da literatura  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Várias técnicas e materiais têm sido sugeridos para a preservação do rebordo alveolar (PRA) após a extração dentária e antes da colocação do implante. Esta revisão de literatura buscou discutir os aspectos histológicos e clínicos da cicatrização do alvéolo e do procedimento PRA após a extração dentária e verificar se ele permite a colocação de implante dentário (com ou sem enxerto adicional). Apesar da heterogeneidade dos estudos, há evidência qu (more) e os procedimentos de preservação do rebordo são eficazes na limitação da perda dimensional do rebordo pós-extração e são acompanhados por um grau diferente de regeneração óssea, com variadas quantidades de partículas residuais dos "materiais de enxerto". Abstract in english Several techniques and materials have been suggested for alveolar ridge preservation (ARP) after dental extraction and before implant placement. This literature review aimed to discuss the histological and clinical aspects of alveolar healing and the ARP procedure after dental extraction and to verify whether it allows dental implant placement (with or without further augmentation). Despite the heterogeneity of the studies, some evidence suggests that ridge preservation p (more) rocedures are efficient in limiting the postextraction dimensional loss of the ridge and are accompanied by a different degree of bone regeneration, with varied amounts of residual graft material particles.

Mezzomo, Luis André; Shinkai, Rosemary Sadami; Mardas, Nikos; Donos, Nikolaos

2011-01-01

75

Orthopantomographic study of the alveolar bone level on periodontal disease  

International Nuclear Information System (INIS)

The author had measured the alveolar bone level of periodontal disease on 50 cases of orthopantomogram to detect the degree of alveolar bone resorption of both sexes of Korean. The results were obtained as follows; 1. Alveolar bone resorption of mesial and distal portion was similar in same patient. 2. The order of alveolar bone resorption was mandibular anterior region, posterior region, canine and premolar region of both jaws. 3. The degree of alveolar bone destruction was severe in shorter root length than longer one. 4. The degree of alveolar bone resorption was severe in fourth decades.

1972-01-01

76

A methodological approach to assessing alveolar ridge preservation procedures in humans: soft tissue profile.  

UK PubMed Central (United Kingdom)

INTRODUCTION: The aesthetic results of implant restoration in the anterior maxilla are particularly related to the soft tissue profile. Although socket preservation techniques appear to reduce bone remodelling after tooth extraction, there is still few investigations assessing the external soft tissue profile after such procedures. The goal of this study was to describe an accurate technique to evaluate soft tissue contour changes after performing socket preservation procedures. The secondary objective was to apply the newly developed measuring method to a specific socket preservation using a "saddled" connective tissue graft combined with the insertion of slowly resorbable biomaterials into the socket. MATERIALS AND METHODS: A total of 14 patients needing tooth replacement in the aesthetic region were included to receive a socket preservation procedure using a connective tissue graft. Impressions were taken before the tooth extraction (baseline) and at 2, 4, and 12 weeks after the procedure. The corresponding plaster casts were scanned, and the evolution of the soft tissue profile in relation to the baseline situation was assessed using imaging software. RESULTS: The measuring technique allowed assessing the soft tissue profiles accurately at different levels of the alveolar process. The insertion of a saddled connective tissue appeared to compensate for the horizontal and vertical bone remodelling after a socket preservation procedure in most regions of the alveolar crest. After 12 weeks, the only significant change was located in the more cervical and central region of the alveolar process and reached a median drop of 0.62 mm from baseline. CONCLUSION: Within the limitations of this study, we found that a saddled connective tissue graft combined with a socket preservation procedure could almost completely counteract the bone remodelling in terms of the external soft tissue profile. The minor changes found in the cervical region might disappear with the emergence profile of the prosthodontic components. The described technique might therefore enhance the aesthetic outcomes when a tooth has to be replaced in the aesthetic zone. The described protocol can be used to further compare the effectiveness of different extraction socket preservation protocols in randomised controlled trials.

Vanhoutte V; Rompen E; Lecloux G; Rues S; Schmitter M; Lambert F

2013-04-01

77

Dental implants placed on bone subjected to vertical alveolar distraction show the same performance as those placed on primitive bone  

Science.gov (United States)

Introduction: Vertical osteogenic alveolar distraction (VOAD) allows for the augmentation of the alveolar ridge for the placement of dental implants in atrophic alveolar ridges. The goal of this paper is to assess long-term peri-implant bone resorption in implants placed on bones subjected to VOAD, comparing it with a group of patients who had implants placed directly on the alveolar bone without previous bone regeneration. Material and Methods: We conducted a follow-up study on 32 patients who were divided into two groups: The Distraction Group (14 patients), and the Distraction-Free Group (18 patients), who received a total of 100 implants. Peri-implant bone loss was measured by means of panoramic X-rays, at the time of loading and one year later, and in 35 implants of each group after 3 years of functional loading. Results: The peri-implant bone resorption (PBR) average observed in the Distraction Group at the time of prosthetic placement is higher (0.50±0.09 mm) than in the Distraction-Free Group (0.25±0.06 mm), showing statistically significant results (p=0.047). PBR levels 1 year after loading were the same for both groups (0.66 mm). At 3 years, they were higher in the Distraction Group (1.03 ± 0.22 mm vs. 0.68 ± 0.08 mm). Key words:Bone resorption, alveolar distraction osteogenesis, dental implants.

Leon-Camacho, Maria A.; Somoza-Martin, Jose M.; Fernandez-Gonzalez, Beatriz; Blanes-Vazquez-Gundin, Silvia; Gandara-Rey, Jose M.; Garcia-Garcia, Abel

2013-01-01

78

Fate of autologous and fresh-frozen allogeneic block bone grafts used for ridge augmentation. A CBCT-based analysis.  

UK PubMed Central (United Kingdom)

OBJECTIVES: To evaluate dimensional changes in autologous (AT) and fresh-frozen allogeneic (AL) block bone grafts 6 months after alveolar ridge augmentation. MATERIAL AND METHODS: Twenty-six partially or totally edentulous patients treated either with fresh-frozen AL bone or AT bone onlay block grafts prior to implant placement (13 patients in each group), were included in this analysis. Patients received CBCT (i-CAT Classic) examinations prior to surgery and 14 days and 6 months after grafting. Differences in alveolar ridge area among the various observation times were evaluated by planimetric measurements on two-dimensional CBCT images of the grafted regions. Nineteen grafted blocks from each group were evaluated. RESULTS: Significant increase in alveolar ridge dimensions, allowing implant placement, was obtained with both types of grafts 6 months after grafting; no significant differences in alveolar ridge area were observed between the groups at the various observation times. However, graft resorption in the AL group was significantly larger compared to that in the AT group at 6 months. CONCLUSIONS: Larger bone graft resorption was seen in patients treated with fresh-frozen AL bone than in those treated with AT bone 6 months following alveolar ridge augmentation.

Spin-Neto R; Stavropoulos A; Dias Pereira LA; Marcantonio E Jr; Wenzel A

2013-02-01

79

Fate of autologous and fresh-frozen allogeneic block bone grafts used for ridge augmentation. A CBCT-based analysis  

DEFF Research Database (Denmark)

OBJECTIVES: To evaluate dimensional changes in autologous (AT) and fresh-frozen allogeneic (AL) block bone grafts 6 months after alveolar ridge augmentation. MATERIAL AND METHODS: Twenty-six partially or totally edentulous patients treated either with fresh-frozen AL bone or AT bone onlay block grafts prior to implant placement (13 patients in each group), were included in this analysis. Patients received CBCT (i-CAT Classic) examinations prior to surgery and 14 days and 6 months after grafting. Differences in alveolar ridge area among the various observation times were evaluated by planimetric measurements on two-dimensional CBCT images of the grafted regions. Nineteen grafted blocks from each group were evaluated. RESULTS: Significant increase in alveolar ridge dimensions, allowing implant placement, was obtained with both types of grafts 6 months after grafting; no significant differences in alveolar ridge area were observed between the groups at the various observation times. However, graft resorption in the AL group was significantly larger compared to that in the AT group at 6 months. CONCLUSIONS: Larger bone graft resorption was seen in patients treated with fresh-frozen AL bone than in those treated with AT bone 6 months following alveolar ridge augmentation.

Spin-Neto, Rubens; Stavropoulos, Andreas

2013-01-01

80

Diets Based on Virgin Olive Oil or Fish Oil but Not on Sunflower Oil Prevent Age-Related Alveolar Bone Resorption by Mitochondrial-Related Mechanisms  

Science.gov (United States)

Background/Objectives Aging enhances frequency of chronic diseases like cardiovascular diseases or periodontitis. Here we reproduced an age-dependent model of the periodontium, a fully physiological approach to periodontal conditions, to evaluate the impact of dietary fat type on gingival tissue of young (6 months old) and old (24 months old) rats. Methods/Findings Animals were fed life-long on diets based on monounsaturated fatty acids (MUFA) as virgin olive oil, n-6 polyunsaturated fatty acids (n-6PUFA), as sunflower oil, or n-3PUFA, as fish oil. Age-related alveolar bone loss was higher in n-6PUFA fed rats, probably as a consequence of the ablation of the cell capacity to adapt to aging. Gene expression analysis suggests that MUFA or n-3PUFA allowed mitochondria to maintain an adequate turnover through induction of biogenesis, autophagy and the antioxidant systems, and avoiding mitochondrial electron transport system alterations. Conclusions The main finding is that the enhanced alveolar bone loss associated to age may be targeted by an appropriate dietary treatment. The mechanisms involved in this phenomenon are related with an ablation of the cell capacity to adapt to aging. Thus, MUFA or n-3PUFA might allow mitochondrial maintaining turnover through biogenesis or autophagy. They might also be able to induce the corresponding antioxidant systems to counteract age-related oxidative stress, and do not inhibit mitochondrial electron transport chain. From the nutritional and clinical point of view, it is noteworthy that the potential treatments to attenuate alveolar bone loss (a feature of periodontal disease) associated to age could be similar to some of the proposed for the prevention and treatment of cardiovascular diseases, a group of pathologies recently associated with age-related periodontitis.

Bullon, Pedro; Battino, Maurizio; Varela-Lopez, Alfonso; Perez-Lopez, Patricia; Granados-Principal, Sergio; Ramirez-Tortosa, Maria C.; Ochoa, Julio J.; Cordero, Mario D.; Gonzalez-Alonso, Adrian; Ramirez-Tortosa, Cesar L.; Rubini, Corrado; Zizzi, Antonio; Quiles, Jose L.

2013-01-01

 
 
 
 
81

Diets based on virgin olive oil or fish oil but not on sunflower oil prevent age-related alveolar bone resorption by mitochondrial-related mechanisms.  

UK PubMed Central (United Kingdom)

BACKGROUND/OBJECTIVES: Aging enhances frequency of chronic diseases like cardiovascular diseases or periodontitis. Here we reproduced an age-dependent model of the periodontium, a fully physiological approach to periodontal conditions, to evaluate the impact of dietary fat type on gingival tissue of young (6 months old) and old (24 months old) rats. METHODS/FINDINGS: Animals were fed life-long on diets based on monounsaturated fatty acids (MUFA) as virgin olive oil, n-6 polyunsaturated fatty acids (n-6PUFA), as sunflower oil, or n-3PUFA, as fish oil. Age-related alveolar bone loss was higher in n-6PUFA fed rats, probably as a consequence of the ablation of the cell capacity to adapt to aging. Gene expression analysis suggests that MUFA or n-3PUFA allowed mitochondria to maintain an adequate turnover through induction of biogenesis, autophagy and the antioxidant systems, and avoiding mitochondrial electron transport system alterations. CONCLUSIONS: The main finding is that the enhanced alveolar bone loss associated to age may be targeted by an appropriate dietary treatment. The mechanisms involved in this phenomenon are related with an ablation of the cell capacity to adapt to aging. Thus, MUFA or n-3PUFA might allow mitochondrial maintaining turnover through biogenesis or autophagy. They might also be able to induce the corresponding antioxidant systems to counteract age-related oxidative stress, and do not inhibit mitochondrial electron transport chain. From the nutritional and clinical point of view, it is noteworthy that the potential treatments to attenuate alveolar bone loss (a feature of periodontal disease) associated to age could be similar to some of the proposed for the prevention and treatment of cardiovascular diseases, a group of pathologies recently associated with age-related periodontitis.

Bullon P; Battino M; Varela-Lopez A; Perez-Lopez P; Granados-Principal S; Ramirez-Tortosa MC; Ochoa JJ; Cordero MD; Gonzalez-Alonso A; Ramirez-Tortosa CL; Rubini C; Zizzi A; Quiles JL

2013-01-01

82

Evaluación radiográfica de aumentos de rebordes alveolares con injertos aloplásticos de hidroxiapatita no reabsorbible: seguimiento a nueve meses Radiographic evaluation of alveolar ridge augmentation with non resorbable hydroxyapatite alloplastic grafts: nine months follow up  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUCCIÓN: el objetivo fue determinar radiográficamente el porcentaje de estabilidad de la altura del reborde alveolar del maxilar superior e inferior en pacientes sometidos a cirugía preprotésica de aumento de reborde con implante de HA no reabsorbible. MÉTODOS: el estudio se realizó en quince pacientes, en quienes se determinaron mediciones reproducibles. Para el maxilar superior: (A) desde espina nasal anterior; (B derecha-izquierda) desde el borde más inferior de las fosas nasales; (C derecha- izquierda) desde el borde más inferior de la órbita. Para el maxilar inferior: (E) desde el borde inferior de la mandíbula y pasando por la sínfisis; (F derecha-izquierda) pasando por el agujero mentoniano; (G derecha-izquierda) pasando 5 mm. atrás del agujero mentoniano; (H derecha-izquierda) pasando 10 mm posterior al agujero mentoniano. Todas las mediciones se realizaron en el prequirúrgico, en el posquirúrgico inmediato, y a los nueve meses. RESULTADOS: se promediaron los diferentes puntos del maxilar superior (PPMXS) y se observó una pérdida de altura entre el 6,29 y un 33,6% con promedio del 17,36 %. En el maxilar inferior (PPMXI) se observó una variación desde ganancia del 6,31% hasta una disminución del 18,87%, con promedio del 2,54%. CONCLUSIONES: el implante de HA permite restablecer adecuada altura del reborde alveolar. La altura del reborde alveolar obtenida inicialmente presenta un porcentaje de disminución de su altura en el maxilar superior del 17,36%, y en el maxilar inferior del 2,54 durante el seguimiento a nueve meses.INTRODUCTION: the purpose of this study was to determine radiographically the percentage of stability of alveolar ridge height in the maxilla and the mandible in patients subjected to pre prosthetic surgery of ridge augmentation with non resorbable HA implants. METHODS: the study was performed in 15 patients in whom reproducible measurements were taken. For the maxilla: (A) From Anterior Nasal Spine; (B right and left) from the lowest border of the nasal fossae; (C right and left) from the lowest border of the orbit. For the mandible: (E) from the lowest border of the mandible passing through symphysis; (F right and left) passing through the mental foramen; (G right and left) passing 5 mm posterior to the mental foramen; (H right and left) passing 10 mm posterior to mental foramen. All measurements were performed before surgery, immediately after and, nine months after surgery. RESULTS: the different points of the maxilla were averaged (PPMXS) and a height loss between 6.29% and 33.6% was observed, with an average of 17.36%. For the mandible (PPMXL) variations ranging from 6.31% of augmentation to 18.8% loss were observed, with an average of 2.54%. CONCLUSIONS: HA implants allow reestablishment of adequate alveolar ridge height. The alveolar ridge height initially obtained presents a decrease percentage in height for the maxilla of 17.36% and 2.54% for the mandible after nine months follow up.

Félix Antonio Gil Cárdenas

2008-01-01

83

The effect of covering materials with an open wound in alveolar ridge augmentation using beta-tricalcium phosphate: an experimental study in the dog.  

UK PubMed Central (United Kingdom)

PURPOSE: This study aimed to examine the effectiveness of a grafting technique using beta-tricalcium phosphate (?-TCP) covered with different materials in alveolar bone defects with dehiscences. MATERIALS AND METHODS: In five beagle dogs, all premolars in the mandible were extracted bilaterally. After a 12-week healing period, two bone defects (length, 5 mm; width, 5 mm; depth, 7 mm) were created on each side of the mandible, and the buccal bone plate was resected. The four bone defects were randomly assigned to one of the following treatments: group 1, ?-TCP alone (TCP group); group 2, ?-TCP graft covered with collagen sponge (TCP+collagen group); group 3, ?-TCP graft covered with free buccal mucosa (TCP+mucosa group); group 4, no treatment (control group). The microarchitecture of the regenerated bone was observed using microcomputed tomography, and the area of newly formed bone was measured. Specimens from each defect were selected and subjected to histologic and histomorphometric analysis; areas of newly formed bone and the ridge width were measured in the specimens. RESULTS: Significant differences were found between the control group and all test groups. The median horizontal width of the ridge 2 mm from the top of the alveolar crest in the TCP+mucosa group was significantly greater than that of the TCP group. There was no significant difference between the TCP+mucosa and TCP+collagen groups in any measurement. CONCLUSIONS: Application of ?-TCP grafts to alveolar bone defects with dehiscence and covering of the open wound with free buccal mucosa or collagen sponge may be useful for ridge augmentation. Compared to no treatment or leaving the wound uncovered, these approaches resulted in more new bone formation and provided adequate horizontal mandibular width.

Inomata K; Marukawa E; Takahashi Y; Omura K

2012-11-01

84

A prospective, randomized controlled preclinical trial to evaluate different formulations of biphasic calcium phosphate in combination with a hydroxyapatite collagen membrane to reconstruct deficient alveolar ridges.  

UK PubMed Central (United Kingdom)

Many patients and clinicians would prefer a synthetic particulate bone replacement graft, but most available alloplastic biomaterials have limited osteogenic potential. An alloplast with increased regenerative capacity would be advantageous for the treatment of localized alveolar ridge defects. This prospective, randomized controlled preclinical trial utilized 6 female foxhounds to analyze the osteogenic impact of different formulations of biphasic calcium phosphate (BCP) in combination with an hydroxyapatite-collagen membrane and their ability to reconstruct deficient alveolar ridges for future implant placement. The grafted sites were allowed to heal 3 months, and then trephine biopsies were obtained to perform light microscopic and histomorphometric analyses. All treated sites healed well with no early membrane exposure or adverse soft tissue responses during the healing period. The grafted sites exhibited greater radiopacity than the surrounding native bone with BCP particles seen as radiopaque granules. The graft particles appeared to be well-integrated and no areas of loose particles were observed. Histologic evaluation demonstrated BCP particles embedded in woven bone with dense connective tissue/marrow space. New bone growth was observed around the graft particles as well as within the structure of the graft particulate. There was intimate contact between the graft particles and newly formed bone, and graft particles were bridged by the newly formed bone in all biopsies from the tested groups. The present study results support the potential of these BCP graft particulates to stimulate new bone formation. Clinical studies are recommended to confirm these preclinical findings.

Nevins M; Nevins ML; Schupbach P; Kim SW; Lin Z; Kim DM

2013-04-01

85

Early bone resorption after vertical bone augmentation--a comparison of calvarial and iliac grafts.  

UK PubMed Central (United Kingdom)

UNLABELLED: OBJECTIVE AND AIM: Severe cases of bone atrophy in the maxilla or mandible are often reconstructed using bone from extraoral donor sides. Most commonly, grafts from the iliac crest are used for augmentation, however, frequently associated with bone resorption as possible late complication. Calvarial bone grafts, often reported to show less resorption, are an alternative. The aim of this study was to compare the bone stability of vertical bone grafts from the iliac crest and the calvarium. PATIENTS AND METHODS: Twenty-three patients receiving vertical onlay bone grafts were included in this retrospective cohort study. In nine patients alveolar ridge defects were treated with bone from the iliac crest. Fourteen patients were reconstructed using calvarial bone grafts. To quantify bone resorption, the data of digital panographs were evaluated. Radiographs were taken prior to bone grafting, after augmentation surgery, 6 months after bone healing, prior to implant surgery, after implant surgery and at yearly intervals thereafter. RESULTS: Postoperative complications at the recipient site occurred equally in both groups. The complication rate was 35.7% for the calvarial group and 33.3% in the iliac crest group. No donor-site complications were reported in either group. After bone augmentation procedure, a mean vertical bone gain of 8.55 mm (SD 5.96) was measured. Bone grafts from the iliac crest showed a significantly higher bone loss of 24.16% (SD 8.47) than grafts from the calvarium (8.44%, SD 3.64) at the time of implant placement (P = 0.0003). Implant survival was similar in both groups. DISCUSSION: Both bone-grafting approaches are successful and reliable techniques, enabling implant placement in even highly atrophied alveolar ridges and with identical implant survival rates, although bone resorption differs. Within the limitations of this study bone from the calvarium shows higher bone stability in the early healing phase.

Mertens C; Decker C; Seeberger R; Hoffmann J; Sander A; Freier K

2013-07-01

86

Dental implants placed on bone subjected to vertical alveolar distraction show the same performance as those placed on primitive bone.  

UK PubMed Central (United Kingdom)

Introduction: Vertical osteogenic alveolar distraction (VOAD) allows for the augmentation of the alveolar ridge for the placement of dental implants in atrophic alveolar ridges. The goal of this paper is to assess long-term peri-implant bone resorption in implants placed on bones subjected to VOAD, comparing it with a group of patients who had implants placed directly on the alveolar bone without previous bone regeneration. Material and Methods: We conducted a follow-up study on 32 patients who were divided into two groups: The Distraction Group (14 patients), and the Distraction-Free Group (18 patients), who received a total of 100 implants. Peri-implant bone loss was measured by means of panoramic X-rays, at the time of loading and one year later, and in 35 implants of each group after 3 years of functional loading. Results: The peri-implant bone resorption (PBR) average observed in the Distraction Group at the time of prosthetic placement is higher (0.50±0.09 mm) than in the Distraction-Free Group (0.25±0.06 mm), showing statistically significant results (p=0.047). PBR levels 1 year after loading were the same for both groups (0.66 mm). At 3 years, they were higher in the Distraction Group (1.03 ± 0.22 mm vs. 0.68 ± 0.08 mm).

Pérez-Sayáns M; León-Camacho MA; Somoza-Martín JM; Fernández-González B; Blanes-Vázquez-Gundín S; Gándara-Rey JM; García-García A

2013-01-01

87

Platelet-rich plasma may prevent titanium-mesh exposure in alveolar ridge augmentation with anorganic bovine bone.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Bone augmentation with the titanium-mesh (Ti-mesh) technique is susceptible to a large rate of complications such as morbidity of bone graft donor site, and mesh exposure to the oral cavity. The purpose of this study was to evaluate the effectiveness of anorganic bovine bone (ABB) in alveolar bone augmentation with the Ti-mesh technique. In addition, we investigated the effect of platelet-rich plasma (PRP) in preventing mesh exposure by using it to cover the Ti-mesh. PATIENTS AND METHODS: Patients included in the clinical trial were randomly allocated by a blinded assistant into two groups. The 30 patients recruited for this study underwent 43 alveolar bone augmentation with the Ti-mesh technique using ABB as graft material in all of them. In 15 patients, the Ti-meshes were covered with PRP (PRP group) whereas in the other 15 the Ti-meshes were not (control group). After 6 months, patients were called for clinical, radiographic, and histological evaluation, and implant placement surgery. A total of 97 implants were placed in the augmented bone and their evolution was followed up for a period of 24 months. RESULTS: Significant differences were found between the two study groups in terms of complications and bone formation. In the control group, 28.5% of the cases suffered from mesh exposure, while in the PRP group, no exposures were registered. Radiographic analysis revealed that bone augmentation was higher in the PRP group than in the control group. Overall, 97.3% of implants placed in the control group and 100% of those placed in the PRP group were successful during the monitoring period. We suggest that the positive effect of PRP on the Ti-mesh technique is due to its capacity to improve soft tissue healing, thereby protecting the mesh and graft material secured beneath the gingival tissues. CONCLUSIONS: Alveolar bone augmentation using ABB alone in the Ti-mesh technique is sufficient for implant rehabilitation. Besides, covering the Ti-meshes with PRP was a determining factor in avoiding mesh exposure. Ti-mesh exposure provoked significant bone loss, but in most cases it did not affect the subsequent placement of implants.

Torres J; Tamimi F; Alkhraisat MH; Manchón A; Linares R; Prados-Frutos JC; Hernández G; López Cabarcos E

2010-10-01

88

Restoration of the maxillary anterior tooth using immediate implantation with simultaneous ridge augmentation  

Directory of Open Access Journals (Sweden)

Full Text Available Atrophy is most severe during the first month of post-extraction in the anterior maxilla with the degree of horizontal bone resorption being nearly twice as high as that of vertical bone resorption. The loss of the buccal alveolar plate following tooth extraction may lead to palatal implant positioning of the implants. Thus, immediate or early implant placement in the extraction socket has been suggested, because it would reduce the time period and the number of surgical intervention and yield higher patient satisfaction compared with delayed placed implants. However, placement of an implant immediately after tooth extraction may result in a gap between the occlusal portion of the implant and the surrounding alveolar bone crest. In this case report, an implant-supported restoration which is in harmony with the surrounding hard and soft tissue was created by the immediate implant placement with ridge augmentation in anterior region with high satisfaction from the patient.

Park Jun-Beom

2010-01-01

89

A case of progressive external root resorption treated with surgical exposure and composite restoration.  

UK PubMed Central (United Kingdom)

Progressive external, root resorption was observed apical to the alveolar crest on the buccal surface of a tooth. The area of root resorption was surgically exposed. To gain access to the root resorption cavity osteoectomy was performed. The soft tissue in the resorption cavity was removed and a composite filling (Retroplast) was placed in the cavity using a dentine bonding system (Gluma). The pulp was removed and the root canal was obturated with gutta-percha points and root canal sealer (AH26). Eight months after treatment no further root resorption was observed. Increased pocket depth and slight bleeding on probing in the area of resorption were evident.

Isidor F; Stokholm R

1992-10-01

90

Orthodontic tooth movement into edentulous ridge areas--a case series.  

UK PubMed Central (United Kingdom)

The aim of this case series was to analyse dimensional alterations of the alveolar ridge and tooth-supporting structures, as well as root resorption, following orthodontic tooth movement into edentulous areas with reduced ridge dimensions. The study involved six subjects (30-70 years) with 10 edentulous jaw areas in the premolar regions. Clinical and radiographic examinations and 3D measurements on scanned study casts were performed at baseline, at retention, and after 1 year of (i) the edentulous area into which the tooth was moved and (ii) the established edentulous area from which the tooth was moved. The orthodontic tooth movement into an edentulous area resulted in most individuals in only minor dimensional alterations of the periodontal tissues. With regard to the width of the alveolar process, the results indicated a decreased width in the newly established edentulous area, whereas in the area into which the tooth had been moved, the width increased. In all cases, the moved tooth showed lateral root resorption on its pressure side at the level of the bone crest at time of retention, but signs of repair were noticed at the 1-year follow-up. Within the limitations of the study, it can be concluded that orthodontic tooth movement results in dimensional alterations of the edentulous ridge and that lateral root resorption is an inevitable side-effect.

Lindskog-Stokland B; Hansen K; Ekestubbe A; Wennström JL

2013-06-01

91

Evaluación clínica y radiográfica de la técnica de distracción osteogénica en la reconstrucción de rebordes alveolares atróficos en la región anterior del maxilar superior A clinical and radiographic evaluation of the distraction osteogenesis technique for the reconstruction of atrophic alveolar ridges in the anterior region of the upper maxilla  

Directory of Open Access Journals (Sweden)

Full Text Available Este estudio tiene como objetivo evaluar clínica y radiográficamente la técnica de distracción osteogénica alveolar en la región anterior del maxilar superior y las posibles complicaciones que pueden aparecer durante el tratamiento. Fueron evaluados 15 pacientes, sometidos a reconstrucción alveolar del maxilar superior en la región anterior con distracción osteogénica, usando un distractor yuxtaóseo. Del total de 15 pacientes encontramos que 13 pacientes (86,6%) obtuvieron un éxito total de la técnica, obteniendo una ganancia ósea real media de 7,04 mm; en 1 paciente (6,66%) fue parcial (2,62 mm) y en 1 paciente (6,66%) se evidenció un fracaso en la técnica, al alcanzar solo 0,76 mm debido a problemas en la activación del distractor. En cuanto a las complicaciones surgidas durante el tratamiento fueron divididas en complicaciones menores, toda aquella que no interfirió en el éxito del tratamiento, y que estuvieron presentes en 8 pacientes (53,33%), y complicaciones mayores aquellas que no permitieron la rehabilitación con implantes, y que fue encontrado solo en 1 paciente (6,66%). La técnica de distracción osteogénica alveolar, demostró ser eficaz en la reconstrucción de rebordes alveolares atróficos con un éxito de 93,33%, presentado pequeñas complicaciones que pueden ser solventadas por medio de un seguimiento por parte del profesional.This study evaluates clinically and radiographically the distraction osteogenesis technique for the reconstruction of atrophic alveolar ridges in the anterior maxilla region, and the possible complications that arise during treatment. Fifteen patients were evaluated, clinically and radiographically, that had been treated with alveolar distraction osteogenesis in the anterior region, using a juxta-osseous distractor. In 13 patients (86.6%) the technique was completely successful, there being an effective bone gain of 7,04 mm. In 1 patient (6.66%) this was partial (2.62 mm) and in 1 patient (6.66%) the technique failed, as there was a gain of just 0,76 mm because of problems during the activation. The complications arising during the alveolar distraction osteogenesis were divided into minor complications that did not compromise the success of the technique, and which were found in 8 patients (53.33%), and major complications that did not permit rehabilitation, which were found in 1 patient (6.66%). The alveolar distraction osteogenesis technique proved to be an effective technique for the reconstruction of atrophic alveolar ridges with a success rate of 93.33%. There were minor complications but the surgeon intervened in time and these were solved.

M.E. Allais de Maurette; P.E. Maurette O’Brien; R. Mazzonetto

2005-01-01

92

Evaluación clínica y radiográfica de la técnica de distracción osteogénica en la reconstrucción de rebordes alveolares atróficos en la región anterior del maxilar superior/ A clinical and radiographic evaluation of the distraction osteogenesis technique for the reconstruction of atrophic alveolar ridges in the anterior region of the upper maxilla  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Este estudio tiene como objetivo evaluar clínica y radiográficamente la técnica de distracción osteogénica alveolar en la región anterior del maxilar superior y las posibles complicaciones que pueden aparecer durante el tratamiento. Fueron evaluados 15 pacientes, sometidos a reconstrucción alveolar del maxilar superior en la región anterior con distracción osteogénica, usando un distractor yuxtaóseo. Del total de 15 pacientes encontramos que 13 pacientes (86,6% (more) ) obtuvieron un éxito total de la técnica, obteniendo una ganancia ósea real media de 7,04 mm; en 1 paciente (6,66%) fue parcial (2,62 mm) y en 1 paciente (6,66%) se evidenció un fracaso en la técnica, al alcanzar solo 0,76 mm debido a problemas en la activación del distractor. En cuanto a las complicaciones surgidas durante el tratamiento fueron divididas en complicaciones menores, toda aquella que no interfirió en el éxito del tratamiento, y que estuvieron presentes en 8 pacientes (53,33%), y complicaciones mayores aquellas que no permitieron la rehabilitación con implantes, y que fue encontrado solo en 1 paciente (6,66%). La técnica de distracción osteogénica alveolar, demostró ser eficaz en la reconstrucción de rebordes alveolares atróficos con un éxito de 93,33%, presentado pequeñas complicaciones que pueden ser solventadas por medio de un seguimiento por parte del profesional. Abstract in english This study evaluates clinically and radiographically the distraction osteogenesis technique for the reconstruction of atrophic alveolar ridges in the anterior maxilla region, and the possible complications that arise during treatment. Fifteen patients were evaluated, clinically and radiographically, that had been treated with alveolar distraction osteogenesis in the anterior region, using a juxta-osseous distractor. In 13 patients (86.6%) the technique was completely succ (more) essful, there being an effective bone gain of 7,04 mm. In 1 patient (6.66%) this was partial (2.62 mm) and in 1 patient (6.66%) the technique failed, as there was a gain of just 0,76 mm because of problems during the activation. The complications arising during the alveolar distraction osteogenesis were divided into minor complications that did not compromise the success of the technique, and which were found in 8 patients (53.33%), and major complications that did not permit rehabilitation, which were found in 1 patient (6.66%). The alveolar distraction osteogenesis technique proved to be an effective technique for the reconstruction of atrophic alveolar ridges with a success rate of 93.33%. There were minor complications but the surgeon intervened in time and these were solved.

Allais de Maurette, M.E.; Maurette O?Brien, P.E.; Mazzonetto, R.

2005-06-01

93

Measurement of ridge alterations following tooth removal: a radiographic study in humans.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The aim of this study was a radiographic mesiodistal analysis of the shape of the bone crest 3 months after tooth removal. MATERIAL AND METHODS: One hundred single tooth extractions were performed on 100 patients because of orthodontic or prosthetic causes. Bite blocks were used for two radiographs: one on the day of extraction and the other after healing of the socket, 3 months later. These X-rays were used to determine: (1) the most apical distance of alveolar ridge resorption, with baseline as the line between bone-to-teeth contact (the greatest distance in bone resorption height) and (2) the mesiodistal distance (MDD) and mesial and distal angles arising after bone tissue modeling. RESULTS: Significant differences (P<0.05) emerged between the MDDs of multiple- [8 mm, 95% confidence interval (CI): 6.09, 9.90] and single-root teeth (5.60 mm, 95% CI: 4.80, 6.50). However, mesial or distal angles or the most apical distance of alveolar ridge resorption did not differ (mean distance in height=4.32 mm, 95% CI: 3.85, 4.78; mean angle=24 degrees ). CONCLUSIONS: In this study, the post-extraction mesiodistal bone distance between teeth adjacent to the edentulous ridge depends on the size of the edentulous space. Nevertheless, the distance does not affect the distance in bone loss height. The distance of bone resorption height reaches a balance at the midpoint, which we consider indicative of stable healing. This resorption process must be considered when placing dental implants in fresh extraction sockets, especially in aesthetic sites, because the implant surfaces could be exposed after 3 months.

Moya-Villaescusa MJ; Sánchez-Pérez A

2010-02-01

94

The remodeling of alveolar bone supporting the mandibular first molar with different levels of periodontal attachment.  

UK PubMed Central (United Kingdom)

The objective of this study was to investigate alveolar bone remodeling of the mandibular first molar with differing levels of periodontal attachment under mastication loading. Three-dimensional finite element models of the mandibular first molar with differing levels of periodontal attachment were established. The stress distributions and bone density changes were analyzed under mastication loading to simulate the remodeling process of mandibular bone based on the theory of strain energy density. The results showed that the alveolar buccal, lingual ridges and root apex areas experienced higher stresses. The stresses and densities of the alveolar bone increased proportionally to increased mastication loading. Decrease in alveolar bone density under extreme loading indicated bone resorption. The remodeling rate was continual with gradual loading. Periodontal ligament support marginally decreased with an increased remodeling rate under extreme loading. Changes in alveolar bone density can reflect the remodeling process of periodontal tissue under mastication loading. The relationship between the change in density and mastication loading during remodeling can provide useful indicators into clinical treatment and diagnosis of the periodontal disease.

Zhao Y; Wang W; Xin H; Zang S; Zhang Z; Wu Y

2013-09-01

95

Adenoma alveolar Alveolar adenoma  

Directory of Open Access Journals (Sweden)

Full Text Available O adenoma alveolar é uma neoplasia benigna rara dos pulmões, com poucos casos descritos na literatura. Freqüentemente, o paciente é assintomático e apresenta-se com um achado acidental em telerradiografias de tórax de um nódulo solitário e bem circunscrito. O diagnóstico definitivo é histológico e o tratamento consiste na ressecção cirúrgica do nódulo.Alveolar adenoma is a rare benign neoplasm of the lungs, and very few cases have been described in the literature. Patients with alveolar adenoma are frequently asymptomatic and are diagnosed through the accidental discovery of a singular, well-delineated nodule on a routine chest X-ray. The definitive diagnosis is made histologically, and the treatment consists of surgical resection of the nodule.

Eduardo Haruo Saito; Luciana Ribeiro de Aaraujo; Leonardo Hoehl Carneiro; Antonio Ambrosio de Oliveira Neto; João Carlos Correa; Luiz Sérgio Carvalho Teixeira

2006-01-01

96

Alveolar distraction osteogenesis – Crestal widening by distraction osteogenesis  

Directory of Open Access Journals (Sweden)

Full Text Available Following tooth extraction, resorption of the residual ridges occurs in both the vertical and the horizontal directions. Most of this resorption occurs within the first 6 months after tooth extraction. To correc tthis vertical/ horizontal/ dual situation, several surgical approaches have been proposed: autogenous bone grafts, guided bone regeneration, and alveolar distraction osteogenesis (ADO). In recent years, ADO has gained an ongoing popularity ,especially in view of its numerous advantages, mostimportant among them being the shortening of treatment periods and earlier dental implant placement. In cases in which there is sufficient vertical height but not enough bucco-ligual width to accommodate an implant, crestal width has to be built. Crestal widening by distraction osteogenesis is the preferred technique in suchcases. In this study a new type of crest widener, the"Laster" Crest Widening Distractor, is presented, reporting two cases where crest widening by distraction was chosen as the preferred treatment plan. Finally the main advantages and disadvantages of the new crest widening distractor are discussed, helping thus the clinician to make up his mind about this new promising device and surgical technique.

Zvi Laster

2010-01-01

97

Aggressive condylar resorption.  

UK PubMed Central (United Kingdom)

This article describes the clinical and radiographic findings in a patient with unilateral aggressive condylar resorption that was diagnosed as osteoarthritis. We present a comprehensive documentation of the clinical manifestations, the appearance on conventional and advanced imaging, and the histopathologic findings. We discuss the systematic approach to develop a differential diagnosis, with specific emphasis on osteoarthritis and idiopathic condylar resorption. Finally, we also discuss the factors that play a role in management of this condition.

Sansare K; Raghav M; Mallya S; Mundada N; Karjodkar F; Randive P; Meshram D; Shirsat P

2013-01-01

98

Influence of presence or absence of keratinized mucosa on the alveolar bony crest level as it relates to different buccal marginal bone thicknesses. An experimental study in dogs.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To investigate the influence of the presence or absence of keratinized mucosa on the alveolar bony crest level as it relates to different buccal marginal bone thicknesses. MATERIAL AND METHODS: In six beagle dogs, the mandibular premolars and first molars were extracted bilaterally. In the right side of the mandible (test), flaps were elevated, and the buccal as well as part of the lingual masticatory mucosa was removed. The flap was released coronally to allow a primary wound closure. In the left side, the wounds were left unsutured with the keratinized mucosa remaining (control). After 3 months of healing, a complete absence of keratinized mucosa was found at the test sites. Two recipient sites were prepared at each side of the mandible, one in the premolar and one in the molar region. A buccal bony ridge width of approximately 1 and 2 mm was obtained at the premolar and molar region, respectively. Implants were installed with the shoulder flush with the buccal alveolar bony crest, and abutments were connected to allow a nonsubmerged healing. At least 2 mm of keratinized mucosa was surrounding the control sites, while at the test sites, the implants were bordered by alveolar mucosa. After 3 months, the animals were euthanized and ground sections obtained. RESULTS: A higher vertical bony crest resorption was observed at the test compared with the control sites both at the premolar and molar regions, the differences being statistically significant. The top of the peri-implant mucosa was located more coronally at the control compared with the test sites. The horizontal resorption measured 1 mm below the implant shoulder was similar at the test and control sites. Only limited differences were found between premolar and molar sites, with the exclusion of the horizontal resorption that was higher at the test compared with the control sites. CONCLUSIONS: A higher alveolar buccal bony crest resorption and a more apical soft tissue marginal position should be expected, when implants are surrounded with thin alveolar mucosa at the time of installation, independently of the thickness of the buccal bony crest.

Bengazi F; Botticelli D; Favero V; Perini A; Urbizo Velez J; Lang NP

2013-07-01

99

A method for measuring post-extraction alveolar dimensional changes with volumetric computed tomography.  

UK PubMed Central (United Kingdom)

The aim of this study is to present a predictable method for evaluating dimensional changes in the alveolar ridge through cone beam computed tomography (CT). Twenty subjects with single-rooted tooth extraction indication were selected for this preliminary report, which is part of a larger ongoing investigation. After extraction, two CT scans were performed; the first within 24 hours post-extraction (TC1) and the second 6 months (TC2) later. A radiographic guide with a radiopaque element placed along the tooth axis was developed to locate the same plane of reference in two different CT scans. For each patient, backtrack analysis was performed in order to establish the reproducibility error of a predetermined point in space between two CT scans. Briefly, an anatomical landmark was selected and its coordinates to the radiopaque marker were recorded. One week later, the coordinates were followed backwards in the same CT scan to obtain the position where the reference point should be located. A similar process was carried out between two different CT scans taken 6 months apart. The distance between the anatomical reference and the obtained point of position was calculated to establish the accuracy of the method. Additionally, a novel method for evaluating dimensional changes of the alveolus after tooth extraction is presented. The backtrack analysis determined an average within-examiner discrepancy between both measurements from the same CT scan of 0.19 mm. SD +/- 0.05. With the method presented herein, a reference point in a CT scan can be accurately backtracked and located in a second CT scan taken six months later. Taken together they open the possibility of calculating dimensional changes that occur in the alveolar ridge over time, such as post-extraction alveolar resorption, or the bone volume gained after different augmentation procedures.

Bontá H; Galli FG; Caride F; Carranza N

2012-01-01

100

A method for measuring post-extraction alveolar dimensional changes with volumetric computed tomography.  

Science.gov (United States)

The aim of this study is to present a predictable method for evaluating dimensional changes in the alveolar ridge through cone beam computed tomography (CT). Twenty subjects with single-rooted tooth extraction indication were selected for this preliminary report, which is part of a larger ongoing investigation. After extraction, two CT scans were performed; the first within 24 hours post-extraction (TC1) and the second 6 months (TC2) later. A radiographic guide with a radiopaque element placed along the tooth axis was developed to locate the same plane of reference in two different CT scans. For each patient, backtrack analysis was performed in order to establish the reproducibility error of a predetermined point in space between two CT scans. Briefly, an anatomical landmark was selected and its coordinates to the radiopaque marker were recorded. One week later, the coordinates were followed backwards in the same CT scan to obtain the position where the reference point should be located. A similar process was carried out between two different CT scans taken 6 months apart. The distance between the anatomical reference and the obtained point of position was calculated to establish the accuracy of the method. Additionally, a novel method for evaluating dimensional changes of the alveolus after tooth extraction is presented. The backtrack analysis determined an average within-examiner discrepancy between both measurements from the same CT scan of 0.19 mm. SD +/- 0.05. With the method presented herein, a reference point in a CT scan can be accurately backtracked and located in a second CT scan taken six months later. Taken together they open the possibility of calculating dimensional changes that occur in the alveolar ridge over time, such as post-extraction alveolar resorption, or the bone volume gained after different augmentation procedures. PMID:23230640

Bontá, Hernán; Galli, Federico G; Caride, Facundo; Carranza, Nelson

2012-01-01

 
 
 
 
101

[Alveolar hemorrhage].  

UK PubMed Central (United Kingdom)

Diffuse alveolar hemorrhage (DAH) is defined by the presence of red blood cells originating from the lung capillaries or venules within the alveoli. The diagnosis is established on clinical features, radiological pattern, and especially bronchoalveolar lavage. Diffuse alveolar hemorrhage may have many immune or non-immune causes. Immune causes of DAH include vasculitides, connective tissue diseases, especially systemic lupus erythematosus, and antiglomerular basement membrane antibody disease (Goodpasture's syndrome). Treatment is both supportive and causal, often based on high dose corticosteroids and immunosuppressive therapy (especially intravenous cyclophosphamide). Plasma exchanges are performed in antiglomerular basement membrane antibody disease and systemic lupus erythematosus, and are considered in systemic vasculitis. Non-immune causes of DAH mainly include heart diseases, coagulation disorders, infections, drug toxicities and idiopathic DAH. Treatment of non-immune DAH is that of its cause. Whatever the cause, DAH is an emergency requiring prompt assessment and early treatment.

Traclet J; Lazor R; Cordier JF; Cottin V

2013-04-01

102

Pulmonary alveolar proteinosis  

Science.gov (United States)

Alveolar proteinosis; Pulmonary alveolar phospholipoproteinosis ... In some cases, the cause of pulmonary alveolar proteinosis is unknown. In others, it occurs with lung infection or an immune problem. It also can occur with cancers of ...

103

Low-dose doxycycline prevents inflammatory bone resorption in rats  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Matrix metalloproteinases (MMP) are considered to be key initiators of collagen degradation, thus contributing to bone resorption in inflammatory diseases. We determined whether subantimicrobial doses of doxycycline (DX) ((more) 7 days. Alveolar bone loss (ABL) was measured macroscopically in one hemiarcade and the contralateral hemiarcade was processed for histopathologic analysis. Groups of six animals each were treated with DX (2.5, 5 or 10 mg kg-1 day-1, sc, 7 days) and compared to nontreated (NT) rats. NT rats displayed significant ABL, severe mononuclear cell influx and increase in osteoclast numbers, which were significantly reduced by 5 or 10 mg kg-1 day-1 DX. These data show that DX inhibits inflammatory bone resorption in a manner that is independent of its antimicrobial properties.

Bezerra, M.M.; Brito, G.A.C.; Ribeiro, R.A.; Rocha, F.A.C.

