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Sample records for adaptive hifu noise

  1. Adaptive HIFU noise cancellation for simultaneous therapy and imaging using an integrated HIFU/imaging transducer

    Jeong, Jong Seob; Cannata, Jonathan Matthew; Shung, K Kirk [Department of Biomedical Engineering, NIH Resource Center for Medical Ultrasonic Transducer Technology, University of Southern California, Los Angeles, CA (United States)], E-mail: jongsjeo@usc.edu

    2010-04-07

    It was previously demonstrated that it is feasible to simultaneously perform ultrasound therapy and imaging of a coagulated lesion during treatment with an integrated transducer that is capable of high intensity focused ultrasound (HIFU) and B-mode ultrasound imaging. It was found that coded excitation and fixed notch filtering upon reception could significantly reduce interference caused by the therapeutic transducer. During HIFU sonication, the imaging signal generated with coded excitation and fixed notch filtering had a range side-lobe level of less than -40 dB, while traditional short-pulse excitation and fixed notch filtering produced a range side-lobe level of -20 dB. The shortcoming is, however, that relatively complicated electronics may be needed to utilize coded excitation in an array imaging system. It is for this reason that in this paper an adaptive noise canceling technique is proposed to improve image quality by minimizing not only the therapeutic interference, but also the remnant side-lobe 'ripples' when using the traditional short-pulse excitation. The performance of this technique was verified through simulation and experiments using a prototype integrated HIFU/imaging transducer. Although it is known that the remnant ripples are related to the notch attenuation value of the fixed notch filter, in reality, it is difficult to find the optimal notch attenuation value due to the change in targets or the media resulted from motion or different acoustic properties even during one sonication pulse. In contrast, the proposed adaptive noise canceling technique is capable of optimally minimizing both the therapeutic interference and residual ripples without such constraints. The prototype integrated HIFU/imaging transducer is composed of three rectangular elements. The 6 MHz center element is used for imaging and the outer two identical 4 MHz elements work together to transmit the HIFU beam. Two HIFU elements of 14.4 mm x 20.0 mm dimensions

  2. Adaptive HIFU noise cancellation for simultaneous therapy and imaging using an integrated HIFU/imaging transducer

    It was previously demonstrated that it is feasible to simultaneously perform ultrasound therapy and imaging of a coagulated lesion during treatment with an integrated transducer that is capable of high intensity focused ultrasound (HIFU) and B-mode ultrasound imaging. It was found that coded excitation and fixed notch filtering upon reception could significantly reduce interference caused by the therapeutic transducer. During HIFU sonication, the imaging signal generated with coded excitation and fixed notch filtering had a range side-lobe level of less than -40 dB, while traditional short-pulse excitation and fixed notch filtering produced a range side-lobe level of -20 dB. The shortcoming is, however, that relatively complicated electronics may be needed to utilize coded excitation in an array imaging system. It is for this reason that in this paper an adaptive noise canceling technique is proposed to improve image quality by minimizing not only the therapeutic interference, but also the remnant side-lobe 'ripples' when using the traditional short-pulse excitation. The performance of this technique was verified through simulation and experiments using a prototype integrated HIFU/imaging transducer. Although it is known that the remnant ripples are related to the notch attenuation value of the fixed notch filter, in reality, it is difficult to find the optimal notch attenuation value due to the change in targets or the media resulted from motion or different acoustic properties even during one sonication pulse. In contrast, the proposed adaptive noise canceling technique is capable of optimally minimizing both the therapeutic interference and residual ripples without such constraints. The prototype integrated HIFU/imaging transducer is composed of three rectangular elements. The 6 MHz center element is used for imaging and the outer two identical 4 MHz elements work together to transmit the HIFU beam. Two HIFU elements of 14.4 mm x 20.0 mm dimensions could

  3. Adaptive noise

    Viney, Mark; Reece, Sarah E.

    2013-01-01

    In biology, noise implies error and disorder and is therefore something which organisms may seek to minimize and mitigate against. We argue that such noise can be adaptive. Recent studies have shown that gene expression can be noisy, noise can be genetically controlled, genes and gene networks vary in how noisy they are and noise generates phenotypic differences among genetically identical cells. Such phenotypic differences can have fitness benefits, suggesting that evolution can shape noise ...

  4. Adaptive noise cancellation

    In this report we describe the concept of adaptive noise canceling, an alternative method of estimating signals corrupted by additive noise of interference. The method uses 'primary' input containing the corrupted signal and a 'reference' input containing noise correlated in some unknown way with the primary noise, the reference input is adaptively filtered and subtracted from the primary input to obtain the signal estimate. Adaptive filtering before subtraction allows the treatment of inputs that are deterministic or stochastic, stationary or time variable. When the reference input is free of signal and certain other conditions are met then noise in the primary input can be essentially eliminated without signal distortion. It is further shown that the adaptive filter also acts as notch filter. Simulated results illustrate the usefulness of the adaptive noise canceling technique. (author)

  5. Adaptive Noise Reduction System

    Ivana Ropuš

    2013-01-01

    Full Text Available Noise is an all-present environment pollutant, considered to be one of the greatest contemporary pollutants. World-wide, co-ordinated actions are conducted in order to develop systems which minimise the noise influence onto society.In this article we argue that novel approach to suppression of influence of noise is useful. Furthermore, we argue that the efficient approach is formulation of the efficient, broadly applicable, ubiquituous, adaptive noise-protection system. The approach combines the natural noise-protection form based on plants with the artificially formed coatings.Elements of the system are discussed, its formation and maintenance analysed and perspectives conjectured.

  6. Adaptive noise level estimation

    Yeh, Chunghsin; Roebel, Axel

    2006-01-01

    We describe a novel algorithm for the estimation of the colored noise level in audio signals with mixed noise and sinusoidal components. The noise envelope model is based on the assumptions that the envelope varies slowly with frequency and that the magnitudes of the noise peaks obey a Rayleigh distribution. Our method is an extension of a recently proposed approach of spectral peak classification of sinusoids and noise, which takes into account a noise envelope model to improve the detection...

  7. Adaptive feedback active noise control

    Kuo, Sen M.; Vijayan, Dipa

    Feedforward active noise control (ANC) systems use a reference sensor that senses a reference input to the controller. This signal is assumed to be unaffected by the secondary source and is a good measure of the undesired noise to be cancelled by the system. The reference sensor may be acoustic (e.g., microphone) or non-acoustic (e.g., tachometer, optical transducer). An obvious problem when using acoustic sensors is that the reference signal may be corrupted by the canceling signal generated by the secondary source. This problem is known as acoustic feedback. One way of avoiding this is by using a feedback active noise control (FANC) system which dispenses with the reference sensor. The FANC technique originally proposed by Olson and May employs a high gain negative feedback amplifier. This system suffered from the drawback that the error microphone had to be placed very close to the loudspeaker. The operation of the system was restricted to low frequency range and suffered from instability due to the possibility of positive feedback. Feedback systems employing adaptive filtering techniques for active noise control were developed. This paper presents the FANC system modeled as an adaptive prediction scheme.

  8. Adaptive Noise Suppression Using Digital Signal Processing

    Kozel, David; Nelson, Richard

    1996-01-01

    A signal to noise ratio dependent adaptive spectral subtraction algorithm is developed to eliminate noise from noise corrupted speech signals. The algorithm determines the signal to noise ratio and adjusts the spectral subtraction proportion appropriately. After spectra subtraction low amplitude signals are squelched. A single microphone is used to obtain both eh noise corrupted speech and the average noise estimate. This is done by determining if the frame of data being sampled is a voiced or unvoiced frame. During unvoice frames an estimate of the noise is obtained. A running average of the noise is used to approximate the expected value of the noise. Applications include the emergency egress vehicle and the crawler transporter.

  9. Adaptive Intelligent Ventilation Noise Control Project

    National Aeronautics and Space Administration — To address the NASA need for quiet on-orbit crew quarters (CQ), Physical Optics Corporation (POC) proposes to develop a new Adaptive Intelligent Ventilation Noise...

  10. Adaptive Intelligent Ventilation Noise Control Project

    National Aeronautics and Space Administration — To address NASA needs for quiet crew volumes in a space habitat, Physical Optics Corporation (POC) proposes to develop a new Adaptive Intelligent Ventilation Noise...

  11. Adaptive avoidance of reef noise.

    Stephen D Simpson

    Full Text Available Auditory information is widely used throughout the animal kingdom in both terrestrial and aquatic environments. Some marine species are dependent on reefs for adult survival and reproduction, and are known to use reef noise to guide orientation towards suitable habitat. Many others that forage in food-rich inshore waters would, however, benefit from avoiding the high density of predators resident on reefs, but nothing is known about whether acoustic cues are used in this context. By analysing a sample of nearly 700,000 crustaceans, caught during experimental playbacks in light traps in the Great Barrier Reef lagoon, we demonstrate an auditory capability in a broad suite of previously neglected taxa, and provide the first evidence in any marine organisms that reef noise can act as a deterrent. In contrast to the larvae of species that require reef habitat for future success, which showed an attraction to broadcasted reef noise, taxa with a pelagic or nocturnally emergent lifestyle actively avoided it. Our results suggest that a far greater range of invertebrate taxa than previously thought can respond to acoustic cues, emphasising yet further the potential negative impact of globally increasing levels of underwater anthropogenic noise.

  12. Musical noise reduction using an adaptive filter

    Hanada, Takeshi; Murakami, Takahiro; Ishida, Yoshihisa; Hoya, Tetsuya

    2003-10-01

    This paper presents a method for reducing a particular noise (musical noise). The musical noise is artificially produced by Spectral Subtraction (SS), which is one of the most conventional methods for speech enhancement. The musical noise is the tin-like sound and annoying in human auditory. We know that the duration of the musical noise is considerably short in comparison with that of speech, and that the frequency components of the musical noise are random and isolated. In the ordinary SS-based methods, the musical noise is removed by the post-processing. However, the output of the ordinary post-processing is delayed since the post-processing uses the succeeding frames. In order to improve this problem, we propose a novel method using an adaptive filter. In the proposed system, the observed noisy signal is used as the input signal to the adaptive filter and the output of SS is used as the reference signal. In this paper we exploit the normalized LMS (Least Mean Square) algorithm for the adaptive filter. Simulation results show that the proposed method has improved the intelligibility of the enhanced speech in comparison with the conventional method.

  13. Producing Uniform Lesion Pattern in HIFU Ablation

    Zhou, Yufeng; Kargl, Steven G.; Hwang, Joo Ha

    2009-04-01

    High intensity focused ultrasound (HIFU) is emerging as a modality for treatment of solid tumors. The temperature at the focus can reach over 65° C denaturing cellular proteins resulting in coagulative necrosis. Typically, HIFU parameters are the same for each treated spot in most HIFU control systems. Because of thermal diffusion from nearby spots, the size of lesions will gradually become larger as the HIFU therapy progresses, which may cause insufficient treatment of initial spots, and over-treatment of later ones. It is found that the produced lesion pattern also depends on the scanning pathway. From the viewpoint of the physician creating uniform lesions and minimizing energy exposure are preferred in tumor ablation. An algorithm has been developed to adaptively determine the treatment parameters for every spot in a theoretical model in order to maintain similar lesion size throughout the HIFU therapy. In addition, the exposure energy needed using the traditional raster scanning is compared with those of two other scanning pathways, spiral scanning from the center to the outside and from the outside to the center. The theoretical prediction and proposed algorithm were further evaluated using transparent gel phantoms as a target. Digital images of the lesions were obtained, quantified, and then compared with each other. Altogether, dynamically changing treatment parameters can improve the efficacy and safety of HIFU ablation.

  14. Adaptive noise Wiener filter for scanning electron microscope imaging system.

    Sim, K S; Teh, V; Nia, M E

    2016-03-01

    Noise on scanning electron microscope (SEM) images is studied. Gaussian noise is the most common type of noise in SEM image. We developed a new noise reduction filter based on the Wiener filter. We compared the performance of this new filter namely adaptive noise Wiener (ANW) filter, with four common existing filters as well as average filter, median filter, Gaussian smoothing filter and the Wiener filter. Based on the experiments results the proposed new filter has better performance on different noise variance comparing to the other existing noise removal filters in the experiments. SCANNING 38:148-163, 2016. © 2015 Wiley Periodicals, Inc. PMID:26235517

  15. A new adaptive filtering algorithm for systems with multiplicative noise

    WANG Hui-li; CHEN Xi-xin; LU Qian-hao

    2005-01-01

    Presented here is a new adaptive state filtering algorithm for systems with multiplicative noise. This algorithm estimates the vector state of the system and the statistics of noise when all the statistics of noise are unknown. This filtering algorithm is a simple recursive structure. A simulation example is presented which demonstrates the effectiveness of this filtering algorithm.

  16. Application of Adaptive Filters to Active Noise Control

    PEI Bingnan; LI Chuanguang

    2001-01-01

    A modified LMS algorithm for noise-control is suggested after a mathematical model ofsound-cancellation is established, on the basis of thesound wave interference principle and the physicalmodel of progressive waves in a duct. Its applicationin controlling noise with the frequency range from 100to 800 Hz can be implemented by using the adaptivedigital signal processing technique. The experimentson a pink noise, a broadband noise and a noise takenfrom a tank were made, which show that there existsan attenuation of 11 dB at the frequency of 500 Hzor so, and that the proposed adaptive noise controltechnique is very effective and valid.

  17. SIMULATION AND PERFORMANCE ANALYASIS OF ADAPTIVE FILTER IN NOISE CANCELLATION

    RAJ KUMAR THENUA,

    2010-09-01

    Full Text Available Noise problems in the environment have gained attention due to the tremendous growth of technology that has led to noisy engines, heavy machinery, high speed wind buffeting and other noise sources. The problem of controlling the noise level has become the focus of a tremendous amount of research over the years. In last few years various adaptive algorithms are developed for noise cancellation. In this paper we present an implementation of LMS (Least Mean Square, NLMS (Normalized Least Mean Square and RLS (Recursive Least Square algorithms on MATLAB platform with the intention to compare their performance in noise cancellation. We simulate the adaptive filter in MATLAB with a noisy tone signal and white noise signal and analyze the performance of algorithms in terms of MSE (Mean Squared Error, percentage noise removal, computational complexity and stability. The obtained results shows that RLS has the best performance but at thecost of large computational complexity and memory requirement.

  18. Adaptive Threshold Median Filter for Multiple-Impulse Noise

    JIANG Bo; HUANG Wei

    2007-01-01

    Attenuating the noises plays an essential role in the image processing. Almost all the traditional median filters concern the removal of impulse noise having a single layer, whose noise gray level value is constant. In this paper, a new adaptive median filter is proposed to handle those images corrupted not only by single layer noise. The adaptive threshold median filter(ATMF) has been developed by combining the adaptive median filter (AMF) and two dynamic thresholds. Because of the dynamic threshold being used, the ATMF is able to balance the removal of the multiple-impulse noise and the quality of image. Comparison of the proposed method with traditional median filters is provided. Some visual examples are given to demonstrate the performance of the proposed Filter.

  19. Performance Analysis of LMS Adaptive FIR Filter and RLS Adaptive FIR Filter for Noise Cancellation

    Jyotsna Yadav

    2013-06-01

    Full Text Available Interest in adaptive filters continues to grow as they begin to find practical real-time applications in areas such as channel equalization, echo cancellation, noise cancellation and many other adaptive signal processing applications. The key to successful adaptive signal processing understands the fundamental properties of adaptive algorithms such as LMS, RLS etc. Adaptive filter is used for the cancellation of the noise component which is overlap with undesired signal in the same frequency range. This paper presents design, implementation and performance comparison of adaptive FIR filter using LMS and RMS algorithms. MATLAB Simulink environment are used for simulations.

  20. Adaptive Liners for Broadband Noise Reduction Project

    National Aeronautics and Space Administration — This project will combine the advantages of adaptive materials with the simplistic passive design of state-of-the-art acoustic liners to provide the ability to tune...

  1. Adaptive noise reduction for fiber optic gyroscopes in borehole applications

    Yan, Tingyang; Zhang, Chunxi; Gao, Shuang; Ma, Zongfeng

    2006-11-01

    Fiber Optic Gyroscopes (FOGs) have been investigated and proposed as alternative sensors to magnetometers in borehole surveying applications due to their compactness, ruggedness, low cost and high environmental insensitivity. However, FOGs are subject to high measurement noise from various sources, which deteriorates the performance and quality of FOGs, thus the overall system accuracy is limited. To improve the accuracy of the surveying system, adaptive filtering techniques are utilized to reduce the noise level at the output of the FOG. A Forward Linear Prediction (FLP) filter based on Normalized Least-Mean-Square (NLMS) adaptive algorithm was designed and evaluated using kinematic data. Results show that the FLP filter can suppress the FOG noise to a certain degree and a satisfactory signal-to-noise ratio improvement can be achieved using this method.

  2. An adaptive chaotic secure communication scheme with channel noises

    In this Letter, an adaptive secure communication scheme with channel noises is proposed. Based on the idea of chaotic masking-modulation, the message is encrypted by a chaotic signal. By using adaptive feedback control techniques, the transmitter and the receiver are synchronized, so the masked signal can be perfectly recovered by the receiver in the presence of channel noises. In light of the Lyapunov stability theory for stochastic differential equations, several theoretical results are rigorously established. Finally, the famous Chua's circuits is used to illustrate the possible applications of the obtained theoretical results, and the computer simulations show that the proposed scheme is feasible and efficient

  3. Reduction of Radiographic Quantum Noise Using Adaptive Weighted Median Filter

    Images are easily corrupted by noise during the data transmission, data capture and data processing. A technical method of noise analyzing and adaptive filtering for reducing of quantum noise in radiography is presented. By adjusting the characteristics of the filter according to local statistics around each pixel of the image as moving windowing, it is possible to suppress noise sufficiently while preserve edge and other significant information required in reading. We have proposed adaptive weighted median(AWM) filters based on local statistics. We show two ways of realizing the AWM filters. One is a simple type of AWM filter, whose weights are given by a simple non-linear function of three local characteristics. The other is the AWM filter which is constructed by homogeneous factor(HF). Homogeneous factor(HF) from the quantum noise models that enables the filter to recognize the local structures of the image is introduced, and an algorithm for determining the HF fitted to the detection systems with various inner statistical properties is proposed. We show by the experimented that the performances of proposed method is superior to these of other filters and models in preserving small details and suppressing the noise at homogeneous region. The proposed algorithms were implemented by visual C++ language on a IBM-PC Pentium 550 for testing purposes, the effects and results of the noise filtering were proposed by comparing with images of the other existing filtering methods

  4. Reducing Background Noise Through a Stethoscope Cup Using Adaptive Filters

    Hill, Bryce E.; Christensen, Douglas

    2010-01-01

    An adaptive filtering algorithm was used to test the validity of adaptively filtering respiratory signals recorded at the trachea with an external reference microphone. Two different setups were tested. The first used a microphone in open air, the second used a microphone that was housed inside a second stethoscope cup. The primary microphone was affixed to a phantom material. External sounds and music were played via aloud speaker to record additive noise data from within the stethoscope cup...

  5. Performance Analysis of LMS Adaptive FIR Filter and RLS Adaptive FIR Filter for Noise Cancellation

    Jyotsna Yadav

    2013-07-01

    Full Text Available Interest in adaptive filters continues to grow as they begin to find practical real-time applications in areassuch as channel equalization, echo cancellation, noise cancellation and many other adaptive signalprocessing applications. The key to successful adaptive signal processing understands the fundamentalproperties of adaptive algorithms such as LMS, RLS etc. Adaptive filter is used for the cancellation of thenoise component which is overlap with undesired signal in the same frequency range. This paper presentsdesign, implementation and performance comparison of adaptive FIR filter using LMS and RMSalgorithms. MATLAB Simulink environment are used for simulations.

  6. Noise-exploitation and adaptation in neuromorphic sensors

    Hindo, Thamira; Chakrabartty, Shantanu

    2012-04-01

    Even though current micro-nano fabrication technology has reached integration levels where ultra-sensitive sensors can be fabricated, the sensing performance (resolution per joule) of synthetic systems are still orders of magnitude inferior to those observed in neurobiology. For example, the filiform hairs in crickets operate at fundamental limits of noise; auditory sensors in a parasitoid fly can overcome fundamental limitations to precisely localize ultra-faint acoustic signatures. Even though many of these biological marvels have served as inspiration for different types of neuromorphic sensors, the main focus these designs have been to faithfully replicate the biological functionalities, without considering the constructive role of "noise". In man-made sensors device and sensor noise are typically considered as a nuisance, where as in neurobiology "noise" has been shown to be a computational aid that enables biology to sense and operate at fundamental limits of energy efficiency and performance. In this paper, we describe some of the important noise-exploitation and adaptation principles observed in neurobiology and how they can be systematically used for designing neuromorphic sensors. Our focus will be on two types of noise-exploitation principles, namely, (a) stochastic resonance; and (b) noise-shaping, which are unified within our previously reported framework called Σ▵ learning. As a case-study, we describe the application of Σ▵ learning for the design of a miniature acoustic source localizer whose performance matches that of its biological counterpart(Ormia Ochracea).

  7. MR-guided transcranial brain HIFU in small animal models

    Larrat, B; Pernot, M; Aubry, J-F; Sinkus, R; Fink, M; Tanter, M [Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Universite Paris VII, Laboratoire Ondes et Acoustique, 10 rue Vauquelin, 75 231 Paris Cedex 05 (France); Dervishi, E; Boch, A-L [Hopital de la Pitie-Salpetriere-INSERM, U495, 47 Boulevard de l' Hopital, 75651 Paris Cedex 13 (France); Seilhean, D [Hopital de la Pitie-Salpetriere-Neuropathology Department, 47 Boulevard de l' Hopital, 75651 Paris Cedex 13 (France); Marie, Y [Hopital de la Pitie-Salpetriere-Neurosurgery Department, 47 Boulevard de l' Hopital, 75651 Paris Cedex 13 (France)], E-mail: benoit.larrat@espci.fr

    2010-01-21

    Recent studies have demonstrated the feasibility of transcranial high-intensity focused ultrasound (HIFU) therapy in the brain using adaptive focusing techniques. However, the complexity of the procedures imposes provision of accurate targeting, monitoring and control of this emerging therapeutic modality in order to ensure the safety of the treatment and avoid potential damaging effects of ultrasound on healthy tissues. For these purposes, a complete workflow and setup for HIFU treatment under magnetic resonance (MR) guidance is proposed and implemented in rats. For the first time, tissue displacements induced by the acoustic radiation force are detected in vivo in brain tissues and measured quantitatively using motion-sensitive MR sequences. Such a valuable target control prior to treatment assesses the quality of the focusing pattern in situ and enables us to estimate the acoustic intensity at focus. This MR-acoustic radiation force imaging is then correlated with conventional MR-thermometry sequences which are used to follow the temperature changes during the HIFU therapeutic session. Last, pre- and post-treatment magnetic resonance elastography (MRE) datasets are acquired and evaluated as a new potential way to non-invasively control the stiffness changes due to the presence of thermal necrosis. As a proof of concept, MR-guided HIFU is performed in vitro in turkey breast samples and in vivo in transcranial rat brain experiments. The experiments are conducted using a dedicated MR-compatible HIFU setup in a high-field MRI scanner (7 T). Results obtained on rats confirmed that both the MR localization of the US focal point and the pre- and post-HIFU measurement of the tissue stiffness, together with temperature control during HIFU are feasible and valuable techniques for efficient monitoring of HIFU in the brain. Brain elasticity appears to be more sensitive to the presence of oedema than to tissue necrosis.

  8. MR-guided transcranial brain HIFU in small animal models

    Recent studies have demonstrated the feasibility of transcranial high-intensity focused ultrasound (HIFU) therapy in the brain using adaptive focusing techniques. However, the complexity of the procedures imposes provision of accurate targeting, monitoring and control of this emerging therapeutic modality in order to ensure the safety of the treatment and avoid potential damaging effects of ultrasound on healthy tissues. For these purposes, a complete workflow and setup for HIFU treatment under magnetic resonance (MR) guidance is proposed and implemented in rats. For the first time, tissue displacements induced by the acoustic radiation force are detected in vivo in brain tissues and measured quantitatively using motion-sensitive MR sequences. Such a valuable target control prior to treatment assesses the quality of the focusing pattern in situ and enables us to estimate the acoustic intensity at focus. This MR-acoustic radiation force imaging is then correlated with conventional MR-thermometry sequences which are used to follow the temperature changes during the HIFU therapeutic session. Last, pre- and post-treatment magnetic resonance elastography (MRE) datasets are acquired and evaluated as a new potential way to non-invasively control the stiffness changes due to the presence of thermal necrosis. As a proof of concept, MR-guided HIFU is performed in vitro in turkey breast samples and in vivo in transcranial rat brain experiments. The experiments are conducted using a dedicated MR-compatible HIFU setup in a high-field MRI scanner (7 T). Results obtained on rats confirmed that both the MR localization of the US focal point and the pre- and post-HIFU measurement of the tissue stiffness, together with temperature control during HIFU are feasible and valuable techniques for efficient monitoring of HIFU in the brain. Brain elasticity appears to be more sensitive to the presence of oedema than to tissue necrosis.

  9. Applications of active adaptive noise control to jet engines

    Shoureshi, Rahmat; Brackney, Larry

    1993-01-01

    During phase 2 research on the application of active noise control to jet engines, the development of multiple-input/multiple-output (MIMO) active adaptive noise control algorithms and acoustic/controls models for turbofan engines were considered. Specific goals for this research phase included: (1) implementation of a MIMO adaptive minimum variance active noise controller; and (2) turbofan engine model development. A minimum variance control law for adaptive active noise control has been developed, simulated, and implemented for single-input/single-output (SISO) systems. Since acoustic systems tend to be distributed, multiple sensors, and actuators are more appropriate. As such, the SISO minimum variance controller was extended to the MIMO case. Simulation and experimental results are presented. A state-space model of a simplified gas turbine engine is developed using the bond graph technique. The model retains important system behavior, yet is of low enough order to be useful for controller design. Expansion of the model to include multiple stages and spools is also discussed.

  10. Egg White Phantoms for HIFU

    We used fresh egg white and polyacrylamide to create a transparent tissue mimicking phantom. Heating of phantoms by HIFU leads to egg white protein denaturation and creation of visible white lesions. We measured the acoustical and thermal properties and investigated the possibility to use such phantoms to study the lesion formation during the HIFU therapy

  11. Reduced rank adaptive filtering in impulsive noise environments

    Soury, Hamza

    2014-11-01

    An impulsive noise environment is considered in this paper. A new aspect of signal truncation is deployed to reduce the harmful effect of the impulsive noise to the signal. A full rank direct solution is derived followed by an iterative solution. The reduced rank adaptive filter is presented in this environment by using two methods for rank reduction, while the minimized objective function is defined using the Lp norm. The results are presented and the efficiency of each method is discussed. © 2014 IEEE.

  12. Background Noise Reduction in Wind Tunnels using Adaptive Noise Cancellation and Cepstral Echo Removal Techniques for Microphone Array Applications

    Spalt, Taylor B

    2010-01-01

    Two experiments were conducted to investigate Adaptive Noise Cancelling and Cepstrum echo removal post-processing techniques on acoustic data from a linear microphone array in an anechoic chamber. A point source speaker driven with white noise was used as the primary signal. The first experiment included a background speaker to provide interference noise at three different Signal-to-Noise Ratios to simulate noise propagating down a wind tunnel circuit. The second experiment contained only the...

  13. Nonlinear mode decomposition: A noise-robust, adaptive decomposition method

    Iatsenko, Dmytro; McClintock, Peter V. E.; Stefanovska, Aneta

    2015-09-01

    The signals emanating from complex systems are usually composed of a mixture of different oscillations which, for a reliable analysis, should be separated from each other and from the inevitable background of noise. Here we introduce an adaptive decomposition tool—nonlinear mode decomposition (NMD)—which decomposes a given signal into a set of physically meaningful oscillations for any wave form, simultaneously removing the noise. NMD is based on the powerful combination of time-frequency analysis techniques—which, together with the adaptive choice of their parameters, make it extremely noise robust—and surrogate data tests used to identify interdependent oscillations and to distinguish deterministic from random activity. We illustrate the application of NMD to both simulated and real signals and demonstrate its qualitative and quantitative superiority over other approaches, such as (ensemble) empirical mode decomposition, Karhunen-Loève expansion, and independent component analysis. We point out that NMD is likely to be applicable and useful in many different areas of research, such as geophysics, finance, and the life sciences. The necessary matlab codes for running NMD are freely available for download.

  14. Noise Adaptive Stream Weighting in Audio-Visual Speech Recognition

    Martin Heckmann

    2002-11-01

    Full Text Available It has been shown that integration of acoustic and visual information especially in noisy conditions yields improved speech recognition results. This raises the question of how to weight the two modalities in different noise conditions. Throughout this paper we develop a weighting process adaptive to various background noise situations. In the presented recognition system, audio and video data are combined following a Separate Integration (SI architecture. A hybrid Artificial Neural Network/Hidden Markov Model (ANN/HMM system is used for the experiments. The neural networks were in all cases trained on clean data. Firstly, we evaluate the performance of different weighting schemes in a manually controlled recognition task with different types of noise. Next, we compare different criteria to estimate the reliability of the audio stream. Based on this, a mapping between the measurements and the free parameter of the fusion process is derived and its applicability is demonstrated. Finally, the possibilities and limitations of adaptive weighting are compared and discussed.

  15. An adaptive noise attenuation method for edge and amplitude preservation

    Cai Han-Peng; He Zhen-Hua; Li Ya-Lin; He Guang-Ming; Zou Wen; Zhang Dong-Jun; Liu Pu

    2014-01-01

    Noise intensity distributed in seismic data varies with different frequencies or frequency bands; thus, noise attenuation on the full-frequency band affects the dynamic properties of the seismic reflection signal and the subsequent seismic data interpretation, reservoir description, hydrocarbon detection, etc. Hence, we propose an adaptive noise attenuation method for edge and amplitude preservation, wherein the wavelet packet transform is used to decompose the full-band seismic signal into multiband data and then process these data using nonlinear anisotropic dip-oriented edge-preservingfi ltering. In the fi ltering, the calculated diffusion tensor from the structure tensor can be exploited to establish the direction of smoothing. In addition, the fault confidence measure and discontinuity operator can be used to preserve the structural and stratigraphic discontinuities and edges, and the decorrelation criteria can be used to establish the number of iterations. These parameters can minimize the intervention and subjectivity of the interpreter, and simplify the application of the proposed method. We applied the proposed method to synthetic and real 3D marine seismic data. We found that the proposed method could be used to attenuate noise in seismic data while preserving the effective discontinuity information and amplitude characteristics in seismic refl ection waves, providing high-quality data for interpretation and analysis such as high-resolution processing, attribute analysis, and inversion.

  16. Nonparametric estimation of the volatility under microstructure noise: wavelet adaptation

    Hoffmann, Marc; Schmidt-Hieber, Johannes

    2010-01-01

    We study nonparametric estimation of the volatility function of a diffusion process from discrete data, when the data are blurred by additional noise. This noise can be white or correlated, and serves as a model for microstructure effects in financial modeling, when the data are given on an intra-day scale. By developing pre-averaging techniques combined with wavelet thresholding, we construct adaptive estimators that achieve a nearly optimal rate within a large scale of smoothness constraints of Besov type. Since the underlying signal (the volatility) is genuinely random, we propose a new criterion to assess the quality of estimation; we retrieve the usual minimax theory when this approach is restricted to deterministic volatility.

  17. Simulation and Performance Analysis of Adaptive Filtering Algorithms in Noise Cancellation

    Ferdouse, Lilatul; Nipa, Tamanna Haque; Jaigirdar, Fariha Tasmin

    2011-01-01

    Noise problems in signals have gained huge attention due to the need of noise-free output signal in numerous communication systems. The principal of adaptive noise cancellation is to acquire an estimation of the unwanted interfering signal and subtract it from the corrupted signal. Noise cancellation operation is controlled adaptively with the target of achieving improved signal to noise ratio. This paper concentrates upon the analysis of adaptive noise canceller using Recursive Least Square (RLS), Fast Transversal Recursive Least Square (FTRLS) and Gradient Adaptive Lattice (GAL) algorithms. The performance analysis of the algorithms is done based on convergence behavior, convergence time, correlation coefficients and signal to noise ratio. After comparing all the simulated results we observed that GAL performs the best in noise cancellation in terms of Correlation Coefficient, SNR and Convergence Time. RLS, FTRLS and GAL were never evaluated and compared before on their performance in noise cancellation in ...

  18. Comparative study of adaptive-noise-cancellation algorithms for intrusion detection systems

    Some intrusion detection systems are susceptible to nonstationary noise resulting in frequent nuisance alarms and poor detection when the noise is present. Adaptive inverse filtering for single channel systems and adaptive noise cancellation for two channel systems have both demonstrated good potential in removing correlated noise components prior detection. For such noise susceptible systems the suitability of a noise reduction algorithm must be established in a trade-off study weighing algorithm complexity against performance. The performance characteristics of several distinct classes of algorithms are established through comparative computer studies using real signals. The relative merits of the different algorithms are discussed in the light of the nature of intruder and noise signals

  19. Noise robust automatic speech recognition with adaptive quantile based noise estimation and speech band emphasizing filter bank

    Bonde, Casper Stork; Graversen, Carina; Gregersen, Andreas Gregers;

    2005-01-01

    appearance of the speech signal which require noise robust voice activity detection and assumptions of stationary noise. However, both of these requirements are often not met and it is therefore of particular interest to investigate methods like the Quantile Based Noise Estimation (QBNE) mehtod which......An important topic in Automatic Speech Recognition (ASR) is to reduce the effect of noise, in particular when mismatch exists between the training and application conditions. Many noise robutness schemes within the feature processing domain use as a prerequisite a noise estimate prior to the...... estimates the noise during speech and non-speech sections without the use of a voice activity detector. While the standard QBNE-method uses a fixed pre-defined quantile accross all frequency bands, this paper suggests adaptive QBNE (AQBNE) which adapts the quantile individually to each frequency band...

  20. Emergent Adaptive Noise Reduction from Communal Cooperation of Sensor Grid

    Jones, Kennie H.; Jones, Michael G.; Nark, Douglas M.; Lodding, Kenneth N.

    2010-01-01

    In the last decade, the realization of small, inexpensive, and powerful devices with sensors, computers, and wireless communication has promised the development of massive sized sensor networks with dense deployments over large areas capable of high fidelity situational assessments. However, most management models have been based on centralized control and research has concentrated on methods for passing data from sensor devices to the central controller. Most implementations have been small but, as it is not scalable, this methodology is insufficient for massive deployments. Here, a specific application of a large sensor network for adaptive noise reduction demonstrates a new paradigm where communities of sensor/computer devices assess local conditions and make local decisions from which emerges a global behaviour. This approach obviates many of the problems of centralized control as it is not prone to single point of failure and is more scalable, efficient, robust, and fault tolerant

  1. Adaptive de-noising method based on wavelet and adaptive learning algorithm in on-line PD monitoring

    王立欣; 诸定秋; 蔡惟铮

    2002-01-01

    It is an important step in the online monitoring of partial discharge (PD) to extract PD pulses from various background noises. An adaptive de-noising method is introduced for adaptive noise reduction during detection of PD pulses. This method is based on Wavelet Transform (WT) , and in the wavelet domain the noises decomposed at the levels are reduced by independent thresholds. Instead of the standard hard thresholding function, a new type of hard thresholding function with continuous derivative is employed by this method. For the selection of thresholds, an unsupervised learning algorithm based on gradient in a mean square error (MSE) is present to search for the optimal threshold for noise reduction, and the optimal threshold is selected when the minimum MSE is obtained. With the simulating signals and on-site experimental data processed by this method,it is shown that the background noises such as narrowband noises can be reduced efficiently. Furthermore, it is proved that in comparison with the conventional wavelet de-noising method the adaptive de-noising method has a better performance in keeping the pulses and is more adaptive when suppressing the background noises of PD signals.

  2. A Three-Microphone Adaptive Noise Canceller for Minimizing Reverberation and Signal Distortion

    Zayed M. Ramadan

    2008-01-01

    This paper introduces an adaptive noise canceller (ANC) to improve the system performance in the presence of signal leakage components. The proposed ANC consists of two adaptive filters and three microphones. The first adaptive filter cancels the signal leakage and the second filter cancels the noise. For best results, a least mean squares adaptive algorithm was also introduced and used in the proposed ANC. In this algorithm the step size was based on both error vector and data normalization....

  3. A multi-stage noise adaptive switching filter for extremely corrupted images

    Dinh, Hai; Adhami, Reza; Wang, Yi

    2015-07-01

    A multi-stage noise adaptive switching filter (MSNASF) is proposed for the restoration of images extremely corrupted by impulse and impulse-like noise. The filter consists of two steps: noise detection and noise removal. The proposed extrema-based noise detection scheme utilizes the false contouring effect to get better over detection rate at low noise density. It is adaptive and will detect not only impulse but also impulse-like noise. In the noise removal step, a novel multi-stage filtering scheme is proposed. It replaces corrupted pixel with the nearest uncorrupted median to preserve details. When compared with other methods, MSNASF provides better peak signal to noise ratio (PSNR) and structure similarity index (SSIM). A subjective evaluation carried out online also demonstrates that MSNASF yields higher fidelity.

  4. On-line adaptive line frequency noise cancellation from a nuclear power measuring channel

    Qadir Javed

    2011-01-01

    Full Text Available On-line software for adaptively canceling 50 Hz line frequency noise has been designed and tested at Pakistan Research Reactor 1. Line frequency noise causes much problem in weak signals acquisition. Sometimes this noise is so dominant that original signal is totally corrupted. Although notch filter can be used for eliminating this noise, but if signal of interest is in close vicinity of 50 Hz, then original signal is also attenuated and hence overall performance is degraded. Adaptive noise removal is a technique which could be employed for removing line frequency without degrading the desired signal. In this paper line frequency noise has been eliminated on-line from a nuclear power measuring channel. The adaptive LMS algorithm has been used to cancel 50 Hz noise. The algorithm has been implemented in labVIEW with NI 6024 data acquisition card. The quality of the acquired signal has been improved much as can be seen in experimental results.

  5. Adaptive Feed-Forward Control of Low Frequency Interior Noise

    Kletschkowski, Thomas

    2012-01-01

    This book presents a mechatronic approach to Active Noise Control (ANC). It describes the required elements of system theory, engineering acoustics, electroacoustics and adaptive signal processing in a comprehensive, consistent and systematic manner using a unified notation. Furthermore, it includes a design methodology for ANC-systems, explains its application and describes tools to be used for ANC-system design. From the research point of view, the book presents new approaches to sound source localization in weakly damped interiors. One is based on the inverse finite element method, the other is based on a sound intensity probe with an active free field. Furthermore, a prototype of an ANC-system able to reach the physical limits of local (feed-forward) ANC is described. This is one example for applied research in ANC-system design. Other examples are given for (i) local ANC in a semi-enclosed subspace of an aircraft cargo hold and (ii) for the combination of audio entertainment with ANC.

  6. Performance Evaluation of 2D Adaptive Bilateral Filter For Removal of Noise From Robust Images

    Sridhar, B.; Dr.K.V.V.S.Reddy

    2013-01-01

    In this paper, we present the performance analysis of adaptive bilateral filter by pixel to noise ratio and mean square errors. It was evaluate changing the parameters of the adaptive filter half width values and standard deviations. In adaptive bilateral filter, the edge slope is enhanced by transforming the histogram via a range filter with adaptive offset and width. The variance of range filter can also be adaptive. The filter is applied to improve the sharpens of a gray level and color im...

  7. Noise Estimation from Remote Sensing Images by Fractal Theory and Adaptive Image Block Division

    FU Peng

    2015-11-01

    Full Text Available A novel approach for additive noise estimation from highly textured optical remote sensing images has been proposed, which is based on fractal theory and adaptive image block division. Different from the conventional regular block division based noise estimation methods, the divided adaptive image blocks with the proposed method are adhering to the local image information, which are most likely to be homogeneous blocks. Combining with the week textured image region detection using fractal theory and noise standard deviation calculation using statistical analysis, the proposed method can automatically estimate additive noise intensity from optical remote sensing images. Quantified analysis of experiments with ZY-3 satellite images demonstrates that the proposed method is applicable to optical remote sensing images with various complexities and different noise levels. Meanwhile, the notion of week textured image region detection and adaptive image block division can also be applied to multiplicative noise estimation from radar images after modification.

  8. Adaptive Noise Cancellation Method Used for Wheel Speed Signal of Integrate ABS/ASR System

    MA Yue-feng; LIU Zhao-du; QI Zhi-quan; CUI Hai-feng

    2006-01-01

    A novel adaptive noise cancellation method for wheel speed signal of the anti-lock braking system/anti-slip regulation(ABS/ASR) control system is proposed. Based on the spectrum distribution of vehicle's wheel speed signal got from fast Fourier transform under various conditions, the high-pass filter is used to deal with original wheel speed signals sampled to get reference noise signal and the original wheel speed signals are used as adaptive filter's desired outputs. The difference between original signals and reference noise signals is used as the error signal for the adaptive FIR filter and also used as the whole adaptive noise cancellation system's final output. This method can obtain the noise signal on-line and is easy to use for real control system,which is useful to improve the performance of integrate system ABS/ASR.

  9. HIFU for palliative treatment of pancreatic cancer

    Khokhlova, Tatiana D.; Hwang, Joo Ha

    2011-01-01

    High intensity focused ultrasound (HIFU) is a novel non-invasive modality for ablation of various solid tumors including uterine fibroids, prostate cancer, hepatic, renal, breast and pancreatic tumors. HIFU therapy utilizes mechanical energy in the form of a powerful ultrasound wave that is focused inside the body to induce thermal and/or mechanical effects in tissue. Multiple preclinical and non-randomized clinical trials have been performed to evaluate the safety and efficacy of HIFU for pa...

  10. Adaptive neuro-fuzzy methodology for noise assessment of wind turbine.

    Shahaboddin Shamshirband

    Full Text Available Wind turbine noise is one of the major obstacles for the widespread use of wind energy. Noise tone can greatly increase the annoyance factor and the negative impact on human health. Noise annoyance caused by wind turbines has become an emerging problem in recent years, due to the rapid increase in number of wind turbines, triggered by sustainable energy goals set forward at the national and international level. Up to now, not all aspects of the generation, propagation and perception of wind turbine noise are well understood. For a modern large wind turbine, aerodynamic noise from the blades is generally considered to be the dominant noise source, provided that mechanical noise is adequately eliminated. The sources of aerodynamic noise can be divided into tonal noise, inflow turbulence noise, and airfoil self-noise. Many analytical and experimental acoustical studies performed the wind turbines. Since the wind turbine noise level analyzing by numerical methods or computational fluid dynamics (CFD could be very challenging and time consuming, soft computing techniques are preferred. To estimate noise level of wind turbine, this paper constructed a process which simulates the wind turbine noise levels in regard to wind speed and sound frequency with adaptive neuro-fuzzy inference system (ANFIS. This intelligent estimator is implemented using Matlab/Simulink and the performances are investigated. The simulation results presented in this paper show the effectiveness of the developed method.

  11. Adaptive neuro-fuzzy methodology for noise assessment of wind turbine.

    Shamshirband, Shahaboddin; Petković, Dalibor; Hashim, Roslan; Motamedi, Shervin

    2014-01-01

    Wind turbine noise is one of the major obstacles for the widespread use of wind energy. Noise tone can greatly increase the annoyance factor and the negative impact on human health. Noise annoyance caused by wind turbines has become an emerging problem in recent years, due to the rapid increase in number of wind turbines, triggered by sustainable energy goals set forward at the national and international level. Up to now, not all aspects of the generation, propagation and perception of wind turbine noise are well understood. For a modern large wind turbine, aerodynamic noise from the blades is generally considered to be the dominant noise source, provided that mechanical noise is adequately eliminated. The sources of aerodynamic noise can be divided into tonal noise, inflow turbulence noise, and airfoil self-noise. Many analytical and experimental acoustical studies performed the wind turbines. Since the wind turbine noise level analyzing by numerical methods or computational fluid dynamics (CFD) could be very challenging and time consuming, soft computing techniques are preferred. To estimate noise level of wind turbine, this paper constructed a process which simulates the wind turbine noise levels in regard to wind speed and sound frequency with adaptive neuro-fuzzy inference system (ANFIS). This intelligent estimator is implemented using Matlab/Simulink and the performances are investigated. The simulation results presented in this paper show the effectiveness of the developed method. PMID:25075621

  12. A Three-Microphone Adaptive Noise Canceller for Minimizing Reverberation and Signal Distortion

    Zayed M. Ramadan

    2008-01-01

    Full Text Available This paper introduces an adaptive noise canceller (ANC to improve the system performance in the presence of signal leakage components. The proposed ANC consists of two adaptive filters and three microphones. The first adaptive filter cancels the signal leakage and the second filter cancels the noise. For best results, a least mean squares adaptive algorithm was also introduced and used in the proposed ANC. In this algorithm the step size was based on both error vector and data normalization. Simulation results, carried out using a real speech, demonstrate significant improvements of the proposed ANC over the conventional one in minimizing signal distortion and reverberation.

  13. Shape anomaly detection under strong measurement noise: An analytical approach to adaptive thresholding

    Krasichkov, Alexander S.; Grigoriev, Eugene B.; Bogachev, Mikhail I.; Nifontov, Eugene M.

    2015-10-01

    We suggest an analytical approach to the adaptive thresholding in a shape anomaly detection problem. We find an analytical expression for the distribution of the cosine similarity score between a reference shape and an observational shape hindered by strong measurement noise that depends solely on the noise level and is independent of the particular shape analyzed. The analytical treatment is also confirmed by computer simulations and shows nearly perfect agreement. Using this analytical solution, we suggest an improved shape anomaly detection approach based on adaptive thresholding. We validate the noise robustness of our approach using typical shapes of normal and pathological electrocardiogram cycles hindered by additive white noise. We show explicitly that under high noise levels our approach considerably outperforms the conventional tactic that does not take into account variations in the noise level.

  14. Effects of directional microphone and adaptive multichannel noise reduction algorithm on cochlear implant performance

    Chung, K.; Zeng, F G; Acker, K N

    2006-01-01

    Although cochlear implant (CI) users have enjoyed good speech recognition in quiet, they still have difficulties understanding speech in noise. We conducted three experiments to determine whether a directional microphone and an adaptive multichannel noise reduction algorithm could enhance Cl performance in noise and whether Speech Transmission Index (STI) can be used to predict CI performance in various acoustic and signal processing conditions. In Experiment 1, CI users listened to speech in...

  15. Sequentially Adapted Parallel Feedforward Active Noise Control of Noisy Sinusoidal Signals

    Govind Kannan

    2009-01-01

    Full Text Available A large class of acoustic noise sources has an underlying periodic process that generates a periodic noise component, and thus their acoustic noise can in general be modeled as the sum of a periodic signal and a randomly fluctuating signal (usually a broadband background noise. Active control of periodic noise (i.e., for a mixture of sinusoids is more effective than that of random noise. For mixtures of sinusoids in a background broadband random noise, conventional FXLMS-based single filter method does not reach the maximum achievable Noise Attenuation Level (NALmax⁡. In this paper, an alternative approach is taken and the idea of a parallel active noise control (ANC architecture for cancelling mixtures of periodic and random signals is presented. The proposed ANC system separates the noise into periodic and random components and generates corresponding antinoises via separate noise cancelling filters, and tends to reach NALmax⁡ consistently. The derivation of NALmax⁡ is presented. Both the separation and noise cancellation are based on adaptive filtering. Experimental results verify the analytical development by showing superior performance of the proposed method, over the single-filter approach, for several cases of sinusoids in white noise.

  16. Time-shared channel identification for adaptive noise cancellation in breath sound extraction

    Zheng HAN; Hong WANG; Leyi WANG; Gang George YIN

    2004-01-01

    Noise artifacts are one of the key obstacles in applying continuous monitoring and computer-assisted analysis of lung sounds.Traditional adaptive noise cancellation (ANC) methodologies work reasonably well when signal and noise are stationary and independent.Clinical lung sound auscultation encounters an acoustic environment in which breath sounds are not stationary and often correlate with noise.Consequently,capability of ANC becomes significantly compromised.This paper introduces a new methodology for extracting authentic lung sounds from noise-corrupted measurements.Unlike traditional noise cancellation methods that rely on either frequency band separation or signal/noise independence to achieve noise reduction,this methodology combines the traditional noise canceling methods with the unique feature of time-split stages in breathing sounds.By employing a multi-sensor system,the method first employs a high-pass filter to eliminate the off-band noise,and then performs time-shared blind identification and noise cancellation with recursion from breathing cycle to cycle.Since no frequency separation or signal/noise independence is required,this method potentially has a robust and reliable capability of noise reduction,complementing the traditional methods.

  17. Stabilization of the distribution of the product output in adaptive receivers noise signal

    Yu. L. Mazor

    1986-04-01

    Full Text Available The algorithm of adaptive receiving noise signals on the background noise interference with monotonically varying spectra, allowing through the introduction of a reference path to stabilize the distribution of the output product. With the help of computer modeling an estimate of the effectiveness of the proposed algorithm.

  18. Adaptive noise estimation and suppression for improving microseismic event detection

    Mousavi, S. Mostafa; Langston, Charles A.

    2016-09-01

    Microseismic data recorded by surface arrays are often strongly contaminated by unwanted noise. This background noise makes the detection of small magnitude events difficult. A noise level estimation and noise reduction algorithm is presented for microseismic data analysis based upon minimally controlled recursive averaging and neighborhood shrinkage estimators. The method might not be compared with more sophisticated and computationally expensive denoising algorithm in terms of preserving detailed features of seismic signal. However, it is fast and data-driven and can be applied in real-time processing of continuous data for event detection purposes. Results from application of this algorithm to synthetic and real seismic data show that it holds a great promise for improving microseismic event detection.

  19. Adaptive Drainage Slots for Acoustic Noise Attenuation Project

    National Aeronautics and Space Administration — Cornerstone Research Group, Inc. (CRG), proposes to demonstrate feasibility in the reduction of noise attributed to drainage slots in jet engine acoustic liners....

  20. Adaptive Drainage Slots for Acoustic Noise Attenuation Project

    National Aeronautics and Space Administration — Cornerstone Research Group, Inc. (CRG) demonstrated feasibility in the reduction of noise attributed to drainage slots in jet engine acoustic liners. This was...

  1. Multi-channel differencing adaptive noise cancellation with multi-kernel method

    Wei Gao; Jianguo Huang; Jing Han

    2015-01-01

    Although a various of existing techniques are able to improve the performance of detection of the weak interesting sig-nal, how to adaptively and efficiently attenuate the intricate noises especial y in the case of no available reference noise signal is stil the bottleneck to be overcome. According to the characteristics of sonar arrays, a multi-channel differencing method is presented to provide the prerequisite reference noise. However, the ingre-dient of obtained reference noise is too complicated to be used to effectively reduce the interference noise only using the clas-sical linear cancel ation methods. Hence, a novel adaptive noise cancel ation method based on the multi-kernel normalized least-mean-square algorithm consisting of weighted linear and Gaussian kernel functions is proposed, which al ows to simultaneously con-sider the cancel ation of linear and nonlinear components in the reference noise. The simulation results demonstrate that the out-put signal-to-noise ratio (SNR) of the novel multi-kernel adaptive filtering method outperforms the conventional linear normalized least-mean-square method and the mono-kernel normalized least-mean-square method using the realistic noise data measured in the lake experiment.

  2. Solution for Vehicles Noise Cancellation With Modification of LMS Adaptive Algorithm

    Sri Arttini Dwi Prasetyowati

    2012-05-01

    Full Text Available The problems of noise cancelling systems are based on the specific characteristics of their sources. Therefore, the knowledge of each noise source should be represented prior to the excecution ofthe designed noise cancelling scheme. Since the noises emitted vary with the types of the passing vehicles, the scheme should be well adjusted automatically. The delay must be minimixed by managing the value of step size. Five representing types of noise producing vehicles (noise from: bus, truck, motocycle, car with diesel fuel, and car with gasoline were always changing following the passing vehicle. The robust LMS (Least Mean Square algorithm was applied first, then followed by modification LMS algorithm. The results show that LMS algorithm with two process, which is modification from adaptive LMS algorithm is the simplest and the best if it is applied in vehicle’s noise cancellation.

  3. PSO Algorithm based Adaptive Median Filter for Noise Removal in Image Processing Application

    Ruby Verma

    2016-07-01

    Full Text Available A adaptive Switching median filter for salt and pepper noise removal based on genetic algorithm is presented. Proposed filter consist of two stages, a noise detector stage and a noise filtering stage. Particle swarm optimization seems to be effective for single objective problem. Noise Dictation stage works on it. In contrast to the standard median filter, the proposed algorithm generates the noise map of corrupted Image. Noise map gives information about the corrupted and non-corrupted pixels of Image. In filtering, filter calculates the median of uncorrupted neighbouring pixels and replaces the corrupted pixels. Extensive simulations are performed to validate the proposed filter. Simulated results show refinement both in Peak signal to noise ratio (PSNR and Image Quality Index value (IQI. Experimental results shown that proposed method is more effective than existing methods.

  4. Adaptive nonlocal means filtering based on local noise level for CT denoising

    Purpose: To develop and evaluate an image-domain noise reduction method based on a modified nonlocal means (NLM) algorithm that is adaptive to local noise level of CT images and to implement this method in a time frame consistent with clinical workflow. Methods: A computationally efficient technique for local noise estimation directly from CT images was developed. A forward projection, based on a 2D fan-beam approximation, was used to generate the projection data, with a noise model incorporating the effects of the bowtie filter and automatic exposure control. The noise propagation from projection data to images was analytically derived. The analytical noise map was validated using repeated scans of a phantom. A 3D NLM denoising algorithm was modified to adapt its denoising strength locally based on this noise map. The performance of this adaptive NLM filter was evaluated in phantom studies in terms of in-plane and cross-plane high-contrast spatial resolution, noise power spectrum (NPS), subjective low-contrast spatial resolution using the American College of Radiology (ACR) accreditation phantom, and objective low-contrast spatial resolution using a channelized Hotelling model observer (CHO). Graphical processing units (GPU) implementation of this noise map calculation and the adaptive NLM filtering were developed to meet demands of clinical workflow. Adaptive NLM was piloted on lower dose scans in clinical practice. Results: The local noise level estimation matches the noise distribution determined from multiple repetitive scans of a phantom, demonstrated by small variations in the ratio map between the analytical noise map and the one calculated from repeated scans. The phantom studies demonstrated that the adaptive NLM filter can reduce noise substantially without degrading the high-contrast spatial resolution, as illustrated by modulation transfer function and slice sensitivity profile results. The NPS results show that adaptive NLM denoising preserves the

  5. Adaptive nonlocal means filtering based on local noise level for CT denoising

    Li, Zhoubo; Trzasko, Joshua D.; Lake, David S.; Blezek, Daniel J.; Manduca, Armando, E-mail: manduca.armando@mayo.edu [Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota 55905 (United States); Yu, Lifeng; Fletcher, Joel G.; McCollough, Cynthia H. [Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905 (United States)

    2014-01-15

    Purpose: To develop and evaluate an image-domain noise reduction method based on a modified nonlocal means (NLM) algorithm that is adaptive to local noise level of CT images and to implement this method in a time frame consistent with clinical workflow. Methods: A computationally efficient technique for local noise estimation directly from CT images was developed. A forward projection, based on a 2D fan-beam approximation, was used to generate the projection data, with a noise model incorporating the effects of the bowtie filter and automatic exposure control. The noise propagation from projection data to images was analytically derived. The analytical noise map was validated using repeated scans of a phantom. A 3D NLM denoising algorithm was modified to adapt its denoising strength locally based on this noise map. The performance of this adaptive NLM filter was evaluated in phantom studies in terms of in-plane and cross-plane high-contrast spatial resolution, noise power spectrum (NPS), subjective low-contrast spatial resolution using the American College of Radiology (ACR) accreditation phantom, and objective low-contrast spatial resolution using a channelized Hotelling model observer (CHO). Graphical processing units (GPU) implementation of this noise map calculation and the adaptive NLM filtering were developed to meet demands of clinical workflow. Adaptive NLM was piloted on lower dose scans in clinical practice. Results: The local noise level estimation matches the noise distribution determined from multiple repetitive scans of a phantom, demonstrated by small variations in the ratio map between the analytical noise map and the one calculated from repeated scans. The phantom studies demonstrated that the adaptive NLM filter can reduce noise substantially without degrading the high-contrast spatial resolution, as illustrated by modulation transfer function and slice sensitivity profile results. The NPS results show that adaptive NLM denoising preserves the

  6. Micro-bubble enhanced HIFU

    Kajiyama, K.; Yoshinaka, K.; Takagi, S.; Matsumoto, Y.

    2010-01-01

    High intensity focused ultrasound (HIFU) treatment that employs microbubbles to provide enhanced heating has been investigated in order to develop a less invasive and more rapid tumor ablation therapy. It has been demonstrated that microbubbles have significant effects on heating enhancement in vitro and in vivo experiments, however ultrasound propagation could be disturbed when there are too many microbubbles between the transducer and the focus. In this study, we develop a method to make a clear pass way for obtaining enhanced heating by using microbubbles just at the focus, thus avoiding heating on the pass way from the transducer to the target region. In this method, microbubbles are destroyed in front of the HIFU focus (on the transducer side) by irradiating a intense burst wave of microsecond order, before irradiating the ultrasound waves for heating the target region. The experiment is conducted in a medium of a polyacrylamide gel containing microbubbles, and a temperature-sensing liquid crystal sheet is set in the focus to observe the temperature distribution. The ultrasound frequency was 2.2 MHz and the intensity was 5000 W/cm2, and 20 burst waves were irradiated at pulse repetition frequency of 1 kHz. The number of wave pulses was varied. The continuous-wave frequency, intensity and irradiation time are 2.2 MHz, 1000 W/cm2 and 60 sec, respectively. As the number of pulses increased, the heating region moves from the transducer side to the focus. This is because microbubbles in front of the focus are destroyed and the ultrasound propagates around the target position effectively. These results suggest that the microbubble distribution and the heating position in the developed HIFU system can be controlled.

  7. Periodic Noise Suppression from ECG Signal using Novel Adaptive Filtering Techniques

    Yogesh Sharma

    2012-03-01

    Full Text Available Electrocardiogram signal most commonly known recognized and used biomedical signal for medical examination of heart. The ECG signal is very sensitive in nature, and even if small noise mixed with original signal, the various characteristics of the signal changes, Data corrupted with noise must either filtered or discarded, filtering is important issue for design consideration of real time heart monitoring systems. Various filters used for removing the noise from ECG signals, most commonly used filters are Notch Filters, FIR filters, IIR filters, Wiener filter, Adaptive filters etc. Performance analysis shows that the best result is obtained by using Adaptive filter to remove various noises from ECG signal and get significant SNR andMSE results. In this paper a novel adaptive approach by using LMS algorithm and delay has shown whichcan be used for pre-processing of ECG signal and give appreciable result.

  8. A NEW DE-NOISING METHOD BASED ON 3-BAND WAVELET AND NONPARAMETRIC ADAPTIVE ESTIMATION

    Li Li; Peng Yuhua; Yang Mingqiang; Xue Peijun

    2007-01-01

    Wavelet de-noising has been well known as an important method of signal de-noising.Recently,most of the research efforts about wavelet de-noising focus on how to select the threshold,where Donoho method is applied widely.Compared with traditional 2-band wavelet,3-band wavelet has advantages in many aspects.According to this theory,an adaptive signal de-noising method in 3-band wavelet domain based on nonparametric adaptive estimation is proposed.The experimental results show that in 3-band wavelet domain,the proposed method represents better characteristics than Donoho method in protecting detail and improving the signal-to-noise ratio of reconstruction signal.

  9. Direction-Based Adaptive Switching Filter for Removing High-Density Impulse Noise

    刘会刚; 孙菁; 张福海; 任立儒

    2014-01-01

    A direction-based adaptive switching (DBAS) filter is presented for the removal of high-density impulse noise in images. The extrema detection and 28-directional detection are employed to discriminate the pixels as noisy or noise-free. If a pixel is classified as noisy, it will be replaced by a median or a mean value within an adaptive filter window with respect to different noise densities. Simulation results show that the miss-detection ratio and false-alarm ratio are both very low even at noise level as high as 90%. At the same time, better results are obtained in terms of the qualitative and quantitative measures. The peak signal-to-noise ratios increase by nearly 1 dB compared with other existing algorithms. In addition, the computation time is around 10 s for test images with resolutions of 512´512 since the proposed approach has low complexity.

  10. Construction and solution of an adaptive image-restoration model for removing blur and mixed noise

    Wang, Youquan; Cui, Lihong; Cen, Yigang; Sun, Jianjun

    2016-03-01

    We establish a practical regularized least-squares model with adaptive regularization for dealing with blur and mixed noise in images. This model has some advantages, such as good adaptability for edge restoration and noise suppression due to the application of a priori spatial information obtained from a polluted image. We further focus on finding an important feature of image restoration using an adaptive restoration model with different regularization parameters in polluted images. A more important observation is that the gradient of an image varies regularly from one regularization parameter to another under certain conditions. Then, a modified graduated nonconvexity approach combined with a median filter version of a spatial information indicator is proposed to seek the solution of our adaptive image-restoration model by applying variable splitting and weighted penalty techniques. Numerical experiments show that the method is robust and effective for dealing with various blur and mixed noise levels in images.

  11. Emerging HIFU applications in cancer therapy.

    Maloney, Ezekiel; Hwang, Joo Ha

    2015-05-01

    High intensity focused ultrasound (HIFU), is a promising, non-invasive modality for treatment of tumours in conjunction with magnetic resonance imaging or diagnostic ultrasound guidance. HIFU is being used increasingly for treatment of prostate cancer and uterine fibroids. Over the last 10 years a growing number of clinical trials have examined HIFU treatment of both benign and malignant tumours of the liver, breast, pancreas, bone, connective tissue, thyroid, parathyroid, kidney and brain. For some of these emerging indications, HIFU is poised to become a serious alternative or adjunct to current standard treatments--including surgery, radiation, gene therapy, immunotherapy, and chemotherapy. Current commercially available HIFU devices are marketed for their thermal ablation applications. In the future, lower energy treatments may play a significant role in mediating targeted drug and gene delivery for cancer treatment. In this article we introduce currently available HIFU systems, provide an overview of clinical trials in emerging oncological targets, and briefly discuss selected pre-clinical research that is relevant to future oncological HIFU applications. PMID:25367011

  12. Effects of MRTI sampling characteristics on estimation of HIFU SAR and tissue thermal diffusivity

    Dillon, C. R.; Todd, N.; Payne, A.; Parker, D. L.; Christensen, D. A.; Roemer, R. B.

