Discounting of Monetary Rewards That Are Both Delayed and Probabilistic: Delay and Probability Combine Multiplicatively, Not Additively

Science.gov (United States)

Vanderveldt, Ariana; Green, Leonard; Myerson, Joel

2015-01-01

The value of an outcome is affected both by the delay until its receipt (delay discounting) and by the likelihood of its receipt (probability discounting). Despite being well-described by the same hyperboloid function, delay and probability discounting involve fundamentally different processes, as revealed, for example, by the differential effects…

Time Delay and Long-Range Connection Induced Synchronization Transitions in Newman-Watts Small-World Neuronal Networks

Science.gov (United States)

Qian, Yu

2014-01-01

The synchronization transitions in Newman-Watts small-world neuronal networks (SWNNs) induced by time delay and long-range connection (LRC) probability have been investigated by synchronization parameter and space-time plots. Four distinct parameter regions, that is, asynchronous region, transition region, synchronous region, and oscillatory region have been discovered at certain LRC probability as time delay is increased. Interestingly, desynchronization is observed in oscillatory region. More importantly, we consider the spatiotemporal patterns obtained in delayed Newman-Watts SWNNs are the competition results between long-range drivings (LRDs) and neighboring interactions. In addition, for moderate time delay, the synchronization of neuronal network can be enhanced remarkably by increasing LRC probability. Furthermore, lag synchronization has been found between weak synchronization and complete synchronization as LRC probability is a little less than 1.0. Finally, the two necessary conditions, moderate time delay and large numbers of LRCs, are exposed explicitly for synchronization in delayed Newman-Watts SWNNs. PMID:24810595

H∞ Control for a Networked Control Model of Systems with Two Additive Time-Varying Delays

Directory of Open Access Journals (Sweden)

Hanyong Shao

2014-01-01

Full Text Available This paper is concerned with H∞ control for a networked control model of systems with two additive time-varying delays. A new Lyapunov functional is constructed to make full use of the information of the delays, and for the derivative of the Lyapunov functional a novel technique is employed to compute a tighter upper bound, which is dependent on the two time-varying delays instead of the upper bounds of them. Then the convex polyhedron method is proposed to check the upper bound of the derivative of the Lyapunov functional. The resulting stability criteria have fewer matrix variables but less conservatism than some existing ones. The stability criteria are applied to designing a state feedback controller, which guarantees that the closed-loop system is asymptotically stable with a prescribed H∞ disturbance attenuation level. Finally examples are given to show the advantages of the stability criteria and the effectiveness of the proposed control method.

Mixed butanols addition to gasoline surrogates: Shock tube ignition delay time measurements and chemical kinetic modeling

KAUST Repository

AlRamadan, Abdullah S.; Badra, Jihad; Javed, Tamour; Alabbad, Mohammed; Bokhumseen, Nehal; Gaillard, Patrick; Babiker, Hassan; Farooq, Aamir; Sarathy, Mani

2015-01-01

work, the effect of mixed butanols addition to gasoline surrogates has been investigated in a high-pressure shock tube facility. The ignition delay times of mixed butanols stoichiometric mixtures were measured at 20 and 40bar over a temperature range

Weighted H∞ Filtering for a Class of Switched Linear Systems with Additive Time-Varying Delays

Directory of Open Access Journals (Sweden)

Li-li Li

2015-01-01

Full Text Available This paper is concerned with the problem of weighted H∞ filtering for a class of switched linear systems with two additive time-varying delays, which represent a general class of switched time-delay systems with strong practical background. Combining average dwell time (ADT technique with piecewise Lyapunov functionals, sufficient conditions are established to guarantee the exponential stability and weighted H∞ performance for the filtering error systems. The parameters of the designed switched filters are obtained by solving linear matrix inequalities (LMIs. A modification of Jensen integral inequality is exploited to derive results with less theoretical conservatism and computational complexity. Finally, two examples are given to demonstrate the effectiveness of the proposed method.

Delayed feedback control of fractional-order chaotic systems

International Nuclear Information System (INIS)

Gjurchinovski, A; Urumov, V; Sandev, T

2010-01-01

We study the possibility to stabilize unstable steady states and unstable periodic orbits in chaotic fractional-order dynamical systems by the time-delayed feedback method. By performing a linear stability analysis, we establish the parameter ranges for successful stabilization of unstable equilibria in the plane parameterized by the feedback gain and the time delay. An insight into the control mechanism is gained by analyzing the characteristic equation of the controlled system, showing that the control scheme fails to control unstable equilibria having an odd number of positive real eigenvalues. We demonstrate that the method can also stabilize unstable periodic orbits for a suitable choice of the feedback gain, providing that the time delay is chosen to coincide with the period of the target orbit. In addition, it is shown numerically that delayed feedback control with a sinusoidally modulated time delay significantly enlarges the stability region of steady states in comparison to the classical time-delayed feedback scheme with a constant delay.

Mixed butanols addition to gasoline surrogates: Shock tube ignition delay time measurements and chemical kinetic modeling

KAUST Repository

AlRamadan, Abdullah S.

2015-10-01

The demand for fuels with high anti-knock quality has historically been rising, and will continue to increase with the development of downsized and turbocharged spark-ignition engines. Butanol isomers, such as 2-butanol and tert-butanol, have high octane ratings (RON of 105 and 107, respectively), and thus mixed butanols (68.8% by volume of 2-butanol and 31.2% by volume of tert-butanol) can be added to the conventional petroleum-derived gasoline fuels to improve octane performance. In the present work, the effect of mixed butanols addition to gasoline surrogates has been investigated in a high-pressure shock tube facility. The ignition delay times of mixed butanols stoichiometric mixtures were measured at 20 and 40bar over a temperature range of 800-1200K. Next, 10vol% and 20vol% of mixed butanols (MB) were blended with two different toluene/n-heptane/iso-octane (TPRF) fuel blends having octane ratings of RON 90/MON 81.7 and RON 84.6/MON 79.3. These MB/TPRF mixtures were investigated in the shock tube conditions similar to those mentioned above. A chemical kinetic model was developed to simulate the low- and high-temperature oxidation of mixed butanols and MB/TPRF blends. The proposed model is in good agreement with the experimental data with some deviations at low temperatures. The effect of mixed butanols addition to TPRFs is marginal when examining the ignition delay times at high temperatures. However, when extended to lower temperatures (T < 850K), the model shows that the mixed butanols addition to TPRFs causes the ignition delay times to increase and hence behaves like an octane booster at engine-like conditions. © 2015 The Combustion Institute.

Combined action of time-delay and colored cross-associated multiplicative and additive noises on stability and stochastic resonance for a stochastic metapopulation system

Science.gov (United States)

Wang, Kang-Kang; Zong, De-Cai; Wang, Ya-Jun; Li, Sheng-Hong

2016-05-01

In this paper, the transition between the stable state of a big density and the extinction state and stochastic resonance (SR) for a time-delayed metapopulation system disturbed by colored cross-correlated noises are investigated. By applying the fast descent method, the small time-delay approximation and McNamara and Wiesenfeld's SR theory, we investigate the impacts of time-delay, the multiplicative, additive noises and colored cross-correlated noise on the SNR and the shift between the two states of the system. Numerical results show that the multiplicative, additive noises and time-delay can all speed up the transition from the stable state to the extinction state, while the correlation noise and its correlation time can slow down the extinction process of the population system. With respect to SNR, the multiplicative noise always weakens the SR effect, while noise correlation time plays a dual role in motivating the SR phenomenon. Meanwhile, time-delay mainly plays a negative role in stimulating the SR phenomenon. Conversely, it could motivate the SR effect to increase the strength of the cross-correlation noise in the SNR-β plot, while the increase of additive noise intensity will firstly excite SR, and then suppress the SR effect.

Multiple-region directed functional connectivity based on phase delays.

Science.gov (United States)

Goelman, Gadi; Dan, Rotem

2017-03-01

Network analysis is increasingly advancing the field of neuroimaging. Neural networks are generally constructed from pairwise interactions with an assumption of linear relations between them. Here, a high-order statistical framework to calculate directed functional connectivity among multiple regions, using wavelet analysis and spectral coherence has been presented. The mathematical expression for 4 regions was derived and used to characterize a quartet of regions as a linear, combined (nonlinear), or disconnected network. Phase delays between regions were used to obtain network's temporal hierarchy and directionality. The validity of the mathematical derivation along with the effects of coupling strength and noise on its outcomes were studied by computer simulations of the Kuramoto model. The simulations demonstrated correct directionality for a large range of coupling strength and low sensitivity to Gaussian noise compared with pairwise coherences. The analysis was applied to resting-state fMRI data of 40 healthy young subjects to characterize the ventral visual system, motor system and default mode network (DMN). It was shown that the ventral visual system was predominantly composed of linear networks while the motor system and the DMN were composed of combined (nonlinear) networks. The ventral visual system exhibits its known temporal hierarchy, the motor system exhibits center ↔ out hierarchy and the DMN has dorsal ↔ ventral and anterior ↔ posterior organizations. The analysis can be applied in different disciplines such as seismology, or economy and in a variety of brain data including stimulus-driven fMRI, electrophysiology, EEG, and MEG, thus open new horizons in brain research. Hum Brain Mapp 38:1374-1386, 2017. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Anxiety type modulates immediate versus delayed engagement of attention-related brain regions.

Science.gov (United States)

Spielberg, Jeffrey M; De Leon, Angeline A; Bredemeier, Keith; Heller, Wendy; Engels, Anna S; Warren, Stacie L; Crocker, Laura D; Sutton, Bradley P; Miller, Gregory A

2013-09-01

Background Habituation of the fear response, critical for the treatment of anxiety, is inconsistently observed during exposure to threatening stimuli. One potential explanation for this inconsistency is differential attentional engagement with negatively valenced stimuli as a function of anxiety type. Methods The present study tested this hypothesis by examining patterns of neural habituation associated with anxious arousal, characterized by panic symptoms and immediate engagement with negatively valenced stimuli, versus anxious apprehension, characterized by engagement in worry to distract from negatively valenced stimuli. Results As predicted, the two anxiety types evidenced distinct patterns of attentional engagement. Anxious arousal was associated with immediate activation in attention-related brain regions that habituated over time, whereas anxious apprehension was associated with delayed activation in attention-related brain regions that occurred only after habituation in a worry-related brain region. Conclusions Results further elucidate mechanisms involved in attention to negatively valenced stimuli and indicate that anxiety is a heterogeneous construct with regard to attention to such stimuli.

Wigner-Eisenbud-Smith photoionization time delay due to autoioinization resonances

Science.gov (United States)

Deshmukh, P. C.; Kumar, A.; Varma, H. R.; Banerjee, S.; Manson, Steven T.; Dolmatov, V. K.; Kheifets, A. S.

2018-03-01

An empirical ansatz for the complex photoionization amplitude and Wigner-Eisenbud-Smith time delay in the vicinity of a Fano autoionization resonance are proposed to evaluate and interpret the time delay in the resonant region. The utility of this expression is evaluated in comparison with accurate numerical calculations employing the ab initio relativistic random phase approximation and relativistic multichannel quantum defect theory. The indisputably good qualitative agreement (and semiquantitative agreement) between corresponding results of the proposed model and results produced by the ab initio theories proves the usability of the model. In addition, the phenomenology of the time delay in the vicinity of multichannel autoionizing resonances is detailed.

$\\beta$-delayed fission in proton-rich nuclei in the lead region

CERN Document Server

AUTHOR|(CDS)2085005; Huyse, Mark; Popescu, Lucia

Nuclear fission is the breakup of an atomic nucleus into two (sometimes three) fragments, thereby releasing a large amount of energy. Soon after its discovery in the late 1930’s, the gross properties of the fission phenomenon were explained by macroscopic nuclear models. Certain features however, such as asymmetric fission-fragment mass distributions in the actinide region, require the inclusion of microscopic effects. This interplay of the microscopic motion of individual nucleons on this macroscopic process is, until today, not yet fully understood. The phenomenon of fission has therefore been of recurring interest for both theoretical and experimental studies. This thesis work focuses on the $\\beta$-delayed fission ($\\beta$DF) process, an excellent tool to study low-energy fission of exotic nuclei, which was discovered in 1966 in the actinide region. In this two-step process, a precursor nucleus first undergoes $\\beta$-decay to an excited level in the daughter nucleus, which may subsequently fission. Rec...

Additional results from the β-delayed proton decays of 27P and 31Cl

International Nuclear Information System (INIS)

Ognibene, T.J.; Powell, J.; Moltz, D.M.; Rowe, M.W.; Cerny, J.

1996-01-01

β-delayed proton decays of the nuclides 27 P and 31 Cl were measured using the helium-jet recoil collection technique and low-energy particle identification detector telescopes. In 27 P, two new proton groups at 466±3 keV and 612±2 keV, with intensities of 9±2% and 97±3% relative to the main (100%) group at 731±2 keV, were discovered. Additionally, during the 27 P experiments, a new proton transition was identified following the β decay of 28 P. This group, at a proton energy of 1452±4 keV, had a 2±1% intensity relative to the 100% group at 679±1 keV. A total 27 P β-delayed proton branch of 0.07% was estimated. The experimental Gamow-Teller β-decay strengths of the observed transitions from 27 P were compared to results from shell model calculations. A search for new proton transitions in 31 Cl, the next member of this A=4n+3, T z =-3/2 series, was unsuccessful. However, several proton peaks that had been previously assigned to 31 Cl decay were shown to be from the decay of 25 Si. copyright 1996 The American Physical Society

Delayed Proton Emission in the A=70 Region, a Strobe for Level Density and Particle Width

CERN Multimedia

2002-01-01

The delayed particle emission, which is a characteristic signature of the most exotic nuclei decay, provides a wide variety of spectroscopic information among which level density, and gives in some cases access to selected microscopic structures. In regard to these two aspects the $\\beta^+$-EC delayed proton emission in the A=70 neutron deficient mass region is of special interest to be investigated. Indeed, in this area located close to the proton drip line and along the N=Z line, the delayed proton emission constitutes an access to level density in the Q$_{EC}$-S$_p$ window of the emitting nucleus. Moreover, the unbound states populated by the EC process are expected to exhibit lifetimes in the vicinity of the K electronic shell filling time ($\\tau\\!\\sim\\!2\\times10^{-16}$s) and so the particle widths can be reached via proton X-ray coincidence measurements (PXCT). From theoretical approaches strongly deformed low-spin proton unbound levels which may be populated in the T$_Z$ = 1/2 precursors decay are predi...

Increased risk of schizophrenia from additive interaction between infant motor developmental delay and obstetric complications: evidence from a population-based longitudinal study.

LENUS (Irish Health Repository)

Clarke, Mary C

2011-12-01

Obstetric complications and developmental delay are well-established risk factors for schizophrenia. The authors investigated whether these risk factors interact in an additive manner to further increase risk for schizophrenia.

Noise and time delay induce critical point in a bistable system

Science.gov (United States)

Zhang, Jianqiang; Nie, Linru; Yu, Lilong; Zhang, Xinyu

2014-07-01

We study relaxation time Tc of time-delayed bistable system driven by two cross-correlated Gaussian white noises that one is multiplicative and the other is additive. By means of numerical calculations, the results indicate that: (i) Combination of noise and time delay can induce two critical points about the relaxation time at some certain noise cross-correlation strength λ under the condition that the multiplicative intensity D equals to the additive noise intensity α. (ii) For each fixed D or α, there are two symmetrical critical points which locates in the regions of positive and negative correlations, respectively. Namely, as λ equals to the critical value λc, Tc is independent of the delay time and the result of Tc versus τ is a horizontal line, but as |λ|>|λc| (or |λ|decreases) with the delay time increasing. (iii) In the presence of D = α, the change of λc with D is two symmetrical curves about the axis of λc = 0, and the critical value λc is close to zero for a smaller D, which approaches to +1 or -1 for a greater D.

A Polynomial Estimate of Railway Line Delay

DEFF Research Database (Denmark)

Cerreto, Fabrizio; Harrod, Steven; Nielsen, Otto Anker

2017-01-01

Railway service may be measured by the aggregate delay over a time horizon or due to an event. Timetables for railway service may dampen aggregate delay by addition of additional process time, either supplement time or buffer time. The evaluation of these variables has previously been performed...... by numerical analysis with simulation. This paper proposes an analytical estimate of aggregate delay with a polynomial form. The function returns the aggregate delay of a railway line resulting from an initial, primary, delay. Analysis of the function demonstrates that there should be a balance between the two...

Delayed inflation triggerd by regional earthquakes at Campi Flegrei Caldera, Italy.

Science.gov (United States)

Lupi, M.; Frehner, M.; Weis, P.; Skelton, A.; Saenger, E.; Tisato, N.; Geiger, S.; Chiodini, G.; Driesner, T.

2017-12-01

What if earthquakes were affecting volcanoes more than we currently think because their effects are not immediately visible? Earthquake-volcano interactions promoted by dynamic and static stresses are considered seldom and difficult-to-capture geological processes. The Campi Flegrei caldera, Italy, is one of the best-monitored volcanic systems worldwide. We use a 70-years long time series to suggest a provocative and intriguing hypothesis to explain bradyseismic activity at Campi Flegrei. By comparing ground elevation time series at Campi Flegrei with seismic catalogues we show that uplift events at Campi Flegrei follow within 1.2 years large regional earthquakes. The accelerated uplifts are over-imposed on long-term inflation or deflation trends. Such association is supported by (yet-non definitive) binomial tests. Due to the non-definitive nature of the statistical tests we carried on additional numerical tests. We simulate the propagation of elastic waves showing that passing body waves impose high dynamic strains at the roof of the magmatic reservoir of the Campi Flegrei at about 7 km depth. Such elevated dynamic strains promote a brittle behaviour in an otherwise ductile material (i.e. the crystal mush) at near-lithostatic conditions. Such failure allows magma and exsolved volatiles to be released from the magmatic reservoir. The fluids would ascend through a plastic zone above the magmatic reservoir and inject into the shallow hydrothermal system where they phase-separate and expand causing a delayed effect, i.e. inflation. This mechanism and the associated inherent uncertainties require further investigations. However, the new concept already implies that geological processes triggered by passing seismic waves may become apparent several months after the triggering earthquake.

Delayed onset of tricuspid valve flow in repaired tetralogy of Fallot: an additional mechanism of diastolic dysfunction and interventricular dyssynchrony

Directory of Open Access Journals (Sweden)

Benson Lee N

2011-08-01

Full Text Available Abstract Background Diastolic dysfunction of the right ventricle (RV is common after repair of tetralogy of Fallot. While restrictive physiology in late diastole has been well known, dysfunction in early diastole has not been described. The present study sought to assess the prevalence and mechanism of early diastolic dysfunction of the RV defined as delayed onset of the tricuspid valve (TV flow after TOF repair. Methods The study population consisted of 31 children with repaired TOF (mean age ± SD, 12.3 ± 4.1 years who underwent postoperative cardiovascular magnetic resonance (CMR. The CMR protocol included simultaneous phase-contrast velocity mapping of the atrioventricular valves, which enabled direct comparison of the timing and patterns of tricuspid (TV and mitral (MV valve flow. The TV flow was defined to have delayed onset when its onset was > 20 ms later than the onset of the MV flow. The TV and MV flow from 14 normal children was used for comparison. The CMR results were correlated with the findings on echocardiography and electrocardiography. Result Delayed onset of the TV flow was observed in 16/31 patients and in none of the controls. The mean delay time was 64.81 ± 27.07 ms (8.7 ± 3.2% of R-R interval. The delay time correlated with the differences in duration of the TV and MV flow (55.94 ± 32.88 ms (r = 0.90, p Conclusions Early diastolic dysfunction with delayed onset of TV flow is common after TOF repair, and is associated with reduced RV ejection fraction. It is a further manifestation of interventricular dyssynchrony and represent an additional mechanism of ventricular diastolic dysfunction.

Delayed minocycline but not delayed mild hypothermia protects against embolic stroke

Directory of Open Access Journals (Sweden)

Noor Raza

2002-04-01

Full Text Available Abstract Background Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study, effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia on focal embolic cerebral ischemia have been examined. Methods Focal ischemic injury was induced by embolizing a preformed clot into the middle cerebral artery (MCA. Infarction volume was measured at 48 h after the injury. Mortality was also recorded. Results Delayed administration of minocycline alone or delayed minocycline plus delayed mild hypothermia reduced the infarction volume significantly. However, delayed mild hypothermia alone was not protective and delayed mild hypothermia in combination with minocycline did not show any additive effect. Conclusions These results suggest that minocycline is beneficial in focal ischemic brain injury, and the lack of the enhanced neuroprotection may be due to the brief exposure to hypothermia.

Carbonate fuel cell and components thereof for in-situ delayed addition of carbonate electrolyte

Science.gov (United States)

Johnsen, Richard [Waterbury, CT; Yuh, Chao-Yi [New Milford, CT; Farooque, Mohammad [Danbury, CT

2011-05-10

An apparatus and method in which a delayed carbonate electrolyte is stored in the storage areas of a non-electrolyte matrix fuel cell component and is of a preselected content so as to obtain a delayed time release of the electrolyte in the storage areas in the operating temperature range of the fuel cell.

Additional protocols and regional cooperation on peaceful uses of nuclear energy in northeast Asia

Energy Technology Data Exchange (ETDEWEB)

Choe, Kwan Kyoo [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

2004-07-01

The main object of this article is to clarify the relations between the implementation of the Protocols Additional to Safeguards Agreement (hereinafter referred to as the Additional Protocols) and the feasibility of the regional cooperation on peaceful uses of nuclear energy in Northeast Asia (NEA). The regionalism has a strong tendency to be based in advance on regional cooperation. The regionalism has three main structural elements in its definition: geographical proximity, cultural resemblance, and cooperative attitudes among all the countries concerned. The Additional Protocols allow the IAEA to access to more detailed information and nuclear activities of a State party. The aspect that the Additional Protocols could increase the nuclear transparency will result in ultimately promoting the confidence among the regional nations concerned.

Information transfer via implicit encoding with delay time modulation in a time-delay system

Energy Technology Data Exchange (ETDEWEB)

Kye, Won-Ho, E-mail: whkye@kipo.go.kr [Korean Intellectual Property Office, Government Complex Daejeon Building 4, 189, Cheongsa-ro, Seo-gu, Daejeon 302-701 (Korea, Republic of)

2012-08-20

A new encoding scheme for information transfer with modulated delay time in a time-delay system is proposed. In the scheme, the message is implicitly encoded into the modulated delay time. The information transfer rate as a function of encoding redundancy in various noise scales is presented and it is analyzed that the implicit encoding scheme (IES) has stronger resistance against channel noise than the explicit encoding scheme (EES). In addition, its advantages in terms of secure communication and feasible applications are discussed. -- Highlights: ► We propose new encoding scheme with delay time modulation. ► The message is implicitly encoded with modulated delay time. ► The proposed scheme shows stronger resistance against channel noise.

A Polynomial Estimate of Railway Line Delay

DEFF Research Database (Denmark)

Cerreto, Fabrizio; Harrod, Steven; Nielsen, Otto Anker

2017-01-01

Railway service may be measured by the aggregate delay over a time horizon or due to an event. Timetables for railway service may dampen aggregate delay by addition of additional process time, either supplement time or buffer time. The evaluation of these variables has previously been performed...

Leveraging delay discounting for health: Can time delays influence food choice?

Science.gov (United States)

Appelhans, Bradley M; French, Simone A; Olinger, Tamara; Bogucki, Michael; Janssen, Imke; Avery-Mamer, Elizabeth F; Powell, Lisa M

2018-03-15

Delay discounting, the tendency to choose smaller immediate rewards over larger delayed rewards, is theorized to promote consumption of immediately rewarding but unhealthy foods at the expense of long-term weight maintenance and nutritional health. An untested implication of delay discounting models of decision-making is that selectively delaying access to less healthy foods may promote selection of healthier (immediately available) alternatives, even if they may be less desirable. The current study tested this hypothesis by measuring healthy versus regular vending machine snack purchasing before and during the implementation of a 25-s time delay on the delivery of regular snacks. Purchasing was also examined under a $0.25 discount on healthy snacks, a $0.25 tax on regular snacks, and the combination of both pricing interventions with the 25-s time delay. Across 32,019 vending sales from three separate vending locations, the 25-s time delay increased healthy snack purchasing from 40.1% to 42.5%, which was comparable to the impact of a $0.25 discount (43.0%). Combining the delay and the discount had a roughly additive effect (46.0%). However, the strongest effects were seen under the $0.25 tax on regular snacks (53.7%) and the combination of the delay and the tax (50.2%). Intervention effects varied substantially between vending locations. Importantly, time delays did not harm overall vending sales or revenue, which is relevant to the real-world feasibility of this intervention. More investigation is needed to better understand how the impact of time delays on food choice varies across populations, evaluate the effects of time delays on beverage vending choices, and extend this approach to food choices in contexts other than vending machines. ClinicalTrials.gov, NCT02359916. Copyright © 2018 Elsevier Ltd. All rights reserved.

Precise delay measurement through combinatorial logic

Science.gov (United States)

Burke, Gary R. (Inventor); Chen, Yuan (Inventor); Sheldon, Douglas J. (Inventor)

2010-01-01

A high resolution circuit and method for facilitating precise measurement of on-chip delays for FPGAs for reliability studies. The circuit embeds a pulse generator on an FPGA chip having one or more groups of LUTS (the "LUT delay chain"), also on-chip. The circuit also embeds a pulse width measurement circuit on-chip, and measures the duration of the generated pulse through the delay chain. The pulse width of the output pulse represents the delay through the delay chain without any I/O delay. The pulse width measurement circuit uses an additional asynchronous clock autonomous from the main clock and the FPGA propagation delay can be displayed on a hex display continuously for testing purposes.

Synchronization in networks with heterogeneous coupling delays

Science.gov (United States)

Otto, Andreas; Radons, Günter; Bachrathy, Dániel; Orosz, Gábor

2018-01-01

Synchronization in networks of identical oscillators with heterogeneous coupling delays is studied. A decomposition of the network dynamics is obtained by block diagonalizing a newly introduced adjacency lag operator which contains the topology of the network as well as the corresponding coupling delays. This generalizes the master stability function approach, which was developed for homogenous delays. As a result the network dynamics can be analyzed by delay differential equations with distributed delay, where different delay distributions emerge for different network modes. Frequency domain methods are used for the stability analysis of synchronized equilibria and synchronized periodic orbits. As an example, the synchronization behavior in a system of delay-coupled Hodgkin-Huxley neurons is investigated. It is shown that the parameter regions where synchronized periodic spiking is unstable expand when increasing the delay heterogeneity.

A possible island of beta-delayed neutron precursors in heavy nucleus region

International Nuclear Information System (INIS)

Zhang Li

1991-01-01

The possible Beta-Delayed neutron precursors in the elements Tl, Hg, and Au were predicted following a systematic research on the known Beta-Delayed neutron precursors. The masses of the unknown nuclei and neutron emission probabilities were calculated

The WNT2 Gene Polymorphism Associated with Speech Delay Inherent to Autism

Science.gov (United States)

Lin, Ping-I; Chien, Yi-Ling; Wu, Yu-Yu; Chen, Chia-Hsiang; Gau, Susan Shur-Fen; Huang, Yu-Shu; Liu, Shih-Kai; Tsai, Wen-Che; Chiu, Yen-Nan

2012-01-01

Previous evidence suggests that language function is modulated by genetic variants on chromosome 7q31-36. However, it is unclear whether this region harbors loci that contribute to speech delay in autism. We previously reported that the WNT2 gene located on 7q31 was associated with the risk of autism. Additionally, two other genes on 7q31-36,…

Tomography with P, PP and pP delay-time data and the three-dimensional mantle structure below the Caribbean region

NARCIS (Netherlands)

van der Hilst, R.D.

1990-01-01

I address in this thesis two principal topics. Firstly, in chapters 2 and 3 I discuss improvements on the method of P delay-time tomography which were necessary to obtain reliable tomographic images of the mantle structure below the Caribbean region. These improvements include the reduction of

Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken.

Science.gov (United States)

Gao, Pengfei; Ma, Chen; Sun, Zheng; Wang, Lifeng; Huang, Shi; Su, Xiaoquan; Xu, Jian; Zhang, Heping

2017-08-03

Reducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and microbial ecology of host animals. Host phenotype and fecal microbiota of broilers with either antibiotics or probiotics as feed additive were simultaneously sampled at four time points from birth to slaughter and then compared. Probiotic feeding resulted in a lower feed conversion ratio (FCR) and induced the highest level of immunity response, suggesting greater economic benefits in broiler farming. Probiotic use but not antibiotic use recapitulated the characteristics of age-dependent development of gut microbiota in the control group. The maturation of intestinal microbiota was greatly accelerated by probiotic feeding, yet significantly retarded and eventually delayed by antibiotic feeding. LP-8 stimulated the growth of many intestinal Lactobacillus spp. and led to an altered bacterial correlation network where Lactobacillus spp. are negatively correlated with 14 genera and positively linked with none, yet from the start antibiotic feeding featured a less-organized network where such inter-genera interactions were fewer and weaker. Consistently, microbiota-encoded functions as revealed by metagenome sequencing were highly distinct between the two groups. Thus, "intestinal microbiota maturation index" was proposed to quantitatively compare impact of feed additives on animal microecology. Our results reveal a tremendous potential of probiotics as antibiotics' substitute in poultry farming.

Synchronization analysis of coloured delayed networks under ...

Indian Academy of Sciences (India)

This paper investigates synchronization of coloured delayed networks under decentralized pinning intermittent control. To begin with, the time delays are taken into account in the coloured networks. In addition, we propose a decentralized pinning intermittent control for coloured delayed networks, which is different from that ...

Stability regions for synchronized τ-periodic orbits of coupled maps with coupling delay τ

Energy Technology Data Exchange (ETDEWEB)

Karabacak, Özkan, E-mail: ozkan2917@gmail.com [Department of Electronics and Communication Engineering, Istanbul Technical University, 34469 Istanbul (Turkey); Department of Electronic Systems, Aalborg University, 9220 Aalborg East (Denmark); Alikoç, Baran, E-mail: alikoc@itu.edu.tr [Department of Control and Automation Engineering, Istanbul Technical University, 34469 Istanbul (Turkey); Atay, Fatihcan M., E-mail: atay@member.ams.org [Department of Mathematics, Bilkent University, 06800 Ankara (Turkey)

2016-09-15

Motivated by the chaos suppression methods based on stabilizing an unstable periodic orbit, we study the stability of synchronized periodic orbits of coupled map systems when the period of the orbit is the same as the delay in the information transmission between coupled units. We show that the stability region of a synchronized periodic orbit is determined by the Floquet multiplier of the periodic orbit for the uncoupled map, the coupling constant, the smallest and the largest Laplacian eigenvalue of the adjacency matrix. We prove that the stabilization of an unstable τ-periodic orbit via coupling with delay τ is possible only when the Floquet multiplier of the orbit is negative and the connection structure is not bipartite. For a given coupling structure, it is possible to find the values of the coupling strength that stabilizes unstable periodic orbits. The most suitable connection topology for stabilization is found to be the all-to-all coupling. On the other hand, a negative coupling constant may lead to destabilization of τ-periodic orbits that are stable for the uncoupled map. We provide examples of coupled logistic maps demonstrating the stabilization and destabilization of synchronized τ-periodic orbits as well as chaos suppression via stabilization of a synchronized τ-periodic orbit.

Modeling of delays in PKPD: classical approaches and a tutorial for delay differential equations.

Science.gov (United States)

Koch, Gilbert; Krzyzanski, Wojciech; Pérez-Ruixo, Juan Jose; Schropp, Johannes

2014-08-01

In pharmacokinetics/pharmacodynamics (PKPD) the measured response is often delayed relative to drug administration, individuals in a population have a certain lifespan until they maturate or the change of biomarkers does not immediately affects the primary endpoint. The classical approach in PKPD is to apply transit compartment models (TCM) based on ordinary differential equations to handle such delays. However, an alternative approach to deal with delays are delay differential equations (DDE). DDEs feature additional flexibility and properties, realize more complex dynamics and can complementary be used together with TCMs. We introduce several delay based PKPD models and investigate mathematical properties of general DDE based models, which serve as subunits in order to build larger PKPD models. Finally, we review current PKPD software with respect to the implementation of DDEs for PKPD analysis.

Systematics in delayed neutron yields

Energy Technology Data Exchange (ETDEWEB)

Ohsawa, Takaaki [Kinki Univ., Higashi-Osaka, Osaka (Japan). Atomic Energy Research Inst.

1998-03-01

An attempt was made to reproduce the systematic trend observed in the delayed neutron yields for actinides on the basis of the five-Gaussian representation of the fission yield together with available data sets for delayed neutron emission probability. It was found that systematic decrease in DNY for heavier actinides is mainly due to decrease of fission yields of precursors in the lighter side of the light fragment region. (author)

CAN LARGE TIME DELAYS OBSERVED IN LIGHT CURVES OF CORONAL LOOPS BE EXPLAINED IN IMPULSIVE HEATING?

International Nuclear Information System (INIS)

Lionello, Roberto; Linker, Jon A.; Mikić, Zoran; Alexander, Caroline E.; Winebarger, Amy R.

2016-01-01

The light curves of solar coronal loops often peak first in channels associated with higher temperatures and then in those associated with lower temperatures. The delay times between the different narrowband EUV channels have been measured for many individual loops and recently for every pixel of an active region observation. The time delays between channels for an active region exhibit a wide range of values. The maximum time delay in each channel pair can be quite large, i.e., >5000 s. These large time delays make-up 3%–26% (depending on the channel pair) of the pixels where a trustworthy, positive time delay is measured. It has been suggested that these time delays can be explained by simple impulsive heating, i.e., a short burst of energy that heats the plasma to a high temperature, after which the plasma is allowed to cool through radiation and conduction back to its original state. In this paper, we investigate whether the largest observed time delays can be explained by this hypothesis by simulating a series of coronal loops with different heating rates, loop lengths, abundances, and geometries to determine the range of expected time delays between a set of four EUV channels. We find that impulsive heating cannot address the largest time delays observed in two of the channel pairs and that the majority of the large time delays can only be explained by long, expanding loops with photospheric abundances. Additional observations may rule out these simulations as an explanation for the long time delays. We suggest that either the time delays found in this manner may not be representative of real loop evolution, or that the impulsive heating and cooling scenario may be too simple to explain the observations, and other potential heating scenarios must be explored

Bifurcation analysis of delay-induced periodic oscillations

NARCIS (Netherlands)

Green, K.

2010-01-01

In this paper we consider a generic differential equation with a cubic nonlinearity and delay. This system, in the absence of delay, is known to undergo an oscillatory instability. The addition of the delay is shown to result in the creation of a number of periodic solutions with constant amplitude

Additional beta-delayed protons from the T/sub z/ = -3/2 nuclei 21Mg, 25Si, 29S, and 41Ti

International Nuclear Information System (INIS)

Zhou, Z.Y.; Schloemer, E.C.; Cable, M.D.; Ahmed, M.; Reiff, J.E.; Cerny, J.

1985-01-01

Beta-delayed proton emission has proven to be a useful tool for understanding nuclei far from stability. Most of the beta decay strength is concentrated at and below the isobaric analog state (IAS) of the parent nucleus (precursor) ground state. Identification of beta strength to states above the IAS is important not only because it provides additional tests of nuclear models of beta decay, but also because proton emission from such beta daughter nuclei frequently constitutes an important component of the background in searches for more exotic nuclei. Therefore the authors have re-measured the beta-delayed proton spectra of four T/sub z/ = -3/2 nuclei: 21 Mg, 25 Si, 29 S, and 41 Ti. Fourteen previously unreported proton groups were observed and beta decay branching ratios were derived for each

The significance of resting thallium-201 delayed SPECT for assessing viability of infarcted regions

International Nuclear Information System (INIS)

Mori, Takao; Yamabe, Hiroshi; Yoshida, Hiroyuki; Maeda, Kazumi; Fukuzaki, Hisashi

1991-01-01

Thirty-eight patients with old myocardial infarction (OMI) and 35 patients with effort angina pectoris (EAP) underwent resting thallium-201 (Tl) SPECT one week after exercise (Ex) Tl SPECT. On the basis of both resting and Ex Tl SPECT scans, OMI patients were divided into 3 groups: those who had Tl redistribution (RD) on Ex images and the same perfusion defect (PD) on both resting and Ex delayed images (n=12, Group 1); those who had a lower PD on resting delayed images than Ex delayed images (n=15, Group 2); and those who had no Tl RD on Ex images in spite of the same PD on both resting and EX delayed images (n=11, Group 3). EAP patients were divided into Group 1 (n=18) in whom no PD was seen on Ex delayed image and Group 2 (n=17) in whom PD was not seen on Ex delayed images either, but seen on resting delayed images. EX images showed higher pulmonary artery wedge pressure in Group 2 than Group 1 of both OMI and EAP patients (27±7 mmHg vs 15±6 mmHg for OMI patients; 22±6 mmHg vs 12±7 mmHg for EAP patients). For PD, Tl uptake rate on Ex initial images was higher in Group 1 than Gorup 2 of both OMI and EAP patients (63±7% vs 55±9% for OMI patients; 72±7% vs 65±9% for EAP patients). Resting delayed images for OMI patients showed the highest Tl uptake rate in Group 1 (78±7%), followed by Group 2 (74±8%) and then Group 3 (41±10%). In the group of OMI patients, the incidence of akinetic or dyskinetic wall motion on left ventriculography was the highest in Group 3 (85.7%), followed by Group 2 (52.2%) and Group 1 (24.3%). OMI patients, as well as EAP patients, had lower PD on resting delayed images than EX delayed images. Thus, severer ischemia may be associated with stress and infarcted areas may not involve viable muscle when Tl PD is decreased on resting delayed images. (N.K.)

Controllability of nonlinear delay oscillating systems

Directory of Open Access Journals (Sweden)

Chengbin Liang

2017-05-01

Full Text Available In this paper, we study the controllability of a system governed by second order delay differential equations. We introduce a delay Gramian matrix involving the delayed matrix sine, which is used to establish sufficient and necessary conditions of controllability for the linear problem. In addition, we also construct a specific control function for controllability. For the nonlinear problem, we construct a control function and transfer the controllability problem to a fixed point problem for a suitable operator. We give a sufficient condition to guarantee the nonlinear delay system is controllable. Two examples are given to illustrate our theoretical results by calculating a specific control function and inverse of a delay Gramian matrix.

Transport of radioactive materials by air: a national approach to cope with denials and delays

International Nuclear Information System (INIS)

Perez Pijuan, Saul; Izquierdo Perez, Jorge; Rodriguez Martinez, Mercedes; Guillen Campos, Alba

2008-01-01

Full text: Around 300 nuclear medicine services in the Greater Caribbean depend, almost exclusively, on the airlines to receive radiopharmaceuticals. Less than 20 % of the regional airlines accept radioactive materials in addition to delays and denials, altogether, result in hardships to patients undergoing diagnosis and treatment, despite compliance with regulations. In the international framework leaded by the IAEA to alleviate the difficulties encountered, national approaches are needed to support this effort. The paper presents the Cuban experience regarding statistics of denials and delays by air, generic examples and classification of causes. The role of a Facilitation Working Group and actions taken in communication, awareness, harmonization of regulations, education and training are discussed. The results show a sensitive improvement in the reported instances of denials and delays at domestic level, strongly influenced by the corporative social responsibility of the main national airline and the actions underway. On the other hand, the increasing number of reported denials by international airlines in the last two years, demonstrate how much work must be done at regional and international level. (author)

Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation

NARCIS (Netherlands)

Janssen, Paddy K C; Zwinderman, Aeilko H; Olivier, Berend; Waldinger, Marcel D

PURPOSE: To investigate the association between the 5-HT-transporter-gene-linked promoter region (5-HTTLPR) polymorphism and 20-mg paroxetine-induced ejaculation delay in men with lifelong premature ejaculation (LPE). MATERIALS AND METHODS: This was a prospective study of 10 weeks of paroxetine

Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice.

Science.gov (United States)

Hara, Hideyuki; Miyata, Hironori; Das, Nandita Rani; Chida, Junji; Yoshimochi, Tatenobu; Uchiyama, Keiji; Watanabe, Hitomi; Kondoh, Gen; Yokoyama, Takashi; Sakaguchi, Suehiro

2018-01-01

Conformational conversion of the cellular isoform of prion protein, PrP C , into the abnormally folded, amyloidogenic isoform, PrP Sc , is a key pathogenic event in prion diseases, including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy (BSE) in animals. We previously reported that the octapeptide repeat (OR) region could be dispensable for converting PrP C into PrP Sc after infection with RML prions. We demonstrated that mice transgenically expressing mouse PrP with deletion of the OR region on the PrP knockout background, designated Tg(PrPΔOR)/ Prnp 0 / 0 mice, did not show reduced susceptibility to RML scrapie prions, with abundant accumulation of PrP Sc ΔOR in their brains. We show here that Tg(PrPΔOR)/ Prnp 0 / 0 mice were highly resistant to BSE prions, developing the disease with markedly elongated incubation times after infection with BSE prions. The conversion of PrPΔOR into PrP Sc ΔOR was markedly delayed in their brains. These results suggest that the OR region may have a crucial role in the conversion of PrP C into PrP Sc after infection with BSE prions. However, Tg(PrPΔOR)/ Prnp 0 / 0 mice remained susceptible to RML and 22L scrapie prions, developing the disease without elongated incubation times after infection with RML and 22L prions. PrP Sc ΔOR accumulated only slightly less in the brains of RML- or 22L-infected Tg(PrPΔOR)/ Prnp 0 / 0 mice than PrP Sc in control wild-type mice. Taken together, these results indicate that the OR region of PrP C could play a differential role in the pathogenesis of BSE prions and RML or 22L scrapie prions. IMPORTANCE Structure-function relationship studies of PrP C conformational conversion into PrP Sc are worthwhile to understand the mechanism of the conversion of PrP C into PrP Sc We show here that, by inoculating Tg(PrPΔOR)/ Prnp 0 / 0 mice with the three different strains of RML, 22L, and BSE prions, the OR region could play a differential role in the conversion of

The effective delayed neutron fraction for bare-metal criticals

International Nuclear Information System (INIS)

Pearlstein, S.

1999-01-01

Given sufficient material, a large number of actinides could be used to form bare-metal criticals. The effective delayed neutron fraction for a bare critical comprised of a fissile material is comparable with the absolute delayed neutron fraction. The effective delayed neutron fraction for a bare critical composed of a fissionable material is reduced by factors of 2 to 10 when compared with the absolute delayed neutron fraction. When the effective delayed neutron fraction is small, the difference between delayed and prompt criticality is small, and extreme caution must be used in critical assemblies of these materials. This study uses an approximate but realistic model to survey the actinide region to compare effective delayed neutron fractions with absolute delayed neutron fractions

Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty.

Directory of Open Access Journals (Sweden)

Diana L Cousminer

Full Text Available Constitutional delay of growth and puberty (CDGP is the most common cause of pubertal delay. CDGP is defined as the proportion of the normal population who experience pubertal onset at least 2 SD later than the population mean, representing 2.3% of all adolescents. While adolescents with CDGP spontaneously enter puberty, they are at risk for short stature, decreased bone mineral density, and psychosocial problems. Genetic factors contribute heavily to the timing of puberty, but the vast majority of CDGP cases remain biologically unexplained, and there is no definitive test to distinguish CDGP from pathological absence of puberty during adolescence. Recently, we published a study identifying significant linkage between a locus at the pericentromeric region of chromosome 2 (chr 2 and CDGP in Finnish families. To investigate this region for causal variation, we sequenced chr 2 between the genomic coordinates of 79-124 Mb (genome build GRCh37 in the proband and affected parent of the 13 families contributing most to this linkage signal. One gene, DNAH6, harbored 6 protein-altering low-frequency variants (< 6% in the Finnish population in 10 of the CDGP probands. We sequenced an additional 135 unrelated Finnish CDGP subjects and utilized the unique Sequencing Initiative Suomi (SISu population reference exome set to show that while 5 of these variants were present in the CDGP set, they were also present in the Finnish population at similar frequencies. Additional variants in the targeted region could not be prioritized for follow-up, possibly due to gaps in sequencing coverage or lack of functional knowledge of non-genic genomic regions. Thus, despite having a well-characterized sample collection from a genetically homogeneous population with a large population-based reference sequence dataset, we were unable to pinpoint variation in the linked region predisposing delayed puberty. This study highlights the difficulties of detecting genetic variants

Predator-prey-subsidy population dynamics on stepping-stone domains with dispersal delays.

Science.gov (United States)

Eide, Ragna M; Krause, Andrew L; Fadai, Nabil T; Van Gorder, Robert A

2018-08-14

We examine the role of the travel time of a predator along a spatial network on predator-prey population interactions, where the predator is able to partially or fully sustain itself on a resource subsidy. The impact of access to food resources on the stability and behaviour of the predator-prey-subsidy system is investigated, with a primary focus on how incorporating travel time changes the dynamics. The population interactions are modelled by a system of delay differential equations, where travel time is incorporated as discrete delay in the network diffusion term in order to model time taken to migrate between spatial regions. The model is motivated by the Arctic ecosystem, where the Arctic fox consumes both hunted lemming and scavenged seal carcass. The fox travels out on sea ice, in addition to quadrennially migrating over substantial distances. We model the spatial predator-prey-subsidy dynamics through a "stepping-stone" approach. We find that a temporal delay alone does not push species into extinction, but rather may stabilize or destabilize coexistence equilibria. We are able to show that delay can stabilize quasi-periodic or chaotic dynamics, and conclude that the incorporation of dispersal delay has a regularizing effect on dynamics, suggesting that dispersal delay can be proposed as a solution to the paradox of enrichment. Copyright © 2018 Elsevier Ltd. All rights reserved.

Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation

NARCIS (Netherlands)

Janssen, Paddy K. C.; Zwinderman, Aeilko H.; Olivier, Berend; Waldinger, Marcel D.

2014-01-01

To investigate the association between the 5-HT-transporter-gene-linked promoter region (5-HTTLPR) polymorphism and 20-mg paroxetine-induced ejaculation delay in men with lifelong premature ejaculation (LPE). This was a prospective study of 10 weeks of paroxetine treatment in 54 men with LPE.

Delay, doubt, and decision: how delaying a choice reduces the appeal of (descriptively) normative options.

Science.gov (United States)

van de Ven, Niels; Gilovich, Thomas; Zeelenberg, Marcel

2010-04-01

To help explain a regularity in democratic elections, we examined whether choosing to delay making a choice between a focal option and an alternative tends to make people subsequently less likely to choose what they would otherwise have chosen. The results of two experiments demonstrated that participants who were induced to delay making a decision were indeed less likely to choose the descriptively normative option. An additional experiment that primed a sense of doubt in participants provided support for a self-perception account of this result. Electing to delay making a choice is interpreted as an indication of doubt--doubt that tends to be attributed to the most prominent option. Delay-induced doubt about the normative option makes it less likely to be selected.

Delays in the management of retroperitoneal sarcomas

DEFF Research Database (Denmark)

Seinen, Jojanneke; Almquist, Martin; Styring, Emelie

2010-01-01

Retroperitoneal sarcomas are rare and treatment should optimally be centralized. Despite successful centralization with 90% of the patients referred prior to surgery, delays occur, which led us to assess lead times in a population-based series. Method. Patients diagnosed with retroperitoneal...... sarcoma in the southern Sweden health care region 2003-2009 were eligible for the study. Data on referrals and diagnostic investigations were collected from clinical files from primary health care, local hospitals, and from the sarcoma centre. Lead times were divided into patient delays and health care...... delays caused by primary health care, local hospitals, or procedures at the sarcoma centre. Results. Complete data were available from 33 patients and demonstrated a median patient delay of 23¿days (0-17¿months) and median health care delay of 94¿days (1-40¿months) with delays of median 15¿days...

Delayed Post Mortem Predation in Lightning Strike Carcasses ...

African Journals Online (AJOL)

Campbell Murn

An adult giraffe was struck dead by lightning on a game farm outside. Phalaborwa, South Africa in March 2014. Interestingly, delayed post-mortem predation occurred on the carcass, which according to the farm owners was an atypical phenomenon for the region. Delayed post-mortem scavenging on lightning strike ...

Delayed traumatic intracranial hematoma

International Nuclear Information System (INIS)

Tomita, Hiroki

1984-01-01

CT was performed serially within 24 hours after head injury in 64 patients having Glasgow Coma Scale of 14 or less or cranial fracture shown on roentgenogram. Delayed traumatic extradural hematoma was observed within 7-12 hours after head injury in 6 cases (9.4%). This was prominent in the frontal and occipital regions (67%). Good recovery was seen in 83.3%. Delayed traumatic intracerebral hematoma was observed within 6-24 hours after head injury in 17 cases (26.6%). This higher incidence was related to contre coup injury. Conservative treatment was possible in 14 of the 17 patients (82.4%), showing good recovery in 70%. (Namekawa, K.)

A comparison of the smeared-dislocation and super-dislocation description of a hydrided region in the context of modelling delayed hydride cracking initiation

International Nuclear Information System (INIS)

Smith, E.

1994-01-01

In quantifying the stress distribution within a hydrided region in the context of modelling delayed hydride cracking (DHC) initiation in zirconium alloys, this paper highlights the desirability of accounting for image effects, i.e. the interaction between the hydrided region and any free surface, for example a sharp crack, blunt notch or planar surface. The super-dislocation representation of a finite thickness hydrided region is ideal for accounting for image effects. It also adequately accounts for the finite thickness, t, of a hydrided region provided, as is the case in practice, we are concerned with the stress value within the hydride at distances ≥ 0.25 t from an end of the region. (Author)

Delay time in a single barrier for a movable quantum shutter

International Nuclear Information System (INIS)

Hernandez, Alberto

2010-01-01

The transient solution and delay time for a δ potential scatterer with a movable quantum shutter is calculated by solving analytically the time-dependent Schroedinger equation. The delay time is analyzed as a function of the distance between the shutter and the potential barrier and also as a function of the distance between the potential barrier and the detector. In both cases, it is found that the delay time exhibits a dynamical behavior and that it tends to a saturation value Δt sat in the limit of very short distances, which represents the maximum delay produced by the potential barrier near the interaction region. The phase time τ θ , on the other hand, is not an appropriate time scale for measuring the time delay near the interaction region, except if the shutter is moved far away from the potential. The role played by the antibound state of the system on the behavior of the delay time is also discussed.

Improved delay-dependent globally asymptotic stability of delayed uncertain recurrent neural networks with Markovian jumping parameters

International Nuclear Information System (INIS)

Yan, Ji; Bao-Tong, Cui

2010-01-01

In this paper, we have improved delay-dependent stability criteria for recurrent neural networks with a delay varying over a range and Markovian jumping parameters. The criteria improve over some previous ones in that they have fewer matrix variables yet less conservatism. In addition, a numerical example is provided to illustrate the applicability of the result using the linear matrix inequality toolbox in MATLAB. (general)

Importance of delayed neutron data in transmutation system

International Nuclear Information System (INIS)

Tsujimoto, Kazufumi

1999-01-01

The accelerator-driven transmutation system has been studied at the Japan Atomic Energy Research Institute. This system is a hybrid system which consists of a high intensity accelerator, a spallation target and a subcritical core region. The subcritical core is driven by neutrons generated by spallation reaction in the target region. There is no control rod in this system, so the power is controlled only by proton beam current. The beam current to keep constant power change with effective multiplication factor of subcritical core. So, the evaluation of delayed neutron fraction which is strongly connected to the measurement of subcritical level is important factor in operation of accelerator-driven system. In this paper, important nuclides for the delayed neutron fraction of ADS will be discussed, moreover, present state of delayed neutron data in evaluated nuclear data library is presented. (author)

Constructing Hopf bifurcation lines for the stability of nonlinear systems with two time delays

Science.gov (United States)

Nguimdo, Romain Modeste

2018-03-01

Although the plethora real-life systems modeled by nonlinear systems with two independent time delays, the algebraic expressions for determining the stability of their fixed points remain the Achilles' heel. Typically, the approach for studying the stability of delay systems consists in finding the bifurcation lines separating the stable and unstable parameter regions. This work deals with the parametric construction of algebraic expressions and their use for the determination of the stability boundaries of fixed points in nonlinear systems with two independent time delays. In particular, we concentrate on the cases for which the stability of the fixed points can be ascertained from a characteristic equation corresponding to that of scalar two-delay differential equations, one-component dual-delay feedback, or nonscalar differential equations with two delays for which the characteristic equation for the stability analysis can be reduced to that of a scalar case. Then, we apply our obtained algebraic expressions to identify either the parameter regions of stable microwaves generated by dual-delay optoelectronic oscillators or the regions of amplitude death in identical coupled oscillators.

Time delays, population, and economic development

Science.gov (United States)

Gori, Luca; Guerrini, Luca; Sodini, Mauro

2018-05-01

This research develops an augmented Solow model with population dynamics and time delays. The model produces either a single stationary state or multiple stationary states (able to characterise different development regimes). The existence of time delays may cause persistent fluctuations in both economic and demographic variables. In addition, the work identifies in a simple way the reasons why economics affects demographics and vice versa.

Chimera states in complex networks: interplay of fractal topology and delay

Science.gov (United States)

Sawicki, Jakub; Omelchenko, Iryna; Zakharova, Anna; Schöll, Eckehard

2017-06-01

Chimera states are an example of intriguing partial synchronization patterns emerging in networks of identical oscillators. They consist of spatially coexisting domains of coherent (synchronized) and incoherent (desynchronized) dynamics. We analyze chimera states in networks of Van der Pol oscillators with hierarchical connectivities, and elaborate the role of time delay introduced in the coupling term. In the parameter plane of coupling strength and delay time we find tongue-like regions of existence of chimera states alternating with regions of existence of coherent travelling waves. We demonstrate that by varying the time delay one can deliberately stabilize desired spatio-temporal patterns in the system.