2002-05-01

104

Influence of anatomical barriers on maxillary incisor root resorption after orthodontic treatment with premolar extractions  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUCTION: Apical root resorption is a frequent and occasionally critical problem in orthodontic patients undergoing induced tooth movement. One of the factors that might influence prognosis, especially in maxillary incisors, which most frequently present resorptions, are the so-called the anatomical barriers; that is, proximity of the buccal and palatal cortical bones to the maxillary incisor roots. OBJECTIVE: The purpose of this research was to investigate whether patients with excessive vertical growth really present a small distance between the alveolar cortical bones and the maxillary incisor roots, and whether there is a correlation between this distance and the root resorption index in comparison with patients presenting horizontal growth. METHODS: The sample comprised orthodontic records of 18 patients with extraction planning of first maxillary premolars and treatment by the standard and/or preadjusted edgewise brackets. Their initial and final periapical radiographs were evaluated to determine the amount of root resorption that occurred. RESULTS: On the palatal side, patients with excessive vertical growth (Group 2 - SN-GoGn > 43º) showed a narrower alveolar bone than the horizontal growth patients (Group 1 - SN-GoGn < 29º). However, the distance between the buccal cortical bone and the central incisor root apex showed no significant difference between Groups 1 and 2; CONCLUSIONS: It was concluded that there are no correlations between the proximity of buccal cortical bone, maxillary incisor roots and the root resorption index.

Antonio Geraldo de Oliveira; Fabiana Guilhermina Ferreira Castro

2012-01-01

105

Low-dose doxycycline prevents inflammatory bone resorption in rats  

Directory of Open Access Journals (Sweden)

Full Text Available Matrix metalloproteinases (MMP) are considered to be key initiators of collagen degradation, thus contributing to bone resorption in inflammatory diseases. We determined whether subantimicrobial doses of doxycycline (DX) (<=10 mg kg-1 day-1), a known MMP inhibitor, could inhibit bone resorption in an experimental periodontitis model. Thirty male Wistar rats (180-200 g) were subjected to placement of a nylon thread ligature around the maxillary molars and sacrificed after 7 days. Alveolar bone loss (ABL) was measured macroscopically in one hemiarcade and the contralateral hemiarcade was processed for histopathologic analysis. Groups of six animals each were treated with DX (2.5, 5 or 10 mg kg-1 day-1, sc, 7 days) and compared to nontreated (NT) rats. NT rats displayed significant ABL, severe mononuclear cell influx and increase in osteoclast numbers, which were significantly reduced by 5 or 10 mg kg-1 day-1 DX. These data show that DX inhibits inflammatory bone resorption in a manner that is independent of its antimicrobial properties.

Bezerra M.M.; Brito G.A.C.; Ribeiro R.A.; Rocha F.A.C.

2002-01-01

106

Ridge 2000  

Science.gov (United States)

... INFORMATION Program Title: RIDGE 2000 Synopsis of Program: RIDGE 2000 is a community-based science ... the Earth-encircling mid-ocean ridge system. Central to the RIDGE 2000 science plan is the ...

107

Periosteum: Resorption or Formation Area?  

Directory of Open Access Journals (Sweden)

Full Text Available Periosteum is a membrane that lines the outer surface of all bones, except at the joints of long bones. Endosteum lines the inner surface of all bones. Periosteal formation is observed in every stage of life, especially in childhood and early adulthood. Formation continues mechanically as a response to load. Periosteal resorption is observed especially in the flat bones in the growing period. In adulthood, resorption is a part of remodeling. The periosteal surface contains fewer osteoclasts than does the endosteal surface, and remodeling on the periosteal surface is much slower. For this reason, adult periosteum is defined as a formation area. Turk Jem 2008; 12: 28-31

Betül U?ur Altun

2008-01-01

108

Resorption pattern and radiographic diagnosis of invasive cervical resorption  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Summary The aim of this study was to evaluate, whether and how the histologic structure of invasive cervical resorption (external granulomas) affect their clinical radiographic diagnosis. For this purpose, nine more or less intact extracted teeth, of which intraoral radiographs were available, were ...

Luso, Sandra; Luder, Hans Ulrich

109

Root resorption during orthodontic treatment.  

UK PubMed Central (United Kingdom)

DATA SOURCES: Medline, Embase, LILACS, The Cochrane Library (Cochrane Database of Systematic Reviews, CENTRAL, and Cochrane Oral Health Group Trials Register) Web of Science, EBM Reviews, Computer Retrieval of Information on Scientific Project (CRISP, www.crisp.cit.nih.gov), On-Line Computer Library Center (www.oclc.org), Google Index to Scientific and Technical Proceedings, PAHO (www.paho.org), WHOLis (www.who.int/library/databases/en), BBO (Brazilian Bibliography of Dentistry), CEPS (Chinese Electronic Periodical Services), Conference materials (www.bl.uk/services/bsds/dsc/conference.html), ProQuest Dissertation Abstracts and Thesis database, TrialCentral (www.trialscentral.org), National Research Register (www.controlled-trials.com), www.Clinicaltrials.gov and SIGLE (System for Information on Grey Literature in Europe). STUDY SELECTION: Randomised controlled trials including split mouth design, recording the presence or absence of external apical root resorption (EARR) by treatment group at the end of the treatment period. DATA EXTRACTION AND SYNTHESIS: Data were extracted independently by two reviewers using specially designed and piloted forms. Quality was also assessed independently by the same reviewers. RESULTS: After evaluating titles and abstracts, 144 full articles were obtained of which 13 articles, describing 11 trials, fulfilled the criteria for inclusion. Differences in the methodological approaches and reporting results made quantitative statistical comparisons impossible. Evidence suggests that comprehensive orthodontic treatment causes increased incidence and severity of root resorption, and heavy forces might be particularly harmful. Orthodontically induced inflammatory root resorption is unaffected by archwire sequencing, bracket prescription, and self-ligation. Previous trauma and tooth morphology are unlikely causative factors. There is some evidence that a two- to three-month pause in treatment decreases total root resorption. CONCLUSIONS: The results were inconclusive in the clinical management of root resorption, but there is evidence to support the use of light forces, especially with incisor intrusion.

Walker S

2010-01-01

110

Analysis of the prevalence of different topographical characteristics of the residual ridge in mandibular free-end arches Análise da prevalência de diferentes características topográficas do rebordo residual em arcos mandibulares com extremidades livres  

Directory of Open Access Journals (Sweden)

Full Text Available This study observed the prevalence of different types of residual ridge inclination in free-ends of mandibles and reported possible correlative factors that may affect resorption. For this purpose, periapical radiographs and individual data collected from a sample of 64 hemiarches were used. Two radiographs were taken of each free-end, and tracing was employed to determine the angles formed by the resorption configuration in the area of the 1st mandibular molar. The following conclusions were drawn: 1) the great majority of alveolar ridges were distally descending; 2) the average angle was wider for users of mandibular removable partial dentures; 3) the results obtained suggest that the type of opposing maxillary arch affects the inclination of mandibular ridges; 4) greater inclination was observed when the 2nd bicuspids of the mandible were the abutment teeth; 5) no significant correlation was established between age, sex and residual ridge resorption.Esta pesquisa constatou a prevalência dos tipos de rebordos residuais no sentido ântero-posterior em extremidades livres inferiores, além de correlacionar alguns fatores que possam influenciar as suas reabsorções. Para isso, utilizamos radiografias periapicais e dados individuais colhidos na amostra de 64 hemiarcos; foram obtidas 2 radiografias de cada área de extremidade livre e, a partir de traçados, determinamos os ângulos formados pela reabsorção na altura do 1º molar inferior. Podemos constatar que: 1º) a grande maioria de inclinação encontrada foi de rebordos descendentes para distal; 2º) a média de angulação foi maior para usuários de prótese parcial removível inferior; 3º) os resultados sugeriram existir influência do tipo de arco antagônico superior na inclinação dos rebordos inferiores; 4º) observou-se aumento de inclinação quando os segundos pré-molares inferiores eram os dentes adjacentes ao espaço protético; e 5º) não foram encontradas correlações significantes entre idade, sexo e reabsorção do rebordo residual.

Carlos Gramani Guedes; Artêmio Luiz Zanetti; Pedro Paulo Feltrin

2004-01-01

111

Influence of anatomical barriers on maxillary incisor root resorption after orthodontic treatment with premolar extractions  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english INTRODUCTION: Apical root resorption is a frequent and occasionally critical problem in orthodontic patients undergoing induced tooth movement. One of the factors that might influence prognosis, especially in maxillary incisors, which most frequently present resorptions, are the so-called the anatomical barriers; that is, proximity of the buccal and palatal cortical bones to the maxillary incisor roots. OBJECTIVE: The purpose of this research was to investigate whether pa (more) tients with excessive vertical growth really present a small distance between the alveolar cortical bones and the maxillary incisor roots, and whether there is a correlation between this distance and the root resorption index in comparison with patients presenting horizontal growth. METHODS: The sample comprised orthodontic records of 18 patients with extraction planning of first maxillary premolars and treatment by the standard and/or preadjusted edgewise brackets. Their initial and final periapical radiographs were evaluated to determine the amount of root resorption that occurred. RESULTS: On the palatal side, patients with excessive vertical growth (Group 2 - SN-GoGn > 43º) showed a narrower alveolar bone than the horizontal growth patients (Group 1 - SN-GoGn

Oliveira, Antonio Geraldo de; Castro, Fabiana Guilhermina Ferreira

2012-04-01

112

Contaminant resorption during soil washing  

International Nuclear Information System (INIS)

To evaluate the applicability of soil washing to a specific site requires some basic research in how contaminants are bound. Much can be learned from sequential extraction methodology based on micronutrient bioavailability studies wherein the soil matrix is chemically dissected to selectively remove particular fixation mechanisms independently. This procedure uses a series of progressively more aggressive solvents to dissolve the principle phases that make up a soil, however, the published studies do not appear to consider the potential for a contaminant released from one type of site to resorb on another site during an extraction. This physical model assumes no ion exchange or adsorption at sites either previously occupied by other ions, or exposed by the dissolution. Therefore, to make engineering use of the sequential extraction data, the release of contamination must be evaluated relative to the effects of resorption. Time release studies were conducted to determine the optimum duration for extraction to maximize complete destruction of the target matrix fraction while minimizing contaminant resorption. Tests with and without a potassium brine present to inhibit cesium resorption indicated extraction efficiency could be enhanced by as much as a factor of ten using the brine

1993-01-01

113

Hollow dentures: treatment option for atrophic ridges. a clinical report.  

UK PubMed Central (United Kingdom)

Severely atrophic ridges provide decreased retention, support, and stability and pose a clinical challenge to the success of complete denture prostheses. Extreme ridge resorption also increases the interridge distance. Restoration of the vertical dimension and esthetics thus demands increased height of the prosthesis and in turn leads to an increase in prosthesis weight. Reducing the weight of the denture enhances stability and retention and reduces further resorption of the jaw, thereby favoring the prognosis of the denture. This report describes the rehabilitation of an edentulous patient with resorbed maxillary and mandibular ridges and an increased interridge distance using simplified techniques of fabricating hollow dentures.

Caculo SP; Aras MA; Chitre V

2013-04-01

114

The edentulous ridge expansion (ERE) technique an experimental study in the dog.  

UK PubMed Central (United Kingdom)

OBJECTIVE: To compare the healing and bony crest resorption at implants installed conventionally or applying an edentulous ridge expansion (ERE) technique in the maxilla. MATERIAL AND METHODS: In six Labrador dogs, the first and second maxillary incisors were extracted bilaterally. In the left side of the maxilla (Test), the flaps were elevated and the buccal plate of the alveoli and septa was removed. After 3 months of healing, partial-thickness (split) flaps were dissected and the residual alveolar bone was exposed. In the right side of the maxilla, an implant was installed conventionally (Type IV; Control) while, in the left side, the ERE technique was adopted. Hence, an expansion of the buccal bony crest was obtained, and the implant was subsequently installed (Test). After 3 months of healing, biopsies were obtained and ground sections were prepared for histological analyses. RESULTS: A buccal vertical resorption of the bony crest of 2.2 ± 1.2 mm and 1.6 ± 0.7 mm was found at the test and control sites, respectively. The difference, however, did not reach statistical significance. The coronal level of osseointegration at the buccal aspect was located at 3.1 ± 1.0 mm and 2.2 ± 0.7 mm from the implant shoulder at the test and control sites, respectively, the difference being statistically significant. The mean values of the mineralized bone-to-implant contact (MBIC%) ranged from 43% to 48% at the buccal and lingual sites. No differences reached statistical significance. CONCLUSIONS: Implants installed by applying an ERE technique may osseointegrate similarly to conventional implant installation. However, vertical and horizontal resorption of the displaced buccal bony wall occurred as well.

Beolchini M; Lang NP; Viganò P; Bengazi F; Triana BG; Botticelli D

2013-09-01

115

The influence of bone mineral density and body mass index on resorption of edentulous jaws.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The aim of this study is to determine the relation of osteoporosis and body mass index to edentulous jaw bone resorption. MATERIAL AND METHODS: Study included 48 postmenopausal totally edentulous female patients, aged 50 to 84 years (average age 69.73), with period of at least 2 years after last tooth extraction. Bone mineral density was determined in the femoral neck and the lumbar area L2-L4 by dual energy x-ray absorptiometry (DEXA) using Lunar DEXA DPX-NT, GE Medical Systems hardware. Body mass index was calculated (BMI (kg/m(2))) using data from DEXA results. Lateral cephalogram (Pantomograph Trophycan C), and radiological measurement in the symphysis of the mandible was performed for each patient. Degree of the edentulous residual ridge resorption was determined clinically on diagnostic casts of anatomic impressions by classification of Kalk. RESULTS: There is no statistically significant difference between groups, comparing mandibular bone height changes (p=0.054) and various degrees of residual ridge resorption in maxilla (p=0.743) and mandible (p=0.752) with different bone mineral contents. There is a statistically significant correlation between radiological mandibular measurement and body mass index (p=0.004). Statistically significant difference is also observed between various degrees of residual ridge resorption in maxilla (p=0.049) and mandible (p=0.027) and body mass index. CONCLUSIONS: Resorption of edentulous jaw bone does not increase when bone mineral density decreases. More severe manifestation of edentulous jaw bone resorption is observed in patients with diminished body mass index.

Ozola B; Slaidina A; Laurina L; Soboleva U; Lejnieks A

2011-01-01

116

Biphasic alloplastic graft used to preserve the dimension of the edentulous ridge: an experimental study in the dog.  

UK PubMed Central (United Kingdom)

BACKGROUND: Loss of teeth results in marked qualitative and quantitative alterations of the alveolar process at the edentulous site. It was observed that a graft comprised of bovine bone mineral placed in the fresh extraction socket delayed tissue modeling, but preserved the dimension of the ridge at edentulous sites. OBJECTIVE: To analyze the influence of a biphasic synthetic graft on tissue modeling and remodeling during healing of extraction wounds. MATERIAL AND METHODS: Five beagle dogs were used. Two premolars in the maxilla and two in the mandible were included. Full thickness flaps were elevated and the distal roots were removed. An alloplastic graft (BPCAP; ?-TCP core coated with nanocrystalline biomimetic hydroxyapatite) embedded in porcine collagen was placed to fill the fresh extraction socket of the premolar sites. Flaps were replaced to cover the entrance of the extraction sockets during early healing. The extraction and grafting procedures were scheduled to allow for the study of 1, 2, and 3 months socket healing. The biopsies from the maxillary sites were decalcified, embedded in paraffin, and stained to allow the study of various aspects of hard tissue formation. The biopsies from the mandibular sites were processed for ground sectioning and used to evaluate alterations of ridge dimensions after 3 months of socket healing. RESULTS AND CONCLUSION: It was documented that the biphasic alloplastic graft did not undergo marked resorption during tissue modeling and remodeling, but allowed large amounts of bone to form within the post-extraction site. Grafting the experimental sites with this biomaterial furthermore counteracted ridge resorption that otherwise occurs following tooth extraction.

Lindhe J; Araújo MG; Bufler M; Liljenberg B

2013-10-01

117

The four mechanisms of dental resorption initiation.  

UK PubMed Central (United Kingdom)

The aim of this study is to present a classification with a clinical application for root resorption, so that diagnosis will be more objective and immediately linked to the source of the problem, leading the clinician to automatically develop the likely treatment plan with a precise prognosis. With this purpose, we suggest putting together all diagnosed dental resorptions into one of these four criteria: 1) Root resorption caused by cementoblast cell death, with preservation of the Malassez epithelial rests. 2) Root resorption by cementoblasts and Malassez epithelial rests death. 3) Dental resorption by odontoblasts cell death with preservation of pulp vitality. 4) Dental resorption by direct exposure of dentin to gingival connective tissue at the cementoenamel junction gaps.

Consolaro A

2013-05-01

118

Microcracks and osteoclast resorption activity in vitro.  

Science.gov (United States)

During bone remodeling osteoclasts resorb bone, thus removing material, e.g., damaged by microcracks, which arises as a result of physiological loading and could reduce bone strength. Such a process needs targeted bone resorption exactly at damaged sites. Osteocytic signaling plays a key role in this process, but it is not excluded that osteoclasts per se may possess toposensitivity to recognize and resorb damaged bone since it has been shown that resorption spaces are associated with microcracks. To address this question, we used an in vitro setup of a pure osteoclast culture and mineralized substrates with artificially introduced microcracks and microscratches. Histomorphometric analyses and statistical evaluation clearly showed that these defects had no effect on osteoclast resorption behavior. Osteoclasts did not resorb along microcracks, even when resorption started right beside these damages. Furthermore, quantification of resorption on three different mineralized substrates, cortical bone, bleached bone (bone after partial removal of the organic matrix), and dentin, revealed lowest resorption on bone, significantly higher resorption on bleached bone, and highest resorption on dentin. The difference between native and bleached bone may be interpreted as an inhibitory impact of the organic matrix. However, the collagen-based matrix could not be the responsible part as resorption was highest on dentin, which contains collagen. It seems that osteocytic proteins, stored in bone but not present in dentin, affect osteoclastic action. This demonstrates that osteoclasts per se do not possess a toposensitivity to remove microcracks but may be influenced by components of the organic bone matrix. PMID:22271249

Rumpler, Monika; Würger, Tanja; Roschger, Paul; Zwettler, Elisabeth; Peterlik, Herwig; Fratzl, Peter; Klaushofer, Klaus

2012-01-24

119

Microcracks and osteoclast resorption activity in vitro.  

UK PubMed Central (United Kingdom)

During bone remodeling osteoclasts resorb bone, thus removing material, e.g., damaged by microcracks, which arises as a result of physiological loading and could reduce bone strength. Such a process needs targeted bone resorption exactly at damaged sites. Osteocytic signaling plays a key role in this process, but it is not excluded that osteoclasts per se may possess toposensitivity to recognize and resorb damaged bone since it has been shown that resorption spaces are associated with microcracks. To address this question, we used an in vitro setup of a pure osteoclast culture and mineralized substrates with artificially introduced microcracks and microscratches. Histomorphometric analyses and statistical evaluation clearly showed that these defects had no effect on osteoclast resorption behavior. Osteoclasts did not resorb along microcracks, even when resorption started right beside these damages. Furthermore, quantification of resorption on three different mineralized substrates, cortical bone, bleached bone (bone after partial removal of the organic matrix), and dentin, revealed lowest resorption on bone, significantly higher resorption on bleached bone, and highest resorption on dentin. The difference between native and bleached bone may be interpreted as an inhibitory impact of the organic matrix. However, the collagen-based matrix could not be the responsible part as resorption was highest on dentin, which contains collagen. It seems that osteocytic proteins, stored in bone but not present in dentin, affect osteoclastic action. This demonstrates that osteoclasts per se do not possess a toposensitivity to remove microcracks but may be influenced by components of the organic bone matrix.

Rumpler M; Würger T; Roschger P; Zwettler E; Peterlik H; Fratzl P; Klaushofer K

2012-03-01

120

Horizontal augmentation through the ridge-split procedure: a predictable surgical modality in implant reconstruction.  

UK PubMed Central (United Kingdom)

Among alveolar ridge augmentation techniques, the ridge-split procedure demonstrates many benefits, including no need for a second (donor) surgical site, rare risk of inferior alveolar nerve injury, and less pain and swelling, and others. Lateral bone augmentation through the ridge-split works best in a localized lateral bony defect intended for 1 or 2 implants and where the ridge is vertically intact. In this article, the authors present a detailed description of the implant-driven technique of alveolar ridge-split procedure in small and large bone deficiencies, in maxilla and mandible, supplemented by multiple photographs. The authors emphasize the need for careful manipulation of the thin ridge based on knowledge of precise surgical principles and stress that a practitioner needs specialized training and experience to perform this type of alveolar bone augmentation.

Tolstunov L; Hicke B

2013-02-01

 
 
 
 
121

Tertiary bone grafting with or without premaxilla osteotomy in adult alveolar clefts—Techniques and early outcome  

Directory of Open Access Journals (Sweden)

Full Text Available The outcome of alveolar bone grafting in adult patients is sparsely reported. Here, we present a description of the surgical techniques used in a Nigerian teaching hospital and a preliminary report of the first five cases of adult alveolar cleft bone grafting accomplished with or without repositioning the premaxilla. Although, evidence of bone resorption was observed within 6 months after the operation, satisfactory bone level and aesthetic outcome was recorded in all cases. We concluded that tertiary alveolar bone grafting is desirable for all cases where alveolar clefts have persisted into adulthood to enhance the psyche of the cleft patients and to motivate them for further rehabilitation. Prompt placement of dental implant into the grafted area is recommended to mitigate subsequent resorption of the bone graft.

Oladimeji A. Akadiri; Babatunde O. Akinbami; Benjamin M. Kejeh

2012-01-01

122

Proteinosis alveolar pulmonar Pulmonary alveolar proteinosis  

Directory of Open Access Journals (Sweden)

Full Text Available La proteinosis alveolar pulmonar es una enfermedad respiratoria crónica, caracterizada por alteración en el metabolismo del surfactante, lo que determina su acumulación anormal en el espacio alveolar. Es una enfermedad extremadamente rara. Se han reportado solamente 500 casos en la literatura. Se describió por primera vez en 1958. Se presenta un caso de proteinosis alveolar pulmonar en un lactante de 2 meses, con desnutrición proteico energética, que ingresa por dificultad respiratoria e hipoxemia, y, con imágenes radiológicas de tipo retículo-nodulillar, en vidrio deslustrado, en el cual se plantea inicialmente el diagnóstico de bronconeumonía. Ante la evolución desfavorable y no respuesta al tratamiento, se realizó un estudio para descartar enfermedades pulmonares crónicas. El paciente fallece y se confirma el diagnóstico por anatomía patológica. Se realiza una revisión del tema.The pulmonary alveolar proteinosis is a chronic respiratory disease characterized by surfactant metabolism alteration determining its abnormal accumulation in the alveolar space. It is a disease very rare and in literature only 500 cases have been reported; it was described for the first time in 1958. This is a case presentation of pulmonary alveolar proteinosis in an infant aged 2 months with energetic protein malnutrition admitted due to respiratory difficulty and hypoxemia and with radiologic images of the reticulonodulillary, in frosting glass, where initially is made the diagnosis of bronchopneumonia. In the face of unfavorable evolution and no response to treatment, a study was conducted to rule out chronic pulmonary diseases. Patient died confirming the diagnosis according to the pathologic anatomy. A review on subject is carried out.

Concepción Sánchez Infante; Anixia Serrano Sánchez; Roberto Razón Behar; Cristina Reyes López

2011-01-01

123

Orthodontic root resorption studied by electron microscopy.  

Science.gov (United States)

The present study supports previous findings that root resorption takes place simultaneously with and after the elimination of hyalinized tissue. The cementoid layer and the more mature periodontal collagen fibers adjacent to cementum are possible barriers preventing root resorption. The microenvironment around hyalinized tissue is favorable for the introduction of hard-tissue resorbing cells. The findings show that the elimination of hyalinized tissue leads to the removal of the cementoid and the mature collagen thus leaving a raw cemental surface without a barrier. It is therefore hypothesized that such an area is readily attacked by odontoclasts. Once resorption lacunae are established, the cementum is resorbed from the rear as an undermining process. By continued orthodontic force application the resorption process will proceed even after all hyalinized tissue is eliminated. If the orthodontic force is discontinued or falls under a certain level, the resorption lacunae are repaired. PMID:65136

Rygh, P

1977-01-01

124

Orthodontic root resorption studied by electron microscopy.  

UK PubMed Central (United Kingdom)

The present study supports previous findings that root resorption takes place simultaneously with and after the elimination of hyalinized tissue. The cementoid layer and the more mature periodontal collagen fibers adjacent to cementum are possible barriers preventing root resorption. The microenvironment around hyalinized tissue is favorable for the introduction of hard-tissue resorbing cells. The findings show that the elimination of hyalinized tissue leads to the removal of the cementoid and the mature collagen thus leaving a raw cemental surface without a barrier. It is therefore hypothesized that such an area is readily attacked by odontoclasts. Once resorption lacunae are established, the cementum is resorbed from the rear as an undermining process. By continued orthodontic force application the resorption process will proceed even after all hyalinized tissue is eliminated. If the orthodontic force is discontinued or falls under a certain level, the resorption lacunae are repaired.

Rygh P

1977-01-01

125

Measuring mandibular ridge reduction  

International Nuclear Information System (INIS)

[en] This thesis investigates the mandibular reduction in height of complete denture wearers and overdenture wearers. To follow this reduction in the anterior region as well as in the lateral sections of the mandible, an accurate and reproducible measuring method is a prerequisite. A radiologic technique offers the best chance. A survey is given of the literature concerning the resorption process after the extraction of teeth. An oblique cephalometric radiographic technique is introduced as a promising method to measure mandibular ridge reduction. The reproducibility and the accuracy of the technique are determined. The reproducibility in the positioning of the mandible is improved by the introduction of a mandibular support which permits a precise repositioning of the edentulous jaw, even after long periods of investigation. (Auth.)

1984-01-01

126

Microlitiasis alveolar pulmonar Pulmonary alveolar microlithiasis  

Directory of Open Access Journals (Sweden)

Full Text Available La microlitiasis alveolar pulmonar (MAP) es una enfermedad rara caracterizada por la presencia difusa y bilateral de microlitos de fosfato de calcio en el interior de los espacios alveolares. La progresión de esta enfermedad potencialmente letal, es lenta y la mayoría de los pacientes permanecen asintomáticos por años o décadas, resultando en deterioro lento de sus funciones pulmonares. El hallazgo de la radiografía de tórax en "tormenta de arena" es característico de la entidad. Recientemente se identificaron mutaciones en el gen SLC34A2, que codifica para el cotransportador tipo IIb de fosfato sódico, como responsable de la enfermedad. De los casi 600 casos, sólo seis han sido reportados en Colombia. Nosotros presentamos un caso de microlitiasis alveolar pulmonar en un hombre de 27 años, con dificultad respiratoria progresiva, cuyo diagnóstico se hizo por los hallazgos radiográficos y se confirmó por biopsia transbronquial. En el seguimiento durante dos años, evolucionó hacia el deterioro de su función respiratoria y es candidato a trasplante de pulmón.Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by the diffuse and bilateral presence of calcium phosphate microlite in the alveolar spaces. The progression of this potentially lethal disease is show and most of the patients remain asymptomatic during years or decades, resulting in a show deterioration of the pulmonary function. The typical finding of the "sand storm" in the chest X-ray is characteristic of this entity. Mutations in the SLC34A2 gene that does the coding for the type II co-transporter of sodium phosphate were identified as responsible for this disease. Of the almost 600 cases, only 6 have been reported in Colombia. We are presenting a case of pulmonary alveolar microlite in a 27 year old man, with progressive respiratory distress whose diagnosis was made by the X-ray findings and confirmed by trans bronchial biopsy. In the 2 years follow-up, shows evolution towards deterioration of his respiratory function making him a candidate for lung transplantation.

Franco Javier Vallejo García; Alejandro Vallejo García; Maximiliano Parra

2007-01-01

127

Microlitiasis alveolar pulmonar/ Pulmonary alveolar microlithiasis  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish La microlitiasis alveolar pulmonar (MAP) es una enfermedad rara caracterizada por la presencia difusa y bilateral de microlitos de fosfato de calcio en el interior de los espacios alveolares. La progresión de esta enfermedad potencialmente letal, es lenta y la mayoría de los pacientes permanecen asintomáticos por años o décadas, resultando en deterioro lento de sus funciones pulmonares. El hallazgo de la radiografía de tórax en "tormenta de arena" es característic (more) o de la entidad. Recientemente se identificaron mutaciones en el gen SLC34A2, que codifica para el cotransportador tipo IIb de fosfato sódico, como responsable de la enfermedad. De los casi 600 casos, sólo seis han sido reportados en Colombia. Nosotros presentamos un caso de microlitiasis alveolar pulmonar en un hombre de 27 años, con dificultad respiratoria progresiva, cuyo diagnóstico se hizo por los hallazgos radiográficos y se confirmó por biopsia transbronquial. En el seguimiento durante dos años, evolucionó hacia el deterioro de su función respiratoria y es candidato a trasplante de pulmón. Abstract in english Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by the diffuse and bilateral presence of calcium phosphate microlite in the alveolar spaces. The progression of this potentially lethal disease is show and most of the patients remain asymptomatic during years or decades, resulting in a show deterioration of the pulmonary function. The typical finding of the "sand storm" in the chest X-ray is characteristic of this entity. Mutations in the SLC34A2 gen (more) e that does the coding for the type II co-transporter of sodium phosphate were identified as responsible for this disease. Of the almost 600 cases, only 6 have been reported in Colombia. We are presenting a case of pulmonary alveolar microlite in a 27 year old man, with progressive respiratory distress whose diagnosis was made by the X-ray findings and confirmed by trans bronchial biopsy. In the 2 years follow-up, shows evolution towards deterioration of his respiratory function making him a candidate for lung transplantation.

Vallejo García, Franco Javier; Vallejo García, Alejandro; Parra, Maximiliano

2007-12-01

128

Immunology of root resorption: A literature review  

Directory of Open Access Journals (Sweden)

Full Text Available Root resorption seems to be related to a complex combination of mechanical factors and biological activity, which comprehends the role of immunologic structures including specialized cells. The aim of this research was to explain the development of the process - from mineralization to the destruction of hard tissues - and the possible relationship between root resorption and immunology, along with discussing current concepts described in the literature.

Silva Luciano; Guimaraes Carolina; Santos Roberto

2008-01-01

129

Predisposing factors to severe external root resorption associated to orthodontic treatment  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: avaliar os fatores comuns aos pacientes que desenvolveram reabsorção radicular externa moderada ou severa (graus 3 e 4 de Malmgren) nos incisivos superiores, durante o tratamento ortodôntico fixo na dentição permanente. MÉTODOS: foram selecionados 99 pacientes que iniciaram o tratamento ortodôntico fixo com a técnica Edgewise. Os pacientes foram divididos em dois grupos: G1 - 50 pacientes que concluíram o tratamento com ausência de reabsorções radicu (more) lares ou apresentando apenas irregularidades apicais (graus 0 e 1 de Malmgren), com idade média inicial de 16,79 anos e tempo de tratamento médio de 3,21 anos; G2 - 49 pacientes que finalizaram o tratamento apresentando reabsorção radicular moderada ou severa (graus 3 e 4 de Malmgren) nos incisivos superiores, com idade média inicial de 19,92 anos e tempo de tratamento médio de 3,98 anos. As radiografias periapicais e telerradiografias foram avaliadas, além de diversos fatores que pudessem influenciar a ocorrência de uma reabsorção severa. A análise estatística incluiu o testes qui-quadrado, teste exato de Fisher e teste t independente. RESULTADOS: foi demonstrada a presença de diferença significativa entre os grupos para as variáveis realização de extrações, grau de reabsorção radicular inicial, comprimento radicular, proporção coroa/raiz e da espessura da cortical óssea alveolar. CONCLUSÃO: pode-se concluir que são fatores de risco para reabsorção radicular severa nos incisivos superiores, durante o tratamento ortodôntico, a presença de reabsorção radicular antes do início do tratamento, a realização de extrações, o comprimento radicular reduzido, a proporção coroa/raiz diminuída e a espessura óssea alveolar fina. Abstract in english OBJECTIVE: The aim of this study was to evaluate predisposing factors among patients who developed moderate or severe external root resorption (Malmgren's grades 3 and 4), on the maxillary incisors, during fixed orthodontic treatment in the permanent dentition. METHODS: Ninety-nine patients who underwent orthodontic treatment with fixed edgewise appliances were selected. Patients were divided into two groups: G1 - 50 patients with no root resorption or presenting only api (more) cal irregularities (Malmgren's grades 0 and 1) at the end of the treatment, with mean initial age of 16.79 years and mean treatment time of 3.21 years; G2 - 49 patients presenting moderate or severe root resorption (Malmgren's grades 3 and 4) at the end of treatment on the maxillary incisors, with mean initial age of 19.92 years and mean treatment time of 3.98 years. Periapical radiographs and lateral cephalograms were evaluated. Factors that could influence the occurrence of severe root resorption were also recorded. Statistical analysis included chi-square tests, Fisher's exact test and independent t tests. RESULTS: The results demonstrated significant difference between the groups for the variables: Extractions, initial degree of root resorption, root length and crown/root ratio at the beginning, and cortical thickness of the alveolar bone. CONCLUSION: It can be concluded that: Presence of root resorption before the beginning of treatment, extractions, reduced root length, decreased crown/root ratio and thin alveolar bone represent risk factors for severe root resorption in maxillary incisors during orthodontic treatment.

Picanço, Gracemia Vasconcelos; Freitas, Karina Maria Salvatore de; Cançado, Rodrigo Hermont; Valarelli, Fabricio Pinelli; Picanço, Paulo Roberto Barroso; Feijão, Camila Pontes

2013-02-01

130

Predisposing factors to severe external root resorption associated to orthodontic treatment  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVE: The aim of this study was to evaluate predisposing factors among patients who developed moderate or severe external root resorption (Malmgren's grades 3 and 4), on the maxillary incisors, during fixed orthodontic treatment in the permanent dentition. METHODS: Ninety-nine patients who underwent orthodontic treatment with fixed edgewise appliances were selected. Patients were divided into two groups: G1 - 50 patients with no root resorption or presenting only apical irregularities (Malmgren's grades 0 and 1) at the end of the treatment, with mean initial age of 16.79 years and mean treatment time of 3.21 years; G2 - 49 patients presenting moderate or severe root resorption (Malmgren's grades 3 and 4) at the end of treatment on the maxillary incisors, with mean initial age of 19.92 years and mean treatment time of 3.98 years. Periapical radiographs and lateral cephalograms were evaluated. Factors that could influence the occurrence of severe root resorption were also recorded. Statistical analysis included chi-square tests, Fisher's exact test and independent t tests. RESULTS: The results demonstrated significant difference between the groups for the variables: Extractions, initial degree of root resorption, root length and crown/root ratio at the beginning, and cortical thickness of the alveolar bone. CONCLUSION: It can be concluded that: Presence of root resorption before the beginning of treatment, extractions, reduced root length, decreased crown/root ratio and thin alveolar bone represent risk factors for severe root resorption in maxillary incisors during orthodontic treatment.OBJETIVO: avaliar os fatores comuns aos pacientes que desenvolveram reabsorção radicular externa moderada ou severa (graus 3 e 4 de Malmgren) nos incisivos superiores, durante o tratamento ortodôntico fixo na dentição permanente. MÉTODOS: foram selecionados 99 pacientes que iniciaram o tratamento ortodôntico fixo com a técnica Edgewise. Os pacientes foram divididos em dois grupos: G1 - 50 pacientes que concluíram o tratamento com ausência de reabsorções radiculares ou apresentando apenas irregularidades apicais (graus 0 e 1 de Malmgren), com idade média inicial de 16,79 anos e tempo de tratamento médio de 3,21 anos; G2 - 49 pacientes que finalizaram o tratamento apresentando reabsorção radicular moderada ou severa (graus 3 e 4 de Malmgren) nos incisivos superiores, com idade média inicial de 19,92 anos e tempo de tratamento médio de 3,98 anos. As radiografias periapicais e telerradiografias foram avaliadas, além de diversos fatores que pudessem influenciar a ocorrência de uma reabsorção severa. A análise estatística incluiu o testes qui-quadrado, teste exato de Fisher e teste t independente. RESULTADOS: foi demonstrada a presença de diferença significativa entre os grupos para as variáveis realização de extrações, grau de reabsorção radicular inicial, comprimento radicular, proporção coroa/raiz e da espessura da cortical óssea alveolar. CONCLUSÃO: pode-se concluir que são fatores de risco para reabsorção radicular severa nos incisivos superiores, durante o tratamento ortodôntico, a presença de reabsorção radicular antes do início do tratamento, a realização de extrações, o comprimento radicular reduzido, a proporção coroa/raiz diminuída e a espessura óssea alveolar fina.

Gracemia Vasconcelos Picanço; Karina Maria Salvatore de Freitas; Rodrigo Hermont Cançado; Fabricio Pinelli Valarelli; Paulo Roberto Barroso Picanço; Camila Pontes Feijão

2013-01-01

131

3D-CT evaluation of secondary alveolar bone grafts in alveolar clefts  

Energy Technology Data Exchange (ETDEWEB)

From 1994 to 2000, we treated 116 patients with cleft alveolus by secondary alveolar bone grafts, and 48 of them were evaluated morphologically with 3D-CT. The frequency of successful bony bridging was significantly higher in the group whose grafts were completely enveloped (including the anterior alveolar ridge) with a mucoperiosteal flap. The frequency was also significantly higher in the group who underwent bone grafts at the age of 13 or less, and canine eruptions did not influence the ratio. Some cases showed such an improved growth pattern of grafted bone that the shape of the affected maxilla resembled that of the normal side, after long-term follow-up observations. The growth increment was remarkable in anterior maxillary height. Orthodontic management guides the canine or incisor into the reconstructed area of the previous cleft. We surmise that the new occlusal position puts pressure on the grafted bone and promotes further osteogenesis. These findings show that it is important to produce sufficient bony bridge to guide the canine or incisor, not the volume of grafted bone, in secondary alveolar bone grafts. Long-term follow-up observation, after more than 2-3 years, is also necessary to evaluate secondary alveolar bone grafts. (author)

Naitoh, Hiroshi; Nishimura, Yoshihiko [Kyoto Univ. (Japan). Graduate School of Medicine; Yamawaki, Yoshiroh [Kyoto Katsura Hospital (Japan); Morimoto, Naoki [Kobe City General Hospital (Japan)

2002-07-01

132

Buccal bone crest dynamics after immediate implant placement and ridge preservation techniques: review of morphometric studies in animals.  

UK PubMed Central (United Kingdom)

PURPOSE: To review morphometric studies performed in animals assessing the dynamics of the buccal bone crest after immediate implant placement and ridge preservation techniques. MATERIAL AND METHOD: A bibliographic search in PubMed was performed. Studies that analyzed morphometrically in animals the buccal bone crest dynamics after immediate implant placement or ridge preservation techniques were included. Twenty-five studies met the inclusion criteria. RESULTS: Immediate implant placement does not prevent the resorption of the buccal bone crest. To minimize this resorption, 2 mm width of the buccal bone crest, palatal/lingual implant placement, and an adequate implant diameter for the width of the ridge are required. The regeneration of the gap after immediate implant placement limits the resorption of the buccal bone crest. Flap elevation and implant surface showed no relation with this resorption. Ridge preservation techniques associated with mucogingival surgery minimize buccal bone crest resorption. Biomaterials are more effective than autograft. CONCLUSIONS: Immediate implant placement does not prevent the resorption of the buccal bone crest after dental extraction. Ridge preservation techniques minimize this resorption.

Viña-Almunia J; Candel-Martí ME; Cervera-Ballester J; García-Mira B; Calvo-Guirado JL; Peñarrocha-Oltra D; Peñarrocha-Diago M

2013-04-01

133

Macrophage subsets and osteoimmunology: tuning of the immunological recognition and effector systems that maintain alveolar bone.  

UK PubMed Central (United Kingdom)

Chronic and aggressive periodontal diseases are characterized by the failure to resolve local inflammation against periodontopathogenic bacteria in the subgingival biofilm. Alveolar bone resorption is associated with altered innate and adaptive immune responses to periodontal pathogens. Macrophage-derived cytokines, chemokines and growth factors, present in both destructive and reparative phases of periodontitis, are elevated in numerous animal and human studies. Macrophage polarization to either a predominantly pro-inflammatory or anti-inflammatory phenotype may be a critical target for monitoring disease activity, modulating immune responses to subgingival biofilms in patients at risk and reducing alveolar bone loss.

Sima C; Glogauer M

2013-10-01

134

Inferior alveolar nerve damage caused by bone wax in third molar surgery.  

UK PubMed Central (United Kingdom)

The authors present a case of inferior alveolar nerve morbidity attributable to use of bone wax to control haemorrhage during third molar surgery. The patient presented after 11 symptom-free years with parasthesia and, eventually pain in the cutaneous distribution of the right inferior alveolar nerve. Radiographs revealed a 1cm radiolucency consistent with a neuroma. Pathological examination of the surgically resected lesion revealed a foreign body reaction to bone wax. The case illustrates the poor resorption qualities of bone wax and the need for other haemostatic agents to achieve haemostasis in dentoalveolar surgery.

Katre C; Triantafyllou A; Shaw RJ; Brown JS

2010-05-01

135

Inferior alveolar nerve damage caused by bone wax in third molar surgery.  

Science.gov (United States)

The authors present a case of inferior alveolar nerve morbidity attributable to use of bone wax to control haemorrhage during third molar surgery. The patient presented after 11 symptom-free years with parasthesia and, eventually pain in the cutaneous distribution of the right inferior alveolar nerve. Radiographs revealed a 1cm radiolucency consistent with a neuroma. Pathological examination of the surgically resected lesion revealed a foreign body reaction to bone wax. The case illustrates the poor resorption qualities of bone wax and the need for other haemostatic agents to achieve haemostasis in dentoalveolar surgery. PMID:20382504

Katre, C; Triantafyllou, A; Shaw, R J; Brown, J S

2010-04-10

136

Management of compromised ridges: a case report.  

UK PubMed Central (United Kingdom)

Complete denture therapy is an age old form of dental treatment. Ridge atrophy poses a clinical challenge towards the fabrication of a successful prosthesis. Extreme resorption of the maxillary and mandibular denture bearing areas results in sunken appearance of cheeks, unstable and non retentive dentures with associated pain and discomfort. This article describes the step by step rehabilitation procedure of a patient with atrophic ridges using a hollow maxillary complete denture with cheek plumpers attached to it and the recording of neutral zone to ensure a stable mandibular denture.

Manoj SS; Chitre V; Aras M

2011-06-01

137

Management of compromised ridges: a case report.  

Science.gov (United States)

Complete denture therapy is an age old form of dental treatment. Ridge atrophy poses a clinical challenge towards the fabrication of a successful prosthesis. Extreme resorption of the maxillary and mandibular denture bearing areas results in sunken appearance of cheeks, unstable and non retentive dentures with associated pain and discomfort. This article describes the step by step rehabilitation procedure of a patient with atrophic ridges using a hollow maxillary complete denture with cheek plumpers attached to it and the recording of neutral zone to ensure a stable mandibular denture. PMID:22654354

Manoj, Smita Sara; Chitre, Vidya; Aras, Meena

2011-05-27

138

Alveolar structure and function  

CERN Document Server

In the distal regions of the human lung, one of the most challenging problems facing a large multicellular organism is solved-ensuring an adequate supply of oxygen for aerobic tissue metabolism while removing associated waste products. Conduits for both air and blood converge at the alveolar level to match ventilation with perfusion and thus assure the free diffusion of oxygen and carbon dioxide. Despite their thin walls and their intimate relationship to the pulmonary capillary bed, the alveolus must present a barrier function robust enough to resist alveolar flooding from the hydrostatic pre

Payne, D Keith

2012-01-01

139

RABDOMIOSARCOMA ALVEOLAR DE UTERO  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish Los rabdomiosarcomas constituyen un tipo raro de sarcoma que se origina en las células mesenquimáticas que van a derivar en músculo estriado. De ocurrencia mayoritaria en la infancia (50-55% de los sarcomas de los niños, de ellos el 70% ocurre en la primera década). Se clasifican en forma histológica en embriones, botriodes, alveolar y pleomórficas. Estos tumores se diagnostican en raras ocasiones. Se etapifican según la IRSG de Estados Unidos. Debido a los pobres (more) resultados se evalúa la sobrevida a los 2 años (90% de mortalidad a los dos años). A continuación presentamos el poco afortunado caso de una paciente manejada en nuestro servicio, en cuyo estudio patológico se demostró un rabdomiosarcoma alveolar de útero Abstract in english Rabdomyosarcoma constitutes a rare type of sarcoma that it is originated in the mesenchymal cells that are going to derive in striated muscle. Are more common in childhood (50-55% of sarcomas of the children, of them 70% happens in a the first decade). They are classified histologicaly in embryonic, botryoid, alveolar and pleomorphic. These tumors are diagnosed very seldom. We present the unfortunate case of a patient handled in our service, in whose pathological study a uterine alveolar rhabdomyosarcoma was demonstrated

Hurel M, Ernesto; Evans M, Gregorio; Poulsen R, Ronald; Gómez P, Hugo

2003-01-01

140

RABDOMIOSARCOMA ALVEOLAR DE UTERO  

Directory of Open Access Journals (Sweden)

Full Text Available Los rabdomiosarcomas constituyen un tipo raro de sarcoma que se origina en las células mesenquimáticas que van a derivar en músculo estriado. De ocurrencia mayoritaria en la infancia (50-55% de los sarcomas de los niños, de ellos el 70% ocurre en la primera década). Se clasifican en forma histológica en embriones, botriodes, alveolar y pleomórficas. Estos tumores se diagnostican en raras ocasiones. Se etapifican según la IRSG de Estados Unidos. Debido a los pobres resultados se evalúa la sobrevida a los 2 años (90% de mortalidad a los dos años). A continuación presentamos el poco afortunado caso de una paciente manejada en nuestro servicio, en cuyo estudio patológico se demostró un rabdomiosarcoma alveolar de úteroRabdomyosarcoma constitutes a rare type of sarcoma that it is originated in the mesenchymal cells that are going to derive in striated muscle. Are more common in childhood (50-55% of sarcomas of the children, of them 70% happens in a the first decade). They are classified histologicaly in embryonic, botryoid, alveolar and pleomorphic. These tumors are diagnosed very seldom. We present the unfortunate case of a patient handled in our service, in whose pathological study a uterine alveolar rhabdomyosarcoma was demonstrated

Ernesto Hurel M; Gregorio Evans M; Ronald Poulsen R; Hugo Gómez P

2003-01-01

 
 
 
 
141

Primary pulmonary alveolar proteinosis  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction. Pulmonary alveolar proteinosis is an uncommon disease characterized by the accumulation of surfactant proteins and phospholipids within the alveolar spaces. Acquired disease can be idiopathic (primary) and secondary. The prevalence of acquired pulmonary alveolar proteinosis is about 0.37 per 100,000 persons. Common symptoms are dyspnea and cough. Chest X-ray shows bilateral perihilar infiltrates. Open-lung biopsy is the gold standard for the diagnosis. Treatment includes whole-lung lavage, application of granulocyte-macrophage colonystimulating factor and lung transplantation. Case report. We reported a 51 year-old man with primary form of the disease. It was the second case of this extremely rare disease in the past 30 years in our clinic. The symptoms were longlasting dry cough, fever and physical deterioration. Chest Xray revealed bilateral pulmonary infiltrates; computed tomography showed patchy ground-glass opacification with interlobular thickening. The diagnosis was established by open lung biopsy. Additional tests were performed to exclude secondary form of the disease. Conclusion. We presented a rare clinical entity with typical clinical features and clinical and radiological course of the disease, in order to improve differential diagnostic approach to patients with bilateral lung infiltrations. In patients with pulmonary alveolar proteinosis timely diagnosis and adequate treatment can improve a prognosis.