    2013-10-01

    While the non-invasive and three-dimensional nature of magnetic-resonance temperature imaging (MRTI) makes it a valuable tool for high-intensity focused ultrasound (HIFU) treatments, random and systematic errors in MRTI measurements may propagate into temperature-based parameter estimates used for pretreatment planning. This study assesses the MRTI effects of zero-mean Gaussian noise (SD = 0.0-2.0 °C), temporal sampling (tacq = 1.0-8.0 s), and spatial averaging (Res = 0.5-2.0 mm isotropic) on HIFU temperature measurements and temperature-based estimates of the amplitude and full width half maximum (FWHM) of the HIFU specific absorption rate and of tissue thermal diffusivity. The ultrasound beam used in simulations and ex vivo pork loin experiments has lateral and axial FWHM dimensions of 1.4 mm and 7.9 mm respectively. For spatial averaging simulations, beams with lateral FWHM varying from 1.2-2.2 mm are also assessed. Under noisy conditions, parameter estimates are improved by fitting to data from larger voxel regions. Varying the temporal sampling results in minimal changes in measured temperatures (HIFU beams studied, a spatial resolution of 1 × 1 × 3 mm3 or smaller is required to keep errors in temperature and all estimated parameters less than 10%. By quantifying the errors associated with these sampling characteristics, this work provides researchers with appropriate MRTI conditions for obtaining estimates of parameters essential to pretreatment modeling of HIFU thermal therapies.

  13. Object detection in ultrasound elastography for use in HIFU treatment of cancer

    Huang, Alex; Mankani, Soumya; Choo, Chang

    2014-03-01

    High intensity focused ultrasound (HIFU), has applications in treating various cancers, such as prostate, liver and breast cancer. In order for HIFU to be effective and efficient it needs to be guided by an imaging modality. While there are several options for guiding HIFU treatment, one of the most promising is ultrasound elastography. Current commercial devices use Brightness-Mode (B-mode) imaging or MRI, and are manual processes. Ultrasound elastography, allows complete automation of HIFU treatment due to the enhanced image, that elastography provides. The elastic image provides more information and less noise. To show that segmentation was possible on elastic images, nine algorithms were implemented in matlab and used on three distinct images for object detection. The three images used, have varying properties regarding object intensity and placement, as well as different noise patterns. Using PSNR, to gauge the effectiveness of each algorithm, it was shown that segmentation was possible on all images using different algorithms. The bilateral-shock-bilateral algorithm proved to be an overall effective algorithm in every situation with a PSNR of 83.87db on the phantom image. The segmentation results clearly highlight any object in the images. Future work includes fine tuning the algorithm with different phantom images and in-vivo images to distinguish between noise and desired object.

  14. Channel Impulse Response Length and Noise Variance Estimation for OFDM Systems with Adaptive Guard Interval

    Van Duc Nguyen

    2007-02-01

    Full Text Available A new algorithm estimating channel impulse response (CIR length and noise variance for orthogonal frequency-division multiplexing (OFDM systems with adaptive guard interval (GI length is proposed. To estimate the CIR length and the noise variance, the different statistical characteristics of the additive noise and the mobile radio channels are exploited. This difference is due to the fact that the variance of the channel coefficients depends on the position within the CIR, whereas the noise variance of each estimated channel tap is equal. Moreover, the channel can vary rapidly, but its length changes more slowly than its coefficients. An auxiliary function is established to distinguish these characteristics. The CIR length and the noise variance are estimated by varying the parameters of this function. The proposed method provides reliable information of the estimated CIR length and the noise variance even at signal-to-noise ratio (SNR of 0 dB. This information can be applied to an OFDM system with adaptive GI length, where the length of the GI is adapted to the current length of the CIR. The length of the GI can therefore be optimized. Consequently, the spectral efficiency of the system is increased.

  15. Channel Impulse Response Length and Noise Variance Estimation for OFDM Systems with Adaptive Guard Interval

    Gelle Guillaume

    2007-01-01

    Full Text Available A new algorithm estimating channel impulse response (CIR length and noise variance for orthogonal frequency-division multiplexing (OFDM systems with adaptive guard interval (GI length is proposed. To estimate the CIR length and the noise variance, the different statistical characteristics of the additive noise and the mobile radio channels are exploited. This difference is due to the fact that the variance of the channel coefficients depends on the position within the CIR, whereas the noise variance of each estimated channel tap is equal. Moreover, the channel can vary rapidly, but its length changes more slowly than its coefficients. An auxiliary function is established to distinguish these characteristics. The CIR length and the noise variance are estimated by varying the parameters of this function. The proposed method provides reliable information of the estimated CIR length and the noise variance even at signal-to-noise ratio (SNR of 0 dB. This information can be applied to an OFDM system with adaptive GI length, where the length of the GI is adapted to the current length of the CIR. The length of the GI can therefore be optimized. Consequently, the spectral efficiency of the system is increased.

  16. A New Adaptive Square-Root Unscented Kalman Filter for Nonlinear Systems with Additive Noise

    Yong Zhou

    2015-01-01

    Full Text Available The Kalman filter (KF, extended KF, and unscented KF all lack a self-adaptive capacity to deal with system noise. This paper describes a new adaptive filtering approach for nonlinear systems with additive noise. Based on the square-root unscented KF (SRUKF, traditional Maybeck’s estimator is modified and extended to nonlinear systems. The square root of the process noise covariance matrix Q or that of the measurement noise covariance matrix R is estimated straightforwardly. Because positive semidefiniteness of Q or R is guaranteed, several shortcomings of traditional Maybeck’s algorithm are overcome. Thus, the stability and accuracy of the filter are greatly improved. In addition, based on three different nonlinear systems, a new adaptive filtering technique is described in detail. Specifically, simulation results are presented, where the new filter was applied to a highly nonlinear model (i.e., the univariate nonstationary growth model (UNGM. The UNGM is compared with the standard SRUKF to demonstrate its superior filtering performance. The adaptive SRUKF (ASRUKF algorithm can complete direct recursion and calculate the square roots of the variance matrixes of the system state and noise, which ensures the symmetry and nonnegative definiteness of the matrixes and greatly improves the accuracy, stability, and self-adaptability of the filter.

  17. Development of a High Intensity Focused Ultrasound (HIFU) Hydrophone System

    The growing clinical use of High Intensity Focused Ultrasound (HIFU) has driven a need for reliable, reproducible measurements of HIFU acoustic fields. We have previously presented data on a reflective scatterer approach, incorporating several novel features for improved bandwidth, reliability, and reproducibility [Proc. 2005 IEEE Ultrasonics Symposium, 1739-1742]. We now report on several design improvements which have increase the signal to noise ratio of the system, and potentially reduced the cost of implementation. For the scattering element, we now use an artificial sapphire material to provide a more uniform radiating surface. The receiver is a segmented, truncated spherical structure with a 10 cm radius; the scattering element is positioned at the center of the sphere. The receiver is made from 25 micron thick, biaxially stretched PVDF, with a Pt-Au electrode on the front surface. In the new design, a specialized backing material provides the stiffness required to maintain structural stability, while at the same time providing both electrical shielding and ultrasonic absorption. Compared with the previous version, the new receiver design has improved the noise performance by 8-12 dB; the new scattering sphere has reduced the scattering loss by another 14 dB, producing an effective sensitivity of -298 dB re 1 microVolt/Pa. The design trade-off still involves receiver sensitivity with effective spot size, and signal distortion from the scatter structure. However, the reduced cost and improved repeatability of the new scatter approach makes the overall design more robust for routine waveform measurements of HIFU systems.

  18. Implementasi dan Perbandingan Metode Alpha-Trimmed Mean Filter dan Adaptive Media Filter untuk Reduksi Noise pada Citra Digital

    Nababan, Sunfirst Lady Jeanfera

    2015-01-01

    Basically, every image acquisition can cause to the presence of noise in the resulting image. Uniform Noise, Salt & Pepper Noise, and Speckle Noise are three of many model noises that are present in the image. Digital image that contained noise can cause problems in the form of an image that cannot be interpreted properly by human, however noise can be reduce through image restoration called filtering. Filter method that can be used to reduce the noises are Alpha-Trimmed Mean Filter and Adapt...

  19. HIFU for Palliative Treatment of Pancreatic Cancer.

    Khokhlova, Tatiana D; Hwang, Joo Ha

    2016-01-01

    Pancreatic cancer is one of the deadliest malignancies, with only a 6 % 5-year survival rate and over 50 % of patients being diagnosed at the advanced stage. Current therapies are ineffective, and the treatment of patients with advanced disease is palliative. In the past decade, HIFU ablation has emerged as a modality for palliative treatment of pancreatic tumors. Multiple preclinical and non-randomized clinical trials have been performed to evaluate the safety and efficacy of this procedure. Substantial tumor-related pain reduction was achieved in most cases after HIFU treatment and few significant side effects were observed. In addition, some studies indicate that combination of HIFU ablation with chemotherapy may provide a survival benefit. This chapter summarizes the pre-clinical and clinical experience obtained to date in HIFU treatment of pancreatic tumors and discusses the challenges, limitations and new approaches in this modality. PMID:26486333

  20. Design of a Low-Power VLSI Macrocell for Nonlinear Adaptive Video Noise Reduction

    Fanucci Luca; Saponara Sergio; Terreni Pierangelo

    2004-01-01

    A VLSI macrocell for edge-preserving video noise reduction is proposed in the paper. It is based on a nonlinear rational filter enhanced by a noise estimator for blind and dynamic adaptation of the filtering parameters to the input signal statistics. The VLSI filter features a modular architecture allowing the extension of both mask size and filtering directions. Both spatial and spatiotemporal algorithms are supported. Simulation results with monochrome test videos prove its efficiency for ...

  1. Real-time adaptive filtering of dental drill noise using a digital signal processor

    Kaymak, E; Atherton, MA; Rotter, KRG; Millar, B.

    2006-01-01

    The application of noise reduction methods requires the integration of acoustics engineering and digital signal processing, which is well served by a mechatronic approach as described in this paper. The Normalised Least Mean Square (NLMS) algorithm is implemented on the Texas Instruments TMS320C6713 DSK Digital Signal Processor (DSP) as an adaptive digital filter for dental drill noise. Blocks within the Matlab/Simulink Signal Processing Blockset and the Embedded Target for TI C6000 DSP famil...

  2. Determination of cytotoxic thermal dose during HIFU ablation

    Nandlall, Sacha D.; Bazán-Peregrino, Miriam; Mo, Steven; Coussios, Constantin-C.

    2012-10-01

    Thermal dose has been proposed for various hyperthermic cancer treatment modalities as a measure of heat-induced cell and tissue damage. However, many of the models that are currently used for calculating thermal dose have not been validated or suitably adapted for the elevated temperatures and rates of heating encountered during ablation by High-Intensity Focused Ultrasound (HIFU). This work quantifies the performance of the widely employed Cumulative Equivalent Minutes at 43°C (CEM43) thermal dose metric under HIFU-relevant heating. A total of 36 agar phantoms were embedded with different human cancer cell lines (PC3, 22RV1, or ZR75.1) as well as calcein AM and propidium iodide assays. The phantoms were cast in sterile molds with internal dimensions of 7 cm × 7 cm × 2 mm. Using a water bath, 12 of the phantoms were treated with mild hyperthermia (43-46°C for up to 60 minutes), while another 12 were subjected to HIFU-relevant temperature profiles (60-80°C peak temperature, 2-3°C/s peak heating rate). In each of the remaining 12 phantoms, 8 HIFU exposures were carried out in a 37°C water tank (1.067 MHz, 95% duty cycle, 3-6 MPa peak rarefaction pressure, 2-20 s exposure duration). Cavitation emissions were monitored passively with a detector transducer that was confocally and co-axially aligned with the HIFU source. Cell death was quantified by measuring the locally averaged fluorescence intensity of the assays relative to unheated and severely heat-shocked phantoms. The results show that the CEM43 dose required to achieve the same level of heat-induced cell death varies considerably across cell lines, and that inertial cavitation can cause significant mechanical damage at ablation-relevant intensities even when no significant thermal dose is delivered (CEM43 < 5 s). These findings demonstrate the need for improved models of cell death at ablation-relevant temperatures.

  3. Removal of noises from electromagnetic radiation of coal or rock with EEMD-adaptive morphological filter

    CHEN Shi-hai; WANG En-yuan

    2012-01-01

    The electromagnetic radiation (EMR) signal collected by monitoring system during coal or rock dynamic disaster may be interferred easily by electromagnetic noises in mines.The noises have a direct influence on the recognition and analysis of the EMR signal features during the disaster.With the aim of removing these noises,an ensemble empirical mode decomposition (EEMD) adaptive morphological filter was proposed.From the result of the simulation and the experiment,it is shown that the method can restrain the random noise and white Gaussian noise mixed with EMR signal effectively.The filter is highly useful for improving the robustness of the coal or rock dynamic disaster monitoring system.

  4. Adaptive Noise Cancellation System for Low Frequency Transmission of Sound in Open Fan Aircraft

    Steven Griffin

    2013-01-01

    Full Text Available This paper describes the use of a structural/acoustic model of a section of a large aircraft to help define the sensor/actuator architecture that was used in a hardware demonstration of adaptive noise cancellation. Disturbances considered were representative of propeller-induced disturbances from an open fan aircraft. Controller on and controller off results from a hardware demonstration on a portion of a large aircraft are also included. The use of the model has facilitated the development of a new testing technique, closely related to modal testing, that can be used to find good structural actuator locations for adaptive noise cancellation.

  5. Adaptive cancellation of light relative intensity noise for fiber optic gyroscope

    Zhong xiao Ji

    2013-07-01

    Full Text Available In order to reduce the relative intensity noise (RIN in the interferometric signal of the fiber optic gyroscope (FOG, an adaptive noise subtraction method is presented, which aims to overcome to the drawbacks that the fixed delay time and gain of the digital noise subtraction method. The drawbacks will make the performance of FOG to be degraded greatly in the changing environment. In the paper the adaptive noise subtraction system based on the recursive least squares algorithm (RLS is formed in FPGA, in which the interferometric signal is regarded as the signal source, and RIN in the free end of the optical fiber coupler of FOG is looked as the noise reference signal. The two critical parameters that minimum delay time and its varying range result from measuring the minimum and maximum delay times of the interferometric signal in a certain temperature range. The off-line and on-line temperature experimental results verify the capability of adapting to the environmental temperature.

  6. Adaptive Cancellation of Light Relative Intensity Noise for Fiber Optic Gyroscope

    Zhongxiao Ji

    2013-07-01

    Full Text Available In order to reduce the relative intensity noise (RIN in the interferometric signal of the fiber optic gyroscope (FOG, an adaptive noise subtraction method is presented, which aims to overcome to the drawbacks that the fixed delay time and gain of the digital noise subtraction method. The drawbacks will make the performance of FOG to be degraded greatly in the changing environment. In the paper the adaptive noise subtraction system based on the recursive least squares algorithm (RLS is formed in FPGA, in which the interferometric signal is regarded as the signal source, and RIN in the free end of the optical fiber coupler of FOG is looked as the noise reference signal. The two critical parameters that minimum delay time and its varying range result from measuring the minimum and maximum delay times of the interferometric signal in a certain temperature range. The off-line and on-line temperature experimental results verify the capability of adapting to the environmental temperature.      

  7. Adaptive V/UV Speech Detection Based on Characterization of Background Noise

    F. Beritelli

    2009-01-01

    Full Text Available The paper presents an adaptive system for Voiced/Unvoiced (V/UV speech detection in the presence of background noise. Genetic algorithms were used to select the features that offer the best V/UV detection according to the output of a background Noise Classifier (NC and a Signal-to-Noise Ratio Estimation (SNRE system. The system was implemented, and the tests performed using the TIMIT speech corpus and its phonetic classification. The results were compared with a nonadaptive classification system and the V/UV detectors adopted by two important speech coding standards: the V/UV detection system in the ETSI ES 202 212 v1.1.2 and the speech classification in the Selectable Mode Vocoder (SMV algorithm. In all cases the proposed adaptive V/UV classifier outperforms the traditional solutions giving an improvement of 25% in very noisy environments.

  8. Adaptive Threshold Clipper Combining Receiver for Fast Frequency Hopping Systems during Partial-Band Noise Jamming

    肖立民; 许希斌; 姚彦

    2001-01-01

    Diversity combining technologies are analyzed for fastfrequency-hopping spread spectrum systems during partial-band noise jamming to develop a novel combining receiver called an Adaptive Threshold Clipper Combining Receiver (ATCCR). The optimal clipping level for an ATCCR is analyzed, computed, and compared with several other diversity combining technologies. Since the ATCCR can estimate the power of the jamming and the number of jammed frequency cells to adaptively adjust the clipper's threshold, the system performance using the adaptive threshold clipper combining technique can be greatly improved.

  9. Transform Domain Robust Variable Step Size Griffiths' Adaptive Algorithm for Noise Cancellation in ECG

    Hegde, Veena; Deekshit, Ravishankar; Satyanarayana, P. S.

    2011-12-01

    The electrocardiogram (ECG) is widely used for diagnosis of heart diseases. Good quality of ECG is utilized by physicians for interpretation and identification of physiological and pathological phenomena. However, in real situations, ECG recordings are often corrupted by artifacts or noise. Noise severely limits the utility of the recorded ECG and thus needs to be removed, for better clinical evaluation. In the present paper a new noise cancellation technique is proposed for removal of random noise like muscle artifact from ECG signal. A transform domain robust variable step size Griffiths' LMS algorithm (TVGLMS) is proposed for noise cancellation. For the TVGLMS, the robust variable step size has been achieved by using the Griffiths' gradient which uses cross-correlation between the desired signal contaminated with observation or random noise and the input. The algorithm is discrete cosine transform (DCT) based and uses symmetric property of the signal to represent the signal in frequency domain with lesser number of frequency coefficients when compared to that of discrete Fourier transform (DFT). The algorithm is implemented for adaptive line enhancer (ALE) filter which extracts the ECG signal in a noisy environment using LMS filter adaptation. The proposed algorithm is found to have better convergence error/misadjustment when compared to that of ordinary transform domain LMS (TLMS) algorithm, both in the presence of white/colored observation noise. The reduction in convergence error achieved by the new algorithm with desired signal decomposition is found to be lower than that obtained without decomposition. The experimental results indicate that the proposed method is better than traditional adaptive filter using LMS algorithm in the aspects of retaining geometrical characteristics of ECG signal.

  10. Time-scale and noise optimality in self-organized critical adaptive networks.

    Kuehn, Christian

    2012-02-01

    Recent studies have shown that adaptive networks driven by simple local rules can organize into "critical" global steady states, providing another framework for self-organized criticality (SOC). We focus on the important convergence to criticality and show that noise and time-scale optimality are reached at finite values. This is in sharp contrast to the previously believed optimal zero noise and infinite time-scale separation case. Furthermore, we discover a noise-induced phase transition for the breakdown of SOC. We also investigate each of these three effects separately by developing models that reveal three generically low-dimensional dynamical behaviors: time-scale resonance, a simplified version of stochastic resonance, which we call steady-state stochastic resonance, and noise-induced phase transitions. PMID:22463275

  11. Signal to noise ratio of free space homodyne coherent optical communication after adaptive optics compensation

    Huang, Jian; Mei, Haiping; Deng, Ke; Kang, Li; Zhu, Wenyue; Yao, Zhoushi

    2015-12-01

    Designing and evaluating the adaptive optics system for coherent optical communication link through atmosphere requires to distinguish the effects of the residual wavefront and disturbed amplitude to the signal to noise ratio. Based on the new definition of coherent efficiency, a formula of signal to noise ratio for describing the performance of coherent optical communication link after wavefront compensation is derived in the form of amplitude non-uniformity and wavefront error separated. A beam quality metric is deduced mathematically to evaluate the effect of disturbed amplitude to the signal to noise ratio. Experimental results show that the amplitude fluctuation on the receiver aperture may reduce the signal to noise ratio about 24% on average when Fried coherent length r0=16 cm.

  12. Adaptive correction procedure for TVL1 image deblurring under impulse noise

    Bai, Minru; Zhang, Xiongjun; Shao, Qianqian

    2016-08-01

    For the problem of image restoration of observed images corrupted by blur and impulse noise, the widely used TVL1 model may deviate from both the data-acquisition model and the prior model, especially for high noise levels. In order to seek a solution of high recovery quality beyond the reach of the TVL1 model, we propose an adaptive correction procedure for TVL1 image deblurring under impulse noise. Then, a proximal alternating direction method of multipliers (ADMM) is presented to solve the corrected TVL1 model and its convergence is also established under very mild conditions. It is verified by numerical experiments that our proposed approach outperforms the TVL1 model in terms of signal-to-noise ratio (SNR) values and visual quality, especially for high noise levels: it can handle salt-and-pepper noise as high as 90% and random-valued noise as high as 70%. In addition, a comparison with a state-of-the-art method, the two-phase method, demonstrates the superiority of the proposed approach.

  13. HIFU-induced gene activation in vitro

    Liu, Yunbo; Zhong, Pei; Kon, Takashi; Li, Chuanyuan

    2001-05-01

    This work investigated the inducible gene activation in cancer cells that were sublethally injured during HIFU treatment. HeLa cells were transfected by an adenovirus vector that encodes GFP under the control of hsp70B promoter, leading to about 65% transfection efficiency. A volume of 10 μL transfected HeLa cells in suspension (5×107 cells/ml) were placed at the bottom of a PCR tube so that the cell suspension could be heated to a peak temperature of 50°C, 60°C, and 70°C for 120, 10, and 1 s, respectively, by a focused 1.1-MHz HIFU transducer operated at a peak negative pressure of -2.7 MPa at different duty cycles. One day after HIFU treatment, cell viability was determined to be 63%, 35%, and 18%, respectively, based on Trypan Blue exclusion test. Importantly, in all test groups, inducible GFP expression was detected in about 40%-50% of the surviving cells with GFP intensity increased by 25-fold based on flow cytometry analysis. These results demonstrate that even under the short exposure duration of HIFU treatment, inducible gene expression could be produced in sublethally injured cell population in vitro. Further studies are underway to explore the optimal HIFU condition for gene activation in vivo.

  14. Real-time monitoring of HIFU treatment using pulse inversion

    Song, Jae Hee; Yoo, Yangmo; Song, Tai-Kyong; Chang, Jin Ho

    2013-08-01

    Ultrasound (US) imaging is widely used for the real-time guidance of high-intensity focused ultrasound (HIFU) treatment at a relatively low cost. However, ultrasound image guided HIFU (USgHIFU) is limited in the real-time monitoring of HIFU treatment due to the large amplitude HIFU signals received by the US imaging transducer. The amplitude of the HIFU scattered signal is generally much higher than the amplitude of the pulse-echo signal received by the imaging transducer. This creates an interference pattern obscuring the image of the tissue. As such, it is difficult to monitor lesion location. This paper proposes a real-time monitoring method to be performed concurrently with the HIFU insonation, but without HIFU interference, which allows for the improvement of treatment accuracy and safety in USgHIFU. The proposed method utilizes the physical properties of pulse inversion which is capable of removing the fundamental and odd harmonic components of the HIFU interference. Therefore, it is possible to secure the desired spectral bandwidth used to construct US images for HIFU treatment monitoring. The performance of the proposed method was evaluated through experiments with both a bovine serum albumin phantom and a chicken breast. The results demonstrated that the proposed method is capable of providing interference-free US images, thus successfully allowing for US imaging during HIFU treatment.

  15. Real-time monitoring of HIFU treatment using pulse inversion

    Ultrasound (US) imaging is widely used for the real-time guidance of high-intensity focused ultrasound (HIFU) treatment at a relatively low cost. However, ultrasound image guided HIFU (USgHIFU) is limited in the real-time monitoring of HIFU treatment due to the large amplitude HIFU signals received by the US imaging transducer. The amplitude of the HIFU scattered signal is generally much higher than the amplitude of the pulse-echo signal received by the imaging transducer. This creates an interference pattern obscuring the image of the tissue. As such, it is difficult to monitor lesion location. This paper proposes a real-time monitoring method to be performed concurrently with the HIFU insonation, but without HIFU interference, which allows for the improvement of treatment accuracy and safety in USgHIFU. The proposed method utilizes the physical properties of pulse inversion which is capable of removing the fundamental and odd harmonic components of the HIFU interference. Therefore, it is possible to secure the desired spectral bandwidth used to construct US images for HIFU treatment monitoring. The performance of the proposed method was evaluated through experiments with both a bovine serum albumin phantom and a chicken breast. The results demonstrated that the proposed method is capable of providing interference-free US images, thus successfully allowing for US imaging during HIFU treatment. (paper)

  16. Cavitation damage in blood clots under HIFU

    Weiss, Hope; Ahadi, Golnaz; Hoelscher, Thilo; Szeri, Andrew

    2010-11-01

    High Intensity Focused Ultrasound (HIFU) has been shown to accelerate thrombolysis, the dissolution of blood clots, in vitro and in vivo, for treatment of ischemic stroke. Cavitation in sonothrombolysis is thought to play an important role, although the mechanisms are not fully understood. The damage to a blood clot associated with bubble collapses in a HIFU field is studied. The region of damage caused by a bubble collapse on the fibrin network of the blood clot exposed to HIFU is estimated, and compared with experimental assessment of the damage. The mechanical damage to the network caused by a bubble is probed using two independent approaches, a strain based method and an energy based method. Immunoflourescent fibrin staining is used to assess the region of damage experimentally.

  17. Developing de-noising methods for ultrasonic NDT based on wavelet transform and adaptive filtering

    Digital signal processing methods based on the advanced wavelet transform and adaptive filtering were developed to deal with the problem of material's grain noise in ultrasonic Non Destructive Testing applications. The developed methods were implemented in lab View (Laboratory Virtual Instruments Engineering Workbench) programming environment. The experimental ultrasonic signals were obtained by inspecting stainless steel blocks with side-drilled holes, and carbon steel welded plates contain three types of welding flaws: root crack, centerline crack and slag inclusion. The simulations were carried out using CIVA Non Destructive Evaluation modeling software. Wavelet transform has introduced innovative changes in different fields of science and engineering. One of its important applications is in de-noising of signals and images. Wavelet packet is an efficient de-noising method, which has been used for ultrasonic Non Destructive Testing signals de-noising, wavelet packet is generalizations of the discrete wavelet transform. The first part of this research proposes the use of the un decimated wavelet transform in implementing wavelet packets to overcome the limitation of the shift variance encountered in discrete wavelet transform. Simulations and experiments were carried out on flaw's echo signals contaminated with material's grain noise, various wavelet transform processing parameters were investigated, including the number of decomposition levels, analyzing wavelets, and threshold setting. The results showed superior de-noising effect of the developed method over the conventional one. In the second part of the research, improvements are proposed to the multi-stage adaptive filter, which has been reported in a previous study as an advanced adaptive noise cancellation system for ultrasonic None Destructive Testing applications. The multi stage adaptive filter is limited by the slow convergence speed of the least-mean-squares algorithm as well as

  18. Effects of MRTI sampling characteristics on estimation of HIFU SAR and tissue thermal diffusivity

    While the non-invasive and three-dimensional nature of magnetic-resonance temperature imaging (MRTI) makes it a valuable tool for high-intensity focused ultrasound (HIFU) treatments, random and systematic errors in MRTI measurements may propagate into temperature-based parameter estimates used for pretreatment planning. This study assesses the MRTI effects of zero-mean Gaussian noise (SD = 0.0–2.0 °C), temporal sampling (tacq = 1.0–8.0 s), and spatial averaging (Res = 0.5–2.0 mm isotropic) on HIFU temperature measurements and temperature-based estimates of the amplitude and full width half maximum (FWHM) of the HIFU specific absorption rate and of tissue thermal diffusivity. The ultrasound beam used in simulations and ex vivo pork loin experiments has lateral and axial FWHM dimensions of 1.4 mm and 7.9 mm respectively. For spatial averaging simulations, beams with lateral FWHM varying from 1.2–2.2 mm are also assessed. Under noisy conditions, parameter estimates are improved by fitting to data from larger voxel regions. Varying the temporal sampling results in minimal changes in measured temperatures (3 or smaller is required to keep errors in temperature and all estimated parameters less than 10%. By quantifying the errors associated with these sampling characteristics, this work provides researchers with appropriate MRTI conditions for obtaining estimates of parameters essential to pretreatment modeling of HIFU thermal therapies. (paper)

  19. Background noise cancellation of manatee vocalizations using an adaptive line enhancer.

    Yan, Zheng; Niezrecki, Christopher; Cattafesta, Louis N; Beusse, Diedrich O

    2006-07-01

    The West Indian manatee (Trichechus manatus latirostris) has become an endangered species partly because of an increase in the number of collisions with boats. A device to alert boaters of the presence of manatees is desired. Previous research has shown that background noise limits the manatee vocalization detection range (which is critical for practical implementation). By improving the signal-to-noise ratio of the measured manatee vocalization signal, it is possible to extend the detection range. The finite impulse response (FIR) structure of the adaptive line enhancer (ALE) can detect and track narrow-band signals buried in broadband noise. In this paper, a constrained infinite impulse response (IIR) ALE, called a feedback ALE (FALE), is implemented to reduce the background noise. In addition, a bandpass filter is used as a baseline for comparison. A library consisting of 100 manatee calls spanning ten different signal categories is used to evaluate the performance of the bandpass filter, FIR-ALE, and FALE. The results show that the FALE is capable of reducing background noise by about 6.0 and 21.4 dB better than that of the FIR-ALE and bandpass filter, respectively, when the signal-to-noise ratio (SNR) of the original manatee call is -5 dB. PMID:16875212

  20. REMOVAL OF HIGH DENSITY IMPULSE NOISE USING MORPHOLOGICAL BASED ADAPTIVE UNSYMMETRICAL TRIMMED MID-POINT FILTER

    S. Saravanakumar

    2014-01-01

    Full Text Available A Morphological based Adaptive Unsymmetrical Trimmed Mid-Point Filter (MAUTMPF for the restoration of gray scale images corrupted by salt and pepper noise for varying noise densities is proposed in this study. Images corrupted by impulsive noise severely hinder subsequent image processing tasks, such as edge detection, image segmentation, object recognition, etc. Therefore, it is absolutely essential to restore the original image from the corrupted image. The proposed algorithm replaces the corrupted pixel by mid point value out of the retained pixels other than 0’s and 255’s in a 3×3 window. The essential condition for the validity of the window is that at least two pixels in the selected window should be uncorrupted; if not the window size is incremented by 2. The iteration stops when the window size reaches 7. In particular case, when the condition for validity doesn’t hold in 7×7 window then the original 3×3 window is chosen and midpoint of minimum and maximum values of already processed pixels is replaced with the centre pixel. experimental evaluation using MATLAB reveals that our MAUTMPF shows better performance compared to the previous de-noising algorithms in terms of Peak Signal-to-Noise Ratio (PSNR and Mean Square Error (MSE for noise densities up to 90%. The validity of the proposed algorithm is verified by testing it for different gray scale images.

  1. Intercostal HIFU Treatment: A Tissue Phantom

    High-intensity focused ultrasound (HIFU) when used clinically to treat liver and kidney tumours is often directed between the ribs. This paper details the construction of a tissue phantom, incorporating ribs, and its use to assess the clinical safety of HIFU exposures. The prefocal, acoustic side-lobes of the ultrasonic beam were studied with and without rib interference, and thermocouples used to assess in-situ temperature changes. The results show that there are implications in regards to the safety of clinical treatment, should the operator be unaware of the characteristics of the transducer being used

  2. HIFU as a Neoadjuvant Therapy in Cancer Treatment

    Zhong, P.; Xing, F.; Huang, X.; Zhu, H.; Lo, H. W.; Zhong, X.; Pruitt, S.; Robertson, C.

    2011-09-01

    To broaden the application spectrum of HIFU in cancer therapy, we performed a pilot experiment to evaluate the potential of using HIFU as a neoadjuvant therapy prior to surgery. Mice bearing wild-type B16F10 melanoma inoculated subcutaneously were either untreated (control) or treated by HIFU, CPA-7 or HIFU+CPA-7 before surgical resection of the primary tumor two days after HIFU treatment. The animals were then followed for four weeks or up to the humane endpoint to determine local recurrence, distant metastasis, and survival rate. The results demonstrate that animals treated by HIFU+CPA-7 (which is a small molecule that suppresses STAT3 activity) had a significantly lower recurrence rate, and slower growth of the recurrent tumor, with concomitantly higher survival rate, followed by those treated with CPA-7 and HIFU, respectively. Immunological assays revealed that CPA-7 treatment could significantly lower STAT3, and subsequently, Treg activities. In particular, the combination of HIFU and CPA-7 can induce a much stronger anti-tumor immune response than HIFU or surgery alone, as assessed by CTL and IFN-γ secretion. Overall, our results suggest that HIFU in combination with immunotherapy strategies has the potential to be used as a neoadjuvant therapy to prime the host with a strong anti-tumor immune response before surgical resection of the primary tumor. This multimodality, combinational therapy has the potential to greatly broaden the range of HIFU applications in cancer therapy with lower tumor recurrence and improved survival rate.

  3. Noises Cancelling Adaptive Methods in Control Telemetry Systems of Oil Electrical Submersible Pumps

    Ustun, Ozgur; Yilmaz, Murat; Ali Zada, Parviz; Tuncay, R. Nejat

    2015-01-01

    The main ideas of this paper are that only some from more than 10 MATLAB Adaptive Methods library may be useful and can be recommended to filter out High-Noises in similar Control Telemetry Channels of Electric Power Components like ESP Systems: only four of applied have shown successfully good results in the early prediction of the ESP motor real insulation disruption (like Sign-error, Sign-data and Sign-sign filters). The best among the ten analyzed adaptive filter algorithms was recognized...

  4. Marginalized adaptive particle filtering for nonlinear models with unknown time-varying noise parameters

    Ökzan, E.; Šmídl, Václav; Saha, S.; Lundquist, C.; Gustafsson, F.

    2013-01-01

    Roč. 49, č. 6 (2013), s. 1566-1575. ISSN 0005-1098 R&D Projects: GA ČR(CZ) GAP102/11/0437 Keywords : Unknown Noise Statistics * Adaptive Filtering * Marginalized Particle Filter * Bayesian Conjugate prior Subject RIV: BC - Control Systems Theory Impact factor: 3.132, year: 2013 http://library.utia.cas.cz/separaty/2013/AS/smidl-0393047.pdf

  5. AN ADAPTIVE OPTIMAL KALMAN FILTER FOR STOCHASTIC VIBRATION CONTROL SYSTEM WITH UNKNOWN NOISE VARIANCES

    Li Shu; Zhuo Jiashou; Ren Qingwen

    2000-01-01

    In this paper, an optimal criterion is presented for adaptive Kalman filter in a control sys tem with unknown variances of stochastic vibration by constructing a function of noise variances and minimizing the function. We solve the model and measure variances by using DFP optimal method to guarantee the results of Kalman filter to be optimized. Finally, the control of vibration can be implemented by LQG method.

  6. Dynamic Adaptive Median Filter (DAMF for Removal of High Density Impulse Noise

    Punyaban Patel

    2012-10-01

    Full Text Available This paper proposes a novel adaptive filtering scheme to remove impulse noise from images. The scheme replaces the corrupted test pixel with the median value of non-corrupted neighboring pixels selected from a window dynamically. If the number of non-corrupted pixels in the selected window is not sufficient, a window of next higher size is chosen. Thus window size is automatically adapted based on the density of noise in the image as well as the density of corruption local to a window. As a result window size may vary pixel to pixel while filtering. The scheme is simple to implement and do not require multiple iterations. The efficacy of the proposed scheme is evaluated with respect to subjective as well as objective parameters on standard images on various noise densities. Comparative analysis reveals that the proposed scheme has improved performance over other schemes, preferably in high density impulse noise cases. Further, the computational overhead is also less as compared its competent scheme.

  7. Speech perception at positive signal-to-noise ratios using adaptive adjustment of time compression.

    Schlueter, Anne; Brand, Thomas; Lemke, Ulrike; Nitzschner, Stefan; Kollmeier, Birger; Holube, Inga

    2015-11-01

    Positive signal-to-noise ratios (SNRs) characterize listening situations most relevant for hearing-impaired listeners in daily life and should therefore be considered when evaluating hearing aid algorithms. For this, a speech-in-noise test was developed and evaluated, in which the background noise is presented at fixed positive SNRs and the speech rate (i.e., the time compression of the speech material) is adaptively adjusted. In total, 29 younger and 12 older normal-hearing, as well as 24 older hearing-impaired listeners took part in repeated measurements. Younger normal-hearing and older hearing-impaired listeners conducted one of two adaptive methods which differed in adaptive procedure and step size. Analysis of the measurements with regard to list length and estimation strategy for thresholds resulted in a practical method measuring the time compression for 50% recognition. This method uses time-compression adjustment and step sizes according to Versfeld and Dreschler [(2002). J. Acoust. Soc. Am. 111, 401-408], with sentence scoring, lists of 30 sentences, and a maximum likelihood method for threshold estimation. Evaluation of the procedure showed that older participants obtained higher test-retest reliability compared to younger participants. Depending on the group of listeners, one or two lists are required for training prior to data collection. PMID:26627804

  8. Adaptive cancellation of geomagnetic background noise for magnetic anomaly detection using coherence

    Magnetic anomaly detection (MAD) is an effective method for the detection of ferromagnetic targets against background magnetic fields. Currently, the performance of MAD systems is mainly limited by the background geomagnetic noise. Several techniques have been developed to detect target signatures, such as the synchronous reference subtraction (SRS) method. In this paper, we propose an adaptive coherent noise suppression (ACNS) method. The proposed method is capable of evaluating and detecting weak anomaly signals buried in background geomagnetic noise. Tests with real-world recorded magnetic signals show that the ACNS method can excellently remove the background geomagnetic noise by about 21 dB or more in high background geomagnetic field environments. Additionally, as a general form of the SRS method, the ACNS method offers appreciable advantages over the existing algorithms. Compared to the SRS method, the ACNS algorithm can eliminate the false target signals and represents a noise suppressing capability improvement of 6.4 dB. The positive outcomes in terms of intelligibility make this method a potential candidate for application in MAD systems. (paper)

  9. Noise

    Noise is all around you, from televisions and radios to lawn mowers and washing machines. Normally, you ... sensitive structures of the inner ear and cause noise-induced hearing loss. More than 30 million Americans ...

  10. A comparison of adaptive and notch filtering for removing electromagnetic noise from monopolar surface electromyographic signals

    The purpose of this study was to compare the monopolar electromyographic (EMG) amplitude versus isometric force relationships from three signal processing methods (raw versus notch filtering versus adaptive filtering). Seventeen healthy subjects (mean ± SD age = 24.6 ± 4.3 yr) performed incremental isometric muscle actions of the dominant leg extensors in 10% increments from 10% to 100% of the maximum voluntary contraction (MVC). During each muscle action, a monopolar surface EMG signal was recorded from the vastus lateralis and processed with the three signal processing methods. The linear slope coefficients for the EMG amplitude versus isometric force relationships were equivalent for the three signal processing methods and correlated (r = 0.997–0.999). However, the mean amplitude values for the notch-filtered signals were less than those for the raw and adaptive-filtered signals. Thus, adaptive filtering may be the best method for removing electromagnetic noise from monopolar surface EMG signals

  11. The effects of an adaptive directional BEAM microphone on the mismatch negativity responses of cochlear implant users in noise

    ERDOĞAN*, Asuman; Akdaş, Ferda

    2013-01-01

    To investigate the effects of noise on mismatch negativity (MMN) responses and the possible benefits of an adaptive directional BEAM microphone in noise during MMN recordings, and to compare the cochlear implant-evoked potential results with normal hearing subjects. Materials and methods: /da/ and /di/ speech stimuli were used to elicit MMN responses in 11 Freedom cochlear implant users and in 11 normal hearing subjects. Speech noise was delivered at 80 dB sound pressure level (-10 dB signa...

  12. Three-dimensional anisotropic adaptive filtering of projection data for noise reduction in cone beam CT

    Purpose: The combination of quickly rotating C-arm gantry with digital flat panel has enabled the acquisition of three-dimensional data (3D) in the interventional suite. However, image quality is still somewhat limited since the hardware has not been optimized for CT imaging. Adaptive anisotropic filtering has the ability to improve image quality by reducing the noise level and therewith the radiation dose without introducing noticeable blurring. By applying the filtering prior to 3D reconstruction, noise-induced streak artifacts are reduced as compared to processing in the image domain. Methods: 3D anisotropic adaptive filtering was used to process an ensemble of 2D x-ray views acquired along a circular trajectory around an object. After arranging the input data into a 3D space (2D projections + angle), the orientation of structures was estimated using a set of differently oriented filters. The resulting tensor representation of local orientation was utilized to control the anisotropic filtering. Low-pass filtering is applied only along structures to maintain high spatial frequency components perpendicular to these. The evaluation of the proposed algorithm includes numerical simulations, phantom experiments, and in-vivo data which were acquired using an AXIOM Artis dTA C-arm system (Siemens AG, Healthcare Sector, Forchheim, Germany). Spatial resolution and noise levels were compared with and without adaptive filtering. A human observer study was carried out to evaluate low-contrast detectability. Results: The adaptive anisotropic filtering algorithm was found to significantly improve low-contrast detectability by reducing the noise level by half (reduction of the standard deviation in certain areas from 74 to 30 HU). Virtually no degradation of high contrast spatial resolution was observed in the modulation transfer function (MTF) analysis. Although the algorithm is computationally intensive, hardware acceleration using Nvidia's CUDA Interface provided an 8.9-fold

  13. An Innovations-Based Noise Cancelling Technique on Inverse Kepstrum Whitening Filter and Adaptive FIR Filter in Beamforming Structure

    Jinsoo Jeong

    2011-06-01

    Full Text Available This paper presents an acoustic noise cancelling technique using an inverse kepstrum system as an innovations-based whitening application for an adaptive finite impulse response (FIR filter in beamforming structure. The inverse kepstrum method uses an innovations-whitened form from one acoustic path transfer function between a reference microphone sensor and a noise source so that the rear-end reference signal will then be a whitened sequence to a cascaded adaptive FIR filter in the beamforming structure. By using an inverse kepstrum filter as a whitening filter with the use of a delay filter, the cascaded adaptive FIR filter estimates only the numerator of the polynomial part from the ratio of overall combined transfer functions. The test results have shown that the adaptive FIR filter is more effective in beamforming structure than an adaptive noise cancelling (ANC structure in terms of signal distortion in the desired signal and noise reduction in noise with nonminimum phase components. In addition, the inverse kepstrum method shows almost the same convergence level in estimate of noise statistics with the use of a smaller amount of adaptive FIR filter weights than the kepstrum method, hence it could provide better computational simplicity in processing. Furthermore, the rear-end inverse kepstrum method in beamforming structure has shown less signal distortion in the desired signal than the front-end kepstrum method and the front-end inverse kepstrum method in beamforming structure.

  14. Multi-microphone adaptive noise reduction strategies for coordinated stimulation in bilateral cochlear implant devices.

    Kokkinakis, Kostas; Loizou, Philipos C

    2010-05-01

    Bilateral cochlear implant (BI-CI) recipients achieve high word recognition scores in quiet listening conditions. Still, there is a substantial drop in speech recognition performance when there is reverberation and more than one interferers. BI-CI users utilize information from just two directional microphones placed on opposite sides of the head in a so-called independent stimulation mode. To enhance the ability of BI-CI users to communicate in noise, the use of two computationally inexpensive multi-microphone adaptive noise reduction strategies exploiting information simultaneously collected by the microphones associated with two behind-the-ear (BTE) processors (one per ear) is proposed. To this end, as many as four microphones are employed (two omni-directional and two directional) in each of the two BTE processors (one per ear). In the proposed two-microphone binaural strategies, all four microphones (two behind each ear) are being used in a coordinated stimulation mode. The hypothesis is that such strategies combine spatial information from all microphones to form a better representation of the target than that made available with only a single input. Speech intelligibility is assessed in BI-CI listeners using IEEE sentences corrupted by up to three steady speech-shaped noise sources. Results indicate that multi-microphone strategies improve speech understanding in single- and multi-noise source scenarios. PMID:21117762

  15. Adaptive ambient noise tomography and its application to the Garlock Fault, southern California

    Li, Peng; Lin, Guoqing

    2014-05-01

    Traditional ambient noise tomography methods using regular grid nodes are often ill posed because the inversion grids do not always represent the distribution of ray paths. Large grid spacing is usually used to reduce the number of inversion parameters, which may not be able to solve for small-scale velocity structure. We present a new adaptive tomography method with irregular grids that provides a few advantages over the traditional methods. First, irregular grids with different sizes and shapes can fit the ray distribution better and the traditionally ill-posed problem can become more stable owing to the different parametrizations. Secondly, the data in the area with dense ray sampling will be sufficiently utilized so that the model resolution can be greatly improved. Both synthetic and real data are used to test the newly developed tomography algorithm. In synthetic data tests, we compare the resolution and stability of the traditional and adaptive methods. The results show that adaptive tomography is more stable and performs better in improving the resolution in the area with dense ray sampling. For real data, we extract the ambient noise signals of the seismic data near the Garlock Fault region, obtained from the Southern California Earthquake Data Center. The resulting group velocity of Rayleigh wave is well correlated with the geological structures. High-velocity anomalies are shown in the cold southern Sierra Nevada, the Tehachapi Mountains and the Western San Gabriel Mountains. In contrast, low velocity values are prominent in the southern San Joaquin Valley and western Mojave.

  16. HIFU Tissue Ablation: Concept and Devices.

    Ter Haar, Gail

    2016-01-01

    High intensity focused ultrasound (HIFU) is rapidly gaining clinical acceptance as a technique capable of providing non-invasive heating and ablation for a wide range of applications. Usually requiring only a single session, treatments are often conducted as day case procedures, with the patient either fully conscious, lightly sedated or under light general anesthesia. HIFU scores over other thermal ablation techniques because of the lack of necessity for the transcutaneous insertion of probes into the target tissue. Sources placed either outside the body (for treatment of tumors or abnormalities of the liver, kidney, breast, uterus, pancreas brain and bone), or in the rectum (for treatment of the prostate), provide rapid heating of a target tissue volume, the highly focused nature of the field leaving tissue in the ultrasound propagation path relatively unaffected. Numerous extra-corporeal, transrectal and interstitial devices have been designed to optimize application-specific treatment delivery for the wide-ranging areas of application that are now being explored with HIFU. Their principle of operation is described here, and an overview of their design principles is given. PMID:26486329

  17. Adaptive noise cancelling and time-frequency techniques for rail surface defect detection

    Liang, B.; Iwnicki, S.; Ball, A.; Young, A. E.

    2015-03-01

    Adaptive noise cancelling (ANC) is a technique which is very effective to remove additive noises from the contaminated signals. It has been widely used in the fields of telecommunication, radar and sonar signal processing. However it was seldom used for the surveillance and diagnosis of mechanical systems before late of 1990s. As a promising technique it has gradually been exploited for the purpose of condition monitoring and fault diagnosis. Time-frequency analysis is another useful tool for condition monitoring and fault diagnosis purpose as time-frequency analysis can keep both time and frequency information simultaneously. This paper presents an ANC and time-frequency application for railway wheel flat and rail surface defect detection. The experimental results from a scaled roller test rig show that this approach can significantly reduce unwanted interferences and extract the weak signals from strong background noises. The combination of ANC and time-frequency analysis may provide us one of useful tools for condition monitoring and fault diagnosis of railway vehicles.

  18. Adaptive spatial filtering of daytime sky noise in a satellite quantum key distribution downlink receiver

    Gruneisen, Mark T.; Sickmiller, Brett A.; Flanagan, Michael B.; Black, James P.; Stoltenberg, Kurt E.; Duchane, Alexander W.

    2016-02-01

    Spatial filtering is an important technique for reducing sky background noise in a satellite quantum key distribution downlink receiver. Atmospheric turbulence limits the extent to which spatial filtering can reduce sky noise without introducing signal losses. Using atmospheric propagation and compensation simulations, the potential benefit of adaptive optics (AO) to secure key generation (SKG) is quantified. Simulations are performed assuming optical propagation from a low-Earth-orbit satellite to a terrestrial receiver that includes AO. Higher-order AO correction is modeled assuming a Shack-Hartmann wavefront sensor and a continuous-face-sheet deformable mirror. The effects of atmospheric turbulence, tracking, and higher-order AO on the photon capture efficiency are simulated using statistical representations of turbulence and a time-domain wave-optics hardware emulator. SKG rates are calculated for a decoy-state protocol as a function of the receiver field of view for various strengths of turbulence, sky radiances, and pointing angles. The results show that at fields of view smaller than those discussed by others, AO technologies can enhance SKG rates in daylight and enable SKG where it would otherwise be prohibited as a consequence of background optical noise and signal loss due to propagation and turbulence effects.

  19. Development of adaptive IIR filtered-e LMS algorithm for active noise control

    SUN Xu; MENG Guang; TENG Pengxiao; CHEN Duanshi

    2003-01-01

    Compared to finite impulse response (FIR) filters, infinite impulse response (IIR)filters can match the system better with much fewer coefficients, and hence the computationload is saved and the performance improves. Therefore, it is attractive to use IIR filters insteadof FIR filters in active noise control (ANC). However, filtered-U LMS (FULMS) algorithm, theIIR filter-based algorithm commonly used so far cannot ensure global convergence. A new IIRfilter based adaptive algorithm, which can ensure global convergence with computation loadonly slightly increasing, is proposed in this paper. The new algorithm is called as filtered-eLMS algorithm since the error signal of which need to be filtered. Simulation results show thatthe FELMS algorithm presents better performance than the FULMS algorithm.

  20. Noise correlation-based adaptive polarimetric image representation for contrast enhancement of a polarized beacon in fog

    Panigrahi, Swapnesh; Fade, Julien; Alouini, Mehdi

    2015-10-01

    We show the use of a simplified snapshot polarimetric camera along with an adaptive image processing for optimal detection of a polarized light beacon through fog. The adaptive representation is derived using theoretical noise analysis of the data at hand and is shown to be optimal in the Maximum likelihood sense. We report that the contrast enhancing optimal representation that depends on the background noise correlation differs in general from standard representations like polarimetric difference image or polarization filtered image. Lastly, we discuss a detection strategy to reduce the false positive counts.

  1. High-Intensity Focused Ultrasound (HIFU) in Localized Prostate Cancer Treatment

    Alkhorayef, Mohammed; Mahmoud, Mustafa Z.; Alzimami, Khalid S.; Sulieman, Abdelmoneim; Fagiri, Maram A.

    2015-01-01

    Summary Background High-intensity focused ultrasound (HIFU) applies high-intensity focused ultrasound energy to locally heat and destroy diseased or damaged tissue through ablation. This study intended to review HIFU to explain the fundamentals of HIFU, evaluate the evidence concerning the role of HIFU in the treatment of prostate cancer (PC), review the technologies used to perform HIFU and the published clinical literature regarding the procedure as a primary treatment for PC. Material/Meth...

  2. A Split-and-Merge-Based Uterine Fibroid Ultrasound Image Segmentation Method in HIFU Therapy.

    Menglong Xu

    Full Text Available High-intensity focused ultrasound (HIFU therapy has been used to treat uterine fibroids widely and successfully. Uterine fibroid segmentation plays an important role in positioning the target region for HIFU therapy. Presently, it is completed by physicians manually, reducing the efficiency of therapy. Thus, computer-aided segmentation of uterine fibroids benefits the improvement of therapy efficiency. Recently, most computer-aided ultrasound segmentation methods have been based on the framework of contour evolution, such as snakes and level sets. These methods can achieve good performance, although they need an initial contour that influences segmentation results. It is difficult to obtain the initial contour automatically; thus, the initial contour is always obtained manually in many segmentation methods. A split-and-merge-based uterine fibroid segmentation method, which needs no initial contour to ensure less manual intervention, is proposed in this paper. The method first splits the image into many small homogeneous regions called superpixels. A new feature representation method based on texture histogram is employed to characterize each superpixel. Next, the superpixels are merged according to their similarities, which are measured by integrating their Quadratic-Chi texture histogram distances with their space adjacency. Multi-way Ncut is used as the merging criterion, and an adaptive scheme is incorporated to decrease manual intervention further. The method is implemented using Matlab on a personal computer (PC platform with Intel Pentium Dual-Core CPU E5700. The method is validated on forty-two ultrasound images acquired from HIFU therapy. The average running time is 9.54 s. Statistical results showed that SI reaches a value as high as 87.58%, and normHD is 5.18% on average. It has been demonstrated that the proposed method is appropriate for segmentation of uterine fibroids in HIFU pre-treatment imaging and planning.

  3. Usefulness of noise adaptive non-linear Gaussian filter in FDG-PET study

    In positron emission tomography (PET) studies, shortening transmission (TR) scan time can improve patient comfort and increase scanner throughput. However, PET images from short TR scans may be degraded due to the statistical noise included in the TR image. The purpose of this study was to apply non-linear Gaussian (NLG) and noise adaptive NLG (ANLG) filters to TR images, and to evaluate the extent of noise reduction by the ANLG filter in comparison with that by the NLG filter using phantom and clinical studies. In phantom studies, pool phantoms of various diameters and injected doses of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) were used and the coefficients of variation (CVs) of the counts in the TR images processed with the NLG and ANLG filters were compared. In clinical studies, two normal volunteers and 13 patients with tumors were studied. In volunteer studies, the CV values in the liver were compared. In patient studies, the standardized uptake values (SUVs) of tumors in the emission images were obtained after processing the TR images using the NLG and ANLG filters. In phantom studies, the CV values in the TR images processed with the ANLG filter were smaller than those in the images processed with the NLG filter. When using the ANLG filter, their dependency on the phantom size, injected dose of FDG and TR scan time was smaller than when using the NLG filter. In volunteer studies, the CV values in the images processed with the ANLG filter were smaller than those in the images processed with the NLG filter, and were almost constant regardless of the TR scan time. In patient studies, there was an excellent correlation between the SUVs obtained from the images with a TR scan time of 7 min processed with the NLG filter (x) and those obtained from the images with a TR scan time of 4 min processed with the ANLG filter (y) (r=0.995, y=1.034x-0.075). Our results suggest that the ANLG filter is effective and useful for noise reduction in TR images and shortening TR scan

  4. Rapid HIFU autofocusing using the entire MR-ARFI image

    Phase aberrations and attenuations caused by bone can defocus HIFU in the brain and organs behind the ribcage. To refocus the beam, MR-ARFI can be used to measure tissue displacements created by each element in the transducer, and optimize driving signal delays and amplitudes. We introduce a new MR-ARFI-based autofocusing method that requires many fewer image acquisitions than current methods. The method is validated in simulations of bone and brain HIFU transducers, and compared to a conventional method.

  5. PREVENTION OF DYSURIA AFTER HIFU THERAPY FOR PROSTATE CANCER

    A. Yu. Shestaev; V. V. Protoshchak; L. M. Sinelnikov; V. A. Kardinalova; R. A. Yeloev

    2014-01-01

    Objective: to identify factors for the development of dysuria and its prevention in patients with prostate cancer (PC) after high-intensity focused ultrasound (HIFU) therapy.Subjects and methods. In September 2008 to June 2013, the Clinic of Urology, S.M. Kirov Military Medical Academy, treated 98 patients, by performing HIFU sessions on an Ablatherm apparatus (EDAP, France). All the patients underwent transurethral resection of the prostate (TURP) to reduce the volume of the ablated tissue. ...

  6. PREVENTION OF DYSURIA AFTER HIFU THERAPY FOR PROSTATE CANCER

    A. Yu. Shestaev

    2014-07-01

    Full Text Available Objective: to identify factors for the development of dysuria and its prevention in patients with prostate cancer (PC after high-intensity focused ultrasound (HIFU therapy.Subjects and methods. In September 2008 to June 2013, the Clinic of Urology, S.M. Kirov Military Medical Academy, treated 98 patients, by performing HIFU sessions on an Ablatherm apparatus (EDAP, France. All the patients underwent transurethral resection of the prostate (TURP to reduce the volume of the ablated tissue. The patients were divided into 2 groups: 1 29 patients underwent TURP 3 days before HIFU therapy; 2 69 did this 1 month before major surgery. Each group was divided into 2 subgroups: 1 after ultrasound ablation, a urethral catheter was inserted for 10 days; 2 epicystostoma was applied, followed by its overlapping on day 3 postablation and spontaneous urination. The postoperative incidence of dysuria was estimated from subjective (complaints, voiding diary, and Inter-national Prostate Symptom Score and objective (uroflowmetry, small pelvic ultrasonography with determination of residual urine volume criteria.Results. In the patients who had undergone TURP one month before HIFU therapy, grades I–II urinary incontinence and urethral pros-tatic stricture occurred much less infrequently than in those who had undergone this maneuver 3 days prior to major surgery. Urinary in-continence and urethral prostatic stricture occurred 2-fold more frequently after TURP being carried out 3 days before HIFU therapy than after the urethral catheter being inserted. TURP performed one month before HIFU therapy showed no great difference in the incidence complications regardless of the type of bladder drainage.Conclusion. The short interval between TURP and HIFU therapy for PC increases the risk of postoperative dysuric events. The optimal time to perform TURP prior to HIFU therapy is 1 month.

  7. PREVENTION OF DYSURIA AFTER HIFU THERAPY FOR PROSTATE CANCER

    A. Yu. Shestaev

    2014-01-01

    Full Text Available Objective: to identify factors for the development of dysuria and its prevention in patients with prostate cancer (PC after high-intensity focused ultrasound (HIFU therapy.Subjects and methods. In September 2008 to June 2013, the Clinic of Urology, S.M. Kirov Military Medical Academy, treated 98 patients, by performing HIFU sessions on an Ablatherm apparatus (EDAP, France. All the patients underwent transurethral resection of the prostate (TURP to reduce the volume of the ablated tissue. The patients were divided into 2 groups: 1 29 patients underwent TURP 3 days before HIFU therapy; 2 69 did this 1 month before major surgery. Each group was divided into 2 subgroups: 1 after ultrasound ablation, a urethral catheter was inserted for 10 days; 2 epicystostoma was applied, followed by its overlapping on day 3 postablation and spontaneous urination. The postoperative incidence of dysuria was estimated from subjective (complaints, voiding diary, and Inter-national Prostate Symptom Score and objective (uroflowmetry, small pelvic ultrasonography with determination of residual urine volume criteria.Results. In the patients who had undergone TURP one month before HIFU therapy, grades I–II urinary incontinence and urethral pros-tatic stricture occurred much less infrequently than in those who had undergone this maneuver 3 days prior to major surgery. Urinary in-continence and urethral prostatic stricture occurred 2-fold more frequently after TURP being carried out 3 days before HIFU therapy than after the urethral catheter being inserted. TURP performed one month before HIFU therapy showed no great difference in the incidence complications regardless of the type of bladder drainage.Conclusion. The short interval between TURP and HIFU therapy for PC increases the risk of postoperative dysuric events. The optimal time to perform TURP prior to HIFU therapy is 1 month.

  8. Rapid HIFU autofocusing using the entire MR-ARFI image

    Grissom, William A.; Kaye, Elena; Pauly, Kim Butts; Zur, Yuval; Yeo, Desmond; Medan, Yoav; Davis, Cynthia [Biomedical Engineering, Vanderbilt University, Nashville, Tennessee (United States); Electrical Engineering, Stanford University, Stanford, California (United States); Radiology, Stanford University, Stanford, California (United States); GE Healthcare, Haifa (Israel); GE Global Research, Niskayuna, New York (United States); Biomedical Engineering, Technion IIT, Haifa (Israel); GE Global Research, Niskayuna, New York (United States)

    2012-11-28

    Phase aberrations and attenuations caused by bone can defocus HIFU in the brain and organs behind the ribcage. To refocus the beam, MR-ARFI can be used to measure tissue displacements created by each element in the transducer, and optimize driving signal delays and amplitudes. We introduce a new MR-ARFI-based autofocusing method that requires many fewer image acquisitions than current methods. The method is validated in simulations of bone and brain HIFU transducers, and compared to a conventional method.

  9. Practical Study and Solutions Adapted For The Road Noise In The Algiers City

    Iddir, R.; Boukhaloua, N.; Saadi, T.

    At the present hour where the city spreads on a big space, the road network devel- opment was a following logical of this movement. Generating a considerable impact thus on the environment. This last is a resulting open system of the interaction be- tween the man and the nature, it's affected all side by the different means of transport and by their increasing demand of mobility. The contemporary city development be- got problems bound to the environment and among it : The road noise. This last is a complex phenomenon, essentially by reason of its humans sensory effects, its impact on the environment is considerable, this one concerns the life quality directly, mainly in population zones to strong density. The resonant pollution reached its paroxysm; the road network of Algiers is not conceived to satisfy requirements in resonant pol- lution matter. For it arrangements soundproof should be adapted in order to face of it these new requirements in matter of the acoustic comfort. All these elements drove to the process aiming the attenuation of the hindrance caused by the road traffic and it by actions essentially aiming: vehicles, the structure of the road and the immediate envi- ronment of the system road - structure. From these results, we note that the situation in resonant nuisance matter in this zone with strong traffic is disturbing, and especially on the residents health.

  10. A de-noising algorithm based on wavelet threshold-exponential adaptive window width-fitting for ground electrical source airborne transient electromagnetic signal

    Ji, Yanju; Li, Dongsheng; Yu, Mingmei; Wang, Yuan; Wu, Qiong; Lin, Jun

    2016-05-01

    The ground electrical source airborne transient electromagnetic system (GREATEM) on an unmanned aircraft enjoys considerable prospecting depth, lateral resolution and detection efficiency, etc. In recent years it has become an important technical means of rapid resources exploration. However, GREATEM data are extremely vulnerable to stationary white noise and non-stationary electromagnetic noise (sferics noise, aircraft engine noise and other human electromagnetic noises). These noises will cause degradation of the imaging quality for data interpretation. Based on the characteristics of the GREATEM data and major noises, we propose a de-noising algorithm utilizing wavelet threshold method and exponential adaptive window width-fitting. Firstly, the white noise is filtered in the measured data using the wavelet threshold method. Then, the data are segmented using data window whose step length is even logarithmic intervals. The data polluted by electromagnetic noise are identified within each window based on the discriminating principle of energy detection, and the attenuation characteristics of the data slope are extracted. Eventually, an exponential fitting algorithm is adopted to fit the attenuation curve of each window, and the data polluted by non-stationary electromagnetic noise are replaced with their fitting results. Thus the non-stationary electromagnetic noise can be effectively removed. The proposed algorithm is verified by the synthetic and real GREATEM signals. The results show that in GREATEM signal, stationary white noise and non-stationary electromagnetic noise can be effectively filtered using the wavelet threshold-exponential adaptive window width-fitting algorithm, which enhances the imaging quality.

