Sample records for aids-defining events diagnosed

  1. Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy : not all AIDS-defining conditions are created equal

    Mocroft, Amanda; Sterne, Jonathan A C; Egger, Matthias; May, Margaret; Grabar, Sophie; Furrer, Hansjakob; Sabin, Caroline; Fatkenheuer, Gerd; Justice, Amy; Reiss, Peter; d'Arminio Monforte, Antonella; Gill, John; Hogg, Robert; Bonnet, Fabrice; Kitahata, Mari; Staszewski, Schlomo; Casabona, Jordi; Harris, Ross; Saag, Michael; Niesters, Bert


    BACKGROUND: The extent to which mortality differs following individual acquired immunodeficiency syndrome (AIDS)-defining events (ADEs) has not been assessed among patients initiating combination antiretroviral therapy. METHODS: We analyzed data from 31,620 patients with no prior ADEs who started co

  2. Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy

    Mocroft, Amanda; Sterne, Jonathan A C; Egger, Matthias;


    combination antiretroviral therapy. Cox proportional hazards models were used to estimate mortality hazard ratios for each ADE that occurred in >50 patients, after stratification by cohort and adjustment for sex, HIV transmission group, number of antiretroviral drugs initiated, regimen, age, date of starting......), 2880 ADEs were diagnosed in 2262 patients; 1146 patients died. The most common ADEs were esophageal candidiasis (in 360 patients), Pneumocystis jiroveci pneumonia (320 patients), and Kaposi sarcoma (308 patients). The greatest mortality hazard ratio was associated with non-Hodgkin's lymphoma (hazard...... ratio, 17.59; 95% confidence interval, 13.84-22.35) and progressive multifocal leukoencephalopathy (hazard ratio, 10.0; 95% confidence interval, 6.70-14.92). Three groups of ADEs were identified on the basis of the ranked hazard ratios with bootstrapped confidence intervals: severe (non...

  3. Variable Impact on Mortality of AIDS-Defining Events Diagnosed during Combination Antiretroviral Therapy: Not All AIDS-Defining Conditions Are Created Equal Antiretroviral Therapy Cohort Collaboration (ART-CC)

    A. Mocroft; J.A.C. Sterne; M. Egger; M. May; S. Grabar; H. Furrer; C. Sabin; G. Fatkenheuer; A. Justice; P. Reiss; A.d.A. Monforte; J. Gill; R. Hogg; F. Bonnet; M. Kitahata; S. Staszewski; J. Casabona; R. Harris; M. Saag


    Background. The extent to which mortality differs following individual acquired immunodeficiency syndrome (AIDS)-defining events (ADEs) has not been assessed among patients initiating combination antiretroviral therapy. Methods. We analyzed data from 31,620 patients with no prior ADEs who started co

  4. The risk of AIDS-defining events is decreasing over time in the German HIV-1 Seroconverter Cohort

    Altmann Mathias


    Full Text Available Abstract Background With ageing of the HIV-infected population, long-term exposure to treatment, varying adherence, emerging resistance and complications to therapies, effectiveness of Highly Active Antiretroviral Therapy (HAART needs to be monitored continuously at the population level. The German HIV-1 Seroconverter Cohort is a multi-centre, open, long-term observational cohort including patients with a known or reliably estimated date of HIV-infection i.e. last negative and first positive HIV antibody test within a maximum three-year interval or laboratory evidence of seroconversion. Our study aims to investigate survival improvements and changes in AIDS risk over calendar periods in the German HIV-1 Seroconverter Cohort. Methods Retrospective (for the pre-1997 period and prospective (since 1997 data from the German HIV-1 Seroconverter Cohort were used. Time from seroconversion to first AIDS-defining event over calendar periods was analysed by using Cox models adjusting for age at seroconversion, sex, transmission groups and short HIV test interval. Kaplan-Meier methods were used to determine expected survival (remaining AIDS-free by calendar period. Results 2162 seroconverters with 8976 person-years of observation were included in our analysis (up to 31.12.2010. A total of 196 first AIDSdefining events were reported. Two periods i.e. 19972000 and 2007-2010 were statistically associated with a reduction in the risk of AIDS, accounting for an overall reduction of 80%. Compared to1997-2000, hazard ratios were 2.6 (95%CI, 1.6-4.8; p=0.000 in pre-1997 and 0.5 (95%CI, 0.3-0.8; p=0.007 in 20072010. Independent risk factor for AIDS progression was age at seroconversion (HR, 1.3 per 10year-increase; p=0.001. Conclusion HAART effectiveness has improved in the German HIV-1-Seroconverter Cohort. The risk to develop AIDS decreased significantly in 19972000 and in 20072010. However, elderly may require particular monitoring in view of their faster

  5. Discrete event systems diagnosis and diagnosability

    Sayed-Mouchaweh, Moamar


    Discrete Event Systems: Diagnosis and Diagnosability addresses the problem of fault diagnosis of Discrete Event Systems (DES). This book provides the basic techniques and approaches necessary for the design of an efficient fault diagnosis system for a wide range of modern engineering applications. The different techniques and approaches are classified according to several criteria such as: modeling tools (Automata, Petri nets) that is used to construct the model; the information (qualitative based on events occurrences and/or states outputs, quantitative based on signal processing and data analysis) that is needed to analyze and achieve the diagnosis; the decision structure (centralized, decentralized) that is required to achieve the diagnosis. The goal of this classification is to select the efficient method to achieve the fault diagnosis according to the application constraints. This book focuses on the centralized and decentralized event based diagnosis approaches using formal language and automata as mode...

  6. Serious fatal and nonfatal non-AIDS-defining illnesses in Europe

    Mocroft, Amanda; Reiss, Peter; Gasiorowski, Jacek;


    BACKGROUND: Little is known about the incidence and risk factors for serious non-AIDS-defining events. METHODS: The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson re...

  7. An Event-based Approach to Hybrid Systems Diagnosability

    National Aeronautics and Space Administration — Diagnosability is an important issue in the design of diagnostic systems, because it helps identify whether sufficient information is available to distinguish all...

  8. Characteristics of non-AIDS-defining malignancies in the HAART era: a clinico-epidemiological study

    Dauby Nicolas


    Full Text Available Abstract Background Non-AIDS-defining malignancies (NADM are becoming a major cause of mortality in the era of highly active antiretroviral therapy. We wished to investigate the incidence, risks factors and outcome of NADM in an urban cohort. Methods We carried out an observational cohort of HIV patients with 12,746 patient-years of follow up between January 2002 and March 2009. Socio-demographics and clinical characteristics of patients diagnosed with NADM were retrospectively compared with the rest of the cohort. Causes of death and risk factors associated with NADM were assessed using logistic regression. Survival analyses were performed with Kaplan-Meier estimates. Cancer incidences were compared with those of the general population of the Brussels-Capital Region using the standardized incidence ratio (SIR. Results Forty-five NADM were diagnosed. At inclusion in the study, patients with NADM were older than patients without NADM (47 years vs. 38 years, p 3 vs. 224 cells/mm3, p 3 (OR 3.10; 95% CI 1.40-6.87 were associated with NADM. NADM were independently associated with higher mortality in the cohort (OR 14.79; 95% CI 6.95-31.49. Women with cancer, the majority of whom were of sub-Saharan African origin, had poorer survival compared with men. The SIR for both sexes were higher than expected for Hodgkin's lymphoma (17.78; 95% CI 6.49-38.71, liver cancers (8.73; 95% CI 2.35-22.34, anal cancers (22.67; 95% CI 8.28-49.34 and bladder cancers (3.79; 95% CI 1.02-9.70. The SIR for breast cancer was lower in women (SIR 0.29; 95% CI 0.06-0.85. Conclusions Age over 45 and a nadir CD4 count of less than 200 cells/mm3 were predictive of NADM in our cohort. Mortality was high, especially in sub-Saharan African women. Cancers with increased incidences were Hodgkin's lymphoma and anal, bladder and liver cancers in both sexes; women had a lower incidence of breast cancer.

  9. Factors Associated With Tuberculosis as an AIDS-Defining Disease in an Immigration Setting

    Martín, Vicente; García de Olalla, Patricia; Orcau, Angels; Caylà, Joan A.


    Background Immigration can affect the evolution of TB as an AIDS-defining disease (AIDS–TB). Methods The Barcelona AIDS register for 1994–2005 was analyzed, and the global characteristics of AIDS–TB and AIDS–non-TB cases were compared. The Mantel-Haenszel test was used in the trend analysis, and logistic regression was used in the multivariate analysis. Results Of the 3600 cases studied, 1130 had both AIDS and TB. A declining trend in AIDS–TB rates was observed in both sexes among both immigr...

  10. Impact of gender on the risk of AIDS-defining illnesses and mortality in Danish HIV-1-infected patients

    Thorsteinsson, Kristina; Ladelund, Steen; Jensen-Fangel, Søren; Larsen, Mette Vang; Johansen, Isik Somuncu; Katzenstein, Terese Lea; Pedersen, Gitte; Storgaard, Merete; Obel, Niels; Lebech, Anne-Mette


    time of HIV diagnosis MSM had a lower prevalence of AIDS compared to MSW. Women and MSW presented more often with tuberculosis and less often with AIDS-defining cancers compared to MSM. In the adjusted analyses we observed no differences in progression to AIDS. In the adjusted analyses of risk of death......Abstract Background: Gender differences in the risk of AIDS-defining illness (ADI) and mortality have been reported in the HIV-1-infected (HIV-positive) population, with conflicting findings. We aimed to assess the impact of gender on the risk of ADI and death in HIV-positive patients infected...

  11. Trends in AIDS-defining opportunistic illnesses incidence over 25 years in Rio de Janeiro, Brazil.

    Lara Coelho

    Full Text Available OBJECTIVES: To assess the temporal trends in incidence of AIDS-defining opportunistic illnesses in an urban cohort of a middle-income country. METHODS: HIV infected patients aged ≥ 18 years at cohort entry were included in this analysis. We calculated incidence rates per 1000 persons-years of observation for the first opportunistic illness presented after cohort enrollment, from 1987 to 2012. Trends for overall and specific opportunistic illnesses were tested and incidence rate ratios for the most recent calendar period were calculated as the ratio between the incidence rate observed in the most recent period of the study (2009-2012 and the incidence rate observed in first period of the study (1987-1990. RESULTS: Overall, 3378 patients were included in this analysis; of which 1119 (33% patients presented an opportunistic illness during follow up. Incidence rates of all opportunistic illnesses decreased over time, and the overall opportunistic illness incidence rates fell from 295.4/1000 persons-years in 1987-1990 to 34.6/1000 persons-years in 2009-2012. Tuberculosis, esophageal candidiasis, cerebral toxoplasmosis and Pneumocystis jirovecii pneumonia were the most incident opportunistic illnesses in the cohort. Tuberculosis had the highest incidence rate in the study period. The peak in tuberculosis incidence occurred in 1991-1993 (80.8/1000 persons-years. Cerebral toxoplasmosis was the third most incident opportunistic illness in the study, with a peak of incidence of 43.6/1000 persons-year in 1987-1990. CONCLUSIONS: All opportunistic illnesses incidence rates decreased over the years but they still occur in an unacceptable frequency. Tuberculosis co-infection among HIV-infected persists as an important challenge for health care professionals and policy makers in our setting. Impressively high rates of cerebral toxoplasmosis were found suggesting that its incidence among HIV-infected is linked to the high prevalence of Toxoplasma gondii

  12. Non-AIDS defining cancers in the D:A:D Study--time trends and predictors of survival

    Worm, Signe W; Bower, Mark; Reiss, Peter;


    Non-AIDS defining cancers (NADC) are an important cause of morbidity and mortality in HIV-positive individuals. Using data from a large international cohort of HIV-positive individuals, we described the incidence of NADC from 2004-2010, and described subsequent mortality and predictors of these....

  13. The association between combination antiretroviral adherence and AIDS-defining conditions at HIV diagnosis.

    Abara, Winston E; Xu, Junjun; Adekeye, Oluwatoyosi A; Rust, George


    Combination antiretroviral therapy (cART) has changed the clinical course of HIV. AIDS-defining conditions (ADC) are suggestive of severe or advanced disease and are a leading cause of HIV-related hospitalizations and death among people living with HIV/AIDS (PLWHA) in the USA. Optimal adherence to cART can mitigate the impact of ADC and disease severity on the health and survivability of PLWHA. The objective of this study was to evaluate the association between ADC at HIV diagnosis and optimal adherence among PLWHA. Using data from the 2008 and 2009 Medicaid data from 29 states, we identified individuals, between 18 and 49 years, recently infected with HIV and with a cART prescription. Frequencies and descriptive statistics were conducted to characterize sample. Univariate and multivariable Poisson regression analyses were employed to evaluate the association optimal cART adherence (defined as ≥ 95% study days covered by cART) and ADC at HIV diagnosis (≥1 ADC) were assessed. Approximately 17% of respondents with ADC at HIV diagnosis reported optimal cART adherence. After adjusting for covariates, respondents with an ADC at HIV diagnosis were less likely to report optimal cART adherence (adjusted prevalence ratio (APR) = 0.64, 95% confidence intervals (CI), 0.54-0.75). Among the covariates, males (APR=1.10, 95% CI, 1.02-1.19) compared to females were significantly more likely to report optimal adherence while younger respondents, 18-29 years (APR=0.67, 95% CI, 0.57-0.77), 30-39 years (APR=0.86, 95% CI, 0.79-0.95) compared to older respondents were significantly less likely to report optimal adherence. PLWHA with ADC at HIV diagnosis are at risk of suboptimal cART adherence. Multiple adherence strategies that include healthcare providers, case managers, and peer navigators should be utilized to improve cART adherence and optimize health outcomes among PLWHA with ADC at HIV diagnosis. Targeted adherence programs and services are required to address

  14. The Incidence of AIDS-Defining Illnesses at a Current CD4 Count ≥200 Cells/µL in the Post–Combination Antiretroviral Therapy Era

    Mocroft, A; Furrer, H J; Miro, J M;


    Few studies consider the incidence of individual AIDS-defining illnesses (ADIs) at higher CD4 counts, relevant on a population level for monitoring and resource allocation.......Few studies consider the incidence of individual AIDS-defining illnesses (ADIs) at higher CD4 counts, relevant on a population level for monitoring and resource allocation....

  15. Beta-blocker therapy and cardiac events among patients with newly diagnosed coronary heart disease

    Andersson, Charlotte; Shilane, David; Go, Alan S;


    BACKGROUND: The effectiveness of beta-blockers for preventing cardiac events has been questioned for patients who have coronary heart disease (CHD) without a prior myocardial infarction (MI). OBJECTIVES: The purpose of this study was to assess the association of beta-blockers with outcomes among...... patients with new-onset CHD. METHODS: We studied consecutive patients discharged after the first CHD event (acute coronary syndrome or coronary revascularization) between 2000 and 2008 in an integrated healthcare delivery system who did not use beta-blockers in the year before entry. We used time......-blockers among patients with new-onset CHD was associated with a lower risk of cardiac events only among patients with a recent MI....

  16. AIDS-defining illnesses among patients with HIV in Singapore, 1985 to 2001: results from the Singapore HIV Observational Cohort Study (SHOCS

    Bellamy Richard


    Full Text Available Abstract Background The objective was to describe the causes of initial and overall AIDS-defining disease episodes among HIV patients in Singapore. Methods A retrospective observational cohort study was performed of all adult patients seen at the national HIV referral center between 1985 and 2001. Data were extracted from the patients' records by ten trained healthcare workers. AIDS-defining conditions were established using predefined criteria. Results Among 1504 patients, 834 had experienced one or more AIDS-defining diseases. The most frequent causes of the initial AIDS-defining episode were Pneumocystis carinii pneumonia (35.7%, Mycobacterium tuberculosis (22.7% and herpes simplex (7.4%. In total 1742 AIDS-defining episodes occurred. The most frequent causes were Pneumocystis carinii pneumonia (25.1%, Mycobacterium tuberculosis (16.2% and cytomegalovirus retinitis (9.5%. Conclusions The most frequent causes of AIDS-defining illnesses in Singapore are similar to those reported in the West, prior to the introduction of anti-retroviral therapy. Opportunistic infections remain the most frequent AIDS-defining illnesses.

  17. Moist processes during MJO events as diagnosed from water isotopic measurements from the IASI satellite

    Tuinenburg, O. A.; Risi, C.; Lacour, J. L.; Schneider, M.; Wiegele, A.; Worden, J.; Kurita, N.; Duvel, J. P.; Deutscher, N.; Bony, S.; Coheur, P. F.; Clerbaux, C.


    This study aims to investigate some characteristics of the moist processes of the Madden-Julian oscillation (MJO), by making use of joint HDO (or δD) and H2O vapor measurements. The MJO is the main intraseasonal mode of the tropical climate but is hard to properly simulate in global atmospheric models. The joint use of δD-H2O diagnostics yields additional information compared to sole humidity measurements. We use midtropospheric Infrared Atmospheric Sounding Interferometer (IASI) satellite δD and H2O measurements to determine the mean MJO humidity and δD evolution. Moreover, by making use of high temporal resolution data, we determine the variability in this evolution during about eight MJO events from 2010 to 2012 (including those monitored during the DYNAMO (the Dynamics of the MJO), CINDY (Cooperative Indian Ocean Experiment in Y2011) campaign). These data have a higher spatiotemporal coverage than previous δD measurements, enabling the sampling of individual MJO events. IASI measurements over the Indian Ocean confirm earlier findings that the moistening before the precipitation peak of an MJO event is due to water vapor slightly enriched in HDO. There is then a HDO depletion around the precipitation peak that also corresponds to the moister environment. Most interevent variability determined in the current study occurs 5 to 10 days after the MJO event. In 75% of the events, humidity decreases while the atmosphere remains depleted. In a quarter of the events, humidity increases simultaneously with an increase in δD. After this, the advection of relatively dry and enriched air brings back the state to the mean. Over the maritime continent, δD-H2O cycles are more variable on time scales shorter than the MJO and the interevent variability is larger than over the Indian Ocean. The sequence of moistening and drying processes as revealed by the q-δD cycles can be used as a benchmark to evaluate the representation of moist processes in models. This is done here

  18. Augmenting defense-in-depth with the concepts of observability and diagnosability from Control Theory and Discrete Event Systems

    Defense-in-depth is a fundamental principle/strategy for achieving system safety. First conceptualized within the nuclear industry, defense-in-depth is the basis for risk-informed decisions by the U.S. Nuclear Regulatory Commission, and is recognized under various names in other industries (e.g., layers of protection in the Chemical industry). Accidents typically result from the absence or breach of defenses or violation of safety constraints. Defense-in-depth is realized by a diversity of safety barriers and a network of redundancies. However, this same redundancy and the intrinsic nature of defense-in-depth - the multiple lines of defense or 'protective layers' along a potential accident sequence - may enhance mechanisms concealing the occurrence of incidents, or that the system has transitioned to a hazardous state (accident pathogens) and that an accident is closer to being released. Consequently, the ability to safely operate the system may be hampered and the efficiency of defense-in-depth may be degraded or worse may backfire. Several accidents reports identified hidden failures or degraded observability of accidents pathogens as major contributing factors. In this work, we begin to address this potential theoretical deficiency in defense-in-depth by bringing concepts from Control Theory and Discrete Event Systems to bear on issues of system safety and accident prevention. We introduce the concepts of controllability, observability, and diagnosability, and frame the current understanding of system safety as a 'control problem' handled by defense-in-depth and safety barriers (or safety constraints). Observability and diagnosability are information-theoretic concepts, and they provide important complements to the energy model of accident causation from which the defense-in-depth principle derives. We formulate a new safety-diagnosability principle for supporting accident prevention, and propose that defense-in-depth be augmented with this principle, without

  19. Review of screening guidelines for non-AIDS-defining malignancies: evolving issues in the era of highly active antiretroviral therapy.

    Tyerman, Zachary; Aboulafia, David M


    HIV-associated morbidity and mortality have declined dramatically in the era of HAART. Through direct and indirect benefits of HAART, people with HIV/AIDS are living longer, developing less AIDS-defining cancers and more cancers commonly seen in the seronegative population. Herein, we review cancer screening strategies for people living with HIV and compare and contrast them with those of the general population. The most noticeable differences occur in anal and cervical cancer screening. Although anal cancer is uncommon in the general population, it is more prevalent in men who have sex with men and people at high risk for human papillomavirus infection, especially those infected with HIV. To address this, we recommend that a digital rectal exam and a visual inspection be performed annually. In addition, an anal Pap test should be performed soon after the diagnosis of HIV infection, with follow-up testing every six months until two normal tests. Abnormal cytological results are then investigated with high-resolution anoscopy and biopsy of suspicious lesions. In screening for cervical cancer, a Pap test should be performed during the anogenital exam after initial HIV diagnosis, with a second Pap six months later, then annually if the results are normal. A colposcopy should follow an abnormal result. Human papillomavirus testing as a screening method for cervical cancer in women with HIV can also be efficacious. In lung cancer screening, preliminary data suggest that low-dose computerized tomography may play an important role, but further research is needed. Screening for breast and colon cancer should follow guidelines for the general population. Early screening for prostate cancer based on a diagnosis of HIV lacks clear benefit. PMID:22297500

  20. AIDS defining disease: Disseminated cryptococcosis

    Roshan Anupama


    Full Text Available Disseminated cryptococcosis is one of the acquired immune deficiency syndrome defining criteria and the most common cause of life threatening meningitis. Disseminated lesions in the skin manifest as papules or nodules that mimic molluscum contagiosum (MC. We report here a human immunodeficiency virus positive patient who presented with MC like lesions. Disseminated cryptococcosis was confirmed by India ink preparation and histopathology. The condition of the patient improved with amphotercin B.

  1. Getting Diagnosed

    ... also for those with related disorders. How is Marfan syndrome diagnosed? getting_diagnosed.jpg A Marfan diagnosis ... spinal column). Is there a genetic test for Marfan syndrome? Genetic testing can provide helpful information in ...

  2. Clinical deterioration during antitubercular treatment at a district hospital in South Africa: the importance of drug resistance and AIDS defining illnesses.