Break-even price for upstream activities in Brazil: Evaluation of the opportunity cost of oil production delay in a non-mature sedimentary production region

International Nuclear Information System (INIS)

Szklo, Alexandre Salem; Machado, Giovani; Carneiro, Jason Thomas Guerreiro

2008-01-01

Some Latin American policy-makers and analysts state that it would be better to hold oil reserves in place than to produce and cash it now, given the recent oil prices spikes and the fear related to future oil supply disruptions. This article evaluates the strategy of delaying the start-up of oil production in a discovered field with proved reserves. A Reference Discounted Cash Flow (FCD-R) for a typical 350 million barrel Brazilian oil field was simulated. The study estimated which future oil price may render the project insensitive to a delay of 5, 10, 15 or 20 years in its production beginning. Additionally, the value of the in situ oil stock was calculated, providing the opportunity cost for delaying oil production in a frontier area, such as Brazil. It is an application of the Hotelling Principle. Findings indicate that progressive delays of 5 years in the start-up of operation of a typical oil field reduce its revenues by a factor of 2. A delay of 10 years would be justifiable at international oil prices higher than US $15/bbl. Delays higher than 10 years lead this break-even price to values between US $200 and 350/bbl. (author)

Facilitating tolerance of delayed reinforcement during functional communication training.

Science.gov (United States)

Fisher, W W; Thompson, R H; Hagopian, L P; Bowman, L G; Krug, A

2000-01-01

Few clinical investigations have addressed the problem of delayed reinforcement. In this investigation, three individuals whose destructive behavior was maintained by positive reinforcement were treated using functional communication training (FCT) with extinction (EXT). Next, procedures used in the basic literature on delayed reinforcement and self-control (reinforcer delay fading, punishment of impulsive responding, and provision of an alternative activity during reinforcer delay) were used to teach participants to tolerate delayed reinforcement. With the first case, reinforcer delay fading alone was effective at maintaining low rates of destructive behavior while introducing delayed reinforcement. In the second case, the addition of a punishment component reduced destructive behavior to near-zero levels and facilitated reinforcer delay fading. With the third case, reinforcer delay fading was associated with increases in masturbation and head rolling, but prompting and praising the individual for completing work during the delay interval reduced all problem behaviors and facilitated reinforcer delay fading.

Stability of Nonlinear Systems with Unknown Time-varying Feedback Delay

Science.gov (United States)

Chunodkar, Apurva A.; Akella, Maruthi R.

2013-12-01

This paper considers the problem of stabilizing a class of nonlinear systems with unknown bounded delayed feedback wherein the time-varying delay is 1) piecewise constant 2) continuous with a bounded rate. We also consider application of these results to the stabilization of rigid-body attitude dynamics. In the first case, the time-delay in feedback is modeled specifically as a switch among an arbitrarily large set of unknown constant values with a known strict upper bound. The feedback is a linear function of the delayed states. In the case of linear systems with switched delay feedback, a new sufficiency condition for average dwell time result is presented using a complete type Lyapunov-Krasovskii (L-K) functional approach. Further, the corresponding switched system with nonlinear perturbations is proven to be exponentially stable inside a well characterized region of attraction for an appropriately chosen average dwell time. In the second case, the concept of the complete type L-K functional is extended to a class of nonlinear time-delay systems with unknown time-varying time-delay. This extension ensures stability robustness to time-delay in the control design for all values of time-delay less than the known upper bound. Model-transformation is used in order to partition the nonlinear system into a nominal linear part that is exponentially stable with a bounded perturbation. We obtain sufficient conditions which ensure exponential stability inside a region of attraction estimate. A constructive method to evaluate the sufficient conditions is presented together with comparison with the corresponding constant and piecewise constant delay. Numerical simulations are performed to illustrate the theoretical results of this paper.

A Delay Line for Compression of Electromagnetic Pulses

International Nuclear Information System (INIS)

Pchelnikov, Yuriy N.; Nyce, David S.

2003-01-01

A novel method to obtain an electromagnetic signal delay is described. It is shown that the positive magnetic and electric coupling between impedance conductors produces an increase in the time delay. It is also shown that the increase in delay time is obtained without additional attenuation. This allows a reduction in electromagnetic losses, by a factor of several times, for a delay time. An approximate analysis of electromagnetic delay lines based on coupled impedance conductors with 'spiral' and 'meander' patterns allowed obtaining very simple expressions for the wave deceleration factor, wave impedance, and attenuation factor. The results of the analysis are confirmed by the results of measurements. It is shown that a delay line based on counter-wound radial spirals can be successfully used for compression of electromagnetic pulses. Although the offered delay line was designed to operate with a relatively small signal, the analysis of the 'coupling effect', taking place in this delay line, might be useful in devices for compression of high-power microwave pulses

Vascular Steal Explains Early Paradoxical Blood Oxygen Level-Dependent Cerebrovascular Response in Brain Regions with Delayed Arterial Transit Times

Directory of Open Access Journals (Sweden)

Julien Poublanc

2013-04-01

Full Text Available Introduction: Blood oxygen level-dependent (BOLD magnetic resonance imaging (MRI during manipulation of inhaled carbon dioxide (CO2 can be used to measure cerebrovascular reactivity (CVR and map regions of exhausted cerebrovascular reserve. These regions exhibit a reduced or negative BOLD response to inhaled CO2. In this study, we sought to clarify the mechanism behind the negative BOLD response by investigating its time delay (TD. Dynamic susceptibility contrast (DSC MRI with the injection of a contrast agent was used as the gold standard in order to provide measurement of the blood arrival time to which CVR TD could be compared. We hypothesize that if negative BOLD responses are the result of a steal phenomenon, they should be synchronized with positive BOLD responses from healthy brain tissue, even though the blood arrival time would be delayed. Methods: On a 3-tesla MRI system, BOLD CVR and DSC images were collected in a group of 19 patients with steno-occlusive cerebrovascular disease. For each patient, we generated a CVR magnitude map by regressing the BOLD signal with the end-tidal partial pressure of CO2 (PETCO2, and a CVR TD map by extracting the time of maximum cross-correlation between the BOLD signal and PETCO2. In addition, a blood arrival time map was generated by fitting the DSC signal with a gamma variate function. ROI masks corresponding to varying degrees of reactivity were constructed. Within these masks, the mean CVR magnitude, CVR TD and DSC blood arrival time were extracted and averaged over the 19 patients. CVR magnitude and CVR TD were then plotted against DSC blood arrival time. Results: The results show that CVR magnitude is highly correlated to DSC blood arrival time. As expected, the most compromised tissues with the longest blood arrival time have the lowest (most negative CVR magnitude. However, CVR TD shows a noncontinuous relationship with DSC blood arrival time. CVR TD is well correlated to DSC blood arrival time

Brain Structure Linking Delay Discounting and Academic Performance.

Science.gov (United States)

Wang, Song; Kong, Feng; Zhou, Ming; Chen, Taolin; Yang, Xun; Chen, Guangxiang; Gong, Qiyong

2017-08-01

As a component of self-discipline, delay discounting refers to the ability to wait longer for preferred rewards and plays a pivotal role in shaping students' academic performance. However, the neural basis of the association between delay discounting and academic performance remains largely unknown. Here, we examined the neuroanatomical substrates underlying delay discounting and academic performance in 214 adolescents via voxel-based morphometry (VBM) by performing structural magnetic resonance imaging (S-MRI). Behaviorally, we confirmed the significant correlation between delay discounting and academic performance. Neurally, whole-brain regression analyses indicated that regional gray matter volume (rGMV) of the left dorsolateral prefrontal cortex (DLPFC) was associated with both delay discounting and academic performance. Furthermore, delay discounting partly accounted for the association between academic performance and brain structure. Differences in the rGMV of the left DLPFC related to academic performance explained over one-third of the impact of delay discounting on academic performance. Overall, these results provide the first evidence for the common neural basis linking delay discounting and academic performance. Hum Brain Mapp 38:3917-3926, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

A continuous time Cournot duopoly with delays

International Nuclear Information System (INIS)

Gori, Luca; Guerrini, Luca; Sodini, Mauro

2015-01-01

This paper extends the classical repeated duopoly model with quantity-setting firms of Bischi et al. (1998) by assuming that production of goods is subject to some gestation lags but exchanges take place continuously in the market. The model is expressed in the form of differential equations with discrete delays. By using some recent mathematical techniques and numerical experiments, results show some dynamic phenomena that cannot be observed when delays are absent. In addition, depending on the extent of time delays and inertia, synchronisation failure can arise even in the event of homogeneous firms.

Permissible Delay in Payments

Directory of Open Access Journals (Sweden)

Yung-Fu Huang

2007-01-01

Full Text Available The main purpose of this paper wants to investigate the optimal retailer's lot-sizing policy with two warehouses under partially permissible delay in payments within the economic order quantity (EOQ framework. In this paper, we want to extend that fully permissible delay in payments to the supplier would offer the retailer partially permissible delay in payments. That is, the retailer must make a partial payment to the supplier when the order is received. Then the retailer must pay off the remaining balance at the end of the permissible delay period. In addition, we want to add the assumption that the retailer's storage space is limited. That is, the retailer will rent the warehouse to store these exceeding items when the order quantity is larger than retailer's storage space. Under these conditions, we model the retailer's inventory system as a cost minimization problem to determine the retailer's optimal cycle time and optimal order quantity. Three theorems are developed to efficiently determine the optimal replenishment policy for the retailer. Finally, numerical examples are given to illustrate these theorems and obtained a lot of managerial insights.

Measurements of additional X-ray flux in South Atlantic magnetic anomaly region

International Nuclear Information System (INIS)

Martin, I.M.

1968-01-01

The purpose of this study is the calculation of the additional X-ray flux (20 - 150 KeV), produced by electron precipitation in the South Atlantic anomaly region. The kind of detector and the technique employed in the observations of this flux, utilizing stratospheric balloons as a means of transport of the payload across the anomaly region, are described. The results of two balloon launchins in Sao Jose dos Campos in July 1968, with the expected flux, are compared. (author) [pt

Beta-delayed proton activities: 147Dy and 149Er

International Nuclear Information System (INIS)

Toth, K.S.; Moltz, D.M.; Schloemer, E.C.; Cable, M.D.; Avignone, F.T. III; Ellis-Akovali, Y.A.

1984-01-01

The present paper discusses mainly the β-delayed proton spectra of 147 Dy and of the hitherto unknown isotope, 149 Er. However, following the submittal of the abstract for this conference we have now observed delayed protons following the decay of 145 Dy. Additionally, we have identified a 0.5-s delayed-proton emitter and tentatively assign it to the new isotope, 151 Yb

Methods to estimate railway capacity and passenger delays

DEFF Research Database (Denmark)

Landex, Alex

that an evaluation of passenger delays obtained with simulation software (in this case RailSys) and the passenger delay model is comparable with the daily operation of the Copenhagen suburban railway network. Using a microscopic simulation model, the thesis demonstrates that it is possible to compare travel times...... of additional travel time. The differences between the different kinds of delay (train delays, passenger delays and scheduled waiting time) are illustrated through simple, but representative, case examples in CHAPTER 10. The examples demonstrate that 3rd generation passenger delay models are more realistic than...... depend on the given infrastructure and timetable and can result in longer travel times for trains and passengers. Furthermore, the thesis shows that the network effects can result in reduced capacity as some trains or train services can make it impossible to operate other planned/desired trains or train...

Expanding Regional Airport Usage to Accommodate Increased Air Traffic Demand

Science.gov (United States)

Russell, Carl R.

2009-01-01

Small regional airports present an underutilized source of capacity in the national air transportation system. This study sought to determine whether a 50 percent increase in national operations could be achieved by limiting demand growth at large hub airports and instead growing traffic levels at the surrounding regional airports. This demand scenario for future air traffic in the United States was generated and used as input to a 24-hour simulation of the national airspace system. Results of the demand generation process and metrics predicting the simulation results are presented, in addition to the actual simulation results. The demand generation process showed that sufficient runway capacity exists at regional airports to offload a significant portion of traffic from hub airports. Predictive metrics forecast a large reduction of delays at most major airports when demand is shifted. The simulation results then show that offloading hub traffic can significantly reduce nationwide delays.

IAEA safeguards and the additional protocol in the Eurasia Region

International Nuclear Information System (INIS)

Murakami, K.

2001-01-01

Developing and implementing safeguards against misuse of nuclear material and facilities has always been the Agency's main activities. Like the nuclear non-proliferation regime itself, the development of the safeguards system has been an evolutionary process. The first safeguards inspection was carried out in 1962 (in Norway). In the sixties, the basic concepts behind safeguards were developed (INFCIRC/26, adopted in 1961, for some of you it might still have a familiar ring) and the number of inspections and types of facilities inspected grew slowly. With the advent of INFCIRC/66/Rev. 2, a more complete, albeit limited, system of safeguards covering nuclear material, equipment and facilities emerged. But the quantum leap came, of course, wit the entry into force of the NPT. Today, the IAEA has 224 safeguards agreements in force with 140 States. Nearly all of these States are NPT States. In the Eurasia Region, particularly the Newly Independent States (NIS) significant achievements have been made in the Safeguards Implementation. States with nuclear activities have the SG Agreement in force. Some states are already signing the Additional Protocol and it is in force in two of these States in the NIS region. Much progress has been made in the area of nuclear material and accountancy through the IAEA Coordinated Technical Support Programme (CTSP). The programme was organized to co-ordinate the donor states activities and has been successful for the last seven years in providing assistance in the area of nuclear legislation establishment of the State System of Accountancy of nuclear material (SSAC) and other related areas. Improvement is still foreseen in these areas, particularly as more states in the region will be signing and implementing the Additional Protocols

Goodwin accelerator model revisited with fixed time delays

Science.gov (United States)

Matsumoto, Akio; Merlone, Ugo; Szidarovszky, Ferenc

2018-05-01

Dynamics of Goodwin's accelerator business cycle model is reconsidered. The model is characterized by a nonlinear accelerator and an investment time delay. The role of the nonlinearity for the birth of persistent oscillations is fully discussed in the existing literature. On the other hand, not much of the role of the delay has yet been revealed. The purpose of this paper is to show that the delay really matters. In the original framework of Goodwin [6], it is first demonstrated that there is a threshold value of the delay: limit cycles arise for smaller values than the threshold and so do sawtooth oscillations for larger values. In the extended framework in which a consumption or saving delay, in addition to the investment delay, is introduced, three main results are demonstrated under assumption of the identical length of investment and consumption delays. The dynamics with consumption delay is basically the same as that of the single delay model. Second, in the case of saving delay, the steady state can coexist with the stable and unstable limit cycles in the stable case. Third, in the unstable case, there is an interval of delay in which the limit cycle or the sawtooth oscillation emerges depending on the choice of the constant initial function.

Noise-sustained fluctuations in stochastic dynamics with a delay.

Science.gov (United States)

D'Odorico, Paolo; Laio, Francesco; Ridolfi, Luca

2012-04-01

Delayed responses to external drivers are ubiquitous in environmental, social, and biological processes. Delays may induce oscillations, Hopf bifurcations, and instabilities in deterministic systems even in the absence of nonlinearities. Despite recent advances in the study of delayed stochastic differential equations, the interaction of random drivers with delays remains poorly understood. In particular, it is unclear whether noise-induced behaviors may emerge from these interactions. Here we show that noise may enhance and sustain transient periodic oscillations inherent to deterministic delayed systems. We investigate the conditions conducive to the emergence and disappearance of these dynamics in a linear system in the presence of both additive and multiplicative noise.

Tunable delay time and Hartman effect in graphene magnetic barriers

International Nuclear Information System (INIS)

Ban, Yue; Wang, Lin-Jun; Chen, Xi

2015-01-01

Tunable group delay and Hartman effect have been investigated for massless Dirac electrons in graphene magnetic barriers. In the presence of magnetic field, dwell time is found to be equal to net group delay plus the group delay contributing from the lateral shifts. The group delay times are discussed in both cases of normal and oblique incidence, to clarify the nature of Hartman effect. In addition, the group delay in transmission can be modulated from subluminality to superluminality by adjusting the magnetic field, which may also lead to potential applications in graphene-based microelectronics

Modeling delay in genetic networks: from delay birth-death processes to delay stochastic differential equations.

Science.gov (United States)

Gupta, Chinmaya; López, José Manuel; Azencott, Robert; Bennett, Matthew R; Josić, Krešimir; Ott, William

2014-05-28

Delay is an important and ubiquitous aspect of many biochemical processes. For example, delay plays a central role in the dynamics of genetic regulatory networks as it stems from the sequential assembly of first mRNA and then protein. Genetic regulatory networks are therefore frequently modeled as stochastic birth-death processes with delay. Here, we examine the relationship between delay birth-death processes and their appropriate approximating delay chemical Langevin equations. We prove a quantitative bound on the error between the pathwise realizations of these two processes. Our results hold for both fixed delay and distributed delay. Simulations demonstrate that the delay chemical Langevin approximation is accurate even at moderate system sizes. It captures dynamical features such as the oscillatory behavior in negative feedback circuits, cross-correlations between nodes in a network, and spatial and temporal information in two commonly studied motifs of metastability in biochemical systems. Overall, these results provide a foundation for using delay stochastic differential equations to approximate the dynamics of birth-death processes with delay.

Modeling delay in genetic networks: From delay birth-death processes to delay stochastic differential equations

Energy Technology Data Exchange (ETDEWEB)

Gupta, Chinmaya; López, José Manuel; Azencott, Robert; Ott, William [Department of Mathematics, University of Houston, Houston, Texas 77004 (United States); Bennett, Matthew R. [Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77204, USA and Institute of Biosciences and Bioengineering, Rice University, Houston, Texas 77005 (United States); Josić, Krešimir [Department of Mathematics, University of Houston, Houston, Texas 77004 (United States); Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 (United States)

2014-05-28

Delay is an important and ubiquitous aspect of many biochemical processes. For example, delay plays a central role in the dynamics of genetic regulatory networks as it stems from the sequential assembly of first mRNA and then protein. Genetic regulatory networks are therefore frequently modeled as stochastic birth-death processes with delay. Here, we examine the relationship between delay birth-death processes and their appropriate approximating delay chemical Langevin equations. We prove a quantitative bound on the error between the pathwise realizations of these two processes. Our results hold for both fixed delay and distributed delay. Simulations demonstrate that the delay chemical Langevin approximation is accurate even at moderate system sizes. It captures dynamical features such as the oscillatory behavior in negative feedback circuits, cross-correlations between nodes in a network, and spatial and temporal information in two commonly studied motifs of metastability in biochemical systems. Overall, these results provide a foundation for using delay stochastic differential equations to approximate the dynamics of birth-death processes with delay.

Modeling delay in genetic networks: From delay birth-death processes to delay stochastic differential equations

International Nuclear Information System (INIS)

Gupta, Chinmaya; López, José Manuel; Azencott, Robert; Ott, William; Bennett, Matthew R.; Josić, Krešimir

2014-01-01

Delay is an important and ubiquitous aspect of many biochemical processes. For example, delay plays a central role in the dynamics of genetic regulatory networks as it stems from the sequential assembly of first mRNA and then protein. Genetic regulatory networks are therefore frequently modeled as stochastic birth-death processes with delay. Here, we examine the relationship between delay birth-death processes and their appropriate approximating delay chemical Langevin equations. We prove a quantitative bound on the error between the pathwise realizations of these two processes. Our results hold for both fixed delay and distributed delay. Simulations demonstrate that the delay chemical Langevin approximation is accurate even at moderate system sizes. It captures dynamical features such as the oscillatory behavior in negative feedback circuits, cross-correlations between nodes in a network, and spatial and temporal information in two commonly studied motifs of metastability in biochemical systems. Overall, these results provide a foundation for using delay stochastic differential equations to approximate the dynamics of birth-death processes with delay

Epidemiology, diagnostic delay and outcome of tuberculosis in North Jutland, Denmark

DEFF Research Database (Denmark)

Andersen, Rosa M Ø; Bjørn-Præst, Simon O; Oren Gradel, Kim

2011-01-01

The objective of this study was to evaluate the clinical outcome of tuberculosis (TB) with regards to epidemiology, symptoms, delay, diagnostics, use of HIV-test, treatment, treatment outcome and mortality in the North Jutland Region from 2000 through 2008.......The objective of this study was to evaluate the clinical outcome of tuberculosis (TB) with regards to epidemiology, symptoms, delay, diagnostics, use of HIV-test, treatment, treatment outcome and mortality in the North Jutland Region from 2000 through 2008....

Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice

International Nuclear Information System (INIS)

Nabeshima, T.; Katoh, A.; Ishimaru, H.; Yoneda, Y.; Ogita, K.; Murase, K.; Ohtsuka, H.; Inari, K.; Fukuta, T.; Kameyama, T.

1991-01-01

We investigated the interrelationship of delayed amnesia, delayed neuronal death and changes in acetylcholine concentration induced by carbon monoxide (CO)-exposure in mice. In the test for retention of the passive avoidance task, amnesia was observed 5 and 7 days after CO-exposure when the mice were exposed to CO 1 day after training; in the case when the mice were exposed to CO 5 and 7 days before training, amnesia was also observed in a retention test given 1 day after training. The number of pyramidal cells in the hippocampal CA1 subfield was lower than that of the control 3, 5 and 7 days after CO-exposure. But the neurodegeneration in the parietal cortex, area 1, was not observed until 7 days after CO-exposure. The findings indicated that the amnesia and the neuronal death were produced after a delay when the mice were exposed to CO. In addition, the delayed amnesia was closely related to the delayed neuronal death in the hippocampal CA1 subfield. Moreover, [3H]glutamate and [3H]glycine binding sites did not change after CO-exposure but, 7 days after CO-exposure, the concentration of acetylcholine and the binding of [3H]quinuclidinyl benzilate in the frontal cortex and the striatum were found to have significantly changed, but those in the hippocampus did not show significant change. Therefore, we suggest that delayed amnesia induced by CO-exposure may result from delayed neuronal death in the hippocampal CA1 subfield and dysfunction in the acetylcholinergic neurons, in the frontal cortex, the striatum and/or the hippocampus

Carbon monoxide-induced delayed amnesia, delayed neuronal death and change in acetylcholine concentration in mice

Energy Technology Data Exchange (ETDEWEB)

Nabeshima, T.; Katoh, A.; Ishimaru, H.; Yoneda, Y.; Ogita, K.; Murase, K.; Ohtsuka, H.; Inari, K.; Fukuta, T.; Kameyama, T. (Meijo Univ., Nagoya (Japan))

1991-01-01

We investigated the interrelationship of delayed amnesia, delayed neuronal death and changes in acetylcholine concentration induced by carbon monoxide (CO)-exposure in mice. In the test for retention of the passive avoidance task, amnesia was observed 5 and 7 days after CO-exposure when the mice were exposed to CO 1 day after training; in the case when the mice were exposed to CO 5 and 7 days before training, amnesia was also observed in a retention test given 1 day after training. The number of pyramidal cells in the hippocampal CA1 subfield was lower than that of the control 3, 5 and 7 days after CO-exposure. But the neurodegeneration in the parietal cortex, area 1, was not observed until 7 days after CO-exposure. The findings indicated that the amnesia and the neuronal death were produced after a delay when the mice were exposed to CO. In addition, the delayed amnesia was closely related to the delayed neuronal death in the hippocampal CA1 subfield. Moreover, (3H)glutamate and (3H)glycine binding sites did not change after CO-exposure but, 7 days after CO-exposure, the concentration of acetylcholine and the binding of (3H)quinuclidinyl benzilate in the frontal cortex and the striatum were found to have significantly changed, but those in the hippocampus did not show significant change. Therefore, we suggest that delayed amnesia induced by CO-exposure may result from delayed neuronal death in the hippocampal CA1 subfield and dysfunction in the acetylcholinergic neurons, in the frontal cortex, the striatum and/or the hippocampus.

The diffusive Lotka-Volterra predator-prey system with delay.

Science.gov (United States)

Al Noufaey, K S; Marchant, T R; Edwards, M P

2015-12-01

Semi-analytical solutions for the diffusive Lotka-Volterra predator-prey system with delay are considered in one and two-dimensional domains. The Galerkin method is applied, which approximates the spatial structure of both the predator and prey populations. This approach is used to obtain a lower-order, ordinary differential delay equation model for the system of governing delay partial differential equations. Steady-state and transient solutions and the region of parameter space, in which Hopf bifurcations occur, are all found. In some cases simple linear expressions are found as approximations, to describe steady-state solutions and the Hopf parameter regions. An asymptotic analysis for the periodic solution near the Hopf bifurcation point is performed for the one-dimensional domain. An excellent agreement is shown in comparisons between semi-analytical and numerical solutions of the governing equations. Copyright © 2015 Elsevier Inc. All rights reserved.

Relativistic time delays in the Dirac approach to nucleon-nucleus scattering

International Nuclear Information System (INIS)

Suzuki, T.

1993-01-01

In connection with a characteristic feature of the effective optical potential in the Dirac approach two types of time delays are considered in the relativistic eikonal approximation. One is obtained from the scattering amplitude and the other given by the wave packet motion in the interaction region. These time delays turn out to differ in sign at intermediate energies, in contrast to the agreement between corresponding nonrelativistic time delays. (orig.)

Developmental delay in the Amazon: The social determinants and prevalence among rural communities in Peru.

Science.gov (United States)

Westgard, Christopher; Alnasser, Yossef

2017-01-01

The consequences of poor child development are becoming increasingly recognized. Programs are being put in place around the world to improve child development by providing healthy and stimulating environments for children. However, these programs often have limited reach and little is known about the prevalence of developmental delay in under-developed communities. The current study set-out to better understand the prevalence of developmental delay in rural communities in the Amazon region of Peru. Also, it explores social determinants that are associated with any delay. Cross-sectional study by evaluating developmental delay in children under 4 years utilizing Ages and Stages Questionnaire (ASQ-3). Additionally, conducting a social determinants questionnaire answered by caretakers to identify social drivers for developmental delay. The data was analyzed with multi-variant analysis to measure association. The prevalence of developmental delay in the Amazonian communities was 26.7% (19.3% in communication, 11.4% in gross motor skills, 8% in both) (N = 596). The multivariate logistic regression analysis revealed significant associations between developmental delay and; level of education (OR 0.64, p = 0.009), age of mother during child's birth (OR 0.96, p = 0.002), visits by community health agents (OR 0.73, p = 0.013), and river as primary water source (OR 2.39, p = 0.001). The social determinants questionnaire revealed that 39% of the mothers had their first child before the age of 17, nearly half stopped going to school before the age of 12 (52%), 29% gave birth at home, 13% breast fed for less than 7 months, and 50% of the children had diarrhea in the last month. There is still a great need to improve the conditions for child development in the Amazon region of Peru. One-fourth of the children suffer from developmental delay, which will likely impede their potentials for life unless something is done. The impact of education, age of mother at birth of the child

Developmental delay in the Amazon: The social determinants and prevalence among rural communities in Peru.

Directory of Open Access Journals (Sweden)

Christopher Westgard

Full Text Available The consequences of poor child development are becoming increasingly recognized. Programs are being put in place around the world to improve child development by providing healthy and stimulating environments for children. However, these programs often have limited reach and little is known about the prevalence of developmental delay in under-developed communities. The current study set-out to better understand the prevalence of developmental delay in rural communities in the Amazon region of Peru. Also, it explores social determinants that are associated with any delay. Cross-sectional study by evaluating developmental delay in children under 4 years utilizing Ages and Stages Questionnaire (ASQ-3. Additionally, conducting a social determinants questionnaire answered by caretakers to identify social drivers for developmental delay. The data was analyzed with multi-variant analysis to measure association. The prevalence of developmental delay in the Amazonian communities was 26.7% (19.3% in communication, 11.4% in gross motor skills, 8% in both (N = 596. The multivariate logistic regression analysis revealed significant associations between developmental delay and; level of education (OR 0.64, p = 0.009, age of mother during child's birth (OR 0.96, p = 0.002, visits by community health agents (OR 0.73, p = 0.013, and river as primary water source (OR 2.39, p = 0.001. The social determinants questionnaire revealed that 39% of the mothers had their first child before the age of 17, nearly half stopped going to school before the age of 12 (52%, 29% gave birth at home, 13% breast fed for less than 7 months, and 50% of the children had diarrhea in the last month. There is still a great need to improve the conditions for child development in the Amazon region of Peru. One-fourth of the children suffer from developmental delay, which will likely impede their potentials for life unless something is done. The impact of education, age of mother at birth of

Data Mining for Understanding and Impriving Decision-Making Affecting Ground Delay Programs

Science.gov (United States)

Kulkarni, Deepak; Wang, Yao Xun; Sridhar, Banavar

2013-01-01

The continuous growth in the demand for air transportation results in an imbalance between airspace capacity and traffic demand. The airspace capacity of a region depends on the ability of the system to maintain safe separation between aircraft in the region. In addition to growing demand, the airspace capacity is severely limited by convective weather. During such conditions, traffic managers at the FAA's Air Traffic Control System Command Center (ATCSCC) and dispatchers at various Airlines' Operations Center (AOC) collaborate to mitigate the demand-capacity imbalance caused by weather. The end result is the implementation of a set of Traffic Flow Management (TFM) initiatives such as ground delay programs, reroute advisories, flow metering, and ground stops. Data Mining is the automated process of analyzing large sets of data and then extracting patterns in the data. Data mining tools are capable of predicting behaviors and future trends, allowing an organization to benefit from past experience in making knowledge-driven decisions. The work reported in this paper is focused on ground delay programs. Data mining algorithms have the potential to develop associations between weather patterns and the corresponding ground delay program responses. If successful, they can be used to improve and standardize TFM decision resulting in better predictability of traffic flows on days with reliable weather forecasts. The approach here seeks to develop a set of data mining and machine learning models and apply them to historical archives of weather observations and forecasts and TFM initiatives to determine the extent to which the theory can predict and explain the observed traffic flow behaviors.

A unified approach for impulsive lag synchronization of chaotic systems with time delay

International Nuclear Information System (INIS)

Li Chuandong; Liao Xiaofeng; Zhang Rong

2005-01-01

In this paper, we propose a unified approach for impulsive lag-synchronization of a class of chaotic systems with time delay by employing the stability theory of impulsive delayed differential equations. Three well-known delayed chaotic systems are presented to illustrate our results. Also, the estimates of the stable regions for these systems are given, respectively

Moments of the Wigner delay times

International Nuclear Information System (INIS)

Berkolaiko, Gregory; Kuipers, Jack

2010-01-01

The Wigner time delay is a measure of the time spent by a particle inside the scattering region of an open system. For chaotic systems, the statistics of the individual delay times (whose average is the Wigner time delay) are thought to be well described by random matrix theory. Here we present a semiclassical derivation showing the validity of random matrix results. In order to simplify the semiclassical treatment, we express the moments of the delay times in terms of correlation functions of scattering matrices at different energies. In the semiclassical approximation, the elements of the scattering matrix are given in terms of the classical scattering trajectories, requiring one to study correlations between sets of such trajectories. We describe the structure of correlated sets of trajectories and formulate the rules for their evaluation to the leading order in inverse channel number. This allows us to derive a polynomial equation satisfied by the generating function of the moments. Along with showing the agreement of our semiclassical results with the moments predicted by random matrix theory, we infer that the scattering matrix is unitary to all orders in the semiclassical approximation.

Optimal Joint Expected Delay Forwarding in Delay Tolerant Networks

OpenAIRE

Jia Xu; Xin Feng; Wen Jun Yang; Ru Chuan Wang; Bing Qing Han

2013-01-01

Multicopy forwarding schemes have been employed in delay tolerant network (DTN) to improve the delivery delay and delivery rate. Much effort has been focused on reducing the routing cost while retaining high performance. This paper aims to provide an optimal joint expected delay forwarding (OJEDF) protocol which minimizes the expected delay while satisfying a certain constant on the number of forwardings per message. We propose a comprehensive forwarding metric called joint expected delay (JE...

THE STRUCTURE OF THE BROAD-LINE REGION IN ACTIVE GALACTIC NUCLEI. I. RECONSTRUCTED VELOCITY-DELAY MAPS

International Nuclear Information System (INIS)

Grier, C. J.; Peterson, B. M.; Pogge, R. W.; De Rosa, G.; Martini, Paul; Kochanek, C. S.; Zu, Y.; Shappee, B.; Beatty, T. G.; Salvo, C. Araya; Bird, J. C.; Horne, Keith; Bentz, M. C.; Denney, K. D.; Siverd, R.; Sergeev, S. G.; Borman, G. A.; Kaspi, S.; Bord, D. J.; Che, X.

2013-01-01

We present velocity-resolved reverberation results for five active galactic nuclei. We recovered velocity-delay maps using the maximum entropy method for four objects: Mrk 335, Mrk 1501, 3C 120, and PG 2130+099. For the fifth, Mrk 6, we were only able to measure mean time delays in different velocity bins of the Hβ emission line. The four velocity-delay maps show unique dynamical signatures for each object. For 3C 120, the Balmer lines show kinematic signatures consistent with both an inclined disk and infalling gas, but the He II λ4686 emission line is suggestive only of inflow. The Balmer lines in Mrk 335, Mrk 1501, and PG 2130+099 show signs of infalling gas, but the He II emission in Mrk 335 is consistent with an inclined disk. We also see tentative evidence of combined virial motion and infalling gas from the velocity-binned analysis of Mrk 6. The maps for 3C 120 and Mrk 335 are two of the most clearly defined velocity-delay maps to date. These maps constitute a large increase in the number of objects for which we have resolved velocity-delay maps and provide evidence supporting the reliability of reverberation-based black hole mass measurements.

THE STRUCTURE OF THE BROAD-LINE REGION IN ACTIVE GALACTIC NUCLEI. I. RECONSTRUCTED VELOCITY-DELAY MAPS

Energy Technology Data Exchange (ETDEWEB)

Grier, C. J.; Peterson, B. M.; Pogge, R. W.; De Rosa, G.; Martini, Paul; Kochanek, C. S.; Zu, Y.; Shappee, B.; Beatty, T. G.; Salvo, C. Araya; Bird, J. C. [Department of Astronomy, The Ohio State University, 140 W 18th Ave, Columbus, OH 43210 (United States); Horne, Keith [SUPA Physics and Astronomy, University of St. Andrews, Fife, KY16 9SS Scotland (United Kingdom); Bentz, M. C. [Department of Physics and Astronomy, Georgia State University, Astronomy Offices, One Park Place South SE, Suite 700, Atlanta, GA 30303 (United States); Denney, K. D. [Marie Curie Fellow at the Dark Cosmology Centre, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, DK-2100 Copenhagen (Denmark); Siverd, R. [Department of Physics and Astronomy, Vanderbilt University, 5301 Stevenson Center, Nashville, TN 37235 (United States); Sergeev, S. G.; Borman, G. A. [Crimean Astrophysical Observatory, P/O Nauchny Crimea 98409 (Ukraine); Kaspi, S. [School of Physics and Astronomy, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978 (Israel); Bord, D. J. [Department of Natural Sciences, The University of Michigan - Dearborn, 4901 Evergreen Rd, Dearborn, MI 48128 (United States); Che, X. [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 41809 (United States); and others

2013-02-10

We present velocity-resolved reverberation results for five active galactic nuclei. We recovered velocity-delay maps using the maximum entropy method for four objects: Mrk 335, Mrk 1501, 3C 120, and PG 2130+099. For the fifth, Mrk 6, we were only able to measure mean time delays in different velocity bins of the H{beta} emission line. The four velocity-delay maps show unique dynamical signatures for each object. For 3C 120, the Balmer lines show kinematic signatures consistent with both an inclined disk and infalling gas, but the He II {lambda}4686 emission line is suggestive only of inflow. The Balmer lines in Mrk 335, Mrk 1501, and PG 2130+099 show signs of infalling gas, but the He II emission in Mrk 335 is consistent with an inclined disk. We also see tentative evidence of combined virial motion and infalling gas from the velocity-binned analysis of Mrk 6. The maps for 3C 120 and Mrk 335 are two of the most clearly defined velocity-delay maps to date. These maps constitute a large increase in the number of objects for which we have resolved velocity-delay maps and provide evidence supporting the reliability of reverberation-based black hole mass measurements.

Delays in the management of retroperitoneal sarcomas

DEFF Research Database (Denmark)

Seinen, Jojanneke; Almquist, Martin; Styring, Emelie

2010-01-01

Retroperitoneal sarcomas are rare and treatment should optimally be centralized. Despite successful centralization with 90% of the patients referred prior to surgery, delays occur, which led us to assess lead times in a population-based series. Method. Patients diagnosed with retroperitoneal...... sarcoma in the southern Sweden health care region 2003-2009 were eligible for the study. Data on referrals and diagnostic investigations were collected from clinical files from primary health care, local hospitals, and from the sarcoma centre. Lead times were divided into patient delays and health care...... at the general practitioner, 36 days at local hospitals, and 55 days at the sarcoma centre. Conclusion. Centralization per se is not sufficient for optimized and efficient management. Our findings suggest that delays can be minimized by direct referral of patients from primary health care to sarcoma centers...

Age differences in striatal delay sensitivity during intertemporal choice in healthy adults

Directory of Open Access Journals (Sweden)

Gregory R Samanez-Larkin

2011-11-01

Full Text Available Intertemporal choices are a ubiquitous class of decisions that involve selecting between outcomes available at different times in the future. We investigated the neural systems supporting intertemporal decisions in healthy younger and older adults. Using functional neuroimaging, we find that aging is associated with a shift in the brain areas that respond to delayed rewards. Although we replicate findings that brain regions associated with the mesolimbic dopamine system respond preferentially to immediate rewards, we find a separate region in the ventral striatum with very modest time dependence in older adults. Activation in this striatal region was relatively insensitive to delay in older but not younger adults. Since the dopamine system is believed to support associative learning about future rewards over time, our observed transfer of function may be due to greater experience with delayed rewards as people age. Identifying differences in the neural systems underlying these decisions may contribute to a more comprehensive model of age-related change in intertemporal choice.

Stability criteria for neutral delay differential-algebraic equations

Directory of Open Access Journals (Sweden)

FAN Ni

2013-10-01

Full Text Available The asymptotic stability of neutral delay differential-algebraic equations is studied in this paper.Two stability criteria described by evaluating a corresponding harmonic function on the boundary of a torus region are presented.

Delay-induced wave instabilities in single-species reaction-diffusion systems

Science.gov (United States)

Otto, Andereas; Wang, Jian; Radons, Günter

2017-11-01

The Turing (wave) instability is only possible in reaction-diffusion systems with more than one (two) components. Motivated by the fact that a time delay increases the dimension of a system, we investigate the presence of diffusion-driven instabilities in single-species reaction-diffusion systems with delay. The stability of arbitrary one-component systems with a single discrete delay, with distributed delay, or with a variable delay is systematically analyzed. We show that a wave instability can appear from an equilibrium of single-species reaction-diffusion systems with fluctuating or distributed delay, which is not possible in similar systems with constant discrete delay or without delay. More precisely, we show by basic analytic arguments and by numerical simulations that fast asymmetric delay fluctuations or asymmetrically distributed delays can lead to wave instabilities in these systems. Examples, for the resulting traveling waves are shown for a Fisher-KPP equation with distributed delay in the reaction term. In addition, we have studied diffusion-induced instabilities from homogeneous periodic orbits in the same systems with variable delay, where the homogeneous periodic orbits are attracting resonant periodic solutions of the system without diffusion, i.e., periodic orbits of the Hutchinson equation with time-varying delay. If diffusion is introduced, standing waves can emerge whose temporal period is equal to the period of the variable delay.

The structure of the broad-line region in active galactic nuclei. I. Reconstructed velocity-delay maps

DEFF Research Database (Denmark)

Grier, C.J.; Peterson, B.M.; Pogge, R.W.

2013-01-01

We present velocity-resolved reverberation results for five active galactic nuclei. We recovered velocity-delay maps using the maximum entropy method for four objects: Mrk 335, Mrk 1501, 3C 120, and PG 2130+099. For the fifth, Mrk 6, we were only able to measure mean time delays in different velo...

Microdeletion/microduplication of proximal 15q11.2 between BP1 and BP2: a susceptibility region for neurological dysfunction including developmental and language delay.

Science.gov (United States)

Burnside, Rachel D; Pasion, Romela; Mikhail, Fady M; Carroll, Andrew J; Robin, Nathaniel H; Youngs, Erin L; Gadi, Inder K; Keitges, Elizabeth; Jaswaney, Vikram L; Papenhausen, Peter R; Potluri, Venkateswara R; Risheg, Hiba; Rush, Brooke; Smith, Janice L; Schwartz, Stuart; Tepperberg, James H; Butler, Merlin G

2011-10-01

The proximal long arm of chromosome 15 has segmental duplications located at breakpoints BP1-BP5 that mediate the generation of NAHR-related microdeletions and microduplications. The classical Prader-Willi/Angelman syndrome deletion is flanked by either of the proximal BP1 or BP2 breakpoints and the distal BP3 breakpoint. The larger Type I deletions are flanked by BP1 and BP3 in both Prader-Willi and Angelman syndrome subjects. Those with this deletion are reported to have a more severe phenotype than individuals with either Type II deletions (BP2-BP3) or uniparental disomy 15. The BP1-BP2 region spans approximately 500 kb and contains four evolutionarily conserved genes that are not imprinted. Reports of mutations or disturbed expression of these genes appear to impact behavioral and neurological function in affected individuals. Recently, reports of deletions and duplications flanked by BP1 and BP2 suggest an association with speech and motor delays, behavioral problems, seizures, and autism. We present a large cohort of subjects with copy number alteration of BP1 to BP2 with common phenotypic features. These include autism, developmental delay, motor and language delays, and behavioral problems, which were present in both cytogenetic groups. Parental studies demonstrated phenotypically normal carriers in several instances, and mildly affected carriers in others, complicating phenotypic association and/or causality. Possible explanations for these results include reduced penetrance, altered gene dosage on a particular genetic background, or a susceptibility region as reported for other areas of the genome implicated in autism and behavior disturbances.

Stability and delay sensitivity of neutral fractional-delay systems.

Science.gov (United States)

Xu, Qi; Shi, Min; Wang, Zaihua

2016-08-01

This paper generalizes the stability test method via integral estimation for integer-order neutral time-delay systems to neutral fractional-delay systems. The key step in stability test is the calculation of the number of unstable characteristic roots that is described by a definite integral over an interval from zero to a sufficient large upper limit. Algorithms for correctly estimating the upper limits of the integral are given in two concise ways, parameter dependent or independent. A special feature of the proposed method is that it judges the stability of fractional-delay systems simply by using rough integral estimation. Meanwhile, the paper shows that for some neutral fractional-delay systems, the stability is extremely sensitive to the change of time delays. Examples are given for demonstrating the proposed method as well as the delay sensitivity.

Risk analysis of the delayed ettringite formation in pile caps foundation in the metropolitan region of Recife - PE - Brasil

Directory of Open Access Journals (Sweden)

I. F. Torres

Full Text Available ABSTRACT Currently, there is an awareness that is critical to assess the durability characteristics of concrete with as much attention as the mechanical properties. The durability of concrete structures can often be affected by chemical attacks, jeopardizing its performance and security. When concrete is subjected to high temperature at early ages, many physical and chemical changes in hardened concrete may occur. It iswidely accepted that concrete subjected to these conditions of temperature and exposed to moisture is prone to cracking due to Delayed Ettringite Formation (DEF. This work aims at providing a DEF risk analysis on foundation pile caps at the Metropolitan Region of Recife - PE. Temperature rise measurement was performed in situ at 5 different caps through datalogger and thermocouples equipments. Furthermore, the Duggan test was performed in order to assess the level of expansion of 3 cements studied: X (CP II E 40, Y (CP II F 32 and Z (CP V ARI RS. Simultaneously, the chemical compositions of these cements and their respective clinkers were quantified by analysis of X-ray fluorescence (XRF. The cement X (CP II E 40 showed the chemical characteristics favoring with more intensity DEF and, as a result, higher level of expansion in the test Duggan. It is noteworthy that incorporation of metakaolin (8% and 16% and silica fume (5% and 10% showed mitigating potential of expansions. It is important to point out that all factors related to thermal properties and chemical composition of the concrete used in the region converge to a condition of ideal susceptibility for triggering DEF. Therefore, it is essential at least minimum and basic requirements in the design specification in order to avoid high temperatures in the massive concrete elements, preventing them from delayed ettringite formation.

Editorial Commentary: "Defer No Time, Delays Have Dangerous Ends" (Henry VI, Shakespeare): Delayed Anterior Cruciate Ligament Reconstruction Has Consequences.

Science.gov (United States)

Siegel, Mark G

2018-06-01

There continues to be controversy over the timing of anterior cruciate ligament (ACL) surgery. Early or delayed intervention after ACL injury is a topic that has not been settled. The issue is whether ACL tears should have surgery performed in an expedient manner. Or is delay an option with no repercussions to the health of the knee? My associates in nonsurgical specialties wave the New England Journal of Medicine to support their view that surgery is not needed. I routinely espouse the literature confirming that delay of surgery may cause future damage. It is now established that a failure to intervene in a timely manner does cause additional damage. I stand vindicated and can affirm to my colleagues that I have found the answer. There is no longer any doubt or equivocation. Delay in reconstructing an unstable knee does cause damage. Copyright © 2018 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

Improved visualization of delayed perfusion in lung MRI

International Nuclear Information System (INIS)

Risse, Frank; Eichinger, Monika; Kauczor, Hans-Ulrich; Semmler, Wolfhard; Puderbach, Michael

2011-01-01

Introduction: The investigation of pulmonary perfusion by three-dimensional (3D) dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was proposed recently. Subtraction images are generated for clinical evaluation, but temporal information is lost and perfusion defects might therefore be masked in this process. The aim of this study is to demonstrate a simple analysis strategy and classification for 3D-DCE-MRI perfusion datasets in the lung without omitting the temporal information. Materials and methods: Pulmonary perfusion measurements were performed in patients with different lung diseases using a 1.5 T MR-scanner with a time-resolved 3D-GRE pulse sequence. 25 3D-volumes were acquired after iv-injection of 0.1 mmol/kg KG Gadolinium-DTPA. Three parameters were determined for each pixel: (1) peak enhancement S n,max normalized to the arterial input function to detect regions of reduced perfusion; (2) time between arterial peak enhancement in the large pulmonary artery and tissue peak enhancement τ to visualize regions with delayed bolus onset; and (3) ratio R = S n,max /τ was calculated to visualize impaired perfusion, irrespectively of whether related to reduced or delayed perfusion. Results: A manual selection of peak perfusion images is not required. Five different types of perfusion can be found: (1) normal perfusion; (2) delayed non-reduced perfusion; (3) reduced non-delayed perfusion; (4) reduced and delayed perfusion; and (5) no perfusion. Types II and IV could not be seen in subtraction images since the temporal information is necessary for this purpose. Conclusions: The analysis strategy in this study allows for a simple and observer-independent visualization and classification of impaired perfusion in dynamic contrast-enhanced pulmonary perfusion MRI by using the temporal information of the datasets.

Time delay induced different synchronization patterns in repulsively coupled chaotic oscillators

Science.gov (United States)

Yao, Chenggui; Yi, Ming; Shuai, Jianwei

2013-09-01

Time delayed coupling plays a crucial role in determining the system's dynamics. We here report that the time delay induces transition from the asynchronous state to the complete synchronization (CS) state in the repulsively coupled chaotic oscillators. In particular, by changing the coupling strength or time delay, various types of synchronous patterns, including CS, antiphase CS, antiphase synchronization (ANS), and phase synchronization, can be generated. In the transition regions between different synchronous patterns, bistable synchronous oscillators can be observed. Furthermore, we show that the time-delay-induced phase flip bifurcation is of key importance for the emergence of CS. All these findings may light on our understanding of neuronal synchronization and information processing in the brain.

Diagnostic and treatment delay among pulmonary tuberculosis patients in Ethiopia: a cross sectional study

Directory of Open Access Journals (Sweden)

Yimer Solomon

2005-12-01

Full Text Available Abstract Background Delayed diagnosis and treatment of tuberculosis (TB results in severe disease and a higher mortality. It also leads to an increased period of infectivity in the community. The objective of this study was to determine the length of delays, and analyze the factors affecting the delay from onset of symptoms of pulmonary tuberculosis (PTB until the commencement of treatment. Methods In randomly selected TB management units (TBMUs, i.e. government health institutions which have diagnosing and treatment facilities for TB in Amhara Region, we conducted a cross sectional study from September 1-December 31/2003. Delay was analyzed from two perspectives, 1. Period between onset of TB symptoms to first visit to any health provider (health seeking period, and from the first health provider visit to initiation of treatment (health providers' delay, and 2. Period between onset of TB symptoms to first visit to a medical provider (patients' delay, and from this visit to commencement of anti-TB treatment (health systems' delay. Patients were interviewed on the same date of diagnosis using a semi-structured questionnaire. Logistics regression analysis was applied to analyze the risk factors of delays. Results A total of 384 new smear positive PTB patients participated in the study. The median total delay was 80 days. The median health-seeking period and health providers' delays were 15 and 61 days, respectively. Conversely, the median patients' and health systems' delays were 30 and 21 days, respectively. Taking medical providers as a reference point, we found that forty eight percent of the subjects delayed for more than one month. Patients' delays were strongly associated with first visit to non-formal health providers and self treatment (P Conclusion Delay in the diagnosis and treatment of PTB is unacceptably high in Amhara region. Health providers' and health systems' delays represent the major portion of the total delay. Accessing a

Indigenous mothers face more than three delays: The challenges of multiculturalism in health

Directory of Open Access Journals (Sweden)

Roosta-G., Manigeh

2015-08-01

Full Text Available Although the maternal mortality ratio has descended in Bolivia from 416 (1989 to 229 deaths (DHS 2003 per one hundred thousand live births, it is one of the highest in the region. As a national average, the ratio conceals the rural-urban, socio-economics differences and the reality of the indigenous population. Maternal mortality is one of the major challenges at national level. Reduction of maternal mortality, in addition of technical-medical measures offering health services, requires to focus on socio-cultural aspects that hamper the access to health services. This article examines challenges faced by indigenous mothers accessing the health services. In addition to the geographic, economic and administrative barriers that generate delays in access to the health services, there are others that are presented in the context of multiculturalism resulting from discriminatory attitudes exercised in health centers. The testimonies of indigenous mothers show delays faced in health centers because of prejudice and discrimination suffered, threatening the lives of mothers and their babies. The study also suggests the need to deepen the concept of multiculturalism as a successful strategy in health, in order to promote equity and social justice on the horizon of more inclusive societies.

Impact of delays to cardiac surgery after failed angioplasty and stenting.

Science.gov (United States)

Lotfi, Mat; Mackie, Karen; Dzavik, Vladimir; Seidelin, Peter H

2004-02-04

This study was designed to determine the likelihood of harm in patients having additional delays before urgent coronary artery bypass graft (UCABG) surgery after percutaneous coronary intervention (PCI). Patients who have PCI at hospitals without cardiac surgery have additional delays to surgery when UCABG is indicated. Detailed chart review was performed on all patients who had a failed PCI leading to UCABG at a large tertiary care hospital. A prespecified set of criteria (hemodynamic instability, coronary perforation with significant effusion or tamponade, or severe ischemia) was used to identify patients who would have an increased likelihood of harm with additional delays to surgery. From 1996 to 2000, 6,582 PCIs were performed. There were 45 patients (0.7%) identified to have UCABG. The demographic characteristics of the UCABG patients were similar to the rest of the patients in the PCI database, except for significantly more type C lesions (45.3% vs. 25.0%, p surgery. The absolute risk of harm is approximately one to two patients per 1,000 PCIs. Approximately one in four patients referred for UCABG would be placed at increased risk of harm if delays to surgery were encountered.

Introduction to Focus Issue: Time-delay dynamics

Science.gov (United States)

Erneux, Thomas; Javaloyes, Julien; Wolfrum, Matthias; Yanchuk, Serhiy

2017-11-01

The field of dynamical systems with time delay is an active research area that connects practically all scientific disciplines including mathematics, physics, engineering, biology, neuroscience, physiology, economics, and many others. This Focus Issue brings together contributions from both experimental and theoretical groups and emphasizes a large variety of applications. In particular, lasers and optoelectronic oscillators subject to time-delayed feedbacks have been explored by several authors for their specific dynamical output, but also because they are ideal test-beds for experimental studies of delay induced phenomena. Topics include the control of cavity solitons, as light spots in spatially extended systems, new devices for chaos communication or random number generation, higher order locking phenomena between delay and laser oscillation period, and systematic bifurcation studies of mode-locked laser systems. Moreover, two original theoretical approaches are explored for the so-called Low Frequency Fluctuations, a particular chaotical regime in laser output which has attracted a lot of interest for more than 30 years. Current hot problems such as the synchronization properties of networks of delay-coupled units, novel stabilization techniques, and the large delay limit of a delay differential equation are also addressed in this special issue. In addition, analytical and numerical tools for bifurcation problems with or without noise and two reviews on concrete questions are proposed. The first review deals with the rich dynamics of simple delay climate models for El Nino Southern Oscillations, and the second review concentrates on neuromorphic photonic circuits where optical elements are used to emulate spiking neurons. Finally, two interesting biological problems are considered in this Focus Issue, namely, multi-strain epidemic models and the interaction of glucose and insulin for more effective treatment.

Emergency surgery pre-operative delays - realities and economic impacts.

Science.gov (United States)

O'Leary, D P; Beecher, S; McLaughlin, R

2014-12-01

A key principle of acute surgical service provision is the establishment of a distinct patient flow process and an emergency theatre. Time-to-theatre (TTT) is a key performance indicator of theatre efficiency. The combined impacts of an aging population, increasing demands and complexity associated with centralisation of emergency and oncology services has placed pressure on emergency theatre access. We examined our institution's experience with running a designated emergency theatre for acute surgical patients. A retrospective review of an electronic prospectively maintained database was performed between 1/1/12 and 31/12/13. A cost analysis was conducted to assess the economic impact of delayed TTT, with every 24hr delay incurring the cost of an additional overnight bed. Delays and the economic effects were assessed only after the first 24 h as an in-patient had elapsed. In total, 7041 procedures were performed. Overall mean TTT was 26 h, 2 min. There were significant differences between different age groups, with those aged under 16 year and over 65 having mean TTT at 6 h, 34 min (95% C.I. 0.51-2.15, p 65 years age group had a mean TTT of 23 h, 41 min which was significantly longer than the overall mean TTT Vascular and urological emergencies are significantly disadvantaged in competition with other services for a shared emergency theatre. The economic impact of delayed TTT was calculated at €7,116,000, or €9880/day of additional costs generated from delayed TTT over a 24 month period. One third of patients waited longer than 24 h for emergency surgery, with the elderly disproportionately represented in this group. Aside from the clinical risks of delayed and out of hours surgery, such practices incur significant additional costs. New strategies must be devised to ensure efficient access to emergency theatres, investment in such services is likely to be financially and clinically beneficial. Copyright © 2014 Surgical Associates Ltd. Published by Elsevier

Fundamental Matrix for a Class of Point Delay Linear Systems

International Nuclear Information System (INIS)

Sen, M. de la; Alastruey, C. F.

