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Sample records for adaboost-based multiple svm-rfe

  1. Improving enzyme regulatory protein classification by means of SVM-RFE feature selection.

    Fernandez-Lozano, Carlos; Fernández-Blanco, Enrique; Dave, Kirtan; Pedreira, Nieves; Gestal, Marcos; Dorado, Julián; Munteanu, Cristian R

    2014-05-01

    Enzyme regulation proteins are very important due to their involvement in many biological processes that sustain life. The complexity of these proteins, the impossibility of identifying direct quantification molecular properties associated with the regulation of enzymatic activities, and their structural diversity creates the necessity for new theoretical methods that can predict the enzyme regulatory function of new proteins. The current work presents the first classification model that predicts protein enzyme regulators using the Markov mean properties. These protein descriptors encode the topological information of the amino acid into contact networks based on amino acid distances and physicochemical properties. MInD-Prot software calculated these molecular descriptors for 2415 protein chains (350 enzyme regulators) using five atom physicochemical properties (Mulliken electronegativity, Kang-Jhon polarizability, vdW area, atom contribution to P) and the protein 3D regions. The best classification models to predict enzyme regulators have been obtained with machine learning algorithms from Weka using 18 features. K* has been demonstrated to be the most accurate algorithm for this protein function classification. Wrapper Subset Evaluator and SVM-RFE approaches were used to perform a feature subset selection with the best results obtained from SVM-RFE. Classification performance employing all the available features can be reached using only the 8 most relevant features selected by SVM-RFE. Thus, the current work has demonstrated the possibility of predicting new molecular targets involved in enzyme regulation using fast theoretical algorithms. PMID:24556806

  2. 基于Relief和SVM-RFE的组合式SNP特征选择%Combined SNP feature selection based on relief and SVM-RFE

    吴红霞; 吴悦; 刘宗田; 雷州

    2012-01-01

    The genome-wide association study (CWAS)on SNPs faces two big issues; high dimensional SNP data with small sample characteristics and complex mechanisms of genetic diseases. Tin's paper proposed a combined SNP feature selection method through bring feature selection methods into GWAS. The method included two stages: filter stage, it used Relief algorithm to eliminate irrelevant SNP features, wrapper stage, it used support vector machine based recursive feature reduction (SVM-RFE) algorithm to select the key SNPs set. Experiments show that the proposed method has an obviously better performance than SVM RFE algorithm, and also gains higher classification accuracy than Relief-SVM algorithm, which provides an effective way for SNP genome-wide association analysis.%针对SNP的全基因组关联分析面临SNP数据的高维小样本特性和遗传疾病病理的复杂性两大难点,将特征选择引入SNP全基因组关联分析中,提出基于Relief和SVM-RFE的组合式SNP特征选择方法.该方法包括两个阶段:Filter阶段,使用Relief算法剔除无关SNPs;Wrapper阶段,使用基于支持向量机的特征递归消减方法( SVM-RFE)筛选出与遗传疾病相关的关键SNPs.实验表明,该方法具有明显优于单独使用SVM-RFE算法的性能,优于单独使用Relief-SVM算法的分类准确率,为SNP全基因组关联分析提供了一种有效途径.

  3. Robust Ground Target Detection by SAR and IR Sensor Fusion Using Adaboost-Based Feature Selection.

    Kim, Sungho; Song, Woo-Jin; Kim, So-Hyun

    2016-01-01

    Long-range ground targets are difficult to detect in a noisy cluttered environment using either synthetic aperture radar (SAR) images or infrared (IR) images. SAR-based detectors can provide a high detection rate with a high false alarm rate to background scatter noise. IR-based approaches can detect hot targets but are affected strongly by the weather conditions. This paper proposes a novel target detection method by decision-level SAR and IR fusion using an Adaboost-based machine learning scheme to achieve a high detection rate and low false alarm rate. The proposed method consists of individual detection, registration, and fusion architecture. This paper presents a single framework of a SAR and IR target detection method using modified Boolean map visual theory (modBMVT) and feature-selection based fusion. Previous methods applied different algorithms to detect SAR and IR targets because of the different physical image characteristics. One method that is optimized for IR target detection produces unsuccessful results in SAR target detection. This study examined the image characteristics and proposed a unified SAR and IR target detection method by inserting a median local average filter (MLAF, pre-filter) and an asymmetric morphological closing filter (AMCF, post-filter) into the BMVT. The original BMVT was optimized to detect small infrared targets. The proposed modBMVT can remove the thermal and scatter noise by the MLAF and detect extended targets by attaching the AMCF after the BMVT. Heterogeneous SAR and IR images were registered automatically using the proposed RANdom SAmple Region Consensus (RANSARC)-based homography optimization after a brute-force correspondence search using the detected target centers and regions. The final targets were detected by feature-selection based sensor fusion using Adaboost. The proposed method showed good SAR and IR target detection performance through feature selection-based decision fusion on a synthetic database generated

  4. Robust Ground Target Detection by SAR and IR Sensor Fusion Using Adaboost-Based Feature Selection

    Sungho Kim

    2016-07-01

    Full Text Available Long-range ground targets are difficult to detect in a noisy cluttered environment using either synthetic aperture radar (SAR images or infrared (IR images. SAR-based detectors can provide a high detection rate with a high false alarm rate to background scatter noise. IR-based approaches can detect hot targets but are affected strongly by the weather conditions. This paper proposes a novel target detection method by decision-level SAR and IR fusion using an Adaboost-based machine learning scheme to achieve a high detection rate and low false alarm rate. The proposed method consists of individual detection, registration, and fusion architecture. This paper presents a single framework of a SAR and IR target detection method using modified Boolean map visual theory (modBMVT and feature-selection based fusion. Previous methods applied different algorithms to detect SAR and IR targets because of the different physical image characteristics. One method that is optimized for IR target detection produces unsuccessful results in SAR target detection. This study examined the image characteristics and proposed a unified SAR and IR target detection method by inserting a median local average filter (MLAF, pre-filter and an asymmetric morphological closing filter (AMCF, post-filter into the BMVT. The original BMVT was optimized to detect small infrared targets. The proposed modBMVT can remove the thermal and scatter noise by the MLAF and detect extended targets by attaching the AMCF after the BMVT. Heterogeneous SAR and IR images were registered automatically using the proposed RANdom SAmple Region Consensus (RANSARC-based homography optimization after a brute-force correspondence search using the detected target centers and regions. The final targets were detected by feature-selection based sensor fusion using Adaboost. The proposed method showed good SAR and IR target detection performance through feature selection-based decision fusion on a synthetic

  5. EEG study on affective valence elicited by novel and familiar pictures using ERD/ERS and SVM-RFE.

    Hidalgo-Muñoz, A R; López, M M; Galvao-Carmona, A; Pereira, A T; Santos, I M; Vázquez-Marrufo, M; Tomé, A M

    2014-02-01

    EEG signals have been widely explored in emotional processing analyses, both in time and frequency domains. However, in such studies, habituation phenomenon is barely considered in the discrimination of different emotional responses. In this work, spectral features of the event-related potentials (ERPs) are studied by means of event-related desynchronization/synchronization computation. In order to determine the most relevant ERP features for distinguishing how positive and negative affective valences are processed within the brain, support vector machine-recursive feature elimination is employed. The proposed approach was applied for investigating in which way the familiarity of stimuli affects the affective valence processing as well as which frequency bands and scalp regions are more involved in this process. In a group composed of young adult women, results prove that parietooccipital region and theta band are especially involved in the processing of novelty in emotional stimuli. Furthermore, the proposed method has shown to perform successfully using a moderated number of trials. PMID:24257836

  6. Research on Feature Selection Method Based on Improved SVM- RFE%基于改进SVM-RFE的特征选择方法研究

    王俭臣; 单甘霖; 张岐龙; 段修生

    2011-01-01

    SVM-RFE特征选择算法是一种有效的特征选择方法,具有较高的应用价值.针对传统SVM-RFE特征选择算法中SVM参数(γ和C)难以确定的问题,本文采用粒子群算法搜索SVM的参数.然后将特征向量映射到SVM参数γ确定的核空间中并进行特征选择,有效地将特征选择与SVM分类器设计关联起来.仿真结果表明,特征选择后的数据集仍能保证SVM分类器具有较高的分类正确率.

  7. Privacy Preserving RFE-SVM for Distributed Gene Selection

    Fode Camara

    2012-01-01

    Full Text Available The support vector machine recursive feature elimination (SVM-RFE is one of the most effective feature selection methods which has been successfully used in selecting informative genes for cancer classification. This paper extends this well-studied algorithm to the privacy preserving distributed data mining issue. For gene selection over multiple patient data from different sites, we propose a novel RFE-SVM method which aims to learn global informative gene subset to get the highest cancer classification accuracy, with limits on sharing of information. We experiment it using Leukemia bio-medical dataset. The experimental results show that it can provide good capability of privacy preserving and generates a set of attributes that is very similar to the set produced by its centralized counterpart.

  8. Multiple Perspectives / Multiple Readings

    Simon Biggs

    2005-01-01

    Full Text Available People experience things from their own physical point of view. What they see is usually a function of where they are and what physical attitude they adopt relative to the subject. With augmented vision (periscopes, mirrors, remote cameras, etc we are able to see things from places where we are not present. With time-shifting technologies, such as the video recorder, we can also see things from the past; a time and a place we may never have visited.In recent artistic work I have been exploring the implications of digital technology, interactivity and internet connectivity that allow people to not so much space/time-shift their visual experience of things but rather see what happens when everybody is simultaneously able to see what everybody else can see. This is extrapolated through the remote networking of sites that are actual installation spaces; where the physical movements of viewers in the space generate multiple perspectives, linked to other similar sites at remote locations or to other viewers entering the shared data-space through a web based version of the work.This text explores the processes involved in such a practice and reflects on related questions regarding the non-singularity of being and the sense of self as linked to time and place.

  9. Multiple Pregnancy

    ... Can multiple pregnancy affect my risk of postpartum depression? Having multiples might increase your risk of postpartum ... Membership For Journalists For Junior Fellows For Medical Students For Patients Contact Us Copyright Information Privacy Statement ...

  10. Multiple Myeloma

    Multiple myeloma is a cancer that begins in plasma cells, a type of white blood cell. These cells ... bones. No one knows the exact causes of multiple myeloma, but it is more common in older people ...

  11. Multiple Sclerosis

    Multiple sclerosis (MS) is a nervous system disease that affects your brain and spinal cord. It damages the ... attacks healthy cells in your body by mistake. Multiple sclerosis affects women more than men. It often begins ...

  12. Multiplicity Counting

    Geist, William H. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-12-01

    This set of slides begins by giving background and a review of neutron counting; three attributes of a verification item are discussed: 240Pueff mass; α, the ratio of (α,n) neutrons to spontaneous fission neutrons; and leakage multiplication. It then takes up neutron detector systems – theory & concepts (coincidence counting, moderation, die-away time); detector systems – some important details (deadtime, corrections); introduction to multiplicity counting; multiplicity electronics and example distributions; singles, doubles, and triples from measured multiplicity distributions; and the point model: multiplicity mathematics.

  13. MULTIPLE OBJECTS

    A. A. Bosov

    2015-04-01

    Full Text Available Purpose. The development of complicated techniques of production and management processes, information systems, computer science, applied objects of systems theory and others requires improvement of mathematical methods, new approaches for researches of application systems. And the variety and diversity of subject systems makes necessary the development of a model that generalizes the classical sets and their development – sets of sets. Multiple objects unlike sets are constructed by multiple structures and represented by the structure and content. The aim of the work is the analysis of multiple structures, generating multiple objects, the further development of operations on these objects in application systems. Methodology. To achieve the objectives of the researches, the structure of multiple objects represents as constructive trio, consisting of media, signatures and axiomatic. Multiple object is determined by the structure and content, as well as represented by hybrid superposition, composed of sets, multi-sets, ordered sets (lists and heterogeneous sets (sequences, corteges. Findings. In this paper we study the properties and characteristics of the components of hybrid multiple objects of complex systems, proposed assessments of their complexity, shown the rules of internal and external operations on objects of implementation. We introduce the relation of arbitrary order over multiple objects, we define the description of functions and display on objects of multiple structures. Originality.In this paper we consider the development of multiple structures, generating multiple objects.Practical value. The transition from the abstract to the subject of multiple structures requires the transformation of the system and multiple objects. Transformation involves three successive stages: specification (binding to the domain, interpretation (multiple sites and particularization (goals. The proposed describe systems approach based on hybrid sets

  14. Multiple sclerosis

    Multiple sclerosis is the most common chronic inflammatory disease of myelin with interspersed lesions in the white matter of the central nervous system. Magnetic resonance imaging (MRI) plays a key role in the diagnosis and monitoring of white matter diseases. This article focuses on key findings in multiple sclerosis as detected by MRI. (orig.)

  15. Optimized spatio-temporal descriptors for real-time fall detection: comparison of support vector machine and Adaboost-based classification

    Charfi, Imen; Miteran, Johel; Dubois, Julien; Atri, Mohamed; Tourki, Rached

    2013-10-01

    We propose a supervised approach to detect falls in a home environment using an optimized descriptor adapted to real-time tasks. We introduce a realistic dataset of 222 videos, a new metric allowing evaluation of fall detection performance in a video stream, and an automatically optimized set of spatio-temporal descriptors which fed a supervised classifier. We build the initial spatio-temporal descriptor named STHF using several combinations of transformations of geometrical features (height and width of human body bounding box, the user's trajectory with her/his orientation, projection histograms, and moments of orders 0, 1, and 2). We study the combinations of usual transformations of the features (Fourier transform, wavelet transform, first and second derivatives), and we show experimentally that it is possible to achieve high performance using support vector machine and Adaboost classifiers. Automatic feature selection allows to show that the best tradeoff between classification performance and processing time is obtained by combining the original low-level features with their first derivative. Hence, we evaluate the robustness of the fall detection regarding location changes. We propose a realistic and pragmatic protocol that enables performance to be improved by updating the training in the current location with normal activities records.

  16. Multiple myeloma.

    Collins, Conor D

    2012-02-01

    Advances in the imaging and treatment of multiple myeloma have occurred over the past decade. This article summarises the current status and highlights how an understanding of both is necessary for optimum management.

  17. Multiple myeloma

    Conventional radiography is the means generally used in the assessment of skeletal involvement in multiple myeloma. Many findings such as osteolytic lesions, fractures, and osteoporosis are characteristic of myeloma. However, it seems likely that the extent of bone destruction is sometimes underestimated by radiography. Bone scintigraphy is considered a sensitive technique for the detection of skeletal metastatic lesions, but contradictory results have been reported in multiple myeloma, and many reports indicate that bone scintigraphy is less effective than conventional radiography. This phenomenon could depend on the fact that myeloma is a bone-marrow disease; bone structure is only indirectly involved; furthermore, studies have demonstrated that myelomatous lesions induce, by osteclast activation, larger bone resorption than new bone formation. On this basis the authors proposed the evaluation of bone marrow scanning plus bone scanning in comparison to conventional diagnostic radiology for the detection of skeletal involvement in multiple myeloma

  18. Multiple Sclerosis.

    Plummer, Nancy; Michael, Nancy, Ed.

    This module on multiple sclerosis is intended for use in inservice or continuing education programs for persons who administer medications in long-term care facilities. Instructor information, including teaching suggestions, and a listing of recommended audiovisual materials and their sources appear first. The module goal and objectives are then…

  19. Multiple myeloma

    Multiple myeloma is a malignant plasma cell tumor that is thought to originate proliferation of a single clone of abnormal plasma cell resulting production of a whole monoclonal paraprotein. The authors experienced a case of multiple myeloma with severe mandibular osteolytic lesions in 46-year-old female. As a result of careful analysis of clinical, radiological, histopathological features, and laboratory findings, we diagnosed it as multiple myeloma, and the following results were obtained. 1. Main clinical symptoms were intermittent dull pain on the mandibular body area, abnormal sensation of lip and pain due to the fracture on the right clavicle. 2. Laboratory findings revealed M-spike, reversed serum albumin-globulin ratio, markedly elevated ESR and hypercalcemia. 3. Radiographically, multiple osteolytic punched-out radiolucencies were evident on the skull, zygoma, jaw bones, ribs, clavicle and upper extremities. Enlarged liver and increased uptakes on the lesional sites in RN scan were also observed. 4. Histopathologically, markedly hypercellular marrow with sheets of plasmoblasts and megakaryocytes were also observed.

  20. Multiple Sklerose

    Hoffmann, Sarah

    2010-01-01

    Background: Multiple Sclerosis (MS) is the most common disabling neurological disease affecting young adults and the number of chronically sick MS patients to be found in the world of employment is on the increase. Research activities in the field of MS are numerous and wide-ranging. However, precise bibliometric analyses of research on the subject of MS do not exist so far. Methods: The present dissertation employs classical bibliometric tools with novel scientometric and visualizing tec...

  1. Multiple myeloma

    This chapter overviews the outcome of the previous studies on multiple myeloma and its related diseases. The incidence of multiple myeloma has become frequent 20 years after A-bombing. As of 1976, it is found to be increased, depending upon bone marrow doses of 50 rad or more (based on T65DR). This is noticeable in A-bomb survivors aged 20-59 years at the time of exposure. The number of autopsy cases has been increased since 1975, and has been significantly high since 1981. Mass screening for A-bomb survivors has revealed the existence of M proteinemia characterized by findings similar to those of multiple myeloma and benign monoclonal gammopathy. There is no significant difference in the incidence of subtype of M proteinemia by distance from the hypocenter. These findings suggest that M proteinemia may be one of the delayed effects of A-bomb radiation. Otherwise, an increased incidence of M proteinemia may be attributable to the cancer-prone age in A-bomb survivors aged 30 years or less at the time of exposure. (N.K.)

  2. Multiple sclerosis

    Eleven patients with a definite diagnosis of multiple sclerosis were examined in terms of correlations between the clinical features and the results of cranial computed tomography (CT), and magnetic resonance imaging (MRI). Results: In 5 of the 11 patients, both CT and MRI demonstrated lesions consistent with a finding of multiple sclerosis. In 3 patients, only MRI demonstrated lesions. In the remaining 3 patients, neither CT nor MRI revealed any lesion in the brain. All 5 patients who showed abnormal findings on both CT and MRI had clinical signs either of cerebral or brainstem - cerebellar lesions. On the other hand, two of the 3 patients with normal CT and MRI findings had optic-nerve and spinal-cord signs. Therefore, our results suggested relatively good correlations between the clinical features, CT, and MRI. MRI revealed cerebral lesions in two of the four patients with clinical signs of only optic-nerve and spinal-cord lesions. MRI demonstrated sclerotic lesions in 3 of the 6 patients whose plaques were not detected by CT. In conclusion, MRI proved to be more helpful in the demonstration of lesions attributable to chronic multiple sclerosis. (author)

  3. Intelligences multiples

    Partoune, Christine

    2010-01-01

    La conception d’un accompagnement méthodologique dans le but de favoriser un changement de pratiques implique une référence à des modèles de l’apprentissage que l’on espère cohérents avec les finalités poursuivies. Le but de cette fiche est de présenter la théorie des intelligences multiples proposée par Howard Gardner, qui nous invite au respect et à la prise en compte des différences entre les individus dans les pratiques en matière de gouvernance.

  4. Multiple sclerosis

    Stenager, Egon; Stenager, E N; Knudsen, Lone;

    1994-01-01

    , need for structural changes in home and need for pension became greater with increasing physical handicap. No significant differences between gender were found. It is concluded that patients and relatives are under increased social strain, when multiple sclerosis progresses to a moderate handicap....... Ninety-five percent lived in own house or flat and 70 percent received disablement pension. More than half of the patients (56.4 percent) were dependent on help from close relatives, most frequently spouse. The need for help, the risk of divorce, loss of contact with relatives, difficulty in going out...

  5. Multiple Myeloma Overview

    ... Web version Multiple Myeloma Overview What is multiple myeloma? Multiple myeloma (say: my-a-low-ma) is a ... Do I need to be screened for multiple myeloma? Source Multiple Myeloma: Recognition and Management by ED George, R ...

  6. [Multiple myeloma].

    Kortüm, K M; Engelhardt, M; Rasche, L; Knop, S; Einsele, H

    2013-08-01

    Multiple myeloma (MM) is a cancer originating from terminally differentiated B lymphocytes, the plasma cells and is classified as a B cell non-Hodgkin lymphoma. As clonal plasma cells secrete immunoglobulin molecules (lacking antigenic specificity), an "M component" can incidentally be detected. Besides intact immunoglobulin molecules, free light chains can be produced. Although there is no specific treatment for monoclonal gammopathy of undetermined significance (MGUS), which is the defined as the presence of clonal bone marrow plasma cells and low levels (serum and/or urine) of the M component, it should be followed up in affected individuals. The symptoms of MM are numerous and often nonspecific. Diagnosis includes the quantification of monoclonal proteins in serum and urine, blood count, electrolytes and renal function, imaging of the skeleton and bone marrow puncture. The cornerstone of therapy includes melphalan- or cyclophosphamide-based regimens incorporating one of the "novel drugs" (i.e. bortezomib, thalidomide, or lenalidomide). PMID:23860514

  7. Multiple System Atrophy

    ... Enhancing Diversity Find People About NINDS NINDS Multiple System Atrophy Information Page Condensed from Multiple System Atrophy ... Trials Organizations Publicaciones en Español What is Multiple System Atrophy? Multiple system atrophy (MSA) is a progressive ...

  8. Multiple Myeloma Symptoms

    ... Center Finder Home » About Multiple Myeloma » Symptoms Multiple Myeloma Symptoms Multiple myeloma symptoms may vary by patient, with the ... to be managed or prevented. The most common multiple myeloma symptoms may include: Bone pain or bone fractures ...

  9. Multiple Myeloma Research Foundation

    ... modal.css('left',left+'px'); } Welcome to the Multiple Myeloma Research Foundation The Multiple Myeloma Research Foundation (MMRF) ... Stay informed with our newsletter. If you have multiple myeloma, you have options. At the MMRF, we’re ...

  10. On Multiplicative Fractional Calculus

    Abdeljawad, Thabet

    2015-01-01

    We set the main concepts for multiplicative fractional calculus. We define Caputo, Riemann and Letnikov multiplicative fractional derivatives and multiplicative fractional integrals and study some of their properties. Finally, the multiplicative analogue of the local conformable fractional derivative and integral is studied.

  11. Multiple-Ring Digital Communication Network

    Kirkham, Harold

    1992-01-01

    Optical-fiber digital communication network to support data-acquisition and control functions of electric-power-distribution networks. Optical-fiber links of communication network follow power-distribution routes. Since fiber crosses open power switches, communication network includes multiple interconnected loops with occasional spurs. At each intersection node is needed. Nodes of communication network include power-distribution substations and power-controlling units. In addition to serving data acquisition and control functions, each node acts as repeater, passing on messages to next node(s). Multiple-ring communication network operates on new AbNET protocol and features fiber-optic communication.

  12. Multiple mirror plasma confinement

    Multiple mirror plasma confinement concept is considered. A theory of plasma diffusion through a corrugated magnetic field is developed. It is shown, that multiple mirror devices hold considerable promise for confining fusion plasmas. 75 refs.; 8 figs.; 4 tabs

  13. Challenges of Parenting Multiples

    ... the American Society for Reproductive Medicine Challenges of Parenting Multiples There are many psychological, social, and economic ... the unique challenges and rewards that come from parenting multiples. For more information on the medical aspects ...