    Dominique J Pepper

    Full Text Available BACKGROUND: Clinical deterioration on drug therapy for tuberculosis is a common cause of hospital admission in Africa. Potential causes for clinical deterioration in settings of high HIV-1 prevalence include drug resistant Mycobacterium tuberculosis (M.tb, co-morbid illnesses, poor adherence to therapy, tuberculosis associated-immune reconstitution inflammatory syndrome (TB-IRIS and subtherapeutic antitubercular drug levels. It is important to derive a rapid diagnostic work-up to determine the cause of clinical deterioration as well as specific management to prevent further clinical deterioration and death. We undertook this study among tuberculosis (TB patients referred to an adult district level hospital situated in a high HIV-1 prevalence setting to determine the frequency, reasons and outcome for such clinical deterioration. METHOD: A prospective observational study conducted during the first quarter of 2007. We defined clinical deterioration as clinical worsening or failure to stabilise after 14 or more days of antitubercular treatment, resulting in hospital referral. We collected data on tuberculosis diagnosis and treatment, HIV-1 status and antiretroviral treatment, and investigated reasons for clinical deterioration as well as outcome. RESULTS: During this period, 352 TB patients met inclusion criteria; 296 were admitted to hospital accounting for 17% of total medical admissions (n = 1755. Eighty three percent of TB patients (291/352 were known to be HIV-1 co-infected with a median CD4 count of 89cells/mm(3 (IQR 38-157. Mortality among TB patients admitted to hospital was 16% (n = 48. The median duration of hospital admission was 9.5 days (IQR 4-18, longer than routine in this setting (4 days. Among patients in whom HIV-1 status was known (n = 324, 72% of TB patients (n = 232 had an additional illness to tuberculosis; new AIDS defining illnesses (n = 80 were the most frequent additional illnesses (n = 208 in HIV-1 co-infected patients (n

  3. Use of a population-based survey to determine incidence of AIDS-defining opportunistic illnesses among HIV-positive persons receiving medical care in the United States

    Sullivan Patrick S


    Full Text Available Abstract Background Diagnosis of an opportunistic illness (OI in a person with HIV infection is a sentinel event, indicating opportunities for improving diagnosis of HIV infection and secondary prevention efforts. In the past, rates of OIs in the United States have been calculated in observational cohorts, which may have limited representativeness. Methods We used data from a 1998 population-based survey of persons in care for HIV infection to demonstrate the utility of population-based survey data for the calculation of OI rates, with inference to populations in care for HIV infection in three geographic areas: King County Washington, selected health districts in Louisiana, and the state of Michigan. Results The overall OI rate was 13.8 per 100 persons with HIV infection in care during 1998 (95% CI, 10.2–17.3. In 1998, an estimated 11.3% of all persons with HIV in care in these areas had at least one OI diagnosis (CI, 8.8–13.9. The most commonly diagnosed OIs were Pneumocystis jiroveci pneumonia (PCP (annual incidence 2.4 per 100 persons, CI 1.0–3.8 and cytomegalovirus retinitis (annual incidence 2.4 per 100 persons, CI 1.0–3.7. OI diagnosis rates were higher in Michigan than in the other two geographic areas, and were different among patients who were white, black and of other races, but were not different by sex or history of injection drug use. Conclusion Data from population-based surveys – and, in the coming years, clinical outcomes surveillance systems in the United States – can be used to calculate OI rates with improved generalizability, and such rates should be used in the future as a meaningful indicator of clinical outcomes in persons with HIV infection in care.

  4. Post-operative breast cancer patients diagnosed with skeletal metastasis without bone pain had fewer skeletal-related events and deaths than those with bone pain

    Koizumi Mitsuru


    Full Text Available Abstract Background Skeletal metastases are often accompanied by bone pain. To investigate the clinical meaning of bone pain associated with skeletal metastasis in breast cancer patients after surgery, we explored whether the presence of bone pain was due to skeletal-related events (SREs or survival (cause specific death, CSD, retrospectively. Methods Consecutive breast cancer patients undergoing surgery between 1988 and 1998 were examined for signs of skeletal metastasis until December 2006. Patients who were diagnosed as having skeletal metastasis were the subjects of this study. Bone scans were performed annually for 5, 7 or 10 years; they were also conducted if skeletal metastasis was suspected. Data concerning bone pain and tumor markers at the time of skeletal metastasis diagnosis, and data relating to various factors including tumors, lymph nodes and hormone receptors at the time of surgery, were investigated. The relationships between factors such as bone pain, SRE and CSD were analyzed using the Kaplan-Meier method and Cox's analysis. Results Skeletal metastasis occurred in 668 patients but the pain status of two patients was unknown, therefore 666 patients were included in the study. At the time of skeletal metastasis diagnosis 270 patients complained of pain; however, 396 patients did not. Analysis of data using Cox's and Kaplan-Meier methods demonstrated that patients without pain had fewer SREs and better survival rates than those with pain. Hazard ratios regarding SRE (base = patients without pain were 2.331 in univariate analysis and 2.243 in multivariate analysis. Hazard ratios regarding CSD (base = patients without pain were 1.441 in univariate analysis and 1.535 in multivariate analysis. Similar results were obtained when analyses were carried out using the date of surgery as the starting point. Conclusion Bone pain at diagnosis of skeletal metastasis was an indicator of increased SRE and CSD. However, these data did not

  5. Incidence of AIDS-Defining Opportunistic Infections and Mortality during Antiretroviral Therapy in a Cohort of Adult HIV-Infected Individuals in Hanoi, 2007-2014

    Tanuma, Junko; Lee, Kyu Ha; Haneuse, Sebastien; Matsumoto, Shoko; Nguyen, Dung Thi; Nguyen, Dung Thi Hoai; Do, Cuong Duy; Pham, Thuy Thanh; Nguyen, Kinh Van; Oka, Shinichi


    Background Although the prognosis for HIV-infected individuals has improved after antiretroviral therapy (ART) scale-up, limited data exist on the incidence of AIDS-defining opportunistic infections (ADIs) and mortality during ART in resource-limited settings. Methods HIV-infected adults in two large hospitals in urban Hanoi were enrolled to the prospective cohort, from October 2007 through December 2013. Those who started ART less than one year before enrollment were assigned to the survival analysis. Data on ART history and ADIs were collected retrospectively at enrollment and followed-up prospectively until April 2014. Results Of 2,070 cohort participants, 1,197 were eligible for analysis and provided 3,446 person-years (PYs) of being on ART. Overall, 161 ADIs episodes were noted at a median of 3.20 months after ART initiation (range 0.03–75.8) with an incidence 46.7/1,000 PYs (95% confidence interval [CI] 39.8–54.5). The most common ADI was tuberculosis with an incidence of 29.9/1,000 PYs. Mortality after ART initiation was 8.68/1,000 PYs and 45% (19/45) died of AIDS-related illnesses. Age over 50 years at ART initiation was significantly associated with shorter survival after controlling for baseline CD4 count, but neither having injection drug use (IDU) history nor previous ADIs were associated with poor survival. Semi-competing risks analysis in 951 patients without ADIs history prior to ART showed those who developed ADIs after starting ART were at higher risk of death in the first six months than after six months. Conclusion ADIs were not rare in spite of being on effective ART. Age over 50 years, but not IDU history, was associated with shorter survival in the cohort. This study provides in-depth data on the prognosis of patients on ART in Vietnam during the first decade of ART scale-up. PMID:26939050

  6. Events

    Igor V. Karyakin


    Full Text Available The 9th ARRCN Symposium 2015 was held during 21st–25th October 2015 at the Novotel Hotel, Chumphon, Thailand, one of the most favored travel destinations in Asia. The 10th ARRCN Symposium 2017 will be held during October 2017 in the Davao, Philippines. International Symposium on the Montagu's Harrier (Circus pygargus «The Montagu's Harrier in Europe. Status. Threats. Protection», organized by the environmental organization «Landesbund für Vogelschutz in Bayern e.V.» (LBV was held on November 20-22, 2015 in Germany. The location of this event was the city of Wurzburg in Bavaria.

  7. AIDS defining opportunistic infections in patients with high CD4 counts in the combination antiretroviral therapy (cART era: things ain’t what they used to be

    Valentin Gisler


    Full Text Available Introduction: According to reports from observational databases, classic AIDS-defining opportunistic infections (ADOIs occur in patients with CD4 counts above 500/µL on and off cART. Adjudication of these events is usually not performed. However, ADOIs are often used as endpoints, for example, in analyses on when to start cART. Materials and Methods: In the database, Swiss HIV Cohort Study (SHCS database, we identified 91 cases of ADOIs that occurred from 1996 onwards in patients with the nearest CD4 count >500/µL. Cases of tuberculosis and recurrent bacterial pneumonia were excluded as they also occur in non-immunocompromised patients. Chart review was performed in 82 cases, and in 50 cases we identified CD4 counts within six months before until one month after ADOI and had chart review material to allow an in-depth review. In these 50 cases, we assessed whether (1 the ADOI fulfilled the SHCS diagnostic criteria (, and (2 HIV infection with CD4 >500/µL was the main immune-compromising condition to cause the ADOI. Adjudication of cases was done by two experienced clinicians who had to agree on the interpretation. Results: More than 13,000 participants were followed in SHCS in the period of interest. Twenty-four (48% of the chart-reviewed 50 patients with ADOI and CD4 >500/µL had an HIV RNA 500/µL was the likely explanation for the ADOI in only seven cases (14%. Other reasons (Table 1 were ADOIs occurring during primary HIV infection in 5 (10% cases, unmasking IRIS in 1 (2% case, chronic HIV infection with CD4 counts 500/ µL, chronic HIV infection is the cause of ADOIs in only a minority of cases. Other immuno-compromising conditions are more likely explanations in one-third of the patients, especially in cases of candida oesophagitis. ADOIs in HIV patients with high CD4 counts should be used as endpoints only with much caution in studies based on observational databases.

  8. How Is Asthma Diagnosed?

    ... page from the NHLBI on Twitter. How Is Asthma Diagnosed? Your primary care doctor will diagnose asthma ... other disease may be causing your symptoms. Diagnosing Asthma in Young Children Most children who have asthma ...

  9. When to Monitor CD4 Cell Count and HIV RNA to Reduce Mortality and AIDS-Defining Illness in Virologically Suppressed HIV-Positive Persons on Antiretroviral Therapy in High-Income Countries: A Prospective Observational Study

    Caniglia, Ellen C.; Sabin, Caroline; Robins, James M.; Logan, Roger; Cain, Lauren E.; Abgrall, Sophie; Mugavero, Michael J.; Hernandez-Diaz, Sonia; Meyer, Laurence; Seng, Remonie; Drozd, Daniel R.; Seage, George R.; Bonnet, Fabrice; Dabis, Francois; Moore, Richard R.; Reiss, Peter; van Sighem, Ard; Mathews, William C.; del Amo, Julia; Moreno, Santiago; Deeks, Steven G.; Muga, Roberto; Boswell, Stephen L.; Ferrer, Elena; Eron, Joseph J.; Napravnik, Sonia; Jose, Sophie; Phillips, Andrew; Olson, Ashley; Justice, Amy C.; Tate, Janet P.; Bucher, Heiner C.; Egger, Matthias; Touloumi, Giota; Sterne, Jonathan A.; Costagliola, Dominique; Saag, Michael; Hernán, Miguel A.


    Objective: To illustrate an approach to compare CD4 cell count and HIV-RNA monitoring strategies in HIV-positive individuals on antiretroviral therapy (ART). Design: Prospective studies of HIV-positive individuals in Europe and the USA in the HIV-CAUSAL Collaboration and The Center for AIDS Research Network of Integrated Clinical Systems. Methods: Antiretroviral-naive individuals who initiated ART and became virologically suppressed within 12 months were followed from the date of suppression. We compared 3 CD4 cell count and HIV-RNA monitoring strategies: once every (1) 3 ± 1 months, (2) 6 ± 1 months, and (3) 9–12 ± 1 months. We used inverse-probability weighted models to compare these strategies with respect to clinical, immunologic, and virologic outcomes. Results: In 39,029 eligible individuals, there were 265 deaths and 690 AIDS-defining illnesses or deaths. Compared with the 3-month strategy, the mortality hazard ratios (95% CIs) were 0.86 (0.42 to 1.78) for the 6 months and 0.82 (0.46 to 1.47) for the 9–12 month strategy. The respective 18-month risk ratios (95% CIs) of virologic failure (RNA >200) were 0.74 (0.46 to 1.19) and 2.35 (1.56 to 3.54) and 18-month mean CD4 differences (95% CIs) were −5.3 (−18.6 to 7.9) and −31.7 (−52.0 to −11.3). The estimates for the 2-year risk of AIDS-defining illness or death were similar across strategies. Conclusions: Our findings suggest that monitoring frequency of virologically suppressed individuals can be decreased from every 3 months to every 6, 9, or 12 months with respect to clinical outcomes. Because effects of different monitoring strategies could take years to materialize, longer follow-up is needed to fully evaluate this question. PMID:26895294

  10. How Is COPD Diagnosed?

    ... page from the NHLBI on Twitter. How Is COPD Diagnosed? Your doctor will diagnose COPD based on ... Rate This Content: NEXT >> Featured Video What is COPD? 05/22/2014 Describes how COPD, or chronic ...

  11. HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignancies

    Monforte, Antonella d'Arminio; Abrams, Donald; Pradier, Christian;


    for 104 921 person-years. We used Poisson regression models to identify factors independently associated with deaths from ADM and nADM. Analyses of factors associated with mortality due to nADM were repeated after excluding nADM known to be associated with a specific risk factor. RESULTS: Three...... two-fold higher latest CD4 cell count was associated with a halving of the risk of ADM mortality. Other predictors of an increased risk of ADM mortality were homosexual risk group, older age, a previous (non-malignancy) AIDS diagnosis and earlier calendar years. Predictors of an increased risk of n...

  12. Chagasic meningoencephalitis: case report of a recently included AIDS-defining illness in Brazil Meningoencefalite chagásica: relato de caso de doença recentemente incluida como indicativa de AIDS no Brasil

    Geraldine Madalosso


    Full Text Available Recently, reactivation of Chagas disease (meningoencephalitis and/or myocarditis was included in the list of AIDS-defining illnesses in Brazil. We report a case of a 52-year-old patient with no history of previous disease who presented acute meningoencephalitis. Direct examination of blood and cerebrospinal fluid (CSF showed Trypanosoma cruzi. CSF culture confirmed the diagnosis. Serological assays for T. cruzi and human immunodeficiency virus (HIV were positive. Despite treatment with benznidazol and supportive measures, the patient died 24 hours after hospital admission. In endemic areas, reactivation of Chagas disease should always be considered in the differential diagnosis of meningoencephalitis among HIV-infected patients, and its presence is indicative of AIDS.Recentemente, a reagudização da doença de Chagas (meningoencefalite e/ou miocardite foi incluída na lista de doenças indicativas de aids no Brasil. Os autores relatam o caso de um paciente de 52 anos de idade, natural de área rural da Bahia e procedente de uma área urbana de São Paulo, sem história de doenças prévias e que apresentou meningoencefalite aguda. As sorologias e pesquisas parasitológicas diretas no sangue e no liquido cefalorraquideano (LCR demonstraram presença de Trypanosoma cruzi, confirmando-se o diagnóstico mediante cultura do LCR. O teste rápido assim como os ELISA e Western Blot diagnosticaram infecção pelo vírus da imunodeficiência humana (HIV. Apesar do tratamento com benzonidazole e as medidas de suporte, o paciente faleceu 24 horas depois da admissão hospitalar. Em áreas endêmicas, a reagudização da doença de Chagas deve ser sempre considerada no diagnóstico diferencial das meningoencefalites e sua presença em pacientes com infecção pelo HIV é indicativa de aids.

  13. Diagnosing Sleep Disorders

    ... of this page please turn JavaScript on. Feature: Sleep Disorders Diagnosing Sleep Disorders Past Issues / Summer 2015 Table of Contents Depending ... several possible tests when trying to diagnose a sleep disorder: Sleep history and sleep log If you believe ...

  14. Differential diagnoses to MS

    Horwitz, Henrik; Friis, Tina; Modvig, Signe;


    of 643 patients were included in the study. Apart from ON, the most frequent diagnoses were tumors (n = 15), ischemic or hypertensive neuropathies (n = 13), and retinal or choroid disorders (n = 9). Six patients were diagnosed with neuromyelitis optica. Rarer causes of visual loss were infections (n...

  15. Diagnosing Psoriatic Arthritis

    ... to find out more! Email * Zipcode Diagnosing Psoriatic Arthritis Psoriatic arthritis can develop slowly with mild symptoms, or it ... severe. Early recognition, diagnosis and treatment of psoriatic arthritis can help prevent or limit extensive joint damage ...

  16. Diagnosing Delirium by Telephone

    Marcantonio, Edward R.; Sm,; Michaels, Mary; Resnick, Neil M.


    To determine whether delirium can be diagnosed by telephone, we interviewed 41 subjects aged 65 years or older 1 month after repair of hip fracture, first by telephone and then face-to-face. Interviews included the modified telephone Mini-Mental State Examination and the Delirium Symptom Interview. Delirium was diagnosed using the Confusion Assessment Method diagnostic algorithm, and the telephone results were compared with the face-to-face results (the “gold standard”). Of 41 subjects, 6 wer...

  17. Diagnosing gestational diabetes

    Ryan, E. A.


    The newly proposed criteria for diagnosing gestational diabetes will result in a gestational diabetes prevalence of 17.8%, doubling the numbers of pregnant women currently diagnosed. These new diagnostic criteria are based primarily on the levels of glucose associated with a 1.75-fold increased risk of giving birth to large-for-gestational age infants (LGA) in the Hyperglycemia Adverse Pregnancy Outcome (HAPO) study; they use a single OGTT. Thus, of 23,316 pregnancies, gestational diabetes wo...

  18. Diagnosing Functional Seizures in Children and Adolescent

    Wichaidit, Bianca Taaning; Rask, Charlotte Ulrikka; Ostergaard, John R


    Functional seizures (FS) is a condition where the child experiences seizure-like events, without abnormal electrical discharge as measured by EEG, and with high risk of misdiagnosis. Diagnosing FS contains: 1) video-EEG, 2) anamnestic evaluation, focusing on the presence of psychosocial stressors...

  19. How a Stroke Is Diagnosed

    ... News About Neurology Image Library Search The Internet Stroke Center Patients & Families About Stroke Stroke Diagnosis Stroke ... Diagnosis » How a Stroke is Diagnosed How a Stroke is Diagnosed How a Stroke is Diagnosed Lab ...

  20. Diagnosing and Treating Acute Bronchitis

    ... Lung Disease Lookup > Acute Bronchitis Diagnosing and Treating Acute Bronchitis It is important to get your questions about ... Symptoms that last a few weeks How Is Acute Bronchitis Diagnosed? Healthcare providers diagnose acute bronchitis by asking ...

  1. Understanding Prostate Cancer: Newly Diagnosed

    ... Wellness PCF Spotlight Glossary African American Men Understanding Prostate Cancer Newly Diagnosed Newly Diagnosed Staging the Disease Issues ... you care about has recently been diagnosed with prostate cancer, this section will help guide you through the ...

  2. Being publicly diagnosed

    Konradsen, Hanne; Lillebaek, Troels; Wilcke, Jon Torgny Rostrup;


    INTRODUCTION: Tuberculosis (TB) is a disease which affects people worldwide, but there is knowledge lacking about patients' experiences in low-prevalence and high-income countries. AIM: To provide a theoretical framework for the process of being diagnosed with tuberculosis in a Danish setting. ME...

  3. Diagnosing pulmonary embolism

    Khosla Rahul


    Full Text Available Pulmonary embolism (PE is a common, treatable, highly lethal emergency, which despite advances in diagnostic testing, remains an under diagnosed killer. The mortality rate of diagnosed and treated pulmonary embolism ranges from 3-8%, but increases to about 30% in untreated pulmonary embolism. PE is a part of the spectrum of venousthromboembolic disease and most pulmonary emboli have their origin from clots in the iliac, deep femoral, or popliteal veins. Nonspecific clinical signs and symptoms with low sensitivity and specificity of routine tests such as arterial blood gas, chest roentgenogram and electrocardiogram make the diagnosis of PE very challenging for the clinician. Pulmonary angiography is the gold standard diagnostic test, but this technique is invasive, expensive, not readily available and labor intensive. Diagnostic strategies have revolved around establishing clinical probabilities based on predictive models, then ruling in or ruling out the diagnosis of PE with various tests. The aim of this article was to review the literature and present an evidence- based medicine approach to diagnosis of pulmonary embolism.

  4. How Is Pulmonary Hypertension Diagnosed?

    ... from the NHLBI on Twitter. How Is Pulmonary Hypertension Diagnosed? Your doctor will diagnose pulmonary hypertension (PH) ... To Look for the Underlying Cause of Pulmonary Hypertension PH has many causes, so many tests may ...

  5. How Is Cystic Fibrosis Diagnosed?

    ... page from the NHLBI on Twitter. How Is Cystic Fibrosis Diagnosed? Doctors diagnose cystic fibrosis (CF) based on ... tested to see whether the baby has CF. Cystic Fibrosis Carrier Testing People who have one normal CFTR ...

  6. Diagnosing Dementia--Positive Signs

    ... Navigation Bar Home Current Issue Past Issues Diagnosing Dementia—Positive Signs Past Issues / Fall 2007 Table of ... easy, affordable blood test that could accurately diagnose Alzheimer's disease (AD)—even before symptoms began to show? Researchers ...

  7. How Is Muscular Dystrophy Diagnosed?

    ... Information Clinical Trials Resources and Publications How is muscular dystrophy diagnosed? Skip sharing on social media links Share this: Page Content The first step in diagnosing muscular dystrophy (MD) is a visit with a health care ...

  8. Ankle Fractures Often Not Diagnosed

    ... Not Diagnosed A A A | Print | Share Ankle Fractures Often Not Diagnosed Long-term complications result from ... patients: Total ankle replacements--similar to hip and knee replacements--were once reserved for geriatric patients but ...

  9. Diagnoses and interventions in podiatry.

    Zuijderduin, W.M.; Dekker, J


    In the present study a quantitative description is given of diagnoses and interventions in podiatry. Data are used from a survey on podiatry practice in The Netherlands. Data have been recorded by 36 podiatrists on 897 patients. Information was gathered on patient characteristics, the medical diagnoses, the podiatry diagnoses (impairments and disabilities), treatment goals derived from these diagnoses, and interventions. Impairments were recorded in nearly all patients. The interrelationship ...

  10. Analysis of epidemiological and clinical characteristics of patients admitted diagnosed with acute ischemic cerebrovascular event in internal medicine services and neurology of the Hospital Mexico in March 2013 to March 2014

    Records of 100 patients were revised with diagnosis of ischemic cerebrovascular event in the neurology and internal medicine at the Hospital Mexico since March 2013 to March 2014. A total of 46 patients were men and 54 were women. The overall mean age was 69 years, for men have been 66 years and for women from 71. Patients of all provinces were entered main of San Jose with 56% followed by 19% Alajuela. The hospital management by specialty was distributed 60% to internal medicine and 40% neurology. The risk factors most frequently found were: hypertension 85%, diabetes mellitus 40%, smoking 35%, and dyslipidemia 35%. Overweight was observed in 23% of patients and 22% obese. As for the initial clinical manifestations documented in the first physical examination, the 6 most frequently found have been: faciobrachiocrural hemiparesis 60%, delirium 22%, dysarthria 22%, headache 20%, nausea and/or vomiting 17% and aphasia 15%. A total of 13% of patients have altered the consciousness and 5% have required ventilatory support for first 24 hours of evolution. 27% of patients have arrived within the first 3 hours of onset of symptoms, 11% between 3 to 4.5 hours and the remaining 62% beyond 4.5 hours of duration. 70% of patients have had 1 or more comorbidities prior to the event, the top 5 have been: ischemic heart disease 31%, 29% atrial fibrillation, cerebrovascular disease 19%, 16% chronic kidney disease and congestive heart failure by 12%. Regarding the topographic classification of stokes, 16% were TACI, PACI 46%, 27% LACI and POCI only 11%. The average NIHSS scale has been 9 points to admission, 10 to 48 hours and 6 points at the time of discharge. Regarding brain scan on admission to 98% of the patients were performed while that between 48-72 hours alone to 74%. The most common initial tomographic CT findings have been: 49% lucency of more than 1/3 of middle cerebral artery territory, without alteration 46%, 8% cerebral edema data and 8% midline deviation. Hemorrhagic

  11. Numerical simulation of heavy precipitation events using mesoscale weather forecast models. Validation with radar data and diagnosis of the atmospheric moisture budget; Numerische Simulation von Starkniederschlagsereignissen mit mesoskaligen Wettervorhersagemodellen. Ueberpruefung mit Radar-Daten und Diagnose der atmosphaerischen Wasserbilanz

    Keil, C.