1998-01-01

It is difficult to establish explicit analytic forms for fundamental matrices of delayed linear systems. In this paper, an explicit form of exponential type is given for such a matrix in the case of punctual delays. The existence of real and complex fundamental matrices, for the case of real parameterizations of the differential system, is studied and discussed. Some additional commutativity properties involving the matrices parameters and the fundamental matrices as well as explicit expressions for the solution of the delayed differential system are also given. (Author)

Stochastic resonance in a time-delayed asymmetric bistable system with mixed periodic signal

International Nuclear Information System (INIS)

Yong-Feng, Guo; Wei, Xu; Liang, Wang

2010-01-01

This paper studies the phenomenon of stochastic resonance in an asymmetric bistable system with time-delayed feedback and mixed periodic signal by using the theory of signal-to-noise ratio in the adiabatic limit. A general approximate Fokker–Planck equation and the expression of the signal-to-noise ratio are derived through the small time delay approximation at both fundamental harmonics and mixed harmonics. The effects of the additive noise intensity Q, multiplicative noise intensity D, static asymmetry r and delay time τ on the signal-to-noise ratio are discussed. It is found that the higher mixed harmonics and the static asymmetry r can restrain stochastic resonance, and the delay time τ can enhance stochastic resonance. Moreover, the longer the delay time τ is, the larger the additive noise intensity Q and the multiplicative noise intensity D are, when the stochastic resonance appears. (general)

Variability of wet troposphere delays over inland reservoirs as simulated by a high-resolution regional climate model

Science.gov (United States)

Clark, E.; Lettenmaier, D. P.

2014-12-01

Satellite radar altimetry is widely used for measuring global sea level variations and, increasingly, water height variations of inland water bodies. Existing satellite radar altimeters measure water surfaces directly below the spacecraft (approximately at nadir). Over the ocean, most of these satellites use radiometry to measure the delay of radar signals caused by water vapor in the atmosphere (also known as the wet troposphere delay (WTD)). However, radiometry can only be used to estimate this delay over the largest inland water bodies, such as the Great Lakes, due to spatial resolution issues. As a result, atmospheric models are typically used to simulate and correct for the WTD at the time of observations. The resolutions of these models are quite coarse, at best about 5000 km2 at 30˚N. The upcoming NASA- and CNES-led Surface Water and Ocean Topography (SWOT) mission, on the other hand, will use interferometric synthetic aperture radar (InSAR) techniques to measure a 120-km-wide swath of the Earth's surface. SWOT is expected to make useful measurements of water surface elevation and extent (and storage change) for inland water bodies at spatial scales as small as 250 m, which is much smaller than current altimetry targets and several orders of magnitude smaller than the models used for wet troposphere corrections. Here, we calculate WTD from very high-resolution (4/3-km to 4-km) simulations of the Weather Research and Forecasting (WRF) regional climate model, and use the results to evaluate spatial variations in WTD. We focus on six U.S. reservoirs: Lake Elwell (MT), Lake Pend Oreille (ID), Upper Klamath Lake (OR), Elephant Butte (NM), Ray Hubbard (TX), and Sam Rayburn (TX). The reservoirs vary in climate, shape, use, and size. Because evaporation from open water impacts local water vapor content, we compare time series of WTD over land and water in the vicinity of each reservoir. To account for resolution effects, we examine the difference in WRF

Effect of Nb on hydrogen-induced delayed fracture in high strength hot stamping steels

Energy Technology Data Exchange (ETDEWEB)

Zhang, Shiqi [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); College of Mechanical Engineering, Yangtze University, Jingzhou 434023 (China); Huang, Yunhua, E-mail: huangyh@mater.ustb.edu.cn [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Sun, Bintang, E-mail: bingtangsun@ustb.edu.cn [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Liao, Qingliang [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); Lu, Hongzhou [CITIC Metal Co. Ltd., Room 1901, Capital Mansion 6, Xin Yuan Nanlu, Chaoyang District, Beijing 100004 (China); The School of Resources and Environmental Engineering, East China University of Science and Technology, Meilong road 130, Xujiahui District, Shanghai 200237 (China); Jian, Bian [Niobium Tech Asia, 068898 Singapore (Singapore); Mohrbacher, Hardy [NiobelCon bvba, 2970 Schilde (Belgium); Zhang, Wei; Guo, Aimin [CITIC Metal Co. Ltd., Room 1901, Capital Mansion 6, Xin Yuan Nanlu, Chaoyang District, Beijing 100004 (China); Zhang, Yue [School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083 (China); The State Key Laboratory for Advanced Metals and Materials, University of Science and Technology Beijing, Beijing 100083 (China)

2015-02-25

The effect of Nb addition (0.022, 0.053, 0.078 wt%) on the hydrogen-induced delayed fracture resistance of 22MnB5 was studied by constant load test and electrochemical hydrogen permeation method. It is shown that the appropriate addition of Nb is beneficial to the improvement of the delayed fracture resistance of tested steel, especially when the steel contains high concentration of hydrogen, and the maximum delayed fracture resistance is obtained at a Nb content of 0.053%.The result of hydrogen permeation test shows that the diffusion coefficient of hydrogen in the steel containing niobium is lower than that in steel without niobium, which indicates that it is harder for hydrogen in the steels containing niobium to diffuse and aggregate. In addition, the reason for Nb improving the delayed fracture resistance of steels is discussed from two aspects: hydrogen trap effect and grain refinement effect. The analysis shows that the main reason leading to the improvement of the delayed fracture resistance is the hydrogen trapping effect of NbC while the grain refinement effect of Nb(C,N) secondary.

Effect of Nb on hydrogen-induced delayed fracture in high strength hot stamping steels

International Nuclear Information System (INIS)

Zhang, Shiqi; Huang, Yunhua; Sun, Bintang; Liao, Qingliang; Lu, Hongzhou; Jian, Bian; Mohrbacher, Hardy; Zhang, Wei; Guo, Aimin; Zhang, Yue

2015-01-01

The effect of Nb addition (0.022, 0.053, 0.078 wt%) on the hydrogen-induced delayed fracture resistance of 22MnB5 was studied by constant load test and electrochemical hydrogen permeation method. It is shown that the appropriate addition of Nb is beneficial to the improvement of the delayed fracture resistance of tested steel, especially when the steel contains high concentration of hydrogen, and the maximum delayed fracture resistance is obtained at a Nb content of 0.053%.The result of hydrogen permeation test shows that the diffusion coefficient of hydrogen in the steel containing niobium is lower than that in steel without niobium, which indicates that it is harder for hydrogen in the steels containing niobium to diffuse and aggregate. In addition, the reason for Nb improving the delayed fracture resistance of steels is discussed from two aspects: hydrogen trap effect and grain refinement effect. The analysis shows that the main reason leading to the improvement of the delayed fracture resistance is the hydrogen trapping effect of NbC while the grain refinement effect of Nb(C,N) secondary

Posttraumatic Stress, Coping Flexibility, and Risky Drinking Among Trauma-Exposed Male and Female College Students: The Mediating Effect of Delay of Gratification.

Science.gov (United States)

Boyraz, Güler; Cherry, Megan L; Cherry, Marcus A; Aarstad-Martin, Samantha; Cloud, Cody; Shamp, Lindsey M

2018-02-23

The co-occurence of posttraumatic stress (PTS) and risky drinking has been demonstrated in diverse populations, including college students. However, the mechanisms underlying this co-occurrence, as well as the protective factors that may reduce risky drinking among trauma-exposed college students have yet to be fully understood in the literature. The present study builds upon self-regulation theories and previous empirical work to determine whether the effects of PTS and coping flexibility on risky drinking were mediated by delay of gratification among trauma-exposed college students. In addition, the potential moderating effect of gender on these relationships was examined. Participants included 624 trauma-exposed college students (68.4% female) attending a public university in the southeast region of the United States. Data were collected through an online survey. The hypothesized model was examined using a multigroup structural equation modeling approach. As hypothesized, PTS had a significant, positive indirect effect on risky drinking through delay of gratification; however, the effect of PTS on delay of gratification was stronger for males than for females. Results also indicated that the indirect effect of coping flexibility on risky drinking through delay of gratification was significant and negative for males and females. Conclusions/Importance: The findings of this study suggest that delay of gratification might be an important mechanism underlying the co-occurrence of PTS and risky drinking. In addition, our results highlight the potential benefits of coping flexibility for college students coping with PTS.

Polar Cooperative Navigation Algorithm for Multi-Unmanned Underwater Vehicles Considering Communication Delays

Directory of Open Access Journals (Sweden)

Zheping Yan

2018-03-01

Full Text Available To solve the navigation accuracy problems of multi-Unmanned Underwater Vehicles (multi-UUVs in the polar region, a polar cooperative navigation algorithm for multi-UUVs considering communication delays is proposed in this paper. UUVs are important pieces of equipment in ocean engineering for marine development. For UUVs to complete missions, precise navigation is necessary. It is difficult for UUVs to establish true headings because of the rapid convergence of Earth meridians and the severe polar environment. Based on the polar grid navigation algorithm, UUV navigation in the polar region can be accomplished with the Strapdown Inertial Navigation System (SINS in the grid frame. To save costs, a leader-follower type of system is introduced in this paper. The leader UUV helps the follower UUVs to achieve high navigation accuracy. Follower UUVs correct their own states based on the information sent by the leader UUV and the relative position measured by ultra-short baseline (USBL acoustic positioning. The underwater acoustic communication delay is quantized by the model. In this paper, considering underwater acoustic communication delay, the conventional adaptive Kalman filter (AKF is modified to adapt to polar cooperative navigation. The results demonstrate that the polar cooperative navigation algorithm for multi-UUVs that considers communication delays can effectively navigate the sailing of multi-UUVs in the polar region.

Stability and bifurcation analysis of a generalized scalar delay differential equation.

Science.gov (United States)

Bhalekar, Sachin

2016-08-01

This paper deals with the stability and bifurcation analysis of a general form of equation D(α)x(t)=g(x(t),x(t-τ)) involving the derivative of order α ∈ (0, 1] and a constant delay τ ≥ 0. The stability of equilibrium points is presented in terms of the stability regions and critical surfaces. We provide a necessary condition to exist chaos in the system also. A wide range of delay differential equations involving a constant delay can be analyzed using the results proposed in this paper. The illustrative examples are provided to explain the theory.

Optimal state estimation over communication channels with random delays

KAUST Repository

Mahmoud, Magdi S.; Liu, Bo

2013-01-01

This paper is concerned with the optimal estimation of linear systems over unreliable communication channels with random delays. The measurements are delivered without time stamp, and the probabilities of time delays are assumed to be known. Since the estimation is time-driven, the actual time delays are converted into virtual time delays among the formulation. The receiver of estimation node stores the sum of arrived measurements between two adjacent processing time instants and also counts the number of arrived measurements. The original linear system is modeled as an extended system with uncertain observation to capture the feature of communication, then the optimal estimation algorithm of systems with uncertain observations is proposed. Additionally, a numerical simulation is presented to show the performance of this work. © 2013 The Franklin Institute.

Optimal state estimation over communication channels with random delays

KAUST Repository

Mahmoud, Magdi S.

2013-04-01

This paper is concerned with the optimal estimation of linear systems over unreliable communication channels with random delays. The measurements are delivered without time stamp, and the probabilities of time delays are assumed to be known. Since the estimation is time-driven, the actual time delays are converted into virtual time delays among the formulation. The receiver of estimation node stores the sum of arrived measurements between two adjacent processing time instants and also counts the number of arrived measurements. The original linear system is modeled as an extended system with uncertain observation to capture the feature of communication, then the optimal estimation algorithm of systems with uncertain observations is proposed. Additionally, a numerical simulation is presented to show the performance of this work. © 2013 The Franklin Institute.

Delay Estimator and Improved Proportionate Multi-Delay Adaptive Filtering Algorithm

Directory of Open Access Journals (Sweden)

E. Verteletskaya

2012-04-01

Full Text Available This paper pertains to speech and acoustic signal processing, and particularly to a determination of echo path delay and operation of echo cancellers. To cancel long echoes, the number of weights in a conventional adaptive filter must be large. The length of the adaptive filter will directly affect both the degree of accuracy and the convergence speed of the adaptation process. We present a new adaptive structure which is capable to deal with multiple dispersive echo paths. An adaptive filter according to the present invention includes means for storing an impulse response in a memory, the impulse response being indicative of the characteristics of a transmission line. It also includes a delay estimator for detecting ranges of samples within the impulse response having relatively large distribution of echo energy. These ranges of samples are being indicative of echoes on the transmission line. An adaptive filter has a plurality of weighted taps, each of the weighted taps having an associated tap weight value. A tap allocation/control circuit establishes the tap weight values in response to said detecting means so that only taps within the regions of relatively large distributions of echo energy are turned on. Thus, the convergence speed and the degree of estimation in the adaptation process can be improved.

Noise transmission and delay-induced stochasticoscillations in biochemical network motifs

Institute of Scientific and Technical Information of China (English)

Liu Sheng-Jun; Wang Qi; Liu Bo; Yan Shi-Wei; Fumihiko Sakata

2011-01-01

With the aid of stochastic delayed-feedback differential equations,we derive an analytic expression for the power spectra of reacting molecules included in a generic biological network motif that is incorporated with a feedback mechanism and time delays in gene regulation.We systematically analyse the effects of time delays,the feedback mechanism,and biological stochasticity on the power spectra.It has been clarified that the time delays together with the feedback mechanism can induce stochastic oscillations at the molecular level and invalidate the noise addition rule for a modular description of the noise propagator.Delay-induced stochastic resonance can be expected,which is related to the stability loss of the reaction systems and Hopf bifurcation occurring for solutions of the corresponding deterministic reaction equations.Through the analysis of the power spectrum,a new approach is proposed to estimate the oscillation period.

Long-time behavior for suspension bridge equations with time delay

Science.gov (United States)

Park, Sun-Hye

2018-04-01

In this paper, we consider suspension bridge equations with time delay of the form u_{tt}(x,t) + Δ ^2 u (x,t) + k u^+ (x,t) + a_0 u_t (x,t) + a_1 u_t (x, t- τ ) + f(u(x,t)) = g(x). Many researchers have studied well-posedness, decay rates of energy, and existence of attractors for suspension bridge equations without delay effects. But, as far as we know, there is no work about suspension equations with time delay. In addition, there are not many studies on attractors for other delayed systems. Thus we first provide well-posedness for suspension equations with time delay. And then show the existence of global attractors and the finite dimensionality of the attractors by establishing energy functionals which are related to the norm of the phase space to our problem.

Fuzzy delay model based fault simulator for crosstalk delay fault test ...

Indian Academy of Sciences (India)

In this paper, a fuzzy delay model based crosstalk delay fault simulator is proposed. As design trends move towards nanometer technologies, more number of new parameters affects the delay of the component. Fuzzy delay models are ideal for modelling the uncertainty found in the design and manufacturing steps.

Flight delay performance at Hartsfield-Jackson Atlanta International Airport

Directory of Open Access Journals (Sweden)

Grigoriy Yablonsky

2014-01-01

Full Text Available Purpose: The main objective of this paper is to determine the annual cyclical flight delays at Hartsfield-Jackson Atlanta International Airport. Then using other data such as annual precipitation, passenger and aircraft traffic volumes and other factors, we attempted to correlate these factors with overall delays. These data could assist airport management in predicting periods of flight delay.Design/methodology/approach: Data were taken and analyzed from the data base “Research and Innovation Technology Administration” (RITA for the years 2005-2011 for Hartsfield-Jackson Atlanta International Airport. The data included 2.8 million flights originating and departing from this airport. Data were also gathered from the National Oceanic and Atmospheric Administration (NOAA showing precipitation. Additional data were gathered from the FAA regarding delay causes, number and types of delays and changes to the infrastructure of ATL airportFindings: There is a repeatable annual pattern of delays at ATL that can be modeled using delay data from the Bureau of Transportation Statistics. This pattern appears to be caused primarily by the frequency and amount of precipitation that falls at ATL and by the amount of flights that arrive and depart at ATL.Originality/value: This information could assist airport operations personnel, FAA air traffic controllers and airlines in anticipating and mitigating delays at specific times of the year.

A Cucker--Smale Model with Noise and Delay

KAUST Repository

Erban, Radek

2016-08-09

A generalization of the Cucker-Smale model for collective animal behavior is investigated. The model is formulated as a system of delayed stochastic differential equations. It incorporates two additional processes which are present in animal decision making, but are often neglected in modeling: (i) stochasticity (imperfections) of individual behavior and (ii) delayed responses of individuals to signals in their environment. Sufficient conditions for flocking for the generalized Cucker-Smale model are derived by using a suitable Lyapunov functional. As a by-product, a new result regarding the asymptotic behavior of delayed geometric Brownian motion is obtained. In the second part of the paper, results of systematic numerical simulations are presented. They not only illustrate the analytical results, but hint at a somehow surprising behavior

A Cucker--Smale Model with Noise and Delay

KAUST Repository

Erban, Radek; Haskovec, Jan; Sun, Yongzheng

2016-01-01

A generalization of the Cucker-Smale model for collective animal behavior is investigated. The model is formulated as a system of delayed stochastic differential equations. It incorporates two additional processes which are present in animal decision making, but are often neglected in modeling: (i) stochasticity (imperfections) of individual behavior and (ii) delayed responses of individuals to signals in their environment. Sufficient conditions for flocking for the generalized Cucker-Smale model are derived by using a suitable Lyapunov functional. As a by-product, a new result regarding the asymptotic behavior of delayed geometric Brownian motion is obtained. In the second part of the paper, results of systematic numerical simulations are presented. They not only illustrate the analytical results, but hint at a somehow surprising behavior

Addition of ketamine or dexmedetomidine to lignocaine in intravenous regional anesthesia: A randomized controlled study

Directory of Open Access Journals (Sweden)

Alok Kumar

2012-01-01

Results: Shortened sensory and motor block onset times (69.17 min and 7.83 min respectively, P < 0.0001 and improved quality of anesthesia (satisfaction score = 3, P < 0.05 were found in ketamine group. Visual analog scale scores (3.21 ± 0.41 were comparable while time to first analgesic requirement (166.25 ± 25.89 min, P < 0.0001 was significantly longer in dexmedetomidine group after tourniquet release. Conclusion: We conclude that the addition of 1 mcg/kg of body weight dexmedetomidine or 0.5 mg/kg of body weight ketamine to lignocaine for IVRA improves quality of anesthesia and perioperative analgesia without causing side effects. We considered ketamine reduced the time for onset of block, delayed the onset of tourniquet pain, and reduced postoperative analgesic requirement and had a better patient satisfaction than placebo or dexmedetomidine.

Delay effects in the human sensory system during balancing.

Science.gov (United States)

Stepan, Gabor

2009-03-28

Mechanical models of human self-balancing often use the Newtonian equations of inverted pendula. While these mathematical models are precise enough on the mechanical side, the ways humans balance themselves are still quite unexplored on the control side. Time delays in the sensory and motoric neural pathways give essential limitations to the stabilization of the human body as a multiple inverted pendulum. The sensory systems supporting each other provide the necessary signals for these control tasks; but the more complicated the system is, the larger delay is introduced. Human ageing as well as our actual physical and mental state affects the time delays in the neural system, and the mechanical structure of the human body also changes in a large range during our lives. The human balancing organ, the labyrinth, and the vision system essentially adapted to these relatively large time delays and parameter regions occurring during balancing. The analytical study of the simplified large-scale time-delayed models of balancing provides a Newtonian insight into the functioning of these organs that may also serve as a basis to support theories and hypotheses on balancing and vision.

Relativity time-delay experiments utilizing 'Mariner' spacecraft

Science.gov (United States)

Esposito, P. B.; Anderson, J. D.

1974-01-01

Relativity predicts that the transit time of a signal propagated from the earth to a spacecraft and retransmitted back to earth ought to exhibit an additional, variable time delay. The present work describes some of the analytical techniques employed in experiments using Mariner spacecraft designed to test the accuracy of this prediction. Two types of data are analyzed in these relativity experiments; these include phase-coherent, two-way Doppler shift and round-trip, transit-time measurements. Results of Mariner 6 and 7 relativistic time-delay experiments are in agreement with Einstein's theory of general relativity with an uncertainty of 3%.

On the cost/delay tradeoff of wireless delay tolerant geographic routing

OpenAIRE

Tasiopoulos, Argyrios; Tsiaras, Christos; Toumpis, Stavros

2012-01-01

In Delay Tolerant Networks (DTNs), there is a fundamental tradeoff between the aggregate transport cost of a packet and the delay in its delivery. We study this tradeoff in the context of geographical routing in wireless DTNs.We ?rst specify the optimal cost/delay tradeoff, i.e., the tradeoff under optimal network operation, using a dynamic network construction termed the Cost/Delay Evolving Graph (C/DEG) and the Optimal Cost/Delay Curve (OC/DC), a function that gives the minimum possible agg...

The use of CO 2 as an additive for ignition delay and pollutant control in CH 4 /air autoignition

KAUST Repository

Tingas, Efstathios Al.

2017-10-05

The effect of CO2 dilution on the adiabatic and isochoric autoignition of CH4/air mixtures is analyzed with Computational Singular Perturbation (CSP) algorithmic tools, with a particular emphasis on the determination of the features of the chemical dynamics that control ignition delay and emission formation. Increasing CO2 dilution causes longer ignition delays, lower final temperatures and decreased formation of NO and CO. These effects of CO2 dilution are shown to be entirely thermal, contrary to what happens with dilution with H2O, which also has chemical activity and can reduce ignition delay. For the same initial mole fraction of the diluent, the decrease in final temperature and in NO concentration is larger in the CO2 case whereas the decrease in CO is larger in the H2O case. The thermal effect of CO2 is entirely analogous with those of dilution with the chemically inert Ar, only stronger for the same percentage of initial dilution, because of the larger specific heat of CO2. The reactions that have the largest contribution to the characteristic explosive time scale of the system during ignition delay (H2O2(+M)→OH+OH(+M), CH3O2+CH2O→CH3O2H+HCO, CH4+CH3O2→CH3+CH3O2H, H+O2→O+OH, etc.) are not substantially affected by CO2 dilution, neither are the species that are pointed by CSP (CH3O2, H2O2, CH2O, etc.) as having the largest impact on the this timescale. The same holds for the modes that control CO and NO formation. The results point to the possibility of cold exhaust gas recirculation being used in order to produce mixtures with longer ignition delays and therefore substantial resistance to uncontrolled ignition.

Beta-decay rate and beta-delayed neutron emission probability of improved gross theory

Science.gov (United States)

Koura, Hiroyuki

2014-09-01

A theoretical study has been carried out on beta-decay rate and beta-delayed neutron emission probability. The gross theory of the beta decay is based on an idea of the sum rule of the beta-decay strength function, and has succeeded in describing beta-decay half-lives of nuclei overall nuclear mass region. The gross theory includes not only the allowed transition as the Fermi and the Gamow-Teller, but also the first-forbidden transition. In this work, some improvements are introduced as the nuclear shell correction on nuclear level densities and the nuclear deformation for nuclear strength functions, those effects were not included in the original gross theory. The shell energy and the nuclear deformation for unmeasured nuclei are adopted from the KTUY nuclear mass formula, which is based on the spherical-basis method. Considering the properties of the integrated Fermi function, we can roughly categorized energy region of excited-state of a daughter nucleus into three regions: a highly-excited energy region, which fully affect a delayed neutron probability, a middle energy region, which is estimated to contribute the decay heat, and a region neighboring the ground-state, which determines the beta-decay rate. Some results will be given in the presentation. A theoretical study has been carried out on beta-decay rate and beta-delayed neutron emission probability. The gross theory of the beta decay is based on an idea of the sum rule of the beta-decay strength function, and has succeeded in describing beta-decay half-lives of nuclei overall nuclear mass region. The gross theory includes not only the allowed transition as the Fermi and the Gamow-Teller, but also the first-forbidden transition. In this work, some improvements are introduced as the nuclear shell correction on nuclear level densities and the nuclear deformation for nuclear strength functions, those effects were not included in the original gross theory. The shell energy and the nuclear deformation for

Dual role of delay effects in a tumour-immune system.

Science.gov (United States)

Yu, Min; Dong, Yueping; Takeuchi, Yasuhiro

2017-08-01

In this paper, a previous tumour-immune interaction model is simplified by neglecting a relatively weak direct immune activation by the tumour cells, which can still keep the essential dynamics properties of the original model. As the immune activation process is not instantaneous, we now incorporate one delay for the activation of the effector cells (ECs) by helper T cells (HTCs) into the model. Furthermore, we investigate the stability and instability regions of the tumour-presence equilibrium state of the delay-induced system with respect to two parameters, the activation rate of ECs by HTCs and the HTCs stimulation rate by the presence of identified tumour antigens. We show the dual role of this delay that can induce stability switches exhibiting destabilization as well as stabilization of the tumour-presence equilibrium. Besides, our results reveal that an appropriate immune activation time delay plays a significant role in control of tumour growth.

Delay-aware adaptive sleep mechanism for green wireless-optical broadband access networks

Science.gov (United States)

Wang, Ruyan; Liang, Alei; Wu, Dapeng; Wu, Dalei

2017-07-01

Wireless-Optical Broadband Access Network (WOBAN) is capacity-high, reliable, flexible, and ubiquitous, as it takes full advantage of the merits from both optical communication and wireless communication technologies. Similar to other access networks, the high energy consumption poses a great challenge for building up WOBANs. To shot this problem, we can make some load-light Optical Network Units (ONUs) sleep to reduce the energy consumption. Such operation, however, causes the increased packet delay. Jointly considering the energy consumption and transmission delay, we propose a delay-aware adaptive sleep mechanism. Specifically, we develop a new analytical method to evaluate the transmission delay and queuing delay over the optical part, instead of adopting M/M/1 queuing model. Meanwhile, we also analyze the access delay and queuing delay of the wireless part. Based on such developed delay models, we mathematically derive ONU's optimal sleep time. In addition, we provide numerous simulation results to show the effectiveness of the proposed mechanism.

Time-dependent delayed signatures from energetic photon interrogations

International Nuclear Information System (INIS)

Norman, Daren R.; Jones, James L.; Blackburn, Brandon W.; Haskell, Kevin J.; Johnson, James T.; Watson, Scott M.; Hunt, Alan W.; Spaulding, Randy; Harmon, Frank

2007-01-01

Pulsed photonuclear interrogation environments generated by 8-24 MeV electron linac are rich with time-dependent, material-specific, radiation signatures. Nitrogen-based explosives and nuclear materials can be detected by exploiting these signatures in different delayed-time regions. Numerical and experimental results presented in this paper show the unique time and energy dependence of these signatures. It is shown that appropriate delayed-time windows are essential to acquire material-specific signatures in pulsed photonuclear assessment environments. These developments demonstrate that pulsed, high-energy, photon-inspection environments can be exploited for time-dependent, material-specific signatures through the proper operation of specialized detectors and detection methods

Representing delayed force feedback as a combination of current and delayed states.

Science.gov (United States)

Avraham, Guy; Mawase, Firas; Karniel, Amir; Shmuelof, Lior; Donchin, Opher; Mussa-Ivaldi, Ferdinando A; Nisky, Ilana

2017-10-01

To adapt to deterministic force perturbations that depend on the current state of the hand, internal representations are formed to capture the relationships between forces experienced and motion. However, information from multiple modalities travels at different rates, resulting in intermodal delays that require compensation for these internal representations to develop. To understand how these delays are represented by the brain, we presented participants with delayed velocity-dependent force fields, i.e., forces that depend on hand velocity either 70 or 100 ms beforehand. We probed the internal representation of these delayed forces by examining the forces the participants applied to cope with the perturbations. The findings showed that for both delayed forces, the best model of internal representation consisted of a delayed velocity and current position and velocity. We show that participants relied initially on the current state, but with adaptation, the contribution of the delayed representation to adaptation increased. After adaptation, when the participants were asked to make movements with a higher velocity for which they had not previously experienced with the delayed force field, they applied forces that were consistent with current position and velocity as well as delayed velocity representations. This suggests that the sensorimotor system represents delayed force feedback using current and delayed state information and that it uses this representation when generalizing to faster movements. NEW & NOTEWORTHY The brain compensates for forces in the body and the environment to control movements, but it is unclear how it does so given the inherent delays in information transmission and processing. We examined how participants cope with delayed forces that depend on their arm velocity 70 or 100 ms beforehand. After adaptation, participants applied opposing forces that revealed a partially correct representation of the perturbation using the current and the

The influence of parametric and external noise in act-and-wait control with delayed feedback.

Science.gov (United States)

Wang, Jiaxing; Kuske, Rachel

2017-11-01

We apply several novel semi-analytic approaches for characterizing and calculating the effects of noise in a system with act-and-wait control. For concrete illustration, we apply these to a canonical balance model for an inverted pendulum to study the combined effect of delay and noise within the act-and-wait setting. While the act-and-wait control facilitates strong stabilization through deadbeat control, a comparison of different models with continuous vs. discrete updating of the control strategy in the active period illustrates how delays combined with the imprecise application of the control can seriously degrade the performance. We give several novel analyses of a generalized act-and-wait control strategy, allowing flexibility in the updating of the control strategy, in order to understand the sensitivities to delays and random fluctuations. In both the deterministic and stochastic settings, we give analytical and semi-analytical results that characterize and quantify the dynamics of the system. These results include the size and shape of stability regions, densities for the critical eigenvalues that capture the rate of reaching the desired stable equilibrium, and amplification factors for sustained fluctuations in the context of external noise. They also provide the dependence of these quantities on the length of the delay and the active period. In particular, we see that the combined influence of delay, parametric error, or external noise and on-off control can qualitatively change the dynamics, thus reducing the robustness of the control strategy. We also capture the dependence on how frequently the control is updated, allowing an interpolation between continuous and frequent updating. In addition to providing insights for these specific models, the methods we propose are generalizable to other settings with noise, delay, and on-off control, where analytical techniques are otherwise severely scarce.

Study of the dynamics of an equation with two large different-order delays

International Nuclear Information System (INIS)

Kashchenko, I.S.

2016-01-01

The case where the larger delay is proportional to the square of the smaller delay is studied in detail. Regions of stability and instability of the equilibrium state and critical cases are found. In all critical cases, special evolutionary equations (quasinormal forms) are constructed. Their non-local dynamics determines the local behavior of solutions of the original equation [ru

Asymptotic Delay Analysis for Cross-Layer Delay-Based Routing in Ad Hoc Networks

Directory of Open Access Journals (Sweden)

Philippe Jacquet

2007-01-01

Full Text Available This paper addresses the problem of the evaluation of the delay distribution via analytical means in IEEE 802.11 wireless ad hoc networks. We show that the asymptotic delay distribution can be expressed as a power law. Based on the latter result, we present a cross-layer delay estimation protocol and we derive new delay-distribution-based routing algorithms, which are well adapted to the QoS requirements of real-time multimedia applications. In fact, multimedia services are not sensitive to average delays, but rather to the asymptotic delay distributions. Indeed, video streaming applications drop frames when they are received beyond a delay threshold, determined by the buffer size. Although delay-distribution-based routing is an NP-hard problem, we show that it can be solved in polynomial time when the delay threshold is large, because of the asymptotic power law distribution of the link delays.

Stability region for a prompt power variation of a coupled-core system with positive prompt feedback

International Nuclear Information System (INIS)

Watanabe, S.; Nishina, K.

1984-01-01

A stability analysis using a one-group model is presented for a coupled-core system. Positive prompt feedback of a γp /SUB j/ form is assumed, where p /SUB j/ is the fractional power variation of core j. Prompt power variations over a range of a few milliseconds after a disturbance are analyzed. The analysis combines Lapunov's method, prompt jump approximation, and the eigenfunction expansion of coupling region response flux. The last is treated as a pseudo-delayed neutron precursor. An asymptotic stability region is found for p /SUB j/. For an asymmetric flux variation over a system of two coupled cores, either p /SUB I/ or p /SUB II/ can slightly exceed, by virtue of the coupling effect, the critical value (β/γ-1) of a single-core case. Such a stability region is increased by additional inclusion of the coupling region fundamental mode in the treatment. The coupling region contributes to stability through its delayed response and coupling. An optimum core separation distance for stability is found

Data Mining for Understanding and Improving Decision-making Affecting Ground Delay Programs

Science.gov (United States)

Kulkarni, Deepak; Wang, Yao; Sridhar, Banavar

2013-01-01

The continuous growth in the demand for air transportation results in an imbalance between airspace capacity and traffic demand. The airspace capacity of a region depends on the ability of the system to maintain safe separation between aircraft in the region. In addition to growing demand, the airspace capacity is severely limited by convective weather. During such conditions, traffic managers at the FAA's Air Traffic Control System Command Center (ATCSCC) and dispatchers at various Airlines' Operations Center (AOC) collaborate to mitigate the demand-capacity imbalance caused by weather. The end result is the implementation of a set of Traffic Flow Management (TFM) initiatives such as ground delay programs, reroute advisories, flow metering, and ground stops. Data Mining is the automated process of analyzing large sets of data and then extracting patterns in the data. Data mining tools are capable of predicting behaviors and future trends, allowing an organization to benefit from past experience in making knowledge-driven decisions.

Micromachined silicon acoustic delay line with improved structural stability and acoustic directivity for real-time photoacoustic tomography

Science.gov (United States)

Cho, Young; Kumar, Akhil; Xu, Song; Zou, Jun

2017-03-01

Recent studies have shown that micromachined silicon acoustic delay lines can provide a promising solution to achieve real-time photoacoustic tomography without the need for complex transducer arrays and data acquisition electronics. However, as its length increases to provide longer delay time, the delay line becomes more vulnerable to structural instability due to reduced mechanical stiffness. In addition, the small cross-section area of the delay line results in a large acoustic acceptance angle and therefore poor directivity. To address these two issues, this paper reports the design, fabrication, and testing of a new silicon acoustic delay line enhanced with 3D printed polymer micro linker structures. First, mechanical deformation of the silicon acoustic delay line (with and without linker structures) under gravity was simulated by using finite element method. Second, the acoustic crosstalk and acoustic attenuation caused by the polymer micro linker structures were evaluated with both numerical simulation and ultrasound transmission testing. The result shows that the use of the polymer micro linker structures significantly improves the structural stability of the silicon acoustic delay lines without creating additional acoustic attenuation and crosstalk. In addition, a new tapered design for the input terminal of the delay line was also investigate to improve its acoustic directivity by reducing the acoustic acceptance angle. These two improvements are expected to provide an effective solution to eliminate current limitations on the achievable acoustic delay time and out-of-plane imaging resolution of micromachined silicon acoustic delay line arrays.

Cross-cultural comparisons of delay discounting of gain and loss.

Science.gov (United States)

Ishii, Keiko; Gang, Lili; Takahashi, Taiki

2016-11-01

People generally tend to discount future outcomes in favor of smaller but immediate gains (i.e., delay discounting). The present research examined cultural similarities and differences in delay discounting of gain and loss between Chinese and Japanese, based on a q-exponential model of intertemporal choice. Using a hypothetical situation, we asked 65 Japanese participants and 51 Chinese participants to choose between receiving (or paying) a different amount of money immediately or with a specified delay (1 week, 2 weeks, 1 month, 6 months, 1 year, 5 years, and 25 years). For each delay, participants completed a series of 40 binary choices for gain or loss. Regardless of cultures, the q-exponential model was the optimal model. Both impulsivity and time-inconsistency were higher for future gains than for future losses. In addition to the cultural similarities, Chinese participants discounted future gains and losses more steeply than did Japanese. In contrast, Japanese participants were more time-inconsistent in delay discounting than were Chinese, suggesting that the reduction in their subjective value depended relatively on delay.

Global synchronization of a class of delayed complex networks

International Nuclear Information System (INIS)

Li Ping; Yi Zhang; Zhang Lei

2006-01-01

Global synchronization of a class of complex networks with time-varying delays is investigated in this paper. Some sufficient conditions are derived. These conditions show that the synchronization of delayed complex networks can be determined by their topologies. In addition, these conditions are simply represented in terms of the networks coupling matrix and are easy to be checked. A typical example of complex networks with chaotic nodes is employed to illustrate the obtained global synchronization results

Delayed fission

Energy Technology Data Exchange (ETDEWEB)

Hatsukawa, Yuichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

1997-07-01

Delayed fission is a nuclear decay process that couples {beta} decay and fission. In the delayed fission process, a parent nucleus undergoes {beta} decay and thereby populates excited states in the daughter. If these states are of energies comparable to or greater than the fission barrier of the daughter, then fission may compete with other decay modes of the excited states in the daughter. In this paper, mechanism and some experiments of the delayed fission will be discussed. (author)

Factors Associated with Delayed Enrollment in HIV Medical Care among HIV-Positive Individuals in Odessa Region, Ukraine.

Science.gov (United States)

Neduzhko, Oleksandr; Postnov, Oleksandr; Perehinets, Ihor; DeHovitz, Jack; Joseph, Michael; Odegaard, David; Kaplan, Robert; Kiriazova, Tetiana

In Ukraine, about one-third of identified HIV-positive individuals are not connected to care. We conducted a cross-sectional survey (n = 200) among patients registered at Odessa AIDS centers in October to December 2011. Factors associated with delayed enrollment in HIV care (>3 months since positive HIV test) were evaluated using logistic regression. Among study participants (mean age 35 ± 8.2 years, 47.5% female, 42.5% reported history of injecting drugs), 55% delayed HIV care enrollment. Odds of delayed enrollment were higher for those with lower educational attainment (adjusted odds ratio [aOR]: 2.65, 95% confidence interval [CI]: 1.04-6.76), not feeling ill (aOR: 2.98, 95% CI: 1.50-5.93), or not having time to go to the AIDS center (aOR: 3.89, 95% CI: 1.39-10.89); injection drug use was not associated with delayed enrollment. Programs linking HIV-positive individuals to specialized care should address enrollment barriers and include education on HIV care benefits and case management for direct linkage to care. HIV testing and treatment should be coupled to ensure a continuum of care.

Factors associated with patient and provider delays for tuberculosis diagnosis and treatment in Asia: a systematic review and meta-analysis.

Directory of Open Access Journals (Sweden)

Jing Cai

Full Text Available Delays in tuberculosis (TB diagnosis and treatment is a major barrier to effective management of the disease. Determining the factors associated with patient and provider delay of TB diagnosis and treatment in Asia may contribute to TB prevention and control.We searched the PubMed, EMBASE and Web of Science for studies that assessed factors associated with delays in care-seeking, diagnosis, or at the beginning of treatment, which were published from January 1992 to September 2014. Two reviewers independently identified studies that were related to our meta-analysis and extracted data from each study. Independent variables were categorized in separate tables for patient and provider delays.Among 45 eligible studies, 40 studies assessed patient delay whereas 30 assessed provider delay. Cross-sectional surveys were used in all but two articles, which included 17 countries and regions. Socio-demographic characteristics, TB-related symptoms and medical examination, and conditions of seeking medical care in TB patients were frequently reported. Male patients and long travel time/distance to the first healthcare provider led to both shorter patient delays [odds ratio (OR (95% confidence intervals, CI = 0.85 (0.78, 0.92; 1.39 (1.08, 1.78] and shorter provider delays [OR (95%CI = 0.96 (0.93, 1.00; 1.68 (1.12, 2.51]. Unemployment, low income, hemoptysis, and positive sputum smears were consistently associated with patient delay [ORs (95%CI = 1.18 (1.07, 1.30, 1.23 (1.02, 1.49, 0.64 (0.40, 1.00, 1.77 (1.07, 2.94, respectively]. Additionally, consultation at a public hospital was associated with provider delay [OR (95%CI = 0.43 (0.20, 0.91].We propose that the major opportunities to reduce delays involve enabling socio-demographic factors and medical conditions. Male, unemployed, rural residence, low income, hemoptysis, positive sputum smear, and long travel time/distance significantly correlated with patient delay. Male, long travel time/distance and

D-leaping: Accelerating stochastic simulation algorithms for reactions with delays

International Nuclear Information System (INIS)

Bayati, Basil; Chatelain, Philippe; Koumoutsakos, Petros

2009-01-01

We propose a novel, accelerated algorithm for the approximate stochastic simulation of biochemical systems with delays. The present work extends existing accelerated algorithms by distributing, in a time adaptive fashion, the delayed reactions so as to minimize the computational effort while preserving their accuracy. The accuracy of the present algorithm is assessed by comparing its results to those of the corresponding delay differential equations for a representative biochemical system. In addition, the fluctuations produced from the present algorithm are comparable to those from an exact stochastic simulation with delays. The algorithm is used to simulate biochemical systems that model oscillatory gene expression. The results indicate that the present algorithm is competitive with existing works for several benchmark problems while it is orders of magnitude faster for certain systems of biochemical reactions.

Energy management - The delayed flap approach

Science.gov (United States)

Bull, J. S.

1976-01-01

Flight test evaluation of a Delayed Flap approach procedure intended to provide reductions in noise and fuel consumption is underway using the NASA CV-990 test aircraft. Approach is initiated at a high airspeed (240 kt) and in a drag configuration that allows for low thrust. The aircraft is flown along the conventional ILS glide slope. A Fast/Slow message display signals the pilot when to extend approach flaps, landing gear, and land flaps. Implementation of the procedure in commercial service may require the addition of a DME navigation aid co-located with the ILS glide slope transmitter. The Delayed Flap approach saves 250 lb of fuel over the Reduced Flap approach, with a 95 EPNdB noise contour only 43% as large.

Interaction of lithium ferrite with low-melting additives in the region of their low concentrations

International Nuclear Information System (INIS)

Mozhaev, A.P.; Olejnikov, N.N.; Shumilkin, N.S.; Fadeeva, V.I.

1977-01-01

The state diagrams of the Lisub(0.5)Fesub(2.5)O 4 - V 2 O 5 system has been studied in the region of small concentrations of V 2 O 5 (up to 3 wt.%). The existance regions of V 2 O 5 solid solutions in lithium ferrite have been determined. The possibility of using the state diagram for choosing optimum conditions of sintering has been shown. Addition of V 2 O 5 (up to 3 wt.%) intensifies the process of magnetic ceramics sintering

Dynamics in a delayed-neural network

International Nuclear Information System (INIS)

Yuan Yuan

2007-01-01

In this paper, we consider a neural network of four identical neurons with time-delayed connections. Some parameter regions are given for global, local stability and synchronization using the theory of functional differential equations. The root distributions in the corresponding characteristic transcendental equation are analyzed, Pitchfork bifurcation, Hopf and equivariant Hopf bifurcations are investigated by revealing the center manifolds and normal forms. Numerical simulations are shown the agreements with the theoretical results

Fuzzy delay model based fault simulator for crosstalk delay fault test ...

Indian Academy of Sciences (India)

In this paper, a fuzzy delay model based crosstalk delay fault simulator is proposed. As design .... To find the quality of non-robust tests, a fuzzy delay ..... Dubois D and Prade H 1989 Processing Fuzzy temporal knowledge. IEEE Transactions ...

Delayed power analysis

International Nuclear Information System (INIS)

Adamovich, L.A.; Azarov, V.V.

1999-01-01

Time dependent core power behavior in a nuclear reactor is described with well-known neutron kinetics equations. At the same time, two portions are distinguished in energy released from uranium nuclei fission; one released directly at fission and another delayed (residual) portion produced during radioactive decay of fission products. While prompt power is definitely described with kinetics equations, the delayed power presentation still remains outstanding. Since in operation the delayed power part is relatively small (about 6%) operation, it can be neglected for small reactivity disturbances assuming that entire power obeys neutron kinetics equations. In case of a high negative reactivity rapidly inserted in core (e.g. reactor scram initiation) the prompt and delayed components can be calculated separately with practically no impact on each other, employing kinetics equations for prompt power and known approximation formulas for delayed portion, named residual in this specific case. Under substantial disturbances the prompt component in the dynamic process becomes commensurable with delayed portion, thus making necessary to take into account their cross impact. A system of differential equations to describe time-dependent behavior of delayed power is presented. Specific NPP analysis shows a way to significantly simplify the task formulation. (author)

Regional P-wave Tomography in the Caribbean Region for Plate Reconstruction

Science.gov (United States)

Li, X.; Bedle, H.; Suppe, J.

2017-12-01

The complex plate-tectonic interactions around the Caribbean Sea have been studied and interpreted by many researchers, but questions still remain regarding the formation and subduction history of the region. Here we report current progress towards creating a new regional tomographic model, with better lateral and spatial coverage and higher resolution than has been presented previously. This new model will provide improved constraints on the plate-tectonic evolution around the Caribbean Plate. Our three-dimensional velocity model is created using taut spline parameterization. The inversion is computed by the code of VanDecar (1991), which is based on the ray theory method. The seismic data used in this inversion are absolute P wave arrival times from over 700 global earthquakes that were recorded by over 400 near Caribbean stations. There are over 25000 arrival times that were picked and quality checked within frequency band of 0.01 - 0.6 Hz by using a MATLAB GUI-based software named Crazyseismic. The picked seismic delay time data are analyzed and compared with other studies ahead of doing the inversion model, in order to examine the quality of our dataset. From our initial observations of the delay time data, the more equalized the ray azimuth coverage, the smaller the deviation of the observed travel times from the theoretical travel time. Networks around the NE and SE side of the Caribbean Sea generally have better ray coverage, and smaller delay times. Specifically, seismic rays reaching SE Caribbean networks, such as XT network, generally pass through slabs under South American, Central American, Lesser Antilles, Southwest Caribbean, and the North Caribbean transform boundary, which leads to slightly positive average delay times. In contrast, the Puerto Rico network records seismic rays passing through regions that may lack slabs in the upper mantle and show slightly negative or near zero average delay times. These results agree with previous tomographic

Steady State Analysis of Stochastic Systems with Multiple Time Delays

Science.gov (United States)

Xu, W.; Sun, C. Y.; Zhang, H. Q.

In this paper, attention is focused on the steady state analysis of a class of nonlinear dynamic systems with multi-delayed feedbacks driven by multiplicative correlated Gaussian white noises. The Fokker-Planck equations for delayed variables are at first derived by Novikov's theorem. Then, under small delay assumption, the approximate stationary solutions are obtained by the probability density approach. As a special case, the effects of multidelay feedbacks and the correlated additive and multiplicative Gaussian white noises on the response of a bistable system are considered. It is shown that the obtained analytical results are in good agreement with experimental results in Monte Carlo simulations.

Performance investigation of stochastic resonance in bistable systems with time-delayed feedback and three types of asymmetries

Science.gov (United States)

Liu, Jian; Wang, Youguo

2018-03-01

The simultaneous influence of potential asymmetries and time-delayed feedback on stochastic resonance (SR) subject to both periodic force and additive Gaussian white noise is investigated by using two-state theory and small-delay approximation, where three types of asymmetries include well-depth, well-width, and both well-depth and well-width asymmetries, respectively. The asymmetric types and time-delayed feedback determine the behaviors of SR, especially output signal-to-noise ratio (SNR) peaks, optimal additive noise intensity and feedback intensity. Moreover, the largest SNR in asymmetric SR is found to be relatively larger than symmetric one in some cases, whereas in other cases the symmetric SR is superior to asymmetric one, which is of dependence on time delay and feedback intensity. In addition, the SR with well-width asymmetry can suppress stronger noise than that with well-depth asymmetry under the action of same time delay, which is beneficial to weak signal detection.

Effects of intrinsic stochasticity on delayed reaction-diffusion patterning systems

KAUST Repository

Woolley, Thomas E.; Baker, Ruth E.; Gaffney, Eamonn A.; Maini, Philip K.; Seirin-Lee, Sungrim

2012-01-01

Cellular gene expression is a complex process involving many steps, including the transcription of DNA and translation of mRNA; hence the synthesis of proteins requires a considerable amount of time, from ten minutes to several hours. Since diffusion-driven instability has been observed to be sensitive to perturbations in kinetic delays, the application of Turing patterning mechanisms to the problem of producing spatially heterogeneous differential gene expression has been questioned. In deterministic systems a small delay in the reactions can cause a large increase in the time it takes a system to pattern. Recently, it has been observed that in undelayed systems intrinsic stochasticity can cause pattern initiation to occur earlier than in the analogous deterministic simulations. Here we are interested in adding both stochasticity and delays to Turing systems in order to assess whether stochasticity can reduce the patterning time scale in delayed Turing systems. As analytical insights to this problem are difficult to attain and often limited in their use, we focus on stochastically simulating delayed systems. We consider four different Turing systems and two different forms of delay. Our results are mixed and lead to the conclusion that, although the sensitivity to delays in the Turing mechanism is not completely removed by the addition of intrinsic noise, the effects of the delays are clearly ameliorated in certain specific cases. © 2012 American Physical Society.

Effects of intrinsic stochasticity on delayed reaction-diffusion patterning systems

KAUST Repository

Woolley, Thomas E.

2012-05-22

Cellular gene expression is a complex process involving many steps, including the transcription of DNA and translation of mRNA; hence the synthesis of proteins requires a considerable amount of time, from ten minutes to several hours. Since diffusion-driven instability has been observed to be sensitive to perturbations in kinetic delays, the application of Turing patterning mechanisms to the problem of producing spatially heterogeneous differential gene expression has been questioned. In deterministic systems a small delay in the reactions can cause a large increase in the time it takes a system to pattern. Recently, it has been observed that in undelayed systems intrinsic stochasticity can cause pattern initiation to occur earlier than in the analogous deterministic simulations. Here we are interested in adding both stochasticity and delays to Turing systems in order to assess whether stochasticity can reduce the patterning time scale in delayed Turing systems. As analytical insights to this problem are difficult to attain and often limited in their use, we focus on stochastically simulating delayed systems. We consider four different Turing systems and two different forms of delay. Our results are mixed and lead to the conclusion that, although the sensitivity to delays in the Turing mechanism is not completely removed by the addition of intrinsic noise, the effects of the delays are clearly ameliorated in certain specific cases. © 2012 American Physical Society.

Patient Delay, Diagnosis Delay and Treatment Delay for Breast Cancer: Comparison of the Pattern between Patients in Public and Private Health Sectors

Directory of Open Access Journals (Sweden)

Iraj Harirchi

2015-05-01

Full Text Available Background: The purpose of this study was to compare patient delay, diagnosis delay and treatment delay in breast cancer patients of selected public and private health centers in Tehran, Iran.Methods: In this cross-sectional study, female patients with newly diagnosed breast cancer in a public medical complex and a private breast clinic within one year were included. Patient delay was considered positive, if the interval between the detection of the first symptom by the patient and the first visit to a health care provider took longer than one month. Delay in diagnosis was defined as the period of more than one week between the first medical visit for the symptoms and the diagnosis of breast cancer. Following the confirmed diagnosis of breast malignancy, if the medical treatment was initiated later than one week, treatment delay had occurred. The potential reasons for patient, diagnosis and treatment delay according to the patients’ reports were also recorded.Results: Overall, 385 patients were included of whom 52.7% were recruited from the public hospitals and 47.3% from a private clinic. The prevalence of patient delay, diagnosis delay and treatment delay were 31.7%, 17.9% and 28.3%, respectively. Patient delay was significantly more common among patients with lower socio-economic status and those recruited from the public hospitals. All the patients with diagnosis delay were in the group recruited from the public hospitals.Conclusions: Gaps between women of different socio-economic levels of the society need to be addressed in order to decrease patient, diagnosis and treatment delay.

Speech and Language Delay

Science.gov (United States)

... OTC Relief for Diarrhea Home Diseases and Conditions Speech and Language Delay Condition Speech and Language Delay Share Print Table of Contents1. ... Treatment6. Everyday Life7. Questions8. Resources What is a speech and language delay? A speech and language delay ...

The role of cooperation and parasites in non-linear replicator delayed extinctions

International Nuclear Information System (INIS)

Sardanyes, Josep; Sole, Ricard V.

2007-01-01

In the present work we study the role of cooperation and parasites on extinction delayed transitions for self-replicating species with catalytic activity. We first use a one-dimensional continuous equation to study the dynamics of both single autocatalytic replicator and symmetric two-member hypercycles, where two well-defined phases involving survival and extinction of replicators are shown to exist. Extinction dynamics is analyzed numerically and analytically and under both deterministic and stochastic scenarios. A ghost is also found for the single autocatalytic replicator and for the asymmetric hypercycle, with an extinction time delay following the square-root scaling law near bifurcation threshold. We find that the extinction delay is longer for the two-member hypercycle than for the single autocatalytic species, indicating that cooperation among replicators might involve to spend a longer time in the bottle-neck region of the ghost. The asymmetry of the network is shown to prolong the extinction time. We also show that an attached parasite decreases the time spent in the bottle-neck region of the ghost, thus accelerating extinction in these systems of replicators. Nevertheless the effect of the parasite is not so important when replicators catalytically cooperate, being the two-member hypercycle less sensitive to the parasite than the autocatalytic species. Here the hypercycle asymmetry can also significantly increase the delaying capacity. These features make the hypercycle to undergo a longer extinction delay, thus increasing the memory effect of the ghost. We finally explore the role of the ghost in fluctuating media, where the extinction delayed transition is shown to increase the survival probability of cooperating catalytic species

Early and delayed Tc-99m ECD brain SPECT in SLE patients with CNS involvement

International Nuclear Information System (INIS)

Kikukawa, Kaoru; Toyama, Hiroshi; Katayama, Masao

2000-01-01

We compared early and delayed Tc-99m ECD SPECT scans in 32 SLE patients (Group 1, definite neuropsychiatric disorders; Group 2, minor neurologic symptoms or normal) with those of normal controls by visual inspection and semi-quantitative evaluation. With visual interpretation, 13 out of 14 patients in Group 1 (93%) and 7 out of 18 patients in Group 2 (39%) had diffuse uneven decrease in early scans. Seven patients in Group 2 (39%) who had normal early scans demonstrated focal decrease in the medial frontal lobe in delayed scans. With cerebral region to cerebellar ratios, in early scans, the medial frontal lobe in Group 1 and Group 2 was significantly lower than in normal controls, and lateral frontal lobe and occipital lobes in Group 1 were significantly lower than in normal controls. Nevertheless, in delayed scans, every cortical region except for the parietal lode in Groups 1 and 2 was significantly lower than in normal controls. The retention rates in all regions in SLE patients were significantly lower than in normal controls. No case showed SPECT improvement on follow-up studies in either group in spite of clinical improvement. Delayed Tc-99m ECD brain SPECT of high sensitivity might be useful in detecting CNS involvement. Although the SPECT findings did not correlate with the neuropsychiatric symptoms, early and delayed Tc-99m ECD SPECT seems to provide useful objective diagnostic information in SLE patients. (author)

Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

NARCIS (Netherlands)

Gutierrez-Achury, Javier; Zhernakova, Alexandra; Pulit, Sara L.; Trynka, Gosia; Hunt, Karen A.; Romanos, Jihane; Raychaudhuri, Soumya; van Heel, David A.; Wijmenga, Cisca; de Balcker, Paul I. W.

Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and

Delay-enhanced coherence of spiral waves in noisy Hodgkin-Huxley neuronal networks

International Nuclear Information System (INIS)

Wang Qingyun; Perc, Matjaz; Duan Zhisheng; Chen Guanrong

2008-01-01

We study the spatial dynamics of spiral waves in noisy Hodgkin-Huxley neuronal ensembles evoked by different information transmission delays and network topologies. In classical settings of coherence resonance the intensity of noise is fine-tuned so as to optimize the system's response. Here, we keep the noise intensity constant, and instead, vary the length of information transmission delay amongst coupled neurons. We show that there exists an intermediate transmission delay by which the spiral waves are optimally ordered, hence indicating the existence of delay-enhanced coherence of spatial dynamics in the examined system. Additionally, we examine the robustness of this phenomenon as the diffusive interaction topology changes towards the small-world type, and discover that shortcut links amongst distant neurons hinder the emergence of coherent spiral waves irrespective of transmission delay length. Presented results thus provide insights that could facilitate the understanding of information transmission delay on realistic neuronal networks

Imprints of the quasar structure in time-delay light curves: Microlensing-aided reverberation mapping

Science.gov (United States)

Sluse, D.; Tewes, M.

2014-11-01

The advent of large area photometric surveys has raised a great deal of interest in the possibility of using broadband photometric data, instead of spectra, to measure the size of the broad line region of active galactic nuclei. We describe here a new method that uses time-delay lensed quasars where one or several images are affected by microlensing due to stars in the lensing galaxy. Because microlensing decreases (or increases) the flux of the continuum compared to the broad line region, it changes the contrast between these two emission components. We show that this effect can be used to effectively disentangle the intrinsic variability of those two regions, offering the opportunity to perform reverberation mapping based on single-band photometric data. Based on simulated light curves generated using a damped random walk model of quasar variability, we show that measurement of the size of the broad line region can be achieved using this method, provided one spectrum has been obtained independently during the monitoring. This method is complementary to photometric reverberation mapping and could also be extended to multi-band data. Because the effect described above produces a variability pattern in difference light curves between pairs of lensed images that is correlated with the time-lagged continuum variability, it can potentially produce systematic errors in measurement of time delays between pairs of lensed images. Simple simulations indicate that time-delay measurement techniques that use a sufficiently flexible model for the extrinsic variability are not affected by this effect and produce accurate time delays.

Noise transmission and delay-induced stochastic oscillations in biochemical network motifs

International Nuclear Information System (INIS)

Liu Sheng-Jun; Wang Qi; Liu Bo; Yan Shi-Wei; Sakata Fumihiko

2011-01-01

With the aid of stochastic delayed-feedback differential equations, we derive an analytic expression for the power spectra of reacting molecules included in a generic biological network motif that is incorporated with a feedback mechanism and time delays in gene regulation. We systematically analyse the effects of time delays, the feedback mechanism, and biological stochasticity on the power spectra. It has been clarified that the time delays together with the feedback mechanism can induce stochastic oscillations at the molecular level and invalidate the noise addition rule for a modular description of the noise propagator. Delay-induced stochastic resonance can be expected, which is related to the stability loss of the reaction systems and Hopf bifurcation occurring for solutions of the corresponding deterministic reaction equations. Through the analysis of the power spectrum, a new approach is proposed to estimate the oscillation period. (interdisciplinary physics and related areas of science and technology)

Medical and nonmedical factors influencing utilization of delayed pushing in the second stage.

Science.gov (United States)

Frey, Heather A; Tuuli, Methodius G; Cortez, Sarah; Odibo, Anthony O; Roehl, Kimberly A; Shanks, Anthony L; Macones, George A; Cahill, Alison G

2013-08-01

To evaluate factors impacting selection to delayed pushing in the second stage of labor. This case-control study was a secondary analysis of a large retrospective cohort study. Cases included women who delayed pushing for 60 minutes or more in the second stage of labor. Controls began pushing prior to 60 minutes from the time of diagnosis of complete dilation. Demographic, labor, and nonmedical factors were compared among cases and controls. Logistic regression modeling was used to identify factors independently associated with delayed pushing. We identified 471 women who delayed pushing and 4819 controls. Nulliparity, maternal body mass index > 25, high fetal station at complete dilation, regional anesthesia use, and start of second stage during staffing shift change were independent factors associated with increased use of delayed pushing. On the other hand, black race and second-stage management during night shift were associated with lower odds of employing delayed pushing. Delayed pushing was more commonly employed in nulliparous women, but 38.9% of multiparous women also delayed pushing. We identified multiple factors associated with use of delayed pushing. This study helps to define current patterns of second-stage labor management. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

A Robust and Multi-Weighted Approach to Estimating Topographically Correlated Tropospheric Delays in Radar Interferograms

Directory of Open Access Journals (Sweden)

Bangyan Zhu

2016-07-01

Full Text Available Spatial and temporal variations in the vertical stratification of the troposphere introduce significant propagation delays in interferometric synthetic aperture radar (InSAR observations. Observations of small amplitude surface deformations and regional subsidence rates are plagued by tropospheric delays, and strongly correlated with topographic height variations. Phase-based tropospheric correction techniques assuming a linear relationship between interferometric phase and topography have been exploited and developed, with mixed success. Producing robust estimates of tropospheric phase delay however plays a critical role in increasing the accuracy of InSAR measurements. Meanwhile, few phase-based correction methods account for the spatially variable tropospheric delay over lager study regions. Here, we present a robust and multi-weighted approach to estimate the correlation between phase and topography that is relatively insensitive to confounding processes such as regional subsidence over larger regions as well as under varying tropospheric conditions. An expanded form of robust least squares is introduced to estimate the spatially variable correlation between phase and topography by splitting the interferograms into multiple blocks. Within each block, correlation is robustly estimated from the band-filtered phase and topography. Phase-elevation ratios are multiply- weighted and extrapolated to each persistent scatter (PS pixel. We applied the proposed method to Envisat ASAR images over the Southern California area, USA, and found that our method mitigated the atmospheric noise better than the conventional phase-based method. The corrected ground surface deformation agreed better with those measured from GPS.

Denials and Delays of Radioactive Material Shipments

International Nuclear Information System (INIS)

El-Shinawy, R.M.K.

2011-01-01

delays of shipments of radioactive materials forms an important issue today. Radioactive materials need to be transported using all modes of transport for use in different applications such as public health, industry, research and production of nuclear power. The transport of radioactive materials is governed by national and international regulations, which are based on the International Atomic Energy Agency (IAEA) regulations for safe transport of radioactive materials (TS-R-1). These regulations ensure high standards of safety. Recently there were increasing numbers of instances of denials and delays of shipments of radioactive materials even when complying with the regulations. The denials and delays can result in difficulties to patients and others who rely on products sterilized by radiation. Therefore there is an urgent need for a universally accepted approach to solve this problem. In response, the IAEA has formed an International Steering Committee (ISC) on denials and delays of radioactive materials. Also, it designate the National Focal Points (NFP) representative to help the ISC members and the IAEA by informing about denial operations and how they can help. The Steering Committee developed and adopted an action plan which includes the action to be taken. This plan is based on: Awareness, Training, Communication, Lobbying for marketing, Economic and Harmonization among member states. It is important to work within the mandate of the ISC and in the line of action plan on denials and delays. It identified the following network members such as: National Focal Points, Regional Coordinators, National Committee, National Representative for different modes of transport and similar bodies, Carriers, Producers and Suppliers, Different civil societies, NGO's, Ministry of transport and others.

Synchronization of delayed systems in the presence of delay time modulation

International Nuclear Information System (INIS)

Kye, Won-Ho; Choi, Muhan; Kim, Myung-Woon; Lee, Soo-Young; Rim, Sunghwan; Kim, Chil-Min; Park, Young-Jai

2004-01-01

We investigate synchronization in the presence of delay time modulation for application to communication. We have observed that the robust synchronization is established by a common delay signal and its threshold is presented using Lyapunov exponents analysis. The influence of the delay time modulation in chaotic oscillators is also discussed

The relaxation time of processes in a FitzHugh-Nagumo neural system with time delay

International Nuclear Information System (INIS)

Gong Ailing; Zeng Chunhua; Wang Hua

2011-01-01

In this paper, we study the relaxation time (RT) of the steady-state correlation function in a FitzHugh-Nagumo neural system under the presence of multiplicative and additive white noises and time delay. The noise correlation parameter λ can produce a critical behavior in the RT as functions of the multiplicative noise intensity D, the additive noise intensity Q and the time delay τ. That is, the RT decreases as the noise intensities D and Q increase, and increases as the time delay τ increases below the critical value of λ. However, above the critical value, the RT first increases, reaches a maximum, and then decreases as D, Q and τ increase, i.e. a noise intensity D or Q and a time delay τ exist, at which the time scales of the relaxation process are at their largest. In addition, the additive noise intensity Q can also produce a critical behavior in the RT as a function of λ. The noise correlation parameter λ first increases the RT of processes, then decreases it below the critical value of Q. Above the critical value, λ increases it.

Modification of radiation-induced division delay by caffeine analogues and dibutyryl cyclic AMP

Energy Technology Data Exchange (ETDEWEB)

Kimler, B.F.; Leeper, D.B.; Snyder, M.H.; Rowley, R.; Schneiderman, M.H. (Thomas Jefferson Univ., Philadelphia, PA (USA). Hospital)

1982-01-01

The mitotic selection procedure for cell cycle analysis was utilized to investigate the concentration-dependent modification of x-radiation-induced division delay in Chinese hamster ovary (CHO) cells by methyl xanthines (caffeine, theophylline, and theobromine) and by dibutyryl cyclic AMP. The methyl xanthines (concentrations from 0.5 to 1000 ..mu..g/ml) all reduced radiation-induced division delay with the effect being linear between approximately 100 and 1000 ..mu..g/ml. After doses of 100-300 rad, delay was reduced by 75, 94 or 83 per cent at 1000 ..mu..g/ml for each drug, respectively. However, the addition of dibutyryl cyclic AMP had an opposite effect: radiation-induced delay was increased by the concentration range of 0.3 to 300 ..mu..g/ml. These results indicate that in mammalian cells the control of cell cycle progression and the modification of radiation-induced division delay are not simply related to intracellular levels of cyclic AMP. Rather, there appear to be at least two competing mechanisms which are differentially affected by caffeine analogues or by direct addition of dibutyryl cyclic AMP. The direct effect of caffeine and the methyl xanthines on membrane calcium permeability is considered.

Modification of radiation-induced division delay by caffeine analogues and dibutyryl cyclic AMP

International Nuclear Information System (INIS)

Kimler, B.F.; Leeper, D.B.; Snyder, M.H.; Rowley, R.; SChneiderman, M.H.

1982-01-01

The mitotic selection procedure for cell cycle analysis was utilized to investigate the concentration-dependent modification of x-radiation-induced division delay in Chinese hamster ovary (CHO) cells by methyl xanthines (caffeine, theophylline, and theobromine) and by dibutyryl cyclic AMP. The methyl xanthines (concentrations from 0.5 to 1000 μg/ml) all reduced radiation-induced division delay with the effect being linear between approximately 100 and 1000 μg/ml. After doses of 100-300 rad, delay was reduced by 75, 94 or 83 per cent at 1000 μg/ml for each drug, respectively. However, the addition of dibutyryl cyclic AMP had an opposite effect: radiation-induced delay was increased by the concentration range of 0.3 to 300 μg/ml. These results indicate that in mammalian cells the control of cell cycle progression and the modification of radiation-induced division delay are not simply related to intracellular levels of cyclic AMP. Rather, there appear to be at least two competing mechanisms which are differentially affected by caffeine analogues or by direct addition of dibutyryl cyclic AMP. The direct effect of caffeine and the methyl xanthines on membrane calcium permeability is considered. (author)

Effect of processing time delay on the dose response of Kodak EDR2 film.

Science.gov (United States)

Childress, Nathan L; Rosen, Isaac I

2004-08-01

Kodak EDR2 film is a widely used two-dimensional dosimeter for intensity modulated radiotherapy (IMRT) measurements. Our clinical use of EDR2 film for IMRT verifications revealed variations and uncertainties in dose response that were larger than expected, given that we perform film calibrations for every experimental measurement. We found that the length of time between film exposure and processing can affect the absolute dose response of EDR2 film by as much as 4%-6%. EDR2 films were exposed to 300 cGy using 6 and 18 MV 10 x 10 cm2 fields and then processed after time delays ranging from 2 min to 24 h. An ion chamber measured the relative dose for these film exposures. The ratio of optical density (OD) to dose stabilized after 3 h. Compared to its stable value, the film response was 4%-6% lower at 2 min and 1% lower at 1 h. The results of the 4 min and 1 h processing time delays were verified with a total of four different EDR2 film batches. The OD/dose response for XV2 films was consistent for time periods of 4 min and 1 h between exposure and processing. To investigate possible interactions of the processing time delay effect with dose, single EDR2 films were irradiated to eight different dose levels between 45 and 330 cGy using smaller 3 x 3 cm2 areas. These films were processed after time delays of 1, 3, and 6 h, using 6 and 18 MV photon qualities. The results at all dose levels were consistent, indicating that there is no change in the processing time delay effect for different doses. The difference in the time delay effect between the 6 and 18 MV measurements was negligible for all experiments. To rule out bias in selecting film regions for OD measurement, we compared the use of a specialized algorithm that systematically determines regions of interest inside the 10 x 10 cm2 exposure areas to manually selected regions of interest. There was a maximum difference of only 0.07% between the manually and automatically selected regions, indicating that the use of

Medical and Non-Medical Factors Influencing Utilization of Delayed Pushing in the Second Stage

Science.gov (United States)

FREY, Heather A.; TUULI, Methodius G.; CORTEZ, Sarah; ODIBO, Anthony O.; ROEHL, Kimberly A.; SHANKS, Anthony L.; MACONES, George A.; CAHILL, Alison G.

2014-01-01

Objective To evaluate factors impacting selection to delayed pushing in the second stage of labor. Study design This case-control study was a secondary analysis of a large retrospective cohort study. Cases included women who delayed pushing for 60 minutes or more in the second stage of labor. Controls began pushing prior to 60 minutes from the time of diagnosis of complete dilation. Demographic, labor, and nonmedical factors were compared among cases and controls. Logistic regression modelling was used to identify factors independently associated with delayed pushing. Results We identified 471 women who delayed pushing and 4,819 controls. Nulliparity, maternal body mass index > 25, high fetal station at complete dilation, regional anesthesia use, and start of second stage during staffing shift change were independent factors associated with increased use of delayed pushing. On the other hand, black race and second stage management during night shift were associated with lower odds of employing delayed pushing. Delayed pushing was more commonly employed in nulliparous women, but 38.9% of multiparous women also delayed pushing. Conclusion We identified multiple factors associated with use of delayed pushing. This study helps to define current patterns of second stage labor management. PMID:23208765

Recent results from SHIP on shape coexistence and electron capture delayed fission in the Pb-Rn region

Energy Technology Data Exchange (ETDEWEB)

Andreyev, Andrei [Insituut voor Kern- en Stralingfysica, Univesity of Leuven (Belgium)

2008-07-01

The contribution reviews the results of our recent experiments at SHIP (GSI, Darmstadt) aimed at the study of very neutron-deficient Pb-Rn nuclides in the vicinity of N=104. The first part presents the unambiguous identification of the EC-delayed fission (ECDF) in the odd-odd isotopes {sup 192,194}At. The ECDF data allow us to study the fission properties of the nuclei which do not decay via spontaneous fission at all. The preliminary analysis indicate unusually high ECDF probabilities for these nuclides. The second part discusses the new data on the shape coexistence in the Pb region. Identification of the new isotopes {sup 193,194}Rn and first experimental evidence for the long-sought ground state deformation in lightest Rn isotopes will be presented. The strong retardation (by a factor of {proportional_to}10) of the half-life of the new isotope {sup 186}Po relative to the classical Geiger-Nuttall rule for alpha decay will be also discussed. This indicates that the Geiger-Nuttall rule is broken in the lightest Po isotopes.

Delay oil oxidation during frying process

International Nuclear Information System (INIS)

Atta, N.M.M.; Shams Eldin, N.M.M.

2010-01-01

Blend oil (mixed of refined sunflower and soy beans oils 1:1 w/w) containing add 200 ppm of rosemary leaves methanolic extract (rosemary extract) (RE) and 3% refined rice bran oil (RRBO), were used in frying process at 1800 degree c for 5 hrs/ day, four consecutive days to delay oil oxidation during frying. Therefore, rosemary extract (methanolic extract) was analyzed by HPLC technique for identification of flavonoids compounds (as a specific active compounds; gives high protection to frying oil). Physical and chemical properties, including refractive index(RI). Red color unit (R), viscosity, acidity (FFA), peroxide value (PV), iodine value (IV) oxidized fatty acid (OFA), polymer content (PC), total polar components (TPC) and trans fatty acid (TFA) as eliadic acid were determined. The results indicated that; rosemary extract contained about eight flavonoids compounds (hypersoid, rutin, 3-OH flavon, luleotin, kempferol, sakarutin, querectrin and apeginin). Addition of RE or RRBO to frying oil caused delay oil oxidation during frying process compared with frying oil without any addition. Also, the results indicated that rosemary extract was more effective in reducing formation of PV, FFA, OFA, PC, TPC and TFA in frying oil than refined rice bran oil

Chaos synchronization in time-delayed systems with parameter mismatches and variable delay times

International Nuclear Information System (INIS)

Shahverdiev, E.M.; Nuriev, R.A.; Hashimov, R.H.; Shore, K.A.

2004-06-01

We investigate synchronization between two undirectionally linearly coupled chaotic nonidentical time-delayed systems and show that parameter mismatches are of crucial importance to achieve synchronization. We establish that independent of the relation between the delay time in the coupled systems and the coupling delay time, only retarded synchronization with the coupling delay time is obtained. We show that with parameter mismatch or without it neither complete nor anticipating synchronization occurs. We derive existence and stability conditions for the retarded synchronization manifold. We demonstrate our approach using examples of the Ikeda and Mackey Glass models. Also for the first time we investigate chaos synchronization in time-delayed systems with variable delay time and find both existence and sufficient stability conditions for the retarded synchronization manifold with the coupling-delay lag time. (author)

Nonlinear Estimation of Discrete-Time Signals Under Random Observation Delay

International Nuclear Information System (INIS)

Caballero-Aguila, R.; Jimenez-Lopez, J. D.; Hermoso-Carazo, A.; Linares-Perez, J.; Nakamori, S.

2008-01-01

This paper presents an approximation to the nonlinear least-squares estimation problem of discrete-time stochastic signals using nonlinear observations with additive white noise which can be randomly delayed by one sampling time. The observation delay is modelled by a sequence of independent Bernoulli random variables whose values, zero or one, indicate that the real observation arrives on time or it is delayed and, hence, the available measurement to estimate the signal is not up-to-date. Assuming that the state-space model generating the signal is unknown and only the covariance functions of the processes involved in the observation equation are ready for use, a filtering algorithm based on linear approximations of the real observations is proposed.

Analysis on Passivity for Uncertain Neural Networks with Time-Varying Delays

Directory of Open Access Journals (Sweden)

O. M. Kwon

2014-01-01

Full Text Available The problem of passivity analysis for neural networks with time-varying delays and parameter uncertainties is considered. By the consideration of newly constructed Lyapunov-Krasovskii functionals, improved sufficient conditions to guarantee the passivity of the concerned networks are proposed with the framework of linear matrix inequalities (LMIs, which can be solved easily by various efficient convex optimization algorithms. The enhancement of the feasible region of the proposed criteria is shown via two numerical examples by the comparison of maximum allowable delay bounds.

Fast realization of nonrecursive digital filters with limits on signal delay

Science.gov (United States)

Titov, M. A.; Bondarenko, N. N.

1983-07-01

Attention is given to the problem of achieving a fast realization of nonrecursive digital filters with the aim of reducing signal delay. It is shown that a realization wherein the impulse characteristic of the filter is divided into blocks satisfies the delay requirements and is almost as economical in terms of the number of multiplications as conventional fast convolution. In addition, the block method leads to a reduction in the needed size of the memory and in the number of additions; the short-convolution procedure is substantially simplified. Finally, the block method facilitates the paralleling of computations owing to the simple transfers between subfilters.

Property Analysis of the Real-Time Uncalibrated Phase Delay Product Generated by Regional Reference Stations and Its Influence on Precise Point Positioning Ambiguity Resolution

Directory of Open Access Journals (Sweden)

Yong Zhang

2017-05-01

Full Text Available The real-time estimation of the wide-lane and narrow-lane Uncalibrated Phase Delay (UPD of satellites is realized by real-time data received from regional reference station networks; The properties of the real-time UPD product and its influence on real-time precise point positioning ambiguity resolution (RTPPP-AR are experimentally analyzed according to real-time data obtained from the regional Continuously Operating Reference Stations (CORS network located in Tianjin, Shanghai, Hong Kong, etc. The results show that the real-time wide-lane and narrow-lane UPD products differ significantly from each other in time-domain characteristics; the wide-lane UPDs have daily stability, with a change rate of less than 0.1 cycle/day, while the narrow-lane UPDs have short-term stability, with significant change in one day. The UPD products generated by different regional networks have obvious spatial characteristics, thus significantly influencing RTPPP-AR: the adoption of real-time UPD products employing the sparse stations in the regional network for estimation is favorable for improving the regional RTPPP-AR up to 99%; the real-time UPD products of different regional networks slightly influence PPP-AR positioning accuracy. After ambiguities are successfully fixed, the real-time dynamic RTPPP-AR positioning accuracy is better than 3 cm in the plane and 8 cm in the upward direction.

Time delays across saddles as a test of modified gravity

International Nuclear Information System (INIS)

Magueijo, João; Mozaffari, Ali

2013-01-01

Modified gravity theories can produce strong signals in the vicinity of the saddles of the total gravitational potential. In a sub-class of these models, this translates into diverging time delays for echoes crossing the saddles. Such models arise from the possibility that gravity might be infrared divergent or confined, and if suitably designed they are very difficult to rule out. We show that Lunar Laser Ranging during an eclipse could probe the time-delay effect within metres of the saddle, thereby proving or excluding these models. Very Large Baseline Interferometry, instead, could target delays across the Jupiter–Sun saddle. Such experiments would shed light on the infrared behaviour of gravity and examine the puzzling possibility that there might be well-hidden regions of strong gravity and even singularities inside the solar system. (fast track communication)

Humans Optimize Decision-Making by Delaying Decision Onset

Science.gov (United States)

Teichert, Tobias; Ferrera, Vincent P.; Grinband, Jack

2014-01-01

Why do humans make errors on seemingly trivial perceptual decisions? It has been shown that such errors occur in part because the decision process (evidence accumulation) is initiated before selective attention has isolated the relevant sensory information from salient distractors. Nevertheless, it is typically assumed that subjects increase accuracy by prolonging the decision process rather than delaying decision onset. To date it has not been tested whether humans can strategically delay decision onset to increase response accuracy. To address this question we measured the time course of selective attention in a motion interference task using a novel variant of the response signal paradigm. Based on these measurements we estimated time-dependent drift rate and showed that subjects should in principle be able trade speed for accuracy very effectively by delaying decision onset. Using the time-dependent estimate of drift rate we show that subjects indeed delay decision onset in addition to raising response threshold when asked to stress accuracy over speed in a free reaction version of the same motion-interference task. These findings show that decision onset is a critical aspect of the decision process that can be adjusted to effectively improve decision accuracy. PMID:24599295

Atmospheric Phase Delay in Sentinel SAR Interferometry

Science.gov (United States)

Krishnakumar, V.; Monserrat, O.; Crosetto, M.; Crippa, B.

2018-04-01

The repeat-pass Synthetic Aperture Radio Detection and Ranging (RADAR) Interferometry (InSAR) has been a widely used geodetic technique for observing the Earth's surface, especially for mapping the Earth's topography and deformations. However, InSAR measurements are prone to atmospheric errors. RADAR waves traverse the Earth's atmosphere twice and experience a delay due to atmospheric refraction. The two major layers of the atmosphere (troposphere and ionosphere) are mainly responsible for this delay in the propagating RADAR wave. Previous studies have shown that water vapour and clouds present in the troposphere and the Total Electron Content (TEC) of the ionosphere are responsible for the additional path delay in the RADAR wave. The tropospheric refractivity is mainly dependent on pressure, temperature and partial pressure of water vapour. The tropospheric refractivity leads to an increase in the observed range. These induced propagation delays affect the quality of phase measurement and introduce errors in the topography and deformation fields. The effect of this delay was studied on a differential interferogram (DInSAR). To calculate the amount of tropospheric delay occurred, the meteorological data collected from the Spanish Agencia Estatal de Meteorología (AEMET) and MODIS were used. The interferograms generated from Sentinel-1 carrying C-band Synthetic Aperture RADAR Single Look Complex (SLC) images acquired on the study area are used. The study area consists of different types of scatterers exhibiting different coherence. The existing Saastamoinen model was used to perform a quantitative evaluation of the phase changes caused by pressure, temperature and humidity of the troposphere during the study. Unless the phase values due to atmospheric disturbances are not corrected, it is difficult to obtain accurate measurements. Thus, the atmospheric error correction is essential for all practical applications of DInSAR to avoid inaccurate height and deformation

ATMOSPHERIC PHASE DELAY IN SENTINEL SAR INTERFEROMETRY

Directory of Open Access Journals (Sweden)

V. Krishnakumar

2018-04-01

Full Text Available The repeat-pass Synthetic Aperture Radio Detection and Ranging (RADAR Interferometry (InSAR has been a widely used geodetic technique for observing the Earth’s surface, especially for mapping the Earth’s topography and deformations. However, InSAR measurements are prone to atmospheric errors. RADAR waves traverse the Earth’s atmosphere twice and experience a delay due to atmospheric refraction. The two major layers of the atmosphere (troposphere and ionosphere are mainly responsible for this delay in the propagating RADAR wave. Previous studies have shown that water vapour and clouds present in the troposphere and the Total Electron Content (TEC of the ionosphere are responsible for the additional path delay in the RADAR wave. The tropospheric refractivity is mainly dependent on pressure, temperature and partial pressure of water vapour. The tropospheric refractivity leads to an increase in the observed range. These induced propagation delays affect the quality of phase measurement and introduce errors in the topography and deformation fields. The effect of this delay was studied on a differential interferogram (DInSAR. To calculate the amount of tropospheric delay occurred, the meteorological data collected from the Spanish Agencia Estatal de Meteorología (AEMET and MODIS were used. The interferograms generated from Sentinel-1 carrying C-band Synthetic Aperture RADAR Single Look Complex (SLC images acquired on the study area are used. The study area consists of different types of scatterers exhibiting different coherence. The existing Saastamoinen model was used to perform a quantitative evaluation of the phase changes caused by pressure, temperature and humidity of the troposphere during the study. Unless the phase values due to atmospheric disturbances are not corrected, it is difficult to obtain accurate measurements. Thus, the atmospheric error correction is essential for all practical applications of DInSAR to avoid inaccurate

Classic conditioning in aged rabbits: delay, trace, and long-delay conditioning.

Science.gov (United States)

Solomon, P R; Groccia-Ellison, M E

1996-06-01

Young (0.5 years) and aged (2+, 3+, and 4+ years) rabbits underwent acquisition of the classically conditioned nictitating membrane response in a delay (500-ms conditioned stimulus [CS], 400-ms interstimulus interval [ISI]), long-delay (1,000-ms CS, 900-ms ISI), or trace (500-ms CS, 400-ms stimulus-free period) paradigm. Collapsing across age groups, there is a general tendency for animals to acquire trace conditioning more slowly than delay conditioning. Collapsing across conditioning paradigms, there is a general tendency for aged animals to acquire more slowly than younger animals. Of greater significance, however, are the age differences in the different conditioning paradigms. In the delay and long-delay paradigms, significant conditioning deficits first appeared in the 4(+)-year-old group. In the trace conditioning paradigm, significant conditioning deficits became apparent in the 2(+)-year-old animals.

The neural basis of cultural differences in delay discounting.

Science.gov (United States)

Kim, Bokyung; Sung, Young Shin; McClure, Samuel M

2012-03-05

People generally prefer to receive rewarding outcomes sooner rather than later. Such preferences result from delay discounting, or the process by which outcomes are devalued for the expected delay until their receipt. We investigated cultural differences in delay discounting by contrasting behaviour and brain activity in separate cohorts of Western (American) and Eastern (Korean) subjects. Consistent with previous reports, we find a dramatic difference in discounting behaviour, with Americans displaying much greater present bias and elevated discount rates. Recent neuroimaging findings suggest that differences in discounting may arise from differential involvement of either brain reward areas or regions in the prefrontal and parietal cortices associated with cognitive control. We find that the ventral striatum is more greatly recruited in Americans relative to Koreans when discounting future rewards, but there is no difference in prefrontal or parietal activity. This suggests that a cultural difference in emotional responsivity underlies the observed behavioural effect. We discuss the implications of this research for strategic interrelations between Easterners and Westerners.

A Fast Time-Delay Calculation Method in Through-Wall-Radar Detection Scenario

Directory of Open Access Journals (Sweden)

Zhang Qi

2016-01-01

Full Text Available In TWR (Through Wall Radar signal processing procedure, time delay estimation is one of the key steps in target localization and high resolution imaging. In time domain imaging procedure such as back projection imaging algorithm, round trip propagation time delay at the path of “transmitter-target-receiver” needs to be calculated for each pixel in imaging region. In typical TWR scenario, transmitter and receiver are at one side and targets at the other side of a wall. Based on two-dimensional searching algorithm or solving two variables equation of four times, traditional time delay calculation algorithms are complex and time consuming, and cannot be used to real-time imaging procedure. In this paper, a new fast time-delay (FTD algorithm is presented. Because of that incident angle at one side equals to refracting angle at the other side, an equation of lateral distance through the wall can be established. By solving this equation, the lateral distance can be obtained and total propagation time delay can be calculated subsequently. Through processing simulation data, the result shows that new algorithm can be applied effectively to real-time time-delay calculation in TWR signal processing.

Delayed neutrons in liquid metal spallation targets

International Nuclear Information System (INIS)

Ridikas, D.; Bokov, P.; David, J.C.; Dore, D.; Giacri, M.L.; Van Lauwe, A.; Plukiene, R.; Plukis, A.; Ignatiev, S.; Pankratov, D.

2003-01-01

The next generation spallation neutron sources, neutrino factories or RIB production facilities currently being designed and constructed around the world will increase the average proton beam power on target by a few orders of magnitude. Increased proton beam power results in target thermal hydraulic issues leading to new target designs, very often based on flowing liquid metal targets such as Hg, Pb, Pb-Bi. Radioactive nuclides produced in liquid metal targets are transported into hot cells, past electronics, into pumps with radiation sensitive components, etc. Besides the considerable amount of photon activity in the irradiated liquid metal, a significant amount of the delayed neutron precursor activity can be accumulated in the target fluid. The transit time from the front of a liquid metal target into areas, where delayed neutrons may be important, can be as short as a few seconds, well within one half-life of many delayed neutron precursors. Therefore, it is necessary to evaluate the total neutron flux (including delayed neutrons) as a function of time and determine if delayed neutrons contribute significantly to the dose rate. In this study the multi-particle transport code MCNPX combined with the material evolution program CINDER'90 will be used to evaluate the delayed neutron flux and spectra. The following scientific issues will be addressed in this paper: - Modeling of a typical geometry of the liquid metal spallation target; - Predictions of the prompt neutron fluxes, fission fragment and spallation product distributions; - Comparison of the above parameters with existing experimental data; - Time-dependent calculations of delayed neutron precursors; - Neutron flux estimates due to the prompt and delayed neutron emission; - Proposal of an experimental program to measure delayed neutron spectra from high energy spallation-fission reactions. The results of this study should be directly applicable in the design study of the European MegaPie (1 MW

Global synchronization criteria with channel time-delay for chaotic time-delay system

International Nuclear Information System (INIS)

Sun Jitao

2004-01-01

Based on the Lyapunov stabilization theory, matrix measure, and linear matrix inequality (LMIs), this paper studies the chaos synchronization of time-delay system using the unidirectional linear error feedback coupling with time-delay. Some generic conditions of chaos synchronization with time-delay in the transmission channel is established. The chaotic Chua's circuit is used for illustration, where the coupling parameters are determined according to the criteria under which the global chaos synchronization of the time-delay coupled systems is achieved

Serotonin Transporter Promoter Region (5-HTTLPR) Polymorphism Is Not Associated With Paroxetine-Induced Ejaculation Delay in Dutch Men With Lifelong Premature Ejaculation

Science.gov (United States)

Janssen, Paddy K.C.; Zwinderman, Aeilko H.; Olivier, Berend

2014-01-01

Purpose To investigate the association between the 5-HT-transporter-gene-linked promoter region (5-HTTLPR) polymorphism and 20-mg paroxetine-induced ejaculation delay in men with lifelong premature ejaculation (LPE). Materials and Methods This was a prospective study of 10 weeks of paroxetine treatment in 54 men with LPE. Intravaginal ejaculation latency time (IELT) was measured by stopwatch. Controls consisted of 92 Caucasian men. All men with LPE were genotyped for the 5-HTTLPR polymorphism. Allele frequencies and genotypes of short (S) and long (L) variants of the polymorphism were compared between patients and controls. Associations between the LL, SL, and SS genotypes and fold increase of mean IELT were investigated. Results Of the 54 patients, 43 (79.6%) responded to 20-mg paroxetine treatment with an ejaculation delay, whereas 11 patients (20.4%) did not respond; 44%, 18%, and 18% of the patients showed a fold increase in mean IELT of 2-10, 10-20, and more than 20, respectively. Of the 54 men, 14 (25.9%) had the LL genotype, 29 (53.7%) had the SL genotype, and 11 (20.4%) had the SS genotype. In the 92 controls, the LL, SL, and SS genotypes were present in 27 (29.3%), 41 (44.6%), and 24 (26.1%), respectively. No statistically significant differences were found in 5-HTTLPR allelic variations or in 5-HTTLPR gene variations. In all men treated with 20 mg paroxetine, analysis of variance of the natural logarithm of fold increase in the IELT showed no statistically significant difference according to genotype (p=0.83). Conclusions The 5-HTTLPR polymorphism is not associated with daily 20-mg paroxetine treatment-induced ejaculation delay in men with LPE. PMID:24578810

Dissociation of verbal working memory system components using a delayed serial recall task.

Science.gov (United States)

Chein, J M; Fiez, J A

2001-11-01

Functional magnetic resonance imaging (fMRI) was used to investigate the neural substrates of component processes in verbal working memory. Based on behavioral research using manipulations of verbal stimulus type to dissociate storage, rehearsal, and executive components of verbal working memory, we designed a delayed serial recall task requiring subjects to encode, maintain, and overtly recall sets of verbal items for which phonological similarity, articulatory length, and lexical status were manipulated. By using a task with temporally extended trials, we were able to exploit the temporal resolution afforded by fMRI to partially isolate neural contributions to encoding, maintenance, and retrieval stages of task performance. Several regions commonly associated with maintenance, including supplementary motor, premotor, and inferior frontal areas, were found to be active across all three trial stages. Additionally, we found that left inferior frontal and supplementary motor regions showed patterns of stimulus and temporal sensitivity implicating them in distinct aspects of articulatory rehearsal, while no regions showed a pattern of sensitivity consistent with a role in phonological storage. Regional modulation by task difficulty was further investigated as a measure of executive processing. We interpret our findings as they relate to notions about the cognitive architecture underlying verbal working memory performance.

Stochastic resonance in a delayed triple-well potential driven by correlated noises.

Science.gov (United States)

Xu, Pengfei; Jin, Yanfei; Xiao, Shaomin

2017-11-01

In this paper, we investigate stochastic resonance (SR) in a delayed triple-well potential subject to correlated noises and a harmonic signal. The stationary probability density, together with the response amplitude of the system, is obtained by using the small time delay approximation. It is found that the time delay, noise intensities, and the cross-correlation between noises can induce the occurrence of the transition. Moreover, the appropriate choice of noise intensities and time delay can improve the output of the system, enhance the SR effect, and lead to the phenomenon of noise enhanced stability. Especially, the stochastic multi-resonance phenomenon is observed when the multiplicative and additive noises are correlated. Finally, the theoretical results are well verified through numerical simulations.

Delayed puberty in girls

Science.gov (United States)

... sexual development - girls; Pubertal delay - girls; Constitutional delayed puberty ... In most cases of delayed puberty, growth changes just begin later than usual, sometimes called a late bloomer. Once puberty begins, it progresses normally. This pattern runs ...

A new method for analyzing diagnostic delay in gynecological cancer

DEFF Research Database (Denmark)

Vandborg, Mai Partridge; Edwards, Kasper; Kragtrup, Jakob

2012-01-01

AND METHODS: Six women with a diagnostic delay of 6 weeks or more before treatment of gynecological cancer at a specialized regional department (the Department of Gynecology and Obstetrics, Odense University Hospital, Denmark) were included in the study. Maps of existing processes were performed for each...

A New Method for Analyzing Diagnostic Delay in Gynecological Cancer

DEFF Research Database (Denmark)

Vandborg, Mai Partridge; Edwards, Kasper; Kragstrup, Jakob

2012-01-01

AND METHODS: Six women with a diagnostic delay of 6 weeks or more before treatment of gynecological cancer at a specialized regional department (the Department of Gynecology and Obstetrics, Odense University Hospital, Denmark) were included in the study. Maps of existing processes were performed for each...

Stabilization of Networked Control Systems with Variable Delays and Saturating Inputs

Directory of Open Access Journals (Sweden)

M. Mahmodi Kaleybar

2014-06-01

Full Text Available In this paper, improved conditions for the synthesis of static state-feedback controller are derived to stabilize networked control systems (NCSs subject to actuator saturation. Both of the data packet latency and dropout which deteriorate the performance of the closed-loop system are considered in the NCS model via variable delays. Two different techniques are employed to incorporate actuator saturation in the system description. Utilizing Lyapunov-Krasovskii Theorem, delay-dependent conditions are obtained in terms of linear matrix inequalities (LMIs to determine the static feedback gain. Moreover, an optimization problem is formulated in order to find the less conservative estimate for the region of attraction corresponding to different maximum allowable delays. Numerical examples are introduced to demonstrate the effectiveness and advantages of the proposed schemes.

Delayed Puberty (For Teens)

Science.gov (United States)

... Safe Videos for Educators Search English Español Delayed Puberty KidsHealth / For Teens / Delayed Puberty What's in this ... wonder if there's anything wrong. What Is Delayed Puberty? Puberty is the time when your body grows ...

Two-actor conflict with time delay: A dynamical model

Science.gov (United States)

Qubbaj, Murad R.; Muneepeerakul, Rachata

2012-11-01

Recent mathematical dynamical models of the conflict between two different actors, be they nations, groups, or individuals, have been developed that are capable of predicting various outcomes depending on the chosen feedback strategies, initial conditions, and the previous states of the actors. In addition to these factors, this paper examines the effect of time delayed feedback on the conflict dynamics. Our analysis shows that under certain initial and feedback conditions, a stable neutral equilibrium of conflict may destabilize for some critical values of time delay, and the two actors may evolve to new emotional states. We investigate the results by constructing critical delay surfaces for different sets of parameters and analyzing results from numerical simulations. These results provide new insights regarding conflict and conflict resolution and may help planners in adjusting and assessing their strategic decisions.

{sup 68}Ga-PSMA I and T PET/CT for assessment of prostate cancer: evaluation of image quality after forced diuresis and delayed imaging

Energy Technology Data Exchange (ETDEWEB)

Derlin, Thorsten; Weiberg, Desiree; Ross, Tobias L.; Bengel, Frank M. [Hannover Medical School, Department of Nuclear Medicine, Hannover (Germany); Klot, Christoph von [Hannover Medical School, Department of Urology and Urologic Oncology, Hannover (Germany); Wester, Hans-Juergen [Technische Universitaet Muenchen, Pharmaceutical Radiochemistry, Garching (Germany); Henkenberens, Christoph; Christiansen, Hans [Hannover Medical School, Department of Radiation Oncology, Hannover (Germany); Merseburger, Axel S. [University Hospital Schleswig-Holstein, Department of Urology, Campus Luebeck, Luebeck (Germany)

2016-12-15

Urinary radiotracer excretion of {sup 68}Ga-Labelled prostate-specific membrane antigen (PSMA) ligands may complicate the assessment of the prostate region and differentiation of lymph nodes from ureteral activity. The aim of this study was to assess the value of delayed imaging after forced diuresis. Sixty-six patients underwent {sup 68}Ga-PSMA I and T PET/CT for evaluation of prostate cancer at 60 min post-injection. In subgroups of patients, this was amended by delayed imaging after 180 min post-injection, preceded by furosemide and oral hydration early, at the time of tracer injection, or delayed, at 100 min post-injection. Urinary tracer activity within the bladder and focal ureteral activity was analyzed. After forced diuresis, linear and focal visualization of ureters was significantly reduced. After delayed furosemide, mean and peak bladder activity decreased (p < 0.001), and image quality of the prostate region improved on delayed images (p < 0.001). Early furosemide co-injection with tracer resulted in increased mean and peak bladder activity (p < 0.001) and in deteriorated image quality of the prostate region on delayed images (p = 0.008). Ga-PSMA I and T PET/CT delayed imaging after forced diuresis can improve the assessment of prostate region and pelvic lymph nodes by removing excreted tracer from the lower urinary tract. (orig.)

Division delay after low x-ray doses and treatment with cyclohexionide

International Nuclear Information System (INIS)

Schneiderman, M.H.; Braby, L.A.; Roesch, W.C.

1977-01-01

Radiation-induced division delay of Chinese hamster ovary cells located in G 2 , and in G 2 between the cycloheximide and x-ray transition points, was measured by the mitotic cell selection technique. The mitotic yield (number of mitotic cells after treatment expressed as a fraction of the control) decreased with increasing radiation dose (4.5 to 34 rad). However, either because some cells were not delayed or because delayed cells recovered rapidly, the mitotic yield did not fall to zero. When cycloheximide was combined with radiation to prevent repair of the radiation damage, only cells which were past the cycloheximide transition point and not delayed by the radiation were selected. The location of the transition points determined from the combined drug plus low-dose radiation (4.5 to 34 rad) experiments indicate a dose-dependent relationship, with more cells delayed as the dose was increased. In addition, the transition point for cells treated with cycloheximide plus 150 rad of x rays was closer to division than the 150 rad of x rays alone. These results are discussed in light of a recent model for radiation-induced division delay proposed by Dewey and Highfield

Development of an acoustic steam generator leak detection system using delay-and-sum beamformer

International Nuclear Information System (INIS)

Chikazawa, Yoshitaka

2009-01-01

A new acoustic steam generator leak detection system using delay-and-sum beamformer is proposed. The major advantage of the delay-and-sum beamformer is it could provide information of acoustic source direction. An acoustic source of a sodium-water reaction is supposed to be localized while the background noise of the steam generator operation is uniformly distributed in the steam generator tube region. Therefore the delay-and-sum beamformer could distinguish the acoustic source of the sodium-water reaction from steam generator background noise. In this paper, results from numerical analyses are provided to show fundamental feasibility of the new method. (author)

Dynamics of a delayed intraguild predation model with harvesting

Science.gov (United States)

Collera, Juancho A.; Balilo, Aldrin T.

2018-03-01

In [1], a delayed three-species intraguild predation (IGP) model was considered. This particular tri-trophic community module includes a predator and its prey which share a common basal resource for their sustenance [3]. Here, it is assumed that in the absence of predation, the growth of the basal resource follows the delayed logistic equation. Without delay time, the IGP model in [1] reduces to the system considered in [7] where it was shown that IGP may induce chaos even if the functional responses are linear. Meanwhile, in [2] the delayed IGP model in [1] was generalized to include harvesting. Under the assumption that the basal resource has some economic value, a constant harvesting term on the basal resource was incorporated. However, both models in [1] and [2] use the delay time as the main parameter. In this research, we studied the delayed IGP model in [1] with the addition of linear harvesting term on each of the three species. The dynamical behavior of this system is examined using the harvesting rates as main parameter. In particular, we give conditions on the existence, stability, and bifurcations of equilibrium solutions of this system. This allows us to better understand the effects of harvesting in terms of the survival or extinction of one or more species in our system. Numerical simulations are carried out to illustrate our results. In fact, we show that the chaotic behavior in [7] unfolds when the harvesting rate parameter is varied.

Clinical Factors of Delayed Perforation after Endoscopic Submucosal Dissection for Gastric Neoplasms

Directory of Open Access Journals (Sweden)

Yoshinobu Yamamoto

2017-01-01

Full Text Available Background. Delayed perforation is a rare but severe complication of endoscopic submucosal dissection (ESD for early gastric neoplasm (EGN. The aim of this study was to clarify clinical factors related to delayed perforation after ESD. Methods. A total of 1158 consecutive patients with 1199 EGNs underwent ESD at our hospital between January 2000 and December 2015. Univariate analysis was used to identify clinicopathological factors related to delayed perforation. Moreover, duration of cautery needed for hemostasis was measured by comparison between perforated and nonperforated points in patients with delayed perforation. Results. Delayed perforation occurred in 5 of 1158 consecutive patients with 1199 EGNs who underwent ESD (0.42%. All cases were diagnosed within 24 h after ESD and recovered with conservative management. On univariate analysis, location in the upper stomach was the factor most significantly associated with delayed perforation (P<0.01. Duration of cautery needed for hemostasis was significantly longer at perforated points (9 s than at nonperforated points (3.5 s in five patients. Conclusions. Location in the upper stomach was the risk factor most prominently associated with delayed perforation after ESD for EGNs. In addition, delayed perforation appears associated with excessive electrocautery for hemostasis.

On the linearity of cross-correlation delay times

Science.gov (United States)

Mercerat, E. D.; Nolet, G.

2012-12-01

major contributor to deviation from linearity. The strong velocity contrast of 10% and the regularity of the anomalous structure generate strong reverberations. The test thus provides a worst-case scenario. The results scale up to regional (upper mantle) seismology if times and distances are multiplied by 10(4) . We conclude that in all but the most extreme cases, P-wave delay times depend quasi-linearly on the model perturbations.

The effect of visual-motion time delays on pilot performance in a pursuit tracking task

Science.gov (United States)

Miller, G. K., Jr.; Riley, D. R.

1976-01-01

A study has been made to determine the effect of visual-motion time delays on pilot performance of a simulated pursuit tracking task. Three interrelated major effects have been identified: task difficulty, motion cues, and time delays. As task difficulty, as determined by airplane handling qualities or target frequency, increases, the amount of acceptable time delay decreases. However, when relatively complete motion cues are included in the simulation, the pilot can maintain his performance for considerably longer time delays. In addition, the number of degrees of freedom of motion employed is a significant factor.

Fundamentals of Delayed Coking Joint Industry Project

Energy Technology Data Exchange (ETDEWEB)

Michael Volk; Keith Wisecarver

2003-09-26

Delayed coking evolved steadily over the early to mid 1900s to enable refiners to convert high boiling, residual petroleum fractions to light products such as gasoline. Pound for pound, coking is the most energy intensive of any operation in a modern refinery. Large amounts of energy are required to heat the thick, poor-quality petroleum residuum to the 900 to 950 degrees F required to crack the heavy hydrocarbon molecules into lighter, more valuable products. One common misconception of delayed coking is that the product coke is a disadvantage. Although coke is a low valued (near zero economic value) byproduct, compared to transportation fuels, there is a significant worldwide trade and demand for coke as it is an economical fuel. Coke production has increased steadily over the last ten years, with further increases forecast for the foreseeable future. Current domestic production is near 111,000 tons per day. A major driving force behind this increase is the steady decline in crude quality available to refiners. Crude slates are expected to grow heavier with higher sulfur contents while environmental restrictions are expected to significantly reduce the demand for high-sulfur residual fuel oil. Light sweet crudes will continue to be available and in even greater demand than they are today. Refiners will be faced with the choice of purchasing light sweet crudes at a premium price, or adding bottom of the barrel upgrading capability, through additional new investments, to reduce the production of high-sulfur residual fuel oil and increase the production of low-sulfur distillate fuels. A second disadvantage is that liquid products from cokers frequently are unstable, i.e., they rapidly form gum and sediments. Because of intermediate investment and operating costs, delayed coking has increased in popularity among refiners worldwide. Based on the 2000 Worldwide Refining Survey published in the Oil and Gas, the delayed coking capacity for 101 refineries around the world

Reward acts as a signal to control delay-period activity in delayed-response tasks.

Science.gov (United States)

Ichihara-Takeda, Satoe; Takeda, Kazuyoshi; Funahashi, Shintaro

2010-03-31

Prefrontal delay-period activity represents a neural mechanism for the active maintenance of information and needs to be controlled by some signal to appropriately operate working memory. To examine whether reward-delivery acts as this signal, the effects of delay-period activity in response to unexpected reward-delivery were examined by analyzing single-neuron activity recorded in the primate dorsolateral prefrontal cortex. Among neurons that showed delay-period activity, 34% showed inhibition of this activity in response to unexpected reward-delivery. The delay-period activity of these neurons was affected by the expectation of reward-delivery. The strength of the reward signal in controlling the delay-period activity is related to the strength of the effect of reward information on the delay-period activity. These results indicate that reward-delivery acts as a signal to control delay-period activity.

Dynamic IQC-Based Control of Uncertain LFT Systems With Time-Varying State Delay.

Science.gov (United States)

Yuan, Chengzhi; Wu, Fen

2016-12-01

This paper presents a new exact-memory delay control scheme for a class of uncertain systems with time-varying state delay under the integral quadratic constraint (IQC) framework. The uncertain system is described as a linear fractional transformation model including a state-delayed linear time-invariant (LTI) system and time-varying structured uncertainties. The proposed exact-memory delay controller consists of a linear state-feedback control law and an additional term that captures the delay behavior of the plant. We first explore the delay stability and the L 2 -gain performance using dynamic IQCs incorporated with quadratic Lyapunov functions. Then, the design of exact-memory controllers that guarantee desired L 2 -gain performance is examined. The resulting delay control synthesis conditions are formulated in terms of linear matrix inequalities, which are convex on all design variables including the scaling matrices associated with the IQC multipliers. The IQC-based exact-memory control scheme provides a novel approach for delay control designs via convex optimization, and advances existing control methods in two important ways: 1) better controlled performance and 2) simplified design procedure with less computational cost. The effectiveness and advantages of the proposed approach have been demonstrated through numerical studies.

Delay-dependent exponential stability of cellular neural networks with time-varying delays

International Nuclear Information System (INIS)

Zhang Qiang; Wei Xiaopeng; Xu Jin

2005-01-01

The global exponential stability of cellular neural networks (CNNs) with time-varying delays is analyzed. Two new sufficient conditions ensuring global exponential stability for delayed CNNs are obtained. The conditions presented here are related to the size of delay. The stability results improve the earlier publications. Two examples are given to demonstrate the effectiveness of the obtained results

Climate models with delay differential equations.

Science.gov (United States)

Keane, Andrew; Krauskopf, Bernd; Postlethwaite, Claire M

2017-11-01

A fundamental challenge in mathematical modelling is to find a model that embodies the essential underlying physics of a system, while at the same time being simple enough to allow for mathematical analysis. Delay differential equations (DDEs) can often assist in this goal because, in some cases, only the delayed effects of complex processes need to be described and not the processes themselves. This is true for some climate systems, whose dynamics are driven in part by delayed feedback loops associated with transport times of mass or energy from one location of the globe to another. The infinite-dimensional nature of DDEs allows them to be sufficiently complex to reproduce realistic dynamics accurately with a small number of variables and parameters. In this paper, we review how DDEs have been used to model climate systems at a conceptual level. Most studies of DDE climate models have focused on gaining insights into either the global energy balance or the fundamental workings of the El Niño Southern Oscillation (ENSO) system. For example, studies of DDEs have led to proposed mechanisms for the interannual oscillations in sea-surface temperature that is characteristic of ENSO, the irregular behaviour that makes ENSO difficult to forecast and the tendency of El Niño events to occur near Christmas. We also discuss the tools used to analyse such DDE models. In particular, the recent development of continuation software for DDEs makes it possible to explore large regions of parameter space in an efficient manner in order to provide a "global picture" of the possible dynamics. We also point out some directions for future research, including the incorporation of non-constant delays, which we believe could improve the descriptive power of DDE climate models.

Climate models with delay differential equations

Science.gov (United States)

Keane, Andrew; Krauskopf, Bernd; Postlethwaite, Claire M.

2017-11-01

A fundamental challenge in mathematical modelling is to find a model that embodies the essential underlying physics of a system, while at the same time being simple enough to allow for mathematical analysis. Delay differential equations (DDEs) can often assist in this goal because, in some cases, only the delayed effects of complex processes need to be described and not the processes themselves. This is true for some climate systems, whose dynamics are driven in part by delayed feedback loops associated with transport times of mass or energy from one location of the globe to another. The infinite-dimensional nature of DDEs allows them to be sufficiently complex to reproduce realistic dynamics accurately with a small number of variables and parameters. In this paper, we review how DDEs have been used to model climate systems at a conceptual level. Most studies of DDE climate models have focused on gaining insights into either the global energy balance or the fundamental workings of the El Niño Southern Oscillation (ENSO) system. For example, studies of DDEs have led to proposed mechanisms for the interannual oscillations in sea-surface temperature that is characteristic of ENSO, the irregular behaviour that makes ENSO difficult to forecast and the tendency of El Niño events to occur near Christmas. We also discuss the tools used to analyse such DDE models. In particular, the recent development of continuation software for DDEs makes it possible to explore large regions of parameter space in an efficient manner in order to provide a "global picture" of the possible dynamics. We also point out some directions for future research, including the incorporation of non-constant delays, which we believe could improve the descriptive power of DDE climate models.