  14. Generalized internal multiple imaging

    Zuberi, Mohammad Akbar Hosain

    2014-12-04

    Various examples are provided for generalized internal multiple imaging (GIMI). In one example, among others, a method includes generating a higher order internal multiple image using a background Green\\'s function and rendering the higher order internal multiple image for presentation. In another example, a system includes a computing device and a generalized internal multiple imaging (GIMI) application executable in the computing device. The GIMI application includes logic that generates a higher order internal multiple image using a background Green\\'s function and logic that renders the higher order internal multiple image for display on a display device. In another example, a non-transitory computer readable medium has a program executable by processing circuitry that generates a higher order internal multiple image using a background Green\\'s function and renders the higher order internal multiple image for display on a display device.

  15. Multiple Mucosal Neuroma Syndrome

    Thami Gurvinder P

    1997-01-01

    Full Text Available A case of multiple mucosal neuroma syndrome recently classified as Multiple Endocrinal Neoplasia (MEN, type 2b, is reported for its rarity and importance of diagnosis at an early age.

  16. Caring for Multiples

    ... labor & premature birth The newborn intensive care unit (NICU) Birth defects & other health conditions Loss & grief Tools & ... Home > Complications & Loss > The newborn intensive care unit (NICU) > Caring for multiples Caring for multiples E-mail ...

  17. Depression and Multiple Sclerosis

    Depression - National Multiple Sclerosis Society Skip to navigation Skip to content Menu Navigation National Multiple Sclerosis Society ... Twitter Email Home Symptoms & Diagnosis MS Symptoms Depression Depression Share Smaller Text Larger Text Print In this ...

  18. ALICE Forward Multiplicity Detector

    Christensen, C

    2013-01-01

    The Forward Multiplicity Detector (FMD) extends the coverage for multiplicity of charge particles into the forward regions - giving ALICE the widest coverage of the 4 LHC experiments for these measurements.

  19. Multiple sclerosis - discharge

    Your doctor has told you that you have multiple sclerosis. This disease affects the brain and spinal cord ( ... your doctor may prescribe medicine. Some people with multiple sclerosis need to use a urinary catheter . This is ...

  20. Fatigue and Multiple Sclerosis

    Fatigue - National Multiple Sclerosis Society Skip to navigation Skip to content Menu Navigation National Multiple Sclerosis Society ... Twitter Email Home Symptoms & Diagnosis MS Symptoms Fatigue Fatigue Share Smaller Text Larger Text Print In this ...

  1. Multiple Indicators, Multiple Causes Measurement Error Models

    Tekwe, Carmen D.; Carter, Randy L.; Cullings, Harry M.; Carroll, Raymond J.

    2014-01-01

    Multiple Indicators, Multiple Causes Models (MIMIC) are often employed by researchers studying the effects of an unobservable latent variable on a set of outcomes, when causes of the latent variable are observed. There are times however when the causes of the latent variable are not observed because measurements of the causal variable are contaminated by measurement error. The objectives of this paper are: (1) to develop a novel model by extending the classical linear MIMIC model to allow bot...

  2. Multiple emulsions: an overview.

    Khan, Azhar Yaqoob; Talegaonkar, Sushama; Iqbal, Zeenat; Ahmed, Farhan Jalees; Khar, Roop Krishan

    2006-10-01

    Multiple emulsions are complex polydispersed systems where both oil in water and water in oil emulsion exists simultaneously which are stabilized by lipophillic and hydrophilic surfactants respectively. The ratio of these surfactants is important in achieving stable multiple emulsions. Among water-in-oil-in-water (w/o/w) and oil-in-water-in-oil (o/w/o) type multiple emulsions, the former has wider areas of application and hence are studied in great detail. Formulation, preparation techniques and in vitro characterization methods for multiple emulsions are reviewed. Various factors affecting the stability of multiple emulsions and the stabilization approaches with specific reference to w/o/w type multiple emulsions are discussed in detail. Favorable drug release mechanisms and/or rate along with in vivo fate of multiple emulsions make them a versatile carrier. It finds wide range of applications in controlled or sustained drug delivery, targeted delivery, taste masking, bioavailability enhancement, enzyme immobilization, etc. Multiple emulsions have also been employed as intermediate step in the microencapsulation process and are the systems of increasing interest for the oral delivery of hydrophilic drugs, which are unstable in gastrointestinal tract like proteins and peptides. With the advancement in techniques for preparation, stabilization and rheological characterization of multiple emulsions, it will be able to provide a novel carrier system for drugs, cosmetics and pharmaceutical agents. In this review, emphasis is laid down on formulation, stabilization techniques and potential applications of multiple emulsion system. PMID:17076645

  3. Inference for Multiplicative Models

    Wexler, Ydo; Meek, Christopher

    2012-01-01

    The paper introduces a generalization for known probabilistic models such as log-linear and graphical models, called here multiplicative models. These models, that express probabilities via product of parameters are shown to capture multiple forms of contextual independence between variables, including decision graphs and noisy-OR functions. An inference algorithm for multiplicative models is provided and its correctness is proved. The complexity analysis of the inference algorithm uses a mor...

  4. Complex Multiplicative Calculus

    Bashirov, Agamirza; Riza, Mustafa

    2011-01-01

    In the present paper we extend the concepts of multiplicative de- rivative and integral to complex-valued functions of complex variable. Some drawbacks, arising with these concepts in the real case, are explained satis- factorily. Properties of complex multiplicative derivatives and integrals are studied. In particular, the fundamental theorem of complex multiplicative calculus, relating these concepts, is proved. It is shown that complex multi- plicative calculus is not just another realizat...

  5. Multiple Myeloma and Diabetes

    Azar, Sami T.; Mira S. Zantout; Zeinab A. Issa

    2011-01-01

    Multiple myeloma is a malignant plasma cell disorder that accounts for approximately 10% of all hematologic cancers. It is characterized by accumulation of clonal plasma cells, predominantly in the bone marrow. The prevalence of type 2 diabetes is increasing; therefore, it is expected that there will be an increase in the diagnosis of multiple myeloma with concomitant diabetes mellitus. The treatment of multiple myeloma and diabetes mellitus is multifaceted. The coexistence of the two conditi...

  6. A Multi-orientation Gabor Filter and Adaboost Based Iris Recognition Method%基于多方向Gabor滤波器和Adaboost的虹膜识别方法

    张祥德; 黎明奇; 王琪; 孙艳蕊

    2012-01-01

    A new method for iris feature extraction and recognition was proposed based on the global and local texture information of iris. The normalized iris was divided first. Then the multi- orientation Gabor filters were used to encode the whole iris and sub-block iris, and the feature vector was constructed. Furthermore, the Adaboost algorithm was adopted to choose some features whose recognition performances are good. The results of the experiments carried out on CASIA-IrisV3-Lamp database indicate that the accuracy of recognition reaches up to 99.85%. Moreover, the algorithm has good recognition performance on the NICE:

  7. The Accuracy of Multiples

    Stauropoulos Antonios

    2011-01-01

    Full Text Available Problem statement: Equity valuation with the use of multiples is widely used by academics and practitioners concerning its functionality. This study aims to explore the sensitivity of three multiples in terms of accuracy. Approach: Price-to-Sales (P/S multiple, the price-to-book value of equity (P/B multiple and the Price-to-Earnings (P/E multiple are three multiples under consideration, using both current and one-year-ahead earnings forecasts. Results: Evidence of empirical results show that, the multiples P/mdfy1 and P/mnfy1 are effective in terms of accuracy, with their means being negatively biased and their medians being positively biased. Finally, current earnings are identified as more appropriate value driver for the calculation of the P/E ratio by terms of accuracy. The results can be considered as reliable owing to the large sample and the procedure followed for its selection. Conclusion: This study offers a better understanding of the valuation approach through the use of multiples, in order analysts assumption to be more carefully and properly chosen and their results to be more accurately produced.

  8. ALICE Photon Multiplicity Detector

    Nayak, T

    2013-01-01

    Photon Multiplicity Detector (PMD) measures the multiplicity and spatial distribution of photons in the forward region of ALICE on a event-by-event basis. PMD is a pre-shower detector having fine granularity and full azimuthal coverage in the pseudo-rapidity region 2.3 < η < 3.9.

  9. Hadron Multiplicities at HERMES

    Hillenbrand, A.; Hartig, M.

    2005-01-01

    Hadron multiplicities of $\\pim$, $\\pip$, $\\km$ and $\\kp$ have been measured in the deep-inelastic scattering of 27.5 GeV positrons off a hydrogen target. The data used in this analysis have been collected during the 2000 HERA running period. The multiplicities were obtained for 0.15$< z

  10. Multiple Stages 2

    Andreasen, John

    Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations......Multiple stages 2: theatrical futures, set design, community plays, cultural capitals, democracy & drama, WWII dramas, performance on adoption, promenade about emigration, qualities in political theatre, performance analysis, dramaturgical education, Toulmin Variations...

  11. Suicide and multiple sclerosis

    Stenager, E N; Stenager, Egon; Koch-Henriksen, Nils;

    1992-01-01

    In a nationwide investigation the risk of death by suicide for patients with multiple sclerosis (MS) was assessed using records kept at the Danish Multiple Sclerosis Registry (DMSR) and the Danish National Register of Cause of Death. The investigation covers all MS patients registered with DSMR...

  12. Orchestrating Multiple Intelligences

    Moran, Seana; Kornhaber, Mindy; Gardner, Howard

    2006-01-01

    Education policymakers often go astray when they attempt to integrate multiple intelligences theory into schools, according to the originator of the theory, Howard Gardner, and his colleagues. The greatest potential of a multiple intelligences approach to education grows from the concept of a profile of intelligences. Each learner's intelligence…

  13. Applying Multiple Intelligences

    Christodoulou, Joanna A.

    2009-01-01

    The ideas of multiple intelligences introduced by Howard Gardner of Harvard University more than 25 years ago have taken form in many ways, both in schools and in other sometimes-surprising settings. The silver anniversary of Gardner's learning theory provides an opportunity to reflect on the ways multiple intelligences theory has taken form and…

  14. Constraining Multiple Grammars

    Hopp, Holger

    2014-01-01

    This article offers the author's commentary on the Multiple Grammars (MG) language acquisition theory proposed by Luiz Amaral and Tom Roeper in the present issue. Multiple Grammars advances the claim that optionality is a constitutive characteristic of any one grammar, with interlanguage grammars being perhaps the clearest examples of a…

  15. Safe Dynamic Multiple Inheritance

    Ernst, Erik

    2002-01-01

    Multiple inheritance and similar mechanisms are usually only supported at compile time in statically typed languages. Nevertheless, dynamic multiple inheritance would be very useful in the development of complex systems, because it allows the creation of many related classes without an explosion in...... the size and level of redundancy in the source code. In fact, dynamic multiple inheritance is already available. The language gbeta is statically typed and has supported run-time combination of classes and methods since 1997, by means of the combination operator '&'. However, with certain combinations...

  16. Bayesian multiple target tracking

    Streit, Roy L

    2013-01-01

    This second edition has undergone substantial revision from the 1999 first edition, recognizing that a lot has changed in the multiple target tracking field. One of the most dramatic changes is in the widespread use of particle filters to implement nonlinear, non-Gaussian Bayesian trackers. This book views multiple target tracking as a Bayesian inference problem. Within this framework it develops the theory of single target tracking, multiple target tracking, and likelihood ratio detection and tracking. In addition to providing a detailed description of a basic particle filter that implements

  17. Multiple scattering tomography.

    Modregger, Peter; Kagias, Matias; Peter, Silvia; Abis, Matteo; Guzenko, Vitaliy A; David, Christian; Stampanoni, Marco

    2014-07-11

    Multiple scattering represents a challenge for numerous modern tomographic imaging techniques. In this Letter, we derive an appropriate line integral that allows for the tomographic reconstruction of angular resolved scattering distributions, even in the presence of multiple scattering. The line integral is applicable to a wide range of imaging techniques utilizing various kinds of probes. Here, we use x-ray grating interferometry to experimentally validate the framework and to demonstrate additional structural sensitivity, which exemplifies the impact of multiple scattering tomography. PMID:25062159

  18. Multiple Myeloma: Patient Handbook

    ... contact us TEXT SIZE IMF Multiple Myeloma Patient Handbook 2016 One of the most daunting aspects of ... with each of these steps. The IMF’s Patient Handbook is meant to furnish you with the tools ...

  19. Connecting the Production Multiple

    Lichen, Alex Yu; Mouritsen, Jan

    was implementing sales and operations planning (S&OP) process to foster integration on its demand chain. Although actors wanted to see what it is to produce, that is to say, the object Production, as a singular object that could be diffused across time and space, Production became more multiple because the S......&OP process itself is a fluid object, but there is still possibility to organise the messy Production. There are connections between the Production multiple and the managerial technology fluid. The fluid enacted the multiplicity of Production thus making it more difficult to be organised because there were...... in this sense attracts different absent local practices, which in turn make accounting fluid to account for the Production multiple. The accounting fluid brings together accounting inscriptions and particularity of locals. In the language of circulating references, reduction and amplification no longer go...

  20. Rehabilitation and multiple sclerosis

    Dalgas, Ulrik

    2011-01-01

    In a chronic and disabling disease like multiple sclerosis, rehabilitation becomes of major importance in the preservation of physical, psychological and social functioning. Approximately 80% of patients have multiple sclerosis for more than 35 years and most will develop disability at some point...... of their lives, emphasising the importance of rehabilitation in order to maintain quality of life. An important aspect of multiple sclerosis rehabilitation is the preservation of physical functioning. Hot topics in the rehabilitation of physical function include (1) exercise therapy, (2) robot-assisted training...... and (3) pharmacological interventions. Exercise therapy has for many years been a controversial issue in multiple sclerosis rehabilitation and the advice generally given to patients was not to participate in physical exercise, since it was thought to lead to a worsening of symptoms or fatigue. However...

  1. Multiple sclerosis research

    This volume proceedings contains four contributions which are in INIS scope, dealing with MRI and SPECT in the diagnosis of multiple sclerosis and assessment of disease activity. (H.W.). refs.; figs.; tabs

  2. Pomalidomide for Multiple Myeloma

    A summary of results from a phase III trial that compared the combination of pomalidomide (Pomalyst®) and low-dose dexamethasone versus high-dose dexamethasone alone in patients with multiple myeloma that has progressed despite other treatments.

  3. Choice and multiple reinforcers

    Moore, Jay

    1982-01-01

    Pigeons chose between equivalent two-component mixed and multiple terminal-link schedules of reinforcement in the concurrent-chains procedure. The pigeons preferred the multiple schedule over the mixed when the components of the compound schedules were differentiated in terms of density of reinforcement, but the pigeons were indifferent when the components were differentiated in terms of number of reinforcers per cycle. Taken together, these results indicate that a local variable, the interva...

  4. Generalized internal multiple imaging

    Zuberi, M. A. H.

    2014-08-05

    Internal multiples deteriorate the image when the imaging procedure assumes only single scattering, especially if the velocity model does not have sharp contrasts to reproduce such scattering in the Green’s function through forward modeling. If properly imaged, internal multiples (internally scattered energy) can enhance the seismic image. Conventionally, to image internal multiples, accurate, sharp contrasts in the velocity model are required to construct a Green’s function with all the scattered energy. As an alternative, we have developed a generalized internal multiple imaging procedure that images any order internal scattering using the background Green’s function (from the surface to each image point), constructed from a smooth velocity model, usually used for conventional imaging. For the first-order internal multiples, the approach consisted of three steps, in which we first back propagated the recorded surface seismic data using the background Green’s function, then crosscorrelated the back-propagated data with the recorded data, and finally crosscorrelated the result with the original background Green’s function. This procedure images the contribution of the recorded first-order internal multiples, and it is almost free of the single-scattering recorded energy. The cost includes one additional crosscorrelation over the conventional single-scattering imaging application. We generalized this method to image internal multiples of any order separately. The resulting images can be added to the conventional single-scattering image, obtained, e.g., from Kirchhoff or reverse-time migration, to enhance the image. Application to synthetic data with reflectors illuminated by multiple scattering (double scattering) demonstrated the effectiveness of the approach.

  5. Angiogenesis and Multiple Myeloma

    Giuliani, Nicola; Storti, Paola; Bolzoni, Marina; Palma, Benedetta Dalla; Bonomini, Sabrina

    2011-01-01

    The bone marrow microenvironment in multiple myeloma is characterized by an increased microvessel density. The production of pro-angiogenic molecules is increased and the production of angiogenic inhibitors is suppressed, leading to an “angiogenic switch”. Here we present an overview of the role of angiogenesis in multiple myeloma, the pro-angiogenic factors produced by myeloma cells and the microenvironment, and the mechanisms involved in the myeloma-induced angiogenic switch. Current data s...

  6. Neutron source multiplication method

    Extensive use has been made of neutron source multiplication in thousands of measurements of critical masses and configurations and in subcritical neutron-multiplication measurements in situ that provide data for criticality prevention and control in nuclear materials operations. There is continuing interest in developing reliable methods for monitoring the reactivity, or k/sub eff/, of plant operations, but the required measurements are difficult to carry out and interpret on the far subcritical configurations usually encountered. The relationship between neutron multiplication and reactivity is briefly discussed and data presented to illustrate problems associated with the absolute measurement of neutron multiplication and reactivity in subcritical systems. A number of curves of inverse multiplication have been selected from a variety of experiments showing variations observed in multiplication during the course of critical and subcritical experiments where different methods of reactivity addition were used, with different neutron source detector position locations. Concern is raised regarding the meaning and interpretation of k/sub eff/ as might be measured in a far subcritical system because of the modal effects and spectrum differences that exist between the subcritical and critical systems. Because of this, the calculation of k/sub eff/ identical with unity for the critical assembly, although necessary, may not be sufficient to assure safety margins in calculations pertaining to far subcritical systems. Further study is needed on the interpretation and meaning of k/sub eff/ in the far subcritical system

  7. Strongly Multiplicative and 3-Multiplicative Linear Secret Sharing Schemes

    Zhang, Zhifang; Chee, Yeow Meng; Ling, San; Wang, Huaxiong; 10.1007/978-3-540-89255-7

    2008-01-01

    Strongly multiplicative linear secret sharing schemes (LSSS) have been a powerful tool for constructing secure multiparty computation protocols. However, it remains open whether or not there exist efficient constructions of strongly multiplicative LSSS from general LSSS. In this paper, we propose the new concept of a 3-multiplicative LSSS, and establish its relationship with strongly multiplicative LSSS. More precisely, we show that any 3-multiplicative LSSS is a strongly multiplicative LSSS, but the converse is not true; and that any strongly multiplicative LSSS can be efficiently converted into a 3-multiplicative LSSS. Furthermore, we apply 3-multiplicative LSSS to the computation of unbounded fan-in multiplication, which reduces its round complexity to four (from five of the previous protocol based on strongly multiplicative LSSS). We also give two constructions of 3-multiplicative LSSS from Reed-Muller codes and algebraic geometric codes. We believe that the construction and verification of 3-multiplicati...

  8. Multiple Sclerosis in Children

    Soroor INALOO

    2013-06-01

    Full Text Available How to Cite This Article: Inaloo S, Haghbin S. Multiple Sclerosis in Children. Iran J Child Neurol. 2013 Spring;7(2:1-10. Multiple sclerosis (MS is the most important immune-mediated demyelinated disease of human which is typically the disease of young adults. A total of 4% to 5% of MS population are pediatric. Pediatric MS is defined as the appearance of MS before the age of sixteen. About 80% of the pediatric cases and nearly all adolescent onset patients present with attacks typical to adult MS. Approximately 97% to 99% of the affected children have relapsing-remitting MS, while 85% to 95% of the adults experience such condition. MS in children is associated with more frequent and severe relapses. Treatment is the same as adults. We aimed to review the epidemiology, etiology, clinical manifestations, and treatment of MS in children. References1. Lublin F. History of modern multiple sclerosis therapy. J Neurol 2005 Sep;252(Suppl 3:iii3-iii9. Review.2. Murray TJ. Robert Carswell: the first illustrator of MS. Int MS J 2009 Sep;16(3:98-101.3. Kabat EA, Glusman M, Knaub V. Quantitative estimation of the albumin and gamma globulin in normal and pathologic cerebrospinal fluid by immunochemical methods. Am J Med 1948 May;4(5:653-62.4. Kumar DR, Aslinia F, Yale SH, Mazza JJ. Jean-Martin Charcot: the father of neurology. Clin Med Res 2011 Mar;9(1:46-9.5. Dawson JD. The histology of disseminated sclerosis.Trans of the Roy Soc Edinb. 1916;50:517-740.6. Gadoth N. Multiple sclerosis in children. Brain Dev 2003 Jun;25(4:229-32. Review.7. Banwell BL. Pediatric multiple sclerosis. Curr Neurol Neurosci Rep 2004 May;4(3:245-52.8. Renoux C, Vukusic S, Mikaeloff Y, Edan G, Clanet M, Dubois B, et al. Natural history of multiple sclerosis with childhood onset. N Engl J Med 2007 Jun 21;356(25:2603-13.9. Boiko A, Vorobeychicle G, Paty D, Devonshire V, Sondovnick D. Early onset multiple sclerosis: a long longitudinal study. Neurology 2002 Oct 8

  9. Multiplicities of dihedral discriminants

    Mayer, Daniel C.

    1992-04-01

    Given the discriminant {d_k} of a quadratic field k, the number of cyclic relative extensions N\\vert k of fixed odd prime degree p with dihedral absolute Galois group of order 2p, which share a common conductor f, is called the multiplicity of the dihedral discriminant {d_N} = {f^{2(p - 1)}}d_k^p . In this paper, general formulas for multiplicities of dihedral discriminants are derived by analyzing the p-rank of the ring class group mod f of k. For the special case p = 3,{d_k} = - 3 , an elementary proof is given additionally. The theory is illustrated by a discussion of all known discriminants of multiplicity ≥ 5 of totally real and complex cubic fields.

  10. High-multiplicity processes

    We wish to demonstrate that investigation of asymptotically high multiplicity (AHM) hadron reactions may solve, or at least clear up, a number of problems unsolvable by other ways. We would lean upon the idea: (i) the reactions final state entropy is proportional to multiplicity and, by this reason, just in the AHM domain one may expect the equilibrium final state and (ii) the AHM final state is cold because of the energy-momentum conservation laws. This means that the collective phenomena may become important in the AHM domain. The possibility of hard processes dominance is considered also

  11. Multiple Roles of Secretaries

    刘倩; 王姝濒; 赵柳

    2015-01-01

    The work of secretaries is very comprehensive and secretaries are key members of a company team.The study on the multiple roles of secretaries is not only about the theory but also about the practice.To understand and study the multiple roles of secretaries can strengthen secretaries’ ability of adaption and secretaries’ strain capacity.The purpose of this paper is to present a way of looking at the complexities of secretaries’ roles,and let secretaries have a better understanding of their roles to act out perfectly.

  12. Immunopathology of multiple sclerosis.

    Dendrou, Calliope A; Fugger, Lars; Friese, Manuel A

    2015-09-15

    Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future. PMID:26250739

  13. Multiple Roles of Secretaries

    刘倩; 王姝濒; 赵柳

    2015-01-01

    The work of secretaries is very comprehensive and secretaries are key members of a company team.The study on the multiple roles of secretaries is not only about the theory but also about the practice.To understand and study the multiple roles of secretaries can strengthen secretaries’ ability of adaption and secretaries’ strain capacity.The purpose of this paper is to present a way oflooking at the complexities of secretaries’ roles,and let secretaries have a better understanding of their roles to act out perfectly.

  14. Multiple origins of life

    Raup, D. M.; Valentine, J. W.