    Convective precipitation systems contribute substantially to the summertime rainfall maximum in the northern Alpine region. The capability of mesoscale weather forecast models in capturing such heavy precipitation events is investigated. The complementary application of so far hardly used areal radar data and conventional rain gauge observations enables a case-study-type evaluation of summertime precipitation episodes. Different rainfall episodes are simulated with the former operational model (DM, meshsize 14 km) of Deutscher Wetterdienst (DWD). The influence of the horizontal resolution and the parameterization of moist convection is subsequently studied with a higher resolution atmospheric model (MC2, meshsize 2 km). Diagnostic studies on the atmospheric water budget regarding the rainfall episode, which instigated the Oder-flood in summer 1997, allow an examination of the origin of the moisture and the genesis of the copious precipitation. (orig.) [German] Konvektive Niederschlagssysterne tragen im Nordalpenraum wesentlich zum sommerlichen Niederschlagsmaximum bei. Die Faehigkeit mesoskaliger Wettervorhersagemodelle, solche Starkniederschlagsereignisse zu erfassen, wird in dieser Arbeit untersucht. Durch den komplementaeren Gebrauch von, bisher kaum genutzten, flaechendeckenden Radardaten und konventionellen Niederschlagsmessungen des Bodenmessnetzes werden Modellergebnisse sommerlicher Niederschlagssysteme fallstudienhaft detailliert ueberprueft. Fuer verschiedene Starkniederschlagsereignisse werden dazu Modellsimulationen mit dem in den 90er Jahren operationellen Modell (DM, Maschenweite 14 km) des Deutschen Wetterdienstes (DWD) durchgefuehrt. Zur Untersuchung des Einflusses der horizontalen Maschenweite und der Niederschlagsparametrisierung werden ferner numerische Simulationen mit einem hoeher aufloesdenden Atmosphaerenmodell (MC2, Maschenweite 2 km) behandelt. Anhand diagnostischer Untersuchungen der atmosphaerischen Wasserbilanz laesst sich ausserdem die

  12. Diagnosable structured logic array

    Whitaker, Sterling (Inventor); Miles, Lowell (Inventor); Gambles, Jody (Inventor); Maki, Gary K. (Inventor)


    A diagnosable structured logic array and associated process is provided. A base cell structure is provided comprising a logic unit comprising a plurality of input nodes, a plurality of selection nodes, and an output node, a plurality of switches coupled to the selection nodes, where the switches comprises a plurality of input lines, a selection line and an output line, a memory cell coupled to the output node, and a test address bus and a program control bus coupled to the plurality of input lines and the selection line of the plurality of switches. A state on each of the plurality of input nodes is verifiably loaded and read from the memory cell. A trusted memory block is provided. The associated process is provided for testing and verifying a plurality of truth table inputs of the logic unit.

  13. Study of phosphorylation events for cancer diagnoses and treatment.

    López Villar, Elena; Madero, Luis; A López-Pascual, Juan; C Cho, William


    The activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation and survival, is orchestrated by protein kinases via phosphorylation. A critical issue is the study of the mechanisms of cancer cells for the development of more effective drugs. With the application of the new proteomic technologies, together with the advancement in the sequencing of the human proteome, patients will therefore be benefited by the discovery of novel therapeutic and/or diagnostic protein targets. Furthermore, the advances in proteomic approaches and the Human Proteome Organization (HUPO) have opened a new door which is helpful in the identification of patients at risk and towards improving current therapies. Modification of the signaling-networks via mutations or abnormal protein expression underlies the cause or consequence of many diseases including cancer. Resulting data is used to reveal connections between genes proteins and compounds and the related molecular pathways for underlining disease states. As a delegate of HUPO, for human proteome on children assays and studies, we, at Hospital Universitario Niño Jesús, are seeking to support the human proteome in this context. Clinical goals have to be clearly established and proteomics experts have to set up the appropriate proteomic strategy, which coupled to bioinformatics will make it possible to achieve new therapies for patients with poor prognosis. We envision to combine our up-coming data to the HUPO organization in order to support international efforts to advance the cure of cancer disease. PMID:26055493

  14. A Knowledge Based System for Diagnosing Nosocomial Infections

    Landry, Gail; Beyt, B. Eugene; Delcambre, Lois M.L.


    This paper describes the design, implementation, and evaluation of a knowledge based prototype for diagnosing nosocomial infections. The prototype uses a consultative session to diagnose three major types of infection: urinary tract infection, bacteremia, and surgical wound infection. The system evaluates the results of microbiology and laboratory testing, includes rules based on clinical events, and determines onset dates. The prototype was implemented in Prolog and was tested for its abilit...

  15. How Is Aplastic Anemia Diagnosed?

    ... from the NHLBI on Twitter. How Is Aplastic Anemia Diagnosed? Your doctor will diagnose aplastic anemia based on your medical and family histories, a ... your primary care doctor thinks you have aplastic anemia, he or she may refer you to a ...

  16. How Is Polycythemia Vera Diagnosed?

    ... page from the NHLBI on Twitter. How Is Polycythemia Vera Diagnosed? Polycythemia vera (PV) may not cause signs or symptoms for ... to find out whether you have primary polycythemia (polycythemia vera) or secondary polycythemia. Your medical history and physical ...

  17. How Is Lactose Intolerance Diagnosed?

    ... Information Clinical Trials Resources and Publications How is lactose intolerance diagnosed? Skip sharing on social media links Share ... based on symptoms alone whether a person has lactose intolerance or another condition. 2 Many common health problems ...

  18. How Is Atrial Fibrillation Diagnosed?

    ... Atrial Fibrillation » How Is Atrial Fibrillation Diagnosed? Explore Atrial Fibrillation What Is... Types Other Names Causes Who Is at Risk Signs & Symptoms Diagnosis Treatments Prevention Living With Clinical Trials Links Related Topics Arrhythmia ...

  19. Nursing diagnoses in overweight adolescents

    Raphaela Santos do Nascimento Rodrigues; Ana Márcia Tenório de Souza Cavalcanti; Telma Marques da Silva


    This study aimed to identify nursing diagnoses in overweight adolescents from public schools, according to the International Classification for Nursing Practice. A population-based cross-sectional study that investigated the socio-demographic, behavioural and psychological characteristics of adolescents aged from 10 to 14 years. 11 nursing diagnoses were identified: "Risk of overweight", "Risk of impaired adolescent development", "Risk of insecurity in parental role performance", "Risk of the...

  20. Diagnosing faults in autonomous robot plan execution

    Lam, Raymond K.; Doshi, Rajkumar S.; Atkinson, David J.; Lawson, Denise M.


    A major requirement for an autonomous robot is the capability to diagnose faults during plan execution in an uncertain environment. Many diagnostic researches concentrate only on hardware failures within an autonomous robot. Taking a different approach, the implementation of a Telerobot Diagnostic System that addresses, in addition to the hardware failures, failures caused by unexpected event changes in the environment or failures due to plan errors, is described. One feature of the system is the utilization of task-plan knowledge and context information to deduce fault symptoms. This forward deduction provides valuable information on past activities and the current expectations of a robotic event, both of which can guide the plan-execution inference process. The inference process adopts a model-based technique to recreate the plan-execution process and to confirm fault-source hypotheses. This technique allows the system to diagnose multiple faults due to either unexpected plan failures or hardware errors. This research initiates a major effort to investigate relationships between hardware faults and plan errors, relationships which were not addressed in the past. The results of this research will provide a clear understanding of how to generate a better task planner for an autonomous robot and how to recover the robot from faults in a critical environment.

  1. Nursing diagnoses in overweight adolescents

    Raphaela Santos do Nascimento Rodrigues


    Full Text Available This study aimed to identify nursing diagnoses in overweight adolescents from public schools, according to the International Classification for Nursing Practice. A population-based cross-sectional study that investigated the socio-demographic, behavioural and psychological characteristics of adolescents aged from 10 to 14 years. 11 nursing diagnoses were identified: "Risk of overweight", "Risk of impaired adolescent development", "Risk of insecurity in parental role performance", "Risk of the family impaired ability to manage diet regime", "Risk of impaired ability to manage diet regime", "Risk of lack of knowledge of dietary regime", "Risk of excess food intake", "Risk of negative self-image", "Risk of low self-esteem", "Risk of impaired social well-being" and "Impaired exercise pattern". These diagnoses reflect the multifactorial nature of obesity, highlighting the need for interdisciplinary and intersectoral articulation of nursing interventions for prevention and control of overweight.

  2. Diagnosing and Treating Hantavirus Pulmonary Syndrome (HPS)

    ... . Hantavirus Share Compartir Diagnosing and Treating Hantavirus Pulmonary Syndrome (HPS) Diagnosing HPS Diagnosing HPS in ... is no specific treatment, cure, or vaccine for hantavirus infection. However, we do know that if infected ...

  3. Immunological methods for diagnosing neurocysticercosis

    Kuhn, R.E.; Estrada, J.J.; Grogl, M.


    A method is described for diagnosing active human neurocysticercosis by detecting the presence of at least one Taenia solium larval antigen in cerebrospinal fluid, which comprises: contacting cerebrospinal fluid from a human to be diagnosed with a solid support, wherein the support binds with a Taenia solium larval antigen if present, contacting the support with a first antibody, wherein the first antibody binds with a larval Taenia solium antigen if present in the cerebrospinal fluid, contacting the solid support with a detectable second antibody which will bind with the first antibody, and detecting the second antibody bound to the support.

  4. Advice for the Newly Diagnosed

    ... De-Risking Successes PD Therapeutics Conference Sponsored Prizes Data Science Challenge Robert A. Pritzker Prize Bachmann-Strauss Prize ... need newly-diagnosed Parkinson’s patients.) In 2011, the Food and Drug Administration (FDA) approved a specialized imaging ...

  5. Diagnoses and interventions in podiatry.

    Zuijderduin, W.M.; Dekker, J.


    In the present study a quantitative description is given of diagnoses and interventions in podiatry. Data are used from a survey on podiatry practice in The Netherlands. Data have been recorded by 36 podiatrists on 897 patients. Information was gathered on patient characteristics, the medical diagno

  6. How Is Fanconi Anemia Diagnosed?

    ... from the NHLBI on Twitter. How Is Fanconi Anemia Diagnosed? People who have Fanconi anemia (FA) are born with the disorder. They may ... questions about: Any personal or family history of anemia Any surgeries you’ve had related to the ...


    Cajnko, Katja


    In a highly developed consumer society saturated with advertisements, events are getting more and more popular as a marketing communication element. In literature events are mentioned in connection with tourism and event management, but recent research shows an increase in using events as an element of the marketing communication mix. Two of the most important advantages of events are: it is the consumer's own decision to attend the events and they can offer to the consumer a positive experie...

  8. Event management

    Urban, Zdeněk


    The thesis deals with event management and is formally divided into three sections. The first section provides the theoretical basis for the practical part. It primarily defines the terms event, event management and event marketing. The theoretical part proceeds from the general introduction to more detailed examination of the issue, which includes the classification of event marketing within the marketing and communication mix of the company, the typology of events and explanation of various...

  9. Event management

    Jandová, Dita


    The thesis deal with event management. For better insight into this field event management is described on case of management of conference. The thesis has three main parts. In the theoretical part there are definitions of terms like event management, conference and other related terms. Further chapters are concerned with the position of event management in the communication mix, typologies of events and mostly with the crucial aspects of event management. In the second part of the thesis the...

  10. Event management

    Šubrtová, Veronika


    This bachelor thesis on the topic event management develops this concept, focuses mainly on the creation of the event and its application in practice. Management, event and event management are described in the theoretical section. The importace of event management in the marketing communications mix is shown subsequently and especially the creation of the event is more detailed described. This is then reflected in the practical part of the thesis, in which the awards gala is planed and orga...

  11. Event management

    Grebíková, Kristýna


    The thesis in theoretical part focuses on the concepts of event management and their interaction. The theoretical part focuses on the creation of event planning and marketing strategies, typology of events, and provides a situational analysis, objectives events, defines the target group, plan the resources, establish a budget and will focus on event controlling. The practical part carries theory into practice and deals with the organization of the event in the company TON in Chile. Based on a...

  12. Hospital-diagnosed dementia and suicide

    Erlangsen, Annette; Zarit, Steven H; Conwell, Yeates


    OBJECTIVE: The current study aims to examine the risk of suicide in persons diagnosed with dementia during a hospitalization and its relationship to mood disorders. DESIGN: Event-history analysis using time-varying covariates. SETTING: Population-based record linkage. PARTICIPANTS: All individual...... for older adults. Preventive measures should focus on suicidal ideation after initial diagnosis but also acknowledge that suicides can occur well after a dementia diagnosis has been established....... who are aged 70 or older with dementia have a threefold higher risk than persons with no dementia. The time shortly after diagnosis is associated with an elevated suicide risk. The risk among persons with dementia remains significant when controlling for mood disorders. As many as 26% of the men...... and 14% of the women who died by suicide died within the first 3 months after being diagnosed whereas 38% of the men and 41% of the women died more than 3 years after initial dementia diagnosis. CONCLUSIONS: Dementia, determined during hospitalization, was associated with an elevated risk of suicide...

  13. Event marketing

    Pham, Quynh Trang


    This study aims to analyze event-marketing activities of the small firm and propose new events. At first the theoretical part describes marketing and communication mix and then especially planning and development of event marketing campaign. Research data were collected by the method of survey to propose the new events. Randomly selected customers were asked to fill the questionnaire. Its results were integrated into the proposal of the new events. The interview was realized with the owner of...

  14. Event management

    Pavléková, Markéta


    The main theme of the work is event management, which deals with the social events of various types. Event as a mean of communication is a common part of business strategy today and the organization became a separate industry. Procedures how to implement successful event are the essential part of the work. Organizationally demanding activity of event managers, which includes planning, organizing, staffing, leadership and control is supported by marketing activities, which are described in the...

  15. Event management

    Michňa, Michal


    The theoretical part of this thesis deals with event management in general. The stress of its theoretical part is put on relation between event management and the other communication channels usually used by marketing experts in a firm. There is also described a confrontation of event management with processes which are basically used in project management. The theoretical part is mainly concerned with event management and organisation of events. There is a deep description of its prepara...

  16. Event management

    Vomáčková, Kateřina


    This thesis deals with event management from theory to practice. First part of the thesis consists of literature review of this topic – from definition of basic terms, through event management’s classification in marketing of a company, to description of different stages of event management process. The second part of the thesis is based on practice – an agency that organized for the third year an event focusing on children and sport, is presented here. Last year of this event including...

  17. Diagnosing GORD in respiratory medicine

    Chris James Timms


    Full Text Available Gastroesophageal reflux disease is increasing in prevalence and is associated with several lung diseases such as asthma and COPD. Current diagnostic methods are imperfect, being insensitive, nonspecific, expensive or invasive. An accurate diagnosis of GORD can aid effective treatment with a significant clinical impact. Novel methods such as exhaled breath condensate analysis and electronic nose technology have the potential to improve the accuracy of diagnosing GORD.

  18. Diagnosing GORD in Respiratory Medicine

    Timms, Chris J.; Yates, Deborah H; Thomas, Paul S.


    Gastroesophageal reflux disease (GORD) is increasing in prevalence and is highly associated with several lung diseases such as asthma and COPD. Current diagnostic methods are imperfect, being insensitive, non-specific, expensive, or invasive. An accurate diagnosis of GORD can aid effective treatment and have significant clinical impact. Novel methods such as exhaled breath condensate analysis and electronic nose technology have the potential to improve the accuracy of diagnosing GORD.

  19. Event management

    Palkosková, Barbora


    The diploma thesis deals with a term of event management and its connection to the event marketing. First part of the work focuses on terms that are superior to event management and those are marketing and marketing mix of 4P´s. Communication mix is than separated into smaller parts, defining the position of event marketing and management among them. Accent is put on the current possibilities of typology and separation of event and its practical use. Issue of events is connected to the...

  20. Verification of Opacity and Diagnosability for Pushdown Systems

    Koichi Kobayashi


    Full Text Available In control theory of discrete event systems (DESs, one of the challenging topics is the extension of theory of finite-state DESs to that of infinite-state DESs. In this paper, we discuss verification of opacity and diagnosability for infinite-state DESs modeled by pushdown automata (called here pushdown systems. First, we discuss opacity of pushdown systems and prove that opacity of pushdown systems is in general undecidable. In addition, a decidable class is clarified. Next, in diagnosability, we prove that under a certain assumption, which is different from the assumption in the existing result, diagnosability of pushdown systems is decidable. Furthermore, a necessary condition and a sufficient condition using finite-state approximations are derived. Finally, as one of the applications, we consider data integration using XML (Extensible Markup Language. The obtained result is useful for developing control theory of infinite-state DESs.


    I Pt Agus Suryantara P


    Full Text Available Fungi disease  on skin is often occur at Indonesia because it is a tropic country that has hot climate and also correlate wit bad hygiene.  Dermatofitosis is fungi disease on the keratinizing tissue and differentiate as many class such as Tinea Corporis or TineaCruris. Tinea fascialis include in this form. The diagnose this disease from anamnesis,clinical manifetation, and also test result from the tissue. Management for thistineacomprise to topical and systemic. The important one in management this disease isprevention  management include in control of skin dryness.

  2. Event management

    Štefl, Petr


    This bachelor thesis on the topic of event management deals with planning, organizing, managing, monitoring and implementation of special social events, termed event. It explains what they mean by this term we can imagine and as you can in terms of typology to distinguish events. Literature review consists of the acquired theoretical knowledge in management, project management and marketing. It describes the principles and procedure in place, we should keep the successful organization of ...

  3. Event management

    Strýhalová, Veronika


    The Diploma thesis is focused on the Event management company, which organizes a big family minded sport day and describes its activity plan. The thesis consists three main parts, the first – the teoretic part specifices proffesional terms about an event management. This part also describes different event forms which are focused on the right selection and final strategy, the following control of financial situation and event overall what is in general a part of marketing mixture. The second ...

  4. Event management

    Stružková, Tereza


    The main objective of this thesis is based on theoretical knowledge and analysis of the actual implementation event action in congress centre of 4*hotel. Asesment of importance, correctnesand effectivess of the vatious procedures of organizin events and create new complete schematic principle of organizin events Implementation actions will be considered from two sides – from side of the company organizer and from the side of event managment coordinator. All the outputs of these two aspect ...

  5. How Is Alpha-1 Antitrypsin Deficiency Diagnosed?

    ... Alpha-1 Antitrypsin Deficiency Diagnosed? Alpha-1 antitrypsin (AAT) deficiency usually is diagnosed after you develop a ... related to the condition. Your doctor may suspect AAT deficiency if you have signs or symptoms of ...

  6. How Is Thrombotic Thrombocytopenic Purpura Diagnosed?

    ... Diagnosed? Your doctor will diagnosis thrombotic thrombocytopenic purpura (TTP) based on your medical history, a physical exam, and test results. If TTP is suspected or diagnosed, a hematologist will be ...

  7. How Are Obesity and Overweight Diagnosed?

    ... Information Clinical Trials Resources and Publications How are obesity & overweight diagnosed? Skip sharing on social media links ... and Blood Institute. (2012). How are overweight and obesity diagnosed? Retrieved August 8, 2012, from http://www. ...

  8. [Munchausen disease diagnosed ten years after debut].

    Mrgan, Monija; Taasti, Lena Merete


    Munchausen disease is difficult to diagnose especially because it is often an exclusion diagnosis. We present a case of skin ulcers in a young woman, who was eventually diagnosed with Munchausen disease. PMID:23992908

  9. How Is a Heart Attack Diagnosed?

    ... from the NHLBI on Twitter. How Is a Heart Attack Diagnosed? Your doctor will diagnose a heart attack ... This Content: NEXT >> Featured Video What is a heart attack? 05/22/2014 Describes how a heart attack ...

  10. Transplantvaskulopathie - Pathophysiologie, Diagnose und Therapie

    Pölzl G


    Full Text Available Die Transplantvaskulopathie (CAV ist die häufigste Todesursache im Langzeitverlauf nach Herztransplantation. Sowohl immunologische als auch nicht-immunologische Faktoren sind für die Entwicklung der meist konzentrischen, diffusen, überwiegend fibrösen Intimahyperplasie verantwortlich. Die klinische Symptomatik ist unspezifisch, regelmäßige Kontrolluntersuchungen sind daher erforderlich. Im Gegensatz zur konventionellen Koronarangiographie ermöglicht der intravaskuläre Ultraschall die frühzeitige Diagnose und Quantifizierung der Erkrankung und damit einen raschen Therapiebeginn. Dabei spielen die konsequente Einstellung kardiovaskulärer Risikofaktoren, die immunsuppressive Therapie und die Zytomegalie-Prophylaxe eine wichtige Rolle. Bei schweren Verlaufsformen kommen die perkutane Koronarintervention, seltener die Bypassoperation und in ausgewählten Fällen die Retransplantation zum Einsatz.

  11. Event Modeling

    Bækgaard, Lars


    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics.We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...... temporarily from bookcases to borrowers. When we characterize events as change agents we focus on concepts like transactions, entity processes, and workflow processes....

  12. Event Modeling

    Bækgaard, Lars


    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics. We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...... temporarily from bookcases to borrowers. When we characterize events as change agents we focus on concepts like transactions, entity processes, and workflow processes....

  13. Diagnosing Common Benign Skin Tumors.

    Higgins, James C; Maher, Michael H; Douglas, Mark S


    Patients will experience a wide range of skin growths and changes over their lifetime. Family physicians should be able to distinguish potentially malignant from benign skin tumors. Most lesions can be diagnosed on the basis of history and clinical examination. Lesions that are suspicious for malignancy, those with changing characteristics, symptomatic lesions, and those that cause cosmetic problems may warrant medical therapy, a simple office procedure (e.g., excision, cryosurgery, laser ablation), or referral. Acrochordons are extremely common, small, and typically pedunculated benign neoplasms. Simple scissor or shave excision, electrodesiccation, or cryosurgery can be used for treatment. Sebaceous hyperplasia presents as asymptomatic, discrete, soft, pale yellow, shiny bumps on the forehead or cheeks, or near hair follicles. Except for cosmesis, they have no clinical significance. Lipomas are soft, flesh-colored nodules that are easily moveable under the overlying skin. Keratoacanthomas are rapidly growing, squamoproliferative benign tumors that resemble squamous cell carcinomas. Early simple excision is recommended. Pyogenic granuloma is a rapidly growing nodule that bleeds easily. Treatment includes laser ablation or shave excision with electrodesiccation of the base. Dermatofibromas are an idiopathic benign proliferation of fibroblasts. No treatment is required unless there is a change in size or color, bleeding, or irritation from trauma. Epidermal inclusion cysts can be treated by simple excision with removal of the cyst and cyst wall. Seborrheic keratoses and cherry angiomas generally do not require treatment. PMID:26447443

  14. Trauma, comorbidity, and mortality following diagnoses of severe stress and adjustment disorders: a nationwide cohort study.

