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Sample records for adjusted d-dimer cut-off

  1. Therapeutic significance of a D-dimer cut-off level of >3 μg/ml in colorectal cancer patients treated with standard chemotherapy plus bevacizumab

    The risk of venous thromboembolism has been reported to increase when receiving bevacizumab. Many cancer patients are reported to have elevated D-dimer levels. It is not clear what D-dimer level might indicate an increased risk of venous thromboembolism in the colorectal cancer patients treated with bevacizumab-containing chemotherapy. The D-dimer levels and any event concurrent with an elevated D-dimer level were evaluated in patients receiving bevacizumab. The D-dimer cut-off level was determined using the receiver-operating characteristic analysis. The selection criteria were as follows: histologically proven metastatic and unresectable colorectal adenocarcinoma; no prior chemotherapy containing bevacizumab; D-dimer test performed repetitively on the baseline and during bevacizumab administration; no venous thromboembolism identified at the baseline; and enhanced computed tomographic scan performed every 2 months. Sixty-nine patients were included. The chemotherapy regimens with bevacizumab included the regimen of 5-fluorouracil, leucovorin and oxaliplatin (FOLFOX), the regimen of 5-fluorouracil, leucovorin and irinotecan (FOLFIRI), and leucovorin-modulated 5-fluorouracil. The median baseline D-dimer level was 1.2 μg/ml. The appropriate D-dimer cut-off level was 3 μg/ml with the negative predictive value of 98% and relative risk of 6.9. Twenty-one of 69 patients showed elevated D-dimer levels of >3 μg/ml, with 11 patients for unknown reasons, 6 with tumor progression, 3 with venous thromboembolism and 1 with sepsis. In the remaining 48 patients whose D-dimer levels were ≤3 μg/ml, only one patient developed a venous thromboembolism. A D-dimer cut-off level of 3 μg/ml might be a useful indicator level to exclude venous thromboembolism or show an increased risk for venous thromboembolism in colorectal cancer patients treated with bevacizumab-containing chemotherapy. (author)

  2. Age-dependent D-dimer cut-off to avoid unnecessary CT-exams for ruling-out pulmonary embolism

    To evaluate the effect of an age-dependent D-Dimer cut-off in patients who underwent a computed tomography pulmonary angiogram (CTPA) for suspected pulmonary embolism (PE). Retrospective application of an age-dependent D-dimer cut-off (age/100 in patients aged over 50) in 530 consecutive patients, both in- and outpatients, aged over 18, who underwent CTPA for suspected PE according to the guidelines. The application of an age-dependent D-dimer cut-off showed a now negative test-result in 17 of 530 patients (3.2 %). The proportion was 4.1 % (17 of 418) in patients aged over 50. None of these 17 cases was diagnosed with PE in CTPA, the false-negative rate was 0 %. The effect could be seen in outpatients (14 of 377 [3.7 %]) as well as in inpatients(3 of 153 [2.0 %]) with no statistically significant difference (p > 0.05). The application of an age-dependent D-dimer cut-off as part of the guideline-based algorithm for suspected PE reduced the number of necessary CTPA in outpatients as well as in inpatients.

  3. Age-dependent D-dimer cut-off to avoid unnecessary CT-exams for ruling-out pulmonary embolism; Altersangepasste Anhebung des D-Dimer-Grenzwertes zur Vermeidung unnoetiger CT-Untersuchungen bei Verdacht auf Lungenarterienembolie

    Altmann, M.M.; Hoehne, M.; Herold, T. [HELIOS Klinikum Berlin-Buch (Germany). Radiology; Wrede, C.E. [HELIOS Klinikum Berlin-Buch (Germany). Emergency Department; Peetz, D. [HELIOS Klinikum Berlin-Buch (Germany). Laboratory Medicine; Stroszczynski, C. [University Medical Center, Radiology, Regensburg (Germany)

    2015-09-15

    To evaluate the effect of an age-dependent D-Dimer cut-off in patients who underwent a computed tomography pulmonary angiogram (CTPA) for suspected pulmonary embolism (PE). Retrospective application of an age-dependent D-dimer cut-off (age/100 in patients aged over 50) in 530 consecutive patients, both in- and outpatients, aged over 18, who underwent CTPA for suspected PE according to the guidelines. The application of an age-dependent D-dimer cut-off showed a now negative test-result in 17 of 530 patients (3.2 %). The proportion was 4.1 % (17 of 418) in patients aged over 50. None of these 17 cases was diagnosed with PE in CTPA, the false-negative rate was 0 %. The effect could be seen in outpatients (14 of 377 [3.7 %]) as well as in inpatients(3 of 153 [2.0 %]) with no statistically significant difference (p > 0.05). The application of an age-dependent D-dimer cut-off as part of the guideline-based algorithm for suspected PE reduced the number of necessary CTPA in outpatients as well as in inpatients.

  4. How to use D-dimer in acute cardiovascular care

    Giannitsis, Evangelos; Mair, Johannes; Christersson, Christina;

    2015-01-01

    and subsequent degradation of cross-linked fibrin by plasmin. Many different assays for D-dimer testing are currently used in routine care. However, these tests are neither standardized nor harmonized. Consequently, only clinically validated assays and assay specific decision limits should be used for routine...... testing. For the exclusion of pulmonary embolism/deep vein thrombosis, age-adjusted cut-offs are recommend. Clinicians must be aware of the validated use of their hospital's D-dimer assay to avoid inappropriate use of this biomarker in routine care.......D-dimer testing is important to aid in the exclusion of venous thromboembolic events (VTEs), including deep venous thrombosis and pulmonary embolism, and it may be used to evaluate suspected aortic dissection. D-dimer is produced upon activation of the coagulation system with the generation...

  5. Global Emergency Medicine Journal Club: A Social Media Discussion About the Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism Trial

    Rezaie, SR; Swaminathan, AK; Chan, T.; Shaikh, S; Lin, M.

    2015-01-01

    © 2015 American College of Emergency Physicians. Study objective: Annals of Emergency Medicine collaborated with an educational Web site, Academic Life in Emergency Medicine (ALiEM), to host an online discussion session featuring the 2014 Journal of the American Medical Association publication on the Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism (ADJUST-PE) trial by Righini et al. The objective is to describe a 14-day (August 25 to September 7, 2014) worldwide academic dia...

  6. Automatic velocity control in cutting-off machines

    Machado, Carlos; Fonseca, Jaime C.; Mendes, José A.

    2003-01-01

    Usually, automatic cutting-off machines, of metallic pipes or bars, use constant cutting velocity. This mode of operation, constant cutting velocity combined with different profiles of materials to be cut, causes variable cutting forces to be applied to the saw. As a result, the cutting off machine is generally set for the worst expected conditions, otherwise excessive wear of the saw and machine will occur. Further, traditional cutting-off machines require adjustments to be made in order to ...

  7. Intelligent cutting-off of pipes and bars

    Machado, Carlos; Mendes, José A.; Fonseca, Jaime C.

    2003-01-01

    Traditionally, automatic cutting-off machines, of metallic pipes or bars, use a constant cutting velocity mode. This mode of operation, constant cutting velocity combined with different profiles of materials to be cut, exposes the cutting saw to variable cutting forces. Therefore, the cutting off machine is usually set for the worst expected conditions, otherwise excessive wear of the saw and machine will occur. Further, traditional cutting-off machines require the adjust...

  8. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation

    Cervellin, Gianfranco, E-mail: gcervellin@ao.pr.it; Bonfanti, Laura; Picanza, Alessandra; Lippi, Giuseppe [1Academic Hospital of Parma (Italy)

    2015-03-15

    D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF). To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98) had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004). The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029). An inverse and highly significant correlation was found between serum potassium and D-dimer (r = −0.21; p < 0.001), even after adjustments for age and sex (beta coefficient −94.8; p = 0.001). The relative risk for a positive D-dimer value attributed to hypokalemia was 1.64 (95% CI, 1.02 to 2.63; p = 0.040). The correlation remained statistically significant in patients free from antihypertensive drugs (r = −0.25; p = 0.018), but not in those taking angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics. The inverse correlation between values of potassium and D-dimer in patients with AAF provides important and complementary information about the thromboembolic risk of these patients.

  9. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation

    Gianfranco Cervellin

    2015-03-01

    Full Text Available Background: D-dimer values are frequently increased in patients with atrial fibrillation (AF compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. Objective: D-dimer values are frequently increased in patients with atrial fibrillation (AF compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF. Methods: To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Results: Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98 had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004. The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029. An inverse and highly significant correlation was found between serum potassium and D-dimer (r = −0.21; p < 0.001, even after adjustments for age and sex (beta coefficient −94.8; p = 0.001. The relative risk for a positive D-dimer value attributed to hypokalemia was 1.64 (95% CI, 1.02 to 2.63; p = 0.040. The correlation remained statistically significant in patients free from antihypertensive drugs (r = −0.25; p = 0.018, but not in those taking angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics. Conclusions: The inverse correlation between values of potassium and D-dimer in patients with AAF provides important and complementary information about the thromboembolic risk of these patients.

  10. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation

    D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF). To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98) had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004). The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029). An inverse and highly significant correlation was found between serum potassium and D-dimer (r = −0.21; p < 0.001), even after adjustments for age and sex (beta coefficient −94.8; p = 0.001). The relative risk for a positive D-dimer value attributed to hypokalemia was 1.64 (95% CI, 1.02 to 2.63; p = 0.040). The correlation remained statistically significant in patients free from antihypertensive drugs (r = −0.25; p = 0.018), but not in those taking angiotensin-receptor blockers, angiotensin-converting enzyme inhibitors, or diuretics. The inverse correlation between values of potassium and D-dimer in patients with AAF provides important and complementary information about the thromboembolic risk of these patients

  11. Defining obesity cut-off points for migrant South Asians.

    Laura J Gray

    Full Text Available BACKGROUND: Body mass index (BMI and waist circumference (WC are used to define cardiovascular and type 2 diabetes risk. We aimed to derive appropriate BMI and WC obesity cut-off points in a migrant South Asian population. METHODS: 4688 White Europeans and 1333 South Asians resident in the UK aged 40-75 years inclusive were screened for type 2 diabetes. Principal components analysis was used to derive a glycaemia, lipid, and a blood pressure factor. Regression models for each factor, adjusted for age and stratified by sex, were used to identify BMI and WC cut-off points in South Asians that correspond to those defined for White Europeans. FINDINGS: For South Asian males, derived BMI obesity cut-off points equivalent to 30.0 kg/m(2 in White Europeans were 22.6 kg/m(2 (95% Confidence Interval (95% CI 20.7 kg/m(2 to 24.5 kg/m(2 for the glycaemia factor, 26.0 kg/m(2 (95% CI 24.7 kg/m(2 to 27.3 kg/m(2 for the lipid factor, and 28.4 kg/m(2 (95% CI 26.5 kg/m(2 to 30.4 kg/m(2 for the blood pressure factor. For WC, derived cut-off points for South Asian males equivalent to 102 cm in White Europeans were 83.8 cm (95% CI 79.3 cm to 88.2 cm for the glycaemia factor, 91.4 cm (95% CI 86.9 cm to 95.8 cm for the lipid factor, and 99.3 cm (95% CI 93.3 cm to 105.2 cm for the blood pressure factor. Lower ethnicity cut-off points were seen for females for both BMI and WC. CONCLUSIONS: Substantially lower obesity cut-off points are needed in South Asians to detect an equivalent level of dysglycemia and dyslipidemia as observed in White Europeans. South Asian ethnicity could be considered as a similar level of risk as obesity (in White Europeans for the development of type 2 diabetes.

  12. Analytical and clinical performance of a new point of care LABGEOIB D-dimer test for diagnosis of venous thromboembolism.

    Song, Jaewoo; Kweon, Tae Dong; Song, Yeajin; Lee, Eun Young; Kim, Sue Jung; Park, Rojin

    2014-01-01

    LABGEO(IB) D-dimer Test is a newly developed POC D-dimer assay and the first commercially available POC immunoassay instrument that exploits the disk rotation method for extraction of plasma. Citrate plasma was obtained from 201 apparently healthy subjects and 91 patients suspected for VTE, and their D-dimer level was measured by the LABGEO(IB) D-Dimer Test (LABGEO D-dimer) and HemosIL D-dimer test as a comparative method. To examine the effect of blood cells and anticoagulant, paired blood samples anticoagulated by heparin and citrate were obtained from various postoperative patients. The overall diagnostic performance of LABGEO(IB) D-dimer and HemosIL was comparable with similar area under ROC curve (p=0.79). The cut-off levels recommended by manufacturers (LABGEO D-dimer: 0.45 μg/ml fibrinogen equivalent unit (FEU), HemosIL: 0.23 μg/ml D-dimer unit (DDU)) and those yielding highest diagnostic efficiency (LABGEO D-dimer: 1.41 μg/ml FEU; HemosIL: 0.85 μg/ml DDU), were chosen for the evaluation. For LABGEO D-dimer negative predictive value (NPV), positive predictive value (PPV), sensitivity, specificity, and negative likelihood ratio (LR-neg) were 93-100%, 67-89%, 93-100%, 53-89% and 0.00-0.08. For HemosIL D-dimer, NPV, PPV, sensitivity, specificity and LR-neg were 90 - 100%, 76-95%, 89-100%, 70-96% and 0.00-0.12, all comparable to results for LABGEO D-dimer. LABGEO D-dimer test demonstrated acceptable performance when used for the VTE diagnostic work-up. PMID:25117092

  13. High Pretreatment D-Dimer Levels Correlate with Adverse Clinical Features and Predict Poor Survival in Patients with Natural Killer/T-Cell Lymphoma

    Bi, Xi-wen; Wang, Liang; Zhang, Wen-Wen; Sun, Peng; Yan, Shu-Mei; Liu, Pan-pan; Li, Zhi-Ming; Jiang, Wen-qi

    2016-01-01

    Pretreatment plasma D-dimer levels have been reported to predict survival in several types of malignancies. The aim of this study was to evaluate the prognostic value of D-dimer levels in patients with newly diagnosed natural killer/T-cell lymphoma (NKTCL). The cut-off value of D-dimer to predict survival was set as 1.2 μg/mL based on the receiver operating curve analysis. Patients with a D-dimer level ≥ 1.2 μg/mL had significantly more adverse clinical features, including poor performance st...

  14. Fiber optic D dimer biosensor

    Glass, Robert S.; Grant, Sheila A.

    1999-01-01

    A fiber optic sensor for D dimer (a fibrinolytic product) can be used in vivo (e.g., in catheter-based procedures) for the diagnosis and treatment of stroke-related conditions in humans. Stroke is the third leading cause of death in the United States. It has been estimated that strokes and stroke-related disorders cost Americans between $15-30 billion annually. Relatively recently, new medical procedures have been developed for the treatment of stroke. These endovascular procedures rely upon the use of microcatheters. These procedures could be facilitated with this sensor for D dimer integrated with a microcatheter for the diagnosis of clot type, and as an indicator of the effectiveness, or end-point of thrombolytic therapy.

  15. Plasma D-dimer levels are associated with stroke subtypes and infarction volume in patients with acute ischemic stroke.

    Wen-Jie Zi

    Full Text Available BACKGROUND: It has been suggested that modestly elevated circulating D-dimer values may be associated with acute ischemic stroke (AIS. Thus, the purpose of this study was to investigate the association between plasma D-dimer level at admission and AIS in Chinese population. METHODS: In a prospective observational study, plasma D-dimer levels were measured using a particle-enhanced, immunoturbidimetric assay on admission in 240 Chinese patients with AIS. The National Institutes of Health Stroke Scale (NIHSS score was assessed on admission blinded to D-dimer levels. RESULTS: Plasma median D-dimer levels were significantly (P = 0.000 higher in AIS patients as compared to healthy controls (0.88; interquartiler range [IQR], 0.28-2.11 mg/L and 0.31; IQR, 0.17-0.74 mg/L. D-dimer levels increased with increasing severity of stroke as defined by the NIHSS score(r = 0.179, p = 0.005 and infarct volume(r = 0.425, p = 0.000. Those positive trends still existed even after correcting for possible confounding factors (P = 0.012, 0.000; respectively. Based on the Receiver operating characteristic (ROC curve, the optimal cut-off value of plasma D-dimer levels as an indicator for diagnosis of cardioembolic strokes was projected to be 0.91 mg/L, which yielded a sensitivity of 83.7% and a specificity of 81.5%, the area under the curve was 0.862(95% confidence interval [CI], 0.811-0.912. CONCLUSION: We had shown that plasma D-dimer levels increased with increasing severity of stroke as defined by the NIHSS score and infarct volume. These associations were independent other possible variables. In addition, cardioembolic strokes can be distinguished from other stroke etiologies by measuring plasma D-dimer levels very early (0-48 hours from stroke symptom onset.

  16. Evaluation of performance including influence by interfering substances of the Innovance D-dimer assay on the Sysmex coagulation analyzer.

    Park, Seo-Jin; Chi, Hyun-Sook; Chun, Soh Hyun; Jang, Seongsoo; Park, Chan-Jeoung

    2011-01-01

    D-dimer is formed during activation of the coagulation system and is commonly assayed in order to diagnose disseminated intravascular coagulation, deep vein thrombosis, and pulmonary embolism. Enzyme-linked immunosorbent assay has been validated as the reference method, but it is a time-consuming procedure. The objective of this study was to evaluate a new immunoturbidimetric, particle-enhanced, Innovance(®) D-dimer immunoassay. A total of 129 plasma samples from apparently healthy individuals and 298 samples from patients were collected for linearity, precision, and correlation studies. Testing the precision of low- and high-controls yielded CV values of 2.08% and 1.76%, respectively. The central 95% non-parametric reference interval estimated from healthy controls was 0.093-0.68 mg/L Fibrinogen Equivalent Units (FEU; median, 0.26 mg/L FEU). Comparison analysis yielded acceptable correlation with the STA Liatest(®) D-dimer assay (R(2) = 0.9471). At a cut-off level of FEU, the sensitivity and specificity indices of the Innovance D-dimer assay were 99.7% and 89.1%, respectively. Thus the Innovance D-dimer method showed acceptable precision and linearity, and the assay results showed acceptable correlation with the STA Liatest D-dimer method. The Innovance method was relatively unaffected by potential interfering substances such as bilirubin and hemoglobin. In conclusion, the Innovance D-dimer assay is suitable for monitoring D-dimer concentrations in various clinical conditions and should be useful in clinical laboratories. PMID:21325250

  17. The relationship between D-dimer level and the development of atrial fibrillation in patients with systolic heart failure.

    Zorlu, Ali; Akkaya, Emre; Altay, Hakan; Bektasoglu, Gokhan; Turkdogan, Kenan Ahmet; Sincer, Isa; Vuruskan, Ertan; Cınar, Ziynet; Tandogan, Izzet; Yilmaz, Mehmet Birhan

    2012-05-01

    Heart failure (HF) is one of the most common and leading cause of death worldwide. Clinical trials provide evidence that the development of atrial fibrillation (AF) is a marker of poor prognosis in patients with HF. Furthermore, elevated D-dimer level is associated with increased cardiovascular mortality independent of AF in HF patients. We investigated whether plasma D-dimer levels in patients with hospitalized systolic HF could predict development of AF. A total of 150 consecutive patients with sinus rhythm who admitted to the emergency department with hospitalized systolic HF were evaluated. All hospitalized patients were obtained D-dimer levels within the first 24 h following admission. Atrial fibrillation developed in 31 (20.7%) patients during follow-up period of 6.3 ± 5 months. Patients who developed atrial fibrillation had significantly increased levels of D-dimer [608 (339-1,022) ng/ml versus 1,100 (608-2,599) ng/ml, P = 0.001]. Optimal cut-off level of D-dimer to predict development of AF was found to be >792 ng/ml. D-dimer >792 ng/ml, right ventricular dilatation, age, systolic pulmonary pressure, left atrium size, moderate to severe tricuspid regurgitation, and beta blocker usage were found to have prognostic significance in univariate analysis. In multivariate Cox proportional-hazards model, D-dimer levels >792 ng/ml (HR = 3.019, P = 0.006), and right ventricular dilatation (HR = 8.676, P = 0.003) were associated with an increased risk of new-onset AF. In conclusion, D-dimer could predict development of AF in patients with hospitalized systolic HF. PMID:22139027

  18. Designing the sound of a cut-off drum

    Martinetti, Pierre

    2015-01-01

    The spectral action in noncommutative geometry naturally implements an ultraviolet cut-off, by counting the eigenvalues of a (generalized) Dirac operator lower than an energy of unification. Inverting the well known question "how to hear the shape of a drum ?", we ask what drum can be designed by hearing the truncated music of the spectral action ? This makes sense because the same Dirac operator also determines the metric, via Connes distance. The latter thus offers an original way to implement the high-momentum cut-off of the spectral action as a short distance cut-off on space. This is a non-technical presentation of the results of http://arxiv.org/abs/1305.2605

  19. On cosmic-ray cut-off terminology

    The study of cosmic-ray access to location within the geomagnetic field has evolved over the past fifty years. Cosmic-ray cut-off terminology, originally developed to describe particle access and cut-off rigidities, has not evolved with the scientific advances in the field, and misunderstandings and misapplications of historical work have occurred. This paper is an attempt to remedy this situation by clarifying the areas in which changes have occurred and by providing a cross reference between the historical terms and those terms now in use for innovative cosmic-ray studies which are underway in several laboratories

  20. Cut-off wall construction at the Peribonka hydroelectric project

    Ouellette, C.; Morency, J.Y.; Bigras, A.; Hammamji, Y. [Hydro-Quebec Equipment, Montreal, PQ (Canada); Gagne, B. [SNC-Lavalin, Montreal, PQ (Canada); Rattue, A. [SNC-Lavalin, Montreal, PQ (Canada). Energy Division

    2007-07-01

    The Peribonka hydroelectric development, located in Quebec includes a 80 metre high dam and two dikes consisting of zoned earth and rock fills with a till core, an underground power house, a diversion tunnel and a spillway. The project is in its final stages of construction and presented several challenges related to the presence of a deep canyon under the river bed filled with alluvial sand, gravel, cobbles and boulders. The design included an approximately 10 metre high working platform in the river and the construction of a plastic concrete cut-off wall down to bedrock. The construction of a 116 metre deep single cut-off wall that is at the limit of precedent in terms of present knowledge and equipment capacity was the main challenge for the project. In addition, a 52 metre deep plastic concrete cut-off wall was built under a dyke. This conference discussed the cut-off wall construction experience, as well as the challenges encountered and how they were addressed. The paper presented a description of the site conditions and the scope of the work, as well as the typical specifications of the cut-offs. The paper also provided an overview of an extensive quality control program that was implemented for all phases of the project construction and results of the project. Last, the paper described the challenges, problems encountered and the modifications from the initial design and specifications. It was concluded that the topography at the Peribonka dam site showed a deep narrow gully filled with alluvial material comprising sand, gravel, cobbles and boulders. Elaborate quality control was essential to ensure that excavation and concreting were done to satisfactory standards. 4 refs., 4 tabs., 11 figs.

  1. The diagnostic value of ventilation-perfusion scintigraphy combined with plasma D-dimer assay in diagnosis of pulmonary embolism

    Objective: To investigate the clinical diagnostic value of ventilation-perfusion scintigraphy combined with plasma D-dimer assay in diagnosis of pulmonary embolism (PE). Methods: One hundred and four patients with clinically suspected PE underwent both pulmonary ventilation-perfusion scintigraphy and plasma D-dimer assay. According to the criteria of prospective investigation of the pulmonary embolism diagnosis (PIOPED), ventilation-perfusion scintigraphy was interpreted as normal, very low or low probability of PE, intermediate probability of PE and high probability of PE. High probability was considered as positive; normal and very low or low probability as negative and intermediate probability as non-diagnostic. Plasma D-dimer levels were measured using a quantitative immunoturbidimetric method, and a cut-off value of 500 mg/L was used in the diagnosis of PE. Clinical diagnostic value of ventilation-perfusion scintigraphy, D-dimer assay and combined use of ventilation-perfusion scintigraphy and D-dimer assay for diagnosing PE was evaluated, respectively, comparing with the final clinical diagnosis that was based on the clinical findings. Results: Among the 104 patients, 44 were diagnosed with PE and 60 were excluded. Ventilation-perfusion scintigraphy provided diagnostic interpretations for 86 (82.7%) patients, and non-diagnostic interpretations for 18 (17.3%) patients. For diagnosing PE, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of ventilation-perfusion scintigraphy was 84.1%, 75.0%, 78.8%, 71.2% and 86.5%, respectively, and with D-dimer assay was 93.2%, 60.0%, 74.0%, 63.1% and 92.3%, respectively. If a plasma D-dimer level of < 500 mg/L was taken as a criterion to exclude PE for those intermediate probability of ventilation-perfusion scintigraphy, the diagnostic specificity and accuracy would be raised to 85.0% and 84.6%, respectively. Conclusions: When a non-diagnostic interpretation was occurred on

  2. A PROBLEM OF CUTTING OFF THE LAMINATED SEMIS TYPE PLATE

    Florin Ciofu

    2012-11-01

    Full Text Available A problem often coped on many domains such as wood manufacturing, glass, plastics and metallic platework industry, is the shaping or cutting off a big plate in many pieces. With this purpose there are algorithms of optimizing for positioning the parts following to be cut off from a row plate. From mathematical point of view, in positioning the parts on a raw plate the number of solutions increase four times evrey time a new part is added, and in case of finding the best solution for about few hundreds of pieces or parts would require years of processing on the most performant computers nowadays – for an analogy remember the famous story with the rice beads which the King had to pay to the master teaching him the chess: twice more for each square of the chessboard; for the total quantity assessment, King ascertained that the crops in his whole life wouldn’t have been enough.

  3. Overcoming cut-off restrictions in multimorbidity prevalence estimates

    Holzer, Barbara M.; Siebenhuener, Klarissa; Bopp, Matthias; Minder, Christoph E

    2014-01-01

    Background Presently, there is no consensus on how to define multimorbidity. In this paper we investigate the connection between prevalence estimates for two or more and three or more chronic conditions to improve comparability of multimorbidity studies with different cut-offs. Methods In a systematic review of the literature published between January, 1990 and December, 2011, we found 52 suitable studies, many providing prevalence estimates for several age groups. A total of 31 studies repor...

  4. Hemoglobin cut-off values in healthy Turkish infants

    Ahmet Arvas; Emel Gür; DurmuşDoğan

    2014-01-01

    Background: Anemia is a widespread public health problem associated with an increased risk of morbidity and mortality. This study was undertaken to determine the cut-off value of hemoglobin for infant anemia. Methods: A cross-sectional retrospective study was carried out at well-baby clinics of a tertiary care hospital. A total of 1484 healthy infants aged between 4 to 24 months were included in the study. The relationship of hemoglobin (Hb) levels with mother age, birth weight, weight gain rate, feeding, and gender was evaluated. Results: The Hb levels were assessed in four age groups (4 months, 6 months, 9-12 months, and 15-24 months) and the cut-off values of Hb were determined. Hb cut-off values (5th percentile for age) were detected as 97 g/L and 93 g/L at 4 months and 6 months, respectively. In older infants, the 5th percentile was 90.5 g/L and 93.4 g/L at 9-12 months and 15-24 months, respectively. The two values were lower than the World Health Organization criteria for anemia, which could partly due to the lack of information on iron status in our population. However, this difference highlights the need for further studies on normal Hb levels in healthy infants in developing countries. Hb levels of females were higher in all age groups; however, a statistically significant difference was found in gender in only 6 month-old infants. No statistically significant difference was found among Hb levels, mother's age, birth weight, weight gain rate, and nutritional status. Conclusion: Hb cut-off values in infants should be re-evaluated and be compatible with growth and development of children in that community.

  5. Resonance and cut-off surfaces in the ion cyclotron frequency range in toroidal geometry

    Resonances and cut-offs of the fast Alfven and ion-cyclotron waves have been studied for a multicomponent plasma in a toroidal axisymmetric geometry. The resonance and cut-off frequencies are given by eigenvalues of ordinary differential equations on the rosonance and cut-off sufaces, respectively. These surfaces coincide with magnetic surfaces. (author)

  6. Impact of d-Dimers on the Differential Diagnosis of Acute Chest Pain: Current Aspects Besides the Widely Known.

    Hahne, Kathrin; Lebiedz, Pia; Breuckmann, Frank

    2014-01-01

    d-dimers are cleavage products of fibrin that occur during plasmin-mediated fibrinolysis of blood clots. In the emergency department, d-dimer measurement represents a valuable and cost-effective tool in the differential diagnosis of acute chest pain including the main life-threatening entities: acute coronary syndrome, pulmonary embolism, and acute aortic syndrome. Whereas the diagnostic and prognostic values of d-dimer testing in acute coronary syndrome is of less priority, increases of d-dimers are frequently found in venous thromboembolism and acute aortic syndromes, especially acute aortic dissection. As to the high negative predictive value of d-dimer in those disorders, patients with low to intermediate pretest probability may profit in terms of less necessity of further non-invasive or even invasive imaging, simultaneously reducing potential complications and healthcare-related costs. However, because of the low specificity of the different d-dimer tests in contrast to its frequent usage, adequate interpretation is required. Age-related adjustment of d-dimer levels may be used to increase its diagnostic power. PMID:25392700

  7. D-Dimer predicts prognosis and non-resectability in patients with pancreatic cancer: a prospective cohort study.

    Stender, Mogens T; Larsen, Anders C; Sall, Mogens; Thorlacius-Ussing, Ole

    2016-07-01

    To examine the impact of plasma D-dimer levels in predicting 3-year survival and nonresectability in pancreatic cancer patients. Ninety-five patients were divided into three groups according to plasma D-dimer levels. Kaplan-Meier survival curves and hazard ratios were computed, and diagnostic indices of D-dimer in the prediction of resectability were assessed. The median survival among patients with low, medium and high D-dimer levels was 13.7 [95% confidence interval (CI): 10.2-19.6], 6.2 (95% CI: 2.0-15.1) and 2.4 months (95% CI: 1.4-3.3), respectively. The adjusted hazard ratio of death in the group of patients with high D-dimer levels was 2.2 (95% CI: 1.1-4.2). The positive and negative predictive values of D-dimer in the prediction of nonresectability were 89% (95% CI: 77-96%) and 48% (95% CI: 33- 63%), respectively. An elevated D-dimer level is associated with reduced survival in pancreatic cancer and predicts nonresectability. PMID:27182687

  8. Reconfigurable pyramidal antenna loaded by a cut-off waveguide-application to ARNS/RNSS services

    Hebib, Sami; Aubert, Hervé; Pascal, Olivier; Fonseca, Nelson; Ries, Lionel; Lopez, Jean-Marc

    2009-01-01

    International audience A novel reconfigurable and circularly polarized antenna topology for satellite application services, based on a pyramidal geometry, is proposed. Frequency agility is simply obtained by loading the radiating elements by Radio-Frequency switches. The ground plane of the antenna is perforated and loaded by a cut-off and open-ended waveguide. The length of this waveguide is adjusted to achieve a good trade-off between rear radiation and impedance matching. A specific app...

  9. The Value of D-Dimer in Diagnosis of Acute Mesenteric Ischemia and Differential Diagnosis from Acute Pancreatitis and Acute Cholecystitis

    Semih Hot

    2016-03-01

    Full Text Available Objective: Because of its poor prognosis and high mor­tality rate, early diagnosis of acute mesenteric ischemia (AMI is a challenge. The value of serum markers in the diagnosis of AMI is limited and the studies related with the D-dimer test carried out in recent years. In this prospec­tive study we investigated the value of the level of plasma D-dimer in the diagnosis of AMI and the differential diag­nosis from acute pancreatitis and acute cholecystitis. Methods: We included 89 patients who admitted to our emergency department with abdominal pain. The number and the diagnosis of the patients were 17 AMI, 42 acute pancreatitis and 30 acute cholecystitis, respectively. We measured the levels of plasma D-dimer of all patients by using a latex agglutination ‘immunoassay’ method. Even­tually we calculated the sensitivity and specificity of D-dimer test in the diagnosis of AMI. Results: We determined the specificity of the D-dimer test in the differential diagnosis of AMI as 50% from acute pancreatitis, 70% from acute cholecystitis, 58.3% from all the control group and the sensitivity was 100%. Conclusion: The measurement of plasma D-dimer con­centration may be useful in the differential diagnosis of AMI from acute pancreatitis and acute cholecystitis. How­ever, to reveal the diagnostic value of D-dimer test more clearly, further studies with larger series are needed, where cut-off value is highly defined, and other patients with acute abdominal pain are added into the control group.

  10. Effective Potential in Curved Space and Cut-Off Regularizations

    Sobreira, Flavia; Shapiro, Ilya L

    2011-01-01

    We consider derivation of the effective potential for a scalar field in curved space-time within the physical regularization scheme, using two sorts of covariant cut-off regularizations. The first one is based on the local momentum representation and Riemann normal coordinates and the second is operatorial regularization, based on the Fock-Schwinger-DeWitt proper-time representation. We show, on the example of a self-interacting scalar field, that these two methods produce equal results for divergences, but the first one gives more detailed information about the finite part. Furthermore, we calculate the contribution from a massive fermion loop and discuss renormalization group equations and their interpretation for the multi-mass theories.

  11. Negative effective mass below a cut-off frequency

    Yao, Shanshan; Hu, Gengkai

    2010-01-01

    Acoustic metamaterials with negative effective mass below a cut-off frequency are studied. An equivalent mass-spring structure is firstly proposed for such metamaterials, the effective mass is found to follow the Drude model: being negative below a specific frequency. The peculiar behavior is then verified by transmission experiments operating in the low-frequency regime. Inspired by the mass-spring model, we investigate the two-dimensional elastic waveguide with clamped boundaries and attribute the bandgap occurring below a critical frequency to negative effective mass density. The finding helps us to design a new acoustic Drude metamaterial, which enables shearing and bending deformations, in contrast to the membrane-type ones. Both simulation and experimental results show that the proposed metamaterial exhibits negative effective mass below 1200 Hz, thus opening broadband applications in vibration and noise controls.

  12. Physical and cut-off effects of heavy sea quarks

    Knechtli, Francesco; Bruno, Mattia; Finkenrath, Jacob; Leder, Björn; Marinkovic, Marina; Sommer, Rainer

    2014-01-01

    We simulate a theory with two dynamical O($a$) improved Wilson quarks whose mass $M$ ranges from a factor eight up to a factor two below the charm quark mass and at three values of the lattice spacing ranging from 0.066 to 0.034 fm. This theory is a prototype to study the decoupling of heavy quarks. We measure the mass and cut-off dependence of ratios of gluonic observables defined from the Wilson flow or the static potential. The size of the 1/$M$ corrections can be determined and disentangled from the lattice artifacts. The difference with the pure gauge theory is at the percent level when two quarks with a mass of the charm quark are present.

  13. Emission Enhancement in a Plasmonic Waveguide at Cut-Off

    Andrea Alù

    2011-01-01

    Full Text Available Enhancement of molecular emission is usually obtained by coupling small optical emitters with external resonant structures and systems, as first established by Purcell several decades ago, and verified in several recent investigations using molecules or quantum dots coupled with plasmonic nanoantennas. Here we theoretically investigate in detail a different mechanism for emission enhancement, based on our recent idea of a plasmonic nanolauncher [Phys. Rev. Lett. 2009, 103, 043902], i.e., a metamaterial-inspired ultranarrow waveguide channel operating near its cut-off frequency. Such system is not necessarily at resonance, but its peculiar operation may provide enhanced emission over a relatively broad physical area, which may allow enhancement of emission independent of the position of an individual or of a group of molecules along such plasmonic channel, and the possibility to bend and route the emitted energy with large flexibility. We present here extensive theoretical and numerical results that confirm this intuition and may envision a novel method for molecular emission enhancement at the nanoscale, with more flexibility than the conventional Purcell resonance techniques.

  14. Singularity of macroscopic variables near boundary for gases with cut-off inverse-power potential

    Chen, I-Kun; Hsia, Chun-Hsiung

    2014-01-01

    In this article, the boundary singularity for stationary solutions of the linearized Boltzmann equation with cut-off inverse power potential is analyzed. In particular, for cut-off hard-potential cases, we establish the asymptotic approximation for the gradient of the moments. Our analysis indicates the logarithmic singularity of the gradient of the moments.

  15. Cut-off frequency of magnetostrictive materials based on permeability spectra

    Meng Hao; Zhang Tianli [Key Laboratory of Aerospace Materials and Performance (Ministry of Education), School of Materials Science and Engineering, Beihang University, Beijing 100191 (China); Jiang Chengbao, E-mail: jiangcb@buaa.edu.cn [Key Laboratory of Aerospace Materials and Performance (Ministry of Education), School of Materials Science and Engineering, Beihang University, Beijing 100191 (China)

    2012-06-15

    The loss behavior and cut-off frequency of TbDyFe alloy and TbDyFe/epoxy composite have been investigated by measuring their permeability spectra. The loss factor of TbDyFe alloy increases exponentially as the frequency goes up, while it is almost unchanged for the TbDyFe/epoxy composite. The loss factor value for the TbDyFe composite is only 4.3% of that for the monolithic TbDyFe alloy at high frequency of 10 kHz under the peak magnetic induction of 10 mT. The cut-off frequency of TbDyFe/epoxy composite is 6800 kHz, 3 orders of magnitude larger than that of TbDyFe alloy. The cut-off frequency is found to be the ferromagnetic resonance frequency and can be calculated from Snoek's law. - Highlights: Black-Right-Pointing-Pointer The cut-off frequency of TbDyFe alloy and TbDyFe/epoxy composite has been investigated. Black-Right-Pointing-Pointer Permeability spectra are used to study loss behavior and cut-off frequency. Black-Right-Pointing-Pointer A mathematic formula is deduced to predict the cut-off frequency. Black-Right-Pointing-Pointer TbDyFe/epoxy composite presents high cut-off frequency of 6800 kHz.

  16. Transmission characteristics of the wave cut-off probe with parallel plates

    Kang, Hyun-Ju; Kim, Yu-Sin; Chung, Chin-Wook

    2012-10-01

    A cut-off probe has been used to obtain an absolute electron density from a plasma frequency. A cut-off probe with parallel plates was constructed to investigate the transmission characteristics of electromagnetic waves and electrostatic waves at various gaps, pressures and powers. It is found that a clear cut-off peak at a plasma frequency and many other peaks due to plasma sheath series resonance, cavity resonance and transmission line are observed. By using circuit model of plasma and transmission line theory, the various peaks was analyzed and discussed.

  17. Serum Potassium Levels Inversely Correlate with D-Dimer In Patients with Acute-Onset Atrial Fibrillation.

    Cervellin, Gianfranco; Bonfanti, Laura; Picanza, Alessandra; Lippi, Giuseppe

    2014-12-01

    Background: D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared to subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. Objective: D-dimer values are frequently increased in patients with atrial fibrillation (AF) compared with subjects in sinus rhythm. Hypokalemia plays a role in several cardiovascular diseases, but little is known about the association with AF. The aim of this study was to investigate correlations between D-dimer and serum potassium in acute-onset AF (AAF). Methods: To investigate the potential correlation between the values of serum potassium and D-dimer in patients with AAF, we retrospectively reviewed clinical and laboratory data of all emergency department visits for AAF in 2013. Results: Among 271 consecutive AAF patients with D-dimer assessments, those with hypokalemia (n = 98) had significantly higher D-dimer values than normokalemic patients (139 versus 114 ng/mL, p = 0.004). The rate of patients with D-dimer values exceeding the diagnostic cut-off was higher in the group of patients with hypokalemia than in those with normal serum potassium (26.5% versus 16.2%; p = 0.029). An inverse and highly significant correlation was found between serum potassium and D-dimer (r = -0.21; p investigar a correlação entre os níveis séricos de D-dímero e potássio na FA aguda (FAA). Métodos: Para investigar a existência de uma potencial correlação entre os níveis séricos de potássio e D-dímero em pacientes com FAA, realizamos uma revisão retrospectiva de dados clínicos e laboratoriais relacionados a todas as visitas ao departamento de emergência devido à FAA, no ano de 2013. Resultados: Entre os 271 pacientes com FAA, aqueles com hipopotassemia (n = 98) mostraram aumento significativo nos níveis de D-dímero, quando comparados com pacientes com concentrações normais de potássio (139 versus 114 ng/mL, p = 0

  18. Human papillomavirus testing in primary cervical screening and the cut-off level for hybrid capture 2 tests

    Rebolj, Matejka; Bonde, Jesper; Njor, Sisse Helle; Lynge, Elsebeth

    2011-01-01

    To determine the trade-off between the sensitivity and the specificity for high grade cervical intraepithelial neoplasia at hybrid capture 2 cut-off values above the standard = 1 relative light units/cut-off level (rlu/co).......To determine the trade-off between the sensitivity and the specificity for high grade cervical intraepithelial neoplasia at hybrid capture 2 cut-off values above the standard = 1 relative light units/cut-off level (rlu/co)....

  19. Epidemiological cut-off values for Flavobacterium psychrophilum MIC data generated by a standard test protocol

    Smith, P.; Endris, R.; Kronvall, G.;

    2016-01-01

    Epidemiological cut-off values were developed for application to antibiotic susceptibility data for Flavobacterium psychrophilum generated by standard CLSI test protocols. The MIC values for ten antibiotic agents against Flavobacterium psychrophilum were determined in two laboratories. For five...

  20. Spin cut-off factor in SPA and SPA + RPA approach

    Spin cut-off factor (σ) is an important parameter needed in Bethe's formula for the fixed-J level density. The parameter σ is also required to relate the theoretical calculated state density with the experimentally observed level density

  1. Surface effect theory in binary alloys: surfaces with cut-off

    A surface effect theory in binary alloys which ore ordered with surfaces with cut-off is presented. This theory is based in a model of pair interaction between first neighbours and includes long and short range effects. The (120) surface with sup(-) (110) monoatomic cut-off and terrace in the (110) planes of an alloy with body centered cubic structure is presented as example. Results for the concentrations in all the different surface sites are given. (L.C.)

  2. Phase properties of the cut-off high-order harmonics

    Khokhlova, M A

    2015-01-01

    The cut-off regime of high-order harmonic generation (HHG) by atoms in an intense laser field is studied numerically and analytically. We find that the cut-off regime is characterized by equal dephasing between the successive harmonics. The change of the harmonic phase-locking when HHG evolves from the cut-off to the plateau regime determines the optimal bandwidth of the spectral region which should be used for attosecond pulse generation via amplitude gating technique. The cut-off regime is also characterized by a linear dependence of the harmonic phase on the fundamental intensity. The proportionality coefficient grows as the cube of the fundamental wavelength, thus this dependence becomes very important for the HHG by mid-infrared fields. Moreover, for every high harmonic there is a {\\it range} of laser intensities providing the generation in the cut-off regime and the atomic response magnitude in this regime can be greater than that in the plateau regime. Thus the cut-off regime substantially contributes ...

  3. Preoperative plasma D-dimer is a predictor of one-year survival in colorectal cancer patients: a prospective clinical cohort study

    Stender, Mogens; Larsen, Torben Bjerregaard; Frøkjær, J.B.; Sørensen, Henrik Toft; Thorlacius-Ussing, Ole

    cancer and absence of preoperative deep venous thrombosis, we measured the preoperative plasma D-dimer levels and performed compression ultrasonography for deep venous thrombosis prior to surgery, as well as one week, one month, and one year after surgery. RESULTS: The cumulative incidence of deep venous......PURPOSE: The study examined if preoperative plasma D-dimer level was associated with the postoperative cumulative incidence of deep venous thrombosis in patients with colorectal cancer admitted for intended curative surgery. METHODS: In 176 consecutive patients with newly-diagnosed colorectal...... thrombosis up to one year after surgery was 20 percent (95 percent confidence interval, 12 to 31 percent) in the positive D-dimer group compared with 5 percent (95 percent confidence interval, 2 to 12 percent) in the negative D-dimer group. The adjusted hazard ratio of deep venous thrombosis in the positive...

  4. Calculating broad neutron resonances in a cut-off Woods-Saxon potential

    Baran, Á; Salamon, P; Vertse, T

    2015-01-01

    In a cut-off Woods-Saxon potential with realistic depth $S$-matrix poles being far from the imaginary wave number axis form a sequence where the distances of the consecutive resonances are inversely proportional with the cut-off radius value. Other poles lying closer to the imaginary wave number axis might have trajectories with irregular shapes as the depth of the potential increases. Poles being close repel each other, and their repulsion is responsible for the changes of the directions of the corresponding trajectories. The interaction is extremely sensitive to the cut-off radius value. The repulsion might cause that certain resonances become antibound and later resonances again when they collide on the imaginary axis.

  5. Calculating broad neutron resonances in a cut-off Woods-Saxon potential

    Baran, A.; Noszaly, Cs. [Faculty of Informatics, University of Debrecen, PO Box 12, Debrecen (Hungary); Salamon, P. [Hungarian Academy of Sciences (ATOMKI), Institute for Nuclear Research, PO Box 51, Debrecen (Hungary); Vertse, T. [Faculty of Informatics, University of Debrecen, PO Box 12, Debrecen (Hungary); Hungarian Academy of Sciences (ATOMKI), Institute for Nuclear Research, PO Box 51, Debrecen (Hungary)

    2015-07-15

    In a cut-off Woods-Saxon (CWS) potential with realistic depth S -matrix poles being far from the imaginary wave number axis form a sequence where the distances of the consecutive resonances are inversely proportional with the cut-off radius value, which is an unphysical parameter. Other poles lying closer to the imaginary wave number axis might have trajectories with irregular shapes as the depth of the potential increases. Poles being close repel each other, and their repulsion is responsible for the changes of the directions of the corresponding trajectories. The repulsion might cause that certain resonances become antibound and later resonances again when they collide on the imaginary axis. The interaction is extremely sensitive to the cut-off radius value, which is an apparent handicap of the CWS potential. (orig.)

  6. Investigation of the negative-mass behaviors occurring below a cut-off frequency

    Yao, Shanshan; Zhou, Xiaoming; Hu, Gengkai

    2010-10-01

    Negative-mass phenomena occurring below a cut-off frequency are examined using both theoretical and experimental methods. The paper begins with an investigation of a mass-spring structure, the effective mass of which is shown to be negative below a specific frequency. Due to the decaying nature of lattice waves in the negative-mass system, the transmission drop induced by negative effective mass is demonstrated experimentally. Further investigation is conducted for a rectangular solid waveguide with clamped boundary conditions. It is shown that the lowest bandgap mode of the clamped waveguide can be attributed to negative effective mass below a cut-off frequency. Based on this observation, elastic metamaterials made of a steel grid filled with styrene butadiene rubber are designed and fabricated. Both the simulation and experimental analyses demonstrate that the designed metamaterials have negative effective mass below a cut-off frequency.

  7. Cosmic ray cut-off rigidities as function of zenithal and azimuthal directions of arrival

    Dependences of cut-off rigidities for slantingly incident cosmic rays on the direction of their arrival into the Earth magnetic field caused by internal and external sources are investigated for Irkutsk station under the conditions of magnetosphere different geomagnetic activity. It is shown that with the increase of Kp index from 0 up to 4 the cut-off rigidities of slantingly incident cosmic rays decrease in succession, whereupon the effect of external sources (currents within the magnetopause, tail current and ring currents) results in different changes of geomagnetic thresholds for different directions of charged particle arrival. Thus, for example, cut-off-rigidities reduce by 6% for particles which arrive from southwest at 360 deg zenith angle, while for westparticles this difference constitutes only 0.6%

  8. Cut-off parameters in the one-dimensional two-fermion model

    It is shown that the usual cut-off procedure (α cut-off parameter) employed in the boson representation of the fermion field opepators of the one-djmensional two-fermion model (TFM) is an incorrect one as the computator of the hermitean-conjugate field operators at the same space-point fails to fulfil a certain relationship which was pointed out long ago by Jordan. The complete form of the boson representation (including the zero-mode) of a single fermion field and the correct values of the cut-off parameter α is reviewed following Jordan and generalized to the TFM. The cut-off parameter α corresponds to a bandwidth cut-off and Jordan's boson representation is exact only in the limit α → 0. The additional zero-mode terms make the exact solution of the backscattering and umklapp scattering problem to be valid only if a supplementary condition is imposed on the coupling constants. Using the present bosonization technique all the inconsistencies of the TFM are removed. The one-particle Green's function and response functions of the Tomonaga-Luttinger model (TLM) are calculated and found to be identical with those obtained by direct diagram summation. The energy gap appearing in the spectrum of the TFM with backscattering and umklapp scattering for certain values of the coupling constants is shown to be proportional to the momentum transfer cut-off γ-1 which has to be kept finite while α goes to zero. Under such conditions the anticommunication relations and Jordan's commutator are invariant under the canonical transformation on the boson operators that diagonalizes the Hamiltonian of the TLM. The charge-density response function of the TFM with backscattering is perturbationally calculated up to the first order. The cut-off α-1 applies in the same way to terms which differ only by their spin indices in the expression of this response function. The charge-density response function is also evaluated at low frequencies for the exactly soluble TFM with

  9. Localization of fluctuation measurement by wave scattering close to a cut off layer

    In tokamaks several fluctuation diagnostics are based on the scattering of an electromagnetic wave close to a cut off layer. For example measurement of density fluctuations (n) by reflectometry and magnetic fluctuations (B) by cross polarization scattering. For such a configuration the eikonal approximation does not remain valid to describe the pump wave although it is valid to describe n(r) and B(r). In this paper we shall consider a linear density profile. An unidimensional exact analysis has been performed. Spatial and spectral localization of scattering process close to the cut off layer is investigated and a modified Bragg rule is derived. (author) 6 refs., 2 figs

  10. Duality Bounds on the Cut-Off Rate with Applications to Ricean Fading

    Lapidoth, Amos; Miliou, Natalia

    2005-01-01

    We propose a technique to derive upper bounds on Gallager's cost-constrained random coding exponent function. Applying this technique to the non-coherent peak-power or average-power limited discrete time memoryless Ricean fading channel, we obtain the high signal-to-noise ratio (SNR) expansion of this channel's cut-off rate. At high SNR the gap between channel capacity and the cut-off rate approaches a finite limit. This limit is approximately 0.26 nats per channel-use for zero specular compo...

  11. Cut-off rate calculations for the outer channel in a concatenated cooling system

    Herro, M. A.; Costello, D. J., Jr.; Hu, L.

    1984-01-01

    Concatenated codes were long used as a practical means of achieving long block or constraint lengths for combating errors on very noisy channels. The inner and outer encoders are normally separated by an interleaver, so that decoded error bursts coming from the inner decoder are randomized before entering the outer decoder. The effectiveness of this interleaver is examined by calculating the cut-off rate of the outer channel seen by the outer decoder with and without interleaving. Interleaving never hurts the performance of a concatenated code, and when the inner code rate is near the cut-off rate of the inner channel, interleaving significantly improves code performance.

  12. Suppressing the weakly bound states in the photoassociation dynamics by using a frequency cut-off laser pulse

    The photoassociation dynamics of ultracold lithium atoms controlled by a cut-off pulse has been investigated theoretically by solving numerically the time-dependent Schrödinger equation using the mapped Fourier grid method. The frequency components of the laser pulse close to the atomic resonance are partly cut off. Compared with the typical Gauss-type pulses, the cut-off pulse is helpful to suppress efficiently the weakly bound states and prepare the associated molecules in the lower vibrational states. Especially, the dependence of photoassociation probability on the cut-off position of the laser pulse is explored. (atomic and molecular physics)

  13. Age- and sex-dependent reference intervals for D-dimer

    Haase, Christine; Joergensen, Maja; Ellervik, Christina; Joergensen, Mikala Klok; Bathum, Lise

    2013-01-01

    A low D-dimer is commonly used to exclude venous thromboembolism in low risk patients. However, the reference intervals are poorly defined and D-dimer has been shown to increase by patient age. We aimed to establish age- and sex-dependent D-dimer reference intervals and to test the consequence of...

  14. Establishing Streptomycin Epidemiological Cut-Off Values for Salmonella and Escherichia coli

    Migura, Lourdes Garcia; Sunde, Marianne; Karlsmose, Susanne;

    2011-01-01

    This study was conducted to elucidate the accuracy of the current streptomycin epidemiological cut-off value (ECOFF) for Escherichia coli and Salmonella spp. A total of 236 Salmonella enterica and 208 E. coli isolates exhibiting MICs between 4 and 32 mg/L were selected from 12 countries. Isolates...

  15. Poverty and cutting off the power: Evaluation of the social contract of the Electricite de France

    Measures put in place by the French Electric Utility, Electricite de France (EDF) to assist those in default of payment of their electricity bills are evaluated. When introduced in 1996, it was expected that the new measures would reduce the necessity of cutting off power to the poor by one third. Notwithstanding these expectations and some progress in reducing the rate of power cut-off, the number of instances where service was denied, has risen. The evaluation is based on the annual survey of poor clients of the EDF undertaken by the Polling Institute Lavialle. The annual survey concerns itself chiefly with the attitude towards the service and the quality of dialogue between the Utility and its clients. The analysis resulted in three conclusions: (1) EDF appears to make progress in dealing with the problem based on evidence of higher client satisfaction and lower rate of cutting off power; (2) there is evidence of important beneficial changes in the policies of local EDF centres; and (3) there is noticeable evidence of improved coordination with social services agencies and higher quality of information made available; both these factors should contribute to higher client satisfaction. In general, EDF is to be congratulated for their efforts to date, for commissioning the survey and for participating in the evaluation. Nevertheless, in France the instances of cutting off electricity to poor households is still a fact of life, despite the commitment and the new measures put in place by EDF. 21 refs., 7 tabs., 1 fig

  16. The INTEGRAL high energy cut-off distribution of Seyfert galaxies

    Malizia, Angela; Ubertini, Pietro; Bird, Antony; Bazzano, Angela; Stephen, John; Molina, Manuela; Bassani, Loredana

    We present the primary continuum parameters, the photon index and the high energy cut-off, of Seyfert galaxies extracted from the INTEGRAL complete sample of AGN. We performed a broad band (0.3-100 keV) spectral analysis by fitting simultaneously the soft and hard X-ray spectra obtained by XMM and INTEGRAL/IBIS-Swift/BAT respectively in order to investigate the general properties of these parameters in particular their distribution and mean values. We present the mean photon index for the t type 1 and type 2 objects of the whole sample as well as their mean high energy cut-off. This is the first time that the cut-off energy is constrained in a such large number of AGN. Using the main parameters of the primary continuum, we are able to obtain the actual physical parameters of the Comptonizing region i.e. the plasma temperature kTe the optical depth tau. Finally, with the high S/N spectra starting to come from NuSTAR it will soon be possible to better constrain the cut-off values in many AGN, allowing the determination of more physical models and so to better understand the continuum emission and geometry of the region surrounding black holes.

  17. The INTEGRAL high energy cut-off distribution of type 1 AGN

    Malizia, A; Bassani, L; Stephen, J B; Bazzano, A; Ubertini, P; Bird, A J

    2014-01-01

    In this letter we present the primary continuum parameters, the photon index Gamma and the high energy cut-off Ec, of 41 type-1 Seyfert galaxies extracted from the INTEGRAL complete sample of AGN. We performed a broad band (0.3-100 keV) spectral analysis by fitting simultaneously the soft and hard X-ray spectra obtained by XMM and INTEGRAL/IBIS-Swift/BAT respectively in order to investigate the general properties of these parameters in particular their distribution and mean values. We find a mean photon index for the whole sample of 1.73 with a standard deviation of 0.17 and a mean high energy cut-off of 128 keV with a standard deviation of 46 keV. This is the first time that the cut-off energy is constrained in a such large number of AGN. We have 26 measurements of the cut-off, which corresponds to 63% of the entire sample, distributed between 50 and 200 keV. There are a further 11 lower limits mostly below 300 keV. Using the main parameters of the primary continuum, we have been able to obtain the actual ph...

  18. Chronic kidney disease : Defining clinical cut-offs for albumin:creatinine ratio

    Bakker, Stephan J L

    2013-01-01

    Albuminuria is rapidly gaining recognition as a marker of the presence and of the progression of chronic kidney disease (CKD). In a new study, Naresh et al. attempt to define cut-off values for percentage change in urinary albumin:creatinine ratio that reflect changes in CKD status rather than rando

  19. The INTEGRAL High-energy Cut-off Distribution of Type 1 Active Galactic Nuclei

    Malizia, A.; Molina, M.; Bassani, L.; Stephen, J. B.; Bazzano, A.; Ubertini, P.; Bird, A. J.

    2014-02-01

    In this Letter we present the primary continuum parameters, the photon index Γ, and the high-energy cut-off E c of 41 type-1 Seyfert galaxies extracted from the International Gamma-Ray Astrophysics Laboratory (INTEGRAL) complete sample of active galactic nuclei (AGNs). We performed broadband (0.3-100 keV) spectral analysis by simultaneously fitting the soft and hard X-ray spectra obtained by XMM and INTEGRAL/IBIS-Swift/BAT, respectively, in order to investigate the general properties of these parameters, in particular their distribution and mean values. We find a mean photon index of 1.73 with a standard deviation of 0.17 and a mean high-energy cut-off of 128 keV with a standard deviation of 46 keV for the whole sample. This is the first time that the cut-off energy is constrained in such a large number of AGNs. We have 26 measurements of the cut-off, which corresponds to 63% of the entire sample, distributed between 50 and 200 keV. There are a further 11 lower limits mostly below 300 keV. Using the main parameters of the primary continuum, we have been able to obtain the actual physical parameters of the Comptonizing region, i.e., the plasma temperature kT e from 20 to 100 keV and the optical depth τ < 4. Finally, with the high signal-to-noise ratio spectra starting to come from NuSTAR it will soon be possible to better constrain the cut-off values in many AGNs, allowing the determination of more physical models and thus better understand the continuum emission and geometry of the region surrounding black holes.

  20. Raised BMI cut-off for overweight in Greenland Inuit – a review

    Stig Andersen

    2013-08-01

    Full Text Available Background. Obesity is associated with increased morbidity and premature death. Obesity rates have increased worldwide and the WHO recommends monitoring. A steep rise in body mass index (BMI, a measure of adiposity, was detected in Greenland from 1963 to 1998. Interestingly, the BMI starting point was in the overweight range. This is not conceivable in a disease-free, physically active, pre-western hunter population. Objective. This led us to reconsider the cut-off point for overweight among Inuit in Greenland. Design and findings. We found 3 different approaches to defining the cut-off point of high BMI in Inuit. First, the contribution to the height by the torso compared to the legs is relatively high. This causes relatively more kilograms per centimetre of height that increases the BMI by approximately 10% compared to Caucasian whites. Second, defining the cut-off by the upper 90-percentile of BMI from height and weight in healthy young Inuit surveyed in 1963 estimated the cut-off point to be around 10% higher compared to Caucasians. Third, if similar LDL-cholesterol and triglycerides are assumed for a certain BMI in Caucasians, the corresponding BMI in Inuit in both Greenland and Canada is around 10% higher. However, genetic admixture of Greenland Inuit and Caucasian Danes will influence this difference and hamper a clear distinction with time. Conclusion. Defining overweight according to the WHO cut-off of a BMI above 25 kg/m2 in Greenland Inuit may overestimate the number of individuals with elevated BMI.

  1. Cut-off period for slow magnetoacoustic waves in coronal plasma structures

    Afanasyev, A. N.; Nakariakov, V. M.

    2015-10-01

    Context. There is abundant observational evidence of longitudinal compressive waves in plasma structures of the solar corona, which are confidently interpreted in terms of slow magnetoacoustic waves. The uses of coronal slow waves in plasma diagnostics, as well as analysis of their possible contribution to coronal heating and the solar wind acceleration, require detailed theoretical modelling. Aims: We investigate the effects of obliqueness, magnetic field, and non-uniformity of the medium on the evolution of long-wavelength slow magnetoacoustic waves guided by field-aligned plasma non-uniformities, also called tube waves. Special attention is paid to the cut-off effect due to the gravity stratification of the coronal plasma. Methods: We study the behaviour of linear tube waves in a vertical untwisted straight field-aligned isothermal plasma cylinder. We apply the thin flux tube approximation, taking into account effects of stratification caused by gravity. The dispersion due to the finite radius of the flux tube is neglected. We analyse the behaviour of the cut-off period for an exponentially divergent magnetic flux tube filled in with a stratified plasma. The results obtained are compared with the known cases of the constant Alfven speed and the pure acoustic wave. Results: We derive the wave equation for tube waves and reduce it to the form of the Klein-Gordon equation with varying coefficients, which explicitly contains the cut-off frequency. The cut-off period is found to vary with height, decreasing significantly in the low-beta plasma and in the plasma with the beta of the order of unity. The depressions in the cut-off period profiles can affect the propagation of longitudinal waves along coronal plasma structures towards the higher corona and can form coronal resonators.

  2. Multiple Sclerosis Questionnaire for Job Difficulties (MSQ-Job): definition of the cut-off score.

    Schiavolin, Silvia; Giovannetti, Ambra Mara; Leonardi, Matilde; Brenna, Greta; Brambilla, Laura; Confalonieri, Paolo; Frangiamore, Rita; Mantegazza, Renato; Moscatelli, Marco; Clerici, Valentina Torri; Cortese, Francesca; Covelli, Venusia; Ponzio, Michela; Zaratin, Paola; Raggi, Alberto

    2016-05-01

    Multiple Sclerosis (MS) mainly affects people of working age. The Multiple Sclerosis Questionnaire for Job Difficulties (MSQ-Job) was designed to measure difficulties in work-related tasks. Our aim is to define cut-off score of MSQ-Job to identify potential critical situations that might require specific attention. A sample of patients with MS completed the MSQ-Job, WHODAS 2.0 and MSQOL-54 respectively for work difficulties, disability and health-related quality of life (HRQoL) evaluation. K-means Cluster Analysis was used to divide the sample in three groups on the basis of HRQoL and disability. ANOVA test was performed to compare the response pattern between these groups. The cut-off score was defined using the receiver operating characteristic (ROC) curve analyses for MSQ-Job total and count of MSQ-Job items scores ≥3: a score value corresponding to the maximum of the sensitivity-to-specificity ratio was chosen as the cut-off. Out of 180 patients enrolled, twenty were clustered in the higher severity group. The area under the ROC curve was 0.845 for the MSQ-Job total and 0.859 for the count of MSQ-Job items scores ≥3 while the cut-off score was 15.8 for MSQ-Job total and 8 for count of items scored ≥3. We recommend the use of MSQ-Job with this calculation as cut-off for identifying critical situations, e.g. in vocational rehabilitation services, where work-related difficulties have a significant impact in terms of lower quality of life and higher disability. PMID:26842465

  3. D-dimer testing for safe exclusion and risk stratification in patients with acute pulmonary embolism in primary care

    Zhou Yin

    2015-01-01

    Full Text Available Background: Safe exclusion and risk stratification are currently recommended for the initial management of patients with acute pulmonary embolism (APE. The aim of this study was to assess the safe exclusion and risk stratification value of D-dimer (DD for APE when tested at the beginning of admission. Materials and Methods: All consecutive Chinese APE patients and controls were recruited from January 2010 to December 2012. All measurements of serum indexes were made in duplicate and blinded to the patients′ status. All the 40 patients with the first episode of APE were confirmed by multi-detector computed tomographic pulmonary angiography. The plasma prothrombin time (PT, activated partial thromboplastin time, thrombin time, fibrinogen, and DD levels were measured within 24 h of admission. We used the Mann-Whitney U-test to determine the differences between groups and drew receiver operator characteristic curve to evaluate the indexes′ value in the APE screening. Results: The PT and DD in the APE group were significantly higher than those in the disease control group (P 1820 μg/L as cut-off value, the sensitivity, specificity, positive and negative predictive value was 82.5%, 75.2%, 56.9%, and 91.6%, respectively. Conclusion: The patients with APE showed significant higher DD levels compared with disease controls, suggesting a negative qualitative DD test result can safely and efficiently exclude APE in primary care.

  4. Determination of a saliva cotinine cut-off to distinguish pregnant smokers from pregnant non-smokers

    Hegaard, Hanne K; Kjaergaard, Hanne; Møller, Lars F; Wachmann, Carsten Henrik; Ottesen, Bent

    2007-01-01

    Objective validation of smoking status is necessary. Earlier studies have used saliva cotinine concentrations between 14.2 and 30 ng/ml as cut-off values to distinguish pregnant smokers from non-smokers. However, these cut-offs derive from studies including men and non-pregnant women. This...

  5. Mathematical model of processes in cut-off leaking steam generator as a part of operating ship reactor

    A mathematical model of processes in cut-off leaking steam generator of an operating ship reactor was presented. The model describes the coolant pressure increasing when filling the heat pipes system of cut-off leaking direct-flow steam generator, and allows estimating the time lag before putting restrictions on power maneuvering of the ship reactor

  6. Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy

    Grund, Birgit; Baker, Jason V; Deeks, Steven G;

    2016-01-01

    3 large cohorts. METHODS: In HIV-positive adults on suppressive ART, associations of IL-6, D-dimer, and hsCRP levels at study entry with serious non-AIDS conditions or death were studied using Cox regression. Hazard ratios (HR) adjusted for age, gender, study, and regression dilution bias (due to...

  7. Correlation analysis between plasma D-dimer levels and orthopedic trauma severity

    ZHANG Li-dan; LIU Hong-bo; LI Yu-neng; MA Hai-mei; LIU Ya-bo; WANG Man-yi

    2012-01-01

    Background The correlation between the plasma D-dimer level and deep vein thrombosis has not been conclusive in various studies.The aim of this research was to study the relationship between plasma D-dimer levels and the severity of orthopedic trauma by retrospective examination of orthopedic trauma cases.Methods Clinically acute trauma and non-acute trauma patients were selected and their plasma D-dimer levels were measured.Plasma D-dimer levels in patients of these two groups were compared.The relationship between the plasma D-dimer level and the severity of the trauma was also studied.Results There were 548 cases in the acute trauma group and 501 cases in the non-acute trauma group.The levels of plasma D-dimer were significantly higher in the acute trauma group than in the non-acute trauma group (P <0.01).In the acute trauma group,the correlation between the D-dimer level and the number of fractures was a positive linear correlation (r=0.9532).Conclusions Elevated plasma D-dimer is common in trauma patients.The D-dimer level and the number of fractures in the trauma patients are closely correlated.D-dimer is not only an indicator for the diagnosis of deep vein thrombosis and pulmonary embolus,but also an indicator of the severity of trauma in acute trauma patients.

  8. Fast beam cut-off method in RF-knockout extraction for spot-scanning

    Furukawa, T

    2002-01-01

    An irradiation method with magnetic scanning has been developed in order to provide accurate irradiation even for an irregular target shape. The scanning method has strongly required a lower ripple of the beam spill and a faster response to beam-on/off in slow extraction from a synchrotron ring. At HIMAC, RF-knockout extraction has utilized a bunched beam to reduce the beam-spill ripple. Therefore, particles near the resonance can be spilled out from the separatrices by synchrotron oscillation as well as by a transverse RF field. From this point of view, a fast beam cut-off method has been proposed and verified by both simulations and experiments. The maximum delay from the beam cut-off signal to beam-off has been improved to around 60 mu s from 700 mu s by a usual method. Unwanted dose has been considerably reduced by around a factor of 10 compared with that by the usual method.