    1983-01-01

    There is some indication that life may have originated readily under primitive earth conditions. If there were multiple origins of life, the result could have been a polyphyletic biota today. Using simple stochastic models for diversification and extinction, we conclude: (1) the probability of survival of life is low unless there are multiple origins, and (2) given survival of life and given as many as 10 independent origins of life, the odds are that all but one would have gone extinct, yielding the monophyletic biota we have now. The fact of the survival of our particular form of life does not imply that it was unique or superior.

  15. Neutron multiplicity analysis tool

    Stewart, Scott L [Los Alamos National Laboratory

    2010-01-01

    I describe the capabilities of the EXCOM (EXcel based COincidence and Multiplicity) calculation tool which is used to analyze experimental data or simulated neutron multiplicity data. The input to the program is the count-rate data (including the multiplicity distribution) for a measurement, the isotopic composition of the sample and relevant dates. The program carries out deadtime correction and background subtraction and then performs a number of analyses. These are: passive calibration curve, known alpha and multiplicity analysis. The latter is done with both the point model and with the weighted point model. In the current application EXCOM carries out the rapid analysis of Monte Carlo calculated quantities and allows the user to determine the magnitude of sample perturbations that lead to systematic errors. Neutron multiplicity counting is an assay method used in the analysis of plutonium for safeguards applications. It is widely used in nuclear material accountancy by international (IAEA) and national inspectors. The method uses the measurement of the correlations in a pulse train to extract information on the spontaneous fission rate in the presence of neutrons from ({alpha},n) reactions and induced fission. The measurement is relatively simple to perform and gives results very quickly ({le} 1 hour). By contrast, destructive analysis techniques are extremely costly and time consuming (several days). By improving the achievable accuracy of neutron multiplicity counting, a nondestructive analysis technique, it could be possible to reduce the use of destructive analysis measurements required in safeguards applications. The accuracy of a neutron multiplicity measurement can be affected by a number of variables such as density, isotopic composition, chemical composition and moisture in the material. In order to determine the magnitude of these effects on the measured plutonium mass a calculational tool, EXCOM, has been produced using VBA within Excel. This

  16. Multiple snapshot compressive beamforming

    Gerstoft, Peter; Xenaki, Angeliki; Mecklenbrauker, Christoph F.;

    2015-01-01

    For sound fields observed on an array, compressive sensing (CS) reconstructs the multiple source signals at unknown directions-of-arrival (DOAs) using a sparsity constraint. The DOA estimation is posed as an underdetermined problem expressing the field at each sensor as a phase-lagged superposition...... of source amplitudes at all hypothetical DOAs. CS is applicable even for a single observation snapshot achieving a higher resolution than conventional beamforming. For multiple snapshots, CS outperforms conventional high-resolution methods, even with coherent arrivals and at low signal-to-noise ratio....

  17. Problems of multiple transfusions.

    GARDNER, F H

    1958-02-01

    The use of blood infusion in large amounts is increasing sharply. Increased knowledge of blood group antigens has alerted physicians to the possible hazards of hemolytic reactions to subgroups that must be eliminated by proper cross-matching techniques. Multiple transfusions of preserved blood often defeat their purpose in control of bleeding, for thrombocytopenia is enhanced. Careful selection of blood or preparations of plasma concentrates offer increased protection to the recipient.Plastic bag equipment increases the yield of viable platelets and keeps blood in usable condition for longer periods of storage. The use of multiple transfusions has complicated the selection of preserved blood to control pigment metabolism. PMID:13500210

  18. Computer-assisted lip diagnosis on traditional Chinese medicine using multi-class support vector machines

    Li FuFeng

    2012-08-01

    Full Text Available Abstract Background In Traditional Chinese Medicine (TCM, the lip diagnosis is an important diagnostic method which has a long history and is applied widely. The lip color of a person is considered as a symptom to reflect the physical conditions of organs in the body. However, the traditional diagnostic approach is mainly based on observation by doctor’s nude eyes, which is non-quantitative and subjective. The non-quantitative approach largely depends on the doctor’s experience and influences accurate the diagnosis and treatment in TCM. Developing new quantification methods to identify the exact syndrome based on the lip diagnosis of TCM becomes urgent and important. In this paper, we design a computer-assisted classification model to provide an automatic and quantitative approach for the diagnosis of TCM based on the lip images. Methods A computer-assisted classification method is designed and applied for syndrome diagnosis based on the lip images. Our purpose is to classify the lip images into four groups: deep-red, red, purple and pale. The proposed scheme consists of four steps including the lip image preprocessing, image feature extraction, feature selection and classification. The extracted 84 features contain the lip color space component, texture and moment features. Feature subset selection is performed by using SVM-RFE (Support Vector Machine with recursive feature elimination, mRMR (minimum Redundancy Maximum Relevance and IG (information gain. Classification model is constructed based on the collected lip image features using multi-class SVM and Weighted multi-class SVM (WSVM. In addition, we compare SVM with k-nearest neighbor (kNN algorithm, Multiple Asymmetric Partial Least Squares Classifier (MAPLSC and Naïve Bayes for the diagnosis performance comparison. All displayed faces image have obtained consent from the participants. Results A total of 257 lip images are collected for the modeling of lip diagnosis in TCM. The

  19. Multiple cystic swelling: Initial presentation of multiple myeloma

    Kumar Sunil; Jain A; Waghmare Swati

    2010-01-01

    Multiple myeloma, a disease allied to malignancy of reticuloendothelial cells, is not an uncommon condition. However, the diagnosis is often made quite late because the disease has multiple modes of presentation. We are reporting a case of multiple myeloma in a 55-year-old male who presented with multiple cystic swellings on the chest.

  20. The multiple Dirichlet product and the multiple Dirichlet series

    Onozuka, Tomokazu

    2016-01-01

    First, we define the multiple Dirichlet product and study the properties of it. From those properties, we obtain a zero-free region of a multiple Dirichlet series and a multiple Dirichlet series expression of the reciprocal of a multiple Dirichlet series.

  1. Multiple primary bronchogenic carcinomas.

    Yang, X; Ji, H; Paljarvi, L; Soimakallio, S

    1996-07-01

    Multiple primary bronchogenic carcinomas (MPBCa) are extremely rare. The differentiation of a MPBCa from a pulmonary metastasis due to an extrathoracic neoplasm is sometimes difficult. We reviewed 324 pathologically proved primary pulmonary carcinomas and found six cases of MPBCa (1.9%). We herewith present the series and discuss the diagnosis of MPBCa. PMID:21594435

  2. Multiple System Atrophy

    ... Order Brochures News From NINDS Funding Information Research Programs Training & Career Awards Enhancing Diversity Find People About NINDS Multiple System Atrophy Fact Sheet See a list of all NINDS Disorders Get Web page suited for printing Email this to a friend ...

  3. Multiple chemical sensitivity

    Tran, Marie Thi Dao; Arendt-Nielsen, Lars; Kupers, Ron;

    2013-01-01

    BACKGROUND: Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by recurrent, non-specific symptoms in response to chemically unrelated exposures in non-toxic concentrations. Although the pathophysiology of MCS remains unknown, central sensitization may be an important factor...

  4. Multiple Chemical Sensitivity

    Junge, Anne Gram

    Et voksende antal mennesker i Danmark oplever at være overfølsomme over for dufte og kemikalier. Imidlertid er den tilskrevne diagnose Multiple Chemical Sensitivity (MCS) ikke medicinsk anerkendt i Danmark pga. mangel på organiske og patofysiologisk basis for symptomerne. Dette speciale bygger på...

  5. Multiple Choriangiomas of Placenta

    Vijay Shankar S,

    2011-01-01

    Full Text Available Placental chorangiomas, not an uncommon condition is often small and hence usually goes unnoticed . However the incidence of complications is high when the chorangioma is large. We hereby present an unusual case of large and multiple choriangiomas with secondary changes and associated congenital anomalies with hydrops fetalis.

  6. Multiple Endocrine Neoplasia Syndromes

    ... type 2A disease. Almost everyone with type 2A disease develops medullary thyroid cancer (see Medullary cancer ). About 40 to ... stones in about 25% of people. Type 2B disease Multiple endocrine neoplasia type 2B can consist of Medullary thyroid cancer Pheochromocytomas Growths around nerves (neuromas) Many ...

  7. Multiple Cutaneous Reticulohistiocytoma

    Hemmady, Karishma D; Someshwar, Shylaja S; Jerajani, Hemangi R

    2016-01-01

    Multicentric reticulohistiocytosis is a rare non-Langerhans cell histiocytosis characterized in its full form by severe destructive arthritis, cutaneous nodules, and systemic manifestations. Cutaneous lesions may precede, accompany, or more commonly develop later than other features in this disease. We describe a case of multiple cutaneous reticulohistiocytoma without any systemic associations after thorough investigations. PMID:26955136

  8. Curability of Multiple Myeloma

    Raymond Alexanian

    2012-01-01

    Full Text Available Among 792 patients with multiple myeloma treated from 1987 to 2010 and assessed after 18 months, there were 167 patients with complete remission. For those 60 patients treated between 1987–1998 and with long followup, the latest relapse occurred after 11.8 years, so that 13 patients have remained in sustained complete remission for longer than 12 years (range 12–22 years. These results suggest that 3% of all patients treated during that period may be cured of multiple myeloma. In addition to immunofixation, more sensitive techniques for the detection of residual disease should be applied more consistently in patients with apparent complete remission in order to identify those with potential cure.

  9. Chronic progressive multiple sclerosis

    A long-lasting immunological suppression action seems to be produced by total lymphoid irradiation; some authors emphasize the favorable effect of this treatment on chronic progressive multiple sclerosis. In order to evaluate the actual role of TLI, 6 patients affected with chronic progressive multiple sclerosis were submitted to TLI with shaped and personalized fields at the Istituto del Radio, University of Brescia, Italy. The total dose delivered was 19.8 Gy in 4 weeks, 1.8 Gy/day, 5d/w; a week elapsed between the first and the second irradiation course. Disability according to Kurtzke scale was evaluated, together with blood lymphocyte count and irradiation side-effects, over a mean follow-up period of 20.8 months (range: 13-24). Our findings indicate that: a) disease progression was not markedly reduced by TLI; b) steroid hormones responsivity was restored after irradiation, and c) side-effects were mild and tolerable

  10. Formation of multiple networks

    Magnani, Matteo; Rossi, Luca

    2013-01-01

    While most research in Social Network Analysis has focused on single networks, the availability of complex on-line data about individuals and their mutual heterogenous connections has recently determined a renewed interest in multi-layer network analysis. To the best of our knowledge, in this paper...... we introduce the first network formation model for multiple networks. Network formation models are among the most popular tools in traditional network studies, because of both their practical and theoretical impact. However, existing models are not sufficient to describe the generation of multiple...... networks. Our model, motivated by an empirical analysis of real multi-layered network data, is a conservative extension of single-network models and emphasizes the additional level of complexity that we experience when we move from a single- to a more complete and realistic multi-network context....

  11. Multiple Peril Crop Insurance

    Edwards, William M.; Hofstrand, Donald

    2003-01-01

    Multiple Peril Crop Insurance (MPCI) is a broad-based crop insurance program regulated by the U.S. Department of Agriculture and subsidized by the Federal Crop Insurance Corporation(FCIC). Crops eligible for MPCI coverage in Iowa include corn, sobyeans, oats, wheat, seed corn, popcorn, barley, potatoes, sweet corn, canning beans, dry beans, forages, grain sorghum, green peas, tomatoes, and nursery stocks. Not all of these crops can be insured in all counties.

  12. Metamemory in multiple sclerosis

    Claffey, Austin M

    2010-01-01

    This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. The concept of metamemory proposes that supplementary to typically measured memory abilities, memory monitoring and control processes are used to optimise learning. Accurate memory monitoring appears to be underpinned by a range of cognitive, and possibly affective, contributions. In populations with these deficits, metamemory has been shown to be impaired. In Multiple Sclerosis (MS), only...

  13. Multiple cystic lung disease

    Flavia Angélica Ferreira Francisco; Arthur Soares Souza; Gláucia Zanetti; Edson Marchiori

    2015-01-01

    Multiple cystic lung disease represents a diverse group of uncommon disorders that can present a diagnostic challenge due to the increasing number of diseases associated with this presentation. High-resolution computed tomography of the chest helps to define the morphological aspects and distribution of lung cysts, as well as associated findings. The combination of appearance upon imaging and clinical features, together with extrapulmonary manifestations, when present, permits confident and a...

  14. Multiple correlation function approach

    Grebenkov, Denis S.

    2016-01-01

    The multiple correlation function approach is briefly presented and applied to investigate spin-echo signal attenuation due to restricted diffusion in simple geometries (slab, cylinder, and sphere) in the presence of surface relaxation. Exact and explicit representations for the zeroth and second moments of the total phase accumulated by diffusing spins are derived by using the Laplace transform summation technique. Within the Gaussian phrase approximation, these two moments determine the ...

  15. Multiple linear regression.

    Eberly, Lynn E

    2007-01-01

    This chapter describes multiple linear regression, a statistical approach used to describe the simultaneous associations of several variables with one continuous outcome. Important steps in using this approach include estimation and inference, variable selection in model building, and assessing model fit. The special cases of regression with interactions among the variables, polynomial regression, regressions with categorical (grouping) variables, and separate slopes models are also covered. Examples in microbiology are used throughout. PMID:18450050

  16. Albumin and multiple sclerosis

    LeVine, Steven M

    2016-01-01

    Leakage of the blood–brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination. Once in the CNS, albumin can participate in protective mechanisms. For example, due to its high concentration and molecular properties, albumin becomes a target for oxidation and nitration reactions. Furth...

  17. Multiple Hypotheses Video OCR

    Chen, Datong; Luettin, Juergen

    2000-01-01

    In this paper, we present a method to improve video OCR with multiple character hypotheses. The text regions in video need to be binarized before work as the input of current OCR system. Tranditional binarization do not use any structural information about the text. Based on a certain statistic model, we define a binarization method, which is called observation function, that should satisfy a certain condition. We then present a method to construct an observation function by computing binariz...

  18. Multiple plots in R

    Edwards, Stefan McKinnon

    2012-01-01

    In this chapter I will investigate how to combine multiple plots into a single. The scenario is a dataset of a series of measurements, on three samples in three situations. There are many ways we can display this, e.g. 3d graphs or faceting. 3d graphs are not good for displaying static data so we...... will not go there. Faceting is strictly speaking for plotting all variable / classes against each other....

  19. Multiples waveform inversion

    Zhang, D. L.

    2013-01-01

    To increase the illumination of the subsurface and to eliminate the dependency of FWI on the source wavelet, we propose multiples waveform inversion (MWI) that transforms each hydrophone into a virtual point source with a time history equal to that of the recorded data. These virtual sources are used to numerically generate downgoing wavefields that are correlated with the backprojected surface-related multiples to give the migration image. Since the recorded data are treated as the virtual sources, knowledge of the source wavelet is not required, and the subsurface illumination is greatly enhanced because the entire free surface acts as an extended source compared to the radiation pattern of a traditional point source. Numerical tests on the Marmousi2 model show that the convergence rate and the spatial resolution of MWI is, respectively, faster and more accurate then FWI. The potential pitfall with this method is that the multiples undergo more than one roundtrip to the surface, which increases attenuation and reduces spatial resolution. This can lead to less resolved tomograms compared to conventional FWI. The possible solution is to combine both FWI and MWI in inverting for the subsurface velocity distribution.

  20. Multiple organ procurement

    Vuković Milivoje

    2007-01-01

    Full Text Available Introduction. Liver transplantation is the most demanding of all solid organ transplantations. It requires perfect organization and motivation of health care professionals, patients and their families. This article deals with the procedure for multiple organ procurement, reviews criteria for organ donation and describes the surgical technique for multiple organ procurement. Discussion. Adequate selection and evaluation of cadaveric donors and of organs for transplantation should include early identification of potential donors, and early diagnosis of brain death. The procurement of the highest number of viable organs for transplantation requires excellence in each of the phases. Early and aggressive physiologic support in the maintenance of potential donors can reduce organ donor loss due to irreversible asystole or multiorgan failure (it is almost always possible to maintain organ perfusion pressure and increase the number of organs without increasing post-transplant morbidity or mortality. The ideal donor is a young, previously healthy, brain dead, victim of an accident. Conclusion. The surgical procedure for multiple organ procurement from brain death donors must be performed without intraopertive organ damage. .

  1. Multiple myeloma: 45 cases

    We evaluated 45 cases of multiple myelomas retrospectively confirmed in Severance Hospital from the period of 1983-1989. In order to assess the radiologic features of the multiple myeloma and to assist in possible early diagnosis and treatment. The result were as follows: 1. IgG(41%) was the most common immunoglobulin type secreted followed by light chain(36%). IgA(19%) and IgD(2%). Two percent of the patients had non-secretory type. 89% of patients were in their stage III of the disease. 2. Among the 45 patients, 96% had abnormal plain radiographic findings with average number of 4.5 lesions. Common sites were the spine, rib, skull, pelvis, and humerus in descending orders. The findings were localized or diffuse osteolytic bone destruction(85%). osteoporosis(49%), pathologic fracture and endosteal scalloping(55%). Osteoporosis was more prominent in stage III than stage II. 3. Both plain X-ray and radioisotope study was available for comparison in 28 patients. Concordance between the two studies were 44%, lesions detected only on plain X-ray film were 51%, and lesions detected only on the radioisotope were 5%. The plain radiography was able to detect only 54% of bone lesions confirmed by bone marrow biopsy. With the above results, accurate evaluation of bone lesions in multiple myeloma may be difficult with radiologic studies only. But familiarity with these radiologic findings of the this disease entity is necessary for early suspicion of the disease, thus for early diagnosis and treatment

  2. Multiple constant multiplication optimizations for field programmable gate arrays

    Kumm, Martin

    2016-01-01

    This work covers field programmable gate array (FPGA)-specific optimizations of circuits computing the multiplication of a variable by several constants, commonly denoted as multiple constant multiplication (MCM). These optimizations focus on low resource usage but high performance. They comprise the use of fast carry-chains in adder-based constant multiplications including ternary (3-input) adders as well as the integration of look-up table-based constant multipliers and embedded multipliers to get the optimal mapping to modern FPGAs. The proposed methods can be used for the efficient implementation of digital filters, discrete transforms and many other circuits in the domain of digital signal processing, communication and image processing. Contents Heuristic and ILP-Based Optimal Solutions for the Pipelined Multiple Constant Multiplication Problem Methods to Integrate Embedded Multipliers, LUT-Based Constant Multipliers and Ternary (3-Input) Adders An Optimized Multiple Constant Multiplication Architecture ...

  3. Quantum Interference of Multiple Beams Induced by Multiple Scattering

    Ott, Johan Raunkjær; Mortensen, N. Asger; Lodahl, Peter

    2011-01-01

    We report on quantum interference induced by the transmission of quantized light through a multiple-scattering medium. We show that entangled states can be created by multiple-scattering and that quantum interference survives disorder averaging.......We report on quantum interference induced by the transmission of quantized light through a multiple-scattering medium. We show that entangled states can be created by multiple-scattering and that quantum interference survives disorder averaging....

  4. Multiple Sparse Representations Classification.

    Plenge, Esben; Klein, Stefan; Klein, Stefan S; Niessen, Wiro J; Meijering, Erik

    2015-01-01

    Sparse representations classification (SRC) is a powerful technique for pixelwise classification of images and it is increasingly being used for a wide variety of image analysis tasks. The method uses sparse representation and learned redundant dictionaries to classify image pixels. In this empirical study we propose to further leverage the redundancy of the learned dictionaries to achieve a more accurate classifier. In conventional SRC, each image pixel is associated with a small patch surrounding it. Using these patches, a dictionary is trained for each class in a supervised fashion. Commonly, redundant/overcomplete dictionaries are trained and image patches are sparsely represented by a linear combination of only a few of the dictionary elements. Given a set of trained dictionaries, a new patch is sparse coded using each of them, and subsequently assigned to the class whose dictionary yields the minimum residual energy. We propose a generalization of this scheme. The method, which we call multiple sparse representations classification (mSRC), is based on the observation that an overcomplete, class specific dictionary is capable of generating multiple accurate and independent estimates of a patch belonging to the class. So instead of finding a single sparse representation of a patch for each dictionary, we find multiple, and the corresponding residual energies provides an enhanced statistic which is used to improve classification. We demonstrate the efficacy of mSRC for three example applications: pixelwise classification of texture images, lumen segmentation in carotid artery magnetic resonance imaging (MRI), and bifurcation point detection in carotid artery MRI. We compare our method with conventional SRC, K-nearest neighbor, and support vector machine classifiers. The results show that mSRC outperforms SRC and the other reference methods. In addition, we present an extensive evaluation of the effect of the main mSRC parameters: patch size, dictionary size, and

  5. Distributed multiple description coding

    Bai, Huihui; Zhao, Yao

    2011-01-01

    This book examines distributed video coding (DVC) and multiple description coding (MDC), two novel techniques designed to address the problems of conventional image and video compression coding. Covering all fundamental concepts and core technologies, the chapters can also be read as independent and self-sufficient, describing each methodology in sufficient detail to enable readers to repeat the corresponding experiments easily. Topics and features: provides a broad overview of DVC and MDC, from the basic principles to the latest research; covers sub-sampling based MDC, quantization based MDC,

  6. The Border Multiple

    of European borders by looking at border practices in the light of the mobility turn, and thus as dynamic, multiple, diverse and best expressed in everyday experiences of people living at and with borders, rather than focusing on static territorial divisions between states and regions at geopolitical...... level. It provides border scholars and researchers as well as policymakers with new empirical and theoretical evidence on the de- and re-bordering processes going on in diverse border regions in Europe, both within and outside of the EU....

  7. Multiple-pass reflectometer

    Edwards, D.F. (Los Alamos National Lab., NM); Baumeister, P.

    1981-11-15

    The multiple-pass reflectometer has been shown to be a convenient and precise instrument for measuring absolute spectral reflectance values in excess of 0.99. Given here is an extension of earlier work. We present details of the setup, operation, parameter optimization, and some limitations of the reflectometer. For a carefully aligned instrument the precision of the measurement is limited by the uncertainty in the computer fit of a straight line to the data. For the uv and visible spectral regions, typical reflectance precision is a few parts in 10/sup 4/. Systematic errors due to nonuniform photosurfaces and astigmatism have been minimized for the setup described here.

  8. Aid with Multiple Personalities

    Djankov, Simeon; Jose G. Montalvo; Reynal-Querol, Marta

    2009-01-01

    The existing research on foreign aid offers inconclusive evidence on the factors that make aid effective. In this paper, we study the supply of aid money in 112 developing countries over the period 1960-1999 and find that the presence of multiple donors in a given country renders aid less effective. In particular, an aid-receiving country at the median of the donor fractionalization distribution will grow one percentage point faster than a country at the 75th percentile. This is in part becau...