    Gradus, Jaimie L; Antonsen, Sussie; Svensson, Elisabeth; Lash, Timothy L; Resick, Patricia A; Hansen, Jens Georg


    Longitudinal outcomes following stress or trauma diagnoses are receiving attention, yet population-based studies are few. The aims of the present cohort study were to examine the cumulative incidence of traumatic events and psychiatric diagnoses following diagnoses of severe stress and adjustment disorders categorized using International Classification of Diseases, Tenth Revision, codes and to examine associations of these diagnoses with all-cause mortality and suicide. Data came from a longitudinal cohort of all Danes who received a diagnosis of reaction to severe stress or adjustment disorders (International Classification of Diseases, Tenth Revision, code F43.x) between 1995 and 2011, and they were compared with data from a general-population cohort. Cumulative incidence curves were plotted to examine traumatic experiences and psychiatric diagnoses during the study period. A Cox proportional hazards regression model was used to examine the associations of the disorders with mortality and suicide. Participants with stress diagnoses had a higher incidence of traumatic events and psychiatric diagnoses than did the comparison group. Each disorder was associated with a higher rate of all-cause mortality than that seen in the comparison cohort, and strong associations with suicide were found after adjustment. This study provides a comprehensive assessment of the associations of stress disorders with a variety of outcomes, and we found that stress diagnoses may have long-lasting and potentially severe consequences. PMID:26243737

  15. Novel approaches in diagnosing tuberculosis

    Kolk, Arend H. J.; Dang, Ngoc A.; Kuijper, Sjoukje; Gibson, Tim; Anthony, Richard; Claassens, Mareli M.; Kaal, Erwin; Janssen, Hans-Gerd


    The WHO declared tuberculosis (TB) a global emergency. An estimated 8-9 million new cases occur each year with 2-3 million deaths. Currently, TB is diagnosed mostly by chest-X ray and staining of the mycobacteria in sputum with a detection limit of 1x104 bacteria /ml. There is an urgent need for better diagnostic tools for TB especially for developing countries. We have validated the electronic nose from TD Technology for the detection of Mycobacterium tuberculosis by headspace analysis of 284 sputum samples from TB patients. We used linear discriminant function analysis resulting in a sensitivity of 75% a specificity of 67% and an accuracy of 69%. Further research is still required to improve the results by choosing more selective sensors and sampling techniques. We used a fast gas chromatography- mass spectrometry method (GC-MS). The automated procedure is based on the injection of sputum samples which are methylated inside the GC injector using thermally assisted hydrolysis and methylation (THM-GC-MS). Hexacosanoic acid in combination with tuberculostearic acid was found to be specific for the presence of M. tuberculosis. The detection limit was similar to microscopy. We found no false positives, all microscopy and culture positive samples were also found positive with the THM-GC-MS method. The detection of ribosomal RNA from the infecting organism offers great potential since rRNA molecules outnumber chromosomal DNA by a factor 1000. It thus may possible to detect the organism without amplification of the nucleic acids (NA). We used a capture and a tagged detector probe for the direct detection of M. tuberculosis in sputum. So far the detection limit is 1x106 bacteria / ml. Currently we are testing a Lab-On-A-Chip Interferometer detection system.

  16. Pulmonale Hypertension, Pathophysiologie, Diagnose, Therapie

    Lang I


    Full Text Available Die pulmonale Hypertension (PH ist ein Syndrom, bestehend aus Atemnot bei Belastung, Brustschmerzen und Synkopen und beruht auf einer Steigerung des pulmonal-arteriellen Druckes und Erhöhung des Lungengefäßwiderstandes. Durch einen progressiven Verlauf kommt es beim Unbehandelten innerhalb von zwei bis drei Jahren nach Diagnosestellung zu Rechtsherzversagen und Tod. Die Erkrankung ist eine Lungengefäßerkrankung. In allen Schichten der Gefäßwand finden sich pathologische Veränderungen. Das Lungengefäßendothel zeigt prokoagulatorische Eigenschaften, die glatte Gefäßmuskulatur ist depolarisiert und Kalzium-überladen, die Adventitia zeigt eine Überexpression von Metalloproteinasen und Elastasen als Ausdruck eines aktiven vaskulären Remodelings. Basierend auf dem Konzept, daß Vasokonstriktion und thrombotischer Verschluß der Widerstandsgefäße der Lunge den Krankheitsprozeß beschleunigen, werden derzeit Vasodilatation und Antikoagulierung als Therapie eingesetzt. Noch vor wenigen Jahren wurde die medikamentöse Therapie der PH nur als Überbrückung zur Lungen- oder Herz-Lungen-Transplantation betrachtet. Allerdings könnten Vasodilatatoren oder Vasodilatator-Kombinationstherapien in Zukunft eine Alternative zur Lungentransplantation darstellen. Vor Beginn einer Vasodilatatortherapie wird in einem standardisierten Austestungsverfahren die individuelle Gefäßreaktivität festgestellt. Schlüssel für die Diagnostik ist die Abgrenzung der chronisch thromboembolischen pulmonalen Hypertension (CTEPH von allen anderen Formen. Die CTEPH ist die einzige PH, die durch eine pulmonale Thromboendarterektomie geheilt werden kann. Dieser Artikel bietet eine kurze aktuelle Zusammenfassung über Klassifikation der verschiedenen Formen von PH, Pathologie und Pathobiologie, Risikofaktoren, Genetik, Diagnose und Therapien.


    Zacks, Jeffrey M.; Swallow, Khena M.


    One way to understand something is to break it up into parts. New research indicates that segmenting ongoing activity into meaningful events is a core component of ongoing perception, with consequences for memory and learning. Behavioral and neuroimaging data suggest that event segmentation is automatic and that people spontaneously segment activity into hierarchically organized parts and sub-parts. This segmentation depends on the bottom-up processing of sensory features such as movement, an...

  18. Event management

    Plechatý, Josef


    This theses focused on Event management is divided into two parts. First part includes theoretical knowledge while the second part is strictly practical. The first part is focused on marketing, its importance and basic terms. The chapter about marketing is followed by marketing mix, which is shortly characterized and divided into advertisement, sales promotion, public relations and other elements of the communication mix. The last part is a detailed study of Event marketing which includes th...

  19. From experience: applying the risk diagnosing methodology

    Keizer, Jimme A.; Halman, Johannes I.M.; Song, Michael


    No risk, no reward. Companies must take risks to launch new products speedily and successfully. The ability to diagnose and manage risks is increasingly considered of vital importance in high-risk innovation. This article presents the Risk Diagnosing Methodology (RDM), which aims to identify and eva

  20. Therapy of Newly Diagnosed Follicular Lymphoma

    Jason R. Westin


    Full Text Available Newly diagnosed follicular lymphoma is relatively common and can be effectively treated with several differing approaches. Although the disease is often considered incurable, it is highly responsive to therapy when indicated. This review discusses the indications for treatment, risk stratification systems, treatment options with supporting clinical trial data, and expected therapeutic outcomes in newly diagnosed follicular lymphoma.

  1. Critical thinking and accuracy of nurses' diagnoses.

    Lunney, Margaret


    Interpretations of patient data are complex and diverse, contributing to a risk of low accuracy nursing diagnoses. This risk is confirmed in research findings that accuracy of nurses' diagnoses varied widely from high to low. Highly accurate diagnoses are essential, however, to guide nursing interventions for the achievement of positive health outcomes. Development of critical thinking abilities is likely to improve accuracy of nurses' diagnoses. New views of critical thinking serve as a basis for critical thinking in nursing. Seven cognitive skills and ten habits of mind are identified as dimensions of critical thinking for use in the diagnostic process. Application of the cognitive skills of critical thinking illustrates the importance of using critical thinking for accuracy of nurses' diagnoses. Ten strategies are proposed for self-development of critical thinking abilities. PMID:14649031

  2. Event management

    Myslivcová, Hana Bc.


    V práci je popsán teoretický postup při pořádání eventů, který vychází ze zásad projektového řízení. Tyto postupy jsou také aplikovány v praktické realizaci eventu. Následuje výzkum aktuálních trendů v event managementu a výzkum cílových skupin s pomocí dat MML/TGI.

  3. Topography's event

    Munck Petersen, Rikke

    The aim of the paper is first to discuss how horizon and scale can be understood, secondly how they differ and what they might have in common? If topography can be seen as a way of working with these relations experiences, creations and latencies? Thirdly if diagrams and diagrammatology can bring...... space formation - to stimulate and elaborate the event of conception and topological thinking....

  4. Validation studies of nursing diagnoses in neonatology

    Pavlína Rabasová


    Full Text Available Aim: The objective of the review was the analysis of Czech and foreign literature sources and professional periodicals to obtain a relevant comprehensive overview of validation studies of nursing diagnoses in neonatology. Design: Review. Methods: The selection criterion was studies concerning the validation of nursing diagnoses in neonatology. To obtain data from relevant sources, the licensed professional databases EBSCO, Web of Science and Scopus were utilized. The search criteria were: date of publication - unlimited; academic periodicals - full text; peer-reviewed periodicals; search language - English, Czech and Slovak. Results: A total of 788 studies were found. Only 5 studies were eligible for content analysis, dealing specifically with validation of nursing diagnoses in neonatology. The analysis of the retrieved studies suggests that authors are most often concerned with identifying the defining characteristics of nursing diagnoses applicable to both the mother (parents and the newborn. The diagnoses were validated in the domains Role Relationship; Coping/Stress tolerance; Activity/Rest, and Elimination and Exchange. Diagnoses represented were from the field of dysfunctional physical needs as well as the field of psychosocial and spiritual needs. The diagnoses were as follows: Parental role conflict (00064; Impaired parenting (00056; Grieving (00136; Ineffective breathing pattern (00032; Impaired gas exchange (00030; and Impaired spontaneous ventilation (00033. Conclusion: Validation studies enable effective planning of interventions with measurable results and support clinical nursing practice.

  5. Prevalence of Diagnosed Cancer According to Duration of Diagnosed Diabetes and Current Insulin Use Among U.S. Adults With Diagnosed Diabetes

    Li, Chaoyang; Zhao, Guixiang; Okoro, Catherine A; Wen, Xiao-Jun; Ford, Earl S.; Balluz, Lina S


    OBJECTIVE To estimate the prevalence of diagnosed cancer according to duration of diagnosed diabetes and current insulin use among U.S. adults with diagnosed diabetes. RESEARCH DESIGN AND METHODS We analyzed data from 25,964 adults aged ≥18 years with diagnosed diabetes who participated in the 2009 Behavioral Risk Factor Surveillance System. RESULTS After adjustment for potential confounders, we found that the greater the duration of diagnosed diabetes, the higher the prevalence of diagnosed ...

  6. How Is Chronic Lymphocytic Leukemia Diagnosed?

    ... this protein generally indicate a more advanced CLL. Bone marrow tests Blood tests are often enough to diagnose ... is called an incisional biopsy . Lumbar puncture (or spinal tap) This procedure is used to take samples ...

  7. How Are Lung Carcinoid Tumors Diagnosed?

    ... Research Get Involved Find Local ACS Learn About Cancer » Lung Carcinoid Tumor » Detailed Guide » How are lung carcinoid tumors diagnosed? Share this Page Close Push escape to close share window. Print ...

  8. How Is von Willebrand Disease Diagnosed?

    ... of your von Willebrand factor. The test helps your doctor diagnose what type of VWD you have. Platelet function test. This test measures how well your platelets are working. You may have these tests ...

  9. How Is a Heart Murmur Diagnosed?

    ... Is a Heart Murmur Diagnosed? Doctors use a stethoscope to listen to heart sounds and hear heart ... your heart or your child's heart with a stethoscope to find out whether a murmur is innocent ...

  10. How Is Breast Cancer in Men Diagnosed?

    ... disturbing. Some places will give you headphones with music to block this noise out. MRIs are also expensive, but insurance plans generally pay for them in some situations, such as once cancer is diagnosed. MRI machines are quite common, but ...

  11. How Do Health Care Providers Diagnose Endometriosis?

    ... and Publications How do health care providers diagnose endometriosis? Skip sharing on social media links Share this: ... way to be sure of the diagnosis of endometriosis. The most common surgery is called laparoscopy (pronounced ...

  12. At få en diagnose

    Olesen, Birgitte Ravn; Jansbøl, Kirsten

    I dette hæfte ligger fokus på døvblindblevnes fortællinger om at have et handicap uden at kende sin diagnose og om at håndtre at få diagnosen RP eller Usher syndrom. Det er karakteristisk for fortællingerne, at det har stor betydning - hvornår i livet, man får sin diagnose - under hvilke omstændi......I dette hæfte ligger fokus på døvblindblevnes fortællinger om at have et handicap uden at kende sin diagnose og om at håndtre at få diagnosen RP eller Usher syndrom. Det er karakteristisk for fortællingerne, at det har stor betydning - hvornår i livet, man får sin diagnose - under hvilke...

  13. Diagnosing Diabetes and Learning about Prediabetes

    ... Size: A A A Listen En Español Diagnosing Diabetes and Learning About Prediabetes There are several ways ... mg/dl – 199 mg/dl Preventing Type 2 Diabetes You will not develop type 2 diabetes automatically ...

  14. Diagnosing Asthma in Very Young Children

    ... Listen Español Text Size Email Print Share Diagnosing Asthma in Babies & Toddlers Page Content Article Body One ... family with recurrent bronchitis or sinus problems. When Asthma is Not the Cause Your pediatrician will listen ...

  15. Challenges in diagnosing tuberculosis in children

    Rahman, Nadia; Pedersen, Karin Kæreby; Rosenfeldt, Vibeke;


    Clinical investigations of childhood tuberculosis (TB) are challenged by the paucibacillary nature of the disease and the difficulties in obtaining specimens. We investigated the challenges in diagnosing TB in children in a low-incidence country.......Clinical investigations of childhood tuberculosis (TB) are challenged by the paucibacillary nature of the disease and the difficulties in obtaining specimens. We investigated the challenges in diagnosing TB in children in a low-incidence country....

  16. Diagnosing Infectious Mononucleosis: Avoiding the Pitfalls

    McSherry, J. A.


    Infectious mononucleosis may be diagnosed with confidence only when Hoagland's diagnostic criteria have been met. The illness must be compatible with the known clinical features of infectious mononucleosis; there should be absolute and relative lymphocytosis on differential white cell count; there should be more than 20% atypical lymphocytes and serological tests should be positive—either a Paul-Bunnell Davidsohn or a rapid slide test for heterophil antibody. Failure to diagnose this common v...

  17. Nursing diagnoses in women deprived of freedom

    Izabelle de Freitas Ferreira; Tatiane Gomes Guedes; Sheila Coelho Ramalho Vasconcelos Morais; José Cristovam Martins Vieira; Marcelle Guimarães de Mello; Francisca Márcia Pereira Linhares


    Objective: to analyze the nursing diagnoses profile of women deprived of freedom, using the International Classification for Nursing® Practice version 1.0. Methods: a descriptive study, conducted with 186 women deprived of freedom. Nursing Diagnoses were extrapolated based on the clinical data of the participants, collected through a structured form and clinical reasoning. Results: there were 44 nursing diagnostic statements, among the most common, there were: infection risk (70.9%); fluid in...

  18. Diagnosis, medium-range predictability and impacts of the North Atlantic Oscillation (NAO): the occurrence of extreme wind speed and precipitation events over central Europe. Final report; Diagnose, mittelfristige Vorhersagbarkeit und Auswirkungen der Nordatlantischen Oszillation (NAO): Das Auftreten extremer Windgeschwindigkeiten und Gebietsniederschlaege ueber Mitteleuropa. Abschlussbericht ueber die wissenschaftlichen Ergebnisse 1998 - 2000

    Klawa, M.; Wefers, J.; Ulbrich, U.; Speth, P.


    In this research Rhine-floods at Cologne and severe storm events in Germany are investigated. Special emphasis is put on a possible link between these events and the North Atlantic Oscillation (NAO). Over Germany intensive storm events are identified with a statistical model based on gust-speed observations and NCEP-Reanalysis data. The model-output is validated to insurance data. It is found out that storm-probability in Germany increases with positive monthly and seasonal NAO-index values. Evaluations of scenario runs - simulating an intensification of greenhouse gas forcing due to anthropogenic emissions - show a trend to more positive phases of the NAO. For the future an increased number of severe storms is expected. An influence of the NAO on the Rhine floods can be stated. At slightly positive values of monthly NAO the frequency of floods is increased. Nevertheless, possible changes in the future NAO do have only a small influence on the number of events, but the impact on the flood-genesis has to be taken into account. (orig.) [German] In dieser Studie werden Hochwasser am Rhein bei Koeln und schadenintensive Sturmereignisse in Deutschland untersucht. Insbesondere wird der Zusammenhang zwischen der Nordatlantischen Oszillation (NAO) und diesen Extremereignissen erarbeitet. Schadenintensive Sturmereignisse werden mit Hilfe eines statistischen Sturmschadenmodells basierend auf Boeen und NCEP-Reanalysedaten identifiziert. Das Modell wurde zuvor an Schadendaten der Versicherungsindustrie verifiziert. Auf Basis der identifizierten Stuerme wird die Auftretenshaeufigkeit intensiver Ereignisse in Deutschland in Abhaengigkeit der NAO untersucht. Es wird festgestellt, dass bei positiven Phasen der Nordatlantischen Oszillation auf monatlicher bis saisonaler Zeitskala im Winterhalbjahr ein deutlich erhoehtes Auftretensrisiko intensiver Sturmereignisse in Deutschland besteht. Auswertungen von Klimaszenarienlaeufen deuten auf einen verstaerkten Trend zu hoeheren Phasen

  19. Event Index - a LHCb Event Search System

    Ustyuzhanin, Andrey; Kazeev, Nikita; Redkin, Artem


    LHC experiments generate up to $10^{12}$ events per year. This paper describes Event Index - an event search system. Event Index's primary function is quickly selecting subsets of events from a combination of conditions, such as the estimated decay channel or stripping lines output. Event Index is essentially Apache Lucene optimized for read-only indexes distributed over independent shards on independent nodes.

  20. Simulating events

    Ferretti, C.; Bruzzone, L. [Techint Italimpianti, Milan (Italy)


    The Petacalco Marine terminal on the Pacific coast in the harbour of Lazaro Carclenas (Michoacan) in Mexico, provides coal to the thermoelectric power plant at Pdte Plutarco Elias Calles in the port area. The plant is being converted from oil to burn coal to generate 2100 MW of power. The article describes the layout of the terminal and equipment employed in the unloading, coal stacking, coal handling areas and the receiving area at the power plant. The contractor Techint Italimpianti has developed a software system, MHATIS, for marine terminal management which is nearly complete. The discrete event simulator with its graphic interface provides a real-type decision support system for simulating changes to the terminal operations and evaluating impacts. The article describes how MHATIS is used. 7 figs.

  1. Stress response symptoms in adolescent and young adult children of parents diagnosed with cancer

    Huizinga, G.A.; Visser, A.; van der Graaf, W.T.; Hoekstra, H.J.; Klip, E.C.; Pras, E.; Hoekstra-Weebers, J.E.


    The aim of this study was to assess stress response symptoms in children of parents diagnosed with cancer 1-5 year prior to study entry. The impact of event scale was used to measure stress response symptoms in terms of intrusion and avoidance; the youth self-report assessed emotional and behavioura

  2. [Nursing diagnoses of the elderly at home].

    Figueiredo, Maria do Livramento Fortes; Luz, Maria Helena Barros Araújo; de Brito, Cleidiane Maria Sales; Sousa, Suéli Nolêto Silva; da Silva, Dâmaris Rebeca Soares


    The descriptive study, with quantitative approach, that has had as objective to do the characterization of ill elderly at home attended by the ESF teams of the Satellite's District in Teresina - PI and to collect Nursing Diagnoses and it respective interventions. This descriptive study was constituted by 50 seniors interviewed at home, the results showed that most of the women in age between of 60 and 79 years were ill at home for one or five years at least. There were eight Nursing Diagnoses (ND) prevalent, in which 98% of the seniors were identified with the ND - Inadequate Control of Therapeutic Regime, and in 72% the deambulation was prejudiced with mobility's limitation and, for all diagnoses were proposed nursing interventions objectifying the conquest of autonomy and independence of these seniors. PMID:18797782

  3. Events diary


    as Imperial College, the Royal Albert Hall, the Royal College of Art, the Natural History and Science Museums and the Royal Geographical Society. Under the heading `Shaping the future together' BA2000 will explore science, engineering and technology in their wider cultural context. Further information about this event on 6 - 12 September may be obtained from Sandra Koura, BA2000 Festival Manager, British Association for the Advancement of Science, 23 Savile Row, London W1X 2NB (tel: 0171 973 3075, e-mail: ). Details of the creating SPARKS events may be obtained from or from the website . Other events 3 - 7 July, Porto Alegre, Brazil VII Interamerican conference on physics education: The preparation of physicists and physics teachers in contemporary society. Info: or 27 August - 1 September, Barcelona, Spain GIREP conference: Physics teacher education beyond 2000. Info:

  4. Bordetella pertussis diagnosed by polymerase chain reaction

    Birkebaek, N H; Heron, I; Skjødt, K


    The object of this work was to test the polymerase chain reaction (PCR) for demonstration of Bordetella pertussis (BP) in nasopharyngeal secretions. The method was applied to patients with recently diagnosed pertussis, as verified by BP culture. In order to test the sensitivity and specificity of...

  5. Eating Disorder Diagnoses: Empirical Approaches to Classification

    Wonderlich, Stephen A.; Joiner, Thomas E., Jr.; Keel, Pamela K.; Williamson, Donald A.; Crosby, Ross D.


    Decisions about the classification of eating disorders have significant scientific and clinical implications. The eating disorder diagnoses in the Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV; American Psychiatric Association, 1994) reflect the collective wisdom of experts in the field but are frequently not supported in…

  6. Bilateral segmental neurofibromatosis diagnosed during pregnancy.

    Maldonado Cid, P; Sendagorta Cudós, E; Noguera Morel, L; Beato Merino, M J


    Bilateral segmental neurofibromatosis is a rare subtype of neurofibromatosis type 1 defined by lesions affecting a single segment of the body and crossing the midline, with no systemic involvement. We present a case diagnosed during pregnancy because of the characteristic increase in size of the lesions during this period. PMID:21635828

  7. Diagnosing and treating respiratory syncytial virus bronchiolitis.

    Napierkowski, Daria B


    Respiratory syncytial virus (RSV) is one of the major causes of respiratory tract illness in children and can lead to significant infection and death. This article discusses the incidence, clinical presentation, diagnosis, current treatment, and prevention options to successfully diagnose and treat infections caused by RSV. PMID:27552683

  8. Diagnosing risks in product-innovation projects

    Halman, J.I.M.; Keizer, J.A.


    A new method of diagnosing risks in product-innovation projects is introduced in the paper. The method is an improvement on existing risk methods used on product-innovation projects, such as potential problem analysis and failure mode and effects analysis. Technological, organizational and commercia

  9. Medicinalindustrien har brug for diagnoser som ADHD

    Fugl, Marie


    Det er ikke første gang, at medicinalindustriens evne til at finde nye markeder har medført nye eller bredere diagnoser. I det forrige årti så vi et parallelt forløb mellem et boom i antallet af depressionsdiagnoser og forbruget af lykkepiller. Interview med sociolog Thomas Brante. Udgivelsesdato...

  10. Diagnosing Febrile Illness in a Returned Traveler


    This podcast will assist health care providers in diagnosing febrile illness in patients returning from a tropical or developing country.  Created: 3/1/2012 by National Center for Enteric, Zoonotic, and Infectious Diseases (NCEZID).   Date Released: 3/1/2012.

  11. Two Siblings Diagnosed as Lafora Disease

    Yasemin Biçer Gömceli


    Full Text Available Lafora disease is a typical progressive myoclonic epilepsy that is characterized by autosomal recessive inheritance, myoclonic and occipital seizures, progressive dementia, ataxia, and dysarthria. Two siblings with myoclonic and generalized tonic clonic seizures, progressive dementia, ataxia and dysarthria, who were diagnosed as Lafora disease by sweat gland biopsy, are discussed.

  12. Reliability of clinical ICD-10 schizophrenia diagnoses

    Jakobsen, Klaus D; Frederiksen, Julie N; Hansen, Thomas;


    Concern has been expressed as to the reliability of clinical ICD-10 diagnosis of schizophrenia. This study was designed to assess the diagnostic reliability of the clinical ICD-10 diagnosis of schizophrenia in a random sample of Danish in- and outpatients with a history of psychosis. A sample of...... was seen between OPCRIT-derived ICD-10 and DSM-IV diagnoses (kappa=0.87). Thus, this study demonstrates high reliability of the clinical diagnosis of schizophrenia and even more so of the diagnosis of schizophrenia-spectrum disorder....... 100 subjects was assessed using the operational criteria OPCRIT checklist for psychotic and affective illness. The most recent principal and clinical ICD-10 diagnosis was compared with diagnoses generated by the OPCRIT instrument. Data documented very high sensitivity (93%) and positive predictive...