  9. "Cut-off" effect of antioxidants and/or probes of variable lipophilicity in microheterogeneous media.

    Aliaga, Carolina; López de Arbina, Amaia; Rezende, Marcos Caroli

    2016-09-01

    The activities of two hydrophilic (ascorbic acid and Trolox) and two hydrophobic (α-tocopherol and BHT) antioxidants were measured by reaction with a series of 4-alkanoyloxyTEMPO radical probes 1 in buffered (pH 7), aqueous, micellar solutions of reduced Triton-X 100. In all cases, a cut-off effect was observed, in line with previous observations of the same effect for the partitioning of probe series 1 in this medium. These results support an interpretation of the cut-off effect in food emulsions, based on the "amphiphobic" nature of either the antioxidants or probes: competition between two molecular moieties, for the micellar hydrophobic core, tends to expose a reacting fragment differently to a more hydrophilic microenvironment, as the probe or antioxidant hydrophobicity increases. PMID:27041306

  10. Edge plasmons and cut-off behavior of graphene nano-ribbon waveguides

    Hou, Haowen; Teng, Jinghua; Palacios, Tomás; Chua, Soojin

    2016-07-01

    Graphene nano-ribbon waveguides with ultra-short plasmon wavelength are a promising candidate for nanoscale photonic applications. Graphene edge plasmons are the fundamental and lowest losses mode. Through finite element method, edge plasmons show large effective refractive index and strong field confinement on nanoscale ribbons. The edge plasmons follow a k1/2 dispersion relation. The wavelengths of the edge plasmons and center plasmons differ by a fixed factor. The width of edge plasmon is inversely proportional to wave vector of edge plasmon kedge. Edge defects associate with graphene nano-ribbon induce extra losses and reduce the propagation length. Cut-off width of edge plasmons reduces with increasing frequency. Cut-off width of center plasmon is enlarged by edge component but the enlargement effect diminishing with the increase of kedge. The results are important for the application of graphene plasmon towards ultra-compact photonic devices.

  11. Interacting Entropy-Corrected Holographic Dark Energy and IR Cut-Off Length

    Sadeghi, J.; Pourhassan, B.; Abbaspour Moghaddam, Z.

    2014-01-01

    In this paper we consider holographic dark energy model with corrected holographic energy density and show that this model may be equivalent to the modified Chaplygin gas model. Then we obtain relation between entropy corrected holographic dark energy model and scalar field models. We do these works by using choices of IR cut-off length proportional to the Hubble radius, the event horizon radius, the Ricci length, and the Granda-Oliveros length.

  12. Interacting Entropy-Corrected Holographic Dark Energy and IR Cut-Off Length

    Sadeghi, J; Moghaddam, Z Abbaspour

    2013-01-01

    In this paper we consider holographic dark energy model with corrected holographic energy density and show that this model may be equivalent to the modified Chaplygin gas model. Then we obtain relation between entropy corrected holographic dark energy model and scalar field models. We do these works by using choices of IR cut-off length proportional to the Hubble radius, the event horizon radius, the Ricci length, and the Granda-Oliveros length.

  13. Validity of Alternative Cut-Off Scores for the Back-Saver Sit and Reach Test

    Looney, Marilyn A.; Gilbert, Jennie

    2012-01-01

    The purpose of the study was to determine if currently used FITNESSGRAM[R] cut-off scores for the Back Saver Sit and Reach Test had the best criterion-referenced validity evidence for 6-12 year old children. Secondary analyses of an existing data set focused on the passive straight leg raise and Back Saver Sit and Reach Test flexibility scores of…

  14. Sensitivity studies of spin cut-off models on fission fragment observables

    Thulliez L.; Litaize O.; Serot O.

    2016-01-01

    A fission fragment de-excitation code, FIFRELIN, is being developed at CEA Cadarache. It allows probing the characteristics of the prompt emitted particles, neutrons and gammas, during the de-excitation process of fully accelerated fission fragments. The knowledge of the initial states of the fragments is important to accurately reproduce the fission fragment observables. In this paper a sensitivity study of various spin cut-off models, completely defining the initial fission fragment angular...

  15. Effectiveness and Cut off Points of Anthropometric Measurements in Predicting Metabolic Syndrome in Turkish Women

    Sultan Keskin Demircan1

    2016-03-01

    Full Text Available Objective: Examination of the anthropometric methods and cut off points that are most appropriate to predict metabolic syndrome (MS for the female Turkish population. Methods: Waist circumference (WC, waist-hip ratio (WHR, body mass index (BMI, arm circumference (AC, total skin thickness (TST using caliper, body fat percentage (BFP and fat free mass (FFM using bioelectrical impedance were taken in 202 female patients. Blood glucose, lipid panel and blood pressure were also checked. We defined two different MS excluding anthropometric measurements. Low HDL and high triglyceride were separate criteria in the first definition; dyslipidemia was defined one criteria as low HDL and/or high triglyceride and/or triglyceride/HDL≥3 in the second. Efficiency, sensitivity and specificity of anthropometric measurements in predicting MS criteria were assessed using ROC analysis. Results: When compared in determining three or more of the MS parameters of dysglicemia, low HDL, high triglyceride and hypertension, BMI, WC, BFP, WHR and AC were found to be significant (p<0.0001. TST was significant as well (p=0.001. FFM was insignificant (p=0.337. Cut off points for BMI, WC and WHR in predicting MS were 27.7 kg/m2, 92.5 cm, 0.86. When dyslipidemia was defined in one criteria, cut off points were found similarly 27.8 kg/m2, 92.5 cm, 0.86. Conclusion: BMI, WHR, BFP and WC were more valuable than TST and AC in predicting MS but they had no statistically significant superiority over each other. However, with a 95% confidence interval, predictive cut off points were significantly above those observed in western populations.

  16. Cut-off proposal for the detection of ketamine in hair.

    Salomone, A; Gerace, E; Diana, P; Romeo, M; Malvaso, V; Di Corcia, D; Vincenti, M

    2015-03-01

    Ketamine is a powerful anesthetic drug used in both human and veterinary surgery, but it is also commonly misused because of its psychotropic properties. Since the abuse of this drug has been reported in many countries worldwide, its determination in hair samples is offered as a specialist test by hundreds of laboratories. However, unlike other common drugs of abuse, a cut-off level for ketamine in hair has not been fixed yet. Therefore, aim of this study is to propose a concentration value for ketamine in hair analysis, in order to discriminate between chronic and occasional use, and between active use and external contamination. After considering the chemical properties of this molecule, and the experimental data collected in our laboratory or reported in several other published studies, we propose a cut-off level of 0.5ng/mg, as indicative of repeated exposure to ketamine. Additionally, we suggest that the detection of the metabolite norketamine should be mandatory to prove active intake and exclude false positive result from external contamination. Thus, a reasonable cut-off value for norketamine could be fixed at 0.1ng/mg, while the minimal concentration ratio norketamine/ketamine may be positively established at 0.05. PMID:25616219

  17. Spectral geometry with a cut-off: topological and metric aspects

    D'Andrea, Francesco; Martinetti, Pierre

    2013-01-01

    Inspired by regularization in quantum field theory, we study topological and metric properties of spaces in which a cut-off is introduced. We work in the framework of noncommutative geometry, and focus on Connes distance associated to a spectral triple (A,H,D). A high momentum (short distance) cut-off is implemented by the action of a projection P on the Dirac operator D and/or on the algebra A. This action induces two new distances. We first individuate conditions making them equivalent to the original distance. We then study the Gromov-Hausdorff limit of the set of truncated states, first for quantum metric spaces in the sense of Rieffel, and then for arbitrary spectral triples. In the commutative case, we show that the cut-off induces a minimal length between points, which is infinite if P has finite rank. When P is a spectral projection of D, we work out an approximation of points by non-pure states that are at finite distance from each other. We apply the results to Moyal plane and to the fuzzy sphere, o...

  18. Impact of cut-off probability on emergency planning zone sizing for advanced light water reactors

    In 1997, NRC performed an evaluation of emergency planning for the evolutionary and advanced light water reactors, and indicated that no changes to emergency planning (EP) requirements were warranted in the existing technical framework. How- ever, NRC also recognized if the lower probability of severe accidents or the longer time period between accident initiation and release of radioactive material was considered, the changes to EP requirements for advanced light water reactors might be warranted and the emergency planning zone (EPZ) sizing might be reduced. This means that if the accidents which probabilities are lower than a cut-off probability are not considered, there may be a significant impact on the EPZ sizing. AP1000 was selected as an example in this study and the probable impacts of different cut-off probabilities were studied by using MACCS code in accordance with the NUREG-0396 method. The results show that, only if the cut-off probability is higher than the occurrence probability of the accident which has relatively serious consequence and high probability, there will be a significant impact on the EPZ sizing for the advanced light water reactor. (authors)

  19. Evaluation of novel large cut-off ultrafiltration membranes for adenovirus serotype 5 (Ad5 concentration.

    Piergiuseppe Nestola

    Full Text Available The purification of virus particles and viral vectors for vaccine and gene therapy applications is gaining increasing importance in order to deliver a fast, efficient, and reliable production process. Ultrafiltration (UF is a widely employed unit operation in bioprocessing and its use is present in several steps of the downstream purification train of biopharmaceuticals. However, to date few studies have thoroughly investigated the performance of several membrane materials and cut-offs for virus concentration/diafiltration. The present study aimed at developing a novel class of UF cassettes for virus concentration/diafiltration. A detailed study was conducted to evaluate the effects of (i membrane materials, namely polyethersulfone (PES, regenerated cellulose (RC, and highly cross-linked RC (xRC, (ii nominal cut-off, and (iii UF device geometry at different production scales. The results indicate that the xRC cassettes with a cut-off of approximately 500 kDa are able to achieve a 10-fold concentration factor with 100% recovery of particles with a process time twice as fast as that of a commercially available hollow fiber. DNA and host cell protein clearances, as well as hydraulic permeability and fouling behavior, were also assessed.

  20. Relevance of Interleukin-6 and D-Dimer for Serious Non-AIDS Morbidity and Death among HIV-Positive Adults on Suppressive Antiretroviral Therapy.

    Birgit Grund

    Full Text Available Despite effective antiretroviral treatment (ART, HIV-positive individuals are at increased risk of serious non-AIDS conditions (cardiovascular, liver and renal disease, and cancers, perhaps due in part to ongoing inflammation and/or coagulation. To estimate the potential risk reduction in serious non-AIDS conditions or death from any cause that might be achieved with treatments that reduce inflammation and/or coagulation, we examined associations of interleukin-6 (IL-6, D-dimer, and high-sensitivity C-reactive protein (hsCRP levels with serious non-AIDS conditions or death in 3 large cohorts.In HIV-positive adults on suppressive ART, associations of IL-6, D-dimer, and hsCRP levels at study entry with serious non-AIDS conditions or death were studied using Cox regression. Hazard ratios (HR adjusted for age, gender, study, and regression dilution bias (due to within-person biomarker variability were used to predict risk reductions in serious non-AIDS conditions or death associated with lower "usual" levels of IL-6 and D-dimer.Over 4.9 years of mean follow-up, 260 of the 3766 participants experienced serious non-AIDS conditions or death. IL-6, D-dimer and hsCRP were each individually associated with risk of serious non-AIDS conditions or death, HR = 1.45 (95% CI: 1.30 to 1.63, 1.28 (95% CI: 1.14 to 1.44, and 1.17 (95% CI: 1.09 to 1.26 per 2x higher biomarker levels, respectively. In joint models, IL-6 and D-dimer were independently associated with serious non-AIDS conditions or death, with consistent results across the 3 cohorts and across serious non-AIDS event types. The association of IL-6 and D-dimer with serious non-AIDS conditions or death was graded and persisted throughout follow-up. For 25% lower "usual" IL-6 and D-dimer levels, the joint biomarker model estimates a 37% reduction (95% CI: 28 to 46% in the risk of serious non-AIDS conditions or death if the relationship is causal.Both IL-6 and D-dimer are independently associated with

  1. Defining a BMI Cut-Off Point for the Iranian Population: The Shiraz Heart Study.

    Babai, Mohammad Ali; Arasteh, Peyman; Hadibarhaghtalab, Maryam; Naghizadeh, Mohammad Mehdi; Salehi, Alireza; Askari, Alireza; Homayounfar, Reza

    2016-01-01

    In this study we evaluated and redefined the optimum body mass index (BMI) cut-off point for the Iranian population based on metabolic syndrome (MeS) risk factors. We further evaluated BMI cut-off points with and without waist circumference (WC) as a cofactor of risk and compared the differences. This study is part of the largest surveillance programs conducted in Shiraz, Iran, termed the Shiraz Heart study. Our study sample included subjects between the ages of 20 to 65 years old. After excluding pregnant women, those with missing data and those with comorbid disease, a total of 12283 made up the study population. The participants underwent a series of tests and evaluations by trained professionals in accordance with WHO recommendations. Hypertension, abnormal fasting blood sugar (FBS), triglyceride (TG) and high density lipoprotein cholesterol (HDL) (in the context of the definition of metabolic syndrome) were prevalent among 32.4%, 27.6%, 42.1 and 44.2% of our participants, respectively. Women displayed higher rates of overall obesity compared to men (based on the definition by the WHO as higher than 30 kg/m2). Regarding MeS, 38.9% of our population had the all symptoms of MeS which was more prevalent among women (41.5% vs. 36%). When excluding WC in the definition of MeS, results showed that males tend to show a higher rate of metabolic risk factors (19.2% vs. 15.6%). Results of multivariate analysis showed that parallel to an increase in BMI, the odds ratio (OR) for acquiring each component of the metabolic syndrome increased (OR = 1.178; CI: 1.166-1.190). By excluding WC, the previous OR decreased (OR = 1.105; CI: 1.093-1.118). Receiver Operating Characteristic (ROC) curve analysis showed that the optimum BMI cut-off point for predicting metabolic syndrome was 26.1 kg/m2 and 26.2 kg/m2 [Accuracy (Acc) = 69% and 61%, respectively)] for males and females, respectively. The overall BMI cut-off for both sexes was 26.2 kg/m2 (Acc = 65%) with sensitivity and

  2. Determination of a saliva cotinine cut-off to distinguish pregnant smokers from pregnant non-smokers

    Hegaard, Hanne K; Kjaergaard, Hanne; Møller, Lars F;

    2007-01-01

    Objective validation of smoking status is necessary. Earlier studies have used saliva cotinine concentrations between 14.2 and 30 ng/ml as cut-off values to distinguish pregnant smokers from non-smokers. However, these cut-offs derive from studies including men and non-pregnant women. This...... constitutes a problem, as recent studies have reported an accelerated metabolism in pregnant smokers. The aim of this study was to determine the optimum cut-off cotinine level distinguishing pregnant smokers from pregnant non-smokers....

  3. Brug af D-dimer til at udelukke dyb venøs trombose i overekstremiteterne

    Ahler-Toftehøj, Hans-Ulrik; Mikkelsen, Peter

    2009-01-01

    D-dimer is often used to exclude deep venous thrombosis, primarily in the lower extremities. We describe a 38-year-old man who had deep venous thrombosis in the left vena subclavia in spite of a normal D-dimer. Only one inconclusive survey compares the value of D-dimer and upper extremity deep...... venous thrombosis. We conclude that where deep venous thrombosis of the upper extremities is suspected, you cannot rely on the D-dimer value, but should examine the patient using other modalities such as colour Doppler ultrasound. Udgivelsesdato: 2009-Sep...

  4. Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults

    Smith, N. L.; J.E. Huffman; Strachan, D. P.; Huang, J.; A. Dehghan; Trompet, S.; Lopez, L.M. (Lorna M.); Shin, S.-Y.; Baumert, J.; Vitart, V; Bis, J.C.; Wild, S.H.; Rumley, A; Yang, Q.; Uitterlinden, A G

    2011-01-01

    Background-Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. Methods and Results-A genome-wide investigation of the genomic correlates of plasma D-dimer levels was conducted among 21 052 European-ancestry adults. Plasma levels of D-dimer were measu...

  5. On-site raw gas cut-off during the shut down of Baosteel phase I coke ovens

    ZHOU Haizhong

    2015-01-01

    The preparation and implementation of raw coke oven gas cut-off,which was the key process involved with shutting down the Baosteel phase I coke ovens,were investigated,and the main technical points and countermeasures are presented.

  6. Ultrahigh energy neutrinos scattering off relic light neutrinos to explain UHECR above GZK cut off and thin blazars

    Fargion, D; Fargion, Daniele; Mele, Barbara

    1999-01-01

    UHE neutrinos may transfer highest cosmic-rays energies overcoming $2.75K^\\circ$ BBR and radio-waves opacities (the GZK cut off) from most distant AGN sources at the age of the Universe. These UHE $\

  7. D-dimer: a useful tool in gauging optimal duration of oral anticoagulant therapy?

    M. Silingardi

    2013-05-01

    Full Text Available BACKGROUND AND AIM OF THE STUDY Optimal duration of oral anticoagulant therapy (OAT in idiopathic venous thromboembolism (VTE is unknown. Indefinite OAT carries an unacceptable risk of major bleeding and prospective studies have demonstrated that OAT is no longer protective after its withdrawal. How to identify the patients at risk for recurrence? D-dimer is a marker of thrombin activity. Early prospective studies showed that elevated D-dimer levels after anticoagulation had a highly predictive value for a recurrent episode. Does D-dimer assay have a role in gauging the appropriate duration of anticoagulant therapy? The PROLONG study tries to answer this question. METHOD D-dimer assay was performed one month after stopping anticoagulation. Patiens with normal D-dimer levels did not resume anticoagulation while patients with elevated D-dimer levels were randomized to discontinue or resume anticoagulation. Study end-points was the composite of recurrent VTE and major bleeding during an average follow-up of 1.4 years. RESULTS The rate of recurrence is significantly higher in patients with elevated D-dimer levels who discontinued anticoagulation. Resuming anticoagulation in this cohort of patients markedly reduces recurrent events without increasing major bleeding. DISCUSSION AND CONCLUSIONS PROLONG study is provocative, because D-dimer assay is simple, thus not requiring dedicated laboratory facilities. D-dimer test has otherwise high sensitivity but low specificity in VTE diagnosis. Aspecifically elevated D-dimer levels are available in the elderly and the majority of patients included in the study were > 65 years old, thus introducing a possible selection bias. Nonetheless the results of the study are useful for the clinician. Prolongation of vitamin K antagonists in patients with elevated D-dimer levels one month after discontinuation of OAT for a first unprovoked episode of VTE results in a favourable risk-benefit relationship. Probably this

  8. Lowering the cut off value of an automated chlamydia enzyme immunoassay and confirmation by PCR and direct immunofluorescent antibody test.

    Tong, C Y; Donnelly, C; Hood, N

    1997-01-01

    AIMS: To increase the sensitivity of an automated chlamydia enzyme immunoassay by significantly lowering its cut off value, and to maintain specificity by confirmation with polymerase chain reaction (PCR) and direct immunofluorescent antibody test (DFA). METHODS: Over five months, the cut off value of the enzyme immunoassay used to screen urogenital samples for chlamydia antigen was reduced from 80 to 10. Samples with a test value of 10 or above were further tested with a commercial PCR assay...

  9. Cut-off values of blessed dementia rating scale and its clinical application in elderly Taiwanese.

    Yang, Yuan-Han; Lai, Chiou-Lian; Lin, Ruey-Tay; Tai, Chih-Ta; Liu, Ching-Kuan

    2006-08-01

    Although the Blessed Dementia Rating Scale (BDRS), a clinical screening instrument, has been applied extensively, no suitable cut-off values and clinical application have been proposed, particularly in mild cognitive impairment (MCI), the precursor of dementia. The BDRS, Mini Mental State Examination (MMSE), and Clinical Dementia Rating Scale (CDR) were administrated in people aged 65 years and above, who were enrolled from southern Taiwan with multistep stratified random sampling and followed-up for 2 years. All subjects (total number = 3,027), with new onset of MCI (defined as CDR = 0.5) in the first year and dementia (defined as CDR > or = 1) in the second and third years were subjected to statistical analysis. In distinguishing normal from MCI, except in the literate group aged 65-74 years, MMSE was superior to BDRS, with cut-off values of 1 in both literate groups aged 65-74 years and > or = 75 years, and 1.5 and 2 in less educated groups aged 65-74 and > or = 75 years, respectively. In distinguishing MCI from dementia, BDRS had cut-off values of 2.5 in both literate groups aged 65-74 and > or = 75 years, and 2.5 and 3 in less educated groups aged 65-74 and > or = 75 years, respectively. These values were better than those for MMSE in all groups. BDRS might be considered as a better tool than MMSE to screen for MCI and dementia in the increasing proportion of literate elderly aged 65-74 years in the aging population. PMID:16911919

  10. Aligning DNA on Si surface and cutting off by tips of atomic force microscope

    2003-01-01

    DNA is a kind of promising molecule as nano-lead to build or connect nano-devices due to its stable linear structure and certain conductivity. Many methods have been applied to constructing nano-patterns by using DNA molecule. In this report it is presented that (-DNA was aligned on Si substrate by using the free-flowing method and then imaged by an atomic force microscope (AFM). After the second liquid flow, a catenary-like pattern and a crossed network of -DNA were formed. In addition, the aligned (-DNA was successfully cut off by tips of AFM.

  11. Sensitivity studies of spin cut-off models on fission fragment observables

    Thulliez L.

    2016-01-01

    Full Text Available A fission fragment de-excitation code, FIFRELIN, is being developed at CEA Cadarache. It allows probing the characteristics of the prompt emitted particles, neutrons and gammas, during the de-excitation process of fully accelerated fission fragments. The knowledge of the initial states of the fragments is important to accurately reproduce the fission fragment observables. In this paper a sensitivity study of various spin cut-off models, completely defining the initial fission fragment angular momentum distribution has been performed. This study shows that the choice of the model has a significant impact on gamma observables such as spectrum and multiplicity and almost none on the neutron observables.

  12. Sensitivity studies of spin cut-off models on fission fragment observables

    Thulliez, L.; Litaize, O.; Serot, O.

    2016-03-01

    A fission fragment de-excitation code, FIFRELIN, is being developed at CEA Cadarache. It allows probing the characteristics of the prompt emitted particles, neutrons and gammas, during the de-excitation process of fully accelerated fission fragments. The knowledge of the initial states of the fragments is important to accurately reproduce the fission fragment observables. In this paper a sensitivity study of various spin cut-off models, completely defining the initial fission fragment angular momentum distribution has been performed. This study shows that the choice of the model has a significant impact on gamma observables such as spectrum and multiplicity and almost none on the neutron observables.

  13. On the discovery of the Greisen–Zatzepin–Kuzmin cut-off

    Tadeusz Wibig

    2009-11-01

    The recent claim of the `5 sigma' observation of the Greisen–Zatzepin–Kuzmin cut-off by the HiRes group based on their nine years data is a significant step towards the eventual solution of one of the most intriguing questions in physics for more than 40 years. Recent results from Pierre Auger Observatory seem to confirm the statement. However, the word `significance' is used in the mentioned paper in a sense which is not quite obvious. In the present paper we argue that this claim is a little premature.

  14. European quality assurance and quality control for cut-off walls and caps

    Cut-off walls and caps both may be seriously compromised by small areas of substandard materials or work. Quality assurance/quality control is therefore of crucial importance and the paper sets out the issues that need to be addressed when designing a quality plan for a containment. Consideration is given to the purpose of the containment, the parameters to be controlled, specifications and standards and tests on raw and manufactured materials and on the in-situ containment. It is not the purpose of the paper to give detailed test procedures but rather to identify the questions that must be answered to develop a quality plan

  15. Observation and calculation of trapped modes near cut-off in the ALS bellow-shield

    Observed heating of the RF shields in the bellows of the Advanced Light Source (ALS) storage ring has led to studies of possible causes. One such possibility is resonant impedances near the cut-off frequency of the beam-pipe that arise from small, localized, enlargements of the beampipe cross-section. Calculations of trapped modes in the elliptical-section vacuum chamber, approximated by a rectangular geometry, are described. Measurements of a bellows-shield in the test laboratory are also described, as are temperature measurements of a flexband in the storage ring

  16. Factors associated with D-dimer levels in HIV-infected individuals

    Borges, Alvaro H; O'Connor, Jemma L; Phillips, Andrew N;

    2014-01-01

    than men, though a steeper increase of D-dimer with age occurred in men. Hepatitis B/C co-infection was the only co-morbidity associated with higher D-dimer levels. In this subgroup, the degree of hepatic fibrosis, as demonstrated by higher hyaluronic acid levels, but not viral load of hepatitis...

  17. Evaluation of Serum D-dimer Levels in Children with Pneumonia

    Nilgün Selçuk Duru

    2016-03-01

    Full Text Available Aim: The aim of this study was to investigate the relationship of plasma D-dimer levels with duration of hospitalization and radiological and laboratory findings in patients with pneumonia. Methods: Forty-seven patients with pneumonia (31 boys and 16 girls, mean age: 4.2±4.7 years were included in the study. The patients were divided into two groups according to duration of hospitalization and three groups according to radiological findings. D-dimer and other laboratory findings were compared between the groups. Results: The mean serum D-dimer level was 1333.5±1364.4 ng/L. There was no statistically significant difference in D-dimer, leukocyte, erythrocyte sedimentation rate (ESR and C-reactive protein (CRP between the groups divided according to duration of hospitalization. In addition, there was no statistically difference in D-dimer levels between the groups divided according to radiological findings. Age, percentage of neutrophils, ESR and fibrinogen levels were higher in patients with lobar pneumonia when compared with the other groups and CRP level was higher in lobar pneumonia group when compared to interstitial pneumonia group. D-dimer levels were negatively correlated with age and positively correlated with ESR, CRP, and fibrinogen. Conclusion: In our study, D-dimer levels were high in patient with pneumonia. Further studies with a larger number of patients are necessary to determine the role of D-dimer levels as an acutephase reactant in patients with pneumonia

  18. Genetic predictors of fibrin D-dimer levels in healthy adults

    N.L. Smith (Nicholas); J.E. Huffman (Jennifer E.); D.P. Strachan (David); J. Huang (Jian); A. Dehghan (Abbas); S. Trompet (Stella); L.M. Lopez (Lorna M.); S.Y. Shin (So Youn); J. Baumert (Jens); V. Vitart (Veronique); J.C. Bis (Joshua); S.H. Wild (Sarah); A. Rumley (Ann); Q. Yang (Qiong Fang); A.G. Uitterlinden (André); D.J. Stott (David. J.); G. Davies (Gareth); A.M. Carter (Angela M.); B. Thorand (Barbara); O. Polašek (Ozren); B. McKnight (Barbara); H. Campbell (Harry); A.R. Rudnicka (Alicja); M.H. Chen (Min-hsin); B.M. Buckley (Brendan M.); S.E. Harris (Sarah); A. Peters (Annette); D. Pulanic (Drazen); T. Lumley (Thomas); A.J.M. de Craen (Anton J.M.); D.C. Liewald (David C.); C. Gieger (Christian); I. Ford (Ian); A.J. Gow (Alan J.); M. Luciano (Michelle); D.J. Porteous (David J.); X. Guo (Xiuqing); N. Sattar (Naveed); A. Tenesa (Albert); M. Cushman (Mary Ann); P.E. Slagboom (Eline); P.M. Visscher (Peter M.); T.D. Spector (Tim); T. Illig (Thomas); I. Rudan (Igor); E.G. Bovill (Edwin G.); A.F. Wright (Alan); W.L. McArdle (Wendy); G.H. Tofler (Geoffrey); A. Hofman (Albert); R.G.J. Westendorp (Rudi); J.M. Starr (John); P.J. Grant (Peter J.); M. Karakas (Mahir); N.D. Hastie (Nicholas D.); B.M. Psaty (Bruce); J.F. Wilson (James); G.D.O. Lowe (Gordon); C.J. O'Donnell (Christopher); J.C.M. Witteman (Jacqueline); J.W. Jukema (Jan Wouter); I.J. Deary (Ian); N. Soranzo (Nicole); W. Koenig (Wolfgang); C. Hayward (Caroline)

    2011-01-01

    textabstractBACKGROUND: Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wi

  19. Relation between wall motion and scintigraphic uptake altered by the cut-off level on technetium-99m sestamibi tomographic imaging. The preferable cut-off levels according to tomographic uptake correlated with the wall motion

    Whether technetium-99m sestamibi imaging can evaluate myocardial viability is still obscure. It may be partially because the preferable cut-off level for evaluation of the viability is not known. This study was aimed to investigate which cut-off level should be used for estimation of the contractile function, and verify whether technetium-99m sestamibi tomographic imaging can evaluate myocardial viability. We studied 45 patients who had myocardial infarction. They underwent technetium-99m sestamibi imaging, echocardiography, and cardiac catheterization. The myocardial image was divided into 16 segments, each of which was scored according to wall motion on echocardiography with a 4-point scale. The segmental technetium-99m uptake was also scored with a 4-point scale. We investigated the correlation between wall motion and scintigraphic uptake with the use of 7 cut off levels (from 35% to 65%, in 5% increments). The correlation ranks were compared among patient groups with a number of stenotic vessels. Irrespective of the number of stenotic vessels, the defect score was similarly enlarged according to cut-off levels. The patient groups had the maximum correlation ranks with different cut-off levels, which were 40% for 1-vessel disease (ρ=0.512, n=160, p=0.0001), 50% for 2-vessel disease (ρ=0.424, n=208, p=0.0001), and 60% for 3-vessel disease (ρ=0.540, n=272, p=0.0001). The correlation ranks for all groups were stable, whereas not high, throughout various cut-off levels. Technetium-99m sestamibi imaging can approximately estimate myocardial viability from the point of view of function, which may be corrected by the careful choice of cut off levels according to the number of the stenotic vessels (40% for 1-vessel disease, 50% for 2-vessel disease, 60% for 3-vessel disease). (author)

  20. Changes in fibrin D-dimer, fibrinogen, and protein S during pregnancy

    Hansen, Anette Tarp; Andreasen, Birgitte Horst; Salvig, Jannie Dalby;

    2010-01-01

    Background. Pregnancy is a hypercoagulable state with a 5- to 10- fold higher risk of venous thromboembolism. Existing reference intervals for fibrin D-dimer (D-dimer), functional fibrinogen (fibrinogen) and protein S, free antigen (protein S) are based on non-pregnant patients and reference...... intervals for pregnant patients are warranted. Objectives. The aim of the present study was to contribute to the establishment of reference intervals for D-dimer, fibrinogen and protein S during pregnancy and to discuss the use of the analyses during pregnancy. Methods. We included 55 healthy pregnant women...... in gestational week 11–17, with normal current pregnancy. Blood samples were collected in gestational weeks 11–17, 21–27 and 34–37. The three plasma parameters D-dimer, fibrinogen and protein S were analysed by STA-R Evolution®. Results. A significant rise in D-dimer was found from first to second trimester (p...

  1. Revisiting AdS/CFT at a finite radial cut-off

    Mandal, Gautam

    2016-01-01

    We revisit AdS/CFT at finite radial cut-off, specifically in the context of double trace perturbations, $\\mathbb{O}_n$= $\\mathbb{O}(x) (\\partial^2)^{n} {\\mathcal O}(x)$, with arbitrary $n$. As well-known, the standard GKPW prescription, applied to a finite radial cut-off, leads to contact terms in correlators. de Haro et al \\cite{deHaro:2000vlm} introduced bulk counterterms to remove these. However, this prescription yields additional terms in the correlator corresponding to spurious double trace deformations. Further, if we view GKPW prescription coupled with the prescription in \\cite{deHaro:2000vlm}, in terms of a boundary wavefunction, we find that it is incompatible with radial Schrodinger evolution (in the spirit of holographic Wilsonian RG). We consider a more general wavefunction satisfying the Schrodinger equation, and find that generically such wavefunctions generate both (a) double trace deformations and (b) contact terms. However, we find that there exist special choices of these wavefunctions, amo...

  2. Open Skies and monitoring a fissile materials cut-off treaty

    The Treaty on Open Skies (Open Skies) is intended among other things to provide, in the words of its preamble, means ''to facilitate the monitoring of compliance with existing or future arms control agreements.'' Open Skies permits overflights of the territory of member states by aircraft equipped with an array of sensors of various types. Their types and capabilities are treaty-limited. To find useful application in monitoring a cut-off treaty Open Skies would need to be amended. The number of signatories would need to be expanded so as to provide greater geographical coverage, and restrictions on sensor-array capabilities would need to be relaxed. To facilitate the detection of impending violations of a cut-off convention by Open Skies overflights, the data base provided by parties to the former should include among other things an enumeration of existing and former fuel cycle and research facilities including those converted to other uses, their precise geographic location, and a site plan

  3. Proceedings from the Fissile Material Cut-off seminar in Stockholm

    Arbman, G. [ed.

    1998-07-01

    The Swedish Defence Research Establishment hosted an international expert seminar on the subject of verifying a prohibition of the production of fissile material for nuclear weapons purpose (cut-off) in Stockholm, June 3-5 1998. The objective of the seminar was to provide an opportunity for informal discussions among scientific and technical experts on various technical matters relating to the verification of a future Fissile Material Cut-off Treaty (FMCT). A stated aim of the seminar was to keep issues of scope to a minimum. Invited speakers and commentators were given an opportunity to present their views as written contributions. The present seminar proceedings are essentially the result of these views. In addition, short summaries of the discussions following each session are included. Although an attempt was made to be as complete and accurate as possible in reproducing these discussions, the editors apologise if some important points or statements have been omitted. If so, the main reason is that the documentation of the discussions were based on written notes, not taped recordings. Eight longer contributions have been separately indexed.

  4. Cut-Off Values of Visceral Adiposity to Predict NAFLD in Brazilian Obese Adolescents

    Ana Paula Grotti Clemente

    2013-01-01

    Full Text Available Objectives. The present study aimed at determining cut-off points of visceral fat to predict NAFLD and analyzed metabolic disorders of obese adolescents. Methods. Cross-sectional study involved 165 obese adolescents ranged in age from 15 to 19 years. Glycemia, hepatic transaminases, lipid profile, and insulin resistance were analyzed. Visceral and subcutaneous fat were measured by ultrasound and body composition by plesthysmography. Results. The NAFLD adolescents had significantly higher values for body mass, BMI-for-age, BMI, total fat, waist circumference, and visceral fat when compared with non-NAFLD obese adolescents in both genders. Moreover, there were significant positive correlations between visceral fat with the variables BMI-for-age (r=0.325,, TG (r=0.277, AST (r=0.509, ALT (r=0.519, WC (r=0.390, and visceral/subcutaneous ratio (r=0.790 for NAFLD group. Total fat, triglycerides, and visceral fat were the independent predictors to NAFLD. Analysis of the ROC curves revealed cut-off points of visceral fat of 4.47 cm for girls and 4.21 cm for boys. Conclusions. The results may suggest that abdominal ultrasonography procedure may be a safe alternative method of assessing visceral adiposity aiming to be considered to the development of preventive and treatment strategies in obese individuals. This clinial trial is registered with ClinicalTrial.gov (NCT01358773.

  5. The cut-off criterion for a positive hydrogen breath test in children: a reappraisal.

    Solomons, N W; Barillas, C

    1986-01-01

    Seventy-three preschool children with adequate nutritional status underwent interval-sampling, 3-hour breath-hydrogen carbohydrate absorption tests after consuming either 240 ml of intact milk (containing 12 g of lactose) or the same volume of milk with 90-95% of its lactose prehydrolyzed in vitro (containing less than 1 g lactose, with the remaining sugar as glucose and galactose). Results were examined in a reappraisal of the cut-off criterion for the rise of breath H2 concentration signifying biologically incomplete absorption. If the greater than or equal to 10-ppm criterion advocated by some investigators is used, 83% of our subjects would have been classified as incomplete lactose digesters and 30% would have their tests with the monosaccharide-rich milk classified as positive. With the greater than or equal to 20 ppm criterion used in our laboratory and others, the prevalence of lactose maldigestion in the sample becomes 60% and only 4% of subjects have apparent monosaccharide absorption, 96% having a rise below the cut-off level with prehydrolyzed milk. At least in Guatemalan preschoolers, the 20-ppm criterion for a positive breath H2 test provides a superior specificity-sensitivity balance and more reasonable diagnostic conclusions. PMID:3794911

  6. Proceedings from the Fissile Material Cut-off seminar in Stockholm

    The Swedish Defence Research Establishment hosted an international expert seminar on the subject of verifying a prohibition of the production of fissile material for nuclear weapons purpose (cut-off) in Stockholm, June 3-5 1998. The objective of the seminar was to provide an opportunity for informal discussions among scientific and technical experts on various technical matters relating to the verification of a future Fissile Material Cut-off Treaty (FMCT). A stated aim of the seminar was to keep issues of scope to a minimum. Invited speakers and commentators were given an opportunity to present their views as written contributions. The present seminar proceedings are essentially the result of these views. In addition, short summaries of the discussions following each session are included. Although an attempt was made to be as complete and accurate as possible in reproducing these discussions, the editors apologise if some important points or statements have been omitted. If so, the main reason is that the documentation of the discussions were based on written notes, not taped recordings. Eight longer contributions have been separately indexed

  7. Short-range Cut-Off of the Summed-Up van der Waals Series

    Patra, Abhirup; Perdew, John P.

    2015-03-01

    van der Waals interactions are important in typical van der Waals-bound systems such as noble-gas, hydrocarbon, alkali and alkaline-earth dimers. The summed-up van der Waals series works well and gives an accurate result at large separation between two atoms. But it has a strong singularity at short non-zero separation, where the two atoms touch. In this work we remove that singularity with a reasonable and physical choice of the cut-off distance. Only one fitting parameter has been introduced for the short-range cut off. The parameter in our model has been optimized for each system, and a system-averaged value has been used to get the final binding energy curves. When this correction is added to the binding energy curve from the semilocal density functional meta-GGA-MS2, we get vdW- corrected binding energy curve. These curves are compared with the results of other vdW-corrected methods such as PBE-D2 and vdW-DF2 .Binding energy curves are in reasonable agreement with those from experiment. These curves also predict reasonably good equilibrium bond length. Supported by NSF (DMR).

  8. Open Skies and monitoring a fissile materials cut-off treaty

    Allentuck, J.; Lemley, J.R.

    1995-09-01

    The Treaty on Open Skies (Open Skies) is intended among other things to provide, in the words of its preamble, means ``to facilitate the monitoring of compliance with existing or future arms control agreements.`` Open Skies permits overflights of the territory of member states by aircraft equipped with an array of sensors of various types. Their types and capabilities are treaty-limited. To find useful application in monitoring a cut-off treaty Open Skies would need to be amended. The number of signatories would need to be expanded so as to provide greater geographical coverage, and restrictions on sensor-array capabilities would need to be relaxed. To facilitate the detection of impending violations of a cut-off convention by Open Skies overflights, the data base provided by parties to the former should include among other things an enumeration of existing and former fuel cycle and research facilities including those converted to other uses, their precise geographic location, and a site plan.

  9. Appropriate body mass index cut-offs to determine thinness, overweight and obesity in South Asian children in the Netherlands.

    Jeroen A de Wilde

    Full Text Available BACKGROUND: Asian populations have an increased risk of developing cardiometabolic disorders at a lower body mass index (BMI than other ethnic groups. Therefore, lower adult BMI cut-offs to determine overweight and obesity are recommended to assess the associated health risks for Asian (23 and 27.5 kg/m(2 respectively and Asian Indian (23, 25 kg/m(2 populations. The objective of this study was to develop BMI cut-offs for thinness, overweight, and obesity for South Asian children in the Netherlands, and to compare the BMI cut-offs and distribution with an Asian Indian reference, the WHO Child Growth Reference, and universal BMI cut-offs. METHODS: A reference cohort of 546 Surinamese South Asian boys and 521 girls, born between 1974-1976 (during the pre-obesity era with 3408 and 3267 BMI measurements respectively, was retrospectively analysed. BMI-for-age charts were created with the LMS method. BMI centile curves passing through the cut-off points of 15 (thinness, 23 (overweight, 25 and 27.5 kg/m(2 (obesity at 18y were drawn as cut-off levels. RESULTS: The BMI of Surinamese South Asian children had a similar distribution to the Asian Indian reference, apart from a lower mean and less variation. The BMI distribution differed considerably from the WHO reference and universal BMI criteria. The calculated BMI cut-offs corresponding to a BMI of 15, 23, 25, and 27.5 kg/m(2 at 18y were at the 7.1, 81.1, 89.8, and 95.5 percentile respectively in boys, and at the 2.7, 79.5, 89.2, and 95.2 percentile in girls. CONCLUSIONS: This is the first study proposing BMI cut-offs for South Asian children based on measurements from a prosperous population unaffected by the obesity epidemic. We recommend the use of these cut-offs in South Asian children in the Netherlands as these better reflect the health risks associated with thinness, overweight and obesity, and therefore may prevent the development of cardiometabolic disorders.

  10. High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis

    Aldo Spadaro; Antonino Ajello; Oscar Ferraù; Maria Antonietta Freni; Vincenza Tortorella; Carmela Morce; Agostino Fortiguerra; Paola Composto; Caterina Bonfiglio; Angela Alibrandi; Carmelo Luigiano; Giuseppe De Caro

    2008-01-01

    AIM:To measure plasma D-dimer levels in cirrhotic patients with and without ascites,assessing the effect of ascites resolution in D-dimer concentration.METHODS:Seventy consecutive cirrhotic patients(M=44,F=26,mean age 65 years,SD±13),observed from OdDber 2005 to March 2006 were enrolled.Circulating D-dimer Ievels were measured using a latex-enhanced,immunoturbidimetric test.In patients with ascites(,7=42)the test was repeated after ascites resolution.RESULTS:Ascites was present in 42 patients(group A)and absent in 28(group B).Group A patients had more advanced Iiver disease.Hepatocellular carcinoma(HCC)was diagnosed in 14 patients and was more frequent in group B.Above normaI range D-dimers were found in 45/70 patients.High D-dimers were more frequent in group A than in group B(P=0.001).High D-dimers were associated with presence of HCC(P=0.048)only in group B.Afber ascites resolution,obtained in all patienIs,mean D-dimer values decreased in those 34 patients with high basal levels(P=0.007),returning to normal in 17.CONCLUSION:In patients with Iiver cirrhosis,ascites and HCC are the main factors associated with increased fibrinolytic activiby.

  11. Distributions of the S-matrix poles in Woods-Saxon and cut-off Woods-Saxon potentials

    Salamon, P.; Baran, Á.; Vertse, T.

    2016-08-01

    The positions of the l = 0S-matrix poles are calculated in generalized Woods-Saxon (GWS) potential and in cut-off generalized Woods-Saxon (CGWS) potential. The solutions of the radial equations are calculated numerically for the CGWS potential and analytically for GWS using the formalism of Gy. Bencze [1]. We calculate CGWS and GWS cases at small non-zero values of the diffuseness in order to approach the square well potential and to be able to separate effects of the radius parameter and the cut-off radius parameter. In the case of the GWS potential the wave functions are reflected at the nuclear radius therefore the distances of the resonant poles depend on the radius parameter of the potential. In CGWS potential the wave function can be reflected at larger distance where the potential is cut to zero and the derivative of the potential does not exist. The positions of most of the resonant poles do depend strongly on the cut-off radius of the potential, which is an unphysical parameter. Only the positions of the few narrow resonances in potentials with barrier are not sensitive to the cut-off distance. For the broad resonances the effect of the cut-off cannot be corrected by using a suggested analytical form of the first order perturbation correction.

  12. oA novel nonparametric approach for estimating cut-offs in continuous risk indicators with application to diabetes epidemiology

    Ferger Dietmar

    2009-09-01

    Full Text Available Abstract Background Epidemiological and clinical studies, often including anthropometric measures, have established obesity as a major risk factor for the development of type 2 diabetes. Appropriate cut-off values for anthropometric parameters are necessary for prediction or decision purposes. The cut-off corresponding to the Youden-Index is often applied in epidemiology and biomedical literature for dichotomizing a continuous risk indicator. Methods Using data from a representative large multistage longitudinal epidemiological study in a primary care setting in Germany, this paper explores a novel approach for estimating optimal cut-offs of anthropomorphic parameters for predicting type 2 diabetes based on a discontinuity of a regression function in a nonparametric regression framework. Results The resulting cut-off corresponded to values obtained by the Youden Index (maximum of the sum of sensitivity and specificity, minus one, often considered the optimal cut-off in epidemiological and biomedical research. The nonparametric regression based estimator was compared to results obtained by the established methods of the Receiver Operating Characteristic plot in various simulation scenarios and based on bias and root mean square error, yielded excellent finite sample properties. Conclusion It is thus recommended that this nonparametric regression approach be considered as valuable alternative when a continuous indicator has to be dichotomized at the Youden Index for prediction or decision purposes.

  13. Screening for pulmonary embolism with a D-dimer assay: do we still need to assess clinical probability as well?

    Hammond, Christopher J; Hassan, Tajek B.

    2005-01-01

    Clinical risk stratification and D-dimer assay can be of use in excluding pulmonary embolism in patients presenting to emergency departments but many D-dimer assays exist and their accuracy varies. We used clinical risk stratification combined with a quantitative latex-agglutination D-dimer assay to screen patients before arranging further imaging if required. Retrospective analysis of a sequential series of 376 patients revealed that no patient with a D-dimer of

  14. Dynamical behavior and cut-off frequency of Si/SiGe microcoolers

    Ezzahri, Y.; Dilhaire, S.; Patiño-Lopez, L. D.; Grauby, S.; Claeys, W.; Bian, Z.; Zhang, Y.; Shakouri, A.

    2007-01-01

    Solid-state microcoolers offer an attractive way to solve some of the problems related to temperature stabilisation and control, not only in optoelectronic and microelectronic applications, but also in biological applications where specimens require cooling. One of the important parameters of these coolers is their transient response or their cut-off frequency. We studied how this parameter is influenced by material properties (e.g., substrate and superlattice layer thermal diffusivities), and by geometrical factors (e.g., microcooler cross sectional area or thickness). Our models are based on a modified Thermal Quadrupole Method, which only takes the Peltier effect into account; the reason behind the modification is that the Peltier and Joule effects are uncorrelated in the frequency domain, so their contributions can be studied separately. The thermophysical properties of the microcooler are assumed to be temperature independent. The effect of the top side heat leakage on the performance of the microcooler is also presented.

  15. Percentile curves for body fatness and cut-offs to define malnutrition in Russians

    Nikolaev, D. V.; Rudnev, S. G.; Starunova, O. A.; Eryukova, T. A.; Kolesnikov, V. A.; Ponomareva, E. G.; Soboleva, N. P.; Sterlikov, S. A.

    2013-04-01

    Here, we report first results of the large-scale ongoing bioelectrical impedance body composition study in Russians. By the end of 2012, 216 out of 800 Russian Health Centres submitted raw bioimpedance data on 844,221 adults and children aged 5-80 years, representing nearly 0.6% of the Russian population, who were accessed cross-sectionally using the same type of bioimpedance meter, ABC-01 Medas. Estimates of overweight, obesity, and normal weight obesity prevalence in the general population, as well as characteristics of diagnostic sensitivity and specificity of the conventional WHO BMI-based criteria of obesity depending on age are obtained. The smoothed reference centile curves for percentage fat mass are constructed, and localized cut-offs for fatness and thinness are provided that can be used both at the individual and epidemiological levels.

  16. Percentile curves for body fatness and cut-offs to define malnutrition in Russians

    Here, we report first results of the large-scale ongoing bioelectrical impedance body composition study in Russians. By the end of 2012, 216 out of 800 Russian Health Centres submitted raw bioimpedance data on 844,221 adults and children aged 5–80 years, representing nearly 0.6% of the Russian population, who were accessed cross-sectionally using the same type of bioimpedance meter, ABC-01 Medas. Estimates of overweight, obesity, and normal weight obesity prevalence in the general population, as well as characteristics of diagnostic sensitivity and specificity of the conventional WHO BMI-based criteria of obesity depending on age are obtained. The smoothed reference centile curves for percentage fat mass are constructed, and localized cut-offs for fatness and thinness are provided that can be used both at the individual and epidemiological levels.

  17. The Association Between Epicardial Adipose Tissue and Coronary Artery Disease: an Echocardiographic Cut-off Point

    Mehrnoush Toufan

    2012-09-01

    Full Text Available Introduction: EAT is an independent factor in coronary artery disease (CAD. The objective of the current study was to define an echocardiographic cut-off point for EAT and to determine its diagnostic value in predicting the increase in CAD risk. Methods: Two hundred patients underwent coronary artery angiography for diagnosis of CAD and transthoracic echocardiography for measurement of EAT on the right ventricle (RV, RV apex and RV outlet tract. Sensitivity, specificity, positive predictive value (PPV and negative predictive value (NPV of the EAT cut-off points in the three above-mentioned areas for predicting the severity of CAD were measured. The relation between the EAT and CAD risk factors was evaluated as well. Results: EAT was independent from gender, height, hypertension, diabetes, HDL, total cholesterol, ejection fraction, acute coronary syndrome, and the location of the coronary artery stenosis in the coronary artery in all three anatomical areas. EAT on RV and RV apex had a significant relation with CAD (P ≤ 0.05. Overall, RV EAT≥ 10 mm and RV apex EAT ≥ 8 mm had sensitivity and PPV of more than 70% in predicting coronary stenosis ≥ 50% and acute coronary syndrome (ACS and RVOT EAT ≥ 13 mm is of PPV=83.5% for predicting coronary stenosis ≥ 50%. Conclusion: EAT thickness has an acceptable diagnostic value for predicting severe coronary artery stenosis and ACS. Therefore, non-invasive EAT thickness measurement could be of great assistance to clinicians for detecting the patients at risk and helping them to undergo supplementary evaluations with invasive approaches.

  18. Role of neutron and proton system in spin cut off parameter and entropy of {sup 89,90}Y

    Rahmatinejad, A. [Department of Physics, Faculty of Science, University of Zanjan, Zanjan (Iran, Islamic Republic of); Razavi, R., E-mail: rrazavin@ihu.ac.ir [Physics Department, Faculty of Science, Imam Hossein Comprehensive University, Tehran (Iran, Islamic Republic of); Kakavand, T. [Department of Physics, Faculty of Science, Imam Khomeini International University, Qazvin (Iran, Islamic Republic of)

    2015-09-15

    The nuclear level densities, entropies and spin cut off parameters have been determined in {sup 89,90}Y nuclei using the BCS model with inclusion of pairing interaction. The results have a good agreement with the recent experimental data on the level densities measured by the Oslo group. In addition, the entropy excess of {sup 90}Y compared to {sup 89}Y as a function of temperature has been extracted. Also, the role of neutron and proton systems in the entropy excess as well as the spin cut off excess have been investigated using the entropy excess ratio and spin cut off excess ratio introduced in our previous publication. The role of the neutron system at low temperatures, the temperatures below critical temperature, in the semi-magic nucleus {sup 89}Y is similar compared to the closed shell proton system in the tin isotopes.

  19. Fixed Cut-Off for FEV1/FEV6 and FEV6 in Detection of Obstructive and Restrictive Patterns

    Aghili, Rokhsareh; Kia, Maryam; Meysamie, Alipasha; Aghili, Seyed Mojtaba; Paknejad, Omalbanin

    2013-01-01

    Background Chronic obstructive pulmonary diseases (COPD) have been defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) as irreversible conditions which are diagnosed by fixed cut-off points of FEV1/FVC. Objective The aim of this study was to determine the cut-off points for FEV1/FEV6 ratio and FEV6 as alternatives for FEV1/FVC and FVC in detection of airway obstruction and lung restriction, respectively. Materials and Methods A total of 318 Spiro metric examinations o...

  20. Shear avalanches in metallic glasses under nanoindentation: Deformation units and rate dependent strain burst cut-off

    Indented metallic glasses at the nanoscale deform via strain bursts. Conventional continuum descriptions are not appropriate for such highly stochastic, intermittent deformations. In this study, after a statistical analysis of strain bursts in five metallic glasses, the dependence of the cut-off of the strain burst size on deformation units and loading rate is established. For soft metallic glasses with smaller deformation units, cut-off of the strain burst size truncates the scale-free behavior at larger strain burst sizes. For hard metallic glasses, scale-free behavior occurs in a wide range of strain burst sizes

  1. Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis*

    Criado, Paulo Ricardo; Antinori, Lidi Che Leon; Maruta, Celina Wakisaka; dos Reis, Vitor Manoel Silva

    2013-01-01

    BACKGROUND It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with disease a...

  2. Capnometry in suspected pulmonary embolism with positive D-dimer in the field

    Rumpf, Tadeja Hernja; Križmarić, Miljenko; Grmec, Štefek

    2009-01-01

    Introduction Pulmonary embolism (PE) is one of the greatest diagnostic challenges in prehospital emergency setting. Most patients with suspected PE have a positive D-dimer and undergo diagnostic testing. Excluding PE with additional non-invasive tests would reduce the need for further imaging tests. We aimed to determine the effectiveness of combination of clinical probability and end-tidal carbon dioxide (PetCO2) for evaluation of suspected PE with abnormal concentrations of D-dimer in preho...

  3. Kadar Fibrinogen Dan D-Dimer Pada Wanita Dengan Sindroma Ovarium Polikistik

    Lubis, Hilma Putri

    2015-01-01

    BACKGROUND : Polycystic Ovarian Syndrome (PCOS) is a dysfunction of ovarium with polycystic ovarian morphology and hiperandrogenism state. Fibrinogen dan D-dimer are hemostatic factors. Fibrinogen considered as an independent risk factor for cardiovascular disease. D-dimer, final product of cross-linked fibrin degeneration by plasmin in fibrinolytic system, also contributes to cardiovascular and miscarriage risk especially in PCOS patient. OBJECTIVE : To find the difference of fibrinogen a...

  4. Cut-off Characterisation of Energy Spectra of Bright Fermi Sources: Current instrument limits and future possibilities

    Romoli, C; Aharonian, F

    2016-01-01

    In this paper some of the brightest GeV sources observed by the Fermi-LAT were analysed, focusing on their spectral cut-off region. The sources chosen for this investigation were the brightest blazar flares of 3C 454.3 and 3C 279 and the Vela pulsar using catalogue data and reanalysis with the latest Fermi-LAT software. For the study the spectral cut-off we first explored the Vela pulsar spectrum, whose statistics in the 3FGL catalog allowed strong constraints to be obtained on the parameters. We subsequently performed a new analysis of the flaring blazar SEDs. For these sources we obtained constraints on the cut-off parameters under the assumption that their underlying spectral distribution is described by a power-law with a stretched exponential cut-off. We then highlighted the significant potential improvements on such constraints by observations with next generation ground based Cherenkov telescopes, represented in our study by the Cherenkov Telescope Array (CTA). Adopting currently available simulations ...

  5. Appropriate body mass index cut-offs to determine thinness, overweight and obesity in South Asian children in The Netherlands

    Wilde, J.A. de; Dommelen, P. van; Middelkoop, B.J.C.

    2013-01-01

    Background: Asian populations have an increased risk of developing cardiometabolic disorders at a lower body mass index (BMI) than other ethnic groups. Therefore, lower adult BMI cut-offs to determine overweight and obesity are recommended to assess the associated health risks for Asian (23 and 27.5

  6. Design and construction of a soil bentonite cut-off wall for Suncor's South Tailings Pond

    Stephens, B. [Klohn Crippen Berger Ltd., Calgary, AB (Canada); Bowron, M. [Suncor Energy Inc., Fort McMurray, AB (Canada)

    2010-07-01

    Commissioned in July 2006, Suncor's South Tailings Pond (STP) is an external oil sands tailings storage facility with a footprint of 2300 hectares including infrastructure. The Southwest cut-off wall was completed in 2008, forming one of four principal seepage management systems for the STP. The cut-off wall consists of soil bentonite backfill from native materials from the wall excavation. Construction of the wall utilized both a long-stick back-hoe and crane mounted clamshell to excavate the wall under bentonite slurry. This paper discussed the construction of the cut-off wall as well as the the field and laboratory testing programs that determined the soil-bentonite mix. It also described the quality assurance and quality control programs conducted during construction. Last, the paper provided a brief discussion of the design and construction issues specific to seepage cut-off walls in the oil sands region. It was concluded that while construction of a soil-bentonite wall is a simple process, a professional experienced in the construction of deep walls is essential to achieve a quality product. Technical site support is also needed by the construction team in order to confirm geology, material properties and design assumptions. 1 tab., 5 figs.

  7. Qualitative D-Dimer in deep vein thrombosis: A single center prospective study from Kashmir India

    Davinder Pal Singh

    2012-01-01

    Full Text Available Objective: The aim of our study was to study the significance of qualitative D-dimer in the diagnosis of deep vein thrombosis. Study Design: Prospective analysis. Setting: Tertiary care hospital. Materials and Methods: One hundred and twenty nine patients of suspected deep vein thrombosis were included in the study and further categorized as likely or unlikely to have deep vein thrombosis on Wells scoring system. The patients in both the likely and unlikely categories were then randomly assigned to undergo D-dimer testing (D-dimer group or to undergo ultrasound imaging alone (control group. The patients with pre text clinical probability score as unlikely and with negative D-dimer test were considered not to have DVT. The primary event was recurrent venous thromboembolism in both the groups during three months of follow-up. Results: A total of one hundred and twenty nine patients with suspected DVT were included in the study. Sixty five patients were randomly assigned to D-dimer group and sixty four to the doppler group. The diagnosis of DVT was established in 41 (31.78% patients. Among patients in whom DVT was ruled out by the initial diagnostic evaluation one case of deep vein thrombosis was confirmed in the D-dimer group (1/55, 1.8%; 95% confidence interval, 1.6 to 5.2% and two cases in the Doppler group (2/51, 3.92%; 95% confidence interval, 1.5 to 9.34% during three months of follow-up. The use of D-dimer resulted in lesser number of USG (0.66 tests per person in the D-dimer group as compared to (1.23 tests per person in the Doppler group. Forty patients (31% in the D-dimer group did not require ultrasound imaging. Conclusion: The diagnostic performance of qualitative D-dimer assay combined with a clinical pre text probability score can also rule out DVT safely in low probability scores without significantly compromising safety.

  8. ELISA Cut-off Point for the Diagnosis of Human Brucellosis; a Comparison with Serum Agglutination Test

    Anahita Sanaei Dashti

    2012-03-01

    Full Text Available Background: Brucellosis is a world-wide disease, which has a diverse clinical manifestation, and its diagnosis has to be proven by laboratory data. Serum agglutination test (SAT is the most-widely used test for diagnosing brucellosis. The enzyme linked immunosorbent assay (ELISA can also determine specific antibody classes against brucella. It is a sensitive, simple and rapid test, which could be an acceptable alternative to SAT with fewer limitations, however, like any other new test it should be further evaluated and standardized for various populations. This study was planned to determine an optimal cut-off point, for ELISA which would offer maximum sensitivity and specificity for the test when compared to SAT.Methods: Four hundred and seven patients with fever and other compatible symptoms of brucellosis were enrolled in the study. Serum agglutination test, 2-Mercaptoethanol test, and ELISA were performed on their sera. Results: The cut-off point of 53 IU/ml of ELISA-IgG yielded the maximal sensitivity and specificity comparing to the other levels of ELISA-IgG, and was considered the best cut off-point of ELISA-IgG to diagnose acute brucellosis. At this cut-off, the sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio were 84.09%, 85.38%, 62.20, 94.90, 5.75, 0.18, respectively.Conclusion: The best cut-off point of ELISA-IgG is 53 IU/ml, which yields the maximal sensitivity and specificity to diagnose acute brucellosis.

  9. Mechanically robust 39 GHz cut-off frequency graphene field effect transistors on flexible substrates.

    Wei, Wei; Pallecchi, Emiliano; Haque, Samiul; Borini, Stefano; Avramovic, Vanessa; Centeno, Alba; Amaia, Zurutuza; Happy, Henri

    2016-08-01

    Graphene has been regarded as a promising candidate channel material for flexible devices operating at radio-frequency (RF). In this work we fabricated and fully characterized double bottom-gate graphene field effect transistors on flexible polymer substrates for high frequency applications. We report a record high as-measured current gain cut-off frequency (ft) of 39 GHz. The corresponding maximum oscillation frequency (fmax) is 13.5 GHz. These state of the art high frequency performances are stable against bending, with a typical variation of around 10%, for a bending radius of up to 12 mm. To demonstrate the reliability of our devices, we performed a fatigue stress test for RF-GFETs which were dynamically bend tested 1000 times at 1 Hz. The devices are mechanically robust, and performances are stable with typical variations of 15%. Finally we investigate thermal dissipation, which is a critical parameter for flexible electronics. We show that at the optimum polarization the normalized power dissipated by the GFETs is about 0.35 mW μm(-2) and that the substrate temperature is around 200 degree centigrade. At a higher power, irreversible degradations of the performances are observed. Our study on state of the art flexible GFETs demonstrates mechanical robustness and stability upon heating, two important elements to assess the potential of GFETs for flexible electronics. PMID:27396243

  10. Susceptibility profile and epidemiological cut-off values of Cryptococcus neoformans species complex from Argentina.

    Córdoba, Susana; Isla, Maria G; Szusz, Wanda; Vivot, Walter; Altamirano, Rodrigo; Davel, Graciela

    2016-06-01

    Epidemiological cut-off values (ECVs) based on minimal inhibitory concentration (MIC) distribution have been recently proposed for some antifungal drug/Cryptococcus neoformans combinations. However, these ECVs vary according to the species studied, being serotypes and the geographical origin of strains, variables to be considered. The aims were to define the wild-type (WT) population of the C. neoformans species complex (C. neoformans) isolated from patients living in Argentina, and to propose ECVs for six antifungal drugs. A total of 707 unique C. neoformans isolates obtained from HIV patients suffering cryptococcal meningitis were studied. The MIC of amphotericin B, flucytosine, fluconazole, itraconazole, voriconazole and posaconazole was determined according to the EDef 7.2 (EUCAST) reference document. The MIC distribution, MIC50 , MIC90 and ECV for each of these drugs were calculated. The highest ECV, which included ≥95% of the WT population modelled, was observed for flucytosine and fluconazole (32 μg ml(-1) each). For amphotericin B, itraconazole, voriconazole and posaconazole, the ECVs were: 0.5, 0.5, 0.5 and 0.06 μg ml(-1) respectively. The ECVs determined in this study may aid in identifying the C. neoformans strains circulating in Argentina with decreased susceptibility to the antifungal drugs tested. PMID:26865081

  11. FACTORS AFFECTING THE HYDRAULIC BARRIER PERFORMANCE OF SOIL-BENTONITE MIXTURE CUT-OFF WALL

    Takai, Atsushi; Inui, Toru; Katsumi, Takeshi; Kamon, Masashi; Araki, Susumu

    Containment technique using cut-off walls is a valid method against contaminants in subsurface soil and/or groundwater. This paper states laboratory testing results on hydraulic barrier performance of Soil-Bentonite (SB), which is made by mixing bentonite with in-situ soil. Since the bentonite swelling is sensitive to chemicals, chemical compatibility is important for the hydraulic barrier performance of SB. Hydraulic conductivity tests using flexible-wall permeameter were conducted on SB specimens with various types and concentrations of chemicals in the pore water and/or in the permeant and with various bentonite powder contents. As a result, hydraulic barrier performance of SB was influenced by the chemical concentration in the pore water of original soil and bentonite powder content. In the case that SB specimens have damage parallel to the permeating direction, no significant leakage in the SB occurs by the self-sealing property of SB. In addition, the hydraulic conductivity values of SB have excellent correlation with their plastic indexes and swelling pr essures, thus these properties of SB have some possibility to be indicators for estimation of the hydraulic barrier performance of SB.

  12. Higher-spin realization of a dS static patch/cut-off CFT correspondence

    Karch, Andreas

    2013-01-01

    We derive a holographic relation for the dS static patch with the dual field theory defined on the observer horizon. The starting point is the duality of higher-spin theory on AdS_4 and the O(N) vector model. We build on a similar analytic continuation as used recently to obtain a realization of dS/CFT, and adapt it to the static patch. The resulting duality relates higher-spin theory on the dS_4 static patch to a cut-off CFT on the cylinder RxS^2. The construction permits a derivation of the finite thermodynamic entropy associated to the horizon of the static patch from the dual field theory. As a further brick we recover the spectrum of quasinormal frequencies from the correlation functions of the boundary theory. In the last part we incorporate the dS/dS correspondence as an independent proposal for holography on dS and show that a concrete realization can be obtained by similar reasoning.

  13. Detection of cut-off point for rapid automized naming test in good readers and dyslexics

    Zahra Soleymani

    2014-01-01

    Full Text Available Background and Aim: Rapid automized naming test is an appropriate tool to diagnose learning disability even before teaching reading. This study aimed to detect the cut-off point of this test for good readers and dyslexics.Methods: The test has 4 parts including: objects, colors, numbers and letters. 5 items are repeated on cards randomly for 10 times. Children were asked to name items rapidly. We studied 18 dyslexic students and 18 age-matched good readers between 7 and 8 years of age at second and third grades of elementary school; they were recruited by non-randomize sampling into 2 groups: children with developmental dyslexia from learning disabilities centers with mean age of 100 months, and normal children with mean age of 107 months from general schools in Tehran. Good readers selected from the same class of dyslexics.Results: The area under the receiver operating characteristic curve was 0.849 for letter naming, 0.892 for color naming, 0.971 for number naming, 0.887 for picture naming, and 0.965 totally. The overall sensitivity and specificity was 1 and was 0.79, respectively. The highest sensitivity and specificity were related to number naming (1 and 0.90, respectively.Conclusion: Findings showed that the rapid automized naming test could diagnose good readers from dyslexics appropriately.

  14. Solute removal capacity of high cut-off membrane plasma separators.

    Ohkubo, Atsushi; Kurashima, Naoki; Nakamura, Ayako; Miyamoto, Satoko; Iimori, Soichiro; Rai, Tatemitsu

    2013-10-01

    In vitro blood filtration was performed by a closed circuit using high cut-off membrane plasma separators, EVACURE EC-2A10 (EC-2A) and EVACURE EC-4A10 (EC-4A). Samples were obtained from sampling sites before the plasma separator, after each plasma separator, and from the ultrafiltrate of each separator. The sieving coefficient (S.C.) of total protein (TP), albumin (Alb), IgG, interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), fibrinogen (Fib), antithrombin III (AT-III), and coagulation factor XIII (FXIII) were calculated. The S.C. of each solute using EC-2A and EC-A4 were as follows; TP: 0.25 and 0.56, Alb: 0.32 and 0.73, IgG: 0.16 and 0.50, IL-6:0.73 and 0.95, IL-8:0.85 and 0.82, TNF-α: 1.07 and 0.99, Fib: 0 and 0, FXIII: 0.07 and 0.17, respectively. When compared with the conventional type of membrane plasma separators, EVACURE could efficiently remove cytokines while retaining coagulation factors such as fibrinogen. Moreover, EC-2A prevented protein loss, whereas EC-4A could remove approximately 50% of IgG. PMID:24107276

  15. Dynamics of magnetostatic wave solitons in the vicinity of frequency cut-off

    Nonlinear dynamics of one-dimensional pulses of exchangeless backward volume magnetostatic waves propagating in thin ferrite films with a thickness 2l=(3-10) μm is studied numerically. The Whitham's approach of taking into account the exact wave dispersion is utilized. It has been found that in the case of small wave numbers (0.020l≤0.05), even under a validity of quasi-stationary approximation, a commonly used polynomial approximation for the wave dispersion gives only rough description for nonlinear pulse dynamics. The reason is a presence of cut-off at higher frequencies. For greater wave numbers (k0l≥0.1), the nonlinear wave dynamics coincides with results obtained earlier in the parabolic approximation for the wave dispersion. Two-dimensional dynamics of nonlinear pulses is also investigated briefly in the full dispersion approach. The collapse-like phenomena have been found there when the central wave number is chosen as k0l≥0.04

  16. Immunity status against poliomyelitis in Germany: Determination of cut-off values in International Units

    Schreier Eckart

    2002-02-01

    Full Text Available Abstract Background To prevent importations of wild polioviruses into a polio free region a high level of population immunity must be kept. Standard methodology for determination of polio antibodies is a feature aimed at obtaining consistent results. An International Standard Serum for polio antibodies exists, but no protective level in International Units is defined. Methods A representative study was carried out in order to determine the serological status against poliomyelitis in Germany (n = 2564, age 18–79 years. Furthermore, sera from persons aged less than 18 years were included (n = 881. Microneutralization test has been used for determination of antibody levels. Results have been expressed in International Units. Results The results of this study indicate that the cut-off level for polio antibodies is 0.075 IU/ml for Polio 1, 0.180 IU/ml for Polio 2 and 0.080 IU/ml for Polio 3. Neutralizing antibodies against poliovirus type 1, 2 and 3 were detected in 96.2%, 96.8% and 89.6% of samples, respectively. Conclusions Overall, this seroprevalence indicates a very high level of immunity of the general population. It must be kept after the switch of immunization strategy from attenuated to inactivated vaccine in Germany.