Šarac Sanja; Mili? Rade; Zolotarevski Lidija; A?imovi? Slobodan; Tomi? Ilija; Plavec Goran

2012-01-01

142

Orthodontic root resorption of endodontically treated teeth.  

Science.gov (United States)

The purpose of this study was to evaluate, radiographically, whether there is similarity in the apical root resorption found in endodontically treated teeth and untreated teeth when they are submitted to orthodontic treatment. From 2,500 treatment records examined, 16 patients were selected who had a maxillary central incisor treated endodontically before initiation of the orthodontic movement, and a vital homologous tooth (for control). Measurements were made by comparing the periapical radiographs taken before and after the orthodontic treatment. There was no statistically significant difference (p>0.05) in apical root resorption found in the endodontically treated teeth compared to the group of vital teeth. PMID:17258627

Esteves, Tarso; Ramos, Adilson Luiz; Pereira, Calliandra Moura; Hidalgo, Mirian Marubayashi

2006-11-22

143

Orthodontic root resorption of endodontically treated teeth.  

UK PubMed Central (United Kingdom)

The purpose of this study was to evaluate, radiographically, whether there is similarity in the apical root resorption found in endodontically treated teeth and untreated teeth when they are submitted to orthodontic treatment. From 2,500 treatment records examined, 16 patients were selected who had a maxillary central incisor treated endodontically before initiation of the orthodontic movement, and a vital homologous tooth (for control). Measurements were made by comparing the periapical radiographs taken before and after the orthodontic treatment. There was no statistically significant difference (p>0.05) in apical root resorption found in the endodontically treated teeth compared to the group of vital teeth.

Esteves T; Ramos AL; Pereira CM; Hidalgo MM

2007-02-01

144

Postextraction Ridge Preservation and Augmentation with Mineralized Allograft With or Without Recombinant Human Platelet-Derived Growth Factor BB (rhPDGF-BB): A Consecutive Case Series.  

Science.gov (United States)

In an attempt to reduce postextraction alveolar bone resorption, ridge preservation and augmentation procedures have become standard-ofcare treatment following tooth removal. This consecutive case series compares histologic and histomorphometric bone regenerative findings at 4 months following grafting for ridge preservation and augmentation in intact sockets and sockets with buccal wall defects. Sites were treated with mineralized allograft alone (control) or in combination with 0.3 mg/mL recombinant human platelet-derived growth factor BB (rhPDGF-BB) (test). Sites were allowed to heal for 4 months and then re-entered for trephine core biopsy and implant placement. At the end of 4 months, the mean percent remaining mineralized allograft was statistically significantly less in the test group than in the control group. The difference in mean percent vital bone between the groups showed a strong trend toward greater bone formation for the test group (41.8%) compared to the control group (32.5%) at the end of 4 months. Addition of growth factor signaling molecules to current grafting procedures may lead to accelerated bone regeneration, making it possible to successfully place implants at earlier time points. PMID:23998156

Wallace, Stephen C; Snyder, Mark B; Prasad, Hari

145

Multiple Congenital Epulis of the Mandibular Ridge: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Congenital epulis is a very rare benign soft-tissue tumor of uncertain histogenesis, which is also known as “gingival granular cell tumor of the newborn”. It occurs almost exclusively as a single tumor along the alveolar ridge of the maxilla in newborn females. Although congenital epulis is strikingly similar to the more common adult granular cell tumor histologically, in contrast to the latter congenital epulis cells are negative for S-100 protein. This case report describes a 15-day-old female infant with multiple congenital epulis of the mandibular alveolar ridge.

Mehran Hiradfar; Nona Zabolinejad; Mohammad Gharavi; Sadaf Sebt

2011-01-01

146

Placement of endosseous implants in grafted alveolar clefts.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The purpose of this study was to determine the optimal timing for placement and to evaluate short- and long-term outcomes of endosseous implants in bone-grafted alveolar clefts. DESIGN: Fourteen patients who underwent alveolar cleft bone grafting (ACBG) and closure of an oronasal fistula followed by restoration of the missing lateral incisor tooth using endosseous implants (EI) were studied. The oronasal fistulae were closed using local flaps, and the alveolus was grafted with fresh autogenous iliac marrow. Endosseous implants were placed a minimum of 4 months following ACBG. The average age at ACBG was 20.35 years (range, 12-65 yr), and at implant placement 22.2 years (range, 15-66 yr). It was necessary to regraft the alveolar cleft region in six patients to provide adequate bone volume for implant placement. Those who required alveolar regrafting had an increased mean interval between the initial ACBG and planned implant placement compared to the patients with adequate bone available for implant placement 26.4 months (range, 4-46 mo) versus 15.75 months (range, 4-36 mo). RESULTS: Twenty-nine implants were placed in 14 patients, 9 outside of the cleft region and 20 in grafted alveolar clefts. Eighteen of 20 (90%) implants in the bone-grafted alveolar clefts have been successfully restored. The mean follow-up after implant placement was 39.1 months (range, 1-54 mo), and after restoration 28.5 months (range, 1-47 mo). CONCLUSIONS: Endosseous implants can be placed in bone-grafted alveolar clefts. Consideration should be given to the adequacy of graft volume and ridge morphology at the time of ACBG. The interval between ACBG and implant placement is important. The greater the interval beyond 4 months, the more likely there will be inadequate bone volume to accept an implant.

Kearns G; Perrott DH; Sharma A; Kaban LB; Vargervik K

1997-11-01

147

Matrix metalloproteinase-9 regulates graft bone resorption  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Objective: To explore the relationship between bone resorption and matrix metalloproteinase-9 (MMP-9) expression in autogenous and allogenic bone grafts. Materials and Methods: A total of 18 critical-size (10 x 15 mm) defects were created in rabbit mandibles bilaterally. Three groups of six defects ...

Lu, M; Rabie, ABM

148

Internal and external root resorption: aetiology, diagnosis and treatment options.  

UK PubMed Central (United Kingdom)

UNLABELLED: Root resorption is a pathological process that may occur after surgical, mechanical, chemical or thermal insult. Generally, it can be classified as internal and external root resorption. Depending on the diagnosis, an orthograde, surgical or a combined approach is used in management of these cases. CLINICAL RELEVANCE: General dental practitioners can face difficulties in diagnosis and treatment planning for cases with root resorption. An understanding of the aetiology and pathogenesis of root resorption is critical for diagnosis, effective management and improves outcome.

Al-Momani Z; Nixon PJ

2013-03-01

149

Pulmonary alveolar microlithiliasis  

International Nuclear Information System (INIS)

[en] We report a patient with plmonary alveolar microlithiliasis who was admitted to King Abdul-Aziz Hospital, Makkah, Kingdom of Saudi Arabia with chest pain, shortness of breath dry cough and swelling of lower limbs.The patient underwent chest radiolgraphs and computerized tomography scan showing multiple diffuse, almost symmetrical bilateral micronodulor opacities of calicific density. The diagnosis was confirmed after percuraneous lung biopsy from the patient. Cardiokinetics, diuretics and oxygen were administerd with slight improvement. (author)

2004-01-01

150

Combined Osteotome-Induced Ridge Expansion and Guided Bone Regeneration Simultaneous with Implant Placement: A Biometric Study.  

UK PubMed Central (United Kingdom)

PURPOSE: To evaluate the long-term outcome of a single-step ridge expansion osteotome procedure and implant placement combined with guided bone regeneration in patients presenting narrow maxillary alveolar ridges. MATERIALS AND METHODS: During the period 1999 to 2010, 41 patients aged 19 to 77 years (18 males; 23 females) suffering from partial or full edentulism associated with horizontal resorption of the maxillary ridges (2.5-5?mm) were treated using the combined ridge expansion and guided bone-regeneration techniques to obtain an improved bony base for implant placement. Implant survival, bone width measurements, clinical and radiologic implant success, and clinical complications were recorded and analyzed. RESULTS: Achievement of primary stability of the implant was impossible at six sites; these were recorded as failures. In the remaining 35 patients, one hundred sixteen endosseous titanium implants were simultaneously placed. Follow-up time varied between 6 and 144 months (mean 52.4); of these, 36% were followed up for periods of time longer than 60 months. Implant diameter and lengths varied between 3.3 to 4.8 and 12 to 16?mm, respectively. In the 35 successful procedures (one hundred sixteen implants), the overall implant survival rate was 100%. An average gain in ridge width was 3.5?±?0.93 (p?ridge expansion and guided bone regeneration simultaneous with implant placement is a reliable procedure with reduced morbidity and may offer an alternative in suitable situations.

Kolerman R; Nissan J; Tal H

2013-01-01

151

Combined Osteotome-Induced Ridge Expansion and Guided Bone Regeneration Simultaneous with Implant Placement: A Biometric Study.  

Science.gov (United States)

PURPOSE: To evaluate the long-term outcome of a single-step ridge expansion osteotome procedure and implant placement combined with guided bone regeneration in patients presenting narrow maxillary alveolar ridges. MATERIALS AND METHODS: During the period 1999 to 2010, 41 patients aged 19 to 77 years (18 males; 23 females) suffering from partial or full edentulism associated with horizontal resorption of the maxillary ridges (2.5-5?mm) were treated using the combined ridge expansion and guided bone-regeneration techniques to obtain an improved bony base for implant placement. Implant survival, bone width measurements, clinical and radiologic implant success, and clinical complications were recorded and analyzed. RESULTS: Achievement of primary stability of the implant was impossible at six sites; these were recorded as failures. In the remaining 35 patients, one hundred sixteen endosseous titanium implants were simultaneously placed. Follow-up time varied between 6 and 144 months (mean 52.4); of these, 36% were followed up for periods of time longer than 60 months. Implant diameter and lengths varied between 3.3 to 4.8 and 12 to 16?mm, respectively. In the 35 successful procedures (one hundred sixteen implants), the overall implant survival rate was 100%. An average gain in ridge width was 3.5?±?0.93 (p?ridge expansion and guided bone regeneration simultaneous with implant placement is a reliable procedure with reduced morbidity and may offer an alternative in suitable situations. PMID:23350624

Kolerman, Roni; Nissan, Joseph; Tal, Haim

2013-01-25

152

Radiographic evaluation of apical root resorption following fixed orthodontic treatment  

Directory of Open Access Journals (Sweden)

Full Text Available Background and Aims: Apical root resorption is an adverse side effect of fixed orthodontic treatment which cannot be repaired. The aim of this study was to use panoramic radiographs to compare the root resorption before and after the orthodontic treatment with standard edgewise .018 appliance.Materials and Methods: The before and after treatment panoramic views of sixty-three patients needed fixed orthodontic treatment included 1520 teeth were categorized into 3 Grades (G0: without resorption, G1: mild resorption with blunt roots or ? 1/4 of root length, G2: moderate to severe resorption or > 1/4 to 1/2 of root length. Relationship between root resorption and sex and treatment duration was analyzed with Mann-whitney and Spearman's correlation coefficient, respectively.Results: The findings showed that 345 teeth were categorized as Grade 1. Grade 2 of root resorption was not found in this study. The highest amount of root resorption was recorded for the mandibular lateral incisor. In both gender, the root resorption of the mandible was more than that of the maxilla. The males showed significantly higher rate of resorption than the females (P0.05).Conclusion: The mandible and male patients showed higher amount of root resorption. In addition, root resorption was not related to the treatment duration and the side of the jaws.

Sina Haghanifar; Valiollah Arash; Farhad Soboti; Nasim Jafari

2012-01-01

153

Stoichiometric patterns in foliar nutrient resorption across multiple scales.  

UK PubMed Central (United Kingdom)

• Nutrient resorption is a fundamental process through which plants withdraw nutrients from leaves before abscission. Nutrient resorption patterns have the potential to reflect gradients in plant nutrient limitation and to affect a suite of terrestrial ecosystem functions. • Here, we used a stoichiometric approach to assess patterns in foliar resorption at a variety of scales, specifically exploring how N : P resorption ratios relate to presumed variation in N and/or P limitation and possible relationships between N : P resorption ratios and soil nutrient availability. • N : P resorption ratios varied significantly at the global scale, increasing with latitude and decreasing with mean annual temperature and precipitation. In general, tropical sites (absolute latitudes < 23°26') had N : P resorption ratios of < 1, and plants growing on highly weathered tropical soils maintained the lowest N : P resorption ratios. Resorption ratios also varied with forest age along an Amazonian forest regeneration chronosequence and among species in a diverse Costa Rican rain forest. • These results suggest that variations in N : P resorption stoichiometry offer insight into nutrient cycling and limitation at a variety of spatial scales, complementing other metrics of plant nutrient biogeochemistry. The extent to which the stoichiometric flexibility of resorption will help regulate terrestrial responses to global change merits further investigation.

Reed SC; Townsend AR; Davidson EA; Cleveland CC

2012-10-01

154

Clinical and histological evaluation of alloderm GBR and BioOss in the treatment of Siebert's class I ridge deficiency  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Complete prosthetic rehabilitation using implants require the presence of adequate dimensions of alveolar bone. Ridge augmentation procedures include the use of guided bone regeneration (GBR) procedures where the barrier membrane provides cell occlusion and space for the regenerating tissues. Allode...

Sudarsan, Sabitha; Arun, K. V.; Priya, M. S.; Arun, Ramya

155

Pulmonary alveolar microlithiasis.  

UK PubMed Central (United Kingdom)

This is a case report of 32 years old male, who presented in outdoor clinic of Pulmonology Department, Jinnah Hospital, Lahore, with progressively increasing shortness of breath over 2 years, multiple episodes of dry cough over 9 months, history of low-grade fever for 15 days and haemoptysis for the last one day. He was diagnosed as a case of miliary tuberculosis on the basis of his chest X-ray findings and was on anti-tuberculosis treatment by the GP of the locality. Diagnosis of pulmonary alveolar microlithiasis was made on the basis of clinical features and laboratory findings.

Saleem A; Chaudhary A; Iqbal ZH

2009-06-01

156

Feline dental resorptive lesions. Prevalence patterns.  

UK PubMed Central (United Kingdom)

Surveys were carried out in cats presented for dental examination in the Netherlands (432 cats) and in the United States (78 cats). In 62% of the Dutch cats and 67% of the US cats, resorptive lesions were present. In the Dutch study, Asian Short-hair (principally Siamese) cats were most commonly involved, and male cats were more commonly affected than females. The most commonly affected teeth were the fourth maxillary premolar and the mandibular premolar and molar teeth.

van Wessum R; Harvey CE; Hennet P

1992-11-01

157

Association of type 2 diabetes mellitus with the reduction of mandibular residual ridge among edentulous patients using panoramic radiographs  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To evaluate the association between type 2 diabetes mellitus and the reduction of mandibular residual ridge in completely edentulous patients wearing complete dentures and to investigate the ef-fect of gender, age and years of edentulousness / den-ture wearing on ridge resorption on both groups. Methods:Seventy-two (36 men and 36 women) with a mean age 63.5 years (range of 52 to 73 years) com-pletely edentulous denture-wearing patients were included in this study. Of these, there were 40 patients with type 2 diabetes mellitus and 32 control subjects participated in the study. Resorption in the mandibular residual ridges was assessed by using the mental foramen and the inferior border of the mandible, as they appear in panoramic radiographs, as reference points using Wical and Swoope Analysis method. Measurements were performed using “Dijite” Digital Caliper. The amount of mandibular ridge resorption was calculated and correlated with type 2 diabetes mellitus and the results were compared with control group. Differences in gender, age and years of edentulousness were investigated. Statistical analysis was performed using SPSS (V11.0). A 2-sample t-test was used to evaluate the differences in mean values of mandibular ridge resorption between diabetics and controls. Level of significance was set at 0.05. Results: The mean mandibular residual ridge resorption of all participants is 8.0 mm (26.9%), diabetic group significantly (P < 0.01) had two times more resorption compared with control group (35.8% versus 18.0%). Females recorded greater amount of resorption in diabetics 49.7% versus 21.8% (P < 0.001) and in controls 22.3% versus 13.7%, (P < 0.05) compared to males, respectively. There were no differences in both groups regarding the age of subjects and the length of time they have been edentulous and years of denture wearing. The amount of mandibular residual ridge resorption was directly related to the number of years of edentulousness. Conclusion: Completely edentulous, denture-wearing diabetics, women in particular, are at more risk to have ridge resorption than “nondiabetic” subjects. Reduced mandibular height is directly related to years of edentulousness and denture wear-ing with greater amount of resorption among diabet-ics.

Osama Al-Jabrah

2011-01-01

158

Diffuse alveolar hemorrhage.  

UK PubMed Central (United Kingdom)

Diffuse alveolar hemorrhage (DAH) is a life-threatening and medical emergency that can be caused by numerous disorders and presents with hemoptysis, anemia, and diffuse alveolar infiltrates. Early bronchoscopy with bronchoalveolar lavage is usually required to confirm the diagnosis and rule out infection. Most cases of DAH are caused by capillaritis associated with systemic autoimmune diseases such as anti-neutrophil cytoplasmic antibody-associated vasculitis, anti-glomerular basement membrane disease, and systemic lupus erythematosus, but DAH may also result from coagulation disorders, drugs, inhaled toxins, or transplantation. The diagnosis of DAH relies on clinical suspicion combined with laboratory, radiologic, and pathologic findings. Early recognition is crucial, because prompt diagnosis and treatment is necessary for survival. Corticosteroids and immunosuppressive agents remain the gold standard. In patients with DAH, biopsy of involved sites can help to identify the cause and to direct therapy. This article aims to provide a general review of the causes and clinical presentation of DAH and to recommend a diagnostic approach and a management plan for the most common causes.

Park MS

2013-04-01

159

Congenital granular cell tumor of the alveolar ridge  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Congenital epulis or neonatal granular cell tumor is a tumor whose histogenesis has long been debated. It is dissimilar to other granular cell tumors; the latter having derivation from Schwann cells and hence being S-100 positive. We report a case of congenital granular cell tumor in a newborn femal...

Dhingra Meetu; Pantola Chayanika; Agarwal Asha

160

Congenital granular cell tumor of the alveolar ridge  

Directory of Open Access Journals (Sweden)

Full Text Available Congenital epulis or neonatal granular cell tumor is a tumor whose histogenesis has long been debated. It is dissimilar to other granular cell tumors; the latter having derivation from Schwann cells and hence being S-100 positive. We report a case of congenital granular cell tumor in a newborn female child that was uneventfully operated. The case is reported here because of its rarity.

Dhingra Meetu; Pantola Chayanika; Agarwal Asha

2010-01-01

 
 
 
 
161

Management of alveolar clefts.  

UK PubMed Central (United Kingdom)

Treatment philosophies in the management of alveolar clefts have changed greatly over the years. Currently. the most widely accepted protocol is for repair using autologous cancellous bone from the iliac crest during the stage of mixed dentition. Preliminary data suggest that the appropriate age for surgical repair during the secondary phase can be decreased without evidence of limitation of facial growth. Further long-term studies are necessary to support this protocol, however. With a multidisciplinary approach between the various medical and dental specialties, it is now commonplace to achieve normal dentofacial aesthetics and function. The continued advances in medical and dental technology have further contributed to the excellent outcomes that are now achieved.

Daw JL Jr; Patel PK

2004-04-01

162

Alveolar bone grafting  

Directory of Open Access Journals (Sweden)

Full Text Available In patients with cleft lip and palate, bone grafting in the mixed dentition in the residual alveolar cleft has become a well-established procedure. The main advantages can be summarised as follows: stabilisation of the maxillary arch; facilitation of eruption of the canine and sometimes facilitation of the lateral incisor eruption; providing bony support to the teeth adjacent to the cleft; raising the alar base of the nose; facilitation of closure of an oro-nasal fistula; making it possible to insert a titanium fixture in the grafted site and to obtain favourable periodontal conditions of the teeth within and adjacent to the cleft. The timing of the ABG surgery take into consideration not only eruption of the canine but also that of the lateral incisor, if present. The best time for bone grafting surgery is when a thin shell of bone still covers the soon erupting lateral incisor or canine tooth close to the cleft.

Lilja Jan

2009-01-01

163

Alveolar soft-part sarcoma  

Energy Technology Data Exchange (ETDEWEB)

Alveolar soft-part sarcoma usually arises from the soft tissue of the lower extremity, but may arise from the orbit, retroperitoneum and else where, in both children and adults. The tumors grow slowly, may invade the underlying bone, and eventually may metastasis widely through the blood stream. Recently, we experienced 5 cases of alveolar soft-part sarcoma originated from thigh, lower leg, inguinal region, retroperitoneum and orbit. The radiologic findings are soft tissue mass (2 cases) with underlying bony destruction (3 cases), lung metastasis (2 cases). Although rare, alveolar soft-part sarcoma should be included in the differential diagnosis of soft tissue tumor arising from the lower extremity.

Jung, Seung Hyae; Sung, Dong Wook; Yoon, Yup; Choi, Woo Suk; Lim, Jae Hoon; Yang, Moon Ho [College of Medicine, Kyunghee Univ., Seoul (Korea, Republic of)

1990-10-15

164

Alveolar soft-part sarcoma  

International Nuclear Information System (INIS)

Alveolar soft-part sarcoma usually arises from the soft tissue of the lower extremity, but may arise from the orbit, retroperitoneum and else where, in both children and adults. The tumors grow slowly, may invade the underlying bone, and eventually may metastasis widely through the blood stream. Recently, we experienced 5 cases of alveolar soft-part sarcoma originated from thigh, lower leg, inguinal region, retroperitoneum and orbit. The radiologic findings are soft tissue mass (2 cases) with underlying bony destruction (3 cases), lung metastasis (2 cases). Although rare, alveolar soft-part sarcoma should be included in the differential diagnosis of soft tissue tumor arising from the lower extremity.

1990-01-01

165

Root resorption following treatment with aligners.  

Science.gov (United States)

Can orthodontically induced inflammatory root resorption (OIIRR) be the result of Invisalign treatment? Since OIIRR was first described in the literature, orthodontists have been looking for a treatment procedure where no root shortening will occur. In the past decade, Invisalign orthodontic treatment has become very popular, and there is no description of OIIRR after this treatment. Therefore, it might be incorrectly concluded that the body is immune to this type of orthodontic treatment modality and no OIIRR appears as a result of this treatment. The following case report demonstrates an aspect of the complexity of OIIRR. PMID:18947291

Brezniak, Naphtali; Wasserstein, Atalia

2008-11-01

166

Root resorption following treatment with aligners.  

UK PubMed Central (United Kingdom)

Can orthodontically induced inflammatory root resorption (OIIRR) be the result of Invisalign treatment? Since OIIRR was first described in the literature, orthodontists have been looking for a treatment procedure where no root shortening will occur. In the past decade, Invisalign orthodontic treatment has become very popular, and there is no description of OIIRR after this treatment. Therefore, it might be incorrectly concluded that the body is immune to this type of orthodontic treatment modality and no OIIRR appears as a result of this treatment. The following case report demonstrates an aspect of the complexity of OIIRR.

Brezniak N; Wasserstein A

2008-11-01

167

Orthodontically induced root resorption correlated with morphological characteristics.  

UK PubMed Central (United Kingdom)

UNLABELLED: Orthodontically induced root resorption is an irreversible process that can have medical, ethical and legal implications. AIM: The objective of this research was to identify morphological risk factors, in order to prevent it. MATERIAL AND METHODS: We realized a retrospective study on 50 patients and made correlation between the prevalence and gravity of radiological identified root resorption and multiple biological and anatomical features. RESULTS AND CONCLUSIONS: We found that, when removable orthodontic appliances were used, there were not found root resorption (0%), and in cases in which fixed appliances were used, the root resorption was found, and it generally presented a high prevalence (96%) and low severity. Prevalence of root resorption is influenced by the sex and age of the patients (is greater for males than for females and higher in older patients). Topographically, differences were found in prevalence of root resorption (79.33% in mandibullary frontal teeth and 74% in the maxillary ones). The highest prevalence of root resorption was found in the lower central incisor (86%). Prevalence of root resorption is higher when there are alterations of the normal anatomy (facial hypo- or hyperdivergence, Angle class II and III malocclusion, angulated roots). Some anatomical aspects may present a fact of prevision of the appearance of root resorption within the orthodontic treatment.

Preoteasa CT; Ionescu E; Preoteasa E; Comes CA; Buzea MC; Gr?mescu A

2009-01-01

168

Scanning electron microscopy of root resorption of feline teeth.  

UK PubMed Central (United Kingdom)

Scanning electron microscopy was carried out on 10 feline extracted permanent teeth from 3 cases with root resorption. Various-sized resorption lacunae were well defined, showing an etched pattern and configuration as shown in human deciduous teeth. In cats, regardless of the shape and depth of lacunae, the resorption lacunae showed opening dentinal tubules in the wall with or without cement matrix apperring only in the deep and round lacunae of human cases. Some specific process of mineralization for repairing dental root resorption was suggested in cats.

Ohba S; Kuwabara M; Kamata H; Yukawa M; Kiba H

2004-12-01

169

Transition and determinants of orthodontic root resorption-repair sequence.  

UK PubMed Central (United Kingdom)

When severe root resorption is observed during orthodontic treatment the clinician needs to know how the active process can be stopped. It is generally assumed that if active force is discontinued, the root resorption will end. The determinants of the resorption/repair sequence are, however, not well understood. The aim of the present study was to register and analyse determinants that may influence the extent of resorbed root surface, as well as the transition of a process of active root resorption into a process of tissue deposition/repair in the resorption lacunae. Using an experimental model that would simulate the first force-activation cycle, the upper first molars of rats were moved mesially by a fixed orthodontic appliance for periods between 2 and 21 days. The results revealed that (1) the extent of root resorption after 21 days corresponded with the maximal extent of the hyalinized zone; (2) a process of repair started from the periphery in the resorbed lacunae where the periodontal ligament (PDL) had been re-established, while ongoing active resorption was observed beneath the existing hyalinized tissue; and (3) root resorption continued in the area where hyalinized tissue persisted even after active force had terminated. It is hypothesized that determinants of continued resorption/repair generally seem to be associated with the persistence and removal of the necrotic tissue.

Brudvik P; Rygh P

1995-06-01

170

Transition and determinants of orthodontic root resorption-repair sequence.  

Science.gov (United States)

When severe root resorption is observed during orthodontic treatment the clinician needs to know how the active process can be stopped. It is generally assumed that if active force is discontinued, the root resorption will end. The determinants of the resorption/repair sequence are, however, not well understood. The aim of the present study was to register and analyse determinants that may influence the extent of resorbed root surface, as well as the transition of a process of active root resorption into a process of tissue deposition/repair in the resorption lacunae. Using an experimental model that would simulate the first force-activation cycle, the upper first molars of rats were moved mesially by a fixed orthodontic appliance for periods between 2 and 21 days. The results revealed that (1) the extent of root resorption after 21 days corresponded with the maximal extent of the hyalinized zone; (2) a process of repair started from the periphery in the resorbed lacunae where the periodontal ligament (PDL) had been re-established, while ongoing active resorption was observed beneath the existing hyalinized tissue; and (3) root resorption continued in the area where hyalinized tissue persisted even after active force had terminated. It is hypothesized that determinants of continued resorption/repair generally seem to be associated with the persistence and removal of the necrotic tissue. PMID:7542608

Brudvik, P; Rygh, P

1995-06-01

171

Submergence of vital roots for the preservation of residual ridge: a clinical study.  

UK PubMed Central (United Kingdom)

PURPOSE: To test the value of submerging vital roots for the preservation of the residual ridge. MATERIALS AND METHODS: The study sample consisted of 10 patients whose bone height on both submerged and control sites was measured with the help of OPG tracings and the use of grids, from the immediate post-operative period to 3 months, 6 months and 9 months post-operatively. Statistical analysis was performed using the t-test and one-way ANOVA. RESULTS: The amount of bone loss was significantly greater in the control area in comparison to the submerged area from the immediate post-operative period to 3 months, 6 months and 9 months post-operatively. CONCLUSION: Although the retained roots do not prevent the resorption of residual ridge, they aid in decreasing the resorptive pattern, thereby preserving the residual ridge to some extent. This may be an expedient and inexpensive way to preserve residual ridge, requiring minimal specialised training.

Sharma A; Oberoi SS; Saxena S

2012-01-01

172

Vertical ridge augmentation using titanium mesh.  

UK PubMed Central (United Kingdom)

With tooth loss, there is increased bone loss of the alveolus. In some cases alveolar bone loss can be severe. Severe bone loss may cause difficulty for patients wearing a conventional prosthesis or being restored with dental implants. Severe alveolar bone loss can result in malnutrition, poor self-esteem, multiple dental visits for failed prosthesis, and jaw fracture. In many cases, patients with loss of alveolar bone height or width may require reconstructive procedures. Vertical ridge augmentation remains a challenge in the reconstruction of the atrophic maxilla and mandible. The main problem arises from the need to expand the soft-tissue envelope and achieve the proper bony architecture. Techniques that have been developed to solve or circumvent this problem include onlay bone grafting with particulate bone graft, block bone graft, barrier techniques with permanent or resorbable membranes, distraction osteogenesis, vascularized ridge splitting techniques, sinus lifts, nerve repositioning techniques, short implants, and angled implants. All of these techniques have advantages and disadvantages. This article focuses on augmentation procedures using titanium mesh, which acts as a barrier and physical support of the soft tissue over the bone graft.

Louis PJ

2010-08-01

173

Vertical ridge augmentation using titanium mesh.  

Science.gov (United States)

With tooth loss, there is increased bone loss of the alveolus. In some cases alveolar bone loss can be severe. Severe bone loss may cause difficulty for patients wearing a conventional prosthesis or being restored with dental implants. Severe alveolar bone loss can result in malnutrition, poor self-esteem, multiple dental visits for failed prosthesis, and jaw fracture. In many cases, patients with loss of alveolar bone height or width may require reconstructive procedures. Vertical ridge augmentation remains a challenge in the reconstruction of the atrophic maxilla and mandible. The main problem arises from the need to expand the soft-tissue envelope and achieve the proper bony architecture. Techniques that have been developed to solve or circumvent this problem include onlay bone grafting with particulate bone graft, block bone graft, barrier techniques with permanent or resorbable membranes, distraction osteogenesis, vascularized ridge splitting techniques, sinus lifts, nerve repositioning techniques, short implants, and angled implants. All of these techniques have advantages and disadvantages. This article focuses on augmentation procedures using titanium mesh, which acts as a barrier and physical support of the soft tissue over the bone graft. PMID:20713268

Louis, Patrick J

2010-08-01

174

Alveolar proteinosis in Behçet's disease  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract A 51-year-old man with Behçet's disease complained of fever, dry cough and dyspnea during exertion. Chest CT showed ground glass opacities with interstitial septal thickening in both lungs. Bronchoalveolar lavage (BAL) revealed amorphous and lipoproteinaceous material that was periodic acid-Schiff (PAS) stain positive. Transbronchial biopsy specimen demonstrated PAS positive alveolar eosinophilic material consistent with pulmonary alveolar proteinosis. Serum anti-granulocyte-macrophage colony stimulating factor (GM-CSF) antibody was negative. Recent studies have reported anti-GMCSF not present in the the serum of patients with secondary pulmonary alveolar proteinosis (PAP) but they have not reported so in patients with idiopathic PAP. We report a case of alveolar proteinosis in the setting of Behçet's disease with spontaneous remission.

Tetikkurt Cuneyt; Tetikkurt Seza; Ozdemir Imran; Zuhur Cigdem; Bayar Nihal

2010-01-01

175

Inferior alveolar nerve lateral transposition.  

UK PubMed Central (United Kingdom)

PURPOSE: We determined the outcomes of 18 inferior alveolar nerve lateral transposition procedures in 15 consecutive patients. The advantages and disadvantages of this technique are discussed. RESULTS: The surgical protocol for inferior alveolar nerve transposition, followed by implant placement, presented excellent results, with complete recovery of the sensitivity within 6 months after the surgical procedure. DISCUSSION: Inferior alveolar nerve transposition is an option for prosthetic rehabilitation in cases of moderate or even severe bone reabsorption for patients that do not tolerate removable dentures. CONCLUSIONS: It is concluded that inferior alveolar nerve transposition can be safely and predictably performed with low risk to the mental nerve sensibility. Each patient should be advised of the chance of permanent nerve deficit throughout the distribution of the mental nerve. Alternative restorative solutions should also be considered.

Chrcanovic BR; Custódio AL

2009-12-01

176

Proteinosis alveolar pulmonar, caso clínico  

Scientific Electronic Library Online (English)

Full Text Available Abstract in spanish La Proteinosis Alveolar Pulmonar es una patología poco frecuente, especialmente en la edad pediátrica, caracterizada por acumulación de material lipoproteináceo proveniente del surfactante en los macrófagos alveolares. Objetivo: Comunicar un caso de proteinosis pulmonar en el cual el uso de la fibrobroncoscopía (FB) permitió el diagnóstico y el tratamiento. Caso Clínico: Escolar de 7 años, que consulta por un cuadro febril, en la cual se plantea inicialmente el (more) diagnóstico de neumonía. Ante la mala evolución, con aumento de las imágenes radiológicas de tipo nodular, el ascenso de los niveles de LDH en plasma, y la mínima sintomatología clínica respiratoria, se planteó el diagnóstico de proteinosis alveolar, realizando una FB con lavado alveolar. Las tinciones de Sudán y PAS confirmaron la sospecha diagnóstica, lo cual fue apoyado por la mejoría radiológica y clínica de la paciente. Discusión: Se discute las formas clínicas de presentación, los hallazgos clínicos, radiológicos y de laboratorio que permiten plantear el diagnóstico. Se destaca el rol de la fibrobroncoscopía como método diagnóstico y terapéutico Abstract in english Pulmonary Alveolar Proteinosis. Case-report Pulmonary alveolar proteinosis is a rare pathology in children, characterized by the presence of lipoprotein material becoming from surfactants in alveolar macrophages. Objetive: Describe a clinical case of pulmonary proteinosis, in which fibrobronchoscopy (FB) allowed diagnosis and treatment. Case-report: A 7 years-old boy with fever and diagnostic presumption of pneumonia. The evolution was not favorable, in terms of increase (more) in nodular images on chest X-ray and increase in LDH plasmatic level, with few respiratory symptoms. The diagnosis of pulmonary alveolar proteinosis was suspected, performing a FB with bronchoalveolar lavage, where Sudán and PAS colouring confirmed the diagnosis. Discussion: Analysis of clinical presentations, laboratory findings and chest images that suggest the diagnosis. It is important to point out the role of FB in diagnosis and treatment

PARAM S, TERESA; FLORES S, MANUEL; BOLBARAN S, JUAN PABLO; DÍAZ C, ARMANDO; ACUÑA H, JUAN CARLOS; OCHOA M, LAURA

2007-04-01

177

Tooth resorption in cats : contribution of vitamin D and inflammation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Tooth resorption affecting several teeth is a painful disease with a prevalence of up to 75% in household cats and is often accompanied by periodontitis. Tooth resorption is caused by an increased number and activity of tooth-resorbing odontoclasts, cells that share functional characteristics with b...

Vrieling, H.E.

178

Study of the relationship between the indication rod of stent on implant CT and the real path of implant fixture insertion considering residual ridge  

Energy Technology Data Exchange (ETDEWEB)

To assess the relationship between the direction of the indicating rod of the radiographic stent for ideal prosthetic design and the actual possible path of implant fixture placement when residual ridge resorption is considered. The study materials considered of 326 implant sites (male 214 cases and female 112 cases) from a total of 106 patients (male 65 patients and female 41 patients) who desired implant prostheses. Computed tomography of patients were taken and reformatted using ToothPix software. Bony defects, bony sclerosis, the change of the direction of indicating rod, and root proximity of the adjacent teeth were examined on the CT-derived images. The rate of the irregular crestal cortex was relatively high on premolar and molar area of maxilla. Mandibular molar area showed relatively high rate of focal sclerosis on the area of implant fixture insertion. The position of the including rods were relatively acceptable on the molar areas of both jaws. However, the position of the indicating rods should be shifted to buccal side with lingual rotation of the apical end on maxillary anterior teeth and premolar area. Clinically determined rod direction and position of the indicating rod for implant placement was not always acceptable for insertion according to the reformatted CT images. The pre-operative treatment plan for implant should be determined carefully, considering the state of the alveolar bone using the reformatted CT images.

Kim, Do Hoon; Heo, Min Suk; Lee, Sam Sun; Oh, Sung Ook; Choi, Soon Chul [Seoul National University College of Medicine, Seoul (Korea, Republic of); Choi, Hang Moon [Kangnung National University College of Medicine, Kangnung (Korea, Republic of); Jeon, In Seong [Inje University Sanggyepaik Hospital, Seoul (Korea, Republic of)

2003-06-15

179

Proteinases in bone resorption : obvious and less obvious roles  

DEFF Research Database (Denmark)

Bone resorption is critical for the development and the maintenance of the skeleton, and improper regulation of bone resorption leads to pathological situations. Proteinases are necessary for this process. In this review, we show that this need of proteinases is not only because they are required for the solubilization of bone matrix, but also because they are key components of the mechanism that determines where and when bone resorption will be initiated. Moreover, there are indications that proteinases may also determine whether resorption will be followed by bone formation. Some of the proteinases involved in these different steps of the resorption processes were recently identified, as for instance cathepsin K, MMP-9 (gelatinase B), and interstitial collagenase. However, there is also increasing evidence showing that the critical proteinase(s) may vary depending on the bone type or on other factors.

Delaissé, Jean-Marie; Engsig, M T

2000-01-01

180

Root resorption of replanted teeth: an SEM study.  

Science.gov (United States)

Two replanted and subsequently expelled upper central incisors were observed under a scanning electron microscope to study the changes brought about by root resorption. The severity of resorption and the distribution of the affected areas were different in the two specimens. In the first case, large, deep excavations were found along a continuous bone defect which exposed the opposite root canal wall. Bacteria-like elements were found on the bottom of the eroded areas both on the outer and on the inner root surfaces. In the second case, resorption denuded the apical portion of the metal post. Erosive lacunae were visible in some areas while tubiform excavations were present close to the apical margin exposing the collagen network. The roots in the first case likely underwent inflammatory resorption while replacement resorption was thought to have occurred in the second case. PMID:9863425

Pettini, F; Pettini, P

1998-06-01

 
 
 
 
181

Root resorption of replanted teeth: an SEM study.  

UK PubMed Central (United Kingdom)

Two replanted and subsequently expelled upper central incisors were observed under a scanning electron microscope to study the changes brought about by root resorption. The severity of resorption and the distribution of the affected areas were different in the two specimens. In the first case, large, deep excavations were found along a continuous bone defect which exposed the opposite root canal wall. Bacteria-like elements were found on the bottom of the eroded areas both on the outer and on the inner root surfaces. In the second case, resorption denuded the apical portion of the metal post. Erosive lacunae were visible in some areas while tubiform excavations were present close to the apical margin exposing the collagen network. The roots in the first case likely underwent inflammatory resorption while replacement resorption was thought to have occurred in the second case.

Pettini F; Pettini P

1998-06-01

182

Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption  

DEFF Research Database (Denmark)

Patients with defective osteoclastic acidification have increased numbers of osteoclasts, with decreased resorption, but bone formation that remains unchanged. We demonstrate that osteoclast survival is increased when acidification is impaired, and that impairment of acidification results in inhibition of bone resorption without inhibition of bone formation. We investigated the role of acidification in human osteoclastic resorption and life span in vitro using inhibitors of chloride channels (NS5818/NS3696), the proton pump (bafilomycin) and cathepsin K. We found that bafilomycin and NS5818 dose dependently inhibited acidification of the osteoclastic resorption compartment and bone resorption. Inhibition of bone resorption by inhibition of acidification, but not cathepsin K inhibition, augmented osteoclast survival, which resulted in a 150 to 300% increase in osteoclasts compared to controls. We investigated the effect of inhibition of osteoclastic acidification in vivo by using the rat ovariectomy model withtwice daily oral dosing of NS3696 at 50 mg/kg for 6 weeks. We observed a 60% decrease in resorption (DPYR), increased tartrate-resistant acid phosphatase levels, and no effect on bone formation evaluated by osteocalcin. We speculate that attenuated acidification inhibits dissolution of the inorganic phase of bone and results in an increased number of nonresorbing osteoclasts that are responsible for the coupling to normal bone formation. Thus, we suggest that acidification is essential for normal bone remodeling and that attenuated acidification leads to uncoupling with decreased bone resorption and unaffected bone formation.

Karsdal, Morten A; Henriksen, Kim Steen

2005-01-01

183

[Initial stress in the periodontal membrane of maxillary first molar with different alveolar bone height by intrusion: 3-dimensional finite element analysis].  

UK PubMed Central (United Kingdom)

PURPOSE: To establish the 3-D finite element models of maxillary first molar, and calculate the stress magnitude and distribution within the PDL of maxillary first molar when loaded with intrusion force. METHODS: Date from CT scanning image of the maxillary first molar was used to establish the 3-D finite element model of maxillary first molar. By simulating the horizontal unbalanced bone resorption model sequentially, the magnitude and distribution of PDL stress at these models were calculated under intrusion force. RESULTS: The 3-D finite element models of maxillary first molar were constructed. With constant decrease of alveolar bone height, stress of the PDL increased non-linearly. The stress in PDL changed slowly when alveolar bone height reduced from normal level to 3.5 mm, but it increased dramatically when the height of alveolar bone resorption exceeded 6.0 mm and root furcation was exposed. The high-stress concentrated in root furcation of maxillary first molar when root furcation had not been exposed, and it would be transfered to apex or one third of root length when root furcation had been exposed. CONCLUSIONS: With the sustained decrease of alveolar bone height (less than 6 mm), orthodontic force value should be reduced according to the degree of periodontal bone loss. When the alveolar bone loss reduces to more than 6 mm and the root furcation exposes completely, orthodontic force value should be reduced significantly. Supported by Natural Science Foundation of Jiangxi Province (0540091).

Wang H; Wu JY; Zhou Q; Liu J

2013-06-01

184

Volumetric measurement of root resorption following molar mini-screw implant intrusion using cone beam computed tomography.  

UK PubMed Central (United Kingdom)

OBJECTIVE: Molar intrusion by mini-screw implantation can cause different degrees of root resorption. However, most methods (2-D and 3-D) used for evaluating root resorption have focused on the root length without considering 3-D resorption. The purpose of this study was to volumetrically evaluate root resorption using cone beam computed tomography(CBCT) after mini-screw implant intrusion. MATERIALS AND METHODS: 1. The volumes of 32 teeth were measured using CBCT and laser scanning to verify the accuracy of CBCT. 2. Twelve overerupted molars from adult patients were investigated in this study. After mini-screw implants were inserted into the buccal and palatal alveolar bones, 150 g of force was applied to the mini-screw implants on each side to intrude the molars. CBCT images of all patients were taken immediately prior to intrusion and after intrusion. The volumes of the roots were calculated using the Mimics software program. The differences between the pre-intrusion and post-intrusion root volumes were statistically evaluated with a paired-samples t-test. In addition, the losses of the roots were statistically compared with each other using one-way analysis of variance at the P<0.05 level. RESULTS: No statistically significant volume differences were observed between the physical (laser scanning) and CBCT measurements (P>0.05). The overerupted molars were significantly intruded (P<0.05), and the average intrusion was 3.30±1.60 mm. The differences between the pre-intrusion and post-intrusion root volumes were statistically significant for all of the roots investigated (P<0.05). The roots were sorted by volume loss in descending order as follows: mesiobuccal, palatal, and distobuccal. Statistical significance was achieved among the three roots. The average total resorption for each tooth was 58.39±1.54 mm(3). CONCLUSION: Volume measurement using CBCT was able to effectively evaluate root resorption caused by mini-screw intrusion. The highest volume loss was observed in the mesiobuccal root among the three roots of the investigated first molar teeth.

Li W; Chen F; Zhang F; Ding W; Ye Q; Shi J; Fu B

2013-01-01

185

Anti-resorptive agents reduce the size of resorption cavities: A three-dimensional dynamic bone histomorphometry study.  