  13. Negative and positive childhood experiences across developmental periods in psychiatric patients with different diagnoses – an explorative study

    Schauer Margarete; Neuner Frank; Rockstroh Brigitte; Bichescu Dana; Saleptsi Evangelia; Studer Karl; Hoffmann Klaus; Elbert Thomas


    Abstract Background A high frequency of childhood abuse has often been reported in adult psychiatric patients. The present survey explores the relationship between psychiatric diagnoses and positive and negative life events during childhood and adulthood in psychiatric samples. Methods A total of 192 patients with diagnoses of alcohol-related disorders (n = 45), schizophrenic disorders (n = 52), affective disorders (n = 54), and personality disorders (n = 41) completed a 42-item self-rating s...

  14. An Appropriate Indicator for Diagnosing Gestational Diabetes

    Jui-Hung Sun; Lai-Chu See; Tsung-Hong Chiu; T’sang-T’ang Hsieh; Miau-Ju Huang


    Background: This study was intended to simplify the diagnostic procedure for gestationaldiabetes mellitus (GDM) through using a single plasma glucose level, after a100 g oral glucose tolerance test (OGTT), as the most appropriate indicatorfor diagnosing GDM in pregnant women with a positive 50 g, 1-hour oralglucose challenge test (GCT) in Northern Taiwan.Methods: A total of 973 native Taipei metropolitan pregnant women with a positiveGCT, who underwent a 100 g, 3-hour OGTT were retrospectivel...

  15. Best waveform score for diagnosing keratoconus

    Allan Luz; Bruno Machado Fontes; Bernardo Lopes; Isaac Ramos; Fernando Faria Correia; Paulo Schor; Renato Ambrósio Jr.


    PURPOSE: To test whether corneal hysteresis (CH) and corneal resistance factor (CRF) can discriminate between keratoconus and normal eyes and to evaluate whether the averages of two consecutive measurements perform differently from the one with the best waveform score (WS) for diagnosing keratoconus. METHODS: ORA measurements for one eye per individual were selected randomly from 53 normal patients and from 27 patients with keratoconus. Two groups were considered the average (CH-Avg, CRF-Avg)...

  16. Diagnosing dementia: do we get it right?

    Homer, A. C.; Honavar, M; Lantos, P L; Hastie, I R; Kellett, J M; Millard, P H


    To find out whether the diagnosis of dementia agreed with findings at necropsy a detailed assessment of 27 elderly patients (mean age 82 (range 70-94] presenting with dementia was conducted at a combined department of geriatric medicine and psychiatry for the elderly. On the basis of the results the cause of the dementia was diagnosed clinically. Neuropathological examinations were performed after death. The clinical diagnosis made during life was not supported by the findings at necropsy in ...

  17. Measuring Money Mismanagement Among Dually Diagnosed Clients

    Black, Ryan A.; Rounsaville, Bruce J.; Rosenheck, Robert A; Conrad, Kendon J.; Ball, Samuel A.; Rosen, Marc I.


    Clients dually diagnosed with psychiatric and substance abuse disorders may be adversely affected if they mismanage their Social Security or public support benefits. Assistance managing funds, including assignment of a representative payee, is available but there are no objective assessments of money mismanagement. In this study, a Structured Clinical Interview for Money Mismanagement was administered twice at one-week intervals to 46 clients receiving disability payments and was compared to ...

  18. Eosinophilic Pancreatitis Diagnosed With Endoscopic Ultrasound

    Kakodkar, Samir; Omar, Hina; Cabrera, Julio; Chi, Kenneth


    Eosinophilic pancreatitis (EP) is a rare clinical entity, and few cases have been reported. It usually presents on imaging as a pancreatic mass leading to common bile duct obstruction and jaundice. Since it can mimic a malignancy, eosinophilic pancreatitis is often diagnosed after “false positive” pancreatic resections. To our knowledge, we report the only known case of EP in which the diagnosis was made by fine needle aspiration and core biopsy of the pancreas during EUS, sparing the patient...

  19. Event Segmentation Ability Uniquely Predicts Event Memory

    Sargent, Jesse Q.; Zacks, Jeffrey M.; Hambrick, David Z.; Zacks, Rose T.; Kurby, Christopher A.; Bailey, Heather R.; Eisenberg, Michelle L.; Beck, Taylor M.


    Memory for everyday events plays a central role in tasks of daily living, autobiographical memory, and planning. Event memory depends in part on segmenting ongoing activity into meaningful units. This study examined the relationship between event segmentation and memory in a lifespan sample to answer the following question: Is the ability to segment activity into meaningful events a unique predictor of subsequent memory, or is the relationship between event perception and memory accounted for...

  20. Event Index - an LHCb Event Search System

    Ustyuzhanin, Andrey; Artemov, Alexey; Kazeev, Nikita; Redkin, Artem


    During LHC Run 1, the LHCb experiment recorded around $10^{11}$ collision events. This paper describes Event Index - an event search system. Its primary function is to quickly select subsets of events from a combination of conditions, such as the estimated decay channel or number of hits in a subdetector. Event Index is essentially Apache Lucene optimized for read-only indexes distributed over independent shards on independent nodes.

  1. Event Index - an LHCb Event Search System

    Ustyuzhanin, Andrey


    During LHC Run 1, the LHCb experiment recorded around 1011 collision events. This paper describes Event Index | an event search system. Its primary function is to quickly select subsets of events from a combination of conditions, such as the estimated decay channel or number of hits in a subdetector. Event Index is essentially Apache Lucene [1] optimized for read-only indexes distributed over independent shards on independent nodes.

  2. Talus avulsion fractures: are they accurately diagnosed?

    Robinson, Karen P; Davies, Mark B


    Dorsal talus avulsion fractures occurring along the supination line of the foot can cause pain and discomfort. Examination of the foot and ankle using the Ottawa ankle rules does not include examination of the talus, an injury here is easily missed causing concern to the patient. This is a retrospective study carried out in a major trauma centre to look at the assessment and diagnosis of all patients with a dorsal talus and navicular avulsion fractures over a one year period. Nineteen patients with an isolated dorsal talus avulsion fracture and five patients with an isolated dorsal navicular fracture were included. The correct diagnosis was made in 12 of patients with isolated dorsal talus avulsion fractures, 7 patients were given an incorrect diagnosis after misreading of the radiograph. Four patients with a dorsal navicular avulsion fracture were given the correct diagnosis. If not correctly diagnosed on presentation patients can be overly concerned that a 'fracture was missed' which can lead to confusion and anxiety. Therefore these injuries need to be recognised early, promptly diagnosed, treated symptomatically and reassurance given. We recommend the routine palpation of the talus in addition to the examination set out in the Ottawa Ankle Rules and the close inspection of plain radiographs to adequately diagnose an injury in this area. PMID:26190632

  3. An Appropriate Indicator for Diagnosing Gestational Diabetes

    Jui-Hung Sun


    Full Text Available Background: This study was intended to simplify the diagnostic procedure for gestationaldiabetes mellitus (GDM through using a single plasma glucose level, after a100 g oral glucose tolerance test (OGTT, as the most appropriate indicatorfor diagnosing GDM in pregnant women with a positive 50 g, 1-hour oralglucose challenge test (GCT in Northern Taiwan.Methods: A total of 973 native Taipei metropolitan pregnant women with a positiveGCT, who underwent a 100 g, 3-hour OGTT were retrospectively surveyed.GDM was defined according to the standards of National Diabetes DataGroup. Plasma glucose levels, obtained 1 hour following a GCT and at multipletiming following a 100 g oral glucose load, were used to plot receiveroperative characteristic curves to determine the most appropriate indicatorfor diagnosing GDM.Results: In the 973 pregnant women with a positive GCT, a 2-hour plasma glucoselevel above 165 mg/dl revealed a sensitivity and specificity of 91.2% and90.3%, respectively.Conclusions: To simplify the diagnostic procedure for GDM, we suggest that a 2-hourplasma glucose level above 165 mg/dl after a 100 g OGTT might be anappropriate indicator for diagnosing GDM in women with a positive GCT.

  4. Extracting Event Dynamics from Event-by-Event Analysis

    Fu, Jinghua; Liu, Lianshou


    The problem of eliminating the statistical fluctuations and extracting the event dynamics from event-by-event analysis is discussed. New moments $G_p$ (for continuous distribution), and $G_{q,p}$ (for anomalous distribution) are proposed, which are experimentally measurable and can eliminate the Poissonian type statistical fluctuations to recover the dynamical moments $C_p$ and $C_{q,p}$. In this way, the dynamical distribution of the event-averaged transverse momentum $\\bar{\\pt}$ can be extr...

  5. Acute Fetal Anemia Diagnosed by Middle Cerebral Artery Doppler Velocimetry in Stage V Twin–Twin Transfusion Syndrome

    Jennifer Salcedo


    Full Text Available In stage V twin–twin transfusion syndrome (TTTS, up to 50% of surviving twins die or experience permanent disabilities, likely due to acute intertwin hemorrhage resulting in sudden severe anemia of the survivor. Although fetal middle cerebral artery (MCA Doppler studies demonstrate strong correlation with fetal hemoglobin values, acute hemorrhagic events are more difficult to diagnose, and optimal timing of delivery of the survivor poses an obstetric dilemma. We report a case of newly diagnosed stage V TTTS at 28 weeks gestation, complicated by acute severe anemia diagnosed by significantly abnormal fetal MCA Doppler studies. The anemic twin was urgently delivered and is doing well without significant sequelae.

  6. Anal squamous carcinoma: a new AIDS-defining cancer? Case report and literature review

    Marcelo Corti


    Full Text Available Squamous anal cell carcinoma is a rare malignancy that represents the 1.5% to 2% of all the lower digestive tract cancers. However, an increased incidence of invasive anal carcinoma is observed in HIV-seropositive population since the widespread of highly active antiretroviral therapy. Human papillomavirus is strongly associated with the pathogenesis of anal cancer. Anal intercourse and a high number of sexual partners appear to be risk factors to develop anal cancer in both sexes. Anal pain, bleeding and a palpable lesion in the anal canal are the most common clinical features. Endo-anal ultrasound is the best diagnosis method to evaluate the tumor size, the tumor extension and the infiltration of the sphincter muscle complex. Chemoradiotherapy plus antiretroviral therapy are the recommended treatments for all stages of localized squamous cell carcinoma of the anal canal in HIV-seropositive patients because of its high rate of cure. Here we present an HIV patient who developed a carcinoma of the anal canal after a long time of HIV infection under highly active antiretroviral therapy with a good virological and immunological response.

  7. Emergence of Azoles Resistance Candida species in Iranian AIDS defined patients with oropharyngeal candidiasis

    Farzad Katiraee


    Conclusion: Based on the findings, it can be concluded that screening of resistant Candida isolates by disk diffusion or broth dilution method is essential for the surveillance and prevention of antifungal resistance in patient management. Although nystatin is widely used in clinical practice for HIV patients in Iran, no evidence of enhanced resistance against this agent was found on the other hand, resistance to azole antifungals, particularly fluconazole, increased. Considering the lack of resistance to caspofungin, administration of this agent is suggested for the treatment of OPC in AIDS patients.

  8. Best waveform score for diagnosing keratoconus

    Allan Luz


    Full Text Available PURPOSE: To test whether corneal hysteresis (CH and corneal resistance factor (CRF can discriminate between keratoconus and normal eyes and to evaluate whether the averages of two consecutive measurements perform differently from the one with the best waveform score (WS for diagnosing keratoconus. METHODS: ORA measurements for one eye per individual were selected randomly from 53 normal patients and from 27 patients with keratoconus. Two groups were considered the average (CH-Avg, CRF-Avg and best waveform score (CH-WS, CRF-WS groups. The Mann-Whitney U-test was used to evaluate whether the variables had similar distributions in the Normal and Keratoconus groups. Receiver operating characteristics (ROC curves were calculated for each parameter to assess the efficacy for diagnosing keratoconus and the same obtained for each variable were compared pairwise using the Hanley-McNeil test. RESULTS: The CH-Avg, CRF-Avg, CH-WS and CRF-WS differed significantly between the normal and keratoconus groups (p<0.001. The areas under the ROC curve (AUROC for CH-Avg, CRF-Avg, CH-WS, and CRF-WS were 0.824, 0.873, 0.891, and 0.931, respectively. CH-WS and CRF-WS had significantly better AUROCs than CH-Avg and CRF-Avg, respectively (p=0.001 and 0.002. CONCLUSION: The analysis of the biomechanical properties of the cornea through the ORA method has proved to be an important aid in the diagnosis of keratoconus, regardless of the method used. The best waveform score (WS measurements were superior to the average of consecutive ORA measurements for diagnosing keratoconus.

  9. Psychotherapy Techniques for Patients Diagnosed with Schizophrenia.

    Lotterman, Andrew C


    The paper describes how standard psychotherapy techniques need to be modified to suit the specialized needs of patients diagnosed with schizophrenia. Patients with psychosis often have lost their ability to use words to describe their inner states. As a result, traditional forms of psychotherapy which depend so crucially on the use of language are compromised. The goal of treatment at the start is to help the patient recover his ability to use language to describe his inner life. Eventually, this enables the patient to make use of more traditional forms of psychodynamic treatment. PMID:27052606

  10. Neuroimaging differential diagnoses to abusive head trauma

    Girard, Nadine [AP-HM Timone 2, Department of Neuroradiology, Marseille cedex 05 (France); Aix Marseille University, UMR CNRS 7339, Marseille (France); Brunel, Herve; Dory-Lautrec, Philippe [AP-HM Timone 2, Department of Neuroradiology, Marseille cedex 05 (France); Chabrol, Brigitte [AP-HM Timone, Department of Pediatric Neurology, Marseille (France)


    Trauma is the most common cause of death in childhood, and abusive head trauma is the most common cause of traumatic death and morbidity in infants younger than 1 year. The main differential diagnosis of abusive head trauma is accidental traumatic brain injury, which is usually witnessed. This paper also discusses more uncommon diagnoses such as congenital and acquired disorders of hemostasis, cerebral arteriovenous malformations and metabolic diseases, all of which are extremely rare. Diagnostic imaging including CT and MRI is very important for the distinction of non-accidental from accidental traumatic injury. (orig.)

  11. Accuracy of Ultrasonography in Diagnosing Acute Appendicitis

    Parisa Javidi Parsijani; Nima Pourhabibi Zarandi; Shahram Paydar; Hamidreza Abbasi; Shahram Bolandparvaz


    Objectives: To evaluate the accuracy of sonography in diagnosing acute appendicitis in patients with Alvarado score 4–7.Methods: This is a retrospective cross-sectional study being performed in Namazee hospital affiliated with Shiraz University of Medical sciences during a one year period from 9/2007 to 9/2008. We evaluated all patients with Alvarado score 4-7 and divided them in two groups: those with Ultrasound study prior to surgery and those without any imaging modalities for diagnosis of...

  12. Diagnosing risks in product-innovation projects

    Halman, JIM Joop; Keizer, JA Jimme


    A new method of diagnosing risks in product-innovation projects is introduced in the paper. The method is an improvement on existing risk methods used on product-innovation projects, such as potential problem analysis and failure mode and effects analysis. Technological, organizational and commercial risks are identified and assessed on an individual basis. These risks are mapped in a risk topography which is used as an input for the drawing up of a risk-management plan. The method has been d...

  13. Benign intracranial hypertension diagnosed with bilateral papilloedema

    K. C. Phillips


    Full Text Available This article presents a case of benign intracranial hypertension (BIH diagnosed from the presence of papilloedema. This potentially sight-threatening condition particularly affects younger obese females and can be idiopathic, caused by adverse reaction to certain prescription medications or by systemic disease. Prompt treatment is essentialto avoid optic atrophy and low energy diet and exercise forms part of long-term treatment to avoid relapse. Optometrists can play a critical primary health care role in the detection of papilloedema and referring appropriately.

  14. Computer Assisted Diagnoses for Red Eye (CADRE)

    Muhammad Zubair Asghar; Abdur Rashid Khan; Muhammad Junaid Asghar


    This paper introduces an expert System (ES) named as “CADRE-Computer Assisted Diagnoses for Red Eye. Mostly the remote areas of the population are deprived of the facilities of having experts in eye disease. So it is the need of the day to store the expertise of Eye specialists in computers through using ES technology. This ES is a rule-based Expert System that assists in red-eye diagnosis and treatment. The knowledge acquired from literature review and human experts of the specific domain wa...

  15. Neuroimaging differential diagnoses to abusive head trauma

    Trauma is the most common cause of death in childhood, and abusive head trauma is the most common cause of traumatic death and morbidity in infants younger than 1 year. The main differential diagnosis of abusive head trauma is accidental traumatic brain injury, which is usually witnessed. This paper also discusses more uncommon diagnoses such as congenital and acquired disorders of hemostasis, cerebral arteriovenous malformations and metabolic diseases, all of which are extremely rare. Diagnostic imaging including CT and MRI is very important for the distinction of non-accidental from accidental traumatic injury. (orig.)

  16. Dig-event: let's socialize around events

    Zhao, Zhenzhen; Liu, Ji; Crespi, Noel


    International audience Traditional social networks socialize around the contents that have uploaded to these sites and discover interesting contents uploaded by others. In this demo we aim to explore the idea of activity-oriented social networks. We design a novel social networking site called Dig-Event (Do-it-together Event), where people are able to share events through calendar, while discover interesting events shared by others. Our demo has been inspired by previous research on calend...

  17. Sulfasalazine and temozolomide with radiation therapy for newly diagnosed glioblastoma

    Satoru Takeuchi


    Full Text Available Background: A recent phase 1/2 clinical trial argued for caution for the use of sulfasalazine in progressive glioblastoma (GBM. However, the study enrolled patients with recurrent or progressive high-grade glioma indicating that patients recruited probably had severe disease. Thus, the study may not accurately reflect the effectiveness of sulfasalazine for GBM and we hypothesized that earlier sulfasalazine administration may lead to anticancer effects. Aim: The aim of this study was to investigate whether sulfasalazine can improve the outcomes of patients with newly diagnosed GBM. Subjects and Methods: A total of 12 patients were treated with temozolomide and sulfasalazine with radiation therapy after surgery. Twelve patients with primary GBM treated with temozolomide and radiation therapy formed the control group. Progression-free survival (PFS, overall survival (OS and seizure-free survival (SFS curves were obtained using the Kaplan-Meier method. The survival curves were compared using the log-rank test. Results: The median OS, PFS and SFS did not differ between the groups. Grade 3 or 4 adverse events occurred over the duration of the study in nine (75% patients. The median SFS was 12 months in nine patients who received sulfasalazine administration for more than 21 days, which was strongly but not significantly longer than the 3 months observed in the control group (P = 0.078. Conclusions: Sulfasalazine treatment with temozolomide plus radiotherapy for newly diagnosed primary GBM is associated with a high rate of discontinuation due to hematologic toxic effects. This treatment may have no effect on OS or PFS, although it may improve seizure control if an adequate dose can be administered.

  18. Diagnosing sepsis - The role of laboratory medicine.

    Fan, Shu-Ling; Miller, Nancy S; Lee, John; Remick, Daniel G


    Sepsis is the host response to microbial pathogens resulting in significant morbidity and mortality. An accurate and timely diagnosis of sepsis allows prompt and appropriate treatment. This review discusses laboratory testing for sepsis because differentiating systemic inflammation from infection is challenging. Procalcitonin (PCT) is currently an FDA approved test to aid in the diagnosis of sepsis but with questionable efficacy. However, studies support the use of PCT for antibiotic de-escalation. Serial lactate measurements have been recommended for monitoring treatment efficacy as part of sepsis bundles. The 2016 sepsis consensus definitions include lactate concentrations >2mmol/L (>18mg/dL) as part of the definition of septic shock. Also included in the 2016 definitions are measuring bilirubin and creatinine to determine progression of organ failure indicating worse prognosis. Hematologic parameters, including a simple white blood cell count and differential, are frequently part of the initial sepsis diagnostic protocols. Several new biomarkers have been proposed to diagnose sepsis or to predict mortality, but they currently lack sufficient sensitivity and specificity to be considered as stand-alone testing. If sepsis is suspected, new technologies and microbiologic assays allow rapid and specific identification of pathogens. In 2016 there is no single laboratory test that accurately diagnoses sepsis. PMID:27387712

  19. Problems with diagnosing Conversion Disorder in response to variable and unusual symptoms

    Barnum R


    Full Text Available Richard BarnumPrivate practice, Child and adolescent psychiatry, MA, USAAbstract: Conversion Disorder (CD is a diagnosis offered to explain signs and symptoms that do not correspond to recognized medical conditions. Pediatric patients with variable, vague, and multisystem complaints are at increased risk for being diagnosed with CD. Little is known about the impact of such a diagnosis. In making such diagnoses, it is likely that pediatric providers hope to encourage patients to access mental health care, but no basis exists to show that these diagnoses result in such access in any useful way. This article presents the case of a child with Ehlers-Danlos Syndrome, who had been previously (incorrectly diagnosed with CD and referred for mental health care. It offers commentary based on interviews with other pediatric patients with similar experiences – conducted in collaboration with the Ehlers-Danlos National Foundation. These cases indicate that CD diagnoses can seriously undermine patients’ trust in doctors, and can create such defensiveness that it may interfere with (especially patients’ abilities to engage with mental health services. Such interference is an important problem, if the diagnosis is accurate. But, in the (more likely event that it is not accurate, this defensiveness can interfere with both important mental health care and further ongoing necessary medical care.Keywords: somatoform disorders, dysautonomias, pain, collagen diseases, mitochondrial diseases, complex regional pain syndromes

  20. Public events, private events: the visible structure of media events

    Lígia Campos de Cerqueira lana


    Full Text Available Facts apparently irrelevant about the private life of celebrities compose the agenda of contemporary media. Despite its weak public interest, these events have major repercussions in collective life, repositioning the rigid opposition between public and private events. When events gain publicity in the media, they become relevant through a work to make visible specific aspects of its constitution. The targeting of certain issues is related to causal network of meanings. Public and private events, when subjected to the regime of media visibility, have a similar structure, conditioned to its configuration and activity of individuals involved.

  1. Discharge diagnoses versus medical record review in the identification of community-acquired sepsis

    Henry E. Wang; Addis, Dylan R; Donnelly, John P.; Shapiro, Nathan I.; Griffin, Russell L.; Safford, Monika M.; Baddley, John W.


    Introduction We evaluated the accuracy of hospital discharge diagnoses in the identification of community-acquired sepsis and severe sepsis. Methods We reviewed 379 serious infection hospitalizations from 2003 to 2012 from the national population-based reasons for geographic and racial differences in stroke (REGARDS) cohort. Through manual review of medical records, we defined criterion-standard community-acquired sepsis events as the presence of a serious infection on hospital presentation w...

  2. How Do Health Care Providers Diagnose Cushing's Syndrome?

    ... and Publications How do health care providers diagnose Cushing’s syndrome? Skip sharing on social media links Share this: Page Content Diagnosing Cushing’s syndrome can be complex and difficult. This syndrome is ...

  3. How Do Health Care Providers Diagnose Turner Syndrome?

    ... and Publications How do health care providers diagnose Turner syndrome? Skip sharing on social media links Share this: ... the X chromosomes is partially or completely missing. Turner syndrome also can be diagnosed during pregnancy by testing ...

  4. How Do Health Care Providers Diagnose Spina Bifida?

    ... and Publications How do health care providers diagnose spina bifida? Skip sharing on social media links Share this: Page Content Doctors diagnose spina bifida before or after the infant is born. Spina ...