  11. Blood coagulation using High Intensity Focused Ultrasound (HIFU)

    Nguyen, Phuc V.; Oh, Junghwan; Kang, Hyun Wook

    2014-03-01

    High Intensity Focused Ultrasound (HIFU) technology provides a feasible method of achieving thermal coagulation during surgical procedures. One of the potential clinical benefits of HIFU can induce immediate hemostasis without suturing. The objective of this study was to investigate the efficiency of a HIFU system for blood coagulation on severe vascular injury. ngHIFU treatment was implemented immediately after bleeding in artery. The ultrasound probe was made of piezoelectric material, generating a central frequency of 2.0 MHz as well as an ellipsoidal focal spot of 2 mm in lateral dimension and 10 mm in axial dimension. Acoustic coagulation was employed on a perfused chicken artery model in vitro. A surgical incision (1 to 2 mm long) was made with a scapel on the arterial wall, and heparinized autologous blood was made to leak out from the incision with a syringe pump. A total of 5 femoral artery incisions was treated with the HIFU beam. The intensity of 4500 W/cm2 at the focus was applied for all treatments. Complete hemostasis was achieved in all treatments, along with the treatment times of 25 to 50 seconds. The estimated intraoperative blood loss was from 2 to 5 mL. The proposed HIFU system may provide an effective method for immediate blood coagulation for arteries and veins in clinical applications.

  12. Noise-driven switching between limit cycles and adaptability in a small-dimensional excitable network with balanced coupling

    We study the adaptability of coupled non-linear oscillators to external forcing by using a system of globally coupled FitzHugh-Nagumo equations. Each unit is either excitatory or inhibitory. If the numbers of units of both types are in a specific relation (balanced coupling), we observe the presence of multistable oscillatory states with different excitation or firing rates. In the presence of noise, there is noise-driven switching between these states. The selection between higher- and lower-frequency oscillitons depends on the input, which results in increasing coherence between the periodic input and the system's output

  13. Noise-driven switching between limit cycles and adaptability in a small-dimensional excitable network with balanced coupling

    We study a system of globally coupled FitzHugh-Nagumo equations. Each unit is either excitatory or inhibitory. If the numbers of units of both types are in a specific ratio, we observe the presence of multistable oscillatory states with different excitation or firing rates. In the presence of noise, there is noise-driven switching between these states and the resultant firing pattern is long-range correlated. The choice between higher and lower frequency oscillations depends on the input, which results in increasing adaptability of the system's output to the periodic input

  14. CT urography in the urinary bladder: To compare excretory phase images using a low noise index and a high noise index with adaptive noise reduction filter

    Background: Although CT urography (CTU) is widely used for the evaluation of the entire urinary tract, the most important drawback is the radiation exposure. Purpose: To evaluate the effect of a noise reduction filter (NRF) using a phantom and to quantitatively and qualitatively compare excretory phase (EP) images using a low noise index (NI) with those using a high NI and postprocessing NRF (pNRF). Material and Methods: Each NI value was defined for a slice thickness of 5 mm, and reconstructed images with a slice thickness of 1.25 mm were assessed. Sixty patients who were at high risk of developing bladder tumors (BT) were divided into two groups according to whether their EP images were obtained using an NI of 9.88 (29 patients; group A) or an NI of 20 and pNRF (31 patients; group B). The CT dose index volume (CTDIvol) and the contrast-to-noise ratio (CNR) of the bladder with respect to the anterior pelvic fat were compared in both groups. Qualitative assessment of the urinary bladder for image noise, sharpness, streak artifacts, homogeneity, and the conspicuity of polypoid or sessile-shaped BTs with a short-axis diameter greater than 10 mm was performed using a 3-point scale. Results: The phantom study showed noise reduction of approximately 40% and 76% dose reduction between group A and group B. CTDIvol demonstrated a 73% reduction in group B (4.6 ± 1.1 mGy) compared with group A (16.9 ± 3.4 mGy). The CNR value was not significantly different (P = 0.60) between group A (16.1 ± 5.1) and group B (16.6 ± 7.6). Although group A was superior (P < 0.01) to group B with regard to image noise, other qualitative analyses did not show significant differences. Conclusion: EP images using a high NI and pNRF were quantitatively and qualitatively comparable to those using a low NI, except with regard to image noise

  15. Rician noise reduction in magnetic resonance images using adaptive non-local mean and guided image filtering

    Mahmood, Muhammad Tariq; Chu, Yeon-Ho; Choi, Young-Kyu

    2016-06-01

    This paper proposes a Rician noise reduction method for magnetic resonance (MR) images. The proposed method is based on adaptive non-local mean and guided image filtering techniques. In the first phase, a guidance image is obtained from the noisy image through an adaptive non-local mean filter. Sobel operators are applied to compute the strength of edges which is further used to control the spread of the kernel in non-local mean filtering. In the second phase, the noisy and the guidance images are provided to the guided image filter as input to restore the noise-free image. The improved performance of the proposed method is investigated using the simulated and real data sets of MR images. Its performance is also compared with the previously proposed state-of-the art methods. Comparative analysis demonstrates the superiority of the proposed scheme over the existing approaches.

  16. A multichannel nonlinear adaptive noise canceller based on generalized FLANN for fetal ECG extraction

    Ma, Yaping; Xiao, Yegui; Wei, Guo; Sun, Jinwei

    2016-01-01

    In this paper, a multichannel nonlinear adaptive noise canceller (ANC) based on the generalized functional link artificial neural network (FLANN, GFLANN) is proposed for fetal electrocardiogram (FECG) extraction. A FIR filter and a GFLANN are equipped in parallel in each reference channel to respectively approximate the linearity and nonlinearity between the maternal ECG (MECG) and the composite abdominal ECG (AECG). A fast scheme is also introduced to reduce the computational cost of the FLANN and the GFLANN. Two (2) sets of ECG time sequences, one synthetic and one real, are utilized to demonstrate the improved effectiveness of the proposed nonlinear ANC. The real dataset is derived from the Physionet non-invasive FECG database (PNIFECGDB) including 55 multichannel recordings taken from a pregnant woman. It contains two subdatasets that consist of 14 and 8 recordings, respectively, with each recording being 90 s long. Simulation results based on these two datasets reveal, on the whole, that the proposed ANC does enjoy higher capability to deal with nonlinearity between MECG and AECG as compared with previous ANCs in terms of fetal QRS (FQRS)-related statistics and morphology of the extracted FECG waveforms. In particular, for the second real subdataset, the F1-measure results produced by the PCA-based template subtraction (TSpca) technique and six (6) single-reference channel ANCs using LMS- and RLS-based FIR filters, Volterra filter, FLANN, GFLANN, and adaptive echo state neural network (ESN a ) are 92.47%, 93.70%, 94.07%, 94.22%, 94.90%, 94.90%, and 95.46%, respectively. The same F1-measure statistical results from five (5) multi-reference channel ANCs (LMS- and RLS-based FIR filters, Volterra filter, FLANN, and GFLANN) for the second real subdataset turn out to be 94.08%, 94.29%, 94.68%, 94.91%, and 94.96%, respectively. These results indicate that the ESN a and GFLANN perform best, with the ESN a being slightly better than the GFLANN but about four times more

  17. EEG/ERP adaptive noise canceller design with controlled search space (CSS) approach in cuckoo and other optimization algorithms.

    Ahirwal, M K; Kumar, Anil; Singh, G K

    2013-01-01

    This paper explores the migration of adaptive filtering with swarm intelligence/evolutionary techniques employed in the field of electroencephalogram/event-related potential noise cancellation or extraction. A new approach is proposed in the form of controlled search space to stabilize the randomness of swarm intelligence techniques especially for the EEG signal. Swarm-based algorithms such as Particles Swarm Optimization, Artificial Bee Colony, and Cuckoo Optimization Algorithm with their variants are implemented to design optimized adaptive noise canceler. The proposed controlled search space technique is tested on each of the swarm intelligence techniques and is found to be more accurate and powerful. Adaptive noise canceler with traditional algorithms such as least-mean-square, normalized least-mean-square, and recursive least-mean-square algorithms are also implemented to compare the results. ERP signals such as simulated visual evoked potential, real visual evoked potential, and real sensorimotor evoked potential are used, due to their physiological importance in various EEG studies. Average computational time and shape measures of evolutionary techniques are observed 8.21E-01 sec and 1.73E-01, respectively. Though, traditional algorithms take negligible time consumption, but are unable to offer good shape preservation of ERP, noticed as average computational time and shape measure difference, 1.41E-02 sec and 2.60E+00, respectively. PMID:24407307

  18. Histopathological changes associated with high intensity focused ultrasound (HIFU) treatment for localised adenocarcinoma of the prostate

    van Leenders, G J L H; Beerlage, H; Ruijter, E.; de la Rosette, J J M C H; van de Kaa, C A

    2000-01-01

    Aims—Investigation of the histopathological changes in prostatectomy specimens of patients with prostate cancer after high intensity focused ultrasound (HIFU) and identification of immunohistochemical markers for tissue damage after HIFU treatment.

  19. Elimination of therapeutic ultrasound noise from pre-beamformed RF data in ultrasound imaging for ultrasound-guided high-intensity focused ultrasound treatment

    Takagi, Ryo; Goto, Kota; Jimbo, Hayato; Matsuura, Keiko; Iwasaki, Ryosuke; Umemura, Shin-ichiro; Yoshizawa, Shin

    2015-07-01

    In conventional ultrasonic monitoring of high-intensity focused ultrasound (HIFU) treatment, a significant interval between consecutive HIFU shots is set for monitoring target tissue to avoid the interference of HIFU noise with RF echo signals. Thus, it is difficult to detect changes in tissue on the order of milliseconds, which are required to dynamically control the HIFU exposure. In this study, a new filtering method to eliminate the HIFU noise in the RF signals before beamforming is proposed. The CW response was estimated from RF signals with no pulse response to the imaging exposure, and the estimated CW response was subtracted from the entire RF signal to selectively eliminate the HIFU noise for each channel of the array probe before dynamic focusing was applied. The HIFU noise was selectively eliminated by this method when it existed. The results imply that the proposed filtering method is useful for true real-time detection of changes in tissue due to thermal coagulation during HIFU exposure.

  20. Combination of the transurethral resection and prostate HIFU ablation at treatment of the localized cancer

    Popkov V.M.; Fomkin R.N.; Blyumberg B.l.; Shatylko T.V.; Sedova L.N.; Abramova E.P.

    2014-01-01

    Research objective: to estimate results of treatment of patients with the localized form of a cancer of a prostate at a combination of a transurethral resection (TURP) and HIFU of an ablation. Objects and research methods: From February, 2009 to February, 2014 of 100 patients with the localized form of a cancer of a prostate were selected for research: 26 patients were included into HIFU and 74 group in group of the combined treatment (TURP+HIFU). Selection criteria for HIFU ablation were ...

  1. Feasibility of monitoring HIFU prostate cancer therapy using elastography

    Souchon, Remi; Chapelon, Jean Y.; Bertrand, Michel J.; Kallel, Faouzi; Ophir, Jonathan

    2001-05-01

    The objective of this study is to investigate the feasibility of elastographic monitoring of High Intensity Focused Ultrasound (HIFU) therapy of prostate cancer. Elastography is an imaging technique based on strain estimation in soft tissues under quasi-static compression. Since pathological tissues and HIFU-induced lesions exhibit different elastic properties than normal tissues, elastography is potentially able to achieve these goals. An ultrasound scanner was connected to a PC to acquire RF images. This setup is compatible with a HIFU device used for prostate cancer therapy by transrectal route. The therapy transducer and the biplane-imaging probe are covered with a balloon filled with a coupling liquid. Compression of the prostate is applied by inflating the balloon, while imaging sector scans of the prostate. In-vivo elastograms of the prostate were acquired before HIFU treatment. Problems inherent to in-vivo acquisitions are reported, such as undesired tangential displacements during the radial compression. This study shows the potential for in-vivo elastogram acquisition of HIFU-induced lesions in the human prostate.

  2. High-Intensity Focused Ultrasound (HIFU) in Localized Prostate Cancer Treatment

    High-intensity focused ultrasound (HIFU) applies high-intensity focused ultrasound energy to locally heat and destroy diseased or damaged tissue through ablation. This study intended to review HIFU to explain the fundamentals of HIFU, evaluate the evidence concerning the role of HIFU in the treatment of prostate cancer (PC), review the technologies used to perform HIFU and the published clinical literature regarding the procedure as a primary treatment for PC. Studies addressing HIFU in localized PC were identified in a search of internet scientific databases. The analysis of outcomes was limited to journal articles written in English and published between 2000 and 2013. HIFU is a non-invasive approach that uses a precisely delivered ultrasound energy to achieve tumor cell necrosis without radiation or surgical excision. In current urological oncology, HIFU is used clinically in the treatment of PC. Clinical research on HIFU therapy for localized PC began in the 1990s, and the majority of PC patients were treated with the Ablatherm device. HIFU treatment for localized PC can be considered as an alternative minimally invasive therapeutic modality for patients who are not candidates for radical prostatectomy. Patients with lower pre-HIFU PSA level and favourable pathologic Gleason score seem to present better oncologic outcomes. Future advances in technology and safety will undoubtedly expand the HIFU role in this indication as more of patient series are published, with a longer follow-up period

  3. Implementation of Adaptive Filter Structures on a Fixed Point Signal Processor for Acoustical Noise Reduction

    Chunduri, Krishna Chaitanya; Gutti, Chalapathi

    2005-01-01

    The problem of controlling the noise level in the environment has been the focus of a tremendous amount of research over the years. Active Noise Cancellation (ANC) is one such approach that has been proposed for reduction of steady state noise. ANC refers to an electromechanical or electro acoustic technique of canceling an acoustic disturbance to yield a quieter environment. The basic principle of ANC is to introduce a canceling “anti-noise” signal that has the same amplitude but the exact o...

  4. An adaptive integrated algorithm for noninvasive fetal ECG separation and noise reduction based on ICA-EEMD-WS.

    Liu, Guangchen; Luan, Yihui

    2015-11-01

    High-resolution fetal electrocardiogram (FECG) plays an important role in assisting physicians to detect fetal changes in the womb and to make clinical decisions. However, in real situations, clear FECG is difficult to extract because it is usually overwhelmed by the dominant maternal ECG and other contaminated noise such as baseline wander, high-frequency noise. In this paper, we proposed a novel integrated adaptive algorithm based on independent component analysis (ICA), ensemble empirical mode decomposition (EEMD), and wavelet shrinkage (WS) denoising, denoted as ICA-EEMD-WS, for FECG separation and noise reduction. First, ICA algorithm was used to separate the mixed abdominal ECG signal and to obtain the noisy FECG. Second, the noise in FECG was reduced by a three-step integrated algorithm comprised of EEMD, useful subcomponents statistical inference and WS processing, and partial reconstruction for baseline wander reduction. Finally, we evaluate the proposed algorithm using simulated data sets. The results indicated that the proposed ICA-EEMD-WS outperformed the conventional algorithms in signal denoising. PMID:26429348

  5. Adaptive Volterra filter with continuous lp-norm using a logarithmic cost for nonlinear active noise control

    Lu, Lu; Zhao, Haiquan

    2016-03-01

    The filtered-x least mean lp-norm (FxLMP) algorithm is proven to be useful for nonlinear active noise control (NANC) systems. However, its performance deteriorates when the impulsive noises are presented in NANC systems. To surmount this shortcoming, a new nonlinear adaptive algorithm based on Volterra expansion model (VFxlogLMP) is developed in this paper, which is derived by minimizing the lp-norm of logarithmic cost. It is found that the FxLMP and VFxlogLMP require to select an appropriate value of p according to the prior information on noise characteristics, which prohibit their practical applications. Based on VFxlogLMP algorithm, we proposed a continuous lp-norm algorithm with logarithmic cost (VFxlogCLMP), which does not need the parameter selection and thresholds estimation. Benefiting from the various error norms for 1≤p≤2, it remains the robustness of VFxlogLMP. Moreover, the convergence behavior of VFxlogCLMP for moving average secondary paths and stochastic input signals is performed. Compared to the existing algorithms, two versions of the proposed algorithms have much better convergence and stability in impulsive noise environments.

  6. Wireless rake-receiver using adaptive filter with a family of partial update algorithms in noise cancellation applications

    Fayadh, Rashid A.; Malek, F.; Fadhil, Hilal A.; Aldhaibani, Jaafar A.; Salman, M. K.; Abdullah, Farah Salwani

    2015-05-01

    For high data rate propagation in wireless ultra-wideband (UWB) communication systems, the inter-symbol interference (ISI), multiple-access interference (MAI), and multiple-users interference (MUI) are influencing the performance of the wireless systems. In this paper, the rake-receiver was presented with the spread signal by direct sequence spread spectrum (DS-SS) technique. The adaptive rake-receiver structure was shown with adjusting the receiver tap weights using least mean squares (LMS), normalized least mean squares (NLMS), and affine projection algorithms (APA) to support the weak signals by noise cancellation and mitigate the interferences. To minimize the data convergence speed and to reduce the computational complexity by the previous algorithms, a well-known approach of partial-updates (PU) adaptive filters were employed with algorithms, such as sequential-partial, periodic-partial, M-max-partial, and selective-partial updates (SPU) in the proposed system. The simulation results of bit error rate (BER) versus signal-to-noise ratio (SNR) are illustrated to show the performance of partial-update algorithms that have nearly comparable performance with the full update adaptive filters. Furthermore, the SPU-partial has closed performance to the full-NLMS and full-APA while the M-max-partial has closed performance to the full-LMS updates algorithms.

  7. Noise Reduction and Gap Filling of fAPAR Time Series Using an Adapted Local Regression Filter

    Álvaro Moreno

    2014-08-01

    Full Text Available Time series of remotely sensed data are an important source of information for understanding land cover dynamics. In particular, the fraction of absorbed photosynthetic active radiation (fAPAR is a key variable in the assessment of vegetation primary production over time. However, the fAPAR series derived from polar orbit satellites are not continuous and consistent in space and time. Filtering methods are thus required to fill in gaps and produce high-quality time series. This study proposes an adapted (iteratively reweighted local regression filter (LOESS and performs a benchmarking intercomparison with four popular and generally applicable smoothing methods: Double Logistic (DLOG, smoothing spline (SSP, Interpolation for Data Reconstruction (IDR and adaptive Savitzky-Golay (ASG. This paper evaluates the main advantages and drawbacks of the considered techniques. The results have shown that ASG and the adapted LOESS perform better in recovering fAPAR time series over multiple controlled noisy scenarios. Both methods can robustly reconstruct the fAPAR trajectories, reducing the noise up to 80% in the worst simulation scenario, which might be attributed to the quality control (QC MODIS information incorporated into these filtering algorithms, their flexibility and adaptation to the upper envelope. The adapted LOESS is particularly resistant to outliers. This method clearly outperforms the other considered methods to deal with the high presence of gaps and noise in satellite data records. The low RMSE and biases obtained with the LOESS method (|rMBE| < 8%; rRMSE < 20% reveals an optimal reconstruction even in most extreme situations with long seasonal gaps. An example of application of the LOESS method to fill in invalid values in real MODIS images presenting persistent cloud and snow coverage is also shown. The LOESS approach is recommended in most remote sensing applications, such as gap-filling, cloud-replacement, and observing temporal

  8. Experimental ablation of the pancreas with high intensity focused ultrasound (HIFU in a porcine model

    Biao Xie, Yu-Yuan Li, Lin Jia, Yu-Qiang Nie, Hong Du, Shu-Man Jiang

    2011-01-01

    Full Text Available The aim of this study was to determine the feasibility and safety of high intensity focused ultrasound's (HIFU in pancreatic diseases. Twelve pigs were divided into three groups. The pancreases of pigs in Group A were ablated directly with HIFU, but those in Group B and C ablated by extracorporeal HIFU. The pigs in Group C were sacrificed at day 7 after HIFU. Serological parameters were determined pre-operation and post-operation. The entire pancreas was removed for histological examination. Each animal tolerate the HIFU ablation well. The complete necrosis was observed in targeted regions. The margins of the necrotic regions were clearly delineated from the surrounding normal tissues. Infiltration of inflammatory cells and phorocytosis on the boundary were found in group C. Blood and urine amylase levels were relatively steady after HIFU. No acute pancreatitis or severe complications occurred. In conclusion, HIFU ablation on the pancreas was safe and effective in experimental pigs.

  9. HIFU Monitoring and Control with Dual-Mode Ultrasound Arrays

    Casper, Andrew Jacob

    The biological effects of high-intensity focused ultrasound (HIFU) have been known and studied for decades. HIFU has been shown capable of treating a wide variety of diseases and disorders. However, despite its demonstrated potential, HIFU has been slow to gain clinical acceptance. This is due, in part, to the difficulty associated with robustly monitoring and controlling the delivery of the HIFU energy. The non-invasive nature of the surgery makes the assessment of treatment progression difficult, leading to long treatment times and a significant risk of under treatment. This thesis research develops new techniques and systems for robustly monitoring HIFU therapies for the safe and efficacious delivery of the intended treatment. Systems and algorithms were developed for the two most common modes of HIFU delivery systems: single-element and phased array applicators. Delivering HIFU with a single element transducer is a widely used technique in HIFU therapies. The simplicity of a single element offers many benefits in terms of cost and overall system complexity. Typical monitoring schemes rely on an external device (e.g. diagnostic ultrasound or MRI) to assess the progression of therapy. The research presented in this thesis explores using the same element to both deliver and monitor the HIFU therapy. The use of a dual-mode ultrasound transducer (DMUT) required the development of an FPGA based single-channel arbitrary waveform generator and high-speed data acquisition unit. Data collected from initial uncontrolled ablations led to the development of monitoring and control algorithms which were implemented directly on the FPGA. Close integration between the data acquisition and arbitrary waveform units allowed for fast, low latency control over the ablation process. Results are presented that demonstrate control of HIFU therapies over a broad range of intensities and in multiple in vitro tissues. The second area of investigation expands the DMUT research to an

  10. Spatiotemporal filtering of MR-temperature artifacts arising from bowel motion during transurethral MR-HIFU

    Purpose: Transurethral MR-HIFU is a minimally invasive image-guided treatment for localized prostate cancer that enables precise targeting of tissue within the gland. The treatment is performed within a clinical MRI to obtain real-time MR thermometry used as an active feedback to control the spatial heating pattern in the prostate and to monitor for potential damage to surrounding tissues. This requires that the MR thermometry measurements are an accurate representation of the true tissue temperature. The proton resonance frequency shift thermometry method used is sensitive to tissue motion and changes in the local magnetic susceptibility that can be caused by the motion of air bubbles in the rectum, which can impact the performance of transurethral MR-HIFU in these regions of the gland. Methods: A method is proposed for filtering of temperature artifacts based on the temporal variance of the temperature, using empirical and dynamic positional knowledge of the ultrasonic heating beam, and an estimation of the measurement noise. A two-step correction strategy is introduced which eliminates artifact-detected temperature variations while keeping the noise level low through spatial averaging. Results: The filter has been evaluated by postprocessing data from five human transurethral ultrasound treatments. The two-step correction process led to reduced final temperature standard deviation in the prostate and rectum areas where the artifact was located, without negatively affecting areas distal to the artifact. The performance of the filter was also found to be consistent across all six of the data sets evaluated. The evaluation of the detection criterion parameter M determined that a value of M = 3 achieves a conservative filter with minimal loss of spatial resolution during the process. Conclusions: The filter was able to remove most artifacts due to the presence of moving air bubbles in the rectum during transurethral MR-HIFU. A quantitative estimation of the filter

  11. Spatiotemporal filtering of MR-temperature artifacts arising from bowel motion during transurethral MR-HIFU

    Schmitt, Alain, E-mail: aschmitt@sri.utoronto.ca [Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5 (Canada); Mougenot, Charles [Philips Healthcare, 281 Hillmount Road, Markham, Ontario L6C 2S3 (Canada); Chopra, Rajiv [Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canadaand Department of Radiology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9061 (United States)

    2014-11-01

    Purpose: Transurethral MR-HIFU is a minimally invasive image-guided treatment for localized prostate cancer that enables precise targeting of tissue within the gland. The treatment is performed within a clinical MRI to obtain real-time MR thermometry used as an active feedback to control the spatial heating pattern in the prostate and to monitor for potential damage to surrounding tissues. This requires that the MR thermometry measurements are an accurate representation of the true tissue temperature. The proton resonance frequency shift thermometry method used is sensitive to tissue motion and changes in the local magnetic susceptibility that can be caused by the motion of air bubbles in the rectum, which can impact the performance of transurethral MR-HIFU in these regions of the gland. Methods: A method is proposed for filtering of temperature artifacts based on the temporal variance of the temperature, using empirical and dynamic positional knowledge of the ultrasonic heating beam, and an estimation of the measurement noise. A two-step correction strategy is introduced which eliminates artifact-detected temperature variations while keeping the noise level low through spatial averaging. Results: The filter has been evaluated by postprocessing data from five human transurethral ultrasound treatments. The two-step correction process led to reduced final temperature standard deviation in the prostate and rectum areas where the artifact was located, without negatively affecting areas distal to the artifact. The performance of the filter was also found to be consistent across all six of the data sets evaluated. The evaluation of the detection criterion parameter M determined that a value of M = 3 achieves a conservative filter with minimal loss of spatial resolution during the process. Conclusions: The filter was able to remove most artifacts due to the presence of moving air bubbles in the rectum during transurethral MR-HIFU. A quantitative estimation of the filter

  12. Feasibility of real-time treatment feedback using novel filter for eliminating therapeutic ultrasound noise with high-speed ultrasonic imaging in ultrasound-guided high-intensity focused ultrasound treatment

    Takagi, Ryo; Jimbo, Hayato; Iwasaki, Ryosuke; Tomiyasu, Kentaro; Yoshizawa, Shin; Umemura, Shin-ichiro

    2016-07-01

    In the conventional ultrasonic monitoring of high-intensity focused ultrasound (HIFU) treatment, a significant interval between HIFU shots is required when monitoring target tissue to avoid interference between HIFU noise and RF echo signals. In our previous study, a new filtering method to eliminate only HIFU noise while maintaining tissue signals intact was proposed, and it was shown that the thermal coagulation could be detected during simultaneous HIFU irradiation through off-line processing. In this study, the filtering method and a real-time coagulation detection algorithm were implemented in an ultrasound imaging system, whose use for sequential exposure with multiple foci was demonstrated similarly to a commercial HIFU ablation system. The coagulation was automatically detected by the proposed method during real-time simultaneous HIFU irradiation, and the HIFU exposure time was controlled according to the changes in the tissue. The results imply that ultrasonic monitoring with the filtering and detection methods is useful for true real-time detection of changes in the tissue due to thermal coagulation during HIFU exposure.

  13. dc SQUID electronics based on adaptive noise cancellation and a high open-loop gain controller

    A low-noise SQUID readout electronics with a high slew rate and an automatic gain control feature has been developed. Flux noise levels of 5x10-7Φ0/√Hz at 1 kHz and 2x10-6Φ0/√Hz at 1 Hz have been measured with this readout scheme. The system tolerates sinusoidal disturbances having amplitudes up to 140 Φ0 at 1 kHz without loosing lock. The electronics utilizes a cooled GaAs FET to control the cancellation of the voltage noise of the room temperature amplifier, a PI3/2 controller to provide a high open-loop gain at low frequencies, and a square-wave flux and offset voltage modulation to enable automatic control of the noise reduction. The cutoff frequency of the flux-locked-loop is 300 kHz and the feedback gain is more than 130 dB at 10 Hz. (orig.)

  14. An analytical solution for improved HIFU SAR estimation

    Accurate determination of the specific absorption rates (SARs) present during high intensity focused ultrasound (HIFU) experiments and treatments provides a solid physical basis for scientific comparison of results among HIFU studies and is necessary to validate and improve SAR predictive software, which will improve patient treatment planning, control and evaluation. This study develops and tests an analytical solution that significantly improves the accuracy of SAR values obtained from HIFU temperature data. SAR estimates are obtained by fitting the analytical temperature solution for a one-dimensional radial Gaussian heating pattern to the temperature versus time data following a step in applied power and evaluating the initial slope of the analytical solution. The analytical method is evaluated in multiple parametric simulations for which it consistently (except at high perfusions) yields maximum errors of less than 10% at the center of the focal zone compared with errors up to 90% and 55% for the commonly used linear method and an exponential method, respectively. For high perfusion, an extension of the analytical method estimates SAR with less than 10% error. The analytical method is validated experimentally by showing that the temperature elevations predicted using the analytical method's SAR values determined for the entire 3D focal region agree well with the experimental temperature elevations in a HIFU-heated tissue-mimicking phantom. (paper)

  15. Experimentelle Untersuchungen zur nichtinvasiven Gewebeablation durch hochenergetischen fokussierten Ultraschall (HIFU)

    Peters, Kristina

    2007-01-01

    Es wurden am neu bewerteten porcinen Nierenmodell mittels hochintensivem fokussierten Ultraschall mit verschiedenen HIFU Behandlungsgeräten Gewebeareale abladiert und die Effekte mittels histologischen Verfahren, Magnetresonanztherapie, Angiographie und einem Ultraschallphantom evaluiert. Es konnte gezeigt werden, dass es bei geeigneter Einstellung möglich ist klinisch relevante Gewebsvolumina zuverlässig, irreversibel zu zerstören.

  16. Real-time Monitoring of High Intensity Focused Ultrasound (HIFU) Ablation of In Vitro Canine Livers Using Harmonic Motion Imaging for Focused Ultrasound (HMIFU).

    Grondin, Julien; Payen, Thomas; Wang, Shutao; Konofagou, Elisa E

    2015-01-01

    Harmonic Motion Imaging for Focused Ultrasound (HMIFU) is a technique that can perform and monitor high-intensity focused ultrasound (HIFU) ablation. An oscillatory motion is generated at the focus of a 93-element and 4.5 MHz center frequency HIFU transducer by applying a 25 Hz amplitude-modulated signal using a function generator. A 64-element and 2.5 MHz imaging transducer with 68kPa peak pressure is confocally placed at the center of the HIFU transducer to acquire the radio-frequency (RF) channel data. In this protocol, real-time monitoring of thermal ablation using HIFU with an acoustic power of 7 W on canine livers in vitro is described. HIFU treatment is applied on the tissue during 2 min and the ablated region is imaged in real-time using diverging or plane wave imaging up to 1,000 frames/second. The matrix of RF channel data is multiplied by a sparse matrix for image reconstruction. The reconstructed field of view is of 90° for diverging wave and 20 mm for plane wave imaging and the data are sampled at 80 MHz. The reconstruction is performed on a Graphical Processing Unit (GPU) in order to image in real-time at a 4.5 display frame rate. 1-D normalized cross-correlation of the reconstructed RF data is used to estimate axial displacements in the focal region. The magnitude of the peak-to-peak displacement at the focal depth decreases during the thermal ablation which denotes stiffening of the tissue due to the formation of a lesion. The displacement signal-to-noise ratio (SNRd) at the focal area for plane wave was 1.4 times higher than for diverging wave showing that plane wave imaging appears to produce better displacement maps quality for HMIFU than diverging wave imaging. PMID:26556647

  17. Wavelet domain adaptive filtering algorithm for removing the seamless pipe noise contained in the magnetic flux leakage data

    Han Wenhua; Que Peiwen

    2006-01-01

    With the widespread application and fast development of gas and oil pipeline network in China, the pipeline inspection technology has been used more extensively. The magnetic flux leakage (MFL) method has established itself as the most widely used in-line inspection technique for the evaluation of gas and oil pipelines. The MFL data obtained from seamless pipeline inspection is usually contaminated by the seamless pipe noise (SPN). SPN can in some cases completely mask MFL signals from certain type of defects,and therefore considerably reduces the detectability of the defect signals. In this paper, a new de-noising algorithm called wavelet domain adaptive filtering is proposed for removing the SPN contained in the MFL data. The new algorithm results from combining the wavelet transform with the adaptive filtering technique. Results from application of the proposed algorithm to the MFL data from field tests show that the proposed algorithm has good performance and considerably improves the detectability of the defect signals in the MFL data.

  18. Integrated WiFi/PDR/Smartphone Using an Adaptive System Noise Extended Kalman Filter Algorithm for Indoor Localization

    Xin Li

    2016-02-01

    Full Text Available Wireless signal strength is susceptible to the phenomena of interference, jumping, and instability, which often appear in the positioning results based on Wi-Fi field strength fingerprint database technology for indoor positioning. Therefore, a Wi-Fi and PDR (pedestrian dead reckoning real-time fusion scheme is proposed in this paper to perform fusing calculation by adaptively determining the dynamic noise of a filtering system according to pedestrian movement (straight or turning, which can effectively restrain the jumping or accumulation phenomena of wireless positioning and the PDR error accumulation problem. Wi-Fi fingerprint matching typically requires a quite high computational burden: To reduce the computational complexity of this step, the affinity propagation clustering algorithm is adopted to cluster the fingerprint database and integrate the information of the position domain and signal domain of respective points. An experiment performed in a fourth-floor corridor at the School of Environment and Spatial Informatics, China University of Mining and Technology, shows that the traverse points of the clustered positioning system decrease by 65%–80%, which greatly improves the time efficiency. In terms of positioning accuracy, the average error is 4.09 m through the Wi-Fi positioning method. However, the positioning error can be reduced to 2.32 m after integration of the PDR algorithm with the adaptive noise extended Kalman filter (EKF.

  19. Multi-microphone adaptive noise reduction strategies for coordinated stimulation in bilateral cochlear implant devices

    Kokkinakis, Kostas; Loizou, Philipos C.

    2010-01-01

    Bilateral cochlear implant (BI-CI) recipients achieve high word recognition scores in quiet listening conditions. Still, there is a substantial drop in speech recognition performance when there is reverberation and more than one interferers. BI-CI users utilize information from just two directional microphones placed on opposite sides of the head in a so-called independent stimulation mode. To enhance the ability of BI-CI users to communicate in noise, the use of two computationally inexpensi...

  20. Variational Bayesian Adaptation of Noise Covariances in Non-Linear Kalman Filtering

    Hartikainen, Simo Särkkä Jouni

    2013-01-01

    This paper is considered with joint estimation of state and time-varying noise covariance matrices in non-linear stochastic state space models. We present a variational Bayes and Gaussian filtering based algorithm for efficient computation of the approximate filtering posterior distributions. The Gaussian filtering based formulation of the non-linear state space model computation allows usage of efficient Gaussian integration methods such as unscented transform, cubature integration and Gauss...

  1. HIFU and Chemotherapy Synergistic Inhibitory Effect on Dunning AT2 Tumour-Bearing Rats

    Curiel, Laura; Paparel, Philipe; Chesnais, Sabrina; Gelet, Albert; Chapelon, Jean-Yves

    2005-03-01

    Since there is no 100% satisfactory treatment for localized prostate cancer in patients presenting symptoms representing a poor prognosis (stage T3, high Gleason score, PSA level greater than 15 ng/ml, etc.), this study aimed to evaluate the therapeutic and synergistic inhibition effects of using High Intensity Focused Ultrasound (HIFU) in combination with chemotherapy (Taxane + Estramustine). Forty-one Dunning AT2 tumour-bearing Copenhagen rats receiving HIFU and/or chemotherapy were divided into four groups: control group; chemotherapy group; HIFU group; and HIFU-chemotherapy combined group. Increase in the tumour volume was observed over 3 weeks and the tumour volume doubling time was evaluated. Growth curves for each group were then plotted and statistically evaluated. HIFU treatment combined with Taxane + Estramusine was found to have a significant synergistic effect; on day 30, the distribution of tumour volume relative to the treatment group was significantly different (p = 0.0007). The control group volumes were significantly greater than those of the chemotherapy-only (p = 0.006) or HIFU-only group (p = 0.006). The greatest difference was observed between the chemotherapy plus HIFU combined group and the control group. Additionally, tumour-doubling times were 7.7 days for the control group, 13.2 days for the HIFU-only group, and 31.2 days for the chemotherapy plus HIFU group. The differences in tumour growth rates between the chemotherapy plus HIFU combined group and a chemotherapy-only + HIFU-only grouping was 3.8% (p = 0.0020). Thus, the combined chemotherapy plus HIFU treatment was clearly more effective in reducing the tumour size than HIFU only or chemotherapy only, which indicates a synergy between the two types of treatment. Our results suggest that this combined therapy could be useful for the treatment of high-risk prostate cancer.

  2. Adaptive Echo Noise Elimination for Speech Enhancement of Tamil letter ‘Zha’

    A. Srinivasan

    2009-12-01

    Full Text Available Acoustic echo depends on time delay between initial and reflected sound wave, strength of reflected sound. In the speech processing of letter ‘zha’ [11], echo of the recorded voice gives the spurious results. Such complexity can be avoided by suitable pyramidalmethod like adaptive filtering technique. Adaptive filtering tries to adjust these parameters with the aim of meeting some well-defined target, which depends upon the state of the system and surroundings. In speech recognition, the acoustic echo gives the faulty results.Objective of this paper is to analyze the performance of various adaptive filtering algorithms for acoustic echo cancellation in recorded speech enhancement of the letter ‘Zha’ in Tamil language. These algorithms are simulated in MATLAB and compared with theperformance of those algorithms based on parameters such us computational complexity, convergence rate and amount of echo attenuation.

  3. Dual adaptive statistical approach for quantitative noise reduction in photon-counting medical imaging: application to nuclear medicine images

    Noise reduction in photon-counting images remains challenging, especially at low count levels. We have developed an original procedure which associates two complementary filters using a Wiener-derived approach. This approach combines two statistically adaptive filters into a dual-weighted (DW) filter. The first one, a statistically weighted adaptive (SWA) filter, replaces the central pixel of a sliding window with a statistically weighted sum of its neighbors. The second one, a statistical and heuristic noise extraction (extended) (SHINE-Ext) filter, performs a discrete cosine transformation (DCT) using sliding blocks. Each block is reconstructed using its significant components which are selected using tests derived from multiple linear regression (MLR). The two filters are weighted according to Wiener theory. This approach has been validated using a numerical phantom and a real planar Jaszczak phantom. It has also been illustrated using planar bone scintigraphy and myocardial single-photon emission computed tomography (SPECT) data. Performances of filters have been tested using mean normalized absolute error (MNAE) between the filtered images and the reference noiseless or high-count images.Results show that the proposed filters quantitatively decrease the MNAE in the images and then increase the signal-to-noise Ratio (SNR). This allows one to work with lower count images. The SHINE-Ext filter is well suited to high-size images and low-variance areas. DW filtering is efficient for low-size images and in high-variance areas. The relative proportion of eliminated noise generally decreases when count level increases. In practice, SHINE filtering alone is recommended when pixel spacing is less than one-quarter of the effective resolution of the system and/or the size of the objects of interest. It can also be used when the practical interest of high frequencies is low. In any case, DW filtering will be preferable.The proposed filters have been applied to nuclear

  4. 多通道自适应噪声抵消系统%An adaptive multi-channel anti-noise system

    于新颖

    2015-01-01

    对多通道自适应噪声抵消系统的噪声抑制能力进行了MATLAB仿真分析,结果表明,多通道系统的抑噪能力高于单通道系统,信噪比增益提高了1.36 dB左右。%We study the noise checking ability of an adaptive multi‐channel anti‐noise system with MATLAB simulation .The results show that the noise checking ability of the adaptive multi‐channel system is better than that of single‐channel ,and the signal‐to‐noise ratio increases by about 1 .36 dB .

  5. Adaptive Signal Detection and Parameter Estimation in Unknown Colored Gaussian Noise

    Tang, Bo; Kay, Steven

    2016-01-01

    This paper considers the general signal detection and parameter estimation problem in the presence of colored Gaussian noise disturbance. By modeling the disturbance with an autoregressive process, we present three signal detectors with different unknown parameters under the general framework of binary hypothesis testing. The closed form of parameter estimates and the asymptotic distributions of these three tests are also given. Given two examples of frequency modulated signal detection problem and time series moving object detection problem, the simulation results demonstrate the effectiveness of three presented detectors.

  6. HIFU Therapy Compared with Other Thermal Ablation Methods in a Perfused Organ Model

    Jenne, Jürgen W.; Risse, Frank; Häcker, Axel; Peters, Kristina; Siegler, Peter; Divkovic, Gabriela Wilzbach; Huber, Peter E.

    2007-05-01

    Therapy with high intensity focused ultrasound (HIFU) has been shown to be both safe and clinically practical in a growing number of patient studies for a variety of different target organs. Especially in cancer therapy there are comparable ablation methods like radio frequency (RFA) or laser (LITT) ablation, which are clinically more accepted. In an ongoing study we compare HIFU with RF- and laser ablation under MRI guidance in a perfused organ model. All evaluated techniques were appropriate to induce defined and localized ablation necrosis in the renal cortex. Our HIFU system and the laser system were completely MRI compatible. The tested RF- system showed local needle artefacts and disturbed the MR images during operation. The ablation rate of HIFU using a spot scanning technique was clearly lower compared to the other ablation techniques. However, advanced HIFU scanning methods might overcome this limitation. In addition HIFU is the only complete non-invasive ablation technique.

  7. Weighted Robust Adaptive Filtering in Krein Space and Its Application in Active Noise Control

    Jayawardhana, Bayu; Yuan, Shuqing; Xie, Lihua

    2002-01-01

    Robust adaptive filtering ensures the minimization of the transfer function from the disturbance to the estimation error and thus, guarantees the robustness against the worst-case disturbance in the system. However, a more general approach will be given in this paper hy employing frequency weighting, which offers flexibility in determining robustness sensitivity in certain frequency of interest. Using the projection in Krein space, we developed a weighted recursive H∞ filtering that computes ...

  8. High intensity focused ultrasound (HIFU) as the alternative method of treatment of oncourological diseases

    Blyumberg B.I.; Fomkin R.N.; Popkov V.M.

    2012-01-01

    Increasing interest devoted to technology of high intensity focused ultrasound (high-intensity focused ultrasound, HIFU), basically, is explained by a wide spectrum of potential fields of application at minimum invasiveness of the given method. In oncourology HIFU is applied in prostate and kidney cancer. In case of tumors of renal parenchyma the given technique is being clinically tested, while HIFU is currently used in the practice of European oncourologists in treatment of prostate cancer....

  9. Immune System Modulation with LOFU And HIFU Treatment of Prostate Cancer

    Guha, C.; Huagang, Z.; Chen, W.; Carlosn, R.; Sanghvi, N. T.

    2011-09-01

    High intensity focused ultrasound (HIFU) results in instantaneous coagulative tissue necrosis. In contrast, "low" energy focused ultrasound (LOFU) induces membrane perturbation while maintaining cell viability. This report explores the tumor immunomodulatory roles of LOFU and HIFU combination treatment. We hypothesized that administration of repeated cycles of LOFU, followed by HIFU would release tumor-derived peptide-heat shock protein complexes in the blood and induce systemic tumor-specific immune response that would enhance tumor control of both local and systemic disease.

  10. High-Intensity Focused Ultrasound (HIFU) in Uterine Fibroid Treatment: Review Study

    MAHMOUD, MUSTAFA Z.; Alkhorayef, Mohammed; Alzimami, Khalid S.; Aljuhani, Manal Saud; Sulieman, Abdelmoneim

    2014-01-01

    Summary Background High-intensity focused ultrasound (HIFU) is a highly precise medical procedure used locally to heat and destroy diseased tissue through ablation. This study intended to review HIFU in uterine fibroid therapy, to evaluate the role of HIFU in the therapy of leiomyomas as well as to review the actual clinical activities in this field including efficacy and safety measures beside the published clinical literature. Material/Methods An inclusive literature review was carried out ...

  11. Seismic random noise elimination according to the adaptive fractal conservation law

    Meng, Fanlei; Li, Yue; Zeng, Qian

    2016-05-01

    The fractal conservation law (FCL) is based on the Cauchy problem of the partial differential equation (PDE), which is modified by an anti-diffusive term of lower order. The analysis indicates that it can eliminate the high frequencies and preserve or amplify the low/medium frequencies. The performance of FCL depends on the threshold selected for the PDE. This threshold corresponds to the cut-off frequency of FCL in the frequency domain. Generally, the threshold is fixed. Thus, the FCL cannot track the signal beyond the cut-off frequency, and it removes the higher-frequency components of the signal. To solve this problem, an adaptive FCL filtering method is presented. The main purpose of this method is to select the optimal FCL threshold in each sample index such that it can adaptively track the rapid changes in the signal. In the adaptive FCL, we select FCL estimations with different thresholds and construct a convex hull of these estimations of each sample index. Consequently, we introduce a quadratic functional with respect to FCL estimation to ensure that we select the optimal estimation from the convex hull of each sample index. This leads to a box-constrained convex problem, which can be solved by the Viterbi algorithm.

  12. Linear adaptive noise-reduction filters for tomographic imaging: Optimizing for minimum mean square error

    Sun, W Y [Lawrence Berkeley Lab., CA (United States)

    1993-04-01

    This thesis solves the problem of finding the optimal linear noise-reduction filter for linear tomographic image reconstruction. The optimization is data dependent and results in minimizing the mean-square error of the reconstructed image. The error is defined as the difference between the result and the best possible reconstruction. Applications for the optimal filter include reconstructions of positron emission tomographic (PET), X-ray computed tomographic, single-photon emission tomographic, and nuclear magnetic resonance imaging. Using high resolution PET as an example, the optimal filter is derived and presented for the convolution backprojection, Moore-Penrose pseudoinverse, and the natural-pixel basis set reconstruction methods. Simulations and experimental results are presented for the convolution backprojection method.

  13. Combination of the transurethral resection and prostate HIFU ablation at treatment of the localized cancer

    Popkov V.M.

    2014-09-01

    26 patients were included into HIFU and 74 group in group of the combined treatment (TURP+HIFU. Selection criteria for HIFU ablation were the localized cancer of a prostate concerning which earlier it wasn't carried out treatments, and level of a PSA at the time of statement of the diagnosis 15 ng/ml. All patients corresponding to these by criteria, were considered as candidates for treatment and inclusion in the analysis. The nadir and stability of PSA, the histologic conclusion, IPSS, quality of life and complication were estimated at time of postoperative supervision. Results: Statistically significant influence of a combination TURP+HIFU for the term of transurethral drainage of a bladder (a median of 40 days against 7 days, incontience frequency (15.4% against 6.9%, infections of urinary ways (47.9% against 11.4% and IPSS change during the postoperative period (on the average 8.91 against 3.37 is noted. During the short period of supervision it wasn't observed considerable changes in relation to efficiency: in HIFU group the frequency of repeated sessions made 25%, in TUR/HIFU group 4%. Conclusion: HIFU therapy is modern, minimum invasive method of a cancer therapy of a prostate. The combination of a transurethral resection and HIFU ablation significantly reduces the frequency of the complications connected with treatment. Maintaining the patient after combined TURP and HIFU ablation is comparable with maintaining the patient after usual TURP.

  14. The role of numerical simulation for the development of an advanced HIFU system

    Okita, Kohei; Narumi, Ryuta; Azuma, Takashi; Takagi, Shu; Matumoto, Yoichiro

    2014-10-01

    High-intensity focused ultrasound (HIFU) has been used clinically and is under clinical trials to treat various diseases. An advanced HIFU system employs ultrasound techniques for guidance during HIFU treatment instead of magnetic resonance imaging in current HIFU systems. A HIFU beam imaging for monitoring the HIFU beam and a localized motion imaging for treatment validation of tissue are introduced briefly as the real-time ultrasound monitoring techniques. Numerical simulations have a great impact on the development of real-time ultrasound monitoring as well as the improvement of the safety and efficacy of treatment in advanced HIFU systems. A HIFU simulator was developed to reproduce ultrasound propagation through the body in consideration of the elasticity of tissue, and was validated by comparison with in vitro experiments in which the ultrasound emitted from the phased-array transducer propagates through the acrylic plate acting as a bone phantom. As the result, the defocus and distortion of the ultrasound propagating through the acrylic plate in the simulation quantitatively agree with that in the experimental results. Therefore, the HIFU simulator accurately reproduces the ultrasound propagation through the medium whose shape and physical properties are well known. In addition, it is experimentally confirmed that simulation-assisted focus control of the phased-array transducer enables efficient assignment of the focus to the target. Simulation-assisted focus control can contribute to design of transducers and treatment planning.

  15. High-Intensity Focused Ultrasound (HIFU) in Uterine Fibroid Treatment: Review Study

    High-intensity focused ultrasound (HIFU) is a highly precise medical procedure used locally to heat and destroy diseased tissue through ablation. This study intended to review HIFU in uterine fibroid therapy, to evaluate the role of HIFU in the therapy of leiomyomas as well as to review the actual clinical activities in this field including efficacy and safety measures beside the published clinical literature. An inclusive literature review was carried out in order to review the scientific foundation, and how it resulted in the development of extracorporeal distinct devices. Studies addressing HIFU in leiomyomas were identified from a search of the Internet scientific databases. The analysis of literature was limited to journal articles written in English and published between 2000 and 2013. In current gynecologic oncology, HIFU is used clinically in the treatment of leiomyomas. Clinical research on HIFU therapy for leiomyomas began in the 1990s, and the majority of patients with leiomyomas were treated predominantly with HIFUNIT 9000 and prototype single focus ultrasound devices. HIFU is a non-invasive and highly effective standard treatment with a large indication range for all sizes of leiomyomas, associated with high efficacy, low operative morbidity and no systemic side effects. Uterine fibroid treatment using HIFU was effective and safe in treating symptomatic uterine fibroids. Few studies are available in the literature regarding uterine artery embolization (UAE). HIFU provides an excellent option to treat uterine fibroids

  16. Design, Fabrication, and Testing of SMA Enabled Adaptive Chevrons for Jet Noise Reduction

    Turner, Travis L.; Buehrle, Ralph D.; Cano, Roberto J.; Fleming, Gary A.

    2004-01-01

    This study presents the status and results from an effort to design, fabricate, and test an adaptive jet engine chevron concept based upon embedding shape memory alloy (SMA) actuators in a composite laminate, termed a SMA hybrid composite (SMAHC). The approach for fabricating the adaptive SMAHC chevrons involves embedding prestrained Nitinol actuators on one side of the mid-plane of the composite laminate such that thermal excitation generates a thermal moment and deflects the structure. A glass-epoxy pre-preg/Nitinol ribbon material system and a vacuum hot press consolidation approach are employed. A versatile test system for control and measurement of the chevron deflection performance is described. Projection moire interferometry (PMI) is used for global deformation measurement and infrared (IR) thermography is used for 2-D temperature measurement and feedback control. A recently commercialized constitutive model for SMA and SMAHC materials is used in the finite element code ABAQUS to perform nonlinear static analysis of the chevron prototypes. Excellent agreement is achieved between the predicted and measured chevron deflection performance, thereby validating the design tool. Although the performance results presented in this paper fall short of the requirement, the concept is proven and an approach for achieving the performance objectives is evident.

  17. New parameters in adaptive testing of ferromagnetic materials utilizing magnetic Barkhausen noise

    Pal'a, Jozef; Ušák, Elemír

    2016-03-01

    A new method of magnetic Barkhausen noise (MBN) measurement and optimization of the measured data processing with respect to non-destructive evaluation of ferromagnetic materials was tested. Using this method we tried to found, if it is possible to enhance sensitivity and stability of measurement results by replacing the traditional MBN parameter (root mean square) with some new parameter. In the tested method, a complex set of the MBN from minor hysteresis loops is measured. Afterward, the MBN data are collected into suitably designed matrices and optimal parameters of MBN with respect to maximum sensitivity to the evaluated variable are searched. The method was verified on plastically deformed steel samples. It was shown that the proposed measuring method and measured data processing bring an improvement of the sensitivity to the evaluated variable when comparing with measuring traditional MBN parameter. Moreover, we found a parameter of MBN, which is highly resistant to the changes of applied field amplitude and at the same time it is noticeably more sensitive to the evaluated variable.

  18. Noise Estimation and Adaptive Encoding for Asymmetric Quantum Error Correcting Codes

    Florjanczyk, Jan; Brun, Todd; Center for Quantum Information Science; Technology Team

    We present a technique that improves the performance of asymmetric quantum error correcting codes in the presence of biased qubit noise channels. Our study is motivated by considering what useful information can be learned from the statistics of syndrome measurements in stabilizer quantum error correcting codes (QECC). We consider the case of a qubit dephasing channel where the dephasing axis is unknown and time-varying. We are able to estimate the dephasing angle from the statistics of the standard syndrome measurements used in stabilizer QECC's. We use this estimate to rotate the computational basis of the code in such a way that the most likely type of error is covered by the highest distance of the asymmetric code. In particular, we use the [ [ 15 , 1 , 3 ] ] shortened Reed-Muller code which can correct one phase-flip error but up to three bit-flip errors. In our simulations, we tune the computational basis to match the estimated dephasing axis which in turn leads to a decrease in the probability of a phase-flip error. With a sufficiently accurate estimate of the dephasing axis, our memory's effective error is dominated by the much lower probability of four bit-flips. Aro MURI Grant No. W911NF-11-1-0268.

  19. CT and Ultrasound Guided Stereotactic High Intensity Focused Ultrasound (HIFU)

    To demonstrate the feasibility of CT and B-mode Ultrasound (US) targeted HIFU, a prototype coaxial focused ultrasound transducer was registered and integrated to a CT scanner. CT and diagnostic ultrasound were used for HIFU targeting and monitoring, with the goals of both thermal ablation and non-thermal enhanced drug delivery. A 1 megahertz coaxial ultrasound transducer was custom fabricated and attached to a passive position-sensing arm and an active six degree-of-freedom robotic arm via a CT stereotactic frame. The outer therapeutic transducer with a 10 cm fixed focal zone was coaxially mounted to an inner diagnostic US transducer (2-4 megahertz, Philips Medical Systems). This coaxial US transducer was connected to a modified commercial focused ultrasound generator (Focus Surgery, Indianapolis, IN) with a maximum total acoustic power of 100 watts. This pre-clinical paradigm was tested for ability to heat tissue in phantoms with monitoring and navigation from CT and live US. The feasibility of navigation via image fusion of CT with other modalities such as PET and MRI was demonstrated. Heated water phantoms were tested for correlation between CT numbers and temperature (for ablation monitoring). The prototype transducer and integrated CT/US imaging system enabled simultaneous multimodality imaging and therapy. Pre-clinical phantom models validated the treatment paradigm and demonstrated integrated multimodality guidance and treatment monitoring. Temperature changes during phantom cooling corresponded to CT number changes. Contrast enhanced or non-enhanced CT numbers may potentially be used to monitor thermal ablation with HIFU. Integrated CT, diagnostic US, and therapeutic focused ultrasound bridges a gap between diagnosis and therapy. Preliminary results show that the multimodality system may represent a relatively inexpensive, accessible, and simple method of both targeting and monitoring HIFU effects. Small animal pre-clinical models may be translated to large

  20. Findings of multidetector row computed tomography of HCCs treated by HIFU ablation

    Purpose: We evaluated the efficacy of high-intensity focused ultrasound (HIFU) ablation for hepatocellular carcinoma (HCC), and a long-term study by follow-up multidetector-row computed tomography (CT) was conducted to evaluate the changes occurring in the treatment area following the HIFU ablation. Materials and methods: HIFU ablation was carried out in 14 patients with small HCCs (≤3 lesions, ≤3 cm in diameter). The HIFU system (Chongqing Haifu Tech) was used under ultrasound guidance. The evaluations were performed by follow-up CT at 1 week, 1, 3, 6 and 12 months after the HIFU ablation. Results: HIFU ablation was carried out successfully in 11 of the 14 patients. At 1 week after the HIFU, a peripheral rim enhancement was found in all cases (100%). This finding was persistent in 6 of the 11 cases (54.5%) at 1 month, and in 1 of the 11 (9%) cases at 3 months after HIFU ablation. In all cases, the rim enhancement disappeared by 6 or 12 months after the HIFU ablation. At the 12 months follow-up, a decrease in the diameter of the ablated lesions was found. The enhancement around the treated area was found to be persistent at the 12 months follow-up in the one case of recurrence of the treated site in which the safety margin was not sufficiently wide. During the follow-up period, there were 2 cases with residual of HCC tumors. We performed radiofrequency ablation (RFA) for these residual tumors after the HIFU ablation. Conclusion: To ascertain the cause of the peripheral enhancement on follow-up CT images after the HIFU ablation, in particular, to determine whether it might be caused by residual tumor or recurrence at the treated site, careful follow-up is important, especially in cases where the safety margin of the ablated area was not sufficiently wide.

  1. [Framework design of MRI guided phased HIFU system and software development].

    Ma, Ruifeng; Shen, Guofeng; Qiao, Shan; Wei, Bo; Chen, Sheng; Chen, Yazhu

    2013-03-01

    This paper introduced a new structure of MRI guided P-HIFU therapy system and software implementation based on the current P-HIFU system and interface provided by MRI vendor. The tests showed that the system's software can achieve the appropriate form of treatment need. PMID:23777061

  2. High intensity focused ultrasound (HIFU as the alternative method of treatment of oncourological diseases

    Blyumberg B.I.

    2012-12-01

    Full Text Available Increasing interest devoted to technology of high intensity focused ultrasound (high-intensity focused ultrasound, HIFU, basically, is explained by a wide spectrum of potential fields of application at minimum invasiveness of the given method. In oncourology HIFU is applied in prostate and kidney cancer. In case of tumors of renal parenchyma the given technique is being clinically tested, while HIFU is currently used in the practice of European oncourologists in treatment of prostate cancer. The majority of the references describing the results of HIFU application in prostate cancer is based on data of a number of clinical observations. It has been proved that HIFU is a possible method of treatment of highly — and moderate-differentiated tumors, and local relapses after remote radial therapy.

  3. Investigation of HIFU-induced anti-tumor immunity in a murine tumor model

    Lyerly H Kim

    2007-07-01

    Full Text Available Abstract Background High intensity focused ultrasound (HIFU is an emerging non-invasive treatment modality for localized treatment of cancers. While current clinical strategies employ HIFU exclusively for thermal ablation of the target sites, biological responses associated with both thermal and mechanical damage from focused ultrasound have not been thoroughly investigated. In particular, endogenous danger signals from HIFU-damaged tumor cells may trigger the activation of dendritic cells. This response may play a critical role in a HIFU-elicited anti-tumor immune response which can be harnessed for more effective treatment. Methods Mice bearing MC-38 colon adenocarcinoma tumors were treated with thermal and mechanical HIFU exposure settings in order to independently observe HIFU-induced effects on the host's immunological response. In vivo dendritic cell activity was assessed along with the host's response to challenge tumor growth. Results Thermal and mechanical HIFU were found to increase CD11c+ cells 3.1-fold and 4-fold, respectively, as compared to 1.5-fold observed for DC injection alone. In addition, thermal and mechanical HIFU increased CFSE+ DC accumulation in draining lymph nodes 5-fold and 10-fold, respectively. Moreover, focused ultrasound treatments not only caused a reduction in the growth of primary tumors, with tumor volume decreasing by 85% for thermal HIFU and 43% for mechanical HIFU, but they also provided protection against subcutaneous tumor re-challenge. Further immunological assays confirmed an enhanced CTL activity and increased tumor-specific IFN-γ-secreting cells in the mice treated by focused ultrasound, with cytotoxicity induced by mechanical HIFU reaching as high as 27% at a 10:1 effector:target ratio. Conclusion These studies present initial encouraging results confirming that focused ultrasound treatment can elicit a systemic anti-tumor immune response, and they suggest that this immunity is closely related to

  4. A 3 to 5 GHz low-phase-noise fractional-N frequency synthesizer with adaptive frequency calibration for GSM/PCS/DCS/WCDMA transceivers

    A low-phase-noise Σ—Δ fractional-N frequency synthesizer for GSM/PCS/DCS/WCDMA transceivers is presented. The voltage controlled oscillator is designed with a modified digital controlled capacitor array to extend the tuning range and minimize phase noise. A high-resolution adaptive frequency calibration technique is introduced to automatically choose frequency bands and increase phase-noise immunity. A prototype is implemented in 0.13 μm CMOS technology. The experimental results show that the designed 1.2 V wideband frequency synthesizer is locked from 3.05 to 5.17 GHz within 30 μs, which covers all five required frequency bands. The measured in-band phase noise are −89, −95.5 and −101 dBc/Hz for 3.8 GHz, 2 GHz and 948 MHz carriers, respectively, and accordingly the out-of-band phase noise are −121, −123 and −132 dBc/Hz at 1 MHz offset, which meet the phase-noise-mask requirements of the above-mentioned standards. (semiconductor integrated circuits)

  5. Evaluation of temperature rise in a tissue mimicking material during HIFU exposure

    Maruvada, S; Liu, Y; Herman, B A; Harris, G R, E-mail: subha.maruvada@fda.hhs.gov [Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Ave., Bldg., Silver Spring, MD 20993 (United States)

    2011-02-01

    In pre-clinical testing it is essential to characterize clinical high intensity focused ultrasound (HIFU) devices using tissue-mimicking materials (TMMs) with well known characteristics, including temperature rise and cavitation properties. The purpose of this study was to monitor cavitation behavior and correlate its effect with temperature rise in a HIFU TMM containing an embedded thermocouple. A 75-{mu}m fine wire thermocouple was embedded in a hydrogel-based TMM previously developed for HIFU. HIFU at 1.1 and 3.3 MHz was focused at the thermocouple junction. Focal pressures from 1-11 MPa were applied and the temperature profiles were recorded. Three hydrophones were used to monitor cavitation activity during sonication. A hydrophone confocal with the HIFU transducer and a cylindrical hydrophone lateral to the HIFU beam were used as passive cavitation detectors for spectral analysis of signals, and a needle hydrophone placed beyond the HIFU focus was used to record changes in the pressure amplitude due to blockage by bubbles at or near the focus. B-mode imaging scans were employed to visualize bubble presence during sonication. In a separate measurement, schlieren imaging was used to monitor the change in field distribution behind the TMM. All hydrophone methods correlated well with cavitation in the TMM.

  6. Evaluation of temperature rise in a tissue mimicking material during HIFU exposure

    In pre-clinical testing it is essential to characterize clinical high intensity focused ultrasound (HIFU) devices using tissue-mimicking materials (TMMs) with well known characteristics, including temperature rise and cavitation properties. The purpose of this study was to monitor cavitation behavior and correlate its effect with temperature rise in a HIFU TMM containing an embedded thermocouple. A 75-μm fine wire thermocouple was embedded in a hydrogel-based TMM previously developed for HIFU. HIFU at 1.1 and 3.3 MHz was focused at the thermocouple junction. Focal pressures from 1-11 MPa were applied and the temperature profiles were recorded. Three hydrophones were used to monitor cavitation activity during sonication. A hydrophone confocal with the HIFU transducer and a cylindrical hydrophone lateral to the HIFU beam were used as passive cavitation detectors for spectral analysis of signals, and a needle hydrophone placed beyond the HIFU focus was used to record changes in the pressure amplitude due to blockage by bubbles at or near the focus. B-mode imaging scans were employed to visualize bubble presence during sonication. In a separate measurement, schlieren imaging was used to monitor the change in field distribution behind the TMM. All hydrophone methods correlated well with cavitation in the TMM.