UK PubMed Central (United Kingdom)

Alterations in resorption cavities and bone remodeling events during anti-resorptive treatment are believed to contribute to reductions in fracture risk. Here, we examine changes in the size of individual remodeling events associated with treatment with a selective estrogen receptor modulator (raloxifene) or a bisphosphonate (risedronate). Adult female rats (6months of age) were submitted to ovariectomy (n=17) or sham surgery (SHAM, n=5). One month after surgery, the ovariectomized animals were separated into three groups: untreated (OVX, n=5), raloxifene treated (OVX+Ral, n=6) and risedronate treated (OVX+Ris, n=6). At 10months of age, the lumbar vertebrae were submitted to three-dimensional dynamic bone histomorphometry to examine the size (depth, breadth and volume) of individual resorption cavities and formation events. Maximum resorption cavity depth did not differ between the SHAM (23.66±1.87?m, mean±SD) and OVX (22.88±3.69?m) groups but was smaller in the OVX+Ral (14.96±2.30?m) and OVX+Ris (14.94±2.70?m) groups (p<0.01). Anti-resorptive treatment was associated with reductions in the surface area of resorption cavities and the volume occupied by each resorption cavity (p<0.01 each). The surface area and volume of individual formation events (double-labeled events) in the OVX+Ris group were reduced as compared to other groups (p<0.02). Raloxifene treated animals showed similar amounts of bone remodeling (ES/BS and dLS/BS) compared to sham-operated controls but smaller cavity size (depth, breadth and volume). The current study shows that anti-resorptive agents influence the size of resorption cavities and individual remodeling events and that the effect of anti-resorptives on individual remodeling events may not always be directly related to the degree of suppression of bone remodeling.

Matheny JB; Slyfield CR; Tkachenko EV; Lin I; Ehlert KM; Tomlinson RE; Wilson DL; Hernandez CJ

2013-11-01

186

Anti-resorptive agents reduce the size of resorption cavities: A three-dimensional dynamic bone histomorphometry study.  

Science.gov (United States)

Alterations in resorption cavities and bone remodeling events during anti-resorptive treatment are believed to contribute to reductions in fracture risk. Here, we examine changes in the size of individual remodeling events associated with treatment with a selective estrogen receptor modulator (raloxifene) or a bisphosphonate (risedronate). Adult female rats (6months of age) were submitted to ovariectomy (n=17) or sham surgery (SHAM, n=5). One month after surgery, the ovariectomized animals were separated into three groups: untreated (OVX, n=5), raloxifene treated (OVX+Ral, n=6) and risedronate treated (OVX+Ris, n=6). At 10months of age, the lumbar vertebrae were submitted to three-dimensional dynamic bone histomorphometry to examine the size (depth, breadth and volume) of individual resorption cavities and formation events. Maximum resorption cavity depth did not differ between the SHAM (23.66±1.87?m, mean±SD) and OVX (22.88±3.69?m) groups but was smaller in the OVX+Ral (14.96±2.30?m) and OVX+Ris (14.94±2.70?m) groups (p<0.01). Anti-resorptive treatment was associated with reductions in the surface area of resorption cavities and the volume occupied by each resorption cavity (p<0.01 each). The surface area and volume of individual formation events (double-labeled events) in the OVX+Ris group were reduced as compared to other groups (p<0.02). Raloxifene treated animals showed similar amounts of bone remodeling (ES/BS and dLS/BS) compared to sham-operated controls but smaller cavity size (depth, breadth and volume). The current study shows that anti-resorptive agents influence the size of resorption cavities and individual remodeling events and that the effect of anti-resorptives on individual remodeling events may not always be directly related to the degree of suppression of bone remodeling. PMID:23988275

Matheny, J B; Slyfield, C R; Tkachenko, E V; Lin, I; Ehlert, K M; Tomlinson, R E; Wilson, D L; Hernandez, C J

2013-08-26

187

METASTATIC ANGIOSARCOMA PRESENTING AS DIFFUSE ALVEOLAR HEMORRHAGE  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Angiosarcoma is a rare malignant neoplasm of the vascular or lymphatic endothelium. Diffuse alveolar hemorrhage is a rare presenting manifestation of angiosarcoma. We describe a case of pulmonary metastasis of angiosarcoma who presented with diffuse alveolar hemorrhage as initial manifestation.

Rai, SP; Barthwal, MS; Bhattacharya, P; Bhargava, S; Pethe, M

188

Root resorption in relation to orthodontic tooth movement.  

UK PubMed Central (United Kingdom)

Root resorption is an undesirable sequela of orthodontic tooth movement. The odontoclasts are responsible for root resorption and the process of hyalinization is known to preceed the orthodontic root resorption. It is found that there are several predisposing factors, therefore an evaluation of these factors should be done by careful examination of personal medical history, severity of malocclusion and dental treatment (if any due to previous history of trauma), anterior crossbite etc. The evaluation becomes an essential factor as it helps the orthodontists in detecting the occurance and severity of the root resorption and thereby plan out the treatment more effectively. Orthodontic tooth movements especially intrusion and other movements like tipping, torque are all known to influence the root resorption, therefore the detection using radiographs and repair of root resorption is of utmost significance as root resorption is a more serious problem from a medicolegal stand point of view. However some studies have shown that the repair process is known to occur after the cessation of orthodontic treatment by the deposition of cementum of cellular type. In the light of orthodontist's liability of what is basically an unpredictable phenomenon, it is necessary that the speciality define this uncertainity and protect its members against unnecessary and unjustified litigation.

Ramanathan C; Hofman Z

2006-01-01

189

Root resorption in relation to orthodontic tooth movement.  

Science.gov (United States)

Root resorption is an undesirable sequela of orthodontic tooth movement. The odontoclasts are responsible for root resorption and the process of hyalinization is known to preceed the orthodontic root resorption. It is found that there are several predisposing factors, therefore an evaluation of these factors should be done by careful examination of personal medical history, severity of malocclusion and dental treatment (if any due to previous history of trauma), anterior crossbite etc. The evaluation becomes an essential factor as it helps the orthodontists in detecting the occurance and severity of the root resorption and thereby plan out the treatment more effectively. Orthodontic tooth movements especially intrusion and other movements like tipping, torque are all known to influence the root resorption, therefore the detection using radiographs and repair of root resorption is of utmost significance as root resorption is a more serious problem from a medicolegal stand point of view. However some studies have shown that the repair process is known to occur after the cessation of orthodontic treatment by the deposition of cementum of cellular type. In the light of orthodontist's liability of what is basically an unpredictable phenomenon, it is necessary that the speciality define this uncertainity and protect its members against unnecessary and unjustified litigation. PMID:16956115

Ramanathan, Chaitra; Hofman, Zden?k

2006-01-01

190

Bone resorption around pedicle screws after pedicle screw plate fixation  

Energy Technology Data Exchange (ETDEWEB)

To determine the frequency, level, distribution, onset, and pattern of progression of bone resorption that occurring around pedicle screws after pedicle screw plate fixation. Bone resorption around 902 pedicle screws was analyzed in post-operative, and follow-up radiographs obtained from 156 patients who underwent pedicle screw plate fixation. To determine the resorption degree, categorized arbitrarily as grade 1 (less than 1 mm), grade 2 (1mm or more, but less than 2 mm), or grade 3 (2mm or more), the width of radiolucent zones was measured. In 39 patients in whom resorption was graded 1, 2 or 3, the pattern of progression of 78 screws was evaluated. Resorption occurred around 78 (8.6%) screws in 39 (25%) patients, 26 of whom had more than on lesion. For 99% of screws, there was evidance of resorption within 12 weeks of pedicle screw plate fixation. During follow-up, 61.5% of screws (48/78) remained stable, while 38.5% (30 screws) showed progression to higher grades. The possibility of progression to a higher grade is less when the initial grade is lower. An understanding of the radiographic patterns of bone resorption is useful for monitoring a patient after pedicle screw plate fixation.

Park, Sun Won; Lee, Joo Hyuk; Seong, Su Ok; Park, Joo Tae [Cheongju St. Mary' s Hospital, Koyang (Korea, Republic of); Ehara, Shigeru [Iwate Medical University School of Medicine, Morioka (Japan)

2003-04-01

191

Bone resorption around pedicle screws after pedicle screw plate fixation  

International Nuclear Information System (INIS)

[en] To determine the frequency, level, distribution, onset, and pattern of progression of bone resorption that occurring around pedicle screws after pedicle screw plate fixation. Bone resorption around 902 pedicle screws was analyzed in post-operative, and follow-up radiographs obtained from 156 patients who underwent pedicle screw plate fixation. To determine the resorption degree, categorized arbitrarily as grade 1 (less than 1 mm), grade 2 (1mm or more, but less than 2 mm), or grade 3 (2mm or more), the width of radiolucent zones was measured. In 39 patients in whom resorption was graded 1, 2 or 3, the pattern of progression of 78 screws was evaluated. Resorption occurred around 78 (8.6%) screws in 39 (25%) patients, 26 of whom had more than on lesion. For 99% of screws, there was evidance of resorption within 12 weeks of pedicle screw plate fixation. During follow-up, 61.5% of screws (48/78) remained stable, while 38.5% (30 screws) showed progression to higher grades. The possibility of progression to a higher grade is less when the initial grade is lower. An understanding of the radiographic patterns of bone resorption is useful for monitoring a patient after pedicle screw plate fixation

2003-01-01

192

Pulmonary alveolar microlithiasis with calcified pleural plaques  

Directory of Open Access Journals (Sweden)

Full Text Available Pulmonary alveolar microlithiasis (PAM) is a rare disease. Herein we report a case of pulmonary alveolar microlithiasis who was suspected to have the disease on chest X-ray and was confirmed on high resolution CT and transbronchial lung biopsy. These investigations showed characteristic features of pulmonary alveolar microlithiasis with diffuse interstitial pulmonary fibrosis.

Malhotra Balbir; Sabharwal Raghu; Singh Mandeep; Singh Amarjeet

2010-01-01

193

Solanum malacoxylon toxicity: inhibition of bone resorption.  

UK PubMed Central (United Kingdom)

Young rabbits on high (0.57%) or low (0.24%) calcium were given an aqueous extract of Solanum malacoxylon (S.m.) leaves (20 g dried leaves/200 ml distilled water) intragastrically at 0, 12 and 36 hours. On bothe diets S.m. induced progressive hypophosphatasemia but serum calcium and phosphorus underwent only minor changes. In rabbits necropsied at 0, 12, 36, 60, 84 and 108 hours, S.m. was shown to have a negative effect on the resorbing osteocytes. With retarded osteocytic osteolysis, osteopetrosis resulted. Further regressive changes in the osteocytes resulted in osteonecrosis which was observed within 12 hours after administration of S.m. extract. The osteonecrosis, combined with retarded apposition, later resulted in osteopenia. It was concluded that the recommended dietary calcium for growing rabbits--about 0.6%--is too high. Whereas the histologic appearance of bone in rabbits fed low calcium was normal, bones from rabbits on high calcium showed retarded resorption and the rabbits had a relative hypophosphatasemia.

Santos MN; Nunes VA; Nunes IJ; Barros SS; Wasserman RH; Krook L

1976-10-01

194

Solanum malacoxylon toxicity: inhibition of bone resorption.  

Science.gov (United States)

Young rabbits on high (0.57%) or low (0.24%) calcium were given an aqueous extract of Solanum malacoxylon (S.m.) leaves (20 g dried leaves/200 ml distilled water) intragastrically at 0, 12 and 36 hours. On bothe diets S.m. induced progressive hypophosphatasemia but serum calcium and phosphorus underwent only minor changes. In rabbits necropsied at 0, 12, 36, 60, 84 and 108 hours, S.m. was shown to have a negative effect on the resorbing osteocytes. With retarded osteocytic osteolysis, osteopetrosis resulted. Further regressive changes in the osteocytes resulted in osteonecrosis which was observed within 12 hours after administration of S.m. extract. The osteonecrosis, combined with retarded apposition, later resulted in osteopenia. It was concluded that the recommended dietary calcium for growing rabbits--about 0.6%--is too high. Whereas the histologic appearance of bone in rabbits fed low calcium was normal, bones from rabbits on high calcium showed retarded resorption and the rabbits had a relative hypophosphatasemia. PMID:185004

Santos, M N; Nunes, V A; Nunes, I J; Barros, S S; Wasserman, R H; Krook, L

1976-10-01

195

[Alveolar rhabdomyosarcoma of the skin  

UK PubMed Central (United Kingdom)

The authors present the case of an 18 years old male patient with a tumor localized in the skin of the nose, which had a fast evolution provoking in a month regional metastases. Histologically it proved to be an alveolar rhabdomyosarcoma. The clinical and histopathological characters are described, and considerations about the origin of this tumor are made.

Deneo H; Carlevaro A; Espasandín J; Carzoglio JC; Cendán ME; Vignale RA

1983-01-01

196

Human alveolar echinococcosis in Kyrgyzstan.  

UK PubMed Central (United Kingdom)

Human echinococcosis is a reportable disease in Kyrgyzstan. Between 1995 and 2011, human alveolar echinococcosis increased from <3 cases per year to >60 cases per year. The origins of this epidemic, which started in 2004, may be linked to the socioeconomic changes that followed the dissolution of the former Soviet Union.

Usubalieva J; Minbaeva G; Ziadinov I; Deplazes P; Torgerson PR

2013-07-01

197

Injectable alveolar bone repairing material  

UK PubMed Central (United Kingdom)

The invention relates to an injectable alveolar bone repairing material. A tridimensional network structure is formed by Beta-tertiary calcium phosphate gains by taking polyphosphate ester as a bonding agent and comprises holes which are communicated mutually, wherein the holes internally contain tetracycline the mass ratio of the polyphosphate ester to Beta-tertiary calcium phosphate is 1: (3-10) and the mass ratio of the tetracycline to the Beta-tertiary calcium phosphate is (0.001-0.1):1. A method for preparing the injectable alveolar bone repairing material comprises the following concrete steps: preparing a sizing agent with low viscosity by unsaturated polyphosphate ester, a liquid cross-linking agent, a pore creating material, the Beta-tertiary calcium phosphate and the tetracycline adding an evocating agent into the sizing agent making copolyreaction between the unsaturated polyphosphate ester and the liquid cross-linking agent under the action of the evocating agent so that the viscosity of the sizing agent is gradually increased before solidification, injecting the sizing agent into a die cavity at the defect part of an alveolar bone so that the sizing agent is solidified and formed in the die cavity. The alveolar bone repairing material has the advantages of tetracycline slowly-releasing, degradation, injection and little side effect, thereby effectively playing the roles of curing the periodontal disease and preventing the inflammation after an operation.

JIANZHONG XIAO; FENG XIA; CHENGMEI LIU; JING MAO; JINJUN QIU; YAN LI; TAO FU; ZHIXING ZHANG

198

Root resorptions in a patient with hemifacial atrophy.  

UK PubMed Central (United Kingdom)

Hemifacial atrophy (Parry-Romberg syndrome) is a rare but well-recognized condition. The developmental effects on facial and oral structures have been well documented in the literature. However, the etiology of hemifacial atrophy remains unknown. Previous reported alterations in tooth growth and development include delayed tooth eruption, abnormal root morphology, and malocclusion but not root resorption. This report presents the orofacial changes from hemifacial atrophy in a 22-yr-old woman and describes the occurrence of root resorptions in two regions affected by this condition. The concurrent presence of root resorptions in both the maxilla and mandible in the regions showing the most severe dental malformations points to root resorption as an additional complication of hemifacial atrophy.

Fayad S; Steffensen B

1994-06-01

199

Multiple Idiopathic Apical Root Resorption: a Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available The aim of this case report was to present a case of multiple idiopathic apical root resorption which is a rare condition in a 17-year-old adult male. External root resorption of the permanent teeth is a multifactorial process. Well-recognized causes of apical rootresorption in permanent teeth include orthodontic therapy, trauma, periapical or periodontal inflammation, tumors, cysts, occlusal stress, impacted teeth, systemic conditions, endocrine imbalances and dietary habits. When none of these causes are present, it is termed idiopathic root resorption which may be either cervical or apical.Multiple idiopathic apical root resorption is a rare condition which is usually detected as an incidental radiographic finding. However, it may cause pain and mobility in severe cases.

L. Khojastepour; P. Bronoosh; M. Azar

2010-01-01

200

Growth factor-mediated vertical mandibular ridge augmentation: a case report.  

UK PubMed Central (United Kingdom)

Posterior vertical alveolar ridge deficiencies are challenging defects to treat predictably and often require autogenous bone-harvesting procedures. Traditional treatment modalities, eg, guided bone regeneration, distraction osteogenesis, and autogenous grafts, present with a number of potential complications and limited success when used to restore vertical ridge height. Recent advances in recombinant growth factor technology may provide viable, alternative therapies for the treatment of significant alveolar ridge deficiencies. This proof-of-principle case report examines the utility and effectiveness of using a composite graft of freeze-dried bone allograft and recombinant human platelet-derived growth factor BB in conjunction with an overlying titanium mesh to regenerate well-vascularized bone in a significant posterior mandibular ridge defect prior to implant placement. The important role of the overlying periosteum as a possible key source of osteogenic cells during growth factor-enhanced regenerative procedures is emphasized.

Guze KA; Arguello E; Kim D; Nevins M; Karimbux NY

2013-09-01

 
 
 
 
201

Evaluation of Bone Volume After Secondary Bone Grafting in Unilateral Alveolar Cleft Using Computer-Aided Engineering.  

UK PubMed Central (United Kingdom)

The purpose of this study was to evaluate the initial defect and the outcome of bone grafts for unilateral alveolar cleft. To determine the absorption of the bone graft in patients with unilateral cleft, computer-aided engineering (CAE) with multi-detector row computed tomography (MDCT) was used. MDCT scans of 29 patients were taken immediately preoperatively and at 1 month and 6 months postoperatively. The patients underwent bone grafting between 8 and 14 years of age using iliac crest bone grafts. Three-dimensional models were created in each period, and the defect at the alveolar cleft and volume of the bone graft were determined in each patient using CAE. Cleft volume and success of alveolar bone grafting were significantly correlated (P < .01). Alveolar clefts with cleft palate required more bone volume than those without cleft palate (P < .01), but the resorption rate did not significantly differ between alveolar clefts with and without cleft palate (0.48 ± 0.14 and 0.49 ± 0.18, respectively; P = .93). In conclusion, three-dimensional reconstruction of bone grafts using CAE based on MDCT provides a valuable objective assessment of graft volume.

Nagashima H; Sakamoto Y; Ogata H; Miyamoto J; Yazawa M; Kishi K

2013-09-01

202

Open bite as a risk factor for orthodontic root resorption.  

Science.gov (United States)

The purpose of the present study was to clarify the prevalence and degree of root resorption induced by orthodontic treatment in patients with and without open bite. One hundred and eleven patients treated with multibracket appliances were retrospectively selected from the patients and divided into non-open bite (NOB) and open bite (OB) groups. The severity of root resorption and the root shape were classified into five groups on periapical radiographs before and after treatment. Moreover, only in the OB group, all teeth were sub-divided into functional and hypofunctional ones that are occluding and non-occluding.As the results of multiple linear regression analysis of patient characteristics and clinical variables with the number of overall root resorption, the independent variables that were found to contribute significantly to root resorption were bite and abnormal root shape. The prevalences of root resorption evaluated in the number of patients were significantly higher in OB group than in NOB group, and those in the number of teeth were significantly higher in OB group than in NOB group, in particular anterior and premolar teeth. The prevalence of resorbed teeth with abnormal root shapes was also significantly higher in OB group than in NOB group. On the other hand, in OB group, the prevalences of root resorption and teeth with abnormal root shape were significantly greater in hypofunctional teeth than in normal functional teeth.There are more teeth with root resorption and abnormal root shape in open bite cases than in normal bite cases, and more teeth with abnormal root shapes and root resorption in hypofunctional teeth than in functional teeth. PMID:23307804

Motokawa, Masahide; Terao, Akiko; Kaku, Masato; Kawata, Toshitsugu; Gonzales, Carmen; Darendeliler, M Ali; Tanne, Kazuo

2013-01-01

203

Open bite as a risk factor for orthodontic root resorption.  

UK PubMed Central (United Kingdom)

The purpose of the present study was to clarify the prevalence and degree of root resorption induced by orthodontic treatment in patients with and without open bite. One hundred and eleven patients treated with multibracket appliances were retrospectively selected from the patients and divided into non-open bite (NOB) and open bite (OB) groups. The severity of root resorption and the root shape were classified into five groups on periapical radiographs before and after treatment. Moreover, only in the OB group, all teeth were sub-divided into functional and hypofunctional ones that are occluding and non-occluding.As the results of multiple linear regression analysis of patient characteristics and clinical variables with the number of overall root resorption, the independent variables that were found to contribute significantly to root resorption were bite and abnormal root shape. The prevalences of root resorption evaluated in the number of patients were significantly higher in OB group than in NOB group, and those in the number of teeth were significantly higher in OB group than in NOB group, in particular anterior and premolar teeth. The prevalence of resorbed teeth with abnormal root shapes was also significantly higher in OB group than in NOB group. On the other hand, in OB group, the prevalences of root resorption and teeth with abnormal root shape were significantly greater in hypofunctional teeth than in normal functional teeth.There are more teeth with root resorption and abnormal root shape in open bite cases than in normal bite cases, and more teeth with abnormal root shapes and root resorption in hypofunctional teeth than in functional teeth.

Motokawa M; Terao A; Kaku M; Kawata T; Gonzales C; Darendeliler MA; Tanne K

2013-01-01

204

Isolation of alveolar plates from Coleps hirtus.  

UK PubMed Central (United Kingdom)

In the ciliate Coleps hirtus, the alveoli contain rigid alveolar plates that are almost unstudied so far. Neither the exact composition nor the genesis and function are known. A necessary step to study the alveolar plates is to isolate these structures in an adequate amount. Therefore, culture conditions of C. hirtus were optimized to obtain an axenic and dense long-time culture. The protocol we developed to isolate C. hirtus alveolar plates is presented and clean alveolar plates were documented via scanning electron microscopy. The described procedure delivers alveolar plates of very good structure and integrity with preserved filigree details in sufficient amount. They can be analysed via a range of different material and biological characterisations. Since there are indications of a mineral phase within the alveolar plates, the presented results will allow to study C. hirtus alveolar plates also in the context of biomineralisation.

Lemloh ML; Hoos S; Görtz HD; Brümmer F

2013-01-01

205

Biomechanical aspect of feline dental resorptive lesions formation  

Directory of Open Access Journals (Sweden)

Full Text Available Feline dental resorptive lesions affect more than one third of all adult domestic cats and continue to be an enigma in the veterinary dental science although different theories about the pathogenesis of these lesions have been proposed. Recently, a hypothesis was introduced that local mechanical trauma could be an important factor in the initiation of feline dental resorptive lesions and that there is a correlation between the occurrence of resorptive lesions and occlusal trauma in cats. The aim of this study was to analyse stress distribution in feline tooth during occlusal loading in order to accept or reject the hypothesis that dental resorptive lesions in cats might be caused by occlusal trauma. A solid model of feline tooth had to be created in order to perform the investigation. The idea was to gain data for tooth displacement (deformation) and stress and strain distribution under loading generally for any feline tooth using the finite element method. The results of the study contribute to the theory that occlusal overload might be one of the causes in multifactorial resorptive lesions in cats. Succession of tensile and compressive stresses and tooth displacement during occlusal loading might be a contributive factor in the pathogenesis of feline resorptive lesions. However, further research is required to confirm this statement.

Živkovi? R.; Mili?-Lemi? Aleksandra; Tiha?ek-Šoji? Ljiljana; Ili? J.

2010-01-01

206

Inflammatory root resorption in primary molars: prevalence and associated factors.  

UK PubMed Central (United Kingdom)

This study aimed at determining the prevalence of inflammatory root resorption and associated factors in 1068 primary mandibular molars in 453 children 3 to 12 years of age. Age, dental history and medical history were recorded using a questionnaire administered to the children's parents/caregivers. Previously trained and calibrated examiners assessed radiographic images of the primary molars by direct observation, with the aid of a viewing box. Root resorption (physiological or inflammatory), dental crown status (healthy, carious with no pulp involvement, carious with pulp involvement and evidence of restoration), and pulpotomy or pulpectomy were determined. Data analysis involved descriptive statistics, the chi-square test and a multiple logistic regression (p < 0.05). The prevalence of inflammatory root resorption was 16.2% (n = 173). The male gender (OR: 1.4; 95% CI), the 3-to-7-years age bracket (OR: 1.5; 95% CI), an unhealthy dental crown (OR: 8.7; 95% CI), caries with pulp involvement (OR: 7.4; 95% CI), pulpotomy (OR: 3.1; 95% CI), and pulpectomy (OR: 5.4; 95% CI) were risk factors for the occurrence of inflammatory root resorption in primary molars. In conclusion, the prevalence of inflammatory root resorption in the present sample was 16.2%. Gender, age, an unhealthy tooth, caries with pulp involvement, pulpotomy, pulpectomy, and the absence of a restoration were associated with a higher occurrence of inflammatory root resorption in primary molars.

Vieira-Andrade RG; Drumond CL; Alves LP; Marques LS; Ramos-Jorge ML

2012-07-01

207

Distracción osteogénica alveolar por medio de dispositivos yuxtaoseos: Revisión de literatura y reporte de caso  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Resumo: A reconstrução dos rebordos alveolares atroficos por meio da técnica de distração osteogênica alveolar (DOA) oferece um resultado previsível com baixas taxas de morbilidade e uma ganância notável de tecido ósseo e tecidos moles, em comparação com as técnicas tradicionalmente utilizadas. Foi atendido um paciente masculino de 21 anos de idade o qual apressentaba afrofia severa do rebordo alveolar na região anterior da maxila por meio de DOA, utilizando (more) um dispositivo yuxtaoseo (Conexão Implant System® - SP-Brasil), começando a ativação do aparelho aos 7 dias após a instalação, com uma padronização de 1mm diários ate lograr os comprimentos ósseos desejado, retirando-se o distrator e colocando-se os implantes osseointegrados às 10 semanas posteriores. Pudo-se comprovar clinica e radiográficamente o incremento em comprimento e volume ósseo necessário para a reabilitação com implantes Abstract in spanish La reconstrucción de rebordes alveolares atróficos por medio de la técnica de distracción osteogénica alveolar (DOA) ofrece un resultado previsible con bajas tasas de morbilidad y una ganancia notable de tejido óseo y tejidos blandos, en comparación con las técnicas tradicionalmente utilizadas. Fue atendido un paciente masculino de 21 años de edad quien presentaba atrofia severa del reborde alveolar en región anterior del maxilar por medio de DOA, utilizando un (more) dispositivo yuxtaoseo (Conexão Implant System® - SP-Brasil). Comenzando la activación del dispositivo a los 7 días posteriores a la instalación, con un patrón de activación de 1 mm. diarios hasta alcanzar la altura ósea deseada, retirándose el distractor y colocando los implantes oseointegrados a las 10 semanas posteriores, pudo comprobarse clínica y radiográficamente el incremento en altura y volumen óseo necesario para la rehabilitación por medio de implantes Abstract in english Abstract: The reconstruction of atrophic alveolar ridges by means of the technique of alveolar distraction osteogenesis (ADO) offers a foregone result with small morbidity rates and a remarkable gain of bony and soft tissues, in comparison with the traditionally used techniques. A masculine patient of 21 years old who presented a severe atrophy of alveolar ridge in the region anterior of the maxillary was assisted by means of ADO, using a juxtaosseous device (Connection I (more) mplant System® - SP-Brazil), beginning the activation from the device to the 7 days later to the installation, with a pattern of activation 1 mm. per day until reaching the wanted bony height, being carried out the retirement of the distractor and the placement of the implants 10 weeks later. It could be proven clinic and radiographic the gain of the height and necessary bony volume for the rehabilitation by implants

Maurette, Paul E; de Maurette, Marvis Allais; Mazzonetto, Msc, PhD, Renato

2005-01-01

208

Autogenous calvarium bone grafting as a treatment for severe bone resorption in the upper maxilla: a case report.  

Science.gov (United States)

Atrophic maxilla rehabilitation has been the subject of several studies for decades; despite this, there are still many different therapeutic choices for the best way to treat maxillary resorption in order to enable implant placement and integration. These possibilities include the optimal use of remaining bone structures, such as the pterygoid processes or zygomatic arch, which involves using zygomaticus and pterygoid implants in combination with standard implants placed in the residual bone; alternatively, regenerative techniques, alveolar bone expansion/distraction or bone grafting techniques may be used. Severe maxillary atrophy has a multifactorial aetiology; the most important factors being long evolution edentulism, hyperpneumatization of the maxillary sinus, post-traumatic deficit, bone loss after surgery (tumours, cysts) and periodontal problems or infection. In this report, we present a clinical case of onlay block reconstruction in an atrophic maxilla with harvested cranial calvarium bone grafts for successful future implant-supported oral rehabilitation. PMID:19767715

Díaz-Romeral-Bautista, Migugel; Manchón-Miralles, Angel; Asenjo-Cabezón, Jorge; Cebrián-Carretero, José-Luis; Torres-García-Denche, Jesús; Linares-García-Valdecasas, Rafael

2010-03-01

209

Triiodo-L-thyronine rapidly stimulates alveolar fluid clearance in normal and hyperoxia-injured lungs.  

UK PubMed Central (United Kingdom)

RATIONALE: Edema fluid resorption is critical for gas exchange and requires active epithelial ion transport by Na, K-ATPase and other ion transport proteins. OBJECTIVES: In this study, we sought to determine if alveolar fluid clearance (AFC) is stimulated by 3,3',5 triiodo-L-thyronine (T(3)). METHODS: AFC was measured in in situ ventilated lungs and ex vivo isolated lungs by instilling isosmolar 5% bovine serum albumin solution with fluorescein-labeled albumin tracer and measuring the change in fluorescein isothiocyanate-albumin concentration over time. MEASUREMENTS AND MAIN RESULTS: Systemic treatment with intraperitoneal injections of T(3) for 3 consecutive days increased AFC by 52.7% compared with phosphate-buffered saline-injected control rats. Membranes prepared from alveolar epithelial cells from T(3)-treated rats had higher Na, K-ATPase hydrolytic activity. T(3) (10(-6) M), but not reverse T(3) (3,3',5' triiodo-L-thyronine), applied to the alveolar space increased AFC by 31.8% within 1.5 hours. A 61.5% increase in AFC also occurred by airspace instillation of T(3) in ex vivo isolated lungs, suggesting a direct effect of T(3) on the alveolar epithelium. Exposure of rats to an oxygen concentration of greater than 95% for 60 hours increased wet-to-dry lung weights and decreased AFC, whereas the expression of thyroid receptor was not markedly changed. Airspace T(3) rapidly restored the AFC in rat lungs with hyperoxia-induced lung injury. CONCLUSIONS: Airspace T(3) rapidly stimulates AFC by direct effects on the alveolar epithelium in rat lungs with and without lung injury.

Bhargava M; Runyon MR; Smirnov D; Lei J; Groppoli TJ; Mariash CN; Wangensteen OD; Ingbar DH

2008-09-01

210

Alveolar permeability and liquid absorption during partial liquid ventilation of rats with perflubron.  

UK PubMed Central (United Kingdom)

We examined the effect of instilled perflubron (LiquiVent) on the transport properties of alveolar epithelium in anesthetized rats. Krebs-Ringer bicarbonate (1 to 4 ml) containing (125)I-albumin, [(3)H]mannitol and [(14)C] sucrose was instilled into airspaces either alone (n = 29), or with 1 (n = 21) or 2 (n = 12) ml perflubron and sampled 30 min later. Absorption was deduced from the changes in (125)I-albumin activity per unit volume in the airspace instillate, and changes in [(3)H]mannitol and [(14)C]sucrose activity per unit volume were used to evaluate the passive permeability of the alveolar-airway barrier. The rate of Ringer absorption depended on the volume instilled [0.38 (ml/h)/ml Ringer]. Perflubron (1 or 2 ml) increased Ringer absorption by 0.26 (p < 0. 001) and 0.19 ml/h (p < 0.05), respectively. However, 2 ml perflubron increased absorption less than did the same additional volume of Ringer (p < 0.001). The passive permeability of the alveolar-airway barrier increased exponentially with instilled Ringer volume. Sucrose/mannitol size selectivity was lost when Ringer volume was > 2 ml and albumin leaked from airspaces when it was 4 ml. Instillation of 2 ml perflubron prevented this increase in permeability, but 1 ml did not. No albumin leaked with perflubron even when the total volume of liquid in airspaces (Ringer + perflubron) was > 4 ml. These results suggest that perflubron can be beneficial in pulmonary edema by redistributing the alveolar liquid over a larger surface area, thus accelerating resorption. In addition, larger doses of perflubron may better preserve epithelial permeability during alveolar flooding.

Ricard JD; Martin-Lefèvre L; Dreyfuss D; Saumon G

2000-01-01

211

The Macquarie Ridge Complex.  

Science.gov (United States)

The north-east-south-west trending Macquarie Ridge-Trench complex and its intersection with the Indian-Pacific-Antarctic Ridge provides a unique morphological connection between New Zealand and Antarctica. The seismically active Macquarie complex has been...

D. E. Hayes M. Talwani D. A. Christoffel

1972-01-01

212

The repair of orthodontic root resorption: an ultrastructural study.  

UK PubMed Central (United Kingdom)

It has previously been shown by light (LM) and scanning electron microscopy (SEM), that after force is terminated, repair of the orthodontic root resorption lacunae occur by deposition of new cementum. The ultrastructural details of the process are not well established. Since it has been hypothesized that a new barrier to protect the root surface is formed during the reparative phase, new information on this aspect of orthodontic root resorption may be valuable. The aim of the present investigation was, by using transmission electron microscopy (TEM), to study in more detail the repair of orthodontic root resorption lacunae and the re-establishment of the adjacent periodontal membrane (PM). Three experimental tooth movement groups of rats (age 40-45 days) were used. The maxillary first molar was moved mesially by a closed coil spring for 10, 14, and 21 days. The results indicate that transition of active root resorption into a process of repair which occurs even in the presence of a light force, is associated with invasion of fibroblast-like cells from the circumference into the active root resorption site. After 10 days, formation of new tooth supporting structures was seen in the periphery of the resorption lacunae, while active resorption by multinucleated odontoclast-like cells (OD) took place in the central parts. In the later phases, after termination of force, the repair process is similar to the early cementogenesis occurring during tooth development. New mineralized cementum was observed on the resorbed root surface by 21 days. After deposition of the new cementum, the structures of a new periodontal ligament (PDL) were comparable with the control specimens.

Brudvik P; Rygh P

1995-06-01

213

The repair of orthodontic root resorption: an ultrastructural study.  

Science.gov (United States)

It has previously been shown by light (LM) and scanning electron microscopy (SEM), that after force is terminated, repair of the orthodontic root resorption lacunae occur by deposition of new cementum. The ultrastructural details of the process are not well established. Since it has been hypothesized that a new barrier to protect the root surface is formed during the reparative phase, new information on this aspect of orthodontic root resorption may be valuable. The aim of the present investigation was, by using transmission electron microscopy (TEM), to study in more detail the repair of orthodontic root resorption lacunae and the re-establishment of the adjacent periodontal membrane (PM). Three experimental tooth movement groups of rats (age 40-45 days) were used. The maxillary first molar was moved mesially by a closed coil spring for 10, 14, and 21 days. The results indicate that transition of active root resorption into a process of repair which occurs even in the presence of a light force, is associated with invasion of fibroblast-like cells from the circumference into the active root resorption site. After 10 days, formation of new tooth supporting structures was seen in the periphery of the resorption lacunae, while active resorption by multinucleated odontoclast-like cells (OD) took place in the central parts. In the later phases, after termination of force, the repair process is similar to the early cementogenesis occurring during tooth development. New mineralized cementum was observed on the resorbed root surface by 21 days. After deposition of the new cementum, the structures of a new periodontal ligament (PDL) were comparable with the control specimens. PMID:7621920

Brudvik, P; Rygh, P

1995-06-01

214

Two Ridges, One Explaination  

CERN Document Server

We attribute the phenomenon known as "the ridge" to long range initial state correlations from Color Glass Condensate flux tubes and later stage radial flow. We show that this description can explain the amplitude and azimuthal width of the soft ridge and nearly explain that of the hard ridge, suggesting that the two are essentially the same phenomenon.

Moschelli, George

2009-01-01

215

Effect of Nasal Floor Closure on the Size of Alveolar Cleft in Complete Unilateral or Bilateral Primary Cleft Palate  

Directory of Open Access Journals (Sweden)

Full Text Available Introduction: Cleft lip (CL) and cleft palate (CP) are among the most common congenital anomalies. Constituting 65% of head and neck anomalies in isolated or syndromic forms, they are considered as the most common head and neck congenital deformities in children. Methods: 15 children from the Tabriz Children Hospital were evaluated in this descriptive-analytic cross sectional study that possessed unilateral and bilateral cleft lip and palate with inclusion criteria. The effect of nasal floor reconstruction on the size of alveolar cleft and palatal anterior fistula formation were evaluated in primary unilateral and bilateral cleft palate. Results: There were 11 (73.3%) male and only 4 (26.7%) female patients in the sample group. The mean duration from first consult to reconstructive surgery was 3.4±1.8 months (1 to 9 months range). The width of alveolar cleft and alveolar ridge angle on cleft side compared to normal side in sagittal and coronal axis was significant after nasal floor reconstruction (P=0.001, P=0.02), while septal angle changes were not significant (P=0.26), which means no increase in septal deviation has been documented. Conclusion: Considering the significant changes of alveolar cleft width and alveolar ridge angle on cleft side compared to normal side in sagittal and coronal axis after nasal floor closure, this method can be applied as a new interventional surgery in primary unilateral and bilateral cleft palate.

SH Abdolahi Fakhim; B Mirzakochaki; E Massah; M Moghadaszadeh

2012-01-01

216

Osteoprotegerin influences the bone resorption activity of osteoclasts.  

Science.gov (United States)

The aim of the present study was to determine whether osteoprotegerin (OPG) influences the bone resorption activity of osteoclasts. RAW264.7 cells were induced by macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-?B ligand (RANKL) and 0, 10, 20, 50 and 100 ng/ml OPG were added into various groups in the presence of the two cytokines. The OPG treatment was continued for 24 h. Osteoclast differentiation and activation were estimated via TRAP staining assay, TRITC-conjugated phalloidin staining, resorption activity analysis. Furthermore, the expression levels of the osteoclastic bone resorption-related genes MMP-9, cathepsin K and carbonic anhydrase II (CA II) were examined using real-time polymerase chain reaction (PCR). The data demonstrated that high concentrations of OPG could inhibit the differentiation and activation of osteoclasts. Furthermore, real-time PCR analysis illustrated that OPG decreased the expression of MMP-9 and cathepsin K in different concentrations of OPG and it decreased the expression of CA II genes at 10 and 20 ng/ml concentrations of OPG. For the time gradient study, OPG decreased the expression of MMP-9 and CA II genes but not that of the cathepsin K gene. In summary, the resorption activity of osteoclasts was suppressed by high concentrations of OPG and, at the molecular level, OPG decreased the expression of osteoclastic bone resorption-related genes. PMID:23563320

Fu, Ying-Xiao; Gu, Jian-Hong; Zhang, Yi-Ran; Tong, Xi-Shuai; Zhao, Hong-Yan; Yuan, Yan; Liu, Xue-Zhong; Bian, Jian-Chun; Liu, Zong-Ping

2013-04-04

217

Osteoprotegerin influences the bone resorption activity of osteoclasts.  

UK PubMed Central (United Kingdom)

The aim of the present study was to determine whether osteoprotegerin (OPG) influences the bone resorption activity of osteoclasts. RAW264.7 cells were induced by macrophage colony-stimulating factor (M-CSF) + receptor activator of nuclear factor-?B ligand (RANKL) and 0, 10, 20, 50 and 100 ng/ml OPG were added into various groups in the presence of the two cytokines. The OPG treatment was continued for 24 h. Osteoclast differentiation and activation were estimated via TRAP staining assay, TRITC-conjugated phalloidin staining, resorption activity analysis. Furthermore, the expression levels of the osteoclastic bone resorption-related genes MMP-9, cathepsin K and carbonic anhydrase II (CA II) were examined using real-time polymerase chain reaction (PCR). The data demonstrated that high concentrations of OPG could inhibit the differentiation and activation of osteoclasts. Furthermore, real-time PCR analysis illustrated that OPG decreased the expression of MMP-9 and cathepsin K in different concentrations of OPG and it decreased the expression of CA II genes at 10 and 20 ng/ml concentrations of OPG. For the time gradient study, OPG decreased the expression of MMP-9 and CA II genes but not that of the cathepsin K gene. In summary, the resorption activity of osteoclasts was suppressed by high concentrations of OPG and, at the molecular level, OPG decreased the expression of osteoclastic bone resorption-related genes.

Fu YX; Gu JH; Zhang YR; Tong XS; Zhao HY; Yuan Y; Liu XZ; Bian JC; Liu ZP

2013-06-01

218

Alveolar septal pulmonary amyloidosis: a case report  

Energy Technology Data Exchange (ETDEWEB)

Primary pulmonary amyloidosis is a rare diesase, and is classified as either tracheobronchial or parenchymal; the latter is also divided into nodular and diffuse alveolar septal forms. The alveolar septal form is extremely rare and usually produces reticular and nodular opacities. We describe a case of alveolar septal pulmonary amyloidosis manifested as multiple small nodules on chest radiograph and disseminated micronodules mainly in centrilobular and subpleural location without reticular opacities, on HRCT.

Kim, Young Choon; Yi, Jeong Geun; Kim, Ho Chul; Bae, Sang Hoon [Hallym Univ. College of Medicine, Seoul (Korea, Republic of)

1997-06-01

219

Pulmonary alveolar septal calcinosis causing progressive respiratory failure in acute lymphoblastic leukemia in childhood.  

UK PubMed Central (United Kingdom)

A syndrome of pulmonary alveolar septal calcinosis, pneumothorax, and pneumomediastinum, leading to rapidly progressive acute respiratory insufficiency and death was observed in 2 children with acute lymphoblastic leukemia (ALL). Primary clinical and radiological considerations in these patients were pulmonary edema and infection, and the diagnosis of pulmonary alveolar septal calcification was established only at autopsy. One patient, a 15-year-old girl, was found also to have parathyroid hyperplasia typical of familial hyperparathyroidism. The other, a 16-month-old girl, showed osteitis fibrosa of the bones and parathyroid hyperplasia of secondary type, suggesting that the pulmonary calcinosis resulted from hypercalcemia caused by a parathormone or prostaglandin-secreting tumor. The cause of pneumothorax and pneumomediastinum may have been rupture of calcified alveolar septa induced by high PEEP during ventilation of these patients. Other possible mechanisms contributing to hypercalcemia and pulmonary calcinosis in children with acute leukemia include bone resorption due to marrow infiltration, immobilization syndrome, renal failure, and administration of calcium, phosphate, or bicarbonate. This complication of acute leukemia in childhood is rare (2 patients in 430 autopsied over the period 1961-1982 at Childrens Hospital of Los Angeles). How often the process can be reversed if diagnosed before severe respiratory insufficiency is present is not known.

Sinniah D; Landing BH; Siegel SE; Laug WE; Gwinn JL

1986-01-01

220

Pulmonary alveolar septal calcinosis causing progressive respiratory failure in acute lymphoblastic leukemia in childhood.  

Science.gov (United States)

A syndrome of pulmonary alveolar septal calcinosis, pneumothorax, and pneumomediastinum, leading to rapidly progressive acute respiratory insufficiency and death was observed in 2 children with acute lymphoblastic leukemia (ALL). Primary clinical and radiological considerations in these patients were pulmonary edema and infection, and the diagnosis of pulmonary alveolar septal calcification was established only at autopsy. One patient, a 15-year-old girl, was found also to have parathyroid hyperplasia typical of familial hyperparathyroidism. The other, a 16-month-old girl, showed osteitis fibrosa of the bones and parathyroid hyperplasia of secondary type, suggesting that the pulmonary calcinosis resulted from hypercalcemia caused by a parathormone or prostaglandin-secreting tumor. The cause of pneumothorax and pneumomediastinum may have been rupture of calcified alveolar septa induced by high PEEP during ventilation of these patients. Other possible mechanisms contributing to hypercalcemia and pulmonary calcinosis in children with acute leukemia include bone resorption due to marrow infiltration, immobilization syndrome, renal failure, and administration of calcium, phosphate, or bicarbonate. This complication of acute leukemia in childhood is rare (2 patients in 430 autopsied over the period 1961-1982 at Childrens Hospital of Los Angeles). How often the process can be reversed if diagnosed before severe respiratory insufficiency is present is not known. PMID:3473456

Sinniah, D; Landing, B H; Siegel, S E; Laug, W E; Gwinn, J L

1986-01-01

 
 
 
 
221

Production of interferon by alveolar macrophages.  

UK PubMed Central (United Kingdom)

Acton, Jean D. (Bowman Gray School of Medicine, Winston-Salem, N.C.), and Quentin N. Myrvik. Production of interferon by alveolar macrophages. J. Bacteriol. 91:2300-2304. 1966.-Rabbit alveolar macrophages inoculated with parainfluenza-3 virus in vitro produce a viral inhibitor which possesses the properties of interferon. The interferon is nondialyzable, is stable at pH 4, is not sedimented at 100,000 x g, exhibits species specificity, and can passively protect other alveolar macrophages from infection with virulent rabbitpox virus. The possible significance of alveolar macrophage-produced interferon is discussed.