  5. Time trend in diagnosing dementia in secondary care

    Phung, Thien Kieu Thi; Waltoft, Berit Lindum; Kessing, Lars Vedel;


    To study the trend of diagnosing dementia in the secondary health care sector over time, we conducted a nationwide longitudinal study of the incidence and prevalence of registered dementia diagnoses in the Danish national hospital registers.......To study the trend of diagnosing dementia in the secondary health care sector over time, we conducted a nationwide longitudinal study of the incidence and prevalence of registered dementia diagnoses in the Danish national hospital registers....

  6. How Is High Blood Cholesterol Diagnosed?

    ... with other women on Facebook . The Heart Truth campaign offers a variety of public health resources to help educate women and health professionals about women’s heart disease. Learn more about key campaign events, activities, and resources at . ...

  7. Nichtinvasive Diagnose der Leberfibrose bei chronischen Hepatopathien

    Stauber R


    Full Text Available Die Beurteilung der Leberfibrose ist bedeutsam für die Prognose, Therapieindikation und Verlaufskontrolle bei chronisch-progredienten Hepatopathien. Referenztest (Goldstandard ist derzeit die histologische Beurteilung von Leberbiopsaten. Da die Leberbiopsie jedoch ein gewisses Risiko birgt, sind zuverlässige nicht-invasive Fibrosetests sehr wünschenswert. Der vorliegende Artikel soll eine Übersicht über die wichtigsten nicht-invasiven Fibrosetests und deren diagnostische Aussagekraft hinsichtlich signifikanter Fibrose bzw. Zirrhose bei verschiedenen Lebererkrankungen bieten. Die meisten Studien wurden bei chronischer Hepatitis C durchgeführt, aber auch bei nicht-alkoholischer Fettlebererkrankung gewinnt diese Fragestellung an Bedeutung. Anhand der vorliegenden Daten ist die Aussagekraft einfacher (auf Routinelaborwerten basierender Fibrosetests hinsichtlich signifikanter Fibrose offenbar ähnlich wie diejenige der komplexeren Biomarker. Die Ultraschall-Elastographie (Fibroscan ™ erscheint jedoch als überlegene Methode zur Diagnose von Zirrhose bzw. eventuell auch von klinisch-signifikanter portaler Hypertonie.

  8. Excess mortality in patients diagnosed with hypothyroidism

    Thvilum, Marianne; Brandt, Frans; Pedersen, Dorthe Almind;


    Background: Although hypothyroidism is associated with increased morbidity, an association with increased mortality is still debated. Our objective was to investigate, at a nationwide level, whether a diagnosis of hypothyroidism influences mortality. Methods: In an observational cohort study from...... January 1, 1978 until December 31, 2008 using record-linkage data from nationwide Danish health registers, 3587 singletons and 682 twins diagnosed with hypothyroidism were identified. Hypothyroid individuals were matched 1:4 with nonhypothyroid controls with respect to age and gender and followed over a...... mean period of 5.6 years (range 0-30 years). The hazard ratio (HR) for mortality was calculated using Cox regression analyses. Comorbidity was evaluated using the Charlson score (CS). Results: In singletons with hypothyroidism, the mortality risk was increased (HR 1.52; 95% confidence interval [CI]: 1...

  9. Ultrasonic findings in diagnosing renal colic

    Lee, Myung Jin; Kim, Mee Hyun; Lee, Young Joong; Yoon, Jong Sup [Hallym University College of Medicine, Chuncheon (Korea, Republic of)


    To determine diagnostic values of ultrasonography in evaluation of renal colic, ultrasonographic study of 35 patients in whom renal colic was clinically suspected was undertaken. The sonographic criterion for a positive finding consisted of visualization of urinary tract calculus with posterior acoustic shadowing, with or without ureterectasis. Renal colic was correctly diagnosed by ultrasonography in 28 patients of 33 patients with proven ureteric stone, for an accuracy of 85%. Of the 33 patients with proven ureteric stone, there were 3 cases with ureteropelvic junction stone, 4 cases with abdominal ureter stone, 4 cases with iliac ureter stone, 4 cases with pelvic ureter stone and 18 cases with ureterovesical junction stone. The results show that ultrasonography in an effective initial screening test when renal colic is clinically suspected.

  10. No real-time prognoses without diagnoses

    ECN is developing a 'problem oriented user guide' for a PC-based computer programme for real-time prognoses. This programme, infoREM, calculates the potential consequences of a nuclear accident from reported radioactive releases to the atmosphere and weather forecasts. This user guide will help the staff of the local and national co-ordination centres to use InfoREM to perform the necessary calculations with the data available during a nuclear accident. In particular, the guide will help them to critically diagnose the results calculated before using these when implementing monitoring plans and countermeasures. This paper discusses an instruction set for performing 'simple prognoses' as an example for the methodology of the user guide. This set has been developed by ECN for the monitoring and decontamination teams of the fire brigades. In addition, the structure of infoREM is discussed. (orig.)

  11. Postnatal Treatment in Antenatally Diagnosed Meconium Peritonitis.

    Ionescu, S; Andrei, B; Oancea, M; Licsandru, E; Ivanov, M; Marcu, V; Popa-Stanila, R; Mocanu, M


    Meconium peritonitis is a rare prenatal disease with an increased rate of morbidity and mortality in the neonatal period. Distinctive features revealed by prenatal and postnatal ultrasoundmay be present: abdominal calcifications, ascites, polyhydramnios, meconium pseudocyst, echogenic mass and dilated bowel or intestinal obstruction. Establishing clear postnatal treatment and prognosis is difficult because of the heterogeneity of the results obtained by ultrasound. The aim of the study is to determine how prenatal diagnosis of meconium peritonitis is associated with perinatal management and further evolution. Clinical results are different depending on the presence of antenatal diagnosis of meconium peritonitis and its form, which can be mild or severe. Surgical treatment and management of meconium peritonitis depend on the clinical presentation of the newborn. Meconium peritonitis diagnosed prenatally differs from that of the newborn, not only concerning the mortality rates but also through reduced morbidity and overall better prognosis. PMID:26713828

  12. Alternative diagnoses at paediatric appendicitis MRI

    As the utilization of MRI in the assessment for paediatric appendicitis increases in clinical practice, it is important to recognize alternative diagnoses as the cause of abdominal pain. The purpose of this review is to share our institution's experience using MRI in the evaluation of 510 paediatric patients presenting with suspected appendicitis over a 30 month interval (July 2011 to December 2013). An alternative diagnosis was documented in 98/510 (19.2%) patients; adnexal pathology (6.3%, n = 32), enteritis–colitis (6.3%, n = 32), and mesenteric adenitis (2.2%, n = 11) comprised the majority of cases. These common entities and other less frequent illustrative cases obtained during our overall institutional experience with MRI for suspected appendicitis are reviewed

  13. Editorial: Testing and Diagnosing Social Science Literacy

    Birgit Weber


    Full Text Available A year ago the Journal of Social Science Education 4/2010 invites to debate the foundation of social science literacy. What are the competences, and ‘what are’ the contents, and individual needs to understand the relations, systems and orders of society, economy and politics? What helps to make autonomously found decisions and responsible judgements in individual and social life? What kind of abilities are needed for autonomous action within ones own life in order to participate within the given frames of society, economy and politics, in shaping them or in creating new rules. Search and discussion of the relevant concepts and competences in the domain of social science education are going on. Nevertheless the research on testing and diagnosing social science literacy is carried as well – despite the absence of a consensus on content.

  14. A case of thoracogastropagus diagnosed before delivery.

    Hayashi, M; Tomobe, K; Yaoi, Y


    The subject was a 29-year-old pregnant woman whose fetuses were a conjoined twin. We diagnosed the fetuses as a conjoined twin by ultrasonography at the 12th week of gestation. The patient and her family wanted living infants and hoped that they were separated surgically. We consulted with the doctors of pediatric surgery and cardiovascular surgery departments. At the 18th week of gestation, the fetuses died in utero and they were delivered transvaginally by labor induction. Both infants were female with 430 g in total body weight and both of them were 21 cm in length. Pathological findings were thoracogastro-pagus with a single heart, a single pair of liver and a single small intestine. PMID:9704294

  15. Optical coherence tomography for diagnosing periodontal disease

    Colston, Bill W., Jr.; Everett, Matthew J.; Da Silva, Luiz B.; Otis, Linda L.; Nathel, Howard


    We have, in this preliminary study, investigated the use of optical coherence tomography for diagnosis of periodontal disease. We took in vitro OCT images of the dental and periodontal tissues from a young pig and compared them to histological sections. These images distinguish tooth and soft tissue relationships that are important in diagnosing and assessing periodontal disease. We have imaged the attachment of gingiva to the tooth surface and located the cemento-enamel junction. This junction is an important reference point for defining attachment level in the diagnosis of periodontal disease. the boundary between enamel and dentin is also visible for most of the length of the anatomical crown, allowing quantitation of enamel thickness and character.

  16. Automated diagnostic kiosk for diagnosing diseases

    Regan, John Frederick; Birch, James Michael


    An automated and autonomous diagnostic apparatus that is capable of dispensing collection vials and collections kits to users interesting in collecting a biological sample and submitting their collected sample contained within a collection vial into the apparatus for automated diagnostic services. The user communicates with the apparatus through a touch-screen monitor. A user is able to enter personnel information into the apparatus including medical history, insurance information, co-payment, and answer a series of questions regarding their illness, which is used to determine the assay most likely to yield a positive result. Remotely-located physicians can communicate with users of the apparatus using video tele-medicine and request specific assays to be performed. The apparatus archives submitted samples for additional testing. Users may receive their assay results electronically. Users may allow the uploading of their diagnoses into a central databank for disease surveillance purposes.

  17. Juvenile myoclonic epilepsy: Under-diagnosed syndrome

    Božić Ksenija


    Full Text Available Introduction. Juvenile myoclonic epilepsy is an idiopathic, hereditary form of epilepsy. Although juvenile myoclonic epilepsy is a well defined clinical syndrome, attempts at diagnosing it commonly fail. Etiopathogenesis. The exact cause of juvenile myoclonic epilepsy remains unknown. Clinical, morphological and metabolic data suggest a preferential role for frontal regions in this syndrome. Several major genes for juvenile myoclonic epilepsy have been identified, but these genes account for only a small proportions of juvenile myoclonic epilepsy cases, suggesting multifactorial or complex inheritance in most. Clinical Manifestations. Juvenile myoclonic epilepsy is characterized by the triad of myoclonic jerks on awakening (all patients, generalized tonic-clonic seizures (>90% of patients and typical absences (about one third of patients. Seizures have an age-related onset, circadian distribution and are frequently precipitated by sleep deprivation, fatigue and alcohol intake. Intelligence is normal. Diagnosis. Juvenile myoclonic epilepsy diagnosis is based upon clinical criteria and typical electroencephalographic findings (generalized pattern of spikes and/or polyspikes and waves. All other tests are normal. Treatment and Prognosis. Both medical treatment and counselling are important in the management of juvenile myoclonic epilepsy. Mono-therapy with valproate is the preferred treatment. Some of the newer antiepileptic drugs have been suggested as possible alternatives. Juvenile myoclonic epilepsy has a good prognosis. Lifelong treatment is usually considered necessary in vast majority of patients due to the increased risk of relapse if treatment is discontinued. Conclusion. Juvenile myoclonic epilepsy is a common, although under-diagnosed epileptic syndrome. The clinician should study the occurrence of myoclonic jerks and should consider atypical presentations.

  18. Diagnosing pulmonary embolism using artificial neural networks

    Pulmonary Embolism (PE), an obstruction of pulmonary blood flow to the distal lung is a life-threatening condition causing chest pain and difficulty of breathing. Hence, prompt diagnosis is necessary so to render medical attention immediately. The standard way of diagnosing PE is through Lung Scintigraphy analyzed by Nuclear Medicine physicians. An expert system using artificial neural network (ANN) is created to diagnose PE with its probability based on Prospective Investigation of Pulmonary Embolism Diagnosis (PIOPED). A set of patients who underwent lung scan due to PE formed the training group while another set of patients formed the test group. None of the training group scans was included in the test group. The training group was trained by ANN using the back propagation method and Delta Rule while the test group was used to measure the performance of the expert system. All scans were examined independently by one expert nuclear medicine physician based on PIOPED criteria. The expert system is a standalone application with user-friendly interface. It shows all the 8 standard projections of lung scan. White spots and hot spots are detected and effectively reduced in the images to warrant more accurate diagnosis. Spaces around the lung images are also removed ensuring proper alignment of the ventilation and perfusion images to the template. Likewise, the system is able to quantify the mismatched between the ventilation and perfusion images. Based on the evaluation of the test group, the system is able to match the diagnosis of the expert physician by 80 %. The expert system can be used as a temporary substitute when there are no immediate help from expert physicians. It can also be used as a teaching tool by resident doctors training in radiology or nuclear medicine and is not meant to replace the expert physicians diagnosis. (authors)

  19. Causes and outcome of prenatally diagnosed hydronephrosis

    Ahmadzadeh Ali


    Full Text Available Hydronephrosis is the most common abnormal finding in the urinary tract on prenatal screening with ultrasonography (U/S. Hydronephrosis may be obstructive or non-obstructive; obstructive lesions are more harmful to the developing kidneys. The aim of the study was to evaluate the causes of renal pelvic dilatation and the outcome of postnatal treatment in infants with hydronephrosis diagnosed prenatally with U/S. We prospectively studied 67 (60 males newborns with hydronephrosis diagnosed prenatally and confirmed postnatally with U/S from Sept. 2005 to Oct. 2007. The patients were allocated to three groups based on the mea-surement of the anteroposterior renal pelvic diameter (APRPD in transverse plane: mild (6-9.9 mm, moderate (10-14.9 mm and severe (> 15 mm hydronephrosis. Voiding cystourethrography (VCUG was obtained in all of the patients to rule out vesicoureteral reflux (VUR. In cases with negative VUR, Diethylenetriamine-pentaacetic acid (DTPA scan with diuretic renography was performed to detect ureteropelvic joint obstruction (UPJO. Twenty two cases (32.8% had mild, 20 (29.9% had moderate, and 25 (37.3% had severe hydronephrosis. The causes of hydroneph-rosis were VUR (40.2%, UPJO (32.8%, posterior urethral valves (PUVs (13.4 %, and transient hydronephrosis (13.4 %. The lesion was obstructive in 37 (55.2% infants. Totally, 33 (49.2% patients with hydronephrosis (9 mild, 9 moderate, and 15 severe subsequently developed com-plications such as UTI and renal insufficiency, or required surgery. Associated abnormalities were observed in 15 (22.4% patients. We conclude that every newborn with any degree of hydro-nephrosis should be assessed postnatally for specific diagnosis and treatment.

  20. Causes and outcome of prenatally diagnosed hydronephrosis

    Hydronephrosis is the most common abnormal finding in the urinary tract on prenatal screening with ultrasonography (U/S). Hydronephrosis may be obstructive or nonobstructive; obstructive lesions are more harmful to the developing kidneys. The aim of the study was to evaluate the causes of renal pelvic dilatation and the outcome of postnatal treatment in infants with hydronephrosis diagnosed prenatally with U/S. We prospectively studied 67 (60 males) newborns with hydronephrosis diagnosed prenatally and confirmed postnatally with U/S from Sept. 2005 to Oct. 2007. The patients were allocated to three groups based on the mea-surement of the anteroposterior renal pelvic diameter (APRPD) in transverse plane: mild (6-9.9 mm), moderate (10-14.9 mm) and severe (> 15 mm) hydronephrosis. Voiding cystourethrography (VCUG) was obtained in all of the patients to rule out vesicoureteral reflux (VUR). In cases with negative VUR, Diethylenetriamine-pentaacetic acid (DTPA) scan with diuretic renography was performed to detect ureteropelvic joint obstruction (UPJO). Twenty two cases (32.8%) had mild, 20 (29.9%) had moderate, and 25 (37.3%) had severe hydronephrosis. The causes of hydronephrosis were VUR (40.2%), UPJO (32.8%), posterior urethral valves (PUVs) (13.4 %), and transient hydronephrosis (13.4 %). The lesion was obstructive in 37 (55.2%) infants. Totally, 33 (49.2%) patients with hydronephrosis (9 mild, 9 moderate, and 15 severe) subsequently developed complications such as UTI and renal insufficiency, or required surgery. Associated abnormalities were observed in 15 (22.4%) patients. We conclude that every newborn with any degree of hydronephrosis should be assessed postnatally for specific diagnosis and treatment. (author)

  1. Diagnosing chronic thromboembolic pulmonary hypertension: current perspectives

    Hadinnapola C


    Full Text Available Charaka Hadinnapola, Deepa Gopalan, David P Jenkins Papworth Hospital National Health Service Foundation Trust, Papworth Everard, Cambridge, United Kingdom Abstract: Chronic thromboembolic pulmonary hypertension is a rare and relatively poorly understood disease. It remains underdiagnosed and is often not recognized in primary and secondary care, as its symptoms are nonspecific and there are few clinical signs until late in the disease process. However, pulmonary endarterectomy (PEA offers a potential cure for patients with this type of pulmonary hypertension; therefore, it is important that they are identified and diagnosed in a timely manner. PEA is associated with a 2.2%–5% risk of significant morbidity and mortality, even in experienced PEA centers. Therefore, once chronic thromboembolic pulmonary hypertension is diagnosed, further assessment of operability and patient selection is crucial. Assessment of operability involves determining the distribution and burden of chronic thromboembolic disease, assessing pulmonary hemodynamics, and assessing the functional impairment of the patient. Ventilation perfusion scintigraphy is of value in screening for the presence of chronic thromboembolic disease. However, computer tomography pulmonary angiography and magnetic resonance pulmonary angiography are now increasingly used to image the vascular occlusions directly. This allows assessment of the surgically accessible disease burden. Some centers still advocate conventional selective pulmonary angiography for the latter. Right-heart catheterization remains the gold standard for assessing pulmonary hemodynamics. Higher pulmonary vascular resistances are associated with poorer outcomes as well as increased risks at the time of surgery. This is in part because of the presence of more distal chronic thromboembolic material and distal pulmonary artery remodeling. However, in experienced centers, these patients are being operated on safely and with good

  2. Hyperlocal event extraction of future events

    Arrskog, Tobias; Exner, Peter; Jonsson, Håkan; Norlander, Peter; Nugues, Pierre


    From metropolitan areas to tiny villages, there is a wide variety of organizers of cultural, business, entertainment, and social events. These organizers publish such information to an equally wide variety of sources. Every source of published events uses its own document structure and provides dierent sets of information. This raises signicant customization issues. This paper explores the possibilities of extracting future events from a wide range of web sources, to determine if the document...

  3. Cost-effectiveness of statins for primary prevention in newly diagnosed type 2 diabetes patients in the Netherlands

    de Vries, Dianna; Denig, P.; Visser, Sipke; Hak, E.; Postma, M.J.


    Objectives: Statins reduce the risk of cardiovascular events in patients with diabetes. The aim of this study is to determine whether statin treatment for primary prevention in newly diagnosed type 2 diabetes is cost-effective taking non-adherence, baseline risk, and age into account. Methods: A cos

  4. Improving the Specificity of EEG for Diagnosing Alzheimer's Disease

    François-B. Vialatte


    Full Text Available Objective. EEG has great potential as a cost-effective screening tool for Alzheimer's disease (AD. However, the specificity of EEG is not yet sufficient to be used in clinical practice. In an earlier study, we presented preliminary results suggesting improved specificity of EEG to early stages of Alzheimer's disease. The key to this improvement is a new method for extracting sparse oscillatory events from EEG signals in the time-frequency domain. Here we provide a more detailed analysis, demonstrating improved EEG specificity for clinical screening of MCI (mild cognitive impairment patients. Methods. EEG data was recorded of MCI patients and age-matched control subjects, in rest condition with eyes closed. EEG frequency bands of interest were θ (3.5–7.5 Hz, α1 (7.5–9.5 Hz, α2 (9.5–12.5 Hz, and β (12.5–25 Hz. The EEG signals were transformed in the time-frequency domain using complex Morlet wavelets; the resulting time-frequency maps are represented by sparse bump models. Results. Enhanced EEG power in the θ range is more easily detected through sparse bump modeling; this phenomenon explains the improved EEG specificity obtained in our previous studies. Conclusions. Sparse bump modeling yields informative features in EEG signal. These features increase the specificity of EEG for diagnosing AD.

  5. Keterlibatan Event Stakeholders pada Keberhasilan Event PR

    Lidya Wati Evelina


    The objective of this article is to determine how event organizers collaborate with stakeholders including the media, particular community, sponsors, participants, venue providers, accommodation providers, carteres, legal and finance personnel, production, local trade, transportation providers, government and associations for implementation Public Relations event. This paper discusses about the things that must be done for the cooperation and the benefits of cooperation undertaken. The method...

  6. Practices Surrounding Event Photos

    Vyas, Dhaval; Nijholt, Anton; Veer, van der, P.T.; Kotzé, P; Marsden, G.; Lindgaard, G.; Wesson, J.; Winckler, M.


    Sharing photos through mobile devices has a great potential for creating shared experiences of social events between co-located as well as remote participants. In order to design novel event sharing tools, we need to develop indepth understanding of current practices surrounding these so called ‘event photos’- photos about and taken during different social events such as weddings picnics, and music concert visits among others. We studied people’s practices related to event photos through in-d...

  7. Vitamin C nutriture in newly diagnosed diabetes.

    Shim, Jae Eun; Paik, Hee Young; Shin, Chan Soo; Park, Kyong Soo; Lee, Hong Kyu


    This study was performed to investigate the relationship between serum L-ascorbic acid, vitamin C intake, and diabetes in a nested case-control study. A cross-sectional survey of diet and health was conducted in 2,048 adults with an age of 30 y or older in Yonchon County, Korea. An oral glucose tolerance test was administered to all participants. One hundred cases of newly diagnosed diabetes were identified. Two healthy controls for each case matched with age, gender, drinking status, and smoking status were selected among the survey participants. L-Ascorbic acid levels were analyzed in fasting serum samples and one 24-h dietary recall was performed. Dietary vitamin C intake of persons with diabetes was 50.1±47.6 mg/d and that of controls was 55.1±41.1 mg/d. People with diabetes (22.3±16.8 µmol/L) have lower serum ascorbic acid levels than their controls (26.3±17.0 µmol/L) and the difference was significant by paired t-test (pnutritional status of vitamin C, further investigation of association between serum ascorbic acid level and diabetes and smoking by the level of vitamin C consumption is warranted. PMID:20924142

  8. Radionuclide methods of diagnosing anthracycline - induced cardiotoxity

    Anthracycline chemotherapeutic agents play an important role in tumor treatment owing to their high therapeutic efficiency but at the same time they cause lesions to healthy tissues and organs among which cardiotoxity is the most significant. Radionuclide diagnostic methods are widely used in diagnosing heart damage against the background of therapy with anthracyclines. Radionuclide ventriculography is implemented in practice as a routine procedure for serial evaluation of LVFI (left ventricular filling index) and regional myocardial kinetics monitoring. The obtained results are used for individual assessment of the cumulative dose of the anthracycline antineoplastic agent administered. However, the method has low prognostic value regarding the severity of myocardial impairment on account of its late positiveness. Researches along these lines are focused on radiopharmaceuticals accumulating in the myocardial cell and mirroring its perfusion, innervation and vitality, such as 111In-antimyosin, 123I-MIBG and 99mTc-MIBI. Investigations using the aforementioned radiopharmaceuticals disclose the mechanisms of myocardial cell damage under the effect of anthracyclines, becoming positive before clinical manifestation of cardiotoxicity. Their implementation in the routine practice lags behind because of insufficient studies on the issue

  9. Diagnosing Beijing 2020: Mapping the Ungovernable City

    Robin Visser


    Full Text Available Beijing Municipality, characterised by the ‘off-ground’ architecture distinguishing neo-liberal privatisation, is attempting to mitigate the damaging effects of rampant development on the social fabric, cultural heritage, and the environment by adopting sustainable urban planning. I argue that the sustainability rhetoric in the Beijing Municipality 2020 Plans functions in part as strategic metaphors masking unnamed, imminent threats to governance. In this article I diagnose four Beijing plans (Beijing 2006-2015 ‘Rail Transit Plan’ for Compact City, Beijing 2005-2020 ‘Underground Space Plan’ for Alternative Space, Beijing 2006-2020 ‘Undeveloped Area Plan’ for Ecological Responsibility, and Beijing 2006-2010 ‘Low-income Housing Plan’ for Affordability and Liveability. A diagrammatics of the plans illuminates not so much a mapping of Beijing’s future as the forms of spontaneity preoccupying the nation at this historical juncture. The Beijing 2020 plan, as city mapping more generally, discloses the imminence of ungovernable city. The fact that citizens are demanding greater authority over Beijing governance suggests that radical alterations to its urban fabric and quality of life have incited the imminent sociability that is the city.