Assessing delay discounting in mice

OpenAIRE

Mitchell, Suzanne H.

2014-01-01

Delay discounting (also intertemporal choice or impulsive choice) is the process by which delayed outcomes, such as delayed food delivery, are valued less than the same outcomes delivered immediately or with a shorter delay. This process is of interest because many psychopathologies, including substance dependence, pathological gambling, attention deficit hyperactivity disorder and conduct disorder, are characterized by heightened levels of delay discounting. Some of these disorders are herit...

Modelling delays in pharmacokinetics

International Nuclear Information System (INIS)

Farooqi, Z.H.; Lambrecht, R.M.

1990-01-01

Linear system analysis has come to form the backbone of pharmacokinetics. Natural systems usually involve time delays, thus models incorporating them would be an order closer approximation to the real world compared to those that do not. Delays may be modelled in several ways. The approach considered in this study is to have a discrete-time delay dependent rate with the delay respresenting the duration between the entry of a drug into a compartment and its release in some form (may be as a metabolite) from the compartment. Such a delay may be because of one or more of several physiological reasons, like, formation of a reservoir, slow metabolism, or receptor binding. The mathematical structure this gives rise to is a system of delay-differential equations. Examples are given of simple one and two compartment systems with drugs like bumetanide, carbamazepine, and quinolone-caffeine interaction. In these examples generally a good fit is obtained and the suggested models form a good approximation. 21 refs., 6 figs

Symmetry, Hopf bifurcation, and the emergence of cluster solutions in time delayed neural networks.

Science.gov (United States)

Wang, Zhen; Campbell, Sue Ann

2017-11-01

We consider the networks of N identical oscillators with time delayed, global circulant coupling, modeled by a system of delay differential equations with Z N symmetry. We first study the existence of Hopf bifurcations induced by the coupling time delay and then use symmetric Hopf bifurcation theory to determine how these bifurcations lead to different patterns of symmetric cluster oscillations. We apply our results to a case study: a network of FitzHugh-Nagumo neurons with diffusive coupling. For this model, we derive the asymptotic stability, global asymptotic stability, absolute instability, and stability switches of the equilibrium point in the plane of coupling time delay (τ) and excitability parameter (a). We investigate the patterns of cluster oscillations induced by the time delay and determine the direction and stability of the bifurcating periodic orbits by employing the multiple timescales method and normal form theory. We find that in the region where stability switching occurs, the dynamics of the system can be switched from the equilibrium point to any symmetric cluster oscillation, and back to equilibrium point as the time delay is increased.

Symmetry, Hopf bifurcation, and the emergence of cluster solutions in time delayed neural networks

Science.gov (United States)

Wang, Zhen; Campbell, Sue Ann

2017-11-01

We consider the networks of N identical oscillators with time delayed, global circulant coupling, modeled by a system of delay differential equations with ZN symmetry. We first study the existence of Hopf bifurcations induced by the coupling time delay and then use symmetric Hopf bifurcation theory to determine how these bifurcations lead to different patterns of symmetric cluster oscillations. We apply our results to a case study: a network of FitzHugh-Nagumo neurons with diffusive coupling. For this model, we derive the asymptotic stability, global asymptotic stability, absolute instability, and stability switches of the equilibrium point in the plane of coupling time delay (τ) and excitability parameter (a). We investigate the patterns of cluster oscillations induced by the time delay and determine the direction and stability of the bifurcating periodic orbits by employing the multiple timescales method and normal form theory. We find that in the region where stability switching occurs, the dynamics of the system can be switched from the equilibrium point to any symmetric cluster oscillation, and back to equilibrium point as the time delay is increased.

Delays in using chromatic and luminance information to correct rapid reaches.

Science.gov (United States)

Kane, Adam; Wade, Alex; Ma-Wyatt, Anna

2011-09-07

People can use feedback to make online corrections to movements but only if there is sufficient time to integrate the new information and make the correction. A key variable in this process is therefore the speed at which the new information about the target location is coded. Conduction velocities for chromatic signals are lower than for achromatic signals so it may take longer to correct reaches to chromatic stimuli. In addition to this delay, the sensorimotor system may prefer achromatic information over the chromatic information as delayed information may be less valuable when movements are made under time pressure. A down-weighting of chromatic information may result in additional latencies for chromatically directed reaches. In our study, participants made online corrections to reaches to achromatic, (L-M)-cone, and S-cone stimuli. Our chromatic stimuli were carefully adjusted to minimize stimulation of achromatic pathways, and we equated stimuli both in terms of detection thresholds and also by their estimated neural responses. Similar stimuli were used throughout the subjective adjustments and final reaching experiment. Using this paradigm, we found that responses to achromatic stimuli were only slightly faster than responses to (L-M)-cone and S-cone stimuli. We conclude that the sensorimotor system treats chromatic and achromatic information similarly and that the delayed chromatic responses primarily reflect early conduction delays.

Clinical usefulness of delayed exercise images on 99mTc-tetrofosmin myocardial SPECT in the diagnosis of vasospastic angina pectoris

International Nuclear Information System (INIS)

Ito, Kazuki; Zen, Kan; Hikosaka, Takatou; Adachi, Yoshihiko; Yoneyama, Satoshi; Katoh, Shuuji; Sugihara, Hiroki; Nakamura, Tomoki; Azuma, Akihiro

2000-01-01

This study was designed to evaluate the clinical usefulness of delayed exercise images in 99m Tc-tetrofosmin (TF) myocardial SPECT in the diagnosis of vasospastic angina pectoris. We studied 30 patients with vasospastic angina, 10 of 30 patients (group A) had both effort and rest angina, 20 of 30 patients (group B) had rest angina. A 370 MBq of TF was intravenously injected at peak exercise, and initial (EX-I) and delayed exercise (EX-D) images were obtained at 30 min and 180 min after the injection. An additional 740 MBq of TF was intravenously reinjected after EX-D image acquisition, and rest images were obtained 30 min after the reinjection. The left ventricular wall was divided into 9 segments. Regional myocardial uptakes of TF were scored by 4-point defect score (0=normal, 1=mildly reduced, 2=moderately reduced, and 3=severely reduced). Total defect score (TDS) was calculated from the sum of defect scores in 9 segments. Reverse redistribution (RR) was defined as increase of more than 2 in TDS on EX-D images. In group A, 4 of 10 cases (40%) showed decreased uptake on EX-I images, 6 of 10 cases (60%) revealed RR on EX-D images, and none of the patients showed decreased uptake on rest images. In group B, no one showed decreased uptake on EX-I and rest images, 11 of 20 cases (55%) revealed RR on EX-D images. The mean±SD of TDS were 2.9±3.4, 5.1±4.5, 0.5±0.5 on EX-I, EX-D, rest images in group A, and serially 0.4±0.5, 3.3±3.6, 0.4±0.5 in group B. Regional wall motion abnormality was reduced in regions with RR. RR on EX-D images may reflect ischemic damaged but viable myocardium in vasospastic angina. The clinical usefulness of exercise-rest TF imaging in detection of organic coronary artery disease has been well established. Therefore, exercise-rest TF imaging with additional delayed exercise image could evaluate not only organic coronary artery disease but also coronary artery vasospasm. (author)

Green Data Gathering under Delay Differentiated Services Constraint for Internet of Things

Directory of Open Access Journals (Sweden)

Mingfeng Huang

2018-01-01

Full Text Available Energy-efficient data gathering techniques play a crucial role in promoting the development of smart portable devices as well as smart sensor devices based Internet of Things (IoT. For data gathering, different applications require different delay constraints; therefore, a delay Differentiated Services based Data Routing (DSDR scheme is creatively proposed to improve the delay differentiated services constraint that is missed from previous data gathering studies. The DSDR scheme has three advantages: first, DSDR greatly reduces transmission delay by establishing energy-efficient routing paths (E2RPs. Multiple E2RPs are established in different locations of the network to forward data, and the duty cycles of nodes on E2RPs are increased to 1, so the data is forwarded by E2RPs without the existence of sleeping delay, which greatly reduces transmission latency. Secondly, DSDR intelligently chooses transmission method according to data urgency: the direct-forwarding strategy is adopted for delay-sensitive data to ensure minimum end-to-end delay, while wait-forwarding method is adopted for delay-tolerant data to perform data fusion for reducing energy consumption. Finally, DSDR make full use of the residual energy and improve the effective energy utilization. The E2RPs are built in the region with adequate residual energy and they are periodically rotated to equalize the energy consumption of the network. A comprehensive performance analysis demonstrates that the DSDR scheme has obvious advantages in improving network performance compared to previous studies: it reduces transmission latency of delay-sensitive data by 44.31%, reduces transmission latency of delay-tolerant data by 25.65%, and improves network energy utilization by 30.61%, while also guaranteeing the network lifetime is not lower than previous studies.

REASONS FOR PATIENT DELAYS & HEALTH SYSTEM DELAYS FOR TUBERCULOSIS IN SOUTH INDIA

Directory of Open Access Journals (Sweden)

Kapil Goel

2011-12-01

Full Text Available Background: Globally, the burden of Tuberculosis is escalating. Early diagnosis and prompt initiation of tuberculosis treatment is essential for an effective tuberculosis control programme. Objectives: To study the self reported reasons for patient and health system (diagnosis & treatment delays in Tuberculosis patients. Methods: A community based cross sectional study was conducted among 98 new sputum positive TB cases aged > 15 years registered under RNTCP from Oct 2006 to June 2007 & receiving treatment under DOTS in Udupi taluk by interviewing them. Results: Total 98 patients were recruited and 68% were males. Out of 17 patients with patient delays, 82% felt that their symptoms were not severe, 71% felt that patient delay was due to lack of awareness and 71% did not take it seriously. Out of 86 patients with health system delays, 82.6% of patients mentioned that doctor has not advised for sputum examination, 76.7% of patients told that they first consulted a private doctor, 21% of them mentioned that doctor was unaware to diagnose TB. Conclusion: Symptoms not severe is the main reason for the patient delay and doctor didn’t advise for sputum examination is the main reason for health system delays.

Delayed recombination and cosmic parameters

International Nuclear Information System (INIS)

Galli, Silvia; Melchiorri, Alessandro; Bean, Rachel; Silk, Joseph

2008-01-01

Current cosmological constraints from cosmic microwave background anisotropies are typically derived assuming a standard recombination scheme, however additional resonance and ionizing radiation sources can delay recombination, altering the cosmic ionization history and the cosmological inferences drawn from the cosmic microwave background data. We show that for recent observations of the cosmic microwave background anisotropy, from the Wilkinson microwave anisotropy probe satellite mission (WMAP) 5-year survey and from the arcminute cosmology bolometer array receiver experiment, additional resonance radiation is nearly degenerate with variations in the spectral index, n s , and has a marked effect on uncertainties in constraints on the Hubble constant, age of the universe, curvature and the upper bound on the neutrino mass. When a modified recombination scheme is considered, the redshift of recombination is constrained to z * =1078±11, with uncertainties in the measurement weaker by 1 order of magnitude than those obtained under the assumption of standard recombination while constraints on the shift parameter are shifted by 1σ to R=1.734±0.028. From the WMAP5 data we obtain the following constraints on the resonance and ionization sources parameters: ε α i <0.058 at 95% c.l.. Although delayed recombination limits the precision of parameter estimation from the WMAP satellite, we demonstrate that this should not be the case for future, smaller angular scales measurements, such as those by the Planck satellite mission.

Delayed orgasm and anorgasmia.

Science.gov (United States)

Jenkins, Lawrence C; Mulhall, John P

2015-11-01

Delayed orgasm/anorgasmia defined as the persistent or recurrent difficulty, delay in, or absence of attaining orgasm after sufficient sexual stimulation, which causes personal distress. Delayed orgasm and anorgasmia are associated with significant sexual dissatisfaction. A focused medical history can shed light on the potential etiologies, which include medications, penile sensation loss, endocrinopathies, penile hyperstimulation, and psychological etiologies. Unfortunately, there are no excellent pharmacotherapies for delayed orgasm/anorgasmia, and treatment revolves largely around addressing potential causative factors and psychotherapy. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Effect of delayed polymerization time and bracket manipulation on orthodontic bracket bonding

Science.gov (United States)

Ponikvar, Michael J.

This study examined the effect of bracket manipulation in combination with delayed polymerization times on orthodontic bracket shear bond strength and degree of resin composite conversion. Orthodontics brackets were bonded to extracted third molars in a simulated oral environment after a set period of delayed polymerization time and bracket manipulation. After curing the bracket adhesive, each bracket underwent shear bond strength testing followed by micro-Raman spectroscopy analysis to measure the degree of conversion of the resin composite. Results demonstrated the shear bond strength and the degree of conversion of ceramic brackets did not vary over time. However, with stainless steel brackets there was a significant effect (p ≤ 0.05) of delay time on shear bond strength between the 0.5 min and 10 min bracket groups. In addition, stainless steel brackets showed significant differences related to degree of conversion over time between the 0.5 min and 5 min groups, in addition to the 0.5 min and 10 min groups. This investigation suggests that delaying bracket adhesive polymerization up to a period of 10 min then adjusting the orthodontic bracket may increase both shear bond strength and degree of conversion of stainless steel brackets while having no effect on ceramic brackets.

Fundamentals of Delayed Coking Joint Industry Project

Energy Technology Data Exchange (ETDEWEB)

Michael Volk Jr; Keith Wisecarver

2005-10-01

Delayed coking evolved steadily over the early to mid 1900s to enable refiners to convert high boiling, residual petroleum fractions to light products such as gasoline. Pound for pound, coking is the most energy intensive of any operation in a modern refinery. Large amounts of energy are required to heat the thick, poor-quality petroleum residuum to the 900 to 950 degrees F required to crack the heavy hydrocarbon molecules into lighter, more valuable products. One common misconception of delayed coking is that the product coke is a disadvantage. Although coke is a low valued (near zero economic value) byproduct, compared to transportation fuels, there is a significant worldwide trade and demand for coke as it is an economical fuel. Coke production has increased steadily over the last ten years, with further increases forecast for the foreseeable future. Current domestic production is near 111,000 tons per day. A major driving force behind this increase is the steady decline in crude quality available to refiners. Crude slates are expected to grow heavier with higher sulfur contents while environmental restrictions are expected to significantly reduce the demand for high-sulfur residual fuel oil. Light sweet crudes will continue to be available and in even greater demand than they are today. Refiners will be faced with the choice of purchasing light sweet crudes at a premium price, or adding bottom of the barrel upgrading capability, through additional new investments, to reduce the production of high-sulfur residual fuel oil and increase the production of low-sulfur distillate fuels. A second disadvantage is that liquid products from cokers frequently are unstable, i.e., they rapidly form gum and sediments. Because of intermediate investment and operating costs, delayed coking has increased in popularity among refiners worldwide. Based on the 2000 Worldwide Refining Survey published in the Oil and Gas, the delayed coking capacity for 101 refineries around the world

Evaluation of Kalman filters and genetic algorithms for delayed-neutron nondestructive assay data analyses

International Nuclear Information System (INIS)

Aumeier, S.E.; Forsmann, J.H.

1998-01-01

The ability to nondestructively determine the presence and quantity of fissile/fertile nuclei in various matrices is important in several areas of nuclear applications, including international and domestic safeguards, radioactive waste characterization, and nuclear facility operations. An analysis was performed to determine the feasibility of identifying the masses of individual fissionable isotopes from a cumulative delayed-neutron signal resulting form the neutron irradiation of several uranium and plutonium isotopes. The feasibility of two separate data-processing techniques was studied: Kalman filtering and genetic algorithms. The basis of each technique is reviewed, and the structure of the algorithms as applied to the delayed-neutron analysis problem is presented. The results of parametric studies performed using several variants of the algorithms are presented. The effect of including additional constraining information such as additional measurements and known relative isotopic concentration is discussed. The parametric studies were conducted using simulated delayed-neutron data representative of the cumulative delayed-neutron response following irradiation of a sample containing 238 U, 235 U, 239 Pu, and 240 Pu. The results show that by processing delayed-neutron data representative of two significantly different fissile/fertile fission ratios, both Kalman filters and genetic algorithms are capable of yielding reasonably accurate estimates of the mass of individual isotopes contained in a given assay sample

A novel perspective to calibrate temporal delays in cerebrovascular reactivity using hypercapnic and hyperoxic respiratory challenges.

Science.gov (United States)

Champagne, Allen A; Bhogal, Alex A; Coverdale, Nicole S; Mark, Clarisse I; Cook, Douglas J

2017-12-05

Redistribution of blood flow across different brain regions, arising from the vasoactive nature of hypercapnia, can introduce errors when examining cerebrovascular reactivity (CVR) response delays. In this study, we propose a novel analysis method to characterize hemodynamic delays in the blood oxygen level dependent (BOLD) response to hypercapnia, and hyperoxia, as a way to provide insight into transient differences in vascular reactivity between cortical regions, and across tissue depths. A pseudo-continuous arterial spin labeling sequence was used to acquire BOLD and cerebral blood flow simultaneously in 19 healthy adults (12 F; 20 ± 2 years) during boxcar CO 2 and O 2 gas inhalation paradigms. Despite showing distinct differences in hypercapnia-induced response delay times (P  0.05) once calibrated for bolus arrival time derived using non-vasoactive hyperoxic gas challenges. Longer hypercapnic temporal delays were observed as the depth of the white matter tissue increased, although no significant differences in response lag were found during hyperoxia across tissue depth, or between grey and white matter. Furthermore, calibration of hypercapnic delays using hyperoxia revealed that deeper white matter layers may be more prone to dynamic redistribution of blood flow, which introduces response lag times ranging between 1 and 3 s in healthy subjects. These findings suggest that the combination of hypercapnic and hyperoxic gas-inhalation MRI can be used to distinguish between differences in CVR that arise as a result of delayed stimulus arrival time (due to the local architecture of the cerebrovasculature), or preferential blood flow distribution. Calibrated response delays to hypercapnia provide important insights into cerebrovascular physiology, and may be used to correct response delays associated with vascular impairment. Copyright © 2017. Published by Elsevier Inc.

A decomposition approach to analysis of competitive-cooperative neural networks with delay

International Nuclear Information System (INIS)

Chu Tianguang; Zhang Zongda; Wang Zhaolin

2003-01-01

Competitive-cooperative or inhibitory-excitatory configurations abound in neural networks. It is demonstrated here how such a configuration may be exploited to give a detailed characterization of the fixed point dynamics in general neural networks with time delay. The idea is to divide the connection weights into inhibitory and excitatory types and thereby to embed a competitive-cooperative delay neural network into an augmented cooperative delay system through a symmetric transformation. This allows for the use of the powerful monotone properties of cooperative systems. By the method, we derive several simple necessary and sufficient conditions on guaranteed trapping regions and guaranteed componentwise (exponential) convergence of the neural networks. The results relate specific decay rate and trajectory bounds to system parameters and are therefore of practical significance in designing a network with desired performance

A Novel Message Scheduling Framework for Delay Tolerant Networks Routing

KAUST Repository

Elwhishi, Ahmed

2013-05-01

Multicopy routing strategies have been considered the most applicable approaches to achieve message delivery in Delay Tolerant Networks (DTNs). Epidemic routing and two-hop forwarding routing are two well-reported approaches for delay tolerant networks routing which allow multiple message replicas to be launched in order to increase message delivery ratio and/or reduce message delivery delay. This advantage, nonetheless, is at the expense of additional buffer space and bandwidth overhead. Thus, to achieve efficient utilization of network resources, it is important to come up with an effective message scheduling strategy to determine which messages should be forwarded and which should be dropped in case of buffer is full. This paper investigates a new message scheduling framework for epidemic and two-hop forwarding routing in DTNs, such that the forwarding/dropping decision can be made at a node during each contact for either optimal message delivery ratio or message delivery delay. Extensive simulation results show that the proposed message scheduling framework can achieve better performance than its counterparts.

Delay-Limited Capacity in the Low Power Regime

KAUST Repository

Rezki, Zouheir

2016-02-11

Outage performance of the M-block fading with additive white Gaussian noise (BF-AWGN) is investigated in the low-power regime. We consider delay-constrained constant-rate communications with perfect channel state information (CSI) at both the transmitter and the receiver (CSI-TR), under a shortterm power constraint (STPC) and a long-term power constraint (LTPC). Subject to STPC, we show that selection diversity that allocates all the power to the strongest block is asymptotically optimal. Then, we provide a simple characterization of the outage probability in the regime of interest. We quantify the reward due to CSI-TR over the constant-rate constant-power scheme and show that this reward increases with the delay constraint. For instance, for Rayleigh fading, we find that a power gain up to 4.3 dB is achievable. Subject to LTPC, we show that the above guidelines still holds and that the outage performance improves due to the flexibility of the LTPC over the STPC. More interestingly, we prove that LTPC allows zero-outage communication even at low SNR and characterize the delaylimited capacity at low SNR in a simple form. More precisely, we establish that the delay-limited capacity scales linearly with the power constraint, for a given M < 1. Our framework highlights the benefit of fading at low SNR as the delay-limited capacity may outperform the AWGN capacity. For instance, for Rayleigh fading and with M = 3, the delay-limited capacity is 16% higher than the capacity of an AWGN channel.

Reliability Of A Novel Intracardiac Electrogram Method For AV And VV Delay Optimization And Comparability To Echocardiography Procedure For Determining Optimal Conduction Delays In CRT Patients

Directory of Open Access Journals (Sweden)

N Reinsch

2009-03-01

Full Text Available Background: Echocardiography is widely used to optimize CRT programming. A novel intracardiac electrogram method (IEGM was recently developed as an automated programmer-based method, designed to calculate optimal atrioventricular (AV and interventricular (VV delays and provide optimized delay values as an alternative to standard echocardiographic assessment.Objective: This study was aimed at determining the reliability of this new method. Furthermore the comparability of IEGM to existing echocardiographic parameters for determining optimal conduction delays was verified.Methods: Eleven patients (age 62.9± 8.7; 81% male; 73% ischemic, previously implanted with a cardiac resynchronisation therapy defibrillator (CRT-D underwent both echocardiographic and IEGM-based delay optimization.Results: Applying the IEGM method, concordance of three consecutively performed measurements was found in 3 (27% patients for AV delay and in 5 (45% patients for VV delay. Intra-individual variation between three measurements as assessed by the IEGM technique was up to 20 ms (AV: n=6; VV: n=4. E-wave, diastolic filling time and septal-to-lateral wall motion delay emerged as significantly different between the echo and IEGM optimization techniques (p < 0.05. The final AV delay setting was significantly different between both methods (echo: 126.4 ± 29.4 ms, IEGM: 183.6 ± 16.3 ms; p < 0.001; correlation: R = 0.573, p = 0.066. VV delay showed significant differences for optimized delays (echo: 46.4 ± 23.8 ms, IEGM: 10.9 ± 7.0 ms; p <0.01; correlation: R = -0.278, p = 0.407.Conclusion: The automated programmer-based IEGM-based method provides a simple and safe method to perform CRT optimization. However, the reliability of this method appears to be limited. Thus, it remains difficult for the examiner to determine the optimal hemodynamic settings. Additionally, as there was no correlation between the optimal AV- and VV-delays calculated by the IEGM method and the echo

Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise.

Science.gov (United States)

Ra, Song-Gyu; Miyazaki, Teruo; Ishikura, Keisuke; Nagayama, Hisashi; Suzuki, Takafumi; Maeda, Seiji; Ito, Masaharu; Matsuzaki, Yasushi; Ohmori, Hajime

2013-01-01

Taurine (TAU) has a lot of the biological, physiological, and pharmocological functions including anti-inflammatory and anti-oxidative stress. Although previous studies have appreciated the effectiveness of branched-chain amino acids (BCAA) on the delayed-onset muscle soreness (DOMS), consistent finding has not still convinced. The aim of this study was to examine the additional effect of TAU with BCAA on the DOMS and muscle damages after eccentric exercise. Thirty-six untrained male volunteers were equally divided into four groups, and ingested a combination with 2.0 g TAU (or placebo) and 3.2 g BCAA (or placebo), thrice a day, 2 weeks prior to and 4 days after elbow flexion eccentric exercise. Following the period after eccentric exercise, the physiological and blood biochemical markers for DOMS and muscle damage showed improvement in the combination of TAU and BCAA supplementation rather than in the single or placebo supplementations. In conclusion, additional supplement of TAU with BCAA would be a useful way to attenuate DOMS and muscle damages induced by high-intensity exercise.

Stability analysis and synchronization in discrete-time complex networks with delayed coupling

Science.gov (United States)

Cheng, Ranran; Peng, Mingshu; Yu, Weibin; Sun, Bo; Yu, Jinchen

2013-12-01

A new network of coupled maps is proposed in which the connections between units involve no delays but the intra-neural communication does, whereas in the work of Atay et al. [Phys. Rev. Lett. 92, 144101 (2004)], the focus is on information processing delayed by the inter-neural communication. We show that the synchronization of the network depends on not only the intrinsic dynamical features and inter-connection topology (characterized by the spectrum of the graph Laplacian) but also the delays and the coupling strength. There are two main findings: (i) the more neighbours, the easier to be synchronized; (ii) odd delays are easier to be synchronized than even ones. In addition, compared with those discussed by Atay et al. [Phys. Rev. Lett. 92, 144101 (2004)], our model has a better synchronizability for regular networks and small-world variants.

Absolute stability of nonlinear systems with time delays and applications to neural networks

Directory of Open Access Journals (Sweden)

Xinzhi Liu

2001-01-01

Full Text Available In this paper, absolute stability of nonlinear systems with time delays is investigated. Sufficient conditions on absolute stability are derived by using the comparison principle and differential inequalities. These conditions are simple and easy to check. In addition, exponential stability conditions for some special cases of nonlinear delay systems are discussed. Applications of those results to cellular neural networks are presented.

Delay-dependent stability of neural networks of neutral type with time delay in the leakage term

International Nuclear Information System (INIS)

Li, Xiaodi; Cao, Jinde

2010-01-01

This paper studies the global asymptotic stability of neural networks of neutral type with mixed delays. The mixed delays include constant delay in the leakage term (i.e. 'leakage delay'), time-varying delays and continuously distributed delays. Based on the topological degree theory, Lyapunov method and linear matrix inequality (LMI) approach, some sufficient conditions are derived ensuring the existence, uniqueness and global asymptotic stability of the equilibrium point, which are dependent on both the discrete and distributed time delays. These conditions are expressed in terms of LMI and can be easily checked by the MATLAB LMI toolbox. Even if there is no leakage delay, the obtained results are less restrictive than some recent works. It can be applied to neural networks of neutral type with activation functions without assuming their boundedness, monotonicity or differentiability. Moreover, the differentiability of the time-varying delay in the non-neutral term is removed. Finally, two numerical examples are given to show the effectiveness of the proposed method

Isolating behavioral mechanisms of intertemporal choice: nicotine effects on delay discounting and amount sensitivity.

Science.gov (United States)

Locey, Matthew L; Dallery, Jesse

2009-03-01

Many drugs of abuse produce changes in impulsive choice, that is, choice for a smaller-sooner reinforcer over a larger-later reinforcer. Because the alternatives differ in both delay and amount, it is not clear whether these drug effects are due to the differences in reinforcer delay or amount. To isolate the effects of delay, we used a titrating delay procedure. In phase 1, 9 rats made discrete choices between variable delays (1 or 19 s, equal probability of each) and a delay to a single food pellet. The computer titrated the delay to a single food pellet until the rats were indifferent between the two options. This indifference delay was used as the starting value for the titrating delay for all future sessions. We next evaluated the acute effects of nicotine (subcutaneous 1.0, 0.3, 0.1, and 0.03 mg/kg) on choice. If nicotine increases delay discounting, it should have increased preference for the variable delay. Instead, nicotine had very little effect on choice. In a second phase, the titrated delay alternative produced three food pellets instead of one, which was again produced by the variable delay (1 s or 19 s) alternative. Under this procedure, nicotine increased preference for the one pellet alternative. Nicotine-induced changes in impulsive choice are therefore likely due to differences in reinforcer amount rather than differences in reinforcer delay. In addition, it may be necessary to include an amount sensitivity parameter in any mathematical model of choice when the alternatives differ in reinforcer amount.

American Dream Delayed

DEFF Research Database (Denmark)

Khorunzhina, Natalia; Miller, Robert A.

This paper investigates the delay in homeownership and a subsequent reduction in homeownership rate observed over the past decades. We focus on the delay in giving birth to children and increased labor market participation as contributing factors to homeownership dynamics for prime-age female hou...

Delayed Orgasm and Anorgasmia

OpenAIRE

Jenkins, Lawrence C.; Mulhall, John P.

2015-01-01

Delayed orgasm/anorgasmia defined as the persistent or recurrent difficulty, delay in, or absence of attaining orgasm after sufficient sexual stimulation, which causes personal distress. Delayed orgasm and anorgasmia are associated with significant sexual dissatisfaction. A focused medical history can shed light on the potential etiologies; which include: medications, penile sensation loss, endocrinopathies, penile hyperstimulation and psychological etiologies, amongst others. Unfortunately, ...

Derivation and computation of discrete-delay and continuous-delay SDEs in mathematical biology.

Science.gov (United States)

Allen, Edward J

2014-06-01

Stochastic versions of several discrete-delay and continuous-delay differential equations, useful in mathematical biology, are derived from basic principles carefully taking into account the demographic, environmental, or physiological randomness in the dynamic processes. In particular, stochastic delay differential equation (SDDE) models are derived and studied for Nicholson's blowflies equation, Hutchinson's equation, an SIS epidemic model with delay, bacteria/phage dynamics, and glucose/insulin levels. Computational methods for approximating the SDDE models are described. Comparisons between computational solutions of the SDDEs and independently formulated Monte Carlo calculations support the accuracy of the derivations and of the computational methods.

Attosecond Delays in Molecular Photoionization.

Science.gov (United States)

Huppert, Martin; Jordan, Inga; Baykusheva, Denitsa; von Conta, Aaron; Wörner, Hans Jakob

2016-08-26

We report measurements of energy-dependent photoionization delays between the two outermost valence shells of N_{2}O and H_{2}O. The combination of single-shot signal referencing with the use of different metal foils to filter the attosecond pulse train enables us to extract delays from congested spectra. Remarkably large delays up to 160 as are observed in N_{2}O, whereas the delays in H_{2}O are all smaller than 50 as in the photon-energy range of 20-40 eV. These results are interpreted by developing a theory of molecular photoionization delays. The long delays measured in N_{2}O are shown to reflect the population of molecular shape resonances that trap the photoelectron for a duration of up to ∼110 as. The unstructured continua of H_{2}O result in much smaller delays at the same photon energies. Our experimental and theoretical methods make the study of molecular attosecond photoionization dynamics accessible.

Stability Switches, Hopf Bifurcations, and Spatio-temporal Patterns in a Delayed Neural Model with Bidirectional Coupling

Science.gov (United States)

Song, Yongli; Zhang, Tonghua; Tadé, Moses O.

2009-12-01

The dynamical behavior of a delayed neural network with bi-directional coupling is investigated by taking the delay as the bifurcating parameter. Some parameter regions are given for conditional/absolute stability and Hopf bifurcations by using the theory of functional differential equations. As the propagation time delay in the coupling varies, stability switches for the trivial solution are found. Conditions ensuring the stability and direction of the Hopf bifurcation are determined by applying the normal form theory and the center manifold theorem. We also discuss the spatio-temporal patterns of bifurcating periodic oscillations by using the symmetric bifurcation theory of delay differential equations combined with representation theory of Lie groups. In particular, we obtain that the spatio-temporal patterns of bifurcating periodic oscillations will alternate according to the change of the propagation time delay in the coupling, i.e., different ranges of delays correspond to different patterns of neural activities. Numerical simulations are given to illustrate the obtained results and show the existence of bursts in some interval of the time for large enough delay.

Variable developmental delays and characteristic facial features-A novel 7p22.3p22.2 microdeletion syndrome?

Science.gov (United States)

Yu, Andrea C; Zambrano, Regina M; Cristian, Ingrid; Price, Sue; Bernhard, Birgitta; Zucker, Marc; Venkateswaran, Sunita; McGowan-Jordan, Jean; Armour, Christine M

2017-06-01

Isolated 7p22.3p22.2 deletions are rarely described with only two reports in the literature. Most other reported cases either involve a much larger region of the 7p arm or have an additional copy number variation. Here, we report five patients with overlapping microdeletions at 7p22.3p22.2. The patients presented with variable developmental delays, exhibiting relative weaknesses in expressive language skills and relative strengths in gross, and fine motor skills. The most consistent facial features seen in these patients included a broad nasal root, a prominent forehead a prominent glabella and arched eyebrows. Additional variable features amongst the patients included microcephaly, metopic ridging or craniosynostosis, cleft palate, cardiac defects, and mild hypotonia. Although the patients' deletions varied in size, there was a 0.47 Mb region of overlap which contained 7 OMIM genes: EIP3B, CHST12, LFNG, BRAT1, TTYH3, AMZ1, and GNA12. We propose that monosomy of this region represents a novel microdeletion syndrome. We recommend that individuals with 7p22.3p22.2 deletions should receive a developmental assessment and a thorough cardiac exam, with consideration of an echocardiogram, as part of their initial evaluation. © 2017 Wiley Periodicals, Inc.

Virtual unit delay for digital frequency adaptive T/4 delay phase-locked loop system

DEFF Research Database (Denmark)

Yang, Yongheng; Zhou, Keliang; Blaabjerg, Frede

2016-01-01

/processor with a fixed sampling rate considering the cost and complexity, where the number of unit delays that have been adopted should be an integer. For instance, in conventional digital control systems, a single-phase T/4 Delay Phase-Locked Loop (PLL) system takes 50 unit delays (i.e., in a 50-Hz system...... Delay PLL system should be done in its implementation. This process will result in performance degradation in the digital control system, as the exactly required number of delays is not realized. Hence, in this paper, a Virtual Unit Delay (VUD) has been proposed to address such challenges to the digital......Digital micro-controllers/processors enable the cost-effective control of grid-connected power converter systems in terms of system monitoring, signal processing (e.g., grid synchronization), control (e.g., grid current and voltage control), etc. Normally, the control is implemented in a micro-controller...

Time delays of supernova neutrinos from new long-range interactions

International Nuclear Information System (INIS)

Malaney, R.A.; Starkman, G.D.; Tremaine, S.

1995-01-01

A new long-range interaction between heavy neutrinos may solve some current problems in large-scale structure, if the new interaction mimics gravity. Assuming that the dark matter is dominated by ∼100 eV τ neutrinos, we investigate whether time delay measurements on supernova neutrinos can test this possibility. We find that such experiments can rule out or detect specific forms of the new interaction potential. In addition, we find the exact dispersive nature of the interacting medium to be critical in determining the time delay: even small corrections to the potential can dramatically alter the magnitude of the effect

Phase-coherence transitions and communication in the gamma range between delay-coupled neuronal populations.

Directory of Open Access Journals (Sweden)

Alessandro Barardi

2014-07-01

Full Text Available Synchronization between neuronal populations plays an important role in information transmission between brain areas. In particular, collective oscillations emerging from the synchronized activity of thousands of neurons can increase the functional connectivity between neural assemblies by coherently coordinating their phases. This synchrony of neuronal activity can take place within a cortical patch or between different cortical regions. While short-range interactions between neurons involve just a few milliseconds, communication through long-range projections between different regions could take up to tens of milliseconds. How these heterogeneous transmission delays affect communication between neuronal populations is not well known. To address this question, we have studied the dynamics of two bidirectionally delayed-coupled neuronal populations using conductance-based spiking models, examining how different synaptic delays give rise to in-phase/anti-phase transitions at particular frequencies within the gamma range, and how this behavior is related to the phase coherence between the two populations at different frequencies. We have used spectral analysis and information theory to quantify the information exchanged between the two networks. For different transmission delays between the two coupled populations, we analyze how the local field potential and multi-unit activity calculated from one population convey information in response to a set of external inputs applied to the other population. The results confirm that zero-lag synchronization maximizes information transmission, although out-of-phase synchronization allows for efficient communication provided the coupling delay, the phase lag between the populations, and the frequency of the oscillations are properly matched.

Global exponential stability of mixed discrete and distributively delayed cellular neural network

International Nuclear Information System (INIS)

Yao Hong-Xing; Zhou Jia-Yan

2011-01-01

This paper concernes analysis for the global exponential stability of a class of recurrent neural networks with mixed discrete and distributed delays. It first proves the existence and uniqueness of the balance point, then by employing the Lyapunov—Krasovskii functional and Young inequality, it gives the sufficient condition of global exponential stability of cellular neural network with mixed discrete and distributed delays, in addition, the example is provided to illustrate the applicability of the result. (general)

Spectral sum rule for time delay in R2

International Nuclear Information System (INIS)

Osborn, T.A.; Sinha, K.B.; Bolle, D.; Danneels, C.

1985-01-01

A local spectral sum rule for nonrelativistic scattering in two dimensions is derived for the potential class velement ofL 4 /sup // 3 (R 2 ). The sum rule relates the integral over all scattering energies of the trace of the time-delay operator for a finite region Σis contained inR 2 to the contributions in Σ of the pure point and singularly continuous spectra

Investigation of the delay time distribution of high power microwave surface flashover

Science.gov (United States)

Foster, J.; Krompholz, H.; Neuber, A.

2011-01-01

Characterizing and modeling the statistics associated with the initiation of gas breakdown has proven to be difficult due to a variety of rather unexplored phenomena involved. Experimental conditions for high power microwave window breakdown for pressures on the order of 100 to several 100 torr are complex: there are little to no naturally occurring free electrons in the breakdown region. The initial electron generation rate, from an external source, for example, is time dependent and so is the charge carrier amplification in the increasing radio frequency (RF) field amplitude with a rise time of 50 ns, which can be on the same order as the breakdown delay time. The probability of reaching a critical electron density within a given time period is composed of the statistical waiting time for the appearance of initiating electrons in the high-field region and the build-up of an avalanche with an inherent statistical distribution of the electron number. High power microwave breakdown and its delay time is of critical importance, since it limits the transmission through necessary windows, especially for high power, high altitude, low pressure applications. The delay time distribution of pulsed high power microwave surface flashover has been examined for nitrogen and argon as test gases for pressures ranging from 60 to 400 torr, with and without external UV illumination. A model has been developed for predicting the discharge delay time for these conditions. The results provide indications that field induced electron generation, other than standard field emission, plays a dominant role, which might be valid for other gas discharge types as well.

The delay effect on outcome evaluation: results from an Event-related Potential study

Directory of Open Access Journals (Sweden)

Chen eQu

2013-11-01

Full Text Available Behavioral studies demonstrate that the timing of receiving gains or losses affects decision-making, a phenomenon known as temporal discounting, as participants are inclined to prefer immediate rewards over delayed ones and vice versa for losses. The present study used the event-related potential (ERP technique with a simple gambling task to investigate how delayed rewards and losses affected the brain activity in outcome evaluations made by 20 young adults. Statistical analysis revealed a larger feedback related negativity (FRN effect between loss and gain following immediate outcomes than following future outcomes. In addition, delay impacted FRN only in gain conditions, with delayed winning eliciting a more negative FRN than immediatewinning. These results suggest that temporal discounting and sign effect could be encoded in the FRN in the early stage of outcome evaluation.

Stability analysis of a class of fractional delay differential equations

Indian Academy of Sciences (India)

In this paper we analyse stability of nonlinear fractional order delay differential equations of the form D y ( t ) = a f ( y ( t − ) ) − by ( t ) , where D is a Caputo fractional derivative of order 0 < ≤ 1. We describe stability regions using critical curves. To explain the proposed theory, we discuss fractional order logistic ...

The energy spectrum of delayed neutrons from thermal neutron induced fission of 235U and its analytical approximation

International Nuclear Information System (INIS)

Doroshenko, A.Yu.; Tarasko, M.Z.; Piksaikin, V.M.

2002-01-01

The energy spectrum of the delayed neutrons is the poorest known of all input data required in the calculation of the effective delayed neutron fractions. In addition to delayed neutron spectra based on the aggregate spectrum measurements there are two different approaches for deriving the delayed neutron energy spectra. Both of them are based on the data related to the delayed neutron spectra from individual precursors of delayed neutrons. In present work these two different data sets were compared with the help of an approximation by gamma-function. The choice of this approximation function instead of the Maxwellian or evaporation type of distribution is substantiated. (author)

Radiation induced late delayed alterations in mice brain after whole body and cranial radiation: a comparative DTI analysis

International Nuclear Information System (INIS)

Watve, Apurva; Gupta, Mamta; Trivedi, Richa; Khushu, Subash; Rana, Poonam

2016-01-01

Moderate dose of radiation exposure occurs during radiation accidents or radiation therapy induces pathophysiological alterations in CNS that may persist for longer duration. Studies suggest that late delayed injury is irreversible leading to metabolic and cognitive impairment. Our earlier studies have illustrated the varied response of brain at acute and early delayed phase on exposure to cranial and whole body radiation. Hence in continuation with our previous studies, present study focuses on comparative microstructural changes in brain at late delayed phase of radiation injury using Diffusion Tensor Imaging (DTI) technique. Region of interest (ROIs) were drawn on corpus callosum (CC), hippocampus (HIP), sensory-motor cortex (SMC), thalamus (TH), hypothalamus (HTH), cingulum (CG), caudeto-putamen (CUP) and cerebral peduncle (CP). The differences in FA (Fractional Anisotropy) and MD (Mean Diffusivity) values generated from these regions of all the groups were evaluated by ANOVA with multiple comparisons using Bonferroni, Post Hoc test. Maximum changes have been observed in MD values mainly in cranial group showing significantly increased MD in CC and SMC region while both the groups showed changes in TH and CUP region as compared to control. FA showed more prominent changes in whole body radiation group than cranial group by decreasing significantly in CP region while in HTH and CUP region in both the groups. Reduced FA indicates compromised structural integrity due to the loss of glial progenitor cells causing transient demyelination while increased MD has been equated with cellular membrane disruption, cell death and vasogenic edema. Thus, present study reveals late delayed CNS response after cranial and whole body radiation exposure. These findings can help us differentiate and monitor the pathophysiological changes at later stages either due to accidental or intentional exposure to ionizing radiation

A novel stabilization condition for T-S polynomial fuzzy system with time-delay:A sum-of-squares approach

OpenAIRE

Tsai, Shun Hung; Chen, Yu-An; Chen, Yu-Wen; Lo, Ji-Chang; Lam, Hak-Keung

2017-01-01

A novel stabilization problem for T-S polynomial fuzzy system with time-delay is investigated in this paper. Firstly, a polynomial fuzzy controller for T-S polynomial fuzzy system with time-delay is proposed. In addition, based on polynomial Lyapunov-Krasovskii function and the developed polynomial slack variable matrices, a novel stabilization condition for T-S polynomial fuzzy system with time-delay is presented in terms of sum-of-square (SOS) form. Lastly, nonlinear system with time-delay ...

Management of delayed nuclear power plant projects

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-09-01

According to the available information at the IAEA PRIS (Power Reactor Information System) at the end of 1998 there were more than 40 nuclear power plant projects with delays of five or more years with respect to the originally scheduled commercial operation. The degree of conformance with original construction schedules showed large variations due to several issues, including financial, economic and public opinion factors. Taking into account the number of projects with several years delay in their original schedules, it was considered useful to identify the subject areas where exchange of experience among Member States would be mutually beneficial in identification of problems and development of guidance for successful management of the completion of these delayed projects. A joint programme of the IAEA Departments of Nuclear Energy (Nuclear Power Engineering Section) and Technical Co-operation (Europe Section, with additional support from the Latin America and West Asia Sections) was set up during the period 1997-1998. The specific aim of the programme was to provide assistance in the management of delayed nuclear power plants regarding measures to maintain readiness for resuming the project implementation schedule when the conditions permit. The integration of IAEA interdepartmental resources enabled the participation of 53 experts from 14 Member States resulting in a wider exchange of experience and dissemination of guidance. Under the framework of the joint programme, senior managers directly responsible for delayed nuclear power plant projects identified several issues or problem areas that needed to be addressed and guidance on management be provided. A work plan for the development of several working documents, addressing the different issues, was established. Subsequently these documents were merged into a single one to produce the present publication. This publication provides information and practical examples on necessary management actions to preserve

Management of delayed nuclear power plant projects

International Nuclear Information System (INIS)

1999-09-01

According to the available information at the IAEA PRIS (Power Reactor Information System) at the end of 1998 there were more than 40 nuclear power plant projects with delays of five or more years with respect to the originally scheduled commercial operation. The degree of conformance with original construction schedules showed large variations due to several issues, including financial, economic and public opinion factors. Taking into account the number of projects with several years delay in their original schedules, it was considered useful to identify the subject areas where exchange of experience among Member States would be mutually beneficial in identification of problems and development of guidance for successful management of the completion of these delayed projects. A joint programme of the IAEA Departments of Nuclear Energy (Nuclear Power Engineering Section) and Technical Co-operation (Europe Section, with additional support from the Latin America and West Asia Sections) was set up during the period 1997-1998. The specific aim of the programme was to provide assistance in the management of delayed nuclear power plants regarding measures to maintain readiness for resuming the project implementation schedule when the conditions permit. The integration of IAEA interdepartmental resources enabled the participation of 53 experts from 14 Member States resulting in a wider exchange of experience and dissemination of guidance. Under the framework of the joint programme, senior managers directly responsible for delayed nuclear power plant projects identified several issues or problem areas that needed to be addressed and guidance on management be provided. A work plan for the development of several working documents, addressing the different issues, was established. Subsequently these documents were merged into a single one to produce the present publication. This publication provides information and practical examples on necessary management actions to preserve

Global exponential stability of reaction-diffusion recurrent neural networks with time-varying delays

International Nuclear Information System (INIS)

Liang Jinling; Cao Jinde

2003-01-01

Employing general Halanay inequality, we analyze the global exponential stability of a class of reaction-diffusion recurrent neural networks with time-varying delays. Several new sufficient conditions are obtained to ensure existence, uniqueness and global exponential stability of the equilibrium point of delayed reaction-diffusion recurrent neural networks. The results extend and improve the earlier publications. In addition, an example is given to show the effectiveness of the obtained result

Delays in switching patients onto second-line antiretroviral treatment ...

African Journals Online (AJOL)

Background: South Africa has one of the largest antiretroviral treatment (ART) programmes globally. In addition to increasing access to ART, it is important that the health system also focuses on the appropriate management of patients who fail first-line ART. Delays in switching patients onto second-line ART can adversely ...

Impulsive control of time-delay systems using delayed impulse and its application to impulsive master-slave synchronization

International Nuclear Information System (INIS)

Sun Jitao; Han Qinglong; Jiang Xiefu

2008-01-01

This Letter is concerned with impulsive control of a class of nonlinear time-delay systems. Some uniform stability criteria for the closed-loop time-delay system under delayed impulsive control are derived by using piecewise Lyapunov functions. Then the criteria are applied to impulsive master-slave synchronization of some secure communication systems with transmission delays and sample delays under delayed impulsive control. Two numerical examples are given to illustrate the effectiveness of the derived results

Additives in crude oil. A new attempt to prevent boilover; Additive im Rohoel. Ein neuer Ansatz zur Vermeidung eines Boilover

Energy Technology Data Exchange (ETDEWEB)

Gosewinkel, Martin; Dworschak, Rene [INBUREX Consulting GmbH, Hamm (Germany)

2011-03-15

Boilover of tanks is a rare cause of serious fires in crude oil storage. The greatest danger is the spill of burning material from the tank. In the research project presented here, a method to prevent boilover and/or reduce its effects was to be developed. One approach is the addition of additives that modify the hetero-azeotropic boiling characteristics of crude oil components in case of fire. Even minimum concentrations of the additive will delay the time until boilover and also reduce its intensity.

Prehospital delay in acute coronary syndrome--an analysis of the components of delay

DEFF Research Database (Denmark)

Ottesen, Michael Mundt; Dixen, Ulrik; Torp-Pedersen, Christian

2004-01-01

BACKGROUND: Prompt hospital admission is essential when treating acute coronary syndrome. Delay prior to admission is unnecessarily long. Therefore, a thorough scrutiny of the influence of characteristics, circumstantial and subjective variables on elements of prehospital delay among patients...... admitted with acute coronary syndrome is warranted. METHODS: A structured interview was conducted on 250 consecutive patients admitted alive with acute coronary syndrome. RESULTS: Median prehospital, decision, physician and transportation delays were 107, 74, 25 and 22 min, respectively. Women (n=77) had...... of acute coronary syndrome among women, and thereby contributes to unnecessary long delay to treatment. The patient's prior experience and interpretation has a significant influence on behaviour....

Communication key using delay times in time-delayed chaos synchronization

International Nuclear Information System (INIS)

Kim, Chil-Min; Kye, Won-Ho; Rim, Sunghwan; Lee, Soo-Young

2004-01-01

We propose an efficient key scheme, which can generate a great number of communication keys, for communication using chaos synchronization. We have attained the keys from delay times of time-delay coupled chaotic systems. We explain the scheme and the efficiency by coupling Henon and logistic maps and illustrate them by coupling Navier-Stokes and Lorenz equations as a continuous system

Delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC): Intra- and Interobserver Variability in Standardized Drawing of Regions of Interest

International Nuclear Information System (INIS)

Tiderius, C.J.; Tjoernstrand, J.; Aakeson, P.; Soedersten, K.; Dahlberg, L.; Leander, P.

2004-01-01

Purpose: To establish the reproducibility of a standardized region of interest (ROI) drawing procedure in delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC). Material and Methods: A large ROI in lateral and medial femoral weight-bearing cartilage was drawn in images of 12 healthy male volunteers by 6 investigators with different skills in MRI. The procedure was done twice, with a 1-week interval. Calculated T1-values were evaluated for intra- and interobserver variability. Results: The mean interobserver variability for both compartments ranged between 1.3% and 2.3% for the 6 different investigators without correlation to their experience in MRI. Post-contrast intra-observer variability was low in both the lateral and the medial femoral cartilage, 2.6% and 1.5%, respectively. The larger variability in lateral than in medial cartilage was related to slightly longer and thinner ROIs. Conclusion: Intra-observer variability and interobserver variability are both low when a large standardized ROI is used in dGEMRIC. The experience of the investigator does not affect the variability, which further supports a clinical applicability of the method

Patient delay is the main cause of treatment delay in acute limb ischemia: an investigation of pre- and in-hospital time delay

DEFF Research Database (Denmark)

Londero, Louise Skovgaard; Nørgaard, Birgitte; Houlind, Kim Christian

2014-01-01

Abstract BACKGROUND: The prognosis of acute limb ischemia is severe, with amputation rates of up to 25% and in-hospital mortality of 9-15%. Delay in treatment increases the risk of major amputation and may be present at different stages, including patient delay, doctors´ delay and waiting time...... in the emergency department. It is important to identify existing problems in order to reduce time delay. The aim of this study was to collect data for patients with acute limb ischemia and to evaluate the time delay between the different events from onset of symptoms to specialist evaluation and further treatment...... (median (range)) was identified. From onset of symptoms to first contact with a doctor the time for all patients were 24 (0-1200) hours. Thirty patients needed immediate intervention. In the group of fourteen patients who had immediate operation, the median time from vascular evaluation...

Barriers and Delays in Tuberculosis Diagnosis and Treatment Services: Does Gender Matter?

Directory of Open Access Journals (Sweden)

Wei-Teng Yang

2014-01-01

Full Text Available Background. Tuberculosis (TB remains a global public health problem with known gender-related disparities. We reviewed the quantitative evidence for gender-related differences in accessing TB services from symptom onset to treatment initiation. Methods. Following a systematic review process, we: searched 12 electronic databases; included quantitative studies assessing gender differences in accessing TB diagnostic and treatment services; abstracted data; and assessed study validity. We defined barriers and delays at the individual and provider/system levels using a conceptual framework of the TB care continuum and examined gender-related differences. Results. Among 13,448 articles, 137 were included: many assessed individual-level barriers (52% and delays (42%, 76% surveyed persons presenting for care with diagnosed or suspected TB, 24% surveyed community members, and two-thirds were from African and Asian regions. Many studies reported no gender differences. Among studies reporting disparities, women faced greater barriers (financial: 64% versus 36%; physical: 100% versus 0%; stigma: 85% versus 15%; health literacy: 67% versus 33%; and provider-/system-level: 100% versus 0% and longer delays (presentation to diagnosis: 45% versus 0% than men. Conclusions. Many studies found no quantitative gender-related differences in barriers and delays limiting access to TB services. When differences were identified, women experienced greater barriers and longer delays than men.

Barriers and delays in tuberculosis diagnosis and treatment services: does gender matter?

Science.gov (United States)

Yang, Wei-Teng; Gounder, Celine R; Akande, Tokunbo; De Neve, Jan-Walter; McIntire, Katherine N; Chandrasekhar, Aditya; de Lima Pereira, Alan; Gummadi, Naveen; Samanta, Santanu; Gupta, Amita

2014-01-01

Background. Tuberculosis (TB) remains a global public health problem with known gender-related disparities. We reviewed the quantitative evidence for gender-related differences in accessing TB services from symptom onset to treatment initiation. Methods. Following a systematic review process, we: searched 12 electronic databases; included quantitative studies assessing gender differences in accessing TB diagnostic and treatment services; abstracted data; and assessed study validity. We defined barriers and delays at the individual and provider/system levels using a conceptual framework of the TB care continuum and examined gender-related differences. Results. Among 13,448 articles, 137 were included: many assessed individual-level barriers (52%) and delays (42%), 76% surveyed persons presenting for care with diagnosed or suspected TB, 24% surveyed community members, and two-thirds were from African and Asian regions. Many studies reported no gender differences. Among studies reporting disparities, women faced greater barriers (financial: 64% versus 36%; physical: 100% versus 0%; stigma: 85% versus 15%; health literacy: 67% versus 33%; and provider-/system-level: 100% versus 0%) and longer delays (presentation to diagnosis: 45% versus 0%) than men. Conclusions. Many studies found no quantitative gender-related differences in barriers and delays limiting access to TB services. When differences were identified, women experienced greater barriers and longer delays than men.

