sup(99m)TcO4- and 67Ga-citrate scintigraphies were applied to 114 cases of parotid tumor patient. Diagnostic evaluation of these methods was estimated especially from the viewpoint of preoperative malignancy grading, comparing with their clinical figures and histopathological findings. In sup(99m)TcO4- scintigram, parotid neoplasms often showed focal defect (81%). Otherwise, adenolymphoma actively accumulated sup(99m)TcO4- nearly two third cases. Only mature typed adenolymphoma which comprised macroscopic follicular cyst, sometimes presented focal defect. Well differentiated type of mucoepidermoid tumors hardly presented different images from contralateral parotid glands. In 67Ga-citrate scintigram, benign neoplasms showed symmetrial or focally defective appearances (72%). On the contrally, high grade malignant tumors indicated high incidence of focal hot nodule (75%). Low grade malignancy tumors, which comprise acinic cell tumor and well differenciated mucoepidermoid tumor, also showed focal hot scintigram or diffuse increased uptake in high rate (92%). This study proved that sup(99m)TcO4- and 67Ga-citrate scintigraphies are sufficiently useful to diagnose parotid tumor malignancy in advance to surgical operation. (author)
Full Text Available Significant differences in the global distribution of salivary gland tumors have been reported, but no formal study has been carried out here in Kano, the largest city in northern Nigeria. We therefore undertook this eight-year retrospective study of all histologically diagnosed salivary neoplasms at the histopathology laboratory of our referral teaching hospital in Kano. Seventy-eight salivary gland tumors were diagnosed during the eight-year study period accounting for 0.4% of all neoplasms. Benign tumors were more prevalent, comprising 56.4%, while malignancies were 43.6%. Pleomorphic adenoma and mucoepidermoid carcinoma were the commonest histological types constituting 48.7% and 23.1% respectively, while the most frequent sites were parotid, submandibular and minor salivary glands accounting for 49%, 26% and 24% respectively. As in most studies of black populations there were no adenolymphomas. Age distribution was bimodal with a benign peak in the third decade and a malignant peak in the sixth. Our findings were broadly similar to most other African reports but somewhat at variance with Western literature. Improved hospital attendance with more comprehensive reporting would yield more representative data.
Introduction. - Localized melanoma is a potentially aggressive tumor. Its prognosis depends mainly on pathologic factors, namely: thickness (Breslow index), presence of ulceration and microscopic nodal metastasis. FDG PET is the modality of choice for evaluation of advanced melanoma and has proven its superiority in terms of sensitivity, specificity and accuracy compared to conventional imaging. Early stages of melanoma do not seem to benefit from PET FDG. However the value of PET FDG in staging localized high risk melanoma is yet to be determined. Patients and methods. - We have evaluated 87 patients with high risk melanoma with PET FDG. 32 patients presented with a Breslow index superior or equal to 4 mm, 21 with a Breslow index inferior to 4 mm and ulceration and 34 with a positive sentinel lymphadenectomy. PET FDG was realized after at least 6 h of fasting on a hybrid PET-CT G.E. Discovery S.T. scan for 65 of them. The rest of the patients were evaluated on a Siemens Ecat H.R. + scan. Scans were interpreted by an experimented nuclear medicine physician and were classified as positive or negative. All equivocal scans or cases for which there was discordance between the scan result and follow up were reviewed by 2 experimented nuclear medicine physicians and a consensus was reached. Results. - FDG PET was positive in seven patients, four scans were true positive and identified regional metastatic disease. No distant metastatic visceral disease was found. The three false positive scans consisted of a cyst adeno-lymphoma in one case, mediastinal and axillary uptake in the other two cases and no sign of evolution more than six months after the scan. Four patients with a negative scan showed metastatic disease in the six months following the PET scan. FDG PET had an impact on therapeutic management on two patients (2%). When evaluating FDG PET for regional disease with sentinel node biopsy as a reference, we found values of sensitivity, specificity, predictive
Haiquan Yao; Hongping Lin; Peng Zhang; Tao Zhang; Libo Feng
Objective: The aim of the study was to investigate CT and MRI findings of parotid Warthin's tumors (parotid ad-enolymphomas). Methods: CT and MRI findings of 14 patients with pathologically-confirmed Warthin's tumor (10 males and 4 females) were retrospectively analyzed. The average age was 56 years (range 44-77 years). Twelve patients underwent CT plain scan, of which, 10 received the further enhancement; other 2 patients performed MR plain scan, of which, 1 was enhanced. The disease course ranged from 20 days to 4 years with the average of 22 months. Ten patients had the smoking history (71.4%). Results: A total of 22 foci were found in all 14 patients, multiple in one parotid gland in 3 patients, single in one parotid gland in 9 patients and single in bilateral glands in 2 patients (one recurred the tumor in the contralateral gland 14 years after the surgery). Sixteen (72.7%) foci or the main bodies [long diameter of 0.8-5.0 cm with the average of (2.3 ± 1.3) cm] were located in the posterior and interior role of the superficial lobe of the parotid gland. The foci were round or oval. The boundary was smooth in 21 (95.5%) foci and blurred in 3 foci which were proved by biopsy to be accompanied with infection. Fourteen foci (77.7%) with uniform density and 4 foci with nonuniform density were found in 12 patients under CT plain. A total of 15 foci in 10 patients were enhanced, 7 (46.7%) on significant enhancement, 5 (33.3%) on moderate enhancement and 3 on slight enhancement. The margin was enhanced slightly in 3 foci. In MR images, the signal of tumor was uniform or nonunifrom, T1WI showed low signal and T2WI showed moderate or high signal. The envelope displayed signal shadow under plain scan and the enhancement was slightly. Conclusion: For middle or elder males with the smoking history, if they have the foci in the posterior and interior parts of the parotid gland which show clear boundary and significant enhancement, especially for multiple or bilateral foci