  10. Diagnoses of corticobasal syndrome and corticobasal degeneration.

    Shimohata, Takayoshi; Aiba, Ikuko; Nishizawa, Masatoyo


    Experts use the term corticobasal syndrome (CBS) for patients with a clinical diagnosis of corticobasal degeneration (CBD), and reserve CBD for those whose conditions have been diagnosed on the basis of neuropathological analyses. Several studies demonstrated that patients with CBD may also present with progressive supranuclear syndrome (PSPS), aphasia, Alzheimer disease-like dementia or behavioral change, suggesting that CBS is merely one of the presenting phenotypes of CBD. Although previous CBD diagnostic criteria reflected only CBS, the international consortium proposed new diagnostic criteria for CBD in 2013 (Armstrong's criteria). The new criteria include 4 CBD subtypes; CBS, frontal behavioral-spatial syndrome (FBS), nonfluent/agrammatic variant of primary progressive aphasia (naPPA),and PSPS. These subtypes were combined to create 2 sets of criteria: more specific clinical research criteria for probable CBD (cr-CBD) and broader criteria for possible CBD that are more inclusive but have a higher chance to detect other tau-based pathologies (p-CBD). Two studies have already revealed that the sensitivity and specificity of the criteria were not high. Because therapeutic interventions that target abnormally-phosphorylated tau have started, further refinement of the criteria is needed via biomarker researches with prospective study designs. PMID:26876110

  11. Diagnosing clostridial enteric disease in poultry.

    Cooper, Kerry K; Songer, J Glenn; Uzal, Francisco A


    The world's poultry industry has grown into a multibillion-dollar business, the success of which hinges on healthy intestinal tracts, which result in effective feed conversion. Enteric disease in poultry can have devastating economic effects on producers, due to high mortality rates and poor feed efficiency. Clostridia are considered to be among the most important agents of enteric disease in poultry. Diagnosis of enteric diseases produced by clostridia is usually challenging, mainly because many clostridial species can be normal inhabitants of the gut, making it difficult to determine their role in virulence. The most common clostridial enteric disease in poultry is necrotic enteritis, caused by Clostridium perfringens, which typically occurs in broiler chickens but has also been diagnosed in various avian species including turkeys, waterfowl, and ostriches. Diagnosis is based on clinical and pathological findings. Negative culture and toxin detection results may be used to rule out this disease, but isolation of C. perfringens and/or detection of its alpha toxin are of little value to confirm the disease because both are often found in the intestine of healthy birds. Ulcerative enteritis, caused by Clostridium colinum, is the other major clostridial enteric disease of poultry. Diagnosis of ulcerative enteritis is by documentation of typical pathological findings, coupled with isolation of C. colinum from the intestine of affected birds. Other clostridial enteric diseases include infections produced by Clostridium difficile, Clostridium fallax, and Clostridium baratii. PMID:23572451

  12. Computer Assisted Diagnoses for Red Eye (CADRE

    Muhammad Zubair Asghar


    Full Text Available This paper introduces an expert System (ES named as “CADRE-Computer Assisted Diagnoses for Red Eye. Mostly the remote areas of the population are deprived of the facilities of having experts in eye disease. So it is the need of the day to store the expertise of Eye specialists in computers through using ES technology. This ES is a rule-based Expert System that assists in red-eye diagnosis and treatment. The knowledge acquired from literature review and human experts of the specific domain was used as a base for analysis, diagnosis and recommendations. CADRE evaluates the risk factors of 20 eye diseases and works just like an ophthalmologist, which will be useful for students, doctors and researchers as well as to patients. This expert system (ES was developed through using ESTA, VISUAL BASIC, MS-EXCEL, Seagate Crystal Reports and Image Styler. This ES is not limited to the Red-eye diseases but can be extended to all types of eye-diseases.

  13. Using saccades to diagnose covert hepatic encephalopathy.

    Cunniffe, Nicholas; Munby, Henry; Chan, Shona; Saatci, Defne; Edison, Eric; Carpenter, R H S; Massey, Dunecan


    Covert Hepatic Encephalopathy (CHE), previously known as Minimal Hepatic Encephalopathy, is a subtle cognitive defect found in 30-70 % of cirrhosis patients. It has been linked to poor quality of life, impaired fitness to drive, and increased mortality: treatment is possible. Despite its clinical significance, diagnosis relies on psychometric tests that have proved unsuitable for use in a clinical setting. We investigated whether measurement of saccadic latency distributions might be a viable alternative. We collected data on 35 cirrhosis patients at Addenbrooke's Hospital, Cambridge, with no evidence of clinically overt encephalopathy, and 36 age-matched healthy controls. Performance on standard psychometric tests was evaluated to determine those patients with CHE as defined by the World Congress of Gastroenterology. We then compared visually-evoked saccades between those with CHE and those without, as well as reviewing blood test results and correlating saccadic latencies with biochemical parameters and prognostic scores. Cirrhosis patients have significantly longer median saccadic latencies than healthy controls. Those with CHE had significantly prolonged saccadic latencies when compared with those without CHE. Analysis of a cirrhosis patient's saccades can diagnose CHE with a sensitivity of 75 % and a specificity of 75 %. We concluded that analysis of a cirrhosis patient's saccadic latency distributions is a fast and objective measure that can be used as a diagnostic tool for CHE. This improved early diagnosis could direct avoidance of high-risk activities such as driving, and better inform treatment strategies. PMID:25586511

  14. Diagnosing SWOT through Importance-performance Analysis

    Alagirisamy Kamatchi Subbiah Sukumaran


    Full Text Available The aim of the study is to evaluate the performance of the firms surveyed against the importance of the opportunities, threats, strengths and weaknesses applicable to those firms using Importance-Performance analysis. Firms optimize their Strengths, Weaknesses, Opportunities and Threats with the help of SWOT analysis. Martilla and James (1977 popularized the Importance-Performance analysis through their study titled with the same name. Importance-Performance analysis can be used to evaluate the performance against the intention or plan formulated by business or non-business firms. This method is widely used in consumer satisfaction studies and competitor analysis. Quite often right decisions can be taken if the information is presented in a comprehensive and understandable manner and in these contexts, Importance-Performance measure scores well. To the best of the author’s knowledge, Importance-Performance Analysis is used for the first time in the study to diagnose the strengths, weaknesses, opportunities and threats applicable to a firm.

  15. Fetal MRI clues to diagnose cloacal malformations

    Prenatal US detection of cloacal malformations is challenging and rarely confirms this diagnosis. To define the prenatal MRI findings in cloacal malformations. We performed a retrospective study of patients with cloacal malformations who had pre- and post-natal assessment at our institution. Fetal MRI was obtained in six singleton pregnancies between 26 and 32 weeks of gestation. Imaging analysis was focused on the distal bowel, the urinary system and the genital tract and compared with postnatal clinical, radiological and surgical diagnoses. The distal bowel was dilated and did not extend below the bladder in five fetuses. They had a long common cloacal channel (3.5-6 cm) and a rectum located over the bladder base. Only one fetus with a posterior cloacal variant had a normal rectum. Three fetuses had increased T2 signal in the bowel and two increased T1/decreased T2 signal bladder content. All had renal anomalies, four had abnormal bladders and two had hydrocolpos. Assessment of the anorectal signal and pelvic anatomy during the third trimester helps to detect cloacal malformations in the fetus. The specificity for this diagnosis was highly increased when bowel fluid or bladder meconium content was identified. (orig.)

  16. PET in diagnosing exocrine pancreatic cancer

    Despite dramatic improvements in diagnostic imaging (ultrasonography, in particular endoscopic ultrasound, CT, MRI) treatment results of pancreatic cancer are still poor. Due to the lack of early symptoms, most tumors are diagnosed at an advanced stage of disease which excludes curative surgical treatment. FDG-PET has been shown to be effective in detecting pancreatic cancer as well as differentiating benign from malignant pancreatic tumors. Results might be further improved by applying quantitative analyses, in particular kinetic modelling of FDG metabolism. Nevertheless false negative as well as false positive findings may occur. Small lesions (lymphnode or liver metastases < 1 cm) might be missed, furthermore hyperglycemia often present in patients with pancreatic disease might reduce tumor uptake and subsequently tumor detectability by PET. False positive findings were reported in active pancreatitis and some benign tumors. Although PET proved to be superior to CT or ERCP in detecting cancer, clinical relevance of PET is limited due to the absence of therapeutic consequences to be derived from PET. As a consequence PET should only be used in patients with equivocal findings of morphological imaging (CT, ERCP) who are potential candidates for surgical treatment. (orig.)

  17. Diagnosing Anomalous Network Performance with Confidence

    Settlemyer, Bradley W [ORNL; Hodson, Stephen W [ORNL; Kuehn, Jeffery A [ORNL; Poole, Stephen W [ORNL


    Variability in network performance is a major obstacle in effectively analyzing the throughput of modern high performance computer systems. High performance interconnec- tion networks offer excellent best-case network latencies; how- ever, highly parallel applications running on parallel machines typically require consistently high levels of performance to adequately leverage the massive amounts of available computing power. Performance analysts have usually quantified network performance using traditional summary statistics that assume the observational data is sampled from a normal distribution. In our examinations of network performance, we have found this method of analysis often provides too little data to under- stand anomalous network performance. Our tool, Confidence, instead uses an empirically derived probability distribution to characterize network performance. In this paper we describe several instances where the Confidence toolkit allowed us to understand and diagnose network performance anomalies that we could not adequately explore with the simple summary statis- tics provided by traditional measurement tools. In particular, we examine a multi-modal performance scenario encountered with an Infiniband interconnection network and we explore the performance repeatability on the custom Cray SeaStar2 interconnection network after a set of software and driver updates.

  18. Pitfalls in diagnosing diabetic foot infections.

    Peters, Edgar J


    Although the diagnosis of a diabetic foot infection is made based on clinical symptoms and signs, we also use blood laboratory, microbiological and radiological studies to make treatment decisions. All of these diagnostic studies have pitfalls that can lead to a delay in diagnosis. Such delays will likely lead to further tissue damage and to a higher chance of amputation. One of these pitfalls is that some clinicians rely on microbiological, rather than clinical data, to diagnose infection. Though subjective by nature, clinical signs predict outcome of foot infections accurately. Another pitfall is that microbiological data can be misleading. All wounds harbour microorganisms; therefore, a positive wound culture does not mean that a wound is infected. Furthermore, the outcome of cultures of wound swabs does not correlate well with culture results of tissue biopsies. Therapy guidance by wound swab will likely lead to overtreatment of non-pathogenic organisms. Genotyping might have a role in identifying previously unrecognized (combinations of) pathogens in diabetic foot infection, bacteria in sessile phenotype and non-culturable pathogens, e.g. in cases where antibiotics have already been administered. One more pitfall is that the diagnosis of osteomyelitis remains difficult. Although the result of percutaneous bone biopsy is the reference standard for osteomyelitis, some other diagnostic modalities can aid in the diagnosis. A combination of several of these diagnostic tests is probably a good strategy to achieve a higher diagnostic accuracy. Relying on a single test will likely lead to misidentification of patients with osteomyelitis with associated overtreatment and undertreatment. PMID:26813617

  19. Incarcerated diaphragmatic hernia--differential diagnoses.

    Bukvić, Nado; Versić, Ana Bosak; Bacić, Giordano; Gusić, Nadomir; Nikolić, Harry; Bukvić, Frane


    The incarceration of diaphragmatic hernia is very rare. We present a case of a four-year-old girl who developed the incarceration of left-sided diaphragmatic hernia, who, until then, was completely asymptomatic. This incarceration of the hernia represented a surgical emergency presenting as obstructive ileus and a severe respiratory distress which developed from what appeared to be full health. During a brief pre-operative examination a number of differential diagnoses were suggested. Along with the laboratory blood analysis (complete blood count and acid-base balance) a plain thoracic and abdominal radiography was done (babygram). After that, through an inserted nasal-gastric tube, barium meal of the upper gastrointestinal tract was done, showing abdominal organs in the left half of the thorax and a significant shift of the mediastinum to the right. With an urgent upper medial laparotomy we accessed the abdominal cavity and made the correct diagnosis. An opening was shown in the rear part of the left hemi-diaphragm with thickened and edematous edges, approx. 6 cm in diameter with incarcerated content. The incarcerated abdominal organs (stomach, transversal colon, small intestine and spleen) gradually moved into the abdominal cavity. The opening was closed with nonresorptive sutures (TiCron) size 2-0 with aprevious control and ventilated expansion of the well-developed left lung. In postoperative course the acid-base balance quickly recovered, as well as the general state of the patient and radiography showed a good expansion and lucency of the lung parenchyma and a return of the mediastinum into the middle part of the thorax. PMID:25842758

  20. Diagnosing delayed ettringite formation in concrete structures

    There has been a number of cases involving deteriorated concrete structures in North America where there has been considerable controversy surrounding the respective contributions of alkali-silica reaction (ASR) and delayed ettringite formation (DEF) to the observed damage. The problem arises because the macroscopic symptoms of distress are not unequivocal and microscopical examinations of field samples often reveal evidence of both processes making it difficult to separate the individual contributions. This paper presents the results of an investigation of a number of concrete columns carrying a raised expressway in North America; prior studies had implicated both DEF and ASR as possible causes of deterioration. Although the columns were not deliberately heat-cured, it is estimated that the peak internal temperature would have exceeded 70 deg. C and perhaps even 80 deg. C, in some cases. The forensic investigation included scanning electron microscopy with energy-dispersive X-ray analysis and expansion testing of cores extracted from the structure. Small-diameter cores stored in limewater expanded significantly (0.3 to 1.3%) and on the basis of supplementary tests on laboratory-produced concrete specimens it was concluded that expansion under such conditions is caused by DEF as the conditions of the test will not sustain ASR. In at least one column, DEF was diagnosed as the sole contributory cause of damage with no evidence of any contribution from ASR or any other deterioration process. In other cases, both ASR and DEF were observed to have contributed to the apparent damage. Of the columns examined, only concrete containing fly ash appeared to be undamaged. The results of this study confirm that, under certain conditions, the process of DEF (acting in isolation of other processes) can result in significant deterioration of cast-in-place reinforced concrete structures

  1. Semistructured Interview for Seizure Classification: Agreement with Physicians’ Diagnoses

    Ottman, Ruth; Hauser, W. Allen; Stallone, Lillian


    A semi-structured interview was developed for classification of seizures in accordance with the 1981 International League Against Epilepsy (ILAE) criteria. The interview was administered over the telephone by trained lay interviewers. Interview-based diagnoses for 50 patients were compared with independent diagnoses by neurologists who also use the ILAE system for seizure classification. Interview diagnoses agreed with those of physicians for broad seizure-type classifications (i.e., partial ...

  2. Dressing up nursing diagnoses: a critical-thinking strategy.

    Sedlak, C A; Ludwick, R


    Teaching nursing diagnoses to beginning students who have no clinical experiences challenges educators to use their creative energies in developing strategies that facilitate students' critical-thinking skills. Dressing Up Nursing Diagnoses is a fun and creative classroom teaching strategy you can use during the Halloween season to help beginning students formulate nursing diagnoses. Two nurse educators describe their successful experiences with this unique teaching strategy. PMID:8718155

  3. Effiziente Diagnose von verteilten Funktionen automobiler Steuergeräte

    Kohl, Jens


    In der Dissertation wird eine Methodik vorgestellt mit dem Ziel, die Effizienz der automobilen Diagnose zu erhöhen. Hierzu gehört die Beherrschung der zunehmenden Komplexität der Diagnose bei gleichzeitiger Senkung ihrer Kostenfaktoren. Somit wird der Zielkonflikt zwischen Kosten und Güte der Diagnose bewältigt. Grundlage für den Ansatz ist eine Analyse der gegenwärtigen Diagnose auf Kosten- und Qualitätspotentiale. Es handelt sich um einen formalen, modellbasierten Diagnoseansatz, der für al...

  4. Initiating events frequency determination

    The paper describes work performed for the Nuclear Power Station (NPS). Work is related to the periodic initiating events frequency update for the Probabilistic Safety Assessment (PSA). Data for all relevant NPS initiating events (IE) were reviewed. The main focus was on events occurring during most recent operating history (i.e., last four years). The final IE frequencies were estimated by incorporating both NPS experience and nuclear industry experience. Each event was categorized according to NPS individual plant examination (IPE) initiating events grouping approach. For the majority of the IE groups, few, or no events have occurred at the NPS. For those IE groups with few or no NPS events, the final estimate was made by means of a Bayesian update with general nuclear industry values. Exceptions are rare loss-of-coolant-accidents (LOCA) events, where evaluation of engineering aspects is used in order to determine frequency.(author)

  5. Initial external events: floods

    The initial external event, specifically flood in a Nuclear power plant, and the calculation necessary to determine the contribution of this type of event in a Probabilistic Safety Analysis, are presented. (M.I.)

  6. Traumatic events and children

    ... over and over are: Physical or emotional abuse Sexual abuse Gang violence War Terrorist events ... Force on Community Preventive Services. The effectiveness of interventions to reduce psychological harm from traumatic events among ...

  7. Surgical Excision of Benign Papillomas Diagnosed with Core Biopsy: A Community Hospital Approach

    Our goal was to assess the value of surgical excision of benign papillomas of the breast diagnosed on percutaneous core biopsy by determining the frequency of upgrade to malignancies and high risk lesions on a final surgical pathology. We reviewed 67 patients who had biopsies yielding benign papilloma and underwent subsequent surgical excision. Surgical pathology of the excised lesions was compared with initial core biopsy pathology results. 54 patients had concordant benign core and excisional pathology. Cancer (ductal carcinoma in situ and invasive ductal carcinoma) was diagnosed in five (7%) patients. Surgery revealed high-risk lesions in 8 (12%) patients, including atypical ductal hyperplasia, atypical lobular hyperplasia, and lobular carcinoma in situ. Cancer and high risk lesions accounted for 13 (19%) upstaging events from benign papilloma diagnosis. Our data suggests that surgical excision is warranted with core pathology of benign papilloma

  8. Bike Race Event

    Hasan, M. Mehedi


    In this workshop project, our intention is to arrange a Bike race event for the bike club’s members. Our project is based upon through a market research of Bike race event market. After analysing the market we have done a plan for our event, which structured by different tools of the project management, such as WBS, RBS etc. project management is the key tool in this project. Lastly we have shown our budget and financial structure of the event.

  9. Advertising Effectiveness In Events

    Jain, Sushilkumar


    Confronted with decreasing effectiveness of the classic marketing communications, events have become an increasingly popular alternative for marketers. Events constitute one of the most exciting and fastest growing forms of leisure and business. With time, the decreasing effectiveness of classical marketing communications boosted the use of events for marketing and making brand awareness. Event marketing is seen as the unique opportunity to integrate the firm’s communication activities like p...

  10. Event generators at BESⅢ

    PING Rong-Gang


    We present a brief remark and introduction to event generators for tau-charm physics currently used at BESⅢ,including KKMC,BesEvtGen,Bhlumi,Bhwide,Babayaga and inclusive Monte-Carlo event generators.This paper provides basic information on event generators for BESⅢ users.

  11. Event matrix system

    The number of background events in nuclear and particle physics experiments which use multiwire proportional chambers can be extremely high. Using a computer to resolve these events results in a high deadtime for the experiment. A fast matrix system for decreasing the number of background events is described in this report. 4 figures

  12. Lamotrigine versus carbamazepine in treating newly diagnosed epilepsy:A meta-analysis

    LIU Ya; PENG Ya-Wen; ZHOU Ke-Cheng; QU Cheng-Hao; HU Wei


    First-line therapy for newly diagnosed epilepsy (e.g. carbamazepine)is generally considered effective.However,in a significant proportion of patients (especially in the elderly),us-age may be limited by unwanted adverse events.To synthesize ev-idence regarding efficacy and tolerability of lamotrigine as first line, monotherapy or prophylactic antiepileptic. MEDLINE, PsycINFO,Scopus,EMBASE,and the Cochrane Central Register of Controlled Trials (CENTRAL)were searched from inception to June 2014.Randomised controlled trials (RCTs)comparing lam-otrigine with carbamazepine monotherapy for newly diagnosed epi-lepsy.Eligible studies were independently selected and methodo-logical quality was independently evaluated by two reviewers. Effects were summarized using standardized hazard ratio (HR)or odds ratio (OR)with suitable effect models.Pre-specified sensi-tivity analyses were performed to explain heterogeneity.Nine stud-ies involving 2793 participants met the inclusion criteria.The effects of lamotrigine compared with carbamazepine in patients with newly diagnosed seizures were investigated in all studies.We found that carbamazepine was inferior in comparison to lamotrigine when measuring the proportion of remaining seizure free in the elderly (hazard ratio (HR)1.71;95%confidence interval (CI) 1.27 to 2.29)but notthe children and the adult.There was strong evidence for the tolerability profile of lamotrigine compared with carbamazepine in the Retention rates (HR 1 .67;95%CI 1 . 43 to 1.94).Moreover,lamotrigine lead to less adverse events. Lamotrigine and carbamazepine showed similar efficacy on newly diagnosed epilepsy but better efficacy in the elderly than carbam-azepine.Furthermore,lamotrigine was better tolerated.

  13. Clinical analysis of 135 newly diagnosed patients with Hodgkin lymphoma



    Objective To investigate the clinical characteristics,therapeutic effects,long-term survival and prognostic factors of the newly diagnosed patients with Hodgkin lymphoma(HL).Methods One hundred and thirty five newly diagnosed HL patients in West China hospital from January 1,2000 to December 31,2010 were analyzed retrospectively.Software SPSS18.0 was applied to deter-

  14. Collective Thomson scattering capabilities to diagnose fusion plasmas

    Korsholm, Søren Bang; Bindslev, Henrik; Furtula, Vedran;


    Collective Thomson scattering (CTS) is a versatile technique for diagnosing fusion plasmas. In particular, experiments on diagnosing the ion temperature and fast ion velocity distribution have been executed on a number of fusion devices. In this article the main aim is to describe the technique...

  15. Hospital-diagnosed dementia and suicide: a longitudinal study using prospective, nationwide register data

    Erlangsen, Annette; Zarit, S.H.; Conwell, Yeates


    OBJECTIVE: The current study aims to examine the risk of suicide in persons diagnosed with dementia during a hospitalization and its relationship to mood disorders. DESIGN: Event-history analysis using time-varying covariates. SETTING: Population-based record linkage. PARTICIPANTS: All individuals...... aged 50+ living in Denmark (N=2,474,767) during January 1, 1990 through December 31, 2000. MEASUREMENTS: Outcome of interest is suicide. Relative risks are calculated based on person-days spent in each stratum. RESULTS: A total of 18,648,875 person-years were observed during the 11-year study period...