  17. Activation of coagulation system and d-dimer levels in children with acute leukemia

    Harun Wijaya

    2014-07-01

    Full Text Available Background D-dimer is a molecule as result of breaking down of excessive fibrin formation from the activation of coagulation system. There is evidence of increased activation of coagulation in patients with acute leukemia which was showed by the increment of d-dimer levels. Objective To evaluate the incidence of activation of coagulation system in children with acute leukemia before receiving chemotherapy. Method This cross-sectional study was performed at Dr. Cipto Mangunkusumo Hospital. All newly-diagnosed children with acute leukemia were included in this study, prior to their receiving any chemotherapy treatment. Blast count, prothrombin time (PTT, activated partial thromboplastin time (APTT, and D-dimer levels were examined after the diagnosis was confirmed by morphology and immunophenotyping studies on bone marrow specimens. Results Out of 22 subjects, 13 subjects had increased D-dimer values. The median D-dimer level of this elevated group was 1,000 (range 500-14,700 ng/mL. In the acute myeloblastic leukemia (AML patients, activation of coagulation was found in 7 out of 8 subjects. The median D-dimer levels was 950 (range 100-14,700 ng/mL. In the acute lymphocytic leukemia (ALL patients, 6 out of 14 subjects had increased activation of coagulation with median D-dimer level of 300 (range 100-3,800 ng/mL. Nine out of 10 subjects with blast cells on peripheral blood smear had a median D-dimer level of 1,000 (range 500-3,800 ng/mL. Both PT and APTT were found normal in all subjects. Conclusion Activation of coagulation system occurs at the time of diagnosis as shown by increased D-dimer levels. The characteristics of activation of coagulation system are different between ALL and AML subjects, as well as between subjects with positive and negative blast counts on peripheral blood smears. Despite the increased activation of coagulation, PT and APTT remain normal. [Paediatr Indones. 2014;54:227-31.].

  18. The Objective Borderline Method (OBM): A Probability-Based Model for Setting up an Objective Pass/Fail Cut-Off Score in Medical Programme Assessments

    Shulruf, Boaz; Turner, Rolf; Poole, Phillippa; Wilkinson, Tim

    2013-01-01

    The decision to pass or fail a medical student is a "high stakes" one. The aim of this study is to introduce and demonstrate the feasibility and practicality of a new objective standard-setting method for determining the pass/fail cut-off score from borderline grades. Three methods for setting up pass/fail cut-off scores were compared: the…

  19. CT Findings of Disease with Elevated Serum D-Dimer Levels in an Emergency Room Setting

    Choi, Ji Youn; Kwon, Woo Cheol; Kim, Young Ju [Dept. of Radiology, Wonju Christian Hospital, Yensei University Wonju College of Medicine, Wonju (Korea, Republic of)

    2012-01-15

    Pulmonary embolism and deep vein thrombosis are the leading causes of elevated serum D-dimer levels in the emergency room. Although D-dimer is a useful screening test because of its high sensitivity and negative predictive value, it has a low specificity. In addition, D-dimer can be elevated in various diseases. Therefore, information on the various diseases with elevated D-dimer levels and their radiologic findings may allow for accurate diagnosis and proper management. Herein, we report the CT findings of various diseases with elevated D-dimer levels in an emergency room setting, including an intravascular contrast filling defect with associated findings in a venous thromboembolism, fracture with soft tissue swelling and hematoma formation in a trauma patient, enlargement with contrast enhancement in the infected organ of a patient, coronary artery stenosis with a perfusion defect of the myocardium in a patient with acute myocardial infarction, high density of acute thrombus in a cerebral vessel with a low density of affected brain parenchyma in an acute cerebral infarction, intimal flap with two separated lumens in a case of aortic dissection, organ involvement of malignancy in a cancer patient, and atrophy of a liver with a dilated portal vein and associated findings.

  20. Mechanically robust 39 GHz cut-off frequency graphene field effect transistors on flexible substrates

    Wei, Wei; Pallecchi, Emiliano; Haque, Samiul; Borini, Stefano; Avramovic, Vanessa; Centeno, Alba; Amaia, Zurutuza; Happy, Henri

    2016-07-01

    Graphene has been regarded as a promising candidate channel material for flexible devices operating at radio-frequency (RF). In this work we fabricated and fully characterized double bottom-gate graphene field effect transistors on flexible polymer substrates for high frequency applications. We report a record high as-measured current gain cut-off frequency (ft) of 39 GHz. The corresponding maximum oscillation frequency (fmax) is 13.5 GHz. These state of the art high frequency performances are stable against bending, with a typical variation of around 10%, for a bending radius of up to 12 mm. To demonstrate the reliability of our devices, we performed a fatigue stress test for RF-GFETs which were dynamically bend tested 1000 times at 1 Hz. The devices are mechanically robust, and performances are stable with typical variations of 15%. Finally we investigate thermal dissipation, which is a critical parameter for flexible electronics. We show that at the optimum polarization the normalized power dissipated by the GFETs is about 0.35 mW μm-2 and that the substrate temperature is around 200 degree centigrade. At a higher power, irreversible degradations of the performances are observed. Our study on state of the art flexible GFETs demonstrates mechanical robustness and stability upon heating, two important elements to assess the potential of GFETs for flexible electronics.Graphene has been regarded as a promising candidate channel material for flexible devices operating at radio-frequency (RF). In this work we fabricated and fully characterized double bottom-gate graphene field effect transistors on flexible polymer substrates for high frequency applications. We report a record high as-measured current gain cut-off frequency (ft) of 39 GHz. The corresponding maximum oscillation frequency (fmax) is 13.5 GHz. These state of the art high frequency performances are stable against bending, with a typical variation of around 10%, for a bending radius of up to 12 mm. To

  1. Potential interface slip analysis of Peribonka Dam plastic concrete cut-off wall

    Morency, J.Y.; Chahde, J.; Bigras, A. [Hydro-Quebec, Montreal, PQ (Canada); Garand, P.; Rattue, A. [SNC-Lavalin Inc., Montreal, PQ (Canada)

    2006-07-01

    The Peribonka hydroelectric development is currently under construction near the confluence of the Manouane River with the Peribonka River in Quebec. It includes an 80 m high dam and two dykes of zoned earth fills with a till core, an underground power house with an installed capacity of 385 MW, a diversion tunnel and a spillway. The Peribonka dam will be built on a highly permeable alluvial foundation. The design includes a 10 m high working platform in the river between the cofferdams and a plastic concrete cut-off wall (COW) down to bedrock. The maximum depth of the COW in a narrow canyon will be 115 m. A bi-dimensional finite element stress and deformation analysis software (SDAS) was used to model the stress-strain behaviour of the foundation soils and the COW under the dam. The SDAS software made it possible to determine the vertical deformations as well as the horizontal stress distribution in the foundation soils. It was shown that due to the oedometric nature of the loading of the soil, no significant shear stress was generated due to the soil deformations in the foundation below the axis of the dam. However, the finite element program did not allow hyperbolic model slip elements. As such, it was not possible to evaluate if negative skin friction occurred at the soilplastic concrete interface. For that reason, a one-dimensional model allowing the simulation of negative or positive friction between the soil and the COW was developed. This model considered the elastic-plastic behaviour of the COW using a hyperbolic model. It showed that nowhere, except in the upper 2 to 3 m of the COW embedment in the core, was negative friction able to mobilize the full value of the internal friction angle of the soil. 4 refs., 1 tab., 9 figs.

  2. Elevation in D-dimer concentrations is positively correlated with gestation in normal uncomplicated pregnancy

    Jeremiah ZA

    2012-08-01

    Full Text Available Zaccheaus A Jeremiah,1 Teddy C Adias,2 Margaret Opiah,3 Siyeoforiye P George,4 Osaro Mgbere,5 Ekere J Essien61Department of Medical Laboratory Sciences, Niger Delta University, Wilberforce Island, Nigeria; 2Bayelsa State College of Health Technology, Ogbia-Town, Nigeria; 3Department of Maternal and Child Health, Faculty of Nursing, Niger Delta University, Wilberforce Island, Nigeria; 4Postgraduate Hematology Unit, Rivers State University of Science and Technology, Port Harcourt, Nigeria; 5Houston Department of Health and Human Services, Houston, TX, USA; 6Institute of Community Health, University of Houston, Houston, TX, USABackground: D-dimer levels have been reported to increase progressively during pregnancy, but how this affects Nigerian women is not well known.Objective: This study aims to determine the D-dimer concentration and its relationship to other coagulation parameters among pregnant women in Port Harcourt, Nigeria.Method: In a cross-sectional observational study conducted in Port Harcourt, Nigeria, 120 pregnant women and 60 nonpregnant controls, drawn from a tertiary health institution in the Niger Delta, Nigeria, were assessed, using the standard procedures, for the following parameters: D-dimer concentration, prothrombin time, activated partial thromboplastin time, platelet count, hemoglobin, and packed cell volume.Results: The median D-dimer concentration of 153.1 ng/mL in the pregnant group was found to be significantly elevated when compared with the control value of 118.5 ng/mL (t = 2.348, P = 0.021. Conversely, there was a marked depression in the platelet count among pregnant women (193.5 × 109/L when compared with 229.0 × 109/L in the control group (t = 3.424; P = 0.001. There was no statistically significant difference in the values for the prothrombin time and the activated partial thromboplastin time between pregnant and nonpregnant women. D-dimer values correlated positively and significantly with gestation (r = 0

  3. Impact of d-Dimers on the Differential Diagnosis of Acute Chest Pain: Current Aspects Besides the Widely Known

    Hahne, Kathrin; Lebiedz, Pia; Breuckmann, Frank

    2014-01-01

    d-dimers are cleavage products of fibrin that occur during plasmin-mediated fibrinolysis of blood clots. In the emergency department, d-dimer measurement represents a valuable and cost-effective tool in the differential diagnosis of acute chest pain including the main life-threatening entities: acute coronary syndrome, pulmonary embolism, and acute aortic syndrome. Whereas the diagnostic and prognostic values of d-dimer testing in acute coronary syndrome is of less priority, increases of d-di...

  4. Interacting logarithmic entropy-corrected holographic dark energy model with different cut-offs in Brans-Dicke cosmology

    Darabi, F

    2015-01-01

    We study the Interacting Logarithmic Entropy-Corrected Holographic Dark Energy model with different cut-offs in Brans-Dicke cosmology and obtain the equation of state and the squared of sound speed for each cut-off. The former is used to describe the accelerating or decelerating behaviour and the later is used to describe the classical stability or instability of the universe. The correspondence between the scalar field models and the logarithmic entropy-corrected holographic dark energy densities allows us to reconstruct the potentials and the dynamics of the quintessence and tachyon scalar field models in Brans-Dicke cosmology. We show that these models can describe the observed accelerated expansion of our universe with a parameter space consistent with the most recent observational data. However, it turns out that there is fine-tuning problem concerning the value of Brans-Dicke parameter $\\omega$ at early universe which casts doubt on the viability of these dark energy models.

  5. Factors in selecting serum samples for use in determining the positive/negative threshold (cut-off) in ELISA

    The threshold (cut-off) that defines whether a test result is seropositive or seronegative is calculated by testing serum samples from a subpopulation of animals that is assumed to represent the target population in all aspects. For this proposition to be true, it is essential to consider the variables in the target population that must be represented in the subpopulation. Without representation of the variables in the subpopulation, it is likely that the cut-off selected for the test will be errant and will misclassify animals as to their infection status. The purpose of this paper is to identify a few of the principal variables that need to be taken into account when selecting a subpopulation of animals for test validation. (author)

  6. ANP, BNP and D-dimer predict right ventricular dysfunction in patients with acute pulmonary embolism

    Borgwardt, Henrik Gutte; Mortensen, Jann; Jensen, Claus V; Von, Der Recke Peter; Petersen, Claus L; Kristoffersen, Ulrik S; Kjær, Andreas

    2010-01-01

    The aim of this study was to predict right ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE).......The aim of this study was to predict right ventricular dysfunction (RVD) using plasma concentration of D-dimer, pro-atrial natriuretic peptide (pro-ANP), brain natriuretic peptide (BNP), endothelin-1 (ET-1) and cardiac troponin I (TNI) in patients with pulmonary embolism (PE)....

  7. Construction and expression of D-dimer and GPIIb/IIIa single-chain bispecific antibody

    DAN, ZHAOKUI; Tan, Zui; Xia, Hongli; WU, GAN

    2013-01-01

    The aim of this study was to construct a plasmid expressing glycoprotein IIb-IIIa (GPIIb/IIIa) and D-dimer single-chain bispecific antibody for the targeted therapy of thrombosis. The phosphorylated gene encoding the anti-GPIIb/IIIa single-chain variable fragment (scFv) and the gene encoding the anti-D-dimer scFv were amplified by PCR and linked in tandem by blunt-end ligation. The recombinant plasmid was transfected into the competent cell line HB2151 and identified by PCR and DNA sequencing...

  8. Cut-Off Scores of the Children's Depression Inventory for Screening and Rating Severity in Korean Adolescents

    Bang, Young Rong; Park, Jae Hong; Kim, Sung Hwan

    2015-01-01

    Objective The aim was to establish an optimal cut-off score of the Children's Depression Inventory (CDI) for detecting depression and rating severity in Korean adolescents. Methods A total of 468 students aged 12-16 years from 8 middle schools in Busan, Korea participated in this study. The Korean version of the CDI and Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version were used to evaluate depressive symptoms. Receiver-operating characteristics (ROC) anal...

  9. On a holographic dark energy model with a Nojiri-Odintsov cut-off in general relativity

    Khurshudyan, M.

    2016-01-01

    In this paper we consider the models of the accelerated expanding large scale universe~(according to general relativity) containing a generalized holographic dark energy with a Nojiri - Odintsov cut - off. The second component of the darkness is assumed to be the pressureless cold dark matter according to observed symmetries of the large scale universe. Moreover, we assume specific forms of the interaction between these two components and besides the cosmographic analysis, we discuss appropri...

  10. Successful use of combined high cut-off haemodialysis and bortezomib for acute kidney injury associated with myeloma cast nephropathy.

    Ward, F

    2012-05-01

    We present the case of a 58-year old female with de novo dialysis-dependent acute kidney injury (AKI) secondary to myeloma cast nephropathy. The patient underwent extended high cut-off haemodialysis (HCO-HD), in conjunction with bortezomib-based chemotherapy, and soon became dialysis independent with normal renal function. To our knowledge, this is the first time this treatment strategy has been employed successfully in an Irish centre.

  11. Dual cut-off dc-tunable microwave low-pass filter on superconducting Nb microstrips with asymmetric nanogrooves

    Dobrovolskiy, Oleksandr V.; Huth, Michael

    2015-01-01

    We present a dual cut-off, dc-tunable low-pass microwave filter on a superconducting Nb microstrip with uniaxial asymmetric nanogrooves. The frequency response of the device was measured in the range $300$\\,KHz to $14$\\,GHz at different temperatures, magnetic fields, and dc current values. The microwave loss is most effectively reduced when the Abrikosov vortex lattice spatially matches the underlying washboard pinning landscape. The forward transmission coefficient $S_{21}(f)$ of the microst...

  12. Cut-Off Value for Pain Sensitivity Questionnaire in Predicting Surgical Success in Patients with Lumbar Disc Herniation

    Azimi, Parisa; Benzel, Edward C.

    2016-01-01

    Various factors related to predict surgical success were studied; however, a standard cut-off point for the Pain Sensitivity Questionnaire (PSQ) measure has not yet been established for a favorable surgical outcome for lumbar disc herniation (LDH). This study was to find the optimal cut-off point on the PSQ to distinguish surgical success in patients with LDH. A total of 154 patients with LDH consecutively referred to our clinic were enrolled into this prospective study between February 2011 and January 2014. All participants completed the PSQ. Patients completed the Oswestry Disability Index (ODI) score before surgery, and at 2 years after surgery. Surgical success was defined as a 13-point improvement from the baseline ODI scores. The cut-off value for PSQ was determined by the receiver-operating characteristic curve (ROC). The mean age of patients was 49.3±9.6 years, and there were 80 women. The mean time for follow-up assessment was 31±5 months (range 24–35). Post-surgical success was 79.9% (n = 123) at 2 years follow up. The mean score for the total PSQ, PSQ-minor, and PSQ-moderate were 6.0 (SD = 1.6), 5.4 (SD = 1.9) and 6.5 (SD = 1.7), respectively. Total PSQ score was also significantly correlated with the total scores of the ODI. The optimal total PSQ cut-off point was determined as > 5.2 to predict surgical success in LDH patients, with 80.0% sensitivity and 75.6% specificity (AUC-0.814, 95% CI 0.703–0.926). This study showed that the PSQ could be considered a parameter for predicting surgical success in patients with LDH, and can be useful in clinical practice. PMID:27494617

  13. Sinus cut-off sign: A helpful sign in the CT diagnosis of diaphragmatic rupture associated with pleural effusion

    Kaya, Seyda Ors [Pamukkale University Medical School, Department of Thoracic Surgery, Denizli (Turkey)]. E-mail: skaya@pamukkale.edu.tr; Karabulut, Nevzat [Pamukkale University Medical School, Department of Radiology, Denizli (Turkey); Yuncu, Gokhan [Pamukkale University Medical School, Department of Thoracic Surgery, Denizli (Turkey); Sevinc, Serpil [Pamukkale University Medical School, Department of Thoracic Surgery, Denizli (Turkey); Kiroglu, Yilmaz [Pamukkale University Medical School, Department of Radiology, Denizli (Turkey)

    2006-08-15

    The objective of our study was to describe the 'sinus cut-off' sign at CT in the diagnosis of diaphragmatic rupture in patients with blunt abdominal trauma complicated with pleural effusion, and evaluate its utility in an experimental model. Between January 2004 and March 2005, we observed an unusual interruption of costophrenic sinus at CT in three patients with blunt abdominal trauma accompanied with pleural effusion. This observation prompted us to evaluate the utility of this sign in an experimental model. Laparotomically, we created 2 cm diapragmatic lacerations at each hemidiaphragm in two rabbits and pushed up the abdominal viscera with omentum through the defect. To simulate hemothorax, we also injected 5-10 mL of diluted contrast material into the pleural space. Using a dual-slice helical CT scanner, limited thoracoabdominal CT examination was performed before and after injection of intrapleural contrast material. The images were analyzed for the presence of CT signs for diaphragmatic injury. The left posterior costophrenic sulcus was interrupted in all of the three patients with left pleural effusion. While it was associated with other findings of diaphragmatic injury, the 'sinus cut-off sign' was the sole finding in one patient. The sinus cut-off sign was observed on the CT scans of 100% of the rabbits with a left and right sided diaphragmatic rupture. The 'sinus cut-off sign' is useful and can increase the CT detection of acute diaphragmatic injury associated with pleural effusion.

  14. Determining the waist circumference cut off which best predicts the metabolic syndrome components in urban Africans: the SABPA study

    Malan, Leone; Potgieter, Johannes Cornelis; Steyn, Hendrik Stefanus; J. Prinsloo; De Ridder, Johannes Hendrik

    2011-01-01

    Various studies have shown that the relationship between waist circumference (WC) and abdominal obesity is age, gender as well as ethnicity-dependent. WC criteria for Sub Saharan Africans have not been defined by the International Diabetes Federation (IDF). The aim was to determine which WC cut off best predicted Metabolic Syndrome (MetS) in a group of urban African teachers (80 males and 93 females). We determined sphygmomanometer blood pressure, WC, glucose, high density lipoprotein cholest...

  15. Influence of age and purpose for testing on the cut-off selection of serological methods in bovine neosporosis

    Álvarez-García, Gema; Collantes-Fernández, Esther; Costas, Eduardo; Rebordosa, Xabier; Ortega-Mora, Luis

    2003-01-01

    The aim of this study was to investigate the need for different cut-off points, according to animal age and the purpose of testing, for two of the most widely used serological techniques in bovine neosporosis, IFAT and a crude antigen ELISA (Civtest®, HIPRA). Therefore, the population reference sera used were defined using a combination of multiple criteria such as epidemiological/clinical and histopathological parameters and an immunoblot test. Firstly, foetuses and breeding cattle (heifers ...

  16. Extension of the cut-off in high-harmonic generation using two delayed pulses of the same colour

    We demonstrate a novel technique for an extension of the cut-off frequency in high-harmonic generation using a shaped field, consisting of two delayed pulses, identical in all parameters except a carrier envelope phase shift of π. We obtain high harmonics up to an energy of 5.5Up + Ip, surpassing the conventional limit of 3.17Up + Ip. For high intensities approaching the threshold for barrier suppression ionization, beyond which no harmonics are generated, this mechanism acquires practical importance as a means to overcome the limit imposed by saturation. We analyse the underlying mechanism using both classical and quantum approaches, and highlight the role of the shaped field in modifying the electron trajectories in the continuum to enhance the collection of kinetic energy from the driving field. Of greatest importance are the trajectories describing electrons ionized across the first peak of the laser field which receive the enhanced kinetic energies responsible for the cut-off extension above the conventional limit. Interestingly, the most energetic trajectories do not contribute to the harmonic cut-off in the single pulse case. We conclude with a discussion of the sub-cycle structure of the emitted harmonic radiation and possible applications of the technique.

  17. Adaptive determination of cut-off frequencies for filtering the in-cylinder pressure in diesel engines combustion analysis

    In-cylinder pressure analysis is a key tool for engine research and diagnosis and it has been object of study from the beginning of the internal combustion engines. One of its most useful application is combustion analysis on the basis of the First Law of Thermodynamics. However, heat release law calculations use the in-cylinder pressure derivative signal. Hence, the noise is increased and pressure filtering becomes necessary to remove high frequency noise, thus allowing for accurate combustion analyses. In this work, a methodology to set the cut-off frequency of a low-pass filter is proposed. Statistical criteria are used to separate the signal from the noise through the calculation of the Discrete Fourier Transform of several consecutive in-cylinder pressures cycles. Thus, only physically meaningful information is preserved. The proposed methodology is compared with some adaptive and non-adaptive algorithms used to select the cut-off frequencies, and it shows a good ability to adapt to different engine operating conditions. - Highlights: →Combustion analysis is performed by means of in-cylinder pressure measurement. →Filtering is necessary due to high noise and dispersion in the measurement. →A proposed methodology to select cut-off frequencies is proposed. →The methodology is compared with other filters, showing a better behaviour.

  18. Serum D-dimer concentrations in nephrotic syndrome track with albuminuria, not estimated glomerular filtration rate.

    Sexton, D J

    2012-01-01

    The nephrotic syndrome is associated with an increased risk of venous and arterial thrombosis. There are little published data on the distribution, interpretation or determinants of serum D-dimer levels in patients with the nephrotic syndrome. We aimed to describe this relationship.

  19. Interference from heterophilic antibodies in D-dimer assessment. A case report.

    Lippi, Giuseppe; Ippolito, Luigi; Tondelli, Maria Teresa; Favaloro, Emmanuel J

    2014-04-01

    We describe the case of a 3-year-old girl, admitted to the pediatric ward for three repeated episodes of severe migraine associated with vertigo, with onset 1 week after complete remission from an episode of chicken pox (i.e., varicella-zoster virus infection). All radiological and laboratory examinations were normal, except for a markedly elevated value of D-dimer (i.e. 8998 ng/ml; local reference range: < 243 ng/ml), measured with a commercial latex-enhanced immunoturbidimetric assay. After physical and Doppler ultrasound examination, possible presence of thrombosis was ruled out, and the patient was discharged. In the following year, however, her plasma D-dimer values always remained frankly elevated, so that an analytical interference was suspected. A plasma sample was treated with a specific heterophilic antibodies blocking reagent and then assayed along with the untreated sample, with these showing a marked discrepancy of D-dimer values, that is 232 versus 2877 ng/ml. These results, highly indicative for the presence of heterophilic antibodies, are discussed in the light of the serious challenges that this type of analytical interference may pose on quality and reliability of D-dimer testing. PMID:24253242

  20. Power-Law Entropy-Corrected Holographic Dark Energy in Ho\\v{r}ava-Lifshitz Cosmology with Granda-Oliveros Cut-off

    Pasqua, Antonio(Department of Physics, University of Trieste, Via Valerio, No. 2, 34127 Trieste, Italy); Chattopadhyay, Surajit; Myrzakulov, Ratbay

    2015-01-01

    In this paper, we study the Power Law Entropy Corrected Holographic Dark Energy (PLECHDE) model in the framework of a non-flat Universe and of Ho\\v{r}ava-Lifshitz cosmology with infrared cut-off given by recently proposed Granda-Oliveros cut-off, which contains one term proportional to the Hubble parameter squared $H^2$ and one term proportional to the first time derivative of the Hubble parameter $\\dot{H}$. Moreover, this cut-off is characterized by two constant parameters, $\\alpha$ and $\\be...

  1. D-dimer is useful in the diagnosis of cortical venous sinus thrombosis

    Misra Usha

    2009-01-01

    Full Text Available Background: Estimations of D-dimer correlate with deep vein thrombosis and pulmonary thromboembolism and may serve as a marker of cortical venous sinus thrombosis (CVST. Aim: To study the usefulness of D-dimer in the diagnosis of CVST. Materials and Methods: A total of 26 patients with CVST were subjected to a detailed medical history and neurological evaluation. A cranial MRI was carried out on a 1.5T scanner using T1, T2, and DWI sequences and two-dimensional time of flight MR venography. D-dimer was estimated using a rapid latex agglutination slide test using monoclonal antibodies. Results: The age of patients ranged between 16 and 70 years old (median 31 years old; 8 were males and were examined after a mean duration of 22 days of symptoms. Cortical venous thrombosis was attributed to puerperium in 4 patients, infection in 5 patients, and pregnancy, dehydration, insect bite, and migraine in 1 patient each. Superior sagittal sinus was involved in 15 patients, transverse sinus in 16 patients, straight sinus in 3 patients, sigmoid sinus in 7 patients, and cavernous and deep system in 1 patient each. A total of 12 patients had more than one sinus involvement. D-dimer was positive in 20 patients and correlated with the duration of symptoms but not with the extent of sinus thrombosis and the outcome. Conclusion: D-dimer is useful in patients suspected of CVST and patients with positive test results should be urgently sent for MR imaging.

  2. The Diagnostic Value of D-dimer, Procalcitonin and CRP in Acute Appendicitis

    Bulent Kaya, Baris Sana, Cengiz Eris, Koray Karabulut, Orhan Bat, Riza Kutanis

    2012-01-01

    Full Text Available BACKGROUND: The early diagnosis of acute abdomen is of great importance. To date, several inflammatory markers have been used for the diagnosis of acute abdominal conditions, including acute appendicitis. The aim of this study was to evaluate the diagnostic utility of D-dimer, Procalcitonin (PCT and C-reactive protein (CRP measurements in the acute appendicitis.METHODS: This prospective study was conducted between March 1st, 2010 and July 1st, 2011. In this period, seventy-eight patients were operated with the diagnosis of acute appendicitis, and D-dimer, PCT and CRP levels of the patients were measured. The patients were grouped as phlegmonous appendicitis (Group 1, gangrenous appendicitis (Group 2, perforated appendicitis (Group 3 and negative appendectomy (Group 4 according to the surgical findings and histopathological results.RESULTS: Of 78 patients, 54 (69.2 % were male and 24 (30.8 % were female, and the mean age was 25.4 ± 11.1 years (range, 18 to 69 years. 66 (84.6 % patients had increased leukocyte count (white blood cell count. The PCT values were higher than the upper normal limit in 20 (25.6% patients, followed by D-dimer in 22 (28.2 % patients and CRP in 54 (69.2 % patients. The diagnostic value of leukocyte count and CRP in acute appendicitis was higher than that of the other markers, whereas leukocyte count showed very low specificity. CRP values were higher in perforated appendicitis when compared with the phlegmonous appendicitis (p<0.05. However, PCT and D-dimer showed lower diagnostic values (26% and 31%, respectively.CONCLUSION: An increase in CRP levels alone is not sufficient to make the diagnosis of acute appendicitis. However, CRP levels may differentiate between phlegmonous appendicitis and perforated appendicitis. Due to their low sensitivity and diagnostic value, PCT and D-dimer are not better markers than CRP for the diagnosis of acute appendicitis.

  3. Power-law and Logarithmic Entropy Corrected Holographic Dark Energy Models in Brans-Dicke Cosmology with Granda-Oliveros Cut-Off

    Pasqua, Antonio(Department of Physics, University of Trieste, Via Valerio, No. 2, 34127 Trieste, Italy); Chattopadhyay, Surajit; Myrzakulov, Ratbay

    2015-01-01

    In this paper, the cosmological implications of the Power Law Entropy Corrected Holographic Dark Energy (PLECHDE) and the Logarithmic Entropy Corrected Holographic Dark Energy (LECHDE) models in the context of Brans-Dicke (BD) cosmology for both non-interacting and interacting DE and Dark Matter (DM) are studied. As the system infrared cut-off, we choose the recently proposed Granda-Oliveros cut-off, which contains a term proportional to the first time derivative of the Hubble parameter and o...

  4. Optimal Cut-Off Points on the Health Anxiety Inventory, Illness Attitude Scales and Whiteley Index to Identify Severe Health Anxiety

    Erik Hedman; Mats Lekander; Brjánn Ljótsson; Nils Lindefors; Christian Rück; Gerhard Andersson; Erik Andersson

    2015-01-01

    Background Health anxiety can be viewed as a dimensional phenomenon where severe health anxiety in form of DSM-IV hypochondriasis represents a cut-off where the health anxiety becomes clinically significant. Three of the most reliable and used self-report measures of health anxiety are the Health Anxiety Inventory (HAI), the Illness Attitude Scales (IAS) and the Whiteley Index (WI). Identifying the optimal cut-offs for classification of presence of a diagnosis of severe health anxiety on thes...

  5. Interpretation of increments in serial tumour biomarker concentrations depends on the distance of the baseline concentration from the cut-off

    Petersen, Per Hyltoft; Söletormos, Georg; Frejstrup Pedersen, Merete;

    2011-01-01

    In the management of breast cancer, several algorithms for interpretation of measured concentrations during monitoring have been introduced, without objective evaluation of their performance regarding the distance of the starting concentration from the cut-off concentration.......In the management of breast cancer, several algorithms for interpretation of measured concentrations during monitoring have been introduced, without objective evaluation of their performance regarding the distance of the starting concentration from the cut-off concentration....

  6. The assessment of anorexia in patients with cancer: cut-off values for the FAACT–A/CS and the VAS for appetite

    Blauwhoff-Buskermolen, S.; Ruijgrok, C.; Ostelo, R. W.; de Vet, H. C. W.; Verheul, H.M.W.; de van der Schueren, M. A. E.; Langius, J. A. E.

    2015-01-01

    Purpose Anorexia is a frequently observed symptom in patients with cancer and is associated with limited food intake and decreased quality of life. Diagnostic instruments such as the Anorexia/Cachexia Subscale (A/CS) of the Functional Assessment of Anorexia/Cachexia Therapy (FAACT) questionnaire and the visual analog scale (VAS) for appetite have been recommended in the assessment of anorexia, but validated cut-off values are lacking. This study aimed to obtain cut-off values of these instrum...

  7. The entropy functional measure on trajectories of a Markov diffusion process and its estimation by the process' cut off applying the impulse control

    Lerner, Vladimir S

    2012-01-01

    The paper extends conventional Shannon entropy' measure of a random state on an integral information measure of the Markov diffusion process on its trajectories- solutions of Ito's controllable stochastic equation. The introduced method of cutting off the process by applying an impulse control estimates the cut off information, accumulated by the process' inner connections between its states. It has shown that such a functional information measure contains more information than the sum of Shannon's entropies counted for all process' separated states.

  8. Determination of the optimal cut-off point for ELISA test for diagnosis of brucellosis in Iran

    Soudbakhsh A

    2009-09-01

    Full Text Available "n Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} Background: Finding a reliable diagnostic method for brucellosis is the most challengeable problem. In this study we determined the optimal diagnostic cut-off point for ELISA test."n"nMethods: We gathered 56 confirmed cases of brucellosis. Furthermore blood samples from 126 controls including 73 healthy controls and 53 without brucellosis febrile patients were collected. In all of the cases and controls ELISA Ig G and ELISA Ig M levels were measured and compared with each other by Box plot graph and the Receiver Operating Characteristic (ROC curve. The sensitivity and specificity of ELISA Ig G and Ig M were fixed in different cut-off values and Ig G and Ig M levels yielding maximal sensitivity plus specificity were selected for determination of optimal cut-off point."n"nResults: The nineteen patients had positive blood cultures for Brucella melitensis. The standard agglutination test results were 1/160 or more in 54 patients. The Box plot graph indicated a high degree of dispersion for Ig G and Ig M data in patients with brucellosis compared with febrile patients without brucellosis and healthy controls. We observed partial overlap for Ig M data (not for Ig G between cases and controls. The area under ROC curve for

  9. An optimal cut-off point for the calving interval may be used as an indicator of bovine abortions.

    Bronner, Anne; Morignat, Eric; Gay, Emilie; Calavas, Didier

    2015-10-01

    The bovine abortion surveillance system in France aims to detect as early as possible any resurgence of bovine brucellosis, a disease of which the country has been declared free since 2005. It relies on the mandatory notification and testing of each aborting cow, but under-reporting is high. This research uses a new and simple approach which considers the calving interval (CI) as a "diagnostic test" to determine optimal cut-off point c and estimate diagnostic performance of the CI to identify aborting cows, and herds with multiple abortions (i.e. three or more aborting cows per calving season). The period between two artificial inseminations (AI) was considered as a "gold standard". During the 2006-2010 calving seasons, the mean optimal CI cut-off point for identifying aborting cows was 691 days for dairy cows and 703 days for beef cows. Depending on the calving season, production type and scale at which c was computed (individual or herd), the average sensitivity of the CI varied from 42.6% to 64.4%; its average specificity from 96.7% to 99.7%; its average positive predictive value from 27.6% to 65.4%; and its average negative predictive value from 98.7% to 99.8%. When applied to the French bovine population as a whole, this indicator identified 2-3% of cows suspected to have aborted, and 10-15% of herds suspected of multiple abortions. The optimal cut-off point and CI performance were consistent over calving seasons. By applying an optimal CI cut-off point to the cattle demographics database, it becomes possible to identify herds with multiple abortions, carry out retrospective investigations to find the cause of these abortions and monitor a posteriori compliance of farmers with their obligation to report abortions for brucellosis surveillance needs. Therefore, the CI could be used as an indicator of abortions to help improve the current mandatory notification surveillance system. PMID:26318526

  10. The use of vertical cut-off rigidities in computations of cosmic ray spectra on the Earth's orbits

    Simplified assumptions for computing spectral probabilities of cosmic rays transmission into the geomagnetic field are used to estimate their flux and energy spectra on low altitude orbits. For this purpose, three types of planetary tables of vertical cut-off rigidities and two approaches are used for their extrapolations from the Earth's surface to the altitude of satellite. A comparison of the results leads to errors insignificant in estimation of the radiation exposure by cosmic rays influenced by the geomagnetic field at low altitudes. (author)

  11. The Cut-Off Values of Anthropometric Indices for Identifying Subjects at Risk for Metabolic Syndrome in Iranian Elderly Men

    Mojgan Gharipour; Masoumeh Sadeghi; Minoo Dianatkhah; Shirin Bidmeshgi; Alireza Ahmadi; Marzieh Tahri; Nizal Sarrafzadegan

    2014-01-01

    Aim. This study aimed to investigate which anthropometric indices could be a better predictor of metabolic syndrome (MetS) and the cut-off points for these surrogates to appropriately differentiate MetS in the Iranian elderly. Method. The present cross-sectional study was conducted on a sample of Isfahan Healthy Heart Program (IHHP). MetS was defined according to Third Adult Treatment Panel (ATPIII). In total, 206 elderly subjects with MetS criteria were selected. Anthropometric indices were ...

  12. A neoantigenic determinant in the D-dimer fragment of fibrin

    Lugovskoy, E.V.; Kolesnikova, I.N.; Gritsenko, P.G.; Zolotareva, E.N.; Gaffney, P.; Nieuwenhuizen, W.; Komisarenko, S.V

    2002-01-01

    Monoclonal antibody (mAb) III-3b binds D-dimer with Kd = 1.4 × 10-10 M without cross-reaction with fibrin(ogen). The epitope for this mAb is in Bβ134-190, presumably in Bβ155-160. The latter site is buried in the coiled coil structure of fibrin(ogen) but it is exposed as a neoantigenic determinant i

  13. Determination of the accuracy and optimal cut-off point for ELISA test in diagnosis of human brucellosis in Iran.

    Mehrdad Hasibi

    2013-10-01

    Full Text Available In endemic area the most challenging problem for brucellosis is to find a reliable diagnostic method. In this case-control study, we investigated the accuracy of ELISA test for diagnosis of human brucellosis and determined the optimal cut-off value for ELISA results in Iran. The laboratory diagnosis of brucellosis was performed by blood isolation of Brucella organism with a BACTEC 9240 system and/or detection of Brucella antibodies by standard agglutination test (titer ≥ 1:160. Serum level of ELISA IgG and ELISA IgM from 56 confirmed cases of brucellosis and 126 controls were compared with each other by Box plot graph and Receiver Operating Characteristic (ROC curve. Box plot graphs showed the high degree of dispersion for IgG and IgM data in patients compared with all controls. We observed partially overlapping for IgM data (not for IgG between cases and controls in graphs. The area under ROC curve for distinguishing between cases and controls was larger for IgG compared to IgM. Based on results of this study, ELISA IgG test was more reliable than ELISA IgM test in diagnosis of human brucellosis in Iran. Using a cut-off of 10 IU/ml and 50 IU/ml had most sensitivity (92.9% and most specificity (100% for ELISA IgG test, respectively.

  14. Analysis of the acoustic cut-off frequency and HIPs in six Kepler stars with stochastically excited pulsations

    Jimenez, A; Hernandez, F Perez; Mathur, S

    2015-01-01

    Gravito-acoustic modes in the Sun and other stars propagate in resonant cavities with a frequency below a given limit known as the cut-off frequency. At higher frequencies, waves are no longer trapped in the stellar interior and become traveller waves. In this article we study six pulsating solar-like stars at different evolutionary stages observed by the NASA Kepler mission. These high signal-to-noise targets show a peak structure that extends at very high frequencies and are good candidates for studying the transition region between the modes and the interference peaks or pseudo-modes. Following the same methodology successfully applied on Sun-as-a-star measurements, we uncover the existence of pseudo-modes in these stars with one or two dominant interference patterns depending on the evolutionary stage of the star. We also infer their cut-off frequency as the midpoint between the last eigenmode and the first peak of the interference patterns. By using ray theory we show that, while the period of one of the...

  15. Cut-off scaling of high-harmonic generation driven by a femtosecond visible optical parametric amplifier

    We studied high-harmonic generation (HHG) in Ar, Ne and He gas jets using a broadly tunable, high-energy optical parametric amplifier (OPA) in the visible wavelength range. We optimized the noncollinear OPA to deliver tunable, femtosecond pulses with 200-500 µJ energy at the 1 kHz repetition rate with excellent spatiotemporal properties, suitable for HHG experiments. By tuning the central wavelength of the OPA while keeping other parameters (energy, duration and beam size) constant, we experimentally studied the scaling law of cut-off energy with the driver wavelength in helium. Our measurements show a λ1.7+0.2 dependence of the HHG cut-off photon energy over the full visible range in agreement with previous experiments of near- and mid-IR wavelengths. By tuning the central wavelength of the driver source, the high-order harmonic spectra in the extreme ultraviolet cover the full range of photon energy between ∼25 and ∼100 eV. Due to the high coherence intrinsic in HHG, as well as the broad and continuous tunability in the extreme UV range, a high energy, high repetition rate version of this source might be an ideal seed for free electron lasers.

  16. Dynamic Changes, Cut-Off Points, Sensitivity, and Specificity of Laboratory Data to Differentiate Macrophage Activation Syndrome from Active Disease

    Raheleh Assari

    2015-01-01

    Full Text Available Purpose. To compare the laboratory data and changes in these data between patients with MAS and patients with flare-up of the autoimmune diseases. Methods. In a prospective study, the static laboratory data and dynamic changes in the selected data in 17 consecutive patients with MAS and 53 patients with active disease of SJIA, PJIA, Kawasaki disease, and SLE were compared. The ROC curve analysis was used to evaluate cut-off points, sensitivity, and specificity of the static and dynamic laboratory data to differentiate between MAS and active disease. Results. In the MAS group, the mean CRP3, ALT, AST, total bilirubin, ferritin, LDH, PT, PTT, and INR were significantly higher and the mean WBC2, PMN2, Lymph2, Hgb1, 2, 3, ESR2, serum albumin, and sodium were significantly lower than in control group. Some of the important cut-off points were PLT2 38.5, ALT > 38, WBC 5277 ng/mL. Conclusion. The dynamic changes in some laboratory data, especially PLT, can differentiate between MAS and active disease. The changes in WBC, PMN, and ESR and the levels of the liver enzymes may also be helpful in the early differentiation. Very high levels of ferritin may also help the diagnosis along with other clinical and laboratory signs.

  17. STS-114: Engine Cut-Off Sensors Are a No-Go: Teaching Notes for NASA Case Study

    Ransom, Khadijah S.; Johnson, Grace K.

    2013-01-01

    This case study format is intended to simulate the experience of facing the same difficult challenges and making the same critical decisions as managers, engineers, and scientists in the Space Shuttle Program. It has been designed for use in the classroom setting to help students develop skills related to decision-making. Students will read about the engine cut-off sensor anomaly which created challenges during the STS-114 mission and have the opportunity to make decisions as lead NASA engineers and Mission Management Team members. Included within this document are three case study presentation options - class discussion, group activity, and open-ended research. Please read the full case prior to in-class presentation to allow ample time for students' analysis and reflection, as well as to prepare additional questions. activities or exercises, material selection, etc. Depending upon the setting of your presentation and the number of participants, please choose at least one presentation format beforehand and plan accordingly. You may expect the following learning objectives by using the proposed formats. Learning Objectives: To enable students to experience the responsibilities of NASA management, engineers, and analysis; to discover possible procedures for investigating system anomalies; to become familiar with the liquid hydrogen low level engine cut-off sensor, including its function, connecting components, and location within the Space Shuttle; and to encourage critical analysis and stimulating discussion of Space Shuttle mission challenges.

  18. Accuracy of cut-off value by measurement of third molar index: Study of a Colombian sample.

    De Luca, Stefano; Aguilar, Lina; Rivera, Marcela; Palacio, Luz Andrea Velandia; Riccomi, Giulia; Bestetti, Fiorella; Cameriere, Roberto

    2016-04-01

    The aim of this cross-sectional study was to test the accuracy of cut-off value of 0.08 by measurement of third molar index (I3M) in assessing legal adult age of 18 years in a sample of Colombian children and young adults. Digital orthopantomographs of 288 Colombian children and young adults (163 girls and 125 boys), aged between 13 and 22 years, were analysed. Concordance correlation coefficient (ρc) and κ statistics (Cohen's Kappa coefficient) showed that repeatability and reproducibility are high for both intra- and inter-observer error. κ statistics for intra- and inter-observer agreement in decision on adult or minor was 0.913 and 0.877, respectively. Age distribution gradually decreases as I3M increases in both girls and boys. For girls, the sensitivity test was 95.1% (95% CI 87.1%-95%) and specificity was 93.8% (95% CI 87.1%-98.8%). The proportion of correctly classified individuals was 95.1%. For boys, the sensitivity test was 91.7% (95% CI 85.1%-96.8%) and specificity was 90.6% (95% CI 82.1%-97.8%). The proportion of correctly classified individuals was 89.7%. The cut-off value of 0.08 is highly useful to determine if a subject is 18 years of age or older or not. PMID:26898677

  19. CFT dual of the AdS Dirichlet problem : Fluid/Gravity on cut-off surfaces

    Brattan, Daniel K; Loganayagam, R; Rangamani, Mukund

    2011-01-01

    We study the gravitational Dirichlet problem in AdS spacetimes with a view to understanding the boundary CFT interpretation. We define the problem as bulk Einstein's equations with Dirichlet boundary conditions on fixed timelike cut-off hypersurface. Using the fluid/gravity correspondence, we argue that one can determine non-linear solutions to this problem in the long wavelength regime. On the boundary we find a conformal fluid with Dirichlet constitutive relations, viz., the fluid propagates on a `dynamical' background metric which depends on the local fluid velocities and temperature. This boundary fluid can be re-expressed as an emergent hypersurface fluid which is non-conformal but has the same value of the shear viscosity as the boundary fluid. The hypersurface dynamics arises as a collective effect, wherein effects of the background are transmuted into the fluid degrees of freedom. Furthermore, we demonstrate that this collective fluid is forced to be non-relativistic below a critical cut-off radius in...

  20. d-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study

    Bernardi, Enrico; Prandoni, Paolo; Lensing, Anthonie W A; Agnelli, Giancarlo; Guazzaloca, Giuliana; Scannapieco, Gianluigi; Piovella, Franco; Verlato, Fabio; Tomasi, Cristina; Moia, Marco; Scarano, Luigi; Girolami, Antonio

    1998-01-01

    Objective To investigate the efficacy of using a rapid plasma d-dimer test as an adjunct to compression ultrasound for diagnosing clinically suspected deep vein thrombosis. Design d-dimer concentrations were determined in all patients with a normal ultrasonogram at presentation. Repeat ultrasonography was performed 1 week later only in patients with abnormal d-dimer test results. Main outcome measure Patients with normal ultrasonograms were not treated with anticoagulants and were followed for 3 months for thromboembolic complications. Setting University research and affiliated centres. Subjects 946 patients with clinically suspected deep vein thrombosis. Results Ultrasonograms were abnormal at presentation in 260 (27.5%) patients. Of the remaining 686 patients tested for d-dimer, 88 (12.8%) had abnormal concentrations. During follow up venous thromboembolic complications occurred in one of the 598 patients who were not treated with anticoagulants and who had an initial normal ultrasonogram and d-dimer concentration, whereas thromboembolic complications occurred in two of the 83 untreated patients who had abnormal d-dimer concentrations but a normal repeat ultrasonogram. The cumulative incidence of venous thromboembolic complications during follow up was 0.4% (95% confidence interval 0% to 0.9%). The rapid plasma d-dimer test used as an adjunct to compression ultrasonography resulted in a reduction in the mean number of repeat ultrasound examinations and additional hospital visits from 0.7 to 0.1 per patient. Conclusions Testing for d-dimer as an adjunct to a normal baseline ultrasound examination decreased the number of subsequent ultrasound examinations considerably without any increased risk of venous thromboembolic complications in patients not receiving anticoagulants. The use of ultrasound and testing for d-dimer enabled treatment decisions to be made at the time of presentation in most patients. Key messagesPatients with clinically suspected deep vein

  1. D-Dimer Levels Predict Myocardial Injury in ST-Segment Elevation Myocardial Infarction: A Cardiac Magnetic Resonance Imaging Study

    Song, Young Bin; Lima, Joao A. C.; Guallar, Eliseo; Choe, Yeon Hyeon; Hwang, Jin Kyung; Kim, Eun Kyoung; Yang, Jeong Hoon; Hahn, Joo-Yong; Choi, Seung-Hyuk; Lee, Sang-Chol; Lee, Sang Hoon; Gwon, Hyeon-Cheol

    2016-01-01

    Objectives Elevated D-dimer levels on admission predict prognosis in patients undergoing primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI), but the association of D-dimer levels with structural markers of myocardial injury in these patients is unknown. Methods We performed cardiac magnetic resonance (CMR) imaging in 208 patients treated with primary PCI for STEMI. CMR was performed a median of 3 days after the index procedure. Of the 208 patients studied, 75 patients had D-dimer levels above the normal range on admission (>0.5 μg/mL; high D-dimer group) while 133 had normal levels (≤0.5 μg/mL; low D-dimer group). The primary outcome was myocardial infarct size assessed by CMR. Secondary outcomes included area at risk (AAR), microvascular obstruction (MVO) area, and myocardial salvage index (MSI). Results In CMR analysis, myocardial infarct size was larger in the high D-dimer group than in the low D-dimer group (22.3% [16.2–30.5] versus 18.8% [10.7–26.7]; p = 0.02). Compared to the low D-dimer group, the high D-dimer group also had a larger AAR (38.1% [31.7–46.9] versus 35.8% [24.2–45.3]; p = 0.04) and a smaller MSI (37.7 [28.2–46.9] versus 47.1 [33.2–57.0]; p = 0.01). In multivariate analysis, high D-dimer levels were significantly associated with larger myocardial infarct (OR 2.59; 95% CI 1.37–4.87; p<0.01) and lower MSI (OR 2.62; 95% CI 1.44–4.78; p<0.01). Conclusions In STEMI patients undergoing primary PCI, high D-dimer levels on admission were associated with a larger myocardial infarct size, a greater extent of AAR, and lower MSI, as assessed by CMR data. Elevated initial D-dimer level may be a marker of advanced myocardial injury in patients treated with primary PCI for STEMI. PMID:27513758

  2. Impact of High-Cut-Off Dialysis on Renal Recovery in Dialysis-Dependent Multiple Myeloma Patients: Results from a Case-Control Study.

    Hans U Gerth

    Full Text Available High-cut-off hemodialysis (HCO-HD can effectively reduce high concentrations of circulating serum free light chains (sFLC in patients with dialysis-dependent acute kidney injury (AKI due to multiple myeloma (MM. Therefore, the aim of this study was to analyze renal recovery in a retrospective single-center cohort of dialysis-dependent MM patients treated with either conventional HD (conv. HD or HCO-HD.The final cohort consisted of 59 patients treated with HCO-HD (n = 42 or conv. HD (n = 17. A sustained sFLC response was detected in a significantly higher proportion of HCO-HD patients (83.3% compared with conv. HD patients (29.4%; p = 0.007. The median duration of sFLC required to reach values <1000 mg/l was 14.5 days in the HCO-HD group and 36 days in the conv. HD group. The corresponding rates of renal recovery were 64.3% and 29.4%, respectively (chi-squared test, p = 0.014. Multivariate regression and decision tree analysis (recursive partitioning revealed HCO-HD (adjusted odds ratio [OR] 6.1 [95% confidence interval (CI 1.5-24.5], p = 0.011 and low initial uric acid values (adjusted OR 1.3 [95%CI 1.0-1.7], p = 0.045 as independent and paramount variables associated with a favorable renal outcome.In summary, the results from this retrospective case-control study suggest in addition to novel agent-based chemotherapy a benefit of HCO-HD in sFLC removal and renal outcome in dialysis-dependent AKI secondary to MM. This finding was especially pertinent in patients with low initial uric acid values, resulting in a promising renal recovery rate of 71.9%. Further prospective studies are warranted.

  3. Prognostic associations of preoperative plasma levels of fibrinogen and D-dimer after curative resection in patients with colorectal cancer

    王俊锋

    2013-01-01

    Objective To explore the associations of preoperative plasma levels of fibrinogen and D-dimer with clinico-pathologic parameters and overall survival in colorectal cancer patients after curative resection.Methods From

  4. Design and construction of a seepage cut off wall using the slurry trench technique in cold temperatures at the Horizon Dam project

    Barr, L.A.; Sobkowicz, J.C. [Thurber Engineering Ltd., Calgary, AB (Canada)

    2010-07-01

    This paper described the design and construction of a soil-cement-bentonite seepage cut off water that was constructed in 2007 as part of the Horizon Dam project at Canadian Natural Resources Ltd. Horizon oil sands site. The Horizon Dam is an earth retention structure which diverts the Tar River around the mine and plant site, and creates a man-made lake providing replacement fish habitat. It was necessary to build the cut off wall to control seepage through the native coarse grained alluvial deposits encountered under the dam and to minimize the risk of piping due to large hydraulic gradients created by the lake. This paper discussed the design of the dam and the field investigation using different geotechnical drilling methods, geophysics and in-situ testing to support design of the cut off wall. Specifically, the paper discussed a literature review and laboratory testing program that were carried out to assess the appropriate backfill mix to be used. The construction of the cut off wall took place at the end of winter using the slurry trench technique. As such, some unique constructability issues were encountered because of cold weather, the use of cement in the backfill, and the native soil conditions. It was concluded that although strict quality control/assurance measures were implemented, one defect in the cut off wall occurred, which required mitigation to provide a product that met the design intentions. 5 refs., 1 tab., 15 figs.

  5. Pulmonary perfusion imaging combined with Wells score and D-dimer assay for the diagnosis of acute pulmonary embolism

    Objective: To investigate the value of the Wells score and D-dimer assay in assisting pulmonary perfusion imaging (PPI) for the diagnosis of acute pulmonary embolism (APE). Methods: One hundred twenty-one patients with suspected APE were studied from January, 2006 to December, 2008. All patients underwent the Wells score, the quantitative D-dimer assay, chest X-ray photography, and PPI. The diagnostic sensitivity, specificity, positive predictive value and negative predictive value of PPI with the assistance of Wells score and D-dimer assay were calculated. Results: Fifty (41.3%) patients were diagnosed with APE. PPI combined with chest X-ray photography (Q/X scan) showed positive results in 49 patients. The sensitivity, specificity, positive predictive value and negative predictive value of the Q/X scan were 86.0% (43/50), 91.5% (65/71), 87.8% (43/49) and 90.3% (65/72), respectively. With assistance of Wells score >4 and D-dimer ≥0.5 mg/L, Q/X scan had a positive predictive value of 100.0% (29/29), for patients with Wells score ≤4 and D-dimer <0.5 mg/L, the negative predictive value for Q/X scan was 100.0% (41/41). Conclusion: Combined with Wells score and D-dimer assay, PPI can make accurate diagnosis of APE. (authors)

  6. Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion

    Hasan Onur Topçu

    2015-01-01

    Full Text Available We aimed to evaluate the diagnostic accuracy of serum D-dimer levels in pregnant women with adnexal torsion (AT. The pregnant women with ovarian cysts who suffered from pelvic pain were divided into two groups; the first group consisted of the cases with surgically proven as AT (n = 17 and the second group consisted of the cases whose pain were resolved in the course of follow-up period without required surgery (n = 34. The clinical characteristics and serum D-dimer levels were compared between the groups. Patients with AT had a higher rate of elevated serum white blood cell (WBC count (57% vs. 16%, p = 0.04 and serum D-dimer levels (77% vs. 21%, p < 0.01 on admission in the study group than in the control group. Elevated D-dimer and cyst diameter larger than 5 cm yielded highest sensitivity (82% for each; whereas the presence of nausea and vomiting and elevated CRP had the highest specificity (85% and 88%, respectively. This is the first study that evaluates the serum D-dimer levels in humans in the diagnosis of AT, and our findings supported the use of D-dimer for the early diagnosis of AT in pregnant women.

  7. On a holographic dark energy model with a Nojiri-Odintsov cut-off in general relativity

    Khurshudyan, M

    2016-01-01

    In this paper we consider the models of the accelerated expanding large scale universe~(according to general relativity) containing a generalized holographic dark energy with a Nojiri - Odintsov cut - off. The second component of the darkness is assumed to be the pressureless cold dark matter according to observed symmetries of the large scale universe. Moreover, we assume specific forms of the interaction between these two components and besides the cosmographic analysis, we discuss appropriate results from $Om$ and $Om3$ analysis and organize a closer look to the models via the statefinder hierarchy analysis, too. In this way we study mainly impact of the interaction on the dynamics of the background of our universe~(within specific forms of interaction). To complete the cosmographic analysis, the present day values of the statefinder parameters $(r,s)$ and $(\\omega^{\\prime}_{de}, \\omega_{de})$ has been estimated for all cases and the validity of the generalized second law of thermodynamics is demonstrated....

  8. Prevalence and cut-off point of vitamin D deficiency among secondary students of Arak, Iran in 2010

    Afsaneh Talaei

    2012-01-01

    Full Text Available Introduction: Vitamin D has a basic role in bone growth and metabolism and has been noticed for its important role in many diseases, such as diabetes, depression, hypertension, and cardiovascular disease. Regarding some studies, detection of vitamin D deficiency in different places has important implication for health. This study determined prevalence of vitamin D deficiency in Arak, a centrally located city in Iran. Materials and Methods: Based upon a cross-sectional study in 2010, 420 students 10--16 years old including 220 girls and 200 boys, studied at Arak secondary schools, were selected by a multistage sampling. The level of 25 (OH D and PTH (parathormone was measured and also the prevalence of vitamin D deficiency in different intensities was evaluated and compared between girls and boys by the Student t-test. Vitamin D deficiency for the students was categorized into three intensities based on three levels of 25 (OH D: mild deficiency - 15 ≤ 25 (OH D < 20 ng/ml, moderate deficiency -- 8 ≤ 25 (OH < 15 ng/ml, severe deficiency - 25 (OH <8 ng/ml. The relationship between the 25 (OH D and PTH was assessed by Scatter chart to define cut-off points for vitamin D deficiency. Results: Based on 25 (OH D < 20 ng/ml, 84% of the students had vitamin D deficiency including 60.7% mild, 22.4% moderate, and 0.7% severe. Three local cut-off points including 13, 21, and 33 ng/ml were defined in the Scatter chart. The results showed that the deficiency of vitamin D in girls is much more than that in boys (P = 0.05. Conclusion: The high prevalence of vitamin D deficiency could be probably a result of different etiologies. We recommended that people should be encouraged to take vitamin D and calcium supplements and also they should have more exposure to the sunlight.

  9. Predictive value of elevated D-dimer in patients undergoing primary angioplasty for ST elevation myocardial infarction.

    Akgul, Ozgur; Uyarel, Huseyin; Pusuroglu, Hamdi; Gul, Mehmet; Isiksacan, Nilgun; Turen, Selahattin; Erturk, Mehmet; Surgit, Ozgur; Cetin, Mustafa; Bulut, Umit; Baycan, Omer F; Uslu, Nevzat

    2013-10-01

    The aim of this study was to evaluate the prognostic value of D-dimer in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). The prognostic value of D-dimer has been documented in patients with acute coronary syndrome without ST-segment elevation. However, its value in acute ST-segment elevation myocardial infarction (STEMI) remains unclear. We prospectively enrolled 453 consecutive STEMI patients (mean age 55.6 ± 12.4 years, 364 male, 89 female) undergoing primary PCI. The study population was divided into tertiles based on admission D-dimer values. The high D-dimer group (n = 151) was defined as a value in the third tertile [>0.72 ug/ml fibrinogen equivalent units (FEU)], and the low D-dimer group (n = 302) included those patients with a value in the lower two tertiles (≤0.72 ug/ml FEU). Clinical characteristics, in-hospital and 6-month outcomes of primary PCI were analyzed. The patients of the high D-dimer group were older (mean age 60.1 ± 13.5 versus 52.4 ± 10.6, P 0.72 ug/ml FEU) was found to be a powerful independent predictor of 6-month all-cause mortality (odds ratio: 10.1, 95% confidence interval: 1.24-42.73, P = 0.03). These results suggest that a high admission D-dimer, level was associated with increased in-hospital cardiovascular mortality and 6-month all-cause mortality in patients with STEMI undergoing primary PCI. PMID:23571687

  10. Complementarity of lung scintigraphy and D-dimer test in pulmonary embolism

    D-dimer assay (DDA), measuring fibrin degradation products, was compared with lung scintigraphy (LS) in a prospective unselected series of 83 consecutive patients referred owing to suspicion of pulmonary embolism (PE). This patient series was also used to compare several methods of performing and interpreting LS images. The final diagnosis was established independently by a separate panel with all available information except for the result of DDA. D-dimer was determined by ELISA (threshold value 500 ng/ml). LS, including perfusion (.Q) and pseudo-ventilation (Technegas) (.V), was classified according to PIOPED, (1) immediately by the physician on duty, and (2) retrospectively by a blinded panel. A positive (19) or negative (61) diagnosis of PE was achieved in 80 patients, the prevalence of PE being 24%. Only one false-negative was noted on DDA (sensitivity=95%) but there were 42 false-positives (specificity=31%), resulting in a positive predictive value of 30% and a negative predictive value of 95%. Emergency and retrospective interpretations of LS were close (kappa=0.4). In a minority of patients, PE may be excluded with reasonable certainty if DDA is normal, resulting in a significant saving in terms of time and money. (orig.). With 3 tabs

  11. Role of D-Dimer, Fibrinogen and DDimer/Fibrinogen Rate in the Diagnosis of Pulmonary Embolism

    Sureyya Yilmaz1

    2016-04-01

    Full Text Available Objective: The migration of a blood clot from the systemic circulation to pulmonary veins is called pulmonary embolism (PE. Pulmonary embolism is difficult to diagnose. The aim of the present study is to investigate the utility and diagnostic contribution of d-dimer, fibrinogen level, and Ddimer/Fibrinogen (D/F rate which are quick, non-invasive, affordable and easily obtainable laboratory tests in PE. Methods: We have evaluated the diagnostic value of D/F rate in 118 patients who were suspected to have PE. Diagnosis of PE was made by computerized tomographic pulmonary angiography. D-dimer level was above normal in all patients. Initially, Wells clinical scoring was applied on the patients and their d-dimer and fibrinogen levels were measured. Results: Seventy seven patients were detected as PE positive (+ and 41 were detected as PE negative (-. Forty-eight of the cases (40.7% were male; the average age was 49.77±19.46 (15-86 years. Between PE (+ and PE (- patients, d-dimer, fibrinogen, and D/F rate median values and standard derivations were detected to be different and statistically significant. Conclusion: According to this study approach to the patients with suspected from PE, D/F ratio is valuable than d-dimer, and fibrinogen level is significantly lower in patients with PE (+ than patients with PE (-.

  12. Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China

    HOU Xin Guo; ZHANG Xiu Ping; JIANG Mei; WANG Wei Qing; NING Guang; ZHENG Hui Zhen; MA Ai Xia; SUN Yu; SONG Jun; LIN Peng; LIANG Kai; WANG Chuan; LIU Fu Qiang; LI Wen Juan; XIAO Juan; GONG Lei; WANG Mei Jian; LIU Ji Dong; YAN Fei; YANG Jun Peng; WANG Ling Shu; TIAN Meng; MA Ze Qiang; ZHAO Ru Xing; JIANG Ling; CHEN Li; YANG Wei Fang; WANG Ji Xiang; LI Cheng Qiao; WANG Yu Lian; LIU Shu Min; Hu Xiu Ping

    2014-01-01

    Objective To study the optimal waist circumference (WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome (MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China.

  13. 吉林省新生儿先天性甲状腺功能减低症筛查切值研究%A research on cut off value of thyroid stimulating hormone for newborn congenital hypothyroidism screening in Jilin province

    万立新; 张雯艳; 刘颖; 郝鹏楷; 赵迅; 张桂荣

    2013-01-01

    目的 建立吉林省新生儿先天性甲状腺功能减低症(CH)筛查TSH实验切值.方法 新生儿出生72 h后,并充分哺乳,采集足跟血滴于专用滤纸上,采用时间分辨荧光免疫分析方法,检测滤纸干血片TSH浓度.结果 测定新生儿足跟血TSH共计30 000例,确定本实验室新生儿TSH切值为9.0 mIU/L.结论 TSH切值为9.0 mIU/L是适合吉林省实际情况的.TSH切值的确定为吉林省今后开展大规模的新生儿CH筛查提供了依据.%Objective To determine cut off value of thyroid stimulating hormone (TSH) for screening of congenital hypothyroidism (CH) of newborn in Jilin province.Methods The foot blood samples were obtained at 72 hours after birth and sufficient breast feeding to detect the content of TSH.Results 30 000 neonates were screened,the cut off value of TSH for screening of congenital hypothyroidism of newborn in Jilin was 9.0 mIU/L.Conclusion The TSH cut off value was adjusted to 9.0 mIU/L.The determination of TSH cut off value provided a basis for screening of congenital hypothyroidism among the newborns in Jilin.

  14. Detection of relevant colonic neoplasms with PET/CT: promising accuracy with minimal CT dose and a standardised PET cut-off

    Luboldt, Wolfgang [Multiorgan Screening Foundation, Frankfurt (Germany); University Hospital Frankfurt, Department of Radiology, Frankfurt am Main (Germany); University Hospital Dresden, Clinic and Policlinic of Nuclear Medicine, Dresden (Germany); Volker, Teresa; Zoephel, Klaus; Kotzerke, Joerg [University Hospital Dresden, Clinic and Policlinic of Nuclear Medicine, Dresden (Germany); Wiedemann, Baerbel [University Hospital Dresden, Institute of Medical Informatics and Biometrics, Dresden (Germany); Wehrmann, Ursula [University Hospital Dresden, Clinic and Policlinic of Surgery, Dresden (Germany); Koch, Arne; Abolmaali, Nasreddin [University Hospital Dresden, Oncoray, Dresden (Germany); Toussaint, Todd; Luboldt, Hans-Joachim [Multiorgan Screening Foundation, Frankfurt (Germany); Middendorp, Markus; Gruenwald, Frank [University Hospital Frankfurt, Department of Nuclear Medicine, Frankfurt (Germany); Aust, Daniela [University Hospital Dresden, Department of Pathology, Dresden (Germany); Vogl, Thomas J. [University Hospital Frankfurt, Department of Radiology, Frankfurt am Main (Germany)

    2010-09-15

    To determine the performance of FDG-PET/CT in the detection of relevant colorectal neoplasms (adenomas {>=}10 mm, with high-grade dysplasia, cancer) in relation to CT dose and contrast administration and to find a PET cut-off. 84 patients, who underwent PET/CT and colonoscopy (n=79)/sigmoidoscopy (n=5) for (79 x 6+5 x 2)=484 colonic segments, were included in a retrospective study. The accuracy of low-dose PET/CT in detecting mass-positive segments was evaluated by ROC analysis by two blinded independent reviewers relative to contrast-enhanced PET/CT. On a per-lesion basis characteristic PET values were tested as cut-offs. Low-dose PET/CT and contrast-enhanced PET/CT provide similar accuracies (area under the curve for the average ROC ratings 0.925 vs. 0.929, respectively). PET demonstrated all carcinomas (n=23) and 83% (30/36) of relevant adenomas. In all carcinomas and adenomas with high-grade dysplasia (n=10) the SUV{sub max} was {>=}5. This cut-off resulted in a better per-segment sensitivity and negative predictive value (NPV) than the average PET/CT reviews (sensitivity: 89% vs. 82%; NPV: 99% vs. 98%). All other tested cut-offs were inferior to the SUV{sub max}. FDG-PET/CT provides promising accuracy for colorectal mass detection. Low dose and lack of iodine contrast in the CT component do not impact the accuracy. The PET cut-off SUV{sub max}{>=} 5 improves the accuracy. (orig.)