Ignition delay time correlation of fuel blends based on Livengood-Wu description

KAUST Repository

Khaled, Fathi

2017-08-17

In this work, a universal methodology for ignition delay time (IDT) correlation of multicomponent fuel mixtures is reported. The method is applicable over wide ranges of temperatures, pressures, and equivalence ratios. n-Heptane, iso-octane, toluene, ethanol and their blends are investigated in this study because of their relevance to gasoline surrogate formulation. The proposed methodology combines benefits from the Livengood-Wu integral, the cool flame characteristics and the Arrhenius behavior of the high-temperature ignition delay time to suggest a simple and comprehensive formulation for correlating the ignition delay times of pure components and blends. The IDTs of fuel blends usually have complex dependences on temperature, pressure, equivalence ratio and composition of the blend. The Livengood-Wu integral is applied here to relate the NTC region and the cool flame phenomenon. The integral is further extended to obtain a relation between the IDTs of fuel blends and pure components. Ignition delay times calculated using the proposed methodology are in excellent agreement with those simulated using a detailed chemical kinetic model for n-heptane, iso-octane, toluene, ethanol and blends of these components. Finally, very good agreement is also observed for combustion phasing in homogeneous charge compression ignition (HCCI) predictions between simulations performed with detailed chemistry and calculations using the developed ignition delay correlation.

Vehicle barrier with access delay

Science.gov (United States)

Swahlan, David J; Wilke, Jason

2013-09-03

An access delay vehicle barrier for stopping unauthorized entry into secure areas by a vehicle ramming attack includes access delay features for preventing and/or delaying an adversary from defeating or compromising the barrier. A horizontally deployed barrier member can include an exterior steel casing, an interior steel reinforcing member and access delay members disposed within the casing and between the casing and the interior reinforcing member. Access delay members can include wooden structural lumber, concrete and/or polymeric members that in combination with the exterior casing and interior reinforcing member act cooperatively to impair an adversarial attach by thermal, mechanical and/or explosive tools.

Burn Delay Analysis of the Lunar Orbit Insertion for Korea Pathfinder Lunar Orbiter

Science.gov (United States)

Bae, Jonghee; Song, Young-Joo; Kim, Young-Rok; Kim, Bangyeop

2017-12-01

The first Korea lunar orbiter, Korea Pathfinder Lunar Orbiter (KPLO), has been in development since 2016. After launch, the KPLO will execute several maneuvers to enter into the lunar mission orbit, and will then perform lunar science missions for one year. Among these maneuvers, the lunar orbit insertion (LOI) is the most critical maneuver because the KPLO will experience an extreme velocity change in the presence of the Moon’s gravitational pull. However, the lunar orbiter may have a delayed LOI burn during operation due to hardware limitations and telemetry delays. This delayed burn could occur in different captured lunar orbits; in the worst case, the KPLO could fly away from the Moon. Therefore, in this study, the burn delay for the first LOI maneuver is analyzed to successfully enter the desired lunar orbit. Numerical simulations are performed to evaluate the difference between the desired and delayed lunar orbits due to a burn delay in the LOI maneuver. Based on this analysis, critical factors in the LOI maneuver, the periselene altitude and orbit period, are significantly changed and an additional delta-V in the second LOI maneuver is required as the delay burn interval increases to 10 min from the planned maneuver epoch.

Labeling and effectiveness testing; sunscreen drug products for over-the-counter human use; delay of compliance dates. Final rule; delay of compliance dates; request for comments.

Science.gov (United States)

2012-05-11

The Food and Drug Administration (FDA) is delaying the compliance dates for the final rule for over-the-counter (OTC) sunscreen drug products that published in the Federal Register of June 17, 2011 (76 FR 35620). The final rule establishes labeling and effectiveness testing for certain OTC sunscreen products containing specified active ingredients and marketed without approved applications. It also amends labeling claims that are not currently supported by data and lifts the previously-published delay of implementation of the Drug Facts labeling requirements for OTC sunscreens. The 2011 final rule's compliance dates are being delayed because information received after publication of the 2011 final rule indicates that full implementation of the 2011 final rule's requirements for all affected products will require an additional 6 months. This final rule is part of FDA's ongoing review of OTC drug products.

A ternary logic model for recurrent neuromime networks with delay.

Science.gov (United States)

Hangartner, R D; Cull, P

1995-07-01

In contrast to popular recurrent artificial neural network (RANN) models, biological neural networks have unsymmetric structures and incorporate significant delays as a result of axonal propagation. Consequently, biologically inspired neural network models are more accurately described by nonlinear differential-delay equations rather than nonlinear ordinary differential equations (ODEs), and the standard techniques for studying the dynamics of RANNs are wholly inadequate for these models. This paper develops a ternary-logic based method for analyzing these networks. Key to the technique is the realization that a nonzero delay produces a bounded stability region. This result significantly simplifies the construction of sufficient conditions for characterizing the network equilibria. If the network gain is large enough, each equilibrium can be classified as either asymptotically stable or unstable. To illustrate the analysis technique, the swim central pattern generator (CPG) of the sea slug Tritonia diomedea is examined. For wide range of reasonable parameter values, the ternary analysis shows that none of the network equilibria are stable, and thus the network must oscillate. The results show that complex synaptic dynamics are not necessary for pattern generation.

Improving Delay-Range-Dependent Stability Condition for Systems with Interval Time-Varying Delay

Directory of Open Access Journals (Sweden)

Wei Qian

2013-01-01

Full Text Available This paper discusses the delay-range-dependent stability for systems with interval time-varying delay. Through defining the new Lyapunov-Krasovskii functional and estimating the derivative of the LKF by introducing new vectors, using free matrices and reciprocally convex approach, the new delay-range-dependent stability conditions are obtained. Two well-known examples are given to illustrate the less conservatism of the proposed theoretical results.

Use of one delayed-neutron precursor group in transient analysis

International Nuclear Information System (INIS)

Diamond, D.J.

1983-01-01

In most reactor dynamics calculations six groups of delayed-neutron precursors are usually accounted for. However, under certain circumstances it may be advantageous to simplify the calculation and utilize a single delayed-neutron group. The motivation for going to one precursor group is economy. For LWR transient codes that use point kinetics the equations are solved very rapidly and six precursor groups should always be used. However, codes with spatially dependent neutron kinetics are very long running and the use of one precursor group may save computer costs and not impair the accuracy of the results significantly. Furthermore, in some codes, the elimation of five presursor groups makes additional memory available which may be used to give a net increase in the accuracy of the calculations, e.g., by allowing for an increase in mesh density. In order to use one delayed neutron precursor group it is necessary to derive a single decay constant, 6 lambda-, which, along with the total (or one group) delayed neutron fraction β = Σ/sub i = 1/β/sub i/, will adequately describe the transeint precursor behavior. The present summary explains how a recommendation for lambda- was derived

A delay fractioning approach to global synchronization of delayed complex networks with stochastic disturbances

International Nuclear Information System (INIS)

Wang Yao; Wang Zidong; Liang Jinling

2008-01-01

In this Letter, the synchronization problem is investigated for a class of stochastic complex networks with time delays. By utilizing a new Lyapunov functional form based on the idea of 'delay fractioning', we employ the stochastic analysis techniques and the properties of Kronecker product to establish delay-dependent synchronization criteria that guarantee the globally asymptotically mean-square synchronization of the addressed delayed networks with stochastic disturbances. These sufficient conditions, which are formulated in terms of linear matrix inequalities (LMIs), can be solved efficiently by the LMI toolbox in Matlab. The main results are proved to be much less conservative and the conservatism could be reduced further as the number of delay fractioning gets bigger. A simulation example is exploited to demonstrate the advantage and applicability of the proposed result

A distributed delay approach for modeling delayed outcomes in pharmacokinetics and pharmacodynamics studies.

Science.gov (United States)

Hu, Shuhua; Dunlavey, Michael; Guzy, Serge; Teuscher, Nathan

2018-04-01

A distributed delay approach was proposed in this paper to model delayed outcomes in pharmacokinetics and pharmacodynamics studies. This approach was shown to be general enough to incorporate a wide array of pharmacokinetic and pharmacodynamic models as special cases including transit compartment models, effect compartment models, typical absorption models (either zero-order or first-order absorption), and a number of atypical (or irregular) absorption models (e.g., parallel first-order, mixed first-order and zero-order, inverse Gaussian, and Weibull absorption models). Real-life examples were given to demonstrate how to implement distributed delays in Phoenix ® NLME™ 8.0, and to numerically show the advantages of the distributed delay approach over the traditional methods.

Novel delay-distribution-dependent stability analysis for continuous-time recurrent neural networks with stochastic delay

International Nuclear Information System (INIS)

Wang Shen-Quan; Feng Jian; Zhao Qing

2012-01-01

In this paper, the problem of delay-distribution-dependent stability is investigated for continuous-time recurrent neural networks (CRNNs) with stochastic delay. Different from the common assumptions on time delays, it is assumed that the probability distribution of the delay taking values in some intervals is known a priori. By making full use of the information concerning the probability distribution of the delay and by using a tighter bounding technique (the reciprocally convex combination method), less conservative asymptotic mean-square stable sufficient conditions are derived in terms of linear matrix inequalities (LMIs). Two numerical examples show that our results are better than the existing ones. (general)

Time Delay of CGM Sensors

Science.gov (United States)

Schmelzeisen-Redeker, Günther; Schoemaker, Michael; Kirchsteiger, Harald; Freckmann, Guido; Heinemann, Lutz; del Re, Luigi

2015-01-01

Background: Continuous glucose monitoring (CGM) is a powerful tool to support the optimization of glucose control of patients with diabetes. However, CGM systems measure glucose in interstitial fluid but not in blood. Rapid changes in one compartment are not accompanied by similar changes in the other, but follow with some delay. Such time delays hamper detection of, for example, hypoglycemic events. Our aim is to discuss the causes and extent of time delays and approaches to compensate for these. Methods: CGM data were obtained in a clinical study with 37 patients with a prototype glucose sensor. The study was divided into 5 phases over 2 years. In all, 8 patients participated in 2 phases separated by 8 months. A total number of 108 CGM data sets including raw signals were used for data analysis and were processed by statistical methods to obtain estimates of the time delay. Results: Overall mean (SD) time delay of the raw signals with respect to blood glucose was 9.5 (3.7) min, median was 9 min (interquartile range 4 min). Analysis of time delays observed in the same patients separated by 8 months suggests a patient dependent delay. No significant correlation was observed between delay and anamnestic or anthropometric data. The use of a prediction algorithm reduced the delay by 4 minutes on average. Conclusions: Prediction algorithms should be used to provide real-time CGM readings more consistent with simultaneous measurements by SMBG. Patient specificity may play an important role in improving prediction quality. PMID:26243773

Delay-Dependent Guaranteed Cost Control of an Interval System with Interval Time-Varying Delay

Directory of Open Access Journals (Sweden)

Xiao Min

2009-01-01

Full Text Available This paper concerns the problem of the delay-dependent robust stability and guaranteed cost control for an interval system with time-varying delay. The interval system with matrix factorization is provided and leads to less conservative conclusions than solving a square root. The time-varying delay is assumed to belong to an interval and the derivative of the interval time-varying delay is not a restriction, which allows a fast time-varying delay; also its applicability is broad. Based on the Lyapunov-Ktasovskii approach, a delay-dependent criterion for the existence of a state feedback controller, which guarantees the closed-loop system stability, the upper bound of cost function, and disturbance attenuation lever for all admissible uncertainties as well as out perturbation, is proposed in terms of linear matrix inequalities (LMIs. The criterion is derived by free weighting matrices that can reduce the conservatism. The effectiveness has been verified in a number example and the compute results are presented to validate the proposed design method.

Delay-Dependent Control for Networked Control Systems with Large Delays

Directory of Open Access Journals (Sweden)

Yilin Wang

2013-01-01

Full Text Available We consider the problems of robust stability and control for a class of networked control systems with long-time delays. Firstly, a nonlinear discrete time model with mode-dependent time delays is proposed by converting the uncertainty of time delay into the uncertainty of parameter matrices. We consider a probabilistic case where the system is switched among different subsystems, and the probability of each subsystem being active is defined as its occurrence probability. For a switched system with a known subsystem occurrence probabilities, we give a stochastic stability criterion in terms of linear matrix inequalities (LMIs. Then, we extend the results to a more practical case where the subsystem occurrence probabilities are uncertain. Finally, a simulation example is presented to show the efficacy of the proposed method.

Neuro-economics in chicks: foraging choices based on amount, delay and cost.

Science.gov (United States)

Matsushima, Toshiya; Kawamori, Ai; Bem-Sojka, Tiaza

2008-06-15

Studies on the foraging choices are reviewed, with an emphasis on the neural representations of elementary factors of food (i.e., amount, delay and consumption time) in the avian brain. Domestic chicks serve as an ideal animal model in this respect, as they quickly associate cue colors with subsequently supplied food rewards, and their choices are quantitatively linked with the rewards. When a pair of such color cues was simultaneously presented, the trained chicks reliably made choices according to the profitability of food associated with each color. Two forebrain regions are involved in distinct aspects of choices; i.e., nucleus accumbens-medial striatum (Ac-MSt) and arcopallium intermedium (AI), an association area in the lateral forebrain. Localized lesions of Ac-MSt enhanced delay aversion, and the ablated chicks made impulsive choices of immediate reward more frequently than sham controls. On the other hand, lesions of AI enhanced consumption-time aversion, and the ablated chicks shifted their choices toward easily consumable reward with their impulsiveness unchanged; delay and consumption time are thus doubly dissociated. Furthermore, chicks showed distinct patterns of risk-sensitive choices depending on the factor that varied at trials. Risk aversion occurred when food amount varied, whereas consistent risk sensitivity was not found when the delay varied; amount and delay were not interchangeable. Choices are thus deviated from those predicted as optima. Instead, factors such as amount, delay and consumption time could be separately represented and processed to yield economically sub-optimal choices.

Quad nanosecond delay module

International Nuclear Information System (INIS)

McDonald, R.J.; Hunter, J.B.; Wozniak, G.J.

1986-04-01

Four nanosecond (ns) delay units have been designed to fit in a single-width NIM module. This module is particularly suited for use in conjunction with quad constant fraction timing discriminators (CFTDs) since it has four delay units that can be placed adjacent to the four units of the CFTD. A series of different length cables connected via DIP toggle switches provide delays of 0.60 ns in 4 ns increments. Thus, the CFTD delay can be optimized for pulses of different rise times from approx.10-100 ns. Design work for the PC board and silkscreening of the front panel were done with the MacDraw program on the Apple Mackintosh computer and printed with the Lasewriter printer. 6 refs

Stability analysis of a class of fractional delay differential equations

Indian Academy of Sciences (India)

Abstract. In this paper we analyse stability of nonlinear fractional order delay differential equa- tions of the form Dα y(t) = af (y(t − τ )) − by(t), where Dα is a Caputo fractional derivative of order 0 < α ≤ 1. We describe stability regions using critical curves. To explain the proposed theory, we discuss fractional order logistic ...

Robustness of unstable attractors in arbitrarily sized pulse-coupled networks with delay

NARCIS (Netherlands)

Broer, Hendrik; Efstathiou, Konstantinos; Subramanian, Easwar

We consider arbitrarily large networks of pulse-coupled oscillators with non-zero delay where the coupling is given by the Mirollo-Strogatz function. We prove that such systems have unstable attractors (saddle periodic orbits whose stable set has non-empty interior) in an open parameter region for

Delayed Hospital Discharges of Older Patients: A Systematic Review on Prevalence and Costs.

Science.gov (United States)

Landeiro, Filipa; Roberts, Kenny; Gray, Alastair Mcintosh; Leal, José

2017-05-23

To determine the prevalence of delayed discharges of elderly inpatients and associated costs. We searched Medline, Embase, Global Health, CAB Abstracts, Econlit, Web of Knowledge, EBSCO - CINAHL, The Cochrane Library, Health Management Information Consortium, and SCIE - Social Care Online for evidence published between 1990 and 2015 on number of days or proportion of delayed discharges for elderly inpatients in acute hospitals. Descriptive and regression analyses were conducted. Data on proportions of delayed discharges were pooled using a random effects logistic model and the association of relevant factors was assessed. Mean costs of delayed discharge were calculated in USD adjusted for Purchasing Power Parity (PPP). Of 64 studies included, 52 (81.3%) reported delayed discharges as proportions of total hospital stay and 9 (14.1%) estimated the respective costs for these delays. Proportions of delayed discharges varied widely, from 1.6% to 91.3% with a weighted mean of 22.8%. This variation was also seen in studies from the same country, for example, in the United Kingdom, they ranged between 1.6% and 60.0%. No factor was found to be significantly associated with delays. The mean costs of delayed discharge also varied widely (between 142 and 31,935 USD PPP adjusted), reflecting the variability in mean days of delay per patient. Delayed discharges occur in most countries and the associated costs are significant. However, the variability in prevalence of delayed discharges and available data on costs limit our knowledge of the full impact of delayed discharges. A standardization of methods is necessary to allow comparisons to be made, and additional studies are required-preferably by disease area-to determine the postdischarge needs of specific patient groups and the estimated costs of delays. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Specific diagnosis of hepatocellular carcinoma by delayed hepatobiliary imaging

International Nuclear Information System (INIS)

Hasegawa, Y.; Nakano, S.; Ibuka, K.

1986-01-01

For assessment of the value of delayed hepatobiliary imaging with technetium 99m (/sup 99m/Tc)-(Sn)-N-pyridoxyl-5-methyltryptophan (/sup 99m/Tc-PMT) for specific diagnosis of hepatocellular carcinoma, 88 patients with various malignant and benign liver diseases (49 with hepatocellular carcinoma, 4 with cholangiocellular carcinoma, 10 with metastatic liver carcinoma, 2 with liver cysts, 2 with liver hemangioma, 1 with liver abscess, 2 with intrahepatic lithiasis, 12 with liver cirrhosis, and 6 with chronic hepatitis) were studied. In 20 (41%) of the 49 patients with hepatocellular carcinoma, greater uptake of /sup 99m/Tc-PMT by the tumor than by the surrounding liver tissue was seen in delayed hepatobiliary images, whereas in eight patients (16%), equilibrated uptake was seen. No increased uptake of the radioisotope by hepatic lesions was seen in 21 patients with localized liver diseases other than hepatoma. Moreover, in 18 patients with diffuse liver diseases, no focal accumulation of the radioisotope was seen in delayed /sup 99m/Tc-PMT images. In addition, of 28 patients with hepatocellular carcinoma in whom the serum alpha-fetoprotein level showed little or no increase, 12 showed increased uptake of /sup 99m/Tc-PMT by the tumor. In assessing delayed /sup 99m/Tc-PMT images, however, it was necessary to consider following complications: accumulation of tracer in obstructed and dilated biliary trees; retention of radioactivity in nonneoplastic liver tissues; difficulties in evaluating /sup 99m/Tc-PMT uptake by small hepatic tumors; overlapping of radioactivity in the gut and gallbladder in delayed /sup 99m/Tc-PMT images of tumors. This study indicates that delayed /sup 99m/Tc-PMT images can be useful in the diagnosis of hepatocellular carcinoma

Delayed addition of nitrogen-rich substrates during composting of municipal waste

DEFF Research Database (Denmark)

Nigatu, Abebe Nigussie; Bruun, Sander; Kuyper, Thomas W.

2017-01-01

-rich substrate (poultry manure) on nitrogen losses and greenhouse gas emissions during composting and to link this effect to different bulking agents (coffee husks and sawdust), and (ii) to assess the effect of split addition of a nitrogen-rich substrate on compost stability and sanitisation. The results showed...

Prescription Drug Marketing Act of 1987; Prescription Drug Amendments of 1992; policies, requirements, and administrative procedures; delay of effective date. Final rule; delay of effective date.

Science.gov (United States)

2004-02-23

. Sec. 203.3(u) and 203.50 (21 CFR 203.3(u) and 203.50) until December 1, 2007 to allow stakeholders time to continue to move toward this goal. In addition, the further delay of the applicability of Sec. 203.3(q) to wholesale distribution of blood derivatives by health care entities is necessary to give the agency additional time to consider whether regulatory changes are appropriate and, if so, to initiate such changes.

Risk factors of delayed ulcer healing after gastric endoscopic submucosal dissection.

Science.gov (United States)

Lim, Joo Hyun; Kim, Sang Gyun; Choi, Jeongmin; Im, Jong Pil; Kim, Joo Sung; Jung, Hyun Chae

2015-12-01

Although post-endoscopic submucosal dissection (ESD) iatrogenic ulcer is known to heal faster than peptic ulcer, some iatrogenic ulcers show delayed healing. The aim of this study was to clarify risk factors of delayed ulcer healing after gastric ESD. We retrospectively reviewed medical records of all patients who had ESD for gastric neoplasms (866 adenomas and 814 early gastric cancers) between January 2005 and February 2011. Of 1680 subjects, 95 had delayed ulcer healing in 3-month follow-up. Multivariate analysis showed that diabetes (OR 1.743; 95% CI 1.017-2.989, p = 0.043), coagulation abnormality (OR 3.195; 95% CI 1.535-6.650, p = 0.002), specimen size greater than 4 cm (OR 2.999; 95% CI 1.603-5.611, p = 0.001), and electrocoagulation (OR 7.149; 95% CI 1.738-29.411, p = 0.006) were revealed to be independent risk factors of delayed ulcer healing. Meanwhile, persistent Helicobacter pylori infection was not related to the delayed ulcer healing. Large iatrogenic ulcer by ESD with massive hemostasis, especially in patients with diabetes mellitus or coagulation abnormalities, tends to take more than 3 months to heal. For such cases, initial dosage increment of PPI or addition of other anti-ulcer agents after ESD may be beneficial.

UAVs and Control Delays

National Research Council Canada - National Science Library

de Vries, S. C

2005-01-01

.... Delays of about 250-300 ms often lead to unacceptable airplane handling qualities. Techniques such as filtering and predictive displays may extend the range of acceptable delays up to about 400 ms...

Analytical applications for delayed neutrons

International Nuclear Information System (INIS)

Eccleston, G.W.

1983-01-01

Analytical formulations that describe the time dependence of neutron populations in nuclear materials contain delayed-neutron dependent terms. These terms are important because the delayed neutrons, even though their yields in fission are small, permit control of the fission chain reaction process. Analytical applications that use delayed neutrons range from simple problems that can be solved with the point reactor kinetics equations to complex problems that can only be solved with large codes that couple fluid calculations with the neutron dynamics. Reactor safety codes, such as SIMMER, model transients of the entire reactor core using coupled space-time neutronics and comprehensive thermal-fluid dynamics. Nondestructive delayed-neutron assay instruments are designed and modeled using a three-dimensional continuous-energy Monte Carlo code. Calculations on high-burnup spent fuels and other materials that contain a mix of uranium and plutonium isotopes require accurate and complete information on the delayed-neutron periods, yields, and energy spectra. A continuing need exists for delayed-neutron parameters for all the fissioning isotopes

Delay-Dependent Stability Analysis of Uncertain Fuzzy Systems with State and Input Delays under Imperfect Premise Matching

Directory of Open Access Journals (Sweden)

Zejian Zhang

2013-01-01

Full Text Available This paper discusses the stability and stabilization problem for uncertain T-S fuzzy systems with time-varying state and input delays. A new augmented Lyapunov function with an additional triple-integral term and different membership functions of the fuzzy models and fuzzy controllers are introduced to derive the stability criterion, which is less conservative than the existing results. Moreover, a new flexibility design method is also provided. Some numerical examples are given to demonstrate the effectiveness and less conservativeness of the proposed method.

49 CFR 236.563 - Delay time.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Delay time. 236.563 Section 236.563 Transportation... Cab Signal Systems Rules and Instructions; Locomotives § 236.563 Delay time. Delay time of automatic... requirements of § 236.24 shall take into consideration the delay time. ...

Coping with persistent environmental problems: systemic delays in reducing eutrophication of the Baltic Sea

Directory of Open Access Journals (Sweden)

Riku Varjopuro

2014-12-01

Full Text Available In this paper we focus on systemic delays in the Baltic Sea that cause the problem of eutrophication to persist. These problems are demonstrated in our study by addressing three types of delays: (1 decision delay: the time it takes for an idea or perceived need to be launched as a policy; (2 implementation delay: the time from the launch of a policy to the actual implementation; (3 ecosystem delay: the time difference between the implementation and an actual measurable effects. A policy process is one characterized by delays. It may take years from problem identification to a decision to taking action and several years further for actual implementation. Ecosystem responses to measures illustrate that feedback can keep the ecosystem in a certain state and cause a delay in ecosystem response. These delays can operate on decadal scales. Our aim in this paper is to analyze these systemic delays and especially to discuss how the critical delays can be better addressed in marine protection policies by strengthening the adaptive capacity of marine protection. We conclude that the development of monitoring systems and reflexive, participatory analysis of dynamics involved in the implementation are keys to improve understanding of the systemic delays. The improved understanding is necessary for the adaptive management of a persistent environmental problem. In addition to the state of the environment, the monitoring and analysis should be targeted also at the implementation of policies to ensure that the societies are investing in the right measures.

Delayed puberty in boys

Science.gov (United States)

... page: //medlineplus.gov/ency/article/007695.htm Delayed puberty in boys To use the sharing features on this page, please enable JavaScript. Delayed puberty in boys is when puberty does not begin ...

[Delayed adverse reactions to blood donation: From haemovigilance data to specific studies].

Science.gov (United States)

Py, J-Y; Durieux, S; Barnoux, M; Sapey, T

2016-11-01

Delayed adverse reactions to blood donation occur after the donor left donation site. Their intrinsic gravity and possible complications can be increased by the fact the donor is alone. This can also increase bad memories, leading to a donation giving up. Blood transfusion centre is only aware in case of donor feedback, hence an event underrating. We choose to compare our data upon delayed adverse donor reactions with those we could find in past studies. A first data level comes from French haemovigilance data while serious adverse reactions declaration is mandatory. But a second level can be reached using blood transfusion centre computerized data because all the donation reactions are saved whatever the gravity is. In both cases, delayed reactions are only those reported by donors. We try to make an exhaustive search of specific studies upon the real delayed reactions incidence so as to compare with our data. There were 1957 serious adverse reactions declared in our regional haemovigilance database between 2011 and 2015: 49 % occurring during donation, 40 % after it but before donor departure, and 11 % delayed events. There were 16,050 adverse reactions recorded during the first trimester of 2016 in mainland France, with 2.7 % delayed ones. Proportion of delayed events rises when gravity rises, until 27.6 % for the most serious ones. It varies between 2.2 % and 2.7 % for vasovagal reactions, haematomas, and other local reactions, and reaches 16.2 % for other general reactions. Data found in other studies with a spontaneous donor notification are of the same kind. But four studies soliciting specifically donor notification give a dramatically higher delayed reactions incidence, with an understatement greater than three out of four. Moreover, these studies found a majority of delayed reactions, which are not included in haemovigilance like fatigue or bruising. Occurrence of a delayed donor reaction is clearly underrated in standard haemovigilance. It

Impact of MAC Delay on AUV Localization: Underwater Localization Based on Hyperbolic Frequency Modulation Signal.

Science.gov (United States)

Kim, Sungryul; Yoo, Younghwan

2018-01-26

Medium Access Control (MAC) delay which occurs between the anchor node's transmissions is one of the error sources in underwater localization. In particular, in AUV localization, the MAC delay significantly degrades the ranging accuracy. The Cramer-Rao Low Bound (CRLB) definition theoretically proves that the MAC delay significantly degrades the localization performance. This paper proposes underwater localization combined with multiple access technology to decouple the localization performance from the MAC delay. Towards this goal, we adopt hyperbolic frequency modulation (HFM) signal that provides multiplexing based on its good property, high-temporal correlation. Owing to the multiplexing ability of the HFM signal, the anchor nodes can transmit packets without MAC delay, i.e., simultaneous transmission is possible. In addition, the simulation results show that the simultaneous transmission is not an optional communication scheme, but essential for the localization of mobile object in underwater.

Delay-range-dependent exponential H∞ synchronization of a class of delayed neural networks

International Nuclear Information System (INIS)

Karimi, Hamid Reza; Maass, Peter

2009-01-01

This article aims to present a multiple delayed state-feedback control design for exponential H ∞ synchronization problem of a class of delayed neural networks with multiple time-varying discrete delays. On the basis of the drive-response concept and by introducing a descriptor technique and using Lyapunov-Krasovskii functional, new delay-range-dependent sufficient conditions for exponential H ∞ synchronization of the drive-response structure of neural networks are driven in terms of linear matrix inequalities (LMIs). The explicit expression of the controller gain matrices are parameterized based on the solvability conditions such that the drive system and the response system can be exponentially synchronized. A numerical example is included to illustrate the applicability of the proposed design method.

New Results on Passivity Analysis of Stochastic Neural Networks with Time-Varying Delay and Leakage Delay

Directory of Open Access Journals (Sweden)

YaJun Li

2015-01-01

Full Text Available The passivity problem for a class of stochastic neural networks systems (SNNs with varying delay and leakage delay has been further studied in this paper. By constructing a more effective Lyapunov functional, employing the free-weighting matrix approach, and combining with integral inequality technic and stochastic analysis theory, the delay-dependent conditions have been proposed such that SNNs are asymptotically stable with guaranteed performance. The time-varying delay is divided into several subintervals and two adjustable parameters are introduced; more information about time delay is utilised and less conservative results have been obtained. Examples are provided to illustrate the less conservatism of the proposed method and simulations are given to show the impact of leakage delay on stability of SNNs.

The addition of locust bean gum but not water delayed the gastric emptying rate of a nutrient semisolid meal in healthy subjects

Directory of Open Access Journals (Sweden)

Björgell Ola

2003-06-01

Full Text Available Abstract Background Most of the previous studies regarding the effects of gel-forming fibres have considered the gastric emptying of liquid or solid meals after the addition of pectin or guar gum. The influence of locust bean gum, on gastric emptying of nutrient semisolid meals in humans has been less well studied, despite its common occurrence in foods. Using a standardised ultrasound method, this study was aimed at investigating if the gastric emptying in healthy subjects could be influenced by adding locust been gum, a widely used thickening agent, or water directly into a nutrient semisolid test meal. Methods The viscosity of a basic test meal (300 g rice pudding, 330 kcal was increased by adding Nestargel (6 g, 2.4 kcal, containing viscous dietary fibres (96.5% provided as seed flour of locust bean gum, and decreased by adding 100 ml of water. Gastric emptying of these three test meals were evaluated in fifteen healthy non-smoking volunteers, using ultrasound measurements of the gastric antral area to estimate the gastric emptying rate (GER. Results The median value of GER with the basic test meal (rice pudding was estimated at 63 %, (range 47 to 84 %, (the first quartile = 61 %, the third quartile = 69 %. Increasing the viscosity of the rice pudding by adding Nestargel, resulted in significantly lower gastric emptying rates (p p = 0.28 compared to the GER of the basic test meal. Conclusions We conclude that the addition of locust bean gum to a nutrient semisolid meal has a major impact on gastric emptying by delaying the emptying rate, but that the addition of water to this test meal has no influence on gastric emptying in healthy subjects.

Effect of Phase Response Curve Skew on Synchronization with and without Conduction Delays

Directory of Open Access Journals (Sweden)

Carmen eCanavier

2013-12-01

Full Text Available A central problem in cortical processing including sensory binding and attentional gating is how neurons can synchronize their responses with zero or near-zero time lag. For a spontaneously firing neuron, an input from another neuron can delay or advance the next spike by different amounts depending upon the timing of the input relative to the previous spike. This information constitutes the phase response curve (PRC. We present a simple graphical method for determining the effect of PRC shape on synchronization tendencies and illustrate it using type 1 PRCs, which consist entirely of advances (delays in response to excitation (inhibition. We obtained the following generic solutions for type 1 PRCs, which include the pulse coupled leaky integrate and fire model. For pairs with mutual excitation, exact synchrony can be stable for strong coupling because of the stabilizing effect of the causal limit region of the PRC in which an input triggers a spike immediately upon arrival. However, synchrony is unstable for short delays, because delayed inputs arrive during a refractory period and cannot trigger an immediate spike. Right skew destabilizes antiphase and enables modes with time lags that grow as the conduction delay is increased. Therefore, right skew favors near-synchrony at short conduction delays and a gradual transition between synchrony and antiphase for pairs coupled by mutual excitation. For pairs with mutual inhibition, zero time lag synchrony is stable for conduction delays ranging from zero to a substantial fraction of the period for pairs. However, for right skew there is a preferred antiphase mode at short delays. In contrast to mutual excitation, left skew destabilizes antiphase for mutual inhibition so that synchrony dominates at short delays as well. These pairwise synchronization tendencies constrain the synchronization properties of neurons embedded in larger networks.

Bifurcation analysis of delay-induced resonances of the El-Niño Southern Oscillation.

Science.gov (United States)

Krauskopf, Bernd; Sieber, Jan

2014-09-08

Models of global climate phenomena of low to intermediate complexity are very useful for providing an understanding at a conceptual level. An important aspect of such models is the presence of a number of feedback loops that feature considerable delay times, usually due to the time it takes to transport energy (for example, in the form of hot/cold air or water) around the globe. In this paper, we demonstrate how one can perform a bifurcation analysis of the behaviour of a periodically forced system with delay in dependence on key parameters. As an example, we consider the El-Niño Southern Oscillation (ENSO), which is a sea-surface temperature (SST) oscillation on a multi-year scale in the basin of the Pacific Ocean. One can think of ENSO as being generated by an interplay between two feedback effects, one positive and one negative, which act only after some delay that is determined by the speed of transport of SST anomalies across the Pacific. We perform here a case study of a simple delayed-feedback oscillator model for ENSO, which is parametrically forced by annual variation. More specifically, we use numerical bifurcation analysis tools to explore directly regions of delay-induced resonances and other stability boundaries in this delay-differential equation model for ENSO.

Earth system commitments due to delayed mitigation

International Nuclear Information System (INIS)

Pfister, Patrik L; Stocker, Thomas F

2016-01-01

As long as global CO 2 emissions continue to increase annually, long-term committed Earth system changes grow much faster than current observations. A novel metric linking this future growth to policy decisions today is the mitigation delay sensitivity (MDS), but MDS estimates for Earth system variables other than peak temperature (ΔT max ) are missing. Using an Earth System Model of Intermediate Complexity, we show that the current emission increase rate causes a ΔT max increase roughly 3–7.5 times as fast as observed warming, and a millenial steric sea level rise (SSLR) 7–25 times as fast as observed SSLR, depending on the achievable rate of emission reductions after the peak of emissions. These ranges are only slightly affected by the uncertainty range in equilibrium climate sensitivity, which is included in the above values. The extent of ocean acidification at the end of the century is also strongly dependent on the starting time and rate of emission reductions. The preservable surface ocean area with sufficient aragonite supersaturation for coral reef growth is diminished globally at an MDS of roughly 25%–80% per decade. A near-complete loss of this area becomes unavoidable if mitigation is delayed for a few years to decades. Also with respect to aragonite, 12%–18% of the Southern Ocean surface become undersaturated per decade, if emission reductions are delayed beyond 2015–2040. We conclude that the consequences of delaying global emission reductions are much better captured if the MDS of relevant Earth system variables is communicated in addition to current trends and total projected future changes. (letter)

Self-regulation strategies may enhance the acute effect of exercise on smoking delay.

Science.gov (United States)

Hatzigeorgiadis, Antonis; Pappa, Vassiliki; Tsiami, Anastasia; Tzatzaki, Theodora; Georgakouli, Kalliopi; Zourbanos, Nikos; Goudas, Marios; Chatzisarantis, Nikos; Theodorakis, Yannis

2016-06-01

The present study examined the acute effect of a moderate intensity aerobic exercise session combined with self-regulation on smoking delay in physically inactive smokers. Participants were 11 adults (5 males and 6 females) that completed three experimental conditions: control, exercise, and exercise using self-regulation strategies (SR). Following the experimental treatment smoking for the two exercise conditions delayed significantly more than for the control condition; in addition exercise SR delayed smoking marginally more that the plain exercise condition. Findings supported previous research that acute exercise reduces cravings to smoke, and suggests that the use of self-regulation strategies may strengthen exercise for smoking cessation interventions. Copyright © 2016 Elsevier Ltd. All rights reserved.

Generalized Projective Synchronization between Two Complex Networks with Time-Varying Coupling Delay

International Nuclear Information System (INIS)

Mei, Sun; Chang-Yan, Zeng; Li-Xin, Tian

2009-01-01

Generalized projective synchronization (GPS) between two complex networks with time-varying coupling delay is investigated. Based on the Lyapunov stability theory, a nonlinear controller and adaptive updated laws are designed. Feasibility of the proposed scheme is proven in theory. Moreover, two numerical examples are presented, using the energy resource system and Lü's system [Physica A 382 (2007) 672] as the nodes of the networks. GPS between two energy resource complex networks with time-varying coupling delay is achieved. This study can widen the application range of the generalized synchronization methods and will be instructive for the demand–supply of energy resource in some regions of China

Generalized Projective Synchronization between Two Complex Networks with Time-Varying Coupling Delay

Science.gov (United States)

Sun, Mei; Zeng, Chang-Yan; Tian, Li-Xin

2009-01-01

Generalized projective synchronization (GPS) between two complex networks with time-varying coupling delay is investigated. Based on the Lyapunov stability theory, a nonlinear controller and adaptive updated laws are designed. Feasibility of the proposed scheme is proven in theory. Moreover, two numerical examples are presented, using the energy resource system and Lü's system [Physica A 382 (2007) 672] as the nodes of the networks. GPS between two energy resource complex networks with time-varying coupling delay is achieved. This study can widen the application range of the generalized synchronization methods and will be instructive for the demand-supply of energy resource in some regions of China.

Risk factors for delayed healing at the free anterolateral thigh flap donor site

Directory of Open Access Journals (Sweden)

Yoshiro Abe

2018-01-01

Full Text Available Background The free anterolateral thigh (ALT flap has been widely used for various kinds of reconstructions. However, delayed healing at the donor site occasionally occurs due to wound dehiscence or the partial loss of grafted skin at the donor site. The aim of the present study was to identify reliable predictive factors for delayed healing at the donor site after the harvest of a free ALT flap. Methods This study included 52 patients who underwent reconstructive procedures using free ALT flaps. The delayed healing group included patients with wounds at the donor site that had not healed over 3 weeks after surgery, and the normal healing group included patients who showed wound healing within 3 weeks after surgery. Multivariate logistic regression models were created to identify the risk factors for delayed healing at the ALT flap donor site. Results Among the 52 patients, 24 (46.2% showed delayed healing at the donor site, and 6 patients required additional operative treatment. A high preoperative body mass index (BMI, smoking, and skin grafting were found to be significantly associated with delayed healing at the ALT donor site. Of the 37 patients who underwent skin grafting, 23 (62% experienced delayed healing at the donor site. Conclusions A high preoperative BMI, smoking, and skin grafting were risk factors for delayed healing at the free ALT donor site. Skin grafting at the ALT donor site should be avoided in patients with a high BMI or a habit of smoking.

Accelerating Smaller Cutbacks to Delay Larger Ones?

DEFF Research Database (Denmark)

Tepe, Markus; Vanhuysse, Pieter

2012-01-01

. Investigating both medium and large cutbacks in ageing welfare states, we test whether, in addition to conventional demographic and economic variables, political-institutional variables capturing partisanship (political ideology), electioneering (political cycle), and institutional constraints (political...... effects of unemployment and population aging: these socio-demographic variables tend to delay large-size cutbacks, but to accelerate medium-size cutbacks in pension generosity, possibly because they function as alarm bell signals urging policymakers to take still feasible incremental action through...

Enhanced Performance & Functionality of Tunable Delay Lines

Science.gov (United States)

2012-08-01

Based Tunable Optical Delays”, Optics Letters, Vol. 33, Issue 13, pp. 1518-1520 (2008). 2. Louis Christen, Irfan Fazal , Omer F. Yilmaz, Xiaoxia Wu...2008. 3. Omer F. Yilmaz, Louis Christen, Xiaoxia Wu, Scott R. Nuccio, Irfan Fazal , and Alan E. Willner, “Time-Slot-Interchange of 40 Gb/s Variable...F. Yilmaz, S. Khaleghi, L. Christen, I. Fazal , and A. E. Willner, “503 ns, Tunable Optical Delay of 40 Gb/s RZ-OOK using Additional λ-Conversion

Delay in the diagnosis of cancer

DEFF Research Database (Denmark)

Hansen, Rikke Pilegaard

for a detailed description of the patients' diagnostic pathways, allowing the researchers to draw the time line from symptom onset to treatment start, and to describe the characteristics of the patients and the GPs. Existing scales were used whenever possible; otherwise, ad hoc questions were constructed....... Chaper 1 introduces the concept of delay in the diagnosis of cancer. The chapter aims to provide insight into the time interval from symptom to treatment and into the patient and GP characteristics that potentially influence this interval. In addition, the chapter gives a brief overview of cancer...

Convergent dynamics for multistable delayed neural networks

International Nuclear Information System (INIS)

Shih, Chih-Wen; Tseng, Jui-Pin

2008-01-01

This investigation aims at developing a methodology to establish convergence of dynamics for delayed neural network systems with multiple stable equilibria. The present approach is general and can be applied to several network models. We take the Hopfield-type neural networks with both instantaneous and delayed feedbacks to illustrate the idea. We shall construct the complete dynamical scenario which comprises exactly 2 n stable equilibria and exactly (3 n − 2 n ) unstable equilibria for the n-neuron network. In addition, it is shown that every solution of the system converges to one of the equilibria as time tends to infinity. The approach is based on employing the geometrical structure of the network system. Positively invariant sets and componentwise dynamical properties are derived under the geometrical configuration. An iteration scheme is subsequently designed to confirm the convergence of dynamics for the system. Two examples with numerical simulations are arranged to illustrate the present theory

Delayed enhanced MRI in intraparenchymal tumors

International Nuclear Information System (INIS)

Eguchi, Takahiko; Morimoto, Tetsuya; Takeshima, Toshikazu

1991-01-01

Delayed enhanced MRI was performed on 20 intraparenchymal tumors, and these findings were compared with those of early enhanced MRI. Using the spin-echo technique (SE: 400-500/20 msec), early scans were obtained 5 minutes, and delayed scans were obtained 60 minutes, after the intravenous injection of 0.1 nmol of gadolinium-DTPA/Kg. We discussed the changes in the delayed scan with regard to the change in the pattern of enhancement and the boundary of enhancement. In these twenty intraparenchymal tumors, there were three low-grade astrocytomas, two anaplastic astrocytomas, seven glioblastomas, and eight metastatic tumors. The changes in the enhanced pattern showed three types as follows: Type I: heterogeneous enhancement in both early and delayed scans; Type II: heterogeneous enhancement in early scan and homogeneous enhancement in delayed scan; Type III: homogeneous enhancement in both early and delayed scans. Most malignant tumors, such as glioblastomas (6/8), anaplastic astrocytomas (2/2), and metastatic tumors (7/8), revealed Type I, although low-grade astrocytomas showed Type II (3/2) and Type III (1/3). The heterogeneous enhancement in delayed scan was found in malignant tumors and in low-grade astrocytoma; even if the early scan revealed heterogeneous enhancement, the delayed scan showed homogeneous enhancement. In the delayed scan, most enhanced boundaries spread out of the boundaries in the early scan. Glioblastomas spread markedly in the delayed scan, although none of the low-grade astrocytomas, anaplastic astrocytomas, or metastases revealed marked spreading. We called these marked increases in the delayed scan a 'spreading sign' and thought that this sign was specific to glioblastomas. Recently some authors have emphasized the usefulness of serial scans. Delayed enhanced MRI 60 minutes after the administration of a contrast medium was here found also to be useful for the accurate diagnosis for brain tumors. (author)

Project delay analysis of HRSG

Science.gov (United States)

Silvianita; Novega, A. S.; Rosyid, D. M.; Suntoyo

2017-08-01

Completion of HRSG (Heat Recovery Steam Generator) fabrication project sometimes is not sufficient with the targeted time written on the contract. The delay on fabrication process can cause some disadvantages for fabricator, including forfeit payment, delay on HRSG construction process up until HRSG trials delay. In this paper, the author is using semi quantitative on HRSG pressure part fabrication delay with configuration plant 1 GT (Gas Turbine) + 1 HRSG + 1 STG (Steam Turbine Generator) using bow-tie analysis method. Bow-tie analysis method is a combination from FTA (Fault tree analysis) and ETA (Event tree analysis) to develop the risk matrix of HRSG. The result from FTA analysis is use as a threat for preventive measure. The result from ETA analysis is use as impact from fabrication delay.

Robust outer synchronization between two nonlinear complex networks with parametric disturbances and mixed time-varying delays

Science.gov (United States)

Zhang, Chuan; Wang, Xingyuan; Luo, Chao; Li, Junqiu; Wang, Chunpeng

2018-03-01

In this paper, we focus on the robust outer synchronization problem between two nonlinear complex networks with parametric disturbances and mixed time-varying delays. Firstly, a general complex network model is proposed. Besides the nonlinear couplings, the network model in this paper can possess parametric disturbances, internal time-varying delay, discrete time-varying delay and distributed time-varying delay. Then, according to the robust control strategy, linear matrix inequality and Lyapunov stability theory, several outer synchronization protocols are strictly derived. Simple linear matrix controllers are designed to driver the response network synchronize to the drive network. Additionally, our results can be applied on the complex networks without parametric disturbances. Finally, by utilizing the delayed Lorenz chaotic system as the dynamics of all nodes, simulation examples are given to demonstrate the effectiveness of our theoretical results.

Nonlinear delay monopoly with bounded rationality

International Nuclear Information System (INIS)

Matsumoto, Akio; Szidarovszky, Ferenc

2012-01-01

The purpose of this paper is to study the dynamics of a monopolistic firm in a continuous-time framework. The firm is assumed to be boundedly rational and to experience time delays in obtaining and implementing information on output. The dynamic adjustment process is based on the gradient of the expected profit. The paper is divided into three parts: we examine delay effects on dynamics caused by one-time delay and two-time delays in the first two parts. Global dynamics and analytical results on local dynamics are numerically confirmed in the third part. Four main results are demonstrated. First, the stability switch from stability to instability occurs only once in the case of a single delay. Second, the alternation of stability and instability can continue if two time delays are involved. Third, the occurence of Hopf bifurcation is analytically shown if stability is lost. Finally, in a bifurcation process, there are a period-doubling cascade to chaos and a period-halving cascade to the equilibrium point in the case of two time delays if the difference between the two delays is large.

Monitoring delays in diagnosis of pulmonary tuberculosis in eight cities in Colombia

Directory of Open Access Journals (Sweden)

David A. Rodríguez

Full Text Available ABSTRACT Objective To measure time between onset of tuberculosis (TB symptoms and start of treatment, and to identify factors associated with delay in eight Colombian cities. Methods Operational research with a retrospective analytical cohort design was conducted in 2014 using routinely collected data about new smear-positive pulmonary TB patients from eight cities in Colombia (Barranquilla, Bogotá, Bucaramanga, Cali, Cúcuta, Medellín, Pereira, and Villavicencio. Date of symptom onset was sourced from TB surveillance databases. Data on all other variables came from National TB Program (NTP registers. Results There were 2 545 new cases of smear-positive pulmonary TB, but a plausible date of symptom onset was available for only 1 456 (57%. Median number of days between symptom onset and treatment start was 51 days (interquartile range: 27–101. A total of 72% of patients had a delay (> 30 days between symptom onset and treatment start, and 28% had a 3+ bacillary load at diagnosis. Based on multiple logistic regression, three factors were significantly associated with delay: being uninsured (odds ratio (OR: 1.30; 95% confidence interval (CI: 1.01–1.68 and having an unknown HIV status (OR: 1.81; CI: 1.04–3.17, which increased risk, and coming from a neighborhood with NTP-employed community health workers, which decreased risk (OR: 0.56; CI: 0.34–0.90. Conclusions Delays still prevent timely TB diagnosis and treatment in Colombia. As the country aims for TB elimination, delays must be reduced, especially in cities and vulnerable neighborhoods, to stop community transmission. The NTP should focus not only on the number of cases detected but also on how long it takes to detect them. To monitor interventions designed to reduce delays, additional dates in the process should be recorded routinely. In addition, reliability and completeness of data are crucial for monitoring.

Complex oscillatory behaviour in a delayed protein cross talk model with periodic forcing

International Nuclear Information System (INIS)

Nikolov, Svetoslav

2009-01-01

The purpose of this paper is to examine the effects of periodic forcing on the time delay protein cross talk model behaviour. We assume periodic variation for the plasma membrane permeability. The dynamic behaviour of the system is simulated and bifurcation diagrams are obtained for different parameters. The results show that periodic forcing can very easily give rise to complex dynamics, including a period-doubling cascade, chaos, quasi-periodic oscillating, and periodic windows. Finally, we calculate the maximal Lyapunov exponent in the regions of the parameter space where chaotic motion of delayed protein cross talk model with periodic forcing exists.

Memorized discrete systems and time-delay

CERN Document Server

Luo, Albert C J

2017-01-01

This book examines discrete dynamical systems with memory—nonlinear systems that exist extensively in biological organisms and financial and economic organizations, and time-delay systems that can be discretized into the memorized, discrete dynamical systems. It book further discusses stability and bifurcations of time-delay dynamical systems that can be investigated through memorized dynamical systems as well as bifurcations of memorized nonlinear dynamical systems, discretization methods of time-delay systems, and periodic motions to chaos in nonlinear time-delay systems. The book helps readers find analytical solutions of MDS, change traditional perturbation analysis in time-delay systems, detect motion complexity and singularity in MDS; and determine stability, bifurcation, and chaos in any time-delay system.

Delayed recall, hippocampal volume and Alzheimer neuropathology: findings from the Nun Study.

Science.gov (United States)

Mortimer, J A; Gosche, K M; Riley, K P; Markesbery, W R; Snowdon, D A

2004-02-10

To examine the associations of hippocampal volume and the severity of neurofibrillary lesions determined at autopsy with delayed verbal recall performance evaluated an average of 1 year prior to death. Hippocampal volumes were computed using postmortem brain MRI from the first 56 scanned participants of the Nun Study. Quantitative neuropathologic studies included lesion counts, Braak staging, and determination of whether neuropathologic criteria for Alzheimer disease (AD) were met. Multiple regression was used to assess the association of hippocampal volume and neuropathologic lesions with the number of words (out of 10) recalled on the Consortium to Establish a Registry for Alzheimer's Disease Delayed Word Recall Test administered an average of 1 year prior to death. When entered separately, hippocampal volume, Braak stage, and the mean neurofibrillary tangle counts in the CA-1 region of the hippocampus and the subiculum were strongly associated with the number of words recalled after a delay, adjusting for age and education. When hippocampal volume was entered together with each neuropathologic index, only hippocampal volume retained a significant association with the delayed recall measure. The association between hippocampal volume and the number of words recalled was present in both demented and nondemented individuals as well as in those with and without substantial AD neurofibrillary pathology. The association of neurofibrillary tangles with delayed verbal recall may reflect associated hippocampal atrophy.

Vernier Delay Unit

International Nuclear Information System (INIS)

Pierce, W.B.

1984-10-01

This module will accept differential ECL pulses from the auxiliary rear panel or NIM level pulses from the front panel. The pulses are produced at the output with a fixed delay that is software programmable in steps of 0.1 ns over the range of 0.1 to 10.5 ns. Multiple outputs are available at the front panel. Minimum delay through the module is 9 ns

Robustness Analysis of Hybrid Stochastic Neural Networks with Neutral Terms and Time-Varying Delays

Directory of Open Access Journals (Sweden)

Chunmei Wu

2015-01-01

Full Text Available We analyze the robustness of global exponential stability of hybrid stochastic neural networks subject to neutral terms and time-varying delays simultaneously. Given globally exponentially stable hybrid stochastic neural networks, we characterize the upper bounds of contraction coefficients of neutral terms and time-varying delays by using the transcendental equation. Moreover, we prove theoretically that, for any globally exponentially stable hybrid stochastic neural networks, if additive neutral terms and time-varying delays are smaller than the upper bounds arrived, then the perturbed neural networks are guaranteed to also be globally exponentially stable. Finally, a numerical simulation example is given to illustrate the presented criteria.

Factors associated with delay in trauma team activation and impact on patient outcomes.

Science.gov (United States)

Connolly, Rory; Woo, Michael Y; Lampron, Jacinthe; Perry, Jeffrey J

2017-09-05

Trauma code activation is initiated by emergency physicians using physiological and anatomical criteria, mechanism of injury, and patient demographic factors. Our objective was to identify factors associated with delayed trauma team activation. We assessed consecutive cases from a regional trauma database from January 2008 to March 2014. We defined a delay in trauma code activation as a time greater than 30 minutes from the time of arrival. We conducted univariate analysis for factors potentially influencing trauma team activation, and we subsequently used multiple logistic regression analysis models for delayed activation in relation to mortality, length of stay, and time to operative management. Patients totalling 846 were included for our analysis; 4.1% (35/846) of trauma codes were activated after 30 minutes. Mean age was 40.8 years in the early group versus 49.2 in the delayed group (p=0.01). Patients were over age 70 years in 7.6% in the early activation group versus 17.1% in the delayed group (p=0.04). There was no significant difference in sex, type of injury, injury severity, or time from injury between the two groups. There was no significant difference in mortality, median length of stay, or median time to operative management. Delayed activation is linked with increasing age with no clear link to increased mortality. Given the severe injuries in the delayed cohort that required activation of the trauma team, further emphasis on the older trauma patient and interventions to recognize this vulnerable population should be made.

Delayed entry into HIV care after diagnosis in two specialized care and treatment centres in Cameroon: the influence of CD4 count and WHO staging

Directory of Open Access Journals (Sweden)

Noah F. Takah

2016-07-01

Full Text Available Abstract Background Delayed entry into HIV care has complicated the challenges faced in sub-Saharan Africa due to the high HIV burden. A clear knowledge of the factors affecting delayed entry will be essential in directing interventions towards reducing delayed entry into HIV care. There exist very limited data on delayed entry in Cameroon despite its relevance; hence this study was conducted to determine the rate of delayed entry and its associated factors in HIV programmes in Cameroon. Methods Data used for this study was routine data obtained from the files of HIV patients who were diagnosed between January 1, 2015 and June 30, 2015 at Limbe and Buea regional hospital HIV centers in the South West region of Cameroon. Data analysis was done using SPSS version 20. Results Of the 223 patients included in the study, nearly one-quarter of patients (22.4 % delayed to enter HIV care within 3 months. Those who delayed to enter care were less likely to present at first diagnosis (using HIV rapid test with symptoms such as fever > 1 month (5 % versus 30 %, p = 0.01 and weight loss > 10 % (13 % versus 48 %, p < 0.001. Alcohol consumption, WHO stage and CD4 count levels were also associated with delayed entry in bivariate analysis. In multivariate analysis only CD4 count greater than 500cells/μl and WHO stages I and II were independently associated with delayed entry into HIV care within 3 months. Conclusion In the South West region of Cameroon, approximately 1 out of 4 patients delay to enter HIV care. This high proportion of patients who delay to enter care correlates to the findings recorded by other studies in sub Saharan Africa. Interventions tackling delayed entry into HIV care might need to be favorably directed towards patients that have high CD4 counts and are at very early WHO clinical stages.