  16. An Event-Based Approach to Distributed Diagnosis of Continuous Systems

    Daigle, Matthew; Roychoudhurry, Indranil; Biswas, Gautam; Koutsoukos, Xenofon


    Distributed fault diagnosis solutions are becoming necessary due to the complexity of modern engineering systems, and the advent of smart sensors and computing elements. This paper presents a novel event-based approach for distributed diagnosis of abrupt parametric faults in continuous systems, based on a qualitative abstraction of measurement deviations from the nominal behavior. We systematically derive dynamic fault signatures expressed as event-based fault models. We develop a distributed diagnoser design algorithm that uses these models for designing local event-based diagnosers based on global diagnosability analysis. The local diagnosers each generate globally correct diagnosis results locally, without a centralized coordinator, and by communicating a minimal number of measurements between themselves. The proposed approach is applied to a multi-tank system, and results demonstrate a marked improvement in scalability compared to a centralized approach.

  17. Do clinical diagnoses correlate with pathological diagnoses in cardiac transplant patients? The importance of endomyocardial biopsy

    Luk, Adriana; Metawee, Mohammed; Ahn, Eric;


    BACKGROUND: Heart transplantation remains the last treatment option for patients with end-stage cardiac disease. Such diseases include ischemic cardiomyopathy, nonischemic cardiomyopathy and other conditions such as arrhythmogenic right ventricular dysplasia, cardiac sarcoidosis and cardiac...... amyloidosis. OBJECTIVE: To review the changes that have occurred over time in the etiology of heart disease in patients requiring heart transplantation, and to compare the clinical and histological diagnoses of explanted hearts from patients with progressive cardiac disease. METHODS: The pathological findings...... of 296 surgically excised hearts over a 20-year period (January 1987 to July 2006) at one institution were examined. Patients were separated into groups based on year of heart transplantation. The tissue was examined to determine the underlying cardiac pathology leading to congestive heart failure...

  18. Long-term tolerability of once-monthly injectable paliperidone palmitate in subjects with recently diagnosed schizophrenia

    Sliwa JK


    Full Text Available Jennifer Kern Sliwa,1 Cynthia A Bossie,1 Dong-Jing Fu,1 Ibrahim Turkoz,2 Larry Alphs11Janssen Scientific Affairs LLC, 2Janssen Research and Development, LLC, Titusville, NJ, USABackground: A post hoc analysis from a multiphase trial with open-label transition and maintenance phases, a double-blind relapse prevention phase, and an optional open-label extension examined the long-term tolerability with continuous once-monthly injectable paliperidone palmitate 39, 78, 117, or 156 mg (25, 50, 75, or 100 mg equivalents [mg eq] of paliperidone in subjects with recently diagnosed (≤5 years; n = 216 versus chronic illness (>5 years; n = 429 schizophrenia.Methods: Adverse events reported at a ≥2% margin between subgroups were identified. Relative risks (in the recently diagnosed compared with the chronically ill and 95% confidence intervals (CI were determined, and CI not including 1 were considered potentially significant.Results: In both subgroups, the mean monthly dose was 109 mg (69.9 mg eq. Continuous mean exposures were 333.9 ± 271.9 and 308.7 ± 278.3 days in the recently diagnosed and chronic illness subgroups, respectively. Using the criteria outlined in the methods, nasopharyngitis was a potentially significant event reported in more chronically ill than recently diagnosed subjects at months 6, 9, 12, and endpoint (7.2% versus 2.8%; relative risk 0.384; 95% CI 0.163–0.907. Influenza (2.8% versus 0.7%; relative risk 3.9; 95% CI 1.003–15.730 and amenorrhea (3.2% versus 0.9%; relative risk 3.476; 95% CI 1.029–11.744 at endpoint were potentially significant events in more recently diagnosed than chronically ill subjects. Mean weight changes, sedation/somnolence, any extrapyramidal symptom-related or glucose-related events were generally similar between the groups. The mean prolactin level increased in both sexes in both subgroups (changes from baseline of +41.8 ng/mL and +26.5 ng/mL in recently diagnosed and chronic illness females and

  19. A Fast Test to Diagnose Flu

    Hazi, A U


    People with flu-like symptoms who seek treatment at a medical clinic or hospital often must wait several hours before being examined, possibly exposing many people to an infectious virus. If a patient appears to need more than the routine fluids-and-rest prescription, effective diagnosis requires tests that must be sent to a laboratory. Hours or days may pass before results are available to the doctor, who in the meantime must make an educated guess about the patient's illness. The lengthy diagnostic process places a heavy burden on medical laboratories and can result in improper use of antibiotics or a costly hospital stay. A faster testing method may soon be available. An assay developed by a team of Livermore scientists can diagnose influenza and other respiratory viruses in about two hours once a sample has been taken. Unlike other systems that operate this quickly, the new device, called FluIDx (and pronounced ''fluidics''), can differentiate five types of respiratory viruses, including influenza. FluIDx can analyze samples at the point of patient care--in hospital emergency departments and clinics--allowing medical providers to quickly determine how best to treat a patient, saving time and potentially thousands of dollars per patient. The FluIDx project, which is led by Livermore chemist Mary McBride of the Physics and Advanced Technologies Directorate, received funding from the National Institute of Allergy and Infectious Diseases and the Laboratory Directed Research and Development (LDRD) Program. To test the system and make it as useful as possible, the team worked closely with the Emergency Department staff at the University of California (UC) at Davis Medical Center in Sacramento. Flu kills more than 35,000 people every year in the US. The 2003 outbreak of severe acute respiratory syndrome and the ongoing concern about a possible bird flu pandemic show the need for a fast, reliable test that can differentiate seasonal flu from a

  20. Depression diagnoses following the identification of bipolar disorder: costly incongruent diagnoses

    Schultz Jennifer F


    Full Text Available Abstract Background Previous research has documented that the symptoms of bipolar disorder are often mistaken for unipolar depression prior to a patient's first bipolar diagnosis. The assumption has been that once a patient receives a bipolar diagnosis they will no longer be given a misdiagnosis of depression. The objectives of this study were 1 to assess the rate of subsequent unipolar depression diagnosis in individuals with a history of bipolar disorder and 2 to assess the increased cost associated with this potential misdiagnosis. Methods This study utilized a retrospective cohort design using administrative claims data from 2002 and 2003. Patient inclusion criteria for the study were 1 at least 2 bipolar diagnoses in 2002, 2 continuous enrollment during 2002 and 2003, 3 a pharmacy benefit, and 4 age 18 to 64. Patients with at least 2 unipolar depression diagnoses in 2003 were categorized as having an incongruent diagnosis of unipolar depression. We used propensity scoring to control for selection bias. Utilization was evaluated using negative binomial models. We evaluated cost differences between patient cohorts using generalized linear models. Results Of the 7981 patients who met all inclusion criteria for the analysis, 17.5% (1400 had an incongruent depression diagnosis (IDD. After controlling for background differences, individuals who received an IDD had higher rates of inpatient and outpatient psychiatric utilization and cost, on average, an additional $1641 per year compared to individuals without an IDD. Conclusions A strikingly high proportion of bipolar patients are given the differential diagnosis of unipolar depression after being identified as having bipolar disorder. Individuals with an IDD had increased acute psychiatric care services, suggesting higher levels of relapses, and were at risk for inappropriate treatment, as antidepressant therapy without a concomitant mood-stabilizing medication is contraindicated in bipolar

  1. CT-MPR invaluable in diagnosing odontogenic maxillary sinusitis

    In everyday examination, it is usual to encounter odontogenic maxillary sinusitis patients. Odontogenic maxillary sinusitis is generally best diagnosed by dental X-ray imaging. Many medical facilities not having a dental X-ray unit use coronal computed tomography (CT) images to diagnose odontogenic maxillary sinusitis. Coronal CT imaging causes artifacts, however due to dental prosthesises. Computed tomography-Multiplanar reformation (CT-MPR) imaging has proved useful in evaluating the paranasal sinus because it is not influenced by dental prosthesises. We evaluated the usefulness of CT-MPR for diagnosing odontogenic maxillary sinusitis by retrospectively analyzing 16 patients, with the following results. We couldn't diagnose all cases of odontogenic maxillary sinusitis in posteroanterior and Waters projection images. Panoramic radiography is needed to diagnose odontogenic maxillary sinusitis. Dental X-ray imaging missed some cases, but all cases were diagnosed by CT-MPR imaging, giving a 100% diagnosestic rate. CT-MPR imaging is thus at least as valuable or better than dental X-ray imaging in diagnosing odontogenic maxillary sinusitis. (author)

  2. Event sponsorship in China

    Y. Fan; Pfitzenmaier, N


    Event marketing is currently at the infant stage in China, but holds a great potential in future. This is concluded from an Internet-based survey. The respondents believe that event marketing provides international companies with a viable alternative to the increasingly cluttered mass media, and plays a key role in the integrated marketing communications (IMC). Sponsoring sports and music events is found particularly effective in reaching the opinion leaders and innovators, and establishing f...


    R N Chatterjee; Mukherjee, S. P.; Nandi, D.N.


    SUMMARY The life events occurring in a 6 month period preceding onset of illness in 50 OPD primary depressives were inquired into by a Life Events Inventory and compared with those in a corresponding time period of 50 matched controls. The relation between life events and the depth of depression at initial interview was also studied. The results are analysed and the probable pitfalls discussed.

  4. Event Detection in Tweets

    Houssem Eddine Dridi

    Full Text Available We present a system for finding, from Twitter data, events that raised the interest of users within a given time period and the important dates for each event. An event is represented by many terms whose frequency increases suddenly at one or more moments during the analysed period. In order to determine the terms (especially the hashtags dealing with a topic, we propose methods to cluster similar terms: phonetic methods adapted to the writing mode used by users and some statistical methods. In order to select the set of events, we used three main criteria: frequency, variation and Tf*Idf.

  5. Safeguards summary event list (SSEL)

    The List contains nine categories of events involving NRC licensed material or licensees. It is deliberately broad in scope for two main reasons. First, the list is designed to serve as a reference document. It is as complete and accurate as possible. Second, the list is intended to provide as broad a perspective of the nature of licensee-related events as possible. The nine categories of events are as follows: bomb-related events; intrusion events; missing and/or allegedly stolen events; transportation-related events; vandalism events; arson events; firearms-related events; sabotage events; and miscellaneous events

  6. Features, Events, and Processes: Disruptive Events

    J. King


    The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report.

  7. Features, Events, and Processes: Disruptive Events

    The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report

  8. Features, Events, and Processes: Disruptive Events

    The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA)

  9. Features, Events, and Processes: Disruptive Events

    P. Sanchez


    The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA).

  10. The ATLAS Event Builder

    Vandelli, W; Battaglia, A; Beck, H P; Blair, R; Bogaerts, A; Bosman, M; Ciobotaru, M; Cranfield, R; Crone, G; Dawson, J; Dobinson, Robert W; Dobson, M; Dos Anjos, A; Drake, G; Ermoline, Y; Ferrari, R; Ferrer, M L; Francis, D; Gadomski, S; Gameiro, S; Gorini, B; Green, B; Haberichter, W; Haberli, C; Hauser, R; Hinkelbein, C; Hughes-Jones, R; Joos, M; Kieft, G; Klous, S; Korcyl, K; Kordas, K; Kugel, A; Leahu, L; Lehmann, G; Martin, B; Mapelli, L; Meessen, C; Meirosu, C; Misiejuk, A; Mornacchi, G; Müller, M; Nagasaka, Y; Negri, A; Pasqualucci, E; Pauly, T; Petersen, J; Pope, B; Schlereth, J L; Spiwoks, R; Stancu, S; Strong, J; Sushkov, S; Szymocha, T; Tremblet, L; Ünel, G; Vermeulen, J; Werner, P; Wheeler-Ellis, S; Wickens, F; Wiedenmann, W; Yu, M; Yasu, Y; Zhang, J; Zobernig, H; 2007 IEEE Nuclear Science Symposium and Medical Imaging Conference


    Event data from proton-proton collisions at the LHC will be selected by the ATLAS experiment in a three-level trigger system, which, at its first two trigger levels (LVL1+LVL2), reduces the initial bunch crossing rate of 40~MHz to $sim$3~kHz. At this rate, the Event Builder collects the data from the readout system PCs (ROSs) and provides fully assembled events to the Event Filter (EF). The EF is the third trigger level and its aim is to achieve a further rate reduction to $sim$200~Hz on the permanent storage. The Event Builder is based on a farm of O(100) PCs, interconnected via a Gigabit Ethernet to O(150) ROSs. These PCs run Linux and multi-threaded software applications implemented in C++. All the ROSs, and substantial fractions of the Event Builder and Event Filter PCs have been installed and commissioned. We report on performance tests on this initial system, which is capable of going beyond the required data rates and bandwidths for Event Building for the ATLAS experiment.

  11. The Blayais event

    This document provides the main events occurred to the Blayais installation during the year 2000. For each events, the detailed chronology, the situation analysis, the crisis management and the public information are provided. Some recommendations are also provided by the nuclear safety authorities. (A.L.B.)

  12. Human Performance Event Database

    The purpose of this paper is to describe several aspects of a Human Performance Event Database (HPED) that is being developed by the Nuclear Regulatory Commission. These include the background, the database structure and basis for the structure, the process for coding and entering event records, the results of preliminary analyses of information in the database, and plans for the future. In 1992, the Office for Analysis and Evaluation of Operational Data (AEOD) within the NRC decided to develop a database for information on human performance during operating events. The database was needed to help classify and categorize the information to help feedback operating experience information to licensees and others. An NRC interoffice working group prepared a list of human performance information that should be reported for events and the list was based on the Human Performance Investigation Process (HPIP) that had been developed by the NRC as an aid in investigating events. The structure of the HPED was based on that list. The HPED currently includes data on events described in augmented inspection team (AIT) and incident investigation team (IIT) reports from 1990 through 1996, AEOD human performance studies from 1990 through 1993, recent NRR special team inspections, and licensee event reports (LERs) that were prepared for the events. (author)

  13. Event generator overview

    Due to their ability to provide detailed and quantitative predictions, the event generators have become an important part of studying relativistic heavy ion physics and of designing future experiments. In this talk, the author will briefly summarize recent progress in developing event generators for the relativistic heavy ion collisions

  14. How Do Health Care Providers Diagnose Rett Syndrome?

    ... and Publications How do health care providers diagnose Rett syndrome? Skip sharing on social media links Share this: ... would rule out a Rett syndrome diagnosis. Atypical Rett Syndrome Genetic mutations causing some atypical variants of Rett ...

  15. Treatment of Newly Diagnosed and Recurrent Childhood Brain Tumors

    ... Treatment of Newly Diagnosed and Recurrent Childhood Brain Tumors The brain is made of different kinds of cells . Childhood ... following: What You Need To Know About™ Brain Tumors Pediatric Brain Tumor Consortium (PBTC) For more childhood cancer information ...

  16. Insurance Mandates Boost U.S. Autism Diagnoses

    ... page: Insurance Mandates Boost U.S. Autism Diagnoses Early treatment provides ... the Penn researchers analyzed inpatient and outpatient health insurance claims from 2008 through 2012 for more than ...

  17. How Do Health Care Providers Diagnose Phenylketonuria (PKU)?

    ... and Publications How do health care providers diagnose phenylketonuria (PKU)? Skip sharing on social media links Share this: ... test done on newborns. 1 Newborn Screening for PKU All 50 U.S. states and territories require that ...

  18. Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson's

    ... Parkinson's HelpLine Learn More Science News Salivary Gland Biopsy Shows Promise to Helping to Diagnose Parkinson’s - Mar ... team performed a procedure called a needle core biopsy of the submandibular glands in 15 people who ...

  19. How Do Health Care Providers Diagnose Pregnancy Loss or Miscarriage?

    ... do health care providers diagnose pregnancy loss or miscarriage? Skip sharing on social media links Share this: ... pregnant woman experiences any of the symptoms of miscarriage, such as crampy abdominal or back pain, light ...

  20. How Do Health Care Providers Diagnose Fragile X Syndrome?

    ... and Publications How do health care providers diagnose Fragile X syndrome? Skip sharing on social media links Share this: ... information helps families and providers to prepare for Fragile X syndrome and to intervene as early as possible. Possible ...

  1. Acute Coronary Events

    Arbab-Zadeh, Armin; Nakano, Masataka; Virmani, Renu; Fuster, Valentin


    In the United States alone, more than 400,000 Americans die annually from coronary artery disease and more than 1,000,000 suffer acute coronary events, i.e., myocardial infarction and sudden cardiac death.1 Considering the aging of our population and increasing incidence of diabetes and obesity, the morbidity from coronary artery disease, and its associated costs, will place an increasing, substantial burden on our society.2 Between 2010 and 2030, total direct medical costs spent in the US for cardiovascular diseases are projected to triple from 273 to 818 billion dollars.2 Although effective treatments are available and considerable efforts are ongoing to identify new strategies for the prevention of coronary events, predicting such events in an individual has been challenging.3 In hopes of improving our ability to determine the risk of coronary events, it is prudent to review our knowledge of factors that lead to acute coronary events. PMID:22392862

  2. Follow-up of prenatally diagnosed unilateral hydronephrosis

    Thorup, Jørgen Mogens; Lenz, K; Rabol, A;


    Based on previous experience with prenatally diagnosed unilateral hydronephrosis, we found that the primary indications for surgical intervention should be symptoms or functional impairment of the hydronephrotic kidney. Nonoperative management of neonates without symptoms and with normal function...... of the affected kidney was proposed. However, the strategy of treatment after prenatally diagnosed hydronephrosis is still controversial. We studied 28 consecutive children with suspected unilateral pelviureteral junction obstruction and a normal contralateral kidney. The overall follow-up period...

  3. The organisational diagnoses of a distribution organisation / Lourence Badenhorst Alblas

    Alblas, Lourence Badenhorst


    During the past three decades the economic performances of South Africa organisations were poor. This poor performance forced a lot of South African organisations to look at the way they do business. A method to analyse the way business is conducted through an Organisation Diagnose. Organisation Diagnose is the process of using concepts and methods from the social and behavioural sciences to assess the current state of an entire organisation and to find ways to improve th...

  4. Frequency of nursing diagnoses in a surgical clinic

    Andreza Cavalcanti Vasconcelos; Claudia Germania Alencar de Castro; Durcival Francisco da Silva; Vanessa Juvino de Sousa


    Objective: to identify the frequency of Nursing Diagnoses of patients in a surgical clinic. Methods: cross-sectional study, performed with 99 patients in the postoperative of general surgery. Data were collected through a questionnaire validated according to domains of NANDA International, including physical and laboratory examination. Results: 17 nursing diagnoses were found; eight had a frequency higher than 50.0% (infection risk, impaired tissue integrity, constipation risk, anxiety, bleed...

  5. Circulating tumor cells in newly diagnosed inflammatory breast cancer

    Mego, Michal; Giordano, Antonio; De Giorgi, Ugo; Masuda, Hiroko; Hsu, Limin; Giuliano, Mario; Fouad, Tamer M.; Dawood, Shaheenah; Ueno, Naoto T.; Valero, Vicente; Andreopoulou, Eleni; Alvarez, Ricardo H.; Wendy A Woodward; Hortobagyi, Gabriel N; Cristofanilli, Massimo


    Introduction Circulating tumor cells (CTCs) are an independent prognostic factor for progression-free survival (PFS) and overall survival (OS) in patients with metastatic breast cancer. Inflammatory breast cancer (IBC) is one of the most aggressive forms of breast cancer. The prognostic value of a CTC count in newly diagnosed IBC has not been established. The aim of this study was to assess the prognostic value of a baseline CTC count in patients with newly diagnosed IBC. Methods This retrosp...

  6. Effect of a healthcare gender gap on progression of HIV/AIDS defined by clinical-biological criteria among adults from Cordoba City (Argentina from 1995 to 2005 Condicionamiento de la evolución del VIH/sida definida por criterios clínico-biológicos en adultos de la ciudad de Córdoba (Argentina, de 1995 a 2005, por la brecha sanitaria existente entre ambos sexos

    Elio A. Soria


    Full Text Available Objective: To establish the influence of clinical status at diagnosis and of gender on progression of HIV/AIDS determined by clinical-biological factors in patients from Cordoba City (Argentina from 1995 to 2005. Methods: Gender and clinical and laboratory data were evaluated by descriptive statistics, non-parametric survival analysis, and generalized linear models at the beginning of the study (diagnosis and at the end (hospital records, n=209. Results: At diagnosis, women (n=28, 13.4% had a higher probability of being asymptomatic than men (n=181, 86.6%. High viremia was associated with advanced clinical stages, but was inversely related to CD4 count. Truncated Kaplan-Meier curves were similar for both sexes. The probability of not having AIDS criteria at the end of the study was higher in patients without these criteria at diagnosis. Women had a higher probability of having AIDS at the end of the follow-up than men. In contrast, men had a higher prevalence of venereal diseases (n=38, 21%, dysmetabolic profile (n=14, 7.7% and positive serology for opportunists (n=31, 17.1%. Marker diseases were mainly represented by internal mycosis and waste syndrome, although less specific findings (anemia, oral lesions were also associated with progression. Conclusions: Using an integrative approach, high viremia was critically linked to clinical and lymphocyte impairment. Early diagnosis was a major determinant of clinical course, with women having a worse prognosis. However, men were diagnosed in clinically advanced stages and with other non-HIV-related entities, which could affect progression. These findings should be integrated into the planning of preventive strategies.Objetivos: Establecer la influencia de la condición médica al diagnóstico y del sexo en la evolución del VIH/Sida determinada por factores clínico-biológicos en pacientes de la ciudad de Córdoba (Argentina, 1995-2005. Métodos: El sexo, los datos clínicos y los de laboratorio

  7. "Universe" event at AIMS


    Report of event of 11 May 2008 held at the African Institute of Mathematical Sciences (Muizenberg, Cape), with speakers Michael Griffin (Administrator of NASA), Stephen Hawking (Cambridge), David Gross (Kavli Institute, Santa Barbara) and George Smoot (Berkeley).


    OSEI flood products (FLD) include multichannel color composite imagery and single-channel grayscale imagery of enlarged river areas or increased sediment flow. Typically, these events are displayed by comparison to imagery taken when flooding was not occurring.

  9. Event shape sorting

    Kopečná, Renata; Tomášik, Boris


    We propose a novel method for sorting events of multiparticle production according to the azimuthal anisotropy of their momentum distribution. Although the method is quite general, we advocate its use in analysis of ultra-relativistic heavy-ion collisions where a large number of hadrons is produced. The advantage of our method is that it can automatically sort out samples of events with histograms that indicate similar distributions of hadrons. It takes into account the whole measured histograms with all orders of anisotropy instead of a specific observable ( e.g., v_2 , v_3 , q_2 . It can be used for more exclusive experimental studies of flow anisotropies which are then more easily compared to theoretical calculations. It may also be useful in the construction of mixed-events background for correlation studies as it allows to select events with similar momentum distribution.


    Gautam, Shiv; Kamal, Preet


    SUMMARY Stressful life events preceding neurotic disorders, their impact on neurotic patients in comparison to normal subjects and relationship of impact of stressful life-events to depression and anxiety scores were studied prospectively in 100 consecutive neurotic patients, diagnosed according to ICD-9 and 100 matched normal subjects in psychiatric O.P.D. of S.M.S. Hospital, Jaipur, by administering presumptive stressful life event scale, Beck's depression inventory and Max Hamilton anxiety...