  7. Segmentation of uterine fibroid ultrasound images using a dynamic statistical shape model in HIFU therapy.

    Ni, Bo; He, Fazhi; Yuan, ZhiYong

    2015-12-01

    Segmenting the lesion areas from ultrasound (US) images is an important step in the intra-operative planning of high-intensity focused ultrasound (HIFU). However, accurate segmentation remains a challenge due to intensity inhomogeneity, blurry boundaries in HIFU US images and the deformation of uterine fibroids caused by patient's breathing or external force. This paper presents a novel dynamic statistical shape model (SSM)-based segmentation method to accurately and efficiently segment the target region in HIFU US images of uterine fibroids. For accurately learning the prior shape information of lesion boundary fluctuations in the training set, the dynamic properties of stochastic differential equation and Fokker-Planck equation are incorporated into SSM (referred to as SF-SSM). Then, a new observation model of lesion areas (named to RPFM) in HIFU US images is developed to describe the features of the lesion areas and provide a likelihood probability to the prior shape given by SF-SSM. SF-SSM and RPFM are integrated into active contour model to improve the accuracy and robustness of segmentation in HIFU US images. We compare the proposed method with four well-known US segmentation methods to demonstrate its superiority. The experimental results in clinical HIFU US images validate the high accuracy and robustness of our approach, even when the quality of the images is unsatisfactory, indicating its potential for practical application in HIFU therapy. PMID:26459767

  8. HIFU Ultrasound Power Measurements at INRiM

    Durando, G; Guglielmone, C; Musacchio, C, E-mail: g.durando@inrim.it [INRIM strada delle cacce 91, 10135 Torino (Italy)

    2011-02-01

    In this work the new system for the ultrasound power measurement of High Intensity Focused Ultrasound transducers realized at INRIM ultrasounds laboratory is presented. The system is based on a submersible load cell that takes the place of the balance. This solution presents essentially two advantages. The first one, of mechanical nature, is relevant to the fact that the target is directly connected to the force transducer, eliminating unwanted target motion at high power. The second, of electric nature, concerns the possibility to reduce the insonation time (the ON period of the electric driving signal to the HIFU transducer) under of 2 s, and is allowed for by the faster response of the force transducer (700 Hz bandwidth). The main components of uncertainty and the overall budget of the measurement system are presented together with the results of measures of conductance, G, carried on a HIFU transducer, at the work frequencies 2.0 MHz and 6.38 MHz, for values of power ranging from 10 W to 100 W. The results of the ultrasonic conductance, G, obtained with the new system are compared with values obtained using the traditional measuring system for low powers (P {<=} 20W).

  9. Approaches to overcome current limitations of HIFU treatment

    Umemura, Shin-Ichiro; Kawabata, Ken-Ichi; Sasaki, Kazuaki; Azuma, Takashi; Ishida, Kazunari; Kubota, Jun; Ichihara, Mitsuyoshi; Okai, Takashi

    2001-05-01

    Noninvasive therapy with HIFU has been successfully applied to transrectal treatment of prostate cancer as well as benign prostate hyperplasia. However, there are two major technical reasons why its clinical application to other organs is currently limited: (1) low throughput of treatment and (2) lack of penetration to deep tissues. To multiply the throughput, a split-focus technique, in which the focal spot is enlarged primarily in the lateral direction, was developed. An electronically variable focus array transducer was also developed to enhance the throughput. An approach to treat a large volume of uterus myoma by coagulating its feeding arteries has been studied. The tissue volume to be coagulated can be thereby reduced by orders of magnitude. The penetration and throughput can potentially be improved at the same time by delivering a microbubble agent to the target tissue. It was theoretically predicted that a microbubble agent could multiply the ultrasonic tissue absorption. The effectiveness of this approach was confirmed in animal experiments using Optison. Real-time monitoring of tissue coagulation during HIFU exposure also can enhance the throughput through preventing excess deposition of ultrasonic energy. Monitoring coagulation by imaging local displacement in tissue with ultrasound will be discussed as well.

  10. Development of HIFU Therapy System for Lower Extremity Varicose Veins

    High-intensity focused ultrasound (HIFU) treatment utilizing microbubbles was investigated in the present study. It is known that microbubbles have the potential to enhance the heating effects of an ultrasound field. In this study, the heat accompanying microbubble oscillation was used to occlude varicose veins. Alteration of veins was observed after ultrasound irradiation. Veins were resected by stripping. In this study, two vein conditions were adopted during HIFU irradiation; non-compressed and compressed. Compressing the vein was expected to improve occlusion by rubbing the altered intima under compressed conditions. The frequency of the ultrasound was 1.7 MHz, the intensity at the focus was 2800 W/cm2, and the irradiation time was 20 s. In this study, the contrast agent Levovist registered was chosen as a microbubble source, and the void fraction (ratio of total gas volume to liquid) in the vein was fixed at 10-5. Under non-compressed conditions, changes were observed only at the adventitia of the vein anterior wall. In contrast, under compressed conditions, changes were observed from the intima to the adventitia of both the anterior and posterior walls, and they were partly stuck together. In addition, more experiments with hematoxylin-eosin staining suggested that the changes in the vein were more substantial under the latter conditions. From these results, it was confirmed that the vein was occluded more easily with vein compression.

  11. HIFU Ultrasound Power Measurements at INRiM

    In this work the new system for the ultrasound power measurement of High Intensity Focused Ultrasound transducers realized at INRIM ultrasounds laboratory is presented. The system is based on a submersible load cell that takes the place of the balance. This solution presents essentially two advantages. The first one, of mechanical nature, is relevant to the fact that the target is directly connected to the force transducer, eliminating unwanted target motion at high power. The second, of electric nature, concerns the possibility to reduce the insonation time (the ON period of the electric driving signal to the HIFU transducer) under of 2 s, and is allowed for by the faster response of the force transducer (700 Hz bandwidth). The main components of uncertainty and the overall budget of the measurement system are presented together with the results of measures of conductance, G, carried on a HIFU transducer, at the work frequencies 2.0 MHz and 6.38 MHz, for values of power ranging from 10 W to 100 W. The results of the ultrasonic conductance, G, obtained with the new system are compared with values obtained using the traditional measuring system for low powers (P ≤ 20W).

  12. HIFU Ultrasound Power Measurements at INRiM

    Durando, G.; Guglielmone, C.; Musacchio, C.

    2011-02-01

    In this work the new system for the ultrasound power measurement of High Intensity Focused Ultrasound transducers realized at INRIM ultrasounds laboratory is presented. The system is based on a submersible load cell that takes the place of the balance. This solution presents essentially two advantages. The first one, of mechanical nature, is relevant to the fact that the target is directly connected to the force transducer, eliminating unwanted target motion at high power. The second, of electric nature, concerns the possibility to reduce the insonation time (the ON period of the electric driving signal to the HIFU transducer) under of 2 s, and is allowed for by the faster response of the force transducer (700 Hz bandwidth). The main components of uncertainty and the overall budget of the measurement system are presented together with the results of measures of conductance, G, carried on a HIFU transducer, at the work frequencies 2.0 MHz and 6.38 MHz, for values of power ranging from 10 W to 100 W. The results of the ultrasonic conductance, G, obtained with the new system are compared with values obtained using the traditional measuring system for low powers (P <= 20W).

  13. Simulation of Transrib HIFU Propagation and the Strategy of Phased-array Activation

    Zhou, Yufeng; Wang, Mingjun

    Liver ablation is challenging in high-intensity focused ultrasound (HIFU) because of the presence of ribs and great inhomogeneity in multi-layer tissue. In this study, angular spectrum approach (ASA) has been used in the wave propagation from phased-array HIFU transducer, and diffraction, attenuation and the nonlinearity are accounted for by means of second order operator splitting method. Bioheat equation is used to simulate the subsequent temperature elevation and lesion formation with the formation of shifted focus and multiple foci. In summary, our approach could simulate the performance of phased-array HIFU in the clinics and then develop an appropriate treatment plan.

  14. High intensity focused ultrasound (HIFU) focal spot localization using harmonic motion imaging (HMI)

    Han, Yang; Hou, Gary Yi; Wang, Shutao; Konofagou, Elisa

    2015-08-01

    Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of high-intensity focused ultrasound (HIFU) treatment. However, accurate localization and characterization of the effective region of treatment (focal spot) remain important obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a HIFU monitoring technique that utilizes radiation-force-induced localized oscillatory displacement. HMIFU has been shown to correctly identify the formation and extent of HIFU thermal ablation lesions. However a significant problem remains in identifying the location of the HIFU focus, which is necessary for treatment planning. In this study, the induced displacement was employed to localize the HIFU focal spot inside the tissue prior to treatment. Feasibility was shown with two separate systems. The 1D HMIFU system consisted of a HIFU transducer emitting an amplitude-modulated HIFU beam for mechanical excitation and a confocal single-element, pulse-echo transducer for simultaneous RF acquisition. The 2D HIFU system consists of a HIFU phased array, and a co-axial imaging phased array for simultaneous imaging. Initial feasibility was first performed on tissue-mimicking gelatin phantoms and the focal zone was defined as the region corresponding to the  -3dB full width at half maximum of the HMI displacement. Using the same parameters, in vitro experiments were performed in canine liver specimens to compare the defined focal zone with the lesion. In vitro measurements showed good agreement between the HMI predicted focal zone and the induced HIFU lesion location. HMIFU was experimentally shown to be capable of predicting and tracking the focal region in both phantoms and in vitro tissues. The accuracy of focal spot localization was evaluated by comparing with the lesion location in post-ablative tissues, with a R2 = 0.821 at p  HIFU focal spot without inducing thermal changes

  15. High intensity focused ultrasound (HIFU) focal spot localization using harmonic motion imaging (HMI).

    Han, Yang; Hou, Gary Yi; Wang, Shutao; Konofagou, Elisa

    2015-08-01

    Several ultrasound-based imaging modalities have been proposed for image guidance and monitoring of high-intensity focused ultrasound (HIFU) treatment. However, accurate localization and characterization of the effective region of treatment (focal spot) remain important obstacles in the clinical implementation of HIFU ablation. Harmonic motion imaging for focused ultrasound (HMIFU) is a HIFU monitoring technique that utilizes radiation-force-induced localized oscillatory displacement. HMIFU has been shown to correctly identify the formation and extent of HIFU thermal ablation lesions. However a significant problem remains in identifying the location of the HIFU focus, which is necessary for treatment planning. In this study, the induced displacement was employed to localize the HIFU focal spot inside the tissue prior to treatment. Feasibility was shown with two separate systems. The 1D HMIFU system consisted of a HIFU transducer emitting an amplitude-modulated HIFU beam for mechanical excitation and a confocal single-element, pulse-echo transducer for simultaneous RF acquisition. The 2D HIFU system consists of a HIFU phased array, and a co-axial imaging phased array for simultaneous imaging. Initial feasibility was first performed on tissue-mimicking gelatin phantoms and the focal zone was defined as the region corresponding to the -3dB full width at half maximum of the HMI displacement. Using the same parameters, in vitro experiments were performed in canine liver specimens to compare the defined focal zone with the lesion. In vitro measurements showed good agreement between the HMI predicted focal zone and the induced HIFU lesion location. HMIFU was experimentally shown to be capable of predicting and tracking the focal region in both phantoms and in vitro tissues. The accuracy of focal spot localization was evaluated by comparing with the lesion location in post-ablative tissues, with a R(2) = 0.821 at p < 0.002 in the 2D HMI system. We demonstrated the

  16. Progress in Development of HIFU CMUTs for use under MR-guidance

    High intensity focused ultrasound (HIFU) guided by magnetic resonance imaging (MRI) is a noninvasive treatment that potentially reduces patient morbidity, lowers costs, and increases treatment accessibility. Traditionally, piezoelectric transducers are used for HIFU, but capacitive micromachined ultrasonic transducers (CMUTs) have many advantages, including fabrication flexibility, low loss, and efficient transmission. We designed, fabricated, and tested HIFU CMUTs for use under MRI guidance and have demonstrated continuous wave (CW) focusing. In this paper, we demonstrate that CMUTs can be designed for therapeutic ultrasound. First, we demonstrate successful unfocused heating of a HIFU phantom to 18.6 deg. C, which was successfully monitored under MR guidance. Second, we demonstrated a focused CMUT array whose beam profile matched with simulation. In the future, we will expand the array and system for upper abdominal cancer therapy.

  17. Novel Non-invasive Treatment With High-intensity Focused Ultrasound (HIFU).

    Marinova, M; Rauch, M; Schild, H H; Strunk, H M

    2016-02-01

    Ultrasound is not only used for diagnostic purposes but it also can be applied therapeutically so far that nowadays high-intensity focused ultrasound (HIFU) even represents a novel non-invasive treatment modality for various solid tumors. HIFU works by causing selectively deep tissue destruction of target lesions within the body without harming adjacent and overlying structures. In this article, we present an overview on both the mode of action and requirements for a HIFU treatment as well as on the safety and the current status of indications and possible applications with regard to benign and malignant gynecological diseases. Based on numerous studies and original articles, HIFU proved to be an effective and low-risk treatment option particularly for uterine fibroids and adenomyosis, but it also seems to be effective for breast fibroadenomas or even for breast cancer in special cases and other rare entities. PMID:26251996

  18. Class-DE Ultrasound Transducer Driver for HIFU Therapy.

    Christoffersen, Carlos; Wong, Wai; Pichardo, Samuel; Togtema, Greg; Curiel, Laura

    2016-04-01

    This paper presents a practical implementation of an integrated MRI-compatible CMOS amplifier capable of directly driving a piezoelectric ultrasound transducer suitable for high-intensity focused ultrasound (HIFU) therapy. The amplifier operates in Class DE mode without the need for an output matching network. The integrated amplifier has been implemented with the AMS AG H35 CMOS process. A class DE amplifier design methodology for driving unmatched piezoelectric loads is presented along with simulation and experimental results. The proposed design achieves approximately 90% efficiency with over 800 mW of output power at 1010 kHz. The total die area including pads is 2 mm(2) . Compatibility with MRI was validated with B1 imaging of a phantom and the amplifier circuit. PMID:25955850

  19. HIFU Transducer Characterization Using a Robust Needle Hydrophone

    Howard, Samuel M.; Zanelli, Claudio I.

    2007-05-01

    A robust needle hydrophone has been developed for HIFU transducer characterization and reported on earlier. After a brief review of the hydrophone design and performance, we demonstrate its use to characterize a 1.5 MHz, 10 cm diameter, F-number 1.5 spherically focused source driven to exceed an intensity of 1400 W/cm2at its focus. Quantitative characterization of this source at high powers is assisted by deconvolving the hydrophone's calibrated frequency response in order to accurately reflect the contribution of harmonics generated by nonlinear propagation in the water testing environment. Results are compared to measurements with a membrane hydrophone at 0.3% duty cycle and to theoretical calculations, using measurements of the field at the source's radiating surface as input to a numerical solution of the KZK equation.

  20. Whole Body Bone Scan Findings after High Intensity Focused Ultrasound (HIFU) Treatment

    Seo, Ye Young; O, Joo Hyun; Sohn, Hyung Sun; Choi, Eun Kyoung; Yoo, Ik Dong; Oh, Jin Kyoung; Han, Eun Ji; Jung, Seung Eun; Kim, Sung Hoon [The Catholic Univ. of Korea, Seoul (Korea, Republic of)

    2011-12-15

    This study aims to examine the findings of {sup 99mT}c diphosphonate bone scans in cancer patients with a history of HIFU treatment. Bone scan images of patients with a history of HIFU treatment for primary of metastatic cancer from January 2006 to July 2010 were retrospectively reviewed. Cases of primary bone tumor or HIFU treatment reaching only the superficial soft tissue layer were excluded. Bone scan images of 62 patients (26 female, 36 male; mean age 57{+-}9 years) were studied. HIFU treatment was performed in the liver (n=40), pancreas (n=40), pancreas (n=16), and breast (n=6). Mean interval time between HIFU treatment and bone scan was 106{+-}105 days (range: 1-572 days). Of 62 scans, 43 showed diffusely decreased uptake of bone within the path of HIFU treatment: antero axillary and/or posterior arcs of right 5th to 11th ribs in 34 cases after treatment of hepatic lesions; anterior arcs of 2nd to 5th ribs in 5 cases after treatment for breast tumors; and posterior arcs of left 9th to 11th ribs or thoraco lumbar vertebrae in 4 cases after treatment for pancreas tumor. Of 20 patients who had bone scans more than twice, five showed recovered uptake of the radiotracer in the involved ribs in the follow up bone scan. Of 62 bone scans in patients with a history of HIFU treatment for primary of metastatic cancer, 69% presented diffusely decreased uptake in the bone in the path of HIFU treatment.

  1. Whole Body Bone Scan Findings after High Intensity Focused Ultrasound (HIFU) Treatment

    This study aims to examine the findings of 99mTc diphosphonate bone scans in cancer patients with a history of HIFU treatment. Bone scan images of patients with a history of HIFU treatment for primary of metastatic cancer from January 2006 to July 2010 were retrospectively reviewed. Cases of primary bone tumor or HIFU treatment reaching only the superficial soft tissue layer were excluded. Bone scan images of 62 patients (26 female, 36 male; mean age 57±9 years) were studied. HIFU treatment was performed in the liver (n=40), pancreas (n=40), pancreas (n=16), and breast (n=6). Mean interval time between HIFU treatment and bone scan was 106±105 days (range: 1-572 days). Of 62 scans, 43 showed diffusely decreased uptake of bone within the path of HIFU treatment: antero axillary and/or posterior arcs of right 5th to 11th ribs in 34 cases after treatment of hepatic lesions; anterior arcs of 2nd to 5th ribs in 5 cases after treatment for breast tumors; and posterior arcs of left 9th to 11th ribs or thoraco lumbar vertebrae in 4 cases after treatment for pancreas tumor. Of 20 patients who had bone scans more than twice, five showed recovered uptake of the radiotracer in the involved ribs in the follow up bone scan. Of 62 bone scans in patients with a history of HIFU treatment for primary of metastatic cancer, 69% presented diffusely decreased uptake in the bone in the path of HIFU treatment.

  2. First Experience Of Application Of High-Intensity Focused Ultrasonic Ablation (Hifu) In Prostate Cancer Treatment

    A.V. Stativko; B.I. Blumberg; A.N. Ponukalin; R.N. Fomkin; P.V. Glybochko

    2009-01-01

    The scientific article points out that 40 sessions of HIFU prostate ablation have been performed for estimation of clinical efficiency. Average frequency of influences presents 628±164 impulses; average volume of tissues subjected to influence during one procedure is 33,8±16,3 smi (132 %) of prostate volume; average operation time constitutes 150 minutes (from 90 to 200 minutes). During the operation no complications have been occurred. In the first days after the session of HIFU there was a ...

  3. Characterization of HIFU transducers designed for sonochemistry application: Acoustic streaming.

    Hallez, L; Touyeras, F; Hihn, J-Y; Bailly, Y

    2016-03-01

    Cavitation distribution in a High Intensity Focused Ultrasound sonoreactors (HIFU) has been extensively described in the recent literature, including quantification by an optical method (Sonochemiluminescence SCL). The present paper provides complementary measurements through the study of acoustic streaming generated by the same kind of HIFU transducers. To this end, results of mass transfer measurements (electrodiffusional method) were compared to optical method ones (Particle Image Velocimetry). This last one was used in various configurations: with or without an electrode in the acoustic field in order to have the same perturbation of the wave propagation. Results show that the maximum velocity is not located at the focal but shifted near the transducer, and that this shift is greater for high powers. The two cavitation modes (stationary and moving bubbles) are greatly affect the hydrodynamic behavior of our sonoreactors: acoustic streaming and the fluid generated by bubble motion. The results obtained by electrochemical measurements show the same low hydrodynamic activity in the transducer vicinity, the same shift of the active focal toward the transducer, and the same absence of activity in the post-focal axial zone. The comparison with theoretical Eckart's velocities (acoustic streaming in non-cavitating media) confirms a very high activity at the "sonochemical focal", accounted for by wave distortion, which induced greater absorption coefficients. Moreover, the equivalent liquid velocities are one order of magnitude larger than the ones measured by PIV, confirming the enhancement of mass transfer by bubbles oscillation and collapse close to the surface, rather than from a pure streaming effect. PMID:26585023

  4. High-intensity focused ultrasound treatment (HIFU) for the advanced pancreatic cancer

    Song, In Ho; Jung, Seung Eun; Hahn, Seong Tai; Jang, Jin Hee; Cho, Se Hyun; Han, Joon Yeol; Kim, Jin Il; Lee, Ji Young; Sung, Choon Ho [St. Mary' Hospital, the Catholic University of Korea, Seoul (Korea, Republic of)

    2007-06-15

    We wanted to evaluate the levels of effect and safety of high-intensity focused ultrasound ablation (HIFU) for treating patients with advanced pancreatic cancer. Nineteen sessions of HIFU, with the patients under general anesthesia, were performed in 18 patients with advanced pancreatic cancer. The change of the gray-scale of the target lesion was analyzed during HIFU, and MRI was performed before and after HIFU. We assessed the extent of coagulative necorsis, the change of pain and the complications after HIFU. The change of tumor size and the survival of patients were also evaluated. The average size of tumor was 4 cm in diameter. Eighty nine percent of the target tumors showed increased echogenicity. On MRI, necrosis of the entire target tumor occurred in 79% of the patients. After treatment, effective pain relief was noted in 89% of the patients. There were no major complications. No size increase of the treated tumor was noted during 24 weeks of follow-up for 10 patients. Six patients among 12 patients who were available for follow-up are still alive and they are receiving chemotherapy. Six patients expired due to other disease or progression of metastasis. HIFU is a safe method without any major complications, and it is effective for inducing tumor necrosis and achieving pain control for patients with advanced pancreatic cancer.

  5. Segmentation of tumor ultrasound image in HIFU therapy based on texture and boundary encoding

    It is crucial in high intensity focused ultrasound (HIFU) therapy to detect the tumor precisely with less manual intervention for enhancing the therapy efficiency. Ultrasound image segmentation becomes a difficult task due to signal attenuation, speckle effect and shadows. This paper presents an unsupervised approach based on texture and boundary encoding customized for ultrasound image segmentation in HIFU therapy. The approach oversegments the ultrasound image into some small regions, which are merged by using the principle of minimum description length (MDL) afterwards. Small regions belonging to the same tumor are clustered as they preserve similar texture features. The mergence is completed by obtaining the shortest coding length from encoding textures and boundaries of these regions in the clustering process. The tumor region is finally selected from merged regions by a proposed algorithm without manual interaction. The performance of the method is tested on 50 uterine fibroid ultrasound images from HIFU guiding transducers. The segmentations are compared with manual delineations to verify its feasibility. The quantitative evaluation with HIFU images shows that the mean true positive of the approach is 93.53%, the mean false positive is 4.06%, the mean similarity is 89.92%, the mean norm Hausdorff distance is 3.62% and the mean norm maximum average distance is 0.57%. The experiments validate that the proposed method can achieve favorable segmentation without manual initialization and effectively handle the poor quality of the ultrasound guidance image in HIFU therapy, which indicates that the approach is applicable in HIFU therapy. (paper)

  6. High-intensity focused ultrasound treatment (HIFU) for the advanced pancreatic cancer

    We wanted to evaluate the levels of effect and safety of high-intensity focused ultrasound ablation (HIFU) for treating patients with advanced pancreatic cancer. Nineteen sessions of HIFU, with the patients under general anesthesia, were performed in 18 patients with advanced pancreatic cancer. The change of the gray-scale of the target lesion was analyzed during HIFU, and MRI was performed before and after HIFU. We assessed the extent of coagulative necorsis, the change of pain and the complications after HIFU. The change of tumor size and the survival of patients were also evaluated. The average size of tumor was 4 cm in diameter. Eighty nine percent of the target tumors showed increased echogenicity. On MRI, necrosis of the entire target tumor occurred in 79% of the patients. After treatment, effective pain relief was noted in 89% of the patients. There were no major complications. No size increase of the treated tumor was noted during 24 weeks of follow-up for 10 patients. Six patients among 12 patients who were available for follow-up are still alive and they are receiving chemotherapy. Six patients expired due to other disease or progression of metastasis. HIFU is a safe method without any major complications, and it is effective for inducing tumor necrosis and achieving pain control for patients with advanced pancreatic cancer

  7. Segmentation of tumor ultrasound image in HIFU therapy based on texture and boundary encoding

    Zhang, Dong; Xu, Menglong; Quan, Long; Yang, Yan; Qin, Qianqing; Zhu, Wenbin

    2015-02-01

    It is crucial in high intensity focused ultrasound (HIFU) therapy to detect the tumor precisely with less manual intervention for enhancing the therapy efficiency. Ultrasound image segmentation becomes a difficult task due to signal attenuation, speckle effect and shadows. This paper presents an unsupervised approach based on texture and boundary encoding customized for ultrasound image segmentation in HIFU therapy. The approach oversegments the ultrasound image into some small regions, which are merged by using the principle of minimum description length (MDL) afterwards. Small regions belonging to the same tumor are clustered as they preserve similar texture features. The mergence is completed by obtaining the shortest coding length from encoding textures and boundaries of these regions in the clustering process. The tumor region is finally selected from merged regions by a proposed algorithm without manual interaction. The performance of the method is tested on 50 uterine fibroid ultrasound images from HIFU guiding transducers. The segmentations are compared with manual delineations to verify its feasibility. The quantitative evaluation with HIFU images shows that the mean true positive of the approach is 93.53%, the mean false positive is 4.06%, the mean similarity is 89.92%, the mean norm Hausdorff distance is 3.62% and the mean norm maximum average distance is 0.57%. The experiments validate that the proposed method can achieve favorable segmentation without manual initialization and effectively handle the poor quality of the ultrasound guidance image in HIFU therapy, which indicates that the approach is applicable in HIFU therapy.

  8. Flat HIFU transducer with a sawtooth-shaped ultrasound radiation face

    Son, Keon-Ho; Cho, Young-Ki; Kim, Dae-Seung; Kim, Myung-Deok; Kang, Kook-Jin

    2013-10-01

    High-intensity focused ultrasound (HIFU) transducers are spherically-curved in order to obtain a high intensity gain of the converged ultrasound energy at the geometrical focus. Ultrasound imaging devices monitor the procedure of HIFU treatment in ultrasound-guided HIFU systems where the image probe is positioned at the apex of the HIFU transducer, which has a spherical surface. However, the remote image probe's location yields a poor image quality compared to that obtained using conventional ultrasound imaging where the image probe is in direct contact with the surface. A phased array HIFU transducer with a new structure is suggested to overcome this limitation. The centers of the array elements are distributed over the flat surface of the transducer. However, the elements are tilted to form a geometrical focus, like a transducer with a spherically-curved surface, to obtain a high focal gain. The cross-section of the ultrasound radiation face of the transducer resembles the teeth of a saw. The acoustic field emitted from this transducer was simulated in order to design and produce the transducer. The simulation was compared with the measured sound field to verify that the transducer was correctly manufactured and designed; subsequently, the acoustic power was measured, and ultrasound images were obtained through the installation of an image probe on the transducer, which confirmed the application of this transducer to HIFU treatment.

  9. Design and evaluation of a transesophageal HIFU probe for ultrasound-guided cardiac ablation: simulation of a HIFU mini-maze procedure and preliminary ex vivo trials.

    Constanciel, Elodie; N'Djin, W Apoutou; Bessière, Francis; Chavrier, Françoise; Grinberg, Daniel; Vignot, Alexandre; Chevalier, Philippe; Chapelon, Jean Yves; Lafon, Cyril

    2013-09-01

    Atrial fibrillation (AF) is the most frequent cardiac arrhythmia. Left atrial catheter ablation is currently performed to treat this disease. Several energy sources are used, such as radio-frequency or cryotherapy. The main target of this procedure is to isolate the pulmonary veins. However, significant complications caused by the invasive procedure are described, such as stroke, tamponade, and atrioesophageal fistula, and a second intervention is often needed to avoid atrial fibrillation recurrence. For these reasons, a minimally-invasive device allowing performance of more complex treatments is still needed. High-intensity focused ultrasound (HIFU) can cause deep tissue lesions without damaging intervening tissues. Left atrial ultrasound-guided transesophageal HIFU ablation could have the potential to become a new ablation technique. The goal of this study was to design and test a minimally-invasive ultrasound-guided transesophageal HIFU probe under realistic treatment conditions. First, numerical simulations were conducted to determine the probe geometry, and to validate the feasibility of performing an AF treatment using a HIFU mini-maze (HIFUMM) procedure. Then, a prototype was manufactured and characterized. The 18-mm-diameter probe head housing contained a 3-MHz spherical truncated HIFU transducer divided into 8 rings, with a 5-MHz commercial transesophageal echocardiography (TEE) transducer integrated in the center. Finally, ex vivo experiments were performed to test the impact of the esophagus layer between the probe and the tissue to treat, and also the influence of the lungs and the vascularization on lesion formation. First results show that this prototype successfully created ex vivo transmural myocardial lesions under ultrasound guidance, while preserving intervening tissues (such as the esophagus). Ultrasound-guided transesophageal HIFU can be a good candidate for treatment of AF in the future. PMID:24658718

  10. Adapt

    Bargatze, L. F.

    2015-12-01

    Active Data Archive Product Tracking (ADAPT) is a collection of software routines that permits one to generate XML metadata files to describe and register data products in support of the NASA Heliophysics Virtual Observatory VxO effort. ADAPT is also a philosophy. The ADAPT concept is to use any and all available metadata associated with scientific data to produce XML metadata descriptions in a consistent, uniform, and organized fashion to provide blanket access to the full complement of data stored on a targeted data server. In this poster, we present an application of ADAPT to describe all of the data products that are stored by using the Common Data File (CDF) format served out by the CDAWEB and SPDF data servers hosted at the NASA Goddard Space Flight Center. These data servers are the primary repositories for NASA Heliophysics data. For this purpose, the ADAPT routines have been used to generate data resource descriptions by using an XML schema named Space Physics Archive, Search, and Extract (SPASE). SPASE is the designated standard for documenting Heliophysics data products, as adopted by the Heliophysics Data and Model Consortium. The set of SPASE XML resource descriptions produced by ADAPT includes high-level descriptions of numerical data products, display data products, or catalogs and also includes low-level "Granule" descriptions. A SPASE Granule is effectively a universal access metadata resource; a Granule associates an individual data file (e.g. a CDF file) with a "parent" high-level data resource description, assigns a resource identifier to the file, and lists the corresponding assess URL(s). The CDAWEB and SPDF file systems were queried to provide the input required by the ADAPT software to create an initial set of SPASE metadata resource descriptions. Then, the CDAWEB and SPDF data repositories were queried subsequently on a nightly basis and the CDF file lists were checked for any changes such as the occurrence of new, modified, or deleted

  11. Report on research of calculus fragmentation by HIFU-induced cavitation in Tsinghua University: 2. Thermal effects

    Thermal effects in the research of breaking kidney stones using HIFU-induced cavitation were studied. Damages to the phantom could be observed after an acting period of HIFU. It was shown that temperature rise is much greater in phantom than in water. Greatest changes occur near the focal region of HIFU transducer. Distinct temperature changes can be observed with input of continuous signals, while modest changes appear with input of pulsed signals. The fact that pulsed signals generate less damage, indicate the favourable acting patterns of HIFU. More tests are being done at the moment.

  12. Nanoparticle-enhanced synergistic HIFU ablation and transarterial chemoembolization for efficient cancer therapy

    You, Yufeng; Wang, Zhigang; Ran, Haitao; Zheng, Yuanyi; Wang, Dong; Xu, Jinshun; Wang, Zhibiao; Chen, Yu; Li, Pan

    2016-02-01

    High-intensity focused ultrasound (HIFU) is being generally explored as a non-invasive therapeutic modality to treat solid tumors. However, the clinical use of HIFU for large and deep tumor-ablation applications such as hepatocellular carcinoma (HCC) is currently entangled with long treatment duration and high operating energy. This critical issue can be potentially resolved by the introduction of HIFU synergistic agents (SAs). Traditional SAs such as microbubbles and microparticles face the problem of large size, short cycle time, damage to mononuclear phagocytic system and unsatisfactory targeting efficiency. In this work, we have developed a facile and versatile nanoparticle-based HIFU synergistic cancer surgery enhanced by transarterial chemoembolization for high-efficiency HCC treatment based on elaborately designed Fe3O4-PFH/PLGA nanocapsules. Multifunctional Fe3O4-PFH/PLGA nanocapsules were administrated into tumor tissues via transarterial injection combined with Lipiodol to achieve high tumor accumulation because transarterial chemoembolization by Lipiodol could block the blood vessels. The high synergistic HIFU ablation effect was successfully achieved against HCC tumors based on the phase-transformation performance of the perfluorohexane (PFH) inner core in the composite nanocapsules, as systematically demonstrated in VX2 liver tumor xenograft in rabbits. Multifunctional Fe3O4-PFH/PLGA nanocapsules were also demonstrated as efficient contrast agents for ultrasound, magnetic resonance and photoacoustic tri-modality imagings, potentially applicable for imaging-guided HIFU synergistic surgery. Therefore, the elaborate integration of traditional transarterial chemoembolization with recently developed nanoparticle-enhanced HIFU cancer surgery could efficiently enhance the HCC cancer treatment outcome, initiating a new and efficient therapeutic protocol/modality for clinic cancer treatment.

  13. Robotic high-intensity focused ultrasound (rHIFU) for the prostate cancer treatment

    Solovov, Vyacheslav; Shaplygin, Leonid; Vozdvizhenskiy, Mikhail

    2012-11-01

    Introduction & Objectives: rHIFU shows a successful treatment for localized prostate cancer (PC). Here we explored the effectiveness of the rHIFU treatment for the prostate cancer, hormone-resistant prostate cancer (HRPC) and failure after external beam radiotherapy (EBRT) and radical prostatectomy (RPE). Materials & Methods: 748 patients were treated in our center between Sep 2007 - February 2012: 137 - hormone-resistance (median time before hormone-resistance 25 months), 286 - received neoadjuvant hormone therapy 6 months, 293 - no treatment before HIFU, 32 - after the EBRT failure. 667 patients underwent TURP+rHIFU, 81 only rHIFU (volume prostate prostate volume - 39 (5,5-108) cc. Results: Median PSA level 12 months after rHIFU treatment were 0,04 (0-2,24) ng/ml - low risk group, for high risk group - 0,5 (0-48,4) ng/ml, with failure after EBRT and RPE- 0,5 (0-3,2) ng/ml; 36 months after rHIFU treatment were 0,5 (0,02-3,6) ng/ml - low risk group, for high risk group - 3,2 (0-21,38) ng/ml, with failure after EBRT and RPE - 1,7 (0-9,8) ng/ml. Patients with low risk had 4,5% of progression, with high risk PC - 25%, with failure after EBRT and RPE - 19,6%. Kaplan-Meir analyses of the total group indicated that the risk of progression after 1 year follow-up was 10%, the risk of progression was 23% after 4 years of follow-up. Complications: incontinence I - 17,5%, incontinence II - 7,7%, stricture - 18,2%, fistula - 0,3 %. Conclusions: Our experience shows that rHIFU ablation is safe, minimally invasive, effective treatment with moderate side effects for the PC, hormone-resistant prostate cancer, rHIFU also may be used as a salvage therapy after EBRF. Further studies are required.

  14. Alternative Focal Spot Geometry for More Efficient HIFU Treatment Assessment

    Kaye, Elena; Chen, Jing; Medan, Yoav; Pauly, Kim Butts

    2010-03-01

    In this work a more time efficient approach for tissue assessment with MR-ARFI is proposed. During HIFU treatments gadolinium-free assessment of treated tissue is highly desirable. MR-ARFI allows measuring tissue displacement in the focal spot. Therefore raster-scanning the ultrasound focal spot through the tissue of interest can give information about tissue stiffness in the "probed" area. To enhance efficiency of such ultrasound "probing," we replaced a conventional point focus with a line focus that allows greater area coverage during MR-ARFI acquisitions. This approach was tested in a phantom and in ex vivo bovine muscle. The results of the study showed that the line focus produces a fairly uniform line shape focal spot in both temperature and displacement maps. Using one line focus position, the displacement maps obtained in the muscle tissue well depicted the difference in displacement in the area where lesion was created. This shows great potential for line focus geometry combined with MR-ARFI as an alternative treatment assessment technique.

  15. Interactions H.I.F.U. / polymer films

    Hallez, L.; Touyeras, F.; Hihn, J.-Y.; Bailly, Y.

    2010-01-01

    In order to obtain the modification of a defined volume of a polymer layer, preliminary tests of sonication (HIFU 0.75 and 3 MHz) were carried out to obtain an accurate characterization of the acoustic fields as well as convective flow velocities measured close to the surface by Particle Image Velocimetry and luminol mapping. Then, sonication of a delimited zone of an acrylic resin deposited upon a stainless steel thin substrate highlighted a strong dependence of the polymerization or reticulation degree, with different exposure times and different power thresholds for the same final modification. The point was to examine the ability of the thin polymer film to absorb ultrasonic energy or to act as a perfect reflector which induces asymmetric cavitation and therefore violent collapses to take place close to the surface. In the first case, the wave absorption by the film is converted into heat and then acts for the polymer alteration under the high convective flow velocities. For the highest acoustic intensities and for the hardest films, cavitation occurs and the produced microbubbles oscillated and grow close to the surface. Then, the shocks resulting of the bubble collapse eroded mechanically the film.

  16. Salvage HIFU for biopsy confirmed local prostate cancer recurrence after radical prostatectomy and radiation therapy: Case report and literature review.

    Rittberg, Rebekah; Kroczak, Tadeusz; Fleshner, Neil; Drachenberg, Darrel

    2015-01-01

    High-intensity focused ultrasound (HIFU) is a treatment option for low- and intermediate-risk prostate cancer and more recently has been used as salvage therapy after failed radiation therapy. We present a case of local recurrence with biochemical failure after radical prostatectomy and salvage external beam radiation therapy with salvage HIFU without biochemical recurrence at 20 months. PMID:26425239

  17. Salvage HIFU for biopsy confirmed local prostate cancer recurrence after radical prostatectomy and radiation therapy: Case report and literature review

    Rittberg, Rebekah; Kroczak, Tadeusz; Fleshner, Neil; Drachenberg, Darrel

    2015-01-01

    High-intensity focused ultrasound (HIFU) is a treatment option for low- and intermediate-risk prostate cancer and more recently has been used as salvage therapy after failed radiation therapy. We present a case of local recurrence with biochemical failure after radical prostatectomy and salvage external beam radiation therapy with salvage HIFU without biochemical recurrence at 20 months.

  18. Feasibility of laser-integrated high intensity focused ultrasound (HIFU) treatment for bladder tumors: in vitro study (Conference Presentation)

    Nguyen, Van Phuc; Park, Suhyun; Oh, Junghwan; Kang, Hyun Wook

    2016-02-01

    Previous studies have shown that photothemal therapy combined with high intensity focused ultrasound (HIFU) can provide a promising method to achieve rapid thermal coagulation during surgical procedures. The current study investigated the feasibility of the laser-integrated high intensity focused ultrasound (HIFU) application to treat bladder tumors by enhancing thermal effects and therapeutic depth in vitro. To generate thermal coagulation, a single element HIFU transducer with a central frequency of 2.0 MHz was used to transmit acoustic energy to 15 fresh porcine bladders injected with an artificial tumor (100 µl gelatin and hemoglobin solution) in vitro. Simultaneously, an 80-W 532-nm laser system was also implemented to induce thermal necrosis in the targeted tissue. The intensity of 570 W/cm2 at the focus of HIFU and laser energy of 0.9 W were applied to all the samples for 40 s. The temperature rise increased up to about 1.6 or 3 folds (i.e., ΔT=32±3.8 K for laser-integrated HIFU, ΔT=20±6.5 K for HIFU only, and ΔT=11±5.6 K for laser only). The estimated lesion depth also increased by 1.3 and 2 folds during the dual-thermal treatment, in comparison with the treatment by either HIFU or laser. The results indicated that the laser-integrated HIFU treatment can be an efficient hyperthermic method for tumor coagulation.

  19. The Reduced Cochlear Output and the Failure to Adapt the Central Auditory Response Causes Tinnitus in Noise Exposed Rats

    Rüttiger, Lukas; Singer, Wibke; Panford-Walsh, Rama; Matsumoto, Masahiro; Lee, Sze Chim; Zuccotti, Annalisa; Zimmermann, Ulrike; Jaumann, Mirko; Rohbock, Karin; Xiong, Hao; Knipper, Marlies

    2013-01-01

    Tinnitus is proposed to be caused by decreased central input from the cochlea, followed by increased spontaneous and evoked subcortical activity that is interpreted as compensation for increased responsiveness of central auditory circuits. We compared equally noise exposed rats separated into groups with and without tinnitus for differences in brain responsiveness relative to the degree of deafferentation in the periphery. We analyzed (1) the number of CtBP2/RIBEYE-positive particles in ribbo...

  20. Image noise-based dose adaptation in dynamic volume CT of the heart: dose and image quality optimisation in comparison with BMI-based dose adaptation

    To compare the image quality and radiation dose using image-noise (IN)-based determination of X-ray tube settings compared with a body mass index (BMI)-based protocol during CT coronary angiography (CTCA). Two hundred consecutive patients referred for CTCA to our institution were divided into two groups: BMI-based, 100 patients had CTCA with the X-ray tube current adjusted to the patient's BMI while maintaining a fixed tube potential of 120 kV; IN-based, 100 patients underwent imaging with the X-ray tube current and voltage adjusted to the IN measured within the mid-left ventricle on a pre-acquisition trans-axial image. Two independent cardiac radiologists performed blinded image quality assessment with quantification of the IN and signal-to-noise ratio (SNR) from the mid-LV and qualitative assessment using a three-point score. Radiation dose (CTDI and DLP) was recorded from the console. Results showed: IN (HU): BMI-based, 30.1 ± 9.9; IN-based, 33.1 ± 6.7; 32 % variation reduction (P = 0.001); SNR: BMI-based, 18.6 ± 7.1; IN-based, 15.4 ± 3.7; 48 % variation reduction (P < 0.0001). Visual scores: BMI-based, 2.3 ± 0.6; IN-based, 2.2 ± 0.5 (P = 0.54). Radiation dose: CTDI (mGy), BMI-based, 22.68 ± 8.9; IN-based, 17.16 ± 7.6; 24.3 % reduction (P < 0.001); DLP (mGy.cm), BMI-based, 309.3 ± 127.5; IN-based, 230.6 ± 105.5; 25.4 % reduction (P < 0.001). Image-noise-based stratification of X-ray tube parameters for CTCA results in 32 % improvement in image quality and 25 % reduction in radiation dose compared with a BMI-based protocol. (orig.)

  1. Clinical applications for magnetic resonance guided high intensity focused ultrasound (MRgHIFU): present and future

    It has been well known for decades that high intensity focused ultrasound (HIFU) generates heat in tissues resulting in coagulative necrosis. Implementation, however, has been slow, due to difficulties with finding an appropriate imaging modality that could not only guide treatment, but also provide real-time thermal feedback. These problems have been overcome with the newest magnetic resonance-guided high intensity focused ultrasound systems (MRgHIFU). With its superior spatial resolution enabling accurate image guidance coupled with its ability to provide real-time thermography during treatments, MRI is moving further into the realm of therapeutics for oncologic patient care. This article will discuss the implementation of an MR-guided HIFU system, current clinical indications and touch on future directions.

  2. The Efficacy of High-Intensity Focused Ultrasound (HIFU) in Advanced Pancreatic Cancer

    Bo Xie; Jiajun Ling; Weiming Zhang; Xueqin Huang; Jihua Zhen; Yanzhe Huang

    2008-01-01

    OBJECTIVE To observe the efficacy of high-intensity focused ultrasound (HIFU)in the treatment of late-stage pancreatic cancer.METHODS Sixteen patients with advanced pancreatic cancer received HIFU therapy.Evaluation of efficacy was made on the basis of changes in clinical symptoms and variations in the tumor echo and size.RESULTS Clinical symptoms such as pain were significantly alleviated,echo of the tumor was enhanced with B-US and the quality of life such as eating,sleeping and mental status was markedly improved;no serious complications were observed.CONCLUSION The use of HIFU in the treatment of advanced pancreatic cancer is feasible and safe.It is effective in killing the carcinoma cells and alleviaring pain.This technique may offer non-invasive therapy for the treatment of patients with late-stage pancreatic cancer.

  3. Contrast Agent Ultrasonography before and after HIFU Treatment of Parathyroid Glands

    Kovatcheva, Roussanka; Arnaud, Françoise; Lacoste, François

    2010-03-01

    OBJECTIVES: To observe changes in the parathyroid tissue treated by extracorporeal HIFU. MATERIAL AND METHODS: 5 patients were treated for primary hyperparathyroidism by thermally ablating enlarged parathyroid glands using an external HIFU applicator. The treated glands were visualized with B-Mode and contrast enhanced ultrasonography (CEUS) before, 1 week and 4 weeks post HIFU. Serum iPTH, calcium, and phosphorus levels were monitored before and after the treatment. RESULTS: The initial results showed a correlation between contrast agent uptake of treated parathyroid tissue, the reduction of volume of the gland and the decrease of iPTH levels. CONCLUSIONS These results show it is possible to use CEUS to monitor the thermal ablation of parathyroid glands.

  4. Noise suppression by noise

    Vilar, J. M. G.; Rubí Capaceti, José Miguel

    2001-01-01

    We have analyzed the interplay between an externally added noise and the intrinsic noise of systems that relax fast towards a stationary state, and found that increasing the intensity of the external noise can reduce the total noise of the system. We have established a general criterion for the appearance of this phenomenon and discussed two examples in detail.

  5. Sonoluminescence characterization of inertial cavitation inside a BSA phantom treated by pulsed HIFU.

    Yin, Hui; Chang, Nan; Xu, Shanshan; Wan, Mingxi

    2016-09-01

    The aim of this study was to investigate the inertial cavitation inside a phantom treated by pulsed HIFU (pHIFU). Basic bovine serum albumin (BSA) phantoms without any inherent ultrasound contrast agents (UCAs) or phase-shift nano-emulsions (PSNEs) were used. During the treatment, sonoluminescence (SL) recordings were performed to characterize the spatial distribution of inertial cavitation adjacent to the focal region. High-speed photographs and thermal coagulations, comparing with the SL results, were also recorded and presented. A series of pulse parameters (pulse duration (PD) was between 1 and 23 cycles and pulse repetition frequency (PRF) was between 0.5kHz and 100kHz) were performed to make a systematic investigation under certain acoustic power (APW). Continuous HIFU (cHIFU) investigation was also performed to serve as control group. It was found that, when APW was 19.5W, pHIFU with short PD was much easier to form SL adjacent to the focal region inside the phantom, while it was difficult for cHIFU to generate cavitation bubbles. With appropriate PD and PRF, the residual bubbles of the previous pulses could be stimulated by the incident pulses to oscillate in a higher level and even violently collapse, resulting to enhanced physical thermogenesis. The experimental results showed that the most violent inertial cavitation occurs when PD was set to 6 cycles (5μs) and PRF to 10kHz, while the highest level of thermal coagulation was observed when PD was set to 10 cycles. The cavitational and thermal characteristics were in good correspondence, exhibiting significant potentiality regarding to inject-free cavitation bubble enhanced thermal ablation under lower APW, compared to the conventional thermotherapy. PMID:27150756

  6. Noise reduction of dental drill noise

    Rotter, KRGR; Atherton, MA; Kaymak, E; Millar, BJ

    2008-01-01

    Dental drills produce a characteristic noise that is uncomfortable for patients and is also known to be harmful to dentists under prolonged exposure. It is therefore desirable to protect the patient and dentist whilst allowing two-way communication, which will require a headphone - type system. Re-establishing good communication between the dentist and patient will be achieved through a combination of three noise cancellation technologies, namely, Passive Noise Control (PNC), Adaptive Filteri...

  7. A Pulsatile Flow Phantom for Image-Guided HIFU Hemostasis of Blood Vessels

    A pulsatile flow phantom for studying ultrasound image-guided acoustic hemostasis in a controlled environment has been developed. An ex vivo porcine carotid artery was attached to the phantom and embedded in a visually and ultrasonically transparent gel. Heparinized porcine blood was pumped through the phantom. Power-Doppler and B-mode ultrasound were used to remotely target the HIFU focus to the site of a needle puncture. In nine trials, complete hemostasis was achieved after an average HIFU application of 55 +/- 34 seconds. The vessels remained patent after treatment. With this phantom, it will be possible to do controlled studies of ultrasound image-guided acoustic hemostasis

  8. Transrectal Array Configurations Optimized For Prostate HIFU Ablation

    The objectives of this study were to evaluate and compare steering and ablation rates from several types of transrectal arrays operated at different frequencies for whole prostate ablation. Three-dimensional acoustic and thermal modeling (Rayleigh-Sommerfield and Penne's BHTE) were performed. Treatment volumes up to 70cc and anterior-posterior distances up to 6 cm were considered. The maximum transducer dimensions were constrained to 5 cm (along rectum) and 2.5 cm (elevation), and the channel count was limited to 256. Planar array configurations for truncated-annular, 1/1.5D, and 2D random arrays were evaluated at 1, 2, and 4 MHz for capability to treat the entire prostate. The acoustic intensity at the surface was fixed at 10 W/cm2. The maximum temperature was restricted to 80 deg. C. The volumetric ablation rate was computed to compare the treatment times amongst different configurations. The 1.5D Planar array at 1 MHz ablated the whole prostate in the shortest amount of time while maintaining adequate steering. The higher frequency arrays required smaller elevation apertures for a fixed channel count to maintain a single focal spot at the desired location. Consequently, these arrays resulted in slower heating rates with increased near-field heating. The 1 MHz 1.5D array would also be advantageous compared to single-element transducers since only one mechanical degree of motion is required. This study demonstrates the selection of an optimal array geometry and frequency for transrectal HIFU, resulting in faster ablation rates and reduced treatment times.

  9. A Bayesian approach to the inference of parametric configuration of the signal-to-noise ratio in an adaptive refinement of the measurements

    Marquez, Maria Jose

    2012-01-01

    Calibration is nowadays one of the most important processes involved in the extraction of valuable data from measurements. The current availability of an optimum data cube measured from a heterogeneous set of instruments and surveys relies on a systematic and robust approach in the corresponding measurement analysis. In that sense, the inference of configurable instrument parameters can considerably increase the quality of the data obtained. This paper proposes a solution based on Bayesian inference for the estimation of the configurable parameters relevant to the signal to noise ratio. The information obtained by the resolution of this problem can be handled in a very useful way if it is considered as part of an adaptive loop for the overall measurement strategy, in such a way that the outcome of this parametric inference leads to an increase in the knowledge of a model comparison problem in the context of the measurement interpretation. The context of this problem is the multi-wavelength measurements coming...

  10. Suppression Measured from Chinchilla Auditory-Nerve-Fiber Responses Following Noise-Induced Hearing Loss: Adaptive-Tracking and Systems-Identification Approaches.

    Sayles, Mark; Walls, Michael K; Heinz, Michael G

    2016-01-01

    The compressive nonlinearity of cochlear signal transduction, reflecting outer-hair-cell function, manifests as suppressive spectral interactions; e.g., two-tone suppression. Moreover, for broadband sounds, there are multiple interactions between frequency components. These frequency-dependent nonlinearities are important for neural coding of complex sounds, such as speech. Acoustic-trauma-induced outer-hair-cell damage is associated with loss of nonlinearity, which auditory prostheses attempt to restore with, e.g., "multi-channel dynamic compression" algorithms.Neurophysiological data on suppression in hearing-impaired (HI) mammals are limited. We present data on firing-rate suppression measured in auditory-nerve-fiber responses in a chinchilla model of noise-induced hearing loss, and in normal-hearing (NH) controls at equal sensation level. Hearing-impaired (HI) animals had elevated single-fiber excitatory thresholds (by ~ 20-40 dB), broadened frequency tuning, and reduced-magnitude distortion-product otoacoustic emissions; consistent with mixed inner- and outer-hair-cell pathology. We characterized suppression using two approaches: adaptive tracking of two-tone-suppression threshold (62 NH, and 35 HI fibers), and Wiener-kernel analyses of responses to broadband noise (91 NH, and 148 HI fibers). Suppression-threshold tuning curves showed sensitive low-side suppression for NH and HI animals. High-side suppression thresholds were elevated in HI animals, to the same extent as excitatory thresholds. We factored second-order Wiener-kernels into excitatory and suppressive sub-kernels to quantify the relative strength of suppression. We found a small decrease in suppression in HI fibers, which correlated with broadened tuning. These data will help guide novel amplification strategies, particularly for complex listening situations (e.g., speech in noise), in which current hearing aids struggle to restore intelligibility. PMID:27080669

  11. 一种色噪声下的自适应Kalman跟踪滤波器%An Adaptive Kalman Tracking Filter with Colored Noises

    孙强; 惠晓滨; 黄鹤

    2011-01-01

    有色噪声干扰情况下非线性系统的状态估计是许多实际工程需要解决的问题.该文章针对传统Kalman滤波器噪声统计特性未知时,受色噪声的影响精度严重降低,甚至出现发散等现象,设计了一种基于神经模糊网络的自适应的Kalman滤波跟踪器.该滤波器通过利用神经模糊网络作为误差估计器,估计出Kalman滤波器的估计误差,从而对Kalman滤波跟踪器的预测结果进行修正,得到更优的预测值.计算机仿真结果表明,该算法可以克服传统算法的局限性,有效地防止滤波器发散,缩小实际的滤波误差,提高滤波精度,实现对跟踪结果的在线改进.%Estimation in nonlinear system with Colored Noises is problem in many projects. The traditional Kalman Filter is still deficient in tracking targets in the nonlinear systems with colored noises.An adaptive Kalman tracking algorithm based on neuro-fuzzy network is proposed in the paper. The estimation error is obtained online to modify the filtered result with neuro-fuzzy network as the estimator.The analysis of simulation results indicates preliminarily that our better tracking algorithm does restrain colored noise and improve that tracking accuracy. At same time it can reduce error of traditional algorithm and improve the tracking accuracy of the system online.

  12. The nuclide imaging of primary malignant bone tumor before and after HIFU treatment

    Objective: To investigate the difference of bone nuclide imaging on primary malignant bone tumor before and after high intensity focused ultrasound (HIFU) treatment. Methods: 99Tcm-methylene-diphosphonate (MDP) bone imaging was applied before and after HIFU treatment and 99Tcm(V)-dimercaptosuccinic acid (DMSA) imaging was used when it was needed. Results: 1) There were areas of abnormal high uptake of 99Tcm-MDP in bone foci, while the lower uptake or no-uptake areas of 99Tcm-MDP outside the foci were found simultaneously. 2) The high uptake of 99Tcm(V)-DMSA in 5 cases after the HIFU treatment in the foci indicated the relapse of the former bone tumor. Conclusions: The location and extent of the tumor, and effectiveness of HIFU treatment can be estimated sensitively with 99Tcm-MDP bone imaging. The high uptake of 99Tcm(V)-DMSA in the focus indicates the relapse of the primary malignant bone tumor or new bone lesion in a certain degree

  13. Characterization of HIFU transducers designed for sonochemistry application: Cavitation distribution and quantification

    Hallez, L.; Touyeraz, F.; Hihn, J. Y.; Klíma, Jiří; Guey, J.-L.; Spajer, M.; Bailly, Y.

    2010-01-01

    Roč. 50, č. 2 (2010), s. 310-317. ISSN 0041-624X Institutional research plan: CEZ:AV0Z40400503 Keywords : HIFU * acoustic cavitation * MBSCL threshold * sonoreactors Subject RIV: CG - Electrochemistry Impact factor: 1.599, year: 2010

  14. Identification of risk factors of prostate adenocarcinoma recurrence after HIFU therapy using immunohistochemical markers

    Popkov V.M.

    2014-12-01

    Full Text Available The purpose of this study was to identify risk factors for recurrence of prostate adenocarcinoma after HIFU therapy. Material and methods: Material for the study was obtained from patients diagnosed with adenocarcinoma before and after HIFU treatment. Morphological study was conducted using a standard staining, and immunohistochemical markers: PCNA, Amacr, E-cadherin, Bel2, Andr, Estr, VEGF, P53, PCNA. Results: After treatment in 89% of patients with initial prostate volume greater than 50 cc the signs of recurrence of adenocarcinoma were showed. At low risk for D'Amico after treatment the expression of proliferation markers, VEGF, Amacr significantly decreased. With a high degree of risk — increased expression of Bel2. After treatment the expression of the following markers: PCNA, Amacr, VEGF significantly increased in the group of patients with the presence of invasion. Conclusion: Patients with initial prostate volume less than 50 cc, low risk to D'Amico, the lack of perineural and perivascular invasion have a low risk of recurrence after HIFU therapy; patients at high risk for D'Amico, the presence of perineural and perivascular invasion initial and prostate volume greater than 50 cc, low-grade cribriform form of adenocarcinoma have a high risk of recurrence of adenocarcinoma. Recurrence of adenocarcinoma develops independently of the period after HIFU therapy.

  15. Significant skin burns may occur with the use of a water balloon in HIFU treatment

    Ritchie, Robert; Collin, Jamie; Wu, Feng; Coussios, Constantin; Leslie, Tom; Cranston, David

    2012-10-01

    HIFU is a minimally-invasive therapy suitable for treating selected intra-abdominal tumors. Treatment is safe although skin burns may occur due to pre-focal heating. HIFU treatment of a renal transplant tumor located in the left lower abdomen was undertaken in our centre. Treatment was performed prone, requiring displacement of the abdominal wall away from the treatment field using a water balloon, constructed of natural rubber latex and filled with degassed water. Intra-operatively, ultrasound imaging and physical examination of the skin directly over the focal region was normal. Immediately post-operative, a full-thickness skin burn was evident at the periphery of the balloon location, outside the expected HIFU path. Three possibilities may account for this complication. Firstly, the water balloon may have acted as a lens, focusing the HIFU to a neo-focus off axis. Secondly, air bubbles may have been entrapped between the balloon and the skin, causing heating at the interface. Finally, heating of the isolated water within the balloon may have been sufficient to cause burning. In this case, the placement of a water balloon caused a significant skin burn. Care should be taken in their use as burns, situated off axis, may occur even if the overlying skin appears normal.

  16. Initial Experience with the Extracorporeal HIFU Knife with 49 Patients: Japanese Experience

    Ganaha, F.; Okuno, T.; Lee, C. O.; Shimizu, T.; Osako, K.; Oka, S.; Lee, K. H.; Chen, W. Z.; Zhu, H.; Park, S. H.; Qi, Z.; Shi, D.; Song, H. S.

    2005-03-01

    Forty nine patients with 63 tumours were treated with the Chongqing Haifu knife, as an adjunct to intra-arterial chemoinfusion. Treatment targets included breast (20 lesions), liver (16), bone (8), lymph-node (6), soft tissue (4), lung and pleura (4), pancreas (2), kidney (2) and adrenal gland (1). Follow-up contrast MRI was performed at 3 weeks to assess the effects of HIFU ablation. All cases completed the planned treatment. Of 25 lesions treated with the intention of complete tumour ablation, complete necrosis was obtained in 19 lesions (76%) including 4 secondary success cases. Among 32 lesions having partial and palliative treatment, tumour size was decreased in 6 lesions (21%), and good pain control was obtained in 6 out of 7 patients (86%). Skin injury was the most common complication after HIFU (16%), and was mostly a superficial dermal burn that did not necessitate any treatment. However, there was one patient with deep skin injury at an operation scar which resulted in skin perforation. Other adverse events included soft tissue swelling, prolonged fever, anorexia, persistent pain, shortness of the breath, sacroiliac joint fracture and prolonged diarrhoea. In our limited experience, superficial lesions (e.g. breast cancer, bone, soft tissue, lymph-node and pleural metastasis) appear to be good candidates for HIFU treatment. There appears to be a role for the HIFU knife in pain control for patients with bone metastasis and pancreatic cancer.

  17. Effects of oxytocin on high intensity focused ultrasound (HIFU) ablation of adenomysis: A prospective study

    Zhang, Xin [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Zou, Min; Zhang, Cai [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); He, Jia [Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000 (China); Mao, Shihua [Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000 (China); Wu, Qingrong [Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099 (China); He, Min [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan 629000 (China); Wang, Jian [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); Department of Obstetrics and Gynecology, Three Gorges Central Hospital, Chongqing 404000 (China); Zhang, Ruitao [Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China); Department of Obstetrics and Gynecology, Fuling Central Hospital, Chongqing 408099 (China); Zhang, Lian, E-mail: lianwzhang@yahoo.com [State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, Chongqing Key laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016 (China); Department of Obstetrics and Gynecology, Chongqing Haifu Hospital, Chongqing 401121 (China)

    2014-09-15

    Objective: To investigate the effects of oxytocin on high-intensity focused ultrasound (HIFU) ablation for the treatment of adenomyosis. Materials and methods: Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment. During HIFU treatment, 80 units of oxytocin was added in 500 ml of 0.9% normal saline running at the rate of 2 ml/min (0.32 U/min) in the oxytocin group, while 0.9% normal saline was used in the control group. Both patients and HIFU operators were blinded to oxytocin or saline application. Treatment results, adverse effects were compared. Results: When using oxytocin, the non-perfused volume (NPV) ratio was 80.7 ± 11.6%, the energy-efficiency factor (EEF) was 8.1 ± 9.9 J/mm{sup 3}, and the sonication time required to ablate 1 cm{sup 3} was 30.0 ± 36.0 s/cm{sup 3}. When not using oxytocin, the non-perfused volume ratio was 70.8 ± 16.7%, the EEF was 15.8 ± 19.6 J/mm{sup 3}, and the sonication time required to ablate 1 cm{sup 3} was 58.2 ± 72.7 S/cm{sup 3}. Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1 cm{sup 3} between the two groups was observed. No oxytocin related adverse effects occurred. Conclusion: Oxytocin could significantly decrease the energy for ablating adenomyosis with HIFU, safely enhance the treatment efficiency.

  18. Effects of oxytocin on high intensity focused ultrasound (HIFU) ablation of adenomysis: A prospective study

    Objective: To investigate the effects of oxytocin on high-intensity focused ultrasound (HIFU) ablation for the treatment of adenomyosis. Materials and methods: Eighty-six patients with adenomyosis from three hospitals were randomly assigned to the oxytocin group or control group for HIFU treatment. During HIFU treatment, 80 units of oxytocin was added in 500 ml of 0.9% normal saline running at the rate of 2 ml/min (0.32 U/min) in the oxytocin group, while 0.9% normal saline was used in the control group. Both patients and HIFU operators were blinded to oxytocin or saline application. Treatment results, adverse effects were compared. Results: When using oxytocin, the non-perfused volume (NPV) ratio was 80.7 ± 11.6%, the energy-efficiency factor (EEF) was 8.1 ± 9.9 J/mm3, and the sonication time required to ablate 1 cm3 was 30.0 ± 36.0 s/cm3. When not using oxytocin, the non-perfused volume ratio was 70.8 ± 16.7%, the EEF was 15.8 ± 19.6 J/mm3, and the sonication time required to ablate 1 cm3 was 58.2 ± 72.7 S/cm3. Significant difference in the NPV ratio, EEF, and the sonication time required to ablate 1 cm3 between the two groups was observed. No oxytocin related adverse effects occurred. Conclusion: Oxytocin could significantly decrease the energy for ablating adenomyosis with HIFU, safely enhance the treatment efficiency

  19. 自适应滤波器消除语音信号中混合噪声%Elimination of Mixed-noise in Speech Singal by Adaptive Filter

    高榕; 张仕凯; 李靖; 余昭杰; 丁传鹏; 李强

    2012-01-01

    The acquisition and transmission of speech signal are often mixed with a variety of noise or interference, such as sinusoidal narrow-band interference and Gaussian white noise. A simple adaptive filter is hard to filter out them simultaneously. In order to suppress mixed-noise to get a real voice signal,a two-stage adaptive filter program was proposed based on least mean square (LMS) adaptive algorithm and adaptive noise cancellation principle. By adding delay elements to a traditional adaptive noise cancellation, the first stage could eliminate the sinusoidal narrow-band interference, and the second stage was used to eliminate the Gaussian white noise. The two-stage adaptive filter was simulated by using Simulink block library. The simulation results show that the proposed filter can effectively filter out mixed-noise including sinusoidal narrow-band interference and Gaussian white noise,and improve the quality of speech signal.%语音信号在实际采集和传输的过程中,往往掺杂着多种噪声干扰,比较常见的是正弦窄带干扰和高斯白噪声,而一个简单的自适应滤波器往往很难同时滤除多种噪声.为了抑制混合噪声而得到真实的语音信号,在最小均方误差(LMS)自适应算法和自适应噪声抵消原理的基础上,提出了一种两级自适应滤波器方案,第1级在传统噪声抵消系统中加入延迟单元消除正弦窄带干扰,第Ⅱ级用LMS自适应噪声抵消器消除高斯白噪声,同时,利用Simulink模块库对所设计的两级自适应滤波器进行了建模仿真.仿真结果表明:该方案滤波器可以有效地滤除包含正弦窄带干扰和高斯白噪声的混合噪声,达到提高语音质量的目的.