Acton JD; Myrvik QN

1966-06-01

222

Peculiarities of the bone tissue resorption under microgravity conditions  

Science.gov (United States)

The actual problem - peculiarities of resorptive processes in the spongiose of thingbones - we studied with the use of tranmissive electron microscopy in experiments on rats (American space station SLS-2) and on monkeys Macaca mulatt? (BION-11). Animals were onboard during 2 weeks. There was established, that the resorption happen with osteoclasts participation. They can create groups of cells. In the osteoclasts population we indicated not typical for the control (ground experiment) "giant" cells, which have on ultrathin sections 5-6 nuclei, many lysosomes, well developed "light" zone and "brush-border". The destruction of minera lized matrix in bone lacunas also happens by the way of osteolytic activity of osteocytes. Lysosome ferments of osteocytes are secreted by the eczocytosis. The osteocytic osteolysis, as well as the osteoclastic one can be seen as a physiological, gormon-dependent mechanism of resorption. The presence of a considerable number of neutrophiles, which enter in some zones of resorption is also typical. When these neutrophiles destruct, they release lysosomic ferments that dissolve the bone matrix. In some zones of resorption we noted the presence of the row from collagen fibrils, which loosed crystals , on mineralized matrix borders. The cell detritus is noted in zones of surface dissolving among crystallic conglomerates. It certificates the processes of osteogenic cells destruction that happen here. So, under the microgravity conditions in zones of adaptive remodeling of the spongiose the processes of the bone tissue resorption happen by some ways, namely: by the functional activization of osteoclasts; by the osteocytic osteolysis increasing; as a result of hydrolytic activity of neutrophiles, entering in these zones, and also by the local demineralization and further destruction of bone matrix surface zones.

Rodionova, N.; Oganov, V.; Polkovenko, O.; Nitsevich, T.

223

Facial alveolar bone wall width - a cone-beam computed tomography study in Asians.  

UK PubMed Central (United Kingdom)

BACKGROUND: The width of the facial alveolar bone wall is crucial for long-term successful esthetic outcomes of implants immediately placed into extraction sockets. A threshold of 2 mm is recommended to minimize buccal vertical bone resorption. AIM: To assess the width of the facial alveolar bone wall using cone-beam computed tomography images (CBCT). MATERIAL AND METHODS: Retrospective CBCT images were acquired from a representative sample of Asians using the i-CAT(®) classic system with a 0.4-mm voxel size. At random, 200 CBCT images were selected according to predefined criteria. The DICOM file was imported into the i-CAT Vision(®) software. In the panoramic screen, the middle of each tooth was selected, and in the sagittal window, the middle cross section was selected for performing the measurements using a computer. The vertical distance from the alveolar crest (BC) - cemento-enamel junction (CEJ) was measured. The width of the facial alveolar bone wall was measured at three locations: 1, 3, and 5 mm apical to BC. Descriptive statistics, frequency analyses, and multi-level comparisons were performed. RESULTS: The sample consisted of 74 men and 126 women (mean age of 37.2 years; range 17-82years). A total of 3618 teeth were assessed. There was no significant difference between the values of right and left sides, or between genders. However, statistically significant differences were observed between age groups at all levels. The distance from CEJ to BC varied from 0.4 to 4 mm, with an overall tendency to increase with age. The mean width of the facial alveolar bone wall at anterior teeth was 0.9 mm and increased toward posterior regions. Rarely, a width of 2 mm was yielded (0.6-1.8% for anterior teeth, 0.7-30.8% for posterior teeth). At a 5-mm distance from BC, minimal widths of facial alveolar bone were identified for the anterior teeth. The frequency of dehiscence ranged from 9.9% to 51.6% for anterior and 3.1% to 53.6% for posterior teeth, respectively. CONCLUSION: A thin facial alveolar bone wall was usually present in both jaws. Hence, for most patients, adjunctive bone augmentation may be needed when installing implants in areas of esthetic concern.

Zekry A; Wang R; Chau AC; Lang NP

2013-01-01

224

Facial alveolar bone wall width - a cone-beam computed tomography study in Asians.  

Science.gov (United States)

BACKGROUND: The width of the facial alveolar bone wall is crucial for long-term successful esthetic outcomes of implants immediately placed into extraction sockets. A threshold of 2 mm is recommended to minimize buccal vertical bone resorption. AIM: To assess the width of the facial alveolar bone wall using cone-beam computed tomography images (CBCT). MATERIAL AND METHODS: Retrospective CBCT images were acquired from a representative sample of Asians using the i-CAT(®) classic system with a 0.4-mm voxel size. At random, 200 CBCT images were selected according to predefined criteria. The DICOM file was imported into the i-CAT Vision(®) software. In the panoramic screen, the middle of each tooth was selected, and in the sagittal window, the middle cross section was selected for performing the measurements using a computer. The vertical distance from the alveolar crest (BC) - cemento-enamel junction (CEJ) was measured. The width of the facial alveolar bone wall was measured at three locations: 1, 3, and 5 mm apical to BC. Descriptive statistics, frequency analyses, and multi-level comparisons were performed. RESULTS: The sample consisted of 74 men and 126 women (mean age of 37.2 years; range 17-82years). A total of 3618 teeth were assessed. There was no significant difference between the values of right and left sides, or between genders. However, statistically significant differences were observed between age groups at all levels. The distance from CEJ to BC varied from 0.4 to 4 mm, with an overall tendency to increase with age. The mean width of the facial alveolar bone wall at anterior teeth was 0.9 mm and increased toward posterior regions. Rarely, a width of 2 mm was yielded (0.6-1.8% for anterior teeth, 0.7-30.8% for posterior teeth). At a 5-mm distance from BC, minimal widths of facial alveolar bone were identified for the anterior teeth. The frequency of dehiscence ranged from 9.9% to 51.6% for anterior and 3.1% to 53.6% for posterior teeth, respectively. CONCLUSION: A thin facial alveolar bone wall was usually present in both jaws. Hence, for most patients, adjunctive bone augmentation may be needed when installing implants in areas of esthetic concern. PMID:23294441

Zekry, Ahmed; Wang, Ren; Chau, Anson C M; Lang, Niklaus P

2013-01-01

225

Humoral Regulation of Osteoclasts and Their Role in Bone Resorption  

Directory of Open Access Journals (Sweden)

Full Text Available Osteoclasts are derived from the macrophage haematopoietic lineage, resemble monocyte-like phagocytic cells, and are involved in bone resorption. The cells of the bone and the immune system communicate by cytokines and growth factors. The discovery of the receptor activator of nuclear factor kappa B (RANK) signalling pathway in osteoclasts provides a deeper understanding of osteoclastogenesis, mechanisms of the activation of bone resorption, and how bone structure and mass are affected by hormones. Turk Jem 2008; 12: 12-7

Hatice Sebile Dökmeta?

2008-01-01

226

Postoperative assessment of secondary bone grafting to the alveolar cleft using three-dimensional cone beam computed tomography  

International Nuclear Information System (INIS)

Between 1995 and 2004, 282 alveolar bone grafts were performed in our department using particle cancellous bone from the iliac bone. To evaluate postoperative results the height of bone bridging was measured in a two-dimensional evaluation using dental radiographs. However, recently, with the development of three-dimension CT (3-D CT), three-dimensional evaluation of bone bridging is recommended. Therefore, since last year, we have been evaluating bone bridging using dental CT. In this paper, we report a diagnostic imaging method for bone grafting to the alveolar cleft. First, a horizontal line passing along the inferior border of the piriform aperture of the normal side on the 3-D picture is drawn and then a horizontal line passing through the tip of the labial alveolar ridge of the central incisor of the upper jaw of the normal side is drawn. Then the distance between these two horizontal lines is measured. Next, this distance is equally divided into five segments by four horizontal lines. The labial lingual width of the bone bridge of the alveolar cleft part from the axial view of the height of these four horizontal lines is compared to that of the alveolar bone of the normal side. These four compared values are called the progression of the alveolar cleft, and the results of the bone grafting are judged by these numbers. We are convinced that the results of bone grafting can be more easily understood using this progression than from the many axial views of 3-D CT. (author)

2006-01-01

227

Effect of fish oil on lipopolysaccharide-induced hydroxyapatite loss in rat alveolar bone: A Preliminary Study  

Directory of Open Access Journals (Sweden)

Full Text Available Dietary fish oil has been shown to inhibit bone resorption and, therefore, the aim of the present study was to test the hypothesis that fish oil alters lipopolysaccharide (LPS)-induced hydroxyapatite loss in rat alveolar bone. Rats were divided into four groups. The animals injected with saline or Escherichia coli-derived LPS into the maxillary alveolar mucosa on the buccoapical site of the molar region daily for 8 days were served as a negative or positive control, respectively. Other groups of animals were injected with LPS and orally treated with fish oil at the same day with or after LPS injection. The results of the present study showed that the hydroxyapatite contents of alveolar bone in rats treated with fish oil at the same day with or before LPS injection were significantly higher than those in rats injected with LPS alone, but still lower than those in untreated animals. Therefore, the present study suggests that oral treatment with fish oil may reduce LPS-induced hydroxyapatite loss in rat alveolar bone

Didin E. Indahyani; AL Supartinah Santoso; Totok Utoro; Marsetyawan HNE Soesatyo; Wihaskoro Sosroseno

2009-01-01

228

The controlled assisted ridge expansion technique for implant placement in the anterior maxilla: a technical note.  

UK PubMed Central (United Kingdom)

This technical report describes the simple and valuable technique of controlled assisted ridge expansion (CARE) for the esthetic zone of the anterior maxilla. Atrophic bone and narrow alveolar crests make implant bed preparation difficult. The highly predictable surgical technique of CARE for alveolar expansion uses periosteal containment and subperiosteal intrabony vertical releasing incisions efficiently. This allows for the expansion of narrow, anatomically limiting edentulous ridges. The precise and conservative use of Piezosurgery and assisted manipulation of the labialized bony pedicle by horizontal spreaders and rotary osteocondensers affords a highly predictable surgical procedure, which allows implants to be placed at the time of surgery, reducing patient treatment time, morbidity, functional losses, and overall cost, as well as increasing the native bone volume in the atrophic maxillary ridge.

Horrocks GB

2010-10-01

229

Metastatic angiosarcoma presenting as diffuse alveolar hemorrhage  

Directory of Open Access Journals (Sweden)

Full Text Available Angiosarcoma is a rare malignant neoplasm of the vascular or lymphatic endothe-lium. Diffuse alveolar hemorrhage is a rare presenting manifestation of angiosar-coma. We describe a case of pulmonary metastasis of angiosarcoma who presented with diffuse alveolar hemorrhage as initial manifestation.

Rai S; Barthwal M; Bhattacharya P; Bhargava S; Pethe M

2008-01-01

230

Metastatic angiosarcoma presenting as diffuse alveolar hemorrhage  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Angiosarcoma is a rare malignant neoplasm of the vascular or lymphatic endothe-lium. Diffuse alveolar hemorrhage is a rare presenting manifestation of angiosar-coma. We describe a case of pulmonary metastasis of angiosarcoma who presented with diffuse alveolar hemorrhage as initial manifestation.

Rai S; Barthwal M; Bhattacharya P; Bhargava S; Pethe M

231

Pulmonary Alveolar proteinosis: A case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Pulmonary alveolar proteinosis is a rare cause of diffuse infiltrative lung disease. Less than 400 cases were reported so far in world literature. Here we are presenting a case of alveolar proteinosis in a young male who had a rapidly progressing fulminant clinical course.

Ravindran C; Koshy S; Madhusudan.KS; Rajalakshmi PC; Rauf CP; Yusuf N

2003-01-01

232

Alveolar epithelial dynamics in postpneumonectomy lung growth.  

Science.gov (United States)

The intimate anatomic and functional relationship between epithelial cells and endothelial cells within the alveolus suggests the likelihood of a coordinated response during postpneumonectomy lung growth. To define the population dynamics and potential contribution of alveolar epithelial cells to alveolar angiogenesis, we studied alveolar Type II and I cells during the 21 days after pneumonectomy. Alveolar Type II cells were defined and isolated by flow cytometry using a CD45(-) , MHC class II(+) , phosphine(+) phenotype. These phenotypically defined alveolar Type II cells demonstrated an increase in cell number after pneumonectomy; the increase in cell number preceded the increase in Type I (T1?(+) ) cells. Using a parabiotic wild type/GFP pneumonectomy model, <3% of the Type II cells and 1% of the Type I cells were positive for GFP-a finding consistent with the absence of a blood-borne contribution to alveolar epithelial cells. The CD45(-) , MHC class II(+) , phosphine(+) Type II cells demonstrated the active transcription of angiogenesis-related genes both before and after pneumonectomy. When the Type II cells on Day 7 after pneumonectomy were compared to nonsurgical controls, 10 genes demonstrated significantly increased expression (P<0.05). In contrast to the normal adult Type II cells, there was notable expression of inflammation-associated genes (Ccl2, Cxcl2, Ifng) as well as genes associated with epithelial growth (Ereg, Lep). Together, the data suggest an active contribution of local alveolar Type II cells to alveolar growth. PMID:23408540

Chamoto, Kenji; Gibney, Barry C; Ackermann, Maximilian; Lee, Grace S; Konerding, Moritz A; Tsuda, Akira; Mentzer, Steven J

2013-03-01

233

Pulmonary alveolar microlithiasis in children  

Energy Technology Data Exchange (ETDEWEB)

Two asymptomatic Turkish sibs are presented, a 4-year-old boy and his 7-year-old sister, with pulmonary alveolar microlithiasis (PAM) confirmed by transbronchial lung biopsy and bronchoalveolar lavage. Chest radiographs and high resolution CT demonstrated wide-spread intra-alveolar calcifications in both lungs. The lesions were sharply defined and less than 1 mm in diameter. CT documented a high concentration of microliths along the bronchovascular bundles, the intralobular fissue and the (sub)pleural lung parenchyma. The combination of bronchoalveolar lavage and roentgenographic appearance in high resolution CT are characteristic and pathognomonic, and can confirm the diagnosis. The more severe changes in the elder sib and the radiographic controls suggest that the pulmonary disease may be progressive in our patients. The described family of consanguineous, unaffected parents with two affected and one healthy child confirmed the autosomal recessive inheritance of PAM (McKusick 265100). In addition, the affected girl had autosomal recessive Waardenburg-anophthalmia syndrome (McKusick 206920), raising the question of whether this is a chance occurrence or possibly a contiguous gene syndrome. (orig.)

Schmidt, H. [Center of Diagnostic Radiology, Frankfurt Univ. (Germany); Loercher, U. [Center of Diagnostic Radiology, Frankfurt Univ. (Germany); Kitz, R. [Center of Pediatrics, Frankfurt Univ. (Germany); Zielen, S. [Center of Pediatrics, Frankfurt Univ. (Germany); Ahrens, P. [Center of Pediatrics, Frankfurt Univ. (Germany); Koenig, R. [Inst. of Human Genetics, Frankfurt Univ. (Germany)

1996-01-01

234

Idiopathic condylar resorption: diagnosis, treatment protocol, and outcomes.  

UK PubMed Central (United Kingdom)

Idiopathic condylar resorption is a poorly understood progressive disease that affects the TMJ and that can result in malocclusion, facial disfigurement, TMJ dysfunction, and pain. This article presents the diagnostic criteria for idiopathic condylar resorption and a new treatment protocol for management of this pathologic condition. Idiopathic condylar resorption most often occurs in teenage girls but can occur at any age, although rarely over the age of 40 years. These patients have a common facial morphology including: (1) high occlusal and mandibular plane angles, (2) progressively retruding mandible, and (3) Class II occlusion with or without open bite. Imaging usually demonstrates small resorbing condyles and TMJ articular disk dislocations. A specific treatment protocol has been developed to treat this condition that includes: (1) removal of hyperplastic synovial and bilaminar tissue; (2) disk repositioning and ligament repair; and (3) indicated orthognathic surgery to correct the functional and esthetic facial deformity. Patients with this condition respond well to the treatment protocol presented herein with elimination of the disease process. Two cases are presented to demonstrate this treatment protocol and outcomes that can be achieved. Idiopathic condylar resorption is a progressive disease that can be eliminated with the appropriate treatment protocol.

Wolford LM; Cardenas L

1999-12-01

235

[Bidirectional and unidirectional distraction of defects of the alveolar process comparative clinical study  

UK PubMed Central (United Kingdom)

AIM: The purpose of the retrospective study was to compare bidirectional distraction osteogenesis with the currently used unidirectional method of alveolar ridge distraction with regard to bone height attained and complications. PATIENTS AND METHODS: Overall 21 patients were treated by distraction osteogenesis for localized defects of the alveolar ridge. Vertical augmentation of the mandible and maxilla was performed using 10 unidirectional (group A) and 12 bidirectional (group B) devices. The effect of therapy was evaluated by height of bone gain and observed complications. RESULTS: The average gain of vertical bone height was approximately 6 mm. No statistically significant differences occurred between the two treatment groups (p=0.09). For the entire study two complications were observed: beside breakage of a distractor device (unidirectional distraction) an infection during the retention time (bidirectional distraction) developed. CONCLUSIONS: It could be shown that osteodistraction is a potentially valuable therapy for the correction of alveolar defects. We observed complications in both groups. No statistical differences were noted in regard to gained bone height and complications between the two groups.

Schleier P; Siebert HG; Wolf Ch; Berndt A; Schumann D

2006-03-01

236

Identification of A Novel Root Resorptive Function of Osteopontin Gene  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: Osteopontin (OPN) has been proposed to play a role in bone resorption. With regard to bone and cementum/dentin structural and histological similarities, it was hy-pothesized that expression of this gene might be increased in resorptive lacunae during orthodontic tooth movement.Materials and Methods: Fixed Nickel-Titanium closed coil springs (Dentaurum®) capa-ble of delivering approximately 60 gf were applied for mesial movement of maxillary left first molars in 26 male 8-week-old Wistar rats. The right maxillary molar served as inter-nal control for each subject. After 21 days, the rats were sacrificed. Tissues from 13 rats were examined by histomorphometric analysis and the scratched material from resorptive lacunae on mesial sides of the roots was used for extracting messenger ribonucleic acid (mRNA) in RT-PCR reactions. T-test and Wilcoxon signed-rank test served for statistical analyses.Results: Histomorphometric analysis of histologic sections revealed an increased resorbed area in test group compared to control animals (P<0.001). The integrity of mRNA con-firmed by RT-PCR for housekeeping gene glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Densitometric analysis of OPN mRNA on electrophoresis gel showed an in-crease in background levels of OPN in resorptive lacunae of test group (P<0.001).Conclusion: Data indicates that in the controlled environment of this study, an increase in OPN expression is associated with root resorption induced by orthodontic tooth move-ment.

M. Seifi; M. Jessri; E. Vahid-Dastjerdi

2008-01-01

237

[Evaluation of the accuracy of alveolar bone height measurement in vitro by cone beam computed tomography].  

UK PubMed Central (United Kingdom)

OBJECTIVE: To evaluate the accuracy and repeatability of alveolar bone height measurement in vitro by cone beam computed tomography (CBCT), and to provide theoretical application of CBCT in periodontal clinic. METHODS: Eight dry mandibles with 236 selected markers were scanned by CBCT scanner, and the distance from alveolar ridge crest to cemento-enamel junction were measured on every marker by the images of CBCT. Meanwhile the distances on the dry mandibles were measured directly by vernier caliper. All the data were analyzed by SPSS 13.0 statistics software. RESULTS: There was no significant difference between the two repeated measurements by the CBCT images (P >0.05), and no significant difference were found between the measurement by the CBCT images and by vernier caliperas well (P > 0.05). CONCLUSION: The CBCT images could demonstrate the three-dimensional relationships between tooth and alveolar bone accurately. As far as the height of alveolar bone measurement was concerned, CBCT show good accuracy and repeatability in vitro.

Fang D; Jiang H; Lin Z

2012-12-01

238

Oral and dental restoration of wide alveolar cleft using distraction osteogenesis and temporary anchorage devices.  

UK PubMed Central (United Kingdom)

Closure of large alveolar clefts and restoration by a fixed bridge supported by implants is a challenge in cleft alveolus treatment. A major aesthetic concern with distraction osteogenesis is obtaining a predictable position of the implant in relation to the newly generated bony alveolar ridge. We describe the treatment of a large cleft alveolus and palate reconstruction by distraction osteogenesis utilizing temporary anchorage devices (TADs) followed by a fixed implant-supported bridge. The method consists of segmental bone transport by distraction osteogenesis using a bone-borne distractor to minimize the alveolar cleft, followed by closure of the residual small defect by bone grafting three months later. During the active transport distraction, TADs were used exerting multidirectional forces to control the distraction vector forward and laterally for better interarch relation. A vertical alveolar distraction of the newly reconstructed bone of 15 mm facilitated optimal implant placement. The endosseous implants were osteointegrated and supported a fixed dental prosthesis. In conclusion, the large cleft alveolus defect was repaired in three dimensions by distraction osteogenesis assisted by TADs, and the soft tissues expanded simultaneously. Endosseous implants were introduced in the newly reconstructed bone for a fixed dental prosthesis enabling, rehabilitation of aesthetics, eating and speaking.

Rachmiel A; Emodi O; Gutmacher Z; Blumenfeld I; Aizenbud D

2013-02-01

239

[The mechanism of osteoprosis revealed by the animal studies: the involvement of alveolar bone resorption induced by the periodontal disease].  

UK PubMed Central (United Kingdom)

The experimental model of ovariectomy (OVX) has been well used as a model for studying the pathogenesis of postmenopausal osteoporosis. It is known that the hematopoietic environment in the bone marrow is altered leading to the up-regulation of osteoclastogenesis after the estrogen withdrawal. We discuss the possibility whether this alternation of lymphocyte-lineage cells could trigger off a risk factor for the periodontal disease.

Aoki K; Ohya K

2003-05-01

240

Fluoride effect on the process of alveolar bone repair in rats: evaluation of activity of MMP-2 and 9  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: The aim of this study was to evaluate comparatively the effect of fluoride (F) on the activity of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) involved in process of alveolar bone repair. Material and methods: This study used 4 groups of Wistar rats with 80 days of life (n = 160) which received drinking water containing different doses of fluoride (NaF): 5, 15, 50 ppm and deionized water (control) throughout the experiment. These animals had their right upper incisors extracted. After extraction, the animals were euthanized at 7, 14, 21 and 30 days and the hemi-maxillae were collected for microscopic analysis (Hematoxylin and Eosin and immunohistochemistry for MMP-9) and zymography (MMP-2 and 9). Results: Microscopically the process of bone repair was similar in all groups, being noted only a delay of the blood clot resorption and bone formation in the group of 50 ppm F. The expression for MMP-9 showed differences between groups only during the initial repair (7 days). However, the zymography showed no significant differences between treated and control groups. Conclusion: Ours results suggest an effect of fluoride on the activity of MMPs 2 and 9 at the initial period of alveolar repair which could be associated to the process of blood clot remission and delay in bone repair. Further studies are needed to establish the relationship between the initial process of resorption of the blood clot, and the involvement of MMPs 2 and 9 and its regulators/tissue inhibitors.

Mileni da Silva Fernandes; Gisele Miyamura Martins; Lucas Makoto Shimoraha; Flávia Godoy Iano; Marcela Mitsuko Yanai; Tânia Mary Cestari; Marília Afonso Rabelo Buzalaf; Rodrigo Cardoso de Oliveira

2012-01-01

 
 
 
 
241

Seasonal Variation of Nutrient Resorption in Nine Canopy Trees of a Wet Tropical Forest  

Science.gov (United States)

Withdrawal of nutrients at the time of leaf abscission (nutrient resorption) is a nutrient conserving mechanism that could play an important role in stand-level nutrient economy. Currently data on nutrient resorption in wet tropical forests and on how this process varies temporally are sparse. We evaluated the N and P resorption efficiency of nine rain forest canopy tree species in both wet and dry season months. In addition, we measured short-term (bi-weekly) variation in nutrient resorption in the two dominant tree species, Pentaclethra macroloba and Laetia procera, over a 4-month period. We hypothesized that nutrient resorption would be more efficient during the dry season months and that resorption would be low during periods of high rainfall. Contrary to expectations, P resorption efficiency was higher in the wet season for four of the nine canopy tree species, while N resorption did not differ seasonally. The low dry season P resorption efficiency found in this study may be the result of drought stress during short periods of low rainfall, leading to incomplete nutrient resorption from senescing leaves. Nutrient resorption also varied significantly over the short-term. Both P and N resorption efficiency increased in P. macroloba and L. procera as the wet season progressed. The variability in resorption was not related to rainfall or temperature. Instead, the senesced leaf concentrations were a simple proportion of green leaf nutrient concentrations, with short punctuated periods of high resorption efficiency that may be reflective of species-specific phenological events, such as fruit and leaf production. The different timing of the seasonal increase in nutrient resorption between L. procera and P. macroloba supports this hypothesis, deserving of further study.

Wood, T. E.; Lawrence, D.

2006-12-01

242

Minimax Ridge Regression Estimation.  

Science.gov (United States)

The technique of ridge regression has become a popular tool for data analysts faced with a high degree of multicollinearity in their data. By using a ridge estimator, it was hoped that one could both stabilize the estimates (lower the condition number of ...

G. Casella

1977-01-01

243

Reduction of precocious peri-implant resorption cone.  

UK PubMed Central (United Kingdom)

Aim: After implant-insertion, bone tissue, newly-formed on peri-implant crest, undergoes to a mild marginal osseous readjustment due to build-up of inflammatory cell tissue (ICT). The present study verifies the possibility to limit bone resorption by placing implant fixtures 0.5 mm outside cortical bone edge. Methods: A clinically-controlled randomized study on 100 implants has been performed to compare early resorption process of implant fixtures placed 0.5 mm outside cortical bone edge with implant-fixtures inserted according to juxtacortical bone conventional protocols. Results: After 6 months, bone implant level was higher with emersion approach (-1.01±0.54 mm, mean±SD) than with submerged treatment (-1.56±0.5 mm) (P<0.001). Conclusion: Factors to achieve an excellent result at mean-long term seem to be very good, even though the latter have to be confirmed by follow-up.

De Santis D; Zanotti G; Morandini S; Bordanzi A; Gerosa R; Rodella LF; Rossetto A; Chiarini L; Nocini PF; Bertossi D

2013-08-01

244

Stenosis of the nerve root canal caused by disc resorption.  

Science.gov (United States)

Stenosis of the nerve root canal caused by isolated resorption of a lumbar disc is a frequently observed pathology, but one about which the orthopaedist still knows relatively little. Henry Crock was the first to reveal its principal pathogenetic factor, disc resorption, and to accurately describe the syndrome and its surgical treatment. A total of 22 patients operated according to Henry Crock's indications and followed-up after 2 years were reviewed. In 20 cases decompression alone was performed, while in 2 cases anterior fusion and MOSS instrumentation were associated. Of the 22 patients submitted to decompression 17 revealed complete regression of pain. Three cases failed: 1 patient had previously been treated with chymopapain, while 3 are awaiting anterior fusion to treat persistent lumbar pain. Follow-up is not sufficient for the two patients submitted to anterior fusion. PMID:1587162

Gallinaro, P; Indemini, E; Tabasso, G; Massazza, G

245

[Alveolar echinococcosis--a new emerging disease?  

UK PubMed Central (United Kingdom)

Alveolar echinococcosis is a rare zoonotic disease caused by the cestode larval stages of Echinococcus multilocularis. The Larva develops as a tumour like cyst (hydatid). Due to a slow cyst development, the early stage of the infection is always asymptomatic and the clinical symptoms develop after years later. In the Czech Republic the disease is still very rare. Only one alveolar echinococcosis case was reported 30 years ago. However, new alveolar echinococcosis cases occurred during last two years and some of them indicate autochtonic character of the transmission. With regard to the recent increasing risk of infection with E. multilocularis in Central Europe, we present two case reports of alveolar echinococcosis in a 33-year old woman and a 24-year old man. The reports show diagnostic process and therapy of the infection.

Hozáková-Lukácová L; Kolárová L; Roznovský L; Hiemer I; Denemark L; Curík R; Dvorácková J

2009-01-01

246

Forceps extraction of teeth with severe internal root resorption.  

UK PubMed Central (United Kingdom)

Many treatment plans require a dental practitioner to maintain the entire labial cortical plate of bone when removing an anterior maxillary tooth. A tooth with an undermined root secondary to an endodontic perforation or internal (Idiopathic) resorption can present a surgical challenge to the general practitioner. This article describes a new technique for extracting a severely undermined anterior maxillary tooth while maintaining the entire labial cortex of bone.

Javaheri DS; Garibaldi JA

1997-06-01

247

Soluble silica inhibits osteoclast formation and bone resorption in vitro.  

UK PubMed Central (United Kingdom)

Several studies have suggested that silicon (Si) may be essential for normal development of connective tissue and the skeleton. Positive effects of Si from the diet as well as from Si-containing biomaterials, such as Bioactive glass 45S5 (BG), have been demonstrated. Studies have reported that Si stimulates osteoblast proliferation and differentiation. However, effects of Si on osteoclasts have not been directly addressed earlier. The purpose of the present in vitro study was to clarify if Si has regulatory effects on osteoclasts formation and bone resorption. Effects of BG, BG dissolution extracts and Si containing cell culture medium were investigated in a mouse calvarial bone resorption assay and osteoclast formation assays (mouse bone marrow cultures and RAW264.7 cell cultures). We conclude from our results that Si causes significant inhibition of osteoclast phenotypic gene expressions, osteoclast formation and bone resorption in vitro. In conclusion, the present study suggests that Si has a dual nature in bone metabolism with stimulatory effects on osteoblasts and inhibitory effects on osteoclasts. This suggested property of Si might be interesting to further explore in future biomaterials for treatments of bone defects in patients.

Mladenovi? Z; Johansson A; Willman B; Shahabi K; Björn E; Ransjö M

2013-09-01

248

Albendazole and alveolar disease: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Hydatidsis is a zoonosis transmitted by domestic and wild animals. Two distinct clinical presentations are as followes: unilocular of cystic hydatid disease and the more malignant form, called alveolar hydatid disease.This case report presents a patient who complained of chest pain and hemoptysis and his lung CT scan suggested solid tumor. He was found to have alveolar diseae which responded to albendazole medical therapy

Daneshjou Kh; Haghshenas Z

2002-01-01

249

Fatal alveolar echinococcosis of the lumbar spine.  

UK PubMed Central (United Kingdom)

For the last 10 years, the southern part of Belgium has been recognized as a low-risk area of endemicity for alveolar echinococcosis. This infection, caused by Echinococcus multilocularis, usually induces a severe liver condition and can sometimes spread to other organs. However, alveolar echinococcosis involving bones has been described only very rarely. Here, a fatal case of spondylodiscitis due to E. multilocularis contracted in southern Belgium is reported.

Keutgens A; Simoni P; Detrembleur N; Frippiat F; Giot JB; Spirlet F; Aghazarian S; Descy J; Meex C; Huynen P; Melin P; Müller N; Gottstein B; Carlier Y; Hayette MP

2013-02-01

250

Alveolar hydatid cyst: A case report  

Directory of Open Access Journals (Sweden)

Full Text Available Alveolar hydatid cyst is a parasitic disease due to invasion of the Echinococcus multilocularis larva into the different tissues. The main host of this tape worms is Canidae family, especially foxes and jackals. Human beings are usually infected through eating contaminated vegetables and water with parasite eggs. In this article, one case of alveolar hydatid cyst has been reported in a 35 year-old woman

Mohammad A. Raiesolsadat; S. Ali Mirsadeghi; Mohammad A. Yaghoubi; Armin Elahifar; Behiye Zarif-Zakerian

2010-01-01

251

Alveolarization Continues during Childhood and Adolescence  

Science.gov (United States)

Rationale: The current hypothesis that human pulmonary alveolarization is complete by 3 years is contradicted by new evidence of alveolarization throughout adolescence in mammals. Objectives: We reexamined the current hypothesis using helium-3 (3He) magnetic resonance (MR) to assess alveolar size noninvasively between 7 and 21 years, during which lung volume nearly quadruples. If new alveolarization does not occur, alveolar size should increase to the same extent. Methods: Lung volumes were measured by spirometry and plethysmography in 109 healthy subjects aged 7–21 years. Using 3HeMR we determined two independent measures of peripheral airspace dimensions: apparent diffusion coefficient (ADC) of 3He at FRC (n = 109), and average diffusion distance of helium (Xrms¯) by q-space analysis (n = 46). We compared the change in these parameters with lung growth against a model of lung expansion with no new alveolarization. Measurements and Main Results: ADC increased by 0.19% for every 1% increment in FRC (95% confidence interval [CI], 0.13–0.25), whereas the expected change in the absence of neoalveolarization is 0.41% (95% CI, 0.31–0.52). Similarly, increase of (Xrms¯) with FRC was significantly less than the predicted increase in the absence of neoalveolarization. The number of alveoli is estimated to increase 1.94-fold (95% CI, 1.64–2.30) across the age range studied. Conclusions: Our observations are best explained by postulating that the lungs grow partly by neoalveolarization throughout childhood and adolescence. This has important implications: developing lungs have the potential to recover from early life insults and respond to emerging alveolar therapies. Conversely, drugs, diseases, or environmental exposures could adversely affect alveolarization throughout childhood.

Owers-Bradley, John; Beardsmore, Caroline S.; Mada, Marius; Ball, Iain; Garipov, Ruslan; Panesar, Kuldeep S.; Kuehni, Claudia E.; Spycher, Ben D.; Williams, Sian E.; Silverman, Michael

2012-01-01

252

Lung epithelial branching program antagonizes alveolar differentiation.  

UK PubMed Central (United Kingdom)

Mammalian organs, including the lung and kidney, often adopt a branched structure to achieve high efficiency and capacity of their physiological functions. Formation of a functional lung requires two developmental processes: branching morphogenesis, which builds a tree-like tubular network, and alveolar differentiation, which generates specialized epithelial cells for gas exchange. Much progress has been made to understand each of the two processes individually; however, it is not clear whether the two processes are coordinated and how they are deployed at the correct time and location. Here we show that an epithelial branching morphogenesis program antagonizes alveolar differentiation in the mouse lung. We find a negative correlation between branching morphogenesis and alveolar differentiation temporally, spatially, and evolutionarily. Gain-of-function experiments show that hyperactive small GTPase Kras expands the branching program and also suppresses molecular and cellular differentiation of alveolar cells. Loss-of-function experiments show that SRY-box containing gene 9 (Sox9) functions downstream of Fibroblast growth factor (Fgf)/Kras to promote branching and also suppresses premature initiation of alveolar differentiation. We thus propose that lung epithelial progenitors continuously balance between branching morphogenesis and alveolar differentiation, and such a balance is mediated by dual-function regulators, including Kras and Sox9. The resulting temporal delay of differentiation by the branching program may provide new insights to lung immaturity in preterm neonates and the increase in organ complexity during evolution.

Chang DR; Martinez Alanis D; Miller RK; Ji H; Akiyama H; McCrea PD; Chen J

2013-09-01

253

Pulmonary alveolar lipoproteinosis associated with emphysematous areas.  

UK PubMed Central (United Kingdom)

Pulmonary alveolar lipoproteinosis, described for the first time in 1958 by Rosen SH, Castleman B and Liebow AA, is a rare pathological condition characterized by alveolar accumulation of lipoproteinaceous material. It is the result of macrophages impairment to rid the alveolar spaces of spent surfactant. This condition involves a restrictive function of pulmonary tissue, reflected in gas exchange impairment and respiratory symptoms of variable severity. Until now, about 410 cases have been reported in the literature. From these cases, 90% were represented by primary type of pulmonary alveolar lipoproteinosis. We present the case of 37-year-old male patient admitted in the Department of Internal Medicine, Emergency County Hospital, Constanta, Romania, with progressive exertional dyspnea, dry cough and perioral cyanosis. The clinical symptoms started three months before hospital admission. Based on clinical findings and imaging features, the primary pulmonary alveolar proteinosis diagnosis has been suspected. Uncharacteristic serous aspect of fluid resulting from bronchoalveolar lavage required open lung biopsy. Pathologic examination of pulmonary slice revealed features consistent with the diagnosis of pulmonary alveolar lipoproteinosis associated with emphysematous foci. The peculiarity of this case lies in the association of two pathological conditions, each of them requiring different pathways.

Deacu M; Tofolean DE; Bo?oteanu M; A?chie M; Bulbuc I

2012-01-01

254

Botryllus schlosseri (Tunicata) whole colony irradiation: Do senescent zooid resorption and immunological resorption involve similar recognition events  

International Nuclear Information System (INIS)

The colonial tunicate Botryllus schlosseri undergoes cyclic blastogenesis where feeding zooids are senescened and resorbed and a new generation of zooids takes over the colony. When non-identical colonies come into direct contact, they either reject each other or fuse. Fusion is usually followed by the resorption of one of the partners in the chimera (immunological resorption). The striking morphological similarities between the two resorption phenomena suggest that both may involve tissue destruction following self-nonself recognition events. Here we attempt to modify these two events by whole colony gamma irradiation assays. Three sets of experiments were performed: (1) different doses of whole colony irradiation for determination of irradiation effects (110 colonies); (2) pairs of irradiated-nonirradiated isografts of clonal replicates for the potential of reconstruction of the irradiated partners (23 pairs); (3) chimeras of irradiated-nonirradiated partners for analysis of resorption hierarchy. Mortality increased with the irradiation dose. All colonies exposed to more than 5,000 rads died within 19 days, while no colony died below 2,000 rads. The average mortality periods, in days, for doses of 6,000-8,000, 5,000, and 2,500-4,000 rads were 14.4 +/- 3.1 (n = 24), 19.8 +/- 6.0 (n = 15), and 19.6 + 5.1 (n = 22), respectively. Younger colonies (3-6 months old) may survive radiation better than older ones (more than 13 months). Many morphological alterations were recorded in irradiated colonies: ampullar contraction and/or dilation, accumulation of pigment cells within ampullae, abnormal bleeding from blood vessels, sluggish blood circulation, necrotic zones, reduction in bud number, and irregularities in zooid and system structures. With doses of 3,000-4,000 rads and above, irradiation arrested the formation of new buds and interrupted normal takeover

1990-01-01

255

Compression-absorption (resorption) refrigerating machinery. Modeling of reactors; Machine frigorifique a compression-absorption (resorption). Modelisation des reacteurs  

Energy Technology Data Exchange (ETDEWEB)

This paper is a series of transparencies presenting a comparative study of the thermal performances of different types of refrigerating machineries: di-thermal with vapor compression, tri-thermal with moto-compressor, with ejector, with free piston, adsorption-type, resorption-type, absorption-type, compression-absorption-type. A prototype of ammonia-water compression-absorption heat pump is presented and modeled. (J.S.)

Lottin, O.; Feidt, M.; Benelmir, R. [LEMTA-UHP Nancy-1, 54 - Vandoeuvre-les-Nancy (France)

1997-12-31

256

Botryllus schlosseri (Tunicata) whole colony irradiation: Do senescent zooid resorption and immunological resorption involve similar recognition events  

Energy Technology Data Exchange (ETDEWEB)

The colonial tunicate Botryllus schlosseri undergoes cyclic blastogenesis where feeding zooids are senescened and resorbed and a new generation of zooids takes over the colony. When non-identical colonies come into direct contact, they either reject each other or fuse. Fusion is usually followed by the resorption of one of the partners in the chimera (immunological resorption). The striking morphological similarities between the two resorption phenomena suggest that both may involve tissue destruction following self-nonself recognition events. Here we attempt to modify these two events by whole colony gamma irradiation assays. Three sets of experiments were performed: (1) different doses of whole colony irradiation for determination of irradiation effects (110 colonies); (2) pairs of irradiated-nonirradiated isografts of clonal replicates for the potential of reconstruction of the irradiated partners (23 pairs); (3) chimeras of irradiated-nonirradiated partners for analysis of resorption hierarchy. Mortality increased with the irradiation dose. All colonies exposed to more than 5,000 rads died within 19 days, while no colony died below 2,000 rads. The average mortality periods, in days, for doses of 6,000-8,000, 5,000, and 2,500-4,000 rads were 14.4 +/- 3.1 (n = 24), 19.8 +/- 6.0 (n = 15), and 19.6 + 5.1 (n = 22), respectively. Younger colonies (3-6 months old) may survive radiation better than older ones (more than 13 months). Many morphological alterations were recorded in irradiated colonies: ampullar contraction and/or dilation, accumulation of pigment cells within ampullae, abnormal bleeding from blood vessels, sluggish blood circulation, necrotic zones, reduction in bud number, and irregularities in zooid and system structures. With doses of 3,000-4,000 rads and above, irradiation arrested the formation of new buds and interrupted normal takeover.

Rinkevich, B.; Weissman, I.L. (Israel Oceanographic and Limnological Research, Haifa (Israel))

1990-02-01

257

A radiologic study of the teeth resorption in the area of a ameloblastoma  

International Nuclear Information System (INIS)

An ameloblastoma produces more extensive resorption of the teeth on which it encroaches than do most of the other lesions. In this study, intraoral and extraoral radiographs of 78 cases of ameloblastoma were observed and the root resorption associated with ameloblastoma was classified into four types of resorption. With these, the following conclusions were obtained. 1. The root resorption was observed in 72 cases of ameloblastoma. (92.3%) 2. In the aspect of resorptive changes of 424 roots observed, 342 roots showed smooth resorption. (80.6%) 3. The 424 roots associated with ameloblastoma revealed the following radiographic features. a) Root apex resorption in contact with the lesion appeared in 189 roots. (44.5%) b) The resorption of roots projected into the lesion appeared in 147 roots. (34.5%) c) Slight resorption of root surface in contact with the lesion was observed in 56 roots. (13.2%) d) Loss of lamina dura and periodontal space without root resorption were observed in 32 roots. (7.7%)

1980-01-01

258

A radiologic study of the teeth resorption in the area of a ameloblastoma  

Energy Technology Data Exchange (ETDEWEB)

An ameloblastoma produces more extensive resorption of the teeth on which it encroaches than do most of the other lesions. In this study, intraoral and extraoral radiographs of 78 cases of ameloblastoma were observed and the root resorption associated with ameloblastoma was classified into four types of resorption. With these, the following conclusions were obtained. 1. The root resorption was observed in 72 cases of ameloblastoma. (92.3%) 2. In the aspect of resorptive changes of 424 roots observed, 342 roots showed smooth resorption. (80.6%) 3. The 424 roots associated with ameloblastoma revealed the following radiographic features. a) Root apex resorption in contact with the lesion appeared in 189 roots. (44.5%) b) The resorption of roots projected into the lesion appeared in 147 roots. (34.5%) c) Slight resorption of root surface in contact with the lesion was observed in 56 roots. (13.2%) d) Loss of lamina dura and periodontal space without root resorption were observed in 32 roots. (7.7%)

Yee, Choon Aei; Park, Tae Won [Yonsei University College of Medicine, Seoul (Korea, Republic of)

1980-11-15

259

Morphological characteristics of dentitions developing excessive root resorption during orthodontic treatment.  

UK PubMed Central (United Kingdom)

The present study focuses on orthodontically provoked, excessive root resorption. The purpose was to identify in these cases common morphological features in radiographic diagnostic material taken before treatment. The material was submitted by 35 Danish orthodontists. The goal was to improve the future orthodontic diagnostics of the dentition in order to prevent severe root resorption during treatment. The study indicates that: (1) there is a strong connection between various dental morphological characteristics, such as invagination, length of root, and root shapes, especially taurodontism, and the tendency to root resorption during orthodontic treatment; (2) there is a connection between anomalies in the dentition, particularly ectopia and agenesis, and the tendency to root resorption during orthodontic treatment; (3) there seems to be a connection between the pattern of resorption in the primary dentition and the tendency to root resorption in the permanent dentition following orthodontic treatment; (4) girls are more susceptible to root resorption during orthodontic treatment than boys; (5) one ought to be on the lookout for connections between condylar changes, root resorptions, and anterior open bites in connection with orthodontic treatment. The observation regarding root resorption in dentitions in which invaginations and taurodontic root shapes occur has not previously been reported. Also, the findings of deviant resorption patterns in both the primary and permanent dentitions in a considerable number of patients are new observations, which ought to be incorporated into orthodontic treatment planning.

Kjaer I

1995-02-01

260

Identification of orthodontic patients at risk of severe apical root resorption.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Current information suggests that the major variation in orthodontic root resorption can be explained by differences in individual predisposition. Our aim was therefore to test the predictive value of the amount of maxillary incisor resorption about 6 and 12 months after bracket placement for the resorption at appliance removal. METHODS: We measured tooth length of the maxillary incisors on digitally converted periapical radiographs, adjusted for projection errors, made before treatment (T1), about 6 months (T2) and 12 months (T3) after bracket placement, and at the end of active treatment (T4) of 267 prospectively enrolled orthodontic patients, and interpreted reduced tooth length as apical root resorption. Anatomic and occlusal parameters were scored on the T1 radiographs and study models. Anamnestic and treatment parameters were collected from standardized recordings in the charts. RESULTS: The Spearman R for resorption of each incisor ranged from 0.61 to 0.76 at T2 vs T4, and from 0.77 to 0.88 at T3 vs T4 (P <0.001). Only 0.6% of the patients with no incisors with >1.0 mm of resorption at T2 and 0.5% of those with no incisors with >2.0 mm of resorption at T3 had at least 1 incisor with >5.0 mm of resorption at T4. Amount of resorption at T3 and maxillary tooth extraction were included in the final prediction model for resorption of the most severely affected central and lateral incisors at T4, with explained variances of 0.71 and 0.67, respectively. Treatment duration and time with square wires was not related to resorption (P >0.05). CONCLUSIONS: Patients at risk of severe apical root resorption can be identified according to the amount of resorption during the initial treatment stages.

Artun J; Van 't Hullenaar R; Doppel D; Kuijpers-Jagtman AM

2009-04-01

 
 
 
 
261

A scanning electron microscopic study of the patterns of external root resorption under different conditions  

Directory of Open Access Journals (Sweden)

Full Text Available OBJECTIVE: The aim of this study was to examine if there are qualitative differences in the appearance of external root resorption patterns of primary teeth undergoing physiologic resorption and permanent teeth undergoing pathological root resorption in different conditions. MATERIAL AND METHODS: A total of 40 teeth undergoing external root resorption in different conditions were divided into 4 groups and prepared for examination under scanning electron microscopy at magnifications ranging from 20x to 1000x. Group I: 10 primary molars exfoliated due to physiologic root resorption; Group II: 10 permanent teeth with periapical granulomas showing signs of resorption; Group III:10 permanent teeth therapeutically extracted during the course of orthodontic therapy with evidence of resorption, and Group IV: 10 permanent teeth associated with odontogenic tumors that showed evidence of resorption. RESULTS: In Group I, the primary teeth undergoing resorption showed smooth extensive and predominantly regular areas reflecting the slow ongoing physiologic process. In Group II, the teeth with periapical granulomas showed the resorption was localized to apex with a funnel shaped appearance in most cases. Teeth in Group III, which had been subjected to a short period of light orthodontic force, showed the presence of numerous resorption craters with adjoining areas of cemental repair in some cases. Teeth associated with odontogenic tumors in Group IV showed many variations in the patterns of resorption with extensive loss of root length and a sharp cut appearance of the root in most cases. CONCLUSION: Differences were observed in the patterns of external root resorption among the studied groups of primary and permanent teeth under physiologic and pathological conditions.