  15. Optimal Waist Circumference Cut-Off Point for Multiple Risk Factor Aggregation: Results from the Maracaibo City Metabolic Syndrome Prevalence Study

    Valmore Bermúdez

    2014-01-01

    Full Text Available Context and Objective. The purpose of this study was to determine optimal waist circumference (WC cut-off values for the detection of multiple risk factor aggregation in individuals from Maracaibo, Venezuela. Participants and Methods. A total of 1,902 adult individuals of both genders belonging to MMSPS were included. Complete physical, laboratory, and anthropometric examination were done to evaluate Metabolic Syndrome (MS components and insulin resistance. ROC curves were plotted for risk factor aggregation in order to assess WC cut-off point. Logistic regression models were constructed to assess risk factors associated with the WC. Results. There were 52.2% females and 47.8% males, with WC of 90.7±13.7 cm and 98.2±15.9 cm, respectively. ROC curves exhibited a WC cut-off point for women of 90.25 cm (68.4% sensitivity, 65.8% specificity and 95.15 cm (71.1% sensitivity, 67.4% specificity for men. HOMA2-IR and high blood pressure were associated with a WC over these cut-off points, as well as 2.5-fold risk increase for multiple risk factor aggregation (OR 2.56; CI 95%: 2.05–3.20; P<0.01. Conclusions. These population-specific WC cut-offs are readily applicable tools for detection of risk factor aggregation. Insulin resistance is closely associated with this definition of abdominal obesity, which may serve as a surrogate for its assessment.

  16. Investigation of the performance of cement-bentonite cut-off walls in aggressive ground at a disused gasworks site

    There has been an increased use of cement-bentonite slurry trench cut-off walls to control the lateral migration of pollution in the UK. Concerns inevitably exist about their performance in chemically aggressive ground particularly in the long term. To address some of the uncertainties a programme of field and laboratory research is being undertaken at a disused gasworks in the UK. Elevated levels of sulphate and other contaminants are present on the site and could potentially change the properties of the cement-bentonite. Two boxes, 10m square in plan, by 5m deep have been constructed, one with and one without an HDPE membrane, to isolate parts of the site. Local hydraulic gradients across the walls have been created by pumping from within the boxes. Isolated lengths of wall have been constructed which are being used to assess and develop in-situ testing techniques such as the piezocone for measuring permeability, strength and overall integrity of the wall

  17. On a holographic dark energy model with a Nojiri-Odintsov cut-off in general relativity

    Khurshudyan, Martiros

    2016-07-01

    In this paper we consider the models of the accelerated expanding large scale universe (according to general relativity) containing a generalized holographic dark energy with a Nojiri-Odintsov cut-off. The second component of the darkness is assumed to be the pressureless cold dark matter according to observed symmetries of the large scale universe. Moreover, we assume specific forms of the interaction between these two components and besides the cosmographic analysis, we discuss appropriate results from Om and Om3 analysis and organize a closer look to the models via the statefinder hierarchy analysis, too. In this way we study mainly impact of the interaction on the dynamics of the background of our universe (within specific forms of interaction). To complete the cosmographic analysis, the present day values of the statefinder parameters (r,s) and (ω^'_{de}, ω_{de}) has been estimated for all cases and the validity of the generalized second law of thermodynamics is demonstrated. Our study showed that theoretical results from considered phenomenological models are consistent with the available observational data and symmetries.

  18. Collector optimization for tradeoff between breakdown voltage and cut-off frequency in SiGe HBT

    As is well known, there exists a tradeoff between the breakdown voltage BVCEO and the cut-off frequency fT for a standard heterojunction bipolar transistor (HBT). In this paper, this tradeoff is alleviated by collector doping engineering in the SiGe HBT by utilizing a novel composite of P+ and N− doping layers inside the collector-base (CB) space-charge region (SCR). Compared with the single N-type collector, the introduction of the thin P+ layers provides a reverse electric field weakening the electric field near the CB metallurgical junction without changing the field direction, and the thin N− layer further effectively lowers the electric field near the CB metallurgical junction. As a result, the electron temperature near the CB metallurgical junction is lowered, consequently suppressing the impact ionization, thus BVCEO is improved with a slight degradation in fT. The results show that the product of fT × BVCEO is improved from 309.51 GHz·V to 326.35 GHz·V. (electromagnetism, optics, acoustics, heat transfer, classical mechanics, and fluid dynamics)

  19. Antimicrobial susceptibility testing of Clostridium difficile using EUCAST epidemiological cut-off values and disk diffusion correlates.

    Erikstrup, L T; Danielsen, T K L; Hall, V; Olsen, K E P; Kristensen, B; Kahlmeter, G; Fuursted, K; Justesen, U S

    2012-08-01

    With the emergence of reduced susceptibility of Clostridium difficile to metronidazole and vancomycin the value of antimicrobial susceptibility testing has increased. The aim of our study was to evaluate disk diffusion for susceptibility testing of C. difficile by comparing disk diffusion results with MICs from gradient tests and to propose zone diameter breakpoint correlates for the EUCAST epidemiological cut-off values (ECOFFs) recently published. We tested 211 clinical isolates of C. difficile, from patients with diarrhoea hospitalized at Aarhus and Odense University Hospitals, Denmark. Furthermore, ten clinical isolates of C. difficile from the Anaerobe Reference Laboratory, University Hospital of Wales, with known reduced susceptibility to either metronidazole or vancomycin, were included. Isolates were tested with Etest gradient strips and disk diffusion towards metronidazole, vancomycin and moxifloxacin on Brucella Blood Agar supplemented with hemin and vitamin K. We found an excellent agreement between inhibition zone diameter and MICs. For each MIC value, the inhibition zones varied from 0 to 8 mm, with 93% of values within 6 mm for metronidazole, 95% of values within 4 mm for vancomycin, and 98% of values within 4 mm for moxifloxacin. With proposed zone diameter breakpoints for metronidazole, vancomycin and moxifloxacin of WT ≥ 23 mm, WT ≥ 19 and WT ≥ 20 mm, respectively, we found no very major errors and only major errors below 2%. In conclusion, we suggest that disk diffusion is an option for antimicrobial susceptibility testing of C. difficile. PMID:22672504

  20. High-speed video of competing and cut-off leaders prior to "upward illumination-type" lightning ground strokes

    Stolzenburg, Maribeth; Marshall, Thomas; Karunarathne, Sumedhe; Karunarathna, Nadeeka; Warner, Tom; Orville, Richard

    2013-04-01

    This study presents evidence to test a hypothesis regarding the physical mechanism resulting in very weak "upward illumination" (UI) type ground strokes occurring within a few milliseconds after a normal return stroke (RS) of a negative lightning flash. As described in previous work [Stolzenburg et al., JGR D15203, 2012], these short duration (strokes form a new ground connection, without apparent connection to the main RS, over their relatively short (strokes averages -5.0 kA, about one-third the average value for the preceding RS. In 15 cases the video data show a distinct stepped leader to the UI which develops concurrently with the stepped leader to the main RS. Estimated altitude of the UI leader tip just before the main RS occurs ranges from 0 to 610 m, and in 7 cases steps are visible in the UI leader after the main RS. In most of the examples the RS and UI appear as separate channels for their entire visible portion, but in 5 cases there is a junction indicating the UI leader is a cut-off branch from the main leader. A generalized schematic of the seven main luminosity stages in a typical UI, along with video examples showing each of these stages and electric field change data, will be presented.

  1. Traveling Wave MRI at 21.1 T: Propagation below Cut-off for Ultrahigh Field Vertical Bore System

    Tonyushkin, Alexey A; Grant, Samuel C; Kiruluta, Andrew JM

    2014-01-01

    At high magnetic field strengths (> 4 T), the propagation wave vector of the excitation field B1 can no longer be ignored as the wavelength becomes commensurate or smaller than the imaging field of view (FOV), particularly for high dielectric media. The emergence of this propagation wave vector renders the excitation field variant in both time and space. In this paper, the propagation of RF excitation waves in a high field vertical NMR system is demonstrated for the first time with an appropriate screened dielectric waveguide excited by a simple loop coil to enable below cutoff propagation for imaging in the far field. Uniquely, aqueous samples provide the high permittivity required to modify the cut-off requirements of this transmission system. Theory and simulations corroborate the observed propagating modes field patterns. The ease of construction and implementation of this setup permits use in a variety of high field systems. At a minimum, this design provides a larger FOV that is limited primarily by the...

  2. On the newtonian limit and cut--off scales of isothermal dark matter halos with cosmological constant

    Sussman, R A; Sussman, Roberto A.; Hernandez, Xavier

    2003-01-01

    We examine isothermal dark matter halos in hydrostatic equilibrium with a cosmological constant Lambda =Omega_\\Lambda rho_{crit}c^2, where Omega_\\Lambda=0.7, and rho_{crit} is the present value of the critical density with h=0.65. The Newtonian limit of General Relativity yields equilibrium equations that are different from those arising by merely coupling an ``isothermal sphere'' to the Lambda-field within a Newtonian framework. The conditions for the existence and stability of circular geodesic orbits show the existence of (I) an ``isothermal region'' (0r_1) dominated by the Lambda-field, where the Newtonian potential oscillates and circular orbits exist in disconnected patches of the domain of r; (III) a ``transition region'' (r_20.008 M_\\odot {pc}^3, in agreement with rotation curve studies of dwarf galaxies. Since r_2 marks the largest radius of a stable circular orbit, it provides a ``cut off'' radius. For current estimates of rho_c and velocity dispersion of galactic structures, this is around five tim...

  3. Large D-Dimer Fluctuation in Normal Pregnancy: A Longitudinal Cohort Study of 4,117 Samples from 714 Healthy Danish Women

    Hedengran, Katrine K.; Malene R Andersen; Steen Stender; Pal B. Szecsi

    2016-01-01

    Introduction. D-dimer levels increase throughout pregnancy, hampering the usefulness of the conventional threshold for dismissing thromboembolism. This study investigates the biological fluctuation of D-dimer in normal pregnancy. Methods. A total of 801 healthy women with expected normal pregnancies were recruited. D-dimer was repeatedly measured during pregnancy, at active labor, and on the first and second postpartum days. Percentiles for each gestational week were calculated. Each individu...

  4. Ratchet rotation of a 3D dimer on a vibrating plate.

    Wang, Jiao; Liu, Caishan; Jia, Yan-Bin; Ma, Daolin

    2014-01-01

    This work studies the dynamics of a 3D dimer bouncing upon a horizontal plate undergoing a vertical harmonic vibration. Despite complex interactions within the system due to impacts and friction, numerical simulation shows that, under certain conditions prescribed for the dynamics, the center of mass of the dimer, when projected onto a horizontal plane, will follow a circular orbit. The phenomenon is like a particle under Coulomb friction performing a ratchet motion that rotates around. Investigations further reveal that the dimer dynamics bear some typical characteristics of a nonlinear system, including sensitivity to the initial conditions and bifurcation behaviors related to the physical parameters of the dynamics. Our results indicate that the coefficient of restitution and the plate's vibration intensity play critical roles in exciting the circular orbit, while the dimer's geometry and the vibration frequency mainly influence the trajectory characteristics. These findings may help understand transport mechanisms underlying systems of granular matter with anisotropic particles. PMID:24458553

  5. Values of the Wells and Revised Geneva Scores Combined with D-dimer in Diagnosing Elderly Pulmonary Embolism Patients

    Dan-Jie Guo

    2015-01-01

    Full Text Available Background: Pulmonary embolism (PE can be difficult to diagnose in elderly patients because of the coexistent diseases and the combination of drugs that they have taken. We aimed to compare the clinical diagnostic values of the Wells score, the revised Geneva score and each of them combined with D-dimer for suspected PE in elderly patients. Methods: Three hundred and thirty-six patients who were admitted for suspected PE were enrolled retrospectively and divided into two groups based on age (≥65 or <65 years old. The Wells and revised Geneva scores were applied to evaluate the clinical probability of PE, and the positive predictive values of both scores were calculated using computed tomography pulmonary arteriography as a gold standard; overall accuracy was evaluated by the area under the curve (AUC of receiver operator characteristic curve; the negative predictive values of D-dimer, the Wells score combined with D-dimer, and the revised Geneva score combined with D-dimer were calculated. Results: Ninety-six cases (28.6% were definitely diagnosed as PE among 336 cases, among them 56 cases (58.3% were ≥65 years old. The positive predictive values of Wells and revised Geneva scores were 65.8% and 32.4%, respectively (P < 0.05 in the elderly patients; the AUC for the Wells score and the revised Geneva score in elderly was 0.682 (95% confidence interval [CI]: 0.612-0.746 and 0.655 (95% CI: 0.584-0.722, respectively (P = 0.389. The negative predictive values of D-dimer, the Wells score combined with D-dimer, and the revised Geneva score combined with D-dimer were 93.7%, 100%, and 100% in the elderly, respectively. Conclusions: The diagnostic value of the Wells score was higher than the revised Geneva score for the elderly cases with suspected PE. The combination of either the Wells score or the revised Geneva score with a normal D-dimer concentration is a safe strategy to rule out PE.

  6. The value of blood D-dimer test in the diagnosis of walk-in patients with venous thromboembolism

    Shozo Yasuoka

    2011-03-01

    Full Text Available Shozo Yasuoka, Shunichiro KubotaYasuoka Clinic, Musashino City, Tokyo, JapanAbstract: Venous thromboembolism (VTE and related pulmonary thromboembolism are life-threatening diseases that require efficient diagnosis and clinical management. While the diagnosis and treatment of VTE in hospitalized patients has been extensively studied, less has been reported on walk-in patients with VTE. Here we report on four outpatients with VTE that were efficiently diagnosed using the blood D-dimer test and successfully treated.Keywords: venous thromboembolism, pulmonary thromboembolism, blood D-dimer test

  7. Adjustable collimator

    In a rotating fan beam tomographic scanner there is included an adjustable collimator and shutter assembly. The assembly includes a fan angle collimation cylinder having a plurality of different length slots through which the beam may pass for adjusting the fan angle of the beam. It also includes a beam thickness cylinder having a plurality of slots of different widths for adjusting the thickness of the beam. Further, some of the slots have filter materials mounted therein so that the operator may select from a plurality of filters. Also disclosed is a servo motor system which allows the operator to select the desired fan angle, beam thickness and filter from a remote location. An additional feature is a failsafe shutter assembly which includes a spring biased shutter cylinder mounted in the collimation cylinders. The servo motor control circuit checks several system conditions before the shutter is rendered openable. Further, the circuit cuts off the radiation if the shutter fails to open or close properly. A still further feature is a reference radiation intensity monitor which includes a tuning-fork shaped light conducting element having a scintillation crystal mounted on each tine. The monitor is placed adjacent the collimator between it and the source with the pair of crystals to either side of the fan beam

  8. Effect of Body Mass Index on All-cause Mortality and Incidence of Cardiovascular Diseases - Report for Meta-Analysis of Prospective Studies on Optimal Cut-off Points of Body Mass Index in Chinese Adults

    2002-01-01

    Objective To verify the optimal cut-off points for overweight and obesity in Chinese adults based on the relationship of baseline body mass index (BMI) to all-cause mortality, and incidence of cardiovascular diseases from pooled data of Chinese cohorts. Methods The prospective study data of existing cohort studies in China were collected, and the age-adjusted all-cause mortality stratified by BMI were estimated. The similar analysis was repeated after excluding deaths within the first three years of follow-up and after excluding smokers. The incidence of age-adjusted coronary heart disease (CHD) and stroke stratified by BMI were also analyzed. Multiple Cox regression coefficients of BMI for the incidence of CHD and stroke after controlling other risk factors were pooled utilizing the methods of weighting by inverse of variance to reveal whether BMI had independent effect and its strength on the incidence of CHD and stroke. Results The data of 4 cohorts including 76 227persons, with 745 346 person-years of follow-up were collected and analyzed. The age-adjusted allcause mortality stratified by BMI showed a U-shaped curve, even after excluding deaths within the first three years of follow-up and excluding smokers. Age-adjusted all-cause mortality increased when BMI was lower than 18.5 and higher than 28. The incidence of CHD and stroke, especially ishemic stroke increased with increasing BMI, this was consistent with parallel increasing of risk factors. Cox regression analysis showed that BMI was an independent risk factor for both CHD and stroke. Each amount of 2 kg/m2 increase in baseline BMI might cause 15.4%, 6.1% and 18.8 % increase in relative risk of CHD, total stroke and ischemic stroke. Reduction of BMI to under 24 might prevent the incidence of CHD by 11% and that of stroke by15 % for men, and 22 % of both diseases for women. Conclusion BMI ≤18.5, 24-27.9 and ≥28 (kg/m2) is the appropriate cut-off points for underweight, overweight and obesity in

  9. Cut-Off Levels of Anti-Mullerian Hormone for The Prediction of Ovarian Response, In Vitro Fertilization Outcome and Ovarian Hyperstimulation Syndrome

    Ali Salmassi

    2015-07-01

    Full Text Available Background: Evaluation of anti-mullerian hormone (AMH cut-off levels in assisted reproductive technology (ART as predictive factor for individualization of stimulation protocols and to avoid ovarian hyperstimulation syndrome (OHSS. Materials and Methods: In a retrospective study, 177 infertile patients were assessed for AMH in serum and follicular fluid (FF on the day of follicular puncture (FP, between 2012 and 2013 in Kiel, Germany. AMH levels and pregnancy rates were compared between low, moderate and high responders and cut-off levels of low and high responders. AMH cut-off levels in pathological cases were evaluated in analysis 1 (OHSS and in analysis 2 [polycystic ovarian syndrome, (PCOS] and compared in analysis 3 to normal endocrinological parameters. Results: AMH levels in FF were higher than in serum (P<0.001. AMH levels in serum and FF increased from low through moderate to high responders (P<0.001. Pregnancy rates were 14.7, 23.3 and 44.9% (P=0.009, respectively. AMH cut-off level for poor responders was 0.61 ng/ml in serum with a pregnancy rate of 13.8 and 37.1% for below and above of this level, respectively. For FF, it was 1.43 ng/ml. AMH levels in analysis 1 and 2 were significantly higher than in analysis 3 (P=0.001. AMH cut-off level for OHSS was 1.5 ng/ml in serum with OHSS rates of 80.8 and 19.2 % for above and below of the level, respectively. For FF, it was 2.7 ng/ml. PCOS patients had an AMH cut-off level of 3.9 ng/ml in serum and 6.8 ng/ml in FF, resulting in a PCOS rate of 100% above this level. Conclusion: AMH levels can help to assess ovarian response potential and guide ovarian stimulation while avoiding OHSS.

  10. Combined Effect of an Atmospheric River and a Cut-off Low in Hiroshima Flooding Event on August 19, 2014

    Takayabu, Y. N.; Hirota, N.; Kato, M.; Arakane, S.

    2015-12-01

    An extraordinary precipitation over 100 mmhr-1in Hiroshima on August 19, 2014, caused a flash flood which resulted in 74 fatalities and collapse of 330 houses. In order to examine the meteorological background of this flooding event, we carried out a detailed analysis utilizing rain gauge data, satellite precipitation dataset, and a meso scale and a global scale objective analyses provided from the Japan Meteorological Agency. Then, we performed numerical experiments using a nonhydrostatic compressible equation model called the Cloud-Resolving Storm Simulator (CReSS). As a result, a combined effect of an atmospheric river (AR) and a cut-off low (COL) in this flooding event was elucidated. During the event, a filamentary transport of moisture extending from the Indochina Peninsula to the Japanese Islands was observed along the southern side of the subtropical jet, forming an AR. This AR had a deep structure with an amount of free tropospheric moisture comparable to that of the boundary layer. Concurrently, there was a COL, detached from the Mid-Pacific Trough, moving northwestward toward the Japanese Archipelago. With various sensitivity experiments, we concluded that a mid-tropospheric instability associated with the cold core of the COL and a dynamical ascent induced in its foreside, collaboratively worked with the anomalous moisture in the free troposphere associated with the AR, to extraordinarily enhance the precipitation over Hiroshima region. An orographic effect to concentrate the precipitation in this region was also confirmed. An implication on a difference in effects of AR in this event with a climatologically moist boundary layer, from those in the US west coast with a very dry environment, was also obtained. Acknowledgment: This study is supported by the Environment Research and Technology Development Fund (2-1503) of the Ministry of the Environment, Japan, and by the Ministry of Education, Culture, Sports, Science and Technology, Japan.

  11. Normal D-dimer ved dyb venøs trombose i en overekstremitet hos to patienter med pacemaker

    Byrne, Christina; Abdulla, Jawdat; Christensen, Jan Kim

    2015-01-01

    Danish guidelines recommend the use of D-dimer to exclude deep venous thrombosis (DVT) in the lower extremities. However, guidelines are lacking for DVT in the upper extremities. We describe two young women with transvenous pacemaker electrodes and symptomatic DVT in related veins. Despite a norm...

  12. Comparative study of food transfers in the three castes of the honeybee (Apis mellifica ligustica S.) in which four distal sections of both antennae have been cut off

    The study of food transfers between the three castes of Apis mellifica ligustica S., in which four distal sections have been cut off, has been carried out by means of a radioactive tracer 198Au, which cannot be metabolized. The begging behavior of queens with cut off antennae towards 4-day-old worker Bees and workers of unknown age is not changed. So it is with drones and operated worker Bees which beg food of a worker Bee, that is 4 days old and undamaged. On the other hand the begging behavior of drones and workers of unknown age is reduced towards other worker Bees of unknown age that are undamaged. The two-sided amputation of antennal sections of donor worker Bees of both categories does not change their behavior towards undamaged worker Bees

  13. Interacting power-law and logarithmic entropy-corrected holographic dark energy models with different cut-offs in Brans-Dicke cosmology

    Darabi, F.; Felegary, F.

    2015-01-01

    In the framework of Brans-Dicke cosmology, we have studied the interacting power-law and logarithmic entropy-corrected holographic dark energy models with different cut-offs. The Brans-Dicke parameter is investigated versus the conditions for the acceleration and phantom phases to show that which entropy corrected model can exhibit acceleration with or without the phantom phase at early and present time universes. Moreover, the classical stability or instability of the interacting power-law a...

  14. High cut-off value of a chimeric TSH receptor (Mc4)-based bioassay may improve prediction of relapse in Graves' disease for 12 months.

    Hwang, Sena; Shin, Dong Yeob; Song, Mi Kyung; Lee, Eun Jig

    2015-02-01

    There are scarce reports regarding a functional prognostic value of thyroid-stimulating autoantibody (TSAb) levels using a thyroid-stimulating hormone receptor chimera (Mc4) in Graves' disease (GD) in iodine sufficient area. The aim of this study was to investigate whether Mc4-TSAb can predict GD remission/relapse after antithyroid drug (ATD) treatment and to compare Mc4-TSAb with a binding assay using M22 monoclonal antibody (M22-TRAb) in GD patients. We retrospectively reviewed the results of M22-TRAb and Mc4-TSAb in GD patients treated with ATD for 12 months. GD patients who underwent ATD treatment for at least 12 months were included. We compared the predictive values of M22-TRAb and Mc4-TSAb for GD remission and relapse. Of the 92 patients, 60 (65.2%) achieved remission and 32 (34.8%) relapsed within 12 months. In receiver operating characteristic analysis, there were no significant differences in the area under the curves (AUCs) between Mc4-TSAb [AUC=0.79 (95% CI 0.69-0.89)] and M22-TRAb [AUC=0.69 (95% CI 0.58-0.81)]. The optimal predictive cut-off values of M22-TRAb and Mc4-TSAb were 2.23 IU/L and 230%, respectively. At a high Mc4-TSAb cut-off, the better specificity of 85.0% and positive predictive value (PPV) of 69.0% were shown compared with those at the best cut-off for M22-TRAb. In conclusion, a high cut-off for an Mc4 assay may improve the predictive value of relapse with superior specificity and PPV compared with M22-TRAb in treated GD. PMID:24968734

  15. Addenbrooke’s Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson’s Disease

    Dagmar Berankova

    2015-01-01

    Full Text Available Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke’s Cognitive Examination-Revised (ACE-R in discriminating between Parkinson’s disease (PD with normal cognition (PD-NC and PD with mild cognitive impairment (PD-MCI and between PD-MCI and PD with dementia (PD-D. We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests. Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91; ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73. The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73 while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97. ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.

  16. Cut-off scores for the Minimal Eating Observation and Nutrition Form – Version II (MEONF-II) among hospital inpatients

    Westergren, Albert; Norberg, Erika; Vallén, Christina; Hagell, Peter

    2011-01-01

    Background and objective: The newly developed Minimal Eating Observation and Nutrition Form - Version II (MEONF-II) has shown promising sensitivity and specificity in relation to the Mini Nutritional Assessment (MNA). However, the suggested MEONF-II cut-off scores for deciding low/moderate and high risk for undernutrition (UN) (>2 and >4, respectively) have not been decided based on statistical criteria but on clinical reasoning. The objective of this study was to identify the optimal c...

  17. Optimal Ki67 cut-off for luminal breast cancer prognostic evaluation: a large case series study with a long-term follow-up.

    Bustreo, Sara; Osella-Abate, Simona; Cassoni, Paola; Donadio, Michela; Airoldi, Mario; Pedani, Fulvia; Papotti, Mauro; Sapino, Anna; Castellano, Isabella

    2016-06-01

    Although Ki67 index suffers from poor reproducibility, it is one of the most important prognostic markers used by oncologists to select the treatment of estrogen receptor (ER) positive breast cancer patients. In this study, we aim to establish the optimal Ki67 cut-offs for stratifying patient prognosis and to create a comprehensive prognostic index for clinical applications. A mono-institutional cohort of 1.577 human epidermal growth factor receptor 2 negative/ER+ breast cancer patients having complete clinical, histological, and follow-up data was collected. The 14 and 20 % Ki67 cut-offs were correlated to disease-free interval (DFI) and disease-specific survival (DSS). To create a comprehensive prognostic index, we used independent variables selected by uni/multivariate analyses. In terms of DFI and DSS, patients bearing tumors with Ki67  20 % showed the poorest prognosis. Moreover, to tumor size, the number of metastatic lymph nodes and Ki67 > 20 % was given a score value, varying depending on definite cut-offs and used to create a prognostic index, which was applied to the population. Patients with a prognostic index ≥3 were characterized by significant risk of relapse [DFI: Hazard Ratio (HR) = 4.74, p < 0.001] and death (DSS: HR = 5.03, p < 0.001). We confirm that the 20 % Ki67 cut-off is the best to stratify high-risk patients in luminal breast cancers, and we suggest to integrate it with other prognostic factors, to better stratify patients at risk of adverse outcome. PMID:27155668

  18. Serological diagnosis of pneumococcal infection in children with pneumonia using protein antigens: A study of cut-offs with positive and negative controls.

    Andrade, Dafne Carvalho; Borges, Igor Carmo; Ivaska, Lauri; Peltola, Ville; Meinke, Andreas; Barral, Aldina; Käyhty, Helena; Ruuskanen, Olli; Nascimento-Carvalho, Cristiana Maria

    2016-06-01

    The etiological diagnosis of infection by Streptococcus pneumoniae in children is difficult, and the use of indirect techniques is frequently warranted. We aimed to study the use of pneumococcal proteins for the serological diagnosis of pneumococcal infection in children with pneumonia. We analyzed paired serum samples from 13 Brazilian children with invasive pneumococcal pneumonia (positive control group) and 23 Finnish children with viral pharyngitis (negative control group), all aged pharyngitis were evaluated for oropharyngeal colonization, and none of them carried S. pneumoniae. We used a multiplex bead-based assay with eight proteins: Ply, CbpA, PspA1 and 2, PcpA, PhtD, StkP and PcsB. The optimal cut-off for increase in antibody level for the diagnosis of pneumococcal infection was determined for each antigen by ROC curve analysis. The positive control group had a significantly higher rate of ≥2-fold rise in antibody levels against all pneumococcal proteins, except Ply, compared to the negative controls. The cut-off of ≥2-fold increase in antibody levels was accurate for pneumococcal infection diagnosis for all investigated antigens. However, there was a substantial increase in the accuracy of the test with a cut-off of ≥1.52-fold rise in antibody levels for PcpA. When using the investigated protein antigens for the diagnosis of pneumococcal infection, the detection of response against at least one antigen was highly sensitive (92.31%) and specific (91.30%). The use of serology with pneumococcal proteins is a promising method for the diagnosis of pneumococcal infection in children with pneumonia. The use of a ≥2-fold increase cut-off is adequate for most pneumococcal proteins. PMID:26928648

  19. Waist circumference cut-off values for the prediction of cardiovascular risk factors clustering in Chinese school-aged children: a cross-sectional study

    Xu Ying

    2010-02-01

    Full Text Available Abstract Background Waist circumference has been identified as a valuable predictor of cardiovascular risk in children. The development of waist circumference percentiles and cut-offs for various ethnic groups are necessary because of differences in body composition. The purpose of this study was to develop waist circumference percentiles for Chinese children and to explore optimal waist circumference cut-off values for predicting cardiovascular risk factors clustering in this population. Methods Height, weight, and waist circumference were measured in 5529 children (2830 boys and 2699 girls aged 6-12 years randomly selected from southern and northern China. Blood pressure, fasting triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glucose were obtained in a subsample (n = 1845. Smoothed percentile curves were produced using the LMS method. Receiver-operating characteristic analysis was used to derive the optimal age- and gender-specific waist circumference thresholds for predicting the clustering of cardiovascular risk factors. Results Gender-specific waist circumference percentiles were constructed. The waist circumference thresholds were at the 90th and 84th percentiles for Chinese boys and girls respectively, with sensitivity and specificity ranging from 67% to 83%. The odds ratio of a clustering of cardiovascular risk factors among boys and girls with a higher value than cut-off points was 10.349 (95% confidence interval 4.466 to 23.979 and 8.084 (95% confidence interval 3.147 to 20.767 compared with their counterparts. Conclusions Percentile curves for waist circumference of Chinese children are provided. The cut-off point for waist circumference to predict cardiovascular risk factors clustering is at the 90th and 84th percentiles for Chinese boys and girls, respectively.

  20. Cerebrospinal fluid neopterin analysis in neuropediatric patients: establishment of a new cut off-value for the identification of inflammatory-immune mediated processes.

    Marta Molero-Luis

    Full Text Available OBJECTIVE: A high level of cerebrospinal fluid (CSF neopterin is a marker of central nervous system inflammatory-immune mediated processes. We aimed to assess data from 606 neuropediatric patients, describing the clinical and biochemical features of those neurological disorders presenting CSF neopterin values above a new cut-off value that was defined in our laboratory. METHODS: To establish the new CSF neopterin cut-off value, we studied two groups of patients: Group 1 comprised 68 patients with meningoencephalitis, and Group 2 comprised 52 children with a confirmed peripheral infection and no central nervous system involvement. We studied 606 CSF samples from neuropediatric patients who were classified into 3 groups: genetic diagnosis (A, acquired/unknown etiologic neurologic diseases (B and inflammatory-immune mediated processes (C. RESULTS: The CSF neopterin cut-off value was 61 nmol/L. Out of 606 cases, 56 presented a CSF neopterin level above this value. Group C had significantly higher CSF neopterin, protein and leukocyte values than the other groups. Sixteen of twenty-three patients in this group had a CSF neopterin level above the cut-off, whereas three and seven patients presented increased leukocyte and protein values, respectively. A significant association was found among CSF neopterin, proteins and leukocytes in the 606 patients. White matter disturbances were associated with high CSF neopterin concentrations. CONCLUSIONS: Although children with inflammatory-immune mediated processes presented higher CSF neopterin values, patients with other neurological disorders also showed increased CSF neopterin concentrations. These results stress the importance of CSF neopterin analysis for the identification of inflammatory-immune mediated processes.

  1. CA-125 cut-off value as a predictor for complete interval debulking surgery after neoadjuvant chemotherapy in patients with advanced ovarian cancer

    Furukawa, Naoto; Sasaki, Yoshikazu; Shigemitsu, Aiko; AKASAKA, JURIA; Kanayama, Seiji; Kawaguchi, Ryuji; Kobayashi, Hiroshi

    2013-01-01

    Objective In the present study, we evaluated changes in CA-125 cut-off values predictive of complete interval debulking surgery (IDS) after neoadjuvant chemotherapy (NAC) using receiver operating characteristic (ROC) analysis. Methods This retrospective single-institution study included patients with International Federation of Gynecology and Obstetrics (FIGO) stage III epithelial ovarian cancer and a pre-NAC serum CA-125 level of greater than 40 U/mL who were treated with neoadjuvant platinu...

  2. Optimal Cut-Off Points for Two-Step Strategy in Screening of Undiagnosed Diabetes: A Population-Based Study in China

    Ye, Zhen; Cong, Liming; Ding, Gangqiang; Yu, Min; Zhang, Xinwei; Hu, Ruying; Wu, Jianjun; Fang, Le; Wang, Hao; Zhang, Jie; He, Qingfang; Su, Danting; Zhao, Ming; Wang, Lixin; GONG, WEIWEI

    2014-01-01

    To identify optimal cut-off points of fasting plasma glucose for two-step strategy in screening of undiagnosed diabetes in Chinese people, data were selected from two cross-sectional studies of Metabolic Syndrome in Zhejiang Province of China, Zhejiang Statistical Yearbook (2010), and published literatures. Two-step strategy was used among 17437 subjects sampled from population to screen undiagnosed diabetes. Effectiveness (proportion of cases identified), costs (including medical and non-med...

  3. Plasma level of D-dimer accompanying different types of gynecologic surgery and effects of prophylactic subcutaneous injection of heparin calcium

    Sakika Yanai

    2015-06-01

    Conclusions: Plasma levels of D-dimer on POD-1 were higher than those on the DPE in each type of gynecologic surgery. The D-dimer level remained high even on POD-6, and not changed by prophylactic subcutaneous injection of heparin calcium. [Int J Reprod Contracept Obstet Gynecol 2015; 4(3.000: 551-554

  4. Optimal Elasticity cut-off value for discriminating Healthy to Pathological Fibrotic patients employing Fuzzy C-Means automatic segmentation in Liver Shear Wave Elastography images

    Gatos, Ilias; Tsantis, Stavros; Skouroliakou, Aikaterini; Theotokas, Ioannis; Zoumpoulis, Pavlos S.; Kagadis, George C.

    2015-09-01

    The aim of the present study is to determine an optimal elasticity cut-off value for discriminating Healthy from Pathological fibrotic patients by means of Fuzzy C-Means automatic segmentation and maximum participation cluster mean value employment in Shear Wave Elastography (SWE) images. The clinical dataset comprised 32 subjects (16 Healthy and 16 histological or Fibroscan verified Chronic Liver Disease). An experienced Radiologist performed SWE measurement placing a region of interest (ROI) on each subject's right liver lobe providing a SWE image for each patient. Subsequently Fuzzy C-Means clustering was performed on every SWE image utilizing 5 clusters. Mean Stiffness value and pixels number of each cluster were calculated. The mean stiffness value feature of the cluster with maximum pixels number was then fed as input for ROC analysis. The selected Mean Stiffness value feature an Area Under the Curve (AUC) of 0.8633 with Optimum Cut-off value of 7.5 kPa with sensitivity and specificity values of 0.8438 and 0.875 and balanced accuracy of 0.8594. Examiner's classification measurements exhibited sensitivity, specificity and balanced accuracy value of 0.8125 with 7.1 kPa cutoff value. A new promising automatic algorithm was implemented with more objective criteria of defining optimum elasticity cut-off values for discriminating fibrosis stages for SWE. More subjects are needed in order to define if this algorithm is an objective tool to outperform manual ROI selection.

  5. Excitation energy and angular momentum dependence of nuclear level densities and spin cut-off factor in SPA and SPA + RPA approaches

    We investigate the excitation energy (E*) and angular momentum (J) dependence of nuclear level density and spin cut-off factor (σ) within microscopic approaches based on SPA and its extension SPA+RPA representation of the grand partition function for quadrupole-quadrupole interaction model Hamiltonian. For 110Sn, we find that excitation energy dependence of the total level density obtained within these approaches is significantly different. On the other hand, these approaches yield similar behaviour for J-dependence of the level density at fixed values of E*. Values of σSPA+RPA at low E* are found to be slightly smaller than σSPA but they tend to become almost the same at higher E* (>30 MeV). We also find that Bethe's formula for fixed-J level density based on the spin cut-off approximation can be used to compute ρ(E*,J) near the yrast line provided one uses an appropriate value of the spin cut-off factor. (orig.)

  6. D-D dimer levels in patients with sickle cell disease during bone pain crises and in the steady state

    Fakunle EE

    2012-05-01

    Full Text Available Eyitayo Emmanuel Fakunle,1 Kapoona Iwara Ibiang Eteng,2 Wuraola Adebola Shokunbi21Department of Pathology, King Edward VII Memorial Hospital, Bermuda; 2Department of Hematology, University College Hospital, Ibadan, NigeriaObjective: To determine the presence of ongoing thrombosis by measuring the D-D dimer levels in bone pain crises (BPCs and in the steady state of patients with sickle cell disease, comparing these levels with those in individuals with normal hemoglobin (HbAA in southwest Nigeria.Study design, patients, and methods: The study design involved 38 patients with homozygous sickle cell anemia (HbSS and 78 adults with the HbAA phenotype, seen at the Hematology Day Care and Accident and Emergency units of the University College Hospital, Ibadan, Nigeria. The TintElize kit was used to quantitatively determine human D-D dimer levels in the plasma with enzyme immunoassay.Results: The mean D-D dimer level measured of the 78 individuals with HbAA was 73.59 ng/mL. The mean D-D dimer level of the patients with HbSS during BPCs was 4002.40 ng/mL, while the mean level in the same patients in the steady state measured 6 weeks after their BPCs, with no other painful crisis episode before the sample was collected, was 1320.00 ng/mL.Conclusion: This study demonstrated a significant increase in the D-D dimer levels of patients with HbSS in the steady state, when compared with those of individuals with HbAA of the same age and sex distribution. There was also an approximate threefold increase in the D-D dimer levels in the same patients with HbSS during BPCs. This confirms the activation of coagulation and fibrinolytic systems in patients with HbSS in the steady state, which is further escalated during BPCs. A multicenter study on the use of anticoagulants in BPCs in patients with sickle cell disease is required.Keywords: anticoagulant, dimer, sickle cell disease, BPC, Nigeria, chronic hemolytic anemia

  7. Increased tissue factor, MMP-8, and D-dimer expression in diabetic patients with unstable advanced carotid atherosclerosis

    Jerzy Krupinski

    2007-09-01

    Full Text Available Jerzy Krupinski1,2, Marta M Turu1,2, M Angels Font1, Nesser Ahmed3, Matthew Sullivan3, Ana Luque1,2, Francisco Rubio1, Lina Badimon2, Mark Slevin31Department of Neurology, Stroke Unit, University Hospital of Bellvitge (HUB, Fundacio IDIBELL, Barcelona, Spain; 2Cardiovascular Research Centre, IIBB/CSIC-HSCSP-UAB, Barcelona, Spain; 3School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, United KingdomAbstract: Advanced atherogenesis is characterized by the presence of markers of enhanced prothrombotic capacity, attenuated fibrinolysis, and by clinical conditions associated with defective coagulation. Diabetes may be associated with enhanced lesion instability and atherosclerotic plaque rupture. Plaques obtained from 206 patients undergoing carotid endarterectomy were divided into diabetic (type 2 and nondiabetic and analyzed by Western blotting and immunohistochemistry to detect tissue factor (TF, metalloproteinases (MMP-2, -8, -9, and fibrin/fibrinogen related antigens, and in situ zymography to detect MMP activity. Plasma samples were quantified for TF procoagulant activity, C-reactive protein, fibrinogen and D-dimer. Diabetic and symptomatic patients with hypoechogenic plaques had increased plasma TF activity and D-dimer, compared with those with hyperechogenic plaques (p = 0.03, p = 0.007, respectively. Diabetic, symptomatic patients had higher plasma D-dimer levels than asymptomatic patients (p = 0.03. There was a significant correlation between intramural TF levels and D-dimer in diabetic patients with symptomatic disease (p = 0.001, r2 = 0.4. In diabetic patients, plasma fibrinogen levels were higher in patients with hypoechogenic plaques (p = 0.007. Diabetic patients with ulcerated plaques had higher plasma D-dimer and MMP-8 levels than those with fibrous plaques (p = 0.02, p = 0.01, respectively. This data suggests that currently available circulating markers may be clinically useful to select

  8. Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer

    Salgado, R.; Benoy, I; Weytjens, R; Van Bockstaele, D.; Van Marck, E; Huget, Ph; Hoylaerts, M; Vermeulen, P.; Dirix, L Y

    2002-01-01

    The circulating angiogenic factors vascular endothelial growth factor-A, interleukin-6 and the fibrin D-dimer fragment were measured in the mesenteric vein, the uterine vein, as well as in peripheral venous and arterial samples in 21 randomly selected patients with operable colorectal, ovarian and cervical carcinoma. In addition, immunohistochemistry for vascular endothelial growth factor-A and interleukin-6 was performed on colorectal tumours of such patients. Serum and plasma vascular endot...

  9. Determination of Diastolic Dysfunction Cut-Off Value by Tissue Doppler Imaging in Adults 70 Years of Age or Older: A Comparative Analysis of Pulsed-Wave and Color-Coded Tissue Doppler Imaging

    Baek, Hee-Kyung; Park, Tae-Ho; Park, Sun-Yi; Kim, Jung-Hwan; Seo, Jeong-Min; Kim, Woo-Jae; Nam, Young-Hee; Kim, Moo-Hyun; Kim, Young-Dae

    2011-01-01

    Background and Objectives The cut-off value of diastolic dysfunction by tissue Doppler imaging (TDI) is affected by aging and modalities used (pulsed-wave vs. color-coded). The purpose of this study was to investigate the diastolic function of healthy elderly people and to determine the appropriate cut-off value of diastolic dysfunction in elderly individuals. Subjects and Methods Healthy volunteers (n=76) and patients with hypertension (n=51) aged ≥70 years underwent 2-dimensional and Dopple...

  10. Bovine Tuberculosis in Cattle in the Highlands of Cameroon: Seroprevalence Estimates and Rates of Tuberculin Skin Test Reactors at Modified Cut-Offs

    J. Awah-Ndukum

    2012-01-01

    Full Text Available The aim of this study was to obtain epidemiological estimates of bovine tuberculosis (TB prevalence in cattle in the highlands of Cameroon using two population-based tuberculin skin test (TST surveys in the years 2009 and 2010. However, prior to the TST survey in 2010, blood was collected from already chosen cattle for serological assay. Anti-bovine TB antibodies was detected in 37.17% of tested animals and bovine TB prevalence estimates were 3.59%–7.48%, 8.92%–13.25%, 11.77%–17.26% and 13.14%–18.35% for comparative TST at ≥4 mm, ≥3 mm and ≥2 mm cut-off points and single TST, respectively. The agreement between TST and lateral flow was generally higher in TST positive than in TST negative subjects. The K coefficients were 0.119, 0.234, 0.251 and 0.254 for comparative TST at ≥4 mm, ≥3 mm and ≥2 mm cut-off points and the single TST groups, respectively. Chi square statistics revealed that strong (P48 associations existed between seroprevalence rates and TST reactors. The study suggested that using lateral flow assay and TST at severe interpretations could improve the perception of bovine TB in Cameroon. The importance of defining TST at modified cut-offs and disease status by post-mortem detection and mycobacterial culture of TB lesions in local environments cannot be overemphasised.

  11. Optimal cut-off points on the health anxiety inventory, illness attitude scales and whiteley index to identify severe health anxiety.

    Erik Hedman

    Full Text Available Health anxiety can be viewed as a dimensional phenomenon where severe health anxiety in form of DSM-IV hypochondriasis represents a cut-off where the health anxiety becomes clinically significant. Three of the most reliable and used self-report measures of health anxiety are the Health Anxiety Inventory (HAI, the Illness Attitude Scales (IAS and the Whiteley Index (WI. Identifying the optimal cut-offs for classification of presence of a diagnosis of severe health anxiety on these measures has several advantages in clinical and research settings. The aim of this study was therefore to investigate the HAI, IAS and WI as proximal diagnostic instruments for severe health anxiety defined as DSM-IV hypochondriasis.We investigated sensitivity, specificity and predictive value on the HAI, IAS and WI using a total of 347 adult participants of whom 158 had a diagnosis of severe health anxiety, 97 had obsessive-compulsive disorder and 92 were healthy non-clinical controls. Diagnostic assessments were conducted using the Anxiety Disorder Interview Schedule.Optimal cut-offs for identifying a diagnosis of severe health anxiety was 67 on the HAI, 47 on the IAS, and 5 on the WI. Sensitivity and specificity were high, ranging from 92.6 to 99.4%. Positive and negative predictive values ranged from 91.6 to 99.4% using unadjusted prevalence rates.The HAI, IAS and WI have very good properties as diagnostic indicators of severe health anxiety and can be used as cost-efficient proximal estimates of the diagnosis.

  12. Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China

    ZHOU Hai Cheng; TIAN Hao Ming; JI Qiu He; ZHU Da Long; CHEN Li; GUO Xiao Hui; ZHAO Zhi Gang; Li Qiang; ZHOU Zhi Guang; GE Jia Pu; SHAN Guang Liang; LAI Ya Xin; SHAN Zhong Yan; JIA Wei Ping; YANG Wen Ying; LU Ju Ming; WENG Jian Ping; JI Li Nong; LIU Jie

    2014-01-01

    Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome (MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces (autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation (IDF) criteria and modified IDF criteria. Results The age-standardized prevalence of MetS was 24.2%(22.1%in men and 25.8%in women) and 19.5% (22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6%in men and 7.8%in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity (90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China.

  13. Cut-off points of the visceral adiposity index (VAI identifying a visceral adipose dysfunction associated with cardiometabolic risk in a Caucasian Sicilian population

    Amato Marco C

    2011-10-01

    Full Text Available Abstract Background The Visceral Adiposity Index (VAI is a sex-specific mathematical index, based on Waist Circumference (WC, Body Mass Index (BMI, triglycerides (TG and HDL cholesterol (HDL levels, indirectly expressing visceral adipose function and insulin sensitivity. Our aim was to find the optimal cut-off points of VAI identifying a visceral adipose dysfunction (VAD associated with cardiometabolic risk in a Caucasian Sicilian population. Methods Medical check-up data of 1,764 Primary Care patients (PC patients were retrospectively and cross-sectionally examined using a receiver-operating characteristic (ROC curve to determine appropriate stratified-for-age cut-off of VAI, for the identification of PC patients with Metabolic Syndrome (MetS according to the NCEP-ATP III criteria. The PC patients with higher VAI scores were subdivided into three groups according to VAI tertiles (i.e. PC patients with mild VAD, moderate VAD or severe VAD. Finally, VAD classes were compared to classical cardio- and cerebrovascular risk factors as independent predictors of coronary heart disease and/or myocardial infarction, transient ischemic attack and/or ischemic stroke. Results Moderate and severe VADs proved to be independently associated with cardiovascular events [(OR: 5.35; 95% CI: 1.92-14.87; p = 0.001 and (OR: 7.46; 95% CI: 2.64-21.05; p Conclusions Our study suggests that among Caucasian Sicilian subjects there are clear cut-off points of VAI able to identify a VAD strongly associated with cardiometabolic risk.

  14. High speed tool steel cut off dies made using powder metallurgy techniques; Fabricacion de matrices de corte con aceros rapidos para herramientas mediante metalurgia de polvos

    Talacchia, S.; Amador, J.; Urcola, J. [Escuela Superior de Ingenieros, Universidad de Navarra, San Sebastian (Spain)

    1996-06-01

    The present work summarises the results obtained by compacting water atomized powders of T42 modifed carbon and vanadium, M3/2 and M2 high speed steels. The powders were compacted under complex forms (cut off dies) and sintered under a 90 N{sub 2}-9 H{sub 2}-1 CH{sub 4} industrial atmosphere. Heat treatments in different severity media were performed. hardness of 1,100 HV can be obtained in the case of T42 modified steel. Also, the shrinking of the sintered specimens was study. (Author) 6 refs.

  15. Effect of the magnetospheric DCF and DR current systems of on cosmic ray geomagnetic cut-off rigidities in Forbush effect event periods in June and August 1972

    The effect of magnetospheric DCF and DR current systems on regidity of geomagnetic cut-off of cosmic rays (CR) in the periods of Forbush effect in June and August,1972 is considered. It is shown that magnetospheric CR effects conditioned by DCF and DR current fields are opposite in sign and comparable in value during strong disturbances of solar wind velocity. Belts of the most probable current localization in the process of development and evolution of magnetospheric DR current exist in the distances: 4R3(R3-Earth radius) and GR3 in the June event and about 2R3, 4R3 and GR3 in the August event

  16. Influence of the Lift-Off Effect on the Cut-Off Frequency of the EMAT-Generated Rayleigh Wave Signal

    Pengxing Yi; Kang Zhang; Yahui Li; Xuming Zhang

    2014-01-01

    The electromagnetic acoustic transducer (EMAT), a non-contact NDT tool with large lift-off, is becoming an attractive method for detecting the cracks in the metal parts. However, the lift-off of the transducer has a direct effect on the feature that is used to characterize the defects. A detailed investigation on the relationship between the feature and the lift-off of the EMAT is crucial in the detection process. This paper investigates the lift-off effect on the feature, cut-off frequency o...

  17. Combined use of clinical pre-test probability and D-dimer test in the diagnosis of preoperative deep venous thrombosis in colorectal cancer patients

    Stender, Mogens; Frøkjaer, Jens Brøndum; Hagedorn Nielsen, Tina Sandie; Larsen, Torben Bjerregaard; Lundbye-Christensen, Søren; Elbrønd, Henrik; Thorlacius-Ussing, Ole

    2008-01-01

    clinical pre-test probability (PTP) can be safely used to rule out the tentative diagnosis of DVT in cancer patients. However, the accuracy in colorectal cancer patients is uncertain. This study assessed the diagnostic accuracy of a quantitative D-dimer assay in combination with the PTP score in ruling out...... preoperative DVT in colorectal cancer patients admitted for surgery. Preoperative D-dimer test and compression ultrasonography for DVT were performed in 193 consecutive patients with newly diagnosed colorectal cancer. Diagnostic accuracy indices of the D-dimer test were assessed according to the PTP score. The...... negative predictive value, positive predictive value, sensitivity and specificity were 99% (95% confidence interval (CI), 95-100%), 17% (95% CI, 9-26), 93% (95% CI, 68-100%) and 61% (95% CI, 53-68%), respectively. In conclusion, the combined use of pre-test probability and D-dimer test may be useful in...

  18. Vitamin D, d-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study☆

    Musselwhite, Laura W.; Andrade, Bruno B.; Ellenberg, Susan S.; Tierney, Ann; Belaunzaran-Zamudio, Pablo F.; Rupert, Adam; Lederman, Michael M.; Sanne, Ian; Sierra Madero, Juan G.; Sereti, Irini

    2016-01-01

    To determine the immunological profile most important for IRIS prediction, we evaluated 20 baseline plasma biomarkers in Acquired Immunodeficiency Syndrome (AIDS) patients initiating antiretroviral therapy (ART). Patients were enrolled in a randomized, placebo-controlled ART initiation trial in South Africa and Mexico to test whether maraviroc could prevent IRIS. Participants were classified prospectively as having IRIS within 6 months of ART initiation. Twenty plasma biomarkers were measured at study enrollment for 267 participants. Biomarkers were tested for predicting IRIS with adjustment for covariates chosen through forward stepwise selection. Sixty-two participants developed IRIS and of these 19 were tuberculosis (TB)-IRIS. Baseline levels of vitamin D and higher d-dimer, interferon gamma (IFNγ), and sCD14 were independently associated with risk of IRIS in multivariate analyses. TB-IRIS cases exhibited a distinct biosignature from IRIS related to other pathogens, with increased levels of C-reactive protein (CRP), sCD14, IFNγ, and lower levels of Hb that could be captured by a composite risk score. Elevated markers of Type 1 T helper (Th1) response, monocyte activation, coagulation and low vitamin D were independently associated with IRIS risk. Interventions that decrease immune activation and increase vitamin D levels warrant further study. PMID:26981576

  19. Power-law and Logarithmic Entropy Corrected Holographic Dark Energy Models in Brans-Dicke Cosmology with Granda-Oliveros Cut-Off

    Pasqua, Antonio; Myrzakulov, Ratbay

    2015-01-01

    In this paper, the cosmological implications of the Power Law Entropy Corrected Holographic Dark Energy (PLECHDE) and the Logarithmic Entropy Corrected Holographic Dark Energy (LECHDE) models in the context of Brans-Dicke (BD) cosmology for both non-interacting and interacting DE and Dark Matter (DM) are studied. As the system infrared cut-off, we choose the recently proposed Granda-Oliveros cut-off, which contains a term proportional to the first time derivative of the Hubble parameter and one term proportional to $H^2$, i.e. the Hubble parameter squared. We obtain the expressions of three quantities, i.e. the Equation of State (EoS) parameter $\\omega_D$, the deceleration parameter $q$ and the evolutionary form of the energy density parameter $\\Omega'_D$ of the PLECHDE and LECHDE models in a non-flat Universe for non-interacting and interacting DE and DM as well. Moreover, we investigate the limiting cases corresponding to: a) absence of entropy corrections; b) Einstein's gravity; and c) concomitantly absenc...

  20. Power-Law Entropy-Corrected Holographic Dark Energy in Ho\\v{r}ava-Lifshitz Cosmology with Granda-Oliveros Cut-off

    Pasqua, Antonio; Myrzakulov, Ratbay

    2015-01-01

    In this work, we decided to study the Power Law Entropy Corrected Holographic Dark Energy (PLECHDE) model in the framework of a spatially non-flat Universe and in the framework of Ho\\v{r}ava-Lifshitz cosmology with infrared (IR) cut-off given by recently proposed Granda-Oliveros cut-off which contains one term proportional to the Hubble parameter squared and one proportional to the time derivative of the Hubble parameter. For the two cases corresponding to non-interacting and interacting DE and Dark Matter (DM), we derive the evolutionary form of the energy density of DE, the Equation of State (EoS) parameter $\\omega_D$, the evolutionary form of the fractional energy density $\\Omega_D'$ and the deceleration parameter $q$. Using the parametrization of the EoS parameter $\\omega_D\\left(z\\right)=\\omega_0+\\omega_1 z$, we obtain the expressions of $\\omega_0$ and $\\omega_1$ for both non-interacting and interacting Dark Sectors. We also study the statefinder parameters $\\left\\{ r,s \\right\\}$, the properties of some c...

  1. 截锥形直杆的动力稳定性研究%Research on the dynamic stability of cut-off-cone bar

    夏鹭平

    2001-01-01

    This paper discusses the effect of dynamic stability of cut-off-cone bar under vertical vibration force. The influence of cut-off-cone bar and equal section bar on the dynamic property of bars is analyzed respectively. A theoretical method of analyzing the dynamic stability of bars is presented. Some suggestions are made about reducing the unfavourable effect in practical engineering. The work here may be useful to the dynamic analysis and design in practical engineering.%研究了截锥形直杆在竖向振动力作用下,杆件参数共振和动力稳定性问题,分析了截锥形直杆和等截面直杆对杆件动力性能的影响,提出了一种分析杆件动力稳定性的理论方法,方法简明易用,便于掌握,并提出了在实际工程中减小共振的一些措施,为结构的动力分析与设计提供参考依据。

  2. Influence of the Lift-Off Effect on the Cut-Off Frequency of the EMAT-Generated Rayleigh Wave Signal

    Pengxing Yi

    2014-10-01

    Full Text Available The electromagnetic acoustic transducer (EMAT, a non-contact NDT tool with large lift-off, is becoming an attractive method for detecting the cracks in the metal parts. However, the lift-off of the transducer has a direct effect on the feature that is used to characterize the defects. A detailed investigation on the relationship between the feature and the lift-off of the EMAT is crucial in the detection process. This paper investigates the lift-off effect on the feature, cut-off frequency of EMAT in the Rayleigh wave. The study can be divided into two parts. Firstly, with a multi-field coupling environment, 2-D electromagnetic and wave generation EMAT models are built to simulate the interaction of the Rayleigh wave with the surface crack. Then, the lift-off effect on the cut-off frequency is investigated through simulation and experiment. Compared to the previous studies, it is found that lift-off would cause a negative result when the lift-off varies in the testing process. Besides, the calibration obtained from the tests at a random lift-off value can be used in other tests with any different lift off value provided that the lift-off is kept as a constant during the detection process.

  3. Analysis of the acoustic cut-off frequency and high-frequency peaks in six Kepler stars with stochastically excited pulsations

    Jiménez, A.; García, R. A.; Pérez Hernández, F.; Mathur, S.

    2015-11-01

    Gravito-acoustic modes in the Sun and other stars propagate in resonant cavities with a frequency below a given limit known as the cut-off frequency. At higher frequencies, waves are no longer trapped in the stellar interior and become traveller waves. In this article, we study six pulsating solar-like stars at different evolutionary stages observed by the NASA Kepler mission. These high signal-to-noise targets show a peak structure that extends at very high frequencies and are good candidates for studying the transition region between the modes and interference peaks or pseudo-modes. Following the same methodology successfully applied on Sun-as-a-star measurements, we uncover the existence of pseudo-modes in these stars with one or two dominant interference patterns depending on the evolutionary stage of the star. We also infer their cut-off frequency as the midpoint between the last eigenmode and the first peak of the interference patterns. Using ray theory we show that, while the period of one of the interference patterns is very close to half the large separation, the period of the other interference pattern depends on the time phase of mixed waves, thus carrying additional information on the stellar structure and evolution. Appendix A is available in electronic form at http://www.aanda.org

  4. D-dimer and portal vein status in splenectomized Egyptian β-thalassemia major patients: a prospective single-thalassemia center experience.

    Elalfy, Mohsen Saleh; Andrawes, Nevine Gamal; Sadek, Azza Mohamad; Hussein, Omar; Abdou, Abeer

    2012-04-01

    Splenectomy is a recognized cause of portal vein thrombosis. Thirty-six β-thalassemia major (β-TM) patients were followed up for 36 months to evaluate changes in D-dimer levels (as a possible marker for thrombosis development) and portal vein status (by portal duplex ultrasound) at both early and late postlaparoscopic splenectomy periods. They were classified into group I if they were splenectomized in the study period (n = 12), or group II if they were splenectomized during the 5 years preceding the period (n = 24). In group I, D-dimer was measured 5 times: 1 day presplenectomy, the 1st week, 6th week, and 6th month postsplenectomy, and at the study end, whereas in group II, D-dimer was measured twice: at the study entry and end. Portal duplex was done 1 week postsplenectomy (group I) and at study end in both groups. Presplenectomy D-dimer levels in group I were significantly higher compared with the 6th month (P = .042) and study end (P = .03), whereas 1st week (postsplenectomy) D-dimer levels had a high mean of 3497.3 ng/mL, lowered at the 6th week (P = .017), at the 6th month (P = .008), and at study end (P = .005). D-dimer levels in group II showed no difference between study entry and end (P = .104). Portal vein "diameter and flow" were within normal findings in both groups. In this 3-year prospective study, a subclinical hypercoagulable state was detected 1 day prior to splenectomy and in the early postsplenectomy period, as evidenced by high D-dimer levels. Laparoscopic splenectomy was not associated with portal venous thrombosis either clinically or by duplex sonography. PMID:22475301

  5. Use of CT Angiography in a Country with Low Pulmonary Embolism Prevalence: Correlation with Clinical Pretest Probability and D-dimer Values

    Lee, Gee Won; Jeong, Yeon Joo; Kim, Chang Won [Dept. of Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institutute, Pusan (Korea, Republic of); Chun, Sung Won; Kim, Yeong Dae [Dept. of Cardiovascular and Thoracic Surgery, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institutute, Pusan (Korea, Republic of); Kim, Kun Il [Dept. of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine and Medical Research Institutute, Yangsan (Korea, Republic of); Song, Jong Woon [Dept. of Radiology, Haeundae Paik Hospital, Inje University School of Medicine, Pusan (Korea, Republic of)

    2011-05-15

    To assess the use of CT angiography (CTA) in the diagnostic evaluation of pulmonary thromboembolism (PE) in a country with low PE prevalence and correlate the diagnostic performance of CTA with the clinical pretest probability and D-dimer values. The institutional review board approved this retrospective study. The observers reviewed all 660 CTAs and calculated the PE clot burden scores. The pretest probability of PE according to the Wells criteria and D-dimer values were calculated (clinical data were available for 371 of the 660 patients). We correlated the PE positivity rates of CTA and a PE clot burden score with the D-dimer values and pretest probability using Pearson's correlation coefficient. Of the 371 patients whose clinical data were available, 122 (32.8%) had PEs. None of the patients with both a normal D-dimer value and a low clinical probability had a PE. PE positivity rates of CTA were correlated with clinical pretest probability (r = 0.164, p = 0.002) and D-dimer values (r = 0.361, p < 0.001). PE clot burden scores were correlated with D-dimer values (r = 0.296, p < 0.001). Although PE positivity rates of CTA in a country with low prevalence were higher than those in a country with a higher prevalence, approximately 30% of the yield still represents an overuse of CTA. CTA should be performed after the pretest probability has been assigned and if the result of a D-dimer assay is abnormal.

  6. Risk of recurrence in patients with pulmonary embolism: predictive role of D-dimer and of residual perfusion defects on lung scintigraphy.

    Poli, Daniela; Cenci, Caterina; Antonucci, Emilia; Grifoni, Elisa; Arcangeli, Chiara; Prisco, Domenico; Abbate, Rosanna; Miniati, Massimo

    2013-02-01

    The stratification of recurrence risk after a first episode of venous thromboembolism (VTE) is an important topic of research, especially in patients with pulmonary embolism (PE). Elevated D-dimer levels and residual vein obstruction (RVO) at compression ultrasonography have been studied as predictors of recurrence after withdrawing oral anticoagulant treatment (OAT). It is still unknown if residual perfusion defects (PD) on lung scintigraphy are related to recurrent PE. In the present study, we evaluated the association of PD with PE recurrence. The relationship between PD, elevated D-dimer levels, and RVO was also investigated. We prospectively followed 236 consecutive patients who survived a first episode of objectively confirmed PE, with or without deep-vein thrombosis. After at least three months of OAT, treatment was withdrawn in 139 patients. D-dimer levels were evaluated at one month of OAT withdrawal, RVO was measured, and perfusion lung scan (P-scan) was performed to evaluate PD. During follow-up, 20 patients experienced a recurrent episode of VTE. Elevated D-dimer levels were significantly associated with VTE recurrence, (p=0.003). RVO was present in 22% of the patients with recurrence and in 7.5% of those without (p=0.07). No significant association was found between PD >10% and VTE recurrence, D-dimer, or RVO. In conclusion, we confirmed the positive predictive value of elevated D-dimer levels for recurrent VTE. Residual PD on lung scintigraphy are neither predictive of recurrence nor related to D-dimer levels or RVO. PMID:23196319

  7. [Quantification of D-dimer and soluble fibrin in blood plasma of people with ischemic heart disease and hypertension].

    Lugovskoĭ, E V; Kolesnikova, I N; Lugovskaia, N E; Litvinova, L M; Gritsenko, P G; Gogolinskaia, G K; Liashko, E D; Kostiuchenko, E P; Remizovskiĭ, G A; Pedchenko, V N; Komisarenko, S V

    2004-01-01

    The method of D-dimer quantification in the human blood plasma has been developed using monoclonal antibodies 111-3b and II-4d. The method has been verified on the blood plasma of the patients with ischemic heart disease with and without stenocardia and with hypertension. The results showed that at ischemic heart disease with and without stenocardia and at hypertension the quantities of D-dimer in the blood plasma were generally less than the highest normal level 500 ng/ml (64.3%, 76.2% and 95%, correspondingly). The semiquantitative measurements of soluble fibrin levels in blood plasmas of the patients with ischemic heart disease and hypertension have been performed. It has been shown that the quantity of soluble fibrin at these diseases range greatly from PAAG with SDS showed that the soluble fibrin at these diseases had the mo- lecular mass of the fibrin (ogen). Thus the soluble fibrin in blood plasmas analysed consisted mainly of fibrin desAA oligomers (may be with fibrinogen incorporation) which are not stabilized by the factor XIIIa. PMID:16350758

  8. Bivariate distributions in statistical spectroscopy studies: Fixed-J level densities, fixed-J averages and spin cut-off factors

    Analytical studies with the TBRE ensemble, supplemented by numerical calcultions with realistic interactions show that for large particle numbers, the bivariate cumulants (ksub(rs)) defined for the Hamiltonian operator (H) and the Jsub(z) operator, are very small; vertical strokeksub(rs)vertical stroke< or approx.0.3 for 3<=r+s<=6. As a result the expansions around a bivariate normal density are meaningful for the fixed-M densities (rho(E,M)). We adopt a bivariate Edgeworth expansion for rho(E,M) and give a compact form for the same. Finally using this rho(E,M) (which also define fixed-J densities uniquely), new series expansions are given for fixed-M (and hence for fixed-J) averages of the powers of H and also for the spin cut-off factors. (orig.)

  9. Application of High-Density Seismic Image in Nondestructive Exploration of Cut-off Cement-Soil Wall in Earth Dam

    CAI Jing; WANG Jianhua; ZHANG Xianmin

    2005-01-01

    In order to quickly explore the quality of cut-off wall in dams, a new method of high-density seismic image was adopted and estimated by model and in-situ wall tests.The vibration exciter was employed and several parameters such as hypocentral distance, length of signal record and sampling space in signal collection were determined, which are 8 m, 0.25 ms and 128 ms respectively. Through time and frequency field signal analyses, it is concluded that, the smaller arrival times of reflected longitudinal and surface waves, and the higher their main frequencies, the higher the strength of the wall, vice versa. Accordingly the construction quality of the wall can be evaluated quickly by high-density seismic image.