  20. High Intensity Focused Ultrasound (HIFU) as a Salvage Treatment for Recurrent Prostate Cancer after Brachytherapy — a Feasibility Study

    Chapman, Alexander T.; Rivens, Ian H.; Thompson, Alan C.; ter Haar, Gail R.

    2007-05-01

    HIFU may be an effective salvage treatment for patients who develop local recurrence after permanent low-dose brachytherapy. It has been suggested that the presence of seeds in the prostate may obstruct the HIFU beam or alter the heating characteristics of the prostate tissue. Acoustic field measurements were made using a membrane hydrophone and lesioning experiments were carried out in ex vivo bovine liver. These revealed a significant effect of the seeds on the HIFU focal region as well as a reduction in lesion length when seeds were placed in a pre-focal position. Further work is needed to evaluate the full effects of implanted brachytherapy seeds on the clinical delivery of HIFU.

  1. Health-related quality of life after salvage high-intensity focused ultrasound (HIFU) treatment for locally radiorecurrent prostate cancer

    The objective of this study was to evaluate health-related quality of life (HRQOL) after salvage high-intensity focused ultrasound (HIFU) for locally radiorecurrent prostate cancer (PCa). Since June 2006 we have treated 61 patients consecutively by salvage HIFU. All patients were offered the University of California, Los Angeles Prostate Cancer Index (UCLA-PCI) questionnaire at baseline and at follow-up. Scores ranged from 0 (worst) to 100 (best). Clinically significant changes were defined as a minimum difference of 10 points between the baseline score and the score at follow-up. Fifty-seven patients (93%) had evaluable data at baseline, compared with 46 (75%) after treatment. The mean time lapse between HIFU treatment and questionnaire response was 17.5 months (range 6-29 months). The mean score for urinary function decreased from 79.7±12.1 prior to HIFU to 67.4±17.8 after HIFU (P<0.001). The mean score for sexual function decreased from 32.1±24.1 prior to HIFU to 17.2±17.0 after HIFU (P<0.001). There were no significant effects on bowel function. There was a significant reduction in the mean score for Physical HRQOL, but the mean score for Mental HRQOL was did not change significantly. Treatment of localized radiorecurrent PCa by salvage HIFU is associated with clinically significant reductions in urinary and sexual function domains after a mean follow-up of 17.5 months. (author)

  2. Annular and Cylindrical Phased Array Geometries for Transrectal High-Intensity Focused Ultrasound (HIFU) using PZT and Piezocomposite Materials

    Seip, Ralf; Chen, Wohsing; Carlson, Roy; Frizzell, Leon; Warren, Gary; Smith, Nadine; Saleh, Khaldon; Gerber, Gene; Shung, Kirk; Guo, Hongkai; Sanghvi, Narendra T.

    2005-03-01

    This paper presents engineering progress and the latest in-vitro and in-vivo results obtained with a 4.0 MHz, 20 element, PZT annular transrectal HIFU array and several 4.0 MHz, 211 element, PZT and piezocomposite cylindrical transrectal HIFU arrays for the treatment of prostate cancer. The geometries of both arrays were designed and analyzed to steer the HIFU beams to the desired sites in the prostate volume using multi-channel electronic drivers, with the intent to increase treatment efficiency and reliability for the next generation of HIFU systems. The annular array is able to focus in depth from 25 mm to 50 mm, generate total acoustic powers in excess of 60W, and has been integrated into a modified Sonablate®500 HIFU system capable of controlling such an applicator through custom treatment planning and execution software. Both PZT- and piezocomposite cylindrical arrays were constructed and their characteristics were compared for the transrectal applications. These arrays have been installed into appropriate transducer housings, and have undergone characterization tests to determine their total acoustic power output, focusing range (in depth and laterally), focus quality, efficiency, and comparison tests to determine the material and technology of choice (PZT or piezocomposite) for intra-cavity HIFU applications. Array descriptions, characterization results, in-vitro and in-vivo results, and an overview of their intended use through the application software is shown.

  3. Factors influencing the ablative efficiency of high intensity focused ultrasound (HIFU) treatment for adenomyosis: A retrospective study.

    Gong, Chunmei; Yang, Bin; Shi, Yarong; Liu, Zhongqiong; Wan, Lili; Zhang, Hong; Jiang, Denghua; Zhang, Lian

    2016-08-01

    Objectives The aim of this study was to investigate factors affecting ablative efficiency of high intensity focused ultrasound (HIFU) for adenomyosis. Materials and methods In all, 245 patients with adenomyosis who underwent ultrasound guided HIFU (USgHIFU) were retrospectively reviewed. All patients underwent dynamic contrast-enhanced magnetic resonance imaging (MRI) before and after HIFU treatment. The non-perfused volume (NPV) ratio, energy efficiency factor (EEF) and greyscale change were set as dependent variables, while the factors possibly affecting ablation efficiency were set as independent variables. These variables were used to build multiple regression models. Results A total of 245 patients with adenomyosis successfully completed HIFU treatment. Enhancement type on T1 weighted image (WI), abdominal wall thickness, volume of adenomyotic lesion, the number of hyperintense points, location of the uterus, and location of adenomyosis all had a linear relationship with the NPV ratio. Distance from skin to the adenomyotic lesion's ventral side, enhancement type on T1WI, volume of adenomyotic lesion, abdominal wall thickness, and signal intensity on T2WI all had a linear relationship with EEF. Location of the uterus and abdominal wall thickness also both had a linear relationship with greyscale change. Conclusion The enhancement type on T1WI, signal intensity on T2WI, volume of adenomyosis, location of the uterus and adenomyosis, number of hyperintense points, abdominal wall thickness, and distance from the skin to the adenomyotic lesion's ventral side can all be used as predictors of HIFU for adenomyosis. PMID:27385316

  4. 11C Choline PET Guided Salvage Radiotherapy with Volumetric Modulation Arc Therapy and Hypofractionation for Recurrent Prostate Cancer after HIFU Failure

    Alongi, Filippo; Liardo, Rocco L. E.; Iftode, Cristina; Lopci, Egesta; Villa, Elisa; Comito, Tiziana; Tozzi, Angelo; Navarria, Pierina; Ascolese, Anna M.; Mancosu, Pietro; Tomatis, Stefano; Bellorofonte, Carlo; Arturo, Chiti; Scorsetti, Marta

    2014-01-01

    The purpose of this work was to evaluate tolerance, feasibility and acute toxicity in patients undergoing salvage radiotherapy after high-intensity focused ultrasound (HIFU) failure. From 2005 to 2011 a total of 15 patients were treated with HIFU as primary radical treatment. Between July 2011 and February 2013, all 15 patients presented biochemical relapse after HIFU and 11C choline PET documenting intrapostatic-only failure. Salvage EBRT was performed with moderate hypofractionation schedul...

  5. Noise Pollution

    ... Overview » Title IV - Noise Pollution Title IV - Noise Pollution The 1990 Clean Air Act Amendments added a ... abatement 7642 Authorization of appropriations What is Noise Pollution? The traditional definition of noise is “unwanted or ...

  6. Ultrasound-Stimulated Acoustic Emission in Thermal Image-Guided HIFU Therapy: A Phantom Study

    Magnetic resonance image (MRI) is a promising monitoring tool for non-invasive real-time thermal guidance in high intensity focused ultrasound (HIFU) during thermal ablation surgery. However, this approach has two main drawbacks: 1) majority of components need to be redesigned to be MR compatible in order to avoid effecting MR images, and 2) the cost of operating MRI facilities is high. Alternately, ultrasound-stimulated acoustic emission (USAE) method has been applied for detecting thermal variations in tissues. An optical transparent phantom, made from polyacrylamide, containing thermal sensitive indicator protein (Bovine Serum Albumin), was prepared for observing the HIFU-induced denaturalization. A thermal-couple was set up for validation of temperature distribution. Experimental results show that thermal image can be captured clearly under stationary conditions

  7. Hydrophone spatial directivity and the induced difference in HIFU acoustic field test

    Chen, T; Zhang, D [Institute of Acoustics, Nanjing University, Nanjing 210093 (China); Hu, J M; Huang, W; Zhang, W, E-mail: Chent_qxs@jsfda.gov.cn [Jiangsu Province Institute for Medical Equipment Testing, Nanjing 210012 (China)

    2011-02-01

    Hydrophone has been widely used in testing ultrasonic field distribution. But the hydrophone has a certain directivity, which may bring error in the actual acoustic field measurements. So it is necessary to meet some requirements about the directivity of hydrophone. In the measurement, the spatial directivities of needle hydrophone, membrane hydrophone and robust hydrophone is measured and a comparison about measured data of HIFU acoustic field with them is given. Experimental results indicate that the asymmetric special directivity of hydrophone is due to manufacturing processes and other reasons. As a result, it is not sufficient to test the directivity of hydrophone along one axis. It is necessary to adjust the direction of the hydrophone when characterizing the HIFU field.

  8. Seven-Year Outcomes Following HIFU in Patients with Localized Prostate Cancer

    Uchida, Toyoaki; Shoji, Sunao; Nagata, Yoshihiro; Terachi, Toshiro; Illing, Rowland O.; Emberton, Mark

    2007-05-01

    We evaluated 409 patients suffering from localized prostate cancer treated with high-intensity focused ultrasound (HIFU). All patients were followed for at least 12 months after treatment. Biochemical failure was defined according to the criteria recommended by the American Society for Therapeutic Radiology and Oncology Consensus Panel. None of the patients received hormonal or other anticancer therapy before documentation of a biochemical failure. The biochemical disease-free rates at 5 years in patients with low, intermediate and high risk groups were 93%, 68% and 44%, respectively (pHIFU therapy appears to be a safe and efficacious minimally invasive therapy for patients with localized prostate cancer, especially those with a pretreatment PSA level less than 20 ng/ml or patients with low-risk group.

  9. Hydrophone spatial directivity and the induced difference in HIFU acoustic field test

    Hydrophone has been widely used in testing ultrasonic field distribution. But the hydrophone has a certain directivity, which may bring error in the actual acoustic field measurements. So it is necessary to meet some requirements about the directivity of hydrophone. In the measurement, the spatial directivities of needle hydrophone, membrane hydrophone and robust hydrophone is measured and a comparison about measured data of HIFU acoustic field with them is given. Experimental results indicate that the asymmetric special directivity of hydrophone is due to manufacturing processes and other reasons. As a result, it is not sufficient to test the directivity of hydrophone along one axis. It is necessary to adjust the direction of the hydrophone when characterizing the HIFU field.

  10. Modelling of the acoustic field of a multi-element HIFU array scattered by human ribs

    The efficacy of high-intensity focused ultrasound (HIFU) for the treatment of a range of different cancers, including those of the liver, prostate and breast, has been demonstrated. As a non-invasive focused therapy, HIFU offers considerable advantages over techniques such as chemotherapy and surgical resection in terms of reduced risk of harmful side effects. Despite this, there are a number of significant challenges which currently hinder its widespread clinical application. One of these challenges is the need to transmit sufficient energy through the rib cage to induce tissue necrosis in the required volume whilst minimizing the formation of side lobes. Multi-element random-phased arrays are currently showing great promise in overcoming the limitations of single-element transducers. Nevertheless, successful treatment of a patient with liver tumours requires a thorough understanding of the way in which the ultrasonic pressure field from a HIFU array is scattered by the rib cage. In order to address this, a boundary element approach based on a generalized minimal residual (GMRES) implementation of the Burton-Miller formulation was used in conjunction with phase conjugation techniques to focus the field of a 256-element random HIFU array behind human ribs at locations requiring intercostal and transcostal treatment. Simulations were carried out on a 3D mesh of quadratic pressure patches generated using CT scan anatomical data for adult ribs 9-12 on the right side. The methodology was validated on spherical and cylindrical scatterers. Field calculations were also carried out for idealized ribs, consisting of arrays of strip-like scatterers, demonstrating effects of splitting at the focus. This method has the advantage of fully accounting for the effect of scattering and diffraction in 3D under continuous wave excitation.

  11. HIFU scattering by the ribs: constrained optimisation with a complex surface impedance boundary condition

    High intensity focused ultrasound (HIFU) enables highly localised, non-invasive tissue ablation and its efficacy has been demonstrated in the treatment of a range of cancers, including those of the kidney, prostate and breast. HIFU offers the ability to treat deep-seated tumours locally, and potentially bears fewer side effects than more established treatment modalities such as resection, chemotherapy and ionising radiation. There remains however a number of significant challenges which currently hinder its widespread clinical application. One of these challenges is the need to transmit sufficient energy through the ribcage to ablate tissue at the required foci whilst minimising the formation of side lobes and sparing healthy tissue. Ribs both absorb and reflect ultrasound strongly. This sometimes results in overheating of bone and overlying tissue during treatment, leading to skin burns. Successful treatment of a patient with tumours in the upper abdomen therefore requires a thorough understanding of the way acoustic and thermal energy is deposited. Previously, a boundary element (BE) approach based on a Generalised Minimal Residual (GMRES) implementation of the Burton-Miller formulation was developed to predict the field of a multi-element HIFU array scattered by human ribs, the topology of which was obtained from CT scan data [1]. Dissipative mechanisms inside the propagating medium have since been implemented, together with a complex surface impedance condition at the surface of the ribs. A reformulation of the boundary element equations as a constrained optimisation problem was carried out to determine the complex surface velocities of a multi-element HIFU array which generated the acoustic pressure field that best fitted a required acoustic pressure distribution in a least-squares sense. This was done whilst ensuring that an acoustic dose rate parameter at the surface of the ribs was kept below a specified threshold. The methodology was tested at an

  12. Modelling of the acoustic field of a multi-element HIFU array scattered by human ribs

    Gélat, Pierre; ter Haar, Gail; Saffari, Nader

    2011-09-01

    The efficacy of high-intensity focused ultrasound (HIFU) for the treatment of a range of different cancers, including those of the liver, prostate and breast, has been demonstrated. As a non-invasive focused therapy, HIFU offers considerable advantages over techniques such as chemotherapy and surgical resection in terms of reduced risk of harmful side effects. Despite this, there are a number of significant challenges which currently hinder its widespread clinical application. One of these challenges is the need to transmit sufficient energy through the rib cage to induce tissue necrosis in the required volume whilst minimizing the formation of side lobes. Multi-element random-phased arrays are currently showing great promise in overcoming the limitations of single-element transducers. Nevertheless, successful treatment of a patient with liver tumours requires a thorough understanding of the way in which the ultrasonic pressure field from a HIFU array is scattered by the rib cage. In order to address this, a boundary element approach based on a generalized minimal residual (GMRES) implementation of the Burton-Miller formulation was used in conjunction with phase conjugation techniques to focus the field of a 256-element random HIFU array behind human ribs at locations requiring intercostal and transcostal treatment. Simulations were carried out on a 3D mesh of quadratic pressure patches generated using CT scan anatomical data for adult ribs 9-12 on the right side. The methodology was validated on spherical and cylindrical scatterers. Field calculations were also carried out for idealized ribs, consisting of arrays of strip-like scatterers, demonstrating effects of splitting at the focus. This method has the advantage of fully accounting for the effect of scattering and diffraction in 3D under continuous wave excitation.

  13. HIFU scattering by the ribs: constrained optimisation with a complex surface impedance boundary condition

    Gélat, P.; ter Haar, G.; Saffari, N.

    2014-04-01

    High intensity focused ultrasound (HIFU) enables highly localised, non-invasive tissue ablation and its efficacy has been demonstrated in the treatment of a range of cancers, including those of the kidney, prostate and breast. HIFU offers the ability to treat deep-seated tumours locally, and potentially bears fewer side effects than more established treatment modalities such as resection, chemotherapy and ionising radiation. There remains however a number of significant challenges which currently hinder its widespread clinical application. One of these challenges is the need to transmit sufficient energy through the ribcage to ablate tissue at the required foci whilst minimising the formation of side lobes and sparing healthy tissue. Ribs both absorb and reflect ultrasound strongly. This sometimes results in overheating of bone and overlying tissue during treatment, leading to skin burns. Successful treatment of a patient with tumours in the upper abdomen therefore requires a thorough understanding of the way acoustic and thermal energy is deposited. Previously, a boundary element (BE) approach based on a Generalised Minimal Residual (GMRES) implementation of the Burton-Miller formulation was developed to predict the field of a multi-element HIFU array scattered by human ribs, the topology of which was obtained from CT scan data [1]. Dissipative mechanisms inside the propagating medium have since been implemented, together with a complex surface impedance condition at the surface of the ribs. A reformulation of the boundary element equations as a constrained optimisation problem was carried out to determine the complex surface velocities of a multi-element HIFU array which generated the acoustic pressure field that best fitted a required acoustic pressure distribution in a least-squares sense. This was done whilst ensuring that an acoustic dose rate parameter at the surface of the ribs was kept below a specified threshold. The methodology was tested at an

  14. EXPERIENCE WITH A HISTOSCANNING APPARATUS USED IN THE DIAGNOSIS OF RECURRENT PROSTATE CANCER AFTER HIFU ABLATION

    P.V. Glybochko; Yu. G. Alyaev; A. V. Amosov; G. E. Krupinov; T. M. Ganzha; A. A. Obukhov; N. A. Amosov

    2012-01-01

    The new potentialities of 3D transrectal ultrasound study were realized in a HistoScanning diagnostic unit. It has been used at the R.M. Fronshtein Urology Clinic, Research Institute of Uronephrology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, since September 2011. A study of the sensitivity and specificity of the technique enrolled patients undergoing high-intensity focused ultrasound (HIFU) ablation of the prostate of for its (PC) in the period 1 to 7 years...

  15. Prostate cancer multimodal therapy involvement in couple life: Open, Robotic and HIFU approach

    Elisabeta Ioana Hirişcău; Doina Cosman; Ioan Coman

    2010-01-01

    The diagnosis and treatment of prostate cancer often results in significant physical side-effectsand associated psycho-social stressors that can interfere with the experience of sexual intimacy forcouples. Our study aims to evaluate couple’s sexual life and to determine any potential sexual dynamicdysfunctions which could occur before and after performing classic, robotic and HIFU radicalprostatectomy as a radical therapy in prostate cancer. The present article aims at the synopticpresentatio...

  16. Modelling of the acoustic field of a multi-element HIFU array scattered by human ribs

    Gelat, Pierre [National Physical Laboratory, Hampton Road, Teddington TW11 0LW (United Kingdom); Ter Haar, Gail [Therapeutic Ultrasound Group, Physics Department, Institute of Cancer Research, Sutton SM2 5NG (United Kingdom); Saffari, Nader, E-mail: Pierre.Gelat@npl.co.uk [Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE (United Kingdom)

    2011-09-07

    The efficacy of high-intensity focused ultrasound (HIFU) for the treatment of a range of different cancers, including those of the liver, prostate and breast, has been demonstrated. As a non-invasive focused therapy, HIFU offers considerable advantages over techniques such as chemotherapy and surgical resection in terms of reduced risk of harmful side effects. Despite this, there are a number of significant challenges which currently hinder its widespread clinical application. One of these challenges is the need to transmit sufficient energy through the rib cage to induce tissue necrosis in the required volume whilst minimizing the formation of side lobes. Multi-element random-phased arrays are currently showing great promise in overcoming the limitations of single-element transducers. Nevertheless, successful treatment of a patient with liver tumours requires a thorough understanding of the way in which the ultrasonic pressure field from a HIFU array is scattered by the rib cage. In order to address this, a boundary element approach based on a generalized minimal residual (GMRES) implementation of the Burton-Miller formulation was used in conjunction with phase conjugation techniques to focus the field of a 256-element random HIFU array behind human ribs at locations requiring intercostal and transcostal treatment. Simulations were carried out on a 3D mesh of quadratic pressure patches generated using CT scan anatomical data for adult ribs 9-12 on the right side. The methodology was validated on spherical and cylindrical scatterers. Field calculations were also carried out for idealized ribs, consisting of arrays of strip-like scatterers, demonstrating effects of splitting at the focus. This method has the advantage of fully accounting for the effect of scattering and diffraction in 3D under continuous wave excitation.

  17. Development and validation of a MRgHIFU non-invasive tissue acoustic property estimation technique.

    Johnson, Sara L; Dillon, Christopher; Odéen, Henrik; Parker, Dennis; Christensen, Douglas; Payne, Allison

    2016-11-01

    MR-guided high-intensity focussed ultrasound (MRgHIFU) non-invasive ablative surgeries have advanced into clinical trials for treating many pathologies and cancers. A remaining challenge of these surgeries is accurately planning and monitoring tissue heating in the face of patient-specific and dynamic acoustic properties of tissues. Currently, non-invasive measurements of acoustic properties have not been implemented in MRgHIFU treatment planning and monitoring procedures. This methods-driven study presents a technique using MR temperature imaging (MRTI) during low-temperature HIFU sonications to non-invasively estimate sample-specific acoustic absorption and speed of sound values in tissue-mimicking phantoms. Using measured thermal properties, specific absorption rate (SAR) patterns are calculated from the MRTI data and compared to simulated SAR patterns iteratively generated via the Hybrid Angular Spectrum (HAS) method. Once the error between the simulated and measured patterns is minimised, the estimated acoustic property values are compared to the true phantom values obtained via an independent technique. The estimated values are then used to simulate temperature profiles in the phantoms, and compared to experimental temperature profiles. This study demonstrates that trends in acoustic absorption and speed of sound can be non-invasively estimated with average errors of 21% and 1%, respectively. Additionally, temperature predictions using the estimated properties on average match within 1.2 °C of the experimental peak temperature rises in the phantoms. The positive results achieved in tissue-mimicking phantoms presented in this study indicate that this technique may be extended to in vivo applications, improving HIFU sonication temperature rise predictions and treatment assessment. PMID:27441427

  18. Numerical study on the effective heating due to inertial cavitation in microbubble-enhanced HIFU therapy

    Okita, Kohei; Sugiyama, Kazuyasu; Takagi, Shu; Matsumoto, Yoichiro

    2015-10-01

    The enhancement of heating due to inertial cavitation was focused in high-intensity focused ultrasound (HIFU) therapy. The influences of the rectified diffusion on microbubble-enhanced HIFU were examined numerically. A bubble dynamics equation in consideration of the spherical shell bubble and the elasticity of surrounding tissue was employed. Mass and heat transfer between the surrounding medium and the bubble were considered. The basic equations were discretized by finite difference method. The mixture phase and bubbles are coupled by the Euler-Lagrange method to take into account the interaction between ultrasound and bubbles. The mass transfer rate of gas from the surrounding medium to the bubble was examined as function of the initial bubble radius and the driving pressure amplitude. As the results, the pressure required to bubble growth was decreases with increasing the initial bubble radius. Thus, the injection of microbubble reduces the cavitation threshold pressure. On the other hand, the influence of the rectified diffusion on the triggered HIFU therapy which generates cavitation bubbles by high-intensity burst and induces the localized heating owing to cavitation bubble oscillation by low-intensity continuous waves. The calculation showed that the localized heating was enhanced by the increase of the equilibrium bubble size due to the rectified diffusion.

  19. Fast deformable registration for soft organs with large motion in HIFU treatment

    Huang, Xishi; Abdalbari, Anwar; Zaheer, Sameer; Looi, Thomas; Ren, Jing; Drake, James

    2013-03-01

    In noninvasive high intensity focused ultrasound (HIFU) treatment, we often need to register MR images acquired with different patient positioning or at different respiratory instances. In these scenarios, the abdominal organs such as the liver exhibit a large motion in different images. In our previous work, we proposed a fast neuro-fuzzy technique for deformable registration with small motion. In this study, based on elastic solid mechanics, we extend our previous results to deformation with large motion which is often the case for soft tissues in HIFU treatment. The proposed method involves minimizing strain energy of soft tissues which is constrained by 3D curves of blood vessels and point marks. It provides fast and robust deformable match for internal structures such as blood vessels, and eliminates local minima. Furthermore, the strain energy constraint provides good generalization properties, prevents the issue of overfitting, and leads to physically consistent deformable registration results. We have demonstrated the effectiveness of our deformable technique in registering MR liver images. Validation shows a target registration error of 2.31 mm and an average centerline distance error of 2.30 mm. This technique has the potential to significantly improve the registration capability and the quality of intra-operative image guidance in HIFU procedures.

  20. MRI-Guided HIFU Methods for the Ablation of Liver and Renal Cancers.

    de Senneville, Baudouin Denis; Moonen, Chrit; Ries, Mario

    2016-01-01

    MRI-guided High Intensity Focused Ultrasound (MRI-HIFU) is a promising method for the non-invasive ablation of pathological tissue in many organs, including mobile organs such as liver and kidney. The possibility to locally deposit thermal energy in a non-invasive way opens a path towards new therapeutic strategies with improved reliability and reduced associated trauma, leading to improved efficacy, reduced hospitalization and costs. Liver and kidney tumors represent a major health problem because not all patients are suitable for curative treatment with surgery. Currently, radio-frequency is the most used method for percutaneous ablation. The development of a completely non-invasive method based on MR guided high intensity focused ultrasound (HIFU) treatments is of particular interest due to the associated reduced burden for the patient, treatment related patient morbidity and complication rate. The objective of MR-guidance is hereby to control heat deposition with HIFU within the targeted pathological area, despite the physiological motion of these organs, in order to provide an effective treatment with a reduced duration and an increased level of patient safety. Regarding this, several technological challenges have to be addressed: Firstly, the anatomical location of both organs within the thoracic cage requires inter-costal ablation strategies, which preserve the therapeutic efficiency, but prevent undesired tissue damage to the ribs and the intercostal muscle. Secondly, both therapy guidance and energy deposition have to be rendered compatible with the continuous physiological motion of the abdomen. PMID:26486331

  1. High-Intensity Focused Ultrasound (HIFU) for the Treatment of Localized Prostate Cancer using Sonablate-500

    Uchida, Toyoaki; Ohkusa, Hiroshi; Yamashita, Hideyuki; Nagata, Yoshihiro

    2005-03-01

    We evaluated 181 patients with localized prostate cancer treated with high-intensity focused ultrasound (HIFU) for biochemical disease-free rate, safety, morbidity and predictors of biochemical outcome. A total of 181 patients underwent HIFU with the Sonablate-500 and with at least 12 months of follow-up. Biochemical failure was defined according to the criteria recommended by the American Society for Therapeutic Radiology and Oncology Consensus Panel. The biochemical disease-free rates at 1, 3 and 5 years in all patients were 84%, 80% and 78%, respectively. The biochemical disease-free rates at 3 years for patients with pretreatment PSA less than 10 ng/ml, 10.01 to 20.0 ng/ml and more than 20.0 ng/ml were 94%, 75% and 35%, respectively (pHIFU therapy appears to be a safe and efficacious minimally invasive therapy for patients with localized prostate cancer, especially those with a pretreatment PSA level less than 20 ng/ml.

  2. Design and Simulation of Adaptive Active Noise Control System for Aircraft Helmet%飞行头盔主动噪声控制系统的设计及仿真研究

    唐红; 王明皓; 吴凤霞

    2011-01-01

    Aiming at solving low frequency noise existing in cockpit,a design for adaptive active noise control system of aircraft helmet is proposed. Based on it,the filtered-XLMS algoritbm is simulated and analysed using MATLAB.The result shows that the effect of reducing aircraft noise on low frequency is very satisfactory with the scheme.%针对飞机驾驶舱内存在着大量的低频噪声,提出一种应用于飞行员头盔的自适应有源噪声控制系统设计方案,并在此基础上,利用MATLAB对FXLMS算法进行了仿真和性能分析。结果表明,此方案对飞机噪声低频段具有很好的降噪效果。

  3. In vivo preclinical evaluation of the accuracy of toroidal-shaped HIFU treatments using a tumor-mimic model

    The pig is an ideal animal model for preclinical evaluation of HIFU treatments, especially in the liver. However, there is no liver tumor model available for pigs. In this work, we propose to study an in vivo tumor-mimic model as a tool for evaluating if a sonographycally guided HIFU treatment, delivered by a toroidal-shaped device dedicated for the treatment of liver metastases, is correctly located in the liver. One centimeter tumor-mimics were created in liver tissues. These tumor-mimics were detectable on ultrasound imaging and on gross pathology. Two studies were carried out. First, an in vivo study of tolerance at mid-term (30 days, 10 pigs) revealed that tumor-mimics are suitable for studying HIFU treatments at a preclinical stage, since local and biological tolerances were excellent. The dimensions of the tumor-mimics were reproducible (diameter at day 0: 9.7 ± 2.0 mm) and were the same as a function of time (p = 0.64). A second in vivo study was carried out in ten pigs. Tumor mimics were used as targets in liver tissues in order to determine if the HIFU treatment is correctly located in the liver. A procedure of extensive HIFU ablation using multiple HIFU lesions juxtaposed manually was then tested on eight tumor-mimics. In 88% of the cases (seven out of eight), tumor-mimics were treated with negative margins (≥1 mm) in all directions. On average, negative margins measured 10.0 ± 6.7 mm. These tumor-mimics constitute an excellent reference for studying in vivo the accuracy of HIFU therapy in the liver.

  4. In vivo preclinical evaluation of the accuracy of toroidal-shaped HIFU treatments using a tumor-mimic model

    N' Djin, W A; Melodelima, D; Parmentier, H; Chapelon, J Y [Inserm, U556, Lyon, F-69003 (France); Universite de Lyon, Lyon, F-69003 (France); Rivoire, M [Institute of Experimental Surgery-Centre Leon Berard, Lyon, F-69008 (France); Universite de Lyon, Lyon, F-69003 (France)], E-mail: apoutou.ndjin@inserm.fr

    2010-04-21

    The pig is an ideal animal model for preclinical evaluation of HIFU treatments, especially in the liver. However, there is no liver tumor model available for pigs. In this work, we propose to study an in vivo tumor-mimic model as a tool for evaluating if a sonographycally guided HIFU treatment, delivered by a toroidal-shaped device dedicated for the treatment of liver metastases, is correctly located in the liver. One centimeter tumor-mimics were created in liver tissues. These tumor-mimics were detectable on ultrasound imaging and on gross pathology. Two studies were carried out. First, an in vivo study of tolerance at mid-term (30 days, 10 pigs) revealed that tumor-mimics are suitable for studying HIFU treatments at a preclinical stage, since local and biological tolerances were excellent. The dimensions of the tumor-mimics were reproducible (diameter at day 0: 9.7 {+-} 2.0 mm) and were the same as a function of time (p = 0.64). A second in vivo study was carried out in ten pigs. Tumor mimics were used as targets in liver tissues in order to determine if the HIFU treatment is correctly located in the liver. A procedure of extensive HIFU ablation using multiple HIFU lesions juxtaposed manually was then tested on eight tumor-mimics. In 88% of the cases (seven out of eight), tumor-mimics were treated with negative margins ({>=}1 mm) in all directions. On average, negative margins measured 10.0 {+-} 6.7 mm. These tumor-mimics constitute an excellent reference for studying in vivo the accuracy of HIFU therapy in the liver.

  5. Measurement of hearing aid internal noise1

    Lewis, James D.; Goodman, Shawn S.; Bentler, Ruth A.

    2010-01-01

    Hearing aid equivalent input noise (EIN) measures assume the primary source of internal noise to be located prior to amplification and to be constant regardless of input level. EIN will underestimate internal noise in the case that noise is generated following amplification. The present study investigated the internal noise levels of six hearing aids (HAs). Concurrent with HA processing of a speech-like stimulus with both adaptive features (acoustic feedback cancellation, digital noise reduct...

  6. Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients

    Deckers, R.; Merckel, L. G.; de Senneville, B. Denis; Schubert, G.; Köhler, M.; Knuttel, F. M.; Mali, W. P. Th M.; Moonen, C. T. W.; van den Bosch, M. A. A. J.; Bartels, L. W.

    2015-07-01

    MR-guided HIFU ablation is a promising technique for the non-invasive treatment of breast cancer. A phase I study was performed to assess the safety and treatment accuracy and precision of MR-HIFU ablation in breast cancer patients (n=10 ) using a newly developed MR-HIFU platform dedicated to applications in the breast. In this paper a technical analysis of the performance of the dedicated breast MR-HIFU system during breast tumors ablation is described. The main points of investigation were the spatial targeting accuracy and precision of the system and the performance of real-time respiration-corrected MR thermometry. The mean targeting accuracy was in the range of 2.4-2.6 mm, whereas the mean targeting precision was in the range of 1.5-1.8 mm. To correct for respiration-induced magnetic field fluctuations during MR temperature mapping a look-up-table (LUT)-based correction method was used. An optimized procedural sedation protocol in combination with the LUT-based correction method allowed for precise MR thermometry during the ablation procedure (temperature standard deviation HIFU system allows for safe, accurate and precise ablation of breast tumors.

  7. Using immunoadjuvant agent glycated chitosan to enhance anti-cancer stem like cell immunity induced by HIFU

    Chen, Y.-L.; Chen, W.-R.; Liu, R.-S.; Yang, F.-Y.; Wang, C.-Y.; Lee, Y.-J.

    2013-02-01

    Thermal therapy is based on the observation that tumor cells are sensitive to increased temperature, which is important for tumor control. In this study, the high intensity focused ultrasound (HIFU) system was used to simulate thermal therapy on breast cancer control in the small animal model. Additionally, the immunoadjuvant agent, so called glycated chitosan (GC), was used to enhance the immunological effects on tumor control. The bioluminescent imaging showed that tumor metastasis was apparently suppressed by a combined treatment using HIFU and GC, but not in HIFU or GC alone. Using immunohistochemical (IHC) staining, lung metastasis of 4T1-3R tumor cells further agree the observations obtained from non-invasive in vivo imaging. We also found that plasma collected from mice treated with combined HIFU and GC could significantly suppress the viability of cultured 4T1 cells compared to untreated or single treated group. In summary, these results suggest that the HIFU therapy combined with GC can enhance the tumor immunogenicity and tumor control.

  8. Noise Pollution

    ... EPA Home Air and Radiation Noise Pollution Noise Pollution This page has moved. You should be immediately ... gov/clean-air-act-overview/title-iv-noise-pollution Local Navigation Air & Radiation Home Basic Information Where ...

  9. FM Interference Noise Suppression Based on Adaptive Notch Filter%基于自适应陷波器的噪声调频干扰抑制方法

    路翠华; 李国林; 谢鑫

    2014-01-01

    针对线性调频引信抗噪声干扰能力比较差的问题,提出了基于自适应陷波器的噪声调频干扰抑制方法。该方法根据线性调频引信差频信号的单频特性,将自适应陷波器应用到线性调频引信中,对噪声调频干扰进行抑制。通过自适应调整陷波器的权值,使陷波器在差频信号的频率点具有陷波特性,从而达到噪声调频干扰抑制的目的。仿真结果表明:SJB=-10 dB时,仍然能达到很好的噪声调频干扰抑制效果。%Aiming at the problem that linear frequency-modulated fuze’s ability of anti-noise interference was poor,the method of noise FM interference suppression based on adaptive notch filter was presented.According to the characteristic that the difference frequency signal of linear frequency-modulated fuze was monochromatic, an adaptive notch filter was adopted to suppress FM interference noise in linear frequency-modulated fuze. Through adj usting notch filter’s weights,the notch filter has the notch characteristics in difference frequency signal's frequency,then noise FM interference was suppressed.The simulation results showed that when SJR=-10dB,FM interference noise could be still suppressed effectively.

  10. High intensity focused ultrasound (HIFU) plus percutaneous transarterial chemo-embolization (TACE) in the treatment of malignant tumors: preliminary experience of clinical application

    Objective: To evaluate the clinical effect of High intensity focused ultrasound (HIFU) combined with percutaneous transarterial Chemoembolization (TACE) in the treatment of malignant tumors. Methods: 19 patients suffering from several typical malignant tumors received the treatment of HIFU combined TAE/TACE. Evaluation was made on the clinical symptom, B-mode ultrasound, liver function test, serum AFP and MRI scan. Results: During HIFU, remarkable increased echogenicity of the tumor was revealed by realtime US. In post-procedural patients, decreased serum AFP, reduced tumor blood supply and necrosis of the mass were observed. De-bulking effect on the tumor was revealed in several patients. Conclusions: HIFU is an effective treatment of solid malignant tumors. Synergic effects take place in the HIFU combined with TACE, in which lipiodol may play an important role in the synergic effects

  11. Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU) in Treatment of Symptomatic Uterine Myomas

    Magnetic Resonance-guided High-Intensity Focused Ultrasound (MR-HIFU) is a noninvasive technique for ablation therapy for uterine myomas, where focused ultrasound energy beam generates localized high temperature in the selected area and coagulates chosen tissue, leaving the skin and tissues in between unharmed. Magnetic resonance imaging enables accurate targeting for HIFU as well as temperature monitoring during treatment. MR guidance with 3D anatomical imaging provides reference data for treatment planning, while real-time temperature monitoring aids in controlling ablation process. This review provides basic information regarding methodology, clinical indications for this kind of treatment, expected outcome and patient management during MR-HIFU procedure. The aim of this work is to introduce a new, noninvasive treatment method for uterine leiomyomas and to present a comparison with other currently used methods

  12. Usefulness of US-CT 3D dual imaging for the planning and monitoring of hepatocellular carcinoma treatment using HIFU

    Purpose: We evaluated the safety and usefulness of high-intensity focused ultrasound (HIFU) assisted by ultrasound-computed tomography three-dimensional (US-CT 3D) dual imaging for the treatment of hepatocellular carcinoma (HCC). Materials and methods: HIFU ablation was performed in 13 patients with small HCC (≤3 lesions, ≤3 cm in diameter). The HIFU system (Chongqing Haifu Tech) was used under ultrasound guidance. By transferring the sagittal or axial plane of the 3D US and the CT volume data into the ZioM900, multiplanar reconstruction images were displayed in a manner resembling conventional monitor US to assist the HIFU treatment. Results: Overall, 69% (9/13) of the patients in whom good visualization using B-mode sonography could not be obtained because of the influence of multi-reflections, rib shadows, and unclear tumor margins were successfully treated under the guidance of US-CT 3D dual imaging. In 5 of the 13 patients, multi-reflections were responsible for the poor visualization. In 2 cases, the tumor was poorly visualized because of a rib shadow. In one case, the margin of the tumor was too unclear to be detected using ultrasography. The 3D US images obtained as part of the US-CT 3D dual imaging had a high resolution and were useful for examining the area of HCC invasion and for determining the extent of the ablation area. The CT images, which are not influenced by bone shadows or multi-reflections, were useful for detecting the tumors and for visualizing the presence of the intestines in the sonication zone. HIFU treatments were successfully performed in all the patients with the assistance of US-CT 3D dual imaging. Conclusion: US-CT 3D dual imaging is useful for HIFU treatment for HCC, compensating for the occasionally poor visualization provided by US monitor.

  13. Twelve years' experience with high-intensity focused ultrasound (HIFU) using sonablate™ devices for the treatment of localized prostate cancer

    Uchida, Toyoaki; Nakano, Muyura; Shoji, Sunao; Nagata, Yoshihiro; Usui, Yukio; Terachi, Toshiro

    2012-10-01

    To report on the long-term results of high-intensity focused ultrasound (HIFU) in the treatment of localized prostate cancer. Patients with clinical Stage T1c-T3N0M0, biopsy proven, localized prostate cancer, with a serum prostate specific antigen (PSA) level of HIFU using the Sonablate™ (S) device and were required to have a minimal follow-up of 2 years after the last HIFU session to be included in this analysis. Four different generation HIFU devices, S200, S500, S500 version 4 and S500 TCM, have been used for this study. Biochemical failure was defined according to the Phoenix definition (PSA nadir+2ng/ml). Seven hundred and fifty-three men with prostate cancer were included. The patients were divided into two groups: in the Former group, 421 patients were treated with S200 and 500 from 1990 to 2005; in the Latter group, 332 patients were treated with S500 ver. 4 and TCM from 2005 to 2009. The mean age, PSA, Gleason score, operation time, and follow-up period in the Former and Latter groups were 68 and 67 years, 11.3 and 9.7 ng/ml, 6.2 and 6.6, 167 and 101 min, and 49 and 38 months, respectively. The biochemical disease-free rate (BDFR) in the groups at 5 years was, respectively, 67% and 53%, and was 50% at 10 years in the Former group (pprostate biopsy rate in the Former and Latter groups was 81% and 93%, respectively. Postoperative erectile dysfunction was noted in 45%, 38%, and 24% of patients at 6 months, 12 months, and 2 years after HIFU. The results after long-term follow-up have indicated that HIFU is an efficient and safe treatment for patients with localized prostate cancer, especially low-and intermediate-risk patients.

  14. In Vitro Validation of a Sector-Switching HIFU Device for Accelerated Treatment

    A sector-switching method that increases the HIFU sequence duty-cycle and reduces the equivalent treatment time was tested in vitro. The MR-compatible HIFU device used consisted of 2 symmetric sectors arranged on a truncated spherical cap (focus = 45 mm, long diameter = 57.5 mm, short diameter = 35 mm). A MR-compatible, 2D positioning system provided 0.5 mm accuracy. Two sonication sequences were considered, each with the same pattern for the focal point trajectory and with identical on-state power. First, both sectors radiated simultaneously, with a power duty cycle of 60%. Second, the sectors radiated separately with balanced temporally-interleaved sonication and a power duty cycle of 87.5%. Numerical simulations were performed to predict the shape of the lesion for a given set of sequence parameters, according to a theoretical model. Fast MR thermometry (voxel size: 0.85x0.85x4.25 mm3; temporal resolution: 2 sec) was performed in two orthogonal planes (sagittal and transverse) while the 2D sonication pattern was contained in the coronal plane. Fresh samples of degassed porcine liver were used, and the macroscopic lesions were measured after HIFU. The 14400 s equivalent thermal dose isolevel was compared respectively for the two sonication sequences, both with numerical simulations and experimental MR data. No susceptibility or RF artifacts could be detected on MR data. The lesion's size ratio between reference versus the sector-switched sequence was 1.12 from simulations and 1.25 (±3.2%) from MRI derived TD. Switching the device sectors reduced the treatment time by 20% while the shape and size of the lesions were maintained. In vivo studies are required for pre-clinical validation.

  15. The Feasibility of HIFU Liver Ablation Through the Ribcage and Cartilage in a Rodent Model

    King, Randy; Rieke, Viola; Pauly, Kim Butts

    2009-04-01

    We examined the feasibility of the rat model for the study of HIFU treatment of liver cancer. Significance: HIFU is being developed for the minimally invasive treatment of primary and metastatic liver cancer. In patients, obstruction of the ultrasound by the ribs poses a significant problem, and current studies are under way which investigate the efficacy of focusing around or sonicating between the ribs. Such techniques show promise for patient treatments, but are not feasible when using rodent models. Results: Six recently euthanized (within the hour) Sprague-Dewey rats were used. The hair over the anterior surface was removed. Sonications were performed with the InSightec ExAblate system at 0.95 MHz, 1.1 MHz, and 1.35MHz through the rib cage. Temperature rise was monitored with MRI-based thermometry. Lesions were created in the livers of 5/6 rats. In the five rats, energy levels between 572-1194 Joules produced lesions every time. With energies greater than 1393 Joules, skin damaged was observed which prevented the ultrasound from propagating to the liver on subsequent sonications, accounting for the one study that failed to produce lesions. No thermal damage was observed at the skin with sonications that resulted in liver lesions, and no significant heating was observed at or near the skin in the MRI temperature maps. Conclusions: It is possible to ignore the effect of ribs and sternum in rodents and create lesions within the rat liver. This technique opens the door to using hepatocellular carcinoma rodent models in HIFU studies.

  16. High intensity focused ultrasound (HIFU) therapy for local treatment of hepatocellular carcinoma: Role of partial rib resection

    Zhu Hui; Zhou Kun; Zhang Lian; Jin Chengbin; Peng Song; Yang Wei; Li Kequan; Su Haibing [Clinical Center for Tumor Therapy of 2nd Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); Chen Wenzhi [Clinical Center for Tumor Therapy of 2nd Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); State Key Laboratory, Department of Biomedical Engineering, Chongqing University of Medical Sciences, Chongqing 400037 (China); Bai Jin; Wu Feng [State Key Laboratory, Department of Biomedical Engineering, Chongqing University of Medical Sciences, Chongqing 400037 (China); National Engineering and Research Center for Ultrasound Medicine, Chongqing 401121 (China); Wang, Zhibiao [Clinical Center for Tumor Therapy of 2nd Hospital of Chongqing University of Medical Sciences, Chongqing 400010 (China); State Key Laboratory, Department of Biomedical Engineering, Chongqing University of Medical Sciences, Chongqing 400037 (China); National Engineering and Research Center for Ultrasound Medicine, Chongqing 401121 (China)], E-mail: wangzhibiao@haifu.com.cn

    2009-10-15

    Objective: It has long been known that high intensity focused ultrasound (HIFU) can kill tissue through coagulative necrosis. However, it is only in recent years that practical clinical applications are becoming possible. Since the ribs have strong reflections to ultrasonic beams, they may affect the deposition of ultrasound energy, decreasing the efficacy of HIFU treatment and increasing the chance of adverse events when the intra-abdominal tumours concealed by ribs are treated. The aim of this study was to evaluate the influence of partial rib resection on the efficacy and safety of HIFU treatment. Methods: This prospective study was approved by the ethics committee at Chongqing University of Medical Sciences. An informed consent form was obtained from each patient and family member. A total of 16 patients with hepatocellular carcinoma (HCC), consisting of 13 males and 3 females, were studied. All patients had the successful HIFU treatment. To create a better acoustic pathway for HIFU treatment, all of the 16 patients had the ribs that shield the tumour mass to be removed. Magnetic resonance imaging (MRI) was used to evaluate the efficacy of HIFU treatment. Results: Sixteen cases had 23 nodules, including 12 cases with a single nodule, 1 case with 2 nodules, 3 cases with 3 nodules. The mean diameter of tumours was 7.0 {+-} 2.1 cm (5-10 cm). According to TNM classification, 9 patients were diagnosed as stage II, 4 patients were stage III, and 3 patients were stage IV. Follow-up imaging showed an absence of tumour blood supply and shrinkage of all treated lesions. The survival rates at 1, 2, 3, 4, and 5 years were 100%, 83.3%, 69.4%, 55.6%, and 55.6%, respectively. No serious complications were observed in the patients treated with HIFU. Conclusion: Partial rib resection can create a better acoustic pathway of HIFU therapy. Even though it is an invasive treatment, this measure offers patients an improved prospect of complete tumour ablation when no other treatment

  17. High intensity focused ultrasound (HIFU) therapy for local treatment of hepatocellular carcinoma: Role of partial rib resection

    Objective: It has long been known that high intensity focused ultrasound (HIFU) can kill tissue through coagulative necrosis. However, it is only in recent years that practical clinical applications are becoming possible. Since the ribs have strong reflections to ultrasonic beams, they may affect the deposition of ultrasound energy, decreasing the efficacy of HIFU treatment and increasing the chance of adverse events when the intra-abdominal tumours concealed by ribs are treated. The aim of this study was to evaluate the influence of partial rib resection on the efficacy and safety of HIFU treatment. Methods: This prospective study was approved by the ethics committee at Chongqing University of Medical Sciences. An informed consent form was obtained from each patient and family member. A total of 16 patients with hepatocellular carcinoma (HCC), consisting of 13 males and 3 females, were studied. All patients had the successful HIFU treatment. To create a better acoustic pathway for HIFU treatment, all of the 16 patients had the ribs that shield the tumour mass to be removed. Magnetic resonance imaging (MRI) was used to evaluate the efficacy of HIFU treatment. Results: Sixteen cases had 23 nodules, including 12 cases with a single nodule, 1 case with 2 nodules, 3 cases with 3 nodules. The mean diameter of tumours was 7.0 ± 2.1 cm (5-10 cm). According to TNM classification, 9 patients were diagnosed as stage II, 4 patients were stage III, and 3 patients were stage IV. Follow-up imaging showed an absence of tumour blood supply and shrinkage of all treated lesions. The survival rates at 1, 2, 3, 4, and 5 years were 100%, 83.3%, 69.4%, 55.6%, and 55.6%, respectively. No serious complications were observed in the patients treated with HIFU. Conclusion: Partial rib resection can create a better acoustic pathway of HIFU therapy. Even though it is an invasive treatment, this measure offers patients an improved prospect of complete tumour ablation when no other treatment is

  18. Noise prevention

    Methods for noise abatement are discussed. Noise nuisance, types of noise (continuous, fluctuating, intermittent, pulsed), and types of noise abatement (absorption, vibration damping, isolation) are defined. Rockwool panels, industrial ceiling panels, baffles, acoustic foam panels, vibration dampers, acoustic mats, sandwich panels, isolating cabins and walls, ear protectors, and curtains are presented.

  19. Noise map

    Němcová, Michaela

    2015-01-01

    The aim of this paper is to introduce the measurement of noise and create a noise map in a geographic information system. The first part is focused on describing the physical properties of sound in space, atmospheric and physiological acoustics. It also deals with the physiological effects of noise on the human body and technology needed for measure and process noise. Other part describes the structure of a geographic information system and noise map. The last part is about the practical crea...

  20. Snowmobile noise

    Liikonen, Larri; Alanko, Mikko; Jokinen, Sirpa; Niskanen, Ilkka; Virrankoski, Lauri

    2007-01-01

    Planning snowmobiling routes and considering the possible need for off-road traffic restrictions requires that the noise impact of snowmobile traffic is known. The objective of this report was to take off-road readings in order to determine snowmobile noise emissions and the spread of noise from snowmobile routes into the environment. Based on the readings taken, it can be said that the noise zones created by snowmobile traffic are quite narrow at current traffic levels. Noise pollution ca...

  1. Industrial Noise

    Mehran zolfaghari

    1996-01-01

    Various risk factors in industrial environments can affect hearing status and healthy in today’s modern society. Noise control and hearing conservation program is very crucial in preventing workers exposed to high levels of noise in the work places. In the current article we are going to discuss issues such as industrial noise control, noise characteristics and standards and techniques for noise control. Then the methods for individual hearing conservation and medical care will be described i...

  2. High speed observation of HIFU-induced cavitation cloud near curved rigid boundaries

    Zuo, Z. G.; Wang, F. B.; Liu, S. H.; Wu, S. J.

    2015-01-01

    This paper focuses on the experimental study of the influence of surface curvature to the behaviour of HIFU-induced cavitation cloud. A Q-switched ruby pulse laser is used to induce cavitation nuclei in deionized water. A piezoelectric ultrasonic transducer (1.7 MHz) provides a focused ultrasound field to inspire the nucleus to cavitation cloud. A PZT probe type hydrophone is applied for measuring the HIFU sound field. It was observed that the motion of cavitation cloud located near the boundary is significantly influenced by the distance between cloud and boundary, as well as the curvature of the boundary. The curvature was defined by parameters λ and ξ. Convex boundary, concave boundary, and flat boundary correspond to ξ 1 and ξ = 1, respectively. Different behaviours of the cloud, including the migration of the cloud, the characteristics of oscillation, etc., were observed under different boundary curvatures by high-speed photography. Sonoluminescence of the acoustic cavitation bubble clouds were also studied to illustrate the characteristics of acoustic streaming.

  3. Multifunctional Bi2S3/PLGA nanocapsule for combined HIFU/radiation therapy.

    Yao, Ming-hua; Ma, Ming; Chen, Yu; Jia, Xiao-qing; Xu, Guang; Xu, Hui-xiong; Chen, Hang-rong; Wu, Rong

    2014-09-01

    A multifunctional organic-inorganic hybrid nanocapsule based on Bi2S3-embedded poly (lactic-co-glycolic acid) (PLGA) nanocapsule has been elaborately designed to combine the merits of both polymeric shell structure and Bi2S3 nanoparticles. Hydrophobic Bi2S3 nanoparticles were successfully introduced into the PLGA nanocapsules via a facile and efficient water/oil/water (W/O/W) emulsion strategy. The elastic polymeric PLGA shell provides the excellent capability of ultrasound contrast imaging to the Bi2S3/PLGA. Meanwhile, the potential of these microcapsules to enhance the high intensity focused ultrasound (HIFU) therapy was demonstrated. Importantly, this research provided the first example of both in vitro and in vivo to demonstrate the radiosensitization effect of Bi2S3-embedded PLGA hybrid nanocapsules against prostate cancer under external X-ray irradiation. Thus, the successful integration of the Bi2S3 and PLGA nanocapsules provided an alternative strategy for the highly efficient ultrasound guided HIFU/RT synergistic therapy. PMID:24973300

  4. New Devices and Promising approaches for Clinical H.I.F.U. Applications

    Tanter, Mickael; Aubry, Jean-François; Pernot, Mathieu; Marquet, Fabrice; Sinkus, Ralph; Fink, Mathias

    2007-05-01

    Bursts of focused ultrasound energy three orders of magnitude more intense than diagnostic ultrasound became during the last decade a noninvasive option for treating cancer from breast to prostate or uterin fibroid. However, many challenges remain to be addressed. First, the corrections of distortions induced on the ultrasonic therapy beam during its propagation through defocusing obstacles like skull bone or ribs remains today a technological performance that still needs to be validated clinically. Secondly, the problem of motion artifacts particularly important for the treatment of abdominal parts becomes today an important research topic. Finally, the problem of the treatment monitoring is a wide subject of interest in the growing HIFU community. For all these issues, the potential of new ultrasonic therapy devices able to work both in Transmit and Receive modes will be emphasized. A review of the work under achievement at L.O.A. using this new generation of HIFU prototypes on the monitoring, motion and aberrations corrections problems will be presented.

  5. First Experience Of Application Of High-Intensity Focused Ultrasonic Ablation (Hifu In Prostate Cancer Treatment

    A.V. Stativko

    2009-12-01

    Full Text Available The scientific article points out that 40 sessions of HIFU prostate ablation have been performed for estimation of clinical efficiency. Average frequency of influences presents 628±164 impulses; average volume of tissues subjected to influence during one procedure is 33,8±16,3 smi (132 % of prostate volume; average operation time constitutes 150 minutes (from 90 to 200 minutes. During the operation no complications have been occurred. In the first days after the session of HIFU there was a peak of PSA increase and then during 1,5-3 months there was decrease to the lowest index. Minimal PSA level was reached in 10-12 weeks after treatment and it constituted from 0,04 till 1,1 ngml depending on the disease state. Reduction of prostate volume occurred in average from the 30th day of postoperative period and lasted for 6 months, reaching in average 50 % from initial volume. Postoperative period varied from 10 till 16 days and constituted in average 12±0,8 days. Thus application of high-intensity focused ultrasonic ablation allows treating successfully various stages of prostate cancer with minimal number of side-effects and makes possible the early estimation of treatment efficiency

  6. Monitoring high-intensity focused ultrasound (HIFU) therapy using radio frequency ultrasound backscatter to quantify heating

    Kaczkowski, Peter J.; Anand, Ajay

    2005-09-01

    The spatial distribution and temporal history of tissue temperature is an essential indicator of thermal therapy progress, and treatment safety and efficacy. Magnetic resonance methods provide the gold standard noninvasive measurement of temperature but are costly and cumbersome compared to the therapy itself. We have been developing the use of ultrasound backscattering for real-time temperature estimation; ultrasonic methods have been limited to relatively low temperature rise, primarily due to lack of sensitivity at protein denaturation temperatures (50-70°C). Through validation experiments on gel phantoms and ex vivo tissue we show that temperature rise can be accurately mapped throughout the therapeutic temperature range using a new BioHeat Transfer Equation (BHTE) model-constrained inverse approach. Speckle-free temperature and thermal dose maps are generated using the ultrasound calibrated model over the imaged region throughout therapy delivery and post-treatment cooling periods. Results of turkey breast tissue experiments are presented for static HIFU exposures, in which the ultrasound calibrated BHTE temperature maps are shown to be very accurate (within a degree) using independent thermocouple measurements. This new temperature monitoring method may speed clinical adoption of ultrasound-guided HIFU therapy. [Work supported by Army MRMC.

  7. A History of the Sonocare CST-100: The First FDA-approved HIFU Device

    Muratore, Robert

    2006-05-01

    The Sonocare CST-100 Therapeutic Ultrasound System, designed for the treatment of glaucoma, was developed in the 1980s and became the first high intensity focused ultrasound (HIFU) device to receive Food and Drug Administration approval. The system arose from studies done by F.L. Lizzi, Eng.Sc.D., of Riverside Research Institute and D.J. Coleman, M.D., of Cornell Medical Center/New York Hospital on the safety of ultrasound diagnosis of the eye. As safety limits were probed, therapeutic regimes were discovered. Optimization of operational parameters, clinical experience, and engineering design came together through a spin-off company, Sonocare, Inc., formed to produce and market the ophthalmic device. Various precedents were set during the approval process, including the acceptance by the FDA of radiation momentum imparted to an absorber as a measure of acoustic power. Many devices were sold, but the laser industry, grandfathered into the therapeutic field, eventually out-marketed Sonocare. The CST-100 remains as a model of elegant industrial design, and existing units are used daily in HIFU laboratory experiments.

  8. 环境噪音对鸟类鸣声的影响及鸟类的适应对策%Impacts of ambient noise on bird song and adaptation strategies of birds

    季婷; 张雁云

    2011-01-01

    For the animals living in the areas with high level ambient noise, their call signals could be overlapped with the frequency, amplitude , and temporal characters of the noise , making the spread efficiency of the animals acoustic signals decreased. Birds mainly rely on their songs for communication. The lower level spread efficiency of their acoustic signal will impact their individual recognition, mate selection, territorial defense, population density, community structure, and so on. This paper summarized the impacts of ambient noise, including urban noise and natural noise, on bird song and the adaptation strategies of birds, pointed out the concerns of these impacts in urbanization, and prospected the possible hotspots in the future research.%在高噪音环境中生存的动物,发出的声信号会与噪声的频率、振幅和时间等重叠,使动物声信号的传播效率降低.鸟类主要靠鸣声通讯,鸣声传播效率下降会影响鸟类个体间识别、配偶关系、领域防卫、种群密度、群落结构等.本文综述了城市噪音、自然噪音等环境噪声对鸟类鸣声的影响以及鸟类的适应对策,提出在城市化进程中要关注噪音对鸟类的影响,并展望了本领域今后可能的研究热点.

  9. An Ultrasound Image-Based Dynamic Fusion Modeling Method for Predicting the Quantitative Impact of In Vivo Liver Motion on Intraoperative HIFU Therapies: Investigations in a Porcine Model.

    W Apoutou N'Djin

    Full Text Available Organ motion is a key component in the treatment of abdominal tumors by High Intensity Focused Ultrasound (HIFU, since it may influence the safety, efficacy and treatment time. Here we report the development in a porcine model of an Ultrasound (US image-based dynamic fusion modeling method for predicting the effect of in vivo motion on intraoperative HIFU treatments performed in the liver in conjunction with surgery. A speckle tracking method was used on US images to quantify in vivo liver motions occurring intraoperatively during breathing and apnea. A fusion modeling of HIFU treatments was implemented by merging dynamic in vivo motion data in a numerical modeling of HIFU treatments. Two HIFU strategies were studied: a spherical focusing delivering 49 juxtapositions of 5-second HIFU exposures and a toroidal focusing using 1 single 40-second HIFU exposure. Liver motions during breathing were spatially homogenous and could be approximated to a rigid motion mainly encountered in the cranial-caudal direction (f = 0.20 Hz, magnitude > 13 mm. Elastic liver motions due to cardiovascular activity, although negligible, were detectable near millimeter-wide sus-hepatic veins (f = 0.96 Hz, magnitude 75%. Fusion modeling predictions were preliminarily validated in vivo and showed the potential of using a long-duration toroidal HIFU exposure to accelerate the ablation process during breathing (from 0.5 to 6 cm3 · min(-1. To improve HIFU treatment control, dynamic fusion modeling may be interesting for assessing numerically focusing strategies and motion compensation techniques in more realistic conditions.

  10. A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo- Synergistic Cancer Therapy

    Zhang, Nan; Cai, Xiaojun; Gao, Wei; Wang, Ronghui; Xu, Chunyan; Yao, Yuanzhi; Hao, Lan; Sheng, Danli; Chen, Hangrong; Wang, Zhigang; Zheng, Yuanyi

    2016-01-01

    High-intensity focused ultrasound (HIFU) is deemed to be a promising noninvasive therapeutic modality for cancers as well as non-neoplastic diseases. However, the accuracy of the technique in the diagnosis and treatment of tumors remains unsatisfactory. HIFU, when combined with multifunctional synergistic agents (SAs), has the potential to be of greater diagnostic and therapeutic efficacy. Here we describe a smart and multifunctional hollow mesoporous Prussian blue (HMPBs) theranostic nanoplatform, the hollow structure of which is capable of encapsulating doxorubicin (DOX) and perfluorohexane (HMPBs-DOX/PFH). In vitro and in vivo studies validated that HMPBs-DOX/PFH can be used as an amplifiable dual-mode imaging contrast agent, which can simultaneously enhance ultrasound (US) and photoacoustic (PA) imaging for guiding and monitoring tumor therapy. When exposed to HIFU, this versatile HMPBs-DOX/PFH agent could increase the cavitation effect and use lower HIFU intensity to achieve coagulative necrosis. Furthermore, it significantly accelerated the release of DOX thereby enhancing chemotherapeutic efficacy and avoiding systemic side effects of the drug. Such a novel theranostic nanoplatform is expected to integrate dual-mode guided imaging with greater therapeutic efficacy and fewer side effects and is very promising for the noninvasive synergistic tumor therapy. PMID:26909114

  11. Respiratory-Gated MRgHIFU in Upper Abdomen Using an MR-Compatible In-Bore Digital Camera

    Vincent Auboiroux

    2014-01-01

    Full Text Available Objective. To demonstrate the technical feasibility and the potential interest of using a digital optical camera inside the MR magnet bore for monitoring the breathing cycle and subsequently gating the PRFS MR thermometry, MR-ARFI measurement, and MRgHIFU sonication in the upper abdomen. Materials and Methods. A digital camera was reengineered to remove its magnetic parts and was further equipped with a 7 m long USB cable. The system was electromagnetically shielded and operated inside the bore of a closed 3T clinical scanner. Suitable triggers were generated based on real-time motion analysis of the images produced by the camera (resolution 640×480 pixels, 30 fps. Respiratory-gated MR-ARFI prepared MRgHIFU ablation was performed in the kidney and liver of two sheep in vivo, under general anaesthesia and ventilator-driven forced breathing. Results. The optical device demonstrated very good MR compatibility. The current setup permitted the acquisition of motion artefact-free and high resolution MR 2D ARFI and multiplanar interleaved PRFS thermometry (average SNR 30 in liver and 56 in kidney. Microscopic histology indicated precise focal lesions with sharply delineated margins following the respiratory-gated HIFU sonications. Conclusion. The proof-of-concept for respiratory motion management in MRgHIFU using an in-bore digital camera has been validated in vivo.