  9. Relighting multiple color textures

    DIAO Chang-yu; LU Dong-ming; LIU Gang

    2005-01-01

    With the development of digital library technology, library books made of paper can be digital released and read, and Endangered Cultural Heritages can be preserved. Traditional library's contents and functions can be greatly enhanced by digital technologies. For these new library objects, the primary key problem is precisely reconstructing their 3D models. When constructing complete 3D models, multiple color texture maps are often necessary. A commonly encountered problem uncounted during fusing of textures from multiple color images is color distortion. Each texture of a single 3D model may be obtained under possibly different lighting conditions and color response of the camera. To remove any visible seam and improve color consistency between the textures while avoiding color distortion, we propose a new efficient algorithm to relight all the texture images globally,spread residual light difference, and recolor each image by homogeneous transformation. A relative illumination model was adopted to obtain the relighting function. We choose lαβ color space with minimal correlation between channels for many natural scenes, for calculating the relighting result. Looking into two overlapped images A and B, we can pairwise relight B into A's luminosity condition in two steps. We first scale B's l channel by the lA/lB ratio of the overlapped region. We can assume A and B are in a same color plane now. Then a homogeneous transformation is applied to B's α and β channels which moves B into A's hue and saturation condition. For multiple overlapped color textures, a patch based weighted global relighting method was proposed to minimize the total color difference. The pairwise relighting method was used between each two overlapped images, and the difference in every overlapped region after relighting was weighted and summed up to construct an energy value. We used Nelder-Mead method to find a minimal energy value and the relighting parameters for every image. After

  10. Ordering, materiality and multiplicity

    van der Duim, René; Ren, Carina Bregnholm; Jóhannesson, Gunnar Thór

    2013-01-01

    In this article we discuss how ANT has been translated into tourism research and show how it has impacted the field by presenting three concepts integral to the ANT approach: ordering, materiality and multiplicity. We first introduce ANT and draw attention to current ANT studies in tourism......, followed by a discussion of how newer approaches within post-ANT urge us to face the ontological politics, which we engage in when performing tourism research. In conclusion we argue that ANT enables a radical new way at looking at tourism, tourism destinations and objects and investigations into the...... ontological condition of tourism....

  11. Fault Detection and Diagnosis in Process Data Using Support Vector Machines

    Fang Wu

    2014-01-01

    Full Text Available For the complex industrial process, it has become increasingly challenging to effectively diagnose complicated faults. In this paper, a combined measure of the original Support Vector Machine (SVM and Principal Component Analysis (PCA is provided to carry out the fault classification, and compare its result with what is based on SVM-RFE (Recursive Feature Elimination method. RFE is used for feature extraction, and PCA is utilized to project the original data onto a lower dimensional space. PCA T2, SPE statistics, and original SVM are proposed to detect the faults. Some common faults of the Tennessee Eastman Process (TEP are analyzed in terms of the practical system and reflections of the dataset. PCA-SVM and SVM-RFE can effectively detect and diagnose these common faults. In RFE algorithm, all variables are decreasingly ordered according to their contributions. The classification accuracy rate is improved by choosing a reasonable number of features.

  12. Pediatric Multiple Sclerosis.

    Lee, Ji Y; Chitnis, Tanuja

    2016-04-01

    Pediatric multiple sclerosis (MS) is a chronic inflammatory neurologic disease that is challenging to diagnose and treat. Although there are many clinical parallels between pediatric-onset MS and adult-onset MS, there is also accumulating evidence of distinguishing clinical features that may, in part, arise from development-specific, neuroimmune processes governing MS pathogenesis in children. Here the authors describe the clinical features, diagnosis, and treatment of pediatric MS, with a particular focus on describing clinical features and highlighting new developments that promise a better understanding of pediatric MS pathogenesis. An important task that lies ahead for pediatric neurologists is better understanding the early gene-environment interaction that precipitates the first demyelinating event in pediatric MS. This area is of particular importance for understanding the MS etiology and the natural history of pediatric MS. Such understanding should in turn inform new developments in diagnostic tools, long-term therapies, and much-needed biomarkers. Such biomarkers are not only valuable for defining the disease onset, but also for monitoring both the treatment response and a disease evolution that spans multiple decades in children with MS. PMID:27116721

  13. Smoldering Multiple Myeloma

    Minjie Gao

    2015-01-01

    Full Text Available Smoldering multiple myeloma (SMM is an asymptomatic precursor stage of multiple myeloma (MM characterized by clonal bone marrow plasma cells (BMPC ≥ 10% and/or M protein level ≥ 30 g/L in the absence of end organ damage. It represents an intermediate stage between monoclonal gammopathy of undetermined significance (MGUS and symptomatic MM. The risk of progression to symptomatic MM is not uniform, and several parameters have been reported to predict the risk of progression. These include the level of M protein and the percentage of BMPC, the proportion of immunophenotypically aberrant plasma cells, and the presence of immunoparesis, free light-chain (FLC ratio, peripheral blood plasma cells (PBPC, pattern of serum M protein evolution, abnormal magnetic resonance imaging (MRI, cytogenetic abnormalities, IgA isotype, and Bence Jones proteinuria. So far treatment is still not recommended for SMM, because several trials suggested that patients with SMM do not benefit from early treatment. However, the Mateos et al. trial showed a survival benefit after early treatment with lenalidomide plus dexamethasone in patients with high-risk SMM. This trial has prompted a reevaluation of early treatment in an asymptomatic patient population.

  14. Tuberous Sclerosis: Multiple Presentations

    M. Sanei Taheri

    2008-01-01

    Full Text Available Introduction: Tuberous sclerosis is an autosomal do-minant genetic disorder that involves multiple or-gans. The predominant lesions are the hamartomas. Classically tuberous sclerosis has been characterized by a classic clinical triad of facial angiofibromas in 90%,retardation in 50-80%,seizure 80-90% and all three in 30%."nThe disease occurs in 1:100,000 persons in all races with nearly equal distribution between the sexes. "nCase Presentation: We had six patients who admitted with different presentations of tuberous sclerosis with a past history of convulsion from childhood, skin le-sions and mental retardation, also with new onset headache and changed pattern of convulsion. In physical examination facial angiofibromas and sub-ungual fibromas apparently detected. Brain CT scan study with contrast showed multiple calcified nod-ules associated with tubers and ventriculomegaly, also an enhancing enlarged nodule at foramen of mo-nro, which was suggestive of subependymal giant cell astrocytoma (SGCA. In abdominal and pelvic CT scan and ultrasonography, massive bilateral angio-myolipomatosis diagnosed. Also Focal hypodense le-sions in liver which were hyperechoic in ultrasono-graphy were diagnosed. With MRI study tubers, white matter lesions and subependymal nodules asso-ciated with SGCA were detected better. After surgery SGCA was proved."nDiscussion: Our patients had different presentations and various findings of this spectrum discussed in this lecture.

  15. Albumin and multiple sclerosis.

    LeVine, Steven M

    2016-01-01

    Leakage of the blood-brain barrier (BBB) is a common pathological feature in multiple sclerosis (MS). Following a breach of the BBB, albumin, the most abundant protein in plasma, gains access to CNS tissue where it is exposed to an inflammatory milieu and tissue damage, e.g., demyelination. Once in the CNS, albumin can participate in protective mechanisms. For example, due to its high concentration and molecular properties, albumin becomes a target for oxidation and nitration reactions. Furthermore, albumin binds metals and heme thereby limiting their ability to produce reactive oxygen and reactive nitrogen species. Albumin also has the potential to worsen disease. Similar to pathogenic processes that occur during epilepsy, extravasated albumin could induce the expression of proinflammatory cytokines and affect the ability of astrocytes to maintain potassium homeostasis thereby possibly making neurons more vulnerable to glutamate exicitotoxicity, which is thought to be a pathogenic mechanism in MS. The albumin quotient, albumin in cerebrospinal fluid (CSF)/albumin in serum, is used as a measure of blood-CSF barrier dysfunction in MS, but it may be inaccurate since albumin levels in the CSF can be influenced by multiple factors including: 1) albumin becomes proteolytically cleaved during disease, 2) extravasated albumin is taken up by macrophages, microglia, and astrocytes, and 3) the location of BBB damage affects the entry of extravasated albumin into ventricular CSF. A discussion of the roles that albumin performs during MS is put forth. PMID:27067000

  16. Multiple Intelligences and quotient spaces

    Malatesta, Mike; Quintana, Yamilet

    2006-01-01

    The Multiple Intelligence Theory (MI) is one of the models that study and describe the cognitive abilities of an individual. In [7] is presented a referential system which allows to identify the Multiple Intelligences of the students of a course and to classify the level of development of such Intelligences. Following this tendency, the purpose of this paper is to describe the model of Multiple Intelligences as a quotient space, and also to study the Multiple Intelligences of an individual in...

  17. Multiplicative Runge-Kutta Methods

    Aktöre, Hatice

    2011-01-01

    ABSTRACT: In this thesis the multiplicative Runge-Kutta Method is developed employing the idea of the ordinary Runge-Kutta Method to multiplicative calculus. The multiplicative Runge-Kutta Methods for the orders 2,3, and 4 are developed and discussed. The developed algorithms are applied to examples where the solutions of the Ordinary Differential Equations are known. This gives the opportunity to check the relative error of the calculation reliably. The results in the multiplicative case are...

  18. Neurogenic Bladder and Multiple Sclerosis

    Krupin V.N.

    2011-12-01

    Full Text Available There have been presented general information of neurogenic bladder and the data on pathophysiology of lower urinary tract dysfunction in patients with multiple sclerosis. The characteristics of clinical presentations of neurogenic bladder in multiple sclerosis have been stated. There have been considered diagnosis and treatment problems of urinary disorders in patients with multiple sclerosis.

  19. Multiple myeloma with lung plasmacytoma

    Rajendra Prasad; Sanjay Kumar Verma; Rakhi Sodhi

    2011-01-01

    Malignant myeloma (MM) is a clonal proliferation of plasma cells with multiple osteolytic lesions. Extramedullary dissemination of multiple myeloma in lung is relatively uncommon. Hereby, we present a case of multiple myeloma with lung plasmacytoma of lung in a 45-years-old, non-smoker, female.

  20. Dihedral symmetries of multiple logarithms

    Agarwala, Susama

    2011-01-01

    This paper finds relationships between multiple logarithms with a dihedral group action on the arguments. I generalize the combinatorics developed in Gangl, Goncharov and Levin's R-deco polygon representation of multiple logarithms to find these relations. By writing multiple logarithms as iterated integrals, my arguments are valid for iterated integrals as over an arbitrary field.

  1. Networks amid multiple logics

    Bergenholtz, Carsten; Bjerregaard, Toke

    The present study investigates how a high-tech-small-firm (HTSF) can carry out an inter-organizational search of actors located at universities. Responding to calls to study how firms navigate multiple institutional norms, this research examines the different strategies used by a HTSF to balance...... adopted academic norm-sets, commercial imperatives and formal regulations to support formation of networks and collaborations with universities. The findings show how the significance of weak and strong ties for the formation of collaborations and networks with universities is relative to the...... institutional embeddedness in different industries. The research thus illuminates how a HTSF effectively can combine different search and collaboration strategies depending on institutional contexts and logics governing R&D work. The concluding section outlines implications for future research and the...

  2. Media and Multiplicity

    Blaagaard, Bolette

    2010-01-01

    Danish cartoon controversy, and Dutch politician Geert Wilders’s film, Fitna. Simultaneously, however, the media is more diverse and rhizomatic than ever and offers potential for cosmopolitanism, transnational ethical relations as well as radical anti-racist and anti-fascist interventions. This article......In the past few years continental Europe has experienced a resurgence of right-wing party politics, nationalism and xenophobia. In this nationalist revival the media and advanced communications technologies have played a significant role, as evidenced by the debates following cases such as the...... explores the tensions within the relation between journalistic practice and the construction of the idea of the nation and the multiplicity of media and cultures which inhabit the spheres of journalism and nation....

  3. Multiple detectors "Influence Method".

    Rios, I J; Mayer, R E

    2016-05-01

    The "Influence Method" is conceived for the absolute determination of a nuclear particle flux in the absence of known detector efficiency and without the need to register coincidences of any kind. This method exploits the influence of the presence of one detector in the count rate of another detector, when they are placed one behind the other and define statistical estimators for the absolute number of incident particles and for the efficiency (Rios and Mayer, 2015a). Its detailed mathematical description was recently published (Rios and Mayer, 2015b) and its practical implementation in the measurement of a moderated neutron flux arising from an isotopic neutron source was exemplified in (Rios and Mayer, 2016). With the objective of further reducing the measurement uncertainties, in this article we extend the method for the case of multiple detectors placed one behind the other. The new estimators for the number of particles and the detection efficiency are herein derived. PMID:26943904

  4. Quantum Optical Multiple Scattering

    Ott, Johan Raunkjær

    for the dipoles while treating them as quantum two-level systems and using the Born–Markov and rotating-wave approximations. Postponing the rotating-wave approximation to the very end of the formal calculations allows us to identify the different physical parameters of the dipole evolution in terms of...... first part we use a scattering-matrix formalism combined with results from random-matrix theory to investigate the interference of quantum optical states on a multiple scattering medium. We investigate a single realization of a scattering medium thereby showing that it is possible to create entangled...... states by interference of squeezed beams. Mixing photon states on the single realization also shows that quantum interference naturally arises by interfering quantum states. We further investigate the ensemble averaged transmission properties of the quantized light and see that the induced quantum...

  5. Multiple part feeding

    Hvilshøj, Mads; Bøgh, Simon; Nielsen, Oluf Skov;

    2012-01-01

    Purpose - The purpose of this paper is to present experience from a real-world demonstration of autonomous industrial mobile manipulation (AIMM) based on the mobile manipulator "Little Helper" performing multiple part feeding at the pump manufacturer Grundfos A/S. Design/methodology/approach - The...... necessary AIMM technologies exist at a mature level - the reason that no mobile manipulators have yet been implemented in industrial environments, is that research in the right applications have not been carried out. We propose a pragmatic approach consisting of: a commercial-off-the-shelf (COTS) mobile....... Originality/value - The paper presents a full-scale demonstration of a state-of-the-art COTS autonomous mobile manipulator system with particular focus on industrial utilization and application....

  6. Reduced Multiplication Modules

    Karim Samei

    2011-05-01

    An -module is called a multiplication module if for each submodule of , = for some ideal of . As defined for a commutative ring , an -module is said to be reduced if the intersection of prime submodules of is zero. The prime spectrum and minimal prime submodules of the reduced module are studied. Essential submodules of are characterized via a topological property. It is shown that the Goldie dimension of is equal to the Souslin number of Spec (). Also a finitely generated module is a Baer module if and only if Spec () is an extremally disconnected space; if and only if it is a -module. It is proved that a prime submodule is minimal in if and only if for each $x\\in N,\\mathrm{Ann}(x)\

  7. Multiple Commutator Formulas

    Hazrat, R.; Zhang, Z.

    2011-01-01

    Let A be a quasi-finite R-algebra (i.e., a direct limit of module finite algebras) with identity. Let I_i, i=0,...,m, be two-sided ideals of A, \\GL_n(A,I_i) the principal congruence subgroup of level I_i in GL_n(A) and E_n(A,I_i) be the relative elementary subgroup of level I_i. We prove a multiple commutator formula [E_n(A,I_0),\\GL_n(A,I_1),& \\GL_n(A, I_2),..., \\GL_n(A, I_m)] = [E_n(A,I_0),E_n(A,I_1),E_n(A, I_2),..., E_n(A, I_m)], which is a broad generalization of the standard commutator fo...

  8. Multiple gas reduction strategy

    A. Kurosawa [Institute of Applied Energy, Tokyo (Japan)

    2003-07-01

    Future global warming has a close relationship with the abatement potential of six greenhouse gases (GHGs), including carbon dioxide (CO{sub 2}), methane (CH{sub 4}), nitrous oxide (N{sub 2}O), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), and sulfur hexafluoride (SF6). Therefore, multiple gas reduction flexibility should be assessed. The emission of each non-CO{sub 2} GHG is calculated endogenously by the sum of the product of the emission factor and the endogenous activity index using an integrated assessment model, GRAPE (Global Relationship Assessment to Protect the Environment). The model consists of five modules dealing with issues on energy, climate, land use, macroeconomics and environmental impacts. The uncertainty in the non-CO{sub 2} GHG emission inventory and emission factors is discussed. 5 refs., 3 figs., 1 tab.

  9. Swamp Works- Multiple Projects

    Carelli, Jonathan M.; Schuler, Jason M.; Chandler, Meredith L.

    2013-01-01

    My Surface Systems internship over the summer 2013 session covered a broad range of projects that utilized multiple fields of engineering and technology. This internship included a project to create a command center for a 120 ton regolith bin, for the design and assembly of a blast shield to add further protection for the Surface Systems engineers, for the design and assembly of a portable four monitor hyper wall strip that could extend as large as needed, research and programming a nano drill that could be utilized on a next generation robot or rover, and social media tasks including the making of videos, posting to social networking websites and creation of a new outreach program to help spread the word about the Swamp Works laboratory.

  10. Multiple Differential Aperture Microscopy

    Differential-aperture X-ray microscopy (DAXM) is a powerful approach to 3D tomography with particular relevance to X-ray microdiffraction. With DAXM, scattering from submicron volumes can be resolved. However, the method is intrinsically a scanning technique where every resolved volume element (voxel) requires at least one area-detector readout. Previous applications of DAXM have used a single wire for knife-edge step profiling. Here, we demonstrate a way to accelerate DAXM measurements using multiple wires. A proof-of-principle experiment with a three-wire prototype showed that the speed of measurements can be tripled, but careful calibrations of wires will be required to maintain the spatial accuracy. In addition, related possibilities for accelerating measurements are briefly discussed

  11. Multiple Turbine Wakes

    Machefaux, Ewan; Mann, Jakob

    The central goal of the present research was to study single and multiple interacting wind turbine wakes using both full-scale lidar experiments and high fidelity CFD numerical approaches.Firstly, single wake dynamics have been studied experimentally using full-scale (nacelle based) pulsed lidar......, the Bulk-Richardson and the Froude number approach. Three test cases are subsequently defined covering various atmospheric conditions. Simulations based on the EllipSys3D ABL flow solver are carried out using Large Eddy Simulation and Actuator disc rotor modeling.The turbulence properties of the incoming...... lidars. A thorough analysis and interpretation of the measurements was performed to overcome either the lack or the poor calibration of relevant turbine operational sensors, as well as other uncertainties inherent to wake resolving from full-scale experiments. The numerical work was based on the in...

  12. MULTIPLE GALAXY COLLISIONS

    2002-01-01

    Here is a sampling of 15 ultraluminous infrared galaxies viewed by NASA's Hubble Space Telescope. Hubble's sharp vision reveals more complexity within these galaxies, which astronomers are interpreting as evidence of a multiple-galaxy pileup. These images, taken by the Wide Field and Planetary Camera 2, are part of a three-year study of 123 galaxies within 3 billion light-years of Earth. The study was conducted in 1996, 1997, and 1999. False colors were assigned to these photos to enhance fine details within these coalescing galaxies. Credits: NASA, Kirk Borne (Raytheon and NASA Goddard Space Flight Center, Greenbelt, Md.), Luis Colina (Instituto de Fisica de Cantabria, Spain), and Howard Bushouse and Ray Lucas (Space Telescope Science Institute, Baltimore, Md.)

  13. Multiple stage railgun

    A multiple stage magnetic railgun accelerator for accelerating a projectile by movement of a plasma arc along the rails. The railgun is divided into a plurality of successive rail stages which are sequentially energized by separate energy sources as the projectile moves through the bore of the railgun. Propagation of energy from an energized rail stage back towards the breech end of the railgun can be prevented by connection of the energy sources to the rails through isolation diodes. Propagation of energy from an energized rail stage back towards the breech end of the railgun can also be prevented by dividing the rails into electrically isolated rail sections. In such case means are used to extinguish the arc at the end of each energized stage and a fuse or laser device is used to initiate a new plasma arc in the next energized rail stage

  14. Metabolomics in multiple sclerosis.

    Bhargava, Pavan; Calabresi, Peter A

    2016-04-01

    Multiple sclerosis (MS) is a chronic demyelinating disorder of the central nervous system with inflammatory and degenerative components. The cause of MS remains unknown although genetic and environmental factors appear to play a role in its etiopathogenesis. Metabolomics is a new "omics" technology that aims at measuring small molecules in various biological matrices and can provide information that is not readily obtained from genomics, transcriptomics, or proteomics. Currently, several different analytical platforms exist for metabolomics, and both untargeted and targeted approaches are being employed. Methods of analysis of metabolomics data are also being developed and no consensus currently exists on the optimal approach to analysis and interpretation of these data. Metabolomics has the potential to provide putative biomarkers, insights into the pathophysiology of the disease, and to aid in precision medicine for patients with MS. PMID:26754801

  15. On Multiple Appearances

    Bork Petersen, Franziska

    2012-01-01

    reduction and epoché to focus on how dancing bodies appear in a stage context. To test these tools’ ability to explore dancing bodies from a third-person perspective, I analyse the Danish choreographer Kitt Johnson’s solo performance Drift (2011) - focussing on her shifting physical appearance. While...... phenomenology helps me to describe the multiple and radically different guises that Johnson assumes in her piece, my analysis, ultimately, does not aim to distil a truer, more real being from her appearances as is often the case in phenomenological philosophy. I complement my analytical approach...... with the Deleuzian notion of becoming animal and suggest that Johnson stages what could, in Judith Butler’s terms, be called a critical contingency of bodily appearance....

  16. Anthropology and Multiple Modernities

    Thomassen, Bjørn

    “modernities” over the last 10 years, this paper wishes to address the analytical usefulness of this conceptual development. What is it about these concepts that make them useful as we try to capture the World today? Rather than providing any substantial definitions as to what those modernities are about (or...... what they are not about), anthropologists have used ethnographies to demonstrate how modernities are lived and constructed differently in different cultural contexts. To a very large extent, anthropologists intend these multiple modernities to refer to the interplay between local and global...... configurations. However, if the current pluralizing of modernity ultimately serves to describe the variety of cultural forms that co-exist in the World today, the analytical value of the concept risks being watered down, and little is gained in perspective. Arguably, other concepts would have served the purpose...

  17. Analysis of multiple source/multiple informant data in Stata

    Nicholas Horton; Garrett Fitzmaurice

    2005-01-01

    We describe regression-based methods for analyzing multiple-source data arising from complex sample survey designs in Stata. We use the term multiple-source data to encompass all cases where data are simultaneously obtained from multiple informants, or raters (e.g., self-reports, family members, health care providers, administrators) or via different/parallel instruments, indicators or methods (e.g., symptom rating scales, standardized diagnostic interviews, or clinical diagnoses). We review ...

  18. Multiple exostotic hypochondroplasia: Syndrome of combined hypochondroplasia and multiple exostoses

    This is a report of a family with major focus on the daughter who had short stature. The mother had hypochondroplasia and the father had multiple exostoses. The daughter's skeletal roentgenograms show features of both hypochondroplasia and multiple exostoses. The roentgenographic, clinical and genetic aspects of these skeletal dysplasias are reviewed and hypochrondroplasia is contrasted with achondroplasia. The genetic and counseling implications of the association of hypochondroplasia and multiple exostoses are discussed. (orig.)

  19. Multiple exostotic hypochondroplasia: Syndrome of combined hypochondroplasia and multiple exostoses

    Dominguez, R.; Young, L.W.; Girdany, B.R.; Steele, M.W.

    1984-07-01

    This is a report of a family with major focus on the daughter who had short stature. The mother had hypochondroplasia and the father had multiple exostoses. The daughter's skeletal roentgenograms show features of both hypochondroplasia and multiple exostoses. The roentgenographic, clinical and genetic aspects of these skeletal dysplasias are reviewed and hypochrondroplasia is contrasted with achondroplasia. The genetic and counseling implications of the association of hypochondroplasia and multiple exostoses are discussed.