  10. Diagnostic Accuracy of Sixty Four Multi-Slice CT Angiography in Assessment of Arterial Cut-Off and Run-Off in Comparison with Surgical Findings

    M. Noaparast

    2011-06-01

    Full Text Available Background/Objective: The accurate anatomic mapping and determination of the severity of arterial disease, an important health problem of the elderly, is of great significance. We aimed todetermine the diagnostic value of 64-multislice CT angiography (MSCTA in run-off and cut-off sites of arterial disease.Patients and Methods: Throughout the study, MSCTA followed by an operative intervention was carried out on a total of 38 patients with clinical signs and symptoms suggestive of arterialdisease (AD all of whom had the indication for vascular surgery. The mean age of patients was 34±15.86 (range, 23 to 93 years. MSCTA was executed using a 64-slice CT scanner, during the arterial phase of injecting the nonionic, contrast medium with a power injector at the rate of 5 ml/sec into the antecubital vein and exploration and revascularization of peripheral arterial disease was performed intraoperatively.Results: Atherosclerosis and arterial disease, the most common causes of vascular occlusion,were more common in the lower extremities. According to MSCTA findings, the most frequentsite of stenosis was the superficial femoral artery. Spearman’s correlation coefficient showed a high degree of agreement amongst the raters. The sensitivity, specificity, positive predictivevalue (PPV, negative predictive value (NPV and the accuracy of MSCTA compared to surgery were 83.8%, 96%, 96.8%, 81.3% and 89%, respectively. MSCTA findings were compared with surgeryas a standard of reference, which showed concordance in the majority of cases (81.6%. Cut-off sites were correctly identified by MSCTA in 97.3% of the patients and the most common sites of discordance were the run-off sites (18.2%.Conclusion: MSCTA angiography as a novel diagnostic modality may be a suitable alternative and a viable choice for routine clinical diagnosis.

  11. EARLY APPLICATION OF HIGH CUT-OFF HAEMODYALISIS FOR DE-NOVO MYELOMA NEPHROPATHY IS ASSOCIATED WITH LONG-TERM DIALYSIS-INDEPENDENCY AND RENAL RECOVERY

    Alhossain A. Khalafallah

    2013-01-01

    Full Text Available Background Multiple myeloma (MM is a haematological malignancy associated with kidney injury resulting from cast nephropathy, which can be caused by monoclonal free light chains (FLC. It has been demonstrated that reduction of FLC can lead to a higher proportion of patients recovering renal function with a better outcome, especially if extended high cut-off haemodialysis (HCO-HD combined with chemotherapy is used. Patients and Methods In this study, four cases of MM nephropathy were treated with HCO-HD and chemotherapy at a single institution during the period from August 2009 to August 2011. All of the patients presented with acute renal failure and high serum FLC. All patients underwent a bone marrow biopsy to confirm the diagnosis of MM, according to the WHO criteria. Three patients had de-novo MM and one patient had relapsed light chain myeloma disease. All patients underwent HCO-HD concomitantly with specific myeloma therapy once the diagnosis or relapse of MM was established. Results After a median follow up of 26 months, (range, 13-36 our data showed that all patients had a significant decrease in serum FLC through HCO-HD, proving the effectiveness of HCO-HD in managing MM. De-novo MM patients restored their renal function and achieved low-level FLC early on the treatment and become dialysis-independent. One patient with relapsed myeloma remained dialysis dependant. Conclusion Our study suggests that if myeloma nephropathy associated with light-chain disease, HCO-HD should be initiated as early as possible. At the same time a specific MM treatment should be initiated to gain control of the disease and salvage the kidneys in order to achieve dialysis-independency. Further trials to confirm our results are warranted. Key Words: Multiple myeloma, renal failure, High cut-off haemodialysis, chemotherapy, outcome.

  12. Diagnostic accuracy of sixty four multi-slice CT angiography in assessment of arterial cut-off and run-off in comparison with surgical findings

    The accurate anatomic mapping and determination of the severity of arterial disease, an important health problem of the elderly, is of great significance. We aimed to determine the diagnostic value of 64-multislice CT angiography in run-off and cut-off sites of arterial disease. Patients and Methods: Throughout the study, multislice CT angiography followed by an operative intervention was carried out on a total of 38 patients with clinical signs and symptoms suggestive of arterial disease all of whom had the indication for vascular surgery. The mean age of patients was 34±15.86 (range, 23 to 93) years. Multislice CT angiography was executed using a 64-slice CT scanner, during the arterial phase of injecting the nonionic, contrast medium with a power injector at the rate of 5 ml/sec into the antecubital vein and exploration and revascularization of peripheral arterial disease was performed intraoperatively. Results: Atherosclerosis and arterial disease, the most common causes of vascular occlusion, were more common in the lower extremities. According to multislice CT angiography findings, the most frequent site of stenosis was the superficial femoral artery. Spear man's correlation coefficient showed a high degree of agreement amongst the raters. The sensitivity, specificity, positive predictive value, negative predictive value and the accuracy of multislice CT angiography compared to surgery were 83.8%, 96%, 96.8%, 81.3% and 89%, respectively. Multislice CT angiography findings were compared with surgery as a standard of reference, which showed concordance in the majority of cases (81.6%). Cut-off sites were correctly identified by multislice CT angiography in 97.3% of the patients and the most common sites of discordance were the run-off sites (18.2%). Conclusion: multislice CT angiography angiography as a novel diagnostic modality may be a suitable alternative and a viable choice for routine clinical diagnosis.

  13. Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR) for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007)

    Rashidi Armin; Nakhjavani Manouchehr; Zandieh Ali; Khalilzadeh Omid; Ashraf Haleh; Esteghamati Alireza; Haghazali Mehrdad; Asgari Fereshteh

    2010-01-01

    Abstract Aim We have recently determined the optimal cut-off of the homeostatic model assessment of insulin resistance for the diagnosis of insulin resistance (IR) and metabolic syndrome (MetS) in non-diabetic residents of Tehran, the capital of Iran. The aim of the present study is to establish the optimal cut-off at the national level in the Iranian population with and without diabetes. Methods Data of the third National Surveillance of Risk Factors of Non-Communicable Diseases, available f...

  14. The Combination of D-Dimer and Peritoneal Irritation Signs as a Potential Indicator to Exclude the Diagnosis of Intestinal Necrosis.

    Yang, Kun; Wang, Wei; Zhang, Wei-Han; Chen, Xiao-Long; Zhou, Jing; Chen, Xin-Zu; Zhang, Bo; Chen, Zhi-Xin; Zhou, Zong-Guang; Hu, Jian-Kun

    2015-10-01

    Intestinal necrosis is a life-threatening disease, and its prompt and accurate diagnosis is very important. This study aimed to evaluate the value of D-dimer as a marker for early diagnosis of bowel necrosis. From 2009 to 2013, patients undergoing operation due to acute intestinal obstruction were retrospectively analyzed. Clinicopathologic characteristics were compared among no ischemia group, reversible ischemia group, and bowel necrosis group. There were totally 274 patients being included for analyses. Patients with bowel necrosis had a significant highest level of D-dimer compared with other 2 groups (P =  .007) when FEU unit was applied. The optimal cutoff value of D-dimer levels as an indicator in diagnosing bowel necrosis was projected to be 1.965 mg/L, which yielded a sensitivity of 84.0%, a specificity of 45.6%, a positive predictive value of 60.7%, and a negative predictive value of 74.0%. And the sensitivity of 84.0% and specificity of 70.0% were detected, when 1.65 mg/L of D-dimer was set as the cutoff value to distinguish the reversible ischemia and bowel necrosis. The corresponding results in patients with no or slight peritoneal irritation signs were 85.2%, 44.7%, 35.4% and 89.5% respectively. The sensitivity and negative predictive value were 96.0% and 91.7%, respectively, when D-dimer and peritoneal irritation signs were combined to perform the parallel analysis. The combination of D-dimer and peritoneal irritation signs could generate a reliable negative predictive value, which is helpful to exclude the diagnosis of intestinal necrosis. However, it should also be proved in well-designed large-scale prospective study. PMID:26448003

  15. Dynamic evolution of D-dimer level in cerebrospinal fluid predicts poor outcome in patients with spontaneous intracerebral hemorrhage combined with intraventricular hemorrhage.

    Chen, Chih-Wei; Wu, En-Hsuan; Huang, Judy; Chang, Wen-Tsan; Ao, Kam-Hou; Cheng, Tain-Junn; Yang, Wuyang

    2016-07-01

    The risk of mortality in patients with intracerebral hemorrhage (ICH) significantly increases when complicated by intraventricular hemorrhage (IVH). We hypothesize that serial measurement of cerebrospinal fluid (CSF) D-dimer levels in patients with both ICH and IVH may serve as an early marker of IVH severity. We performed a prospective study of 43 consecutive ICH patients combined with IVH and external ventricular drainage placement admitted in our institution from 2005-2006. IVH severity (Graeb score) and fibrinolytic activity were evaluated continuously for 7days using CT scans and CSF D-dimer levels. The primary outcome was 30day mortality. Overall 30day mortality was 26% (n=11), with eight deaths (72.7%) after 3days (D3). Graeb score and CSF D-dimer on admission (D0) were not significantly different between survivors and non-survivors. The temporal profiles of both parameters were distinctly different, with a downward trend in survivors and an upward trend in non-survivors. A mortality rate of 54% was observed between D0-D3 when both scores increased during this interval. In contrast, the mortality was only 4% when both measures decreased during this interval. Early phase (D0-D3) CSF D-dimer or Graeb score change demonstrated high sensitivity of 88% and specificity of 81% when predicting 30day mortality. Early phase CSF D-dimer change in patients with both ICH and IVH is accurate in predicting mortality and may be utilized as a cost-effective surrogate indicator of IVH severity. Serial monitoring of CSF D-dimer dynamic changes is useful for early identification of patients with hematoma progression and poor outcome. PMID:27050917

  16. The Value of D-Dimer in Diagnosis of Acute Mesenteric Ischemia and Differential Diagnosis from Acute Pancreatitis and Acute Cholecystitis

    Semih Hot; Nüvit Duraker; Ayhan Sarı; Kenan Çetin

    2016-01-01

    Objective: Because of its poor prognosis and high mor­tality rate, early diagnosis of acute mesenteric ischemia (AMI) is a challenge. The value of serum markers in the diagnosis of AMI is limited and the studies related with the D-dimer test carried out in recent years. In this prospec­tive study we investigated the value of the level of plasma D-dimer in the diagnosis of AMI and the differential diag­nosis from acute pancreatitis and acute cholecystitis. Methods: We included 89 patients w...

  17. Simultaneous determination of CRP and D-dimer in human blood plasma samples with White Light Reflectance Spectroscopy.

    Koukouvinos, Georgios; Petrou, Panagiota; Misiakos, Konstantinos; Drygiannakis, Dimitris; Raptis, Ioannis; Stefanitsis, Gerasimos; Martini, Spyridoula; Nikita, Dimitra; Goustouridis, Dimitrios; Moser, Isabella; Jobst, Gerhard; Kakabakos, Sotirios

    2016-10-15

    A dual-analyte assay for the simultaneous determination of C-reactive protein (CRP) and D-dimer in human blood plasma based on a white light interference spectroscopy sensing platform is presented. Measurement is accomplished in real-time by scanning the sensing surface, on which distinct antibody areas have been created, with a reflection probe used both for illumination of the surface and collection of the reflected interference spectrum. The composition of the transducer, the sensing surface chemical activation and biofunctionalization procedures were optimized with respect to signal magnitude and repeatability. The assay format involved direct detection of CRP whereas for D-dimer a two-site immunoassay employing a biotinylated reporter antibody and reaction with streptavidin was selected. The assays were sensitive with detection limits of 25ng/mL for both analytes, precise with intra- and inter-assay CV values ranging from 3.6% to 7.7%, and from 4.8% to 9.5%, respectively, for both assays, and accurate with recovery values ranging from 88.5% to 108% for both analytes. Moreover, the values determined for the two analytes in 35 human plasma samples were in excellent agreement with those received for the same samples by standard diagnostic laboratory instrumentation employing commercial kits. The excellent agreement of the results supported the validity of the proposed system for clinical application for the detection of multiple analytes since it was demonstrated that up to seven antibody areas can be created on the sensing surface and successfully interrogated with the developed optical set-up. PMID:26675113

  18. Direct Extraction of InP/GaAsSb/InP DHBT Equivalent-Circuit Elements From S-Parameters Measured at Cut-Off and Normal Bias Conditions

    Johansen, Tom Keinicke; Leblanc, Rémy; Poulain, Julien;

    2016-01-01

    A unique direct parameter extraction method for the small-signal equivalent-circuit model of InP/GaAsSb/InP double heterojunction bipolar transistors (DHBTs) is presented. $S$-parameters measured at cut-off bias are used, at first, to extract the distribution factor $X_{0}$ for the base...

  19. Prevalence of swallowing and speech problems in daily life after chemoradiation for head and neck cancer based on cut-off scores of the patient-reported outcome measures SWAL-QOL and SHI

    Rinkel, Rico N; Verdonck-de Leeuw, Irma M; Doornaert, Patricia; Buter, Jan; de Bree, Remco; Langendijk, Johannes A; Aaronson, Neil K; Leemans, C René

    2015-01-01

    The objective of this study is to assess swallowing and speech outcome after chemoradiation therapy for head and neck cancer, based on the patient-reported outcome measures Swallowing Quality of Life Questionnaire (SWAL-QOL) and Speech Handicap Index (SHI), both provided with cut-off scores. This is

  20. Prevalence of swallowing and speech problems in daily life after chemoradiation for head and neck cancer based on cut-off scores of the patient-reported outcome measures SWAL-QOL and SHI

    Rinkel, Rico N.; Verdonck-de Leeuw, Irma M.; Doornaert, Patricia; Buter, Jan; de Bree, Remco; Langendijk, Johannes A.; Aaronson, Neil K.; Leemans, C. Rene

    2016-01-01

    The objective of this study is to assess swallowing and speech outcome after chemoradiation therapy for head and neck cancer, based on the patient-reported outcome measures Swallowing Quality of Life Questionnaire (SWAL-QOL) and Speech Handicap Index (SHI), both provided with cut-off scores. This is

  1. Removal of methadone by extended dialysis using a high cut-off dialyzer: implications for the treatment of overdose and for pain management in patients undergoing light chain removal.

    Arelin, Viktor; Schmidt, Julius J; Kayser, Nathalie; Kühn-Velten, W Nikolaus; Suhling, Hendrik; Eden, Gabriele; Kielstein, Jan T

    2016-06-01

    The synthetic opioid methadone hydrochloride has a low molecular weight of 346 D, a high volume of distribution (4 - 7 L/kg), and is lipophilic. It is used as an analgesic and for the maintenance treatment of opiate dependence. In drug addicts, methadone is frequently involved in mixed intoxications that can lead to death. Here we present the case of a drug addict in whom a high cut-off dialysis membrane together with extended dialysis was used in the setting of suspected overdose and acute kidney injury. Although the observed dialyzer plasma clearance (31.5 mL/min) and reduction ratio (38%) were higher than previously reported for standard hemodialysis, the total amount of methadone in the spent dialysate after 1 extended dialysis session was quite low. Hence, even extended dialysis with a high cut-off membrane does not seem to offer a clinically relevant benefit in the setting of overdose for enhanced methadone removal. On the other hand, in patients undergoing high cut-off dialysis for the removal of light chains, methadone could still be used as an analgesic without an additional dose after high cut-off hemodialysis. PMID:27116939

  2. Optimal cut-off of homeostasis model assessment of insulin resistance (HOMA-IR for the diagnosis of metabolic syndrome: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007

    Rashidi Armin

    2010-04-01

    Full Text Available Abstract Aim We have recently determined the optimal cut-off of the homeostatic model assessment of insulin resistance for the diagnosis of insulin resistance (IR and metabolic syndrome (MetS in non-diabetic residents of Tehran, the capital of Iran. The aim of the present study is to establish the optimal cut-off at the national level in the Iranian population with and without diabetes. Methods Data of the third National Surveillance of Risk Factors of Non-Communicable Diseases, available for 3,071 adult Iranian individuals aging 25-64 years were analyzed. MetS was defined according to the Adult Treatment Panel III (ATPIII and International Diabetes Federation (IDF criteria. HOMA-IR cut-offs from the 50th to the 95th percentile were calculated and sensitivity, specificity, and positive likelihood ratio for MetS diagnosis were determined. The receiver operating characteristic (ROC curves of HOMA-IR for MetS diagnosis were depicted, and the optimal cut-offs were determined by two different methods: Youden index, and the shortest distance from the top left corner of the curve. Results The area under the curve (AUC (95%CI was 0.650 (0.631-0.670 for IDF-defined MetS and 0.683 (0.664-0.703 with the ATPIII definition. The optimal HOMA-IR cut-off for the diagnosis of IDF- and ATPIII-defined MetS in non-diabetic individuals was 1.775 (sensitivity: 57.3%, specificity: 65.3%, with ATPIII; sensitivity: 55.9%, specificity: 64.7%, with IDF. The optimal cut-offs in diabetic individuals were 3.875 (sensitivity: 49.7%, specificity: 69.6% and 4.325 (sensitivity: 45.4%, specificity: 69.0% for ATPIII- and IDF-defined MetS, respectively. Conclusion We determined the optimal HOMA-IR cut-off points for the diagnosis of MetS in the Iranian population with and without diabetes.

  3. Logarithmic Entropy-Corrected Holographic Dark Energy in Hořava-Lifshitz cosmology with Granda-Oliveros cut-off

    Pasqua, Antonio; Chattopadhyay, Surajit

    2013-12-01

    In this work, we studied the Logarithmic Entropy-Corrected Holographic Dark Energy (LECHDE) model in a spatially non-flat universe and in the framework of Hořava-Lifshitz cosmology. As infrared cutoff of the system we considered the cut-off recently proposed by Granda and Oliveros which contains two terms, one proportional to H 2 and one to . For the two cases containing non-interacting and interacting Dark Energy (DE) and Dark Matter (DM), we obtained the exact differential equation that determines the evolution of the density parameter. Moreover, we derived the expressions of the deceleration parameter q and, using a parametrization of the equation of state (EoS) parameter ω D of our model as ω D ( z)= ω 0+ ω 1 z, we derived both the expressions of ω 0 and ω 1 for both non-interacting and interacting cases. All derivations made in this work are done in small redshift approximation and for low redshift expansion of the equation of state (EoS) parameter.

  4. UV Filtering of Dye-Sensitized Solar Cells: The Effects of Varying the UV Cut-Off upon Cell Performance and Incident Photon-to-Electron Conversion Efficiency

    Matthew Carnie

    2012-01-01

    Full Text Available With current technology, UV filters are essential to ensure long-term dye-sensitized solar cell (DSC stability. Blocking photons, however, will have an obvious effect on device performance and upon its incident photon-to-current conversion efficiency (IPCE. Filters have been applied to DSC devices with a range of cut-off wavelengths in order to assess how different levels of filtering affect the performance and IPCE of devices made with three different dyes, namely N719, Z907, and N749. It is shown that dyes that extend their IPCE further into the NIR region suffer lesser relative efficiency losses due to UV filtering than dyes with narrower action spectra. Furthermore, the results are encouraging to those working towards the industrialisation of DSC technology. From the results presented it can be estimated that filtering at a level intended to prevent direct band gap excitation of the TiO2 semiconductor should cause a relative drop in cell efficiency of no more than 10% in forward illuminated devices and no more than 2% in reverse illuminated devices.

  5. Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms.

    Ian Morrissey

    Full Text Available To date there are no clear criteria to determine whether a microbe is susceptible to biocides or not. As a starting point for distinguishing between wild-type and resistant organisms, we set out to determine the minimal inhibitory concentration (MIC and minimal bactericidal concentration (MBC distributions for four common biocides; triclosan, benzalkonium chloride, chlorhexidine and sodium hypochlorite for 3319 clinical isolates, with a particular focus on Staphylococcus aureus (N = 1635 and Salmonella spp. (N = 901 but also including Escherichia coli (N = 368, Candida albicans (N = 200, Klebsiella pneumoniae (N = 60, Enterobacter spp. (N = 54, Enterococcus faecium (N = 53, and Enterococcus faecalis (N = 56. From these data epidemiological cut-off values (ECOFFs are proposed. As would be expected, MBCs were higher than MICs for all biocides. In most cases both values followed a normal distribution. Bimodal distributions, indicating the existence of biocide resistant subpopulations were observed for Enterobacter chlorhexidine susceptibility (both MICs and MBCs and the susceptibility to triclosan of Enterobacter (MBC, E. coli (MBC and MIC and S. aureus (MBC and MIC. There is a concern on the potential selection of antibiotic resistance by biocides. Our results indicate however that resistance to biocides and, hence any potential association with antibiotic resistance, is uncommon in natural populations of clinically relevant microorganisms.

  6. Water cut-off construction for bulkhead of very deep waste treatment plant using premixed cohesive soil. Premix nenseido ni yoru daisuishin haikibutsu shorijo gogan no shisuiko

    Iida, I. (Toa Corp., Tokyo (Japan))

    1994-03-25

    Recently waste treatment plants have been developed in the suburban coastal area or off shore, requiring controlled-type revetment or reclamation for the circumferential sea area. This report describes the outline of premix water cutoff construction having been applied to the center-partitioned revetment in the reclaiming construction work in Minami-Honmoku Pier Area, Yokohama. The premix water cut-off method is a construction method where packed sediment is mixed with a small amount of cement and a separation-preventive agent and then is thrown to develop ground. This time, to effectively re-use dredged soil and cohesive soil, these soils were mixed with a caking agent and placed onto the sea floor. The total length of construction was ca. 450m; the maximum water depth was 30m; and the placed amount was 79705m[sup 3]. Four 50m[sup 3]/h-class mud treating machines were mounted on two ships, to which a slurry plant ship and a mud treating plant were joined to make-up a fleet. The forced pump feed method was adopted for placing and construction was completed with a control system perfect in workmanship and quality. 15 figs., 6 tabs.

  7. Near-elliptic core triangular-lattice and square-lattice PCFs: a comparison of birefringence, cut-off and GVD characteristics towards fiber device application

    Maji, Partha Sona

    2014-01-01

    In this work, detailed numerical analysis of the near-elliptic core index-guiding triangular-lattice and square-lattice photonic crystal fiber (PCFs) are reported for birefringence, single mode, cut-off behavior, group velocity dispersion and effective area properties. For the same relative values of d/P, triangular-lattice PCFs show higher birefringence whereas the square-lattice PCFs show a wider range of single-mode operation. Square-lattice PCF was found to be endlessly single-mode for higher air-filling fraction (d/P). Smaller lengths of triangular-lattice PCF are required for dispersion compensation whereas PCFs with square-lattice with nearer relative dispersion slope (RDS) can better compensate the broadband dispersion. Square-lattice PCFs show ZDW red-shifted, making it preferable for mid-IR supercontinuum generation (SCG) with highly non-linear chalcogenide material. Square-lattice PCFs show higher dispersion slope that leads to compression of the broadband, thus accumulating more power in the pulse...

  8. The relationship of D-dimer levels with risk for developing deep-vein thrombosis and/or pulmonary thromboembolism after orthopaedic trauma surgery

    Deep venous thrombosis (DVT) and pulmonary embolism (PE) are common complications in trauma patients. Fibrin-related markers (FRMs), such as fibrin and fibrinogen degradation products (FDPs), D-dimer, and soluble fibrin (SF), are considered to be useful for the diagnosis of thrombosis (DVT). We report on 3-month follow-up of fibrinolytic activity after Orthopaedic Trauma Surgery (OTS). Patients who entered the study were divided into (group 1) patients who did not develop DVT/PE after OTS while patients who developed DVT/PE were included in (group 2). Blood samples were obtained on day of surgery and postoperative days 1, 7 and 30, and assayed for blood counts, C-reactive protein (CRP), and Ddimers. Demographic and clinical data were also collected. Postoperative levels of Ddimers of both groups increased on day 1, and remained elevated on day 30. Postoperative levels of D-dimers on day 1, 7 and 30 were higher in group 2 (p<0.05). There were no differences in perioperative levels of CRP between groups, and they correlated with D-dimers both preoperatively and on day 30. Taken together, these data suggest that orthopaedic trauma surgery induced an activation of coagulation and fibrinolysis. This situation lasts at least as late as 30 days after surgery. The D-dimer levels were significantly higher in patients developing DVT/PE post OTS. (author)

  9. The predictive values of D-dimer for the early prognosis of the acute myocardial infarction(AMI):a review of 3134 AMI patients

    杨军

    2013-01-01

    Objective To investigate whether D-dimer could be an early warning signal for patients with acute myocardial infarction(AMI),then may be helpful in risk accessment in emergency department. Methods Three thousand one hundred and thirty-four emergency AMI cases admitted to

  10. High levels of D-dimer correlated with disease status and poor prognosis of inoperable metastatic colorectal cancer patients treated with bevacizumab

    Liming Zhu

    2014-01-01

    Conclusion: High levels of plasma baseline D-dimer correlated with high tumor load, advanced disease status and poor prognosis of inoperable mCRC patients treated with bevacizumab. However, clinical research on a much larger cohort of patients will be required to verify these findings.

  11. Shifting Up Cutoff Value of D-Dimer in the Evaluation of Pulmonary Embolism: A Viable Option? Possible Risks and Benefits

    Bennidor Raviv

    2012-01-01

    Full Text Available Objectives. To evaluate the viability of the possibility to use a higher D-dimer value than the one used today in the clinical algorithms evaluating patients suspected to have pulmonary embolism. Methods. A retrospective analysis of 300 serial patients for whom D-dimer values were taken during a 10 month period in the emergency room of a tertiary medical center. Results. Our analysis showed that it may be safe and cost effective to use a D-dimer value of 900 ng/ml rather than the value of 500 ng/ml accepted today, with sensitivity of 94.4%. In younger patients [under 40 years] the sensitivity reached was even higher—100%. Conclusions. Raising cutoff values of D-dimer in screening for pulmonary embolism seems a viable option. There may be a place for “tailoring” cutoff values according individual patient characteristics, such as according age groups. More studies of the subject are warranted.

  12. Comparing the Cervista HPV HR test and Hybrid Capture 2 assay in a Dutch screening population: improved specificity of the Cervista HPV HR test by changing the cut-off.

    Aniek Boers

    Full Text Available The diagnostic performance of the widely-used Cervista HPV HR test was compared to the Hybrid Capture 2 (HC2 test in a Dutch population-based cervical cancer screening program. In 900 scrapings of women with normal cytomorphology, specificity was 90% (95%CI: 87.84-91.87 for the Cervista HPV HR test and 96% (95%CI: 94.76-97.37 for the HC2 test with 93% agreement between both tests (κ = 0.5, p<0.001. The sensitivity for CIN2+ using 65 scrapings of women with histological-confirmed CIN2+ was 91% (95%CI: 80.97-96.51 for the Cervista HPV HR test and 92% (95%CI: 82.94-97.43 for the HC2 test with 95% agreement between both tests (κ = 0.7, p<0.001. Fifty-seven of 60 HC2 negative/Cervista positive cases tested HPV-negative with PCR-based HPV assays; of these cases 56% were defined as Cervista triple-positive with FOZ values in all 3 mixes higher than the second cut-off of 1.93 (as set by manufacturer. By setting this cut-off at 5.0, specificity improved significantly without affecting sensitivity. External validation of this new cut-off at 5.0 in triple-positive scrapings of women selected from the SHENCCASTII database revealed that 22/24 histological normal cases now tested HPV-negative in the Cervista HPV HR test, while CIN2+ lesions remained HPV-positive. The intra-laboratory reproducibility of the Cervista HPV HR test (n = 510 showed a concordance of 92% and 93% for cut-off 1.93 and 5.0 (κ = 0.83 and κ = 0.84, p<0.001 and inter-laboratory agreement of the Cervista HPV HR test was 90% and 93% for cut-off 1.93 and 5.0 (κ = 0.80 and κ = 0.85, p<0.001. In conclusion, the specificity of the Cervista HPV HR test could be improved significantly by increasing the second cut-off from 1.93 to 5.0, without affecting the sensitivity of the test in a population-based screening setting.

  13. Specific cut-off points for waist circumference and waist-to-height ratio as predictors of cardiometabolic risk in Black subjects: a cross-sectional study in Benin and Haiti

    EL Mabchour A

    2015-10-01

    Full Text Available Asma EL Mabchour,1 Hélène Delisle,1 Colette Vilgrain,2 Philippe Larco,2 Roger Sodjinou,3 Malek Batal1 1Transition Nutritionnelle (TRANSNUT, WHO Collaborating Centre on Nutrition Changes and Development, Department of Nutrition, Faculty of Medicine, University of Montreal, Montreal, QC, Canada; 2Haitian Foundation for Diabetes and Cardiovascular Diseases (FHADIMAC, Port-au-Prince, Haiti; 3West Africa Health Organization (WAHO, Bobo-Dioulasso, Burkina Faso Purpose: Waist circumference (WC and waist-to-height ratio (WHtR are widely used as indicators of abdominal adiposity and the cut-off values have been validated primarily in Caucasians. In this study we identified the WC and WHtR cut-off points that best predicted cardiometabolic risk (CMR in groups of African (Benin and African ancestry (Haiti Black subjects. Methods: This cross-sectional study included 452 apparently healthy subjects from Cotonou (Benin and Port-au-Prince (Haiti, 217 women and 235 men from 25 to 60 years. CMR biomarkers were the metabolic syndrome components. Additional CMR biomarkers were a high atherogenicity index (total serum cholesterol/high density lipoprotein cholesterol ≥4 in women and ≥5 in men; insulin resistance set at the 75th percentile of the calculated Homeostasis Model Assessment index (HOMA-IR; and inflammation defined as high-sensitivity C-reactive protein (hsCRP concentrations between 3 and 10 mg/L. WC and WHtR were tested as predictors of two out of the three most prevalent CMR biomarkers. Receiver operating characteristic (ROC curves, Youden's index, and likelihood ratios were used to assess the performance of specific WC and WHtR cut-offs. Results: High atherogenicity index (59.5%, high blood pressure (23.2%, and insulin resistance (25% by definition were the most prevalent CMR biomarkers in the study groups. WC and WHtR were equally valid as predictors of CMR. Optimal WC cut-offs were 80 cm and 94 cm in men and women, respectively, which is exactly

  14. Cut off from supplies - sulfate exhaustion and implications for methane emissions in a brackish rewetted peatland after separation from the coast

    Koebsch, Franziska; Liu, Bo; Schmiedinger, Iris; Spitzy, Alejandro; Köhler, Stefan; Koch, Marian; Jurasinski, Gerald; Gehre, Matthias; Sachs, Torsten; Böttcher, Michael

    2016-04-01

    Coastal ecosystems are at the interface between marine and freshwater and exhibit a special geochemistry. We investigate the S and C geochemistry of a coastal, degraded fen peatland. The site has been cut off from the Baltic Sea since 1995 and was rewetted with freshwater from the surrounding catchment in 2010. Despite of locally high pore water sulfate (SO42-) concentrations, the fen turned into a strong source for methane (CH4) with annual budgets up to 0.26±0.06 kg m-2 (Hahn et al. 2015). To reconcile this apparent contradiction we use concentration patterns and stable isotope signatures of water, SO42-, pyrite, dissolved carbon, and CH4 (δ2H, δ13C, δ18O, δ34S) along a transect with increasing distance to the Baltic coastline (300-1500 m). The current peatland geochemistry is characterized by a combination of relict signals reflecting former brackish water intrusion events and indicators of recent human activities such as internal eutrophication and increasing freshwater contribution. The shallow peat layer (depth mostly ≤ 55 cm) exhibited a pronounced vertical gradient with a freshwater-front lying on top of the brackish water layer. S geochemistry was decoupled from present brackish water distribution as marine SO42- was almost completely biotically reduced and converted to pyrite. The remaining pore water SO42- pool was remarkably 34S-enriched in relation to Baltic Sea SO42- (up to +86.4 and +21‰, respectively) and also δ34S-values of pyrite were comparatively high (+4.8‰), thereby demonstrating a distinct reservoir effect under closed-system conditions. However, one of the profiles situated 1150 m from the Baltic Sea coast line exhibited a contrasting S pattern with pronounced excess of isotopically lighter SO42- at depth (up to 32.8 mM and +22.7‰). We hypothesize, that local groundwater seeps might provide electron acceptors such as NO3- for the contemporary oxidation of pyrite. δ13C in DIC exhibited a pronounced vertical shift from -23.9

  15. Anti-mullerian hormone cut-off values for predicting poor ovarian response to exogenous ovarian stimulation in in-vitro fertilization

    Ruma Satwik

    2012-01-01

    Full Text Available Objectives: (a To establish the cut-off levels for anti-Mullerian hormone (AMH in a population of Indian women that would determine poor response. (b To determine which among the three ie.,: age, follicle stimulating hormone (FSH, or AMH, is the better determinant of ovarian reserve. Study Design: Prospective observational study. Setting: In vitro fertilization (IVF unit of a tertiary hospital. Materials and Methods: The inclusion criterion was all women who presented to the center for in-vitro fertilization/Intracytoplasmic sperm injection (IVF/ICSI. The exclusion criteria were age >45 years, major medical illnesses precluding IVF or pregnancy, FSH more than 20 IU/L, and failure to obtain consent. The interventions including baseline pelvic scan, day 2/3 FSH, luteinizing hormone (LH, estradiol estimations, and AMH measurement on any random day of cycle were done. Subjects underwent IVF according to long agonist or antagonist protocol regimen. Oocyte recovery was correlated with studied variables. The primary outcome measure was the number of oocytes aspirated (OCR. Three categories of ovarian response were defined: poor response, OCR ≤ 3; average response, OCR between 4 and 15; hyperresponse, OCR > 15. Results: Of the 198 patients enrolled, poor, average, and hyperresponse were observed in 23%, 63%, and 14% respectively. Correlation coefficient for AMH with ovarian response was r = 0.591. Area under the curve (AUCs for poor response for AMH, subject′s age, and FSH were 0.768, 0.624, and 0.635, respectively. The discriminatory level of AMH for prediction of absolute poor response was 2 pmoL/l, with 98% specificity and 20% sensitivity. Conclusions: AMH fares better than age and FSH in predicting the overall ovarian response and poor response, though it cannot be the absolute predictor of non-responder status. A level of 2 pmol/l is discriminatory for poor response.

  16. The impact of cut-off lows on ozone in the upper troposphere and lower stratosphere over Changchun from ozonesonde observations

    Song, Yushan; Lü, Daren; Li, Qian; Bian, Jianchun; Wu, Xue; Li, Dan

    2016-02-01

    In situ measurements of the vertical structure of ozone were made in Changchun (43.53°N, 125.13°E), China, by the Institute of Atmosphere Physics, in the summers of 2010-13. Analysis of the 89 validated ozone profiles shows the variation of ozone concentration in the upper troposphere and lower stratosphere (UTLS) caused by cut-off lows (COLs) over Changchun. During the COL events, an increase of the ozone concentration and a lower height of the tropopause are observed. Backward simulations with a trajectory model show that the ozone-rich airmass brought by the COL is from Siberia. A case study proves that stratosphere-troposphere exchange (STE) occurs in the COL. The ozone-rich air mass transported from the stratosphere to the troposphere first becomes unstable, then loses its high ozone concentration. This process usually happens during the decay stage of COLs. In order to understand the influence of COLs on the ozone in the UTLS, statistical analysis of the ozone profiles within COLs, and other profiles, are employed. The results indicate that the ozone concentrations of the in-COL profiles are significantly higher than those of the other profiles between ±4 km around the tropopause. The COLs induce an increase in UTLS column ozone by 32% on average. Meanwhile, the COLs depress the lapse-rate tropopause (LRT)/dynamical tropopause height by 1.4/1.7 km and cause the atmosphere above the tropopause to be less stable. The influence of COLs is durable because the increased ozone concentration lasts at least one day after the COL has passed over Changchun. Furthermore, the relative coefficient between LRT height and lower stratosphere (LS) column ozone is -0.62, which implies a positive correlation between COL strength and LS ozone concentration.

  17. Exploration of cut-off value of TSH during screening of congenital hypothyroidism in the newborns%新生儿先天性甲状腺功能减退症筛查中TSH切值的探讨

    陈肖肖; 秦玉峰; 曲一平; 毛华庆; 施玉华; 赵正言

    2008-01-01

    新生儿筛查中发现,TSH水平与先天性甲状腺功能减退症(CH)检出率呈直线正相关.当TSH切值点分别为9、10、15和20 mU/L时,CH阳性检测敏感度分别 99.77%、96.80%、81.25%和71.88%.TSH>9 mU/L是较好的切点.%Positive linear correlation was found between TSH level and detection rate of congenital hypothyroidism (CH). When measured with a cut-off point at 9, 10, 15 and 20 mU/L of TSH, the sensitivity of positive detection rate for CH was 99.77%, 96.80%, 81.25% and 71.88%, respectively. TSH > 9 mU/L seems to be a reasonable cut-off value.

  18. Glycolipid metabolic status of overweight/obese adolescents aged 9- to 15-year-old and the BMI-SDS/BMI cut-off value of predicting dyslipidemiain boys, Shanghai, China: a cross-sectional study

    Gong, Chun-dan; Wu, Qiao-ling; Chen, Zheng; Zhang, Dan; Zhao, Zheng-yan; Peng, Yong-mei

    2013-01-01

    Background The prevalence of adolescents’ obesity and overweight has dramatically elevated in China. Obese children were likely to insulin resistance and dyslipidemia, which are risk factors of cardiovascular diseases. However there was no cut-off point of anthropometric values to predict the risk factors in Chinese adolescents. The present study was to investigate glycolipid metabolism status of adolescents in Shanghai and to explore the correlations between body mass index standard deviatio...

  19. Modeling and simulation of dual three phase induction machine in fault condition (two phase cut off) and propose a new approach of R.F.O vector control approach for torque oscillation reducing in fault mode

    Milli Monfared, J.; Abbaszadeh, K.; Fallah, E. [Amirkabir Univ. of Technology, Tehran (Indonesia)

    2000-08-01

    From the energy conversion point of view, structure of all electrical machines can be simplified to an equivalent two-phase machine. At normal operation this equivalent machine has a balanced structure which is the base of vector control equations at this mode. Similarly at phase - cut off condition this equivalent model has an unbalanced structure, which can be used to obtain vector control equations at this faulty mode. In this paper at first a dual three-phase induction machine has been modeled while two phase of stator is cut off, then vector control equations has been obtained from d-q model of machine. On the basis of these equations a new 'rotor field oriented control' approach is presented which indicate How the conventional R.F.0 control can be adapted with fault condition. Finally a computer simulation has been presented to compare the operation of conventional R.F.0 control with improved R.F.0 control, while two phase of machine is cut off. Results show considerable improvement in drive performance especially in torque oscillating reduction. (orig.)

  20. Dual energy CT pulmonary blood volume assessment in acute pulmonary embolism - correlation with D-dimer level, right heart strain and clinical outcome

    Bauer, Ralf W.; Frellesen, Claudia; Schell, Boris; Lehnert, Thomas; Jacobi, Volkmar; Vogl, Thomas J.; Kerl, J.M. [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Frankfurt (Germany); Renker, Matthias [Clinic of the Goethe University, Department of Diagnostic and Interventional Radiology, Frankfurt (Germany); Medical University of South Carolina, Heart and Vascular Center, Ashley River Tower, Charleston, SC (United States); Ackermann, Hanns [Clinic of the Goethe University, Department of Biostatistics and Mathematical Modelling, Frankfurt (Germany); Schoepf, U.J. [Medical University of South Carolina, Heart and Vascular Center, Ashley River Tower, Charleston, SC (United States)

    2011-09-15

    To investigate the role of perfusion defect (PD) size on dual energy CT pulmonary blood volume assessment as predictor of right heart strain and patient outcome and its correlation with d-dimer levels in acute pulmonary embolism (PE). 53 patients with acute PE who underwent DECT pulmonary angiography were retrospectively analyzed. Pulmonary PD size caused by PE was measured on DE iodine maps and quantified absolutely (VolPD) and relatively to the total lung volume (RelPD). Signs of right heart strain (RHS) on CT were determined. Information on d-dimer levels and readmission for recurrent onset of PE and death was collected. D-dimer level was mildly (r = 0.43-0.47) correlated with PD size. Patients with RHS had significantly higher VolPD (215 vs. 73 ml) and RelPD (9.9 vs. 2.9%) than patients without RHS (p < 0.003). There were 2 deaths and 1 readmission due of PE in 18 patients with >5% RelPD, while no such events were found for patients with <5% RelPD. Pulmonary blood volume on DECT in acute PE correlates with RHS and appears to be a predictor of patient outcome in this pilot study. (orig.)

  1. Determination of D-Dimers in condition of emergency: the D-Di Liatest. Threshold value in elimination of pulmonary emboli (PE)

    Several studies have shown that a low rate of D-Dimers (products of fibrin decay) measured by Elisa technique can eliminate the diagnosis of thrombo-embolic disease. However, the conventional Elisa technique is not adapted to emergency conditions. A new agglutination test of latex microparticles (D-Di Liatest) has been developed by Diagnostica Stago with a sensitivity of 100 ng/ml. Our goal was to determine the threshold of PE exclusion. Ninety six patients suspected of PE were included. The pulmonary perfusion scintigraphy (PPS), as a reference examination the positivity of which has been confirmed by clinical follow-up, has been carried out in association with the determination of plasmatic rates of D-Dimers by the techniques Elisa and Liatest based on different antibodies. A table is given containing the D-Di threshold rates obtained by these techniques. In conclusion, our results showed that the rate of D-Dimers which eliminate a PE is ≤ 500 ng/ml by Elisa and ≤ 400 ng/ml by Liatest with a VPN of 100%. However, the PPS remains necessary in 77% of cases. This work stresses the necessity of clinical validations for the new biological tests

  2. Preparation and Analysis of Lyophilization Characterization of Human D-dimer%人D-二聚体的制备及其冻干性质的分析

    武建伟; 才蕾; 王继华; 唐时幸

    2014-01-01

    以人源纤维蛋白原为原材料制备D-二聚体,将其制成冻干品并分析其冻干性质。使用凝血酶、Factor XIIIa酶解纤维蛋白原,获得交联纤维蛋白。经纤溶酶降解交联纤维蛋白,生成纤维蛋白降解产物。超滤除去纤维蛋白降解产物中的小分子物质,可获得较高纯度的D-二聚体。通过筛选和优化冻干方案,将D-二聚体制备成冻干品。经检测可知,D-二聚体冻干品可在37℃稳定保存12 d;复溶后在25℃稳定保存8 d;复溶后在4℃稳定保存30 d;复溶时,常用复溶溶剂对其复溶后的活性检测无明显影响。%D-dimer is formed by sequential action of 3 enzymes from fibrinogen. After producing D-dimer, we did the research on its lyophilization process. To produce cross-linked fibrin, fibrinogen was digested by thrombin and Factor XIIa. Then, fibrin degradation products (FDP)was prepared from cross-linked fibrin being degraded by plasmin. D-dimer was purified from FDP through ultrafiltration and prepared into lyophilized powder. By optimizing the lyophilization program, lyophilized D-dimer was stable for at least 12 days at 37℃, stable for at least 8 days at 25℃ and 30 days at 4℃ after reconstitution, and not different when being dissolved by different solvent.The preparation system established in this research is feasible and efficient. Depend on its stability, lyophilized D-dimer could be provided as biological raw materials for further research.

  3. Optimal cut-off point of BMI on age at menarche among Han nationality girls%汉族女生月经初潮年龄BMI最佳临界值研究

    张敏婕; 朱丁; 徐勇; 沈惠芬; 钱红丹

    2011-01-01

    Objective To analyze body mass index (BMI) and weight by using receiver operating curve(ROC) among girls of Han nationality, and to find the optimal cut-off point of BMI on age at menarche. Methods With the stratified cluster sampling, 10-14 years old Chinese girls were questionnaired. Both retrospective and prospective ways were used to investigate the age at menarche. Questionnaire also included the students' age at menarche, height and weight. Then the ROC was operated to analyze the areas under curve(ADC) and the sensitivity and specificity of optimal cut-off point of BMI and weight were calculated. Results The average age of menarche was 12.26, the AUC of BMI and weight were 0.68 and 0. 73. The optimal cut-off point of weight on different age groups were different, but the optimal cut-off point of BMI on age at menarche tended to be uniform. Conclusion The optimal cut-off point of BMI is applicable in predicting the age of menarche, and more verification should be carried out in the future when applying this optimal cut-off point.%目的 应用受试者工作特征ROC曲线分析BMI、体重曲线下面积,探讨女性月经初潮BMI的最佳临界值.方法 采用分层整群抽样方法,对无锡市10~14岁7 300名汉族女生进行问卷调杳,了解月经初潮年龄及身高、体重.绘制ROC曲线,观察曲线下面积,计算BMI、体重最佳临界值的灵敏度和特异度.结果 女生月经来潮率为40.45% (2 953/7 300),月经初潮平均年龄为12.26岁;不同年龄组已潮组和未潮组女生体重、BMI差异均有统计学意义(P值均<0.05).BMI、体重的ROC曲线下面积分别为0.68和0.73;不同年龄组女生体重有不同的最佳临界值,但不同年龄组BMI最佳临界值趋于一致.结论BMI最佳临界值对预测是否来潮有重要的应用价值,但其效果有待在实际应用中加以进一步验证.

  4. The Brazilian hazard-based cut-off criteria for pesticide registration: a critical appraisal / Critérios de exclusão baseados em perigo adotados no Brasil para registro de pesticidas: Uma avalição crítica

    Francisco José Roma Paumgartten

    2013-01-01

    Brazil, the world’s top consumer of agricultural pesticides, adopts a unique hazard-based cut-off approach to pesticide registration. Cut-off criteria for mutagenicity, carcinogenicity, teratogenicity, hormonal disturbances and damage to reproductive organs were introduced by the Pesticide Law enacted in 1989. As far as health is concerned, law enforcement is additionally regulated by rules issued by the federal health authority (National Agency for Health Surveillance – ANVISA). Contrasting ...

  5. 18F-FDG PET/CT for detection of malignant peripheral nerve sheath tumours in neurofibromatosis type 1: tumour-to-liver ratio is superior to an SUVmax cut-off

    To evaluate the usefulness of normalising intra-tumour tracer accumulation on 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) to reference tissue uptake for characterisation of peripheral nerve sheath tumours (PNSTs) in neurofibromatosis type 1 (NF1) compared with the established maximum standardised uptake value (SUVmax) cut-off of >3.5. Forty-nine patients underwent FDG PET/CT. Intra-tumour tracer uptake (SUVmax) was normalised to three different reference tissues (tumour-to-liver, tumour-to-muscle and tumour-to-fat ratios). Receiver operating characteristic (ROC) analyses were used out to assess the diagnostic performance. Histopathology and follow-up served as the reference standard. Intra-tumour tracer uptake correlated significantly with liver uptake (rs = 0.58, P = 0.016). On ROC analysis, the optimum threshold for tumour-to-liver ratio was >2.6 (AUC = 0.9735). Both the SUVmax cut-off value of >3.5 and a tumour-to-liver ratio >2.6 provided a sensitivity of 100 %, but specificity was significantly higher for the latter (90.3 % vs 79.8 %; P = 0.013). In patients with NF1, quantitative 18F-FDG PET imaging may identify malignant change in neurofibromas with high accuracy. Specificity could be significantly increased by using the tumour-to-liver ratio. The authors recommend further evaluation of a tumour-to-liver ratio cut-off value of >2.6 for diagnostic intervention planning. (orig.)

  6. {sup 18}F-FDG PET/CT for detection of malignant peripheral nerve sheath tumours in neurofibromatosis type 1: tumour-to-liver ratio is superior to an SUV{sub max} cut-off

    Salamon, Johannes [University Medical Centre Hamburg-Eppendorf, Department of Diagnostic and Interventional Radiology, Hamburg (Germany); University Hospital Hamburg-Eppendorf, Department of Diagnostic and Interventional Radiology, Hamburg (Germany); Veldhoen, Simon [University Medical Centre Hamburg-Eppendorf, Department of Diagnostic and Interventional Radiology, Hamburg (Germany); University Medical Centre Wuerzburg, Department of Diagnostic and Interventional Radiology, Wuerzburg (Germany); Apostolova, Ivayla [Otto-von-Guericke University, Department of Radiology and Nuclear Medicine, Magdeburg (Germany); Bannas, Peter; Yamamura, Jin; Herrmann, Jochen; Adam, Gerhard; Derlin, Thorsten [University Medical Centre Hamburg-Eppendorf, Department of Diagnostic and Interventional Radiology, Hamburg (Germany); Friedrich, Reinhard E. [University Medical Centre Hamburg-Eppendorf, Department of Oral and Maxillofacial Surgery, Hamburg (Germany); Mautner, Victor F. [University Medical Centre Hamburg-Eppendorf, Department of Neurology, Hamburg (Germany)

    2014-02-15

    To evaluate the usefulness of normalising intra-tumour tracer accumulation on {sup 18}F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) to reference tissue uptake for characterisation of peripheral nerve sheath tumours (PNSTs) in neurofibromatosis type 1 (NF1) compared with the established maximum standardised uptake value (SUVmax) cut-off of >3.5. Forty-nine patients underwent FDG PET/CT. Intra-tumour tracer uptake (SUVmax) was normalised to three different reference tissues (tumour-to-liver, tumour-to-muscle and tumour-to-fat ratios). Receiver operating characteristic (ROC) analyses were used out to assess the diagnostic performance. Histopathology and follow-up served as the reference standard. Intra-tumour tracer uptake correlated significantly with liver uptake (r{sub s} = 0.58, P = 0.016). On ROC analysis, the optimum threshold for tumour-to-liver ratio was >2.6 (AUC = 0.9735). Both the SUVmax cut-off value of >3.5 and a tumour-to-liver ratio >2.6 provided a sensitivity of 100 %, but specificity was significantly higher for the latter (90.3 % vs 79.8 %; P = 0.013). In patients with NF1, quantitative {sup 18}F-FDG PET imaging may identify malignant change in neurofibromas with high accuracy. Specificity could be significantly increased by using the tumour-to-liver ratio. The authors recommend further evaluation of a tumour-to-liver ratio cut-off value of >2.6 for diagnostic intervention planning. (orig.)

  7. Which are the cut-off values of 2D-Shear Wave Elastography (2D-SWE) liver stiffness measurements predicting different stages of liver fibrosis, considering Transient Elastography (TE) as the reference method?

    Sporea, Ioan, E-mail: isporea@umft.ro; Bota, Simona, E-mail: bota_simona1982@yahoo.com; Gradinaru-Taşcău, Oana, E-mail: bluonmyown@yahoo.com; Şirli, Roxana, E-mail: roxanasirli@gmail.com; Popescu, Alina, E-mail: alinamircea.popescu@gmail.com; Jurchiş, Ana, E-mail: ana.jurchis@yahoo.com

    2014-03-15

    Introduction: To identify liver stiffness (LS) cut-off values assessed by means of 2D-Shear Wave Elastography (2D-SWE) for predicting different stages of liver fibrosis, considering Transient Elastography (TE) as the reference method. Methods: Our prospective study included 383 consecutive subjects, with or without hepatopathies, in which LS was evaluated by means of TE and 2D-SWE. To discriminate between various stages of fibrosis by TE we used the following LS cut-offs (kPa): F1-6, F2-7.2, F3-9.6 and F4-14.5. Results: The rate of reliable LS measurements was similar for TE and 2D-SWE: 73.9% vs. 79.9%, p = 0.06. Older age and higher BMI were associated for both TE and 2D-SWE with the impossibility to obtain reliable LS measurements. Reliable LS measurements by both elastographic methods were obtained in 65.2% of patients. A significant correlation was found between TE and 2D-SWE measurements (r = 0.68). The best LS cut-off values assessed by 2D-SWE for predicting different stages of liver fibrosis were: F ≥ 1: >7.1 kPa (AUROC = 0.825); F ≥ 2: >7.8 kPa (AUROC = 0.859); F ≥ 3: >8 kPa (AUROC = 0.897) and for F = 4: >11.5 kPa (AUROC = 0.914). Conclusions: 2D-SWE is a reliable method for the non-invasive evaluation of liver fibrosis, considering TE as the reference method. The accuracy of 2D-SWE measurements increased with the severity of liver fibrosis.

  8. Which are the cut-off values of 2D-Shear Wave Elastography (2D-SWE) liver stiffness measurements predicting different stages of liver fibrosis, considering Transient Elastography (TE) as the reference method?

    Introduction: To identify liver stiffness (LS) cut-off values assessed by means of 2D-Shear Wave Elastography (2D-SWE) for predicting different stages of liver fibrosis, considering Transient Elastography (TE) as the reference method. Methods: Our prospective study included 383 consecutive subjects, with or without hepatopathies, in which LS was evaluated by means of TE and 2D-SWE. To discriminate between various stages of fibrosis by TE we used the following LS cut-offs (kPa): F1-6, F2-7.2, F3-9.6 and F4-14.5. Results: The rate of reliable LS measurements was similar for TE and 2D-SWE: 73.9% vs. 79.9%, p = 0.06. Older age and higher BMI were associated for both TE and 2D-SWE with the impossibility to obtain reliable LS measurements. Reliable LS measurements by both elastographic methods were obtained in 65.2% of patients. A significant correlation was found between TE and 2D-SWE measurements (r = 0.68). The best LS cut-off values assessed by 2D-SWE for predicting different stages of liver fibrosis were: F ≥ 1: >7.1 kPa (AUROC = 0.825); F ≥ 2: >7.8 kPa (AUROC = 0.859); F ≥ 3: >8 kPa (AUROC = 0.897) and for F = 4: >11.5 kPa (AUROC = 0.914). Conclusions: 2D-SWE is a reliable method for the non-invasive evaluation of liver fibrosis, considering TE as the reference method. The accuracy of 2D-SWE measurements increased with the severity of liver fibrosis

  9. Predictive Values of Body Mass Index and Waist Circumference for Risk Factors of Certain Related Diseases in Chinese Adults - Study on Optimal Cut-off Points of Body Mass Index and Waist Circumference in Chinese Adults

    2002-01-01

    For prevention of obesity in Chinese population, it is necessary to define the optimal range of healthy weight and the appropriate cut-off points of BMI and waist circumference for Chinese adults. The Working Group on Obesity in China under the support of International Life Sciences Institute Focal point in China organized a meta-analysis on the relation between BMI, waist circumference and risk factors of related chronic diseases (e. g.,high diabetes, diabetes mellitus, and lipoprotein disorders). Methods 13 population studies in all met the criteria for enrollment, with data of 239 972 adults (20-70 year) surveyed in the 1990s. Data on waist circumference was available for 111411 persons and data on serum lipids and glucose were available for more than 80 000. The study populations located in 21provinces, municipalities and autonomous regions in mainland China as well as in Taiwan. Each enrolled study provided data according to a common protocol and uniform format. The Center for data management in Department of Epidemiology, Fu Wai Hospital was responsible for statistical analysis. Results and conclusion The prevalence of hypertension, diabetes, dyslipidemia and clustering of risk factors all increased with increasing levels of BMI or waist circumference. BMI at 24 with best sensitivity and specificity for identification of the risk factors, was recommended as the cut-off point for overweight, BMI at 28 which may identify the risk factors with specificity around 90 % was recommended as the cut-off point for obesity. Waist circumference beyond 85 cm for men and beyond 80 cm for women were recommended as the cut-off points for central obesity.Analysis of population attributable risk percent illustrated that reducing BMI to normal range (<24) could prevent 45%-50% clustering of risk factors. Treatment of obese persons (BMI ≥ 28)with drugs could prevent 15%-17% clustering of risk factors. The waist circumference controlled under 85 cm for men and under 80 cm for

  10. Waterlow量表对重症患者压疮的预测价值及诊断界值分析%Predictive Value of Waterlow Scale for Pressure Ulcers for Critically Ill Patients and Its Cut-off Value

    李晓艳; 赵小利; 韩娟; 石秦东; 李昊

    2015-01-01

    目的:界定Waterlow量表对重症患者压疮的预测价值及诊断界值。方法回顾性分析765例重症患者的压疮风险评估资料,使用受试者工作特征(ROC)曲线评价Waterlow量表的预测性能和最佳诊断界值。结果由ROC分析结果可知,Waterlow评分曲线下面积为0.694,与0.5相比,具有统计学意义(P<0.01)。 Waterlow量表分界值为20分时,其灵敏度(0.880)、特异度(0.480)具有最好的平衡性。结论 Waterlow量表在预测重症患者压疮中具有较高的灵敏度和特异度,可将分界值提高至20分。%Objective To explore the predictive value of Waterlow scale for pressure ulcers for critically ill patients and its cut-off value. Methods A retrospective analysis of evaluation data of pressure ulcer risk of 765 critically ill inpatients was conducted and predictive value and cut-off value of Waterlow scale was assessed by ROC (Receiver Operating Characteristic). Results ROC indicated that the area under curve was 0.694, which showed statistical significance ( P<0.01). When cut-off value of Waterlow sacle reached 20, the sensitivity (0.880) and specificity (0.480) of the scale reached a good balance. Conclusion Waterlow scale has high sensitivity and specificity in predicting pressure ulcers for critically ill patients and its cut-off value could be raised to 20.

  11. Test accuracy at different cut-offs when plasma concentrations of metabolic indicators are used to detect decreased fertility in dairy cows (Poster topic 01, Poster 27, p. 193)

    Lomander, H; Gustafsson, H; Svensson, C;

    and BHBA were calculated and compared to each cow’s fertility status, measured as anestrous (ANEST) and delayed first AI (DFAI). Positive and negative predictive values (PV+; PV-) were calculated considering different levels of decreased fertility. Strata-specific Se and Sp and associations between...... test results and fertility parameters were investigated using logistic regressio n. For this analysis, cut-offs with Sp ~80% was used because a high Sp was considered of interest. This corresponded to a NEFA-cutoff at 400 µeqv./mL (Se≤0.44) and a BHBA-cut-off at 1.8 mM (Se ≤0.32). Sp was generally...... higher when the test was used in heifers compared to older cows. With a prevalence of ANEST of 28% PV+ were 0.25 and PV- nearly 0.90. With a DFAI prevalence of 35%, PV+ were <0.38 and PV- nearly 0.90. The results indicate that overall test performance is low when metabolic indicators measured 0-21 days...

  12. Thickness-Independent Ultrasonic Imaging Applied to Abrasive Cut-Off Wheels: An Advanced Aerospace Materials Characterization Method for the Abrasives Industry. A NASA Lewis Research Center Technology Transfer Case History

    Roth, Don J.; Farmer, Donald A.

    1998-01-01

    Abrasive cut-off wheels are at times unintentionally manufactured with nonuniformity that is difficult to identify and sufficiently characterize without time-consuming, destructive examination. One particular nonuniformity is a density variation condition occurring around the wheel circumference or along the radius, or both. This density variation, depending on its severity, can cause wheel warpage and wheel vibration resulting in unacceptable performance and perhaps premature failure of the wheel. Conventional nondestructive evaluation methods such as ultrasonic c-scan imaging and film radiography are inaccurate in their attempts at characterizing the density variation because a superimposing thickness variation exists as well in the wheel. In this article, the single transducer thickness-independent ultrasonic imaging method, developed specifically to allow more accurate characterization of aerospace components, is shown to precisely characterize the extent of the density variation in a cut-off wheel having a superimposing thickness variation. The method thereby has potential as an effective quality control tool in the abrasives industry for the wheel manufacturer.

  13. Determination of D-Dimers in condition of emergency: the D-Di Liatest. Threshold value in elimination of pulmonary emboli (PE); Determination en urgence des D-Dimeres: le liatest D-DI. Valeur seuil permettant d`eliminer une embolie pulmonaire (EP)

    Duet, M. [Service de Medecine Nucleaire (France); Soria, C. [Service de Hematologie (France); Elkarrat, D. [Service de Urgences (France); Benelhadj, S. [Service de Medecine Nucleaire (France); Bailliard, O.; Kedra, A.W. [Service de Explorations Founctionnelles, Hopital Lariboisiere, Paris (France); Drouet, L. [Service de Hematologie (France); Mundler, O. [Service de Medecine Nucleaire (France)

    1997-12-31

    Several studies have shown that a low rate of D-Dimers (products of fibrin decay) measured by Elisa technique can eliminate the diagnosis of thrombo-embolic disease. However, the conventional Elisa technique is not adapted to emergency conditions. A new agglutination test of latex microparticles (D-Di Liatest) has been developed by Diagnostica Stago with a sensitivity of 100 ng/ml. Our goal was to determine the threshold of PE exclusion. Ninety six patients suspected of PE were included. The pulmonary perfusion scintigraphy (PPS), as a reference examination the positivity of which has been confirmed by clinical follow-up, has been carried out in association with the determination of plasmatic rates of D-Dimers by the techniques Elisa and Liatest based on different antibodies. A table is given containing the D-Di threshold rates obtained by these techniques. In conclusion, our results showed that the rate of D-Dimers which eliminate a PE is {<=} 500 ng/ml by Elisa and {<=} 400 ng/ml by Liatest with a VPN of 100%. However, the PPS remains necessary in 77% of cases. This work stresses the necessity of clinical validations for the new biological tests

  14. Clinical Significance of Fibrinogen and D-dimer Detection in Esophageal Cancer%食管癌患者纤维蛋白原与D-二聚体检测的临床意义

    刘瑜; 林晓铭; 池闯; 程德志

    2012-01-01

    目的 检测并研究食管癌患者血浆中纤维蛋白原(FIB)和D-二聚体(D-dimer,DD)的变化及其临床意义.方法 对60例食管癌患者和8例健康人血浆中FIB和D-二聚体进行检测并同临床指标间进行统计学分析.结果 食管癌组血浆中的FIB和D-二聚体水平明显高于正常对照组(P<0.01);同患者的淋巴结转移情况及P-TNM分期有关(P <0.05或P<0.01),而同性别及年龄不相关(P>0.05).结论 食管癌患者的FIB及D-二聚体高于正常,并同淋巴结转移及P-TNM分期相关且与患者的生存期呈明显的负相关.%Objective To explore the clinical significance of fibrinogen and D - dimer detection in esophageal squamous cell cancer. Methods The fibrinogen and D - dimer were detected in 60 esophageal cancer patients and 8 healthy adults, and the data were analyzed with clinical indexes by SPSS. Results Levdel of fibrinogen and D - dimer in esophageal cancer patients were higher than that in healthy group (P 0. 05 ). Conclusion Compared with healthy group, significantly higher serum fibrinogen and D - dimer levels were detected in esophageal cancer patients. There was closely relationship between fibrinogen and D - dimer levels in esophageal cancer patients and lymph node metastases, p - TNM stage,and they were negatively correlated with lifetime.

  15. Examining the relationship between autistic traits and college adjustment.

    Trevisan, Dominic; Birmingham, Elina

    2016-08-01

    We examined the relationship between characteristics associated with autism spectrum disorder and college adjustment in a sample of neurotypical college students. Using the Broad Autism Phenotype Questionnaire and the Student Adaptation to College Questionnaire, we found that higher levels of autism spectrum disorder characteristics were associated with poorer adjustment to college. One subscale of the Broad Autism Phenotype Questionnaire, pragmatic language difficulties, explained the most variance in adjustment. In addition, students who met the previously established cut-off scores for possessing the broad autism phenotype scored significantly lower on all Student Adaptation to College Questionnaire subscales. Finally, pragmatic language difficulties mediated the relationship between college major and academic adjustment. These findings underscore the need for future research to examine how pragmatic language difficulties may impede college success in students with autism spectrum disorder and in the typical population. PMID:26471426

  16. 四川省新生儿 CH筛查切值的探讨%Exploration of cut-off value of TSH during screening of congenital hypothyroidism in the newborns in Sichuan

    周婧瑶; 欧明才; 罗晓菊; 张钰; 胡琦; 陈雪莲; 杨丽娟; 王蕊; 李婷

    2013-01-01

    目的:探讨四川省新生儿疾病筛查中心实验室先天性甲状腺功能减低症( CH)筛查切值,减少漏诊率,降低假阳性率。方法对四川省新生儿疾病筛查中心片区市县2011至2012年活产婴儿出生72小时并充分哺乳6次后取其足跟血,采用时间分辨荧光免疫法检测血中促甲状腺激素( TSH)浓度。结果2011至2012年度共测定525941例标本,其TSH浓度呈偏态分布,其中正常新生儿人数为525554,确诊CH患儿230例,高TSH血症患儿157例。当筛查切值定为8.0mIU/L和定为8.9mIU/L时,灵敏度χ2=10.188,P<0.05;特异度χ2=458.460,P<0.05,制定出四川省新生儿疾病筛查中心实验室时间分辨荧光免疫法筛查CH参考切值为8.0mIU/L。结论四川省新生儿疾病筛查中心制定的CH筛查切值是适宜的、有依据的,为更大规模开展的新生儿CH筛查提供了决策依据。%Objective To explore the positive cut-off value in neonatal screening for congenital hypothyroidism (CH) in the Centre of Neonatal Screening of Sichuan , so as to improve screening efficiency and reduce false positive rate .Methods DELFIA was applied to detect the concentration of thyroid-stimulating hormone ( TSH) in heel blood samples which were collected from the newborns 72 hours after birth and having drunk enough milk for at least 6 times.These neonates were born in 2011-2012 in counties and cities managed by the Centre of Neonatal Screening of Sichuan .Results Totally 525 941 blood samples were screened . The TSH concentration showed a skewed distribution .Among them 525 554 newborns were normal , 230 neonates were diagnosed with CH , and 157 with high TSH hyperlipidemia . When the positive cut-off value was 8.0mIU/L and 8.9mIU/L, the sensitivity χ2 was 10.188 ( P <0.05 ) and the specificity χ2 was 458.460 (P<0.05).The cut-off value of screening was 8.0mIU/L by DELFIA in the Centre of Neonatal Screening of Sichuan

  17. Prevalence of swallowing and speech problems in daily life after chemoradiation for head and neck cancer based on cut-off scores of the patient-reported outcome measures SWAL-QOL and SHI.