Ravindran Sreeja; Chaudhary Minal; Tumsare Madhuri; Patil Swati; Wadhwan Vijay

2009-01-01

262

RIDGE Multibeam Synthesis Project  

Science.gov (United States)

The RIDGE Program is a National Science Foundation initiative that promotes interdisciplinary study, scientific communication, and outreach related to all aspects of the globe-encircling, mid-ocean ridge system. The RIDGE Multibeam Synthesis Project site provides free access to downloadable multibeam bathymetric images and datasets of suboceanic ridges and vents. From either a hotlinked world map or a drop-down menu, users can specify the feature of interest - from the Reykjanes Ridge to the Shona Hotspot to the Galapagos Spreading Center - then progressively zoom to finer grid scales. The bathymetric images are depicted at different node spacings (100 m to 1500m) and grids are supported by the appropriate metadata. The images are also accompanied by ping data (including ship tracks) and other related data, which may include coaxial segment perspective images or isochron interpretation maps. Also, for many of the grids the user can specify subsample regions or retrieve contour areas of subregions. Links throughout the site include those to the main RIDGE page, a gallery of coaxial images, information on Served Data Formats, and the Principal Investigators involved with the Project.

263

Stresses in implant-supported overdentures with bone resorption: a 3-D finite element analysis/ Tensões em sobredentaduras com reabsorção óssea: análise por elementos finitos tridimensional  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: Avaliar, através da análise por elementos finitos com modelo tridimensional, o efeito da reabsorção óssea na distribuição de tensões em prótese tipo overdenture, em situações de perda óssea ao redor dos implantes e reabsorção do rebordo posterior. METODOLOGIA: Foram construídos modelos tridimensionais de uma mandíbula e de intermediários protéticos, prótese total, placa resiliente e implante. Os modelos geométricos dos implantes e intermediá (more) rios protéticos foram montados na região dos caninos, constituindo o modelo 1. Para a construção dos modelos experimentais, o contorno do modelo geométrico da mandíbula foi alterado para simular a perda óssea nos implantes (modelo 2) e a reabsorção do rebordo posterior associada à perda óssea marginal nos implantes (modelo 3). Para gerar a malha de elementos finitos os materiais foram considerados homogêneos, isotrópicos e linearmente elásticos. Uma carga de 100 N foi aplicada indiretamente, sobre uma simulação de bolo alimentar, na região de primeiro molar inferior direito em cada um dos três modelos. Foram analisadas as distribuições de tensão de von Mises em pontos pré-determinados. RESULTADOS: A reabsorção óssea do rebordo posterior associada à perda óssea do osso periimplantar promoveu maior concentração de tensões nos implantes, nos componentes protéticos e no tecido ósseo marginal. Houve maior concentração de tensões no osso periimplantar e nos implantes no mesmo lado de aplicação da carga. CONCLUSÃO: Os resultados sugerem que a perda óssea periimplantar aumenta a concentração de tensões nos implantes, pilares e osso marginal independentemente da reabsorção óssea na crista distal. Abstract in english PURPOSE: This 3D-finite elements method study evaluated the effect of bone resorption on the stress distribution in overdentures with bone loss surrounding implants and resorption of the distal ridge. METHODS: Tridimensional models were built from the images of a computerized tomography of a mandible and 3D laser digitalization of implants, abutments, mucosa, and complete denture. The geometric models of implants and abutments were mounted at the canine region to build re (more) ference model 1 - absence of bone resorption. To build the test models the mandible geometric solid was modified to simulate 2-mm vertical bone loss surrounding the implants (model 2) and resorption of the distal ridge (model 3). Finite elements models were generated, and a 100 N static load was applied at the first molar region of each model to compare the von Mises stress distributions in selected points. RESULTS: Von Mises stresses increased on the bone surrounding implants and on the prosthetic components in the model with 2-mm vertical bone loss. The combination of 2-mm vertical bone loss and resorption of the distal ridge did not increase the stresses compared with the model with only bone loss surrounding implants. The highest stress concentration at marginal bone and implants occurred on the same side of the vertical load application for all models. CONCLUSION: The results suggest that the bone loss surrounding implants increases stress concentration in dental implants, abutments, and marginal bone independently from the bone resorption of the distal ridge.

Mariano, Luiz Oscar Honorato; Sartori, Evandro Afonso; Broilo, Josué Ricardo; Shinkai, Rosemary Sadami; Corso, Leandro; Marczak, Rogério José

2012-01-01

264

The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats Influência da ovariectomia, da sinvastatina e do alendronato sódico no osso alveolar em ratas  

Directory of Open Access Journals (Sweden)

Full Text Available Bisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. Statins have been widely used for the treatment of hypercholesterolemia and recent studies have shown that these drugs are also capable of stimulating bone formation. The purpose of this study was to evaluate the influence of an estrogen deficient state and the effects of simvastatin and sodium alendronate therapies on alveolar bone in female rats. Fifty-four rats were either ovariectomized (OVX) or sham operated. A month later, the animals began to receive a daily dose of simvastatin (SIN - 25 mg/kg), sodium alendronate (ALN - 2 mg/kg) or water (control) orally. Thirty-five days after the beginning of the treatment, the rats were sacrificed and their left hemimandibles were removed and radiographed using digital X-ray equipment. The alveolar radiographic density under the first molar was determined with gray-level scaling and the values were submitted to analysis of variance (a = 5%). Ovariectomized rats gained more weight (mean ± standard deviation: 20.06 ± 6.68%) than did the sham operated animals (12.13 ± 5.63%). Alveolar radiographic density values, expressed as gray levels, were lowest in the OVX-water group (183.49 ± 6.47), and differed significantly from those observed for the groups receiving alendronate (sham-ALN: 193.85 ± 3.81; OVX-ALN: 196.06 ± 5.11) and from those of the sham-water group (193.66 ± 4.36). Other comparisons between groups did not show significant differences. It was concluded that the ovariectomy reduced alveolar bone density and that alendronate was efficient for the treatment of this condition.Os bisfosfonatos são empregados atualmente para o tratamento de várias doenças caracterizadas pelo aumento da reabsorção óssea, como a osteoporose. As estatinas são amplamente utilizadas para redução de níveis elevados de colesterol e estudos recentes têm revelado sua ação anabólica no osso. O objetivo deste trabalho foi avaliar a influência da deficiência estrogênica e dos tratamentos com sinvastatina ou alendronato sódico no osso alveolar em ratas. Cinqüenta e quatro ratas sofreram ovariectomia (OVX) ou cirurgia simulada ("sham"). Um mês após, os animais passaram a receber diariamente, via oral, 25 mg/kg de sinvastatina (SIN), 2 mg/kg de alendronato (ALN) ou água (controle). Trinta e cinco dias depois do início do tratamento os animais foram sacrificados, as hemimandíbulas esquerdas removidas e radiografadas em aparelho de raios X digital. Foi calculada a densidade radiográfica em tons de cinza da área de osso alveolar sob o primeiro molar mandibular e os valores foram submetidos a ANOVA, ao nível de 5%. Ratas ovariectomizadas ganharam mais peso (média ± desvio-padrão: 20,06 ± 6,68%) que as demais (12,13 ± 5,63%). Os valores de densidade radiográfica, em tons de cinza, foram menores nos animais do grupo OVX-água (183,49 ± 6,47), significantemente diferentes daqueles observados nos grupos que receberam alendronato ("sham"-ALN: 193,85 ± 3,81; OVX-ALN: 196,06 ± 5,11) e no grupo "sham"-água (193,66 ± 4,36). Outras comparações entre grupos não revelaram diferenças estatísticas. Concluiu-se que a ovariectomia reduziu a densidade óssea alveolar e que o tratamento com alendronato sódico foi eficiente para o tratamento desta situação.

Ana Lia Anbinder; Fernanda de Almeida Prado; Marcela de Almeida Prado; Ivan Balducci; Rosilene Fernandes da Rocha

2007-01-01

265

The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats/ Influência da ovariectomia, da sinvastatina e do alendronato sódico no osso alveolar em ratas  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Os bisfosfonatos são empregados atualmente para o tratamento de várias doenças caracterizadas pelo aumento da reabsorção óssea, como a osteoporose. As estatinas são amplamente utilizadas para redução de níveis elevados de colesterol e estudos recentes têm revelado sua ação anabólica no osso. O objetivo deste trabalho foi avaliar a influência da deficiência estrogênica e dos tratamentos com sinvastatina ou alendronato sódico no osso alveolar em ratas. Cin (more) qüenta e quatro ratas sofreram ovariectomia (OVX) ou cirurgia simulada ("sham"). Um mês após, os animais passaram a receber diariamente, via oral, 25 mg/kg de sinvastatina (SIN), 2 mg/kg de alendronato (ALN) ou água (controle). Trinta e cinco dias depois do início do tratamento os animais foram sacrificados, as hemimandíbulas esquerdas removidas e radiografadas em aparelho de raios X digital. Foi calculada a densidade radiográfica em tons de cinza da área de osso alveolar sob o primeiro molar mandibular e os valores foram submetidos a ANOVA, ao nível de 5%. Ratas ovariectomizadas ganharam mais peso (média ± desvio-padrão: 20,06 ± 6,68%) que as demais (12,13 ± 5,63%). Os valores de densidade radiográfica, em tons de cinza, foram menores nos animais do grupo OVX-água (183,49 ± 6,47), significantemente diferentes daqueles observados nos grupos que receberam alendronato ("sham"-ALN: 193,85 ± 3,81; OVX-ALN: 196,06 ± 5,11) e no grupo "sham"-água (193,66 ± 4,36). Outras comparações entre grupos não revelaram diferenças estatísticas. Concluiu-se que a ovariectomia reduziu a densidade óssea alveolar e que o tratamento com alendronato sódico foi eficiente para o tratamento desta situação. Abstract in english Bisphosphonates are currently used in the treatment of many diseases involving increased bone resorption such as osteoporosis. Statins have been widely used for the treatment of hypercholesterolemia and recent studies have shown that these drugs are also capable of stimulating bone formation. The purpose of this study was to evaluate the influence of an estrogen deficient state and the effects of simvastatin and sodium alendronate therapies on alveolar bone in female rats (more) . Fifty-four rats were either ovariectomized (OVX) or sham operated. A month later, the animals began to receive a daily dose of simvastatin (SIN - 25 mg/kg), sodium alendronate (ALN - 2 mg/kg) or water (control) orally. Thirty-five days after the beginning of the treatment, the rats were sacrificed and their left hemimandibles were removed and radiographed using digital X-ray equipment. The alveolar radiographic density under the first molar was determined with gray-level scaling and the values were submitted to analysis of variance (a = 5%). Ovariectomized rats gained more weight (mean ± standard deviation: 20.06 ± 6.68%) than did the sham operated animals (12.13 ± 5.63%). Alveolar radiographic density values, expressed as gray levels, were lowest in the OVX-water group (183.49 ± 6.47), and differed significantly from those observed for the groups receiving alendronate (sham-ALN: 193.85 ± 3.81; OVX-ALN: 196.06 ± 5.11) and from those of the sham-water group (193.66 ± 4.36). Other comparisons between groups did not show significant differences. It was concluded that the ovariectomy reduced alveolar bone density and that alendronate was efficient for the treatment of this condition.

Anbinder, Ana Lia; Prado, Fernanda de Almeida; Prado, Marcela de Almeida; Balducci, Ivan; Rocha, Rosilene Fernandes da

2007-09-01

266

Fusion-activated cation entry (FACE) via P2X? couples surfactant secretion and alveolar fluid transport.  

UK PubMed Central (United Kingdom)

Two fundamental mechanisms within alveoli are essential for lung function: regulated fluid transport and secretion of surfactant. Surfactant is secreted via exocytosis of lamellar bodies (LBs) in alveolar type II (ATII) cells. We recently reported that LB exocytosis results in fusion-activated cation entry (FACE) via P2X? receptors on LBs. We propose that FACE, in addition to facilitating surfactant secretion, modulates alveolar fluid transport. Correlative fluorescence and atomic force microscopy revealed that FACE-dependent water influx correlated with individual fusion events in rat primary ATII cells. Moreover, ATII cell monolayers grown at air-liquid interface exhibited increases in short-circuit current (Isc) on stimulation with ATP or UTP. Both are potent agonists for LB exocytosis, but only ATP activates FACE. ATP, not UTP, elicited additional fusion-dependent increases in Isc. Overexpressing dominant-negative P2X? abrogated this effect by ?50%, whereas potentiating P2X4 lead to ?80% increase in Isc. Finally, we monitored changes in alveolar surface liquid (ASL) on ATII monolayers by confocal microscopy. Only stimulation with ATP, not UTP, led to a significant, fusion-dependent, 20% decrease in ASL, indicating apical-to-basolateral fluid transport across ATII monolayers. Our data support the first direct link between LB exocytosis, regulation of surfactant secretion, and transalveolar fluid resorption via FACE.

Thompson KE; Korbmacher JP; Hecht E; Hobi N; Wittekindt OH; Dietl P; Kranz C; Frick M

2013-04-01

267

A COMPARISON OF COMPUTED TOMOGRAPHY SCANS AND DIGITAL PERIAPICAL RADIOGRAPHS RIDGE HEIGHT MEASUREMENTS.  

UK PubMed Central (United Kingdom)

Abstract Objectives: to investigate the agreement between computerized tomography scans (CT) and intra-oral periapical digital radiographs (PA) alveolar ridge height measurements in maxillary and mandibular posterior regions.Methods: We reviewed 100 implant patient radiographic records and identified 27 mandibular sites in 19 patients and 23 maxillary sites in 13 patients with available CT scans and matching PA radiographs. The distance from the crest of the ridge to the floor of the maxillary sinus or to the superior border of the inferior alveolar canal was measured. PAs were measured with Dexis software v.8.0 (DEXIS LLC, Des Plaines, IL) and CTs were measured with Simplant software v.11.02 (Materialise Dental Inc., Glen Burnie, MD). Two examiners (RJ and MM) recorded the measurements separately; each examiner recorded two readings. The average of the 4 readings was used for data analysis.Results: Absolute agreement: Paired t-test comparing ridge-height measurements between the two imaging methods showed no differences for maxillary sites (p>0.2) and significant differences for the mandibular sites (CT > PA, p = 0.0009). Relative agreement: Kendall rank correlation analysis of ridge-height measurements between the two imaging methods showed a high positive correlation for maxillary sites (Kendall's tau = 0.76, p = 0.0001) and moderate correlation for the mandibular sites (Kendall's tau = 0.46, p = 0.001).Conclusions: Maxillary PAs tend to approximate CT ridge-height measurements. By contrast mandibular PAs tend to underestimate the distance from the crest of the ridge to the inferior alveolar canal.

Juluri R; Moran M; Suzuki J; Khocht A

2013-01-01

268

The bone lamina technique: a novel approach for lateral ridge augmentation--a case series.  

UK PubMed Central (United Kingdom)

The goal of this case series is to present a novel treatment approach for lateral ridge augmentation. Four systemically healthy patients (aged 48 to 59 years) with inadequate dental alveolar ridge widths were selected for inclusion. All ridge defects were augmented using a xenogeneic cortical bone shield in combination with particulated bone substitutes and a thin collagen barrier. At baseline and after 6 months, digital cone beam computed tomography scans were performed. Biopsy specimens were harvested at reentry surgery and processed for histologic analysis. The results revealed a sufficient amount of bone structure for implant placement without additional augmentation procedures. The histologic analysis demonstrated that new bone formation had taken place and the bone shield had resorbed entirely. This case series indicates that the bone lamina technique has the biologic and mechanical properties to successfully achieve hard tissue augmentation of deficient ridges.

Wachtel H; Fickl S; Hinze M; Bolz W; Thalmair T

2013-07-01

269

The bone lamina technique: a novel approach for lateral ridge augmentation--a case series.  

Science.gov (United States)

The goal of this case series is to present a novel treatment approach for lateral ridge augmentation. Four systemically healthy patients (aged 48 to 59 years) with inadequate dental alveolar ridge widths were selected for inclusion. All ridge defects were augmented using a xenogeneic cortical bone shield in combination with particulated bone substitutes and a thin collagen barrier. At baseline and after 6 months, digital cone beam computed tomography scans were performed. Biopsy specimens were harvested at reentry surgery and processed for histologic analysis. The results revealed a sufficient amount of bone structure for implant placement without additional augmentation procedures. The histologic analysis demonstrated that new bone formation had taken place and the bone shield had resorbed entirely. This case series indicates that the bone lamina technique has the biologic and mechanical properties to successfully achieve hard tissue augmentation of deficient ridges. PMID:23820709

Wachtel, Hannes; Fickl, Stefan; Hinze, Marc; Bolz, Wolfgang; Thalmair, Tobias

270

Em busca de uma causa à parte da Ortodontia: hereditariedade e reabsorção apical em pacientes tratados ortodonticamente. Uma análise crítica do trabalho de Harris, Kineret e Tolley/ In search of a cause apart of Orthodontics: heredity and apical resorption in patients treated Orthodontically. A critical analysis of Harris, Kineret, Tolley?s work  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese Exclusivamente a partir da equivalência radiográfica do padrão e intensidade de reabsorção dentária em tratamento ortodôntico de 103 irmãos, Harris, Kineret e Tolley12 tentaram impingir um caráter hereditário a este fenômeno sem considerar a morfologia dentária e maxilar, nem tampouco outros fatores envolvidos na etiopatogenia das reabsorções. No trabalho fica claro que entre os objetivos principais dos autores estava atribuir à hereditariedade a ocorrênci (more) a de reabsorções dentárias durante o tratamento ortodôntico para aliviar em parte as responsabilidades profissionais perante os pacientes e a sociedade. Mas nos parece mais lógico que o profissional devesse habilitar-se para fazer a previsibilidade das reabsorções dentárias com base em seus planejamentos, considerando a morfologia radicular, o tipo de ápice dentário, a proporção coroa-raiz e a morfologia da crista óssea alveolar, bem como evitando escolher, sempre que possível, os procedimentos que mais usualmente estão associados à reabsorção radicular. Se o paciente apresentar-se com morfologias desfavoráveis e ainda assim necessitar de procedimentos associados a um maior risco de reabsorção em seu tratamento, que o mesmo seja informado e conscientizado que as reabsorções dentárias apicais serão um custo biológico para a recuperação de sua estética e função. Considerando: 1) a grande limitação proporcionada pelo diagnóstico de reabsorções apicais em radiografias panorâmicas e telerradiografias em norma lateral (cefalométricas); 2) a ausência de análise da morfologia dentária e da crista óssea alveolar; e 3) principalmente a falta de um grupo controle para comparar se os resultados seriam equivalentes, ou não, em uma população semelhante, sem qualquer parentesco, mas com as mesmas características dentomaxilares; pode-se afirmar que as conclusões do trabalho estão severamente comprometidas em sua credibilidade científica. Tanto a abordagem empregada na discussão quanto as conclusões obtidas pelos autores, sobre correlação entre genótipo, fenótipo e reabsorção dentária, parecem despropositadas, pois não houve estudos envolvendo células, nem tampouco uma metodologia de identificação de genes ou aplicação de qualquer técnica cujos resultados permitissem inferências desta natureza. Abstract in english Harris, Kineret, Tolley12 tried to implicate heritability to root resorption exclusively though radiographic equivalence between the pattern of resorption intensity after orthodontic treatment in 103 siblings. Neither dental nor facial morphology or any other etiopathogenic factor of root resorption was considered, whatsoever.It is clear in this study that the authors´ main goal was to attribute root resorption during orthodontic treatment to heritability in order to lig (more) hten the professional?s share of responsibility before patients and society. It seems more logic that the professional should try to predict root resorption when considering on treatment plan the root and alveolar crest morphology, the type of apex, crown-root proportion, and avoiding procedures known to cause more resorption. If a patient presents unfavorable morphology and still needs procedures associated with a higher risk of resorption, than he or she must be warned and informed that apical root resorption will be a biological cost to regain estetics and function. Considering on this paper: (1) the limitations to evaluate apical resorption in panoramic and cephalometric radiographs; (2) the absence of dental and alveolar crest morphology analysis; and (3) the lack of a control group in order to compare if the results would be equivalent in a similar population with no family ties but with same maxilofacial conditions; one can affirm that the scientific credibility of the conclusions are severely damaged. The conclusions drawn by the authors about genotype and phenotype concerning root resorption seem unfounded, since there was no cell analysis or gene identification

Consolaro, Alberto; Martins-Ortiz, Maria Fernanda

2004-05-01

271

Em busca de uma causa à parte da Ortodontia: hereditariedade e reabsorção apical em pacientes tratados ortodonticamente. Uma análise crítica do trabalho de Harris, Kineret e Tolley In search of a cause apart of Orthodontics: heredity and apical resorption in patients treated Orthodontically. A critical analysis of Harris, Kineret, Tolley’s work  

Directory of Open Access Journals (Sweden)

Full Text Available Exclusivamente a partir da equivalência radiográfica do padrão e intensidade de reabsorção dentária em tratamento ortodôntico de 103 irmãos, Harris, Kineret e Tolley12 tentaram impingir um caráter hereditário a este fenômeno sem considerar a morfologia dentária e maxilar, nem tampouco outros fatores envolvidos na etiopatogenia das reabsorções. No trabalho fica claro que entre os objetivos principais dos autores estava atribuir à hereditariedade a ocorrência de reabsorções dentárias durante o tratamento ortodôntico para aliviar em parte as responsabilidades profissionais perante os pacientes e a sociedade. Mas nos parece mais lógico que o profissional devesse habilitar-se para fazer a previsibilidade das reabsorções dentárias com base em seus planejamentos, considerando a morfologia radicular, o tipo de ápice dentário, a proporção coroa-raiz e a morfologia da crista óssea alveolar, bem como evitando escolher, sempre que possível, os procedimentos que mais usualmente estão associados à reabsorção radicular. Se o paciente apresentar-se com morfologias desfavoráveis e ainda assim necessitar de procedimentos associados a um maior risco de reabsorção em seu tratamento, que o mesmo seja informado e conscientizado que as reabsorções dentárias apicais serão um custo biológico para a recuperação de sua estética e função. Considerando: 1) a grande limitação proporcionada pelo diagnóstico de reabsorções apicais em radiografias panorâmicas e telerradiografias em norma lateral (cefalométricas); 2) a ausência de análise da morfologia dentária e da crista óssea alveolar; e 3) principalmente a falta de um grupo controle para comparar se os resultados seriam equivalentes, ou não, em uma população semelhante, sem qualquer parentesco, mas com as mesmas características dentomaxilares; pode-se afirmar que as conclusões do trabalho estão severamente comprometidas em sua credibilidade científica. Tanto a abordagem empregada na discussão quanto as conclusões obtidas pelos autores, sobre correlação entre genótipo, fenótipo e reabsorção dentária, parecem despropositadas, pois não houve estudos envolvendo células, nem tampouco uma metodologia de identificação de genes ou aplicação de qualquer técnica cujos resultados permitissem inferências desta natureza.Harris, Kineret, Tolley12 tried to implicate heritability to root resorption exclusively though radiographic equivalence between the pattern of resorption intensity after orthodontic treatment in 103 siblings. Neither dental nor facial morphology or any other etiopathogenic factor of root resorption was considered, whatsoever.It is clear in this study that the authors´ main goal was to attribute root resorption during orthodontic treatment to heritability in order to lighten the professional’s share of responsibility before patients and society. It seems more logic that the professional should try to predict root resorption when considering on treatment plan the root and alveolar crest morphology, the type of apex, crown-root proportion, and avoiding procedures known to cause more resorption. If a patient presents unfavorable morphology and still needs procedures associated with a higher risk of resorption, than he or she must be warned and informed that apical root resorption will be a biological cost to regain estetics and function. Considering on this paper: (1) the limitations to evaluate apical resorption in panoramic and cephalometric radiographs; (2) the absence of dental and alveolar crest morphology analysis; and (3) the lack of a control group in order to compare if the results would be equivalent in a similar population with no family ties but with same maxilofacial conditions; one can affirm that the scientific credibility of the conclusions are severely damaged. The conclusions drawn by the authors about genotype and phenotype concerning root resorption seem unfounded, since there was no cell analysis or gene identification method to permit such inferences.

Alberto Consolaro; Maria Fernanda Martins-Ortiz

2004-01-01

272

A new device for alveolar bone transportation.  

UK PubMed Central (United Kingdom)

We present a retrospective review of a new technique for the transportation of alveolar bone using a Hyrax device modified by the principal author (O.A.V.). There were seven patients (five males and two females), including five patients with cleft palate and lip diagnosis, one patient with a high-speed gunshot wound, and one patient with facial trauma sequel due to mandibular fracture. They were all treated with an alveolar bone transportation technique (ABT) through the use of the modified Hyrax device (VEGAX). Before surgery, distraction osteogenesis of the bifocal type was performed on four patients, and the trifocal type was performed on the other three patients. However, in one case, direct dental anchorage was not used, only orthodontic appliances. In all the cases, new bone formation and gingival tissue around the defect were obtained, posterior to the alveolar distraction process; no complications were observed in any patient. In one case, two teeth involved in the disk of the ABT were extracted, due to a previous condition of periodontal disease. The alveolar bone transport with the VEGAX device is an accessible technique for almost every patient with alveolar defects due to diverse causes. In all the presented cases, predictability and success were demonstrated.

Vega O; Pérez D; Páramo V; Falcón J

2011-06-01

273

Conservative management of progressive external inflammatory root resorption after traumatic tooth intrusion.  

UK PubMed Central (United Kingdom)

Intrusive luxation is one of the most severe types of dental trauma. The risk of development of inflammatory or replacement root resorption is high if not timely managed. Endodontic intervention is required soon after the occurrence of trauma, in an attempt to prevent or delay inflammatory root resorption. This case report emphasized timely referral for endodontic management of intruded tooth to prevent inflammatory root resorption.

Ghafoor R

2013-05-01

274

Dynamics of orthodontic root resorption and repair in human premolars: a light microscopy study.  

Science.gov (United States)

The purpose of the study was to investigate the relationship between root resorption and repair in human premolars that had been orthodontically intruded. The objective was to examine these processes related to time and root development. Seventy-six premolars were divided into subgroups: 33 teeth were intruded and then extracted (G1); 25 teeth were intruded and then left in situ for varying periods before extraction (G2); 18 teeth served as the controls (G3). All teeth were examined by light microscopy. Using non-parametric statistical analysis, differences between the groups were examined with the Pearson chi-square test. Teeth in G1 and G2 had significantly more resorptive lesions, 55 and 64 per cent, respectively, than the controls of 11 per cent. Resorption was observed over the whole root surface and increased with time. The occurrence increased to 100 per cent in both experimental groups after 36 days of intrusion. The appearance of lesions in relation to root development showed no differences between G1 and G2. In the apical part of the root, total resorption of the dentine was sometimes observed, but no resorptions extended into the predentine. Resorptive lesions undergoing repair were seen in both groups, with significantly more repair in G2 (58 per cent) than in G1 (32 per cent). Active resorption and repair were sometimes seen at the same resorption site. Deposition of cellular and acellular cementum was found to the same extent over the whole root when repair took place. With time, resorption appeared over the whole root surface. In some teeth, resorptive activity continued up to 10 days after removal of forces but on the other hand, repair of the resorbed area sometimes started during active movement. The individual variation in repair was much wider compared with resorption. The predentine layer in the apical area appeared not to be affected by the resorptive process. PMID:19465737

Winter, Björn U; Stenvik, Arild; Vandevska-Radunovic, Vaska

2009-05-22

275

Dynamics of orthodontic root resorption and repair in human premolars: a light microscopy study.  

UK PubMed Central (United Kingdom)

The purpose of the study was to investigate the relationship between root resorption and repair in human premolars that had been orthodontically intruded. The objective was to examine these processes related to time and root development. Seventy-six premolars were divided into subgroups: 33 teeth were intruded and then extracted (G1); 25 teeth were intruded and then left in situ for varying periods before extraction (G2); 18 teeth served as the controls (G3). All teeth were examined by light microscopy. Using non-parametric statistical analysis, differences between the groups were examined with the Pearson chi-square test. Teeth in G1 and G2 had significantly more resorptive lesions, 55 and 64 per cent, respectively, than the controls of 11 per cent. Resorption was observed over the whole root surface and increased with time. The occurrence increased to 100 per cent in both experimental groups after 36 days of intrusion. The appearance of lesions in relation to root development showed no differences between G1 and G2. In the apical part of the root, total resorption of the dentine was sometimes observed, but no resorptions extended into the predentine. Resorptive lesions undergoing repair were seen in both groups, with significantly more repair in G2 (58 per cent) than in G1 (32 per cent). Active resorption and repair were sometimes seen at the same resorption site. Deposition of cellular and acellular cementum was found to the same extent over the whole root when repair took place. With time, resorption appeared over the whole root surface. In some teeth, resorptive activity continued up to 10 days after removal of forces but on the other hand, repair of the resorbed area sometimes started during active movement. The individual variation in repair was much wider compared with resorption. The predentine layer in the apical area appeared not to be affected by the resorptive process.

Winter BU; Stenvik A; Vandevska-Radunovic V

2009-08-01

276

Toxicity of metallic ions in the lung: effects of alveolar macrophages and alveolar type II cells  

Energy Technology Data Exchange (ETDEWEB)

Airborne metallic particulates are associated with fossil-fueled power plants, automobile exhausts, metal mining, and metallurgical smelters. Therefore, the possible toxic effects of metals on the lung are of environmental and occupational concern. In this investigation the effects of in vitro exposure to metallic ions on the following parameters were determined: oxygen consumption and membrane integrity of alveolar macrophages and type II cells, and chemiluminescence of zymosan-stimulated alveolar macrophages. Cu/sup 2 +/ and Zn/sup 2 +/ exhibited marked toxicity to isolated alveolar macrophages and type II cells, while V/sup 3 +/ exhibited intermediate toxicity. In contrast, short-term in vitro exposure to As/sup 5 +/ and Se/sup 4 +/ had little effect on alveolar macrophages and type II cells. Although the data suggest that exposure to certain metals may be harmful to the lung, the various pulmonary parameters tested in this investigation displsay differing susceptibility to metal exposure. That is, metals are less toxic to alveolar type II cells than to alveolar macrophages. Our data also indicate that chemiluminescence is the most sensitive assay for monitoring the viability of alveolar macrophages, while oxygen consumption is a sensitive assay for type II cells. 34 references, 3 figures, 4 tables.

Castranova, V.; Bowman, L.; Wright, J.R.; Colby, H.; Miles, P.R.

1984-01-01

277

[Autoimmunological pulmonary alveolar proteinosis--case report].  

UK PubMed Central (United Kingdom)

Autoimmunological pulmonary alveolar proteinosis (APAP) is a rare interstitial lung disease with abnormal surfactant homeostasis. Autoimmunological pulmonary alveolar proteinosis is diagnosed most often in the third or fourth decade of life. Predominant symptoms are dyspnea and cough. In most cases, disease is mild but in more severe cases when dyspnea limits patient physical activity a treatment is required. The most common treatment procedure is a whole-lung lavage. We present a case study of 37 years old woman with the patchy consolidations in the chest radiograph. High resolution computed tomography (HRCT) image suggested hipersensivity pneumonitis. At the beginning due to limited disease symptoms no specific proceedings was implemented. After two year follow-up of non-resolving pulmonary changes the decision about open lung biopsy was made. On the basis of histological examination of samples and presence of anty GM-CSF antibodies the diagnosis of autoimmunological pulmonary alveolar proteinosis was established.

Stok?osa A; Radzikowska E; Bara?ska I; Langfort R; Nowi?ski A; Kami?ski D; Górecka D

2012-01-01

278

Whole lung lavage for pulmonary alveolar proteinosis  

Directory of Open Access Journals (Sweden)

Full Text Available A 26-year-old male presented with complaints of dry cough of six months and progressive breathlessness of three months duration. He was coughing out milky white sputum for two months and had lost 12 kg weight in two months. He had an evening rise in temperature of one month duration. Clinically, the patient was in respiratory distress and the respiratory system examination revealed bilateral velcro crackles. High resolution computed tomography chest showed bilateral diffuse reticulonodular opacities and "Crazy Paving" pattern suggestive of alveolar proteinosis. Broncho alveolar lavage showed eosinophilic granular material, which was periodic acid-Schiff positive. Open lung biopsy was done to confirm the diagnosis and the histopathologic examination revealed eosinophilic secretions with granular appearance suggestive of pulmonary alveolar proteinosis. Subsequently, patient underwent bilateral sequential whole lung lavage under general anesthesia. Patient showed marked clinical and radiological improvement after sequential whole lung lavage.

Jayaraman S; Gayathri A; Kumar P; Santosham Rajeev; Santosham Rajan; Narasimhan R

2010-01-01

279

Oxidant Injury to the Alveolar Epithelium: Biochemical and Pharmacologic Studies.  

Science.gov (United States)

The study combined biochemical and cellular analyses of oxidant metabolism by a lung cell at risk from injury by endogenous and environmental oxidants, the pulmonary alveolar type II epithelial cell. Because alveolar epithelial cells are recognized as sen...

B. A. Freeman P. C. Panus S. Matalon B. J. Buckley R. R. Baker

1993-01-01

280

Increased alveolar plasminogen activator in early asbestosis  

Energy Technology Data Exchange (ETDEWEB)

Alveolar macrophage-derived plasminogen activator (PA) activity is decreased in some chronic interstitial lung diseases such as idiopathic pulmonary fibrosis and sarcoidosis but increased in experimental models of acute alveolitis. Although asbestos fibers can stimulate alveolar macrophages (AM) to release PA in vitro, the effect of chronic asbestos exposure of the lower respiratory tract on lung PA activity remains unknown. The present study was designed to evaluate PA activity of alveolar macrophages and bronchoalveolar lavage (BAL) fluid in asbestos-exposed sheep and asbestos workers. Forty-three sheep were exposed to either 100 mg UICC chrysotile B asbestos in 100 ml phosphate-buffered saline (PBS) or to 100 ml PBS by tracheal infusion every 2 wk for 18 months. At Month 18, chest roentgenograms were analyzed and alveolar macrophage and extracellular fluid PA activity were measured in samples obtained by BAL. Alveolar macrophage PA activity was increased in the asbestos-exposed sheep compared to control sheep (87.2 +/- 17.3 versus 41.1 +/- 7.2 U/10(5) AM-24 h, p less than 0.05) as was the BAL fluid PA activity (674.9 +/- 168.4 versus 81.3 +/- 19.7 U/mg alb-24 h, p less than 0.01). Among the asbestos-exposed sheep, 10 had normal chest roentgenograms (Group SA) and 15 had irregular interstitial opacities (Group SB). Strikingly, whereas Group SA did not differ from the control group in BAL cellularity or PA activity, Group SB had marked increases in alveolar macrophages (p less than 0.005), AM PA activity (p less than 0.02), and BAL PA activity (p less than 0.001) compared to the control group.

Cantin, A.; Allard, C.; Begin, R.

1989-03-01

 
 
 
 
281

Descrição fonética eletropalatográfica de fones alveolares/ Phonetic description of alveolar phones using electropalatography  

Scientific Electronic Library Online (English)

Full Text Available Abstract in portuguese OBJETIVO: Realizar a descrição articulatória do Português Brasileiro, examinando-se o contato da língua com o palato na produção de fones consonantais. MÉTODOS: Foi utilizada a eletropalatografia (EPG) de consoantes alveolares do Português Brasileiro de um sujeito com fala típica, considerando-se o índice alveolar, pós-alveolar, palatal e velar e a porcentagem de contatos ativados no ponto de máxima constrição, assim como a inspeção visual dos palatograma (more) s. RESULTADOS: Observou-se, conforme o esperado, que todos os fones avaliados têm, no ponto de máxima constrição, maior contato na região alveolar. Os fones /t/, /d/ e /n/ foram os que apresentaram maior contato alveolar, com obstrução total da corrente aérea; os fones fricativos /s/ e /z/ caracterizaram-se pela ausência de contato no eixo longitudinal central; o fone lateral /l/ não apresentou contato no eixo longitudinal lateral e o tapa, /?/, apresentou poucos contatos da língua com o palato e foi produzido com o menor tempo de duração. CONCLUSÃO: Por meio da eletropalatografia, pode-se fazer uma descrição detalhada da forma e da extensão do contato língua-palato nos diferentes fones alveolares do Português. Abstract in english PURPOSE: To describe the articulation of the Brazilian Portuguese, by examining the tongue-palate contact in the production of consonantal phones. METHODS: The electropalatography (EPG) of the alveolar consonants of the Brazilian Portuguese produced by an individual with typical speech was used, considering the alveolar, post-alveolar, palatal, and velar rates, as well as the percentage of activated contacts at the point of maximum constriction, and the visual inspection (more) of palatograms. RESULTS: As expected, it was observed that all the examined phones have more contact in the alveolar region at the point of maximum constriction. The phones /t/, /d/ and /n/ showed more alveolar contact, with total obstruction of the air stream; the fricative phones /s/ and /z/ were characterized by the absence of contact at the central longitudinal axis; the lateral phone /l/ did not present contact at the lateral longitudinal axis, and the tap /?/ showed not only few tongue-palate contacts but it was also produced in the shortest duration time. CONCLUSION: The electopalatography allowed a detailed description of the extension of the tongue-palate contact in the different alveolar phones of the Brazilian Portuguese and how they occur.

Jesus, Marisa de Sousa Viana; Reis, Cesar

2012-01-01

282

[Comparative studies of amoxicillin resorption and distribution in poultry  

UK PubMed Central (United Kingdom)

Comparative experiments were carried out to test the resorption and retention of amoxicillin-trihydrate, ampicillin-trihydrate and amopen-powder Pharmachim drug formula (containing 5 per cent amoxicillin-trihydrate) following a single oral application to chickens and wild ducks. Higher was the resorption of amoxicillin as a trihydrate in comparison to ampicillin as trihydrate (it provides concentrations twice as high in the blood of chickens). The ducks were found to utilize amoxicillin as trihydrate in a similar manner, however, they excrete it more rapidly. The distribution of the preparation was determined in the viscera of chickens treated with amoxicillin via the feed at the rate of 20.0 /kg feed in the course of six days. It was found that amoxicillin was retained in therapeutic concentrations in the liver, kidneys, lungs, and muscles, and in lower concentrations in the spleen and heart. It was established that the brain also contained negligible amounts of the preparation. The tissue concentrations did not surpass the serum ones.

Lashev L; Semerdzhiev V

1983-01-01

283

Hyperbaric oxygen therapy suppresses osteoclast formation and bone resorption.  

UK PubMed Central (United Kingdom)

The cellular and molecular mechanism through which hyperbaric oxygen therapy (HBO) improves osteonecrosis (ON) is unclear. The present study therefore examined the effect of HBO, pressure and hyperoxia on RANKL-induced osteoclast formation in RAW 264.7 cells and human peripheral blood monocytes (PBMC). Daily exposure to HBO (2.4 ATA, 97% O2 , 90?min), hyperbaric pressure (2.4 ATA, 8.8% O2 , 90?min) or normobaric hyperoxia (1 ATA, 95% O2 , 90?min) significantly decreased RANKL-induced osteoclast formation and bone resorption in normoxic conditions. HBO had a more pronounced anti-osteoclastic effect than hyperoxia or pressure alone and also directly inhibited osteoclast formation and resorption in hypoxic conditions a hallmark of many osteolytic skeletal disorders. The suppressive action of HBO was at least in part mediated through a reduction in RANK, NFATc1, and Dc-STAMP expression and inhibition of hypoxia-induced HIF-1? mRNA and protein expression. This data provides mechanistic evidence supporting the use of HBO as an adjunctive therapy to prevent osteoclast formation and bone loss associated with low oxygen partial pressure. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

Hadi HA; Smerdon GR; Fox SW

2013-07-01

284

A resorption refrigerator driven by low grade thermal energy  

International Nuclear Information System (INIS)

Highlights: ? A resorption refrigerator employing MnCl2-NH3 and NH4Cl-NH3 was designed and investigated. ? The experiments were operated under different ambient temperatures from 20 to 35 oC. ? The refrigerator provided simultaneously two cooling levels: at 0-6 oC and at -16 ? -14.5 oC. ? With 3 h operation the total cooling capacity was 475 kJ per kg of NH4Cl salt. ? The effective cooling production was 25-42% of the total cooling capacity. -- Abstract: A small refrigerator based on resorption technique, employed MnCl2 and NH4Cl as sorbent salts and ammonia as refrigerant, was presented for simultaneously cooling at 0-6 oC and freezing at -16 to -14.5 oC in this work. The cooling capacity of this device was investigated by measuring the mass amount of the ice generated during a certain period of 3 h operation, and the experiments were conducted at different ambient temperature ranging from 20 oC to 35 oC. The total cooling capacity was calculated 475 kJ per kg of NH4Cl salt, and the mean specific cooling power (SCP) was 43 W per kg of NH4Cl salt, the effective cooling production responsible for making ice accounted for 25-42% of the total cooling capacity depending on the different operating conditions studied in this work.

2002-01-00

285

Hyperbaric oxygen therapy suppresses osteoclast formation and bone resorption.  

Science.gov (United States)

The cellular and molecular mechanism through which hyperbaric oxygen therapy (HBO) improves osteonecrosis (ON) is unclear. The present study therefore examined the effect of HBO, pressure and hyperoxia on RANKL-induced osteoclast formation in RAW 264.7 cells and human peripheral blood monocytes (PBMC). Daily exposure to HBO (2.4 ATA, 97% O2 , 90?min), hyperbaric pressure (2.4 ATA, 8.8% O2 , 90?min) or normobaric hyperoxia (1 ATA, 95% O2 , 90?min) significantly decreased RANKL-induced osteoclast formation and bone resorption in normoxic conditions. HBO had a more pronounced anti-osteoclastic effect than hyperoxia or pressure alone and also directly inhibited osteoclast formation and resorption in hypoxic conditions a hallmark of many osteolytic skeletal disorders. The suppressive action of HBO was at least in part mediated through a reduction in RANK, NFATc1, and Dc-STAMP expression and inhibition of hypoxia-induced HIF-1? mRNA and protein expression. This data provides mechanistic evidence supporting the use of HBO as an adjunctive therapy to prevent osteoclast formation and bone loss associated with low oxygen partial pressure. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1839-1844, 2013. PMID:23878004

Hadi, Hadil Al; Smerdon, Gary R; Fox, Simon W

2013-07-22

286

Evaluation of the posterior superior alveolar artery and the maxillary sinus with CBCT.  

UK PubMed Central (United Kingdom)

Assessment of the maxillary sinus anatomy before sinus augmentation is important for avoiding surgical complications, because of the close anatomical relationship between the posterior maxillary teeth and the maxillary sinus. The posterior superior alveolar artery (PSAA) is the branch of the maxillary artery that supplies the lateral sinus wall and overlying membrane. We evaluated the location of the PSAA and its relationship to the alveolar ridge and maxillary sinus using cone beam computed tomography (CBCT). The study group consisted of 135 CBCT scans (270 sinuses) obtained from the archive of the dentomaxillofacial radiology department at Yeditepe University Faculty of Dentistry, Istanbul, Turkey. The distance between the lower border of the artery and the alveolar crest, bone height from the sinus floor to the ridge crest, distance from the artery to the medial sinus wall, and the diameter and location of the artery were determined. The occurrence of septa and pathology were recorded from CBCT scans. The PSAA was observed in 89.3% of sinuses, and 71.1% of arteries were intraosseous with diameters mostly < 1 mm (68.9%). The prevalence of sinus septa was 55.2%, and that of sinus pathology was 57.4%. The mean age was 43.07 ± 17.55 years. There was a statistically significant difference between the location of the artery and gender (p < 0.05). The prevalence of sinus membrane thickening was 57.4%. Detailed knowledge about the location of the PSAA and sinus morphology may be obtained with CBCT before maxillary sinus surgery.

Ilgüy D; Ilgüy M; Dolekoglu S; Fisekcioglu E

2013-09-01

287

Evaluation of the posterior superior alveolar artery and the maxillary sinus with CBCT  

Scientific Electronic Library Online (English)

Full Text Available Abstract in english Assessment of the maxillary sinus anatomy before sinus augmentation is important for avoiding surgical complications, because of the close anatomical relationship between the posterior maxillary teeth and the maxillary sinus. The posterior superior alveolar artery (PSAA) is the branch of the maxillary artery that supplies the lateral sinus wall and overlying membrane. We evaluated the location of the PSAA and its relationship to the alveolar ridge and maxillary sinus usin (more) g cone beam computed tomography (CBCT). The study group consisted of 135 CBCT scans (270 sinuses) obtained from the archive of the dentomaxillofacial radiology department at Yeditepe University Faculty of Dentistry, Istanbul, Turkey. The distance between the lower border of the artery and the alveolar crest, bone height from the sinus floor to the ridge crest, distance from the artery to the medial sinus wall, and the diameter and location of the artery were determined. The occurrence of septa and pathology were recorded from CBCT scans. The PSAA was observed in 89.3% of sinuses, and 71.1% of arteries were intraosseous with diameters mostly < 1 mm (68.9%). The prevalence of sinus septa was 55.2%, and that of sinus pathology was 57.4%. The mean age was 43.07 ± 17.55 years. There was a statistically significant difference between the location of the artery and gender (p < 0.05). The prevalence of sinus membrane thickening was 57.4%. Detailed knowledge about the location of the PSAA and sinus morphology may be obtained with CBCT before maxillary sinus surgery.