  20. Continuous Multiple Vertebral Compression Fractures in Multiple Myeloma Patient

    Hong, Sang Moon; Kim, Tae Wan; Park, Kwan Ho

    2012-01-01

    Multiple myeloma is a B-cell origin tumor characterized by hypercalcemia, osteolytic bony lesions, and pathologic fractures. Back pain is one of the most common presenting symptoms of multiple myeloma and about 60% of patients have vertebral involvement at the time of diagnosis7). Minimally invasive surgeries such as vertebroplasty and kyphoplasty are effective to relieve pain and improve the quality of life when a compression fracture occurs in multiple myeloma patients. We report a case of ...

  1. Erasure Multiple Descriptions

    Ahmed, Ebad

    2010-01-01

    We consider a binary erasure version of the n-channel multiple descriptions problem with symmetric descriptions, i.e., the rates of the n descriptions are the same and the distortion constraint depends only on the number of messages received. We consider the case where there is no excess rate for every k out of n descriptions. Our goal is to characterize the achievable distortions D_1, D_2,...,D_n. We measure the fidelity of reconstruction using two distortion criteria: an average-case distortion criterion, under which distortion is measured by taking the average of the per-letter distortion over all source sequences, and a worst-case distortion criterion, under which distortion is measured by taking the maximum of the per-letter distortion over all source sequences. We present achievability schemes, based on random binning for average-case distortion and systematic MDS (maximum distance separable) codes for worst-case distortion, and prove optimality results for the corresponding achievable distortion region...

  2. Writing on Multiple Journeys

    Sarah Robbins

    2012-06-01

    Full Text Available In their beautifully researched study and critical edition, Nellie Arnott’s Writings on Angola, 1905–1913: Missionary Narratives Linking Africa and America (Parlor Press, authors Sarah Robbins and Ann Ellis Pullen examine in fine detail the historical record of the transnational network of literary work produced by Arnott. Tracing her legacy in the study’s third chapter, “Writing on Multiple Journeys,” the authors argue on behalf of Arnott’s capacity to create authority and celebrity as well as a sense of community among her distant readers, underscoring the powerful and influential role that missionary women’s writing (mimicking to some extent the popular genre of travel writing played in shaping attitudes at home, not only with regard to race, but also in relation to women’s roles, place, and purpose. Robbins and Pullen display a conscientious resolve not to obscure the inherent contradictions in Arnott’s changing perspectives as they offer a historical narrative based on Arnott’s public and private texts, which also reveal the “consistent inconsistency” in her attitudes and beliefs. Details of and insights into educational practices in missionary schools, including the observation that mothers in the US appreciated the fact that their middle-class Christian children were sharing curriculum with Umbundu children in Angola, invite interesting conclusions about the transnational, transgenerational, and gendered effects of women’s work in the missionary world.

  3. [Congenital multiple arthrogryposis].

    Parsch, Klaus; Pietrzak, Szymon

    2007-03-01

    From 1975 to 2004 a total of 38 children handicapped by congenital multiple arthrogryposis were cared for. The congenital joint contractures demand a major effort in terms of surgical reconstruction. In the case of distal arthrogryposis the chances that patients will be able to walk without help are good, while those with amyoplasia are likely to be dependent on mobility aids throughout their lives. The ultimate goal of treatment for patients is to develop into self-confident adults who can cope with life despite their handicaps. The hip in arthrogryposis shows variable forms of pathology, ranging from the almost normal hip to hip contractures with dislocation. Its treatment has some limited advantages, but hardly improves mobility. The knee contractures are actively treated to allow patients to sit, stand and walk better. The club foot and the rocker-bottom foot need sophisticated conservative and operative treatments. If conservative manipulation of bilateral extension contractures of the elbow fails operative treatment is carried out on the dominant side. For shoulder, hand and finger contractures conservative manipulation brings about little improvement, and surgical approaches help hardly at all. PMID:17323063

  4. Multiple cystic lung disease

    Flavia Angélica Ferreira Francisco

    2015-12-01

    Full Text Available Multiple cystic lung disease represents a diverse group of uncommon disorders that can present a diagnostic challenge due to the increasing number of diseases associated with this presentation. High-resolution computed tomography of the chest helps to define the morphological aspects and distribution of lung cysts, as well as associated findings. The combination of appearance upon imaging and clinical features, together with extrapulmonary manifestations, when present, permits confident and accurate diagnosis of the majority of these diseases without recourse to open-lung biopsy. The main diseases in this group that are discussed in this review are lymphangioleiomyomatosis, pulmonary Langerhans cell histiocytosis and folliculin gene-associated syndrome (Birt–Hogg–Dubé; other rare causes of cystic lung disease, including cystic metastasis of sarcoma, are also discussed. Disease progression is unpredictable, and understanding of the complications of cystic lung disease and their appearance during evolution of the disease are essential for management. Correlation of disease evolution and clinical context with chest imaging findings provides important clues for defining the underlying nature of cystic lung disease, and guides diagnostic evaluation and management.

  5. Multiple cystic lung disease.

    Ferreira Francisco, Flavia Angélica; Soares Souza, Arthur; Zanetti, Gláucia; Marchiori, Edson

    2015-12-01

    Multiple cystic lung disease represents a diverse group of uncommon disorders that can present a diagnostic challenge due to the increasing number of diseases associated with this presentation. High-resolution computed tomography of the chest helps to define the morphological aspects and distribution of lung cysts, as well as associated findings. The combination of appearance upon imaging and clinical features, together with extrapulmonary manifestations, when present, permits confident and accurate diagnosis of the majority of these diseases without recourse to open-lung biopsy. The main diseases in this group that are discussed in this review are lymphangioleiomyomatosis, pulmonary Langerhans cell histiocytosis and folliculin gene-associated syndrome (Birt-Hogg-Dubé); other rare causes of cystic lung disease, including cystic metastasis of sarcoma, are also discussed. Disease progression is unpredictable, and understanding of the complications of cystic lung disease and their appearance during evolution of the disease are essential for management. Correlation of disease evolution and clinical context with chest imaging findings provides important clues for defining the underlying nature of cystic lung disease, and guides diagnostic evaluation and management. PMID:26621970

  6. Bayes Multiple Decision Functions

    Wu, Wensong

    2011-01-01

    This paper deals with the problem of simultaneously making many (M) binary decisions based on one realization of a random data matrix X. M is typically large and X will usually have M rows associated with each of the M decisions to make, but for each row the data may be low dimensional. A Bayesian decision-theoretic approach for this problem is implemented with the overall loss function being a cost-weighted linear combination of Type I and Type II loss functions. The class of loss functions considered allows for the use of the false discovery rate (FDR), false nondiscovery rate (FNR), and missed discovery rate (MDR) in assessing the decision. Through this Bayesian paradigm, the Bayes multiple decision function (BMDF) is derived and an efficient algorithm to obtain the optimal Bayes action is described. In contrast to many works in the literature where the rows of the matrix X are assumed to be stochastically independent, we allow in this paper a dependent data structure with the associations obtained through...

  7. Immunopathogenesis of multiple sclerosis

    Racke Michael

    2009-01-01

    Full Text Available Multiple sclerosis (MS is a suspected autoimmune disease in which myelin-specific CD4+ and CD8+ T cells enter the central nervous system (CNS and initiate an inflammatory response directed against myelin and other components of the CNS. Acute MS exacerbations are believed be the result of active inflammation, and progression of disability is generally believed to reflect accumulation of damage to the CNS, particularly axonal damage. Over the last several years, the pathophysiology of MS is being appreciated to be much more complex, and it appears that the development of the MS plaque involves a large number of cell populations, including CD8+ T lymphocytes, B cells, and Th17 cells (a population of helper T cells that secrete the inflammatory cytokine IL-17. The axonal transection and degeneration that is thought to represent the basis for progressive MS is now recognized to begin early in the disease process and to continue in the progressive forms of the disease. Molecules important for limiting aberrant neural connections in the CNS have been identified, which suppress axonal sprouting and regeneration of transected axons within the CNS. Pathways have also been identified that prevent remyelination of the MS lesion by oligodendrocyte precursors. Novel neuroimaging methodologies and potential biomarkers are being developed to monitor various aspects of the disease process in MS. As we identify the pathways responsible for the clinical phenomena of MS, we will be able to develop new therapeutic strategies for this disabling illness of young adults.

  8. Astrocytes in multiple sclerosis.

    Ludwin, Samuel K; Rao, Vijayaraghava Ts; Moore, Craig S; Antel, Jack P

    2016-08-01

    Recent experimental and clinical studies on astrocytes are unraveling the capabilities of these multi-functional cells in normal homeostasis, and in central nervous system (CNS) disease. This review focuses on understanding their behavior in all aspects of the initiation, evolution, and resolution of the multiple sclerosis (MS) lesion. Astrocytes display remarkable flexibility and variability of their physical structure and biochemical output, each aspect finely tuned to the specific stage and location of the disease, participating in both pathogenic and beneficial changes seen in acute and progressive forms. As examples, chemo-attractive or repulsive molecules may facilitate the entry of destructive immune cells but may also aid in the recruitment of oligodendrocyte precursors, essential for repair. Pro-inflammatory cytokines may attack pathogenic cells and also destroy normal oligodendrocytes, myelin, and axons. Protective trophic factors may also open the blood-brain barrier and modulate the extracellular matrix to favor recruitment and persistence of CNS-specific immune cells. A chronic glial scar may confer structural support following tissue loss and inhibit ingress of further noxious insults and also inhibit migration of reparative cells and molecules into the damaged tissue. Continual study into these processes offers the therapeutic opportunities to enhance the beneficial capabilities of these cells while limiting their destructive effects. PMID:27207458

  9. Humanizing Outgroups Through Multiple Categorization

    Prati, Francesca; Crisp, Richard J.; Meleady, Rose; Rubini, Monica

    2016-01-01

    In three studies, we examined the impact of multiple categorization on intergroup dehumanization. Study 1 showed that perceiving members of a rival university along multiple versus simple categorical dimensions enhanced the tendency to attribute human traits to this group. Study 2 showed that multiple versus simple categorization of immigrants increased the attribution of uniquely human emotions to them. This effect was explained by the sequential mediation of increased individuation of the o...

  10. Creating a Multiple Intelligences Landscape

    Dorminey, Sarah J

    2003-01-01

    The built environment should facilitate a meaningful experience for a user by intellectually engaging their perceptual and cognitive abilities. In 1983, Howard Gardner published his cognitive theory of multiple intelligences. Gardner theorizes that human intelligence is not one single capacity, but is comprised of multiple capacities. Many teachers use the multiple intelligences theory as a tool to reach a larger number of students by engaging their unique learning styles. The theory of mult...

  11. Multiple intelligences in school

    Alejandro Castro Solano

    2016-02-01

    Full Text Available During many years has prevailed the idea of intelligence as a single problem solving ability (factor g considered the best predictor of student’s academic achievement. Recently, researches have begun to take an alternative view of the problem, understanding it is a multidimensional construct. Multiple intelligences (MI theory proposed by Gardner (1983 takes into account seven talents or skills individuals appear to have in certain amount. These latent bio-psychological potentials are stable and they are mantained through life. Theory of MI proposes that every person learns in relation to them. MI theory has many educational applications, however, very few efforts have been made to verify such statements. The main goal of this study is to analyze the IM differential individual profile of high school and university students studying the relation between IM, academic achievement and self efficacy competence on course performance. Two studies were carried out , the first was done with high school students (N=500 and the second with military students (N=362. Based on Armstrong’s proposals to assess IM, an inventory was designed. Main results point out that there is a correspondence between academic attainment, self interest and self perception of competence in different courses students take. MI are good predictors of academic achievement considering specific areas but they don’t provide a better estimation compared to traditional assessment instruments. Students who have failed in school were those with more spatial and corporal abilities, usually relegated by traditional instruction. High achievers were those with more logical and intrapersonal skills. Different relations were found for military students. For these latter students IM theory was not a valuable predictor of successful academic attainment. 

  12. Multiple-image radiography

    Wernick, Miles N.; Wirjadi, Oliver; Chapman, Dean; Zhong, Zhong; Galatsanos, Nikolas P.; Yang, Yongyi; Brankov, Jovan G.; Oltulu, Oral; Anastasio, Mark A.; Muehleman, Carol

    2003-12-01

    Conventional radiography produces a single image of an object by measuring the attenuation of an x-ray beam passing through it. When imaging weakly absorbing tissues, x-ray attenuation may be a suboptimal signature of disease-related information. In this paper we describe a new phase-sensitive imaging method, called multiple-image radiography (MIR), which is an improvement on a prior technique called diffraction-enhanced imaging (DEI). This paper elaborates on our initial presentation of the idea in Wernick et al (2002 Proc. Int. Symp. Biomed. Imaging pp 129-32). MIR simultaneously produces several images from a set of measurements made with a single x-ray beam. Specifically, MIR yields three images depicting separately the effects of refraction, ultra-small-angle scatter and attenuation by the object. All three images have good contrast, in part because they are virtually immune from degradation due to scatter at higher angles. MIR also yields a very comprehensive object description, consisting of the angular intensity spectrum of a transmitted x-ray beam at every image pixel, within a narrow angular range. Our experiments are based on data acquired using a synchrotron light source; however, in preparation for more practical implementations using conventional x-ray sources, we develop and evaluate algorithms designed for Poisson noise, which is characteristic of photon-limited imaging. The results suggest that MIR is capable of operating at low photon count levels, therefore the method shows promise for use with conventional x-ray sources. The results also show that, in addition to producing new types of object descriptions, MIR produces substantially more accurate images than its predecessor, DEI. MIR results are shown in the form of planar images of a phantom and a biological specimen. A preliminary demonstration of the use of MIR for computed tomography is also presented.

  13. [Multiple system atrophy].

    Damon-Perrière, Nathalie; Tison, François; Meissner, Wassilios G

    2010-09-01

    Multiple system atrophy (MSA) is a sporadic neurodegenerative disorder of unknown etiology. It is the most frequent disorder among atypical parkinsonism with an estimated prevalence of 2 to 5 per 100 000 inhabitants. The clinical symptoms are rapidly progressing with a mean survival ranging between 6 to 9 years. The diagnosis is based on consensus criteria that have been revised in 2008. The diagnostic criteria allow defining "possible", "probable" and "definite" MSA. The latter requires post mortem confirmation of striatonigral and olivopontocerebellar degeneration with alpha-synuclein containing glial cytoplasmic inclusions. The diagnosis of "possible" and "probable" MSA is based on the variable presence and severity of parkinsonism, cerebellar dysfunction, autonomic failure and pyramidal signs. According to the revised criteria, atrophy of putamen, pons, middle cerebellar peduncle (MCP) or cerebellum on brain magnetic resonance imaging are considered to be additional features for the diagnosis of "possible" MSA. T2-weighted brain imaging may further reveal a putaminal hypointensity, a hyperintense lateral putaminal rim, the so called "hot cross bun sign" and MCP hyperintensities. Cardiovascular examination, urodynamic testing and anal sphincter electromyography may be helpful for the diagnosis of autonomic failure. Some patients may respond to levodopa, but usually to a lesser extent than those suffering from Parkinson's disease, and high doses are already required in early disease stages. No specific therapy is available for cerebellar dysfunction, while effective treatments exist for urinary and cardiovascular autonomic failure. Physical therapy may help to improve the difficulties of gait and stance, and to prevent their complications. In later disease stages, speech therapy becomes necessary for the treatment of dysarthria and dysphagia. Percutaneous gastrostomy is sometimes necessary in patients with severe dysphagia. Beyond these strategies, psychological

  14. Multiple purpose electrical profit; Emprendimiento electrico de prestacion multiple

    Assennato, H. [Electrica de Azul Ltda., Buenos Aires (Argentina)

    1986-12-31

    This paper shows the multiple purpose aspects of electrification projects in rural and isolated areas. The multiple aspects involved in the electrification process may include, over electric power supply: improvement of life quality, irrigation and rural mechanization. 4 figs., 6 tabs., 4 refs.

  15. Can Multiple Myeloma Be Found Early?

    ... Topic Signs and symptoms of multiple myeloma Can multiple myeloma be found early? It’s difficult to diagnose multiple myeloma early. Often, multiple myeloma causes no symptoms until it reaches an ...

  16. Parameters of Multiple College Attendance.

    Dillon, Paul H.

    This is a report analyzing the multiple community college attendance patterns of students from nine colleges in the Los Angeles Community College District (California) from 1990-2000. The assessment utilizes the Multiple College Index (MCI), which is a measure based on the proportion of units a student earns at different colleges. The study…

  17. Universal features of multiplicity distributions

    Universal features of multiplicity distributions are studied and combinants, certain linear combinations of ratios of probabilities, are introduced. It is argued that they can be a useful tool in analyzing multiplicity distributions of hadrons emitted in high energy collisions and large scale structure of galaxy distributions

  18. Multiple Intelligences for Differentiated Learning

    Williams, R. Bruce

    2007-01-01

    There is an intricate literacy to Gardner's multiple intelligences theory that unlocks key entry points for differentiated learning. Using a well-articulated framework, rich with graphic representations, Williams provides a comprehensive discussion of multiple intelligences. He moves the teacher and students from curiosity, to confidence, to…

  19. Multiple Sclerosis and Vitamin D

    ... Editors David C. Spencer, MD Steven Karceski, MD Multiple sclerosis and vitamin D Andrew J. Solomon, MD WHAT IS VITAMIN ... 133:1869 –1888. 8. Solomon AJ, Whitham RH. Multiple sclerosis and vitamin D: a review and recommendations. Curr Neurol Neurosci ...

  20. The ALICE forward multiplicity detector

    Holm Christensen, Christian; Gulbrandsen, Kristjan; Sogaard, Carsten;

    2007-01-01

    The ALICE Forward Multiplicity Detector (FMD) is a silicon strip detector with 51,200 strips arranged in 5 rings, covering the range $-3.4......The ALICE Forward Multiplicity Detector (FMD) is a silicon strip detector with 51,200 strips arranged in 5 rings, covering the range $-3.4...

  1. Multiple sclerosis: evidence and controversies

    Ángela María Gutiérrez-Álvarez

    2006-01-01

    Introduction: Multiple sclerosis is a chronicrecurrent inflammatory disorder of the centralnervous system. The pharmacological treatmentof multiple sclerosis has been evaluated withmultiple controlled clinical trials that allow theclinician to count with evidence based informationto decide the more indicated treatmentfor each patient.Methodology: A review of the scientific literaturewas conducted to clarify controversialissues in a clinical relevant topic.Development: The diagnostic criteria ...

  2. Centralized Allocation in Multiple Markets

    Monte, Daniel; Tumennasan, Norovsambuu

    | generalizations of Gale's Top Trading Cycles mechanism. We study the centralized allocation that takes place in multiple markets. For example, the assignment of multiple types of indivisible objects; or the assignment of objects in successive periods. We show that the set of strategy-proof, Pareto efficient and...

  3. Multiplicity in Early Stellar Evolution

    Reipurth, Bo; Boss, Alan P; Goodwin, Simon P; Rodriguez, Luis Felipe; Stassun, Keivan G; Tokovinin, Andrei; Zinnecker, Hans

    2014-01-01

    Observations from optical to centimeter wavelengths have demonstrated that multiple systems of two or more bodies is the norm at all stellar evolutionary stages. Multiple systems are widely agreed to result from the collapse and fragmentation of cloud cores, despite the inhibiting influence of magnetic fields. Surveys of Class 0 protostars with mm interferometers have revealed a very high multiplicity frequency of about 2/3, even though there are observational difficulties in resolving close protobinaries, thus supporting the possibility that all stars could be born in multiple systems. Near-infrared adaptive optics observations of Class I protostars show a lower binary frequency relative to the Class 0 phase, a declining trend that continues through the Class II/III stages to the field population. This loss of companions is a natural consequence of dynamical interplay in small multiple systems, leading to ejection of members. We discuss observational consequences of this dynamical evolution, and its influenc...

  4. Epidemiology of multiple sclerosis.

    Leray, E; Moreau, T; Fromont, A; Edan, G

    2016-01-01

    Multiple sclerosis (MS) is the most frequently seen demyelinating disease, with a prevalence that varies considerably, from high levels in North America and Europe (>100/100,000 inhabitants) to low rates in Eastern Asia and sub-Saharan Africa (2/100,000 population). Knowledge of the geographical distribution of the disease and its survival data, and a better understanding of the natural history of the disease, have improved our understanding of the respective roles of endogenous and exogenous causes of MS. Concerning mortality, in a large French cohort of 27,603 patients, there was no difference between MS patients and controls in the first 20 years of the disease, although life expectancy was reduced by 6-7 years in MS patients. In 2004, the prevalence of MS in France was 94.7/100,000 population, according to data from the French National Health Insurance Agency for Salaried Workers (Caisse nationale d'assurance maladie des travailleurs Salariés [CNAM-TS]), which insures 87% of the French population. This prevalence was higher in the North and East of France. In several countries, including France, the gender ratio for MS incidence (women/men) went from 2/1 to 3/1 from the 1950s to the 2000s, but only for the relapsing-remitting form. As for risk factors of MS, the most pertinent environmental factors are infection with Epstein-Barr virus (EBV), especially if it arises after childhood and is symptomatic. The role of smoking in MS risk has been confirmed, but is modest. In contrast, vaccines, stress, traumatic events and allergies have not been identified as risk factors, while the involvement of vitamin D has yet to be confirmed. From a genetic point of view, the association between HLA-DRB1*15:01 and a high risk of MS has been known for decades. More recently, immunogenetic markers have been identified (IL2RA, IL7RA) and, in particular thanks to studies of genome-wide associations, more than 100 genetic variants have been reported. Most of these are involved in

  5. Constructing Dynamic Multiple-Input Multiple-Output Logic Gates

    Jinghua Xiao; Yixian Yang; Lixiang Li; Gang Hu; Haipeng Peng

    2011-01-01

    Investigation of computing devices with dynamic architecture which makes devices have reconfigurable ability is an interesting research direction for designing the next generation of computer chip. In this paper, we present a window threshold method to construct such dynamic logic architecture. Here, dynamic multiple-input multiple-output (MIMO) logic gates are proposed, analyzed, and implemented. By using a curve-intersections-based graphic method, we illustrate the relationships among the t...

  6. On Multiple-Layered Vortices

    Rossow, Vernon J.

    2011-01-01

    As part of an ongoing effort to find ways to make vortex flow fields decompose more quickly, photographs and observations are presented of vortex flow fields that indicate the presence of multiple layers of fluid rotating about a common axis. A survey of the literature indicates that multiple-layered vortices form in waterspouts, tornadoes and lift-generated vortices of aircraft. An explanation for the appearance of multiple-layered structures in vortices is suggested. The observations and data presented are intended to improve the understanding of the formation and persistence of vortex flow fields.

  7. Business applications of multiple regression

    Richardson, Ronny

    2015-01-01

    This second edition of Business Applications of Multiple Regression describes the use of the statistical procedure called multiple regression in business situations, including forecasting and understanding the relationships between variables. The book assumes a basic understanding of statistics but reviews correlation analysis and simple regression to prepare the reader to understand and use multiple regression. The techniques described in the book are illustrated using both Microsoft Excel and a professional statistical program. Along the way, several real-world data sets are analyzed in deta

  8. Phenomenology of high multiplicity events

    Kokoulina, E. S.; SVD Collaboration

    2015-05-01

    Study of high multiplicity events in proton-proton (nucleus) interactions is carried out at U-70 accelerator of IHEP, Protvino. These events are extremely rare. Usually, MC codes underestimate topological cross sections in this region. Gluon dominance model has been offered to describe them. Some collective phenomena can be observed in high multiplicity events. SVD-2 Collaboration has obtained the evidence of pion condensate formation at high total multiplicity. Our future program is aimed at studying soft photon yield puzzle at U-70 and Nuclotronfacility at JINR, Dubna.