Exponential synchronization of two nonlinearly non-delayed and delayed coupled complex dynamical networks

International Nuclear Information System (INIS)

Zheng Song

2012-01-01

In this paper, the exponential synchronization between two nonlinearly coupled complex networks with non-delayed and delayed coupling is investigated with Lyapunov-Krasovskii-type functionals. Based on the stability analysis of the impulsive differential equation and the linear matrix inequality, sufficient delay-dependent conditions for exponential synchronization are derived, and a linear impulsive controller and simple updated laws are also designed. Furthermore, the coupling matrices need not be symmetric or irreducible. Numerical examples are presented to verify the effectiveness and correctness of the synchronization criteria obtained.

Delay-Range-Dependent H∞ Control for Automatic Mooring Positioning System with Time-Varying Input Delay

Directory of Open Access Journals (Sweden)

Xiaoyu Su

2014-01-01

Full Text Available Aiming at the economy and security of the positioning system in semi-submersible platform, the paper presents a new scheme based on the mooring line switching strategy. Considering the input delay in switching process, H∞ control with time-varying input delay is designed to calculate the control forces to resist disturbing forces. In order to reduce the conservativeness, the information of the lower bound of delay is taken into account, and a Lyapunov function which contains the range of delay is constructed. Besides, the input constraint is considered to avoid breakage of mooring lines. The sufficient conditions for delay-range-dependent stabilization are derived in terms of LMI, and the controller is also obtained. The effectiveness of the proposed approach is illustrated by a realistic design example.

Systematic of delayed neutron parameters

International Nuclear Information System (INIS)

Isaev, S.G.; Piksaikin, V.M.

2000-01-01

The experimental studies of the energy dependence of the delayed neutron (DN) parameters for various fission systems has shown that the behaviour of a some combination of delayed neutron parameters has a similar features. On the basis of this findings the systematics of delayed neutron experimental data for thorium, uranium, plutonium and americium isotopes have been investigated with the purpose to find a correlation of DN parameters with characteristics of fissioning system as well as a correlation between the delayed neutron parameters themselves. It was presented the preliminary results which were obtained during study the physics interpretation of the results [ru

The transition between monostable and bistable states induced by time delay in intracellular calcium oscillation

International Nuclear Information System (INIS)

Duan, Wei-Long

2013-01-01

The revised role of the time delay of active processes with colored noises of transmission of intracellular Ca 2+ in intracellular calcium oscillation (ICO) is investigated by means of a first-order algorithm based on stochastic simulation. The simulation results indicate that time delay induces a double critical phenomenon and a transition between the monostable and bistable states of the ICO system. In addition, as the time delay increases, for a cytosolic Ca 2+ concentration with weak colored noises there appears a calcium burst, and the Ca 2+ concentration of the calcium store shows nonmonotonic variation. (paper)

Delay-Dependent Guaranteed Cost H∞ Control of an Interval System with Interval Time-Varying Delay

Directory of Open Access Journals (Sweden)

Zhongke Shi

2009-01-01

Full Text Available This paper concerns the problem of the delay-dependent robust stability and guaranteed cost H∞ control for an interval system with time-varying delay. The interval system with matrix factorization is provided and leads to less conservative conclusions than solving a square root. The time-varying delay is assumed to belong to an interval and the derivative of the interval time-varying delay is not a restriction, which allows a fast time-varying delay; also its applicability is broad. Based on the Lyapunov-Ktasovskii approach, a delay-dependent criterion for the existence of a state feedback controller, which guarantees the closed-loop system stability, the upper bound of cost function, and disturbance attenuation lever for all admissible uncertainties as well as out perturbation, is proposed in terms of linear matrix inequalities (LMIs. The criterion is derived by free weighting matrices that can reduce the conservatism. The effectiveness has been verified in a number example and the compute results are presented to validate the proposed design method.

Reconstruction of systems with impulses and delays from time series data

International Nuclear Information System (INIS)

Jeon, Jong-ha; Kim, Pilwon

2014-01-01

In this paper, we present an approach to identification of dynamical systems with irregular impulses and time delays. The suggested method enables one to reconstruct the underlying differential equations, using the l 1 -minimization technique in signal processing which takes advantage of the signal’s sparseness. Based on the idea that irregular impulses can be regarded as sparse error in the fitting procedure, we obtain an efficient algorithm for reconstructions that separates the regular parts of dynamics from impulsive ones. From time series data sampled from an impulsive ecological models, the suggested method restores an essential dynamics of the original systems. The method also applies to chaotic systems perturbed by intermittent impacts and successfully captures dynamics reflecting qualitative behavior independent of impacts. In addition, we can identify a time-delay Lotka–Volterra model with no prior information on delay time given, to which conventional parameter estimate methods are hardly applicable

Two planar polishing methods by using FIB technique: Toward ultimate top-down delayering for failure analysis

Energy Technology Data Exchange (ETDEWEB)

Wang, D. D., E-mail: dandan.wang@globalfoundries.com; Huang, Y. M.; Tan, P. K.; Feng, H.; Low, G. R.; Yap, H. H.; He, R.; Tan, H.; Dawood, M. K.; Zhao, Y. Z.; Lam, J.; Mai, Z. H. [GLOBALFOUNDRIES Singapore Pte. Ltd, 60 Woodlands Industrial Park D Street 2, Singapore 738406 (Singapore)

2015-12-15

Presently two major limiting factors are hindering the failure analysis (FA) development during the semiconductor manufacturing process and technology improvement: (1) Impossibility of manual polishing on the edge dies due to the amenability of layer peeling off; (2) Abundant demand of multi-locations FA, especially focusing different levels of layers simultaneously. Aiming at resolving these limitations, here we demonstrate two unique high precision polishing methods by using focused ion beam (FIB) technique. One is the vertical top down chemical etching at the aimed location; the other one is the planar top down slicing. Using the FIB for delayering not only solves these problems mentioned above, but also offers significant advantages over physical planar polishing methods such as: (1) having a better control of the delayering progress, (2) enabling precisely milling at a region of interest, (3) providing the prevention of over-delayering and (4) possessing capability to capture images at the region of interest simultaneously and cut into the die directly to expose the exact failure without damaging other sections of the specimen.

Stochastic two-delay differential model of delayed visual feedback effects on postural dynamics.

Science.gov (United States)

Boulet, Jason; Balasubramaniam, Ramesh; Daffertshofer, Andreas; Longtin, André

2010-01-28

We report on experiments and modelling involving the 'visuo-postural control loop' in the upright stance. We experimentally manipulated an artificial delay to the visual feedback during standing, presented at delays ranging from 0 to 1 s in increments of 250 ms. Using stochastic delay differential equations, we explicitly modelled the centre-of-pressure (COP) and centre-of-mass (COM) dynamics with two independent delay terms for vision and proprioception. A novel 'drifting fixed point' hypothesis was used to describe the fluctuations of the COM with the COP being modelled as a faster, corrective process of the COM. The model was in good agreement with the data in terms of probability density functions, power spectral densities, short- and long-term correlations (Hurst exponents) as well the critical time between the two ranges. This journal is © 2010 The Royal Society

About the distribution of delays in G.M counters

International Nuclear Information System (INIS)

Picard, E.; Rogozinski, A.

1954-01-01

We measure, with an oscillograph method the global time that pass between the time that a particle in a determined region of the studied counter and the answer of the amplifier associated to the counter. This delay is composed of the latency time T l and the T q delay, that result from the rise time finished of the impulse and whose value depends of the sensitivity threshold of the amplifier. The selection of (cosmic) particles generating discharge in the studied counter is obtained thanks to a telescope of two meters in coincidence whose opening is limited by a group of four counters in anti-coincidence with the first. The meter is arranged so that the median plan of the telescope crosses to a variable distance d of his axial thread. The measures have been done for different securities of the distance d and of the over-voltage V s applied to the counter. The results show that the statistical distribution of the delays is more spread especially when d is bigger and V s more reduced. The average values of the observed delays vary of 7.10 -8 s for d = 0 and V s es = 200 V, to 90.10 -8 s for d = 1,9 cm and V s = 50 V. The mobility of an free electron within the gaseous mixture filling the counter under a pressure of 10 cm.Hg was found equal: (2,1 ±0,2).10 4 cm 2 .s -1 .V -1 . (author) [fr

Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury

International Nuclear Information System (INIS)

Li, Yonggang; Lein, Pamela J.; Liu, Cuimei; Bruun, Donald A.; Giulivi, Cecilia; Ford, Gregory D.; Tewolde, Teclemichael; Ross-Inta, Catherine; Ford, Byron D.

2012-01-01

Current medical countermeasures against organophosphate (OP) nerve agents are effective in reducing mortality, but do not sufficiently protect the CNS from delayed brain damage and persistent neurological symptoms. In this study, we examined the efficacy of neuregulin-1 (NRG-1) in protecting against delayed neuronal cell death following acute intoxication with the OP diisopropylflurophosphate (DFP). Adult male Sprague–Dawley rats were pretreated with pyridostigmine (0.1 mg/kg BW, i.m.) and atropine methylnitrate (20 mg/kg BW, i.m.) prior to DFP (9 mg/kg BW, i.p.) intoxication to increase survival and reduce peripheral signs of cholinergic toxicity but not prevent DFP-induced seizures or delayed neuronal injury. Pretreatment with NRG-1 did not protect against seizures in rats exposed to DFP. However, neuronal injury was significantly reduced in most brain regions by pretreatment with NRG-1 isoforms NRG-EGF (3.2 μg/kg BW, i.a) or NRG-GGF2 (48 μg/kg BW, i.a.) as determined by FluroJade-B labeling in multiple brain regions at 24 h post-DFP injection. NRG-1 also blocked apoptosis and oxidative stress-mediated protein damage in the brains of DFP-intoxicated rats. Administration of NRG-1 at 1 h after DFP injection similarly provided significant neuroprotection against delayed neuronal injury. These findings identify NRG-1 as a promising adjuvant therapy to current medical countermeasures for enhancing neuroprotection against acute OP intoxication. -- Highlights: ► NRG-1 blocked DFP induced neuronal injury. ► NRG-1 did not protect against seizures in rats exposed to DFP. ► NRG-1 blocked apoptosis and oxidative stress in the brains of DFP-intoxicated rats. ► Administration of NRG-1 at 1 h after DFP injection prevented delayed neuronal injury.

Analysis of a first-order delay differential-delay equation containing two delays

Science.gov (United States)

Marriott, C.; Vallée, R.; Delisle, C.

1989-09-01

An experimental and numerical analysis of the behavior of a two-delay differential equation is presented. It is shown that much of the system's behavior can be related to the stability behavior of the underlying linearized modes. A new phenomenon, mode crossing, is explored.

Delaying gratification depends on social trust

Science.gov (United States)

Michaelson, Laura; de la Vega, Alejandro; Chatham, Christopher H.; Munakata, Yuko

2013-01-01

Delaying gratification is hard, yet predictive of important life outcomes, such as academic achievement and physical health. Prominent theories focus on the role of self-control, hypersensitivity to immediate rewards, and the cost of time spent waiting. However, delaying gratification may also require trust in people delivering future rewards as promised. To test the role of social trust, participants were presented with character vignettes and faces that varied in trustworthiness, and then choose between hypothetical smaller immediate or larger delayed rewards from those characters. Across two experiments, participants were less willing to wait for delayed rewards from less trustworthy characters, and perceived trustworthiness predicted willingness to delay gratification. These findings provide the first demonstration of a causal role for social trust in willingness to delay gratification, independent of other relevant factors, such as self-control or reward history. Thus, delaying gratification requires choosing not only a later reward, but a reward that is potentially less likely to be delivered, when there is doubt about the person promising it. Implications of this work include the need to revise prominent theories of delay of gratification, and new directions for interventions with populations characterized by impulsivity. PMID:23801977

Delaying gratification depends on social trust

Directory of Open Access Journals (Sweden)

Laura eMichaelson

2013-06-01

Full Text Available Delaying gratification is hard, yet predictive of important life outcomes, such as academic achievement and physical health. Prominent theories focus on the role of self-control, hypersensitivity to immediate rewards, and the cost of time spent waiting. However, delaying gratification may also require trust in people delivering future rewards as promised. To test the role of social trust, participants were presented with character vignettes and faces that varied in trustworthiness, and then chose between hypothetical smaller immediate or larger delayed rewards from those characters. Across two experiments, participants were less willing to wait for delayed rewards from less trustworthy characters, and perceived trustworthiness predicted willingness to delay gratification. These findings provide the first demonstration of a causal role for social trust in willingness to delay gratification, independent of other relevant factors, such as self-control or reward history. Thus, delaying gratification requires choosing not only a later reward, but a reward that is potentially less likely to be delivered, when there is doubt about the person promising it. Implications of this work include the need to revise prominent theories of delay of gratification, and new directions for interventions with populations characterized by impulsivity.

Global impulsive exponential synchronization of stochastic perturbed chaotic delayed neural networks

International Nuclear Information System (INIS)

Hua-Guang, Zhang; Tie-Dong, Ma; Jie, Fu; Shao-Cheng, Tong

2009-01-01

In this paper, the global impulsive exponential synchronization problem of a class of chaotic delayed neural networks (DNNs) with stochastic perturbation is studied. Based on the Lyapunov stability theory, stochastic analysis approach and an efficient impulsive delay differential inequality, some new exponential synchronization criteria expressed in the form of the linear matrix inequality (LMI) are derived. The designed impulsive controller not only can globally exponentially stabilize the error dynamics in mean square, but also can control the exponential synchronization rate. Furthermore, to estimate the stable region of the synchronization error dynamics, a novel optimization control algorithm is proposed, which can deal with the minimum problem with two nonlinear terms coexisting in LMIs effectively. Simulation results finally demonstrate the effectiveness of the proposed method

Boarding is associated with higher rates of medication delays and adverse events but fewer laboratory-related delays.

Science.gov (United States)

Sri-On, Jiraporn; Chang, Yuchiao; Curley, David P; Camargo, Carlos A; Weissman, Joel S; Singer, Sara J; Liu, Shan W

2014-09-01

Hospital crowding and emergency department (ED) boarding are large and growing problems. To date, there has been a paucity of information regarding the quality of care received by patients boarding in the ED compared with the care received by patients on an inpatient unit. We compared the rate of delays and adverse events at the event level that occur while boarding in the ED vs while on an inpatient unit. This study was a secondary analysis of data from medical record review and administrative databases at 2 urban academic teaching hospitals from August 1, 2004, through January 31, 2005. We measured delayed repeat cardiac enzymes, delayed partial thromboplastin time level checks, delayed antibiotic administration, delayed administration of home medications, and adverse events. We compared the incidence of events during ED boarding vs while on an inpatient unit. Among 1431 patient medical records, we identified 1016 events. Emergency department boarding was associated with an increased risk of home medication delays (risk ratio [RR], 1.54; 95% confidence interval [CI], 1.26-1.88), delayed antibiotic administration (RR, 2.49; 95% CI, 1.72-3.52), and adverse events (RR, 2.36; 95% CI, 1.15-4.72). On the contrary, ED boarding was associated with fewer delays in repeat cardiac enzymes (RR, 0.17; 95% CI, 0.09-0.27) and delayed partial thromboplastin time checks (RR, 0.54; 95% CI, 0.27-0.96). Compared with inpatient units, ED boarding was associated with more medication-related delays and adverse events but fewer laboratory-related delays. Until we can eliminate ED boarding, it is critical to identify areas for improvement. Copyright © 2014 Elsevier Inc. All rights reserved.

Global exponential convergence of neutral-type Hopfield neural networks with multi-proportional delays and leakage delays

International Nuclear Information System (INIS)

Xu, Changjin; Li, Peiluan

2017-01-01

This paper is concerned with a class of neutral-type Hopfield neural networks with multi-proportional delays and leakage delays. Using the differential inequality theory, a set of sufficient conditions which guarantee that all solutions of neutral-type Hopfield neural networks with multi-proportional delays and leakage delays converge exponentially to zero vector are derived. Computer simulations are carried out to verify our theoretical findings. The obtained results of this paper are new and complement some previous studies.

Delay-Dependent Exponential Stability for Discrete-Time BAM Neural Networks with Time-Varying Delays

Directory of Open Access Journals (Sweden)

Yonggang Chen

2008-01-01

Full Text Available This paper considers the delay-dependent exponential stability for discrete-time BAM neural networks with time-varying delays. By constructing the new Lyapunov functional, the improved delay-dependent exponential stability criterion is derived in terms of linear matrix inequality (LMI. Moreover, in order to reduce the conservativeness, some slack matrices are introduced in this paper. Two numerical examples are presented to show the effectiveness and less conservativeness of the proposed method.

Environmental enrichment decreases asphyxia-induced neurobehavioral developmental delay in neonatal rats.

Science.gov (United States)

Kiss, Peter; Vadasz, Gyongyver; Kiss-Illes, Blanka; Horvath, Gabor; Tamas, Andrea; Reglodi, Dora; Koppan, Miklos

2013-11-13

Perinatal asphyxia during delivery produces long-term disability and represents a major problem in neonatal and pediatric care. Numerous neuroprotective approaches have been described to decrease the effects of perinatal asphyxia. Enriched environment is a popular strategy to counteract nervous system injuries. The aim of the present study was to investigate whether enriched environment is able to decrease the asphyxia-induced neurobehavioral developmental delay in neonatal rats. Asphyxia was induced in ready-to-deliver mothers by removing the pups by caesarian section after 15 min of asphyxia. Somatic and neurobehavioral development was tested daily and motor coordination weekly. Our results show that rats undergoing perinatal asphyxia had a marked developmental delay and worse performance in motor coordination tests. However, pups kept in enriched environment showed a decrease in the developmental delay observed in control asphyctic pups. Rats growing up in enriched environment did not show decrease in weight gain after the first week and the delay in reflex appearance was not as marked as in control rats. In addition, the development of motor coordination was not as strikingly delayed as in the control group. Short-term neurofunctional outcome are known to correlate with long-term deficits. Our results thus show that enriched environment could be a powerful strategy to decrease the deleterious developmental effects of perinatal asphyxia.

Stability and oscillation of two coupled Duffing equations with time delay state feedback

International Nuclear Information System (INIS)

El-Bassiouny, A F

2006-01-01

This paper presents an analytical study of the simultaneous principal parametric resonances of two coupled Duffing equations with time delay state feedback. The concept of an equivalent damping related to the delay feedback is proposed and the appropriate choice of the feedback gains and the time delay is discussed from the viewpoint of vibration control. The method of multiple scales is used to determine a set of ordinary differential equations governing the modulation of the amplitudes and phases of the two modes. The first order approximation of the resonances are derived and the effect of time delay on the resonances is investigated. The fixed points correspond to a periodic motion for the starting system and we show the frequency-response curves. We analyse the effect of time delay and the other different parameters on these oscillations. The stability of the fixed points is examined by using the variational method. Numerical solutions are carried out and graphical representations of the results are presented and discussed. Increasing in the time delay τ given decreasing and increasing in the regions of definition and stability respectively and the first mode has decreased magnitudes. The multivalued solutions disappear when decreasing the coefficients of cubic nonlinearities of the second mode α 3 and the detuning parameter σ 2 respectively. Both modes shift to the left for increasing linear feedback gain v 1 and the coefficient of parametric excitation f 1 respectively

Stability switches, oscillatory multistability, and spatio-temporal patterns of nonlinear oscillations in recurrently delay coupled neural networks.

Science.gov (United States)

Song, Yongli; Makarov, Valeri A; Velarde, Manuel G

2009-08-01

A model of time-delay recurrently coupled spatially segregated neural assemblies is here proposed. We show that it operates like some of the hierarchical architectures of the brain. Each assembly is a neural network with no delay in the local couplings between the units. The delay appears in the long range feedforward and feedback inter-assemblies communications. Bifurcation analysis of a simple four-units system in the autonomous case shows the richness of the dynamical behaviors in a biophysically plausible parameter region. We find oscillatory multistability, hysteresis, and stability switches of the rest state provoked by the time delay. Then we investigate the spatio-temporal patterns of bifurcating periodic solutions by using the symmetric local Hopf bifurcation theory of delay differential equations and derive the equation describing the flow on the center manifold that enables us determining the direction of Hopf bifurcations and stability of the bifurcating periodic orbits. We also discuss computational properties of the system due to the delay when an external drive of the network mimicks external sensory input.

The impact of cognitive load on delayed recall.

Science.gov (United States)

Camos, Valérie; Portrat, Sophie

2015-08-01

Recent studies have suggested that long-term retention of items studied in a working memory span task depends on the refreshing of memory items-more specifically, on the number of refreshing opportunities. However, it was previously shown that refreshing depends on the cognitive load of the concurrent task introduced in the working memory span task. Thus, cognitive load should determine the long-term retention of items assessed in a delayed-recall test if such retention relies on refreshing. In two experiments, while the amount of refreshing opportunities remained constant, we varied the cognitive load of the concurrent task by either introducing tasks differing in their attentional demands or varying the pace of the concurrent task. To verify that this effect was related to refreshing and not to any maintenance mechanism, we also manipulated the availability of subvocal rehearsal. Replicating previous results, increasing cognitive load reduced immediate recall. This increase also had a detrimental effect on delayed recall. Conversely, the addition of concurrent articulation reduced immediate but not delayed recall. This study shows that both working and episodic memory traces depend on the cognitive load of the concurrent task, whereas the use of rehearsal affects only working memory performance. These findings add further evidence of the dissociation between subvocal rehearsal and attentional refreshing.

Micromachined silicon acoustic delay line with 3D-printed micro linkers and tapered input for improved structural stability and acoustic directivity

International Nuclear Information System (INIS)

Cho, Y; Kumar, A; Xu, S; Zou, J

2016-01-01

Recent studies have shown that micromachined silicon acoustic delay lines can provide a promising solution to achieve real-time photoacoustic tomography without the need for complex transducer arrays and data acquisition electronics. To achieve deeper imaging depth and wider field of view, a longer delay time and therefore delay length are required. However, as the length of the delay line increases, it becomes more vulnerable to structural instability due to reduced mechanical stiffness. In this paper, we report the design, fabrication, and testing of a new silicon acoustic delay line enhanced with 3D printed polymer micro linker structures. First, mechanical deformation of the silicon acoustic delay line (with and without linker structures) under gravity was simulated by using finite element method. Second, the acoustic crosstalk and acoustic attenuation caused by the polymer micro linker structures were evaluated with both numerical simulation and ultrasound transmission testing. The result shows that the use of the polymer micro linker structures significantly improves the structural stability of the silicon acoustic delay lines without creating additional acoustic attenuation and crosstalk. In addition, the improvement of the acoustic acceptance angle of the silicon acoustic delay lines was also investigated to better suppress the reception of unwanted ultrasound signals outside of the imaging plane. These two improvements are expected to provide an effective solution to eliminate current limitations on the achievable acoustic delay time and out-of-plane imaging resolution of micromachined silicon acoustic delay line arrays. (paper)

Diagnostics of septic arthritis in the sternoclavicular region

DEFF Research Database (Denmark)

Bodker, Tina; Tottrup, Mikkel; Petersen, Klaus Kjaer

2013-01-01

diagnosed with septic arthritis whereas CT in five patients led to the diagnosis in only one. Three were subsequently diagnosed by MRI, but delayed more than 2.5 weeks, and one was diagnosed by surgery. The median time to diagnosis was 1.5 weeks. The delay caused by imaging was 0 days to 11.5 weeks (median...... 0 days). By re-evaluation overlooked complications included mediastinitis in seven patients (three diffuse, four localized), and abscesses and pleuritis each in four patients. Conclusion: Awareness of infection in the SC region is important to avoid diagnostic delay. MRI is proposed as the initial...

Multistability of memristive Cohen-Grossberg neural networks with non-monotonic piecewise linear activation functions and time-varying delays.

Science.gov (United States)

Nie, Xiaobing; Zheng, Wei Xing; Cao, Jinde

2015-11-01

The problem of coexistence and dynamical behaviors of multiple equilibrium points is addressed for a class of memristive Cohen-Grossberg neural networks with non-monotonic piecewise linear activation functions and time-varying delays. By virtue of the fixed point theorem, nonsmooth analysis theory and other analytical tools, some sufficient conditions are established to guarantee that such n-dimensional memristive Cohen-Grossberg neural networks can have 5(n) equilibrium points, among which 3(n) equilibrium points are locally exponentially stable. It is shown that greater storage capacity can be achieved by neural networks with the non-monotonic activation functions introduced herein than the ones with Mexican-hat-type activation function. In addition, unlike most existing multistability results of neural networks with monotonic activation functions, those obtained 3(n) locally stable equilibrium points are located both in saturated regions and unsaturated regions. The theoretical findings are verified by an illustrative example with computer simulations. Copyright © 2015 Elsevier Ltd. All rights reserved.

The Effects of Test Trial and Processing Level on Immediate and Delayed Retention

Science.gov (United States)

Chang, Sau Hou

2017-01-01

The purpose of the present study was to investigate the effects of test trial and processing level on immediate and delayed retention. A 2 × 2 × 2 mixed ANOVAs was used with two between-subject factors of test trial (single test, repeated test) and processing level (shallow, deep), and one within-subject factor of final recall (immediate, delayed). Seventy-six college students were randomly assigned first to the single test (studied the stimulus words three times and took one free-recall test) and the repeated test trials (studied the stimulus words once and took three consecutive free-recall tests), and then to the shallow processing level (asked whether each stimulus word was presented in capital letter or in small letter) and the deep processing level (whether each stimulus word belonged to a particular category) to study forty stimulus words. The immediate test was administered five minutes after the trials, whereas the delayed test was administered one week later. Results showed that single test trial recalled more words than repeated test trial in immediate final free-recall test, participants in deep processing performed better than those in shallow processing in both immediate and delayed retention. However, the dominance of single test trial and deep processing did not happen in delayed retention. Additional study trials did not further enhance the delayed retention of words encoded in deep processing, but did enhance the delayed retention of words encoded in shallow processing. PMID:28344679

The Effects of Test Trial and Processing Level on Immediate and Delayed Retention.

Science.gov (United States)

Chang, Sau Hou

2017-03-01

The purpose of the present study was to investigate the effects of test trial and processing level on immediate and delayed retention. A 2 × 2 × 2 mixed ANOVAs was used with two between-subject factors of test trial (single test, repeated test) and processing level (shallow, deep), and one within-subject factor of final recall (immediate, delayed). Seventy-six college students were randomly assigned first to the single test (studied the stimulus words three times and took one free-recall test) and the repeated test trials (studied the stimulus words once and took three consecutive free-recall tests), and then to the shallow processing level (asked whether each stimulus word was presented in capital letter or in small letter) and the deep processing level (whether each stimulus word belonged to a particular category) to study forty stimulus words. The immediate test was administered five minutes after the trials, whereas the delayed test was administered one week later. Results showed that single test trial recalled more words than repeated test trial in immediate final free-recall test, participants in deep processing performed better than those in shallow processing in both immediate and delayed retention. However, the dominance of single test trial and deep processing did not happen in delayed retention. Additional study trials did not further enhance the delayed retention of words encoded in deep processing, but did enhance the delayed retention of words encoded in shallow processing.

The Effects of Test Trial and Processing Level on Immediate and Delayed Retention

Directory of Open Access Journals (Sweden)

Sau Hou Chang

2017-03-01

Full Text Available The purpose of the present study was to investigate the effects of test trial and processing level on immediate and delayed retention. A 2 × 2 × 2 mixed ANOVAs was used with two between-subject factors of test trial (single test, repeated test and processing level (shallow, deep, and one within-subject factor of final recall (immediate, delayed. Seventy-six college students were randomly assigned first to the single test (studied the stimulus words three times and took one free-recall test and the repeated test trials (studied the stimulus words once and took three consecutive free-recall tests, and then to the shallow processing level (asked whether each stimulus word was presented in capital letter or in small letter and the deep processing level (whether each stimulus word belonged to a particular category to study forty stimulus words. The immediate test was administered five minutes after the trials, whereas the delayed test was administered one week later. Results showed that single test trial recalled more words than repeated test trial in immediate final free-recall test, participants in deep processing performed better than those in shallow processing in both immediate and delayed retention. However, the dominance of single test trial and deep processing did not happen in delayed retention. Additional study trials did not further enhance the delayed retention of words encoded in deep processing, but did enhance the delayed retention of words encoded in shallow processing.

Group Delay of High Q Antennas

DEFF Research Database (Denmark)

Bahramzy, Pevand; Pedersen, Gert Frølund

2013-01-01

Group Delay variations versus frequency is an essential factor which can cause distortion and degradation in the signals. Usually this is an issue in wideband communication systems, such as satellite communication systems, which are used for transmitting wideband data. However, group delay can also...... become an issue, when working with high Q antennas, because of the steep phase shift over the frequency. In this paper, it is measured how large group delay variations can become, when going from a low Q antenna to a high Q antenna. The group delay of a low Q antenna is shown to be around 1.3 ns, whereas...... a high Q antenna has group delay of around 22 ns. It is due to this huge group delay variation characteristics of high Q antennas, that signal distortion might occur in the radio system with high Q antennas....

Delay-dependent asymptotic stability of mobile ad-hoc networks: A descriptor system approach

International Nuclear Information System (INIS)

Yang Juan; Yang Dan; Zhang Xiao-Hong; Huang Bin; Luo Jian-Lu

2014-01-01

In order to analyze the capacity stability of the time-varying-propagation and delay-dependent of mobile ad-hoc networks (MANETs), in this paper, a novel approach is proposed to explore the capacity asymptotic stability for the delay-dependent of MANETs based on non-cooperative game theory, where the delay-dependent conditions are explicitly taken into consideration. This approach is based on the Lyapunov—Krasovskii stability theory for functional differential equations and the linear matrix inequality (LMI) technique. A corresponding Lyapunov—Krasovskii functional is introduced for the stability analysis of this system with use of the descriptor and “neutral-type” model transformation without producing any additional dynamics. The delay-dependent stability criteria are derived for this system. Conditions are given in terms of linear matrix inequalities, and for the first time referred to neutral systems with the time-varying propagation and delay-dependent stability for capacity analysis of MANETs. The proposed criteria are less conservative since they are based on an equivalent model transformation. Furthermore, we also provide an effective and efficient iterative algorithm to solve the constrained stability control model. Simulation experiments have verified the effectiveness and efficiency of our algorithm. (general)

Globally exponential stability and periodic solutions of CNNS with variable coefficients and variable delays

International Nuclear Information System (INIS)

Liu Haifei; Wang Li

2006-01-01

In this Letter, by using the inequality method and the Lyapunov functional method, we analyze the globally exponential stability and the existence of periodic solutions of a class of cellular neutral networks with delays and variable coefficients. Some simple and new sufficient conditions ensuring the existence and uniqueness of globally exponential stability of periodic solutions for cellular neutral networks with variable coefficients and delays are obtained. In addition, one example is also worked out to illustrate our theory

When the Battle is Lost and Won: Delayed Chest Closure After Bilateral Lung Transplantation.

Science.gov (United States)

Soresi, Simona; Sabashnikov, Anton; Weymann, Alexander; Zeriouh, Mohamed; Simon, André R; Popov, Aron-Frederik

2015-10-12

In this article we summarize benefits of delayed chest closure strategy in lung transplantation, addressing indications, different surgical techniques, and additional perioperative treatment. Delayed chest closure seems to be a valuable and safe strategy in managing patients with various conditions after lung transplantation, such as instable hemodynamics, need for high respiratory pressures, coagulopathy, and size mismatch. Therefore, this approach should be considered in lung transplant centers to give patients time to recover before the chest is closed.

Globally exponential stability and periodic solutions of CNNS with variable coefficients and variable delays

Energy Technology Data Exchange (ETDEWEB)

Liu Haifei [School of Management and Engineering, Nanjing University, Nanjing 210093 (China)]. E-mail: hfliu80@126.com; Wang Li [School of Management and Engineering, Nanjing University, Nanjing 210093 (China)

2006-09-15

In this Letter, by using the inequality method and the Lyapunov functional method, we analyze the globally exponential stability and the existence of periodic solutions of a class of cellular neutral networks with delays and variable coefficients. Some simple and new sufficient conditions ensuring the existence and uniqueness of globally exponential stability of periodic solutions for cellular neutral networks with variable coefficients and delays are obtained. In addition, one example is also worked out to illustrate our theory.

An In-Pile Kinetic Method for Determining the Delayed Neutron Fraction βeff

International Nuclear Information System (INIS)

Gilad, E.; Rivin, O.; Ettedgui, H.; Yaar, I.; Geslot, B.; Pepino, A.; Di Salvo, J.; Gruel, A.; Blaise, P.

2014-01-01

Delayed neutrons are of fundamental importance in the field of nuclear reactor dynamics and control. Although only a small fraction of the neutrons emitted by fission are not prompt, the knowledge of the delayed neutrons parameters is essential for transient analysis, such as startup or shutdown of the reactor, as well as for accidents analysis and control system design [1]. One of the main delayed neutron parameters used in the point reactor model equations is the effective delayed neutron fraction, which incorporates both delayed neutron spectral properties and core geometrical configuration [1,2]. Additional delayed neutron parameters include the fraction of fission neutrons emitted in each delayed group, and the delayed neutron precursors decay constants . Experimental efforts aimed at determining the value ofβ, which provide experimental support for the evaluation of delayed neutron parameters, are extremely valuable. This is due to the fact that unlike other fields in reactor physics, e.g. criticality safety or shielding, the availability of experimental data and benchmark problems for validating delayed neutron parameters and its implementation in different models is highly limited. Furthermore, the existing experimental data exhibit significant discrepancies between the different sets of parameter, which lead to substantial disparity in the analysis of kinetic experiments and reactor dynamic behavior]. In this work, a method for determining the effective delayed neutron fraction using in-pile reactivity oscillation and Fourier analysis is presented. The method is based on measurements of the reactor's power response to small periodic in-pile reactivity perturbations and utilizes Fourier analysis for reconstruction of the reactor zero power transfer function. Knowledge of the reactor transfer function enables the estimation of theβ value using multi-parameter nonlinear fit. The method accounts for higher harmonics, which are excited by the trapezoidal

Parenting Practices and Associations with Development Delays among Young Children in Dominican Republic.

Science.gov (United States)

Uwemedimo, Omolara Thomas; Howlader, Afrin; Pierret, Giselina

According to the World Health Organization, >200 million children in low- and middle-income countries experience developmental delays. However, household structure and parenting practices have been minimally explored as potential correlates of developmental delay in low- and middle-income countries, despite potential as areas for intervention. The objective of the study was to examine associations of developmental delays with use of World Health Organization-recommended parenting practices among a clinic-based cohort of children aged 6-60 months attending in La Romana, Dominican Republic. This study was conducted among 74 caregiver-child pairs attending the growth-monitoring clinic at Hospital Francisco Gonzalvo in June 2015. The Malawi Developmental Assessment Tool was adapted and performed on each child to assess socioadaptive, fine motor, gross motor, and language development. The IMCI Household Level Survey Questionnaire was used to assess parenting practices. Fisher's exact test was used to determine associations significant at P children had a delay in at least 1 developmental domain. Most caregivers used scolding (43.2%) or spanking (44%) for child discipline. Children who were disciplined by spanking and scolding were more likely to have language delay (P = .007) and socioadaptive delay (P = .077), respectively. On regression analysis, children with younger primary caregivers had 7 times higher odds of language delay (adjusted odds ratio [AOR]: 7.35, 95% confidence interval [CI]: 1.52-35.61) and 4 times greater odds of any delay (AOR: 4.72, 95% CI: 1.01-22.22). In addition, children punished by spanking had 5 times higher odds of having language delay (AOR: 5.04, 95% CI: 1.13-22.39). Parenting practices such as harsh punishment and lack of positive parental reinforcement were found to have strong associations with language and socioadaptive delays. Likewise, delays were also more common among children with younger caregivers. Copyright © 2017 Icahn

Direct/Delayed Response Project: Soil-characterization comparison

International Nuclear Information System (INIS)

Fenstermaker, L.K.; Byers, G.E.; Starks, T.H.; Miah, M.J.; Palmer, C.J.

1992-01-01

A large amount of soil characterization data has been collected as a component of the Direct/Delayed Response Project (DDRP) in the acid rain Aquatic Effects Research Program. An interlaboratory comparison study was undertaken to identify the comparability of the data to that obtained from representative soil characterization laboratories. Participating laboratories were selected at random from four regions of the U.S. and two regions of Canada. Two original DDRP contract laboratories also participated. Duplicate samples of six soil audit materials and two liquid soil extracts were sent to each of the laboratories in two separate batches. Laboratories used their own protocols to perform the analyses requested except for the contract laboratories which followed the DDRP protocol. Liquid audits were used in an effort to identify if interlaboratory differences were due to extraction procedures or chemical measurements. A component of the variability in the results was attributed to differences in the methods used such as soil/solution ratios, extractants or extraction procedures. The largest number of different methods used was for the measurement of cation exchange capacity. The results between the DDRP soil survey data and the study's results were compared using Youden-pair plots. In addition, standard statistical tests were performed. Overall, the DDRP data were comparable to the data from the study. However, out of the total 141 comparisons involving results from six or more laboratories, the results from the two contract laboratories did not meet the comparison criteria in 19 cases. Since there was never a case in which both contract laboratories failed, it would appear that the 19 cases which were not comparable were due to random analytical errors, incorrectly reported results, or misapplication of DDRP protocol

Linear rotary optical delay lines

Science.gov (United States)

Guerboukha, Hichem; Qu, Hang; Skorobogatiy, Maksim

2016-03-01

We present a semi-analytical solution for the design of a high-speed rotary optical delay line that use a combination of two rotating curvilinear reflectors. We demonstrate that it is possible to design an infinite variety of the optical delay lines featuring linear dependence of the optical delay on the rotation angle. This is achieved via shape optimization of the rotating reflector surfaces. Moreover, a convenient spatial separation of the incoming and outgoing beams is possible. For the sake of example, we present blades that fit into a circle of 10cm diameter. Finally, a prototype of a rotary delay line is fabricated using CNC machining, and its optical properties are characterized.

Synchronization of nonidentical chaotic neural networks with leakage delay and mixed time-varying delays

Directory of Open Access Journals (Sweden)

Cao Jinde

2011-01-01

Full Text Available Abstract In this paper, an integral sliding mode control approach is presented to investigate synchronization of nonidentical chaotic neural networks with discrete and distributed time-varying delays as well as leakage delay. By considering a proper sliding surface and constructing Lyapunov-Krasovskii functional, as well as employing a combination of the free-weighting matrix method, Newton-Leibniz formulation and inequality technique, a sliding mode controller is designed to achieve the asymptotical synchronization of the addressed nonidentical neural networks. Moreover, a sliding mode control law is also synthesized to guarantee the reachability of the specified sliding surface. The provided conditions are expressed in terms of linear matrix inequalities, and are dependent on the discrete and distributed time delays as well as leakage delay. A simulation example is given to verify the theoretical results.

Emergence of amplitude death scenario in a network of oscillators under repulsive delay interaction

Energy Technology Data Exchange (ETDEWEB)

Bera, Bidesh K., E-mail: bideshbera18@gmail.com [Physics and Applied Mathematics Unit, Indian Statistical Institute, Kolkata 700108 (India); Hens, Chittaranjan, E-mail: chittaranjanhens@gmail.com [Department of Mathematics, Bar-Ilan University, Ramat Gan 52900 (Israel); Ghosh, Dibakar, E-mail: dibakar@isical.ac.in [Physics and Applied Mathematics Unit, Indian Statistical Institute, Kolkata 700108 (India)

2016-07-15

Highlights: • Amplitude death is observed using repulsive mean coupling. • Analytical conditions for amplitude death are derived. • Effect of asymmetry time delay coupling for death is discussed. - Abstract: We report the existence of amplitude death in a network of identical oscillators under repulsive mean coupling. Amplitude death appears in a globally coupled network of identical oscillators with instantaneous repulsive mean coupling only when the number of oscillators is more than two. We further investigate that, amplitude death may emerge even in two coupled oscillators as well as network of oscillators if we introduce delay time in the repulsive mean coupling. We have analytically derived the region of amplitude death island and find out how strength of delay controls the death regime in two coupled or a large network of coupled oscillators. We have verified our results on network of delayed Mackey–Glass systems where parameters are set in hyperchaotic regime. We have also tested our coupling approach in two paradigmatic limit cycle oscillators: Stuart–Landau and Van der Pol oscillators.

Emergence of amplitude death scenario in a network of oscillators under repulsive delay interaction

International Nuclear Information System (INIS)

Bera, Bidesh K.; Hens, Chittaranjan; Ghosh, Dibakar

2016-01-01

Highlights: • Amplitude death is observed using repulsive mean coupling. • Analytical conditions for amplitude death are derived. • Effect of asymmetry time delay coupling for death is discussed. - Abstract: We report the existence of amplitude death in a network of identical oscillators under repulsive mean coupling. Amplitude death appears in a globally coupled network of identical oscillators with instantaneous repulsive mean coupling only when the number of oscillators is more than two. We further investigate that, amplitude death may emerge even in two coupled oscillators as well as network of oscillators if we introduce delay time in the repulsive mean coupling. We have analytically derived the region of amplitude death island and find out how strength of delay controls the death regime in two coupled or a large network of coupled oscillators. We have verified our results on network of delayed Mackey–Glass systems where parameters are set in hyperchaotic regime. We have also tested our coupling approach in two paradigmatic limit cycle oscillators: Stuart–Landau and Van der Pol oscillators.

Down two steps: Are bilinguals delayed in the acquisition of recursively embedded PPs?

Directory of Open Access Journals (Sweden)

Ana Pérez-Leroux

2017-08-01

Full Text Available The present study examines whether bilingual children are delayed in the ability to produce complex DPs. We elicited production of DPs containing two PP modifiers, in two conditions designed to tease apart the acquisition of an embedding rule from the acquisition of the recursivity of an embedding rule. In the recursive condition, one modifier PP was itself modified by an additional PP. In the non-recursive condition, both PPs sequentially modified the main noun. Participants were 71 English monolingual children and 35 bilinguals between the ages of four and six. The evidence suggested an overall difference between groups, however further analysis revealed that bilinguals differed from monolinguals only insofar as the onset of PP embedding. No specific additional bilingual delay arose from the recursive condition. This suggests that recursive embedding is a resilient domain in language acquisition and supports proposals that link morphosyntactic delays in bilingual children to domains of grammar that are heavily reliant on lexical learning, which would include learning the first instance of PP embedding. --- Original in English.   --- DOI: http://dx.doi.org/10.12957/matraga.2017.28781

Models of the delayed nonlinear Raman response in diatomic gases

International Nuclear Information System (INIS)

Palastro, J. P.; Antonsen, T. M. Jr.; Pearson, A.

2011-01-01

We examine the delayed response of a diatomic gas to a polarizing laser field with the goal of obtaining computationally efficient methods for use with laser pulse propagation simulations. We demonstrate that for broadband pulses, heavy molecules such as O 2 and N 2 , and typical atmospheric temperatures, the initial delayed response requires only classical physics. The linear kinetic Green's function is derived from the Boltzmann equation and shown to be in excellent agreement with full density-matrix calculations. A straightforward perturbation approach for the fully nonlinear, kinetic impulse response is also presented. With the kinetic theory a reduced fluid model of the diatomic gas' orientation is derived. Transport coefficients are introduced to model the kinetic phase mixing of the delayed response. In addition to computational rapidity, the fluid model provides intuition through the use of familiar macroscopic quantities. Both the kinetic and the fluid descriptions predict a nonlinear steady-state alignment after passage of the laser pulse, which in the fluid model is interpreted as an anisotropic temperature of the diatomic fluid with respect to motion about the polarization axis.

A Data-Driven Air Transportation Delay Propagation Model Using Epidemic Process Models

Directory of Open Access Journals (Sweden)

B. Baspinar

2016-01-01

Full Text Available In air transport network management, in addition to defining the performance behavior of the system’s components, identification of their interaction dynamics is a delicate issue in both strategic and tactical decision-making process so as to decide which elements of the system are “controlled” and how. This paper introduces a novel delay propagation model utilizing epidemic spreading process, which enables the definition of novel performance indicators and interaction rates of the elements of the air transportation network. In order to understand the behavior of the delay propagation over the network at different levels, we have constructed two different data-driven epidemic models approximating the dynamics of the system: (a flight-based epidemic model and (b airport-based epidemic model. The flight-based epidemic model utilizing SIS epidemic model focuses on the individual flights where each flight can be in susceptible or infected states. The airport-centric epidemic model, in addition to the flight-to-flight interactions, allows us to define the collective behavior of the airports, which are modeled as metapopulations. In network model construction, we have utilized historical flight-track data of Europe and performed analysis for certain days involving certain disturbances. Through this effort, we have validated the proposed delay propagation models under disruptive events.

Delay selection by spike-timing-dependent plasticity in recurrent networks of spiking neurons receiving oscillatory inputs.

Directory of Open Access Journals (Sweden)

Robert R Kerr

Full Text Available Learning rules, such as spike-timing-dependent plasticity (STDP, change the structure of networks of neurons based on the firing activity. A network level understanding of these mechanisms can help infer how the brain learns patterns and processes information. Previous studies have shown that STDP selectively potentiates feed-forward connections that have specific axonal delays, and that this underlies behavioral functions such as sound localization in the auditory brainstem of the barn owl. In this study, we investigate how STDP leads to the selective potentiation of recurrent connections with different axonal and dendritic delays during oscillatory activity. We develop analytical models of learning with additive STDP in recurrent networks driven by oscillatory inputs, and support the results using simulations with leaky integrate-and-fire neurons. Our results show selective potentiation of connections with specific axonal delays, which depended on the input frequency. In addition, we demonstrate how this can lead to a network becoming selective in the amplitude of its oscillatory response to this frequency. We extend this model of axonal delay selection within a single recurrent network in two ways. First, we show the selective potentiation of connections with a range of both axonal and dendritic delays. Second, we show axonal delay selection between multiple groups receiving out-of-phase, oscillatory inputs. We discuss the application of these models to the formation and activation of neuronal ensembles or cell assemblies in the cortex, and also to missing fundamental pitch perception in the auditory brainstem.

Synchronization of Markovian jumping stochastic complex networks with distributed time delays and probabilistic interval discrete time-varying delays

International Nuclear Information System (INIS)

Li Hongjie; Yue Dong

2010-01-01

The paper investigates the synchronization stability problem for a class of complex dynamical networks with Markovian jumping parameters and mixed time delays. The complex networks consist of m modes and the networks switch from one mode to another according to a Markovian chain with known transition probability. The mixed time delays are composed of discrete and distributed delays, the discrete time delay is assumed to be random and its probability distribution is known a priori. In terms of the probability distribution of the delays, the new type of system model with probability-distribution-dependent parameter matrices is proposed. Based on the stochastic analysis techniques and the properties of the Kronecker product, delay-dependent synchronization stability criteria in the mean square are derived in the form of linear matrix inequalities which can be readily solved by using the LMI toolbox in MATLAB, the solvability of derived conditions depends on not only the size of the delay, but also the probability of the delay-taking values in some intervals. Finally, a numerical example is given to illustrate the feasibility and effectiveness of the proposed method.

Dynamics of Nonlinear Time-Delay Systems

CERN Document Server

Lakshmanan, Muthusamy

2010-01-01

Synchronization of chaotic systems, a patently nonlinear phenomenon, has emerged as a highly active interdisciplinary research topic at the interface of physics, biology, applied mathematics and engineering sciences. In this connection, time-delay systems described by delay differential equations have developed as particularly suitable tools for modeling specific dynamical systems. Indeed, time-delay is ubiquitous in many physical systems, for example due to finite switching speeds of amplifiers in electronic circuits, finite lengths of vehicles in traffic flows, finite signal propagation times in biological networks and circuits, and quite generally whenever memory effects are relevant. This monograph presents the basics of chaotic time-delay systems and their synchronization with an emphasis on the effects of time-delay feedback which give rise to new collective dynamics. Special attention is devoted to scalar chaotic/hyperchaotic time-delay systems, and some higher order models, occurring in different bran...

Delay in the diagnosis and treatment of pulmonary tuberculosis in Uzbekistan: a cross-sectional study.

Science.gov (United States)

Belkina, Tatiana V; Khojiev, Doniyor S; Tillyashaykhov, Mirzagaleb N; Tigay, Zinaida N; Kudenov, Marat U; Tebbens, Jurjen Duintjer; Vlcek, Jiri

2014-11-25

Early diagnosis and prompt effective therapy are crucial for the prevention of tuberculosis (TB) transmission, particularly in regions with high levels of multi-drug resistant TB. This study aimed to evaluate the extent of delay in diagnosis and treatment of TB in Uzbekistan and identify associated risk factors. A cross-sectional study was performed on hospital patients with newly diagnosed TB. The time between the onset of respiratory symptoms and initiation of anti-TB treatment was assessed and delays were divided into patient, health system and total delays. Univariable and multivariable logistic regression analysis was used to evaluate determinants of diagnostic and treatment delay. Among 538 patients enrolled, the median delay from onset of symptoms until treatment with anti-TB drugs was 50 days. Analysis of the factors affecting health-seeking behaviour and timely treatment showed the presence of the patient factor. Self-medication was the first health-seeking action for 231 (43%) patients and proved to be a significant predictor of delay (p = 0.005), as well as coughing (p = 0.009), loss of weight (p = 0.001), and visiting private and primary healthcare facilities (p = 0.03 and p = 0.02, respectively). TB diagnostic and treatment delay was mainly contributed to by patient delay and should be reduced through increasing public awareness of TB symptoms and improving public health-seeking behaviour for timely initiation of anti-TB treatment. Efforts should be made to minimise irrational use of antibiotics and support interventions to restrict over-the-counter availability of antibiotics.

The social cost of congestion games by imposing variable delays

Directory of Open Access Journals (Sweden)

Josep Díaz

2017-12-01

Full Text Available In this study, we describe a new coordination mechanism for non-atomic congestion games that leads to a (selfish social cost which is arbitrarily close to the non-selfish optimal. This mechanism incurs no additional cost, in contrast to tolls that typically differ from the social cost as expressed in terms of delays.

Iterative method for obtaining the prompt and delayed alpha-modes of the diffusion equation

International Nuclear Information System (INIS)

Singh, K.P.; Degweker, S.B.; Modak, R.S.; Singh, Kanchhi

2011-01-01

Highlights: → A method for obtaining α-modes of the neutron diffusion equation has been developed. → The difference between the prompt and delayed modes is more pronounced for the higher modes. → Prompt and delayed modes differ more in reflector region. - Abstract: Higher modes of the neutron diffusion equation are required in some applications such as second order perturbation theory, and modal kinetics. In an earlier paper we had discussed a method for computing the α-modes of the diffusion equation. The discussion assumed that all neutrons are prompt. The present paper describes an extension of the method for finding the α-modes of diffusion equation with the inclusion of delayed neutrons. Such modes are particularly suitable for expanding the time dependent flux in a reactor for describing transients in a reactor. The method is illustrated by applying it to a three dimensional heavy water reactor model problem. The problem is solved in two and three neutron energy groups and with one and six delayed neutron groups. The results show that while the delayed α-modes are similar to λ-modes they are quite different from prompt modes. The difference gets progressively larger as we go to higher modes.

Bifurcation and synchronization of synaptically coupled FHN models with time delay

International Nuclear Information System (INIS)

Wang Qingyun; Lu Qishao; Chen Guanrong; Feng Zhaosheng; Duan Lixia

2009-01-01

This paper presents an investigation of dynamics of the coupled nonidentical FHN models with synaptic connection, which can exhibit rich bifurcation behavior with variation of the coupling strength. With the time delay being introduced, the coupled neurons may display a transition from the original chaotic motions to periodic ones, which is accompanied by complex bifurcation scenario. At the same time, synchronization of the coupled neurons is studied in terms of their mean frequencies. We also find that the small time delay can induce new period windows with the coupling strength increasing. Moreover, it is found that synchronization of the coupled neurons can be achieved in some parameter ranges and related to their bifurcation transition. Bifurcation diagrams are obtained numerically or analytically from the mathematical model and the parameter regions of different behavior are clarified.

Delayed rule following

OpenAIRE

Schmitt, David R.

2001-01-01

Although the elements of a fully stated rule (discriminative stimulus [SD], some behavior, and a consequence) can occur nearly contemporaneously with the statement of the rule, there is often a delay between the rule statement and the SD. The effects of this delay on rule following have not been studied in behavior analysis, but they have been investigated in rule-like settings in the areas of prospective memory (remembering to do something in the future) and goal pursuit. Discriminative even...

Probing the limits of delay intolerance: preliminary young adult data from the Delay Frustration Task (DeFT).

Science.gov (United States)

Bitsakou, Paraskevi; Antrop, Inge; Wiersema, Jan Roelf; Sonuga-Barke, Edmund J S

2006-02-15

Delay intolerance/aversion is one amongst a number of candidate neuropsychological endophenotypes for ADHD. Pilot data suggest that, because of potential ceiling effects, simple choice measures of delay tolerance used for children are probably not appropriate for adolescents and adults. The Delay Frustration Task (DeFT) is a new measure of delay intolerance, designed to be used in a similar form with adolescents and adults as well as children. In it delay frustration is indexed as the number and duration of responses made on a response key during a series of unpredictable and unsignalled delay periods, which interrupt the completion of a simple computer-based tests. The aim of this study was to provide preliminary data on the applicability of the task in a sample of young adults. The DeFT was administered to 49 male and female undergraduate students selected from a normal population-base. Their mean age was 23.14 (S.D.=1.54). Three measures of delay frustration were recorded across time intervals during the response window; the number of responses, their duration and their combined product (total time button was pressed) was calculated for each second interval bin during the post-response delay period. The AARS and HADS were used as screening questionnaires for ADHD and anxiety behaviour, respectively. The results indicated that young adults with high-ADHD symptoms scores pressed the button more than those with low ADHD scores during the post-response delay condition. While both groups increased responding across time within intervals this was significantly more marked in the high-ADHD symptom group. These effects became more pronounced when anxiety was controlled. Young adults with high-ADHD symptoms appear to be more sensitive to the imposition of unscheduled and unsignalled delay during a simple maths test. DeFT may provide a useful index of delay tolerance in young adults with ADHD. Future research needs to examine DeFT performance in different age groups and

Adaptive modification of the delayed feedback control algorithm with a continuously varying time delay

International Nuclear Information System (INIS)

Pyragas, V.; Pyragas, K.