    Rinkel, Rico N; Verdonck-de Leeuw, Irma M; Doornaert, Patricia; Buter, Jan; de Bree, Remco; Langendijk, Johannes A; Aaronson, Neil K; Leemans, C René

    2016-07-01

    The objective of this study is to assess swallowing and speech outcome after chemoradiation therapy for head and neck cancer, based on the patient-reported outcome measures Swallowing Quality of Life Questionnaire (SWAL-QOL) and Speech Handicap Index (SHI), both provided with cut-off scores. This is a cross-sectional study. Department of Otolaryngology/Head and Neck Surgery of a University Medical Center. Sixty patients, 6 months to 5 years after chemoradiation for head and neck squamous cell carcinoma. Swallowing Quality of Life Questionnaire (SWAL-QOL) and SHI, both validated in Dutch and provided with cut-off scores. Associations were tested between the outcome measures and independent variables (age, gender, tumor stage and site, and radiotherapy technique, time since treatment, comorbidity and food intake). Fifty-two patients returned the SWAL-QOL and 47 the SHI (response rate 87 and 78 %, respectively). Swallowing and speech problems were present in 79 and 55 %, respectively. Normal food intake was noticed in 45, 35 % had a soft diet and 20 % tube feeding. Patients with soft diet and tube feeding reported more swallowing problems compared to patients with normal oral intake. Tumor subsite was significantly associated with swallowing outcome (less problems in larynx/hypopharynx compared to oral/oropharynx). Radiation technique was significantly associated with psychosocial speech problems (less problems in patients treated with IMRT). Swallowing and (to a lesser extent) speech problems in daily life are frequently present after chemoradiation therapy for head and neck cancer. Future prospective studies will give more insight into the course of speech and swallowing problems after chemoradiation and into efficacy of new radiation techniques and swallowing and speech rehabilitation programs. PMID:26071622

  18. COPD患者D-二聚体和纤维蛋白原检测的临床价值%The clinical value of D-Dimer and plasma fibrinogen in patients with chronic obstructive pulmonary disease

    周洋; 龚建化; 黄河; 张家洪

    2012-01-01

    目的 探讨COPD患者血浆D-二聚体和纤维蛋白原检测的临床意义.方法 分别检测122例按病情严重程度分期、分度的COPD患者和30例健康对照组血浆D-二聚体和纤维蛋白原含量,分析比较各组间血浆D-二聚体和纤维蛋白原含量的差异.结果 COPD患者血浆D-二聚体和纤维蛋白原含量明显高于健康对照组(P<0.05),且急性加重期明显高于稳定期(P<0.05).在75例急性加重期COPD患者中,轻、中、重、极重度患者其血浆D-二聚体和纤维蛋白原含量间相互比较(P<0.05).结论 COPD患者存在血液高凝状态,且随着病情的加重而加重,对其监测和预防性使用抗凝、溶栓剂是非常必要的.%Objective To investigate the clinical significance of the level of plasma D-dimer and plasma fibrinogen in patients with COPD. Methods According to severity stage, the plasma D-dimer and plasma fibrinogen level were measured in 122 patients with COPD. 30 healthy subjects were included as controls. All the measures of D-dimer and plasma fibrinogen were compared between the groups. Results The levels of D-dimer and fibrinogen in 122 patients were significantly higher than those in the control group (P < 0.05 ) , and the levels of D-dimer and fibrinogen in the acute exacerbation were significantly higher than those in the stable. In 75 patients with acute exacerbation of COPD patients, the levels of plasma D-dimer and fibrinogen in mild, moderate, severe and critical patients were compared, and the group differences were statistically significant (P < 0. 05 ). Conclusion The patients with COPD are in a state of hy-percoagulability, and the levels of plasma D-dimer and fibrinogen are related to the severity of COPD attack. To monitor and preventively use anticoagulant, the use of thrombolytic agent is necessary.

  19. Membrane molecular weight cut off impacts immunological safety of a novel bioartificial liver system%膜截流分子量在新型生物人工肝免疫安全性中的作用研究

    张悦; 施晓雷; 韩冰; 顾劲扬; 褚薛慧; 肖江强; 任昊桢; 檀家俊; 丁义涛

    2012-01-01

    Objective To investigate the influence of membrane molecular weight cut off in our bioartificial liver(BAL)system.Methods Beagle dogs were used for a model of acute liver failure through D-galactosamine administration.The acute liver failure Beagles were divided into two groups by the membrane molecular weight cut off.Group A was treated with BAL containing 200 kDa retention rating membrane.Group B was treated with BAL containing 1200 kDa retention rating membrane.Each group underwent two six-hour BAL treatments that were performed on day 1 and day 21.BAL medium were examined and levels of IgG,IgM,and complement hemolytic unit of 50%(CH50)antibodies were measured in all Beagles and.Results BAL treatment was associated with a significant decline in levels of CH50.1200 kDa group experienced a significant increase in levels of IgG and IgM after two BAL treatments.Significant levels of canine proteins were detected in BAL medium from 1200 kDa group.Conclusions Xenogeneic immune response in the BAL system was influenced by membrane molecular weight cut off.%目的 探讨膜截流分子量对新型生物人工肝(bioartificial liver,BAL)支持系统免疫安全性的影响.方法 应用D氨基半乳糖静脉滴注比格犬建立肝功能衰竭模型.急性肝功能衰竭犬根据BAL隔离膜截流分子量的大小分为两组:A组:200 kD组;B组:1200 kD组.两组均接受新型2次BAL治疗,每次6h.观察各组体内IgG、IgM、50%补体溶血单位(CH50)变化及反应器内抗体漏过情况.结果 在第一次BAL治疗后两组的IgG和IgM水平均没有发生明显的变化.在第2次治疗后第7天,1200 kD组的IgG和IgM水平明显升高,200 kD组IgG和IgM水平仍未出现明显上升或下降.在第一次BAL治疗后,两组CH50都出现暂时性的下降,在治疗后1h达到最低值,而后缓步上升,在7d后恢复至治疗前水平.反应器内培养液中IgG、IgM及CH50检测结果显示,1200 kD组在治疗结束后IgG、IgM及CH50

  20. 应用ROC曲线评价癌症患者心理压力量表的临界值研究%Using ROC curve to evaluate cut-off points of Psychological Distress Scale of Cancer Patients

    张丽燕; 陆宇晗

    2016-01-01

    目的:应用ROC曲线测定癌症患者心理压力量表各维度的临界值,为临床应用提供依据。方法调查北京肿瘤医院的癌症患者364例,填写癌症患者心理压力量表和症状自评量表(SCL-90),应用ROC曲线探索此量表各维度的临界值。结果以SCL-90相应维度为参照标准,癌症患者心理压力量表各维度ROC曲线下面积分别为:焦虑(0.815,P<0.01),抑郁(0.790,P<0.01),人际障碍(0.829,P<0.01),怀疑(0.670,P<0.01)。各维度在以下临界值时可获得最佳的敏感性和特异性:焦虑11分,抑郁14分,人际障碍7分,怀疑4分。结论癌症患者心理压力量表对焦虑、抑郁、人际障碍有较好的诊断价值,对怀疑的诊断价值较弱。它具有较好的诊断价值,有助于临床进行癌症患者的心理问题评价。%Objective To determine the cut-off points of Psychological Distress Scale of Cancer Patients by using the ROC curve, in order to provide reference for clinical application of it. Methods A questionnaire containing both the Psychological Distress Scale of Cancer Patients and Symptom Checklist-90 (SCL-90) were filled by 364 cancer patients in Beijing Cancer Hospital. Later the cut-off points of the four latitudes of the Scale were evaluated by ROC curve through comparing the two scales. Results By using the latitudes of the SCL-90 scale as a reference, the areas of all the four latitudes of the Scale were:anxiety (0.815, P<0.01); depression (0.790, P<0.01); interpersonal disability (0.829, P<0.01);suspiciousness (0.670, P<0.01) respectively. The following cut-off points could result in the most ideal sensitivity and specificity: 11 for anxiety; 14 for depression; 7 for interpersonal disability and 4 for suspiciousness. Conclusions The Psychological Distress Scale of Cancer Patients can provide great values to the diagnosis of psychological problems related with anxiety, depression, and interpersonal

  1. A quasi-discreteness approximation is employed to study analytically spatially localized voltage oscillations in a discrete electrical lattice. We show that the system may support new types of gap solitons as well as upper cut-off solitons (intrinsic localized modes), both nonlinear localized modes having a zero group velocity

    A quasi-discreteness approximation is employed to study analytically spatially localized voltage oscillations in a discrete electrical lattice. We show that the system may support new types of gap solitons as well as upper cut-off solitons (intrinsic localized modes), both nonlinear localized modes having a zero group velocity. (author)

  2. D-二聚体水平在系统性红斑狼疮的临床意义%The clinical significance of D-dimer in systemic lupus erythematosus

    李春; 穆荣; 任立敏; 范文强; 任长吉; 栗占国

    2010-01-01

    目的 了解系统性红斑狼疮(SLE)患者D-二聚体水平及其临床意义.方法 选北京大学人民医院住院的261例SLE患者,收集临床及实验室资料,分析D-二聚体水平及其与SLE患者临床特征及实验室检查指标的相关性.结果 (1)除外合并肾功能不全、严重感染、弥漫性血管内凝血(DIC)、肝功能异常、妊娠及外伤等可能影响D-二聚体水平的因素,261例SLE患者中入选205例,其中D-二聚体水平升高者达69.3%(142/205).(2)D-二聚体水平升高与SLE疾病活动指数(SLEDAI)评分呈正相关(r=0.598,P=0.000),并与抗双链DNA抗体阳性、C反应蛋白(GRP)升高、补体C3、补体C4降低等有一定相关性.(3)D-二聚体水平升高者脏器损伤比例增加,狼疮性肾炎(58.5%比38.1%)、神经精神性狼疮的发生率(18.3%比4.8%)明显高于D-二聚体水平正常者.(4)伴有血栓形成的SLE患者均有D-二聚体水平升高,但不合并血栓形成者D-二聚体水平升高或正常.结论 D-二聚体水平升高可见于SLE活动期及有重要脏器损伤者,并不必然提示血栓形成.但是,伴发血栓形成的SLE患者均有D-二聚体升高.%Objective To investigate the clinical significance of D-dimer in systemic lupus erythematosus (SLE). Methods The study group comprised 261 SLE patients who were admitted in ward from 2005 to 2008 in Peking University People's Hospital Collect the clinical data to investigate the clinical significance of D-dimer. Results ( 1 ) The D-dimer levels of 56 patients were increased due to coexist reduced renal function, infections, disseminated intravascular coagulation ( DIC), liver disorders, pregnancy and injury. With the exception of above patients, 142 ( 69. 3 ) patients were increased in total 205 patients. (2)The level of D-dimer was positively correlated with SLE disease activity index( SLEDAI ) score ( r =0. 598,P =0. 000), and was associated with anti-dsDNA antibody, ESR, C-reactive protein(CRP) and complement C3

  3. Pressurized liquid extraction for the determination of cannabinoids and metabolites in hair: Detection of cut-off values by high performance liquid chromatography-high resolution tandem mass spectrometry.

    Montesano, Camilla; Simeoni, Maria Chiara; Vannutelli, Gabriele; Gregori, Adolfo; Ripani, Luigi; Sergi, Manuel; Compagnone, Dario; Curini, Roberta

    2015-08-01

    Hair analysis has become a routine procedure in most forensic laboratories since this alternative matrix presents clear advantages over classical matrices; particularly wider time window, non-invasive sampling and good stability of the analytes over time. There are, however, some major challenges for the analysis of cannabinoids in hair, mainly related to the low concentrations of 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THC-COOH), that is the major metabolite. In this study a fast, accurate and sensitive method for the determination of cannabinol, cannabidiol, THC and THC-COOH in hair has been developed. The extraction of analytes from hair (50mg) is based on an automated pressurized liquid extraction (PLE) using water modified with the surfactant sodium dodecyl sulphate as eluent phase. PLE extract is then cleaned up by SPE using polymeric reversed phase cartridges Strata XL before the injection in the HPLC-HRMS/MS system. Chromatographic conditions obtained with a fused-core column allowed a good separation of the analytes in less than 4min. The whole procedure has been validated according to SWGTOX guidelines. The LLOQs obtained for THC-COOH and the other analytes were respectively 0.1 and 2pg/mg. To the best of our knowledge, this is the first LC-MS/MS based method that allows the detection of THC-COOH in hair at values lower than the cut-off. PMID:26118805

  4. ADJUSTMENT FACTORS AND ADJUSTMENT STRUCTURE

    Tao Benzao

    2003-01-01

    In this paper, adjustment factors J and R put forward by professor Zhou Jiangwen are introduced and the nature of the adjustment factors and their role in evaluating adjustment structure is discussed and proved.

  5. Cutting off Mediation. Agamben as Master Thinker

    Astrid Deuber-Mankowsky

    2015-02-01

    Full Text Available Agamben’s Homo Sacer turns centrally upon “bare life”. However, the following subjects are not thematized: natality, gender, sexuality, the relation of the sexes, the heterosexual character of the symbolic order and political culture, the interest of women in the reproduction of life. The entire question of sexual difference —like that of the difference between victim and perpetrator, between witnesses and those born afterwards— is banned from Agamben’s horizon. Thus a deep unease remains, which this paper is intended to explore. It will first present the methodological and theoretical inspirations, which Homo Sacer owes to the thought of Carl Schmitt. Secondly it will show that Schmitt’s concepts of nomos and the state of exception cannot provide a suitable basis for rewriting Foucault’s concept of biopolitics.

  6. Study on the change and relationship between plasma D-dimer and homocysteine levels in patients with acute cerebral vascular accident

    Objective: To study the clinical significance of the changes and the relationships between plasma D-dimer (D-D) and Homocysteine (Hcy) expression in patients with acute cerebral infarction and acute cerebral hemorrhage. Methods: Plasma D-D (with ELISA) and Hcy (with CLIA) levels were measured in 397 patients with cerebral infarction, 122 patients with cerebral hemorrhage and 30 controls.Results 1) The mean level of the plasma D-D and Hcy in patients with acute cerebral infarction was 5.20±0.92μg/L and 21.23±13.54 μmol/L respectively, which was significant higher than that in controls and patients with acute cerebral hemorrhage. 2) Higher expressing of D-D and Hcy was found in 101 (25.4%) and 140 (35.3%) cases of acute cerebral infarction patients. The data in acute cerebral hemorrhage group was 17 (13.9%) and 27 (22.1%) respectively. There was significant difference between two groups, P<0.01. 3) There was not correlations with the expression level of D-D and Hcy in patients with acute cerebral infarction and patients with acute cerebral hemorrhage. 4) The expressing level of the Plasma D-D in acute cerebral infarction patients was not significant difference in both age and sex. The expressing level of Hcy in male was higher than that in female. There was not significant difference in the expressing level of Hcy in different age. Conclusion: The levels of plasma D-D and Hcy in patients with acute cerebral infarction significantly in creased, but there were not correlations between the levels of the two parameters. (authors)

  7. D-Dimer plasma levels in patients with coronary artery disease Níveis plasmáticos de Dímero D em pacientes com doença arterial coronariana

    Luciana M. Lima; Marinez O. Sousa; Ana Paula Fernandes; Adriano P. Sabino; Cirilo P. Fonseca Neto; José Carlos F. Garcia; Jamil A. Saad; Maria das Graças Carvalho

    2006-01-01

    We have previously reported that prothrombin fragment 1+2 levels were not associated to the presence or severity of coronary artery disease (CAD) and do not provide further information on subjects with CAD diagnosed by angiography. Thus, in the present study another marker of hypercoagulability was evaluated in the same subjects. This study aimed at determining D-Dimer plasma levels in a group of subjects undergoing coronary angiography to establish a likely relation between this parameter an...

  8. Comparison of VerifyNow-P2Y12 test and Flow Cytometry for monitoring individual platelet response to clopidogrel. What is the cut-off value for identifying patients who are low responders to clopidogrel therapy?

    Castelli Alfredo

    2009-05-01

    Full Text Available Abstract Background Dual anti-platelet therapy with aspirin and a thienopyridine (DAT is used to prevent stent thrombosis after percutaneous coronary intervention (PCI. Low response to clopidogrel therapy (LR occurs, but laboratory tests have a controversial role in the identification of this condition. Methods We studied LR in patients with stable angina undergoing elective PCI, all on DAT for at least 7 days, by comparing: 1 Flow cytometry (FC to measure platelet membrane expression of P-selectin (CD62P and PAC-1 binding following double stimulation with ADP and collagen type I either in the presence of prostaglandin (PG E1; 2 VerifyNow-P2Y12 test, in which results are reported as absolute P2Y12-Reaction-Units (PRU or % of inhibition (% inhibition. Results Thirty controls and 52 patients were analyzed. The median percentage of platelets exhibiting CD62P expression and PAC-1 binding by FC evaluation after stimulation in the presence of PG E1 was 25.4% (IQR: 21.4–33.1% and 3.5% (1.7–9.4%, respectively. Only 6 patients receiving DAT (11.5% had both values above the 1st quartile of controls, and were defined as LR. Evaluation of the same patients with the VerifyNow-P2Y12 test revealed that the area under the receiver-operating-characteristic (ROC curve was 0.94 (95% CI: 0.84–0.98, p 213 PRU gave the maximum accuracy for the detection of patients defined as having LR by FC. Conclusion In conclusion our findings show that a cut-off value of ≤ 15% inhibition or > 213 PRU in the VerifyNow-P2Y12 test may provide the best accuracy for the identification of patients with LR.

  9. Feed Cam Mechanism Design of Cut-off Saws Based on ANSYS%基于ANSYS的林间锯段机进料凸轮机构设计

    战丽; 宫乙帅; 王毅亮

    2012-01-01

    A feeding mechanism is one of the main components of forest self-propelled small-scale cut-off saws, and its rational design determines the efficiency of the entire cutting process. The exact cutting speed is determined through the comparative analysis of theoretical calculation and actual processing empirical value, based on which feed speed is calculated. In order to ensure steady processing, a feed cam is designed and finite element analysis of it is made using ANSYS software to verify the stiffness and strength of the feed mechanism. The mechanism is rationally optimized in order to provide a theoretical basis for the design of the feed mechanism of sawing operation.%进料机构是林间自走式小型锯段机的主要部件之一,其设计的合理与否影响整个锯切加工过程。通过理论计算值与实际加工经验值的对比分析确定切削速度,进而计算出进料速度。为保证加工平稳设计了进料凸轮机构,并利用ANSYS软件对其进行有限元分析,验证凸轮机构的刚度与强度。对该结构进行合理优化,为锯切进料机构的设计提供理论依据。

  10. Body mass index cut-offs for overweight and obesity in Chinese children and adolescents aged 2-18 years%中国2~18岁儿童青少年超重和肥胖筛查体重指数界值点的研究

    李辉; 宗心南; 季成叶; 米杰

    2010-01-01

    Objective To study the body cut-offs of mass index (BMI) for the purpose of screening overweight and obesity for Chinese children and adolescents aged 2-18 years. Methods Based on the BMI growth reference values for Chinese children aged 0-18, using the common methods to establish the BMI cut-offs for screening overweight and obesity. These methods were having the same empirical percentile or Z scores and the BMI value at 18 years consistent with adults.Three sets of BMI cut-offs, including (BMI24, BMI28) , (P85, P95) and (Z1, Z2) , were initially identified. Differences were compared on different cut-off points and prevalence rates of overweight and obesity with different BMI reference, different values and "prevalence" of overweight and obesity based on "2004 Beijing Child and Adolescent Metabolic Syndrome Study ". Cut-offs standards which recommended by the Chinese Working Group on Obesity for Children (WGOC) and by the International Obesity Task Force (IOTF) were also used. Finally the appropriate cut-offs were defined. Results Three sets of BMI cut-offs for screening overweight and obesity for Chinese children and adolescents aged 2-18 years were obtained according to the above mentioned methods for selection. The prevalence rates of overweight and obesity defined by those cut-offs appeared not to be significantly different. Compared with the WGOC, the BMI cut-off points for screening overweight and obesity for both boys and girls from our study were very close to the WGOC', but cut-off points for screening overweight for girls aged 8.5-15.5 y was 0.3-1.0 kg/m2 lower than the WGOC'. Going through the database on screening of "2004 Beijing Children's Metabolic Syndrome Survey ", the prevalence of overweight for girls was about 3.4% higher than using the cut-offs of WGOC. Conclusion Results from this study suggested that the BMI cut-offs passed through the cut-off point of BMI24 and BMI28 at 18 years was appropriate for screening overweight and obesity in

  11. Convexity Adjustments

    M. Gaspar, Raquel; Murgoci, Agatha

    2010-01-01

    A convexity adjustment (or convexity correction) in fixed income markets arises when one uses prices of standard (plain vanilla) products plus an adjustment to price nonstandard products. We explain the basic and appealing idea behind the use of convexity adjustments and focus on the situations o...

  12. Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis Avaliação dos níveis séricos de D-dímeros entre doentes com urticária crônica, psoríase e urticária vasculite

    Paulo Ricardo Criado; Lidi Che Leon Antinori; Celina Wakisaka Maruta; Vitor Manoel Silva dos Reis

    2013-01-01

    BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE: To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with dis...

  13. Pontos de corte para a aptidão cardiorrespiratória e a triagem de fatores de risco para doenças cardiovasculares na infância Cardiorespiratory fitness cut offs points and cardiovascular risk factors screening at infancy

    Gabriel Gustavo Bergmann

    2010-10-01

    Full Text Available O principal objetivo deste estudo foi analisar a validade e propor novos pontos de corte para aptidão cardiorrespiratória de escolares de sete a 12 anos de idade. A amostra foi constituída por 1.413 escolares. A aptidão cardiorrespiratória foi medida através do teste de corrida/caminhada de nove minutos. O colesterol total e as pressões arterial sistólica e diastólica foram medidas e através delas foram criadas referências de fatores de risco para doenças cardiovasculares. Através da curva receiver operating characteristic entre a aptidão cardiorrespiratória e as referências de fatores de risco para doenças cardiovasculares foram identificados os valores dos pontos de corte. Adicionalmente foi utilizada a análise bivariada seguida do cálculo de razão de chances (odds ratio-OR para identificar quanto os indivíduos que não atenderam os pontos de corte propostos tinham a mais de chance de apresentar fatores de risco para doenças cardiovasculares. Os resultados indicaram que, dentre as propostas analisadas, a que foi sugerida neste estudo apresentou melhores ajustamentos entre sensibilidade e especificidade. Os resultados da análise bivariada mostraram que indivíduos que não atenderam os pontos de corte propostos têm maiores chances de apresentarem fatores de risco para doenças cardiovasculares.The main objective of the study was to analyze and propose news cardiorespiratory fitness cut offs points for 7 to 12-year old school students. The sample was composed of 1,413 students. Cardiorespiratory fitness was measured by the 9-minutes walking/running test. Total cholesterol and systolic and diastolic blood pressure were measured and with their results cardiovascular risk factors reference were designed. The Receiver Operating Characteristic curve between cardiorespiratory fitness and cardiovascular risk factors reference identified the cut offs point values. The bivariate analysis and odds ratio (OR calculation was used to

  14. 老年脓毒症患者血浆D-二聚体和降钙素原水平变化∗%The Changes of Plasma Levels of D-dimer and Procalcitonin in Elderly Patients with Sepsis

    杨勇文; 李从荣#

    2015-01-01

    目的::回顾性分析 D-二聚体和降钙素原水平在老年脓毒症患者中的变化。方法:将172例老年脓毒症患者按预后分为生存组(n=115)和死亡组(n=57);采用免疫比浊法和电化学发光法分别检测两组患者入院时血浆 D-二聚体和降钙素原水平,比较血浆 D-二聚体、降钙素原水平和急性生理与慢性健康状况评分(APACHEⅡ评分)的组间差异及其相关性。结果:生存组血浆 D-二聚体和降钙素原水平和 APACHEⅡ评分均低于死亡组(P<0.01);老年脓毒症患者血浆 D-二聚体和降钙素原水平与 APACHEⅡ评分存在明显正相关性(r 分别为0.352、0.234,P <0.05)。结论:不同预后的老年脓毒症患者血浆 D-二聚体和降钙素原水平存在差异,监测这两个生物学指标对老年脓毒症患者的预后具有一定的参考价值。%Objective:To analysis the changes of D-dimer,procalcitonin levels in elderly patients with sepsis. Method:1 72 cases of elderly patients with sepsis were divided into survival group (n=1 1 5)and death group (n=57).When patients admitted to hospital,immune turbidimetric method and electrochemical luminescence method were used respectively to detect the plasma D-dimer and procalcitonin levels.The plasma D-dimer,procalcitonin lev-els and acute physiology and chronic health evaluation (APACHE Ⅱ score)differences between groups and their correlation were analyzed.Results:Survival group of plasma D-dimer and procalcitonin levels and APACHE Ⅱscores were lower than the death group with statistical significance (P <0.01 ).Plasma D-dimer and procalcitonin levels and APACHE Ⅱ scores were significantly positive correlations (r = 0.352,0.234,P < 0.05 ).Conclusion:There were differences in plasma of D-dimer and procalcitonin levels of in the elderly sepsis patients with different prognosis.The two biological indicators had certain reference value for the prognosis of elderly patients with sepsis.

  15. 从scFv噬菌体库分离特异性的人源化抗D-dimer抗体%Isolation of specific humanized anti-D-dimer scFv fragments from scFv phage libraries

    夏红利; 谭最; 陈德杰; 乔建国; 邱仁峰

    2011-01-01

    目的 从scFv(单链Fv)噬菌体抗体库分离出对D-dimer有特异性的人源化单克隆scFv.方法 对Tomlinson scFv噬菌体文库进行3轮淘洗,富集特异性的抗D-dimer抗体并进行ELISA 验证.通过酶联免疫检测和双脱氧终止法基因测序,获取特异性的人源化单克隆抗体.结果 3轮淘洗选择出38个抗D-dimer噬菌体抗体,酶联免疫和基因测序分析后,20个不同的全长单克隆抗D-dimer scFv噬菌体抗体被筛选出来,3轮选择后阳性克隆获取率为100%;分泌性抗体ELISA结果显示单克隆anti-D-dimer噬菌体顺利表达了抗体蛋白;5个A450值较高的单克隆中,3个显示了对D-dimer的高特异性和亲和力.结论 抗体噬菌体展示技术是分离获取人源化特异性anti-D-dimer抗体的高效快速方法.%Objective To isolate specific humanized anti-D-dimer scFv(single chain Fv) antibody from scFv phage libraries. Methods Isolate anti-D-dimer positive clones from Tomlinson I + J phage libraries by three rounds of panuing, then sequence monoclonal genes by bideoxy-mediated chain termination and express soluble scFv antibody; Pick out anti-D-dimer antibodies with high specificity and affinity by ELISA.Results After three rounds of selection from human scFv phage libraries Tomlinson I and J, 38 monclonal specific anti-D-dimer scFv fragments were selected. By polyclonal and monoclonal phage ELISA and gene sequencing, 20 different full-length monoclonal scFv phages were identified, the result of soluble scFv ELISA showed that 20 full-length monoclonal scFv were expressed smoothly. According to the result of soluble scFv ELISA, in 5 scFv antibodies with high value of A450 selected, 3 scFv antibody fragments showed high specific and affinity. Conclusion Antibody phage display was an effective, rapid method to isolate anti-D-dimer antibodies with high specificity and affinity.

  16. 动态监测D-二聚体在产后抢救中的应用价值%The. Applied Value of Dynamic Monitoring the Level of D-dimer in the Patients with Postpartum Hemorrhage

    何卫恒; 周丽英; 吴昂

    2009-01-01

    Objective To dynamic monitor the level of D--dimer after transfusion treatment of postpartum hemorrhage and the possibility of thrombosis. Methods To retrospective analyze and compare of the level of D-dimer of 10 cases with postpartum hemorrhage, while the one in 20 eases of normal confinement in our hospital of year 2008. Results The level of D-dimer in the ease of postpartum hemorrhage was significantly higher than the one in the ease of normal confinement, and this difference indicated important significance(P<0.01).Dynamic monitoring 10 eases of emergency treatment of patients with plasma D-dimer levels with the effective condition improved after treatment and gradually decreased. Conclusion D-dimer is the main mark of secondary fibrinolysis, and the results reflect the function of D-dimer in vascular endothelial injury and blood coagulation, anti-coagulation and fibrinolytie. Furthermore, it has important significance in the understanding of the body's blood coagulation status and the prediction of mierothrombus formation, bleeding tendency, or the occurrence and development of disseminated intravaseular coagulation(DIC), development%目的 通过动态检测产后大出血输血治疗中的D-二聚体水平,以评估疗效及新鲜血栓形成的可能性.方法 回顾性分析2008年本院10例产后大出血抢救中的D-二聚体水平和凝血四项结果,同时检测20例正常分娩产妇的D-二聚体水平作对照分析,并采用t检验进行统计分析.结果 产后大出血抢救中的血浆D-二聚体水平显著高于正常对照组,差异有显著性(P<0.01).动态监测10例抢救患者的血浆D-二聚体水平随有效治疗病情好转后而逐渐降低.结论 D-二聚体是继发性纤溶标志,其检测结果能反映患者的血管内皮损伤及凝血、抗凝血和纤溶功能,对了解机体的血液凝固状态,预测是否有微血栓的形成和出血倾向,预测弥散性血管内凝血(DIC)发生、发展及患者的预后具有重要的临床价值.

  17. Sensitivität des D-Dimers zum Ausschluß venöser thromboembolischer Erkrankungen im klinischen Alltag

    Lohr G

    2007-01-01

    (falsch negative Rate 1,3 %. Die Sensitivität betrug hier 98,7 %. In unserer Arbeit zeigen sich im Vergleich D-Dimere alleine und Kombination D-Dimertest/KW mit verschiedenen Scoresystemen zwar nicht signifikante Unterschiede in den falsch negativen Ergebnissen, bei allerdings geringer Fallzahl. Die falsch negative Rate von 3,8 % bei alleiniger D-Dimertestung ist bei diesen potentiell tödlichen Erkrankungen hoch. Die Sensitivität und die Sicherheit der Ausschlußdiagnostik kann durch den Einsatz von Scoresystemen in Kombination mit D-Dimertests, die nicht invasiv sind, erhöht werden, und somit eine einfache, leicht durchzuführende und optimale Ergänzung darstellen.

  18. Pulmoner emboli tanısında D-dimer düzeyleri ile ventilasyon/perfüzyon sintigrafisindeki bulgular arasındaki ilişki

    Hasbek, Zekiye; Erselcan, Taner; Gül, Serdar Savaş

    2014-01-01

    Aim. Pulmonary embolism (PE) is a cardiovascular disease that the diagnosis is needed urgent recognition or exclusion, since the PE has high risk of death and anticoagulant treatment starting with suspicion of PE has high risk of bleeding. Ventilation/perfusion(V/P) scintigraphy is one of the widely used tests in suspect of PE. D-dimer is a product of fibrin degradation. However, it is not specific for acute thrombosis. The purpose of this study was to investigate the relation between number ...

  19. Comparison of PCT, CRP, D-Dimer, Lactate, TNF-α, IL-1β, IL-6 and lL-10 in Development of Systemic Inflammatory Response Syndrome and Sepsis on Patients with Isolated Head Trauma and Polytrauma

    Emine Dağlı; Ali Aydın Altunkan; Handan Birbiçer; Gülhan Orekeci Temel

    2012-01-01

    Objective: In this study, it was aimed to compare the relationship between Glasgow Coma Scale (GKS), ISS values, PCT, CRP, D-Dimer, laktat, TNF-α, IL-1β, IL-6, IL-10 in patients with polytrauma and isolated head trauma in conjunction with SIRS and sepsis. Material and Method: Total of 68 patients (32 polytrauma, 36 isolated head trauma) aged between 18-65 years were enrolled in the study. For 7 days of follow up, the biochemical parameters were analysed on the days 0, 1, 3, 5, 7 and the IS...

  20. A Method of Multi-channel Data Acquisition with Adjustable Sampling Rate

    Su Shujing

    2013-09-01

    Full Text Available Sampling rate of current signal acquisition systems are singular. Aiming at this shortcoming, a method of multi-channel data acquisition(DAQ with adjustable sampling rate is presented. The method realizes the cut-off frequency of anti-aliasing filter controlled by program with the help of switched-capacitor; by independently pulsing sampling signal of different ADCs, 16-channel sampling rate are adjustable within the range 50ksps, 25ksps, 10ksps, 5ksps, 1ksps. Theoretical analysis and experimental verification pointing at the proposed method are implemented: theoretical analysis shows that parameters of the filter meet the design requirements; experimental results show that cut-off frequency of the anti-aliasing filter matches variable sampling rate very well; choosing appropriate sampling rate according to the characteristics of the measured signal not only can well restore the measured signal, but also prevents system resources from waste. This method can meet needs of testing various signals with different frequency at the same time.  

  1. Adjustment disorder

    American Psychiatric Association. Diagnostic and statistical manual of mental disorders . 5th ed. Arlington, VA: American Psychiatric Publishing. 2013. Powell AD. Grief, bereavement, and adjustment disorders. In: Stern TA, Fava ...

  2. Adjustment disorder

    American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Arlington, Va: American Psychiatric Publishing. 2013. Powell AD. Grief, bereavement, and adjustment disorders. In: Stern TA, Rosenbaum ...

  3. 脊柱关节炎患者D-二聚体和纤维蛋白原检测临床意义初探%Detection and clinical significance of blood of D-Dimer and fibrinogen in spondyloarthritis

    王育凯

    2013-01-01

    Objective To detect the clinical significance of D-Dimer and fibrinogen in the blood of spondyloarthritis (SpA) patients.Methods D-Dimer and fibrinogen of blood were detected among 50 patients with SpA,rheumatoid arthritis (RA),and systemic lupus erythematosus (SLE).further to investigate the relationship of other factors,such as patient global score (PGS),doctor global score (DGS),erythrocyte sedimentation rate (ESR),C-reactvie protein (CRP),platelet (PLT),serum ferritin (SF),and Human Leucocyte Antigen-B27 (HLA-B27).Results The titer of D-Dimer in SpA was significantly lower than that of the RA and SLE group [(535 ±748),(3477 ±4808) and (1285 ±2131) μg/L respectively,P <0.05].The level of fibrinogen in three groups was no significant difference.PGS and DGS was higher in SpA patients with positive D-Dimer and fibrinogen than those with control group (P < 0.05).The values of ESR,CRP and SF in SpA patients with positive D-Dimer and fibrinogen were significantly higher than those in patients with control group.There was positive correlation between D-Dimer and fibrinogen and ESR (r =0.37 and 0.55 respectively,P < 0.01),CRP (r =0.54 and 0.54 respectively,P < 0.01),and DGS (r =0.13 and 0.19 respectively,P<0.01).D-Dimer had positive correlation with PGS (r=0.15,P<0.01).Conclusion The level of D-Dimer and fibrinogen in the blood of SpA patients in increased,and is positively correlated with disease activities.The results indicated that the activation of coagulation-fibrinolytic system may play a role in the pathogenesis of SpA.%目的 探讨检测D-二聚体和纤维蛋白原(Fib)在脊柱关节炎(SpA)患者中的临床意义.方法 比较50例SpA、50例类风湿关节炎(RA)和50例SLE患者血中D-二聚体和Fib水平.并研究其与患者总体评分(PGS)、医生总体评分(DGS)、ESR、CRP、血小板、铁蛋白、HLA-B27等指标的关系.结果 SpA组、RA组、SLE组的血D-二聚体水平分别为(535±748)、(3 477±4 808)和(1 285±2 131

  4. Comparison of PCT, CRP, D-Dimer, Lactate, TNF-α, IL-1β, IL-6 and lL-10 in Development of Systemic Inflammatory Response Syndrome and Sepsis on Patients with Isolated Head Trauma and Polytrauma

    Emine Dağlı

    2012-12-01

    Full Text Available Objective: In this study, it was aimed to compare the relationship between Glasgow Coma Scale (GKS, ISS values, PCT, CRP, D-Dimer, laktat, TNF-α, IL-1β, IL-6, IL-10 in patients with polytrauma and isolated head trauma in conjunction with SIRS and sepsis. Material and Method: Total of 68 patients (32 polytrauma, 36 isolated head trauma aged between 18-65 years were enrolled in the study. For 7 days of follow up, the biochemical parameters were analysed on the days 0, 1, 3, 5, 7 and the ISS, GCS score and growth rates of SIRS and sepsis were recorded. Results: It was demonstrated that for patients with isolated head trauma, SIRS (80.6%, sepsis (38.9% and mortality values (71.4% were higher and there is a statistically important linear and inverse relationship between ISS and GCS values (p<0.05. During sepsis and SIRS phases, CRP elevated in both groups, whereas PCT only in the polytrauma group. D-Dimer values were investigated high in both groups, but atypically decreased on day 3 in isolated head trauma group. Lactate, TNF-α and, IL-1β were within reference values, IL-6 and IL-10 values were elevated in both groups but were higher in the polytrauma group. Conclusion: Although multiple variations were detected in serum markers of pro-inflamatory and acute phase proteins, we thought that these are inadequate in predicting mortality and complications such as SIRS and sepsis.

  5. The Brazilian hazard-based cut-off criteria for pesticide registration: a critical appraisal / Critérios de exclusão baseados em perigo adotados no Brasil para registro de pesticidas: Uma avalição crítica

    Francisco José Roma Paumgartten

    2013-02-01

    Full Text Available Brazil, the world’s top consumer of agricultural pesticides, adopts a unique hazard-based cut-off approach to pesticide registration. Cut-off criteria for mutagenicity, carcinogenicity, teratogenicity, hormonal disturbances and damage to reproductive organs were introduced by the Pesticide Law enacted in 1989. As far as health is concerned, law enforcement is additionally regulated by rules issued by the federal health authority (National Agency for Health Surveillance – ANVISA. Contrasting to the European Union’s hazard-based cut-off criteria for pesticides, Brazilian rules do not make an exception for “negligible” exposures. Moreover, Brazilian regulations have shortcomings (e.g. no reference to relevance of Mode of Action to humans that make cut-off criteria difficult to be put into effect. The deficiencies of regulations and difficulties to consistently apply the hazard-based cut-off criteria are appraised in this article. Adoption of a risk assessment approach or cut-off criteria based on classification into the Globally Harmonized System’s hazard categories 1A and 1B is suggested. Resumo O Brasil, líder mundial do consumo de agro-químicos, adota uma singular abordagem para registro de agrotóxicos que é baseada em critérios de exclusão quanto à periculosidade. Critérios de exclusão para mutagenicidade, carcinogenicidade, teratogenicidade, distúrbios hormonais e dano a órgãos reprodutivos foram introduzidos pela Lei de Agrotóxicos promulgada em 1989. Em relação à saúde, a aplicação da lei é também regulada por portarias publicadas pela autoridade sanitária federal (Agência Nacional de Vigilância Sanitária – ANVISA. Em contraste com os critérios de exclusão baseados na periculosidade que a União Européia usa para agrotóxicos, a regulamentação brasileira não faz exceção para exposições insignificantes. Além disso, a regulamentação brasileira apresenta deficiências (e.g., não faz men

  6. Effects of neurofeedback on the level of D-dimer in patients with cerebral infarction%脑电生物反馈对脑梗死患者D-二聚体的影响

    刘文杰; 胡义奎

    2013-01-01

    目的 探讨超脑电生物反馈对脑梗死患者的纤溶系统指标D-二聚体(D-dimer)的影响. 方法 共选取发病72 h内入院的急性脑梗死患者126例,运用随机数字表法分为脑电生物反馈治疗组(治疗组)62例及常规治疗组(对照组)64例,2组患者均接受神经内科常规药物治疗,治疗组在常规治疗基础上给予脑电生物反馈治疗.所有患者在入院时及治疗2周后进行血浆D-二-聚体的检测及美国国立卫生院卒中量表(NIHSS)评分.结果 经2周治疗后,治疗组有效率(88.7%)明显优于常规治疗组(68.7%,P<0.05);2组患者入院时D-二聚体水平高于阴性对照组(P<0.05),2周后2组D-二聚体水平较入院时降低(P<0.05),且治疗组变化幅度较对照组显著(P<0.05). 结论 脑电生物反馈治疗能下调D-二聚体,对脑梗死患者的神经功能有显著改善作用.%Objective To investigate the effects of neurofeedback on the level of D-dimer in the patients with acute cerebral infarction. Methods All 126 patients with cerebral infarction within the first 72 h from stroke onset were randomly divided into the control group(64 cases) and therapy group(62 cases). All patients received routine treatment, and the patients in therapy group were given additional neurofeedback. In both groups, the plasma level of D-dimer was measured by double antibodies sandwich enzyme linked immunosorbent assay (ELISA) at the time of admission and 2 weeks later. According to National Institute of Health Stroke Scale (NIHSS) ,the effect was evaluated at the time of admission and 2 weeks later. Results The score of NIHSS and the level of D-dimer were significantly decreased after therapy in both groups. The efficacy in therapy group was more significant than that in control group (88. 7% vs 68. 7% ,P < 0. 05). Conclusions Neurofeedbak is effective in treating the acute cerebral infarction by decreasing the level of D-dimer.

  7. Dynamic analysis of plasma NT-ProBNP and D-dimer levels in acute pulmonary embolism%急性肺栓塞血浆NT-ProBNP与D-二聚体水平的动态分析

    白重阳; 吕晓丽; 苏征; 辛欢; 陈颖; 李斌; 张惠中

    2014-01-01

    目的:通过检测急性肺栓塞(APE)患者溶栓前后血浆氨基末端脑钠肽前体(NT-ProBNP)、D-二聚体水平,探讨其变化特点及意义。方法60例疑似APE患者,其中经CT确诊并符合溶栓条件的APE患者40例设为实验组,经CT排除APE患者20例为对照组。测定两组治疗前及实验组溶栓治疗2周后血浆 NT-ProBNP 与D-二聚体水平并进行比较。结果 NT-proBNP检测对早期APE患者的诊断灵敏度为92.3%,特异度为65%;D-二聚体检测对早期APE患者的诊断的灵敏度为100%,特异度为70%;实验组溶栓前血浆NT-ProBNP与D-二聚体水平显著高于对照组,差异有统计学意义(P<0.01)。结论血浆NT-ProBNP与D-二聚体对APE具有重要的临床意义,可为APE患者早期诊断及疗效观察提供依据。%Objective To detect plasma amino-terminal pro-brain natriuretic peptide (NT-ProBNP) ,D-Dimer levels in the pa-tients with acute pulmonary embolism (APE) in order to investigate their change characteristics and significance .Methods Among 60 patients with suspected APE ,40 cases diagnosed by CT and meeting the thrombolytic condition were set as the experimental group and other 20 cases of excluded APE by CT as the control group .Plasma NT-ProBNP and D-dimer before treatment in the two groups and after 2-week thrombolytic therapy in the experimental thrombolysis were detected and compared .Results The diagnos-tic sensitivity of NT-ProBNP for early APE was 92 .3% and the specificity was 65% ,while the diagnostic sensitivity of D-dimer for early APE was 100% and the specificity was 70% ;the plasma NT-ProBNP and D-dimer levels before thrombolysis in the experi-mental group were significantly higher than those in the control group with statistical differences (P<0 .01) .Conclusion Plasma NT-ProBNP and D-dimer has important clinical significance for APE and can provide the basis for the early diagnosis and the cura-tive effect observation of

  8. Amplitude no fósforo microbiano em um Argissolo em pastagem nativa submetida à roçada e à introdução de espécies forrageiras com fertilização fosfatada em diferentes épocas = Microbial phosphorus fluctuation in a Hapludalf under natural pasture, with cut off and forage species introduction, fertilized in different times

    Danilo dos Santos Rheinheimer

    2008-10-01

    Full Text Available Em solos com elevado grau de intemperismo, a imobilização temporária de fósforo pela biomassa microbiana do solo (BMS pode ser um mecanismo de retardamento das reações de adsorção. O objetivo do presente trabalho foi avaliar a amplitude no fósforo microbiano (Pmem um Argissolo em pastagem nativa submetida à roçada, introdução de forrageiras exóticas e adubadas com fertilizantes fosfatados. O estudo foi desenvolvido a partir de um experimento instalado em 1997 que constava de cinco tratamentos de fosfato e calagem (testemunha semfósforo; hiperfosfato de gafsa; superfosfato triplo; superfosfato triplo + calcário e superfosfato simples + calcário, distribuídos em quatro blocos ao acaso. Em junho de 2002, a pastagem nativaremanescente foi roçada, semeada a pastagem de inverno e as parcelas originais foram divididas em três subparcelas. A reposição dos fertilizantes fosfatados foi feita em três épocas, uma em cadasubparcela: sem reaplicação; reaplicação após a roçada da pastagem nativa remanescente (outonojunho; e reaplicação após a roçada da forrageira hibernal (primavera-novembro. A primeira avaliação do Pm foi feita 16 dias antes da primeira roçada, considerando o reinício doexperimento (0 dia. A partir daí, coletaram-se amostras de solo aos 25, 36, 55, 82, 111, 139, 163, 171, 181, 197, 219, 229, 248, 274 e 316 dias após o reinício do experimento. O corte das forrageiras induziu à imobilização de fósforo pela biomassa microbiana do solo. Parte do fósforo adicionado, via fertilizantes, foi imobilizado temporariamente pela biomassa microbiana do solo.In very weathered soils, the temporary phosphorus immobilization by soil microbial biomass (SMB could be a mechanism to reduce P adsorption. This study was carried out to evaluate the microbial phosphorus (Pm content fluctuation in a Hapludalf under natural pasture with cut off and exotic forage species introduction and fertilized with phosphorus fertilizers

  9. Salary adjustments

    HR Department

    2008-01-01

    In accordance with decisions taken by the Finance Committee and Council in December 2007, salaries are adjusted with effect from 1 January 2008. Scale of basic salaries and scale of stipends paid to fellows (Annex R A 5 and R A 6 respectively): increased by 0.71% with effect from 1 January 2008. As a result of the stability of the Geneva consumer price index, the following elements do not increase: a)\tFamily Allowance, Child Allowance and Infant Allowance (Annex R A 3); b)\tReimbursement of education fees: maximum amounts of reimbursement (Annex R A 4.01) for the academic year 2007/2008. Related adjustments will be applied, wherever applicable, to Paid Associates and Students. As in the past, the actual percentage increase of each salary position may vary, due to the application of a constant step value and rounding effects. Human Resources Department Tel. 73566

  10. Salary adjustments

    HR Department

    2008-01-01

    In accordance with decisions taken by the Finance Committee and Council in December 2007, salaries are adjusted with effect from 1 January 2008. Scale of basic salaries and scale of stipends paid to fellows (Annex R A 5 and R A 6 respectively): increased by 0.71% with effect from 1 January 2008. As a result of the stability of the Geneva consumer price index, following elements do not increase: a) Family Allowance, Child Allowance and Infant Allowance (Annex R A 3). b) Reimbursement of education fees: maximum amounts of reimbursement (Annex R A 4.01) for the academic year 2007/2008. Related adjustments will be implemented, wherever applicable, to Paid Associates and Students. As in the past, the actual percentage increase of each salary position may vary, due to the application of a constant step value and the rounding effects. Human Resources Department Tel. 73566

  11. Influence of different body mass index cut-off values in assessing the nutritional status of adolescents in a household survey Influência de distintos valores críticos do índice de massa corporal na avaliação do estado nutricional de adolescentes em inquérito domiciliar

    Fabio da Silva Gomes

    2009-08-01

    Full Text Available The purpose of this study was to evaluate the anthropometric nutritional status of the adolescent population of Niterói, Rio de Janeiro State, Brazil, and the influence of changes in the adopted body mass index (BMI cut-offs in the nutritional status assessment of the adolescent population. A population-based survey conducted in 2003 obtained data from a probabilistic sample of 1,734 households and 523 adolescents. The multiple proportions test and prevalence ratios were used to analyze differences between estimates obtained from different BMI cut-offs. Changes in cut-off values from the old to the new recommendation of the World Health Organization (WHO resulted in a significant increase in overweight prevalence among total, male and female adolescent population (25%, 27% and 23%, respectively (p Este artigo tem por objetivo avaliar o estado nutricional antropométrico da população adolescente residente em Niterói, Rio de Janeiro, Brasil, bem como a influência das mudanças nos valores críticos de índice de massa corporal (IMC na avaliação do estado nutricional dessa população. Uma pesquisa amostral probabilística de base populacional conduzida em 2003 obteve dados de 1.734 domicílios e 523 adolescentes. Testes para múltiplas proporções e razões de prevalência foram utilizados para analisar as diferenças entre estimativas obtidas segundo distintos valores críticos de IMC. Mudanças nos pontos de corte da antiga para a atual recomendação da Organização Mundial da Saúde (OMS resultaram em aumentos significativos nas prevalências de sobrepeso entre o total de adolescentes, meninos e meninas (25%, 27% e 23%, respectivamente (p < 0,05. A proposta da International Obesity Task Force resultou em uma redução significativa de 29% e 39% na prevalência de baixo-IMC-para-idade entre o total de adolescentes e meninos, respectivamente, quando comparada à recomendação atual da OMS (p < 0,05. Foi evidenciado que uma simples

  12. Research Progress on the Relationship of Coronary Heart Disease and D-dimer,Lipoprotein(a),Fibrinogen%D-二聚体、脂蛋白(a)、纤维蛋白原和冠心病关系研究进展

    龚小鹏

    2012-01-01

    冠心病(CHD)与D-二聚体、脂蛋白(a)、纤维蛋白原(FG)有着密切的关联,CHD患者中D-二聚体、脂蛋白(a)、FG较高,但它们之间相互作用的机制仍不明确.近年来的研究显示,D-二聚体、脂蛋白(a)和FG可能参与CHD的发病过程,因此通过测定D-二聚体、脂蛋白(a)和FG在不同危险程度的CHD患者中的含量,评估它们对于CHD的发生、发展具有重要意义.%Coronary heart disease( CHD)is closely associated with D-dimer,lipoprotein( a)and fibrino-gen( FG),CHD patients have higher levels of D-dimer,lipoprotein( a),fibrinogen while the mechanism of the interaction between them remains unclear. In recent years, studies have shown that D-dimer,lipoprotein ( a )and fibrinogen may be involved in the pathogenesis of coronary heart disease, so by measuring D-dimer, lipoprotein( a )and fibrinogen level in patients with coronary heart disease is of great significance for assessing the genesis and development of CHD.

  13. Clinical study on lysophospholipids acid, D_dimers detection in the prediction of progress and application effect of cerebral apoplexy%溶血磷脂酸、D-二聚体检测预测进展性脑卒中的临床应用研究

    胡红晓

    2014-01-01

    Objective:To study the lysophospholipids acid , D_dimers detection in the prediction of progress and application effect of cerebral apoplexy .Methods:Our hospital in April 2012 to April 2013 were 35 patients with progressive stroke ( research group ) , physical examination, 35 cases (control group) as the research object, research on two groups of objects of D -dimer, lysophosphatide acid level testing and comparison .Results:The group D -dimer level of patients >75 mu g/L, positive;Control the research object of D -dimer level <75 mu g/L, negative;Group patients were lysophospholipids , D -dimer acid average levels were significantly higher than that of control group, P <0.05).Conclusion:D -dimer, lysophosphatide acid was an important molecular markers of early thrombosis in vivo, by detecting D -dimer, lysophosphatide acid levels , could provide effective basis for clinical prediction progress sex stroke .%目的:探讨溶血磷脂酸、D-二聚体检测在预测进展性脑卒中的应用效果。方法:选取我院在2012年4月~2013年4月收治的进展性脑卒中患者35例(研究组)、健康体检者35例(对照组)作为研究对象,对2组研究对象的D-二聚体、溶血磷脂酸水平进行检测、比较。结果:研究组患者的D-二聚体水平均>75μg/L,呈阳性;对照组研究对象的D-二聚体水平均<75μg/L,呈阴性;研究组患者的溶血磷脂酸、D-二聚体平均水平均显著高于对照组,P<0.05。结论:D-二聚体、溶血磷脂酸是体内早期血栓形成的重要分子标志物,通过检测D-二聚体、溶血磷脂酸水平,可为临床预测进展性脑卒中提供有效依据。

  14. Determination and Application of the cut-off values of RBC Indexes in Screening for Silent α-Thalassemias Carriers%静止型α-地中海贫血红细胞指标临界值的确定及其应用

    汪伟山; 周玉球; 张永良; 肖奇志

    2011-01-01

    Objective To investigate the cut-off values of RBC indexes in screening silent alpha-thalassemias carriers and to evaluate clinical application of the cut-off values. Methods RBC indexes of 77 cases with silent α-thalassaemia and 151 healthy adults (as normal control group)were retrospected,β-thalassaemias and iron deficiency were excluded in the above mentioned individuals.The receiver operating characteristic(ROC)curve was used for identifying the useful RBC index and determining the cut-off values in the screening for silent α-thalassaemias. Results (1)The area under ROC curve of MCV、MCH、MCHC were 0. 857、0. 858 and 0. 740, respectively. Those indexes were of value to screen for silent α-thalassaemias carriers; (2)The cut-off values of MCV、 MC H、MCHC were 82.0 fl and 28.0pg as well as 341.5 g/L; (3)The sensitivity and specificity of the parallel test of either MCV or MCH were 93. 5 % and 72.8 %, respectively. Five silent α-thalassemia carriers failed to detect by the parallel test, resulting in a rate of 6.49%(5/77) for failure of detection, the risk of failure of detection was decreased 12 times when compared with recommended standard by TIF. They were much better than other tests. Conclusion The parallel test of either MCV≤82.0 fl or MCH≤28.0 pg can screen silent α-thalassaemia carriers effectively. The results provide the scientific basis of clinical value for clinics performing genetic counseling in the high prevalent area of thalassaemia,especially in the areas where thalassaemias can not be genotyped.%目的 探讨并评估红细胞相关指标及其临界值用于筛查静止型α-地中海贫血(α-地贫)的临床价值.方法 以77例单纯性静止型α-地贫患者和151例健康成人为研究对象,采用受试者工作特征曲线(ROC曲线)确定静止型α-地贫筛查指标及其临界值.结果 MCV、MCH、MCHC的 ROC曲线下面积分别为0.857,0.858,0.740,均有筛查价值,其最佳临界值分别为82.0 fl、28

  15. Rendimento da pupunheira em função da densidade de plantio, diâmetro de corte e manejo dos perfilhos no Vale do São Francisco Effect of density, cut-off diameter classes and shoot number on production and yield of irrigated plant peach palm at San Francisco River Valley

    José Egidio Flori

    2004-02-01

    Full Text Available Com o objetivo de avaliar o rendimento de palmito de pupunheira irrigada em função da densidade de plantio, diâmetro de corte do estipe e o manejo dos perfilhos, instalou-se um experimento na Estação Experimental de Bebedouro da Embrapa Semi-Árido, Petrolina, PE. O delineamento utilizado foi de blocos ao acaso em parcelas subdivididas, sendo as parcelas constituídas por dois espaçamentos (2,0 x 1,0 m - E1 e 2,0 x 2,0 m - E2 e as subparcelas em arranjo fatorial 2 x 2, compreendendo dois manejos de perfilhos e duas classes de diâmetros de corte. As colheitas foram feitas a partir de 16 meses até os 69 meses após o plantio e realizadas com intervalos consecutivos de mais ou menos três meses. Pelos resultados, evidenciaram-se efeitos significativos para espaçamento, manejo de perfilhos e classe de diâmetro de corte. Não foram constatadas interações entre os tratamentos. Houve efeito significativo de espaçamento sobre o rendimento, diâmetro de corte, comprimento e peso médio do palmito. O rendimento e o peso do palmito da pupunheira foram de 545 e 434 kg ha-1 ano-1 e 147 g e 180 g nos espaçamentos E1 e E2, respectivamente. O diâmetro de corte afetou a altura da planta e peso médio do palmito. O manejo de perfilho afetou o rendimento e o peso médio do palmito, com 532 e 446 kg ha-1 e 177 e 149 g de palmito, respectivamente, no manejo de quatro e todos os perfilhos por planta. Pelos resultados, infere-se, como orientação técnica para os produtores de áreas irrigadas do Submédio São Francisco, o cultivo da pupunha no espaçamento de 2 m x 1 m, o manejo de quatro perfilhos por planta e o corte da planta com diâmetro variando de 10 a 12 cm, a 30 cm do nível do solo.The objective of this experiment was to evaluate the effect of planting density, cut-off diameter classes and shoot number on heart of palm production on irrigated peach palm. The experimental layout was a randomized split-plot design with a factorial arrangement

  16. The cut-off value of waist-to-height ratio in detecting central obesity in Chinese adult population%中国成人中心性肥胖腰围身高比值的适宜切点的研究

    赵连成; 李莹; 彭亚光; 张林峰; 郭敏; 武阳丰

    2012-01-01

    目的 探讨我国中年人群腰围身高比值(WHtR)诊断中心性肥胖的适宜切点.方法 选用国家“八五”和“九五”攻关课题的两次横断面调查,共30 630名35~59岁人群资料,比较不同WHtR切点对高血压、空腹血糖异常、血清总胆固醇升高(高TC)、血清高密度脂蛋白胆固醇降低(低HDL-C)以及危险因素聚集(危险因素个数≥2)的检出效果,并分析各危险因素及其聚集的人群归因危险度.结果 预测4种危险因素的WHtR最佳切点范围在0.48~0.52,预测危险因素聚集的WHtR最佳切点在男性、女性及男女合并人群中分别为0.49、0.50及0.49.人群WHtR控制在0.50以下,叮防止人群中约2/5的高血压,1/5空腹血糖异常和高TC,1/3的低HDL-C,以及约一半的危险因素聚集.结论 WHtR为0.50可作为我国中年人群中心性肥胖评价的适宜切点.以“腰围不超过身高一半”作为体重控制理念,促进心血管病的预防.%Objective To explore the optimal cut-off value of waist-to-height ratio (WHtR) in detecting the central obesity in Chinese adult population. Methods A total of 30630 participants aged 35-59 from different areas in mainland China were surveyed for cardiovascular diseases risk factors in two independent cross-sectional studies that carried out in 1992-1994 and 1998, respectively. The sensitivity, specificity, positive and negative predictive value and Youden's index for hypertension, abnormal glucose, high serum total cholesterol (high TO, low serum high density lipoprotein cholesterol (low HDL-C) and clustering of risk factors ( number≥ 2 ) were calculated to evaluate the efficacy of detecting central obesity. The population attributable risk proportion was also used to analyze the public health signification of the optimal cut-off value. Results The optimal cut-off values of WHtR for 4 risk factors (hypertension, abnormal glucose, high TC, low HDL-C) ranged from 0.48 - 0.52. Moreover, the optimal values

  17. D-Dimer plasma levels in patients with coronary artery disease Níveis plasmáticos de Dímero D em pacientes com doença arterial coronariana

    Luciana M. Lima

    2006-12-01

    Full Text Available We have previously reported that prothrombin fragment 1+2 levels were not associated to the presence or severity of coronary artery disease (CAD and do not provide further information on subjects with CAD diagnosed by angiography. Thus, in the present study another marker of hypercoagulability was evaluated in the same subjects. This study aimed at determining D-Dimer plasma levels in a group of subjects undergoing coronary angiography to establish a likely relation between this parameter and the severity of CAD. D-Dimer plasma levels were determined in 17 subjects with no coronary atheromatosis (controls, 12 subjects with mild/moderate atheromatosis and 28 subjects with severe atheromatosis. No significant differences were observed among the three groups. Data analysis enables an inference on a tendency towards an increase in fibrinolytic activity in patients with atheromatosis, reflected by the increase in D-Dimer concentrations in the severe atheromatosis group in subjects with CAD diagnosed by coronary angiography.Em estudo prévio, os níveis plasmáticos do fragmento 1+2 da protrombina não foram associados com a presença ou com a gravidade da doença arterial coronariana (DAC, não trazendo benefício adicional pelo menos em indivíduos com diagnóstico de DAC estabelecido por angiografia. Desta forma, neste estudo outro marcador de hipercoagulabilidade foi avaliado nos mesmos pacientes. O presente estudo teve como objetivo determinar os níveis plasmáticos do dímero D de um grupo de indivíduos submetidos à angiografia coronariana, buscando estabelecer a possível correlação entre este parâmetro e a gravidade da DAC. Os níveis plasmáticos do dímero D foram determinados em amostras de sangue de 17 indivíduos com ausência de ateromatose nas coronárias (controles, 12 indivíduos apresentando ateromatose leve/moderada e 28 indivíduos apresentando ateromatose grave. Não foram encontradas diferenças estatisticamente

  18. Duplex ultrasound, clinical score, thrombotic risk, and D-dimer testing for evidence based diagnosis and management of deep vein thrombosis and alternative diagnoses in the primary care setting and outpatient ward.

    Michiels, J J; Moosdorff, W; Maasland, H; Michiels, J M; Lao, M U; Neumann, H A; Dulicek, P; Stvrtinova, V; Barth, J; Palareti, G

    2014-02-01

    Deep vein thrombosis (DVT) has an annual incidence of 0.2% in the urban population. First episodes of calf vein thrombosis (CVT) and proximal DVT are frequently elicited by risk factors, including varicose veins, cancer, pregnancy/postpartum, oral contraceptives below the age of 50 years, immobility or surgery. Leg pain and tenderness in the calf and popliteal fossa on physical examination may result from other conditions than DVT labeled as alternative diagnosis (AD) Congenital venous thrombophilia is present in every third first DVT, increased FVIII in every fourth first DVT, and FV Leiden/FII mutation in 40% of women on oral anticonceptive pill before reaching the menopause. Routine thrombophilia testing for FV Leiden/prothrombin mutation and FVIII as main risk factor for venous thrombosis is recommended. Primary superficial venous thrombosis (SVT) and DVT patients with a autosomal dominant family history of DVT are candidates for thrombophilia testing for congenital AT, PC and PS deficiency. The requirement for a safe diagnostic strategy of CVT and DVT should be based on an objective post-test incidence of venous thromboembolism (VTE) of less than 0.1% with a negative predictive value for exclusion of DVT of 99.9% during 3 months follow-up. Modification of the Wells score by elimination of the "minus 2 points" for AD is mandatory and will improve the diagnostic accuracy of CVT/DVT suspicion in the primary care setting and outpatient ward. The sequential use of complete DUS, ELISA D-dimer testing and modified clinical Wells' score assessment is safe and effective for the exclusion and diagnosis of CVT, DVT and AD. About 10% to 20% of patients with DVT develop overt post-thrombotic syndrome (PTS) at one year post-DVT, and both PTS and DVT recurrences further increase to about 30% during long-term follow-up. Objective risk stratification of PTS complications using DUS for recanalization and reflux and D-dimer testing will become an integral part in routine

  19. Approaches for predicting long-term sickness absence. Re: Schouten et al. "Screening manual and office workers for risk of long-term sickness absence: cut-off points for the Work Ability Index".

    van Amelsvoort, Ludovic Gpm; Jansen, Nicole W H; Kant, I Jmert

    2015-05-01

    an overestimation of the predictive value. A methodological approach of related issues is provided in the works of Glymour et al (5) and Hamilton et al (6). This phenomenon is even more clearly illustrated by the predictive properties of the workability index, as described by Alavinia et al (7, page 328), which reported that "when adjusted for individual characteristics, lifestyle factors, and work characteristics, two dimensions of the WAI were significant predictors for both moderate and long durations of sickness absence: (i) the presence of sickness absence in the past 12 months prior to the medical examination and (ii) experienced limitations due to health problems." So, when applied to the study by Schouten et al (1), this means that most of the predictive value would be related to the factors "sickness absence in the past 12 months". In addition, we object to the use of the term "screening" in the Schouten et al study as it includes workers with the intended outcome (long-term sickness absence). One can identify three separate aims to study the longitudinal association between risk factors and subsequent long-term sickness absence: (i) to establish causal risk factors for long-term sickness absence, often to find clues for primary preventive strategies (beyond the scope here); (ii) to identify high-risk workers who are still at work and might benefit from an intervention before sickness absence occurs (secondary prevention); and (iii) to identify workers on sick leave who might suffer a below-average return-to-work rate or have a high risk for the recurrence of (long-term) sickness absence and might benefit from intensification or optimization of the return-to-work process (tertiary prevention). In this light, one needs to separate screening instruments from predictive instruments and reserve the term "screening" for the situation as defined by Wilson and Junger (8, page 7): "The object of screening for disease is to discover those among the apparently well

  20. Imaging of deep venous thrombosis in patients using a radiolabelled anti-D-dimer Fab' fragment ({sup 99m}Tc-DI-DD3B6/22-80B3): results of a phase I trial

    Macfarlane, David [University of Queensland, School of Medicine, Brisbane (Australia); Socrates, Angelides; Larcos, George [University of Sydney, Department of Medicine, Sydney (Australia)]|[Westmead Hospital, Department of Nuclear Medicine and Ultrasound, Westmead (Australia)]|[Westmead Hospital, Centre for Biomedical Imaging and Research, Westmead (Australia); Eisenberg, Paul [Amgen Inc, Thousand Oaks, CA (United States); Roach, Paul [University of Sydney, Department of Medicine, Sydney (Australia)]|[Royal North Shore Hospital, Nuclear Medicine, St. Leonards (Australia); Gerometta, Michael [Agen Biomedical Pty Ltd, Brisbane (Australia); Smart, Richard; Tsui, Wendy [St. George Hospital, Nuclear Medicine Department, Sydney (Australia)]|[University of New South Wales, Department of Medicine, Sydney (Australia); Scott, Andrew M. [Austin Hospital, Centre for PET, Melbourne (Australia)]|[Ludwig Institute, Melbourne (Australia)

    2009-02-15

    {sup 99m}Tc-DI-DD3B6/22-80B3 (ThromboView registered, hereafter abbreviated to {sup 99m}Tc-DI-80B3 Fab') is a radiolabelled humanised monoclonal Fab' fragment with affinity and specificity for D-dimer domains of cross-linked fibrin. Detection of thromboembolic events has been demonstrated in canine models. The study objectives were evaluation of safety and characterisation of biodistribution, immunogenicity and pharmacokinetic profile of increasing doses of {sup 99m}Tc-DI-80B3 Fab' in subjects with acute lower-limb DVT. Twenty-six patients with acute lower limb DVT were enrolled. Of these, 21 received a single intravenous dose of 0.5 mg (n = 6), 1.0 mg (n = 9) or 2 mg (n = 6) {sup 99m}Tc-DI-80B3 Fab'. Blood and urine samples and gamma camera images were collected to 24 h after administration for pharmacokinetic and dosimetry analysis. Vital signs, electrocardiography, hematological and biochemical data and human anti-human antibody (HAHA) levels were monitored for up to 30 days following administration. Patients were assigned to either planar or single photon emission computed tomographic (SPECT) imaging of the thorax at 4 h following injection. Thirty-five adverse events were reported in 15 of the 21 subjects. Those deemed possibly related to administration of {sup 99m}Tc-DI-80B3 Fab' included mild hypertension, mild elevation of LD (lactate dehydrogenase) and moderate elevation of ALT (alanine transaminase). HAHA assays remained negative. Pharmacokinetics and organ dosimetry were comparable to prior normal volunteer data. Localisation of Thromboview registered to sites of known thrombus was evident as early as 30 min post-injection. In subjects with acute DVT, {sup 99m}Tc-DI-80B3 Fab' was well tolerated with favourable characteristics for the detection of acute venous thrombosis. (orig.)

  1. Imaging of deep venous thrombosis in patients using a radiolabelled anti-D-dimer Fab' fragment (99mTc-DI-DD3B6/22-80B3): results of a phase I trial

    99mTc-DI-DD3B6/22-80B3 (ThromboView registered, hereafter abbreviated to 99mTc-DI-80B3 Fab') is a radiolabelled humanised monoclonal Fab' fragment with affinity and specificity for D-dimer domains of cross-linked fibrin. Detection of thromboembolic events has been demonstrated in canine models. The study objectives were evaluation of safety and characterisation of biodistribution, immunogenicity and pharmacokinetic profile of increasing doses of 99mTc-DI-80B3 Fab' in subjects with acute lower-limb DVT. Twenty-six patients with acute lower limb DVT were enrolled. Of these, 21 received a single intravenous dose of 0.5 mg (n = 6), 1.0 mg (n = 9) or 2 mg (n = 6) 99mTc-DI-80B3 Fab'. Blood and urine samples and gamma camera images were collected to 24 h after administration for pharmacokinetic and dosimetry analysis. Vital signs, electrocardiography, hematological and biochemical data and human anti-human antibody (HAHA) levels were monitored for up to 30 days following administration. Patients were assigned to either planar or single photon emission computed tomographic (SPECT) imaging of the thorax at 4 h following injection. Thirty-five adverse events were reported in 15 of the 21 subjects. Those deemed possibly related to administration of 99mTc-DI-80B3 Fab' included mild hypertension, mild elevation of LD (lactate dehydrogenase) and moderate elevation of ALT (alanine transaminase). HAHA assays remained negative. Pharmacokinetics and organ dosimetry were comparable to prior normal volunteer data. Localisation of Thromboview registered to sites of known thrombus was evident as early as 30 min post-injection. In subjects with acute DVT, 99mTc-DI-80B3 Fab' was well tolerated with favourable characteristics for the detection of acute venous thrombosis. (orig.)