  9. Multiplicative updates for the LASSO

    Mørup, Morten; Clemmensen, Line Katrine Harder

    Multiplicative updates have proven useful for non-negativity constrained optimization. Presently, we demonstrate how multiplicative updates also can be used for unconstrained optimization. This is for instance useful when estimating the least absolute shrinkage and selection operator (LASSO), i.......e. least squares minimization with $L_1$-norm regularization, since the multiplicative updates (MU) can efficiently exploit the structure of the problem traditionally solved using quadratic programming (QP). We derive an algorithm based on MU for the LASSO and compare the performance to Matlabs standard QP...

  10. Multiplicities in high energy interactions

    This paper reviews the data on multiplicities in high energy interactions. Results from e+e- annihilation, from neutrino interactions, and from hadronic collisions, both diffractive and nondiffractive, are compared and contrasted. The energy dependence of the mean charged multiplicity, , as well as the rapidity density at Y = 0 are presented. For hadronic collisions, the data on neutral pion production shows a strong correlation with . The heavy particle fractions increase with √s up to the highest energies. The charged particle multiplicity distributions for each type of reaction show a scaling behavior when expressed in terms of the mean. Attempts to understand this behavior, which was first predicted by Koba, Nielsen, and Olesen, are discussed. The multiplicity correlations and the energy variation of the shape of the KNO scaling distribution provide important constraints on models. Some extrapolations to the energies of the Superconducting Super Collider are made. 51 refs., 27 figs

  11. Humanizing Outgroups Through Multiple Categorization

    Prati, Francesca; Crisp, Richard J.; Meleady, Rose; Rubini, Monica

    2016-01-01

    In three studies, we examined the impact of multiple categorization on intergroup dehumanization. Study 1 showed that perceiving members of a rival university along multiple versus simple categorical dimensions enhanced the tendency to attribute human traits to this group. Study 2 showed that multiple versus simple categorization of immigrants increased the attribution of uniquely human emotions to them. This effect was explained by the sequential mediation of increased individuation of the outgroup and reduced outgroup threat. Study 3 replicated this sequential mediation model and introduced a novel way of measuring humanization in which participants generated attributes corresponding to the outgroup in a free response format. Participants generated more uniquely human traits in the multiple versus simple categorization conditions. We discuss the theoretical implications of these findings and consider their role in informing and improving efforts to ameliorate contemporary forms of intergroup discrimination. PMID:26984016

  12. Multiple isolated cutaneous plexiform schwannomas

    Enas A. S. Attia

    2011-01-01

    Full Text Available Plexiform schwannoma is a rare neurogenic tumor, arising from skin and subcutaneous tissue. The presence of multiple schwannomas suggests a possible association with neurofibromatosis type 2 (NF2. A 50-year old male patient presented with multiple papulo-nodular cutaneous lesions on both arms and forearms. Histopathological examination revealed a dermal multinodular pattern of well-circumscribed masses of closely packed cells, with peripheral myxoid tissue, well-encapsulated in a thin collagenous capsule. S-100 immunohistochemical staining was diffusely and strongly positive. Neuron-specific enolase was positive, confirming a neural tissue tumor. An audiogram and Magnetic Resonance Imaging (MRI of cerebro-pontine angle showed no detected abnormality, excluding acoustic neuroma. Thus, we present a case of multiple bilateral isolated cutaneous plexiform schwannomas, not associated with NF2. Multiple plexiform schwannomas is a very rare entity, distinct from neurofibromatosis (NF, and being confined to the dermis is even more rarely reported.

  13. MULTIPLE SCALES FOR SUSTAINABLE RESULTS

    This session will highlight recent research that incorporates the use of multiple scales and innovative environmental accounting to better inform decisions that affect sustainability, resilience, and vulnerability at all scales. Effective decision-making involves assessment at mu...

  14. Multiple sclerosis after infectious mononucleosis

    Nielsen, Trine Rasmussen; Rostgaard, Klaus; Nielsen, Nete Munk; Koch-Henriksen, Nils; Haahr, Sven; Sørensen, Per Soelberg; Hjalgrim, Henrik

    2007-01-01

    BACKGROUND: Infectious mononucleosis caused by the Epstein-Barr virus has been associated with increased risk of multiple sclerosis. However, little is known about the characteristics of this association. OBJECTIVE: To assess the significance of sex, age at and time since infectious mononucleosis......, and attained age to the risk of developing multiple sclerosis after infectious mononucleosis. DESIGN: Cohort study using persons tested serologically for infectious mononucleosis at Statens Serum Institut, the Danish Civil Registration System, the Danish National Hospital Discharge Register, and the...... Danish Multiple Sclerosis Registry. SETTING: Statens Serum Institut. PATIENTS: A cohort of 25 234 Danish patients with mononucleosis was followed up for the occurrence of multiple sclerosis beginning on April 1, 1968, or January 1 of the year after the diagnosis of mononucleosis or after a negative Paul...

  15. Sequential and simultaneous multiple explanation

    Robert Litchfield

    2007-02-01

    Full Text Available This paper reports two experiments comparing variants of multiple explanation applied in the early stages of a judgment task (a case involving employee theft where participants are not given a menu of response options. Because prior research has focused on situations where response options are provided to judges, we identify relevant dependent variables that an intervention might affect when such options are not given. We use these variables to build a causal model of intervention that illustrates both the intended effects of multiple explanation and some potentially competing processes that it may trigger. Although multiple explanation clearly conveys some benefits (e.g., willingness to delay action to engage in information search, increased detail, quality and confidence in alternative explanations in the present experiments, we also found evidence that it may initiate or enhance processes that attenuate its advantages (e.g., feelings that one does not need more data if one has multiple good explanations.

  16. Multiple myeloma. Houses and spouses

    Two families in which successive spouses who lived in the same house developed multiple myeloma are reported. In the first instance, a man whose first wife died of multiple myeloma remarried, and his second wife also developed myeloma. In the second family, a woman's first husband died of multiple myeloma and her second husband did too. Radiation studies of the houses and yards showed no increased radioactivity. No evidence was found for excessive exposure to chemicals or other environmental agents, for contact with other patients having similar malignancies, or for exposure to viruses or other transmissible factors. The significance of the occurrence of multiple myeloma in subsequent spouses is unknown. It is hoped that this report will stimulate research for other instances and lead to careful epidemiologic, radiologic, and virologic studies

  17. The ALICE forward multiplicity detector

    The ALICE experiment is designed to study the properties of hadron and nucleus collisions in a new energy regime at the Large Hadron Collider at CERN. A fundamental observable in such collisions is the multiplicity distribution of charged particles. A forward multiplicity detector has been designed to extend the charged particle multiplicity coverage of the ALICE experiment to pseudorapidities of -3.4<η<-1.7 and 1.7<η<5.0. This detector consists of five rings, each containing 10240 Si strips, divided into sectors comprised of Si sensors bonded and glued to hybrid PC boards equipped with radiation hard preamplifiers. The output of these preamplifiers is multiplexed into custom-made fast ADC chips located directly behind the Si sensors on the detector frame. These ADCs are read out, via optical fibers, to a data acquisition farm of commodity PCs. The design and characteristics of the ALICE Forward Multiplicity Detector will be discussed

  18. Current concepts in multiple sclerosis

    This volume contains 9 articles dealing with the use of nuclear magnetic resonance imaging and positron emitted tomography in the diagnosis and staging of multiple sclerosis. (H.W.). refs.; figs.; tabs

  19. Multiple sclerosis and organic solvents

    Mortensen, J T; Brønnum-Hansen, Henrik; Rasmussen, K

    1998-01-01

    We investigated a possible causal relation between exposure to organic solvents in Danish workers (housepainters, typographers/printers, carpenters/cabinetmakers) and onset of multiple sclerosis. Data on men included in the Danish Multiple Sclerosis Register (3,241 men) were linked with data from...... butchers. Over a follow-up period of 20 years, we observed no increase in the incidence of multiple sclerosis among men presumed to be exposed to organic solvents. It was not possible to obtain data on potential confounders, and the study design has some potential for selection bias. Nevertheless, the...... study does not support existing hypotheses regarding an association between occupational exposure to organic solvents and multiple sclerosis....

  20. Unconstrained multiple-people tracking

    Rowe, Daniel; Reid, Ian; Gonzàlez, Jordi; Villanueva, Juan J.

    2006-01-01

    This work presents two main contributions to achieve robust multiple-target tracking in uncontrolled scenarios. A novel system which consists on a hierarchical architecture is proposed. Each level is devoted to one of the main tracking functionalities: target detection, low-level tracking, and high-level tasks such as target-appearance representation, or event management. Secondly, tracking performances are enhanced by on-line building and updating multiple appearance models. Successful exper...

  1. Revisiting Overflow in Integer Multiplication

    Eyas El-Qawasmeh; Ahmed Dalalah

    2005-01-01

    Integer multiplication is a very common operation that is executed in many applications. However, some of these applications suffer from the overflow problem caused by the multiply operation of two operands. The overflow occurs whenever the multiplication of any two-integer numbers exceeds the maximum limit available for the result. Many programming languages ignored this problem; therefore, the programmer has to handle it, mostly in predict and avoid approach. Presen...

  2. Budget Online Multiple Kernel Learning

    Lu, Jing; Steven C. H. Hoi; Sahoo, Doyen; Zhao, Peilin

    2015-01-01

    Online learning with multiple kernels has gained increasing interests in recent years and found many applications. For classification tasks, Online Multiple Kernel Classification (OMKC), which learns a kernel based classifier by seeking the optimal linear combination of a pool of single kernel classifiers in an online fashion, achieves superior accuracy and enjoys great flexibility compared with traditional single-kernel classifiers. Despite being studied extensively, existing OMKC algorithms...

  3. Multiplicities and correlations at LEP

    Sarkisyan-Grinbaum, E

    2002-01-01

    A brief review on recent charge multiplicity and correlation measurements at LEP is given. The measurements of unbiased gluon jet multiplicity are discussed. Recent results on charged particle Bose- Einstein and Fermi-Dirac correlations at LEP1. are reported. New results on two-particle correlations of neutral pions are given. Correlations of more than two particles (high-order correlations) obtained using different methods are performed. Recent Bose-Einstein correlation measurements at LEP2 are discussed. (13 refs).

  4. Techniques for multiple database integration

    Whitaker, Barron D

    1997-01-01

    Approved for public release; distribution is unlimited There are several graphic client/server application development tools which can be used to easily develop powerful relational database applications. However, they do not provide a direct means of performing queries which require relational joins across multiple database boundaries. This thesis studies ways to access multiple databases. Specifically, it examines how a 'cross-database join' can be performed. A case study of techniques us...

  5. Multiple Steady States in Distillation

    Bekiaris, Nikolaos

    1995-01-01

    We study multiple steady states in distillation. We first analyze the simplest case of ternary homogeneous azeotropic mixtures. We show that in the case of infinite reflux and an infinite number of trays (∞/∞ case) one can construct bifurcation diagrams on physical grounds with the distillate flow as the bifurcation parameter. Multiple steady states exist when the distillate flow varies non-monotonically along the continuation path of the bifurcation diagram. We derive a necessary and suffici...

  6. Multiple directorships in unlisted SMEs

    Voordeckers, Wim; STEIJVERS, Tensie; Roger MERCKEN

    2009-01-01

    During the last decade, several studies examined the benefits and detriments of multiple directorships in listed firms. Recently, more formal governance guidelines for SMEs emerged and strongly recommended the adoption of outside directors, making the discussion about multiple directorships in unlisted SMEs relevant as well. Results reveal that a busy board positively influences performance except for high growth ventures in which a busy board seems to be detrimental to performance. Results a...

  7. Multiple sclerosis - New treatment modalities

    Rocco Totaro; Caterina Di Carmine; Carmine Marini; Antonio Carolei

    2015-01-01

    Ever since the introduction of the first disease modifying therapies, the concept of multiple sclerosis treatment algorithms developed ceaselessly. The increasing number of available drugs is paralleled by impelling issue of ensuring the most appropriate treatment to the right patient at the right time. The purpose of this review is to describe novel agents recently approved for multiple sclerosis treatment, namely teriflunomide, alemtuzumab and dimethylfumarate, focusing on mechanism of acti...

  8. Multiplicative weights in monotropic games

    Avramopoulos, Ioannis

    2014-01-01

    We introduce a new class of population games that we call monotropic; these are games characterized by the presence of a unique globally neutrally stable Nash equilibrium. Monotropic games generalize strictly concave potential games and zero sum games with a unique minimax solution. Within the class of monotropic games, we study a multiplicative weights dynamic. We show that, depending on a parameter called the learning rate, multiplicative weights are interior globally convergent to the uniq...

  9. Semi-Supervised Multiple Disambiguation

    Ghoorchian, Kambiz; Rahimian, Fatemeh; Girdzijauskas, Sarunas

    2015-01-01

    Determining the true entity behind an ambiguousword is an NP-Hard problem known as Disambiguation. Previoussolutions often disambiguate a single ambiguous mention acrossmultiple documents. They assume each document contains onlya single ambiguous word and a rich set of unambiguous contextwords. However, nowadays we require fast disambiguation ofshort texts (like news feeds, reviews or Tweets) with few contextwords and multiple ambiguous words. In this research we focuson Multiple Disambiguati...

  10. Multiple Imputation Using SAS Software

    Yang Yuan

    2011-01-01

    Multiple imputation provides a useful strategy for dealing with data sets that have missing values. Instead of filling in a single value for each missing value, a multiple imputation procedure replaces each missing value with a set of plausible values that represent theuncertainty about the right value to impute. These multiply imputed data sets are then analyzed by using standard procedures for complete data and combining the results from these analyses. No matter which complete-data analysi...

  11. Constraining multiple systems with GAIA

    Beauvalet, L.; Lainey, V.; Arlot, J.-E.; Bancelin, D.; Marchis, F.; Binzel, Richard P.

    2012-01-01

    GAIA will provide observations of some multiple asteroid and dwarf systems. These observations are a way to determine and improve the quantification of dynamical parameters, such as the masses and the gravity fields, in these multiple systems. Here we investigate this problem in the cases of Pluto's and Eugenia's system. We simulate observations reproducing an approximate planning of the GAIA observations for both systems, as well as the New Horizons observations of Pluto. We have developed a...

  12. Nuclear modification of jet multiplicities

    Dremin, I M

    2005-01-01

    Equations for the QCD generating functions of multiplicity distributions are modified to account for nuclear effects. It is shown that the mean multiplicities in quark and gluon jets produced in nucleus-nucleus collisions are sensitive to these modifications. Their increase with energy becomes power-like. Combined with rapidity spectra, they can be used as a QGP thermometer. The effective coupling strength is related to softening of particles spectra and to the temperature regimes during the collision.

  13. Mechanisms of multiple production processes

    Theoretical approaches to multiple production processes are discussed. A large number of models proceeds from the notion about common excited system produced by colliding hadrons. This class of models includes the hydrodynamical, statistical, thermodynamical and statistical bootstrap models. Sometimes the production process is due to excitation and decay of two colliding particles. The fragmentation bremsstrahlung and inelastic diffraction models belong to this group. The largest group of models describes the multiple production process as a result of formation of many excited centers. The typical example is the multiperipheral model. An interesting direction is given by the attempts to interrelate the mechanism of multiple production with internal structure of particles that is with their constituents (C-group)'-quarks, gluons, etc. Besides the models there are phenomenological (p group) attempts to connect different features of multiple production. Experimental data indicate the existence of leading and pionization particles thus giving an evidence for applications of different models. The data about increase of total and inclusive cross sections, the behaviour of the mean multiplicity and correlations at high energies provide a clue for further development of multiple production theory

  14. Multiple hashes of single key with passcode for multiple accounts

    2007-01-01

    A human's e-life needs multiple offline and online accounts. It is a balance between usability and security to set keys or passwords for these multiple accounts. Password reuse has to be avoided due to the domino effect of malicious administrators and crackers. However, human memorability constrains the number of keys. Single sign-on server, key hashing, key strengthening and petname system are used in the prior arts to use only one key for multiple online accounts. The unique site keys are derived from the common master secret and specific domain name. These methods cannot be applied to offline accounts such as file encryption. We invent a new method and system applicable to offline and online accounts. It does not depend on HTTP server and domain name, but numeric 4-digit passcode, key hashing, key strengthening and hash truncation. Domain name is only needed to resist spoofing and phishing attacks of online accounts.

  15. TOPOLOGY OPTIMIZATION OF MULTIPLE INPUTS AND MULTIPLE OUTPUTS COMPLIANT MECHANISMS

    ZHANG Xianmin; OUYANG Gaofei; WANG Hua

    2007-01-01

    An optimal topology design method for multiple inputs and multiple outputs compliant micro-manipulation system is presented. Firstly, the topology design problem is posed in terms of a multiple inputs load and several specified output deflections. The compliance and stiffness of the system are expressed by the mutual potential energy and strain energy, respectively, which can be controlled by a multi-criteria objective function. Secondly, based on the optimality criteria method, a model solution algorithm is presented. Finally, a numerical example is presented to show the validity of the presented technique. The optimal topology of a 4 inputs and 4 outputs compliant mechanism is obtained by using the method, and the corresponding micro-positioning stage system is further designed.

  16. Congenital malformations in multiple births

    Sharada B. Menasinkai

    2013-06-01

    Full Text Available Objective: The present study was done to know and compare the incidence of congenital malformations in singleton and multiple births in our hospital & compare with other studies. Methods: A retrospective study done by collecting the data from parturition register from Jan 2008 to Dec 2011 (4yrs from Cheluvamba Hospital attached to Mysore Medical College and Research Institute. Total number of the live births, still births, and abortions> 20 wks were collected. Details of multiple births such as maternal age, gestational age, sex & birth weight of the babies, U/S reports and congenital anomalies (CA were noted. Results: The total number of singleton births were 48700 and number of babies who had congenital malformations were 235 (48.25/10,000 births.Total number of multiple births were 579 including 10 triplets and number of babies who had CA were 11 (189.98/10,000 births, P<0.0001. In the present study sex of the babies were noted in all multiple births and zygosity could not be recorded. Among 579 multiple births 404 were of the Same Sex (SS and 165 were of Opposite Sex (OS in twins and 6 were of the same sex and 4 were of opposite sex in triplets. According to Weinberg formula 50% of same sex (SS twins are monozygotic and 50% are dizygotic twins. Among the 11 babies with CA, 4 monozygotic twins had anomalies related to twinning such as Acardia with TRAP sequence (3 twins, and Thoracophagus (1 twin.5 babies had CNS anomalies, 1 with cystic hygroma, 1 baby with multiple system affected. Conclusion: The incidence of birth defects is more in multiple births and especially in monozygotic twins. In the present days increase in twinning rate due to advanced maternal age, hereditary factors and use of ovulation inducing drugs, which results in premature and low birth wt babies associated with poor lung maturity. [Int J Res Med Sci 2013; 1(3.000: 216-221

  17. Gasdynamic Multiple-Mirror Trap

    Beklemishev, Alexei; Anikeev, Andrei; Bagryansky, Peter; Burdakov, Alexander; Gavrilenko, Dmitrii; Ivanov, Alexander; Polosatkin, Sergei; Sinitsky, Stanislav

    2013-10-01

    The new linear device for confinement of fusion plasmas, GDMT, is being developed at the Budker Institute of Nuclear Physics, Novosibirsk. The facility will combine features of existing GOL-3 and GDT devices: the central GDT-like cell with sloshing NBI ions, and the multiple-mirror plugs for suppression of axial losses. Such combination became feasible due to recent discoveries. In particular, the requirement of flute-mode stability can be relaxed by using vortex confinement, achieved by plasma biasing through open field lines. This allows the use of potentially destabilizing multiple-mirror sections. Another key effect is the enhanced multiple-mirror confinement at low densities, which is due to collective rather than coulomb scattering of ions. Hence the multiple-mirror plugs can work at pressures compatible with magnetic confinement. These two main technologies are supplemented by axial injection of pulsed electron beams. Besides additional plasma heating (like in GOL-3), such injection can be used for induced collective scattering in the multiple-mirror plugs and for plasma biasing. The new device is designed to be superconducting and modular. It will be built in stages, with the first stage, GDMT-T, intended for PMI studies. The work was financially supported by Ministry of Education and Science RF.

  18. Revisiting Overflow in Integer Multiplication

    Eyas El-Qawasmeh

    2005-01-01

    Full Text Available Integer multiplication is a very common operation that is executed in many applications. However, some of these applications suffer from the overflow problem caused by the multiply operation of two operands. The overflow occurs whenever the multiplication of any two-integer numbers exceeds the maximum limit available for the result. Many programming languages ignored this problem; therefore, the programmer has to handle it, mostly in “predict and avoid” approach. Present study addresses the detection and control of integer overflow in programming languages. Two examples from C and JAVA programming languages are considered. The paper suggests “detect and do” algorithms to handle the overflow. In addition, this paper suggests adding a built-in function to test whether an overflow will be generated by multiplication operation in advance.

  19. Multiple sclerosis and herpesvirus interaction

    Guilherme Sciascia do Olival

    2013-09-01

    Full Text Available Multiple sclerosis is the most common autoimmune inflammatory demyelinating disease of the central nervous system, and its etiology is believed to have both genetic and environmental components. Several viruses have already been implicated as triggers and there are several studies that implicate members of the Herpesviridae family in the pathogenesis of MS. The most important characteristic of these viruses is that they have periods of latency and exacerbations within their biological sanctuary, the central nervous system. The Epstein-Barr, cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 viruses are the members that are most studied as being possible triggers of multiple sclerosis. According to evidence in the literature, the herpesvirus family is strongly involved in the pathogenesis of this disease, but it is unlikely that they are the only component responsible for its development. There are probably multiple triggers and more studies are necessary to investigate and define these interactions.

  20. Palliative radiotherapy for multiple myeloma

    This study reviews the experience of palliative radiotherapy to patients with multiple myeloma to define the optimal dose for pain relief. The records of 31 patients (66 sites) with multiple myeloma irradiated for palliation at Kumamoto University hospital between 1985 and 1994 were reviewed. Total dose ranged from 8 to 50 Gy, with a mean of 32.2 Gy. Symptoms included pain (78.1%), neurological abnormalities (28.1%), and palpable masses (34.3%). Symptomatic remission was obtained in 45 of 46 evaluable sites (97.8%). Complete remission of symptoms were obtained in 28.3%, and partial remission in 69.6%. According to fraction size, there was no significant difference between 3-5 Gy and 1.8-2 Gy. The incidence of complete remission increased when a total dose of more than 20 Gy was given. When the quality of life is considered, hypofractionation was recommended for the palliative radiation therapy of multiple myeloma. (author)

  1. Multiple myeloma: evaluation by CT

    Although patients who have multiple myeloma usually have straightforward clinical symptoms and corroborative radiographs, in some instances, these patients will present atypically, with symptoms suggesting active disease but radiographs that are normal or nonspecific. The authors reviewed the records of 32 patients who had documented multiple myeloma and had undergone CT examinations, assessing the value of those examinations. Although CT is not indicated in all patients who have multiple myeloma, it is especially useful in patients who have bone pain and normal or nonspecific radiographs. CT provided confirmatory information in all cases in which lesions were seen on radiographs. CT also frequently demonstrated a greater extent of disease than could be appreciated on the radiographs

  2. Patients with multiple contact allergies

    Carlsen, Berit Christina; Andersen, Klaus Ejner; Menné, Torkil;

    2008-01-01

    limited. This review presents the current knowledge on the topic and discusses the evidence and characteristics of an increased susceptibility factor, possible causes to and genetic markers for the increased susceptibility, composition of the patient group and identification of patients at risk of...... developing multiple contact allergies. Evidence of allergen clusters among polysensitized individuals is also reviewed. The literature supports the idea that patients with multiple contact allergies constitute a special entity within the field of contact allergy. There is no generally accepted definition of...