Ilguy, Dilhan; Ilguy, Mehmet; Dolekoglu, Semanur; Fisekcioglu, Erdogan

2013-09-01

288

Plow and ridge nanofabrication.  

Science.gov (United States)

Traditionally, scanning probe lithography tools are limited in resolution by the radius of curvature of the tip used. Herein, an approach is described for patterning the ridge of piled-up polymer that naturally occurs when a scanning probe is pressed against a soft surface. The use of this phenomenon to transfer patterns to hard materials with 20 nm resolution is demonstrated. PMID:23427089

Shim, Wooyoung; Brown, Keith A; Zhou, Xiaozhu; Rasin, Boris; Liao, Xing; Schmucker, Abrin L; Mirkin, Chad A

2013-02-20

289

Plow and ridge nanofabrication.  

UK PubMed Central (United Kingdom)

Traditionally, scanning probe lithography tools are limited in resolution by the radius of curvature of the tip used. Herein, an approach is described for patterning the ridge of piled-up polymer that naturally occurs when a scanning probe is pressed against a soft surface. The use of this phenomenon to transfer patterns to hard materials with 20 nm resolution is demonstrated.

Shim W; Brown KA; Zhou X; Rasin B; Liao X; Schmucker AL; Mirkin CA

2013-09-01

290

Alveolar Gas - iPad App  

Science.gov (United States)

This app is for teaching the factors that affect the composition of ÃÂAlveolar GasÃÂ. A student or instructor can manipulate variables like tidal volume, dead space, and the oxygen consumption rate and see how they affect alveolar PO2 and PCO2. The app is suitable for use either as a classroom demonstration or self-instruction.

2012-08-23

291

PREVENTION AND TREATMENT OF ALVEOLAR OSTEITIS  

UK PubMed Central (United Kingdom)

A tissue adhesive antimicrobial material that is placed into a tooth extraction site for the sustained release of silver for the prevention and treatment of alveolar osteitis. The antimicrobial material is placed into a tooth extraction site via syringe, hand instrument or hand delivery device.

BLOCK JAMES C; JERNBERG GARY R

292

Albendazole and alveolar disease: A case report  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Hydatidsis is a zoonosis transmitted by domestic and wild animals. Two distinct clinical presentations are as followes: unilocular of cystic hydatid disease and the more malignant form, called alveolar hydatid disease.This case report presents a patient who complained of chest pain and hemoptysis an...

Daneshjou Kh; Haghshenas Z

293

The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits.  

UK PubMed Central (United Kingdom)

Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference? In contrast with other antiresorptives, such as alendronate (ALN), ODN targets only the very last step of the resorption process. We hypothesize that ODN may therefore modify the remodeling events immediately following osteoclastic resorption. These events belong to the reversal phase and include recruitment of osteoblasts, which is critical for connecting bone resorption to formation. We performed a histomorphometric study of trabecular remodeling in vertebrae of estrogen-deficient rabbits treated or not with ODN or ALN, a model where ODN, but not ALN, was previously shown to preserve bone formation. In line with our hypothesis, we found that ODN treatment compared to ALN results in a shorter reversal phase, faster initiation of osteoid deposition on the eroded surfaces, and higher osteoblast recruitment. The latter is reflected by higher densities of mature bone forming osteoblasts and an increased subpopulation of cuboidal osteoblasts. Furthermore, we found an increase in the interface between osteoclasts and surrounding osteoblast-lineage cells. This increase is expected to favor the osteoclast-osteoblast interactions required for bone formation. Regarding bone resorption itself, we show that ODN, but not ALN, treatment results in shallower resorption lacunae, a geometry favoring bone stiffness. We conclude that, compared to standard antiresorptives, ODN shows distinctive effects on resorption geometry and on reversal phase activities which positively affect osteoblast recruitment and may therefore favor bone formation.

Jensen PR; Andersen TL; Pennypacker BL; Duong LT; Delaissé JM

2013-10-01

294

Bone formation and resorption are both increased in experimental autoimmune arthritis  

DEFF Research Database (Denmark)

Arthritic bone loss in the joints of patients with rheumatoid arthritis is the result of a combination of osteoclastic bone resorption and osteoblastic bone formation. This process is not completely understood, and especially the importance of local inflammation needs further investigation. We evaluated how bone formation and bone resorption are altered in experimental autoimmune arthritis.

Keller, Kresten Krarup; Thomsen, Jesper Skovhus

2012-01-01

295

Orthodontic treatment and root resorption of teeth: Critical analysis of mechanical factors.  

Directory of Open Access Journals (Sweden)

Full Text Available AIM: The aim of this review is the presentation and critical analysis of the mechanical factors associated with orthodontic treatment and implicated in the formation of root resorption.METHOD: Original articles and reviews pertaining to this topic were searched at the data base PubMed until May 2009.FINDINGS: Root resorption shows considerable variations. Individuals may present minimal or significant resorption, more than 3 mm while a percentage of 5% may present more than 5 mm. The magnitude of forces applied by the orthodontist seems to be among the mechanical factors that may affect the formation of resorptions, while intrusion and jiggling seem to be the most harmful among the teeth movement types. Teeth resorptions also seem to be associated with the type and duration of the applied forces, the range of tooth movement, as well as with genetic and biological factors, rendering this way the dissociation and the degree of participation of these factors in the appearance of resorptions particularly difficult.CONCLUSIONS: Root resorptions of teeth are an unanticipated phenomenon of multifactorial etiology. Up until now, it seems that there is not enough evidence that could lead to specific strategies efficient to minimize or prevent the phenomenon of root resorption.

Ioulia Ioannidou-Marathiotou; Moshos A. Papadopoulos

2010-01-01

296

Maxillary bone transportation in alveolar cleft-transport distraction osteogenesis for treatment of alveolar cleft repair.  

Science.gov (United States)

Secondary autogenous cancellous bone grafting is a widely used method for the treatment of alveolar clefts and oronasal fistulae. However, failure of iliac bone grafting sometimes occurs due to inadequate covering with the surrounding soft tissue and marked scar formation, inappropriate patient age, or large clefts. For alveolar clefts, we developed a method consisting of alveolar bone transportation, closure of the alveolar cleft, and/or grafting of new bone. Transport distraction osteogenesis along the curve of the dental arch is ideal. Alveolar bone was transported in the planned direction using a ready-made bone-borne distractor in combination with an orthodontic arch wire for transport guidance. This method allows simultaneous correction of nasal septal deviation and also correction of maxillary arch deformities and malocclusion since, the dental arch is expanded without donor sacrifice. This method can be regarded as tissue engineering to expand bone tissue. This method can be safely performed not only in patients undergoing initial treatment for alveolar clefts but also in patients in whom bone grafting has failed. Since 1997, we have performed this method in 22 patients and obtained good results. PMID:15927149

Mitsugi, Masaharu; Ito, Osamu; Alcalde, Rafael E

2005-07-01

297

[Intra-alveolar hemorrhage associated with dengue and leptospirosis].  

UK PubMed Central (United Kingdom)

The intra-alveolar hemorrhage syndrome is defined by the presence of red cells in the alveolar lumen and can lead to acute respiratory failure. Among the infectious etiologies of this syndrome, leptospirosis is a common cause, whereas in dengue, the intra-alveolar hemorrhage is exceptional. We report a patient aged 46 years, with no particular history, who presented a clinical picture involving acute respiratory failure, hemoptysis, bilateral alveolar images and anemia. The intra-alveolar hemorrhage has been authenticated by bronchoalveolar lavage. The etiological showed infection by both dengue and leptospirosis.

Cadélis G

2012-10-01

298

Chemical modulation of alveolar epithelial permeability  

Energy Technology Data Exchange (ETDEWEB)

The volume and composition of fluid on the surface of the alveoli can affect alveolar ventilation, gas diffusion, and macrophage function. The passive permeability and active processes of the alveolar epithelial lining play a role in regulating surface fluid and are a potential site of damage by airborne chemicals. Like other epithelial barriers, the alveolar lining is permeabile to lipophilic substances but restricts the transmural flow of small ions and hydrophilic nonelectrolytes (equivalent pore radius ca. 0.5 to 1.5 nm). The mammalian fetal lung and alveolar sacs of the adult bullfrog secrete Cl- and K+ into the airspace. Secretion by the fetal lung ceases at birth. Many environmental agents increase the permeability of the capillary endothelium and/or respiratory epithelium and induce pulmonary edema. Studies with bullfrog alveolar sacs have demonstrated that selective effects may or may not be followed by general derangement of the epithelial barrier. Exposure of the luminal surface to HgCl2 (10(-6) to 10(-4) M) induces a selective increase in Cl- secretion that is followed by a fall in transport and a general increase in ion permeation. CdC/sub 12/ (10(-5) to 10(-3) M) depresses ciliomotion on cells on the trabecula of the alveolus but does not affect Cl- secretion or transepithelial conductance. HNO/sub 3/, like other mineral acids, increases conductance and the radii or pores in the barrier, whereas NaNO/sub 3/ selectively inhibits Cl- secretion. Amphotericin B(10(7) to 10(-5) MJ) induces K+ secretion into the lumen of both bullfrog and rat lung. We conclude that environmental agents induce changes in epithelial function that may compromise the lung's ability to regulate respiratory fluid without destroying the characteristic permeability of the epithelial lining.

Gatzy, J.T.; Stutts, M.J.

1980-04-01

299

Fc receptor function on sheep alveolar macrophages.  

Science.gov (United States)

We have examined the binding to sheep alveolar macrophages (AM) and peripheral blood polymorphonuclear leukocytes (PMN) of sheep immunoglobulin G subclasses or rabbit IgG immune complexes formed between rabbit anti-DNP IgG and DNP-bovine serum albumin. Binding studies using 125I-rabbit IgG immune complexes demonstrated 6.6 +/- 3.5 X 10(4) receptors per alveolar macrophage; these receptors bound immune complexes with an average association constant of 3.3 X 10(7) M-1. Saturation binding was achieved by 90 minutes at 4 degrees C with 6 X 10(-8) M IgG. Binding of subclasses of sheep IgG was examined by immunofluorescence. Only 10% of alveolar macrophages bound monomeric IgG1 and no binding of sheep IgG2 monomer could be demonstrated. In contrast, most peripheral blood PMN (93.0 +/- 9.5%) bound IgG2, but not IgG1. No binding to adult peripheral blood PMN of rabbit IgG immune complexes could be demonstrated. To study further the development of pulmonary host defense, we examined the expression of receptors for IgG immune complexes (Fc gamma R) on alveolar macrophages obtained from animals aged 8 through 180 days. At 8 and 21 days of age, the number of Fc gamma R varied considerably (75,000-192,000 sites per cell) and equalled or even exceeded that of adult sheep. Fc gamma R number declined by 42 and 90 days of age, where a nadir was reached (37,000 +/- 6,000 and 25,000 +/- 6,000 sites, respectively). By 180 days of age, the number of receptors had approached those of normal adult sheep (70,000 +/- 20,000 sites per cell). These studies parallel previous observations that revealed age-related differences in the phagocytic capacity of ovine alveolar macrophages. PMID:3528365

Fleit, H B; Weiss, R A; Chanana, A D; Joel, D D

1986-10-01

300

Non-Surgical Repair of Internal Resorption with MTA: A Case Report.  

Science.gov (United States)

Internal resorption is rare in permanent teeth. Treatment is usually performed through warm gutta-percha technique. If the resorptive process perforates the root, treatment may be more difficult and is usually performed via surgical approach. Non-surgical repair of a perforating internal root resorption with MTA was conducted in this case. Before repairing the resorption, a master gutta-percha point was placed in the canal to maintain negotiability of the original canal path. Then, MTA was prepared and applied with a small carrier in the resorption area and compacted. Thereafter gutta-percha was retrieved and the access cavity was closed with a temporary filling material. In the second visit, the root canal was obturated with gutta-percha and AH26 sealer using lateral compaction technique and subsequently, the crown was restored. The symptoms and signs ceased and the result was satisfactory at the 18 month follow-up visit. PMID:23130082

Mohammadi, Zahed; Yazdizadeh, Mohammad; Shalavi, Sousan

2012-10-13

 
 
 
 
301

Non-Surgical Repair of Internal Resorption with MTA: A Case Report.  

UK PubMed Central (United Kingdom)

Internal resorption is rare in permanent teeth. Treatment is usually performed through warm gutta-percha technique. If the resorptive process perforates the root, treatment may be more difficult and is usually performed via surgical approach. Non-surgical repair of a perforating internal root resorption with MTA was conducted in this case. Before repairing the resorption, a master gutta-percha point was placed in the canal to maintain negotiability of the original canal path. Then, MTA was prepared and applied with a small carrier in the resorption area and compacted. Thereafter gutta-percha was retrieved and the access cavity was closed with a temporary filling material. In the second visit, the root canal was obturated with gutta-percha and AH26 sealer using lateral compaction technique and subsequently, the crown was restored. The symptoms and signs ceased and the result was satisfactory at the 18 month follow-up visit.

Mohammadi Z; Yazdizadeh M; Shalavi S

2012-01-01

302

Foliar Nutrient Dynamics and Foliar Resorption in Quercus brantii Lindley along an Elevational Gradient  

Directory of Open Access Journals (Sweden)

Full Text Available Foliar mass per area (mg dm-2) -based nitrogen and phosphorus concentrations, specific leaf mass (mg dm-2) and absolute and proportional resorption in Quercus brantii was investigated along a topographic gradient from 450 to 850 m altitude. Foliar N and P concentrations in Q. brantii exhibited significant differences with respect to topographic position and sampling dates in all of the studied parameters. A sharp decrease was observed from April to September in terms of Specific Leaf Mass (SLM) values. However, mass per area-based absolute and proportional N resorption was lowest at 450 m, while absolute and proportional P resorption was lowest at 850 m. Significant correlations were found between mass per area-based leaf nutrient concentration and foliar resorption except for the correlations between absolute P resorption and foliar P concentrations at 450, 650 and 750 m during full-leaf expansion and 850 m during senescence, respectively.

Ertugrul Aksekili; Dudu Duygu Kilic; Hamdi Guray Kutbay

2007-01-01

303

Non-Surgical Repair of Internal Resorption with MTA: A Case Report  

Directory of Open Access Journals (Sweden)

Full Text Available Internal resorption is rare in permanent teeth. Treatment is usually performed through warm gutta-percha technique. If the resorptive process perforates the root, treatment may be more difficult and is usually performed via surgical approach. Non-surgical repair of a perforating internal root resorption with MTA was conducted in this case. Before repairing the resorption, a master gutta-percha point was placed in the canal to maintain negotiability of the original canal path. Then, MTA was prepared and applied with a small carrier in the resorption area and compacted. Thereafter gutta-percha was retrieved and the access cavity was closed with a temporary filling material. In the second visit, the root canal was obturated with gutta-percha and AH26 sealer using lateral compaction technique and subsequently, the crown was restored. The symptoms and signs ceased and the result was satisfactory at the 18 month follow-up visit.

Zahed Mohammadi; Mohammad Yazdizadeh; Sousan Shalavi

2012-01-01

304

The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Udgivelsesdato: 2004-Jul , Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption withou...

Schaller, Sophie; Henriksen, Kim; Sveigaard, Christina; Heegaard, Anne-Marie; Hélix, Nathalie; Stahlhut, Martin

305

Risk variables of external apical root resorption during orthodontic treatment  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUCTION: External apical root resorption (EARR) is an adverse outcome of the orthodontic treatment. So far, no single or associated factor has been identified as responsible for EARR due to tooth movement. OBJECTIVE: This study investigated the association of risk variables (age, gender, extraction for orthodontic treatment and Angle classification) with EARR and orthodontic treatment. METHOD: The sample (n=72) was divided into two groups according to presence (n=32) or absence (n=40) of EARR in maxillary central and lateral incisors after orthodontic treatment. RESULTS: There were no statistically significant differences in EARR according to age, gender, extraction or type of malocclusion (p>0.05). CONCLUSION: The risk variables examined were not associated with EARR in the study population.

Maria Carolina Feio Barroso; Renan Lana Devita; Eugênio José Pereira Lages; Fernando de Oliveira Costa; Alexandre Fortes Drummond; Henrique Pretti; Elizabeth Maria Bastos Lages

2012-01-01

306

Quantification of condylar resorption in temporomandibular joint osteoarthritis.  

UK PubMed Central (United Kingdom)

OBJECTIVE: This study was performed to determine the condylar morphologic variation of osteoarthritic (OA) and asymptomatic temporomandibular joints (TMJs) and to determine its correlation with pain intensity and duration. STUDY DESIGN: Three-dimensional surface models of mandibular condyles were constructed from cone-beam computerized tomography images of 29 female patients with TMJ OA (Research Diagnostic Criteria for Temporomandibular Disorders group III) and 36 female asymptomatic subjects. Shape correspondence was used to localize and quantify the condylar morphology. Statistical analysis was performed with multivariate analysis of covariance analysis, using Hotelling T(2) metric based on covariance matrices, and Pearson correlation. RESULTS: The OA condylar morphology was statistically significantly different from the asymptomatic condyles (P < .05). Three-dimensional morphologic variation of the OA condyles was significantly correlated with pain intensity and duration. CONCLUSION: Three-dimensional quantification of condylar morphology revealed profound differences between OA and asymptomatic condyles, and the extent of the resorptive changes paralleled pain severity and duration.

Cevidanes LH; Hajati AK; Paniagua B; Lim PF; Walker DG; Palconet G; Nackley AG; Styner M; Ludlow JB; Zhu H; Phillips C

2010-07-01

307

CSF-1 induces resorption of embryos in mice.  

UK PubMed Central (United Kingdom)

We have shown previously that C57BL/6J female mice inoculated with the syngeneic BL6-T2 regressor tumor resorb a high proportion of embryos sired by B6D2F1 or DBA/2 males but not embryos engendered by CBA/J or C57BL/6J males. In this present report, we provide a mechanism elucidating the nature of the fetal wastage observed. It was found that the BL6-T2 tumor secretes constitutively GM-CSF and CSF-1. Based on the hypothesis that those cytokines could interfere with normal fetal development, we injected semi-purified GM-CSF or CSF-1 into pregnant females, for five days. Results show that CSF-1 was able to induce a high rate of fetal resorption whereas GM-CSF had no effect.

Tartakovsky B

1989-11-01

308

Revisiting the hopeless ridge: Part II--Inductive orthopedic allograft applied to dental implant regeneration.  

UK PubMed Central (United Kingdom)

Part I of "Revisiting the Hopeless Ridge" highlighted the higher complication rates, greater resorption profile, and lower implant success rates associated with autogenous block grafts. The conclusions described in that article were based on a comprehensive literature review, rather than an individual clinician's experience in clinical practice. Additionally, the idea that such grafts were the gold standard for traditional dental implant-associated bone regeneration was challenged. This article explores the advantageous properties of new commercially available allograft bone in a variety of clinical applications. One such product that combines demineralized bone with lecithin is reviewed, and two case reports using it are presented.

Lupovici J

2009-05-01

309

Resorption controls bone anabolism driven by PTH receptor signaling in osteocytes.  

UK PubMed Central (United Kingdom)

The contribution of remodeling-based bone formation coupled to osteoclast activity versus modeling-based bone formation that occurs independently of resorption, to the anabolic effect of PTH remains unclear. We addressed this question using transgenic mice with activated PTH receptor signaling in osteocytes that exhibit increased bone mass and remodeling, recognized skeletal effects of PTH elevation. Direct inhibition of bone formation was accomplished genetically by overexpressing the Wnt antagonist Sost/sclerostin; and resorption-dependent bone formation was inhibited pharmacologically with the bisphosphonate alendronate. We found that bone formation induced by osteocytic PTH receptor signaling on the periosteal surface depends on Wnt signaling but not on resorption. In contrast, bone formation on the endocortical surface results from a combination of Wnt-driven increased osteoblast number and resorption-dependent osteoblast activity. Moreover, elevated osteoclasts and intracortical/calvarial porosity is exacerbated by overexpressing Sost and reversed by blocking resorption. Furthermore, increased cancellous bone is abolished by Wnt inhibition but further increased by blocking resorption. Thus, resorption induced by PTH receptor signaling in osteocytes is critical for full anabolism in cortical bone, but tempers bone gain in cancellous bone. Dissecting underlying mechanisms of PTH receptor signaling would allow targeting actions in different bone compartments, enhancing the therapeutic potential of the pathway.

Rhee Y; Lee EY; Lezcano V; Ronda AC; Condon KW; Allen MR; Plotkin LI; Bellido T

2013-08-01

310

Early predictors of hematoma resorption rate in medically treated patients with spontaneous supratentorial hemorrhage.  

UK PubMed Central (United Kingdom)

Spontaneous intracranial hemorrhages are associated with a relatively high mortality rate, and there is no effective treatment so far. Hematoma resorption speed after intracranial hemorrhage (ICH) is believed to correlate with clinical outcome. However, little is known about hematoma resorption rates following spontaneous ICH. The aim of this study is to identify factors that can influence the rate of hematoma resorption in patients with spontaneous supratentorial ICH. We studied 80 patients admitted at the First Affiliated Hospital of Xi'an JiaoTong University from November 2008 to April 2012. The rate of hematoma resorption was calculated for each patient by measuring the variation in the volume of the hematoma (mL) from two computerized tomography brain scans divided by the time factor (days) separating the respective scans. Non-parametric and standard multiple linear regression methods were used for statistical analysis. The size of the hematoma was identified as a predictor of the rate of hematoma resorption. For supratentorial hematomas with a maximum volume of 45 mL, the larger the volume, the greater the rate of resorption. Non-hypertensive patients had a more favorable rate of hematoma resorption than those who were hypertensive. A low serum high-density lipoprotein (HDL) level (<0.83 mmol/L) was associated with a slower hematoma resorption rate. Therefore, a spontaneous ICH hematoma of less than 45 mL, a history of chronic hypertension, and a lower level of HDL were found to be the predictors of the hematoma resorption rate in the first 7-day period following ICH onset.

Luo GG; Ramchurn A; Chen YF; Li YB; Yuan BB; Huo K; Yuan XY; Yang J

2013-04-01

311

Relationship between dental anomalies and orthodontic root resorption of upper incisors.  

UK PubMed Central (United Kingdom)

The aim of this study was to examine the potential relationship between the occurrence of orthodontic root resorption and presence of dental anomalies such as tooth agenesis and pipette-shaped roots. Dental anomalies and root resorption were assessed on dental panoramic tomographs (DPT) of 88 subjects, 27 males and 61 females, mean age 28.4 (SD = 11.3 years), selected from orthodontic patients on the basis of the following exclusion criteria: previous fixed appliance treatment, bad quality of the DPTs and no visibility of the periodontal ligament of every tooth, and younger than 15 years of age at the onset of treatment with fixed edgewise appliance lasting at least 18 months. A pipette-shaped root was identified as defined by a drawing. Tooth agenesis was assessed on DPTs and from subjects' dental history. Root resorption was calculated as the difference between the root length before and after treatment, with and without a correction factor (crown length post-treatment/crown length pre-treatment). If one of the four upper incisors showed root resorption of ?2.3 mm with both formulas, the patient was scored as having root resorption. Chi-square tests indicated that there was no relationship between orthodontic root resorption and agenesis (P = 0.885) nor between orthodontic root resorption and pipette-shaped roots (P = 0.800). There was no relationship between having one of the anomalies and root resorption either (P = 0.750). In the present study, it was not possible to confirm on DPTs a relationship between orthodontic root resorption and dental anomalies, such as agenesis and pipette-shaped roots.

Van Parys K; Aartman IH; Kuitert R; Zentner A

2012-10-01

312

Relationship between dental anomalies and orthodontic root resorption of upper incisors.  

Science.gov (United States)

The aim of this study was to examine the potential relationship between the occurrence of orthodontic root resorption and presence of dental anomalies such as tooth agenesis and pipette-shaped roots. Dental anomalies and root resorption were assessed on dental panoramic tomographs (DPT) of 88 subjects, 27 males and 61 females, mean age 28.4 (SD = 11.3 years), selected from orthodontic patients on the basis of the following exclusion criteria: previous fixed appliance treatment, bad quality of the DPTs and no visibility of the periodontal ligament of every tooth, and younger than 15 years of age at the onset of treatment with fixed edgewise appliance lasting at least 18 months. A pipette-shaped root was identified as defined by a drawing. Tooth agenesis was assessed on DPTs and from subjects' dental history. Root resorption was calculated as the difference between the root length before and after treatment, with and without a correction factor (crown length post-treatment/crown length pre-treatment). If one of the four upper incisors showed root resorption of ?2.3 mm with both formulas, the patient was scored as having root resorption. Chi-square tests indicated that there was no relationship between orthodontic root resorption and agenesis (P = 0.885) nor between orthodontic root resorption and pipette-shaped roots (P = 0.800). There was no relationship between having one of the anomalies and root resorption either (P = 0.750). In the present study, it was not possible to confirm on DPTs a relationship between orthodontic root resorption and dental anomalies, such as agenesis and pipette-shaped roots. PMID:21745825

Van Parys, Katrien; Aartman, Irene H A; Kuitert, Reinder; Zentner, Andrej

2011-07-10

313

Three-dimensional assessment of impacted canines and root resorption using cone beam computed tomography.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The objective of this study was to localize impacted canines in 3 dimensions and determine the most common location of impaction using cone beam computed tomography (CBCT). We also assessed root resorption of adjacent teeth. The cusp tip of each impacted canine was located and digitized using Dolphin 3D imaging, after viewing sagittal, coronal, and axial views. The position on the occlusal plane where the normally erupted canine cusp tip should be located was used as a control reference point. The degree of impaction was defined by the difference between the impacted canine cusp tip and reference cusp tip positions. MATERIALS AND METHODS: CBCT scans of 29 consecutive individuals with impacted canines undergoing orthodontic treatment at the UCSF Orthodontic Clinic were included in this study. RESULTS: The average degree of mesial impactions was 10.1 mm, of distal impactions was 4.2 mm, of facial impactions was 4.16 mm, of palatal impactions was 1.8 mm, and of gingival impactions was 10 mm; 40.4% had no root resorption, 35.7% showed slight root resorption, 14.2% showed moderate resorption, and 4% showed severe root resorption of the adjacent lateral incisor. CONCLUSION: We reliably assessed the position of impacted canines in 3 dimensions using CBCT, thereby improving accuracy of location and facilitating precise surgical and orthodontic management. In our study 40.4% had no root resorption, 35.7% showed slight root resorption, 14.2% showed moderate resorption, and 4% showed severe root resorption of the adjacent lateral incisor. The most frequent location of impacted canines was palatal, mesial, and gingival.

Oberoi S; Knueppel S

2012-02-01

314

Primary alveolar hypoventilation and XXXXY chromosopathy.  

UK PubMed Central (United Kingdom)

The association of primary alveolar hypoventilation (PAH) and chromosomic diseases has not been described previously. A 19 year-old man with Fraccaro's syndrome (XXXXY karyotype) was admitted to evaluate chronic hypercapnic respiratory failure, pulmonary arterial hypertension and cor pulmonale. PAH was diagnosed. As effective treatment, such as non-invasive positive pressure ventilation (NIPPV), is available for this disorder we should intensify the search for PAH in patients with chromosome disease.

Samolski D; Antón A; Mayos M; Subirana M; Güell R

2006-09-01

315

Primary alveolar hypoventilation and XXXXY chromosopathy.  

Science.gov (United States)

The association of primary alveolar hypoventilation (PAH) and chromosomic diseases has not been described previously. A 19 year-old man with Fraccaro's syndrome (XXXXY karyotype) was admitted to evaluate chronic hypercapnic respiratory failure, pulmonary arterial hypertension and cor pulmonale. PAH was diagnosed. As effective treatment, such as non-invasive positive pressure ventilation (NIPPV), is available for this disorder we should intensify the search for PAH in patients with chromosome disease. PMID:17220108

Samolski, D; Antón, A; Mayos, M; Subirana, M; Güell, R

2006-09-01

316

Tantalum oxide and alveolar macrophage function.  

UK PubMed Central (United Kingdom)

The alveolar macrophage (AM) has been cited as a potential source for clearing tantalum from the lungs following bronchography. We studied the short term effects of tantalum oxide on rabbit AM viability and metabolism in vitro. AM phagocytosed tantalum oxide particles without cytotoxicity and with a significant rise in glucoxe oxidation. These results suggest that the AM represents an important vehicle for clearance of tantalum particles from airways in vivo.

Matthay RA; Putman CE; Gee JB; Smith GJ; McCloud T; Greenspan RH

1977-05-01

317

Phagocytic properties of lung alveolar wall cells  

Directory of Open Access Journals (Sweden)

Full Text Available For the purpose to define the mechanism of heavy metal intoxication by inhalation, morphologic observations were made on rat lungs after nasal instillation of iron colloid particles of positive and negative electric charges. Histochemical observation was also made on the liver and spleen of these animals. The instilled iron colloid particles reach the alveolar cavity easily, as can be seen in the tissue sections stained by Prussian blue reaction. Alveolar macrophages do take up them avidly both of positive and negative charges, though much less the positive particles than negative ones. In contrast, the alveolar epithelial cells take up solely positive particles by phagocytosis but not negative ones. Electron microscope observation revealed that the positive particles are ingested by Type I epithelial cells by pinocytosis and by Type II cells by phagocytosis as well. Then the iron colloid particles are transferred into the basement membrane by exocytosis. Travelling through the basement membrane they are again taken up by capillary endothelial cells by phagocytosis. Some particles were found in the intercellular clefts of capillary endothelial cells but not any iron colloid particles in the intercellular spaces of epithelial cells and in the capillary lumen. However, the liver and spleen tissues of the animals given iron colloid showed a strong positive iron reaction. On the basis of these observations, the mechanism of acute intoxication by inhaling heavy metal dusts like lead fume is discussed from the view point of selective uptake of alveolar epithelial and capillary endothelial cells for the particles of the positive electric cha'rge.

Tanaka,Akisuke

1974-01-01

318

The thickness of facial alveolar bone overlying healthy maxillary anterior teeth.  

UK PubMed Central (United Kingdom)

BACKGROUND: A facial bone (<2 mm) overlying maxillary anterior teeth may be prone to resorptive processes after extraction and immediate implant placement. A thin bone contributes to risk of bone fenestration, dehiscence, and soft-tissue recession. This study measures the distance between the cemento-enamel junction (CEJ) and alveolar bone crest and the thickness of facial alveolar bone at points 1 to 5 mm from the bone crest for the six maxillary anterior teeth. METHODS: Sixty-six tomographic scans (31 males and 35 females; aged 17 to 69 years; mean age: 39.9 years) of intact anterior maxilla were randomly selected and evaluated by two calibrated and independent examiners (MG and TP). RESULTS: A high variation of CEJ-bone crest (0.8 to 7.2 mm) was detected. A significantly larger CEJ-bone crest was measured in smokers (P <0.05) and patients who were ?50 years old (P <0.05). The average bone thickness at 3 mm from the CEJ for the maxillary right central incisor was 1.41 mm and for the maxillary left central incisor was 1.45 mm. For the maxillary right and left lateral incisors, the crestal bone thickness averaged 1.73 and 1.59 mm, respectively. For the maxillary right and left canines, the crestal bone thickness averaged 1.47 and 1.60 mm, respectively. CONCLUSIONS: The present study supports the finding of a predominantly thin facial bone overlying the six maxillary anterior teeth. Therefore, it is essential to make informed treatment decisions based on thorough site evaluation before immediate implant placement.

Ghassemian M; Nowzari H; Lajolo C; Verdugo F; Pirronti T; D'Addona A

2012-02-01

319

In situ methods for assessing alveolar mechanics.  

UK PubMed Central (United Kingdom)

Lung mechanics are an important determinant of physiological and pathophysiological lung function. Recent light microscopy studies of the intact lung have furthered the understanding of lung mechanics but used methodologies that may have introduced artifacts. To address this concern, we employed a short working distance water immersion objective to capture confocal images of a fluorescently labeled alveolar field on the costal surface of the isolated, perfused rat lung. Surface tension held a saline drop between the objective tip and the lung surface, such that the lung surface was unconstrained. For comparison, we also imaged with O-ring and coverslip; with O-ring, coverslip, and vacuum pressure; and without perfusion. Under each condition, we ventilated the lung and imaged the same region at the endpoints of ventilation. We found use of a coverslip caused a minimal enlargement of the alveolar field; additional use of vacuum pressure caused no further dimensional change; and absence of perfusion did not affect alveolar field dimension. Inflation-induced expansion was unaltered by methodology. In response to inflation, percent expansion was the same as recorded by all four alternative methods.

Wu Y; Perlman CE

2012-02-01

320

Osteoplasty of the alveolar cleft defect.  

Science.gov (United States)

Cleft of lip, alveolar process and palate is the most common congenital defect affecting the face. It occurs at the time of early embryogenesis as a result of disturbed differentiation of the primordial cell layer and is associated with genetic and environmental factors. The most severe type of the defect is complete cleft of the lip, alveolar process and palate, unilateral or bilateral, which is accompanied by impaired breathing, sucking, swallowing, chewing, hearing and speaking. The treatment consists in the surgical reconnection (reconstruction) of the cleft anatomical structures and their formation to gain proper appearance, occlusal conditions and speech. The part of the surgical treatment is reconstruction of alveolar bone by means of autogenic spongy bone grafting (osteoplasty). The surgery performed at the stage of mixed dentition following an orthodontic treatment is a recognized standard management modality. Its effects provide stabilization of the dental arches fixed in the orthodontic treatment, possibility of growth of permanent teeth adjoining the cleft as well as separation of the nasal and oral cavities. The grafted bone becomes a platform for the collapsed base of the ala nasi and facilitates restoration of teeth loss. In the graft healing process the volume of the regenerated bone tissue is lower than the graft volume. Methods to augment the healed bone volume are being searched for, as this factor decides substantially on successful outcome of the surgery. PMID:23214291

Rychlik, Dariusz; Wójcicki, Piotr; Ko?lik, Maciej

 
 
 
 
321

Osteoplasty of the alveolar cleft defect.  

UK PubMed Central (United Kingdom)

Cleft of lip, alveolar process and palate is the most common congenital defect affecting the face. It occurs at the time of early embryogenesis as a result of disturbed differentiation of the primordial cell layer and is associated with genetic and environmental factors. The most severe type of the defect is complete cleft of the lip, alveolar process and palate, unilateral or bilateral, which is accompanied by impaired breathing, sucking, swallowing, chewing, hearing and speaking. The treatment consists in the surgical reconnection (reconstruction) of the cleft anatomical structures and their formation to gain proper appearance, occlusal conditions and speech. The part of the surgical treatment is reconstruction of alveolar bone by means of autogenic spongy bone grafting (osteoplasty). The surgery performed at the stage of mixed dentition following an orthodontic treatment is a recognized standard management modality. Its effects provide stabilization of the dental arches fixed in the orthodontic treatment, possibility of growth of permanent teeth adjoining the cleft as well as separation of the nasal and oral cavities. The grafted bone becomes a platform for the collapsed base of the ala nasi and facilitates restoration of teeth loss. In the graft healing process the volume of the regenerated bone tissue is lower than the graft volume. Methods to augment the healed bone volume are being searched for, as this factor decides substantially on successful outcome of the surgery.

Rychlik D; Wójcicki P; Ko?lik M

2012-03-01

322

Apical root resorption 6 months after initiation of fixed orthodontic appliance therapy.  

UK PubMed Central (United Kingdom)

INTRODUCTION: Individual predisposition might be a major reason for the observed variation in apical orthodontic root resorption. If so, resorption might be expressed during the initial stages of orthodontic therapy in patients at risk. METHODS: To explore this hypothesis, we evaluated standardized, digitized periapical radiographs made before treatment (T1) and at a mean period of 6.4 months (SD 0.9) after placement of maxillary incisor brackets (T2) in 290 patients (age range, 10.1 to 57.1 years at T1). Anamnestic and treatment parameters were recorded according to a protocol, and maxillary incisor irregularity was measured on T1 study models. RESULTS: The mean average root resorption for 4 incisors was 0.53 mm (SD 0.47), whereas the sample mean of the most severely resorbed tooth per patient was 1.18 mm (SD 0.86). A total of 4.1% of the patients had an average resorption of 1.5 mm or more, and 15.5% had at least 1 tooth with 2.0 mm or more resorption. The maximum amount of resorption was 4.4 mm. Multivariate linear regression showed that deviated root form and increased T1-to-T2 time period were risk factors for apical root resorption of the central incisors; normal root form and wide roots were preventive factors, with an explained variance of 14%. Similarly, long roots, narrow roots, and increased T1-to-T2 time period were risk factors for resorption of the lateral incisors, whereas normal root form was a preventive factor, with an explained variance of 24%. Parameters associated with use of rectangular wire, presence of incisor irregularity, and history of trauma were not identified as risk factors. Use of elastics was not included in the regression analyses. CONCLUSIONS: Root resorption can begin in the early leveling stages of orthodontic treatment. About 4.1% of patients studied had an average resorption of 1.5 mm or more of the 4 maxillary incisors, and about 15.5% had 1 or more maxillary incisors with resorption of 2.0 mm or more from 3 to 9 months after initiation of fixed appliance therapy. Although teeth with long, narrow, and deviated roots are at increased risk of resorption during this early stage, the explained variance of these risk factors is less than 25%.

Smale I; Artun J; Behbehani F; Doppel D; van't Hof M; Kuijpers-Jagtman AM

2005-07-01

323

[Simulation of bone resorption in denture patients using finite element analysis. 1. Application of optimization method  

UK PubMed Central (United Kingdom)

The purpose of this study was to simulate the process of bone resorption under removable denture bases. Two dimensional finite element models were prepared for the frontal section of a maxillary complete denture with its supporting mucosa and bone in the first molar region. Simulations were performed with the optimization program which could proportionally move the nodal points according to the stress level difference between the actual and the reference stress level. By exerting loads on occlusal table of the model, the bone resorption progressed in the similar manner to reported clinical observations. The location and magnitude of the resorption were highly related to the location and direction of the loads.

Maeda Y; Tsutsumi S; Okada M; Idoji S; Nokubi T; Okuno Y

1989-04-01

324

Inferior alveolar nerve injuries associated with mandibular fractures.  

Science.gov (United States)

The study evaluates the incidence of inferior alveolar nerve injuries in mandibular fractures, the duration of their recovery, and the factors associated with them. Fifty-two patients with mandibular fractures involving the ramus, angle, and body regions were included in this study; the inferior alveolar nerve was examined for neurological deficit posttraumatically using sharp/blunt differentiation method, and during the follow-up period the progression of neural recovery was assessed. The incidence of neural injury of the inferior alveolar nerve was 42.3%, comminuted and displaced linear fractures were associated with higher incidence of inferior alveolar nerve injury and prolonged recovery time, and recovery of inferior alveolar nerve function occurred in 91%.Fractures of the mandible involving the ramus, angle, and body regions, and comminuted and displaced linear fractures are factors that increase the incidence of inferior alveolar nerve injuries. Missile injuries can be considered as another risk factor. PMID:23147318

Bede, Salwan Yousif Hanna; Ismael, Waleed Khaleel; Al-Assaf, Dhuha A; Omer, Saad Salem

2012-11-01

325

Biocompatibility and resorption of a radiopaque premixed calcium phosphate cement.  

UK PubMed Central (United Kingdom)

Calcium phosphate cements (CPC) are used as bone void filler in various orthopedic indications; however, there are some major drawbacks regarding mixing, transfer, and injection of traditional CPC. By using glycerol as mixing liquid, a premixed calcium phosphate cement (pCPC), some of these difficulties can be overcome. In the treatment of vertebral fractures the handling characteristics need to be excellent including a high radio-opacity for optimal control during injection. The aim of this study is to evaluate a radiopaque pCPC regarding its resorption behavior and biocompatibility in vivo. pCPC and a water-based CPC were injected into a Ø 4-mm drilled femur defect in rabbits. The rabbits were sacrificed after 2 and 12 weeks. Cross sections of the defects were evaluated using histology, electron microscopy, and immunohistochemical analysis. Signs of inflammation were evaluated both locally and systemically. The results showed a higher bone formation in the pCPC compared to the water-based CPC after 2 weeks by expression of RUNX-2. After 12 weeks most of the cement had been resorbed in both groups. Both materials were considered to have a high biocompatibility since no marked immunological response was induced and extensive bone ingrowth was observed. The conclusion from the study was that pCPC with ZrO(2) radiopacifier is a promising alternative regarding bone replacement material and may be suggested for treatment of, for example, vertebral fractures based on its high biocompatibility, fast bone ingrowth, and good handling properties.

Aberg J; Henriksson HB; Engqvist H; Palmquist A; Brantsing C; Lindahl A; Thomsen P; Brisby H

2012-05-01

326

Effect of allergen sensitization on external root resorption.  

Science.gov (United States)

In orthodontic tooth movement (OTM), we should be concerned about external root resorption (ERR) as an undesirable iatrogenic problem, but its mechanisms are not fully understood. Since our previous epidemiologic studies found that patients with allergic diseases showed higher rates of ERR during orthodontic treatment, we explored the possible effect of allergic sensitization on ERR. In ovalbumin (OVA)-sensitized Brown-Norway rats, the amounts of ERR and OTM were greater than those in animals subjected to orthodontic force alone. The expression levels of RANKL and pro-inflammatory cytokines were increased in the periodontal tissues of sensitized rats with OTM, compared with control rats. Furthermore, leukotriene B4 (LTB4), a potent lipid mediator of allergic inflammation, and enzymes of the 5-lipoxygenase pathway, the biosynthetic pathway of leukotrienes, were also up-regulated. We found that low doses of aspirin suppressed ERR in allergen-sensitized rats, as well as the expressions of RANKL, pro-inflammatory cytokines, and LTB4. The present findings indicate that allergen sensitization has adverse effects on ERR under OTM, and that aspirin is a potential therapeutic agent for combating ERR. PMID:23648742

Murata, N; Ioi, H; Ouchi, M; Takao, T; Oida, H; Aijima, R; Yamaza, T; Kido, M A

2013-05-06

327

Vitamin B1 resorption. X.Changes in thiamine resorption in the small intestine of chickens and rats treated with somatotropic hormone  

International Nuclear Information System (INIS)

A trial was carried out with broiler chickens aged one month and Wistar male albino rats of mean liveweight of 207 g. The chickens were intramusculary injected with somatotropic hormone (STH), Sotropin H (DDR) 2 units/1O0 g liveweight for 3 successive days and the rats - 4 days. Intestine alkaline phosphatase activity was determined for a separate group of chickens post hormone injection. The resorption of 35S-thiamine, introduced in bilaterally ligated duodenum, 30 ?Ci/kg liveweight, was studied in chickens; in rats -the resorption of thiamine chloride (non radioactive), 20O ?g dissolved in 3 ml volume, introduced in the lupen of the entire small intestine (duodenum, jejunum, ileum) bilaterally ligated. It was found that STH enhanced thiamine both in chickens and rats (p 1 resorption in the small intestine (2, 3). Thiamine resorption depends on the activity of metabolic processes in small intestine epithelium. This is confirmed by data on the effect of sodium fluoride (NaF) and monoiodoacetic acid (MIAA). Thiamine resorption is depressed when 10-2M or 1O-3M MIAA are jointly introduced in the lumen of the intestine. When the action of NaF and MIAA takes place against the background of STH action, then thiamine resorption goes up and equal that of the control group. NaF inhibits small intestine respiratory activity. These results are interpreted in the sense that the active thiamine transport is influenced by STH which restores the enzyme and respiratory activity of intestine epithelial cells. (author).

1977-01-01

328

Reduction of mandibular residual ridge after vestibuloplasty. A two-year follow-up study comparing the Edlan flap, mucosal and skin graft operations  

DEFF Research Database (Denmark)

Mandibular residual ridge reduction (RRR) after Edlan flap vestibuloplasty, buccal mucosal graft, and split skin graft vestibuloplasty was measured on lateral cephalometric radiographs obtained 1, 3, 6, 12 and 24 months postsurgery in 50 patients. The ridge reduction was most severe during the immediate postoperative period. The different operation methods did not give rise to significant variations in the reduction pattern, neither did the sex of the patient appear to be an important factor. The temporary increase of mandibular resorption after vestibuloplasty surgery is of a magnitude comparable to the average RRR during 1 year in full denture wearers with a long denture experience.

Hillerup, SØren; Eriksen, Erik

1989-01-01

329

Alveolar haemorrhage in a case of high altitude pulmonary oedema.  

UK PubMed Central (United Kingdom)

A case of high altitude pulmonary oedema (HAPE) in a climber who made a rapid ascent on Mt McKinley (Denali), Alaska is described. The bronchoalveolar lavage (BAL) fluid contained increased numbers of red blood cells and an abundance of haemosiderin laden macrophages consistent with alveolar haemorrhage. The timing of this finding indicates that alveolar haemorrhage began early during the ascent, well before the onset of symptoms. Although evidence of alveolar haemorrhage has been reported at necropsy in individuals dying of HAPE, previous reports have not shown the same abundance of haemosiderin laden macrophages in the BAL fluid. These findings suggest that alveolar haemorrhage is an early event in HAPE.

Grissom CK; Albertine KH; Elstad MR

2000-02-01

330

Pulpal status of human primary molars with coexisting caries and physiological root resorption.  

UK PubMed Central (United Kingdom)

CONCLUSION: Findings suggest that even if primary molars are undergoing exfoliation, they show comparable caries-induced changes to teeth without physiological root resorption, thus retaining potential for healing and repair.

Rajan S; Day PF; Christmas C; Munyombwe T; Duggal M; Rodd HD

2013-10-01

331

Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia.  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Recent studies demonstrate that bisphosphonates suppress bone resorption by leading to apoptosis of the osteoclast and inhibiting the differentiation to mature osteoclasts. The influence of bisphosphonates on bone formation is unknown, although it has been hypothesized that bisphosphonates inhibit o...