  2. 慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义%Clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients

    刘海波

    2015-01-01

    目的:探讨慢性支气管炎合并肺炎患者血浆中D-二聚体检测的临床意义。方法慢性支气管炎急性发作合并肺炎患者64例和肺栓塞患者30例,对其D-二聚体进行快速定量测定。结果慢性支气管炎急性发作合并肺炎患者和肺栓塞患者D-二聚体差异无统计学意义(P>0.05)。结论检测D-二聚体为判断慢性支气管炎是否合并肺部感染有一定的意义,且有助于判断炎症的轻重及病情变化。%Objective To investigate clinical significance of plasma D-dimer detection in chronic bronchitis complicated with pneumonia patients.Methods There were 64 cases of chronic bronchitis acute attack complicated with pneumonia and 30 cases of pulmonary embolism. Rapid quantitative determination was made for D-dimer in all patients.Results The difference of D-dimer had no statistical significance between chronic bronchitis acute attack complicated with pneumonia patients and pulmonary embolism patients (P>0.05). Conclusion Detection of D-dimer provides certain value for judging whether chronic bronchitis is complicated with pulmonary infection. This method is also helpful to judging status of inflammation and disease.

  3. Adjustments and Depression

    Full Text Available ... to my SCI? How do I deal with depression and adjustment to my SCI? ☷ ▾ Page contents The ... the moment you are injured. Understanding adjustment and depression Adjustment to paralysis is a process of changing ...

  4. The Value of D-dimer and Fibrinogen in the Diagnosis of Coronary Artery Disease%血浆D-二聚体和纤维蛋白原检测在冠心病临床诊断中的价值

    陈高科

    2014-01-01

    Objective:To study the significance of detection of plasma D-dimer and fibrinogen in the diagnosis of coronary artery disease.Method:The level of plasma D-dimer and fibrinogen of 108 patients with different types of coronary artery diseases and 62 health people from May 2011 to Dec 2012 were detected. The results of plasma D-dimer and fibrinogen were analyzed.Result:The levels of plasma D-dimer and fibrinogen of acute myocardial infarction(AMI) patients were higher than those of healthy people,unstable angina pectoris(UAP) and stable angina pectoris(SAP) patients(P0.05).Conclusion:The detection of plasma D-dimer and fibrinogen contribute to the diagnosis and typing of coronary heart disease.%目的:研究血浆D-二聚体和纤维蛋白原检测在冠心病临床诊断中的意义。方法:对2011年5月-2012年12月在笔者所在医院就诊的108例不同类型的冠心病患者及62例正常体检者的血浆D-二聚体及纤维蛋白原水平进行检测,分析D-二聚体及纤维蛋白原检测结果在冠心病临床诊断中的意义。结果:急性心肌梗死患者的D-二聚体及纤维蛋白原水平高于正常体检者、不稳定型心绞痛患者和稳定型心绞痛组患者,差异均有统计学意义(P0.05)。结论:临床血浆D-二聚体及纤维蛋白原水平的检测有助于冠心病分型诊断。

  5. 血浆D-二聚体及纤维蛋白原在非小细胞肺癌患者围术期监测中的应用价值%Value of plasma D-dimer,fibrinogen levels monitoring in non-small cell lung cancer patients in perioperative period

    江吕泉; 高坤祥; 郑建; 陈建; 吴昊; 陈林松

    2013-01-01

    Objective Bleeding or thrombotic diseases are easily to be found in non - small cell lung cancer ( NSCLC ) patients, because the equilibrium of their coagulation system might be disturbed due to tumor burden or surgical injury. In the study, we studied the value of plasma D - dimer and fibrinogen levels monitoring in patients with non - small cell lung cancer before and after surgery. Methods The plasma D - dimer and fibrinogen levels were measured in 254 patients with non - small cell lung cancer and 52 patients with benign lung tumor, and then we followed up to record the D - dimer and fibrinogen levels change in postoperative patients. Results The plasma levels of D - dimer and fibrinogen in non - small cell lung cancer patients were found to be significantly higher than those in patients with benign lung tumor ( P < 0. 01). Significant differences in D - dimer and fibrinogen levels were found among different stages of non - small cell lung cancer ( P < 0. 01 ) , which suggested that coagulation and fibrinolysis dysfunction in patients with non - small cell lung cancer aggravated along with the progression of disease. The D - dimer and fibrinogen levels kept at a high level or rose suddenly after a transient decrease in 15 patients who had thrombotic diseases after operation. Conclusions Monitoring the plasma D - dimer and fibrinogen levels in patients with non - small cell lung cancer before and after operation helps find out those who have high risk of thrombotic diseases and preventing thrombtic disease after operation. It also helps us to strive for early prevention, early diagnosis,early treatment,nd to improve the prognosis of the patients.%目的 探讨血浆D-二聚体及纤维蛋白原(fibrinogen,FIB)在非小细胞肺癌患者手术前、后监测中的应用价值.方法 测定254例非小细胞肺癌患者和52例肺部良性肿瘤患者血浆D-二聚体及FIB水平,对其术后D-二聚体及FIB变化进行随访监测.结果 非小细胞肺癌组

  6. Correlative Analysis of the Relationships and Differences on D-dimer, Fibrinogen and Antithrombin Ⅲ Between Varied Clinical Periods of Cerebral Infarction%D-D、Fb和AT-Ⅲ在脑梗死不同时期的变化及相关性分析

    徐威香; 武蓉珍; 胡晓蕾

    2012-01-01

    目的:探讨血浆D-二聚体(D-D)、纤维蛋白原(Fb)和抗凝血酶Ⅲ(AT-Ⅲ)在脑梗死(CI)不同时期的变化及其临床意义.方法:根据临床特征,对260例CI患者进行分组,其中CI急性期组80例、进展期组41例、非进展期组65例、康复期组74例;90例体检健康者为正常对照组.采用SYSMEX CA7000血凝仪分别检测其血浆D-D、Fb和AT-Ⅲ水平.结果:CI急性期、进展期、非进展期患者D-D、Fb含量均明显高于正常对照组(P<0.01),AT-Ⅲ低于正常对照组(P<0.01);脑梗死组中,D-D与AT-Ⅲ呈负相关(P<0.01),D-D与Fb呈正相关(P<0.01),AT-Ⅲ与Fb无相关性.结论:CI患者D-D、Fb、AT-Ⅲ变化显著,D-D升高伴随AT-Ⅲ含量降低,提示D-D、Fb、AT-Ⅲ共同参与了梗死发生发展的病理生理过程,可作为CI临床危险分级和病情监测的指标.%Objective To investigate the differences and its clinical significance of D-dimer, fibrinogen and antithrombin Ⅲ between varied clinical periods of cerebral infarction( CI). Methods 328 CI patients were rolled into the study, and they were divided into four groups due to their different clinical periods as follows: group acute period (80) , group progressing(41) , group non-pro-gressing(65) , group convalescence(74). And, 90 healthy volunteers were rolled into the normal control group. Their plasma D-dimer, fibrinogen and antithrombin HI were detected on SYSMEX CA7000 automatic coagulation analyzer. Results D-dimer and fibrinogen of CI patients in the acute, progressing and non-progressing periods were significantly higher (P <0.01) than those of healthy volunteers, while antithrombin Ⅲ of them was significantly lower (P<0.01) than that of healthy volunteers. In CI patients, D-dimer correlated negatively with antithrombin Ⅲ, while positively with fibrinogen. No significant relationship was observed between antithrombin Ⅲ and fibrinogen. ConclUSin D-dimer, fibrinogen and antithrombin Ⅲ of CI patients varied significantly

  7. Man Cuts Off Penis in Fit of Religious Fervor

    朱土英

    2002-01-01

    一位菲律宾的男子自残,用利刃割下了自己的阳物。主要原因是其妻离他而去。到首都马尼拉去做保姆(housemaid)了。他想象自己的阳物正像眼镜蛇一样逼近其他女性(his penis as a"cobra"(眼镜蛇)drawing him towardwomen),而《马太福音》曾云:If your hand or your foot causes you to sin,cut it offand throw it away.于是,此君对自己下了“毒手”。可幸的是,手术成功,割下的阳物又被接上。只是短了20%……

  8. The UV cut-off and trans-Planckian physics

    Full text: Physics at ultra high energies, far above those presently probed, is unknown. It is expected that modifications of the field equations become relevant at some point. Besides, it would be positive if field modes could get less relevant as bigger energies are at play. Many possible approaches to this subject, based either on some kind of refashioning of the laws of Physics, like String Theory and remaking of gravity, or on pure phenomenological grounds, are being now discussed. There does not seem to be a consensus in the literature concerning the possible outcome of these changes, nor in the near future. Moreover, one must find some observable effect of this new Physics. As such energies are not reached by experiments at hand, one needs to seek for results relevant at low energies. We address the possibility of introducing an Ultraviolet attenuation of the occupation of high modes by verifying its effects on inflationary perturbations and Hawking radiation. We consider the changes to be the outcome of an unknown modification of the physics at very high energies (Trans-Planckian Physics). The spectrum of inflationary perturbations is shown to be in agreement with observations, and the consequences for the Hawking radiation are being analyzed. (author)

  9. Tentative Colistin Epidemiological Cut-Off Value for Salmonella spp.

    Agersø, Yvonne; Torpdahl, Mia; Zachariasen, Camilla; Seyfarth, Anne Mette; Hammerum, Anette M.; Nielsen, Eva Møller

    2012-01-01

    The objective of this research was to determine minimal inhibitory concentration (MIC) population distributions for colistin for Salmonella on subtype level. Furthermore, we wanted to determine if differences in MIC for colistin could be explained by mutations in pmrA or pmrB encoding proteins involved in processes that influence the binding of colistin to the cell membrane. During 2008–2011, 6,583 Salmonella enterica subsp. enterica isolates of human origin and 1931 isolates of animal/meat o...

  10. Tentative Colistin Epidemiological Cut-Off Value for Salmonella spp

    Agersø, Yvonne; Torpdahl, Mia; Zachariasen, Camilla;

    2012-01-01

    The objective of this research was to determine minimal inhibitory concentration (MIC) population distributions for colistin for Salmonella on subtype level. Furthermore, we wanted to determine if differences in MIC for colistin could be explained by mutations in pmrA or pmrB encoding proteins...... involved in processes that influence the binding of colistin to the cell membrane. During 2008–2011, 6,583 Salmonella enterica subsp. enterica isolates of human origin and 1931 isolates of animal/meat origin were collected. The isolates were serotyped, and susceptibility was tested towards colistin (range...... 1–16 mg/L). Moreover, 37 isolates were tested for mutations in pmrA and pmrB by polymerase chain reaction (PCR) and DNA sequencing. MIC distribution for colistin at serotype level showed that Salmonella Dublin (n=198) followed by Salmonella Enteritidis (n=1247) were less susceptible than “other...

  11. A cut-off tubular geometry of loop space

    Mukhopadhyay, Partha

    2014-01-01

    Motivated by the computation of loop space quantum mechanics as indicated in [7], here we seek a better understanding of the tubular geometry of loop space ${\\cal L}{\\cal M}$ corresponding to a Riemannian manifold ${\\cal M}$ around the submanifold of vanishing loops. Our approach is to first compute the tubular metric of $({\\cal M}^{2N+1})_{C}$ around the diagonal submanifold, where $({\\cal M}^N)_{C}$ is the Cartesian product of $N$ copies of ${\\cal M}$ with a cyclic ordering. This gives an infinite sequence of tubular metrics such that the one relevant to ${\\cal L}{\\cal M}$ can be obtained by taking the limit $N\\to \\infty$. Such metrics are computed by adopting an indirect method where the general tubular expansion theorem of [12] is crucially used. We discuss how the complete reparametrization isometry of loop space arises in the large-$N$ limit and verify that the corresponding Killing equation is satisfied to all orders in tubular expansion. These tubular metrics can alternatively be interpreted as some n...

  12. 联检NSE、CYFRA21-1、D-二聚体、Fib在肺癌患者中的临床意义%Clinical significance of the combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen for the patients with lung cancer

    谢颖; 贾张军; 张云生

    2014-01-01

    Objective To discuss the clinical significance of the combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen for lung cancer patients. Methods The levels of serum NSE and CYFRA21-1 were detected by electrochemical analysis in 256 lung cancer patients, 200 patients with benign lung diseases and 200 health subjects. The levels of plasma D-Dimer and Fibrinogen were detected by immunoturbidimetric assays. The relationship of NSE, CYFRA21-1, D-Dimer and Fibrinogen levels with the clinical stages of lung cancer was analyzed by statistics. Results The levels of NSE, CYFRA21-1, D-Dimer and Fibrinogen in patients with lung cancer were significantly higher than those in patients with benign lung diseases and healthy controls(PCYFRA21-1 > D-Dimer > Fibrinogen.CYFRA21-1 showed the highest sensitivity(69.0%) in squamous cellcarcinoma, and NSE showed the highest sensitivity(68.4%%) in smal celllung cancer. The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen might significantly improve the sensitivity for the diagnosis of lung cancer. The combined determination of NSE,CYFRA21-1, D-Dimer, Fibrinogen showed the highest sensitivity(89.8%).NSE,CYFRA21-1, D-Dimer, Fibrinogen were positively related to the clinical stages of lung cancer. With the increasing of clinical stages, the levels of NSE,CYFRA21-1, D-Dimer, Fibrinogen in Ⅲ/Ⅳ stage were significantly higher than those in Ⅰ/Ⅱ stage(correlation coefficie nt(r)=0.315,0.425,0.669,0.523,). Conclusions The combined determination of NSE, CYFRA21-1, D-Dimer, Fibrinogen has an important clinical significance in the clinical diagnosis, differentiation, monitor and clinical stage of lung cancer.%联合检测神经元特异烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)、D-二聚体(D-D)、Fib(纤维蛋白原),探讨其在肺癌患者中的临床意义。方法肺癌组(256例)、肺良性疾病组(200例)和正常对照组(200例)的血清NSE、CYFRA21-1水平采用电化学发光分析法检测,血

  13. Clinical significance in squamous cell lung cancer patients with serum CYFRA21-1 and SCC by ROC curve and cut-off theory%肺鳞癌患者血清CYFRA21-1和SCC检测及ROC曲线和截断点的理论分析

    刘磊; 刘彬; 朱莉莉; 张薇

    2012-01-01

    目的:探讨血清细胞角蛋白19片段(CYFRA21-1)抗原和鳞癌抗原(SCC)对肺鳞癌的临床意义.方法:将研究对象分组,试验组为102例肺鳞癌患者,对照组为53例良性肺病患者.分别采用电化学发光法和酶联免疫法检测血清CYFRA21-1及SCC,测定值用t检验,率比较用x2检验.接受者工作特征(ROC)曲线及截断点选择理论评估CYFRA21-1及SCC的临床价值.结果:肺鳞癌组与良性肺病组CYFRA21-1和SCC水平差异有统计学意义;CYFRA21-1以3.3 ng/mL、SCC以1.5 ng/mL为诊断临界点,CYFRA21-1诊断肺鳞癌敏感性为57.84%,特异性为92.45%,准确性为69.68%,ROC曲线下面积为0.788;SCC诊断肺鳞癌敏感性为33.33%,特异性为92.45%,准确性为53.55%,ROC曲线下面积为0.691;CYFRA21-1诊断肺鳞癌最佳截断点为2.485或2.365 ng/mL,对应敏感性和特异性分别为65.7%、92.5%和67.6%、90.6%;SCC诊断肺鳞癌最佳截断点为0.55 ng/mL,对应敏感性和特异性分别为72.5%和62.3%.随肺鳞癌分期增高,CYFRA21-1和SCC浓度增高差异有统计学意义,CYFRA21-1敏感性增高差异有统计学意义,SCC敏感性无明显变化.结论:CYFRA21-1对肺鳞癌的诊断具有较高的临床价值,而SCC对肺鳞癌的诊断价值较低.%OBJECTIVE: To make further efforts and investigate the clinical significance of cytokeratin fragment 19 (CYFRA21-l)and squamous cell carcinoma antigen(SCC) of serum tumor markers (TM) in the diagnosis of squamous cell lung cancer patients. METHODS: The subjects were divided into two groups: the squamous cell lung cancer group (102 patients) and the benign lung disease group(53 patients). The electric chemisty irradiance was used to examine blood serum CYFRA21-1 and SCC was examined by ELISA. The results were examined by z-test, and the rate comparison were examined by Chi-square test. Receiver operator characteristic curve and cut-off choice theory were used to value the results. RESULTS: Significant

  14. Clinical significance on changes of platelet aggregation test, von Willebrand factor,antithrombin and D-dimer assayin acute cerebral infarction patients%急性脑梗死患者血小板聚集功能、血管性血友病因子、抗凝血酶及 D-二聚体测定的临床意义

    叶青跃; 程鹏飞; 周有利; 饶汉武; 黄承芳; 周立

    2015-01-01

    目的:探讨急性脑梗死患者血小板聚集功能( PAgT)、血管性血友病因子( vWF)、抗凝血酶( AT)和D-二聚体( D-dimer)水平变化及临床意义。方法选用相应的方法和仪器测定112例脑梗死及80例健康对照者血(浆) PAgT、vWF、AT和D-dimer水平变化,同时对部分患者进行治疗前、后的对比分析。结果脑梗死患者血中PAgT、vWF、D-dimer等指标均明显高于健康对照组,AT活性较对照组显著降低,差异有统计学意义(P<0.05或P<0.01)。选取经治疗效果明显好转的78例脑梗死患者,出院前取空腹静脉血测定PAgT、vWF、AT、D-dimer等指标,并与治疗前对照,结果治疗后PAgT、vWF、D-dimer降低,AT活性升高,差异有统计学意义(P<0.05或P<0.01)。结论脑梗死患者体内存在明显的凝血及纤溶功能异常,与血管内皮损伤、血小板聚集功能增强、凝血及纤溶功能亢进、抗凝功能降低等多因素有关。 PAgT、vWF、AT、D-dimer可以作为脑梗死患者诊断、治疗监测和预后判断的参考指标。%Objective To evaluate the clinical signification of coagulation ,anti-coagulation and fibrinolysis indexes i.e.platelet aggrega-tion test(PAgT),von Willebrand factor(vWF),antithrombin(AT),D-dimer in acute cerebral infarction patients.Methods vWF was as-sayed using ELISA method,AT was determined by chromogenic substances assay,and Latex enhanced immune turbidimetry for D-dimer. vWF,AT and D-dimer all the parameters were finished by SysmexCA-7000 automated blood coagulation analyzer.PAgT was measured sim-ultaneously using a whole-blood Lumi-Aggregometer by CHRMNO-LOG platelet aggregation apparatus.Results PAgT, vWF, D-dimer were significantly higher in acute cerebral infarction patients group,compared with those in the control group(P<0.05 or P<0.01). while AT was significantly lower(P<0.05).After effective treatment,PAgT,vWF,AT,D-dimer Indicators are all

  15. Clinical diagnostic value of serum ferritin united with plasma D-Dimer test in patients with cerebral infarction%血清铁蛋白联合D-二聚体检测对脑梗死患者的诊断价值

    陈勇坚

    2011-01-01

    Objective: To investigate the clinical significance of serum ferritin and plasma D-dimer in diagnosing cerebral infarction. Methods: To select 215 cases of cerebral infarction patients in our hospital from 2008 to 2010 as treatment group, 215 cases of normal people as control group, and to compare serum ferritin and D-dimer in two groups. Then compare serum ferritin and D-dimer results of live cerebral infarction patients before and after urokinase thrombolysis therapy.Results: 6 cases died during the therapy among the 215 patients, 1 patients died of cerebral hernia, 3 cases died of lung infection, 2 cases died of cerebral infarction with myocardial infarction. The differences of D-dimer between the two groups had statistical significance (t=7.325, P<0.01). There were significant differences between the normal and patients in serum ferritin as well (t=7.923, P<0.01). And D-dimer of live cerebral infarction patients increase obviously after thrombolysis therapy (t=8.301, P<0.01), the serum ferritin decreased obviously (t=9.627, P<0.01). Conclusion: The test results of serum ferritin and D-dimer are sensitive to diagnose cerebral infarction, and closely related with the recovery and prognosis.%目的:研究脑梗死患者血清内D-二聚体和铁蛋白含量对脑梗死诊断的意义.方法:选择我院2008~2010年脑梗死患者215例为治疗组,正常门诊体检者215例为对照组,行血清内D-二聚体和铁蛋白检测比较,尿激酶溶栓后再次检测存活的209例脑梗死患者溶栓前后体内D-二聚体和铁蛋白含量.结果:治疗组中,有6例在研究过程中死亡,1例死于脑疝,3例死于肺部感染,2例死于脑梗死合并下壁心肌梗死.正常人与脑梗死患者D-二聚体含量比较差异具有高度统计学意义(t=7.325,P<0.01);正常人与脑梗死患者血清含铁蛋白比较,差异有高度统计学意义(t=7.923,P<0.01).尿激酶溶栓后,治疗组所有存活病例的血清D-二聚

  16. Adjustments and Depression

    Full Text Available ... adjustment and depression Adjustment to paralysis is a process of changing one's thoughts and feelings and is ... stem cell research? What is the clinical trials process? Get support Ask us anything Get a peer ...

  17. Adjustments and Depression

    Full Text Available ... depression and adjustment to my SCI? How do I deal with depression and adjustment to my SCI? ☷ ▾ ... following an SCI? What are the secondary conditions? I have no health insurance, what are my options? ...

  18. Annual Adjustment Factors

    Department of Housing and Urban Development — The Department of Housing and Urban Development establishes the rent adjustment factors - called Annual Adjustment Factors (AAFs) - on the basis of Consumer Price...

  19. Adjustments and Depression

    Full Text Available ... course an adjustment period as you navigate your new normal. The most important point to remember is ... to rebuild one's identity and to find a new balance in relationships. The stages of adjustment can ...

  20. Avaliação do dímero D (D-Di na doença hipertensiva específica da gravidez (DHEG D-dimer plasma levels assessment in preeclampsia

    Luci Maria Sant'Ana Dusse

    2003-09-01

    Full Text Available A doença hipertensiva específica da gravidez (DHEG, na sua forma pura, caracteriza-se pelo aparecimento, em grávida normotensa, após a vigésima semana de gestação, da tríade sintomática: hipertensão, proteinúria e edema. A DHEG está associada a vasoconstrição generalizada, anormalidades da coagulação e deposição de fibrina na microcirculação da placenta. A fibrina compromete a perfusão adequada da placenta, contribuindo para a prematuridade, o baixo peso fetal e a mortalidade neonatal. Os dímeros D (D-Di constituem os menores fragmentos dos produtos de degradação da fibrina (pdf e são produzidos após a lise, pela plasmina, da ligação cruzada da fibrina. Níveis plasmáticos aumentados de D-Di indicam tanto uma exacerbação da formação de fibrina como um aumento da ação da plasmina. O presente trabalho teve por objetivo avaliar e comparar os níveis plasmáticos de D-Di, obtido por Elisa (Stago em gestantes-controle (n = 26, gestantes com DHEG nas formas leve e moderada (n = 23 e gestantes com DHEG na forma grave (n = 20, visando a investigar a possível utilização desse marcador laboratorial para diagnóstico e/ou prognóstico da doença. As médias e os desvios padrões obtidos para os três grupos avaliados foram 1.146,6 ± 311,2; 1.060,3 ± 259,2 e 1.497,8 ± 435,3ng/ml, respectivamente. A análise estatística das médias dos resultados obtidos revelou um aumento significativo de D-Di plasmático no grupo com DHEG grave, comparando-se aos grupos com DHEG leve/moderada (p Preeclampsia is associated to a generalized vasoconstriction, clot abnormalities and fibrin deposition within placenta microcirculation. The presence of fibrin hampers the placenta perfusion contributing to prematurity, fetal low weight and neonates' mortality. D-Dimers (D-Di are the products of degradation of cross-linked fibrin by plasmin. Increased plasma levels of D-Di may indicate either an exacerbated fibrin formation or an increase

  1. 降钙素原与D-二聚体在评估急诊脓毒症患者病情及预后的研究%Clinical significance of procalcitonin and D-dimer in evaluation of condition and prognosis of sepsis patients in emergency department

    张娙; 董静莲; 王书亮

    2015-01-01

    OBJECTIVE To define the value of procalcitonin and D-dimer in the evaluation of illness condition of the sepsis patients in emergency department and in the predication of prognosis so as to provide guidance for clinical treatment of the sepsis patients.METHODS By means of prospective case-control survey,the concentrations of procalcitonin and D-dimer were determined within 24 hours after the patients were confirmed as the sepsis,the A-PACHEⅡ scoring was performed,the relationship between the D-dimer combined with procalcitonin and the se-verity of sepsis was observed,the patients were divided into the survival group and the death group on the basis of observation endpoint,which was set by the clinical death or survival;the ROC cure was employed to analyze the ability of D-dimer combined with procalcitonin in prediction of the prognosis of the sepsis patients.RESULTS The severer the illness condition of the sepsis patients,the higher the contents of procalcitonin and D-dimer were (P<0.05);the concentration of the procalcitonin and D-dimer of the death group was significantly higher than that of the survival group (P<0.05).With the death set as the final cutoff point,the areas under the ROC curve in predi-cating the mortality of the sepsis patients by procalcitonin and D-dimer were 0.779 and 0.730,respectively.The sensitivity and specificity of procalcitonin in predication of adverse prognosis were respectively 78.6% and 72.7%when the concentration was 7.1 ng/ml;the sensitivity and specificity of D-dimer in predication of adverse progno-sis of the sepsis patients were respectively 78.6% and 65.5% when the concentration was 2.75 mg/L. CONCLUSION Procalcitonin and D-dimer can not only effectively assess the illness condition of the sepsis patients but also predict the prognosis of the patients.%目的:明确降钙素原及D-二聚体在评估急诊脓毒症患者病情以及预测患者预后的能力,以期掌握脓毒症患者病情并指导临床工作。方

  2. Prognostic values of heart-type fatty acid-binding protein and D-dimer level in plasma in acute pulmonary embolism patients%心肌型脂肪酸结合蛋白联合血浆D-二聚体对肺栓塞预后评估的临床意义

    陶琳; 杨毅

    2015-01-01

    ObjectiveTo evaluate the clinical value of heart-type fatty acid-binding protein (H-FABP) and D-dimer in assessing the prognosis of acute pulmonary embolism (APE). MethodsTotaly 120 APE patients were hospitalized from January 2011 to December 2014 and enroled in this study. The plasma H-FABP and D-dimer level were measured by enzyme-linked immunosorbent assay. The APE patients were divided three groups including low-risk, middle-risk and high-risk group by European heart association new guidelines. According to the clinical prognosis, the APE patients were divided into survival and death group. The H-FABP and D-dimer level in different groups and the relationship with the prognosis were assessed.ResultsWith the increased severity in patients, the H-FABP and D-dimer level were significantly elevated (P<0.05); the H-FABP and D-dimer level were significantly higher in death group as compared with survival group (P<0.05). The H-FABP and D-dimer level were positively correlated (r=0.693,P=0.000). ROC curves analysis results showed that the area under curve of H-FABP was 0.845 (95%CI: 0.752-0.918), and optimal operating point (OOP) was 8.65 µg/L, which had 81.24% sensitivity and 84.14% specificity; ACU of D-dimer was 0.832 (95%CI: 0.728-0.899), and OOP was 1.25 mg/L, which had 83.72% sensitivity and 82.65% specificity.Conclusion The H-FABP and D-dimer can effectively assess severity and prognosis of APE patients, meanwhile, it provide an objective basis for the clinical individual treatment and reducing the mortality rate of APE patients.%目的:探讨心肌型脂肪酸结合蛋白(H-FABP )联合血浆 D-二聚体在评价急性肺栓塞(APE)患者预后中的临床价值。方法选取本院2011年1月至2014年12月确诊的APE患者120例为研究对象,采用酶联免疫吸附法分别测定外周血H-FABP及D-二聚体浓度。根据病情严重程度将APE患者分为低危组、中危组及高危组;根据临床转归,分为存活组和死亡组

  3. 儿童单纯性肥胖危险因素分析及与血浆D-二聚体的相关性%Analysis of risk factors of childhood simple obesity and its relationship with plasma D-dimer

    张晓杰; 刘静; 孙利伟; 田玉玲

    2012-01-01

    目的 探讨儿童单纯性肥胖的危险因素以及血浆D-二聚体与肥胖的相关性.方法 采用问卷调查和体格测量的方法调查2006年1月 - 2010年12月就诊的单纯性肥胖儿童530例,其中102例测定血浆D-二聚体.同时选取120例性别、年龄、地区分布相匹配的健康儿童作对照,其中89例测定血浆D-二聚体.结果 肥胖儿童出生体质量、其父母平均体质指数(BMI)均较对照组明显增高,差异有统计学意义(P均< 0.01);肥胖儿童较正常对照儿童每日运动时间少,睡眠时间和看电视时间多,差异均有统计学意义(P均< 0.01);儿童肥胖与饮食有关;肥胖儿童有心血管病家族史的比例明显高于对照组,血浆D-二聚体含量(0.85 ± 0.31)mg/L亦较对照组(0.30 ± 0.11)mg/L明显增高,差异均有统计学意义(P < 0.001).结论 儿童肥胖是遗传因素和环境因素共同作用的结果,血浆D-二聚体与儿童单纯性肥胖具有相关性.%Objective To investigate the risk factors of children simple obesity and the association of plasma D-dimer and children simple obesity. Methods The height and body weight of 530 outpatients with simple obesity were measured and questionnaire survey was processed from January 2006 to December 2010. The plasma D-dimer was tested in 102 children of them. Meanwhile, 120 healthy children were selected as control with matched gender, age and region. The plasma D-dimer was also measured. Results The birth weight and the mean parents BMI of obese children were significantly higher than those of control group (P < 0.01). Compared with the control group, obese children daily exercised less time but spent more time on sleeping and watching TV (all P < 0.01). Children obesity was diet related, and the percentage of family history of cardiovascular disease and the levels of D-dimer in obese children were significantly higher than those in control group (P < 0.001). Conclusions Obesity in children is

  4. Repatriation Adjustment: Literature Review

    Gamze Arman

    2009-12-01

    Full Text Available Expatriation is a widely studied area of research in work and organizational psychology. After expatriates accomplish their missions in host countries, they return to their countries and this process is called repatriation. Adjustment constitutes a crucial part in repatriation research. In the present literature review, research about repatriation adjustment was reviewed with the aim of defining the whole picture in this phenomenon. Present research was classified on the basis of a theoretical model of repatriation adjustment. Basic frame consisted of antecedents, adjustment, outcomes as main variables and personal characteristics/coping strategies and organizational strategies as moderating variables.

  5. Theory of adaptive adjustment

    Weihong Huang

    2000-01-01

    Full Text Available Conventional adaptive expectation as a mechanism of stabilizing an unstable economic process is reexamined through a generalization to an adaptive adjustment framework. The generic structures of equilibria that can be stabilized through an adaptive adjustment mechanism are identified. The generalization can be applied to a broad class of discrete economic processes where the variables interested can be adjusted or controlled directly by economic agents such as in cobweb dynamics, Cournot games, Oligopoly markets, tatonnement price adjustment, tariff games, population control through immigration etc.

  6. ADJUSTABLE CHIP HOLDER

    2009-01-01

    An adjustable microchip holder for holding a microchip is provided having a plurality of displaceable interconnection pads for connecting the connection holes of a microchip with one or more external devices or equipment. The adjustable microchip holder can fit different sizes of microchips with ...

  7. Predictive value of D-dimer quantitative determination on postpartum hemorrhage with hypertensive disorder in pregnancy%D-二聚体定量检测对妊娠期高血压疾病患者产后出血的预测价值

    陈佩芬; 李林娜; 陈小燕; 翁美卿; 陈伟忠; 黄桂花

    2014-01-01

    Objective To investigate the predictive value of D-dimer quantitative determination on postpartum hemorrhage with hypertensive disorders in pregnancy patients .Methods One hundred and fifty cases with hypertensive disorders in pregnancy admitted to Chaozhou Hospital from January 2013 to December 2013 were retrospectively analyzed .D-dimer data of all the 150 patients were collected at the 24 hours before delivery .The patients were divided into postpartum hemorrhage group and control group .The correlation between the D-dimer measurement and a loss of blood in the postpartum period was analyzed by one-way ANOVA, and the accuracy of D-dimer predictive variables of postpartum hemorrhage was analyzed by ROC curves .Results Twenty-eight cases had postpartum hemorrhage , and the incidence rate was 18.67% ( 28/150 ) . The average value of D-dimer was ( 9.56 ±11.97 ) mg/L in the postpartum hemorrhage group, while the average value of D-dimer was (1.96 ±1.06) mg/L in the control group, with a significant difference (F=48.61, P<0.01).The area under the ROC curve was 0.848 (95% CI:0.766-0.930), standard error was 0.042.The optimal threshold was 2.26 mg/L, whose specificity, sensitivity and Youden index were 66.4%, 92.9% and 0.593,respectively.Conclusion Quantitative determination of D-dimer has a significant role in predicting postpartum hemorrhage on hypertensive disorders in pregnancy patients , the optimal threshold is 2.26 mg/L.%目的:探讨D-二聚体定量检测对妊娠期高血压疾病患者产后出血的预测价值。方法潮州市潮州医院妇产科2013年1月至2013年12月收治150例妊娠期高血压疾病患者,对其分娩前24 h内D-二聚体进行定量测定,并准确计量其分娩24 h内出血量,依出血量将其分为产后出血组及对照组。单因素方差分析其分娩前24 h内D-二聚体测量值与分娩后24 h内出血量的相关性,以ROC曲线分析其对妊娠期高血压疾病患者产后出血的预测截

  8. Heparin and normal saline solutions for measurement of central venous pressure in elderly patients with elevated D-dimer levels%肝素生理盐水用于D-二聚体升高老年患者中心静脉测压研究

    赵陈英; 陈华; 李威

    2012-01-01

    Objective To solve the problem of catheter blockage developed after measurement of central venous pressure (CVI) in elderly patients with elevated D-dimer levels. Methods Seventy-four elderly patients with elevated D-dimer levels were divided into a control group (n = 34) and an observation group (n = 40) receiving either normal saline or 125 U/mL of heparin and normal saline solutions for CVI measurement. Results Compared with the control group, the observation group achieved less blockage of catheters, higher planned extubation, and longer indwelling time of catheters (P0. 05). Conclusion Measurement of central venous pressure in elderly patients with elevated D-dimer levels by using 125 U/mL of heparin and normal saline solutions, can reduce blockage of catheters.%目的 解决D-二聚体升高老年患者行中心静脉测压后易出现深静脉导管堵塞的问题.方法 将74例D-二聚体升高老年患者分为对照组34例、观察组40例,对照组采用生理盐水行中心静脉测压,观察组采用125 U/mL肝素生理盐水行中心静脉测压.结果 观察组堵管发生率低于对照组,计划拔管的比例高于对照组,置管时间长于对照组(均P<0.01).观察组未发生出血征象,APTT值测压前后比较,差异无统计学意义(P>0.05).结论采用125 U/mL肝素生理盐水对D-二聚体升高老年患者进行中心静脉测压,可降低测压后深静脉导管堵塞发生率,有利于静脉途径的治疗与护理.

  9. Determinação de escore e nota de corte do módulo de asma do International Study of Asthma and Allergies in Childhood para discriminação de adultos asmáticos em estudos epidemiológicos Determining the score and cut-off point that would identify asthmatic adults in epidemiological studies using the asthma module of the International Study of Asthma and Allergies in Childhood questionnaire

    Elayne de Fátima Maçãira

    2005-12-01

    Full Text Available OBJETIVO: Validar o questionário padronizado escrito do International Study of Asthma and Allergies in Childhood, módulo sobre asma, para pesquisa de prevalência de asma, estabelecendo seu escore e a nota de corte para discriminação de adultos asmáticos. MÉTODOS: Entrevistamos pacientes ambulatoriais adultos, 40 asmáticos e 38 controles, pareados por sexo e idade, utilizando o módulo de asma do International Study of Asthma and Allergies in Childhood, composto por oito aspectos dicotômicos de asma. Determinamos o escore e a nota de corte para discriminação de asmáticos, definindo sua sensibilidade, especificidade e índice de Youden. Validamos o método em contraposição ao diagnóstico clínico e funcional. A reprodutibilidade das questões individuais foi testada por meio de reentrevistas de metade dos pacientes após algumas semanas. RESULTADOS: O escore variou de 0 a 14 pontos. Um escore = 5 pontos permitiu discriminar pacientes asmáticos (sensibilidade = 93%, especificidade = 100% e índice de Youden = 0,93. A maioria das questões apresentou boa reprodutibilidade, observada em reentrevista após 48,2 ± 11,1 dias (Kappa e Kappa ponderado variando de 0,43 a 1,00 para as questões individuais. CONCLUSÃO: A validação de uma nota de corte permite uma interpretação alternativa às informações fornecidas pelo módulo de asma do International Study of Asthma and Allergies in Childhood, levando em conta o conjunto das informações e não somente as respostas individuais de cada questão em estudos de prevalência de asma em adultos.OBJECTIVE: To validate, for use in asthma prevalence studies, the asthma module of the standardized written questionnaire developed for use in the International Study of Asthma and Allergies in Childhood, establishing the score and cut-off point that would identify asthmatic adults. METHODS: We interviewed 78 adult outpatients (40 adult asthmatics and 38 age-matched and gender-matched controls

  10. Family Adjustment to Aphasia

    ... Public / Speech, Language and Swallowing / Disorders and Diseases Family Adjustment to Aphasia Richard S. was a senior manager ... It also presents a great challenge to the family. There may be tension among family members and ...

  11. Adjustments and Depression

    Full Text Available ... identity and to find a new balance in relationships. The stages of adjustment can include grieving, taking ... treatment options. Related pages What is a complete vs incomplete injury? What emergency procedures occur following an ...

  12. Adjustments and Depression

    Full Text Available ... thoughts and feelings and is something that takes time. The goal of adjusting is to rebuild one's ... updates about our impact > Get the Reeve newsletter International support > Pages in other languages Made with ♡ in ...

  13. Adjustments and Depression

    Full Text Available ... rebuild one's identity and to find a new balance in relationships. The stages of adjustment can include ... a peer mentor Advocate for change Fundraise with Team Reeve Champions Committee Volunteering About Us Our story ...

  14. 乙型肝炎后肝硬化患者凝血功能和血浆D-二聚体水平与Child-Pugh肝功能分级的关系分析%Changes in the Levels of D-dimer and CoagulationFactor in Patients with Liver Cirrhosis

    胡晓; 程超; 冯立民

    2013-01-01

    目的 了解不同临床分级的乙型肝炎后肝硬化患者凝血功能和血浆D-二聚体的变化及临床意义.方法 选取浙江大学医学院附属第一医院传染病科2012年1月~7月住院的乙型肝炎后肝硬化患者90例,所有患者按Child-Pugh肝功能分级标准相应分为Child A,Child B和Child C三级.健康对照组为同期在该院体检的87例健康成人,检测乙型肝炎后肝硬化患者组和健康体检者组的D-二聚体,PT,APTT,Fbg和TT并比较分析,同时观察这些指标与Child-Pugh肝功能分级和腹腔积液的关系.结果 90例乙型肝炎后肝硬化患者血浆D-二聚体,PT,APTT和TT显著高于健康对照组,Fbg则显著低于健康对照组,差异有统计学意义(P0.05).结论 血浆D-二聚体及常规凝血功能的检测对了解肝硬化患者有无纤溶亢进和高凝状态有着重要的意义,有利于临床指导治疗和判断预后.腹腔积液可能是肝硬化患者D-二聚体增高的重要因素.%Objective To explore the clinical significance of detecting D-dimer,prothrombin time (PT) ,actived partial throm-boplatin time(APTT) , fibrinogen(Fbg) and thrombin time(TT) in the patients with liver cirrhosis.Methods 90 cases of liver cirrhosis patients and 87 healthy persons were detected in plasma coagulation factor and the observation of these coagulation index and liver function Child-Pugh classification of the relationship.Results The plasma levels of D-dimer, PT, APTT and TT were higher and the concentration of Fbg was lower in patients with liver cirrhosis than healthy persons (P <0.01).There were significant difference among three groups of Child-Pugh classification.The plasma levels of D-dimer, prothrombin time (PT),actived partial thromboplatm time (APTT) and thrombin time(TT) had significant difference between the groups of seroperitoneum and without seroperitoneum (P<0.01).Conclusion The detection of D-dimer, PT, APTT, Fbg and TT can reflect the severity of liver cirhosis

  15. Occupational Adjustment of Immigrants

    Zorlu, Aslan

    2011-01-01

    This paper examines the speed of the occupational adjustment of immigrants using Labour Force Surveys 2004 and 2005 from Statistics Netherlands. The analysis provides new evidence that immigrants start with jobs at the lower levels of skill distribution. Their occupational achievement improves significantly with the duration of residence. The extent of this initial disadvantage and the rate of adjustment vary across immigrant groups according to the transferability of skills associated with t...

  16. KVA: Capital Valuation Adjustment

    Andrew Green; Chris Kenyon

    2014-01-01

    Credit (CVA), Debit (DVA) and Funding Valuation Adjustments (FVA) are now familiar valuation adjustments made to the value of a portfolio of derivatives to account for credit risks and funding costs. However, recent changes in the regulatory regime and the increases in regulatory capital requirements has led many banks to include the cost of capital in derivative pricing. This paper formalises the addition of cost of capital by extending the Burgard-Kjaer (2013) semi-replication approach to C...

  17. Adjusting wheal size measures to correct atopy misclassification

    Zhang H

    2011-08-01

    Full Text Available Hongmei Zhang1,*, Wilfried Karmaus1,*, Jianjun Gan2, Weichao Bao1,*, Yan D Zhao3, Dewi Rahardja3, John W Holloway5, Martha Scott4,5, Syed Hasan Arshad4,51Department of Epidemiology and Biostatistics, The University of South Carolina, Columbia, SC, USA; 2GlaxoSmithKline, Research Triangle Park, NC, USA; 3Department of Clinical Science and Simmons Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA; 4The David Hide Asthma and Allergy Research Center, St Mary’s Hospital, Newport, Isle of Wight, UK; 5School of Medicine, University of Southampton, Southampton, UK *These authors contributed equally to this articlePurpose: Skin prick testing (SPT is fundamental to the practice of clinical allergy identifying relevant allergens and predicting the clinical expression of disease. Wheal sizes on SPT are used to identify atopic cases, and the cut-off value for a positive test is commonly set at 3 mm. However, the measured wheal sizes do not solely reflect the magnitude of skin reaction to allergens, but also skin reactivity (reflected in the size of histamine reaction and other random or non-random factors. We sought to estimate wheal sizes exclusively due to skin response to allergens and propose gender-specific cutoff points of atopy.Methods: We developed a Bayesian method to adjust observed wheal sizes by excluding histamine and other factor effects, based on which revised cutoff points are proposed for males and females, respectively. The method is then applied to and intensively evaluated using a study population aged 18, at a location on the Isle of Wight in the United Kingdom. To evaluate the proposed approach, two sample t-tests for population means and proportion tests are applied.Results: Four common aeroallergens, house dust mite (HDM, grass pollen, dog dander, and alternaria are considered in the study. Based on 3 mm cutoff, males tend to be more atopic than females (P-values are between 0.00087 and 0.062. After applying the

  18. Use of a Sampling Area-Adjusted Adenosine Triphosphate Bioluminescence Assay Based on Digital Image Quantification to Assess the Cleanliness of Hospital Surfaces.

    Ho, Yu-Huai; Wang, Lih-Shinn; Jiang, Hui-Li; Chang, Chih-Hui; Hsieh, Chia-Jung; Chang, Dan-Chi; Tu, Hsin-Yu; Chiu, Tan-Yun; Chao, Huei-Jen; Tseng, Chun-Chieh

    2016-01-01

    Contaminated surfaces play an important role in the transmission of pathogens. We sought to establish a criterion that could indicate "cleanliness" using a sampling area-adjusted adenosine triphosphate (ATP) assay. In the first phase of the study, target surfaces were selected for swab sampling before and after daily cleaning; then, an aerobic colony count (ACC) plate assay of bacteria and antibiotic-resistant bacteria was conducted. ATP swabs were also tested, and the ATP readings were reported as relative light units (RLUs). The results of the ACC and ATP assays were adjusted according to the sampling area. During the second phase of the study, a new cleaning process employing sodium dichloroisocyanurate (NaDCC) was implemented for comparison. Using the criterion of 2.5 colony-forming units (CFU)/cm², 45% of the sampled sites were successfully cleaned during phase one of the study. During phase two, the pass rates of the surface samples (64%) were significantly improved, except under stringent (5 RLU/cm²) and lax (500 RLU) ATP criteria. Using receiver-operating characteristic curve analysis, the best cut-off point for an area-adjusted ATP level was 7.34 RLU/cm², which corresponded to culture-assay levels of <2.5 CFU/cm². An area adjustment of the ATP assay improved the degree of correlation with the ACC-assay results from weak to moderate. PMID:27294944

  19. Use of a Sampling Area-Adjusted Adenosine Triphosphate Bioluminescence Assay Based on Digital Image Quantification to Assess the Cleanliness of Hospital Surfaces

    Ho, Yu-Huai; Wang, Lih-Shinn; Jiang, Hui-Li; Chang, Chih-Hui; Hsieh, Chia-Jung; Chang, Dan-Chi; Tu, Hsin-Yu; Chiu, Tan-Yun; Chao, Huei-Jen; Tseng, Chun-Chieh

    2016-01-01

    Contaminated surfaces play an important role in the transmission of pathogens. We sought to establish a criterion that could indicate “cleanliness” using a sampling area–adjusted adenosine triphosphate (ATP) assay. In the first phase of the study, target surfaces were selected for swab sampling before and after daily cleaning; then, an aerobic colony count (ACC) plate assay of bacteria and antibiotic-resistant bacteria was conducted. ATP swabs were also tested, and the ATP readings were reported as relative light units (RLUs). The results of the ACC and ATP assays were adjusted according to the sampling area. During the second phase of the study, a new cleaning process employing sodium dichloroisocyanurate (NaDCC) was implemented for comparison. Using the criterion of 2.5 colony-forming units (CFU)/cm2, 45% of the sampled sites were successfully cleaned during phase one of the study. During phase two, the pass rates of the surface samples (64%) were significantly improved, except under stringent (5 RLU/cm2) and lax (500 RLU) ATP criteria. Using receiver-operating characteristic curve analysis, the best cut-off point for an area-adjusted ATP level was 7.34 RLU/cm2, which corresponded to culture-assay levels of <2.5 CFU/cm2. An area adjustment of the ATP assay improved the degree of correlation with the ACC-assay results from weak to moderate. PMID:27294944

  20. 辨认和控制能力精神医学评定量表划界标准与实证效度%Cut-off point and empirical validity of psychiatric assessment scale of cognitive and volition capacity in crime

    李毅; 高北陵; 胡峰; 李学武; 王轶; 吴冬凌

    2014-01-01

    目的 检验辨认和控制能力精神医学评定量表(Psychiatric Assessment Scale of Cognitive and Volition Capacity in crime,PASCVC)的实证效度,并制定全国常模.方法 于2009年8月至2011年12月间在全国七大行政区的十五家司法鉴定机构共收集评定辨认和控制能力的司法精神鉴定案例1 000例,由量表评定者用PASCVC、精神病人限定刑事责任能力评定量表(Diminished Criminal Responsibility Rating Scale,DCRRS)和暴力作案行为人刑事责任能力评定量表(Criminal Responsibility Rating Scale of Violence,CRRSV)进行评分,所有案例均由鉴定人做出辨认和控制能力完全丧失、大部分丧失、部分丧失、小部分丧失、稍有受损和正常的六个等级判断.结果 ①依据频数分布表的结果得出:辨认和控制能力完全丧失的划界分为≤56、大部分丧失为57~ 66、部分丧失为67~76、小部分丧失为77~ 87、稍有受损为88~ 100、正常为≥101.②六级划界分评定的等级划分结果与专家鉴定意见的相关为0.939 (P=0.001).③PASCVC与DCRRS和CRRSV的一致性Kappa值分别为0.838和0.835 (P<0.001).④PASCVC量表评定和专家评定两种方法分别建立判别函数,回代判别量表与专家判断的正确率分别为86.9%和85.1%;两种分级结果的一致性Kappa值为0.857 (P<0.001).结论 该量表具有较好的实证效度,可作为辨认和控制能力司法鉴定的客观评定工具.%Objective To test the cut-off point and empirical validity of psychiatric assessment scale of cognitive and volition capacity for suspects in crime (PASCVC).Methods One thousand of forensic psychiatry cases from fifteen bodies of the seven administrative regions in China were collected for forensic assessment by the three scales of PASCVC,DCRRS and CRRSV in August 2009 to December 201 l.in all cases by the appraiser to make six grade judgment of the cognitive and volition capacity including completely lost

  1. 疑似糖尿病患者中HbA1c诊断糖尿病应用价值及其切点研究%Validity and Cut-off Point of HbA1c for Early Detection of Suspected Patients with Diabetes Mellitus

    梁国威; 何美琳; 徐旭; 邵冬华

    2012-01-01

    % ). Analysis by Receiver operator characteristic curve for diabetes diagnosis, showed that the area under the curve (AUC) was 0.881 of HbAl c (95% CI: 0.861 -0.900), which was equivalent to that of fasting blood glucose (FPG) (AUC: 0.899, 95% CI; 0.880-0.9160, P=0.205). The sensitivity of using HbAlc ≥ 6. 2% (79.2% ) as the diabetes diagnosis criterion was significantly higher than using FPG≥7.0 mmol/L (65.8% ) or HbAlc≥6.5% (67.4% ). Conclusion HbAlc measurement is suitable for diabetes diagnosis when FPG or OGTT is not available. An HbAl c threshold of 6. 2% is an optimal cut - off point for diabetes diagnosis.

  2. Sustainable urban regime adjustments

    Quitzau, Maj-Britt; Jensen, Jens Stissing; Elle, Morten;

    2013-01-01

    The endogenous agency that urban governments increasingly portray by making conscious and planned efforts to adjust the regimes they operate within is currently not well captured in transition studies. There is a need to acknowledge the ambiguity of regime enactment at the urban scale. This direc...

  3. Auto Adjusting Astronomical Telescope

    Rohit R. Ghalsasi; Prof. N. D. Dhoot

    2014-01-01

    Astronomical telescope is powerful and basic tool for star or celestial observation. Here we proposed integrated system using Raspberry Pi for auto adjusting astronomical telescope. This integrated circuit helps to control stellar monitoring, stellar targeting, and tracking functions of telescope. Astro compass gives the direction of the celestial objects.

  4. Adjustments and Depression

    Full Text Available ... 7309 ☰ Living with Paralysis Get Support Get Involved Research Events Blog & Forum About Us Donate Living with Paralysis > Newly paralyzed > How do I deal with depression and adjustment to my SCI? How do I deal with depression and ...

  5. Auto Adjusting Astronomical Telescope

    Rohit R. Ghalsasi

    2014-04-01

    Full Text Available Astronomical telescope is powerful and basic tool for star or celestial observation. Here we proposed integrated system using Raspberry Pi for auto adjusting astronomical telescope. This integrated circuit helps to control stellar monitoring, stellar targeting, and tracking functions of telescope. Astro compass gives the direction of the celestial objects.

  6. D-二聚体对老年重症社区获得性肺炎30天死亡率的预测价值%Predictivevalue of D-dimer in 30-day mortality of elderly patients with severe community-acquired pneumonia

    龙威; 黄高忠; 李利娟; 苏文涛; 赵立东

    2014-01-01

    目的:探讨D-二聚体水平对住院老年重症社区获得性肺炎(CAP)患者30d死亡率的预测价值。方法152例符合诊断标准的老年重症CAP患者纳入研究,入院后即进行D-二聚体、C-反应蛋白(CRP)检测及肺炎严重度指数(PSI)评分,记录患者30d死亡率。采用受试者工作特征曲线(ROC)分析D-二聚体对30d死亡率的预测价值,计算曲线下面积(AUC)。结果 PSI评分Ⅳ级患者的D-二聚体水平为(961.55±186.49)µg/L,Ⅴ级为(1122.53±197.98)µg/L,两者差异有明显统计学意义(t=5.159,P<0.001);死亡患者的D-二聚体水平(1112.59±215.25)µg/L明显高于存活患者的D-二聚体水平(920.46±126.89)µg/L(t=6.239,P<0.001)。Pearson相关性分析显示,D-二聚体和PSI有明显相关性(r=0.47,P<0.0001);ROC分析表明D-二聚体的AUC为:0.79(95%CI:0.72~0.85),和PSI的AUC相比差异无统计学意义(0.85,95%CI:0.78~0.91,P=0.095)。结论 D-二聚体水平对住院老年重症CAP患者30d死亡率有较好预测价值。%ObjectiveToinvestigate the value ofplasmaD-dimerlevelin predicting 30-day mortalityfortheelderly patients with severe community-acquired pneumonia (CAP).Methods A total of 152 elderly inpatients(over 60 years old)withidentifiedsevere CAPadmitted in our department from August 2009 to August 2011were enrolled in this study.Immediately after admission,theirblood samples were obtained forplasma levels ofD-dimer and C-reactive protein(CRP),and pneumonia severity index (PSI) was calculated. Clinical and laboratory variables and 30-day mortality were recorded.Receiver operating characteristic(ROC) curve was used to assess the value of D-dimerfor predicting 30-day mortality, and thearea under curve(AUC)was calculated.ResultsTheD-dimer levelswere (961.55±186.49)µg/Lin the patients with PSIscore inclassⅣ, and(1122.53±197.98)µg/L for those with score inclass

  7. The validity of Wells'Criteria and Geneva Scoring System (revised) combined with D-dimer in predicting pulmonary embolism%Wells 量表和修正的 Geneva 评分联合 D-二聚体对肺栓塞的预测价值

    凌燕君; 邹晓

    2015-01-01

    目的:评价Wells量表和修正的Geneva评分系统联合D-二聚体诊断肺栓塞的意义。方法应用受试者工作特征曲线,通过Wells量表和修正的Geneva评分系统联合D-二聚体检验方法,得出修正的Geneva和Wells评分,联合D-二聚体阳性来比较两种方法的差别。结果通过Wells评分的ROC曲线得出以≥4.25作为预测值,其灵敏度30.2%,特异度92.6%;通过Geneva评分的ROC曲线得细化以≥6.5作为预测值,其灵敏度64.7%,特异度85.2%。在Wells评分中以最佳分界值4.25分为界,Geneva评分中以最佳分界值6.5分为界,联合D-二聚体检测准确率有明显差别。结论根据Geneva评分≥6.5分或Wells评分≥4.25分者联合D-二聚体阳性时,高度怀疑肺栓塞。%Objective To evaluate the validity of Wells’ Criteria and Geneva Scoring System combined with D-dimer as two different methods for predicting pulmonary embolism.Method The Wells score and the Geneva score were first obtained by the Wells’ Criteria and the Geneva Scoring System ( revised) combined with D – dimer respectively.The validity of the two methods was then evaluated and compared for their difference in accuracy sensitivity, and specificity.Findings The Wells score evaluated by the ROC curve was≥4.25 as the predictive value.Its sensitivity was 30.2%and its specificity of 92.6%.The Geneva score evaluated by the ROC curve was refined to≥6.5 as the predictive value.Its sensitivity was 64. 7%and its specificity of 85.2%.Of the Wells scores the best cutoff value was 4.25 while of the Geneva optimal the optimal cutoff score was 6.5.Combined with D-dimer, significant difference could be found between the two methods. Conclusion The sensitivity and specificity of the revised Geneva score were better than those of the Wells rule.When the revised Geneva scores arrive at a value≥6.5 or the Wells scores arrive a value≥4.25, and the D-dimer is positive

  8. Credit Valuation Adjustment

    Hoffman, Frederick

    2011-01-01

    Credit risk has become a topical issue since the 2007 Credit Crisis, particularly for its impact on the valuation of OTC derivatives. This becomes critical when the credit risk of entities involved in a contract either as underlying or counterparty become highly correlated as is the case during macroeconomic shocks. It impacts the valuation of such contracts through an additional term, the credit valuation adjustment (CVA). This can become large with such correlation. This thesis outlines the...

  9. Adjustable Autonomy Testbed

    Malin, Jane T.; Schrenkenghost, Debra K.

    2001-01-01

    The Adjustable Autonomy Testbed (AAT) is a simulation-based testbed located in the Intelligent Systems Laboratory in the Automation, Robotics and Simulation Division at NASA Johnson Space Center. The purpose of the testbed is to support evaluation and validation of prototypes of adjustable autonomous agent software for control and fault management for complex systems. The AA T project has developed prototype adjustable autonomous agent software and human interfaces for cooperative fault management. This software builds on current autonomous agent technology by altering the architecture, components and interfaces for effective teamwork between autonomous systems and human experts. Autonomous agents include a planner, flexible executive, low level control and deductive model-based fault isolation. Adjustable autonomy is intended to increase the flexibility and effectiveness of fault management with an autonomous system. The test domain for this work is control of advanced life support systems for habitats for planetary exploration. The CONFIG hybrid discrete event simulation environment provides flexible and dynamically reconfigurable models of the behavior of components and fluids in the life support systems. Both discrete event and continuous (discrete time) simulation are supported, and flows and pressures are computed globally. This provides fast dynamic simulations of interacting hardware systems in closed loops that can be reconfigured during operations scenarios, producing complex cascading effects of operations and failures. Current object-oriented model libraries support modeling of fluid systems, and models have been developed of physico-chemical and biological subsystems for processing advanced life support gases. In FY01, water recovery system models will be developed.

  10. Physicians' adjustment to retirement.

    Virshup, B; Coombs, R H

    1993-01-01

    We address the questions, How do physicians adjust to and enjoy their retirement? What factors contribute to the well-being of retired physicians? A 60-item questionnaire mailed to 238 retired physicians in Los Angeles County with a 41.6% response rate assessed health, standard of living, relationships, activities, emotional difficulties, and general enjoyment. Health often improved after retirement, as did relationships with spouses and children. Standard of living was comfortable or better ...

  11. THE DEVELOPMENT OF COMBINED TESTING OF HYPER-SENSITIVE C REACTIVE PROTEIN AND D-DIMER IN ACUTE CORONARY SYMDROME%急性冠脉综合征中超敏C反应蛋白联合D-二聚体检测的研究进展

    杜丽萍; 扈瑞平; 王学磊; 曾显坤

    2015-01-01

    ACS的临床表现可为,胸闷、胸痛伴气短、出汗,心衰,心律失常以及猝死。并伴有冠脉血管痉挛,管腔明显狭窄,甚至完全被堵塞,从而出现心肌缺血缺氧,严重时心肌坏死[1]。近年来研究发现:其进展过程中伴随的生化标记物超敏C反应蛋白、D-二聚体的改变可帮助临床医师及早识别病人的临床症状并为心电图改变不典型病人提供积极个体化的治疗方案,同时对评估其病情及预后、起到极大的作用。现将对急性冠脉综合征中( ACS)超敏C反应蛋白联合D-二聚体检测的研究进展进行综述。%Acute coronary symdrome( ACS) is caused by cononary atherosclerosis rupture, platelet adhesion, platelet aggregation, platelet release, through which the coagulation system is activated leading to the blood clot. ACS is usually accompanied by vasospasm,stenosis of arte-rioles,even worse,myocardial ischemia from completely blocking and myocardial necrosis. The research tells us that through biochemical marker-hyper sensitive C reactive protein and D-dimer ( increase ) , phisician can recognize some symdromes in early time,help ACS patients with atypical ECG changes and give them individual treatment;in addition,the two marker also play an important role in evaluating severity and prognosis. This review will present development in application of hyper-sensitive C reative protein and D-dimer in ACS.

  12. Quantification of microangiopathic lesions in brain parenchyma and age-adjusted mean scores for the diagnostic separation of normal from pathological values in senile dementia

    Purpose: to quantify microangiopathic lesions in the cerebral white matter and to develop age-corrected cut-off values for separating normal from dementia-related pathological lesions. Materials and methods: in a memory clinic, 338 patients were investigated neuropsychiatrically by a psychological test battery and by MRI. Using a FLAIR sequence and a newly developed rating scale, white matter lesions (WMLs) were quantified with respect to localization, number and intensity, and these ratings were condensed into a score. The WML scores were correlated with the mini-mental state examination (MMSE) and clinical dementia rating (CDR) score in dementia patients. A non-linear smoothing procedure was used to calculate age-related mean values and confidence intervals, separate for cognitively intact subjects and dementia patients. Results: the WML scores correlated highly significantly with age in cognitively intact subjects and with psychometric scores in dementia patients. Age-adjusted WML scores of cognitively intact subjects were significantly different from those of dementia patients with respect to the whole brain as well as to the frontal lobe. Mean value and confidence intervals adjusted for age significantly separated dementia patients from cognitively intact subjects over an age range of 54 through 84 years. Conclusion: a rating scale for the quantification of WML was validated and age-adjusted mean values with their confidence intervals for a diagnostically relevant age range were developed. This allows an easy to handle, fast and reliable diagnosis of the vascular component in senile dementia. (orig.)

  13. Adjustment Criterion and Algorithm in Adjustment Model with Uncertain

    SONG Yingchun

    2015-02-01

    Full Text Available Uncertainty often exists in the process of obtaining measurement data, which affects the reliability of parameter estimation. This paper establishes a new adjustment model in which uncertainty is incorporated into the function model as a parameter. A new adjustment criterion and its iterative algorithm are given based on uncertainty propagation law in the residual error, in which the maximum possible uncertainty is minimized. This paper also analyzes, with examples, the different adjustment criteria and features of optimal solutions about the least-squares adjustment, the uncertainty adjustment and total least-squares adjustment. Existing error theory is extended with new observational data processing method about uncertainty.

  14. Jordan Adjusted Human Development

    Ababsa, Myriam

    2014-01-01

    Jordan Human Development Index (HDI) and Adjusted Human Development Index (IHDI) In 1990, the United Nations Development Programme designed a Human Development Index composed of life expectancy at birth, level of education and gross domestic product (GDP) per capita. In 2011, the UNDP ranked Jordan 95th out of 187 countries with a human development index of 0.698, up from 0.591 in 1990, making it the leading medium-range country for human development (fig. VIII.1). In 2010, the inequality adj...

  15. Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis Avaliação dos níveis séricos de D-dímeros entre doentes com urticária crônica, psoríase e urticária vasculite

    Paulo Ricardo Criado

    2013-06-01

    Full Text Available BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE: To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with disease activity. PATIENTS AND METHODS: The study was conducted from October 2010 until March 2011. We selected 37 consecutive patients from our Allergy Unit and Psoriasis Unit, and divided them into three groups for statistical analysis: (i 12 patients with active chronic urticaria (CU; (ii 10 patients with chronic urticaria under remission and (iii 15 patients with psoriasis (a disease with skin inflammatory infiltrate constituted by neutrophils, lymphocytes and monocytes. Another five patients with urticarial vasculitis were allocated in our study, but not included in statistical analysis. The serum levels of D-dimer were measured by Enzyme Linked Fluorescent Assay (ELFA, and the result units were given in ng/ml FEU. RESULTS: Patients with active chronic urticaria had the highest serum levels of D-dimer (p FUNDAMENTOS: Tem sido demonstrado que os neutrófilos, eosinófilos e monócitos, sob estímulo apropriado, podem expressar fator tecidual e, portanto, ativar a via extrínseca da coagulação. Realizamos um estudo transversal e caso-controle de pacientes com urticária crônica e pacientes com psoríase em nosso ambulatório para avaliar a produção de dímero-D. OBJETIVO: Avaliar níveis de dímero-D em pacientes com urticária crônica e sua possível correlação com a atividade da doença. PACIENTES E MÉTODOS: O estudo foi conduzido de outubro de 2010 até março de 2011. Nós selecionamos 37 pacientes consecutivos da Unidade de Alergia e Unidade de

  16. Continuously adjustable Pulfrich spectacles

    Jacobs, Ken; Karpf, Ron

    2011-03-01

    A number of Pulfrich 3-D movies and TV shows have been produced, but the standard implementation has inherent drawbacks. The movie and TV industries have correctly concluded that the standard Pulfrich 3-D implementation is not a useful 3-D technique. Continuously Adjustable Pulfrich Spectacles (CAPS) is a new implementation of the Pulfrich effect that allows any scene containing movement in a standard 2-D movie, which are most scenes, to be optionally viewed in 3-D using inexpensive viewing specs. Recent scientific results in the fields of human perception, optoelectronics, video compression and video format conversion are translated into a new implementation of Pulfrich 3- D. CAPS uses these results to continuously adjust to the movie so that the viewing spectacles always conform to the optical density that optimizes the Pulfrich stereoscopic illusion. CAPS instantly provides 3-D immersion to any moving scene in any 2-D movie. Without the glasses, the movie will appear as a normal 2-D image. CAPS work on any viewing device, and with any distribution medium. CAPS is appropriate for viewing Internet streamed movies in 3-D.

  17. The Design of Fiscal Adjustments

    Alesina, Alberto Francesco; Ardagna, Silvia

    2013-01-01

    This paper offers three results. First, in line with the previous literature, we confirm that fiscal adjustments based mostly on the spending side are less likely to be reversed. Second, spending based fiscal adjustments have caused smaller recessions than tax based fiscal adjustments. Finally, certain combinations of policies have made it possible for spending based fiscal adjustments to be associated with growth in the economy even on impact rather than with a recession. Thus, expansionary ...

  18. Technical Document for Price Adjustment

    Zheng Tian; Mulugeta Kahsai; Randall Jackson

    2014-01-01

    This document presents the basis for the price adjustment mechanisms in a time series IO model. The essentials of the price adjustment and price change propagation algorithms are presented, along with a matrix permutation algorithm that facilitates the implementation of the price adjustment mechanism. The Matlab function is provided.

  19. Metric adjusted skew information

    Hansen, Frank

    2008-01-01

    We extend the concept of Wigner-Yanase-Dyson skew information to something we call "metric adjusted skew information" (of a state with respect to a conserved observable). This "skew information" is intended to be a non-negative quantity bounded by the variance (of an observable in a state) that...... vanishes for observables commuting with the state. We show that the skew information is a convex function on the manifold of states. It also satisfies other requirements, proposed by Wigner and Yanase, for an effective measure-of-information content of a state relative to a conserved observable. We...... establish a connection between the geometrical formulation of quantum statistics as proposed by Chentsov and Morozova and measures of quantum information as introduced by Wigner and Yanase and extended in this article. We show that the set of normalized Morozova-Chentsov functions describing the possible...

  20. Adjusting to the Emergent

    Revsbæk, Line

    In her doctoral thesis Line Revsbaek explores newcomer innovation related to organizational entry processes in a changing organization. She introduces process philosophy and complexity theory to research on organizational socialization and newcomer innovation. The study challenges assumptions...... in standardized induction programs where newcomers are cast in roles as insecure novices needing to be “taught the ropes” of the organizational culture. Linked with this, it is suggested that the prevailing dichotomy of ‘newcomer assimilation’ versus ‘organizational accommodation’ is replaced with a notion...... of ‘adjusting to the emergent’. Newcomer innovation is portrayed as carrying a variety of possible significations, such as unintentional innovation effects of newcomer’s proactive self-socializing behavior; an inspirational basis for designing innovation-generating employee induction; ‘resonant instances...