  3. Goiter and Multiple Food Allergies

    Stefanie Leniszewski

    2009-01-01

    Full Text Available Severe iodine deficiency results in impaired thyroid hormone synthesis and thyroid enlargement. In the United States, adequate iodine intake is a concern for women of childbearing age and pregnant women. Beyond this high risk group iodine deficiency is not considered to be a significant problem. This case report describes a 12-year-old male with severe iodine deficiency disorder (IDD resulting from restricted dietary intake due to multiple food allergies. We describe iodine replacement for this patient and continued monitoring for iodine sufficiency. Children with multiple food allergies, in particular those with restrictions to iodized salt and seafood, should be considered high risk for severe iodine deficiency.

  4. MULTIPLE MELTING IN NYLON 1010

    FU Shuren; CHEN Taoyung

    1983-01-01

    Multiple melting behavior of nylon 1010 has been investigated by using DSC instrument. Effects of partial scanning, partial scanning and annealing, heating rate, cooling rate and stepwise annealing on the melting curve were studied. Experimental results indicate that the sample undergoes a process of continuous melting and recrystallization during DSC scanning. Nylon 1010 contains a distribution of crystallites of different degrees of perfection which is strongly dependent on its previous thermal history. From the structural reorganization point of view, the origin of double and multiple peaks of the melting curve is explained.

  5. Goiter and Multiple Food Allergies

    Leniszewski Stefanie

    2009-03-01

    Full Text Available Severe iodine deficiency results in impaired thyroid hormone synthesis and thyroid enlargement. In the United States, adequate iodine intake is a concern for women of childbearing age and pregnant women. Beyond this high risk group iodine deficiency is not considered to be a significant problem. This case report describes a 12-year-old male with severe iodine deficiency disorder (IDD resulting from restricted dietary intake due to multiple food allergies. We describe iodine replacement for this patient and continued monitoring for iodine sufficiency. Children with multiple food allergies, in particular those with restrictions to iodized salt and seafood, should be considered high risk for severe iodine deficiency.

  6. Multiple trichoepitheliomas: A rare occurrence

    Arvind Karikal

    2013-01-01

    Full Text Available Trichoepitelioma is an extremely rare cosmetically disfiguring condition usually affecting the females. Trichoepitheliomas are benign lesions seen on the face, which are thought to derive from the hair follicle. Malignant transformation to basal cell carcinoma is rare and occurs late in the course of the disease These lesions are often misinterpreted and diagnosed clinically as neurofibromatosis or histpathologically as basal cell carcinoma. We report a case of multiple trichoepithelioma occurring in a male patient. The patient presented with multiple dermatologic growths on the face with varied histopathological presentations which have been described in detail.

  7. Cognitive deficits in multiple sclerosis

    Lund, H; Jønsson, A; Andresen, Jesper Graubæk;

    2012-01-01

    Objectives - Although disease load in multiple sclerosis (MS) often is based on T2 lesion volumes, the changes in T2 of normal appearing brain tissue (NABT) are rarely considered. By means of magnetic resonance, (MR) we retrospectively investigated whether T2 changes in NABT explain part of the...... Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Impairment Scale (MSIS). Voxel-wise T2 estimates and total T2 lesion volume were tested for correlations with eight cognitive domains, a general cognitive dysfunction factor (CDF), and the two clinical scales. Results - We found distinct...

  8. Multiplicity description by gluon model

    Kokoulina, E S

    2015-01-01

    Study of high multiplicity events in proton-proton interactions is carried out at the U-70 accelerator (IHEP, Protvino). These events are extremely rare. Usually, Monte Carlo codes underestimate topological cross sections in this region. The gluon dominance model (GDM) was offered to describe them. It is based on QCD and a phenomenological scheme of a hadronization stage. This model indicates a recombination mechanism of hadronization and a gluon fission. Future program of the SVD Collaboration is aimed at studying a long-standing puzzle of excess soft photon yield and its connection with high multiplicity at the U-70 and Nuclotron facility at JINR, Dubna.

  9. An Efficient Multiple Predicate Learner

    张晓龙; MasayukiNumao

    1998-01-01

    In this paper,we examine the issue of learning multiple predicates from given training examples.A proposed MPL-CORE algorithm efficiently induces Horm clauses from examples and background knowledge by employing a single predicate learning module CORE.A fast failure mechanism is also proposed which contributes learning efficiency and learnability to the algorithm.MPL-CORE employs background knowledge that can be represented in intensional(Horn clauses)or extensional (ground atoms)orms during its learning process.With the fast failure mechanism,MPL-CORE outperforms precious multiple predicate learning systems in both the computational complexity and learnability.

  10. Polarimetry with multiple mirror telescopes

    West, S. C.

    1986-01-01

    The polarizations of multiple mirror telescopes are calculated using Mueller calculus. It is found that the Multiple Mirror Telescope (MMT) produces a constant depolarization that is a function of wavelength and independent of sky position. The efficiency and crosstalk are modeled and experimentally verified. The two- and four-mirror new generation telescopes are found to produce sinusoidal depolarization for which an accurate interpretation of the incident Stokes vector requires inverse matrix calculations. Finally, the depolarization of f/1 paraboloids is calculated and found to be less than 0.1 percent at 3000 A.

  11. Systematic imaging review: Multiple Sclerosis

    Aparna Katdare

    2015-01-01

    Full Text Available Multiple sclerosis (MS is a chronic, inflammatory disease of the central nervous system characterised by immune-mediated demyelination, and is a leading cause of neurological disability worldwide. It has a wide spectrum of clinical presentations which overlap with other neurological conditions many times. Further, the radiological array of findings in MS can also be confused for multiple other conditions, leading to the need to look for the more typical findings, and interpret these in close conjunction with the clinical picture including temporal evolution. This review aims to revisit the MRI findings in MS, including recent innovations in imaging, and to help distinguish MS from its mimics.

  12. Advances in multiple analyte profiling.

    Salas, Virginia M; Edwards, Bruce S; Sklar, Larry A

    2008-01-01

    The advent of multiparameter technology has been driven by the need to understand the complexity in biological systems. It has spawned two main branches, one in the arena of high-content measurements, primarily in microscopy and flow cytometry where it has become commonplace to analyze multiple fluorescence signatures arising from multiple excitation sources and multiple emission wavelengths. Microscopy is augmented by topographical content that identifies the source location of the signature. The other branch involves multiplex technology. Here, the intent is to measure multiple analytes simultaneously. A key feature of multiplexing is an address system for the individual analytes. In planar arrays the address system is spatial, in which affinity reactions occur at defined locations. In suspension arrays, the address is encoded as a fluorescent signature in the particle assigned to a specific reaction or analyte. Several hybrid systems have also been developed for multiplexing. In the commercial regime, the most widespread applications of multiplexing are currently in the areas of genome and biomarker analysis. Planar chips with fixed arrays are now available to probe the entire genome at the level of message expression and large segments of the genome at the level of single nucleotide polymorphism (SNP). In contrast, suspension arrays provide the potential for probing segments of the genome in a customized way, using capture tags that locate specific oligonucleotide sequences to specific array elements. PMID:18429493

  13. Multiple fractures in early infancy

    Two cases of multiple fractures, one in a newborn with an unclassified bone dysplasia, another in an infant with recurrent fits of unknown etiology are reported. The second case is the youngest in the literature with bilateral slipped capital femoral epiphyses and bilateral femoral neck fractures, secondary to stress injury. (orig.)

  14. Permutation tests for multiple changes

    Hušková, Marie; Slabý, A.

    2001-01-01

    Roč. 37, č. 5 (2001), s. 605-622. ISSN 0023-5954 R&D Projects: GA ČR GA201/00/0769 Institutional research plan: AV0Z1075907 Keywords : location models * multiple changes * testing Subject RIV: BA - General Mathematics Impact factor: 0.316, year: 2001

  15. Psychiatric onset of multiple sclerosis.

    Jongen, P.J.H.

    2006-01-01

    We present a patient with psychotic disorder as onset of relapsing-remitting multiple sclerosis (MS). In this patient, a 26-year-old female, neurological examination revealed only minor abnormalities. As cranial CT scan was normal, her psychosis was diagnosed as psychogenic. Literature on psychiatri

  16. Occupational therapy for multiple sclerosis.

    Steultjens, E.M.J.; Dekker, J.; Bouter, L.M.; Cardol, M.; Nes, J.C.M. van de; Ende, C.H.M. van den

    2003-01-01

    Background: Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration of upper extremity fine motor coordination, loss of sensation and spasticity that causes limitations in performance of activities of daily living and social part

  17. Moliere's multiple scattering theory revisited

    Voskresenskaya, O.; Tarasov, A.

    2012-01-01

    A part of Moliere's multiple scattering theory concerning the determination of the screening angular parameter is revised. An universal form of the Coulomb corrections to the screening angle, the exponential part of the distribution function, and the angular distribution is discussed within the small-angle approximation of this theory. The accuracy of the Moliere theory in determining the screening angle is estimated.

  18. Fashion, Paper Dolls and Multiplicatives

    Ura, Suzana Kaori; Stein-Barana, Alzira C. M.; Munhoz, Deisy P.

    2011-01-01

    The multiplicative principle is the tool allowing the counting of groups that can be described by a sequence of events. An event is a subset of sample space, i.e. a collection of possible outcomes, which may be equal to or smaller than the sample space as a whole. It is important that students understand this basic principle early on and know how…

  19. The immunogenetics of multiple sclerosis

    Svejgaard, A.

    2008-01-01

    complex genetic backgrounds. HLA controls immune response genes and HLA associations indicate the involvement of autoimmunity. Multiple sclerosis (MS) was one of the first conditions proven to be HLA associated involving primarily HLA class II factors. We review how HLA studies give fundamental...

  20. [Biological treatment of multiple sclerosis

    Sorensen, P.S.; Sellebjerg, F.

    2008-01-01

    In 1996 interferon (IFN)beta was the first biopharmaceutical product to be approved for the treatment of relapsing-remitting multiple sclerosis (MS). In 2006 the more potent monoclonal antibody natalizumab was approved. Presently, a number of monoclonal antibodies are being studied, including...

  1. Multiple Ligament Knee Injury: Complications

    Manske, Robert C.; Hosseinzadeh, Pooya; Giangarra, Charles E.

    2008-01-01

    Non-operative and operative complications are common following multiple ligament knee injuries. This article will describe common complications seen by the surgeon and physical therapist following this complex injury. Complications include fractures, infections, vascular and neurologic complications following injury and surgery, compartment syndrome, complex regional pain syndrome, deep venous thrombosis, loss of motion and persistent laxity issues. A brief description of these complications ...

  2. The Multiple-markets Problem

    Frankel, Christian

    2015-01-01

    Only few studies in the field of new new economic sociology deal with a simultaneity of multiple markets in the analysis. One central explanation of this situation is limitations inherent in the new new economic sociology. In this review essay I address such limitations as a way to develop research...

  3. Genetics Home Reference: multiple myeloma

    ... This Condition Kahler-Bozzolo disease Kahler disease Kahler's disease medullary plasmacytoma myelomatosis plasma cell dyscrasia plasma cell myelomas Related Information How are genetic conditions and genes named? Additional Information & ... and Rare Diseases Information Center (1 link) Multiple myeloma Additional NIH ...

  4. Multiplicity distributions in QCD cascades

    Multiplicity distributions for hadrons and for jets are studied in QCD parton cascades. The colour dipole formalism is used and earlier results in the double log approximation are generalized to include terms which are suppressed by colour factors or factors of ln s. The result is a set of coupled differential equations, together with appropriate boundary conditions

  5. Genetics Home Reference: multiple sclerosis

    ... factors associated with an increased risk of developing multiple sclerosis include changes in the IL7R gene and environmental factors, such as exposure to the Epstein-Barr virus, low levels of vitamin D, and smoking. The HLA-DRB1 gene belongs ...

  6. [Mandibular lesions in multiple myeloma].

    Scutellari, P N; Orzincolo, C

    1992-03-01

    A review was made of 237 cases of multiple myeloma seen at the Institute of Radiology and Hematology of the Ferrara University from 1984 through 1990. The results showed skeletal involvement of the mandible to be present in 25 patients (10.54%). The diagnosis of multiple myeloma was based on the following criteria: 1) increased number of abnormal, atypical or immature plasma cells in the bone marrow; 2) the presence of a monoclonal protein in the serum or urine; 3) bone lesions consistent with those of myeloma. Symptoms include pain and swelling of the oral cavity, tooth mobility and loss, numbness along the inferior dental nerve, and paresthesia of the lower lip. The typical radiographic appearance is a well-defined "punched-out" lytic defect, solitary or multiple; sometimes, the defect enlarges and appears "bubbly" or septated. Permeative lytic areas, with blurred outlines, are a rare pattern, which is radiologically indistinguishable from skeletal metastases. The involvement of the oral cavity and jaw in multiple myeloma has been often reported in literature: nevertheless, if radiographs of the jaws had been systematically taken in all the cases, its incidence would probably have been much higher than previously suspected. PMID:1579669

  7. Hyper-systolic matrix multiplication

    Lippert, Th.; Petkov, N.; Palazzari, P.; Schilling, K.

    2001-01-01

    A novel parallel algorithm for matrix multiplication is presented. It is based on a 1-D hyper-systolic processor abstraction. The procedure can be implemented on all types of parallel systems. (C) 2001 Elsevier Science B,V. All rights reserved.

  8. Adapting playware to multiple players

    Þorsteinsson, Arnar Tumi; Lund, Henrik Hautop; Mastorakis, Nikos;

    2011-01-01

    With the creation of playware as intelligent hardware and software that creates play, it is possible to adapt the play tool to the individual user, and even to multiple users playing at the same time with the play tool. In this paper, we show how it is possible to implement adaptivity in modular...

  9. Drugs Approved for Multiple Myeloma

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for multiple myeloma and other plasma cell neoplasms. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

  10. Neuromyelitis optica and multiple sclerosis

    Bennett, J. L.; de Seze, J.; Lana-Peixoto, M.;

    2015-01-01

    Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel...

  11. Multiple Intelligences and Business Diversity.

    Martin, Joyce

    2003-01-01

    Results from 97 business students with substantial work histories indicate that the Multiple Intelligence Preference Inventory gives a valid and reliable indication of their preferred intelligences. Awareness of these results is associated with assessments of self and others as knowledge sources. This information can help in recognizing,…

  12. Uric acid in multiple sclerosis

    Koch, M; De Keyser, J

    2006-01-01

    Peroxynitrite, a reactive oxidant formed by the reaction of nitric oxide with superoxide at sites of inflammation in multiple sclerosis (MS), is capable of damaging tissues and cells. Uric acid, a natural scavenger of peroxynitrite, reduces inflammatory demyelination in experimental allergic encepha

  13. Multiple Operator Movements in Hungarian

    Surányi, L.B.

    2003-01-01

    In this thesis I argue for an approach to multiple operator constructions in Hungarian within a radically derivational model which heavily restricts the role of pre-fabricated functional A-bar projections and which holds that it is the verb in this language that carries and projects the relevant ope

  14. The ALICE Forward Multiplicity Detector

    Christensen, Christian Holm; Gulbrandsen, Kristjan; Nielsen, Borge Svane; Sogaard, Carsten

    2007-01-01

    The ALICE Forward Multiplicity Detector (FMD) is a silicon strip detector with 51,200 strips arranged in 5 rings, covering the range $-3.4 < \\eta < 5.1$. It is placed around the beam pipe at small angles to extend the charged particle acceptance of ALICE into the forward regions, not covered by the central barrel detectors.

  15. Laboratory diagnosis of multiple sclerosis

    In 26 patients with multiple sclerosis 100% responded abnormally to magnetic resonance imaging of the brain. Lesions in the posterior fossa were observed in 18 patients. The auditory brain stem response was abnormal in 15 patients, and 22 had abnormal immunoglobulins in the cerebrospinal fluid. The correlation between abnormalities of the auditory brain stem response and the magnetic resonance images was greatest in a subgroup where the two investigations were performed within a ten day interval. Results from magnetic resonance imaging, evoked potentials and cerebrospinal fluid investigations were used to reclassify 13 of 15 patients with clinically ''possible'' or ''probable''multiple sclerosis to a higher level using Poser's criteria. Evoked potentials (the auditory brain stem response in particular) correlated best with clinical multiple sclerosis category. The authors recommend that the magnetic resonance imaging is established as a first-hand investigation in evaluation of multiple sclerosis. Evoked potentials and cerebrospinal fluid investigations may prove to be more specific, however, and these investigations should also be performed as a routine. 23 refs., 2 figs., 2 tabs

  16. Fungible Weights in Multiple Regression

    Waller, Niels G.

    2008-01-01

    Every set of alternate weights (i.e., nonleast squares weights) in a multiple regression analysis with three or more predictors is associated with an infinite class of weights. All members of a given class can be deemed "fungible" because they yield identical "SSE" (sum of squared errors) and R[superscript 2] values. Equations for generating…

  17. Cortical deafness in multiple sclerosis

    Tabira, T.; Tsuji, S; Nagashima, T; T. Nakajima; Kuroiwa, Y

    1981-01-01

    Cortical deafness in a patient with multiple sclerosis is reported. Complete recovery from total deafness was seen following stages of auditory agnosia and pure word deafness. The otological and neurophysiological studies suggested lesions in subcortical white matter. This report stresses the rarity of the condition, its subcortical origin and good prognosis.

  18. Budgeting and controllable cost variances. The case of multiple diagnoses, multiple services, and multiple resources.

    Broyles, R W; Lay, C M

    1982-12-01

    This paper examines an unfavorable cost variance in an institution which employs multiple resources to provide stay specific and ancillary services to patients presenting multiple diagnoses. It partitions the difference between actual and expected costs into components that are the responsibility of an identifiable individual or group of individuals. The analysis demonstrates that the components comprising an unfavorable cost variance are attributable to factor prices, the use of real resources, the mix of patients, and the composition of care provided by the institution. In addition, the interactive effects of these factors are also identified. PMID:7183731

  19. Navigation solution for a multiple satellite and multiple ground architecture

    Leigh, Abraham M.

    This research presents the phased development of an algorithm to plan impulsive orbital maneuvers based on the relative motion between multiple satellites and multiple ground locations. The algorithm leverages the state transition matrix derived from the equations of motion and the equations of variation for the non-spherical Earth and air drag effects. The algorithm determines the impulsive maneuver to achieve the user-defined terminal conditions. The first phase solves for the first burn of an orbital transfer between user-defined altitudes. The optimum trajectory is determined and compared to the first burn in a Hohmann Transfer. The results are expanded to include varying the inclination and eccentricity of the initial orbit. The second phase solves for the minimum time trajectory resulting from a fixed fuel maneuver to transfer a satellite between user-defined altitudes. The results include the transfer time and transfer angle for the minimum time trajectory. The third phase places a satellite within a sphere, of user-defined radius, centered on a non-maneuvering satellite within a constrained time. The results are presented for prograde orbits. An empirical method to determine the optimum DeltaV is provided. The fourth phase places a satellite within the overlapping spheres, of user-defined radii, centered on multiple non-maneuvering satellites, within a constrained time. Empirical methods are presented to determine the separation distance and optimum DeltaV. The final phase culminates by delivering a satellite within the overlapping spheres, centered on multiple non-maneuvering satellites and ground locations, constrained by range and elevation angle, within a constrained time. An empirical model to calculate the optimum DeltaV is shown. All results illustrate mission design trade-offs including ballistic coefficient, orbit inclinations, eccentricity and orbit sizes.

  20. Realization of a gamma multiplicity filter and gamma multiplicity measurements

    A gamma multiplicity filter for the study of reaction mechanism has been realised. It's composed of six NaI(Tl) counters. The flexibility of the geometry allows many configurations. This set up has been tested with gamma radioactive sources and with the 252Cf source to resolve problems of gamma-efficiency of the NaI(Tl) counters and the contamination of neutrons in these detectors. A logical electronic unit (Encodeur) has been constructed and the around electronic has been developped. This gamma multiplicity filter has been coupled with a detector of high resolution Ge(Li), and used in two reactions: 12C + 55Mn at E(12C) = 54 MeV; α + 63Cu at E(α) = 52 MeV. The dominant process is the fusion-evaporation. The compound nucleus 67Ga, is formed at the same excitation energy. The values of multiplicities Msub(γ) have been extracted using a program based on the formalism of W.J. Ockels. The fractionalization of the angular momentum is well observed for some residual nuclei (63Zn, 64Zn, 65Zn), and for each residual nucleus, the average gamma multiplicity is lower with projectile α than that with projectile 12C. For the most strongly output channel p2n, an entry point for the 64Zn has been determined in the reactions. All these observations are in good agreement with those published, in the same region (f-p shell) of nuclei. This set up can be coupled with different central detector as, ''X'', neutrons charged particles detectors, and will be used with the new machine SARA to make a systematic study of transfer of angular momentum to the fragments at 30 MeV/A

  1. Marine and Human Systems: Addressing Multiple Scales and Multiple Stressors

    Hofmann, E. E.; Bundy, A.; Chuenpagdee, R.; Maddison, L.; Svendsen, E.

    2015-12-01

    The Integrated Marine Biogeochemistry and Ecosystem Research (IMBER) project aims to develop a comprehensive understanding of, and predictive capacity of ocean responses to accelerating global change and the consequent effects on the Earth System and human society. Understanding the changing ecology and biogeochemistry of marine ecosystems and their sensitivity and resilience to multiple drivers, pressures and stressors is critical to developing responses that will help reduce the vulnerability of marine-dependent human communities. The cumulative pressure of anthropogenic activities on marine systems is already apparent and is projected to increase in the next decades. Policy- and decision-makers need assessments of the status and trends of marine habitats, species, and ecosystems to promote sustainable human activities in the marine environment, particularly in light of global environmental change and changing social systems and human pressures. The IMBER community recently undertook a synthesis and evaluation of approaches for ecosystem-based marine governance, integrated modeling of marine social-ecological systems, and the social and ecological consequences of changing marine ecosystems. The outcomes of this activity provide assessments of current understanding, indicate approaches needed to predict the effects of multiple stressors, at multiple scales, on marine ecosystems and dependent human populations, and highlight approaches for developing innovative societal responses to changing marine ecosystems.

  2. Multiple teleportation via the partially entangled states

    Wang, Meiyu; Yan, Fengli

    2009-01-01

    We investigate the multiple teleportation with some nonmaximally entangled channels. The efficiencies of two multiple teleportation protocols, the separate multiple teleportation protocol (SMTP) and the global multiple teleportation protocol (GMTP), are calculated. We show that GMTP is more efficient than SMTP.

  3. Shuffle product formulas of multiple zeta values

    Li, Zhonghua; Chen QIN

    2016-01-01

    Using the combinatorial description of shuffle product, we prove or reformulate several shuffle product formulas of multiple zeta values, including a general formula of the shuffle product of two multiple zeta values, some restricted shuffle product formulas of the product of two multiple zeta values, and a restricted shuffle product formula of the product of $n$ multiple zeta values.