Iwata, Ken; Li, Jiliang; Follet, Hélène; Phipps, Roger; Burr, David

332

Intermittent therapy with 1,25 vitamin D and calcitonin prevents cyclosporin-induced alveolar bone loss in rats.  

UK PubMed Central (United Kingdom)

Bone loss associated with cyclosporin A (CsA) therapy can result in serious morbidity to patients. Intermittent administration of 1,25 Vitamin D and calcitonin reduces osteopenia in a murine model of postmenopausal osteoporosis. The purpose of this study was to evaluate the effects of this therapeutic approach on CsA-induced alveolar bone loss in rats. Forty male Wistar rats were allocated to four experimental groups according to the treatment received during 8 weeks: (1) CsA (10 mg/kg/day, s.c.); (2) 1,25 Vitamin D (2 microg/kg, p.o.; in weeks 1, 3, 5, and 7) plus calcitonin (2 microg/kg, i.p.; in weeks 2, 4, 6, and 8); (3) CsA concurrently with intermittent 1,25 Vitamin D and calcitonin administration; and (4) the control treatment group (vehicle). At the end of the 8-week treatment period, serum concentrations of bone-specific alkaline phosphatase, tartrate-resistant acid phosphatase (TRAP-5b), osteocalcin, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor alpha (TNF-alpha) were measured and an analysis of bone volume, bone surface, number of osteoblasts, and osteoclasts was performed. CsA administration resulted in significant alveolar bone resorption, as assessed by a lower bone volume and an increased number of osteoclasts, and increased serum bone-specific alkaline phosphatase, TRAP-5b, IL-1 beta, IL-6, and TNF-alpha concentrations. The intermittent administration of calcitriol and calcitonin prevented the CsA-induced osteopenic changes and the increased serum concentrations of TRAP-5b and inflammatory cytokines. Intermittent calcitriol/calcitonin therapy prevents CsA-induced alveolar bone loss in rats and normalizes the production of associated inflammatory mediators.

Spolidorio LC; Herrera BS; Coimbra LS; Spolidorio DM; Muscará MN; Rossa C Jr

2010-09-01

333

Cowley Ridge expansion planned  

Energy Technology Data Exchange (ETDEWEB)

Five new wind turbines with a total capacity of 1,875 MW will be added to its Cowley Ridge wind plant in southern Alberta by the Calgary-based Canadian Hydro Developers. The anticipated 5,500 MWh per year output of the new turbines will be sold into the province's power pool. The new addition will represent a 10 per cent increase to the Cowley Ridge plant's capacity and will be Canada's first merchant wind installation. In the longer term, Canadian Hydro Developers expect to find buyers who will purchase the power on a short-term contract basis. The new turbines are Kenetech KVS33s, manufactured prior to to Kenetech's 1996 bankruptcy. Canadian Hydro Developers has other projects planned, but these are temporarily shelved due to the scarcity of capital, caused by consumer reluctance to accept 'green power' as a viable alternative to conventional power, and governments' reticence to encourage the transition to renewable energy sources.

Anon.

2000-06-01

334

Accuracy of an electronic apex locator: a clinical evaluation in primary molars with and without resorption.  

UK PubMed Central (United Kingdom)

OBJECTIVE: The aim of this study was to evaluate the accuracy of electronic apex locator (Root ZX) in primary teeth with and without apical root resorption in vivo. STUDY DESIGN: The electronic working length was determined in 28 primary teeth (A total of 46 primary molar root canals with 24 roots without resorption and 22 roots with resorption) from twenty-eight healthy children using Root ZX. The teeth were then extracted. The actual length of each root was measured placing a K-File until the tip was visible at the apical foramen or the apical resorption level and approved with digital microscopic evaluation under 20x magnification and then withdrawn 1 mm. The distances from the file tip to the base of the rubber stop were measured and compared with the measurement obtained from apex locator. The data were evaluated with t test using standard statistical software (SPSS 13.0). The critical value of statistical significance was 5%. RESULTS: For root canals without resorption, the accuracy of Root ZX was 79.16% and 95.82% within +/- 0.5 and +/- 1 mm, respectively. For root canals with resorption, the accuracy of Root ZX was 63.63% and 86.35% within +/- 0.5 and +/- 1 mm, respectively. No statistically significant differences were detect between the electronically determined lengths and the actual lengths regardless of whether or not resorption. CONCLUSION: Using a Root ZX Electronic Apex Locator in primary teeth with or without resorption is recommended for the determination of working length.

Odaba? ME; Bodur H; Tuluno?lu O; Alaçam A

2011-01-01

335

Mechanism of osteoclast mediated bone resorption--rationale for the design of new therapeutics.  

Science.gov (United States)

Bone resorption is an important cellular function in the development and physiology of the skeleton. Pathophysiology of several skeletal diseases includes either increased (for instance osteoporosis, metastatic bone disease and Paget's disease of bone) or decreased (various syndromes of osteopetrosis) bone resorption rate. Thus there is a genuine need to regulate, especially inhibit, bone resorption rate in several diseases. Bone resorption can be inhibited by several strategies. One can prevent osteoclast formation, inhibit their action or induce premature cell death. All these strategies have been used in pharmacology to inhibit bone resorption and there are also physiological regulators for each of these three different phases of in osteoclast life. Many present resorption inhibitors inhibit osteoclast formation via osteoblastic cells since they are producing a number of factors that are essential for osteoclast differentiation. Best characterized of these factors are macrophage colony stimulating factor (M-CSF) and receptor activator of NFêB ligand (RANKL). For instance sex steroids, parathyroid hormone and some interleukins are known to exert their positive or negative effects on osteoclast differentiation via the RANK/RANKL/osteoprotegrin pathway. It is not yet clear enough how specific intervention to osteoclast formation is since also other cell lineages derived from hematopoetic precursors use similar signalling pathways. An effective inhibition of bone resorption can also be achieved by inhibiting osteoclast activity to resorb bone. Examples of this category of physiological and pharmacological inhibitors are calcitonin and aminobisphosphonates, respectively. Finally one can reduce bone resorption by shortening osteoclast lifespan with substances that induce apoptosis in osteoclasts. A good example of these substances is a first generation bisphosphonate, clodronate. Several new potential molecular targets have been revealed during recent years since many individual molecules in osteoclast differentiation, function and apoptosis have been identified and their physiological functions revealed. Thus we are expecting several new bone inhibitors to be developed in following years both for experimental studies and finally also for clinical use. PMID:15876398

Väänänen, Kalervo

2005-04-15

336

Mechanism of osteoclast mediated bone resorption--rationale for the design of new therapeutics.  

UK PubMed Central (United Kingdom)

Bone resorption is an important cellular function in the development and physiology of the skeleton. Pathophysiology of several skeletal diseases includes either increased (for instance osteoporosis, metastatic bone disease and Paget's disease of bone) or decreased (various syndromes of osteopetrosis) bone resorption rate. Thus there is a genuine need to regulate, especially inhibit, bone resorption rate in several diseases. Bone resorption can be inhibited by several strategies. One can prevent osteoclast formation, inhibit their action or induce premature cell death. All these strategies have been used in pharmacology to inhibit bone resorption and there are also physiological regulators for each of these three different phases of in osteoclast life. Many present resorption inhibitors inhibit osteoclast formation via osteoblastic cells since they are producing a number of factors that are essential for osteoclast differentiation. Best characterized of these factors are macrophage colony stimulating factor (M-CSF) and receptor activator of NFêB ligand (RANKL). For instance sex steroids, parathyroid hormone and some interleukins are known to exert their positive or negative effects on osteoclast differentiation via the RANK/RANKL/osteoprotegrin pathway. It is not yet clear enough how specific intervention to osteoclast formation is since also other cell lineages derived from hematopoetic precursors use similar signalling pathways. An effective inhibition of bone resorption can also be achieved by inhibiting osteoclast activity to resorb bone. Examples of this category of physiological and pharmacological inhibitors are calcitonin and aminobisphosphonates, respectively. Finally one can reduce bone resorption by shortening osteoclast lifespan with substances that induce apoptosis in osteoclasts. A good example of these substances is a first generation bisphosphonate, clodronate. Several new potential molecular targets have been revealed during recent years since many individual molecules in osteoclast differentiation, function and apoptosis have been identified and their physiological functions revealed. Thus we are expecting several new bone inhibitors to be developed in following years both for experimental studies and finally also for clinical use.

Väänänen K

2005-05-01

337

The extramandibular inferior alveolar nerve in cases with severely atrophic lower jaws.  

UK PubMed Central (United Kingdom)

There are very few evidences on the extramandibular course (EMC) of the inferior alveolar nerve (IAN). We report here two such cases. The first one was encountered at dissection, in a human adult female cadaver where the right IAN terminal division was identified in the premolar region, above a severely atrophied mandibular body. The second case was a patient evaluated by cone-beam CT, who presented with an extremely atrophic mandible with bilateral extramandibular courses of the IANs. Such severe atrophy of the mandible may be considered as residual ridge class 7 along with the existing Atwood classes. EMCs of the IAN may not only occur in extreme mandibular atrophy, but also in dentate mandibles. In edentulous mandibles, an extramandibular IAN may complicate local surgical procedures or hamper denture wearing.

Rusu MC; S?ndulescu M; Ciuluvic? RC; Sendroiu VM; Didilescu AC

2012-04-01

338

External root resorption after orthodontic treatment: a study of contributing factors  

Energy Technology Data Exchange (ETDEWEB)

The purpose of this study was to examine the patient- and treatment-related etiologic factors of external root resorption. This study consisted of 163 patients who had completed orthodontic treatments and taken the pre- and post-treatment panoramic and lateral cephalometric radiographs. The length of tooth was measured from the tooth apex to the incisal edge or cusp tip on the panoramic radiograph. Overbite and overjet were measured from the pre- and post-treatment lateral cephalometric radiographs. The root resorption of each tooth and the factors of malocclusion were analyzed with an analysis of variance. A paired t test was performed to compare the mean amount of root resorption between male and female, between extraction and non-extraction cases, and between surgery and non-surgery groups. Correlation coefficients were measured to assess the relationship between the amount of root resorption and the age in which the orthodontic treatment started, the degree of changes in overbite and overjet, and the duration of treatment. Maxillary central incisor was the most resorbed tooth, followed by the maxillary lateral incisor, the mandibular central incisor, and the mandibular lateral incisor. The history of tooth extraction was significantly associated with the root resorption. The duration of orthodontic treatment was positively correlated with the amount of root resorption. These findings show that orthodontic treatment should be carefully performed in patients who need the treatment for a long period and with a pre-treatment extraction of teeth.

Jung, Yun Hoa; Cho, Bong Hae [School of Dentistry, Pusan National University, Pusan (Korea, Republic of)

2011-03-15

339

The genetic contribution to orthodontic root resorption: a retrospective twin study.  

UK PubMed Central (United Kingdom)

BACKGROUND: One of the difficulties in assessing the causes of root resorption is to separate the contribution made by genetic factors from those due to environmental factors, such as treatment. OBJECTIVE: The aim of this study was to investigate the genetic contribution to orthodontic root resorption. METHODS: The subjects of this investigation were 16 monozygotic (MZ) and 10 dizygotic (DZ) twins. All twins had zygosity diagnosed using microsatellite analysis. Each twin-pair had same type of malocclusion, were treated with the same type of appliance, and by the same clinician. The lengths of the maxillary incisors, mandibular incisors, and mandibular molars were assessed both qualitatively and quantitatively, on pre- and post-treatment panoramic films. The genetic contribution to external apical root resorption was assessed using concordance and heritability estimates. RESULTS: Concordance estimates from the qualitatively and quantitatively measured external apical root resorption were 44.9 per cent and 49.2 per cent respectively for the MZ twins, and 24.7 per cent and 28.3 per cent respectively for DZ twins. An overall heritability estimate of 0.34 was obtained. CONCLUSIONS: External apical root resorption was not dependent on the pretreatment root length. Qualitatively and quantitatively determined estimates of concordance indicate a genetic component to root resorption. A larger sample is needed before models of heritability can be used to determine the components contributing to the variance.

Ngan DC; Kharbanda OP; Byloff FK; Darendeliler MA

2004-05-01

340

Effects of berberine on differentiation and bone resorption of osteoclasts derived from rat bone marrow cells  

Directory of Open Access Journals (Sweden)

Full Text Available Objective: To observe the effects of berberine on osteoclastic differentiation and bone resorption action in vitro, and to investigate the cellular mechanism of its inhibitory effects on bone resorption.Methods: The multinucleated osteoclasts (MNCs) were derived by 1,25-dihydroxyvitamin D3 and dexamethasone from bone marrow cells in the coculture system with primary osteoblastic cells. The tartrate-resistant acid phosphatase (TRAP) staining and image analysis of bone resorption pit on dental slices were used to identify osteoclast. The activity of TRAP was measured by p-nitrophenyl sodium phosphate assay. The bone resorption pit area on the bone slices formed by osteoclasts was measured by computer image processing.Results: At the concentrations of 0.1, 1 and 10 ?mol/L, berberine dose-dependently suppressed the formation of TRAP-positive multinucleated cells, the TRAP activity and the osteoclastic bone resorption. The strongest inhibitory effect was exhibited at the concentration of 10 ?mol/L, with the inhibiting rate of 60.45%, 42.12% and 72.69% respectively.Conclusion: Berberine can decrease bone loss through inhibition of osteoclast formation, differentiation and bone resorption.

Peng WEI; Qiao-yan ZHANG

2009-01-01

 
 
 
 
341

Conditional deletion of epithelial IKK? impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis  

Digital Repository Infrastructure Vision for European Research (DRIVER)

Abstract Background Alveolar septation marks the beginning of the transition from the saccular to alveolar stage of lung development. Inflammation can disrupt this process and permanently impair alveolar formation resulting in alveolar hypoplasia as seen in bronchopulmonary dysplasi...

Londhe Vedang A; Maisonet Tiffany M; Lopez Benjamin; Jeng Jade-Ming; Xiao Jing; Li Changgong; Minoo Parviz

342

Minimally invasive approach with tissue engineering for severe alveolar bone atrophy case.  

UK PubMed Central (United Kingdom)

The gold standard of bone augmentation for dental implants in severe alveolar bone atrophy is autogenous bone graft, but it has disadvantages such as limited amounts of grafted bone, poor morphological and aesthetic outcomes, and donor-site morbidity and invasiveness, especially in cases with diseases. In this reported case, the authors applied a novel tissue engineering method as minimally invasive surgery for a 58-year-old patient who had severe bone atrophy. The method, tissue-engineered bone (TEB), composed of mesenchymal stem cells as stem cells, platelet-rich plasma as growth factor and guided bone regeneration membrane. After bone regeneration by TEB, three 13 mm long dental implants were inserted. Adequate bone regeneration was shown by radiological analysis and histological observation. The augmented bone height was 4.2mm after the operation and the radiopaque areas were increased. The clinical progress over 2 years showed a good course without bone resorption. These results indicated that TEB, as bone regeneration treatment with minimal invasiveness, could be useful as one of the novel options in dental implant treatment with severe bone atrophy.

Yamada Y; Hara K; Nakamura S; Ueda M; Ito K; Nagasaka T

2013-02-01

343

Influence of experimental liver injury on rat blood and alveolar bone under stress.  

UK PubMed Central (United Kingdom)

Experimental liver injury was induced to test rats with a daily injection of thioacetamide (ThAA). The doses used for intraperitoneal administrations were 50 mg/kg body weight. The loss of body weight in the 3-week test period was 15%. In the liver there was seen progressive changes which displayed cell necrosis and regeneration. The influence of ThAA on rat blood and serum was checked using standard biochemical assays consisting of the percentage of blood obtainable and the serum/blood ratio and analysis of serum alanine transferase, serum alkaline phosphatase, serum creatinine, and hydroxyproline in the acute, subacute, chronic, and necrotic stage of liver injury. With ThAA injections, the stimulated rate of glycosaminoglycan synthesis had its association to the serum calcium content. It decreased continuously as function of traumatization time. In the 3-week test period, histological findings show in the alveolar bone, around the teeth, when under occlusal stress and ThAA traumatization, the distinct decrease in osteoblastic activity and less osteoids indicating thus the decreased formation of new bone. Conspicuous osteoclastic resorption was also seen in the same area.

Lassila V; Virtanen P

1984-01-01

344

Sonography of trapezial ridge fractures.  

UK PubMed Central (United Kingdom)

Trapezial ridge fractures are very rare. These can be a diagnostic challenge and one needs to have a high index of suspicion. We report two cases of trapezial ridge fractures that were diagnosed sonographically and confirmed by cross-sectional imaging (CT or MRI). © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 2013.

Botchu R; Bianchi S

2013-08-01

345

Alveolar band in patients with cleft lip and cleft alveolar deformities.  

UK PubMed Central (United Kingdom)

A complete cleft of the lip is often interrupted by a Simonarzt band. Very rarely, a similar fibrous soft tissue band can be seen interrupting the complete cleft of the alveolus. This alveolar band has not been previously described in the literature.

Engelbrecht H; Bütow KW

2013-03-01

346

Alveolar epithelial fluid transport in acute lung injury: new insights.  

UK PubMed Central (United Kingdom)

Pulmonary oedema is a life-threatening condition that frequently leads to acute respiratory failure. From a physiological perspective, pulmonary oedema develops either because of an increase in lung vascular hydrostatic pressure or an increase in lung vascular permeability. Resolution of alveolar oedema depends on the active removal of salt and water from the distal air spaces of the lung across the distal lung epithelial barrier. Much has been learned about the molecular and cellular basis for oedema fluid reabsorption, including the role of apical ion transporters for sodium (epithelial sodium channel) and chloride (cystic fibrosis transmembrane conductance regulator), as well as the central importance of the sodium pump. The rate of fluid clearance can be upregulated by both catecholamine-dependent and -independent mechanisms. Injury to the alveolar epithelium can disrupt the integrity of the alveolar barrier or downregulate ion transport pathways, thus, reducing net alveolar fluid reabsorption and enhancing the extent of alveolar oedema. Endogenous catecholamines upregulate alveolar fluid clearance in several experimental models of acute lung injury, but this upregulation may be short term and insufficient to counterbalance alveolar flooding. There is new evidence, however, that pharmacological treatment with beta2-adrenergic agonists and/or epithelial growth factors may influence a more sustained stimulation of alveolar fluid reabsorption and in turn facilitate recovery from experimental pulmonary oedema. Similar results have been achieved experimentally by gene transfer to enhance the abundance of sodium transporters in the alveolar epithelium. Clinical studies show that impaired alveolar fluid transport mechanisms contribute to the development, severity and outcome of pulmonary oedema in humans. Very recent data suggest that mechanisms that augment transepithelial sodium transport and enhance the clearance of alveolar oedema may lead to more effective prevention or treatment for some types of pulmonary oedema.

Sartori C; Matthay MA

2002-11-01

347

Nostril base augmentation effect of alveolar bone graft.  

UK PubMed Central (United Kingdom)

BACKGROUND: The aims of alveolar bone grafting are closure of the fistula, stabilization of the maxillary arch, support for the roots of the teeth adjacent to the cleft on each side. We observed nostril base augmentation in patients with alveolar clefts after alveolar bone grafting. The purpose of this study was to evaluate the nostril base augmentation effect of secondary alveolar bone grafting in patients with unilateral alveolar cleft. METHODS: Records of 15 children with alveolar clefts who underwent secondary alveolar bone grafting with autogenous iliac cancellous bone between March of 2011 and May of 2012 were reviewed. Preoperative and postoperative worm's-eye view photographs and reconstructed three-dimensional computed tomography (CT) scans were used for photogrammetry. The depression of the nostril base and thickness of the philtrum on the cleft side were measured in comparison to the normal side. The depression of the cleft side pyriform aperture was measured in comparison to the normal side on reconstructed three-dimensional CT. RESULTS: Significant changes were seen in the nostril base (P=0.005), the philtrum length (P=0.013), and the angle (P=0.006). The CT measurements showed significant changes in the pyriform aperture (P<0.001) and the angle (P<0.001). CONCLUSIONS: An alveolar bone graft not only fills the gap in the alveolar process but also augments the nostril base after surgery. In this study, only an alveolar bone graft was performed to prevent bias from other procedures. Nostril base augmentation can be achieved by performing alveolar bone grafts in children, in whom invasive methods are not advised.

Lee W; Park HJ; Choi HG; Shin DH; Uhm KI

2013-09-01

348

A possible association between early apical resorption of primary teeth and ectodermal characteristics of the permanent dentition.  

Science.gov (United States)

The hypothesis of this study is that children with unexpected early apical resorption of the primary teeth are also predisposed to resorption in the permanent dentition. Accordingly, the aim was to perform a longitudinal study focussing on the permanent teeth in children with unexpected early apical resorption in the primary dentition. Panoramic radiographs of 12 children (7 boys and 5 girls) aged 6 years 4 months to 8 years 9 months with unexpected early apical resorption of primary teeth were identified from a dental archive of 588 patients. After written request, follow-up radiographs were obtained (2-15 year interval between early and follow-up radiographs). The radiographs were examined in order to verify the abnormal resorption pattern of the primary teeth and dental deviations in the permanent teeth, known to predispose for root resorption (i.e. invaginations, narrow crowns, abrupt root deflections, slender roots, short roots, taurodontia, agenesis, deviant pattern of eruption). Primary dentition: Two phenotypically different resorption groups were identified: group I, eight patients (resorption of the roots only), and group II, four patients (resorption of root and crown). Permanent dentition: In all 12 children, dental deviations in the permanent dentition were observed. Additionally, idiopathic external apical resorption of the permanent teeth was seen in three children, two of whom had received orthodontic treatment. PMID:18678755

Bille, M L B; Kvetny, M J; Kjaer, I

2008-08-01

349

A possible association between early apical resorption of primary teeth and ectodermal characteristics of the permanent dentition.  

UK PubMed Central (United Kingdom)

The hypothesis of this study is that children with unexpected early apical resorption of the primary teeth are also predisposed to resorption in the permanent dentition. Accordingly, the aim was to perform a longitudinal study focussing on the permanent teeth in children with unexpected early apical resorption in the primary dentition. Panoramic radiographs of 12 children (7 boys and 5 girls) aged 6 years 4 months to 8 years 9 months with unexpected early apical resorption of primary teeth were identified from a dental archive of 588 patients. After written request, follow-up radiographs were obtained (2-15 year interval between early and follow-up radiographs). The radiographs were examined in order to verify the abnormal resorption pattern of the primary teeth and dental deviations in the permanent teeth, known to predispose for root resorption (i.e. invaginations, narrow crowns, abrupt root deflections, slender roots, short roots, taurodontia, agenesis, deviant pattern of eruption). Primary dentition: Two phenotypically different resorption groups were identified: group I, eight patients (resorption of the roots only), and group II, four patients (resorption of root and crown). Permanent dentition: In all 12 children, dental deviations in the permanent dentition were observed. Additionally, idiopathic external apical resorption of the permanent teeth was seen in three children, two of whom had received orthodontic treatment.

Bille ML; Kvetny MJ; Kjaer I

2008-08-01

350

Osteointegration and Resorption of Intra- and Extravertebral Calcium Phosphate Cement.  

UK PubMed Central (United Kingdom)

STUDY DESIGN:: eleven patients with painful osteoporotic vertebral fractures that underwent kyphoplasty using calcium phosphate (CaP) cement were followed-up for 1 week, 1, 2, and 3 years in a monocentric, non-randomized, non-controlled restrospective trial. OBJECTIVE:: This study investigates long-term radiomorphological features of intraosseous calcium phosphate cement implants and of extraosseous CaP cement leakages for up to 3 years after implantation via kyphoplasty. SUMMARY OF BACKGROUND DATA:: Kyphoplasty is frequently employed for the treatment of painful osteoporotic fractures. Of the materials available, CaP is frequently used as a filling material. Resorption of this material is frequently observed although clinical outcome is comparable to other cements. METHODS:: Kyphoplasty utilizing CaP cement was performed in 11 patients with painful osteoporotic vertebral fractures. All patients received a pharmacological antiosteoporosis treatment consisting of calcium, vitamin D and a standard dose of oral bisphosphonates. Radiomorphological measurements, pain and mobility were assessed. RESULTS:: Intra- and extraosseous CaP cement volumes decreased significantly over 3 years. However, vertebral stability as determined by a constant vertebral body height and the sagittal index was not impaired. Pain improved significantly two years after implantation and mobility scores after 1 year after kyphoplasty at least until the third year. CONCLUSION:: Intravertebral CaP cement implants are resorbed slowly over time without jeopardizing stability and clinical outcomes most likely due to a slowly progressing osseous replacement. Extraosseous CaP cement material due to leakages during the kyphoplasty procedure is almost completely resorbed as early as 2 years after the leakage occurred. Therefore, CaP cement is an important alternative to PMMA-based cement materials utilized for kyphoplasty of osteoporotic vertebral fractures.

Klein R; Tetzlaff R; Weiss C; Schäfer MK; Tanner M; Wiedenhöfer B; Grafe I; Meeder PJ; Noeldge G; Nawroth PP; Kasperk C

2013-09-01

351

Ridge preservation at implants installed immediately after molar extraction. An experimental study in the dog.  

UK PubMed Central (United Kingdom)

AIM: To evaluate the influence of deproteinized bovine bone mineral (DBBM), in conjunction with a collagen membrane, on bone resorption at implants installed in a lingual position immediately into extraction sockets with horizontal residual buccal defects >2.0 mm. MATERIAL & METHODS: The pulp tissue of the mesial roots of (1) M(1) was removed in six Labrador dogs, and the root canals were filled with gutta-percha and cement. Flaps were elevated. The molars were hemi-sectioned and the distal roots removed. Implants were installed in a lingual position and with the shoulder flush with the buccal bony crest. After installation, defects of about 2.5 and 2.7 mm in width resulted at the buccal aspects of the test and control sites, respectively. Only in the left site (test), deproteinized bovine bone mineral (DBBM) particles were placed into the defect concomitantly with the placement of a collagen membrane. On the control sites, no biomaterials were applied. A non-submerged healing was allowed. RESULTS: After 3 months of healing, one control implant was not integrated and was excluded from the analysis, together with the contralateral test implant. All remaining implants were integrated into mature bone. The buccal alveolar bony crest was resorbed more at the test compared with the control sites, 2.2 ± 0.9 mm and 1.5 ± 1.3 mm, respectively. The vertical resorption of the lingual plate was 1.6 ± 1.5 mm and 1.5 ± 1.1 mm at the test and control sites, respectively. Only small residual DBBM particles were found at the test sites (1.4%). CONCLUSION: The use of DBBM particles to fill buccal defects of ?2.5 mm at implants installed immediately into alveolar extraction sockets did not preserve the buccal bony wall.

Favero G; Lang NP; De Santis E; Gonzalez BG; Schweikert MT; Botticelli D

2013-03-01

352

Diffuse alveolar haemorrhage associated with aerosol propellant use.  

UK PubMed Central (United Kingdom)

Diffuse alveolar haemorrhage (DAH) is a clinical syndrome resulting from injury to the alveolar microcirculation, most commonly associated with not only autoimmune disorders or connective tissue disease, but also a variety of infections, neoplasms and toxins. We report here a case of an otherwise healthy young man with DAH attributable to an inhalation injury resulting from use of aerosol spray paint.

Kelchen P; Jamous F; Huntington MK

2013-01-01

353

Influence of balanced occlusion in complete dentures on the decrease in reduction of an edentulous ridge  

Directory of Open Access Journals (Sweden)

Full Text Available Background/Aim. Balanced occlusal arrangement of artificial teeth and balanced occlusion is a specific type of occlusion that preserves the stability of complete dentures. Balanced occlusion comprises realization of tooth contacts at the working side as well as at the balancing side, at the same time. The aim of this study was to assess the influence of balanced occlusal arrangement of artificial teeth on the decrease in reduction of edentulous alveolar ridge. Methods. A longitudinal study on 91 fully edentulous patients was conducted using their panoramic radiographs and parameters of vertical dimension of edentulous ridges. All the patients were clinically examined by the same and a qualified dental practitioner. Numerical values of parameters of vertical dimensions of edentulous ridges and lines were statistically processed and compared using the Student’s t-test. Results. Vertical dimensions and heights of edentulous ridges were different after comparison of parameters in complete denture wearers with balanced occlusion and complete denture wearers without bilaterally balanced occlusion, as well as between male and female edentulous patients. Statistically significant differences of heights were established in complete denture wearers’ with a set of artificial teeth without balanced occlusion, at the baseline and 12 months after wearing of complete dentures. Conclusion. Balanced occlusion is a favored occlusal design in setting of artificial teeth in conventional complete dentures, which preserves edentulous ridge and influence the stability of dentures.

Pošti? Sr?an D.

2012-01-01

354

Extracellular alveolar proteasome: possible role in lung injury and repair.  

UK PubMed Central (United Kingdom)

The ubiquitin-proteasome system is the major intracellular pathway for protein degradation in eukaryotes, and it also generates oligopeptides for antigen presentation. However, the 20S proteasome is also associated with the cell's outer membrane, and observations indicate its physiologic presence and biological activity in the extracellular alveolar space (i.e., in the epithelial lining fluid). Furthermore, its concentration is increased in the adult respiratory distress syndrome, acute lung injury, and other inflammatory lung disease. While its cellular origin, potential extracellular biological role, and mechanisms for extracellular transport are hitherto unclear, extracellular alveolar proteasomes could have a role in protein clearance, digestion of alveolar debris, modification or activation of secreted precursor proteins, and/or antigen processing, both in health and lung disease. This article summarizes available information on the extracellular alveolar proteasome and its possible role in alveolar maintainance, lung injury, and repair.

Sixt SU; Peters J

2010-02-01

355

Extrahepatic primary adrenal alveolar echinococcosis: a review.  

UK PubMed Central (United Kingdom)

Abstract Background: Primary echinococcosis, and especially primary alveolar echinococcosis (AE) is rare among adrenal lesions. Methods: We report a case of primary AE in a 28-year-old male with low backache and occasional upper limb pain lasting for six months, and review the pertinent but sparse literature on this disorder. Results: Evaluation of the patient revealed an abdominal mass as right adrenal AE. The adrenal gland is a rare extrahepatic site of occurrence of echinococcosis, and particularly of AE. Patients with adrenal echinococcosis usually have nonspecific clinical symptoms. Imaging examinations revealed clearly the features of AE and its surrounding pathology. Alveolar echinococcosis was seen as an inhomogeneous pseudotumor with irregular boundaries, an irregular central pseudocystic appearance, and infiltration into surrounding structures. On contrast-enhanced computed tomography, the periphery of the mass in AE may be enhanced and multicentric vesicles may be seen. Magnetic resonance imaging may show the multivesicular morphology of lesions. The definitive diagnosis of AE should be confirmed by pathologic or serologic examination. Radical surgical resection of the removable parasitic lesion, followed by anti-infective therapy with benzimidazoles, is the primary method for treating AE. Conclusion: Although primary adrenal AE is rare, it should be included in the differential diagnosis of adrenal masses, especially in regions where AE is endemic.

Chu ZG; Lv FJ; Zhu ZY; Ouyang Y

2013-08-01

356

Teaching alveolar ventilation with simple, inexpensive models  

Science.gov (United States)

When teaching and learning about alveolar ventilation with our class of 300 first-year medical students, we use four simple, inexpensive "models." The models, which encourage research-oriented learning and help our students to understand complex ideas, are distributed to the students before class. The students anticipate something new every day, and the models provide elements of surprise and physical examples and are designed to help students to understand 1) cohesive forces of the intrapleural space, 2) chest wall and lung dynamics, 3) alveolar volumes, and 4) regional differences in ventilation. Students are drawn into discussion by the power of learning that is associated with manipulating and thinking about objects. Specifically, the models encourage thinking about complex interactions, and the students appreciate manipulating objects and actually understanding how they work. Using models also allows us to show students how we think as well as what we know. Finally, students enjoy taking the models home to demonstrate to friends and family "how the body works" as well as use the models as future study aids.

PhD Stephen M. DiCarlo (Wayne State Univ Sch Med Dept of Physiology)

2008-08-07

357

Endostatin inhibits VEGF-A induced osteoclastic bone resorption in vitro  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Background Endostatin is a C-terminal fragment of collagen XVIII which is a component of basement membranes with the structural properties of both collagens and proteoglycans. Endostatin has a major role in angiogenesis which is intimately associated with bone development and remodeling. Signaling between the endothelial cells and the bone cells, for example, may have a role in recruitment of osteoclastic precursor cells. Our study aims at exploring a possibility that endostatin, either as a part of basement membrane or as a soluble molecule, may control osteoclastogenesis and osteoclastic bone resorption in vitro. Methods Rat pit formation assay was employed in order to examine the effect of endostatin alone or in combination with vascular endothelial growth factor-A (VEGF-A) on bone resorption in vitro. Effect of these agents on osteoclast differentiation in vitro was also tested. Osteoclastogenesis and the number of osteoclasts were followed by tartrate resistant acid phosphatase (TRACP) staining and resorption was evaluated by measuring the area of excavated pits. Results Endostatin inhibited the VEGF-A stimulated osteoclastic bone resorption, whereas endostatin alone had no effect on the basal resorption level in the absence of VEGF-A. In addition, endostatin could inhibit osteoclast differentiation in vitro independent of VEGF-A. Conclusion Our in vitro data indicate that collagen XVIII/endostatin can suppress VEGF-A induced osteoclastic bone resorption to the basal level. Osteoclastogenesis is also inhibited by endostatin. The regulatory effect of endostatin, however, is not critical since endostatin alone does not modify the basal bone resorption.

Sipola Annina; Nelo Katri; Hautala Timo; Ilvesaro Joanna; Tuukkanen Juha

2006-01-01

358

External apical root resorption in maxillary incisors in orthodontic patients: associated factors and radiographic evaluation.  

UK PubMed Central (United Kingdom)

PURPOSE: This study was performed to evaluate the incidence and degree of external apical root resorption of maxillary incisors after orthodontic treatment and to evaluate particular associated factors related to external apical root resorption. MATERIALS AND METHODS: The records and maxillary incisor periapical radiographs of 181 patients were investigated. Crown and root lengths were measured and compared on the pre- and post-treatment periapical radiographs. Crown length was measured from the center of the incisal edge to the midpoint of the cemento-enamel junction (CEJ). Root length was measured from the CEJ midpoint to the root apex. A correction factor for the enlargement difference was used to calculate root resorption. RESULTS: The periapical radiographs of 564 teeth showed that the average root resorption was 1.39±1.27 (8.24±7.22%) and 1.69±1.14 mm (10.16±6.78%) for the maxillary central and lateral incisors, respectively. The results showed that the dilacerated or pointed roots, maxillary premolar extraction cases, and treatment duration were highly significant factors for root resorption (p<0.001). Allergic condition was a significant factor at p<0.01. Age at the start of treatment, large overjet, and history of facial trauma were also factors significantly associated with root resorption (p<0.05). There was no statistically significant difference in root resorption among the factors of gender, overbite, tongue-thrusting habit, types of malocclusion, and types of bracket. CONCLUSION: These results suggested that orthodontic treatment should be carefully performed in pre-treatment extraction patients who have pointed or dilacerated roots and need long treatment duration.

Nanekrungsan K; Patanaporn V; Janhom A; Korwanich N

2012-09-01

359

Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis  

Directory of Open Access Journals (Sweden)

Full Text Available Abstract Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy, lipid-filled cells with impaired surfactant clearance and markedly reduced expression of the transcription factor peroxisome proliferator-activated receptor gamma (PPAR?) and the PPAR?-regulated ATP binding cassette (ABC) lipid transporter, ABCG1. An open label proof of concept Phase II clinical trial was conducted in PAP patients using rituximab, a chimeric murine-human monoclonal antibody directed against B lymphocyte specific antigen CD20. Rituximab treatment decreased anti-GM-CSF antibody levels in bronchoalveolar lavage (BAL) fluid, and 7/9 patients completing the trial demonstrated clinical improvement as measured by arterial blood oxygenation. Objectives This study sought to determine whether rituximab therapy would restore lipid metabolism in PAP alveolar macrophages. Methods BAL samples were collected from patients pre- and 6-months post-rituximab infusion for evaluation of mRNA and lipid changes. Results Mean PPAR? and ABCG1 mRNA expression increased 2.8 and 5.3-fold respectively (p???0.05) after treatment. Lysosomal phospholipase A2 (LPLA2) (a key enzyme in surfactant degradation) mRNA expression was severely deficient in PAP patients pre-treatment but increased 2.8-fold post-treatment. In supplemental animal studies, LPLA2 deficiency was verified in GM-CSF KO mice but was not present in macrophage-specific PPAR? KO mice compared to wild-type controls. Oil Red O intensity of PAP alveolar macrophages decreased after treatment, indicating reduced intracellular lipid while extracellular free cholesterol increased in BAL fluid. Furthermore, total protein and Surfactant protein A were significantly decreased in the BAL fluid post therapy. Conclusions Reduction in GM-CSF autoantibodies by rituximab therapy improves alveolar macrophage lipid metabolism by increasing lipid transport and surfactant catabolism. Mechanisms may involve GM-CSF stimulation of alveolar macrophage ABCG1 and LPLA2 activities by distinct pathways.

Malur Anagha; Kavuru Mani S; Marshall Irene; Barna Barbara P; Huizar Isham; Karnekar Reema; Thomassen Mary

2012-01-01

360

Resorption Rate Tunable Bioceramic: Si, Zn-Modified Tricalcium Phosphate  

Energy Technology Data Exchange (ETDEWEB)

This dissertation is organized in an alternate format. Several manuscripts which have already been published or are to be submitted for publication have been included as separate chapters. Chapter 1 is a general introduction which describes the dissertation organization and introduces the human bone and ceramic materials as bone substitute. Chapter 2 is the background and literature review on dissolution behavior of calcium phosphate, and discussion of motivation for this research. Chapter 3 is a manuscript entitled ''Si,Zn-modified tricalcium phosphate: a phase composition and crystal structure study'', which was published in ''Key Engineering Materials'' [1]. Chapter 4 gives more crystal structure details by neutron powder diffraction, which identifies the position for Si and Zn substitution and explains the stabilization mechanism of the structure. A manuscript entitled ''Crystal structure analysis of Si, Zn-modified Tricalcium phosphate by Neutron Powder Diffraction'' will be submitted to Biomaterials [2]. Chapter 5 is a manuscript, entitled ''Dissolution behavior and cytotoxicity test of Si, Zn-modified tricalcium phosphate'', which is to be submitted to Biomaterials [3]. This paper discusses the additives effect on the dissolution behavior of TCP, and cytotoxicity test result is also included. Chapter 6 is the study of hydrolysis process of {alpha}-tricalcium phosphate in the simulated body fluid, and the phase development during drying process is discussed. A manuscript entitled ''Hydrolysis of {alpha}-tricalcium phosphate in simulated body fluid and phase transformation during drying process'' is to be submitted to Biomaterials [4]. Ozan Ugurlu is included as co-authors in these two papers due to his TEM contributions. Appendix A is the general introduction of the materials synthesis, crystal structure and preliminary dissolution result. A manuscript entitled ''Resorption rate tunable bioceramic: Si and Zn-modified tricalcium phosphate'' was published in Ceramic Engineering and Science Proceedings (the 29th International Conference on Advanced Ceramics and Composites - Advances in Bioceramics and Biocomposites) [5].

Xiang Wei

2006-08-09

 
 
 
 
361

Consideraciones anatómicas del conducto alveolar inferior Anatomical considerations of the inferior alveolar canal  

Directory of Open Access Journals (Sweden)

Full Text Available INTRODUCCIÓN: el conocimiento de variantes anatómicas del conducto alveolar inferior es necesario para la realización de procedimientos que involucren la mandíbula. El objetivo fue determinar las relaciones y variaciones anatómicas del conducto alveolar inferior MÉTODOS: se hizo un estudio descriptivo, en 50 hemimandíbulas humanas secas, midiendo distancias del foramen mandibular con respecto a los bordes anterior, posterior, inferior y escotadura sigmoidea, las distancias del agujero mentoniano al borde basal y la cresta alveolar. Se hicieron cortes en la rama y el cuerpo, para determinar las relaciones con estructuras anatómicas próximas. RESULTADOS: el foramen mandibular fue encontrado en el 88% en el tercio medio de rama. La distancia del foramen a la escotadura fue 19,78 ± 3,3 mm, al borde anterior 17,46 ± 3,04, al borde posterior 12,2 ± 1,9 y al borde basal 26,4 ± 3,8 mm. La ubicación del conducto alveolar inferior a nivel de rama respecto a los bordes anterior, posterior, lateral y medial fue 11,1 ± 2,6, 15,8 ± 2,7, 3,5 ± 1,0 y 1,9 ± 0,7 mm respectivamente. En el cuerpo mandibular la distancias respecto a los bordes basal, lateral, medial y alveolar fueron 10,1 ± 2,3, 4,7 ± 1,4, 2,5 ± 1,0 y 13,7 ± 2,7 mm respectivamente distal al tercer molar, 7,6 ± 1,7, 6,4 ± 1,4, 2,8 ± 1,0 y 16,4 ± 2,2 mm distal al segundo molar, 7,1 ± 1,5, 6,1 ± 1,3, 2,6 ± 0,8 y 17,0 ± 2,3 mm distal al primer molar, y 7,9 ± 1,7, 4,7 ± 1,2, 3,4 ± 1,2 y 18.3±2.7 mm distal al segundo premolar. El diámetro fue 2,82 ± 0,6 mm. La distancia del agujero mentoniano al borde basal fue 14,2 ± 1,59 mm, a la cresta alveolar 15,97 ± 2,87 mm, y se relacionó con el segundo premolar. CONCLUSIONES: los datos obtenidos, si bien, no infieren en la totalidad de la población colombiana, confirma que existen variaciones anatómicas del conducto alveolar inferior diferentes a las descritas en otras poblaciones.INTRODUCTION: the knowledge of anatomical variations of the inferior alveolar canal is necessary for surgical procedures involving the mandible. The purpose was to determine the relationships and anatomical variations of the mandibular canal. METHODS: a descriptive study was performed using 50 dry mandibles measuring distances of the mandibular foramen with respect to the anterior posterior and lower borders and the sigmoid notch, distances from the mental foramen to the basal border and the alveolar crest. Cuts were done in ramus and body to determine the relationship with close anatomical structures. RESULTS: The mandibular foramen was found in 88% of the cases in the middle third of ramus. The distance from the foramen to the sigmoid notch was 19.78 ± 3.3 mm, to the anterior border was 17.46 ± 3.04 mm, to the posterior border was 12.2 ± 1.9 mm and to the inferior border was 26.4 ± 3.8 mm. The location of the inferior alveolar canal on the mandibular ramus with respect to the anterior, posterior, lateral and medial borders were 11.1 ± 2.6 mm, 15.8 ± 2.7 mm, 3.5 ±1.0 mm y 1.9 ± 0.7 mm respectively. On the mandibular body, the distances from the inferior alveolar canal to the inferior, lateral, medial and alveolar borders were 10.1 ± 2.3 mm, 4.7 ± 1.4 mm, 2.5 ± 1.0 mm and 13.7±2.7 mm respectively distal to the third molar, 7.6 ± 1.7 mm, 6.4 ± 1.4 mm, 2.8 ± 1.0 mm and 16.4 ± 2.2 mm distal to the second molar, 7.1 ± 1.5 mm, 6.1 ± 1.3 mm, 2.6 ± 0.8 mm and 17.0 ± 2.3 mm distal to the first molar, and 7.9 ± 1.7 mm, 4.7 ± 1.2 mm, 3.4 ± 1.2 mm and 18.3 ± 2.7 mm distal to the second bicuspid. The diameter was 2.82 ± 0.6 mm. The distance from the mental foramen to the inferior border was 14.2 ± 1.59 mm, to the alveolar crest was 15.97 ± 2.87 mm, and it was directly re

Omar Yamid Ruge Jiménez; Oscar Andrés Camargo Cañón; Yudy Patricia Ortiz

2009-01-01

362

Quantitative Diagnosis of Diffuse Alveolar Damage Using Extravascular Lung Water.  

UK PubMed Central (United Kingdom)

OBJECTIVES:: Acute respiratory distress syndrome is characterized by diffuse alveolar damage and increased extravascular lung water levels. However, there is no threshold extravascular lung water level that can indicate diffuse alveolar damage in lungs. We aimed to determine the threshold extravascular lung water level that discriminates between normal lungs and lungs affected with diffuse alveolar damage. DESIGN:: A retrospective analysis of normal lungs and lungs affected with diffuse alveolar damage was performed. SETTING:: Normal lung cases were taken from published data. Lung cases with diffuse alveolar damage were taken from a nationwide autopsy database. All cases of autopsy followed hospital deaths in Japan from more than 800 hospitals between 2004 and 2009; complete autopsies with histopathologic examinations were performed by board-certified pathologists authorized by the Japanese Society of Pathology. PATIENTS:: Normal lungs: 534; lungs with diffuse alveolar damage: 1,688. INTERVENTIONS:: We compared the postmortem weights of both lungs between the two groups. These lung weights were converted to extravascular lung water values using a validated equation. Finally, the extravascular lung water value that indicated diffuse alveolar damage was estimated using receiver operating characteristic analysis. MEASUREMENTS AND MAIN RESULTS:: The extravascular lung water values of the lungs showing diffuse alveolar damage were approximately two-fold higher than those of normal lungs (normal group, 7.3?±?2.8?mL/kg vs diffuse alveolar damage group 13.7?±?4.5?mL/kg; p < 0.001). An extravascular lung water level of 9.8?mL/kg allowed the diagnosis of diffuse alveolar damage to be established with a sensitivity of 81.3% and a specificity of 81.2% (area under the curve, 0.90; 95% CI, 0.88-0.91). An extravascular lung water level of 14.6?mL/kg represented a 99% positive predictive value. CONCLUSIONS:: This study may provide the first validated quantitative bedside diagnostic tool for diffuse alveolar damage. Extravascular lung water may allow the detection of diffuse alveolar damage and may support the clinical diagnosis of acute respiratory distress syndrome. The best extravascular lung water cut-off value to discriminate between normal lungs and lungs with d