  12. 一种基于自适应滤波器的潜艇辐射噪声仿真方法%A Simulation Method for Submarine Radiation Noise Based on Adaptive Filter

    孙时珍

    2013-01-01

      文章提出了一种基于自适应滤波器的潜艇辐射噪声仿真方法。在对潜艇辐射噪声连续谱、线谱和调制谱的数学模型进行研究的基础上,利用Ecs型功率谱模型,基于自适应滤波器,通过傅里叶反变换对潜艇辐射噪声连续谱进行了仿真,分别叠加了线谱信号和调制谱信号之后,得到潜艇辐射噪声的仿真结果。通过对仿真结果的分析和利用仿真结果与实装进行对接测试,表明仿真的辐射噪声逼真度较高。%A simulation method for submarine radiation noise based on adaptive filter was proposed. Based on the research on the mathematical models of continuous spectrum, line spectrum and modulation spectrum of sub⁃marine radiation noise, the continuous spectrum of submarine radiation noise was simulated via inverse fourier transform based on adaptive filter using Ecs spectrum model. The simulation results was obtained after superpose⁃ing the line sepctrum signal and modulation signal. The analysis and equipment test of the simulation results showed that its naturalness was so good that the method was practical.

  13. Unjust noise

    Paul Voice

    2009-01-01

    In this paper I argue that noise is a significant source of social harm and thoseharmed by noise often suffer not merely a misfortune but an injustice. I arguethat noise is a problem of justice in two ways; firstly, noise is a burden of socialcooperation and so the question of the distribution of this burden arises. And,secondly, some noises, although burdensome, are nevertheless just becausethey arise from practices that are ‘reasonable’. I offer a number of distinctions,between necessary an...

  14. Development of Active Noise Control System for Quieting Transformer Noise

    Lee, Bok Kyu; Song, Seik Young; Choi, Huo Yul [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Yun, Dae Hea; Lee, Hyuk Jae [Korea Electrotechnology Research Institute, Changwon (Korea, Republic of)

    1997-12-31

    The passive noise control technique made use of sound-absorbing or soundproofing materials, so it required a large area and high cost for installation and had a drawback of poor performance at low frequency. Compared to this, the Active Noise Control attenuates noise sound pressure by using secondary source which has same performance ay low-frequency. Furthermore, it is able to save space and expenses. - research on adaptive algorithms - evaluation of global attenuation of the control - computer simulation - real-time Active Noise Control System Hardware Implementation - ANC system setting in the noisy area.

  15. High-Intensity Focused Ultrasound (HIFU) Using Sonablate® Devices for the Treatment of Benign Prostatic Hyperplasia and Localized Prostate Cancer: 18-year experience

    Uchida, Toyoaki

    2011-09-01

    From 1993 to 2010, we have treated 156 patients benign prostatic hyperplasia (BPH) and 1,052 patients localized prostate cancer high-intensity focused ultrasound (HIFU). Four different HIFU devices, SonablateR-200, SonablateR-500, SonablateR-500 version 4 and Sonablate® TCM, have been used for this study. Clinical outcome of HIFU for BPH did not show any superior effects to transurethral resection of the prostate, laser surgery or transurethral vapolization of the prostate. However, HIFU appears to be a safe and minimally invasive therapy for patients with localized prostate cancer, especially low- and intermediate-risk patients. The rate of clinical outcome has significantly improved over the years due to technical improvements in the device.

  16. Rotor noise

    Schmitz, F. H.

    1991-01-01

    The physical characteristics and sources of rotorcraft noise as they exist today are presented. Emphasis is on helicopter-like vehicles, that is, on rotorcraft in nonaxial flight. The mechanisms of rotor noise are reviewed in a simple physical manner for the most dominant sources of rotorcraft noise. With simple models, the characteristic time- and frequency-domain features of these noise sources are presented for idealized cases. Full-scale data on several rotorcraft are then reviewed to allow for the easy identification of the type and extent of the radiating noise. Methods and limitations of using scaled models to test for several noise sources are subsequently presented. Theoretical prediction methods are then discussed and compared with experimental data taken under very controlled conditions. Finally, some promising noise reduction technology is reviewed.

  17. Visual Investigation of Heating Effect in Liver and Lung Induced by a HIFU Transducer

    Karaböce, B.; Durmuş, H. O.

    The heating effect produced by a focused ultrasound transducer has been investigated by using visual techniques with a positioning system. Ultrasound power, distance, frequency and harmonics of heating effect was investigated. Three experiments were performed on TMM (Tissue Mimicking Material), sheep liver and sheep lung. HIFU (High Intensity Focused Ultrasound) transducer with a resonance frequency of 1.1 MHz and 3.3 MHz was used as source. Effect of ultrasound in liver and lung's pieces were displayed and dimension of cauterization has been measured. Previous temperature measurement results for TMM were compared with liver and lung measurement results so that it is possible to transfer the laboratory measurements to the clinical studies. All measurements were carried out in the system at TÜBİTAK UME (The Scientific and Technological Research Council of Turkey, the National Metrology Institute) Ultrasound laboratory.

  18. Interference-free ultrasound imaging during HIFU therapy, using software tools

    Vaezy, Shahram (Inventor); Held, Robert (Inventor); Sikdar, Siddhartha (Inventor); Managuli, Ravi (Inventor); Zderic, Vesna (Inventor)

    2010-01-01

    Disclosed herein is a method for obtaining a composite interference-free ultrasound image when non-imaging ultrasound waves would otherwise interfere with ultrasound imaging. A conventional ultrasound imaging system is used to collect frames of ultrasound image data in the presence of non-imaging ultrasound waves, such as high-intensity focused ultrasound (HIFU). The frames are directed to a processor that analyzes the frames to identify portions of the frame that are interference-free. Interference-free portions of a plurality of different ultrasound image frames are combined to generate a single composite interference-free ultrasound image that is displayed to a user. In this approach, a frequency of the non-imaging ultrasound waves is offset relative to a frequency of the ultrasound imaging waves, such that the interference introduced by the non-imaging ultrasound waves appears in a different portion of the frames.

  19. The physical acoustics of HIFU exposure: A suite of in vitro studies

    Roy, Ronald A.; Holt, R. Glynn; Cleveland, Robin O.

    2001-05-01

    Exposing tissue and blood media to high-intensity focused ultrasound leads to a broad range of physical and biological effects. In addition to tissue heating from thermo-viscous absorption, one encounters nonlinear and second order phenomena such as wave-front shocking, radiation stress, acoustic streaming, bubble nucleation and cavitation. All of these processes impact one's ability to effect controlled tissue heating. This paper reviews a suite of studies under way at Boston University that focus on developing a quantitative understanding of the physical acoustics of high-intensity focused ultrasound. We describe research into HIFU heating and both uniform and flow-through tissue phantom and address the potentially critical roles played by bubbles and acoustic cavitation. [Work supported by the U.S. Army and the Center for Subsurface Sensing and Imaging Systems via NSF ERC Award No. EEC-9986821.

  20. Towards the use of HIFU, in Conjunction with Surgery, in the Treatment of Malignant Brain Tumors

    Dahl, Elizabeth; Nguyen, Lisa T.; Sparks, Rachel E.; Brayman, Andy A.; Olios, Ryan J.; Silbergeld, Daniel L.; Vaezy, Sarah; Mourad, Pierre D.

    2006-05-01

    The first medical response to the presence of a brain tumor is often its resection, both to alleviate mass effect, and to obtain tissue for diagnosis, itself necessary for guiding adjunctive therapy. Malignant brain tumors typically recur at the tumor resection margin. Most current chemotherapy and radiotherapy strategies target local recurrence with limited success. Here we review a new strategy for delivering chemotherapeutics for brain tumor recurrence. It uses intra-operative high-intensity focused ultrasound (HIFU) to transiently open the blood-brain barrier (BBB) over a significantly large volume of brain at and near the resection margin to enhance the subsequent delivery of systemically delivered chemotherapeutic agents into the region of tumor recurrence.

  1. Predicting and Preventing Skull Overheating in Non Invasive Brain HIFU Treatment Protocols

    Ultrasound brain therapy is currently limited by the strong phase and amplitude aberrations induced by the heterogeneities of the skull. However the development of aberration correction techniques has made it possible to correct the beam distortion induced by the skull and to produce a sharp focus in the brain. Moreover, using the density of the skull bone that can be obtained with high-resolution CT scans, the corrections needed to produce this sharp focus can be calculated using ultrasound propagation models. We propose here a model for computing the temperature elevation in the skull during High Intensity Focused Ultrasound (HIFU) transcranial therapy. Based on CT scans, the wave propagation through the skull is computed with 3D finite differences wave propagation software. The acoustic simulation is combined with a 3D thermal diffusion code and the temperature elevation inside the skull is computed. Finally, the simulation is validated experimentally by measuring the temperature elevation in several locations of the skull

  2. An Ultrasound Image-Based Dynamic Fusion Modeling Method for Predicting the Quantitative Impact of In Vivo Liver Motion on Intraoperative HIFU Therapies: Investigations in a Porcine Model

    N'Djin, W. Apoutou; Chapelon, Jean-Yves; Melodelima, David

    2015-01-01

    Organ motion is a key component in the treatment of abdominal tumors by High Intensity Focused Ultrasound (HIFU), since it may influence the safety, efficacy and treatment time. Here we report the development in a porcine model of an Ultrasound (US) image-based dynamic fusion modeling method for predicting the effect of in vivo motion on intraoperative HIFU treatments performed in the liver in conjunction with surgery. A speckle tracking method was used on US images to quantify in vivo liver ...

  3. Real-Time Tissue Change Monitoring on the Sonablate® 500 during High Intensity Focused Ultrasound (HIFU) Treatment of Prostate Cancer

    Chen, Wo-Hsing; Sanghvi, Narendra T.; Carlson, Roy; Uchida, Toyoaki

    2011-09-01

    Sonablate® 500 (SB-500) HIFU devices have been successfully used to treat prostate cancer non-invasively. In addition, Visually Directed HIFU with the SB-500 has demonstrated higher efficacy. Visually Directed HIFU works by displaying hyperechoic changes on the B-mode ultrasound images. However, small changes in the grey-scale images are not detectable by Visually Directed HIFU. To detect all tissue changes reliably, the SB-500 was enhanced with quantitative, real-time Tissue Change Monitoring (TCM) software. TCM uses pulse-echo ultrasound backscattered RF signals in 2D to estimate changes in the tissue properties caused by HIFU. The RF signal energy difference is calculated in selected frequency bands (pre and post HIFU) for each treatment site. The results are overlaid on the real-time ultrasound image in green, yellow and orange to represent low, medium and high degree of change in backscattered energy levels. The color mapping scheme was derived on measured temperature and backscattered RF signals from in vitro chicken tissue experiments. The TCM software was installed and tested in a clinical device to obtain human RF data. Post HIFU contrast enhanced MRI scans verified necrotic regions of the prostate. The color mapping success rate at higher HIFU power levels was 94% in the initial clinical test. Based on these results, TCM software has been released for wider usage. The clinical studies with TCM in Japan and The Bahamas have provided the following PSA (ng/ml) results. Japan (n = 97), PSA pre-treatment/post-treatment; minimum 0.7/0.0, maximum 76.0/4.73, median 6.89/0.07, standard deviation 11.19/0.62. The Bahamas (n = 59), minimum 0.4/0.0, maximum 13.0/1.4, median 4.7/0.1, standard deviation 2.8/0.3.

  4. Transrectal high-intensity focused ultrasound (HIFU) treatment of localized prostate cancer: Review of technical incidents and morbidity after 5 years of use

    RIPERT, Thomas; AZEMAR, Marie Dominique; MENARD, Johann; BAYOUD, Younes; Messaoudi, Rabah; Duval, François; Staerman, Frédéric

    2010-01-01

    Abstract OBJECTIVE To report on technical incidents, and early and late complications, occurring on high-intensity focused ultrasound (HIFU) treatment of patients with localized prostate cancer. PATIENTS AND METHODS We performed a retrospective review of patients who were treated by Ablatherm? in our centre. We recorded all technical incidents, treatment discontinuations, and early (< 1 month) and late complications. RESULTS A total of 74 HIFU procedures were perfor...

  5. Voltage fluctuations in neurons: signal or noise?

    Yarom, Yosef; Hounsgaard, Jorn

    2011-01-01

    , we discuss noise-free neuronal signaling and detrimental and beneficial forms of noise in large-scale functional neural networks. Evidence that noise and variability in some cases go hand in hand with behavioral variability and increase behavioral choice, richness, and adaptability opens new avenues...

  6. Prognostic factors in the estimation of HIFU treatment efficiency in patients with localized prostate cancer

    Popkov V.M.

    2013-03-01

    Full Text Available Research objective: To study the role of prognostic factors in the estimation of risk development of recurrent prostate cancer after treatment by high-intensive focused ultrasound (HIUF. Objects and Research Methods: The research has included 102 patients with morphologically revealed localized prostate cancer by biopsy. They have been on treatment in Clinic of Urology of the Saratov Clinical Hospital n.a. S. R. Mirotvortsev. 102 sessions of initial operative treatment of prostate cancer by the method of HIFU have been performed. The general group of patients (n=102 has been subdivided by the method of casual distribution into two samples: group of patients with absent recurrent tumor and group of patients with the revealed recurrent tumor, by morphological research of biopsy material of residual prostate tissue after HIFU. The computer program has been used to study the signs of outcome of patients with prostate cancer. Results: Risk of development of recurrent prostate cancer has grown with the PSA level raise and its density. The index of positive biopsy columns <0,2 has shown the recurrence of prostate cancer in 17% cases while occurrence of prostate cancer in 59% cases has been determined by the index of 0,5 and higher. The tendency to obvious growth of number of relapses has been revealed by the sum of Glison raise with present perineural invasion. Cases of recurrent prostate cancer have been predominant in patients with lymphovascular invasions. In conclusion it has been worked out that the main signs of recurrent prostate cancer development may include: PSA, PSA density, the sum of Glison, lymphovascular invasion, invasion.

  7. Noise and mental performance: personality attributes and noise sensitivity.

    Belojevic, G; Jakovljevic, B; Slepcevic, V

    2003-01-01

    The contradictory and confusing results in noise research on humans may partly be due to individual differences between the subjects participating in different studies. This review is based on a twelve year research on the role of neuroticism, extroversion and subjective noise sensitivity during mental work in noisy environment. Neurotic persons might show enhanced "arousability" i.e. their arousal level increases more in stress. Additional unfavorable factors for neurotics are worrying and anxiety, which might prevent them coping successfully with noise, or some other stressors during mental performance. In numerous experiments introverts have showed higher sensitivity to noise during mental performance compared to extroverts, while extroverts often cope with a boring task even by requesting short periods of noise during performance. Correlation analyses have regularly revealed a highly significant negative relation between extroversion and noise annoyance during mental processing. Numerous studies have shown that people with high noise sensitivity may be prevented from achieving the same work results as other people in noisy environment, thus leading to psychosomatic, neurotic or other difficulties. Positive relation between noise annoyance and subjective noise sensitivity might be very strong. Our results have shown, after matching with the results of other relevant studies, that more stable personality, with extroversive tendencies and with a relatively lower subjective noise sensitivity measured with standard questionnaires, may be expected to better adapt to noise during mental performance, compared to people with opposite personality traits. PMID:14965455

  8. Noise suppression method for received waveform of satellite laser altimeter based on adaptive filter%利用自适应滤波星载激光测高仪回波噪声抑制方法

    马跃; 李松; 周辉; 翁寅侃

    2012-01-01

    For satellite laser altimeter, the range between earth surface and satellite platform could be calculated, and the target characters could be inversed through extracting the parameters of received waveforms. The signal degradations emerge on the noise suppression process of returned pulse using the fixed width Gaussian filter, which influences seriously the extracting of the effective parameters. Based on the different statistical regularities among blocked signal, a new method is presented to estimate the mean and standard deviation of returned waveforms, and a width adaptive Gaussian filter is designed according to the statistical characters of returned pulse. The received digital counts data of GLAS were used to the Noise estimation, adaptive Gaussian filter, and Gaussian fitting were measured by GLAS system. The calculation results accord with GLAS official statstics. The errors of estimated noise mean were less than 0.4 digitized unit, and the effective Gaussian parameter errors are less dian 1%. The conclusion is that the returned pulse parameters of laser altimeter could be extracted effectively and accurately through this noise suppression method.%具有波形记录功能的星载激光测高仪,通过回波信息解算地表与卫星平台距离和反演地物特性.目前广泛采用的固定宽度高斯滤波方法在抑制回波噪声过程中造成有效信号变形,对提取信号有效参量造成严重干扰.根据分块信号统计特性不同的规律,提出了激光测高仪回波噪声均值和方差的估计方法;根据回波信号的统计特性,设计了一种宽度自适应的高斯滤波器.通过GLAS系统实测回波信号的噪声估计与自适应高斯滤波、高斯拟合,得到的波形处理结果与GLAS官方数据有很好的吻合度,噪声均值估计误差小于0.4个数字化仪单位,有效高斯参数计算误差小于1%.该方法能准确地提取波形参量,为地表高程解算和目标表面信息反演提供有效数据.

  9. Feminizing noise

    Thompson, Marie

    2014-01-01

    Marie will explore the relationship between constructions of femininity and noise, which is understood here as an affective transformative force, rather than simply as unwanted sound. She will suggest that ‘feminine’ noises are often deemed negative; not because of what they mean, but as a result of the transformations they threaten to induce. Marie will raise questions around essentialism – does talking of a feminine or feminized noise require us to adopt an essentialist position, or can an ...

  10. NOISE REGULATION

    Cristina Voican; Constantin Stanescu

    2012-01-01

    Noise regulation includes statutes or guidelines relating to sound transmission established by national, state or provincial and municipal levels of government. After the watershed passage of the United States Noise Control Act of 1972, other local and state governments passed further regulations. Although the UK and Japan enacted national laws in 1960 and 1967 respectively, these laws were not at all comprehensive or fully enforceable as to address generally rising ambient noise, enforceable...

  11. Towards noise classification of road pavements

    Freitas, Elisabete F.; Paulo, Joel; Coelho, J. L. Bento; Pereira, Paulo A. A.

    2008-01-01

    Noise classification of road surfaces has been addressed in many European countries. This paper presents the first approach towards noise classification of Portuguese road pavements. In this early stage, it aims at establishing guidelines for decision makers to support their noise reduction policies and the development of a classification system adapted to the European recommendations. A ranking to provide guidance on tire-road noise emission levels for immediate use by decisio...

  12. Respiratory-Gated MRgHIFU in Upper Abdomen Using an MR-Compatible In-Bore Digital Camera

    Vincent Auboiroux; Lorena Petrusca; Magalie Viallon; Arnaud Muller; Sylvain Terraz; Romain Breguet; Xavier Montet; Becker, Christoph D; Rares Salomir

    2014-01-01

    Objective. To demonstrate the technical feasibility and the potential interest of using a digital optical camera inside the MR magnet bore for monitoring the breathing cycle and subsequently gating the PRFS MR thermometry, MR-ARFI measurement, and MRgHIFU sonication in the upper abdomen. Materials and Methods. A digital camera was reengineered to remove its magnetic parts and was further equipped with a 7 m long USB cable. The system was electromagnetically shielded and operated inside the bo...

  13. ECG De-noising

    Kærgaard, Kevin; Jensen, Søren Hjøllund; Puthusserypady, Sadasivan

    2015-01-01

    Electrocardiogram (ECG) is a widely used noninvasive method to study the rhythmic activity of the heart and thereby to detect the abnormalities. However, these signals are often obscured by artifacts from various sources and minimization of these artifacts are of paramount important. This paper...... proposes two adaptive techniques, namely the EEMD-BLMS (Ensemble Empirical Mode Decomposition in conjunction with the Block Least Mean Square algorithm) and DWT-NN (Discrete Wavelet Transform followed by Neural Network) methods in minimizing the artifacts from recorded ECG signals, and compares their...... performance. These methods were first compared on two types of simulated noise corrupted ECG signals: Type-I (desired ECG+noise frequencies outside the ECG frequency band) and Type-II (ECG+noise frequencies both inside and outside the ECG frequency band). Subsequently, they were tested on real ECG recordings...

  14. Aircraft Noise

    Michel, Ulf; Dobrzynski, Werner; Splettstoesser, Wolf; Delfs, Jan; Isermann, Ullrich; Obermeier, Frank

    Aircraft industry is exposed to increasing public pressure aiming at a continuing reduction of aircraft noise levels. This is necessary to both compensate for the detrimental effect on noise of the expected increase in air traffic and improve the quality of living in residential areas around airports.

  15. Noise Traders

    James Dow; Gary Gorton

    2006-01-01

    Noise traders are agents whose theoretical existence has been hypothesized as a way of solving certain fundamental problems in Financial Economics. We briefly review the literature on noise traders. The is an entry for The New Palgrave: A Dictionary of Economics, 2nd Edition (Palgrave Macmillan: New York), edited by Steven N. Durlauf and Lawrence E. Blume, forthcoming in 2008.

  16. Real-time temperature estimation and monitoring of HIFU ablation through a combined modeling and passive acoustic mapping approach

    Jensen, C. R.; Cleveland, R. O.; Coussios, C. C.

    2013-09-01

    Passive acoustic mapping (PAM) has been recently demonstrated as a method of monitoring focused ultrasound therapy by reconstructing the emissions created by inertially cavitating bubbles (Jensen et al 2012 Radiology 262 252-61). The published method sums energy emitted by cavitation from the focal region within the tissue and uses a threshold to determine when sufficient energy has been delivered for ablation. The present work builds on this approach to provide a high-intensity focused ultrasound (HIFU) treatment monitoring software that displays both real-time temperature maps and a prediction of the ablated tissue region. This is achieved by determining heat deposition from two sources: (i) acoustic absorption of the primary HIFU beam which is calculated via a nonlinear model, and (ii) absorption of energy from bubble acoustic emissions which is estimated from measurements. The two sources of heat are used as inputs to the bioheat equation that gives an estimate of the temperature of the tissue as well as estimates of tissue ablation. The method has been applied to ex vivo ox liver samples and the estimated temperature is compared to the measured temperature and shows good agreement, capturing the effect of cavitation-enhanced heating on temperature evolution. In conclusion, it is demonstrated that by using PAM and predictions of heating it is possible to produce an evolving estimate of cell death during exposure in order to guide treatment for monitoring ablative HIFU therapy. Portions presented at the 13th International Symposium on Therapeutic Ultrasound, Heidelberg, Germany (2012).

  17. Real-time temperature estimation and monitoring of HIFU ablation through a combined modeling and passive acoustic mapping approach

    Passive acoustic mapping (PAM) has been recently demonstrated as a method of monitoring focused ultrasound therapy by reconstructing the emissions created by inertially cavitating bubbles (Jensen et al 2012 Radiology 262 252–61). The published method sums energy emitted by cavitation from the focal region within the tissue and uses a threshold to determine when sufficient energy has been delivered for ablation. The present work builds on this approach to provide a high-intensity focused ultrasound (HIFU) treatment monitoring software that displays both real-time temperature maps and a prediction of the ablated tissue region. This is achieved by determining heat deposition from two sources: (i) acoustic absorption of the primary HIFU beam which is calculated via a nonlinear model, and (ii) absorption of energy from bubble acoustic emissions which is estimated from measurements. The two sources of heat are used as inputs to the bioheat equation that gives an estimate of the temperature of the tissue as well as estimates of tissue ablation. The method has been applied to ex vivo ox liver samples and the estimated temperature is compared to the measured temperature and shows good agreement, capturing the effect of cavitation-enhanced heating on temperature evolution. In conclusion, it is demonstrated that by using PAM and predictions of heating it is possible to produce an evolving estimate of cell death during exposure in order to guide treatment for monitoring ablative HIFU therapy. (paper)

  18. High-Intensity Focused Ultrasound (HIFU) Using Sonablate-500 for the Treatment of Localized Prostate Cancer: 6-year experience

    Uchida, Toyoaki; Shoji, Sunao; Nagata, Yoshihiro

    2006-05-01

    We evaluated 281 patients of localized prostate cancer treated with high-intensity focused ultrasound (HIFU) for biochemical disease-free rate, safety, morbidity and predictors of biochemical outcome. A total of 281 patients underwent HIFU with the use of Sonablate-500 and with at least 12 months of follow-up. Biochemical failure was defined according to the criteria recommended by the American Society for Therapeutic Radiology and Oncology Consensus Panel. The biochemical disease-free rates at 1, 3 and 5 years in all patients were 78%, 74% and 72%, respectively. The biochemical disease-free rates at 5 years for patients with pretreatment PSA less than 10 ng/ml, 10.01 to 20.0 ng/ml and more than 20.0 ng/ml were 88%, 70% and 17%, respectively (pHIFU therapy appears to be a safe and efficacious minimally invasive therapy for patients with localized prostate cancer, especially those with a pretreatment PSA level less than 20 ng/ml.

  19. Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

    The objective was to evaluate T2-weighted (T2w) and dynamic contrast-enhanced (DCE) MRI in detecting local cancer recurrences after prostate high-intensity focused ultrasound (HIFU) ablation. Fifty-nine patients with biochemical recurrence after prostate HIFU ablation underwent T2-weighted and DCE MRI before transrectal biopsy. For each patient, biopsies were performed by two operators: operator 1 (blinded to MR results) performed random and colour Doppler-guided biopsies (''routine biopsies''); operator 2 obtained up to three cores per suspicious lesion on MRI (''targeted biopsies''). Seventy-seven suspicious lesions were detected on DCE images (n=52), T2w images (n=2) or both (n=23). Forty patients and 41 MR lesions were positive at biopsy. Of the 36 remaining MR lesions, 20 contained viable benign glands. Targeted biopsy detected more cancers than routine biopsy (36 versus 27 patients, p=0.0523). The mean percentages of positive cores per patient and of tumour invasion of the cores were significantly higher for targeted biopsies (p<0.0001). The odds ratios of the probability of finding viable cancer and viable prostate tissue (benign or malignant) at targeted versus routine biopsy were respectively 3.35 (95% CI 3.05-3.64) and 1.38 (95% CI 1.13-1.63). MRI combining T2-weighted and DCE images is a promising method for guiding post-HIFU biopsy towards areas containing recurrent cancer and viable prostate tissue. (orig.)

  20. Active noise canceling system for mechanically cooled germanium radiation detectors

    Nelson, Karl Einar; Burks, Morgan T

    2014-04-22

    A microphonics noise cancellation system and method for improving the energy resolution for mechanically cooled high-purity Germanium (HPGe) detector systems. A classical adaptive noise canceling digital processing system using an adaptive predictor is used in an MCA to attenuate the microphonics noise source making the system more deployable.

  1. M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer.

    Xiaoyi Huang

    Full Text Available OBJECTIVE: In this study, we explored the use of mechanical high intensity focused ultrasound (M-HIFU as a neo-adjuvant therapy prior to surgical resection of the primary tumor. We also investigated the role of signal transducer and activator of transcription 3 (STAT3 in M-HIFU elicited anti-tumor immune response using a transplant tumor model of prostate cancer. METHODS: RM-9, a mouse prostate cancer cell line with constitutively activated STAT3, was inoculated subcutaneously in C57BL/6J mice. The tumor-bearing mice (with a maximum tumor diameter of 5∼6 mm were treated by M-HIFU or sham exposure two days before surgical resection of the primary tumor. Following recovery, if no tumor recurrence was observed in 30 days, tumor rechallenge was performed. The growth of the rechallenged tumor, survival rate and anti-tumor immune response of the animal were evaluated. RESULTS: No tumor recurrence and distant metastasis were observed in both treatment groups employing M-HIFU + surgery and surgery alone. However, compared to surgery alone, M-HIFU combined with surgery were found to significantly inhibit the growth of rechallenged tumors, down-regulate intra-tumoral STAT3 activities, increase cytotoxic T cells in spleens and tumor draining lymph nodes (TDLNs, and improve the host survival. Furthermore, M-HIFU combined with surgery was found to significantly decrease the level of immunosuppression with concomitantly increased number and activities of dendritic cells, compared to surgery alone. CONCLUSION: Our results demonstrate that M-HIFU can inhibit STAT3 activities, and when combined synergistically with surgery, may provide a novel and promising strategy for the treatment of prostate cancers.

  2. Prostate cancer multimodal therapy involvement in couple life: Open, Robotic and HIFU approach

    Elisabeta Ioana Hirişcău

    2010-12-01

    Full Text Available The diagnosis and treatment of prostate cancer often results in significant physical side-effectsand associated psycho-social stressors that can interfere with the experience of sexual intimacy forcouples. Our study aims to evaluate couple’s sexual life and to determine any potential sexual dynamicdysfunctions which could occur before and after performing classic, robotic and HIFU radicalprostatectomy as a radical therapy in prostate cancer. The present article aims at the synopticpresentation of results of a statistic research done by the author regarding the factors that influencecouple’s sex life, and also at the identification of potential dynamic disorder that could come up before aradical prostatectomy (disorders that influence the sexual prognostic following the intervention. Materialand method: the research involved 28 couples (56 individuals and was conducted in The Municipal Clinicand in The Endoplus Clinic in Cluj-Napoca. The initial evaluation aimed to identify sexual dynamicdysfunctions before the intervention. The couples filled in an interview sheet before the intervention andwere informed about the immediate and long term effects of the intervention and of existing therapeuticsolutions. The confidentiality of interview answers has been insured and the interviews have beencollected and sealed the day of the intervention. The structure of the interview is based on the BASIC IDgrid proposed by Lazarus in 1973 which aims to establish a therapeutic action profile which would allow amultimodal intervention. All patients underwent the prostate cancer intervention as follows: 10 patientsunderwent open surgery, 9 patients robotic surgery and 9 patients HIFU therapy. Results: Each partnerof the couple was reevaluated two months after the radical therapy. The main goal of evaluating thesexual behavior was to obtain valid information in order to make the optimal therapeutic decision. Thepartner’s answer frequency for both pre and

  3. A framework for the correction of slow physiological drifts during MR-guided HIFU therapies: Proof of concept

    Zachiu, Cornel, E-mail: C.Zachiu@umcutrecht.nl; Moonen, Chrit; Ries, Mario [Imaging Division, UMC Utrecht, Heidelberglaan 100, Utrecht 3584 CX (Netherlands); Denis de Senneville, Baudouin [Imaging Division, UMC Utrecht, Heidelberglaan 100, Utrecht 3584 CX (Netherlands); Mathematical Institute of Bordeaux, University of Bordeaux, Talence Cedex 33405 (France)

    2015-07-15

    Purpose: While respiratory motion compensation for magnetic resonance (MR)-guided high intensity focused ultrasound (HIFU) interventions has been extensively studied, the influence of slow physiological motion due to, for example, peristaltic activity, has so far been largely neglected. During lengthy interventions, the magnitude of the latter can exceed acceptable therapeutic margins. The goal of the present study is to exploit the episodic workflow of these therapies to implement a motion correction strategy for slow varying drifts of the target area and organs at risk over the entire duration of the intervention. Methods: The therapeutic workflow of a MR-guided HIFU intervention is in practice often episodic: Bursts of energy delivery are interleaved with periods of inactivity, allowing the effects of the beam on healthy tissues to recede and/or during which the plan of the intervention is reoptimized. These periods usually last for at least several minutes. It is at this time scale that organ drifts due to slow physiological motion become significant. In order to capture these drifts, the authors propose the integration of 3D MR scans in the therapy workflow during the inactivity intervals. Displacements were estimated using an optical flow algorithm applied on the 3D acquired images. A preliminary study was conducted on ten healthy volunteers. For each volunteer, 3D MR images of the abdomen were acquired at regular intervals of 10 min over a total duration of 80 min. Motion analysis was restricted to the liver and kidneys. For validating the compatibility of the proposed motion correction strategy with the workflow of a MR-guided HIFU therapy, an in vivo experiment on a porcine liver was conducted. A volumetric HIFU ablation was completed over a time span of 2 h. A 3D image was acquired before the first sonication, as well as after each sonication. Results: Following the volunteer study, drifts larger than 8 mm for the liver and 5 mm for the kidneys prove that

  4. A framework for the correction of slow physiological drifts during MR-guided HIFU therapies: Proof of concept

    Purpose: While respiratory motion compensation for magnetic resonance (MR)-guided high intensity focused ultrasound (HIFU) interventions has been extensively studied, the influence of slow physiological motion due to, for example, peristaltic activity, has so far been largely neglected. During lengthy interventions, the magnitude of the latter can exceed acceptable therapeutic margins. The goal of the present study is to exploit the episodic workflow of these therapies to implement a motion correction strategy for slow varying drifts of the target area and organs at risk over the entire duration of the intervention. Methods: The therapeutic workflow of a MR-guided HIFU intervention is in practice often episodic: Bursts of energy delivery are interleaved with periods of inactivity, allowing the effects of the beam on healthy tissues to recede and/or during which the plan of the intervention is reoptimized. These periods usually last for at least several minutes. It is at this time scale that organ drifts due to slow physiological motion become significant. In order to capture these drifts, the authors propose the integration of 3D MR scans in the therapy workflow during the inactivity intervals. Displacements were estimated using an optical flow algorithm applied on the 3D acquired images. A preliminary study was conducted on ten healthy volunteers. For each volunteer, 3D MR images of the abdomen were acquired at regular intervals of 10 min over a total duration of 80 min. Motion analysis was restricted to the liver and kidneys. For validating the compatibility of the proposed motion correction strategy with the workflow of a MR-guided HIFU therapy, an in vivo experiment on a porcine liver was conducted. A volumetric HIFU ablation was completed over a time span of 2 h. A 3D image was acquired before the first sonication, as well as after each sonication. Results: Following the volunteer study, drifts larger than 8 mm for the liver and 5 mm for the kidneys prove that

  5. Noise Residual Learning for Noise Modeling in Distributed Video Coding

    Luong, Huynh Van; Forchhammer, Søren

    2012-01-01

    Distributed video coding (DVC) is a coding paradigm which exploits the source statistics at the decoder side to reduce the complexity at the encoder. The noise model is one of the inherently difficult challenges in DVC. This paper considers Transform Domain Wyner-Ziv (TDWZ) coding and proposes...... noise residual learning techniques that take residues from previously decoded frames into account to estimate the decoding residue more precisely. Moreover, the techniques calculate a number of candidate noise residual distributions within a frame to adaptively optimize the soft side information during...

  6. Active Noise Control for Vehicle Exhaust Noise Reduction

    李克强; 杨殿阁; 郑四发; 连小珉; 田中丈晴

    2003-01-01

    An active noise control (ANC) method was developed for exhaust noise reduction for medium-duty diesel trucks. A modified variable step size least mean squares (LMS) algorithm was used for the controller in a variable environment that considered the vehicle's acceleration characteristics. The variable step size time-based synchronized filtered-x LMS method (SFX-TB) used an adaptive algorithm that was more efficient than the conventional filtered-x LMS algorithm. The simulation and the experimental tests show that the control trackability and stability provided by the algorithm during acceleration enable the ANC system to effectively reduce the vehicle exhaust noise.

  7. Chasing Noise

    Mendel, Brock; Shleifer, Andrei

    2012-01-01

    We present a simple model in which rational but uninformed traders occasionally chase noise as if it were information, thereby amplifying sentiment shocks and moving prices away from fundamental values. We fill a theoretical gap in the literature by showing conditions under which noise traders can have an impact on market equilibrium disproportionate to their size in the market. The model offers a partial explanation for the surprisingly low market price of financial risk in the Spring of 2007.

  8. Crackling Noise

    Sethna, James P.; Dahmen, Karin A.; Christopher R Myers

    2001-01-01

    Crackling noise arises when a system responds to changing external conditions through discrete, impulsive events spanning a broad range of sizes. A wide variety of physical systems exhibiting crackling noise have been studied, from earthquakes on faults to paper crumpling. Because these systems exhibit regular behavior over many decades of sizes, their behavior is likely independent of microscopic and macroscopic details, and progress can be made by the use of very simple models. The fact tha...

  9. Noise Bubbles

    Mario Forni; Luca Gambetti; Marco Lippi; Luca Sala

    2014-01-01

    We introduce noisy information into a standard present value stock price model. Agents receive a noisy signal about the structural shock driving future dividend variations. The resulting equilibrium stock price includes a transitory component — the "noise bubble" — which can be responsible for boom and bust episodes unrelated to economic fundamentals. We propose a non-standard VAR procedure to estimate the structural shock and the "noise" shock, their impulse response functions and the bubble...

  10. Increasing the HIFU ablation rate through an MRI-guided sonication strategy using shock waves: feasibility in the in vivo porcine liver

    Ramaekers, P.; de Greef, M.; van Breugel, J. M. M.; Moonen, C. T. W.; Ries, M.

    2016-02-01

    This study investigated whether an MR-guided pulsed HIFU ablation strategy could be implemented under clinical conditions, using a transducer designed for uterine fibroid ablation, to obtain an ablation rate that is sufficiently high for clinical abdominal HIFU therapy in highly perfused organs. A pulsed HIFU ablation strategy, aimed at increasing the energy absorption in the HIFU focal area by local shock wave formation in the non-linear pressure regime, was compared to an energy-equivalent continuous wave sonication strategy in the linear pressure regime. Both ablation strategies were used for transcutaneous sonication of pre-defined treatment cells in the livers of 5 pigs in vivo. Temperature evolution in both the target area as well as the pre-focal muscle layer was monitored simultaneously using MR thermometry. Local energy absorption and thermal dose volumes were shown to be increased using the pulsed ablation strategy, while preserving healthy tissue in the near field of the acoustic beam. Respiratory motion compensation of both acoustic energy delivery and MR thermometry was applied through gating based on MR navigator echoes. Histopathology showed that confluent vacuolated thermal lesions were created when the pulsed ablation strategy was used. Additionally, it was shown that the heat sink effect caused by the presence of larger vessels could be overcome. The pulsed HIFU ablation strategy achieved an ablation rate of approximately 4 ml per hour in the in vivo porcine liver, without causing undesired damage to healthy tissues in the near field.

  11. Validation of tissue change monitoring (TCM) on the Sonablate® 500 during high intensity focused ultrasound (HIFU) treatment of prostate cancer with real-time thermometry

    Chen, Wo-Hsing; Sanghvi, Narendra T.; Carlson, Roy; Schatzl, Georg; Marberger, Michael

    2012-10-01

    The Sonablate® 500 has quantitative, real-time Tissue Change Monitoring (TCM) software that estimates changes in tissue properties due to HIFU treatment of prostate cancer. This study validates the Sonablate 500 TCM system using real-time thermometry. Five patients with histologically confirmed, organ-confined prostate cancer were enrolled. Four patients with focal cancer had hemiablation and one had whole gland ablation. TCM generates energy reading based on spectral analysis on the RF backscattered ultrasound signals; results are used as an estimator of tissue temperature. Needle thermocouples were placed transperineally under TRUS guidance in the prostate to monitor temperatures from focal zone, posterior to the focal zone and on the lateral gland where no HIFU was applied. The HIFU treatments averaged 37, 35 and 19.7 Watts for the treatment for anterior, middle and posterior zones. The measured temperatures (Average, Max, and Min) in the HIFU treatment zones were 84, 114 and 70 degrees C. The temperature estimated by TCM energy readings were 83% 75-100 degrees C and 17% 60-75 degrees C with an average of 91 degrees C. Outside the focal zone, average recorded temperature was 50 degrees C. Average temperature in the lateral lobe where no HIFU was applied was 40.7 degrees C.

  12. The safety and feasibility of extracorporeal high-intensity focused ultrasound (HIFU) for the treatment of liver and kidney tumours in a Western population.

    Illing, R O; Kennedy, J E; Wu, F; ter Haar, G R; Protheroe, A S; Friend, P J; Gleeson, F V; Cranston, D W; Phillips, R R; Middleton, M R

    2005-10-17

    High-intensity focused ultrasound (HIFU) provides a potential noninvasive alternative to conventional therapies. We report our preliminary experience from clinical trials designed to evaluate the safety and feasibility of a novel, extracorporeal HIFU device for the treatment of liver and kidney tumours in a Western population. The extracorporeal, ultrasound-guided Model-JC Tumor Therapy System (HAIFU Technology Company, China) has been used to treat 30 patients according to four trial protocols. Patients with hepatic or renal tumours underwent a single therapeutic HIFU session under general anaesthesia. Magnetic resonance imaging 12 days after treatment provided assessment of response. The patients were subdivided into those followed up with further imaging alone or those undergoing surgical resection of their tumours, which enabled both radiological and histological assessment. HIFU exposure resulted in discrete zones of ablation in 25 of 27 evaluable patients (93%). Ablation of liver tumours was achieved more consistently than for kidney tumours (100 vs 67%, assessed radiologically). The adverse event profile was favourable when compared to more invasive techniques. HIFU treatment of liver and kidney tumours in a Western population is both safe and feasible. These findings have significant implications for future noninvasive image-guided tumour ablation. PMID:16189519

  13. Gas-filled phospholipid nanoparticles conjugated with gadolinium play a role as a potential theragnostics for MR-guided HIFU ablation.

    Se-Young Choi

    Full Text Available To develop a long-circulating theragnostics, meaning therapeutics and diagnostics for MR-guided HIFU ablation, we designed and prepared Gd-C(5F(12-phospholipid nanobubbles (PLNs 30-100 nm in diameter. The biochemical and physical characterization of Gd-C(5F(12-PLNs were performed. Since Gd-C(5F(12-PLN-50 (Φ = 50 nm and Gd-C(5F(12-PLN-100 (Φ = 100 nm enhanced the hyperthermal effect of HIFU size- and concentration-dependently in a tissue-mimicking phantom, its circulation, distribution, tumor accumulation and tumor ablation were examined in tumor-bearing mice. The plasma-half life of Gd-C(5F(12-PLNs was longer than 1.5 hrs. Gd-C(5F(12-PLNs mainly accumulated in the liver and the spleen, suggesting that they are slowly secreted through the hepatobiliary pathway. Monitored by the T1 signal intensity of MR, Gd-C(5F(12-PLNs accumulated in tumor tissues for 8 hours in mice. HIFU with Gd-C(5F(12-PLN-100 showed the increased tumor ablation area as compared with HIFU alone. The results suggest that Gd-C(5F(12-PLNs exhibit a potential theragnostics for MR-guided HIFU ablation.

  14. HIFU procedures at moderate intensities-effect of large blood vessels

    A three-dimensional computational model is presented for studying the efficacy of high-intensity focused ultrasound (HIFU) procedures targeted near large blood vessels. The analysis applies to procedures performed at intensities below the threshold for cavitation, boiling and highly nonlinear propagation, but high enough to increase tissue temperature a few degrees per second. The model is based upon the linearized KZK equation and the bioheat equation in tissue. In the blood vessel the momentum and energy equations are satisfied. The model is first validated in a tissue phantom, to verify the absence of bubble formation and nonlinear effects. Temperature rise and lesion-volume calculations are then shown for different beam locations and orientations relative to a large vessel. Both single and multiple ablations are considered. Results show that when the vessel is located within about a beam width (few mm) of the ultrasound beam, significant reduction in lesion volume is observed due to blood flow. However, for gaps larger than a beam width, blood flow has no major effect on the lesion formation. Under the clinically representative conditions considered, the lesion volume is reduced about 40% (relative to the no-flow case) when the beam is parallel to the blood vessel, compared to about 20% for a perpendicular orientation. Procedures involving multiple ablation sites are affected less by blood flow than single ablations. The model also suggests that optimally focused transducers can generate lesions that are significantly larger (>2 times) than the ones produced by highly focused beams

  15. Calibration of HIFU intensity fields measured using an infra-red camera

    Shaw, A [Acoustics and Ionising Radiation Division, National Physical Laboratory, Teddington TW11 0LW (United Kingdom); Khokhlova, V; Bobkova, S [Department of Acoustics, Physics Faculty, Moscow State University, Moscow 119991 (Russian Federation); Gavrilov, L [N.N. Andreev Acoustics Institute, 117036 Moscow (Russian Federation); Hand, J, E-mail: vera@acs366.phys.msu.ru [Imaging Sciences Department, Imperial College London (Hammersmith Hospital Campus), London W12 0NN (United Kingdom)

    2011-02-01

    A trend in HIFU technologies is to use 2D phased arrays that offer electronic steering of a single focus and formation of patterns of multiple foci. Conventional methods to characterize array fields using scanned hydrophone would be prohibitively slow given the potentially large number of focusing conditions. An alternative technique for rapid qualitative assessment of intensity distributions was recently developed. The method is based on infrared camera measurements of the temperature rises induced by low amplitude short ultrasonic bursts in a thin absorber. Here, the method is extended to estimate the absolute values of intensity in a field of a 2D 1-MHz randomized phased array. Two approaches were implemented. In the first approach it was assumed that the measured temperature rise at the surface of the absorber is proportional to the free field intensity. The second approach correlated the temperature rise measured in an absorber and calculated from the modelled acoustic field and the heat transfer equation. Corresponding correction factors between the free field intensity and temperature was obtained and introduced in the conversion of temperature images to intensity. Free field distributions in water and focusing through ribs were recorded and simulated. Good correlation between the measured and modeled results in both spatial distributions and the absolute values of intensity was demonstrated.

  16. HIFU procedures at moderate intensities-effect of large blood vessels

    Hariharan, P [Mechanical, Industrial, and Nuclear Engineering Department, University of Cincinnati, Cincinnati, OH (United States); Myers, M R [Division of Solid and Fluid Mechanics, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Avenue, Building 62, Silver Spring, MD 20993-0002 (United States); Banerjee, R K [Mechanical, Industrial, and Nuclear Engineering Department, University of Cincinnati, Cincinnati, OH (United States)

    2007-07-21

    A three-dimensional computational model is presented for studying the efficacy of high-intensity focused ultrasound (HIFU) procedures targeted near large blood vessels. The analysis applies to procedures performed at intensities below the threshold for cavitation, boiling and highly nonlinear propagation, but high enough to increase tissue temperature a few degrees per second. The model is based upon the linearized KZK equation and the bioheat equation in tissue. In the blood vessel the momentum and energy equations are satisfied. The model is first validated in a tissue phantom, to verify the absence of bubble formation and nonlinear effects. Temperature rise and lesion-volume calculations are then shown for different beam locations and orientations relative to a large vessel. Both single and multiple ablations are considered. Results show that when the vessel is located within about a beam width (few mm) of the ultrasound beam, significant reduction in lesion volume is observed due to blood flow. However, for gaps larger than a beam width, blood flow has no major effect on the lesion formation. Under the clinically representative conditions considered, the lesion volume is reduced about 40% (relative to the no-flow case) when the beam is parallel to the blood vessel, compared to about 20% for a perpendicular orientation. Procedures involving multiple ablation sites are affected less by blood flow than single ablations. The model also suggests that optimally focused transducers can generate lesions that are significantly larger (>2 times) than the ones produced by highly focused beams.

  17. EXPERIENCE WITH A HISTOSCANNING APPARATUS USED IN THE DIAGNOSIS OF RECURRENT PROSTATE CANCER AFTER HIFU ABLATION

    P. V. Glybochko

    2012-01-01

    Full Text Available The new potentialities of 3D transrectal ultrasound study were realized in a HistoScanning diagnostic unit. It has been used at the R.M. Fronshtein Urology Clinic, Research Institute of Uronephrology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, since September 2011. A study of the sensitivity and specificity of the technique enrolled patients undergoing high-intensity focused ultrasound (HIFU ablation of the prostate of for its (PC in the period 1 to 7 years. Prostate biopsy study with subsequent histology was made to confirm the results of histoscanning. Statistical processing of the obtained data showed that the sensitivity and specificity of histoscanning were 96 −100 and 87.5 −100%, respectively. These results allow one to appreciate histoscanning as a highly sensitive technique that advantageously differs in its significance level and informative value from now routinely used methods. The study on the possibility of planning and monitoring patients after focal treatments for PC opens up great prospects in achieving a balance between the radicality of performed surgery and the maintenance of quality of life in patients.

  18. EXPERIENCE WITH A HISTOSCANNING APPARATUS USED IN THE DIAGNOSIS OF RECURRENT PROSTATE CANCER AFTER HIFU ABLATION

    P. V. Glybochko

    2014-08-01

    Full Text Available The new potentialities of 3D transrectal ultrasound study were realized in a HistoScanning diagnostic unit. It has been used at the R.M. Fronshtein Urology Clinic, Research Institute of Uronephrology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, since September 2011. A study of the sensitivity and specificity of the technique enrolled patients undergoing high-intensity focused ultrasound (HIFU ablation of the prostate of for its (PC in the period 1 to 7 years. Prostate biopsy study with subsequent histology was made to confirm the results of histoscanning. Statistical processing of the obtained data showed that the sensitivity and specificity of histoscanning were 96 −100 and 87.5 −100%, respectively. These results allow one to appreciate histoscanning as a highly sensitive technique that advantageously differs in its significance level and informative value from now routinely used methods. The study on the possibility of planning and monitoring patients after focal treatments for PC opens up great prospects in achieving a balance between the radicality of performed surgery and the maintenance of quality of life in patients.

  19. High intensity focused ultrasound (HIFU) for treatment of T1/T2 prostate cancer

    Sanghvi, N.; Gardner, T.; Koch, M.

    2003-04-01

    This FDA approved phase I/II clinical trial is to evaluate the safety and efficacy of the Sonablate device (Focus Surgery, Inc.) for the treatment of organ confined prostate cancer. 20 patients with biopsy proven prostate cancer, Gleason Prostate Symptom Score, International Impotence and Erectile Function score, and the SF-36 health survey. The mean patient age is 62.0, Gleason score of 6.18, PSA of 5.2, and prostate size 26.0 gm. Mean PSA results were 5.62, 44, 20, 1.68, 0.87, and 0.44 ng/ml at screening, 48-72 hours, 14 days, 30 days, 90 days and 180 days, respectively. There was one patient (9%) with a positive TRUS biopsy at 6 months, which resulted in a retreatment. There were no rectal injuries. Average pre-treatment IPSS, IIEF, and SF-36 scores were 9.55, 16.1, and 103.5. At the 30 day follow-up, they were 18.3, 3, and 97.4, respectively. HIFU is a minimally invasive modality that achieves complete prostatic ablation and is efficacious in the treatment of low-stage prostate cancer.

  20. Calibration of HIFU intensity fields measured using an infra-red camera

    A trend in HIFU technologies is to use 2D phased arrays that offer electronic steering of a single focus and formation of patterns of multiple foci. Conventional methods to characterize array fields using scanned hydrophone would be prohibitively slow given the potentially large number of focusing conditions. An alternative technique for rapid qualitative assessment of intensity distributions was recently developed. The method is based on infrared camera measurements of the temperature rises induced by low amplitude short ultrasonic bursts in a thin absorber. Here, the method is extended to estimate the absolute values of intensity in a field of a 2D 1-MHz randomized phased array. Two approaches were implemented. In the first approach it was assumed that the measured temperature rise at the surface of the absorber is proportional to the free field intensity. The second approach correlated the temperature rise measured in an absorber and calculated from the modelled acoustic field and the heat transfer equation. Corresponding correction factors between the free field intensity and temperature was obtained and introduced in the conversion of temperature images to intensity. Free field distributions in water and focusing through ribs were recorded and simulated. Good correlation between the measured and modeled results in both spatial distributions and the absolute values of intensity was demonstrated.

  1. HIFU procedures at moderate intensities--effect of large blood vessels.

    Hariharan, P; Myers, M R; Banerjee, R K

    2007-06-21

    A three-dimensional computational model is presented for studying the efficacy of high-intensity focused ultrasound (HIFU) procedures targeted near large blood vessels. The analysis applies to procedures performed at intensities below the threshold for cavitation, boiling and highly nonlinear propagation, but high enough to increase tissue temperature a few degrees per second. The model is based upon the linearized KZK equation and the bioheat equation in tissue. In the blood vessel the momentum and energy equations are satisfied. The model is first validated in a tissue phantom, to verify the absence of bubble formation and nonlinear effects. Temperature rise and lesion-volume calculations are then shown for different beam locations and orientations relative to a large vessel. Both single and multiple ablations are considered. Results show that when the vessel is located within about a beam width (few mm) of the ultrasound beam, significant reduction in lesion volume is observed due to blood flow. However, for gaps larger than a beam width, blood flow has no major effect on the lesion formation. Under the clinically representative conditions considered, the lesion volume is reduced about 40% (relative to the no-flow case) when the beam is parallel to the blood vessel, compared to about 20% for a perpendicular orientation. Procedures involving multiple ablation sites are affected less by blood flow than single ablations. The model also suggests that optimally focused transducers can generate lesions that are significantly larger (>2 times) than the ones produced by highly focused beams. PMID:17664556

  2. Cardiorespiratory Responses to Acoustic Noise in Belugas.

    Lyamin, Oleg I; Korneva, Svetlana M; Rozhnov, Viatcheslav V; Mukhametov, Lev M

    2016-01-01

    To date, most research on the adverse effects of anthropogenic noise on marine mammals has focused on auditory and behavioral responses. Other responses have received little attention and are often ignored. In this study, the effect of acoustic noise on heart rate was examined in captive belugas. The data suggest that (1) heart rate can be used as a measure of physiological response (including stress) to noise in belugas and other cetaceans, (2) cardiac response is influenced by parameters of noise and adaptation to repeated exposure, and (3) cetacean calves are more vulnerable to the adverse effect of noise than adults. PMID:26611017

  3. A Study of Speckle Noise Reduction Filters

    Jyoti Jaybhay

    2015-06-01

    Full Text Available Ultrasound images and SAR i.e. synthetic aperture radar images are usually corrupted because of speckle noise also called as granular noise. It is quite a tedious task to remove such noise and analyze those corrupted images. Till now many researchers worked to remove speckle noise using frequency domain methods, temporal methods, and adaptive methods. Different filters have been developed as Mean and Median filters, Statistic Lee filter, Statistic Kuan filter, Frost filter, Srad filter. This paper reviews filters used to remove speckle noise.

  4. Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

    Rouviere, Olivier; Lyonnet, Denis [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Lyon (France); Universite de Lyon, Lyon (France); Universite de Lyon 1, Faculte de medecine Lyon Nord, Lyon (France); Inserm, U556, Lyon (France); Girouin, Nicolas; Glas, Ludivine; Ben Cheikh, Alexandre [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Lyon (France); Universite de Lyon, Lyon (France); Universite de Lyon 1, Faculte de medecine Lyon Nord, Lyon (France); Gelet, Albert [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Urology, Lyon (France); Inserm, U556, Lyon (France); Mege-Lechevallier, Florence [Hopital Edouard Herriot, Hospices Civils de Lyon, Department of Pathology, Lyon (France); Rabilloud, Muriel [Hospices Civils de Lyon, Department of Biostatistics, Lyon (France); Universite de Lyon 1, UMR CNRS, Laboratoire Biostatistiques-Sante, Pierre-Benite (France); Chapelon, Jean-Yves [Inserm, U556, Lyon (France)

    2010-01-15

    The objective was to evaluate T2-weighted (T2w) and dynamic contrast-enhanced (DCE) MRI in detecting local cancer recurrences after prostate high-intensity focused ultrasound (HIFU) ablation. Fifty-nine patients with biochemical recurrence after prostate HIFU ablation underwent T2-weighted and DCE MRI before transrectal biopsy. For each patient, biopsies were performed by two operators: operator 1 (blinded to MR results) performed random and colour Doppler-guided biopsies (''routine biopsies''); operator 2 obtained up to three cores per suspicious lesion on MRI (''targeted biopsies''). Seventy-seven suspicious lesions were detected on DCE images (n=52), T2w images (n=2) or both (n=23). Forty patients and 41 MR lesions were positive at biopsy. Of the 36 remaining MR lesions, 20 contained viable benign glands. Targeted biopsy detected more cancers than routine biopsy (36 versus 27 patients, p=0.0523). The mean percentages of positive cores per patient and of tumour invasion of the cores were significantly higher for targeted biopsies (p<0.0001). The odds ratios of the probability of finding viable cancer and viable prostate tissue (benign or malignant) at targeted versus routine biopsy were respectively 3.35 (95% CI 3.05-3.64) and 1.38 (95% CI 1.13-1.63). MRI combining T2-weighted and DCE images is a promising method for guiding post-HIFU biopsy towards areas containing recurrent cancer and viable prostate tissue. (orig.)

  5. Postoperative monitoring of prostate-specific antigen (PSA after treatment with high-intensive focused ultrasound (HIFU

    Blyumberg B.I.

    2012-12-01

    Full Text Available Research objective: to estimate efficiency of treatment of prostate cancer using high-intensive focused ultrasound on the basis of laboratory analysis of postoperative level prostate-specific antigen (PSA. Objects of research. Objects of research consisted of 110 patients treated in urological clinic of Hospital n.a. S. R. Mirotvortsev (Saratov State Medical University during the period February, 2009 — March, 2012. Patients took 110 sessions of primary operative treatment of prostate cancer by HIFU therapy method. Technique and research methods. Concentration of PSA in blood changed in all patients every 1,5 month within 6 months after operation, irrespective of its kind (including after repeated HIFU, further — after every 3 month till one year, and later on after 6 months. We were guided by references of the International Consensus, which considers PSA level more than 0,5 ng/ml in blood after 3 months of treatment to be unsatisfactory result. We also headed for PSA level before treatment and oncological risk degree. Results. Median nadir formed 0,5 ng/ml PSA by 3 months after treatment. Patients demonstrated different indicators of PSA dynamics depending on oncological risk, stage and hormonal therapy management. Patients with low oncological risk had initially lower PSA concentration, further PSA concentration reached nadir level faster. At patients with widespread forms of prostate cancer accurate dependence of PSA concentration according to prevalence of process was traced. Time of PSA nadir amount did not differ and was marked as 12-14 weeks on average. At patients received hormonal therapy, lower value of PSA nadir was marked. The conclusion. Monitoring of PSA concentration (PSA nadir by 3 months, dynamics of PSA concentration change is of great importance in early revealing of relapse after prostate HIFU therapy. High level of PSA nadir and PSA growth according to time period are important prognostic factors.

  6. M-HIFU Inhibits Tumor Growth, Suppresses STAT3 Activity and Enhances Tumor Specific Immunity in a Transplant Tumor Model of Prostate Cancer

    Xiaoyi Huang; Fang Yuan; Meihua Liang; Hui-Wen Lo; Shinohara, Mari L.; Cary Robertson; Pei Zhong

    2012-01-01

    OBJECTIVE: In this study, we explored the use of mechanical high intensity focused ultrasound (M-HIFU) as a neo-adjuvant therapy prior to surgical resection of the primary tumor. We also investigated the role of signal transducer and activator of transcription 3 (STAT3) in M-HIFU elicited anti-tumor immune response using a transplant tumor model of prostate cancer. METHODS: RM-9, a mouse prostate cancer cell line with constitutively activated STAT3, was inoculated subcutaneously in C57BL/6J m...

  7. Preparation of HIFU-triggered tumor-targeted hyaluronic acid micelles for controlled drug release and enhanced cellular uptake.

    Zheng, Shaohui; Jin, Zhen; Han, Jiwon; Cho, Sunghoon; Nguyen, Van Du; Ko, Seong Young; Park, Jong-Oh; Park, Sukho

    2016-07-01

    In this study, a novel type of high intensity focused ultrasound (HIFU)-triggered active tumor-targeting polymeric micelle was prepared and investigated for controlled drug release and enhanced cellular uptake. Amphiphilic hyaluronic acid (HA) conjugates were synthesized to form docetaxel loaded micelles in aqueous conditions with high encapsulation efficiencies of over 80%. The micelle sizes were limited to less than 150nm, and they varied slightly according to the encapsulated drug amount. Modifying the micellar surface modification with polyethylene glycol diamine successfully inhibited premature drug leakage at a certain level, and it can be expected to prolong the circulation time of the particles in blood. In addition, high-intensity focused ultrasound was introduced to control the release of docetaxel from micelles, to which the release behavior of a drug can be tuned. The in-vitro cell cytotoxicity of docetaxel-loaded micelles was verified against CT-26 and MDA-MB-231 cells. The IC50 values of drug-loaded micelles to CT-26 and MDA-MB-231 cells were 1230.2 and 870.9ng/mL, respectively. However, when exposed to HIFU, the values decreased significantly, to 181.9 and 114.3ng/mL, suggesting that HIFU can enhance cell cytotoxicity by triggering the release of a drug from the micelles. Furthermore, cellular uptake tests were conducted via the quantitative analysis of intracellular drug concentration within CT-26 (CD44 negative), MDA-MB-231 (CD44 positive), and MDA-MB-231 (CD44 blocked), and then imaged with coumarin-6 loaded micelles. The results verified that intracellular drug delivery can be enhanced efficiently via the CD44 receptor-mediated endocytosis of HA micelles. Moreover, HIFU enhanced the cellular uptake behavior by altering the permeability of the cell membrane. It was also able to aid with the extravasation of micelles into the interior of tumors, which will be explained in further research. Therefore, the present study demonstrates that the micelles

  8. 基于EMD和ANFIS的自适应噪声消除研究%STUDY ON AN ADAPTIVE NOISE CANCELLATION BASED ON EMD (EMPIRICAL MODE DECOMPOSITION) AND ANFIS (ADAPTIVE NEURO-FUZZY INFERENCE SYSTEM)

    徐春生; 王太勇

    2009-01-01

    对于混入色噪声的混合信号,如果可以通过测量得到产生色噪声的白噪声,对白噪声进行非线性训练即可逼近色噪声,达到非线性滤波的目的.自适应模糊推理系统(adaptive neuro-fuzzy unference system,ANFIS)可以实现上述非线性逼近.文中在上述算法的基础上,提出一种EMD(empirical mode decomposition)-ANFIS的自适应色噪声消除方法,首先对混合信号进行EMD分解,得到各个内禀模态函数分量(intrinsic mode function, IMF),然后对分解得到的内禀模态分量进行ANFIS模糊消噪,最后对消噪后的各个分量信号进行叠加.由于所得内禀模态函数为近似平稳信号,且图形越来越趋于平缓,减小了ANFIS方法的逼近难度.在混合信号信噪比为2.840 7 dB时,经过EMD-ANFIS消噪后的估计误差比只经过ANFIS消噪后的估计误差减少11.74 dB,证明EMD-ANFIS方法的有效性.