2011-01-01

We propose a simple adaptive delayed feedback control algorithm for stabilization of unstable periodic orbits with unknown periods. The state dependent time delay is varied continuously towards the period of controlled orbit according to a gradient-descent method realized through three simple ordinary differential equations. We demonstrate the efficiency of the algorithm with the Roessler and Mackey-Glass chaotic systems. The stability of the controlled orbits is proven by computation of the Lyapunov exponents of linearized equations. -- Highlights: → A simple adaptive modification of the delayed feedback control algorithm is proposed. → It enables the control of unstable periodic orbits with unknown periods. → The delay time is varied continuously according to a gradient descend method. → The algorithm is embodied by three simple ordinary differential equations. → The validity of the algorithm is proven by computation of the Lyapunov exponents.

Temperature Dependent Wire Delay Estimation in Floorplanning

DEFF Research Database (Denmark)

Winther, Andreas Thor; Liu, Wei; Nannarelli, Alberto

2011-01-01

Due to large variations in temperature in VLSI circuits and the linear relationship between metal resistance and temperature, the delay through wires of the same length can be different. Traditional thermal aware floorplanning algorithms use wirelength to estimate delay and routability. In this w......Due to large variations in temperature in VLSI circuits and the linear relationship between metal resistance and temperature, the delay through wires of the same length can be different. Traditional thermal aware floorplanning algorithms use wirelength to estimate delay and routability....... In this work, we show that using wirelength as the evaluation metric does not always produce a floorplan with the shortest delay. We propose a temperature dependent wire delay estimation method for thermal aware floorplanning algorithms, which takes into account the thermal effect on wire delay. The experiment...

Permutation entropy with vector embedding delays

Science.gov (United States)

Little, Douglas J.; Kane, Deb M.

2017-12-01

Permutation entropy (PE) is a statistic used widely for the detection of structure within a time series. Embedding delay times at which the PE is reduced are characteristic timescales for which such structure exists. Here, a generalized scheme is investigated where embedding delays are represented by vectors rather than scalars, permitting PE to be calculated over a (D -1 ) -dimensional space, where D is the embedding dimension. This scheme is applied to numerically generated noise, sine wave and logistic map series, and experimental data sets taken from a vertical-cavity surface emitting laser exhibiting temporally localized pulse structures within the round-trip time of the laser cavity. Results are visualized as PE maps as a function of embedding delay, with low PE values indicating combinations of embedding delays where correlation structure is present. It is demonstrated that vector embedding delays enable identification of structure that is ambiguous or masked, when the embedding delay is constrained to scalar form.

CGI delay compensation. [Computer Generated Image

Science.gov (United States)

Mcfarland, R. E.

1986-01-01

Computer-generated graphics in real-time helicopter simulation produces objectionable scene-presentation time delays. In the flight simulation laboratory at Ames Research Center, it has been determined that these delays have an adverse influence on pilot performance during agressive tasks such as nap of the earth (NOE) maneuvers. Using contemporary equipment, computer generated image (CGI) time delays are an unavoidable consequence of the operations required for scene generation. However, providing that magnitude distortions at higher frequencies are tolerable, delay compensation is possible over a restricted frequency range. This range, assumed to have an upper limit of perhaps 10 or 15 rad/sec, conforms approximately to the bandwidth associated with helicopter handling qualities research. A compensation algorithm is introduced here and evaluated in terms of tradeoffs in frequency responses. The algorithm has a discrete basis and accommodates both a large, constant transport delay interval and a periodic delay interval, as associated with asynchronous operations.

New delay-dependent absolute stability criteria for Lur'e systems with time-varying delay

Science.gov (United States)

Chen, Yonggang; Bi, Weiping; Li, Wenlin

2011-07-01

In this article, the absolute stability problem is investigated for Lur'e systems with time-varying delay and sector-bounded nonlinearity. By employing the delay fractioning idea, the new augmented Lyapunov functional is first constructed. Then, by introducing some slack matrices and by reserving the useful term when estimating the upper bound of the derivative of Lyapunov functional, the new delay-dependent absolute stability criteria are derived in terms of linear matrix inequalities. Several numerical examples are presented to show the effectiveness and the less conservativeness of the proposed method.

Improvement of Klobuchar model for GNSS single-frequency ionospheric delay corrections

Science.gov (United States)

Wang, Ningbo; Yuan, Yunbin; Li, Zishen; Huo, Xingliang

2016-04-01

Broadcast ionospheric model is currently an effective approach to mitigate the ionospheric time delay for real-time Global Navigation Satellite System (GNSS) single-frequency users. Klobuchar coefficients transmitted in Global Positioning System (GPS) navigation message have been widely used in various GNSS positioning and navigation applications; however, this model can only reduce the ionospheric error by approximately 50% in mid-latitudes. With the emerging BeiDou and Galileo, as well as the modernization of GPS and GLONASS, more precise ionospheric correction models or algorithms are required by GNSS single-frequency users. Numerical analysis of the initial phase and nighttime term in Klobuchar algorithm demonstrates that more parameters should be introduced to better describe the variation of nighttime ionospheric total electron content (TEC). In view of this, several schemes are proposed for the improvement of Klobuchar algorithm. Performance of these improved Klobuchar-like models are validated over the continental and oceanic regions during high (2002) and low (2006) levels of solar activities, respectively. Over the continental region, GPS TEC generated from 35 International GNSS Service (IGS) and the Crust Movement Observation Network of China (CMONOC) stations are used as references. Over the oceanic region, TEC data from TOPEX/Poseidon and JASON-1 altimeters are used for comparison. A ten-parameter Klobuchar-like model, which describes the nighttime term as a linear function of geomagnetic latitude, is finally proposed for GNSS single-frequency ionospheric corrections. Compared to GPS TEC, while GPS broadcast model can correct for 55.0% and 49.5% of the ionospheric delay for the year 2002 and 2006, respectively, the proposed ten-parameter Klobuchar-like model can reduce the ionospheric error by 68.4% and 64.7% for the same period. Compared to TOPEX/Poseidon and JASON-1 TEC, the improved ten-parameter Klobuchar-like model can mitigate the ionospheric

Pinning synchronization of the complex networks with non-delayed and delayed coupling

International Nuclear Information System (INIS)

Guo Wanli; Austin, Francis; Chen Shihua; Sun Wen

2009-01-01

In this Letter, without assuming the symmetry of the coupling matrix, we investigate the global synchronization of the complex networks with non-delayed and delayed coupling based on the pinning controllers. Some sufficient conditions for the global synchronization by adding linear and adaptive feedback controllers to a part of nodes are obtained. Numerical examples are also provided to demonstrate the effectiveness of the theory.

Simultaneous auto-calibration and gradient delays estimation (SAGE) in non-Cartesian parallel MRI using low-rank constraints.

Science.gov (United States)

Jiang, Wenwen; Larson, Peder E Z; Lustig, Michael

2018-03-09

To correct gradient timing delays in non-Cartesian MRI while simultaneously recovering corruption-free auto-calibration data for parallel imaging, without additional calibration scans. The calibration matrix constructed from multi-channel k-space data should be inherently low-rank. This property is used to construct reconstruction kernels or sensitivity maps. Delays between the gradient hardware across different axes and RF receive chain, which are relatively benign in Cartesian MRI (excluding EPI), lead to trajectory deviations and hence data inconsistencies for non-Cartesian trajectories. These in turn lead to higher rank and corrupted calibration information which hampers the reconstruction. Here, a method named Simultaneous Auto-calibration and Gradient delays Estimation (SAGE) is proposed that estimates the actual k-space trajectory while simultaneously recovering the uncorrupted auto-calibration data. This is done by estimating the gradient delays that result in the lowest rank of the calibration matrix. The Gauss-Newton method is used to solve the non-linear problem. The method is validated in simulations using center-out radial, projection reconstruction and spiral trajectories. Feasibility is demonstrated on phantom and in vivo scans with center-out radial and projection reconstruction trajectories. SAGE is able to estimate gradient timing delays with high accuracy at a signal to noise ratio level as low as 5. The method is able to effectively remove artifacts resulting from gradient timing delays and restore image quality in center-out radial, projection reconstruction, and spiral trajectories. The low-rank based method introduced simultaneously estimates gradient timing delays and provides accurate auto-calibration data for improved image quality, without any additional calibration scans. © 2018 International Society for Magnetic Resonance in Medicine.

#FakeNobelDelayReasons

CERN Multimedia

2013-01-01

Tuesday’s hour-long delay of the Nobel Prize in Physics announcement was (and still is) quite the cause for speculation. But on the Twittersphere, it was simply the catalyst for some fantastic puns, so-bad-they're-good physics jokes and other shenanigans. Here are some of our favourite #FakeNobelDelayReasons.    

Location Estimation using Delayed Measurements

DEFF Research Database (Denmark)

Bak, Martin; Larsen, Thomas Dall; Nørgård, Peter Magnus

1998-01-01

When combining data from various sensors it is vital to acknowledge possible measurement delays. Furthermore, the sensor fusion algorithm, often a Kalman filter, should be modified in order to handle the delay. The paper examines different possibilities for handling delays and applies a new techn...... technique to a sensor fusion system for estimating the location of an autonomous guided vehicle. The system fuses encoder and vision measurements in an extended Kalman filter. Results from experiments in a real environment are reported...

Delayed complications of radiotherapy treatment for nasopharyngeal carcinoma: imaging findings

International Nuclear Information System (INIS)

King, A.D.; Ahuja, A.T.; Yeung, D.K.; Wong, J.K.T.; Lee, Y.Y.P.; Lam, W.W.M.; Ho, S.S.M.; Yu, S.C.H.; Leung, S.-F.

2007-01-01

Radiotherapy is used to treat a wide variety of head and neck tumours that arise in and around the skull base. The delayed effects of radiation damages a range of structures, including the nervous system, bone, major vessels, mucus membranes, pituitary and salivary glands, as well as increasing the risk of radiation-induced neoplasms. In this review the complications resulting from radiation treatment for nasopharyngeal carcinoma (NPC), a cancer treated with a high dose of radiation to a fairly large region, are illustrated. Many patients with NPC have a long-term survival, so are at risk of developing delayed radiation effects, and hence may demonstrate a wide range of complications on imaging. Other tumours around the skull base treated with radiotherapy include meningiomas, chordomas, chondrosarcomas, pituitary adenomas, paranasal sinus and nasal cavity tumours. In these cases similar complications may be encountered on imaging, although the severity, incidence and location will vary

$\\beta$-delayed neutron spectroscopy of $^{130-132}$ Cd isotopes with the ISOLDE decay station and the VANDLE array

CERN Multimedia

We propose to use the new ISOLDE decay station and the neutron detector VANDLE to measure the $\\beta$-delayed neutron emission of N=82-84 $^{130-132}$Cd isotopes. The large delayed neutron emission probability observed in a previous ISOLDE measurement is indicative of the Gamow-Teller transitions due to the decay of deep core neutrons. Core Gamow-Teller decay has been experimentally proven in the $^{78}$Ni region for the N>50 nuclei using the VANDLE array. The spectroscopic measurement of delayed neutron emission along the cadmium isotopic chain will allow us to track the evolution of the single particle states and the shell gap.

Utilization of GPS Tropospheric Delays for Climate Research

International Nuclear Information System (INIS)

Suparta, Wayan

2017-01-01

The tropospheric delay is one of the main error sources in Global Positioning Systems (GPS) and its impact plays a crucial role in near real-time weather forecasting. Accessibility and accurate estimation of this parameter are essential for weather and climate research. Advances in GPS application has allowed the measurements of zenith tropospheric delay (ZTD) in all weather conditions and on a global scale with fine temporal and spatial resolution. In addition to the rapid advancement of GPS technology and informatics and the development of research in the field of Earth and Planetary Sciences, the GPS data has been available free of charge. Now only required sophisticated processing techniques but user friendly. On the other hand, the ZTD parameter obtained from the models or measurements needs to be converted into precipitable water vapor (PWV) to make it more useful as a component of weather forecasting and analysis atmospheric hazards such as tropical storms, flash floods, landslide, pollution, and earthquake as well as for climate change studies. This paper addresses the determination of ZTD as a signal error or delay source during the propagation from the satellite to a receiver on the ground and is a key driving force behind the atmospheric events. Some results in terms of ZTD and PWV will be highlighted in this paper. (paper)

MR findings of congenital craniocerebral anomaly: correlation with seizures and development delay

International Nuclear Information System (INIS)

Ko, Seog Wan; Seo, Jeong Jin; Kim, Yun Hyeon; Yoon, Jong Hun; Kim, Hyun Ju; Kim, Hyeong Kil; Kang, Heoung Keun; Chung, Hyon De

1995-01-01

To evaluate characteristic MR findings of craniocerebral anomaly and its relationship with neurologic manifestations. We retrospectively reviewed MR images of 36 patients with craniocerebral anomaly diagnosed by MRI and clinical courses. We correlated the characteristic MR findings in 41 lesions with neurologic manifestations focusing on seizures and developmental delay. Twenty-three patients with seizures consisted of 14 patients(60%) with neuronal migration disorders and seven(30%) with phakomatosis, among which 18 patients(78%) had generalized type of seizures. Locations of the lesions were the parietal lobes in 11 patients(52%) and the subependymal or periventricular regions in seven(33%). Two patients with tuberous sclerosis had the lesions in both parietal and subependymal areas. Nine patients had the signs of developmental delay that were seen in the four(44%) with schizencephaly, two (22%) with tuberous sclerosis, two(22%) with heterotopia, and noe(11%) with pachygyria. Neuronal migration anomaly was relatively common lesion that presented neurologic festations such as seizures and developmental delay. Generalized type of seizures were common. We were able to diagnose these anomalies using the MRI that helped establish therapeutic plans

Does goal relevant episodic future thinking amplify the effect on delay discounting?

Science.gov (United States)

O'Donnell, Sara; Oluyomi Daniel, Tinuke; Epstein, Leonard H

2017-05-01

Delay discounting (DD) is the preference for smaller immediate rewards over larger delayed rewards. Research shows episodic future thinking (EFT), or mentally simulating future experiences, reframes the choice between small immediate and larger delayed rewards, and can reduce DD. Only general EFT has been studied, whereby people reframe decisions in terms of non-goal related future events. Since future thinking is often goal-oriented and leads to greater activation of brain regions involved in prospection, goal-oriented EFT may be associated with greater reductions in DD than general goal-unrelated EFT. The present study (n=104, M age =22.25, SD=3.42; 50% Female) used a between-subjects 2×2 factorial design with type of episodic thinking (Goal, General) and temporal perspective (Episodic future versus recent thinking; EFT vs ERT) as between factors. Results showed a significant reduction in DD for EFT groups (p<0.001, Cohen's d effect size=0.89), and goal-EFT was more effective than general-EFT on reducing DD (p=0.03, d=0.64). Copyright © 2017 Elsevier Inc. All rights reserved.

Analyzing delay causes in Egyptian construction projects

Directory of Open Access Journals (Sweden)

Mohamed M. Marzouk

2014-01-01

Full Text Available Construction delays are common problems in civil engineering projects in Egypt. These problems occur frequently during project life-time leading to disputes and litigation. Therefore, it is essential to study and analyze causes of construction delays. This research presents a list of construction delay causes retrieved from literature. The feedback of construction experts was obtained through interviews. Subsequently, a questionnaire survey was prepared. The questionnaire survey was distributed to thirty-three construction experts who represent owners, consultants, and contractor’s organizations. Frequency Index, Severity Index, and Importance Index are calculated and according to the highest values of them the top ten delay causes of construction projects in Egypt are determined. A case study is analyzed and compared to the most important delay causes in the research. Statistical analysis is carried out using analysis of variance ANOVA method to test delay causes, obtained from the survey. The test results reveal good correlation between groups while there is significant difference between them for some delay causes and finally roadmap for prioritizing delay causes groups is presented.

Amplification of weak signals via the non-adiabatic regime of stochastic resonance in a bistable dynamical system with time delay

International Nuclear Information System (INIS)

Du Luchun; Mei Dongcheng

2011-01-01

The non-adiabatic regime of stochastic resonance (SR) in a bistable system with time delay, an additive white noise and a periodic signal was investigated. The signal power amplification η was employed to characterize the SR of the system. The simulation results indicate that (i) in the case of intermediate frequency Ω of the periodic signal, the typical behavior of SR is lowered monotonically by increasing the delay time τ; in the case of large Ω, τ weakens the SR behavior and then enhances it, with a non-monotonic behavior as a function of time delay; (ii) time delay induces SR when A is above the threshold, whereas no such resonance exists in the absence of time delay; (iii) time delay induces a transition from bimodal to unimodal configuration of η; (iv) varying the particular form of time delay results in different phenomena.

Robust Moving Horizon H∞ Control of Discrete Time-Delayed Systems with Interval Time-Varying Delays

Directory of Open Access Journals (Sweden)

F. Yıldız Tascikaraoglu

2014-01-01

Full Text Available In this study, design of a delay-dependent type moving horizon state-feedback control (MHHC is considered for a class of linear discrete-time system subject to time-varying state delays, norm-bounded uncertainties, and disturbances with bounded energies. The closed-loop robust stability and robust performance problems are considered to overcome the instability and poor disturbance rejection performance due to the existence of parametric uncertainties and time-delay appeared in the system dynamics. Utilizing a discrete-time Lyapunov-Krasovskii functional, some delay-dependent linear matrix inequality (LMI based conditions are provided. It is shown that if one can find a feasible solution set for these LMI conditions iteratively at each step of run-time, then we can construct a control law which guarantees the closed-loop asymptotic stability, maximum disturbance rejection performance, and closed-loop dissipativity in view of the actuator limitations. Two numerical examples with simulations on a nominal and uncertain discrete-time, time-delayed systems, are presented at the end, in order to demonstrate the efficiency of the proposed method.

A novel delay-dependent criterion for delayed neural networks of neutral type

International Nuclear Information System (INIS)

Lee, S.M.; Kwon, O.M.; Park, Ju H.

2010-01-01

This Letter considers a robust stability analysis method for delayed neural networks of neutral type. By constructing a new Lyapunov functional, a novel delay-dependent criterion for the stability is derived in terms of LMIs (linear matrix inequalities). A less conservative stability criterion is derived by using nonlinear properties of the activation function of the neural networks. Two numerical examples are illustrated to show the effectiveness of the proposed method.

Beta-delayed fission and neutron emission calculations for the actinide cosmochronometers

International Nuclear Information System (INIS)

Meyer, B.S.; Howard, W.M.; Mathews, G.J.; Takahashi, K.; Moeller, P.; Leander, G.A.

1989-01-01

The Gamow-Teller beta-strength distributions for 19 neutron-rich nuclei, including ten of interest for the production of the actinide cosmochronometers, are computed microscopically with a code that treats nuclear deformation explicitly. The strength distributions are then used to calculate the beta-delayed fission, neutron emission, and gamma deexcitation probabilities for these nuclei. Fission is treated both in the complete damping and WKB approximations for penetrabilities through the nuclear potential-energy surface. The resulting fission probabilities differ by factors of 2 to 3 or more from the results of previous calculations using microscopically computed beta-strength distributions around the region of greatest interest for production of the cosmochronometers. The indications are that a consistent treatment of nuclear deformation, fission barriers, and beta-strength functions is important in the calculation of delayed fission probabilities and the production of the actinide cosmochronometers. Since we show that the results are very sensitive to relatively small changes in model assumptions, large chronometric ages for the Galaxy based upon high beta-delayed fission probabilities derived from an inconsistent set of nuclear data calculations must be considered quite uncertain

A model for integrating elementary neural functions into delayed-response behavior.

Directory of Open Access Journals (Sweden)

Thomas Gisiger

2006-04-01

Full Text Available It is well established that various cortical regions can implement a wide array of neural processes, yet the mechanisms which integrate these processes into behavior-producing, brain-scale activity remain elusive. We propose that an important role in this respect might be played by executive structures controlling the traffic of information between the cortical regions involved. To illustrate this hypothesis, we present a neural network model comprising a set of interconnected structures harboring stimulus-related activity (visual representation, working memory, and planning, and a group of executive units with task-related activity patterns that manage the information flowing between them. The resulting dynamics allows the network to perform the dual task of either retaining an image during a delay (delayed-matching to sample task, or recalling from this image another one that has been associated with it during training (delayed-pair association task. The model reproduces behavioral and electrophysiological data gathered on the inferior temporal and prefrontal cortices of primates performing these same tasks. It also makes predictions on how neural activity coding for the recall of the image associated with the sample emerges and becomes prospective during the training phase. The network dynamics proves to be very stable against perturbations, and it exhibits signs of scale-invariant organization and cooperativity. The present network represents a possible neural implementation for active, top-down, prospective memory retrieval in primates. The model suggests that brain activity leading to performance of cognitive tasks might be organized in modular fashion, simple neural functions becoming integrated into more complex behavior by executive structures harbored in prefrontal cortex and/or basal ganglia.

A model for integrating elementary neural functions into delayed-response behavior.

Science.gov (United States)

Gisiger, Thomas; Kerszberg, Michel

2006-04-01

It is well established that various cortical regions can implement a wide array of neural processes, yet the mechanisms which integrate these processes into behavior-producing, brain-scale activity remain elusive. We propose that an important role in this respect might be played by executive structures controlling the traffic of information between the cortical regions involved. To illustrate this hypothesis, we present a neural network model comprising a set of interconnected structures harboring stimulus-related activity (visual representation, working memory, and planning), and a group of executive units with task-related activity patterns that manage the information flowing between them. The resulting dynamics allows the network to perform the dual task of either retaining an image during a delay (delayed-matching to sample task), or recalling from this image another one that has been associated with it during training (delayed-pair association task). The model reproduces behavioral and electrophysiological data gathered on the inferior temporal and prefrontal cortices of primates performing these same tasks. It also makes predictions on how neural activity coding for the recall of the image associated with the sample emerges and becomes prospective during the training phase. The network dynamics proves to be very stable against perturbations, and it exhibits signs of scale-invariant organization and cooperativity. The present network represents a possible neural implementation for active, top-down, prospective memory retrieval in primates. The model suggests that brain activity leading to performance of cognitive tasks might be organized in modular fashion, simple neural functions becoming integrated into more complex behavior by executive structures harbored in prefrontal cortex and/or basal ganglia.

(3)He pO2 mapping is limited by delayed-ventilation and diffusion in chronic obstructive pulmonary disease.

Science.gov (United States)

Marshall, Helen; Parra-Robles, Juan; Deppe, Martin H; Lipson, David A; Lawson, Rod; Wild, Jim M

2014-03-01

Lung pO2 mapping with (3)He MRI assumes that the sources of signal decay with time during a breath-hold are radiofrequency depolarization and oxygen-dependent T1 relaxation, but the method is sensitive to other sources of spatio-temporal signal change such as diffusion. The purpose of this work was to assess the use of (3)He pO2 mapping in patients with chronic obstructive pulmonary disease. Ten patients with moderate to severe chronic obstructive pulmonary disease were scanned with a 3D single breath-hold pO2 mapping sequence. Images showed signal increasing over time in some lung regions due to delayed ventilation during breath-hold. Regions of physically unrealistic negative pO2 values were seen in all patients, and regional mean pO2 values of -0.3 bar were measured in the two patients most affected by delayed ventilation (where mean time to signal onset was 3-4 s). Movement of gas within the lungs during breath-hold causes regional changes in signal over time that are not related to oxygen concentration, leading to erroneous pO2 measurements using the linear oxygen-dependent signal decay model. These spatio-temporal sources of signal change cannot be reliably separated at present, making pO2 mapping using this methodology unreliable in chronic obstructive pulmonary disease patients with significant bullous emphysema or delayed ventilation. Copyright © 2013 Wiley Periodicals, Inc.

Clinical Significance of Reverse Redistribution Phenomenon on Delayed Tc-99m Tetrofosmin Myocardial Perfusion Imaging in Patients with Acute Myocardial Infarction

International Nuclear Information System (INIS)

Park, Soon Ah; Kim, Dae Weung; Kim, Chang Guhn; Jeong, Jin Won; Kim, Nam Ho; Yun, Kyeong Ho

2009-01-01

This study was performed to investigate the clinical significance of reverse redistribution (RR) phenomenon detected on delayed Tc-99m tetrofosmin myocardial single photon emission computed tomography (SPECT) in patients with acute myocardial infarction after revascularization. A Tc-99m tetrofrosmin myocardial SPECT was performed in 67 consecutive patients after revascularization for acute myocardial infarction. Myocardial SPECT imaging was performed for early imaging at 40 min and for delayed imaging at 180 min after reinjection at myocardial stress. Regional myocardial uptakes were scored by 4-point scoring in the left ventricular wall divided into 17 segments. Reverse redistribution was defined as an increase of more than 2 point in the activity score on the delayed image. Follow-up myocardial SPECT and coronary angiography (CAG) were performed 9 months later. On myocardial SPECT performed following revascularization, RR was observed in 100 of all 319 segments (31%) and in 43 patients (64%). The abnormalities of perfusion and regional wall motion were more severe in the patients with RR compared to those without RR (p<0.05). On follow-up myocardial SPECT, the myocardial perfusion, regional wall motion, and myocardial thickness were significantly improved in the patients with RR (p<0.05) however, these changes were not significant in those without RR. There was no significant difference between the patients with RR and those without RR in the occurrence of restenosis on CAG. In patients with acute myocardial infarction, the regions showing the RR phenomenon on delayed Tc-99m tetrofosmin SPECT may reflect viable myocardium and indicate recovery of salvaged myocardium

Reasons for diagnostic delay in gynecological malignancies

DEFF Research Database (Denmark)

Vandborg, Mai Partridge; Christensen, René dePont Christensen; Kragstrup, Jakob

2011-01-01

(≤ or > 60 years), performance of gynecological examination by the GP and notification of cancer suspicion on first referral from GP’s on the diagnostic delay (short delay ≤90 days and long delay >90 days). Results Across cancer type a median total delay of 101 days was observed. The 10% of women......Aim The primary aim of this study was to identify and describe different delay types in women with gynecologic cancer, and to analyze the relationship between diagnostic delay and a number of characteristics for patients, cancers and the health care system. Setting A cohort study of women newly......) and The Danish Gynecological Cancer Database (DGCD). 161 women were included; ovarian cancer: 63, endometrial cancer: 50, cervical cancer: 34 and vulvar cancer: 14. Outcome measures were different delay types counted in days and the influence of four clinical important variables: Presence of alarm symptoms, age...

Development of a subway operation incident delay model using accelerated failure time approaches.

Science.gov (United States)

Weng, Jinxian; Zheng, Yang; Yan, Xuedong; Meng, Qiang

2014-12-01

This study aims to develop a subway operational incident delay model using the parametric accelerated time failure (AFT) approach. Six parametric AFT models including the log-logistic, lognormal and Weibull models, with fixed and random parameters are built based on the Hong Kong subway operation incident data from 2005 to 2012, respectively. In addition, the Weibull model with gamma heterogeneity is also considered to compare the model performance. The goodness-of-fit test results show that the log-logistic AFT model with random parameters is most suitable for estimating the subway incident delay. First, the results show that a longer subway operation incident delay is highly correlated with the following factors: power cable failure, signal cable failure, turnout communication disruption and crashes involving a casualty. Vehicle failure makes the least impact on the increment of subway operation incident delay. According to these results, several possible measures, such as the use of short-distance and wireless communication technology (e.g., Wifi and Zigbee) are suggested to shorten the delay caused by subway operation incidents. Finally, the temporal transferability test results show that the developed log-logistic AFT model with random parameters is stable over time. Copyright © 2014 Elsevier Ltd. All rights reserved.

An Epidemic Model of Computer Worms with Time Delay and Variable Infection Rate

Directory of Open Access Journals (Sweden)

Yu Yao

2018-01-01

Full Text Available With rapid development of Internet, network security issues become increasingly serious. Temporary patches have been put on the infectious hosts, which may lose efficacy on occasions. This leads to a time delay when vaccinated hosts change to susceptible hosts. On the other hand, the worm infection is usually a nonlinear process. Considering the actual situation, a variable infection rate is introduced to describe the spread process of worms. According to above aspects, we propose a time-delayed worm propagation model with variable infection rate. Then the existence condition and the stability of the positive equilibrium are derived. Due to the existence of time delay, the worm propagation system may be unstable and out of control. Moreover, the threshold τ0 of Hopf bifurcation is obtained. The worm propagation system is stable if time delay is less than τ0. When time delay is over τ0, the system will be unstable. In addition, numerical experiments have been performed, which can match the conclusions we deduce. The numerical experiments also show that there exists a threshold in the parameter a, which implies that we should choose appropriate infection rate β(t to constrain worm prevalence. Finally, simulation experiments are carried out to prove the validity of our conclusions.

45 CFR 162.925 - Additional requirements for health plans.

Science.gov (United States)

2010-10-01

... clearinghouse to receive, process, or transmit a standard transaction may not charge fees or costs in excess of... RELATED REQUIREMENTS ADMINISTRATIVE REQUIREMENTS General Provisions for Transactions § 162.925 Additional... transaction as a standard transaction, the health plan must do so. (2) A health plan may not delay or reject a...

Nuclear size and cell division delay

International Nuclear Information System (INIS)

Bird, R.P.

1986-01-01

Radiation-induced division delay has been linked to damage at the nuclear envelope. Further, cells in G 2 phase are drastically arrested by high LET radiation such that single particles traversing cell nuclei may produce measurable division delay. A modest effort was initiated using two related cell lines of different size, near-diploid cells and near-tetraploid cells of Chinese hamster origin, to compare their sensitivity for radiation-induced division delay. If the nuclear surface is the critical target, then a larger nuclear cross-section presented to an alpha-particle beam should exhibit delay induced by a lesser particle fluence. Preliminary estimates of the extent of delay in asynchronous cultures following low doses of gamma-irradiation or of alpha-irradiation were made by in-situ observation of the time of onset of mitosis and by fixation and staining of cultures to determine the mitotic index as a function of time after irradiation. The basic approach to evaluating division delay will be to use Colecemid to accumulate mitotic cells over a period of time

Cell cycle related /sup 125/IUDR-induced-division delay

International Nuclear Information System (INIS)

Scheniderman, M.H.; Hofer, K.G.

1987-01-01

A series of experiments were run to determine if /sup 125/I-decays, in /sup 125/IUdR labeled DNA, specifically accumulated at 1, 3, 5, 7 and 9 hours after plating labeled mitotic cells caused a change in the rate or time of cell entry into mitosis. To accomplish this, a pool of labeled mitotic cells was selected in mitosis and plated in replicate flasks. /sup 125/I decays were accumulated in groups of cells by cooling (4 0 C) for 2 hours starting at the designated times. After rewarding, colcemid was added to arrest cells in mitosis. The rate of cell progression into mitosis for each cell cycle time of accumulation was determined by scoring the mitotic index of cells sampled as a function of time after addition of the colcemid. The results are summarized: (1) Decays from /sup 125/I in /sup 125/I(UdR) labeled DNA reduced the rate of cell progression into mitosis and delayed the time of initiation of mitosis. (2) The reduced rate of progression and the delayed time of initiation of mitosis were independent of the cell cycle time that /sup 125/I-decays were accumulated. (3) The reduced rate of progression after cell cycle accumulation of /sup 125/I decay was statistically indistinguishable from the corresponding controls. (4) The delayed initiation of mitosis after specific cell cycle accumulation of /sup 125/I- decays was greater than the corresponding control. The relationship of these data to DNA and non-DNA division delay target(s) is emphasized

Delayed Ejaculation

Science.gov (United States)

... cases, it is due to a combination of physical and psychological concerns. Psychological causes of delayed ejaculation include: Depression, anxiety or other mental health conditions Relationship problems due to stress, poor communication ...

The influence of single neuron dynamics and network topology on time delay-induced multiple synchronous behaviors in inhibitory coupled network

International Nuclear Information System (INIS)

Zhao, Zhiguo; Gu, Huaguang

2015-01-01

Highlights: • Time delay-induced multiple synchronous behaviors was simulated in neuronal networks. • Multiple behaviors appear at time delays shorter than a bursting period of neurons. • The more spikes per burst of bursting, the more synchronous regions of time delay. • From regular to random via small-world networks, synchronous degree becomes weak. • An interpretation of the multiple behaviors and the influence of network are provided. - Abstract: Time delay induced-multiple synchronous behaviors are simulated in neuronal network composed of many inhibitory neurons and appear at different time delays shorter than a period of endogenous bursting of individual neurons. It is different from previous investigations wherein only one of multiple synchronous behaviors appears at time delay shorter than a period of endogenous firing and others appear at time delay longer than the period duration. The bursting patterns of the synchronous behaviors are identified based on the dynamics of an individual neuron stimulated by a signal similar to the inhibitory coupling current, which is applied at the decaying branch of a spike and suitable phase within the quiescent state of the endogenous bursting. If a burst of endogenous bursting contains more spikes, the synchronous behaviors appear at more regions of time delay. As the coupling strength increases, the multiple synchronous behaviors appear in a sequence because the different threshold of coupling current or strength is needed to achieve synchronous behaviors. From regular, to small-world, and to random networks, synchronous degree of the multiple synchronous behaviors becomes weak, and synchronous bursting patterns with lower spikes per burst disappear, which is properly interpreted by the difference of coupling current between neurons induced by different degree and the high threshold of coupling current to achieve synchronization for the absent synchronous bursting patterns. The results of the influence of

Outcomes of Neonatal Candidiasis: The Impact of Delayed Initiation of Antifungal Therapy

Directory of Open Access Journals (Sweden)

Heather Cahan

2011-01-01

Results. Sixty-three newborns with invasive neonatal candidiasis were identified. Overall mortality rate was 35%. Virtually every infant had a central venous catheter (CVC, required mechanical ventilation and previous administration of antibacterial agents. Delayed institution of antifungal therapy was associated with increased mortality. In addition, length of hospitalization, duration of prior antibacterial therapy, mechanical ventilation, and CVC use, as well as evidence of end-organ disease, were associated with an adverse outcome. Conclusions. Reliance on available laboratory tools in cases of invasive neonatal candidiasis can result in delayed diagnosis and increased mortality. A risk-factor-based approach to empirical treatment could be justified in this setting.

Nonfragile Robust Model Predictive Control for Uncertain Constrained Systems with Time-Delay Compensation

Directory of Open Access Journals (Sweden)

Wei Jiang

2016-01-01

Full Text Available This study investigates the problem of asymptotic stabilization for a class of discrete-time linear uncertain time-delayed systems with input constraints. Parametric uncertainty is assumed to be structured, and delay is assumed to be known. In Lyapunov stability theory framework, two synthesis schemes of designing nonfragile robust model predictive control (RMPC with time-delay compensation are put forward, where the additive and the multiplicative gain perturbations are, respectively, considered. First, by designing appropriate Lyapunov-Krasovskii (L-K functions, the robust performance index is defined as optimization problems that minimize upper bounds of infinite horizon cost function. Then, to guarantee closed-loop stability, the sufficient conditions for the existence of desired nonfragile RMPC are obtained in terms of linear matrix inequalities (LMIs. Finally, two numerical examples are provided to illustrate the effectiveness of the proposed approaches.

Time Delay Estimation Algoritms for Echo Cancellation

Directory of Open Access Journals (Sweden)

Kirill Sakhnov

2011-01-01

Full Text Available The following case study describes how to eliminate echo in a VoIP network using delay estimation algorithms. It is known that echo with long transmission delays becomes more noticeable to users. Thus, time delay estimation, as a part of echo cancellation, is an important topic during transmission of voice signals over packetswitching telecommunication systems. An echo delay problem associated with IP-based transport networks is discussed in the following text. The paper introduces the comparative study of time delay estimation algorithm, used for estimation of the true time delay between two speech signals. Experimental results of MATLab simulations that describe the performance of several methods based on cross-correlation, normalized crosscorrelation and generalized cross-correlation are also presented in the paper.

Neutron lifetimes behavior analysis considering the two-region kinetic model in the IPEN/MB-01 reactor

Energy Technology Data Exchange (ETDEWEB)

Gonnelli, Eduardo; Diniz, Ricardo [Instituto de Pesquisas Energéticas e Nucleares - IPEN/CNEN-SP Travessa R-400, 05508-900, Cidade Universitária, São Paulo (Brazil)

2014-11-11

This is a complementary work about the behavior analysis of the neutron lifetimes that was developed in the IPEN/MB-01 nuclear reactor facility. The macroscopic neutron noise technique was experimentally employed using pulse mode detectors for two stages of control rods insertion, where a total of twenty levels of subcriticality have been carried out. It was also considered that the neutron reflector density was treated as an additional group of delayed neutrons, being a sophisticated approach in the two-region kinetic theoretical model.

Neutron lifetimes behavior analysis considering the two-region kinetic model in the IPEN/MB-01 reactor

International Nuclear Information System (INIS)

Gonnelli, Eduardo; Diniz, Ricardo

2014-01-01

This is a complementary work about the behavior analysis of the neutron lifetimes that was developed in the IPEN/MB-01 nuclear reactor facility. The macroscopic neutron noise technique was experimentally employed using pulse mode detectors for two stages of control rods insertion, where a total of twenty levels of subcriticality have been carried out. It was also considered that the neutron reflector density was treated as an additional group of delayed neutrons, being a sophisticated approach in the two-region kinetic theoretical model

Delayed growth

Science.gov (United States)

... Slow rate of growth; Retarded growth and development; Growth delay Images Toddler development References Cooke DW, Divall SA, Radovick S. Normal and aberrant growth in children. In: Melmed S, Polonsky KS, Larsen PR, ...

Topology identification of the complex networks with non-delayed and delayed coupling

International Nuclear Information System (INIS)

Guo Wanli; Chen Shihua; Sun Wen

2009-01-01

In practical situation, there exists many uncertain information in complex networks, such as the topological structures. So the topology identification is an important issue in the research of the complex networks. Based on LaSalle's invariance principle, in this Letter, an adaptive controlling method is proposed to identify the topology of a weighted general complex network model with non-delayed and delayed coupling. Finally, simulation results show that the method is effective.

Delay-independent stability of genetic regulatory networks.

Science.gov (United States)

Wu, Fang-Xiang

2011-11-01

Genetic regulatory networks can be described by nonlinear differential equations with time delays. In this paper, we study both locally and globally delay-independent stability of genetic regulatory networks, taking messenger ribonucleic acid alternative splicing into consideration. Based on nonnegative matrix theory, we first develop necessary and sufficient conditions for locally delay-independent stability of genetic regulatory networks with multiple time delays. Compared to the previous results, these conditions are easy to verify. Then we develop sufficient conditions for global delay-independent stability for genetic regulatory networks. Compared to the previous results, this sufficient condition is less conservative. To illustrate theorems developed in this paper, we analyze delay-independent stability of two genetic regulatory networks: a real-life repressilatory network with three genes and three proteins, and a synthetic gene regulatory network with five genes and seven proteins. The simulation results show that the theorems developed in this paper can effectively determine the delay-independent stability of genetic regulatory networks.

Behavioral effects of delayed timeouts from reinforcement.

Science.gov (United States)

Byrne, Tom; Poling, Alan

2017-03-01

Timeouts are sometimes used in applied settings to reduce target responses, and in some circumstances delays are unavoidably imposed between the onset of a timeout and the offset of the response that produces it. The present study examined the effects of signaled and unsignaled timeouts in rats exposed to concurrent fixed-ratio 1 fixed-ratio 1 schedules of food delivery, where each response on one lever, the location of which changed across conditions, produced both food and a delayed 10-s timeout. Delays of 0 to 38 s were examined. Delayed timeouts often, but not always, substantially reduced the number of responses emitted on the lever that produced timeouts relative to the number emitted on the lever that did not produce timeouts. In general, greater sensitivity was observed to delayed timeouts when they were signaled. These results demonstrate that delayed timeouts, like other delayed consequences, can affect behavior, albeit less strongly than immediate consequences. © 2017 Society for the Experimental Analysis of Behavior.

Exponential Antisynchronization Control of Stochastic Memristive Neural Networks with Mixed Time-Varying Delays Based on Novel Delay-Dependent or Delay-Independent Adaptive Controller

Directory of Open Access Journals (Sweden)

Minghui Yu

2017-01-01

Full Text Available The global exponential antisynchronization in mean square of memristive neural networks with stochastic perturbation and mixed time-varying delays is studied in this paper. Then, two kinds of novel delay-dependent and delay-independent adaptive controllers are designed. With the ability of adapting to environment changes, the proposed controllers can modify their behaviors to achieve the best performance. In particular, on the basis of the differential inclusions theory, inequality theory, and stochastic analysis techniques, several sufficient conditions are obtained to guarantee the exponential antisynchronization between the drive system and response system. Furthermore, two numerical simulation examples are provided to the validity of the derived criteria.

The Role of Drugs, Diet, and Food Additives in Hyperactivity.

Science.gov (United States)

Harshbarger, Mary E.

A variety of causes have been suggested for hyperactivity: anoxia and other adverse birth conditions, genetic factors, delayed maturation, maternal smoking and drinking during pregnancy, interaction of temperament and environment, lead poisoning, radiation stress, allergy and food additives, and deprivation of required stimulation. Treatments…

Masculinity, medical mistrust, and preventive health services delays among community-dwelling African-American men.

Science.gov (United States)

Hammond, Wizdom Powell; Matthews, Derrick; Mohottige, Dinushika; Agyemang, Amma; Corbie-Smith, Giselle

2010-12-01

The contribution of masculinity to men's healthcare use has gained increased public health interest; however, few studies have examined this association among African-American men, who delay healthcare more often, define masculinity differently, and report higher levels of medical mistrust than non-Hispanic White men. To examine associations between traditional masculinity norms, medical mistrust, and preventive health services delays. A cross-sectional analysis using data from 610 African-American men age 20 and older recruited primarily from barbershops in the North, South, Midwest, and West regions of the U.S. (2003-2009). Independent variables were endorsement of traditional masculinity norms around self-reliance, salience of traditional masculinity norms, and medical mistrust. Dependent variables were self-reported delays in three preventive health services: routine check-ups, blood pressure screenings, and cholesterol screenings. We controlled for socio-demography, healthcare access, and health status. After final adjustment, men with a greater endorsement of traditional masculinity norms around self-reliance (OR: 0.77; 95% CI: 0.60-0.98) were significantly less likely to delay blood pressure screening. This relationship became non-significant when a longer BP screening delay interval was used. Higher levels of traditional masculinity identity salience were associated with a decreased likelihood of delaying cholesterol screening (OR: 0.62; 95% CI: 0.45-0.86). African-American men with higher medical mistrust were significantly more likely to delay routine check-ups (OR: 2.64; 95% CI: 1.34-5.20), blood pressure (OR: 3.03; 95% CI: 1.45-6.32), and cholesterol screenings (OR: 2.09; 95% CI: 1.03-4.23). Contrary to previous research, higher traditional masculinity is associated with decreased delays in African-American men's blood pressure and cholesterol screening. Routine check-up delays are more attributable to medical mistrust. Building on African-American men

Can Adolescents Learn Self-control? Delay of Gratification in the Development of Control over Risk Taking

Science.gov (United States)

Duckworth, Angela L.; Sznitman, Sharon; Park, Sunhee

2010-01-01

Recent findings from developmental neuroscience suggest that the adolescent brain is too immature to exert control over impulsive drives, such as sensation seeking, that increase during adolescence. Using a discounting of delayed reward paradigm, this research examines the ability to delay gratification as a potential source of control over risk-taking tendencies that increase during adolescence. In addition, it explores the role of experience resulting from risk taking as well as future time perspective as contributors to the development of this ability. In a nationally representative sample (n=900) of young people aged 14–22, a structural equation analysis shows that risk taking as assessed by use of three popular drugs (tobacco, marijuana, and alcohol) is inversely related to the ability to delay gratification. The relation is robust across gender, age, and different levels of sensation seeking. In addition, high sensation seekers exhibit dramatic age-related increase in delay of gratification, lending support to the hypothesis that engaging in risky behavior provides experience that leads to greater patience for long-term rewards. The findings support the conclusion that a complete understanding of the development of self-control must consider individual differences not easily explained by universal trends in brain maturation. PMID:20306298

Risk factors for delay in age-appropriate vaccinations among Gambian children.

Science.gov (United States)

Odutola, Aderonke; Afolabi, Muhammed O; Ogundare, Ezra O; Lowe-Jallow, Yamu Ndow; Worwui, Archibald; Okebe, Joseph; Ota, Martin O

2015-08-28

Vaccination has been shown to reduce mortality and morbidity due to vaccine-preventable diseases. However, these diseases are still responsible for majority of childhood deaths worldwide especially in the developing countries. This may be due to low vaccine coverage or delay in receipt of age-appropriate vaccines. We studied the timeliness of routine vaccinations among children aged 12-59 months attending infant welfare clinics in semi-urban areas of The Gambia, a country with high vaccine coverage. A cross-sectional survey was conducted in four health centres in the Western Region of the Gambia. Vaccination dates were obtained from health cards and timeliness assessed based on the recommended age ranges for BCG (birth-8 weeks), Diphtheria-Pertussis-Tetanus (6 weeks-4 months; 10 weeks-5 months; 14 weeks-6 months) and measles vaccines (38 weeks-12 months). Risk factors for delay in age-appropriate vaccinations were determined using logistic regression. Analysis was limited to BCG, third dose of Diphtheria-Pertussis -Tetanus (DPT3) and measles vaccines. Vaccination records of 1154 children were studied. Overall, 63.3% (95 % CI 60.6-66.1%) of the children had a delay in the recommended time to receiving at least one of the studied vaccines. The proportion of children with delayed vaccinations increased from BCG [5.8% (95 % CI 4.5-7.0%)] to DPT3 [60.4% (95 % CI 57.9%-63.0%)] but was comparatively low for the measles vaccine [10.8% (95 % CI 9.1%-12.5%)]. Mothers of affected children gave reasons for the delay, and their profile correlated with type of occupation, place of birth and mode of transportation to the health facilities. Despite high vaccination coverage reported in The Gambia, a significant proportion of the children's vaccines were delayed for reasons related to health services as well as profile of mothers. These findings are likely to obtain in several countries and should be addressed by programme managers in order to improve and optimize the impact of the

Delayed Esophageal Pseudodiverticulum after Anterior Cervical Spine Fixation: Report of 2 Cases

Directory of Open Access Journals (Sweden)

Ali Sadrizadeh

2015-03-01

Full Text Available Introduction: Although perforation of the esophagus, in the anterior cervical spine fixation, is well established, cases with delayed onset, especially cases that present pseudodiverticulum, are not common. In addition, management of the perforation in this situation is debated.  Case Report:   Delayed esophageal pseudodiverticulum was managed in two patients with a history of anterior spine fixation. Patients were operated on, the loose plate and screws were extracted, the wall of the diverticulum was excised, the perforation on the nasogastric tube was suboptimally repaired, and a closed suction drain was placed there. The NGT was removed on the 7th day and barium swallow demonstrated no leakage at the operation site; therefore, oral feeding was started without any problem.  Conclusion:  In cases with delayed perforation, fistula, or diverticulum removal of anterior fixation instruments, gentle repair of the esophageal wall without persistence on definitive and optimal perforation closure, wide local drainage, early enteral nutrition via NGT, and antibiotic prescription is suggested.

Periodic flows to chaos in time-delay systems

CERN Document Server

Luo, Albert C J

2017-01-01

This book for the first time examines periodic motions to chaos in time-delay systems, which exist extensively in engineering. For a long time, the stability of time-delay systems at equilibrium has been of great interest from the Lyapunov theory-based methods, where one cannot achieve the ideal results. Thus, time-delay discretization in time-delay systems was used for the stability of these systems. In this volume, Dr. Luo presents an accurate method based on the finite Fourier series to determine periodic motions in nonlinear time-delay systems. The stability and bifurcation of periodic motions are determined by the time-delayed system of coefficients in the Fourier series and the method for nonlinear time-delay systems is equivalent to the Laplace transformation method for linear time-delay systems. Facilitates discovery of analytical solutions of nonlinear time-delay systems; Illustrates bifurcation trees of periodic motions to chaos; Helps readers identify motion complexity and singularity; Explains pro...

Delay Variation Model with Two Service Queues

Directory of Open Access Journals (Sweden)

Filip Rezac

2010-01-01

Full Text Available Delay in VoIP technology is very unpleasant issue and therefore a voice packets prioritization must be ensured. To maintain the high call quality a maximum information delivery time from the sender to the recipient is set to 150 ms. This paper focuses on the design of a mathematical model of end-to-end delay of a VoIP connection, in particular on a delay variation. It describes all partial delay components and mechanisms, their generation, facilities and mathematical formulations. A new approach to the delay variation model is presented and its validation has been done by experimention.

Restorative effect of peritoneal macrophages on delayed hypersensitivity following ionizing radiation

International Nuclear Information System (INIS)

Volkman, A.; Collins, F.M.

1971-01-01

Sublethal whole-body irradiation in the guinea pig had little demonstrable effect on the development of delayed hypersensitivity but caused a profound, though transient depression of dermal reactivity in previously sensitized animals. Macrophage-rich peritoneal cell suspensions from non-sensitive donors when injected intradermally with eliciting antigen, resulted in the restoration of a significant degree of reactivity following irradiation. Inocula of lymphocytes, on the other hand, failed to yield similar results. These findings, when taken with the persistence of low levels of reactivity following irradiation and the ability to transfer reactivity with peritoneal exudate cells from animals so treated, warrant the conclusion that the presence of macrophages is necessary for the expression of cutaneous delayed hypersensitivity. The spontaneously renewed activity which follows the depressed phase is thus more of a reflection of the recovery of macrophage precursors from radiation injury, rather than the emergence of a new population of sensitized cells. The results, in addition, substantiate the belief that the expression of delayed hypersensitivity requires at least two cell populations, only one of which carries the property of specificity at the outset

Chaos in the fractional order logistic delay system: Circuit realization and synchronization

International Nuclear Information System (INIS)

Baskonus, Haci Mehmet; Hammouch, Zakia; Mekkaoui, Toufik; Bulut, Hasan

2016-01-01

In this paper, we present a numerical study and a circuit design to prove existence of chaos in the fractional order Logistic delay system. In addition, we investigate an active control synchronization scheme in this system. Numerical and cicruit simulations show the effectiveness and feasibility of this method.

When should we recommend use of dual time-point and delayed time-point imaging techniques in FDG PET?

Energy Technology Data Exchange (ETDEWEB)

Cheng, Gang [Philadelphia VA Medical Center, Department of Radiology, Philadelphia, PA (United States); Hospital of the University of Pennsylvania, Department of Radiology, Philadelphia, PA (United States); Torigian, Drew A.; Alavi, Abass [Hospital of the University of Pennsylvania, Department of Radiology, Philadelphia, PA (United States); Zhuang, Hongming [Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States)

2013-05-15

FDG PET and PET/CT are now widely used in oncological imaging for tumor characterization, staging, restaging, and response evaluation. However, numerous benign etiologies may cause increased FDG uptake indistinguishable from that of malignancy. Multiple studies have shown that dual time-point imaging (DTPI) of FDG PET may be helpful in differentiating malignancy from benign processes. However, exceptions exist, and some studies have demonstrated significant overlap of FDG uptake patterns between benign and malignant lesions on delayed time-point images. In this review, we summarize our experience and opinions on the value of DTPI and delayed time-point imaging in oncology, with a review of the relevant literature. We believe that the major value of DTPI and delayed time-point imaging is the increased sensitivity due to continued clearance of background activity and continued FDG accumulation in malignant lesions, if the same diagnostic criteria (as in the initial standard single time-point imaging) are used. The specificity of DTPI and delayed time-point imaging depends on multiple factors, including the prevalence of malignancies, the patient population, and the cut-off values (either SUV or retention index) used to define a malignancy. Thus, DTPI and delayed time-point imaging would be more useful if performed for evaluation of lesions in regions with significant background activity clearance over time (such as the liver, the spleen, the mediastinum), and if used in the evaluation of the extent of tumor involvement rather than in the characterization of the nature of any specific lesion. Acute infectious and non-infectious inflammatory lesions remain as the major culprit for diminished diagnostic performance of these approaches (especially in tuberculosis-endemic regions). Tumor heterogeneity may also contribute to inconsistent performance of DTPI. The authors believe that selective use of DTPI and delayed time-point imaging will improve diagnostic accuracy and

Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth

DEFF Research Database (Denmark)

Nieminen, Pekka; Morgan, Neil V; Fenwick, Aimée L

2011-01-01

Craniosynostosis and supernumerary teeth most often occur as isolated developmental anomalies, but they are also separately manifested in several malformation syndromes. Here, we describe a human syndrome featuring craniosynostosis, maxillary hypoplasia, delayed tooth eruption, and supernumerary...... teeth. We performed homozygosity mapping in three unrelated consanguineous Pakistani families and localized the syndrome to a region in chromosome 9. Mutational analysis of candidate genes in the region revealed that all affected children harbored homozygous missense mutations (c.662C>G [p.Pro221Arg], c...... for the treatment of craniosynostosis....

Shifted Legendre method with residual error estimation for delay linear Fredholm integro-differential equations

Directory of Open Access Journals (Sweden)

Şuayip Yüzbaşı

2017-03-01

Full Text Available In this paper, we suggest a matrix method for obtaining the approximate solutions of the delay linear Fredholm integro-differential equations with constant coefficients using the shifted Legendre polynomials. The problem is considered with mixed conditions. Using the required matrix operations, the delay linear Fredholm integro-differential equation is transformed into a matrix equation. Additionally, error analysis for the method is presented using the residual function. Illustrative examples are given to demonstrate the efficiency of the method. The results obtained in this study are compared with the known results.

Effects of caffeine on cleavage delay of sea urchin eggs induced by ethidium bromide or puromycin