  1. Up/down conversion switching by adjusting the pulse width of red laser beams in LaF₃:Tm³⁺ nanocrystals.

    Gao, Dangli; Tian, Dongping; Xiao, Guoqing; Chong, Bo; Yu, Genghua; Pang, Qing

    2015-08-01

    We demonstrate a versatile approach to fine-tuning the ratio of blue to near-infrared emission intensity from Tm3+ ions in LaF3 nanocrystals by adjusting the pulse widths and excitation wavelengths of red laser beams. The mechanism of color-tunable Tm3+ emission by pulse widths is explored, and a mechanism based on promoting the population of some luminescence levels and cutting off the population of others by suitably adjusting pulse duration is proposed. The underlying reason of excitation wavelength-modulated emission is ascribed to tuning absorption probability ratio of ground state absorption to excited state absorption by tuning the matching degree between the energies of excitation wavelength and ground (excited) state absorption of Tm3+. The ability of our LaF3:Tm3+ nanocrystals to emit variable emissions on demand in response to pulse width and excitation wavelength provides keen insights into controlling the population processes of luminescent levels and offers a versatile approach for tuning the spectral output. PMID:26258362

  2. Delay Adjusted Incidence Infographic

    This Infographic shows the National Cancer Institute SEER Incidence Trends. The graphs show the Average Annual Percent Change (AAPC) 2002-2011. For Men, Thyroid: 5.3*,Liver & IBD: 3.6*, Melanoma: 2.3*, Kidney: 2.0*, Myeloma: 1.9*, Pancreas: 1.2*, Leukemia: 0.9*, Oral Cavity: 0.5, Non-Hodgkin Lymphoma: 0.3*, Esophagus: -0.1, Brain & ONS: -0.2*, Bladder: -0.6*, All Sites: -1.1*, Stomach: -1.7*, Larynx: -1.9*, Prostate: -2.1*, Lung & Bronchus: -2.4*, and Colon & Rectum: -3/0*. For Women, Thyroid: 5.8*, Liver & IBD: 2.9*, Myeloma: 1.8*, Kidney: 1.6*, Melanoma: 1.5, Corpus & Uterus: 1.3*, Pancreas: 1.1*, Leukemia: 0.6*, Brain & ONS: 0, Non-Hodgkin Lymphoma: -0.1, All Sites: -0.1, Breast: -0.3, Stomach: -0.7*, Oral Cavity: -0.7*, Bladder: -0.9*, Ovary: -0.9*, Lung & Bronchus: -1.0*, Cervix: -2.4*, and Colon & Rectum: -2.7*. * AAPC is significantly different from zero (p<.05). Rates were adjusted for reporting delay in the registry. www.cancer.gov Source: Special section of the Annual Report to the Nation on the Status of Cancer, 1975-2011.

  3. Metric-adjusted skew information

    Liang, Cai; Hansen, Frank

    2010-01-01

    We give a truly elementary proof of the convexity of metric-adjusted skew information following an idea of Effros. We extend earlier results of weak forms of superadditivity to general metric-adjusted skew information. Recently, Luo and Zhang introduced the notion of semi-quantum states on a...... bipartite system and proved superadditivity of the Wigner-Yanase-Dyson skew informations for such states. We extend this result to the general metric-adjusted skew information. We finally show that a recently introduced extension to parameter values 1 < p = 2 of the WYD-information is a special case of...... (unbounded) metric-adjusted skew information....

  4. Adjustment computations spatial data analysis

    Ghilani, Charles D

    2011-01-01

    the complete guide to adjusting for measurement error-expanded and updated no measurement is ever exact. Adjustment Computations updates a classic, definitive text on surveying with the latest methodologies and tools for analyzing and adjusting errors with a focus on least squares adjustments, the most rigorous methodology available and the one on which accuracy standards for surveys are based. This extensively updated Fifth Edition shares new information on advances in modern software and GNSS-acquired data. Expanded sections offer a greater amount of computable problems and their worked solu

  5. Variance Adjusted Actor Critic Algorithms

    Tamar, Aviv; Mannor, Shie

    2013-01-01

    We present an actor-critic framework for MDPs where the objective is the variance-adjusted expected return. Our critic uses linear function approximation, and we extend the concept of compatible features to the variance-adjusted setting. We present an episodic actor-critic algorithm and show that it converges almost surely to a locally optimal point of the objective function.

  6. Mood Adjustment via Mass Communication.

    Knobloch, Silvia

    2003-01-01

    Proposes and experimentally tests mood adjustment approach, complementing mood management theory. Discusses how results regarding self-exposure across time show that patterns of popular music listening among a group of undergraduate students differ with initial mood and anticipation, lending support to mood adjustment hypotheses. Describes how…

  7. Bayes linear covariance matrix adjustment

    Wilkinson, Darren J

    1995-01-01

    In this thesis, a Bayes linear methodology for the adjustment of covariance matrices is presented and discussed. A geometric framework for quantifying uncertainties about covariance matrices is set up, and an inner-product for spaces of random matrices is motivated and constructed. The inner-product on this space captures aspects of our beliefs about the relationship between covariance matrices of interest to us, providing a structure rich enough for us to adjust beliefs about unknown matrices in the light of data such as sample covariance matrices, exploiting second-order exchangeability and related specifications to obtain representations allowing analysis. Adjustment is associated with orthogonal projection, and illustrated with examples of adjustments for some common problems. The problem of adjusting the covariance matrices underlying exchangeable random vectors is tackled and discussed. Learning about the covariance matrices associated with multivariate time series dynamic linear models is shown to be a...

  8. Adjusting CA19-9 values to predict malignancy in obstructive jaundice: Influence of bilirubin and C-reactive protein

    Gaetano La Greca; Maria Sofia; Rosario Lombardo; Saverio Latteri; Agostino Ricotta; Stefano Puleo; Domenico Russello

    2012-01-01

    AIM:To find a possible relationship between inflammation and CA19-9 tumor marker by analyzing data from patients with benign jaundice (BJ) and malignant jaundice (MJ).METHODS:All patients admitted for obstructive jaundice,in the period 2005-2009,were prospectively enrolled in the study,obtaining a total of 102 patients.On admission,all patients underwent complete standard blood test examinations including C-reactive protein (CRP),bilirubin,CA19-9.Patients were considered eligible for the study when they presented obstructive jaundice confirmed by instrumental examinations and increased serum bilirubin levels (total bilirubin > 2.0 mg/dL).The standard cut-off level for CA19-9 was 32 U/mL,whereas for CRP this was 1.5 mg/L.The CA19-9 level was adjusted by dividing it by the value of serum bilirubin or by the CRP value.The patients were divided into 2 groups,MJ and BJ,and after the adjustment a comparison between the 2 groups of patients was performed.Sensitivity,specificity and positive predictive values were calculated before and after the adjustment.RESULTS:Of the 102 patients,51 were affected by BJ and 51 by MJ.Pathologic CA19-9 levels were found in 71.7% of the patients.In the group of 51 BJ patients there were 29 (56.9%) males and 22 (43.1%) females with a median age of 66 years (range 24-96 years),whereas in the MJ group there were 24 (47%) males and 27 (53%) females,with a mean age of 70 years (range 30-92 years).Pathologic CA19-9 serum level was found in 82.3% of MJ.CRP levels were pathologic in 66.6% of the patients with BJ and in 49% with MJ.Bilirubin and CA19-9 average levels were significantly higher in MJ compared with BJ (P =0.000 and P =0.02),while the CRP level was significantly higher in BJ (P =0.000).Considering a CA19-9 cut-off level of 32 U/mL,82.3% in the MJ group and 54.9% in the BJ group were positive for CA19-9 (P =0.002).A CA19-9 cut-off of 100 U/mL increases the difference between the two groups:35.3% in BJ and 68.6

  9. Adjustable Induction-Heating Coil

    Ellis, Rod; Bartolotta, Paul

    1990-01-01

    Improved design for induction-heating work coil facilitates optimization of heating in different metal specimens. Three segments adjusted independently to obtain desired distribution of temperature. Reduces time needed to achieve required temperature profiles.

  10. Adjustment to Spinal Cord Injury

    ... may need to work to help with family finances. All of the changes that they face can ... 2000). Goal instability and adjustment to physical disability. Journal of Counseling Psychology, 47(2). 251-265. This ...

  11. Adjustment techniques for experimental data

    To carry through numerically the different adjustment of experimental data planned by National Institute of Nuclear Research investigators. It is presented the different adjustment techniques of experimental data which are fundamentally for: linear least squares, non linear with restrictions. Methodology: Lineal least squares - Orthogonal decomposition via Householder reflections. No lineal - Method of general lowering and quasi Newton; Levenberg-Marquardt modified - More version. No lineal with restrictions - Quadratic sequential programming method (In process). (Author)

  12. 7 CFR 251.7 - Formula adjustments.

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Formula adjustments. 251.7 Section 251.7 Agriculture... GENERAL REGULATIONS AND POLICIES-FOOD DISTRIBUTION THE EMERGENCY FOOD ASSISTANCE PROGRAM § 251.7 Formula adjustments. Formula adjustments. (a) Commodity adjustments. The Department will make annual adjustments...

  13. MCCB warm adjustment testing concept

    Erdei, Z.; Horgos, M.; Grib, A.; Preradović, D. M.; Rodic, V.

    2016-08-01

    This paper presents an experimental investigation in to operating of thermal protection device behavior from an MCCB (Molded Case Circuit Breaker). One of the main functions of the circuit breaker is to assure protection for the circuits where mounted in for possible overloads of the circuit. The tripping mechanism for the overload protection is based on a bimetal movement during a specific time frame. This movement needs to be controlled and as a solution to control this movement we choose the warm adjustment concept. This concept is meant to improve process capability control and final output. The warm adjustment device design will create a unique adjustment of the bimetal position for each individual breaker, determined when the testing current will flow thru a phase which needs to trip in a certain amount of time. This time is predetermined due to scientific calculation for all standard types of amperages and complies with the IEC 60497 standard requirements.

  14. Tax Adjusted for Imported Equipment

    2010-01-01

    @@ Ministry of Finance, Central Administration of Customs, and State Administration of Taxation of P.R. of China jointly issued a "Notice on the Lists Related to the Interim Provisions on the Adjustment of Import Tax Policy on Major Technical Equipment" (the Notice) on April 13rd to adjust the list of equipment catalog and merchandise attached to the "Interim Provisions on the Import Tax Policy on Major Technical Equipment", as well as the preferential scope and extent of the import tax on a number of major technical equipment.

  15. 75 FR 33379 - Railroad Cost Recovery Procedures-Productivity Adjustment; Quarterly Rail Cost Adjustment Factor

    2010-06-11

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment; Quarterly Rail... Railroads that the Board restate the previously published productivity adjustment for the 2003-2007 averaging period (2007 productivity adjustment) so that it tracks the 2007 productivity adjustment...

  16. Dynamics of magnetostatic wave solitons in the vicinity of frequency cut-off

    Burlak, G; Koshevaya, S; Marquez-Aguilar, P

    2001-01-01

    Nonlinear dynamics of one-dimensional pulses of exchangeless backward volume magnetostatic waves propagating in thin ferrite films with a thickness 2l=(3-10) mu m is studied numerically. The Whitham's approach of taking into account the exact wave dispersion is utilized. It has been found that in the case of small wave numbers (0.02=0.1), the nonlinear wave dynamics coincides with results obtained earlier in the parabolic approximation for the wave dispersion. Two-dimensional dynamics of nonlinear pulses is also investigated briefly in the full dispersion approach. The collapse-like phenomena have been found there when the central wave number is chosen as k sub 0 l>=0.04.

  17. Overcoming the Cut-Off Charge Transfer Bandgaps at the PbS Quantum Dot Interface

    El-Ballouli, Ala'a O.

    2015-11-17

    Light harvesting from large size of semiconductor PbS quantum dots (QDs) with a bandgap of less than 1 eV is one of the greatest challenges precluding the development of PbS QD-based solar cells because the interfacial charge transfer (CT) from such QDs to the most commonly used electron acceptor materials is very inefficient, if it occurs at all. Thus, an alternative electron-accepting unit with a new driving force for CT is urgently needed to harvest the light from large-sized PbS QDs. Here, a cationic porphyrin is utilized as a new electron acceptor unit with unique features that bring the donor–acceptor components into close molecular proximity, allowing ultrafast and efficient electron transfer for QDs of all sizes, as inferred from the drastic photoluminescence quenching and the ultrafast formation of the porphyrin anionic species. The time-resolved results clearly demonstrate the possibility of modulating the electron transfer process between PbS QDs and porphyrin moieties not only by the size quantization effect but also by the interfacial electrostatic interaction between the positively charged porphyrin and the negatively charged QDs. This approach provides a new pathway for engineering QD-based solar cells that make the best use of the diverse photons making up the Sun\\'s broad irradiance spectrum.

  18. From Newton's law to the linear Boltzmann equation without cut-off

    Ayi, Nathalie

    2016-01-01

    We provide a rigorous derivation of the linear Boltzmann equation without cutoff starting from a system of particles interacting via a potential with infinite range as the number of particles N goes to infinity under the Boltzmann-Grad scaling. The main difficulty in our context is that, due to the infinite range of the potential, a non-integrable singularity appears in the angular collision kernel, making no longer valid the single-use of Lanford's strategy. Our proof relies then on a combin...

  19. Serum Cholesterol Level Nomograms for Iranian Population; Suggestion for National Cut-Offs

    Mostafa Hosseini; Shervin Taslimi; Mahmoud Yousefifard; Fereshteh Asgari; Koorosh Etemad; Hamid Heidarian Miri; Ali Rafei; Jalil Koohpayehzadeh; Iman Navid; Mohammad Mehdi Gouya

    2013-01-01

    Background: High cholesterol levels are associated with increased risk of coronary heart disease and stroke. Understanding the distribution of serum cholesterol levels in each country is valuable index for use in public health planning. This study aimed to construct nomograms of total cholesterol (TC) levels and establish the cut-points specific to Iranian population. Methods: Data on serum TC levels of 19,630 non-institutionalized individuals aged 25–64 years from third national survey on no...

  20. Serum Cholesterol Level Nomograms for Iranian Population; Suggestion for National Cut-Offs

    Mostafa Hosseini

    2013-02-01

    Full Text Available Background: High cholesterol levels are associated with increased risk of coronary heart disease and stroke. Understanding the distribution of serum cholesterol levels in each country is valuable index for use in public health planning. This study aimed to construct nomograms of total cholesterol (TC levels and establish the cut-points specific to Iranian population.Methods: Data on serum TC levels of 19,630 non-institutionalized individuals aged 25-64 years from third national survey on non-communicable diseases (SuRFNCD in 2007 were used to construct cholesterol nomograms. We proposed cutoff values for borderline and high TC levels based on rounded 75th and 90th percentiles in three age groups (25-34, 35-44 and 45-64 respectively.Results: Average yearly increase of TC for males up to the age of 45 and females up to 64 were 1.15 and 1.03 mg/dl, respectively. TC levels were higher in females. In males, cutoff values for "borderline and high" TC levels were 195 and 220 mg/dl in 25-34, 210 and 240 mg/d in 35-44 and 215 and 245 mg/dl in 45-64 years old individuals. In women, these values were 200 and 225 mg/dl in 25-34,215 and 240 mg/dl in 35-44 and 235 and 265 mg/dl in 45-64 years old individuals respectively.Conclusion: Since TC levels are different in two sexes and change with age, we proposed different cutoffs for sex and age group. We think these cutoffs could be used in national public health planning.

  1. Interstellar Flow Longitude from the Symmetry of the Pickup Ion Cut-off at 1 AU

    Möbius, E.; Lee, M. A.; Drews, C.

    2015-12-01

    We provide a proof of concept that the pickup ion (PUI) cutoff speed variation with ecliptic longitude can provide the interstellar neutral (ISN) flow longitude {λ }{ISN∞ } outside the heliosphere with a precision of the order of 0.°1. We compare 2007-2014 STEREO A PLASTIC observations in the solar wind frame with a simple analytical cutoff model and perform a Pearson correlation of the cutoff as a function of longitude with those values mirrored about a location λM that slides in longitude. The resulting maximum correlation at λM = 255.°21 ± 0.°04 reflects the ISN upwind direction with a purely statistical uncertainty. This result is consistent with recent ISN flow longitude values, but a precision determination requires the evaluation of underlying systematic effects. Obtaining a precision ISN flow longitude is highly complementary to the IBEX ISN observations, which return a narrow tube in the ISN parameter space that couples flow speed and longitude tightly, but leaves a substantially larger error bar along the tube. The ISN flow provides one cardinal axis of the heliosphere, with a strong leverage on the plane subtended by the ISN velocity and the interstellar magnetic field vector, which controls the shape of the heliosphere and its interaction with the interstellar medium. In addition, a discussion about potential temporal variations of the ISN flow has started. Both issues require a precision determination of the ISN flow velocity over decade-long time intervals. ACE SWICS, STEREO PLASTIC, and SOHO CTOF PUI data allow such long-term studies over almost two decades.

  2. High Frequency Cut-off and Changing of Radio Emission Mechanism in Pulsars

    Kontorovich, V M

    2012-01-01

    Pulsars are the fast rotating neutron stars with strong magnetic field emitting over a wide frequency range. In spite of the efforts during 40 years after the discovery of pulsars, the mechanism of their radio emission remains to be unknown so far. We propose a new approach to solving this problem. The object of our study is a sample of pulsars with a high-frequency break of the spectrum from Pushchino catalogue. A theoretical explanation of the observed dependence of the high-frequency break from the pulsar period is given. The dependence of the break position from the magnetic field is predicted. This explanation is based on a new mechanism for electron emission in the inner polar gap. Radiation occurs when electrons are accelerated in the electric field rising from zero at the star surface. Acceleration passes through a maximum and tends to zero when the electron velocity approaches the velocity of light. The all radiated power is allocated to the radio band. The averaging over the polar cap, with some nat...

  3. Sliding Wear Properties of Graphite as Sealing Materials for Cut off Hot Gas

    Sealing structure to prevent flowing hot gas into the driving device, located between the driving shaft and the liner of On-Off valve for controlling the hot gas flow path was studied. Wear occurs due to the constant movement of the driving shaft controlled by actuator on graphite as the sealing material. In this paper, the dynamic wear behavior in high temperature of graphite(HK-6) to be used as sealing material was evaluated. Reciprocating wear test was carried out for the graphite(HK-6) to the relative motion between shaft materials(W-25Re). The results of friction coefficient and specific wear rate according to contact load, sliding speed at room temperature and 485 .deg. C considering the actual operating environment were evaluated. Through the SEM analysis of the worn surface, third body as lubricant films were observed and lubricant effect of third body was considered

  4. Cut off values of waist circumference & associated cardiovascular risk in egyptians

    Ibrahim M

    2011-08-01

    Full Text Available Abstract Background Recent guidelines stressed the need to adopt different values of waist circumference (WC measurements to define abdominal obesity in different ethnic groups. The aim of this study is to identify WC cutoff points in normotensive and hypertensive subjects which are diagnostic of abdominal obesity in a Middle Eastern population and the prevalence of abdominal obesity in a nationwide sample. Methods Data were collected during phase-2 of the Egyptians National Hypertension Project survey. Blood pressure, anthropometric measurements and laboratory studies were performed according to a standardized protocol by trained personnel. To derive the cutoff points for WC, we applied the factor analysis on CV risk factors: diabetes mellitus, decrease in HDL-C and increase in LDL-C, triglycerides and left ventricular mass index by echocardiography. Results The sample included 2313 individuals above the age of 25 years. WC values (mean ± SD were 88 ± 14 cm and 95 ± 14 cm for normotensive (NT and hypertensive (HT men respectively, and 89.6 ± 14.7 cm and 95.7 ± 15.9 cm for NT and HT women respectively. Applying factor analysis, the weighted average cutoff points were 93.5 cm for both NT and HT men and 91.5 and 92.5 cm for NT and HT women respectively. Based on these thresholds, the prevalence of abdominal obesity was 48% in men and 51.5% in women. Conclusion This is the first report of specific abdominal obesity cutoff points in a Middle Eastern country. The cutoff points were different from the Europid standards. There is a high prevalence rate of abdominal obesity among Egyptians which is associated with increased prevalence of cardiometabolic risk factors.

  5. Metabolic syndrome: no internationally defined standard cut-off value for waist circumference

    Olabode Oladeinde

    2007-01-01

    @@ The metabolic syndrome (MS) is a cluster of interrelated risk factors of metabolic origin - metabolic risk factors that appear to directly promote the development of atherosclerotic cardiovascular disease and increase the risk of development of type 2 diabetes.

  6. Refining Game Addiction Questionnairs: Evidence for a natural cut-off point?

    Nielsen, Rune Kristian

    2013-01-01

    This paper presents data from a pilot study, which was designed to illuminate critical flaws in the currently used instruments used to measure the prevalence of ‘computer game addiction’. The study found that the prevalence rate could be set anywhere between 23% and 0,6% depending on how the data...... is unique in the field of prevalence studies of computer game addiction both in its design and its findings. The findings and conclusions need to be addressed by future research in the area....

  7. Arctic cut-off high drives the poleward shift of a new Greenland melting record

    Tedesco, M.; Mote, T.; Fettweis, X.; Hanna, E.; Jeyaratnam, J.; Booth, J. F.; Datta, R.; Briggs, K.

    2016-06-01

    Large-scale atmospheric circulation controls the mass and energy balance of the Greenland ice sheet through its impact on radiative budget, runoff and accumulation. Here, using reanalysis data and the outputs of a regional climate model, we show that the persistence of an exceptional atmospheric ridge, centred over the Arctic Ocean, was responsible for a poleward shift of runoff, albedo and surface temperature records over the Greenland during the summer of 2015. New records of monthly mean zonal winds at 500 hPa and of the maximum latitude of ridge peaks of the 5,700+/-50 m isohypse over the Arctic were associated with the formation and persistency of a cutoff high. The unprecedented (1948-2015) and sustained atmospheric conditions promoted enhanced runoff, increased the surface temperatures and decreased the albedo in northern Greenland, while inhibiting melting in the south, where new melting records were set over the past decade.

  8. Appoximation of individual cascades with energies above the GZK cut-off

    Kirillov, A.; Kirillov, I.

    Approximation of individual cascades of gigantic energies is the essential part of prime particle energy determination methods. Fluctuation of cascades and their distribution shapes were investigated on the base of sufficient number of MK simulated showers, as dependent on prime energy, zenit angle and registration method. Individual cascades were approximated with high accuracy using some special parameters. It enables to create convenient formulae for approximation of individual cascades. Quality of this approximation and applicability of the traditional approximation of mean cascades for estimation of individual giganticcascades are discussed.

  9. An adjustable contracted CI method

    王育彬; 甘正汀; 苏克和; 文振翼

    1999-01-01

    A new contracted CI scheme——adjustable contracted CI scheme——is presented and programed. The efficiency of this scheme is tested by some example calculations. The result shows that the application of the new scheme is flexible and the correlation energy loss is lower than that of the original externally contracted CI method.

  10. Self-Adjusting Stack Machines

    Hammer, Matthew A; Chen, Yan; Acar, Umut A

    2011-01-01

    Self-adjusting computation offers a language-based approach to writing programs that automatically respond to dynamically changing data. Recent work made significant progress in developing sound semantics and associated implementations of self-adjusting computation for high-level, functional languages. These techniques, however, do not address issues that arise for low-level languages, i.e., stack-based imperative languages that lack strong type systems and automatic memory management. In this paper, we describe techniques for self-adjusting computation which are suitable for low-level languages. Necessarily, we take a different approach than previous work: instead of starting with a high-level language with additional primitives to support self-adjusting computation, we start with a low-level intermediate language, whose semantics is given by a stack-based abstract machine. We prove that this semantics is sound: it always updates computations in a way that is consistent with full reevaluation. We give a comp...

  11. Adjustable Optical-Fiber Attenuator

    Buzzetti, Mike F.

    1994-01-01

    Adjustable fiber-optic attenuator utilizes bending loss to reduce strength of light transmitted along it. Attenuator functions without introducing measurable back-reflection or insertion loss. Relatively insensitive to vibration and changes in temperature. Potential applications include cable television, telephone networks, other signal-distribution networks, and laboratory instrumentation.

  12. Adjustment or updating of models

    D J Ewins

    2000-06-01

    In this paper, first a review of the terminology used in the model adjustment or updating is presented. This is followed by an outline of the major updating algorithms cuurently available, together with a discussion of the advantages and disadvantages of each, and the current state-of-the-art of this important application and part of optimum design technology.

  13. 12 CFR 19.240 - Inflation adjustments.

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Inflation adjustments. 19.240 Section 19.240... PROCEDURE Civil Money Penalty Inflation Adjustments § 19.240 Inflation adjustments. (a) The maximum amount... Civil Penalties Inflation Adjustment Act of 1990 (28 U.S.C. 2461 note) as follows: ER10NO08.001 (b)...

  14. Multi-toning Image Adjustment

    LIU Shi-guang; WANG Xiao-juan; PENG Qun-sheng

    2011-01-01

    Due to the different lighting environments or other reasons, the pixel colors may be quite different in one image which causes distinct visual discontinuities. It makes the analysis and processing of such an image more difficult and sometime impossible. In this paper, a unified multi-toning image adjustment method is proposed to solve this problem. First, a novel unsupervised clustering method was proposed to partition the source and the target image into a certain number of subsets with similar color statistics. By matching the texture characteristics and luminance distribution between the blocks, it can create optimized correspondence. Then, the color information was transferred from the matched pixels in the source blocks to the target ones. Graph cut method was used to optimize the seams between different subsets in the final step. This method can automatically perform color adjustment of a multi-toning image. It is simple and efficient. Various results show the validity of this method.

  15. Control of Adjustable Compliant Actuators

    Berno J.E. Misgeld; Kurt Gerlach-Hahn; Daniel Rüschen; Anake Pomprapa; Steffen Leonhardt

    2014-01-01

    Adjustable compliance or variable stiffness actuators comprise an additional element to elastically decouple the actuator from the load and are increasingly applied to human-centered robotic systems. The advantages of such actuators are of paramount importance in rehabilitation robotics, where requirements demand safe interaction between the therapy system and the patient. Compliant actuator systems enable the minimization of large contact forces arising, for example, from muscular spasticity...

  16. Parenting Perfectionism and Parental Adjustment

    Lee, Meghan A.; Schoppe-Sullivan, Sarah J.; Kamp Dush, Claire M.

    2012-01-01

    The parental role is expected to be one of the most gratifying and rewarding roles in life. As expectations of parenting become ever higher, the implications of parenting perfectionism for parental adjustment warrant investigation. Using longitudinal data from 182 couples, this study examined the associations between societal- and self-oriented parenting perfectionism and new mothers’ and fathers’ parenting self-efficacy, stress, and satisfaction. For mothers, societal-oriented parenting perf...

  17. Focal Adjustment for Star Tracker

    Liu Hai-bo; Jian-kun Yang; Ji-chun Tan; De-zhi Su; Wen-liang Wang; Xiu-jian Li; Hui Jia

    2010-01-01

    Technique of measuring intensity distribution and size of spot image developed has been discussed, which is especially suitable for defocus adjustment in ground test of star tracker. A novel approach for choosing a proper defocusing position has been proposed based on collimator, Gaussian surface fitting method, and other ordinary instruments. It proves to be practical and adequate in the development of distant object tracking such as star tracker.Defence Science Journal, 2010, 60(6), pp.678-...

  18. Adjustable extender for instrument module

    A blank extender module used to mount an instrument module in front of its console for repair or test purposes has been equipped with a rotatable mount and means for locking the mount at various angles of rotation for easy accessibility. The rotatable mount includes a horizontal conduit supported by bearings within the blank module. The conduit is spring-biased in a retracted position within the blank module and in this position a small gear mounted on the conduit periphery is locked by a fixed pawl. The conduit and instrument mount can be pulled into an extended position with the gear clearing the pawl to permit rotation and adjustment of the instrument

  19. Focal Adjustment for Star Tracker

    Liu Hai-bo

    2010-10-01

    Full Text Available Technique of measuring intensity distribution and size of spot image developed has been discussed, which is especially suitable for defocus adjustment in ground test of star tracker. A novel approach for choosing a proper defocusing position has been proposed based on collimator, Gaussian surface fitting method, and other ordinary instruments. It proves to be practical and adequate in the development of distant object tracking such as star tracker.Defence Science Journal, 2010, 60(6, pp.678-682, DOI:http://dx.doi.org/10.14429/dsj.60.36

  20. A computerized adjustable brain atlas

    A computerized brain atlas, adjustable to the patients anatomy, has been developed. It is primarily intended for use in positron emission tomography, but may also be employed in other fields utilizing neuro imaging, such as sterotactic surgery, transmission computerized tomography (CT) and magnetic resonance imaging (MRI). The atlas is based on anatomical information obtained from digitized cryosectioned brains. It can be adjusted to fit a wide range of images from individual brains with normal anatomy. The corresponding transformation is chosen so that the modified atlas agrees with a set of CT or NMR images of the patient. The computerized atlas can be used to improve the quantification and evaluation of PET data by: Aiding and improving the selection of regions of interests. Facilitating comparisons of functional image data from different individuals or groups of individuals. Facilitating the comparison of different examinations of the same patient, thus reducing the need of reproducible fixation systems. Providing external a priori anatomical information to be used in the image reconstruction. Improving the attenuation and scatter corrections. Aiding in selecting a suitable patient orientation during the PET study. By applying the inverse atlas transformation to PET data set it is possible to relate the PET information to the anatomy of the reference atlas. Reformatted PET data from different patients can thus be averaged, and averages from different categories of patients can be compared. The method will facilitate the identification of statistically significant differences in the PET information from different groups of patients. (orig.)

  1. 48 CFR 1450.103 - Contract adjustments.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract adjustments. 1450.103 Section 1450.103 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT... Contract adjustments....

  2. Labour Adjustment Costs and British Footwear Protection

    Winters, L. Alan

    1990-01-01

    Import protection is frequently advocated as a means of preserving jobs and avoiding labour adjustment costs. Defining adjustment costs in terms of output forgone during the process of adjustment and ignoring any general equilibrium repercussions, we estimate that quantitative restrictions on British footwear imports during 1979 protected about 1,000 jobs and avoided once-and-for-all adjustment costs of only around 1 million pounds sterling. The result is based on new data which reveal high r...

  3. Anchoring Adjusted Capital Asset Pricing Model

    Hammad, Siddiqi

    2015-01-01

    An anchoring adjusted Capital Asset Pricing Model (ACAPM) is developed in which the payoff volatilities of well-established stocks are used as starting points that are adjusted to form volatility judgments about other stocks. Anchoring heuristic implies that such adjustments are typically insufficient. ACAPM converges to CAPM with correct adjustment, so CAPM is a special case of ACAPM. The model provides a unified explanation for the size, value, and momentum effects in the stock market. A ke...

  4. 12 CFR 1780.80 - Inflation adjustments.

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Inflation adjustments. 1780.80 Section 1780.80... DEVELOPMENT RULES OF PRACTICE AND PROCEDURE RULES OF PRACTICE AND PROCEDURE Civil Money Penalty Inflation Adjustments § 1780.80 Inflation adjustments. The maximum amount of each civil money penalty within...

  5. Dimensions of Adjustment among College Women.

    Tomlinson-Clarke, Saundra

    1998-01-01

    Examines academic, social, and personal-emotional adjustment, as well as institutional attachment for women (N=198) attending a predominantly white coeducational research university. Significant main effects were found on academic achievement for year in college. Students differed on personal-emotional adjustment by race. Academic adjustment and…

  6. Neighborhood Assets and Adolescent Adjustment

    Alfredo Oliva Delgado

    2011-12-01

    Full Text Available This paper presents the results of a study analyzing the relationship between some dimensions or developmental assets in the neighborhood, as measured by the Scale for the Assessment of Developmental Assets in the Neighborhood, and adjustment and life satisfaction of adolescent boys and girls. The sample consisted of 2400 adolescents (1068 boys and 1332 girls between ages 12 and 17 who were secondary students in public and private schools in Western Andalusia. The results showed significant relationships between most dimensions of the scale (youth empowerment, attachment to neighbourhood safety and social control and internalizing and externalizing problems, substance use and life satisfaction of participants. Moreover, the data provide evidence about the external validity of the scale used in the study. From the results some suggestions for intervention in the community environment are extracted.

  7. Culture, emotion regulation, and adjustment.

    Matsumoto, David; Yoo, Seung Hee; Nakagawa, Sanae

    2008-06-01

    This article reports differences across 23 countries on 2 processes of emotion regulation--reappraisal and suppression. Cultural dimensions were correlated with country means on both and the relationship between them. Cultures that emphasized the maintenance of social order--that is, those that were long-term oriented and valued embeddedness and hierarchy--tended to have higher scores on suppression, and reappraisal and suppression tended to be positively correlated. In contrast, cultures that minimized the maintenance of social order and valued individual Affective Autonomy and Egalitarianism tended to have lower scores on Suppression, and Reappraisal and Suppression tended to be negatively correlated. Moreover, country-level emotion regulation was significantly correlated with country-level indices of both positive and negative adjustment. PMID:18505309

  8. Control of Adjustable Compliant Actuators

    Berno J.E. Misgeld

    2014-05-01

    Full Text Available Adjustable compliance or variable stiffness actuators comprise an additional element to elastically decouple the actuator from the load and are increasingly applied to human-centered robotic systems. The advantages of such actuators are of paramount importance in rehabilitation robotics, where requirements demand safe interaction between the therapy system and the patient. Compliant actuator systems enable the minimization of large contact forces arising, for example, from muscular spasticity and have the ability to periodically store and release energy in cyclic movements. In order to overcome the loss of bandwidth introduced by the elastic element and to guarantee a higher range in force/torque generation, new actuator designs consider variable or nonlinear stiffness elements, respectively. These components cannot only be adapted to the walking speed or the patient condition, but also entail additional challenges for feedback control. This paper introduces a novel design method for an impedance-based controller that fulfills the control objectives and compares the performance and robustness to a classical cascaded control approach. The new procedure is developed using a non-standard positive-real Η2 controller design and is applied to a loop-shaping approach. Robust norm optimal controllers are designed with regard to the passivity of the actuator load-impedance transfer function and the servo control problem. Classical cascaded and positive-real Η2 controller designs are validated and compared in simulations and in a test bench using a passive elastic element of varying stiffness.

  9. Exploration adjustment by ant colonies.

    Doran, Carolina; Stumpe, Martin C; Sendova-Franks, Ana; Franks, Nigel R

    2016-01-01

    How do animals in groups organize their work? Division of labour, i.e. the process by which individuals within a group choose which tasks to perform, has been extensively studied in social insects. Variability among individuals within a colony seems to underpin both the decision over which tasks to perform and the amount of effort to invest in a task. Studies have focused mainly on discrete tasks, i.e. tasks with a recognizable end. Here, we study the distribution of effort in nest seeking, in the absence of new nest sites. Hence, this task is open-ended and individuals have to decide when to stop searching, even though the task has not been completed. We show that collective search effort declines when colonies inhabit better homes, as a consequence of a reduction in the number of bouts (exploratory events). Furthermore, we show an increase in bout exploration time and a decrease in bout instantaneous speed for colonies inhabiting better homes. The effect of treatment on bout effort is very small; however, we suggest that the organization of work performed within nest searching is achieved both by a process of self-selection of the most hard-working ants and individual effort adjustment. PMID:26909180

  10. Efficient Adjustable Reflectivity Smart Window

    D. Morgan Tench

    2005-12-01

    This project addressed the key technical issues for development of an efficient smart window based on reversible electrochemical transfer of silver between a mirror electrode and a localized counter electrode. Effort to provide uniform switching over large areas focused on use of a resistive transparent electrode innerlayer to increase the interelectrode resistance. An effective edge seal was developed in collaboration with adhesive suppliers and an electrochromic device manufacturer. Work to provide a manufacturable counter electrode focused on fabricating a dot matrix electrode without photolithography by electrodeposition of Pt nuclei on inherent active sites on a transparent oxide conductor. An alternative counter electrode based on a conducting polymer and an ionic liquid electrolyte was also investigated. Work in all of these areas was successful. Sputtered large-bandgap oxide innerlayers sandwiched between conductive indium tin oxide (ITO) layers were shown to provide sufficient cross-layer resistance (>300 ohm/cm{sup 2}) without significantly affecting the electrochemical properties of the ITO overlayer. Two edge seal epoxies, one procured from an epoxy manufacturer and one provided by an electrochromic device manufacturer in finished seals, were shown to be effective barriers against oxygen intrusion up to 80 C. The optimum density of nuclei for the dot matrix counter electrode was attained without use of photolithography by electrodeposition from a commercial alkaline platinum plating bath. Silver loss issues for cells with dot matrix electrodes were successfully addressed by purifying the electrolyte and adjusting the cell cycling parameters. More than 30K cycles were demonstrated for a REM cell (30-cm square) with a dot matrix counter electrode. Larger cells (30-cm square) were successfully fabricated but could not be cycled since the nucleation layers (provided by an outside supplier) were defective so that mirror deposits could not be produced.

  11. Trade Liberalization and Trade Adjustment Assistance

    Fung, K. C.; Staiger, Robert W.

    1994-01-01

    We explore the relationship between trade adjustment subsidies and successful reciprocal trade liberalization. We consider economies that are faced with a periodic need to move resources out of a declining import-competing sector, and that are attempting to sustain cooperative but self-enforcing trade agreements in the face of these adjustment needs. If the limitations associated with enforcement of international trade agreements are sufficiently severe, trade adjustment assistance can facili...

  12. Asian immigrant settlement and adjustment in Australia.

    Khoo, S; Kee, P; Dang, T; Shu, J

    1994-01-01

    "This article provides a broad assessment of the settlement and adjustment of people born in the many countries of Asia who are resident in Australia, based on recently available data from the 1991 Census of Population and Housing. It examines some indicators of economic adjustment such as performance in the labor market, and some indicators of social adjustment, such as acquisition of English language proficiency." PMID:12289777

  13. Attitude-adjusting table for neutron monochromator

    The neutron monochromator attitude-adjusting table is one of the mechanical components for most monochromatic neutron scattering spectrometer. It is mainly used for mounting crystal monochromator, and getting monochromatic neutron by adjusting the attitude of monochromator remotely. The table has a compact volume and five adjusting axes with high resolution. It combines optic mechanical electronic technique with computer control technique. This device will be applied to the neutron residual stress spectrometer on CARR firstly. (authors)

  14. Implementation of Risk Adjustment for Medicare

    Ingber, Melvin J.

    2000-01-01

    The Health Care Financing Administration (HCFA) implemented risk adjustment for Medicare capitated organizations January 2000. The risk adjustment system used, the Principal Inpatient Diagnostic Cost Group (PIPDCG) method, had to be incorporated into the payment structure mandated by the Balanced Budget Act of 1997 (BBA). This article describes how risk adjustment was integrated into the payment system within the rules of the BBA, and how fee-for-service (FFS) and health maintenance organizat...

  15. An adjustment cost model of distributional dynamics.

    Getachew, Yoseph; Basu, Parantap

    2012-01-01

    We analyze the distributional e¤ects of adjustment cost in an environment with incomplete capital market. We find that a higher adjustment cost for human capital acquisition slows down the intergenerational mobility and results in a persistent inequality across generations. A low depreciation cost of human capital contributes to longer life of the capital which could elevate this adjustment cost and hence contribute to this inequality persistence. A lower total factor productivity could hurt...

  16. Precision Adjustable Liquid Regulator (ALR)

    Meinhold, R.; Parker, M.

    2004-10-01

    A passive mechanical regulator has been developed for the control of fuel or oxidizer flow to a 450N class bipropellant engine for use on commercial and interplanetary spacecraft. There are several potential benefits to the propulsion system, depending on mission requirements and spacecraft design. This system design enables more precise control of main engine mixture ratio and inlet pressure, and simplifies the pressurization system by transferring the function of main engine flow rate control from the pressurization/propellant tank assemblies, to a single component, the ALR. This design can also reduce the thermal control requirements on the propellant tanks, avoid costly Qualification testing of biprop engines for missions with more stringent requirements, and reduce the overall propulsion system mass and power usage. In order to realize these benefits, the ALR must meet stringent design requirements. The main advantage of this regulator over other units available in the market is that it can regulate about its nominal set point to within +/-0.85%, and change its regulation set point in flight +/-4% about that nominal point. The set point change is handled actively via a stepper motor driven actuator, which converts rotary into linear motion to affect the spring preload acting on the regulator. Once adjusted to a particular set point, the actuator remains in its final position unpowered, and the regulator passively maintains outlet pressure. The very precise outlet regulation pressure is possible due to new technology developed by Moog, Inc. which reduces typical regulator mechanical hysteresis to near zero. The ALR requirements specified an outlet pressure set point range from 225 to 255 psi, and equivalent water flow rates required were in the 0.17 lb/sec range. The regulation output pressure is maintained at +/-2 psi about the set point from a P (delta or differential pressure) of 20 to over 100 psid. Maximum upstream system pressure was specified at 320 psi

  17. Ratios as a size adjustment in morphometrics.

    Albrecht, G H; Gelvin, B R; Hartman, S E

    1993-08-01

    Simple ratios in which a measurement variable is divided by a size variable are commonly used but known to be inadequate for eliminating size correlations from morphometric data. Deficiencies in the simple ratio can be alleviated by incorporating regression coefficients describing the bivariate relationship between the measurement and size variables. Recommendations have included: 1) subtracting the regression intercept to force the bivariate relationship through the origin (intercept-adjusted ratios); 2) exponentiating either the measurement or the size variable using an allometry coefficient to achieve linearity (allometrically adjusted ratios); or 3) both subtracting the intercept and exponentiating (fully adjusted ratios). These three strategies for deriving size-adjusted ratios imply different data models for describing the bivariate relationship between the measurement and size variables (i.e., the linear, simple allometric, and full allometric models, respectively). Algebraic rearrangement of the equation associated with each data model leads to a correctly formulated adjusted ratio whose expected value is constant (i.e., size correlation is eliminated). Alternatively, simple algebra can be used to derive an expected value function for assessing whether any proposed ratio formula is effective in eliminating size correlations. Some published ratio adjustments were incorrectly formulated as indicated by expected values that remain a function of size after ratio transformation. Regression coefficients incorporated into adjusted ratios must be estimated using least-squares regression of the measurement variable on the size variable. Use of parameters estimated by any other regression technique (e.g., major axis or reduced major axis) results in residual correlations between size and the adjusted measurement variable. Correctly formulated adjusted ratios, whose parameters are estimated by least-squares methods, do control for size correlations. The size-adjusted

  18. 75 FR 59684 - Trade Adjustment Assistance for Farmers

    2010-09-28

    ... Foreign Agricultural Service Trade Adjustment Assistance for Farmers AGENCY: Foreign Agricultural Service... analyzed by USDA's Economic Research Service and reviewed by the Trade Adjustment Assistance for Farmers... adjustment assistance in FY 2011. FOR FURTHER INFORMATION CONTACT: Trade Adjustment Assistance for...

  19. Adjustment of the Internal Tax Scale

    2013-01-01

    In application of Article R V 2.03 of the Staff Regulations, the internal tax scale has been adjusted with effect on 1 January 2012. The new scale may be consulted via the CERN Admin e-guide.  The notification of internal annual tax certificate for the financial year 2012 takes into account this adjustment. HR Department (Tel. 73907)

  20. Ergonomically Adjustable School Furniture for Male Students

    Al-Saleh, Khalid S.; Ramadan, Mohamed Z.; Al-Ashaikh, Riyad A.

    2013-01-01

    The need for adjustability in school furniture, in order to accommodate the variation in anthropometric measures of different genders, cultures and ages is becoming increasingly important. Four chair-table combinations, different in dimensions, with adjustable chair seating heights and table heights were designed, manufactured and distributed to…

  1. Adjustment Policies in the United States

    Blandford, David

    2003-01-01

    Principal adjustment programs are reviewed unemployment insurance (UI) and related long-term programs for displaced workers, and trade adjustment assistance (TAA). None of these programs has had wide application in agriculture, although the current trade act contains a new program specifically for farmers.

  2. 24 CFR 886.112 - Rent adjustments.

    2010-04-01

    ... Adjustment Factor most recently published by HUD in the Federal Register in accordance with 24 CFR part 888... unassisted housing in the area to ensure that adjustments in the Contract Rents shall not result in material differences between the rents charged for assisted and comparable unassisted units. Contract Rents may...

  3. A Digital Game for International Students' Adjustment

    Bisadi, Maryam; Chua, Alton Y. K; Keong, Lee Chu

    2013-01-01

    Although digital games have been developed for various subject areas, little attention has been focused on using digital games to address international students' adjustment issues. For this reason, this paper endeavors to explore the use of a digital game in facilitating international students acquire adjustment-related information. Specifically,…

  4. 10 CFR 905.34 - Adjustment provisions.

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Adjustment provisions. 905.34 Section 905.34 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Power Marketing Initiative § 905.34 Adjustment... continue to take place based on existing contract/marketing criteria principles....

  5. Psychological Separation and Adjustment to College.

    Lapsley, Daniel K.; And Others

    1989-01-01

    Examined relationship between psychological separation and adjustment to college in freshmen (N=130) and upperclassmen (N=123). Found freshmen showed more psychological dependencies on parents than upperclassmen; separation appeared more strongly related to personal/emotional adjustment, particularly functional and emotional independence from…

  6. 34 CFR 36.2 - Penalty adjustment.

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Penalty adjustment. 36.2 Section 36.2 Education Office of the Secretary, Department of Education ADJUSTMENT OF CIVIL MONETARY PENALTIES FOR INFLATION § 36.2... applicable) penalty amount 20 U.S.C. 1015(c)(5) Provides for a fine of up to $25,000 for failure by...

  7. Attachment for sucker rod depth adjustment

    Collins, N.D.

    1992-04-07

    This patent describes a surface unit of an oil well pumping system, having a walking beam, a suspended carrier bar and an interconnected sucker rod assembly for stroking a reciprocating down-hole pump. It comprises a cross bar having a centrally located passage therein for the sucker rod assembly and adapted to be transversely supported by the carrier bar; a depth adjusting bar, having a centrally located passage therein for the sucker rod assembly, positioned at a selected fixed dimension above and parallel to the cross bar and adapted to operatively support the sucker rod assembly; clamping means for fixing the sucker rod relative to the depth adjusting bar; and hydraulically extendable means supportively connecting the depth adjusting bar to the cross bar on at least each side of the carrier bar for adjusting the selected fixed dimension and maintaining the adjustment during operation.

  8. Cultural Distance Asymmetry in Expatriate Adjustment

    Selmer, Jan; Chiu, Randy K.; Shenkar, Oded

    2007-01-01

    the assignment. Design/methodology/approach - Using a two-flow sample of US expatriates in Germany and German expatriates in the USA, we examine and compare the psychological and socio-cultural adjustment of each group of executives. Findings - Controlling for the length of assignment, we find that...... German expatriates in the USA were better adjusted, both socio-culturally and psychologically, than American expatriates in Germany. These results support the asymmetry hypothesis and call into question previous findings attesting to the relationship between CD and expatriate adjustment. Originality......Purpose - The current literature implicitly assumes a symmetric impact of cultural distance (CD) on expatriate adjustment. By using distance as a predictor of adjustment, the literature has rendered the direction of the flow irrelevant: a US expatriate in Germany is presumed to face the same hurdle...

  9. Vocational and social adjustment after laryngectomy.

    Goldberg, R T

    1975-01-01

    This study examined the vocational and social adjustment of 62 persons with cancer of the larynx. Predisability data were obtained by interview on 14 measures which assessed the vocational, social, and home adjustment prior to cancer. Post-disability data were obtained after laryngectomy by interview on 21 measures of adjustment. Additional measures include severity of laryngeal cancer classified by clinival stages, total or partial laryngectomy, presence of radiation therapy, presence of speech, months since surgery, age, sex, education, and marital status. The best predictors of vocational and social adjustment after laryngectomy were: removation, realism, rehabiltation outlook, previous vocational plans, highest educational grade, educational plans, and acquisition of speech. There were no significant differences in adjustment among patients in different clinical stages. PMID:1135615

  10. Cross-Cultural Adjustment of Chinese Students in Japan: School Adjustment and Educational Support

    Li, Yuan Xiang; Sano, Hideki; Ahn, Ruth

    2013-01-01

    This study investigates Chinese immigrant students' cross-cultural and school adjustment issues in Japanese schools. Using a quantitative method, a survey which collected students' demographic information, cross-cultural adjustment, and school adjustment questions was administered to 143 Chinese junior high and high school students in…

  11. Role of Osmotic Adjustment in Plant Productivity

    Gebre, G.M.

    2001-01-11

    Successful implementation of short rotation woody crops requires that the selected species and clones be productive, drought tolerant, and pest resistant. Since water is one of the major limiting factors in poplar (Populus sp.) growth, there is little debate for the need of drought tolerant clones, except on the wettest of sites (e.g., lower Columbia River delta). Whether drought tolerance is compatible with productivity remains a debatable issue. Among the many mechanisms of drought tolerance, dehydration postponement involves the maintenance of high leaf water potential due to, for example, an adequate root system. This trait is compatible with productivity, but requires available soil moisture. When the plant leaf water potential and soil water content decline, the plant must be able to survive drought through dehydration tolerance mechanisms, such as low osmotic potential or osmotic adjustment. Osmotic adjustment and low osmotic potential are considered compatible with growth and yield because they aid in the maintenance of leaf turgor. However, it has been shown that turgor alone does not regulate cell expansion or stomatal conductance and, therefore, the role of osmotic adjustment is debated. Despite this finding, osmotic adjustment has been correlated with grain yield in agronomic crop species, and gene markers responsible for osmotic adjustment are being investigated to improve drought tolerance in productive progenies. Although osmotic adjustment and low osmotic potentials have been investigated in several forest tree species, few studies have investigated the relationship between osmotic adjustment and growth. Most of these studies have been limited to greenhouse or container-grown plants. Osmotic adjustment and rapid growth have been specifically associated in Populus and black spruce (Picea mariuna (Mill.) B.S.P.) progenies. We tested whether these relationships held under field conditions using several poplar clones. In a study of two hybrid poplar

  12. Experiment on performance of adjustable jet pump

    When the water level of upper or lower reaches of hydraulic power station changes, the adjustable jet pump which is different from traditional fixed jet pump can maintain stable pressure and flow rate for the system of technical water supply of hydraulic power plant. The model test indicates that the efficiency of the adjustable jet pump is slightly lower than fixed jet pump near rating operation point. With the decrease of opening degree, both efficiencies are more and more close to each other. The fundamental performance of I-type adjustable jet pump is better than II-type and the cavitation performance of I-type adjustable jet pump is worse than II-type. Test data also indicate that the performance of adjustable jet pump is very different from fixed jet pump, so the theory of fixed jet pump is not able to be copied to adjustable jet pump. It is necessary to farther study on the performance of the adjustable jet pump. This paper has reference value for analogous design of system of circulation water supply to turbine units in hydraulic power station.

  13. Adjustment and mental health problem in prisoners

    Sudhinta Sinha

    2010-01-01

    Full Text Available Background : "Crime" is increasing day by day in our society not only in India but also all over the world. In turn, the number of prisoners is also increasing at the same rate. They remain imprisoned for a long duration or in some cases for the whole life. Living in a prison for long time becomes difficult for all inmates. So they often face adjustment and mental health problems. Recent findings suggest that mental illness rate in prison is three times higher than in the general population. Objective: The aim of the present study was to investigate the adjustment and the mental health problem and its relation in the prisoners. Materials and Methods : In the present study, 37 male prisoners of district jail of Dhanbad District of Jharkhand were selected on purposive sampling basis. Each prisoner was given specially designed Performa - Personal Data Sheet, General Health Questionnaire-12 and Bell Adjustment Inventory. Appropriate statistical tools were used to analyze the data. Results: The results obtained showed poor adjustment in social and emotional areas on the adjustment scale. The study also revealed a significant association between adjustment and mental health problem in the prisoners. Conclusion: The prisoners were found to have poor social and emotional adjustment which has strong association with their mental health.

  14. Experiment on performance of adjustable jet pump

    Zhu, J. M.; Long, X. P.; Zhang, S. B.; Lu, X.

    2012-11-01

    When the water level of upper or lower reaches of hydraulic power station changes, the adjustable jet pump which is different from traditional fixed jet pump can maintain stable pressure and flow rate for the system of technical water supply of hydraulic power plant. The model test indicates that the efficiency of the adjustable jet pump is slightly lower than fixed jet pump near rating operation point. With the decrease of opening degree, both efficiencies are more and more close to each other. The fundamental performance of I-type adjustable jet pump is better than II-type and the cavitation performance of I-type adjustable jet pump is worse than II-type. Test data also indicate that the performance of adjustable jet pump is very different from fixed jet pump, so the theory of fixed jet pump is not able to be copied to adjustable jet pump. It is necessary to farther study on the performance of the adjustable jet pump. This paper has reference value for analogous design of system of circulation water supply to turbine units in hydraulic power station.

  15. Adjustment as process and outcome: Measuring adjustment to HIV in Uganda.

    Martin, Faith; Russell, Steve; Seeley, Janet

    2016-05-01

    'Adjustment' in health refers to both processes and outcomes. Its measurement and conceptualisation in African cultures is limited. In total, 263 people living with HIV and receiving anti-retroviral therapy in clinics in Uganda completed a translated Mental Adjustment to HIV Scale, depression items from the Hopkins checklist and demographic questions. Factor analysis revealed four Mental Adjustment to HIV factors of active coping, cognitive-social adjustment, hopelessness and denial/avoidance. Correlations with depression supported the Mental Adjustment to HIV's validity and the importance of active adjustment, while the role of cognitive adjustment was unclear. Factors were process or outcome focussed, suggesting a need for theory-based measures in general. PMID:25030794

  16. Fibrin-related markers for diagnosing acute-, subclinical-, and pre-venous thromboembolism in patients with major orthopedic surgery.

    Yamaguchi, Toshio; Wada, Hideo; Miyazaki, Shinichi; Hasegawa, Masahiro; Wakabayashi, Hiroki; Asanuma, Kunihiro; Fujimoto, Naoki; Matsumoto, Takeshi; Ohishi, Kohshi; Sakaguchi, Akane; Yamada, Norikazu; Ito, Masaaki; Yamashita, Yoshiki; Katayama, Naoyuki; Sudo, Akihiro

    2016-05-01

    Venous thromboembolism (VTE) is a common complication in patients who have undergone major orthopedic surgery, but there are few predictors of VTE after major orthopedic surgery treated with an anticoagulant. We measured levels of fibrin-related markers (FRMs), such as D-dimer, soluble fibrin (SF), and fibrinogen and fibrin degradation products (FDPs) in 66 patients with acute-phase VTE, and 367 patients undergoing major orthopedic surgery. Plasma FDP, D-dimer, and SF levels were significantly higher in patients with acute VTE, but only FDP and D-dimer levels were significantly higher in subclinical VTE. Adequate cut-off levels of D-dimer were 2.2 μg/ml for diagnosing acute VTE and 1.5 μg/ml for diagnosing subclinical VTE. D-dimer of less than 1.9 or 0.7 μg/ml ruled out acute VTE or subclinical VTE. D-dimer of more than 1.3 μg/ml preoperatively showed a moderate risk for postoperative VTE. Measurement of FRMs is useful for evaluating the risk of subclinical or postoperative VTE in patients with major orthopedic surgery. In particular, FDP is the most valuable marker for diagnosing acute VTE, whereas D-dimer is the most valuable for diagnosing subclinical VTE or predicting VTE. PMID:26872909

  17. Price adjustments by a gasoline retail chain

    We use daily data to examine price responses in the Swedish gasoline market to changes in the Rotterdam spot price, exchange rates and taxes. The distribution of price adjustments by a leading retail chain, for the period January 1980 to December 1996, is symmetric with no small adjustments. An error correction model shows that, in the short run, prices gradually move towards the long-run equilibrium in response to cost shocks. There is some evidence that, also in the short run, prices are stickier downwards than upwards. Prices respond more rapidly to exchange rate movements than to the spot market price. Our analysis emphasizes that to fully understand price adjustments it is necessary to examine data sets where the sample frequency at least matches that of price adjustments

  18. Annual adjustments to 2015 financial benefits

    HR Department

    2015-01-01

    In accordance with recommendations made by the Finance Committee and decisions taken by Council in December 2014, no adjustments have been made to basic salaries and stipends, subsistence allowances or family benefits as at 1 January 2015.

  19. Annual adjustments to 2016 financial benefits

    HR Department

    2016-01-01

    In accordance with recommendations made by the Finance Committee and decisions taken by the Council in December 2015, no adjustments have been made to basic salaries and stipends, subsistence allowances or family benefits as at 1 January 2016.  

  20. A neutron collimator with adjustable radiation field

    An adjustable neutron collimator for neutron therapy purposes is described. The collimator is designed to give a very sharp radiation field and a high freedom of choice for the radiation geometrics. (L.E.)

  1. Overpaying morbidity adjusters in risk equalization models.

    van Kleef, R C; van Vliet, R C J A; van de Ven, W P M M

    2016-09-01

    Most competitive social health insurance markets include risk equalization to compensate insurers for predictable variation in healthcare expenses. Empirical literature shows that even the most sophisticated risk equalization models-with advanced morbidity adjusters-substantially undercompensate insurers for selected groups of high-risk individuals. In the presence of premium regulation, these undercompensations confront consumers and insurers with incentives for risk selection. An important reason for the undercompensations is that not all information with predictive value regarding healthcare expenses is appropriate for use as a morbidity adjuster. To reduce incentives for selection regarding specific groups we propose overpaying morbidity adjusters that are already included in the risk equalization model. This paper illustrates the idea of overpaying by merging data on morbidity adjusters and healthcare expenses with health survey information, and derives three preconditions for meaningful application. Given these preconditions, we think overpaying may be particularly useful for pharmacy-based cost groups. PMID:26420555

  2. Continuity Adjustment for Control Charts for Attributes

    L.K. Chan; T.K. Mak; B. Tao

    2003-01-01

    A unified approach is proposed for making a continuity adjustment on some control charts for attributes, e.g., np-chart and c-chart, through adding a uniform (0, 1) random observation to the conventional sample statistic (e.g., npi and ci). The adjusted sample statistic then has a continuous distribution. Consequently, given any Type I risk α (the probability that the sample statistic is on or beyond the control limits),control charts achieving the exact value of α can be readily constructed. Guidelines are given for when to use the continuity adjustment control chart, the conventional Shewhart control chart (with ±3 standard deviations control limits), and the control chart based on the exact distribution of the sample statistic before adjustment.

  3. Vietnamese Amerasians: Psychosocial Adjustment and Psychotherapy.

    Bemak, Fred; Chung, Rita Chi-Ying

    1997-01-01

    Reviews the literature on Amerasians and offers suggestions for directions in psychotherapy. Provides a brief chronology of Amerasian emigration and associated psychological issues, followed by a discussion of myths and generalizations about Amerasians, research findings, and adjustment issues. (RJM)

  4. Determinants of intercultural adjustment among expatriate spouses

    Ali, Anees; Van der Zee, K.I.; Sanders, G

    2003-01-01

    The adaptation of expatriate families to a host country seems crucial to successful fulfilment of international business assignments. The present study focused on personality, family characteristics and characteristics of expatriates' work life as determinants of the intercultural adjustment of expa

  5. 76 FR 67500 - Postal Service Price Adjustment

    2011-11-01

    ... asserts that it expects this to improve the cost coverage for the parcels that remain in the market... product profitability. Id. The Postal Service characterizes the adjustment for Single-Piece Parcel Post...

  6. Annual adjustments to 2013 financial benefits

    2013-01-01

    In accordance with recommendations made by the Finance Committee and decisions taken by Council in December 2012, no adjustments have been made to basic salaries and stipends, subsistence allowances or family benefits as at 1 January 2013. HR Department

  7. Annual adjustments to 2014 financial benefits

    2013-01-01

    In accordance with recommendations made by the Finance Committee and decisions taken by Council in December 2013, no adjustments have been made to basic salaries and stipends, subsistence allowances or family benefits as at 1 January 2014. HR Department

  8. Speed of adjustment: Evidence from Borsa Istanbul

    Emrah Arioglu

    2014-06-01

    Full Text Available In this study, we investigate the speed of adjustment for leverage ratios of firms listed on Borsa Istanbul, in order to investigate the prediction of the trade-off theory, regarding capital structure rebalancing. For this purpose, we estimate the speed of adjustment by using Generalized Method of Moments system estimation technique. The results of this estimation suggest the speed of adjustment as approximately 29%. This significant speed of adjustment is consistent with the prediction of trade-off theory, which suggests that firms follow target capital structures and when the firms' leverage ratios deviate from these targets; they make financial decisions with the goal of closing the gap between the previous year's leverage and target leverage of the current period.

  9. Dinamika Personal Adjustment Pada Mantan PSK

    Ginting, Reza Yoga Pratama

    2014-01-01

    The research uses qualitative approach and aims to find the personal adjustment dynamic of former sexual worker. This research uses two respondents living in Medan and Pematang Siantar. The procedure of selecting the respondent was snowball method. The data were obtain by conducting interview. Theory that has been used in this research is personal adjustment theory by Weiten & Lyoid (2006) that consist of three aspects: stress and coping stress, interpersonal realm, and developmental transiti...

  10. Industrial Forecasts after Export Rebates Adjustment

    2007-01-01

    @@ On June 19, 2007, the Circular of the Ministry of Finance and the State Administration of Taxation concerning Lowering the Export Rebate Rates for Some Commodities was published, which finally proved the early rumor of tax rebate adjustment to be true.According to the Circular, the export rebate rates for some commodities have been adjusted upon approval of the State Council and the new rates have become in force since July 1, 2007.

  11. Adjustable Fiber Optic Microwave Transversal Filters

    Shadaram, Mehdi; Lutes, George F.; Logan, Ronald T.; Maleki, Lutfollah

    1994-01-01

    Microwave transversal filters implemented as adjustable tapped fiber optic delay lines developed. Main advantages of these filters (in comparison with conventional microwave transversal filters) are small size, light weight, no need for matching of radio-frequency impedances, no need for shielding against electromagnetic radiation at suboptical frequencies, no need for mechanical tuning, high stability of amplitude and phase, and active control of transfer functions. Weights of taps in fiber optic delay lines adjusted.

  12. Risk adjusted equity valuation and accounting betas

    Pope, P F; Wang, P.

    2000-01-01

    In this paper we develop a general equity valuation model where abnormal earnings, back value, the discount factor and interest rates evolve stochastically. Focusing on the dynamics of abnormal earnings, we demonstrate the back value, abnormal earnings, "other information" and two risk adjustment terms are sufficient for valuation when pricing kernel risk is attributable to a single market factor. The risk adjustment terms depend on accounting betas reflecting the covariances between abnormal...

  13. Adjustable Powder Injector For Vacuum Plasma Sprayer

    Burns, D. H.; Woodford, W. H.; Mckechnie, T. N.; Mcferrin, D. C.; Davis, W. M.; Beason, G. P., Jr.

    1993-01-01

    Attachment for plasma spray gun provides four degrees of freedom for adjustment of position and orientation at which powder injected externally into plasma flame. Manipulator provides for adjustment of pitch angle of injection tube: set to inject powder at any angle ranging from perpendicular to parallel to cylindrical axis. Scribed lines on extension bar and manipulator indicate pitch angle of extension tube. Collar changed to adapt injector to different gun.

  14. An Adjustment Restriction on Fish Quota

    van Dijk; Hendrix, E.M.T.; Haijema, Rene; Groeneveld, R.A.; Ierland, van, E.C.

    2016-01-01

    Management objectives of the European Union for North Sea fish stocks are shifting towards considering both biological sustainability and economic benefits. As part of multiannual management plans, an adjustment restriction on fish quota has been introduced. Its objective is to obtain an efficient fish stock and to reduce overcapacity for the fishing industry. We develop and apply a bi-level stochastic dynamic programming model to study the effect of a quota adjustment restriction on the net ...

  15. Capital Asset Pricing Model Adjusted for Anchoring

    Hammad, Siddiqi

    2015-01-01

    I show that adjusting CAPM for anchoring provides a unified explanation for the size, value, and momentum effects. Anchoring adjusted CAPM (ACAPM) predicts that stock splits are associated with positive abnormal returns and an increase in return volatility, whereas the reverse stock-splits are associated with negative abnormal returns and a fall in return volatility. Existing empirical evidence strongly supports these predictions. Anchoring has the effect of pushing up the equity premium, a ...

  16. Predicting Eating Disorder Continuum Groups: Hardiness and College Adjustment.

    Simon-Boyd, Gail D.; Bieschke, Kathleen J.

    This study examined relationships between hardiness, college adjustment (academic adjustment, social adjustment, personal-emotional adjustment, institutional attachment) and eating disorder (ED) continuum categories in 122 female and 20 male college students. Students who exhibited a higher level of personal-emotional adjustment (PEA) to college…

  17. Energetics of geostrophic adjustment in rotating flow

    Juan, Fang; Rongsheng, Wu

    2002-09-01

    Energetics of geostrophic adjustment in rotating flow is examined in detail with a linear shallow water model. The initial unbalanced flow considered first falls tinder two classes. The first is similar to that adopted by Gill and is here referred to as a mass imbalance model, for the flow is initially motionless but with a sea surface displacement. The other is the same as that considered by Rossby and is referred to as a momentum imbalance model since there is only a velocity perturbation in the initial field. The significant feature of the energetics of geostrophic adjustment for the above two extreme models is that although the energy conversion ratio has a large case-to-case variability for different initial conditions, its value is bounded below by 0 and above by 1 / 2. Based on the discussion of the above extreme models, the energetics of adjustment for an arbitrary initial condition is investigated. It is found that the characteristics of the energetics of geostrophic adjustment mentioned above are also applicable to adjustment of the general unbalanced flow under the condition that the energy conversion ratio is redefined as the conversion ratio between the change of kinetic energy and potential energy of the deviational fields.

  18. 75 FR 59681 - Trade Adjustment Assistance for Farmers

    2010-09-28

    ... Foreign Agricultural Service Trade Adjustment Assistance for Farmers AGENCY: Foreign Agricultural Service... Farmers Program Review Committee, comprised of representatives from USDA's Office of the Chief Economist... adjustment assistance in FY 2011. FOR FURTHER INFORMATION CONTACT: Trade Adjustment Assistance for...

  19. 75 FR 16575 - Railroad Cost Recovery Procedures-Productivity Adjustment

    2010-04-01

    ... Surface Transportation Board Railroad Cost Recovery Procedures--Productivity Adjustment AGENCY: Surface Transportation Board. ACTION: Adoption of a railroad cost recovery procedures productivity adjustment. SUMMARY... productivity adjustment, as measured by the average change in railroad productivity for the years 2004...

  20. 26 CFR 1.803-2 - Adjusted reserves.

    2010-04-01

    ...) INCOME TAXES Life Insurance Companies § 1.803-2 Adjusted reserves. For the purpose of determining... insurance, no adjustment is to be made. The reserves are thus adjusted, and the rate of interest on...