  9. Improving Gabor Noise

    Lagae, Ares; Lefebvre, Sylvain; Dutré, Philip

    2011-01-01

    We have recently proposed a new procedural noise function, Gabor noise, which offers a combination of properties not found in existing noise functions. In this paper, we present three significant improvements to Gabor noise: (1) an isotropic kernel for Gabor noise, which speeds up isotropic Gabor noise with a factor of roughly two, (2) an error analysis of Gabor noise, which relates the kernel truncation radius to the relative error of the noise, and (3) spatially varying Gabor noise, which e...

  10. Temperature-modulated fluorescence tomography: modulating tissue temperature using HIFU for high-resolution in vivo fluorescence tomography

    Kwong, Tiffany C.; Nouizi, Farouk; Lin, Yuting; Sampathkumaran, Uma; Ahmed, Shaaz; Gulsen, Gultekin

    2013-03-01

    Low spatial resolution due to strong tissue scattering is one of the main barriers that prevent the wide-spread use of fluorescence tomography. To overcome this limitation, we previously demonstrated a new technique, temperature modulated fluorescence tomography (TM-FT), which relies on key elements: temperature sensitive ICG loaded pluronic nanocapsules and high intensity focused ultrasound (HIFU), to combine the sensitivity of fluorescence imaging with focused ultrasound resolution. While conventional fluorescence tomography measurements are acquired, the tissue is scanned by a HIFU beam and irradiated to produce a local hot spot, in which the temperature increases nearly 5K. The fluorescence emission signal measured by the optical detectors varies drastically when the hot spot overlays onto the location of the temperature dependent nanocapsules. The small size of the focal spot (~1.4 mm) up to a depth of 6 cm, allows imaging the distribution of these temperature sensitive agents with not only high spatial resolution but also high quantitative accuracy in deep tissue using a proper image reconstruction algorithm. Previously we have demonstrated this technique with a phantom study with nanocapsules sensitive to 20-25°C range. In this work, we will show the first nanocapsules optimized for in vivo animal imaging.

  11. Registration of CT to pre-treatment MRI for planning of MR-HIFU ablation treatment of painful bone metastases

    MR-HIFU is a new non-invasive treatment modality that can be used for palliation in patients with painful bone metastases. Since treatment strategies are mainly focused on the ablation of periosteal nerves, information on the presence and geometry of cortical bone influences the treatment strategy, both in determining the acoustic power and in avoiding safety issues related to far-field heating. Although MRI is available for imaging during treatment, CT is best used for examining the cortical bone. We present a registration method for registering CT and MR images of patients with bone metastases prior to therapy. CT and MRI data were obtained from nine patients with metastatic bone lesions at varying locations. A two-step registration approach was used, performing simultaneous rigid registration of all available MR images in the first step and an affine and deformable registration with an additional bone metric in the second step. The performance was evaluated using landmark annotation by clinical observers. An average registration error of 4.5 mm was obtained, which was comparable to the slice thickness of the data. The performance of the registration algorithm was satisfactory, even with differences in MRI acquisition parameters and for various anatomical sites. The obtained CT overlay is useful for treatment planning, as it allows an assessment of the integrity of the cortical bone. CT-MR registration is therefore recommended for HIFU treatment planning of patients with bone metastases. (paper)

  12. Registration of CT to pre-treatment MRI for planning of MR-HIFU ablation treatment of painful bone metastases

    Noorda, Yolanda H.; Bartels, Lambertus W.; Huisman, Merel; Nijenhuis, Robbert J.; AAJ van den Bosch, Maurice; Pluim, Josien PW

    2014-08-01

    MR-HIFU is a new non-invasive treatment modality that can be used for palliation in patients with painful bone metastases. Since treatment strategies are mainly focused on the ablation of periosteal nerves, information on the presence and geometry of cortical bone influences the treatment strategy, both in determining the acoustic power and in avoiding safety issues related to far-field heating. Although MRI is available for imaging during treatment, CT is best used for examining the cortical bone. We present a registration method for registering CT and MR images of patients with bone metastases prior to therapy. CT and MRI data were obtained from nine patients with metastatic bone lesions at varying locations. A two-step registration approach was used, performing simultaneous rigid registration of all available MR images in the first step and an affine and deformable registration with an additional bone metric in the second step. The performance was evaluated using landmark annotation by clinical observers. An average registration error of 4.5 mm was obtained, which was comparable to the slice thickness of the data. The performance of the registration algorithm was satisfactory, even with differences in MRI acquisition parameters and for various anatomical sites. The obtained CT overlay is useful for treatment planning, as it allows an assessment of the integrity of the cortical bone. CT-MR registration is therefore recommended for HIFU treatment planning of patients with bone metastases.

  13. Relativistic Noise

    Kapusta, Joseph; Mueller, Berndt; Stephanov, Misha

    2012-01-01

    The relativistic theory of hydrodynamic fluctuations, or noise, is derived and applied to high energy heavy ion collisions. These fluctuations are inherent in any space-time varying system and are in addition to initial state fluctuations. We illustrate the effects with the boost-invariant Bjorken solution to the hydrodynamic equations. Long range correlations in rapidity are induced by propagation of sound modes. The magnitude of these correlations are directly proportional to the viscositie...

  14. Skewed Noise

    David Dillenberger; Uzi Segal

    2013-01-01

    Experimental evidence suggests that individuals who face an asymmetric distribution over the likelihood of a specific event might actually prefer not to know the exact value of this probability. We address these findings by studying a decision maker who has recursive, non-expected utility preferences over two-stage lotteries. For a binary lottery that yields the better outcome with probability p, we identify noise around p with a compound lottery that induces a probability distribution over t...

  15. Optimal Height Calculation and Modelling of Noise Barrier

    Raimondas Grubliauskas

    2011-04-01

    Full Text Available Transport is one of the main sources of noise having a particularly strong negative impact on the environment. In the city, one of the best methods to reduce the spread of noise in residential areas is a noise barrier. The article presents noise reduction barrier adaptation with empirical formulas calculating and modelling noise distribution. The simulation of noise dispersion has been performed applying the CadnaA program that allows modelling the noise levels of various developments under changing conditions. Calculation and simulation is obtained by assessing the level of noise reduction using the same variables. The investigation results are presented as noise distribution isolines. The selection of a different height of noise barriers are the results calculated at the heights of 1, 4 and 15 meters. The level of noise reduction at the maximum overlap of data, calculation and simulation has reached about 10%.Article in Lithuanian

  16. Intra-operative ultrasound hand-held strain imaging for the visualization of ablations produced in the liver with a toroidal HIFU transducer: first in vivo results

    Chenot, J; Melodelima, D; N' Djin, W A; Souchon, Remi; Rivoire, M; Chapelon, J Y, E-mail: jeremy.chenot@inserm.f [Inserm, U556, Lyon, F-69003 (France)

    2010-06-07

    The use of hand-held ultrasound strain imaging for the intra-operative real-time visualization of HIFU (high-intensity focused ultrasound) ablations produced in the liver by a toroidal transducer was investigated. A linear 12 MHz ultrasound imaging probe was used to obtain radiofrequency signals. Using a fast cross-correlation algorithm, strain images were calculated and displayed at 60 frames s{sup -1}, allowing the use of hand-held strain imaging intra-operatively. Fourteen HIFU lesions were produced in four pigs. Intra-operative strain imaging of HIFU ablations in the liver was feasible owing to the high frame rate. The correlation between dimensions measured on gross pathology and dimensions measured on B-mode images and on strain images were R = 0.72 and R = 0.94 respectively. The contrast between ablated and non-ablated tissue was significantly higher (p < 0.05) in the strain images (22 dB) than in the B-mode images (9 dB). Strain images allowed equivalent or improved definition of ablated regions when compared with B-mode images. Real-time intra-operative hand-held strain imaging seems to be a promising complement to conventional B-mode imaging for the guidance of HIFU ablations produced in the liver during an open procedure. These results support that hand-held strain imaging outperforms conventional B-mode ultrasound and could potentially be used for the assessment of thermal therapies.

  17. Intra-operative ultrasound hand-held strain imaging for the visualization of ablations produced in the liver with a toroidal HIFU transducer: first in vivo results

    The use of hand-held ultrasound strain imaging for the intra-operative real-time visualization of HIFU (high-intensity focused ultrasound) ablations produced in the liver by a toroidal transducer was investigated. A linear 12 MHz ultrasound imaging probe was used to obtain radiofrequency signals. Using a fast cross-correlation algorithm, strain images were calculated and displayed at 60 frames s-1, allowing the use of hand-held strain imaging intra-operatively. Fourteen HIFU lesions were produced in four pigs. Intra-operative strain imaging of HIFU ablations in the liver was feasible owing to the high frame rate. The correlation between dimensions measured on gross pathology and dimensions measured on B-mode images and on strain images were R = 0.72 and R = 0.94 respectively. The contrast between ablated and non-ablated tissue was significantly higher (p < 0.05) in the strain images (22 dB) than in the B-mode images (9 dB). Strain images allowed equivalent or improved definition of ablated regions when compared with B-mode images. Real-time intra-operative hand-held strain imaging seems to be a promising complement to conventional B-mode imaging for the guidance of HIFU ablations produced in the liver during an open procedure. These results support that hand-held strain imaging outperforms conventional B-mode ultrasound and could potentially be used for the assessment of thermal therapies.

  18. Simultaneous measurement of acoustic pressure and temperature in the HIFU fields using all-silica fiber optic Fabry-Perot hydorophone

    Wang, Dai-Hua; Zeng, Lu-Yu; Jia, Ping-Gang; Liu, Lei; Jiang, Xin-Yin

    2014-11-01

    Accurately measuring the acoustic pressure distributions and the size of the focal regions of high-intensity focused ultrasound (HIFU) fields, as well as the temperature induced by the HIFUs, are significant for ensuring the efficiency and safety of treatments. In our previous work, a tip-sensitive all-silica fiber-optic Fabry-Perot (TAFOFP) ultrasonic hydrophone for measuring HIFU fields is developed. In this paper, we explore the possibility that utilizing the TAFOFP ultrasonic hydrophone to simultaneously measure the acoustic pressure of HIFU fields and the induced temperature. The TAFOFP ultrasonic hydrophone for simultaneously measuring the acoustic pressure and temperature is developed and the experiment setup for measuring the HIFU fields based on the developed TAFOFP ultrasonic hydrophone is established. The developed TAFOFP ultrasonic hydrophone is experimentally tested in the degassed water and tissue phantom to verify the possibility of simultaneously measuring the acoustic pressure and temperature. Experimental results show that the sensing system can simultaneously measure the acoustic pressure and temperature.

  19. Low noise road surfaces

    Bolčina, Matjaž

    2014-01-01

    Noise is everywhere. Noise is a sound that makes people stressful and irritate. It often couses sleep disorders and also health problems like different cardiovascular disorders, hearing loss…In most cases traffic noise is the most disturbing. There are different ways to prevent people from traffic noise like building noise barriers and insulation of facades. However noise barriers and insulation of facades do not prevent noise formation, but are lowering existing noise. Another disadvantage i...

  20. Noise in Optical Amplifiers

    Jeppesen, Palle

    1997-01-01

    Noise in optical amplifiers is discussed on the basis of photons and electromagntic fields. Formulas for quantum noise from spontaneous emission, signal-spontaneous beat noise and spontaneous-spontaneous beat noise are derived.......Noise in optical amplifiers is discussed on the basis of photons and electromagntic fields. Formulas for quantum noise from spontaneous emission, signal-spontaneous beat noise and spontaneous-spontaneous beat noise are derived....

  1. The rise of high intensity focused ultrasound (HIFU) non-invasive therapy for solid tumors%高强聚焦超声(HIFU)无创治疗肿瘤技术的崛起

    冯若; 朱辉; 李发琪; 苏海兵; 陈迅

    2011-01-01

    20世纪40年代,美国学者首次提出了高强聚焦超声治疗技术的概念,并进行了初步的工程和临床研究.70、80年代间,治疗肿瘤的温热疗法曾盛行一时.90年代之后,高强聚焦超声外科肿瘤治疗技术在国际上重新崛起,我国率先推出了大型高强聚焦超声肿瘤治疗系统,并成功地应用于临床治疗乳腺癌、骨肿瘤、肝癌等多种实体肿瘤.迄今,该"JC型高强聚焦超声肿瘤治疗系统"已出口到英国、意大利、西班牙、日本、韩国等许多欧亚国家,在诸如欧洲肿瘤治疗中心等20多个医疗中心运行,治疗肿瘤患者达数万例.我国持续保持着引领世界超声无创治疗技术发展的领先地位.%In the 40 years of last centry American scientists put forward a concep of high intensity focused ultrasound (HIFU) therapeutic technique and had done some technical and clinical studies. Since 90 years the HIFU surgery technique treating tumors anew rised abruptly in the world. China firstly put out a comprehensive HIFU tumor treating sistem and successfully treated many solid tumors such as breast cancer, bone tumor, liver cancer etc.. Now the treating sistem has already exported to England, Italy,Spain, Japan, Colea etc. and treated tens thousands tumor patients. In the field of noninvasive ultrasound treating tumor technique China has continually kept the leading position in the world.

  2. Noise screen for attitude control system

    Rodden, John J. (Inventor); Stevens, Homer D. (Inventor); Hong, David P. (Inventor); Hirschberg, Philip C. (Inventor)

    2002-01-01

    An attitude control system comprising a controller and a noise screen device coupled to the controller. The controller is adapted to control an attitude of a vehicle carrying an actuator system that is adapted to pulse in metered bursts in order to generate a control torque to control the attitude of the vehicle in response to a control pulse. The noise screen device is adapted to generate a noise screen signal in response to the control pulse that is generated when an input attitude error signal exceeds a predetermined deadband attitude level. The noise screen signal comprises a decaying offset signal that when combined with the attitude error input signal results in a net attitude error input signal away from the predetermined deadband level to reduce further control pulse generation.

  3. Ultrasonography-based 2D motion-compensated HIFU sonication integrated with reference-free MR temperature monitoring: a feasibility study ex vivo

    Magnetic resonance imaging (MRI) and ultrasonography have been used simultaneously in this ex vivo study for the image-guidance of high intensity focused ultrasound (HIFU) treatment in moving tissue. A ventilator-driven balloon produced periodic and non-rigid (i.e. breathing-like) motion patterns in phantoms. MR-compatible ultrasound (US) imaging enabled near real-time 2D motion tracking based on optical flow detection, while near-harmonic reference-free proton resonance frequency shift (PRFS) MR thermometry (MRT) was used to monitor the thermal buildup on line. Reference-free MRT was applied to gradient-echo echo-planar imaging phase maps acquired at the frame rate of 250 to 300 ms/slice with voxel size 1.25×1.25×5 mm3. The MR-US simultaneous imaging was completely free of mutual interferences while minor RF interferences from the HIFU device were detected in the far field of the US images. The effective duty-cycle of the HIFU sonication was close to 100 % and no off-interval was required to temporally decouple it from the ultrasonography. The motion compensation of the HIFU sonication was achieved with an 8 Hz frame rate and sub-millimeter spatial accuracy, both for single-focus mode and for an iterated multi-foci line scan. Near harmonic reference-less PRFS MRT delivered motion-robust thermal maps perpendicular or parallel to the HIFU beam (0.7 °C precision, 0.5 °C absolute accuracy). Out-of-plane motion compensation was not addressed in this study. (note)

  4. Ten-year Biochemical Disease-free Survival After High-intensity Focused Ultrasound (HIFU) for Localized Prostate Cancer: Comparison with Four Different Generation Devices

    HIFU has been recognized as a minimally invasive treatment option for localized prostate cancer. The purpose of the study was to assess with a long-term outcome of HIFU for prostate cancer. From January 1999, a total of 657 patients who had HIFU with at least 2 year follow-up were treated with four different types of Sonablate registered (Focus Surgery, Indianapolis, USA) devices. Thirty-three patients were treated with Sonablate registered 200 (S200) from 1999 to 2001, 406 patients with Sonablate registered 500 (S500) from 2001 to 2005, 200 patients with Sonablate registered 500 version 4 (V4) from 2005-2008 and 19 patients with Sonablate registered 500 TCM (TCM) from 2007. Biochemical disease-free survival rate (bDFS) in all patients was 59% in 8 years. bDFS in 8 years in patients with S200 and S500 groups were 55% and 56%, and bDFS in 4 and 2 years in patients with V4 and TCM group were 72% and 84%, respectively. bDFS in low, intermediate, and high risk groups were 75%, 54%, and 43% in S200/S500 and 93%, 72%, and 58% in V4/TCM group. Negative prostate biopsy rate after HIFU was 97% in S200, 79% in S500, 94% in V4 and 100% in TCM group. HIFU as primary therapy for prostate cancer is indicated in patients with low- and intermediate-risk (T1-T2b N0M0 disease, a Gleason score of ≤7, a PSA level of <20 ng/mL) and a prostate volume of less than 40 mL. The rate of clinical outcome has significantly improved over the years due to technical improvements in the device.

  5. High-intensity focused ultrasound (HIFU) using Sonablate{trade mark, serif} devices for the treatment of localized prostate cancer: 13-year experience

    Uchida, Toyoaki; Tomonaga, Tetsuro; Shoji, Sunao; Kim, Hakushi; Nagata, Yoshihiro

    2012-11-01

    To report on the long-term results of high-intensity focused ultrasound (HIFU) in the treatment of localized prostate cancer. Eight hundred and eighty-four men with prostate cancer treated with Sonablate® (SB) devices were included. All patients were followed for more than 2 years. The patients were divided into three groups: in the first group, 419 patients were treated with SB200/500 from 1999 to 2006; in the second group, 263 patients were treated with SB 500 ver. 4 from 2005 to 2009: in the third group, 202 patients were treated with SB 500 TCM from 2007 up to present. Biochemical failure was defined according to the Phoenix definition (PSA nadir + 2 ng/ml). The mean age, PSA, Gleason score, operation time, and follow-up period in each group were 68, 66 and 67 years, 11.2, 9.7 and 9.3 ng/ml, 6.2, 6.6 and 6.7, 167, 101 and 106 min, and 56, 48 and 36 months, respectively. The biochemical disease-free rate (bDFR) in each group at 5 years was, respectively, 54%, 61% and 84%, and was 50% at 10 years in the SB200/500 group (pprostate biopsy rates in 3 groups were 81%, 92% and 88%, respectively. As post HIFU complications, urethral stricture, acute epididymitis and urinary incontinence were noted in 18.0%, 6.2% and 1.9%, respectively. Rectourethral fistula was occurred in 0.6% in the first HIFU cases, Postoperative erectile dysfunction was noted in 27% of patients at 2 years after HIFU. HIFU therapy appears to be minimally invasive, efficacious, and safe for patients with localized prostate cancer. Technological advances as well as cultural and economic vectors have caused a shift from to minimally invasive techniques.

  6. Ten-year Biochemical Disease-free Survival After High-intensity Focused Ultrasound (HIFU) for Localized Prostate Cancer: Comparison with Four Different Generation Devices

    Uchida, T.; Nakano, M.; Shoji, S.; Omata, T.; Harano, Y.; Nagata, Y.; Usui, Y.; Terachi, T.

    2010-03-01

    HIFU has been recognized as a minimally invasive treatment option for localized prostate cancer. The purpose of the study was to assess with a long-term outcome of HIFU for prostate cancer. From January 1999, a total of 657 patients who had HIFU with at least 2 year follow-up were treated with four different types of Sonablate® (Focus Surgery, Indianapolis, USA) devices. Thirty-three patients were treated with Sonablate® 200 (S200) from 1999 to 2001, 406 patients with Sonablate® 500 (S500) from 2001 to 2005, 200 patients with Sonablate® 500 version 4 (V4) from 2005-2008 and 19 patients with Sonablate® 500 TCM (TCM) from 2007. Biochemical disease-free survival rate (bDFS) in all patients was 59% in 8 years. bDFS in 8 years in patients with S200 and S500 groups were 55% and 56%, and bDFS in 4 and 2 years in patients with V4 and TCM group were 72% and 84%, respectively. bDFS in low, intermediate, and high risk groups were 75%, 54%, and 43% in S200/S500 and 93%, 72%, and 58% in V4/TCM group. Negative prostate biopsy rate after HIFU was 97% in S200, 79% in S500, 94% in V4 and 100% in TCM group. HIFU as primary therapy for prostate cancer is indicated in patients with low- and intermediate-risk (T1-T2b N0M0 disease, a Gleason score of ⩽7, a PSA level of prostate volume of less than 40 mL. The rate of clinical outcome has significantly improved over the years due to technical improvements in the device.

  7. HematoPorphyrin Monomethyl Ether polymer contrast agent for ultrasound/photoacoustic dual-modality imaging-guided synergistic high intensity focused ultrasound (HIFU) therapy.

    Yan, Sijing; Lu, Min; Ding, Xiaoya; Chen, Fei; He, Xuemei; Xu, Chunyan; Zhou, Hang; Wang, Qi; Hao, Lan; Zou, Jianzhong

    2016-01-01

    This study is to prepare a hematoporphyrin monomethyl ether (HMME)-loaded poly(lactic-co-glycolic acid) (PLGA) microcapsules (HMME/PLGA), which could not only function as efficient contrast agent for ultrasound (US)/photoacoustic (PA) imaging, but also as a synergistic agent for high intensity focused ultrasound (HIFU) ablation. Sonosensitizer HMME nanoparticles were integrated into PLGA microcapsules with the double emulsion evaporation method. After characterization, the cell-killing and cell proliferation-inhibiting effects of HMME/PLGA microcapsules on ovarian cancer SKOV3 cells were assessed. The US/PA imaging-enhancing effects and synergistic effects on HIFU were evaluated both in vitro and in vivo. HMME/PLGA microcapsules were highly dispersed with well-defined spherical morphology (357 ± 0.72 nm in diameter, PDI = 0.932). Encapsulation efficiency and drug-loading efficiency were 58.33 ± 0.95% and 4.73 ± 0.15%, respectively. The HMME/PLGA microcapsules remarkably killed the SKOV3 cells and inhibited the cell proliferation, significantly enhanced the US/PA imaging results and greatly enhanced the HIFU ablation effects on ovarian cancer in nude mice by the HMME-mediated sono-dynamic chemistry therapy (SDT). HMME/PLGA microcapsules represent a potential multifunctional contrast agent for HIFU diagnosis and treatment, which might provide a novel strategy for the highly efficient imaging-guided non-invasive HIFU synergistic therapy for cancers by SDT in clinic. PMID:27535093

  8. Yesterday's noise - today's signal

    Plant performance can be improved by noise analysis. This paper describes noise characteristics, imposed noise and response functions, a case history of cost benefits derived from application of noise analysis techniques, areas for application of noise analysis techniques with special reference to the Gentilly-1 nuclear generating station, and the validity of noise measurement results. (E.C.B.)

  9. An improved probe noise approach for acoustic feedback cancellation

    Guo, Meng; Jensen, Søren Holdt; Jensen, Jesper

    The perhaps most challenging problem in acoustic feedback cancellation using adaptive filters is the bias problem. It is well-known that a probe noise approach can effectively prevent this problem. However, when the probe noise must be inaudible and the steady-state error of the adaptive filter...... must be unchanged, this approach causes a significantly decreased convergence rate of the adaptive filter, and might thereby be less useful in practical applications. In this work, we propose a new probe noise approach which significantly increases the convergence rate while maintaining the steady......-state error of the adaptive algorithm in a multiple-microphone and single-loudspeaker audio system. This is obtained through a specifically designed probe noise signal and a corresponding probe noise enhancement strategy. We show the effects of the proposed probe noise approach by deriving analytical...

  10. Development of a Voice Activity Controlled Noise Canceller

    Aini Hussain

    2012-05-01

    Full Text Available In this paper, a variable threshold voice activity detector (VAD is developed to control the operation of a two-sensor adaptive noise canceller (ANC. The VAD prohibits the reference input of the ANC from containing some strength of actual speech signal during adaptation periods. The novelty of this approach resides in using the residual output from the noise canceller to control the decisions made by the VAD. Thresholds of full-band energy and zero-crossing features are adjusted according to the residual output of the adaptive filter. Performance evaluation of the proposed approach is quoted in terms of signal to noise ratio improvements as well mean square error (MSE convergence of the ANC. The new approach showed an improved noise cancellation performance when tested under several types of environmental noise. Furthermore, the computational power of the adaptive process is reduced since the output of the adaptive filter is efficiently calculated only during non-speech periods.

  11. Volumetric MR-HIFU ablation of uterine fibroids: Role of treatment cell size in the improvement of energy efficiency

    Purpose: To evaluate the energy efficiency of differently sized volumetric ablations in MR-guided high-intensity focused ultrasound (MR-HIFU) treatment of uterine fibroids. Materials and methods: This study was approved by the institutional review board and informed consent was obtained from all participants. Ten symptomatic uterine fibroids (mean diameter 8.9 cm) in 10 women (mean age 42.2) were treated by volumetric MR-HIFU ablation under binary feedback control. The energy efficiency (mm3/J) of each sonication was calculated as the volume of lethal thermal dose (240 equivalent minutes at 43 °C) per unit acoustic energy applied. Operator-controllable parameters and signal intensity ratio of uterine fibroid to skeletal muscle on T2-weighted MR images were tested with univariate and multivariate analyses to discern which parameters significantly correlated with the ablation energy efficiency. Results: We analyzed a total of 236 sonications. The energy efficiency of the ablations was 0.42 ± 0.25 mm3/J (range 0.004–1.18) with energy efficiency improving with the treatment cell size (4 mm, 0.06 ± 0.06 mm3/J; 8 mm, 0.29 ± 0.12 mm3/J; 12 mm, 0.58 ± 0.18 mm3/J; 16 mm, 0.91 ± 0.17 mm3/J). Treatment cell size (r = 0.814, p < 0.001), distance of ultrasound propagation (r = −0.151, p = 0.020), sonication frequency (1.2 or 1.45 MHz; p < 0.001), and signal intensity ratio (r = −0.205, p = 0.002) proved to be significant by univariate analysis, while multivariate analysis revealed treatment cell size (B = 0.075, p < 0.001), US propagation distance (B = −6.928, p < 0.001), and signal intensity ratio (B = −0.024, p = 0.001) to be independently significant. Conclusion: Energy efficiency in volumetric MR-HIFU ablation of uterine fibroids improves with increased treatment cell size, independent of other significant contributors such as distance of ultrasound propagation or signal intensity of the tumor on T2-weighted MR imaging.

  12. Volumetric MR-HIFU ablation of uterine fibroids: Role of treatment cell size in the improvement of energy efficiency

    Kim, Young-sun [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Keserci, Bilgin [Philips Healthcare, Seoul (Korea, Republic of); Partanen, Ari [Philips Healthcare, Cleveland, OH (United States); Rhim, Hyunchul, E-mail: rhimhc@skku.edu [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Lim, Hyo K.; Park, Min Jung [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of); Koehler, Max O. [Philips Healthcare, Vantaa (Finland)

    2012-11-15

    Purpose: To evaluate the energy efficiency of differently sized volumetric ablations in MR-guided high-intensity focused ultrasound (MR-HIFU) treatment of uterine fibroids. Materials and methods: This study was approved by the institutional review board and informed consent was obtained from all participants. Ten symptomatic uterine fibroids (mean diameter 8.9 cm) in 10 women (mean age 42.2) were treated by volumetric MR-HIFU ablation under binary feedback control. The energy efficiency (mm{sup 3}/J) of each sonication was calculated as the volume of lethal thermal dose (240 equivalent minutes at 43 Degree-Sign C) per unit acoustic energy applied. Operator-controllable parameters and signal intensity ratio of uterine fibroid to skeletal muscle on T2-weighted MR images were tested with univariate and multivariate analyses to discern which parameters significantly correlated with the ablation energy efficiency. Results: We analyzed a total of 236 sonications. The energy efficiency of the ablations was 0.42 {+-} 0.25 mm{sup 3}/J (range 0.004-1.18) with energy efficiency improving with the treatment cell size (4 mm, 0.06 {+-} 0.06 mm{sup 3}/J; 8 mm, 0.29 {+-} 0.12 mm{sup 3}/J; 12 mm, 0.58 {+-} 0.18 mm{sup 3}/J; 16 mm, 0.91 {+-} 0.17 mm{sup 3}/J). Treatment cell size (r = 0.814, p < 0.001), distance of ultrasound propagation (r = -0.151, p = 0.020), sonication frequency (1.2 or 1.45 MHz; p < 0.001), and signal intensity ratio (r = -0.205, p = 0.002) proved to be significant by univariate analysis, while multivariate analysis revealed treatment cell size (B = 0.075, p < 0.001), US propagation distance (B = -6.928, p < 0.001), and signal intensity ratio (B = -0.024, p = 0.001) to be independently significant. Conclusion: Energy efficiency in volumetric MR-HIFU ablation of uterine fibroids improves with increased treatment cell size, independent of other significant contributors such as distance of ultrasound propagation or signal intensity of the tumor on T2-weighted MR

  13. Nonequilibrium Spin Noise and Noise of Susceptibility

    Schad, Pablo; Narozhny, Boris N.; Schön, Gerd; Shnirman, Alexander

    2014-01-01

    We analyze out-of-equilibrium fluctuations in a driven spin system and relate them to the noise of spin susceptibility. In the spirit of the linear response theory we further relate the noise of susceptibility to a $4$-spin correlation function in equilibrium. We show that, in contrast to the second noise (noise of noise), the noise of susceptibility is a direct measure of non-Gaussian fluctuations in the system. We develop a general framework for calculating the noise of susceptibility using...

  14. Quantum Noise

    Quantum Noise is advertised as a handbook, and this is indeed how it functions for me these days: it is a book that I keep within hand's reach, ready to be consulted on the proper use of quantum stochastic methods in the course of my research on quantum dots. I should point out that quantum optics, the target field for this book, is not my field by training. So I have much to learn, and find this handbook to be a reliable and helpful guide. Crispin Gardiner previously wrote the Handbook of Stochastic Methods (also published by Springer), which provides an overview of methods in classical statistical physics. Quantum Noise, written jointly with Peter Zoller, is the counterpart for quantum statistical physics, and indeed the two books rely on each other by frequent cross referencing. The fundamental problem addressed by Quantum Noise is how the quantum dynamics of an open system can be described statistically by treating the environment as a source of noise. This is a general problem in condensed matter physics (in particular in the context of Josephson junctions) and in quantum optics. The emphasis in this book in on the optical applications (for condensed matter applications one could consult Quantum Dissipative Systems by Ulrich Weiss, published by World Scientific). The optical applications centre around the interaction of light with atoms, where the atoms represent the open system and the light is the noisy environment. A complete description of the production and detection of non-classical states of radiation (such as squeezed states) can be obtained using one of the equivalent quantum stochastic formulations: the quantum Langevin equation for the field operators (in either the Ito or the Stratonovich form), the Master equation for the density matrix, or the stochastic Schroedinger equation for the wave functions. Each formulation is fully developed here (as one would expect from a handbook), with detailed instructions on how to go from one to the other. The

  15. An MR-compliant phased-array HIFU transducer with augmented steering range, dedicated to abdominal thermotherapy

    A novel architecture for a phased-array high intensity focused ultrasound (HIFU) device was investigated, aiming to increase the capabilities of electronic steering without reducing the size of the elementary emitters. The principal medical application expected to benefit from these developments is the time-effective sonication of large tumours in moving organs. The underlying principle consists of dividing the full array of transducers into multiple sub-arrays of different resonance frequencies, with the reorientation of these individual emitters, such that each sub-array can focus within a given spatial zone. To enable magnetic resonance (MR) compatibility of the device and the number of output channels from the RF generator to be halved, a passive spectral multiplexing technique was used, consisting of parallel wiring of frequency-shifted paired piezoceramic emitters with intrinsic narrow-band response. Two families of 64 emitters (circular, 5 mm diameter) were mounted, with optimum efficiency at 0.96 and 1.03 MHz, respectively. Two different prototypes of the HIFU device were built and tested, each incorporating the same two families of emitters, but differing in the shape of the rapid prototyping plastic support that accommodated the transducers (spherical cap with radius of curvature/aperture of 130 mm/150 mm and, respectively, 80 mm/110 mm). Acoustic measurements, MR-acoustic radiation force imaging (ex vivo) and MR-thermometry (ex vivo and in vivo) were used for the characterization of the prototypes. Experimental results demonstrated an augmentation of the steering range by 80% along one preferentially chosen axis, compared to a classic spherical array of the same total number of elements. The electric power density provided to the piezoceramic transducers exceeded 50 W cm-2 CW, without circulation of coolant water. Another important advantage of the current approach is the versatility of reshaping the array at low cost.

  16. An MR-compliant phased-array HIFU transducer with augmented steering range, dedicated to abdominal thermotherapy

    Auboiroux, Vincent [Inserm, U556, Lyon, F-69003 (France); Dumont, Erik [Image Guided Therapy, Pessac, Bordeaux (France); Petrusca, Lorena; Salomir, Rares [Faculty of Medicine, University of Geneva (Switzerland); Viallon, Magalie, E-mail: vincent.auboiroux@unige.ch [Radiology Department, University Hospital of Geneva, Geneva (Switzerland)

    2011-06-21

    A novel architecture for a phased-array high intensity focused ultrasound (HIFU) device was investigated, aiming to increase the capabilities of electronic steering without reducing the size of the elementary emitters. The principal medical application expected to benefit from these developments is the time-effective sonication of large tumours in moving organs. The underlying principle consists of dividing the full array of transducers into multiple sub-arrays of different resonance frequencies, with the reorientation of these individual emitters, such that each sub-array can focus within a given spatial zone. To enable magnetic resonance (MR) compatibility of the device and the number of output channels from the RF generator to be halved, a passive spectral multiplexing technique was used, consisting of parallel wiring of frequency-shifted paired piezoceramic emitters with intrinsic narrow-band response. Two families of 64 emitters (circular, 5 mm diameter) were mounted, with optimum efficiency at 0.96 and 1.03 MHz, respectively. Two different prototypes of the HIFU device were built and tested, each incorporating the same two families of emitters, but differing in the shape of the rapid prototyping plastic support that accommodated the transducers (spherical cap with radius of curvature/aperture of 130 mm/150 mm and, respectively, 80 mm/110 mm). Acoustic measurements, MR-acoustic radiation force imaging (ex vivo) and MR-thermometry (ex vivo and in vivo) were used for the characterization of the prototypes. Experimental results demonstrated an augmentation of the steering range by 80% along one preferentially chosen axis, compared to a classic spherical array of the same total number of elements. The electric power density provided to the piezoceramic transducers exceeded 50 W cm{sup -2} CW, without circulation of coolant water. Another important advantage of the current approach is the versatility of reshaping the array at low cost.

  17. 11C choline PET guided salvage radiotherapy with volumetric modulation arc therapy and hypofractionation for recurrent prostate cancer after HIFU failure: preliminary results of tolerability and acute toxicity.

    Alongi, Filippo; Liardo, Rocco L E; Iftode, Cristina; Lopci, Egesta; Villa, Elisa; Comito, Tiziana; Tozzi, Angelo; Navarria, Pierina; Ascolese, Anna M; Mancosu, Pietro; Tomatis, Stefano; Bellorofonte, Carlo; Arturo, Chiti; Scorsetti, Marta

    2014-10-01

    The purpose of this work was to evaluate tolerance, feasibility and acute toxicity in patients undergoing salvage radiotherapy after high-intensity focused ultrasound (HIFU) failure. From 2005 to 2011 a total of 15 patients were treated with HIFU as primary radical treatment. Between July 2011 and February 2013, all 15 patients presented biochemical relapse after HIFU and 11C choline PET documenting intrapostatic-only failure. Salvage EBRT was performed with moderate hypofractionation schedule in 28 fractions with volumetric modulation arc therapy (VMAT). Genito-urinary (GU) and rectal and bowel toxicity were scored by common terminology criteria for adverse events version 4 (CTCAE V.4) scale. Biochemical response was assessed by ASTRO Phoenix criteria. Median age of patients was 67 years (range: 53-85). The median Gleason score was 7 (range: 6-9). The median prostate specific antigen (PSA) at the time of biochemical relapse after HIFU was 5.2 ng/mL (range: 2-64.2). Seven of the 15 patients received androgen deprivation therapy (ADT) started after HIFU failure, interrupted before 11C choline PET and radiotherapy. Median prescribed dose was 71.4 Gy (range: 71.4-74.2 Gy) in 28 fractions. No radiation related major upper gastrointestinal (GI), rectal and GU toxicity were experienced. GU, acute grade 1 and grade 2 toxicities were recorded in 7/15 and 4/15 respectively; bowel acute grade 1 and grade 2 toxicities in 4/15 and 1/15; rectal acute grade 1 and grade 2 toxicities in 3/15 and 2/15 respectively. No grade 3 or greater acute or late toxicities occurred. Biochemical control was assessed in 12/15 (80%) patients. With a median follow up of 12 months, three out of 15 patients, with biochemical relapse, showed lymph-nodal recurrence. Our early clinical results and biochemical data confirm the feasibility and show a good tolerance of the 11C choline PET guided salvage radiation therapy after HIFU failure. The findings of low acute toxicity is encouraging, but longer

  18. Non-Invasive Targeted Peripheral Nerve Ablation Using 3D MR Neurography and MRI-Guided High-Intensity Focused Ultrasound (MR-HIFU): Pilot Study in a Swine Model

    Huisman, Merel; Staruch, Robert M.; Ladouceur-Wodzak, Michelle; van den Bosch, Maurice A.; Burns, Dennis K.; Chhabra, Avneesh; Chopra, Rajiv

    2015-01-01

    Purpose Ultrasound (US)-guided high intensity focused ultrasound (HIFU) has been proposed for noninvasive treatment of neuropathic pain and has been investigated in in-vivo studies. However, ultrasound has important limitations regarding treatment guidance and temperature monitoring. Magnetic resonance (MR)-imaging guidance may overcome these limitations and MR-guided HIFU (MR-HIFU) has been used successfully for other clinical indications. The primary purpose of this study was to evaluate the feasibility of utilizing 3D MR neurography to identify and guide ablation of peripheral nerves using a clinical MR-HIFU system. Methods Volumetric MR-HIFU was used to induce lesions in the peripheral nerves of the lower limbs in three pigs. Diffusion-prep MR neurography and T1-weighted images were utilized to identify the target, plan treatment and immediate post-treatment evaluation. For each treatment, one 8 or 12 mm diameter treatment cell was used (sonication duration 20 s and 36 s, power 160–300 W). Peripheral nerves were extracted HIFU. Diffusion-prep 3D MR neurography has potential for guiding therapy procedures where either nerve targeting or avoidance is desired, and may also have potential for post-treatment verification of thermal lesions without contrast injection. PMID:26659073

  19. Effect of train noise on sleep for people living in houses bordering the railway line

    Vernet, M

    1979-01-01

    Disturbance of sleep by train and road noises was studied through in situ physiological recordings. For the same value of L/sub eq/ three times as many disturbances due to the noise from road traffic were found as there were due to the train noise. The data on sleep reactions for all the noise events do not show a better train noise adaptation than those for the road noise. (8 refs).

  20. Inhibitory noise

    Alain Destexhe

    2010-03-01

    Full Text Available Cortical neurons in vivo may operate in high-conductance states, in which the major part of the neuron's input conductance is due to synaptic activity, sometimes several-fold larger than the resting conductance. We examine here the contribution of inhibition in such high-conductance states. At the level of the absolute conductance values, several studies have shown that cortical neurons in vivo are characterized by strong inhibitory conductances. However, conductances are balanced and spiking activity is mostly determined by fluctuations, but not much is known about excitatory and inhibitory contributions to these fluctuations. Models and dynamic-clamp experiments show that, during high-conductance states, spikes are mainly determined by fluctuations of inhibition, or by inhibitory noise. This stands in contrast to low-conductance states, in which excitatory conductances determine spiking activity. To determine these contributions from experimental data, maximum likelihood methods can be designed and applied to intracellular recordings in vivo. Such methods indicate that action potentials are indeed mostly correlated with inhibitory fluctuations in awake animals. These results argue for a determinant role for inhibitory fluctuations in evoking spikes, and do not support feed-forward modes of processing, for which opposite patterns are predicted.

  1. Noise and Hearing Protection

    ... Meeting Calendar Find an ENT Doctor Near You Noise and Hearing Protection Noise and Hearing Protection Patient ... it is. How can I tell if a noise is dangerous? People differ in their sensitivity to ...

  2. Noise-Measuring Method

    Diamond, J. M.

    1965-01-01

    A noise-measuring method based on the use of a calibrated noise generator and an output meter with a special scale is described. The method eliminates the effect of noise contributions occurring in the circuits following the device under test.......A noise-measuring method based on the use of a calibrated noise generator and an output meter with a special scale is described. The method eliminates the effect of noise contributions occurring in the circuits following the device under test....

  3. Experimental investigation of thermal effects in HIFU-based external valvuloplasty with a non-spherical transducer, using high-resolution MR thermometry

    Petrusca, Lorena; Salomir, Rares; Milleret, Rene; Pichot, Olivier; Rata, Mihaela; Chapelon, Jean-Yves [Inserm, U556, and Universite de Lyon, Lyon, F-69003 (France); Cotton, Francois [Universite Claude Bernard Lyon 1, Lyon, F-69003 (France)], E-mail: lorena.petrusca@inserm.fr

    2009-09-07

    Real-time image-guided extracorporeal high intensity focused ultrasound (HIFU) has been suggested for minimally invasive treatment of valvular dysfunction in the saphenous vein. Local application of heat on the perimeter of the valve zone was previously reported to induce a partial shrinkage of the collagen, which may correct valvular function. In our study, a novel MR compatible HIFU device has been investigated. This device is based on a non-spherical geometry, with two active elements that create a focusing line which is orthogonal to the beam main axis, aiming to cover the valve longitudinally. The prototype performance was characterized by electro-acoustical measurements of the pressure field and by high-resolution MR thermometry. Pressure and thermal fields were found in good agreement with the theoretical predictions. To investigate the therapeutic potential, fresh samples of excised human veins were filled with an agarose gel, embedded in porcine muscle and exposed to HIFU. The power level applied during a fixed duration of 30 s was varied such that the absolute temperature at focus ranged between 52 deg. C and 83 deg. C. Targeting was achieved under MR guidance using a MR compatible XZ positioning system. A dedicated waterproof miniature loop coil was specifically built to achieve high-resolution MRI image-based targeting (0.25 mm x 0.25 mm x 3 mm voxel) and thermometry (0.4 mm x 0.4 mm x 4 mm voxel). The vein wall was clearly identified on MR images before and after HIFU treatment. The thermal buildup created by the non-spherical transducer could be characterized from MR thermometry data. Shrinkage of the vein wall (above 65 deg. C) was determined by absolute temperature and was not a cumulative thermal dose effect.

  4. Experimental investigation of thermal effects in HIFU-based external valvuloplasty with a non-spherical transducer, using high-resolution MR thermometry

    Real-time image-guided extracorporeal high intensity focused ultrasound (HIFU) has been suggested for minimally invasive treatment of valvular dysfunction in the saphenous vein. Local application of heat on the perimeter of the valve zone was previously reported to induce a partial shrinkage of the collagen, which may correct valvular function. In our study, a novel MR compatible HIFU device has been investigated. This device is based on a non-spherical geometry, with two active elements that create a focusing line which is orthogonal to the beam main axis, aiming to cover the valve longitudinally. The prototype performance was characterized by electro-acoustical measurements of the pressure field and by high-resolution MR thermometry. Pressure and thermal fields were found in good agreement with the theoretical predictions. To investigate the therapeutic potential, fresh samples of excised human veins were filled with an agarose gel, embedded in porcine muscle and exposed to HIFU. The power level applied during a fixed duration of 30 s was varied such that the absolute temperature at focus ranged between 52 deg. C and 83 deg. C. Targeting was achieved under MR guidance using a MR compatible XZ positioning system. A dedicated waterproof miniature loop coil was specifically built to achieve high-resolution MRI image-based targeting (0.25 mm x 0.25 mm x 3 mm voxel) and thermometry (0.4 mm x 0.4 mm x 4 mm voxel). The vein wall was clearly identified on MR images before and after HIFU treatment. The thermal buildup created by the non-spherical transducer could be characterized from MR thermometry data. Shrinkage of the vein wall (above 65 deg. C) was determined by absolute temperature and was not a cumulative thermal dose effect.

  5. Low Complexity Expert Dependent Noise Filtration Algorithm

    Sasi Rekha.Sanivarapu; P.Padmaja Priyadarsini; Dr.M.VenuGopala Rao

    2012-01-01

    In this paper, a flexible and robust wavelet based image denoising algorithm is proposed, which adapts itself to various and unknown types of noise as well as to the preference of the medical expert: a single tuning parameter is used to balance the preservation of relevant details against the degree of noise reduction. We employ a preliminary coefficient classification technique to empirically estimate the statistical distributions of the coefficients that represent useful image features on t...

  6. MR thermometry analysis program for laser- or high-intensity focused ultrasound (HIFU)-induced heating at a clinical MR scanner

    Kim, Eun Ju; Jeong, Kiyoung; Oh, Seung Jae; Kim, Daehong; Park, Eun Hae; Lee, Young Han; Suh, Jin-Suck

    2014-12-01

    Magnetic resonance (MR) thermometry is a noninvasive method for monitoring local temperature change during thermal therapy. In this study, a MR temperature analysis program was established for a laser with gold nanorods (GNRs) and high-intensity focused ultrasound (HIFU)-induced heating MR thermometry. The MR temperature map was reconstructed using the water proton resonance frequency (PRF) method. The temperature-sensitive phase difference was acquired by using complex number subtraction instead of direct phase subtraction in order to avoid another phase unwrapping process. A temperature map-analyzing program was developed and implemented in IDL (Interactive Data Language) for effective temperature monitoring. This one program was applied to two different heating devices at a clinical MR scanner. All images were acquired with the fast spoiled gradient echo (fSPGR) pulse sequence on a 3.0 T GE Discovery MR750 scanner with an 8-channel knee array coil or with a home-built small surface coil. The analyzed temperature values were confirmed by using values simultaneously measured with an optical temperature probe (R2 = 0.996). The temperature change in small samples induced by a laser or by HIFU was analyzed by using a raw data, that consisted of complex numbers. This study shows that our MR thermometry analysis program can be used for thermal therapy study with a laser or HIFU at a clinical MR scanner. It can also be applied to temperature monitoring for any other thermal therapy based on the PRF method.

  7. Multi-Angle Switched HIFU: A New Ultrasound Device for Controlled Non-Invasive Induction of Small Spherical Ablation Zones—Simulation and Ex-Vivo Results

    Novák, Petr; Jamshidi-Parsian, Azemat; Benson, Donny G.; Webber, Jessica S.; Moros, Eduardo G.; Shafirstein, Gal; Griffin, Robert J.

    2009-04-01

    Current HIFU devices produce elongated elliptical lesions (cigar shaped) in a single energy deposition. This prohibits the effective use of HIFU in small animal research as well as in clinical treatment where small volumes of tissue surrounded by critical structures need to be destroyed. We developed an ultrasound ablation device that non-invasively creates spheroidal lesions of an arbitrary diameter of up to 1 cm in a depth of up to 5 cm. The device consists of two focused ultrasound transducers aimed to the ablation target volume from two directions at a 90 degree angle. The operation of the transducers is switched back and forth so that only one transducer is energized at a time. A transient analysis of this ablation approach was performed using coupled simulations of acoustical pressure distributions, resulting temperature distributions, and thermal dose deposited to soft tissue. A prototype of the device was developed and tested in-vitro in a phantom and later in ex-vivo experiments in pig liver. The experimental results agreed with the numerical simulations and confirmed the ability of the multi-angle switched HIFU (MASH) device to create small spheroidal lesions in soft tissue within 2 minutes without significantly affecting the surrounding tissues.

  8. Improved Noise Minimum Statistics Estimation Algorithm for Using in a Speech-Passing Noise-Rejecting Headset

    Seyedtabaee, Saeed; Moazami Goodarzi, Hamze

    2010-12-01

    This paper deals with configuration of an algorithm to be used in a speech-passing angle grinder noise-canceling headset. Angle grinder noise is annoying and interrupts ordinary oral communication. Meaning that, low SNR noisy condition is ahead. Since variation in angle grinder working condition changes noise statistics, the noise will be nonstationary with possible jumps in its power. Studies are conducted for picking an appropriate algorithm. A modified version of the well-known spectral subtraction shows superior performance against alternate methods. Noise estimation is calculated through a multi-band fast adapting scheme. The algorithm is adapted very quickly to the non-stationary noise environment while inflecting minimum musical noise and speech distortion on the processed signal. Objective and subjective measures illustrating the performance of the proposed method are introduced.

  9. Wind turbine noise. Primary noise sources

    Oerlemans, S.

    2011-04-15

    Wind is a clean, cheap, and inexhaustible source of energy. However, the noise from wind turbines constitutes an important hindrance for the widespread application of wind energy. As a result, there is considerable interest in wind turbine noise, from a number of angles. As public clamour grows from those living near turbines, and misinformation and disinformation begin to take root, there is a clear need for a scientifically accurate book to give an account of the noise generated, its effects on people, and possible remedies either through technology or legislation or both. The different potential source mechanisms are described and the theoretical characteristics of flowinduced sound from wind turbine blades are explained. The noise sources on wind turbines are characterized experimentally by means of wind tunnel and field experiments. Methods to predict and reduce wind turbine noise are discussed. The dominant noise source for typical modern large wind turbines is broadband trailing edge noise from the outer part of the blades. The swishing character of the sound can be explained by trailing edge noise directivity and convective amplification. A semi-analytical, semi-empirical prediction method can accurately predict the characteristics of wind turbine noise. Wind turbine noise can be halved by means of serrations, without adverse effects on the aerodynamic performance. The book is aimed at people with a personal or professional involvement in wind turbine noise, such as environmental health or public health practitioners, wind farm developers or informed wind farm supporters and objectors.

  10. Inhibition of Fuze Noise AM Interference Based on Adaptive Filter%基于自适应滤波的引信噪声调幅干扰抑制

    宋扬; 关赛飞; 路翠华; 刘华章

    2013-01-01

    噪声调幅干扰是一种有效的压制性干扰,可压制近炸无线电引信对目标信息的获取。为提高连续波多普勒无线电引信抗噪声调幅干扰的能力,将单频率自适应陷波器应用到连续波多普勒引信中,对噪声调幅干扰进行抑制。分析了噪声干扰抑制原理,并对噪声干扰抑制效果进行了仿真。仿真结果表明:SJR=-10 dB时,仍然能达到很好的噪声调幅干扰抑制效果。%Noise AM interference can prevent a proximity radio fuze form getting target information. In order to improve the ability of continuous-wave Doppler fuze to anti-noise AM interference, notch filter was adopted to suppress noise AM in-terference. Principle of anti-noise jamming was analyzed and the suppressing effect was simulated. The simulation results showed that when SNR=-10 dB, noise AM interference could still be suppressed effectively.

  11. Multi-parametric monitoring and assessment of high-intensity focused ultrasound (HIFU) boiling by harmonic motion imaging for focused ultrasound (HMIFU): an ex vivo feasibility study

    Harmonic motion imaging for focused ultrasound (HMIFU) is a recently developed high-intensity focused ultrasound (HIFU) treatment monitoring method with feasibilities demonstrated in vitro and in vivo. Here, a multi-parametric study is performed to investigate both elastic and acoustics-independent viscoelastic tissue changes using the Harmonic Motion Imaging (HMI) displacement, axial compressive strain and change in relative phase shift during high energy HIFU treatment with tissue boiling. Forty three (n = 43) thermal lesions were formed in ex vivo canine liver specimens (n = 28). Two-dimensional (2D) transverse HMI displacement maps were also obtained before and after lesion formation. The same method was repeated in 10 s, 20 s and 30 s HIFU durations at three different acoustic powers of 8, 10, and 11 W, which were selected and verified as treatment parameters capable of inducing boiling using both thermocouple and passive cavitation detection (PCD) measurements. Although a steady decrease in the displacement, compressive strain, and relative change in the focal phase shift (Δϕ) were obtained in numerous cases, indicating an overall increase in relative stiffness, the study outcomes also showed that during boiling, a reverse lesion-to-background displacement contrast was detected, indicating potential change in tissue absorption, geometrical change and/or, mechanical gelatification or pulverization. Following treatment, corresponding 2D HMI displacement images of the thermal lesions also mapped consistent discrepancy in the lesion-to-background displacement contrast. Despite the expectedly chaotic changes in acoustic properties with boiling, the relative change in phase shift showed a consistent decrease, indicating its robustness to monitor biomechanical properties independent of the acoustic property changes throughout the HIFU treatment. In addition, the 2D HMI displacement images confirmed and indicated the increase in the thermal lesion size with

  12. Multi-parametric monitoring and assessment of high-intensity focused ultrasound (HIFU) boiling by harmonic motion imaging for focused ultrasound (HMIFU): an ex vivo feasibility study

    Hou, Gary Y.; Marquet, Fabrice; Wang, Shutao; Konofagou, Elisa E.

    2014-03-01

    Harmonic motion imaging for focused ultrasound (HMIFU) is a recently developed high-intensity focused ultrasound (HIFU) treatment monitoring method with feasibilities demonstrated in vitro and in vivo. Here, a multi-parametric study is performed to investigate both elastic and acoustics-independent viscoelastic tissue changes using the Harmonic Motion Imaging (HMI) displacement, axial compressive strain and change in relative phase shift during high energy HIFU treatment with tissue boiling. Forty three (n = 43) thermal lesions were formed in ex vivo canine liver specimens (n = 28). Two-dimensional (2D) transverse HMI displacement maps were also obtained before and after lesion formation. The same method was repeated in 10 s, 20 s and 30 s HIFU durations at three different acoustic powers of 8, 10, and 11 W, which were selected and verified as treatment parameters capable of inducing boiling using both thermocouple and passive cavitation detection (PCD) measurements. Although a steady decrease in the displacement, compressive strain, and relative change in the focal phase shift (Δϕ) were obtained in numerous cases, indicating an overall increase in relative stiffness, the study outcomes also showed that during boiling, a reverse lesion-to-background displacement contrast was detected, indicating potential change in tissue absorption, geometrical change and/or, mechanical gelatification or pulverization. Following treatment, corresponding 2D HMI displacement images of the thermal lesions also mapped consistent discrepancy in the lesion-to-background displacement contrast. Despite the expectedly chaotic changes in acoustic properties with boiling, the relative change in phase shift showed a consistent decrease, indicating its robustness to monitor biomechanical properties independent of the acoustic property changes throughout the HIFU treatment. In addition, the 2D HMI displacement images confirmed and indicated the increase in the thermal lesion size with

  13. Kombination aus TUR-P und hochintensiv fokussiertem Ultraschall (HIFU zur Behandlung des lokoregionären Prostatakarzinoms - Erfahrungen mit 70 Patienten

    Walter B

    2004-01-01

    Full Text Available Ziel: HIFU ist eine minimal invasive Behandlungsalternative des lokoregionären Prostatakarzinoms. Eine vorgeschaltete TUR-P verkleinert die Drüse, insbesondere die meist karzinomfreie Transitionalzone, so daß sich die Behandlung im Idealfall ganz auf die peripheren Drüsenanteile konzentrieren kann. Zudem sollte durch die Resektion der Zeitraum einer allfälligen ödembedingten postoperativen Blasenauslaßobstruktion verkürzt werden. Patienten und Methoden: Wir haben 70 Patienten mit bioptisch gesichertem, lokoregionärem Prostatakarzinom (T1/T2, N0, M0 mit einer Kombination aus TUR-P und HIFU (Ablatherm-Gerät, EDAP, Lyon, Frankreich behandelt. Die Einschlußkriterien umfaßten einen PSA-Wert 15 ng/ml und einen Gleason-Score 7. Das mittlere Patientenalter lag bei 66,78 (± 6,3 Jahren, der mittlere PSA-Wert bei 7,25 ± (3,5 ng/ml, und der mittlere Gleason-Score bei 5,1 (± 1,2. Das initiale Prostatavolumen lag bei 32 (± 11,6 cm3 und wurde durch die TUR-P auf 22,8 (± 7,2 cm3 reduziert. Das Nachsorgeintervall betrug durchschnittlich 15 (± 6,8 Monate. Das Follow-up beinhaltete bei allen Patienten PSA-Kontrollen und Biopsien der Restdrüse. Die Daten von allen 70 Patienten konnten ausgewertet werden. Ergebnisse: Der PSA-Nadir lag im Mittel bei 0,14 (± 0,34 ng/ml und wurde nach 3 Monaten erreicht. Der durchschnittliche PSA-Wert der letzten Kontrolle betrug 0,21 (± 0,38 ng/ml. 94 % der Patienten zeigten negative Kontrollbiopsien. Die postoperative Katheterverweildauer lag bei durchschnittlich 7 Tagen (± 4,2. Bei 13,6 % der Patienten trat eine urodynamisch wirksame Blasenauslaßobstruktion auf, bei der konsekutiv endoskopisch interveniert werden mußte. IPS-Score und Quality of Life Index haben sich durch die Behandlung nicht signifikant geändert. Diskussion: Durch die vorgeschaltete TUR-P ist die Drüsengröße kaum noch ein Ausschlußkriterium für eine HIFU. Die postoperative ödembedingte infravesikale Obstruktion läßt sich gegen

  14. Noise, Health, and Architecture.

    Beranek, Leo L.

    There is reasonable agreement that hearing impairment is related to noise exposure. This hearing loss due to noise is considered a serious health injury, but there is still difficulty in delineating the importance of noise related to people's general non-auditory well-being and health. Beside hearing loss, noise inhibits satisfactory speech…

  15. Can Noise Kill People?

    刘玲娣

    2007-01-01

    Someone is singing next door,but you feel unhappy because her singing is just making a noise.We know that too much noise makes people feel terrible. Scientists are still trying to find out more about noise,but already it is known that a noise of over 85 decibels can make some people tired and anxious.

  16. Immersion Into Noise

    Nechvatal, Joseph

    2011-01-01

    Joseph Nechvatal's Immersion Into Noise investigates multiple aspects of cultural noise by applying our audio understanding of noise to the visual, architectual and cognative domains. The author takes the reader through phenomenal aspects of the art of noise into algorithmic and network contexts, beginning in the Abside of the Grotte de Lascaux.

  17. Active noise cancellation in hearing devices

    2013-01-01

    Disclosed is a hearing device system comprising at least one hearing aid circuitry and at least one active noise cancellation unit, the at least one hearing aid circuitry comprises at least one input transducer adapted to convert a first audio signal to an electric audio signal; a signal processor...... connected to the at least one input transducer and adapted to process said electric audio signal by at least partially correcting for a hearing loss of a user; an output transducer adapted to generate from at least said processed electric audio signal a sound pressure in an ear canal of the user, whereby...... addition to said generated sound pressure, wherein the hearing device system further comprises a combiner unit adapted to combine the processed electric audio signal with the active noise cancellation signal, to obtain a combined signal and to provide the combined signal to the output transducer....

  18. Non-Markovian noise

    The properties of non-Markovian noises with exponentially correlated memory are discussed. Considered are dichotomic noise, white shot noise, Gaussian white noise, and Gaussian colored noise. The stationary correlation functions of the non-Markovian versions of these noises are given by linear combinations of two or three exponential functions (colored noises) or of the δ function and exponential function (white noises). The non-Markovian white noises are well defined only when the kernel of the non-Markovian master equation contains a nonzero admixture of a Markovian term. Approximate equations governing the probability densities for processes driven by such non-Markovian noises are derived, including non-Markovian versions of the Fokker-Planck equation and the telegrapher's equation. As an example, it is shown how the non-Markovian nature changes the behavior of the driven linear process

  19. Adaptations, exaptations, and spandrels.

    Buss, D M; Haselton, M G; Shackelford, T K; Bleske, A L; Wakefield, J C

    1998-05-01

    Adaptation and natural selection are central concepts in the emerging science of evolutionary psychology. Natural selection is the only known causal process capable of producing complex functional organic mechanisms. These adaptations, along with their incidental by-products and a residue of noise, comprise all forms of life. Recently, S. J. Gould (1991) proposed that exaptations and spandrels may be more important than adaptations for evolutionary psychology. These refer to features that did not originally arise for their current use but rather were co-opted for new purposes. He suggested that many important phenomena--such as art, language, commerce, and war--although evolutionary in origin, are incidental spandrels of the large human brain. The authors outline the conceptual and evidentiary standards that apply to adaptations, exaptations, and spandrels and discuss the relative utility of these concepts for psychological science. PMID:9612136

  20. Mechanics of underwater noise

    Ross, Donald

    1976-01-01

    Mechanics of Underwater Noise elucidates the basic mechanisms by which noise is generated, transmitted by structures and radiated into the sea. Organized into 10 chapters, this book begins with a description of noise, decibels and levels, significance of spectra, and passive sonar equation. Subsequent chapters discuss sound waves in liquids; acoustic radiation fundamentals; wind-generated ocean ambient noise; vibration isolation and structural damping; and radiation by plate flexural vibrations. Other chapters address cavitation, propeller cavitation noise, radiation by fluctuating-force (dipo

  1. Noise sustained propagation: Local versus global noise

    Locher, M.; Chatterjee, N.; Marchesoni, F.; Ditto, W. L.; Hunt, E. R.

    2000-01-01

    We expand on prior results on noise supported signal propagation in arrays of coupled bistable elements. We present and compare experimental and numerical results for kink propagation under the influence of local and global fluctuations. As demonstrated previously for local noise, an optimum range of global noise power exists for which the medium acts as a reliable transmission ``channel''. We discuss implications for propagation failure in a model of cardiac tissue and present a general theo...

  2. Active noise cancellation algorithms for impulsive noise

    Li, Peng; Yu, Xun

    2012-01-01

    Impulsive noise is an important challenge for the practical implementation of active noise control (ANC) systems. The advantages and disadvantages of popular filtered-X least mean square (FXLMS) ANC algorithm and nonlinear filtered-X least mean M-estimate (FXLMM) algorithm are discussed in this paper. A new modified FXLMM algorithm is also proposed to achieve better performance in controlling impulsive noise. Computer simulations and experiments are carried out for all three algorithms and th...

  3. A study on transient enhancement for fault diagnosis based on an active noise control system

    Tian, X.; Gu, Fengshou; Zhen, Dong; Tran, Tung; Ball, Andrew

    2012-01-01

    Active noise control (ANC) is a more effective technique used for acoustic noise cancelation in comparison with passive approaches which are difficult and expensive to implement, especially for cancelling the noise in the low frequency range. In the ANC system, an anti-noise signal is introduced to suppress the primary noise to produce a residual which is used for updating the adaptive filter coefficients. In this paper, a method of transient content enhancement for fault detection and diagno...

  4. Solar noise storms

    Elgaroy, E O

    2013-01-01

    Solar Noise Storms examines the properties and features of solar noise storm phenomenon. The book also presents some theories that can be used to gain a better understanding of the phenomenon. The coverage of the text includes topics that cover the features and behavior of noise storms, such as the observable features of noise storms; the relationship between noise storms and the observable features on the sun; and ordered behavior of storm bursts in the time-frequency plane. The book also covers the spectrum, polarization, and directivity of noise storms. The text will be of great use to astr

  5. An Overview of the Adaptive Robust DFT

    Djurović Igor

    2010-01-01

    Full Text Available Abstract This paper overviews basic principles and applications of the robust DFT (RDFT approach, which is used for robust processing of frequency-modulated (FM signals embedded in non-Gaussian heavy-tailed noise. In particular, we concentrate on the spectral analysis and filtering of signals corrupted by impulsive distortions using adaptive and nonadaptive robust estimators. Several adaptive estimators of location parameter are considered, and it is shown that their application is preferable with respect to non-adaptive counterparts. This fact is demonstrated by efficiency comparison of adaptive and nonadaptive RDFT methods for different noise environments.

  6. Noise reduction technologies implemented in head-worn preprocessors for improving cochlear implant performance in reverberant noise fields.

    Chung, King; Nelson, Lance; Teske, Melissa

    2012-09-01

    The purpose of this study was to investigate whether a multichannel adaptive directional microphone and a modulation-based noise reduction algorithm could enhance cochlear implant performance in reverberant noise fields. A hearing aid was modified to output electrical signals (ePreprocessor) and a cochlear implant speech processor was modified to receive electrical signals (eProcessor). The ePreprocessor was programmed to flat frequency response and linear amplification. Cochlear implant listeners wore the ePreprocessor-eProcessor system in three reverberant noise fields: 1) one noise source with variable locations; 2) three noise sources with variable locations; and 3) eight evenly spaced noise sources from 0° to 360°. Listeners' speech recognition scores were tested when the ePreprocessor was programmed to omnidirectional microphone (OMNI), omnidirectional microphone plus noise reduction algorithm (OMNI + NR), and adaptive directional microphone plus noise reduction algorithm (ADM + NR). They were also tested with their own cochlear implant speech processor (CI_OMNI) in the three noise fields. Additionally, listeners rated overall sound quality preferences on recordings made in the noise fields. Results indicated that ADM+NR produced the highest speech recognition scores and the most preferable rating in all noise fields. Factors requiring attention in the hearing aid-cochlear implant integration process are discussed. PMID:22750449

  7. NASA propeller noise research

    Greene, G. C.

    1980-01-01

    The research in propeller noise prediction, noise/performance optimization, and interior reduction is described. Selected results are presented to illustrate the status of the technology and the direction of future research.

  8. [Assessment of noise exposure in sheep].

    Hauser, R; Wechsler, B

    2013-02-01

    The behaviour of sheep was recorded as a reaction to the sound pressure levels caused by shooting with heavy machine guns. The reactions varied in intensity depending on the distance of the source of the noise from the fold. In the case of salvoes that were fired in the immediate vicinity of the fold and were associated with sound pressure levels higher than 120 dB (LCpeak), the sheep reacted with marked fright reactions, and no adaptation to the shooting noise was observed. It is concluded that the tolerable maximum noise level for sheep with this kind of noise source is likely to be less than 120 dB (LCpeak). PMID:23385071

  9. Yesterday's noise - today's signal

    Noise signals can yield information on both the dynamic and steady-state performance of a system. Application of signal noise presents many challenges which can be met successfully, resulting in significant benefits. The concept and characteristics of signal noise and the benefits that can be obtained through use of signal noise are discussed. Results from practical applications to nuclear systems are given with emphasis on applications to the Gentilly-1 reactor

  10. Filtering Solid Gabor Noise

    Lagae, Ares; Drettakis, George

    2011-01-01

    Solid noise is a fundamental tool in computer graphics. Surprisingly, no existing noise function supports both high-quality anti-aliasing and continuity across sharp edges. In this paper we show that a slicing approach is required to preserve continuity across sharp edges, and we present a new noise function that supports anisotropic filtering of sliced solid noise. This is made possible by individually filtering the slices of Gabor kernels, which requires the proper treatment of phase. This ...

  11. Coupling Reduces Noise

    Kia, Behnam; Kia, Sarvenaz; Lindner, John. F.; Sinha, Sudeshna; Ditto, William L.

    2014-01-01

    We demonstrate how coupling nonlinear dynamical systems can reduce the effects of noise. For simplicity we investigate noisy coupled map lattices. Noise from different lattice nodes can diffuse across the lattice and lower the noise level of individual nodes. We develop a theoretical model that explains this observed noise evolution and show how the coupled dynamics can naturally function as an averaging filter. Our numerical simulations are in excellent agreement with the model predictions.

  12. Nonlinear noise cancellation

    Strauch, Paul E

    1997-01-01

    Noise or interference is often assumed to be a random process. Conventional linear filtering, control or prediction techniques are used to cancel or reduce the noise. However, some noise processes have been shown to be nonlinear and deterministic. These nonlinear deterministic noise processes appear to be random when analysed with second order statistics. As nonlinear processes are widespread in nature it may be beneficial to exploit the coherence of the nonlinear deterministic no...

  13. Noise in electromigrated nanojunctions

    Wheeler, P. J.; Chen, Ruoyu; Natelson, D.

    2013-01-01

    Noise measurements are a probe beyond simple electronic transport that can reveal additional information about electronic correlations and inelastic processes. Here we report noise measurements in individual electromigrated nanojunctions, examining the evolution from the many channel regime to the tunneling regime, using a radio frequency technique. While we generally observe the dependence of noise on bias expected for shot noise, in approximately 12% of junction configurations we find discr...

  14. Noise and Neuronal Heterogeneity

    Barber, Michael J.; Ristig, Manfred L.

    2010-01-01

    We consider signal transaction in a simple neuronal model featuring intrinsic noise. The presence of noise limits the precision of neural responses and impacts the quality of neural signal transduction. We assess the signal transduction quality in relation to the level of noise, and show it to be maximized by a non-zero level of noise, analogous to the stochastic resonance effect. The quality enhancement occurs for a finite range of stimuli to a single neuron; we show how to construct network...

  15. Noise in mesoscopic physics

    Martin, Thierry

    2005-01-01

    This is a course on noise which covers some of the scattering theory for normal metals, Hanbury Brown and Twiss analogs for noise correlations with electrons, noise correlations in superconducting/normal metal junctions. Entanglement in such NS systems is described with a criterion for violating Bell inegalities. The last section is devoted to the perturbative derivation of noise in a particular one dimensional correlated electron system (Luttinger liquid): edge states in the fractional quant...

  16. Characteristics of USB noise

    Gibson, J. S.; Searle, N.

    1976-01-01

    An extensive series of noise measurements, for a variety of geometric and operational parameters, was made on models of upper surface blowing (USB) powered lift systems. The data obtained were analyzed and the effects and trends of parametric variation defined. The behavior and nature of USB noise and the design of USB systems with low noise characteristics is examined.

  17. Noise at the Interface

    Prior, Andrew

    2011-01-01

    The notion of noise occupies a contested territory, in which it is framed as pollution and detritus even as it makes its opposite a possibility - noise is always defined in opposition to something else, even if this ‘other’ is not quite clear. This paper explores noise in the context of ‘the...

  18. Phylogenetic perspectives on noise-induced fear and annoyance

    Bowles, Ann

    2003-04-01

    Negative human responses to noise are typically interpreted in terms of human psychological, cognitive, or social processes. However, it may be useful to frame hypotheses about human responses in terms of evolutionary history, during which negative responses have been part of a suite of adaptions to a variable sound environment. By comparing the responses of a range of nonhuman animals to various types of noise, it is possible to develop hypotheses about the ecology of human responses. Examples of noise-related phenomena that could be explained usefully from this perspective include the Schulz curve, noise-induced physical stress, acute fear responses induced by transient noise, and the relationship between temperament and noise-induced annoyance. Responses of animals from a range of taxa will be described and their behavior interpreted in terms of their life-history strategies. With this perspective, some testable hypotheses about noise-induced fear and annoyance will be suggested.

  19. Report on research of calculus fragmentation by HIFU-induced cavitation in Tsinghua University: 1. Effects of tissue-mimicking phantom

    Study of the acoustic attenuation through human tissues was carried out, in order to accurately evaluate the damaging power of the generated cavitation cloud. Tissue phantom was made, with acoustic properties (acoustic speed and acoustic attenuation factor) similar to human tissues. Preliminary results show that, with the increase of intensity and acting time of the HIFU acoustic waves, the depths of the craters increase rapidly, while the radii of the craters increase mildly. Mass loss of the artificial stones in phantom is less than in water (about 50%), indicating considerable energy dissipation in tissues.

  20. Classical noise, quantum noise and secure communication

    Tannous, C.; Langlois, J.

    2016-01-01

    Secure communication based on message encryption might be performed by combining the message with controlled noise (called pseudo-noise) as performed in spread-spectrum communication used presently in Wi-Fi and smartphone telecommunication systems. Quantum communication based on entanglement is another route for securing communications as demonstrated by several important experiments described in this work. The central role played by the photon in unifying the description of classical and quantum noise as major ingredients of secure communication systems is highlighted and described on the basis of the classical and quantum fluctuation dissipation theorems.

  1. Influence of Internal and External Noise on Spontaneous Visuomotor Synchronization.

    Varlet, Manuel; Schmidt, R C; Richardson, Michael J

    2016-01-01

    Historically, movement noise or variability is considered to be an undesirable property of biological motor systems. In particular, noise is typically assumed to degrade the emergence and stability of rhythmic motor synchronization. Recently, however, it has been suggested that small levels of noise might actually improve the functioning of motor systems and facilitate their adaptation to environmental events. Here, the authors investigated whether noise can facilitate spontaneous rhythmic visuomotor synchronization. They examined the influence of internal noise in the rhythmic limb movements of participants and external noise in the movement of an oscillating visual stimulus on the occurrence of spontaneous synchronization. By indexing the natural frequency variability of participants and manipulating the frequency variability of the visual stimulus, the authors demonstrated that both internal and external noise degrade synchronization when the participants' and stimulus movement frequencies are similar, but can actually facilitate synchronization when the frequencies are different. Furthermore, the two kinds of noise interact with each other. Internal noise facilitates synchronization only when external noise is minimal and vice versa. Too much internal and external noise together degrades synchronization. These findings open new perspectives for better understanding the role of noise in human rhythmic coordination. PMID:26046969

  2. Adaptive Lighting

    Petersen, Kjell Yngve; Søndergaard, Karin; Kongshaug, Jesper

    2015-01-01

    Adaptive LightingAdaptive lighting is based on a partial automation of the possibilities to adjust the colour tone and brightness levels of light in order to adapt to people’s needs and desires. IT support is key to the technical developments that afford adaptive control systems. The possibilities offered by adaptive lighting control are created by the ways that the system components, the network and data flow can be coordinated through software so that the dynamic variations are controlled i...

  3. Modified Adaptive Weighted Averaging Filtering Algorithm for Noisy Image Sequences

    LI Weifeng; YU Daoyin; CHEN Xiaodong

    2007-01-01

    In order to avoid the influence of noise variance on the filtering performances, a modified adaptive weighted averaging (MAWA) filtering algorithm is proposed for noisy image sequences. Based upon adaptive weighted averaging pixel values in consecutive frames, this algorithm achieves the filtering goal by assigning smaller weights to the pixels with inappropriate estimated motion trajectory for noise. It only utilizes the intensity of pixels to suppress noise and accordingly is independent of noise variance. To evaluate the performance of the proposed filtering algorithm, its mean square error and percentage of preserved edge points were compared with those of traditional adaptive weighted averaging and non-adaptive mean filtering algorithms under different noise variances. Relevant results show that the MAWA filtering algorithm can preserve image structures and edges under motion after attenuating noise, and thus may be used in image sequence filtering.

  4. Low-noise amplifier

    V. B. Gulkov; A. S. Makarenko

    2012-01-01

    The mixture of signal and noise processing device is considered in this article. It contains two channels: the main channel (MC) contains the mixture of signal and noise, and compensation channel (CC) that extracts just a noise from the mixture. The feature of the processing circuit is that the mixture samples are formed by short impulses at the moments of passing signal through zero. Further antiphase noise is set in the channels, adder by which the noise is removed from mixture is set on th...

  5. Direct-reading dial for noise temperature and noise resistance

    Diamond, J.M.

    1967-01-01

    An attenuator arrangement for a noise generator is described. The scheme permits direct reading of both noise resistance and noise temperature¿the latter with a choice of source resistance.......An attenuator arrangement for a noise generator is described. The scheme permits direct reading of both noise resistance and noise temperature¿the latter with a choice of source resistance....

  6. Low-noise amplifier

    V. B. Gulkov

    2012-11-01

    Full Text Available The mixture of signal and noise processing device is considered in this article. It contains two channels: the main channel (MC contains the mixture of signal and noise, and compensation channel (CC that extracts just a noise from the mixture. The feature of the processing circuit is that the mixture samples are formed by short impulses at the moments of passing signal through zero. Further antiphase noise is set in the channels, adder by which the noise is removed from mixture is set on the cannels output. Study of the described device was carried out for simulated AM signal and white Gaussian noise in simulation environment Matlab. The results are shown, that device reduces noise by 16 dB of power.

  7. Active3 noise reduction

    Noise reduction is a problem being encountered in a variety of applications, such as environmental noise cancellation, signal recovery and separation. Passive noise reduction is done with the help of absorbers. Active noise reduction includes the transmission of phase inverted signals for the cancellation. This paper is about a threefold active approach to noise reduction. It includes the separation of a combined source, which consists of both a noise and a signal part. With the help of interaction with the source by scanning it and recording its response, modeling as a nonlinear dynamical system is achieved. The analysis includes phase space analysis and global radial basis functions as tools for the prediction used in a subsequent cancellation procedure. Examples are given which include noise reduction of speech. copyright 1996 American Institute of Physics

  8. Nuclear Spin Noise and STM Noise Spectroscopy

    Balatsky, A. V.; Fransson, J.; Mozyrsky, D.; Manassen, Yishay

    2006-01-01

    We consider fluctuations of the electronic spin due to coupling to nuclear spin. Noise spectroscopy of an electronic spin can be revealed in the Scanning Tunnelling Microscope (STM). We argue that the noise spectroscopy of electronic spin can reveal the nuclear spin dynamics due to hyperfine coupling. Tunnelling current develops satellites of the main lines at Larmor frequency and at zero frequency due to hyperfine coupling. We also address the role of the rf field that is at or near the reso...

  9. Expectation-maximization (EM) Algorithm Based on IMM Filtering with Adaptive Noise Covariance%基于期望最大化算法的自适应噪声交互多模型滤波

    雷明; 韩崇昭

    2006-01-01

    A novel method under the interactive multiple model (IMM) filtering framework is presented in this paper, in which the expectation-maximization (EM) algorithm is used to identify the process noise covariance Q online. For the existing IMM filtering theory, the matrix Q is determined by means of design experience, but Q is actually changed with the state of the maneuvering target.Meanwhile it is severely influenced by the environment around the target, i.e., it is a variable of time. Therefore, the experiential covariance Q can not represent the influence of state noise in the maneuvering process exactly. Firstly, it is assumed that the evolved state and the initial conditions of the system can be modeled by using Gaussian distribution, although the dynamic system is of a nonlinear measurement equation, and furthermore the EM algorithm based on IMM filtering with the Q identification online is proposed. Secondly, the truncated error analysis is performed. Finally,the Monte Carlo simulation results are given to show that the proposed algorithm outperforms the existing algorithms and the tracking precision for the maneuvering targets is improved efficiently.

  10. Noise from wind turbines

    Fegeant, Olivier [Royal Inst. of Tech., Stockholm (Sweden). Dept. of Building Sciences

    2002-02-01

    A rapid growth of installed wind power capacity is expected in the next few years. However, the siting of wind turbines on a large scale raises concerns about their environmental impact, notably with respect to noise. To this end, variable speed wind turbines offer a promising solution for applications in densely populated areas like the European countries, as this design would enable an efficient utilisation of the masking effect due to ambient noise. In rural and recreational areas where wind turbines are sited, the ambient noise originates from the action of wind on the vegetation and about the listener's ear (pseudo-noise). It shows a wind speed dependence similar to that of the noise from a variable speed wind turbine and can therefore mask the latter for a wide range of conditions. However, a problem inherent to the design of these machines is their proclivity to pure tone generation, because of the enhanced difficulty of avoiding structural resonances in the mechanical parts. Pure tones are deemed highly annoying and are severely regulated by most noise policies. In relation to this problem, the vibration transmission of structure-borne sound to the tower of the turbine is investigated, in particular when the tower is stiffened at its upper end. Furthermore, since noise annoyance due to wind turbine is mostly a masking issue, the wind-related sources of ambient noise are studied and their masking potentials assessed. With this aim, prediction models for wind-induced vegetation noise and pseudo-noise have been developed. Finally, closely related to the effect of masking, is the difficulty, regularly encountered by local authorities and wind farm developers, to measure noise immission from wind turbines. A new measurement technique has thus been developed in the course of this work. Through improving the signal-to-noise ratio between wind turbine noise and ambient noise, the new technique yields more accurate measurement results.

  11. A Comparative Study of Removal Noise from Remote Sensing Image

    Al-amri, Salem Saleh; Khamitkar, S D

    2010-01-01

    This paper attempts to undertake the study of three types of noise such as Salt and Pepper (SPN), Random variation Impulse Noise (RVIN), Speckle (SPKN). Different noise densities have been removed between 10% to 60% by using five types of filters as Mean Filter (MF), Adaptive Wiener Filter (AWF), Gaussian Filter (GF), Standard Median Filter (SMF) and Adaptive Median Filter (AMF). The same is applied to the Saturn remote sensing image and they are compared with one another. The comparative study is conducted with the help of Mean Square Errors (MSE) and Peak-Signal to Noise Ratio (PSNR). So as to choose the base method for removal of noise from remote sensing image.

  12. Perception Neural Networks for Active Noise Control Systems

    Wang Xiaoli

    2012-11-01

    Full Text Available In a response to a growing demand for environments of 70dB or less noise levels, many industrial sectors have focused with some form of noise control system. Active noise control (ANC has proven to be the most effective technology. This paper mainly investigates application of neural network on self-adaptation system in active noise control (ANC. An active silencing control system is made which adopts a motional feedback loudspeaker as not a noise controlling source but a detecting sensor. The working fundamentals and the characteristics of the motional feedback loudspeaker are analyzed in detail. By analyzing each acoustical path, identification based adaptive linear neural network is built. This kind of identifying method can be achieved conveniently. The estimated result of each sound channel matches well with its real sound character, respectively.

  13. A Comparative Study of Removal Noise from Remote Sensing Image

    Santosh Khamitkar

    2010-01-01

    Full Text Available This paper attempts to undertake the study of three types of noise such as Salt and Pepper (SPN, Random variation Impulse Noise (RVIN, Speckle (SPKN. Different noise densities have been removed between 10% to 60% by using five types of filters as Mean Filter (MF, Adaptive Wiener Filter (AWF, Gaussian Filter (GF, Standard Median Filter (SMF and Adaptive Median Filter (AMF. The same is applied to the Saturn remote sensing image and they are compared with one another. The comparative study is conducted with the help of Mean Square Errors (MSE and Peak-Signal to Noise Ratio (PSNR. So as to choose the base method for removal of noise from remote sensing image.

  14. A normalized data-reusing least-mean-square algorithm of noise cancellation for magnetocardiography

    Kong Xiang-Yan; Wang Hui-Wu; Tian Ye; Huang Xu-Guang; Zhang Li-Hua; Ren Yu-Feng; Chen Geng-Hua; Yang Qian-Sheng

    2004-01-01

    An adaptive filter based on Data-Reusing Least-Mean-Square algorithm has been proposed and applied in magnetocardiography (MCG) to suppress ambient noise. Numerical simulation studies indicate that the adaptive filter is a powerful noise suppresser for correlated interferences, especially for those with amplitude changing and time delay.Also the filter has a wide frequency bandwidth. With this filter, the signal-to-noise ratio of an MCG is improved to the intrinsic noise level. The periodic average method for further improvement of the noise level in MCG is also discussed.

  15. The Detection and Exclusion of the Prostate Neuro-Vascular Bundle (NVB) in Automated HIFU Treatment Planning Using a Pulsed-Wave Doppler Ultrasound System

    Chen, Wohsing; Carlson, Roy F.; Fedewa, Russell; Seip, Ralf; Sanghvi, Narendra T.; Dines, Kris A.; Pfile, Richard; Penna, Michael A.; Gardner, Thomas A.

    2005-03-01

    Men with prostate cancer are likely to develop impotence after prostate cancer therapy if the treatment damages the neuro-vascular bundles (NVB). The NVB are generally located at the periphery of the prostate gland. To preserve the NVB, a Doppler system is used to detect and localize the associated blood vessels. This information is used during the therapy planning procedure to avoid treatment surrounding the blood vessel areas. The Sonablate®500 (Focus Surgery, Inc.) image-guided HIFU device is enhanced with a pulse-wave multi-gate Doppler system that uses the current imaging transducer and mechanical scanner to acquire Doppler data. Doppler detection is executed after the regular B-mode images are acquired from the base to the apex of the prostate using parallel sector scans. The results are stored and rendered in 3-D display, registered with additional models generated for the capsule, urethra, and rectal wall, and the B-mode data and treatment plan itself. The display of the blood flow can be in 2-D color overlaid on the B-mode image or in 3-D color structure. Based on this 3-D model, the HIFU treatment planning can be executed in automated or manual mode by the physician to remove originally defined treatment zones that overlap with the NVB (for preservation of NVB). The results of the NVB detection in animal experiments, and the 3-D modeling and data registration of the prostate will be presented.

  16. Desired Accuracy Estimation of Noise Function from ECG Signal by Fuzzy Approach

    Vahabi, Zahra; Kermani, Saeed

    2012-01-01

    Unknown noise and artifacts present in medical signals with non-linear fuzzy filter will be estimated and then removed. An adaptive neuro-fuzzy interference system which has a non-linear structure presented for the noise function prediction by before Samples. This paper is about a neuro-fuzzy method to estimate unknown noise of Electrocardiogram signal. Adaptive neural combined with Fuzzy System to construct a fuzzy Predictor. For this system setting parameters such as the number of Membershi...

  17. Detection and Cancellation of Jamming Signal Noise Using Digital Filters for Radar Applications

    Ch. Anoosha; Ch. Kusmakumari; Nirmala, M.

    2013-01-01

    This paper considers the problem of detecting and classifying a radar target signal from a jamming signal produced from a target jammer source. Jamming is intentional emission of radio frequency signals to interfere with the operation of a radar by saturating its receiver with noise or false information. In order to distill the features of radar echo-signal affected by strong jamming noise, the adaptive filters are used to remove the noise and recover the radar echo-signal. An Adaptive filter...

  18. Traffic Noise Propagating from Vibration of Railway Wagon

    Shao-Yi Hsia

    2013-01-01

    Full Text Available Traffic noise has become a serious environmental hazard as more cars are purchased and driven. To help objectively and subjectively reduce perceived noise load, methods to analyze traffic noise offer an important means of creating a design to reduce noise output from main sources and transmission routes. Acoustic analysis using BEASY and dynamic analysis using ANSYS are conducted to forecast noise at a distance of 15 m from a railway wagon travelling at 100 km/h. This noise is based on structural vibration only and it excludes other noise sources from the railway wagon. The simulation results demonstrate that the overall noise at 15 m from a railway wagon car is 85.1 dB(L from linear energy weighting calculation and 72.9 dB(A from the A-weighting calculation. In this study, noise level propagating from vibration of the railway wagon is measured or calculated using A-weighting filter to simulate the frequency response of the human ear. The study results can be useful to factories, companies, or organizations and can provide an important resource and help reduce traffic noise. This can be achieved by predetermining the test location and structure configuration and adapting local planning and thus preventing excessive traffic noise in residential areas.

  19. Mitigation of calorimeter noise.

    Santi, P. A. (Peter A.); Bracken, D. S. (David S.); Smith, M. K. (Morag K.)

    2004-01-01

    One of the main factors that limit the sensitivity of calorimeters is the noise in the calorimeter response. A previous study into the sources of noise in a Wheatstone bridge calorimeter used by Department of Energy (DOE) facilities has shown that the control system for maintaining the water bath at a constant temperature was an important contributor to the noise in the system. In order to minimize the contribution that the control system makes to the noise in the calorimeter response, a new control system for the calorimeter has been developed. An experimental and analytical study has been performed to determine the effectiveness of this new control system in reducing the response noise in a Wheatstone bridge calorimeter. The results of this study are presented along with their implications for future work in minimizing the equilibrium noise of calorimeters.

  20. Noise and public health.

    Lipscomb, D M; Roettger, R W

    1976-01-01

    Environmental noise has increased to the point that it affects large numbers of people. The most consistently demonstrated health effect of exposure to noise is hearing impairment. Other effects, such as stress reaction, irritability, fatigue and disturbances to physiologic function have been seen in laboratory research but are highly individualized and restricted to such specific populations as industrial workers. Rising background sound levels in communities due to increased traffic flow, industralization, work saving machinery, and other noise sources have caused community noise levels to become dangerously high. This factor is complicated by exposure to high sound level recreational activities with greater frequency and for longer periods. Recognizing the existence of the problem, governmental agencies have begun to identify the scope of the problem, to designate standards and regulations controlling noise sources, and to regulate allowable noise exposure for workers. PMID:10297834

  1. Thoughts out of noise

    We study the effects of additive Gaussian noise on the behaviour of a simple spatially extended system, which is locally modelled by a nonlinear two-dimensional iterated map describing neuronal dynamics. In particular, we focus on the ability of noise to induce spatially ordered patterns, i.e. the so-called noise-induced pattern formation. For intermediate noise intensities, the spatially extended system exhibits ordered circular waves, thereby clearly manifesting the constructive role of random perturbations. The emergence of observed noise-induced patterns is explained with simple arguments that are obtained by analysing the typical spatial scale of patterns evoked by various diffusion coefficients. Since discrete-time systems are straightforward to implement and require modest computational capabilities, the present study describes one of the most fascinating and visually compelling examples of noise-induced self-organization in nonlinear systems in an accessible way for graduate or even advanced undergraduate students attending a nonlinear dynamics course

  2. Adaptive skills

    Staša Stropnik; Jana Kodrič

    2013-01-01

    Adaptive skills are defined as a collection of conceptual, social and practical skills that are learned by people in order to function in their everyday lives. They include an individual's ability to adapt to and manage her or his surroundings to effectively function and meet social or community expectations. Good adaptive skills promote individual's independence in different environments, whereas poorly developed adaptive skills are connected to individual's dependency and with g...

  3. Reliability, synchrony and noise

    Ermentrout, G. Bard; Galán, Roberto F; Urban, Nathaniel N.

    2008-01-01

    The brain is noisy. Neurons receive tens of thousands of highly fluctuating inputs and generate spike trains that appear highly irregular. Much of this activity is spontaneous—uncoupled to overt stimuli or motor outputs—leading to questions about the functional impact of this noise. Although noise is most often thought of as disrupting patterned activity and interfering with the encoding of stimuli, recent theoretical and experimental work has shown that noise can play a constructive role—lea...

  4. Acceptable noise level

    Olsen, Steen Østergaard; Nielsen, Lars Holme; Lantz, Johannes;

    2012-01-01

    The acceptable noise level (ANL) is used to quantify the amount of background noise that subjects can accept while listening to speech, and is suggested for prediction of individual hearing-aid use. The aim of this study was to assess the repeatability of the ANL measured in normal-hearing subjects...... using running Danish and non-semantic speech materials as stimuli and modulated speech-spectrum and multi-talker babble noises as competing stimuli....

  5. Word Identification in Noise

    Pisoni, David B.

    1996-01-01

    Speech intelligibility has traditionally been measured by presenting words mixed in noise to listeners for identification at several different signal-to-noise ratios. The words are produced in isolation or in sentence contexts where the predictability of specific items can be varied. Psychometric functions are typically obtained relating signal-to-noise ratio to percent correct recognition. Error analyses are often carried out by examining response confusions to construct similarity spaces fo...

  6. Multidimensional Speckle Noise Model

    Fàbregas Xavier; López-Martínez Carlos; Pottier Eric

    2005-01-01

    One of the main problems of SAR imagery is the presence of speckle noise, originated by the inherent coherent nature of this type of systems. For one-dimensional SAR systems it has been demonstrated that speckle can be considered as a multiplicative noise term. Nevertheless, this simple model cannot be exported when multidimensional SAR imagery is addressed. This paper is devoted to present the latest advances into the definition of a multidimensional speckle noise model which does not depen...

  7. Nuclear spin noise imaging

    Müller, Norbert; Jerschow, Alexej

    2006-01-01

    NMR images were obtained from the proton spin noise signals of a water-containing phantom, which was placed in the highly tuned, low-noise resonant circuit of a cryogenically cooled NMR probe in the presence of systematically varied magnetic field gradients. The spatially resolved proton spin density was obtained from the raw signal by a modified projection–reconstruction protocol. Although spin noise imaging is inherently less sensitive than conventional magnetic resonance imaging, it afford...

  8. Aircrafts' taxi noise emission

    Asensio Rivera, César; Pagán Muñoz, Raúl; López Navarro, Juan Manuel

    2008-01-01

    During planning stages, when noisy activity has not been implanted or while evaluating operation changes, it is necessary to find an environmental noise mapping prediction tool for future scenarios. When an activity is already implanted, it is possible to measure noise emissions, but this is expensive, so prediction tools can also be useful. Because of these reasons, for the last 10 years, as a response to the increasing concern for noise pollution in developed countries, several simulation m...

  9. Nonlinear Adaptive Filters based on Particle Swarm Optimization

    Faten BEN ARFIA; Ben Messaoud, Mohamed; Abid, Mohamed

    2009-01-01

    This paper presents a particle swarm optimization (PSO) algorithm to adjust the parameters of the nonlinear filter and to make this type of the filters more powerful for the elimination of the Gaussian noise and also the impulse noise. In this paper we apply the particle swarm optimization to the rational filters and we completed this work with the comparison between our results and other adaptive nonlinear filters like the LMS adaptive median filters and the no-adaptive rational filter.

  10. Landing gear noise attenuation

    Moe, Jeffrey W. (Inventor); Whitmire, Julia (Inventor); Kwan, Hwa-Wan (Inventor); Abeysinghe, Amal (Inventor)

    2011-01-01

    A landing gear noise attenuator mitigates noise generated by airframe deployable landing gear. The noise attenuator can have a first position when the landing gear is in its deployed or down position, and a second position when the landing gear is in its up or stowed position. The noise attenuator may be an inflatable fairing that does not compromise limited space constraints associated with landing gear retraction and stowage. A truck fairing mounted under a truck beam can have a compliant edge to allow for non-destructive impingement of a deflected fire during certain conditions.

  11. Noise from wind farms

    Noise measurements has been carried out at increasing distances from wind farms with small wind turbines (75-110 kW). Measurements were performed for different layout of the wind park (a network or a line of turbines). Prediction of the noise levels according to the Danish or the IEA method resulted in an overestimation of the total level by up to 8 dB. In order to explain these discrepancies further investigations have included: measurements of the source strength for 4 different samples of the wind turbines, more elaborate directivity measurement, a repetition of the noise measurements, a pilot study of noise propagation under windy conditions. The investigations showed that the individual differences in source strength was smaller than ±1 dB and that the directivity in directions ±60 deg. relative to downwind was in the order of -1 dB to -2dB in most of the frequency range. Consequently, both hypotheses failed to explain the observed differences between measured and predicted noise levels. New noise measurements and predictions (taking the actual source strength and directivity into account) confirmed the original findings, that noise levels are overestimated by 1 - 6 dB. Noise propagation investigations using a powerful loudspeaker showed that the effect of the terrain on the noise propagation is strongly dependent on frequency. This dependency was a function of the wind speed and in qualitative agreement with a theoretical sound propagation model. (au)

  12. Noise upon the Sinusoids

    Jensen, Karl Kristoffer

    2005-01-01

    Sinusoids are used for making harmonic and other sounds. In order to having life in the sounds and adding a wide variety of noises, irregularities are inserted in the frequency and amplitudes. A simple and intuitive noise model is presented, consisting of a low-pass filtered noise, and having...... control for strength and bandwidth. The noise is added on the frequency and amplitudes of the sinusoids, and the resulting irregularity’s (jitter and shimmer) bandwidth is derived. This, together with an overview of investigation methods of the jitter and shimmer results in an analysis of the necessary...

  13. Partially informed noise traders

    Aase, Knut K.; Bjuland, Terje; Øksendal, Bernt

    2012-01-01

    The single auction equilibrium of Kyle’s (1985) is studied, in which noise traders may be partially informed, or alternatively they can be manipulated. Unlike Kyle’s assumption that the quantity traded by the noise traders is independent of the asset value, we assume that the noise traders are able to correlate their trade with the true price. This has several implications for the equilibrium, one being that the informed trader’s expected profits decrease as the noise traders’ ability to corr...

  14. Noise upon the sinusoids

    Jensen, Karl Kristoffer

    2005-01-01

    Sinusoids are used for making harmonic and other Sounds. In order to having life in the sounds and adding a wide variety of noises, irregularities are inserted in the frequency and amplitudes. A simple and intuitive noise model is presented, consisting of a low-pass filtered noise, and having...... control for strength and bandwidth. The noise is added on the frequency and amplitudes of the sinusoids, and the resulting irregularity's (jitter and shimmer) bandwidth is derived. This, together with an overview of investigation methods of the jitter and shimmer results in an analysis of the necessary...

  15. On 1/f Noise

    Li, Ming; Zhao, Wei

    2012-01-01

    Due to the fact that 1/f noise gains the increasing interests in the field of biomedical signal processing and living systems, we present this introductive survey that may suffice to exhibit the elementary and the particularities of 1/f noise in comparison with conventional random functions. Three theorems are given for highlighting the particularities of 1/f noise. The first says that a random function with long-range dependence (LRD) is a 1/f noise. The secondindicates that a heavy-tailed r...

  16. Noise through Quantum Pumps

    Polianski, M. L.; Vavilov, M. G.; Brouwer, P.W.

    2002-01-01

    We study the current noise through an unbiased quantum electron pump and its mesoscopic fluctuations for arbitrary temperatures and beyond the bilinear response. In the bilinear regime, we find the full distributions of the noise power and the current-to-noise ratio for a chaotic quantum dots with single-channel and many-channel ballistic point contacts. For a dot with many-channel point contacts we also calculate the ensemble-averaged noise at arbitrary temperature and pumping strength. In t...

  17. Adaptive Endpoint Detection Based on Subband Speech

    张文军; 谢剑英

    2003-01-01

    An adaptive endpoint detection algorithm based on band energy and adaptive smoothing algorithm is described.This algorithm utilizes the capability of adaptive smoothing algorithm that intensifies the discontinuity between local areas. The band energy features are selected because of their usefulness in detecting high energy regions (in the incoming signal) and making the distinction between speech and noise. Heuristic "edge-focusing" is used to endpoint detection to save the time in iteration.

  18. Adaptive processing with signal contaminated training samples

    Besson, Olivier; Bidon, Stéphanie

    2013-01-01

    We consider the adaptive beamforming or adaptive detection problem in the case of signal contaminated training samples, i.e., when the latter may contain a signal-like component. Since this results in a significant degradation of the signal to interference and noise ratio at the output of the adaptive filter, we investigate a scheme to jointly detect the contaminated samples and subsequently take this information into account for estimation of the disturbance covariance matrix. Towards this e...

  19. Adaptive Filter in SAR Interferometry Derived DEM

    XU Caijun; WANG Hua; WANG Jianglin; GE Linlin

    2005-01-01

    In this paper, the performance of median filter, elevation dependent adaptive sigma median filter, and directionally dependent adaptive sigma median filter are tested on both InSAR Tandem DEM and simulated high-level noisy DEM. Through the comparison, the directionally dependent adaptive sigma median filter is proved to be the most effective one not only in the noise removing but also in the boundary preserve.

  20. Noise Estimation and Suppression Using Nonlinear Function with A Priori Speech Absence Probability in Speech Enhancement

    Lee, Soojeong; Lee, Gangseong

    2016-01-01

    This paper proposes a noise-biased compensation of minimum statistics (MS) method using a nonlinear function and a priori speech absence probability (SAP) for speech enhancement in highly nonstationary noisy environments. The MS method is a well-known technique for noise power estimation in nonstationary noisy environments; however, it tends to bias noise estimation below that of the true noise level. The proposed method is combined with an adaptive parameter based on a sigmoid function and a...

  1. A new similarity measure for nonlocal filtering in the presence of multiplicative noise

    Teuber, Tanja; Lang, Annika

    2011-01-01

    This paper presents a new similarity measure and nonlocal filters for images corrupted by multiplicative noise. The considered filters are generalizations of the nonlocal means filter of Buades et al., which is known to be well suited for removing additive Gaussian noise. To adapt to different noise models, the patch comparison involved in this filter has first of all to be performed by a suitable noise dependent similarity measure. To this purpose, we start by studying a probabilistic measur...

  2. Adaptive Lighting

    Petersen, Kjell Yngve; Søndergaard, Karin; Kongshaug, Jesper

    2015-01-01

    Adaptive Lighting Adaptive lighting is based on a partial automation of the possibilities to adjust the colour tone and brightness levels of light in order to adapt to people’s needs and desires. IT support is key to the technical developments that afford adaptive control systems. The possibilities...... offered by adaptive lighting control are created by the ways that the system components, the network and data flow can be coordinated through software so that the dynamic variations are controlled in ways that meaningfully adapt according to people’s situations and design intentions. This book discusses...... distributed differently into an architectural body. We also examine what might occur when light is dynamic and able to change colour, intensity and direction, and when it is adaptive and can be brought into interaction with its surroundings. In short, what happens to an architectural space when artificial...

  3. Sounds and Noises. A Position Paper on Noise Pollution.

    Chapman, Thomas L.

    This position paper focuses on noise pollution and the problems and solutions associated with this form of pollution. The paper is divided into the following five sections: Noise and the Ear, Noise Measurement, III Effects of Noise, Acoustics and Action, and Programs and Activities. The first section identifies noise and sound, the beginnings of…

  4. Adaptive antennas and receivers

    Weiner, Melvin M

    2005-01-01

    In our modern age of remote sensing, wireless communication, and the nearly endless list of other antenna-based applications, complex problems require increasingly sophisticated solutions. Conventional antenna systems are no longer suited to high-noise or low-signal applications such as intrusion detection. Detailing highly effective approaches to non-Gaussian weak signal detection, Adaptive Antennas and Receivers provides an authoritative introduction to state-of-the-art research on the modeling, testing, and application of these technologies.Edited by innovative researcher and eminent expert

  5. Low Complexity Expert Dependent Noise Filtration Algorithm

    Sasi Rekha.Sanivarapu

    2012-06-01

    Full Text Available In this paper, a flexible and robust wavelet based image denoising algorithm is proposed, which adapts itself to various and unknown types of noise as well as to the preference of the medical expert: a single tuning parameter is used to balance the preservation of relevant details against the degree of noise reduction. We employ a preliminary coefficient classification technique to empirically estimate the statistical distributions of the coefficients that represent useful image features on the one hand and mainly noise on the other. The proposed algorithm is of low-complexity, both in its implementation and execution time. The results show that its usefulness for denoising and enhancement of the CT, Ultrasound and Magnetic Resonance images

  6. Speckle Noise Reduction in Medical Ultrasound Images

    Faouzi Benzarti

    2012-03-01

    Full Text Available Ultrasound imaging is an incontestable vital tool for diagnosis, it provides in non-invasive manner the internal structure of the body to detect eventually diseases or abnormalities tissues. Unfortunately, the presence of speckle noise in these images affects edges and fine details which limit the contrast resolution and make diagnostic more difficult. In this paper, we propose a denoising approach which combines logarithmic transformation and a non linear diffusion tensor. Since speckle noise is multiplicative and nonwhite process, the logarithmic transformation is a reasonable choice to convert signal-dependent or pure multiplicative noise to an additive one. The key idea from using diffusion tensor is to adapt the flow diffusion towards the local orientation by applying anisotropic diffusion along the coherent structure direction of interesting features in the image. To illustrate the effective performance of our algorithm, we present some experimental results on synthetically and real echographic images.

  7. Acceptable noise level

    Olsen, Steen Østergaard; Nielsen, Lars Holme; Lantz, Johannes;

    2012-01-01

    The acceptable noise level (ANL) is used to quantify the amount of background noise that subjects can accept while listening to speech, and is suggested for prediction of individual hearing-aid use. The aim of this study was to assess the repeatability of the ANL measured in normal-hearing subjects...

  8. Effects of traffic noise

    Gottlob, D.

    1986-02-01

    One of the main sources of noise is road traffic. In 1984 there were over 25 million cars, 1.2 million lorries, 1.3 million motor cycles and 1.6 million mopeds using our roads. Opinion polls showed that 21% of the population felt that they were affected by traffic noise as a nuisance factor. An outline of the effects of this noise on the affected population is given, illustrated by diagrams. Details about noise emissions (drive-past level) of the different types of vehicles in city traffic are stated and the effects of noise described. The author goes into the nuisance effect (noise is not a physical factor, but a psychosocial one), changes in behaviour (ways of speaking, reduction of stress on households in proportion to rising income and higher educational levels) and the consequences for health (the reaction of the body to noise is primarily a consequence of the psychosomatic organisation of ow bodies). In conclusion, the author deals with the subjective efficiency of noise protection measures. (HWJ).

  9. RB reactor noise analysis

    Statistical fluctuations of reactivity represent reactor noise. Analysis of reactor noise enables determining a series of reactor kinetic parameters. Fluctuations of power was measured by ionization chamber placed next to the tank of the RB reactor. The signal was digitized by an analog-digital converter. After calculation of the mean power, 3000 data obtained by sampling were analysed

  10. Noise Pollution, Teachers' Edition.

    O'Donnell, Patrick A.; Lavaroni, Charles W.

    One of three in a series about pollution, this teacher's guide for a unit on noise pollution is designed for use in junior high school grades. It offers suggestions for extending the information and activities contained in the textual material for students. Chapter 1 discusses the problem of noise pollution and involves students in processes of…

  11. EDA noise analysis

    Using orCAD Pspice EDA software, the circuit simulation and the analysis such as transient analysis, noise analysis, temperature analysis, are made for charge-sensitive preamplifier. By calculation and comparison, the result shows circuit noise responses according to the temperature changes. (authors)

  12. MOWER ATTACHMENT NOISE

    Mosdzianowski, G.

    1990-01-01

    The noise produced by grass mowing attachments fitted to small tractors and combining a number of rotary blades with a total cutting width of up to 120 cm was investigated. The paper develops a noise reduction concept based on an analysis of sound sources.

  13. Noise-induced linearisation

    Dykman, Mark; Luchinsky, D. G.; Mannella, R.; McClintock, Peter V. E.; Short, H. E.; Stein, N. D.; Stocks, N. G.

    1994-01-01

    It is found that the response of a nonlinear dynamical system can be linearised, and its frequency dispersion diminished, by the addition of external noise of sufficient intensity. Taking as an example an overdamped bistable system driven by a low-frequency periodic field, this noise-induced linearisation is investigated through analogue electronic experiments. The wider implications are considered.

  14. Mediality is Noise

    Prior, Andrew

    This PhD is concerned with the use of noise as a material within media arts practice, especially in ‘post-digital’ contexts such as glitch electronica, glitch art and uses of old media. It examines the relationship between informational culture and noise, exploring the ways in which the structuring...

  15. Noise from wind turbines

    Denmark has 3200 wind turbines with an installed maximum capacity of 418MW. The most important Danish research projects into wind turbine noise and the main results are listed. These date from 1983. Two comprehensive studies are currently in progress. The first is an analytical and empirical investigation of aerodynamic noise from wind turbine rotors and has so far dealt mainly with tip noise. The measurement method, using a hard board mounted microphone on the ground near the turbine, is described. Four different tip designs have been tested. Some examples of reference sound power level spectra for three of the designs are presented. During the past two years a computerbased data acquisition system has been used for real-time determination of sound power levels. The second study, which has just commenced, is on annoyance from wind turbine noise. It will include noise measurements, masking calculations and a social survey on the perceived nuisance. (UK)

  16. Noise Enhanced Stability

    The noise can stabilize a fluctuating or a periodically driven metastable state in such a way that the system remains in this state for a longer time than in the absence of white noise. This is the noise enhanced stability phenomenon, observed experimentally and numerically in different physical systems. After shortly reviewing all the physical systems where the phenomenon was observed, the theoretical approaches used to explain the effect are presented. Specifically the conditions to observe the effect in systems: (a) with periodical driving force, and (b) with random dichotomous driving force, are discussed. In case (b) we review the analytical results concerning the mean first passage time and the nonlinear relaxation time as a function of the white noise intensity, the parameters of the potential barrier, and of the dichotomous noise. (author)

  17. Noise in coevolving networks.

    Diakonova, Marina; Eguíluz, Víctor M; San Miguel, Maxi

    2015-09-01

    Coupling dynamics of the states of the nodes of a network to the dynamics of the network topology leads to generic absorbing and fragmentation transitions. The coevolving voter model is a typical system that exhibits such transitions at some critical rewiring. We study the robustness of these transitions under two distinct ways of introducing noise. Noise affecting all the nodes destroys the absorbing-fragmentation transition, giving rise in finite-size systems to two regimes: bimodal magnetization and dynamic fragmentation. Noise targeting a fraction of nodes preserves the transitions but introduces shattered fragmentation with its characteristic fraction of isolated nodes and one or two giant components. Both the lack of absorbing state for homogeneous noise and the shift in the absorbing transition to higher rewiring for targeted noise are supported by analytical approximations. PMID:26465524

  18. Noise in Coevolving Networks

    Diakonova, Marina; Miguel, Maxi San

    2014-01-01

    Coupling dynamics of the states of the nodes of a network to the dynamics of the network topology leads to generic absorbing and fragmentation transitions. The coevolving voter model is a typical system that exhibits such transitions at some critical rewiring. We study the robustness of these transitions under two distinct ways of introducing noise. Noise affecting all the nodes destroys the absorbing-fragmentation transition, giving rise in finite-size systems to two regimes: bimodal magnetisation and dynamic fragmentation. Noise Targeting a fraction of nodes preserves the transitions but introduces shattered fragmentation with its characteristic fraction of isolated nodes and one or two giant components. Both the lack of absorbing state for homogenous noise and the shift in the absorbing transition to higher rewiring for targeted noise are supported by analytical approximations.

  19. Application of GIS in Urban Traffic Noise Pollution

    Manouchehr Omidvari

    2010-07-01

    Full Text Available Large urban areas are facing growing problems of noise pollutions. Geospatial Information Systems (GIS can conveniently be adapted to gather, analyze and present noise information. GIS can also be extended to answer to user specific problems through deterministic and statistics models. The objectives of this research were to measure urban traffic noise levels, analyze temporal and spatial dynamics of urban traffic-induced noise pollution in the first districted of Tehran estimate the noise for pollution concentration, assess the results of Federal Highway Administration Traffic Noise Model (FHWA-TNM and Iranian Traffic Noise Predictor (ITNP; and represent them in a GIS environment. Measurements were done at the traffic peak time and also when the traffic was at its minimum, during three successive months. In this study, Leq, L10, L50, L90, Lmax and Lmin were gathered. The results demonstrated that most of commercial and residential regions surrounding the main streets are suffering from sever noise pollution. Processed data, spatial analysis and models are integrated within the framework of ArcGIS software environment, providing adequate tools to address noise issues. The assessment showed that the issue of noise pollution is currently ignored in urban regulations concerning environmental quality.

  20. Noise removal in nuclear medicine images by using multi resolution

    A novel flexible and dynamic algorithm for noise removal in nuclear medicine images is proposed. The images have a very low signal-to-noise ratio and the total number of registered photons is relatively small. The algorithm removes the noise from both the images original spatial domain and from the wavelet transform domain. In the spatial domain it uses both the autocorrelation technique in order to remove the noise that appears in a from of isolated pixels around the objects of interest and the information that each image contains about the signal in its neighbouring images. In the transform domain the wavelet coefficients filtration is carried out with a filter bank which meets the near-perfect reconstruction condition and is adapted to the signal. In addition, the coefficients that correspond to noise and are about to be discarded are selected by using a non uniform threshold which is adapted to the spatial varying noise level. Criteria for selection of an optimal decomposition level for the NM images are defined. In order to suppress the noise, multi resolution characteristics of both the signal and noise are used.(Author)

  1. An Adaptive Unscented Kalman Filtering Algorithm for MEMS/GPS Integrated Navigation Systems

    Jianhua Cheng; Daidai Chen; Rene Jr. Landry; Lin Zhao; Dongxue Guan

    2014-01-01

    MEMS/GPS integrated navigation system has been widely used for land-vehicle navigation. This system exhibits large errors because of its nonlinear model and uncertain noise statistic characteristics. Based on the principles of the adaptive Kalman filtering (AKF) and unscented Kalman filtering (AUKF) algorithms, an adaptive unscented Kalman filtering (AUKF) algorithm is proposed. By using noise statistic estimator, the uncertain noise characteristics could be online estimated to adaptively com...

  2. Adaptive Lighting

    Petersen, Kjell Yngve; Søndergaard, Karin; Kongshaug, Jesper

    2015-01-01

    Adaptive Lighting Adaptive lighting is based on a partial automation of the possibilities to adjust the colour tone and brightness levels of light in order to adapt to people’s needs and desires. IT support is key to the technical developments that afford adaptive control systems. The possibilities...... offered by adaptive lighting control are created by the ways that the system components, the network and data flow can be coordinated through software so that the dynamic variations are controlled in ways that meaningfully adapt according to people’s situations and design intentions. This book discusses...... the investigations of lighting scenarios carried out in two test installations: White Cube and White Box. The test installations are discussed as large-scale experiential instruments. In these test installations we examine what could potentially occur when light using LED technology is integrated and...

  3. Quantum Computers: Noise Propagation and Adversarial Noise Models

    Kalai, Gil

    2009-01-01

    In this paper we consider adversarial noise models that will fail quantum error correction and fault-tolerant quantum computation. We describe known results regarding high-rate noise, sequential computation, and reversible noisy computation. We continue by discussing highly correlated noise and the "boundary," in terms of correlation of errors, of the "threshold theorem." Next, we draw a picture of adversarial forms of noise called (collectively) "detrimental noise." Detrimental noise is mode...

  4. Adaptive skills

    Staša Stropnik

    2013-02-01

    Full Text Available Adaptive skills are defined as a collection of conceptual, social and practical skills that are learned by people in order to function in their everyday lives. They include an individual's ability to adapt to and manage her or his surroundings to effectively function and meet social or community expectations. Good adaptive skills promote individual's independence in different environments, whereas poorly developed adaptive skills are connected to individual's dependency and with greater need for control and help with everyday tasks. Assessment of adaptive skills is often connected to assessment of intellectual disability, due to the reason that the diagnosis of intellectual disability includes lower levels of achievements on standardized tests of intellectual abilities as well as important deficits in adaptive skills. Assessment of adaptive behavior is a part of standard assessment battery with children and adults with different problems, disorders or disabilities that affect their everyday functioning. This contribution also presents psychometric tools most regularly used for assessment of adaptive skills and characteristics of adaptive skills with individual clinical groups.

  5. ADAPT Dataset

    National Aeronautics and Space Administration — Advanced Diagnostics and Prognostics Testbed (ADAPT) Project Lead: Scott Poll Subject Fault diagnosis in electrical power systems Description The Advanced...

  6. Noise and Phase Transitions

    Chen, Zhi; Yu, Clare C.

    2006-03-01

    Noise is present in many physical systems and is often viewed as a nuisance. Yet it can also be a probe of microscopic fluctuations. There have been indications recently that the noise in the resistivity increases in the vicinity of the metal-insulator transition. But what are the characteristics of the noise associated with well-understood first and second order phase transitions? It is well known that critical fluctuations are associated with second order phase transitions, but do these fluctuations lead to enhanced noise? We have addressed these questions using Monte Carlo simulations to study the noise in the 2D Ising model which undergoes a second order phase transition, and in the 5-state Potts model which undergoes a first order phase transition. We monitor these systems as the temperature drops below the critical temperature. At each temperature, after equilibration is established, we obtain the time series of quantities characterizing the properties of the system, i.e., the energy and magnetization per site. We apply different methods, such as the noise power spectrum, the Detrended Fluctuation Analysis (DFA) and the second spectrum of the noise, to analyze the fluctuations in these quantities.

  7. Substation noise screening tool

    Maybee, Nigel; Everton, Pascal [HFP Acoustical Consultants Corp. (Canada)], email: nigel.maybee@hfpacoustical.com; Chow, Vincent [Altalink Management Ltd. (Canada)], email: Vincent.Chow@AltaLink.ca

    2011-07-01

    Alberta noise regulations require energy-related facilities to conduct predictions on sound levels, especially for large and medium noise sources. This is usually done with well-known modelling software, but that can be disadvantageous when assessing the noise impact of smaller noise sources, such as transformer substations. This paper focuses on the development of a spreadsheet substation noise screening tool to assess the noise impact of a small transformer substation with precision and ease-of-use. Three aspects must be considered: transformer sound levels, which can be provided by the manufacturer or extracted from accepted sound level references; sound power calculations, which depend on the substation size and operating regime; and sound propagation calculations, which take into account the distance of the receptor from the substation and sound absorption by the air and ground. Comparison of results obtained with this tool with results generated by standard sound modelling software shows the utility, accuracy and ease-of-use of this screening method for assessing the noise impact of transformer substations.

  8. [The fetus and noise].

    Brezinka, C; Lechner, T; Stephan, K

    1997-01-01

    From 23 weeks of gestation some and from 28 weeks all healthy fetuses are capable of reacting to sound stimulation. The intrauterine acoustic environment is dominated by maternal sounds--heartbeat, breathing, the mother's voice, borborygmi and sounds caused by body movements. Background noise is never below 28 dB and can rise to 84 dB when the mother is singing. Noises that are meant to reach the fetus must be louder than the background noise and must be of low frequency as high frequency sounds are damped by maternal tissue. Vibroacoustic stimulation tests (VAST) have become popular in pregnancy surveillance over the last 20 years, mostly using an artificial larynx. Advantages and problems of the various VAST protocols in fetal monitoring are discussed in the light of animal experiments and clinical studies. Health legislation laws in most countries forbid pregnant women to work in surroundings with a high noise level (80 dB continuous noise and/or rapid impulse noise changes of 40 dB). Whereas regulations for pregnant women are easy to enforce in industry, pregnant women employed in discos or performing as musicians spend most of their working day exposed to noise impact higher than the recommended limit. PMID:9483870

  9. Potential of neuro-fuzzy methodology to estimate noise level of wind turbines

    Nikolić, Vlastimir; Petković, Dalibor; Por, Lip Yee; Shamshirband, Shahaboddin; Zamani, Mazdak; Ćojbašić, Žarko; Motamedi, Shervin

    2016-01-01

    Wind turbines noise effect became large problem because of increasing of wind farms numbers since renewable energy becomes the most influential energy sources. However, wind turbine noise generation and propagation is not understandable in all aspects. Mechanical noise of wind turbines can be ignored since aerodynamic noise of wind turbine blades is the main source of the noise generation. Numerical simulations of the noise effects of the wind turbine can be very challenging task. Therefore in this article soft computing method is used to evaluate noise level of wind turbines. The main goal of the study is to estimate wind turbine noise in regard of wind speed at different heights and for different sound frequency. Adaptive neuro-fuzzy inference system (ANFIS) is used to estimate the wind turbine noise levels.

  10. Noise and Hearing Loss Prevention

    ... Follow us on Twitter Noise Manufacturing Construction SafeInSound Noise and Hearing Loss on the NIOSH Science Blog ... Topics Publications and Products Programs Contact NIOSH NIOSH NOISE AND HEARING LOSS PREVENTION Recommend on Facebook Tweet ...

  11. Photon shot noise

    Beenakker, C. W. J.; Patra, M.

    1999-01-01

    A recent theory is reviewed for the shot noise of coherent radiation propagating through a random medium. The Fano factor P/I (the ratio of the noise power and the mean transmitted current) is related to the scattering matrix of the medium. This is the optical analogue of Buttiker's formula for electronic shot noise. Scattering by itself has no effect on the Fano factor, which remains equal to 1 (as for a Poisson process). Absorption and amplification both increase the Fano factor above the P...

  12. NOISE POLLUTION IN MUMBAI

    Khamkar S. P.

    2016-01-01

    According to the World Health Organization (WHO), noise is a second only to air pollution in the impact it has on health. Mumbai is the nosiest city in the world. Traffic is a continuous source of noise. 21 Century has three grave problems, namely growth of population, conicperversity and pollution. If we have to survive, pollution is the most dangerous problems like a cancer in which death is sure but slow. Maharashtra pollution Control Board (MPCB) has given zone wise noise level limits. No...

  13. Controlled Noise Seismology

    Hanafy, Sherif M.

    2015-08-19

    We use controlled noise seismology (CNS) to generate surface waves, where we continuously record seismic data while generating artificial noise along the profile line. To generate the CNS data we drove a vehicle around the geophone line and continuously recorded the generated noise. The recorded data set is then correlated over different time windows and the correlograms are stacked together to generate the surface waves. The virtual shot gathers reveal surface waves with moveout velocities that closely approximate those from active source shot gathers.

  14. Noise: sound reactive fashion

    Paiva, André; Catarino, André P.; Cabral, Isabel; Carvalho, Helder

    2015-01-01

    Sound and noise have an important influence in our daily lives. They can positively or negatively change our quality of life. Given the idea that it is harder to ignore what we see, rather than what we hear, the team developed a garment that senses environmental noise and shows it through lighting, to make people aware of the noise around them. The garment chosen was a jacket, with a deliberately provocative design. It is the authors’ intention to study the integration of lighting in garments...

  15. Noise blind test

    H. Cadet

    2006-01-01

    In the aim of characterizing site condition for seismic risk, the microtremor or ambient noise studies have been developed. The main objective of this blind test is to check of the reliability of results, to observe the user subjectivity (array choice, parameters that are user depend) in the noise recordings analyze. Noise records were analysed on single-station with H/V method and with several sensors for array method to determine the dispersion characteristics of the surface-wave part of th...

  16. Hypermedicalization in White Noise.

    Benson, Josef

    2015-09-01

    The Nazis hijacked Germany's medical establishment and appropriated medical language to hegemonize their ideology. In White Noise, shifting medical information stifles the public into docility. In Nazi Germany the primacy of language and medical authority magnified the importance of academic doctors. The muddling of identities caused complex insecurities and the need for psychological doubles. In White Noise, Professor Gladney is driven by professional insecurities to enact a double in Murray. Through the manipulation of language and medical overreach the U.S., exemplified in the novel White Noise, has become a hypermedicalized society where the spirit of the Hippocratic Oath has eroded. PMID:24458659

  17. Criteria for environmental noise assessment

    Hadzi-Nikolova, Marija; Mirakovski, Dejan; Doneva, Nikolinka

    2015-01-01

    The noise assessment generally refers to the assessment of noise impact from a specific source, such as noise originating from certain industrial plants, road traffic, and this is not always an easy task. Practically in every surrounding, a number of different sources contribute to the ambiental noise at a certain point. Standardization of noise level includes recommendations for noise level prescribed by legislation, which are enabling stay in the environment without danger to human heal...

  18. Handbook Of Noise And Vibration

    This book is about noise and vibration. The first chapter has explanations of noise such as basic of sound, influence of noise, assessment of noise, measurement of prevention of noise and technology, case of noise measurement and soundproof. The second chapter describes vibration with outline, theory of vibration, interpretation of vibration, measurement for reduction of vibration, case of design of protection against vibration. It deals with related regulation and method of measurement.

  19. Radiation-force-based estimation of acoustic attenuation using harmonic motion imaging (HMI) in phantoms and in vitro livers before and after HIFU ablation

    Chen, Jiangang; Hou, Gary Y.; Marquet, Fabrice; Han, Yang; Camarena, Francisco; Konofagou, Elisa

    2015-10-01

    Acoustic attenuation represents the energy loss of the propagating wave through biological tissues and plays a significant role in both therapeutic and diagnostic ultrasound applications. Estimation of acoustic attenuation remains challenging but critical for tissue characterization. In this study, an attenuation estimation approach was developed using the radiation-force-based method of harmonic motion imaging (HMI). 2D tissue displacement maps were acquired by moving the transducer in a raster-scan format. A linear regression model was applied on the logarithm of the HMI displacements at different depths in order to estimate the acoustic attenuation. Commercially available phantoms with known attenuations (n=5 ) and in vitro canine livers (n=3 ) were tested, as well as HIFU lesions in in vitro canine livers (n=5 ). Results demonstrated that attenuations obtained from the phantoms showed a good correlation ({{R}2}=0.976 ) with the independently obtained values reported by the manufacturer with an estimation error (compared to the values independently measured) varying within the range of 15-35%. The estimated attenuation in the in vitro canine livers was equal to 0.32   ±   0.03 dB cm-1 MHz-1, which is in good agreement with the existing literature. The attenuation in HIFU lesions was found to be higher (0.58   ±   0.06 dB cm-1 MHz-1) than that in normal tissues, also in agreement with the results from previous publications. Future potential applications of the proposed method include estimation of attenuation in pathological tissues before and after thermal ablation.

  20. Radiation-force-based estimation of acoustic attenuation using harmonic motion imaging (HMI) in phantoms and in vitro livers before and after HIFU ablation.

    Chen, Jiangang; Hou, Gary Y; Marquet, Fabrice; Han, Yang; Camarena, Francisco; Konofagou, Elisa

    2015-10-01

    Acoustic attenuation represents the energy loss of the propagating wave through biological tissues and plays a significant role in both therapeutic and diagnostic ultrasound applications. Estimation of acoustic attenuation remains challenging but critical for tissue characterization. In this study, an attenuation estimation approach was developed using the radiation-force-based method of harmonic motion imaging (HMI). 2D tissue displacement maps were acquired by moving the transducer in a raster-scan format. A linear regression model was applied on the logarithm of the HMI displacements at different depths in order to estimate the acoustic attenuation. Commercially available phantoms with known attenuations (n = 5) and in vitro canine livers (n = 3) were tested, as well as HIFU lesions in in vitro canine livers (n = 5). Results demonstrated that attenuations obtained from the phantoms showed a good correlation (R² = 0.976) with the independently obtained values reported by the manufacturer with an estimation error (compared to the values independently measured) varying within the range of 15-35%. The estimated attenuation in the in vitro canine livers was equal to 0.32   ±   0.03 dB cm(-1) MHz(-1), which is in good agreement with the existing literature. The attenuation in HIFU lesions was found to be higher (0.58   ±   0.06 dB cm(-1) MHz(-1)) than that in normal tissues, also in agreement with the results from previous publications. Future potential applications of the proposed method include estimation of attenuation in pathological tissues before and after thermal ablation. PMID:26371501