  4. Finite Mordell-Tornheim multiple zeta values

    Kamano, Ken

    2016-01-01

    We investigate a finite analogue of the Mordell-Tornheim multiple zeta values (the finite Mordell-Tornheim multiple zeta values). These values can be expressed by a linear combination of finite multiple zeta values, and its rules are described by the shuffle product. As a~corollary, we give a certain relation among finite multiple zeta values.

  5. Multiple Myeloma presenting as Gingival mass

    Shah, Ajaz; Ali, Ashaq; Latoo, Suhail; Ahmad, Irshad

    2010-01-01

    Maxillofacial presentations in patients with multiple myeloma are not uncommon, but multiple myeloma is often overlooked. Because the symptoms are various, it is very difficult to diagnose multiple myeloma in the oral and maxillofacial region. On the basis of the pathologic and clinical findings, the patient was diagnosed with multiple myeloma. Hematologic screening and a radiographic survey further confirmed the diagnosis.

  6. Multiple intelligences: Can they be measured?

    Kirsi Tirri; Petri Nokelainen; Erkki Komulainen

    2013-01-01

    This paper is about issues relating to the assessment of multiple intelligences. The first section introduces the authors’ work on building measures of multiple intelligences and moral sensitivities. It also provides a conceptual definition of multiple intelligences based on Multiple Intelligences theory by Howard Gardner (1983). The second section discusses the context specificity of intelligences and alternative approaches to measuring multiple intelligences. The third section analyses the ...

  7. Plume rise from multiple sources

    A simple enhancement factor for plume rise from multiple sources is proposed and tested against plume-rise observations. For bent-over buoyant plumes, this results in the recommendation that multiple-source rise be calculated as [(N + S)/(1 + S)]/sup 1/3/ times the single-source rise, Δh1, where N is the number of sources and S = 6 (total width of source configuration/N/sup 1/3/ Δh1)/sup 3/2/. For calm conditions a crude but simple method is suggested for predicting the height of plume merger and subsequent behavior which is based on the geometry and velocity variations of a single buoyant plume. Finally, it is suggested that large clusters of buoyant sources might occasionally give rise to concentrated vortices either within the source configuration or just downwind of it

  8. The Multiple Modernities of Europe

    Thomassen, Bjørn

    What Europe? Eric Voegelin on the Mediterranean and the Atlantic modernities. The concept ‘multiple modernities’ has during the last decade established itself in social and political theory, not least due to contributions made by Shmul Eisenstadt. The debate on multiple moderntities has served to...... question certain eurocentric assumptions about modernity and has also reignited the question of European particularity in a world historical perspective. This paper will discuss how ‘Europe’ itself can be considered a result of (at least) two different modernities, as proposed by the political theorist......, Eric Voegelin. Eric Voegelin talked of two spatio-temporal specific modernities, the Mediterranean and the Atlantic modernities. In short, for Voegelin the Atlantic modernity with its breakthroughs in the 17th and 18th centuries was a specific figuration that should not be mistaken for ‘modernity’ but...

  9. Multiple sclerosis - New treatment modalities

    Rocco Totaro

    2015-01-01

    Full Text Available Ever since the introduction of the first disease modifying therapies, the concept of multiple sclerosis treatment algorithms developed ceaselessly. The increasing number of available drugs is paralleled by impelling issue of ensuring the most appropriate treatment to the right patient at the right time. The purpose of this review is to describe novel agents recently approved for multiple sclerosis treatment, namely teriflunomide, alemtuzumab and dimethylfumarate, focusing on mechanism of action, efficacy data in experimental setting, safety and tolerability. The place in therapy of newer treatment implies careful balancing of risk-benefit profile as well as accurate patient selection. Hence the widening of therapeutic arsenal provides greater opportunity for personalized therapy but also entails a complex trade-off between efficacy, tolerability, safety and eventually patient preference.

  10. Molecular mimicry and multiple sclerosis

    Michael Namaka; Michael R. Mulvey; Sabina Kapoor; Leann Simms; Christine Leong; Amy Grossberndt; Michael Prouta; Emma Frost; Farid Esfahani; Andrew Gomori

    2011-01-01

    Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Although the exact underlying mechanism leading to myelin destruction is unknown, the molecular mimicry theory is the most commonly acknowledged elucidation of MS pathology. Although various antigens have been associated with MS induction, this review presents studies focused on key bacterial and viral antigens that lead to the development of MS. The research specific to a molecular mimicry theory of MS via each implicated agent is weak; however, collectively the reports provide credible support for this theory. Given that homologous sequences are not required to lead to antigenic cross-reactivity, it is reasonable to conclude that certain viral and bacterial antigens with 5-10 similar amino acids in sequence can lead to self destruction of similar myelin sequences. Thus, this literature review has provided insight to further the understanding of the etiology of multiple sclerosis.

  11. Learning multiple layers of representation.

    Hinton, Geoffrey E

    2007-10-01

    To achieve its impressive performance in tasks such as speech perception or object recognition, the brain extracts multiple levels of representation from the sensory input. Backpropagation was the first computationally efficient model of how neural networks could learn multiple layers of representation, but it required labeled training data and it did not work well in deep networks. The limitations of backpropagation learning can now be overcome by using multilayer neural networks that contain top-down connections and training them to generate sensory data rather than to classify it. Learning multilayer generative models might seem difficult, but a recent discovery makes it easy to learn nonlinear distributed representations one layer at a time. PMID:17921042

  12. Skeletal surveys in multiple myeloma

    Thirty-three patients with multiple myeloma were studied with serial skeletal surveys, serum immunoglobulin levels, and postabsorptive urinary hydroxyproline (Spot-HYPRO) determinations. Twenty receiving chemotherapy were also followed with skeletal surveys in order to evaluate bone response to treatment. A close association was found between skeletal findings and changes in immunoglubulin levels with positive correlation in 71% of the patients. A similar association was found between skeletal disease and Spot-HYPRO level changes in 65%. Five of 12 patients (42%) with partial or complete clinical response to chemotherapy, demonstrated improvement in the appearance of skeletal lesions. Positive correlation between the roentgenographic changes and clinical markers of myeloma as well as therapeutic response, indicates that skeletal surveys are useful and effective in monitoring patients with multiple myeloma. (orig.)

  13. Multiple sclerosis in magnetic resonance

    The authors analyzed MR examination of 277 patients with multiple sclerosis. White matter hyperintesities in brain were found in 270 of them, in spinal cord in 32. The most frequently they were found in periventricular white matter, in subcortical localization and in the corpus callosum. MR examination allows the estimate the activity of the disease on the basis of the presence of edema around the plaques and their contrast enhancement with Gd-DTPA. About one third of all cases were accompanied by cortical brain atrophy (the most often seen in the frontal lobes), subcortical brain atrophy was less frequent. In about two third of all cases the corpus callosum atrophy was found. MR examination is a highly sensitive method of multiple sclerosis diagnosis, of the assessment of its activity and progression. (author)

  14. Probabilities of multiple quantum teleportation

    Woesler, Richard

    2002-01-01

    Using quantum teleportation a quantum state can be teleported with a certain probability. Here the probabilities for multiple teleportation are derived, i. e. for the case that a teleported quantum state is teleported again or even more than two times, for the two-dimensional case, e. g., for the two orthogonal direcations of the polarization of photons. It is shown that the probability for an exact teleportation, except for an irrelevant phase factor, is 25 %, i. e., surprisingly, this resul...

  15. Iron chelation and multiple sclerosis

    Kelsey J. Weigel; Sharon G. Lynch; Steven M. LeVine

    2014-01-01

    Histochemical and MRI studies have demonstrated that MS (multiple sclerosis) patients have abnormal deposition of iron in both gray and white matter structures. Data is emerging indicating that this iron could partake in pathogenesis by various mechanisms, e.g., promoting the production of reactive oxygen species and enhancing the production of proinflammatory cytokines. Iron chelation therapy could be a viable strategy to block iron-related pathological events or it can confer cellular prote...

  16. Occupational therapy for multiple sclerosis.

    Steultjens, E.M.J.; Dekker, J.; Bouter, L.M.; Cardol, M.; Nes, J.C.M. van de; Ende, C.H.M. van den

    2003-01-01

    Background: Multiple sclerosis (MS) patients are referred to occupational therapy with complaints about fatigue, limb weakness, alteration of upper extremity fine motor coordination, loss of sensation and spasticity that causes limitations in performance of activities of daily living and social participation. The primary purpose of occupational therapy is to enable individuals to participate in self-care, work and leisure activities that they want or need to perform. Objectives: to determine ...

  17. Introductory remarks on complex multiplication

    Harvey Cohn

    1982-12-01

    Full Text Available Complex multiplication in its simplest form is a geometric tiling property. In its advanced form it is a unifying motivation of classical mathematics from elliptic integrals to number theory; and it is still of active interest. This interrelation is explored in an introductory expository fashion with emphasis on a central historical problem, the modular equation between j(z and j(2z.

  18. The Theory of Multiple Peeling

    Pugno, Nicola M

    2009-01-01

    In this paper we solve the multiple peeling problem by applying a fracture mechanics approach to a complex system of films, adhering to the substrate and having a common hinge, where the pulling force is applied. The simplest V-shaped system, consisting of two identical peeling tapes is considered as a case study (to be solved coupling six nonlinear equations); an optimal peeling angle, at which adhesion is maximal, is discovered.

  19. Multiple imaging by gravitational waves

    Faraoni, Valerio

    1997-01-01

    Gravitational waves act like lenses for the light propagating through them. This phenomenon is described using the vector formalism employed for ordinary gravitational lenses, which was proved to be applicable also to a non-stationary spacetime, with the appropriate modifications. In order to have multiple imaging, an approximate condition analogous to that for ordinary gravitational lenses must be satisfied. Certain astrophysical sources of gravitational waves satisfy this condition, while t...

  20. Multiplicity of monetary steady states

    Ryoji Hiraguchi; Keiichiro Kobayashi

    2014-01-01

    In the Lagos-Wright model of money, monetary frictions alone cannot be a source of equilibrium multiplicity. However, the conclusion depends on the assumption that the agents always enter the centralized market after completing a transaction in the decentralized markets. In this paper, we investigate a monetary model in which the centralized market opens once, but the decentralized markets open twice in each period. We show that as the sellers money balances affect the buyers problem in the f...

  1. Goiter and Multiple Food Allergies

    Stefanie Leniszewski; Richard Mauseth

    2009-01-01

    Severe iodine deficiency results in impaired thyroid hormone synthesis and thyroid enlargement. In the United States, adequate iodine intake is a concern for women of childbearing age and pregnant women. Beyond this high risk group iodine deficiency is not considered to be a significant problem. This case report describes a 12-year-old male with severe iodine deficiency disorder (IDD) resulting from restricted dietary intake due to multiple food allergies. We describe iodine replacement for t...

  2. Goiter and Multiple Food Allergies

    Leniszewski Stefanie; Mauseth Richard

    2009-01-01

    Severe iodine deficiency results in impaired thyroid hormone synthesis and thyroid enlargement. In the United States, adequate iodine intake is a concern for women of childbearing age and pregnant women. Beyond this high risk group iodine deficiency is not considered to be a significant problem. This case report describes a 12-year-old male with severe iodine deficiency disorder (IDD) resulting from restricted dietary intake due to multiple food allergies. We describe iodine replacement for ...

  3. Nutrition Facts in Multiple Sclerosis

    Riccio, Paolo; Rossano, Rocco

    2015-01-01

    The question whether dietary habits and lifestyle have influence on the course of multiple sclerosis (MS) is still a matter of debate, and at present, MS therapy is not associated with any information on diet and lifestyle. Here we show that dietary factors and lifestyle may exacerbate or ameliorate MS symptoms by modulating the inflammatory status of the disease both in relapsing-remitting MS and in primary-progressive MS. This is achieved by controlling both the metabolic and inflammatory p...

  4. Multiple-Segment Climbing Robots

    Kerley, James; May, Edward; Eklund, Wayne

    1994-01-01

    Multiple-segment climbing robots developed to perform such tasks as inspection, sandblasting, welding, and painting on towers and other structures. Look and move like caterpillars. Video camera mounted on one of segments rotated to desired viewing angle. Used in remote inspection of structure, to view motion of robot and/or provides video feedback for control of motion, and/or to guide operation of head mounted on foremost segment with motorized actuators.

  5. Cerebral palsy and multiple births.

    Pharoah, P. O.; Cooke, T

    1996-01-01

    AIM: To compare the birthweight specific prevalence of cerebral palsy in singleton and multiple births. METHODS: Registered births of babies with cerebral palsy born to mothers resident in the counties of Merseyside and Cheshire during the period 1982 to 1989 were ascertained. RESULTS: The crude prevalence of cerebral palsy was 2.3 per 1000 infant survivors in singletons, 12.6 in twins, and 44.8 in triplets. The prevalence of cerebral palsy rose with decreasing birthweight. The birthweight sp...

  6. Resistant Multiple Sparse Canonical Correlation

    Coleman, Jacob; Replogle, Joseph; Chandler, Gabriel; Hardin, Johanna

    2014-01-01

    Canonical Correlation Analysis (CCA) is a multivariate technique that takes two datasets and forms the most highly correlated possible pairs of linear combinations between them. Each subsequent pair of linear combinations is orthogonal to the preceding pair, meaning that new information is gleaned from each pair. By looking at the magnitude of coefficient values, we can find out which variables can be grouped together, thus better understanding multiple interactions that are otherwise difficu...

  7. EU Law and Multiple Discrimination

    Nielsen, Ruth

    2006-01-01

    In EU law, nationality and gender were the only equality issues on the legal agenda from the outset in 1958 and for about 40 years. Multiple discrimination was not addressed until the 1990's. The intersectionality approach which has been widely discussed outside Europe has mainly been used with a view to gendermainstreaming the fight against other kinds of discrimination (on grounds of ethnic origin, age, etc).

  8. EU Law and Multiple Discrimination

    Nielsen, Ruth

    2006-01-01

    In EU law, nationality and gender were the only equality issues on the legal agenda from the outset in 1958 and for about 40 years. Multiple discrimination was not addressed until the 1990's. The intersectionality approach which has been widely discussed outside Europe has mainly been used with a...... view to gendermainstreaming the fight against other kinds of discrimination (on grounds of ethnic origin, age, etc)....

  9. Computational Reasoning across Multiple Models

    Tsafnat, Guy; Coiera, Enrico W.

    2009-01-01

    Computational support of clinical decisions frequently requires the integration of data in a variety of formats and from multiple sources and domains. Some impressive multiscale computational models of biological phenomena have been developed as part of the study of disease and healthcare systems. One can now contemplate harnessing these models arising from computational biology and using highly interconnected clinical data to support clinical decision-making. Indeed, understanding how to bui...

  10. Cell Therapy for Multiple Sclerosis

    Ben-Hur, Tamir

    2011-01-01

    The spontaneous recovery observed in the early stages of multiple sclerosis (MS) is substituted with a later progressive course and failure of endogenous processes of repair and remyelination. Although this is the basic rationale for cell therapy, it is not clear yet to what degree the MS brain is amenable for repair and whether cell therapy has an advantage in comparison to other strategies to enhance endogenous remyelination. Central to the promise of stem cell therapy is the therapeutic pl...

  11. Vitamin D and Multiple Sclerosis

    Raghuwanshi, Anita; Joshi, Sneha S.; Christakos, Sylvia

    2008-01-01

    Vitamin D is a principal regulator of calcium homeostasis. However, recent evidence has indicated that vitamin D can have numerous other physiological functions including inhibition of proliferation of a number of malignant cells including breast and prostate cancer cells and protection against certain immune mediated disorders including multiple sclerosis (MS). The geographic incidence of MS indicates an increase in MS with a decrease in sunlight exposure. Since vitamin D is produced in the ...

  12. Pharmacogenetic studies in multiple myeloma

    Corthals, Sophie

    2011-01-01

    textabstractMultiple myeloma (MM) is a malignant plasma cell disorder that accounts for approximately 10% of all hematologic cancers.1-2 MM is characterized by clonal proliferation of malignant plasma cells in the bone marrow, which secrete a homogeneous immunoglobulin product known as monoclonal (M) protein or paraprotein. Typical features of MM include osteolytic bone lesions, renal disease, anemia, hypercalcemia and immunodeficiency.3 The pathological development of MM is a multistep proce...

  13. Multiple risky securities valuation I.

    ilya, gikhman

    2008-01-01

    In this paper we develop an approach to valuation of a multiple names security portfolio. The goal of the paper to present pricing and calculation of the risk characteristics of the corporate debt based on randomization of the historical data of portfolio assets. Our approach close but it does not coincide with the reduced form interpretation of the credit risk. Based on stochastic interpretation of the default it follows that the market price of a bond is a stochastic pro...

  14. Cognitive Dysfunction in Multiple Sclerosis

    Joana eGuimarães; Maria José eSá

    2012-01-01

    In Multiple Sclerosis (MS) prevalence studies of community and clinical samples, indicate that 45–60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes par...

  15. Multiple Regressive Model Adaptive Control

    Garipov, Emil; Stoilkov, Teodor; Kalaykov, Ivan

    2008-01-01

    The essence of the ideas applied to this text consists in the development of the strategy for control of the arbitrary in complexity continuous plant by means of a set of discrete timeinvariant linear controllers. Their number and tuned parameters correspond to the number and parameters of the linear time-invariant regressive models in the model bank, which approximate the complex plant dynamics in different operating points. Described strategy is known as Multiple Regressive Model Adaptive C...

  16. Cranial Neuropathy in Multiple Sclerosis

    Mine Hayriye Sorgun; Bilge Koçer; Funda Kaplan; Nesrin Yılmaz; Nezih Yücemen; Canan Yücesan

    2011-01-01

    OBJECTIVE: It has been reported that cranial neuropathy findings could be seen in the neurologic examination of multiple sclerosis (MS) patients, although brain magnetic resonance imaging (MRI) may not reveal any lesion responsible for the cranial nerve involvement. The aim of this study was to determine the frequency of brainstem and cranial nerve involvement, except for olfactory and optic nerves, during MS attacks, and to investigate the rate of an available explanation for the cranial neu...

  17. Teamwork in controlling multiple robots

    Gao, Fei; Bertuccelli, Luca F.; Cummings, M.L.

    2012-01-01

    Simultaneously controlling increasing numbers of robots requires multiple operators working together as a team. Helping operators allocate attention among different robots and determining how to construct the human-robot team to promote performance and reduce workload are critical questions that must be answered in these settings. To this end, we investigated the effect of team structure and search guidance on operators' performance, subjective workload, work processes and communication. To i...

  18. Dyadic Patterns in Multiple Networks

    Ostoic, Antonio Rivero

    Seven dyadic configuration classes for the analysis of multiple networks are introduced in this paper. Each configuration is a relational bundle pattern resulting from the mixture of the direction and the types of tie between a pair of actors. Then a bundle census is performed to an empirical...... network made of three kinds of relations, and the algorithm used for the bundle class detection is presented with a generalization of networks up to r types of tie....

  19. Dyadic Patterns in Multiple Networks

    Ostoic, Antonio Rivero

    2011-01-01

    Seven dyadic configuration classes for the analysis of multiple networks are introduced in this paper. Each configuration is a relational bundle pattern resulting from the mixture of the direction and the types of tie between a pair of actors. Then a bundle census is performed to an empirical...... network made of three kinds of relations, and the algorithm used for the bundle class detection is presented with a generalization of networks up to r types of tie....

  20. Chaos and multiple photon absorption

    An anharmonic vibrational mode of a molecule, driven by an intense infrared laser and coupled to a quasi-continuum of background modes, is found to undergo chaotic oscillations. This chaos leads to predominantly fluence-dependent rather than intensity-dependent multiple-photon absorption, as is found experimentally. The loss of coherence is associated with the decay of temporal correlation of background-mode oscillations

  1. Multiple Shareholders and Control Contests

    Bloch, Francis; Hege, Ulrich

    2003-01-01

    We consider the allocation of corporate control in a company with two large and a continuum of small shareholders. Control is determined in a shareholders' meeting, where the large shareholders submit competing proposals in order to attract the vote of small shareholders. The presence of multiple shareholders reduces private benefits through competition for control. In the optimal ownership structure, the more efficient blockholder will hold just enough shares to gain control, but a large fra...

  2. Multiple sclerosis and birth order.

    James, W. H.

    1984-01-01

    Studies on the birth order of patients with multiple sclerosis have yielded contradictory conclusions. Most of the sets of data, however, have been tested by biased tests. Data that have been submitted to unbiased tests seem to suggest that cases are more likely to occur in early birth ranks. This should be tested on further samples and some comments are offered on how this should be done.

  3. Resistant multiple sparse canonical correlation.

    Coleman, Jacob; Replogle, Joseph; Chandler, Gabriel; Hardin, Johanna

    2016-04-01

    Canonical correlation analysis (CCA) is a multivariate technique that takes two datasets and forms the most highly correlated possible pairs of linear combinations between them. Each subsequent pair of linear combinations is orthogonal to the preceding pair, meaning that new information is gleaned from each pair. By looking at the magnitude of coefficient values, we can find out which variables can be grouped together, thus better understanding multiple interactions that are otherwise difficult to compute or grasp intuitively. CCA appears to have quite powerful applications to high-throughput data, as we can use it to discover, for example, relationships between gene expression and gene copy number variation. One of the biggest problems of CCA is that the number of variables (often upwards of 10,000) makes biological interpretation of linear combinations nearly impossible. To limit variable output, we have employed a method known as sparse canonical correlation analysis (SCCA), while adding estimation which is resistant to extreme observations or other types of deviant data. In this paper, we have demonstrated the success of resistant estimation in variable selection using SCCA. Additionally, we have used SCCA to find multiple canonical pairs for extended knowledge about the datasets at hand. Again, using resistant estimators provided more accurate estimates than standard estimators in the multiple canonical correlation setting. R code is available and documented at https://github.com/hardin47/rmscca. PMID:26963062

  4. Multiple primary cancers: An enigma

    Amitabh Jena

    2016-01-01

    Full Text Available Background: Incidence of multiple primary cancers though uncommon, is being frequently reported now-a-days owing to better diagnostic techniques, the prolonged life span and the increased incidence of long-term survival of cancer patients. Materials and Methods: This is a retrospective study. Cases of multiple malignancies diagnosed histopathologically were retrieved from the archives of department of surgical oncology. Clinical data were obtained from the medical records. They were categorized as synchronous malignancies if the interval between them was less or equal to 6 months and metachronous, if the interval was more than 6 months. Results: A total of 13 cases were encountered in the 5 year study period. Out of them two were in the metachronous category and the rest were synchronous as the 2nd malignancy was detected mostly during clinical evaluation of the patients for the primary malignancy. There was female predominance with age range being 43-68 years. Majority of the cases were in the 7th decade. The most common organ involved was breast, followed by cervix. Apart from bilateral breast malignancies, there were combinations like breast with uterine endometrial carcinoma, cervical carcinoma and even papillary thyroid carcinoma. Conclusion: Detection of multiple primary malignancies is becoming increasingly common in day-to-day practice. Greater awareness of this is required among both cancer patients and their treating clinicians.

  5. Magnetic resonance in multiple sclerosis

    Magnetic Resonance Imaging was performed in more than 200 patients with clinical suspicion or knowledge of Multiple Sclerosis. One hundred and forty-seven (60 males and 87 females) had MR evidence of multiple sclerosis lesions. The MR signal of demyelinating plaques characteristically has prolonged T1 and T2 relaxation times and the T2-weighted spin-echo sequences are generally superior to the T1-weighted images because the lesions are better visualized as areas of increased signal intensity. MR is also able to detect plaques in the brainstem, cerebellum and within the cervical spinal cord. MR appears to be an important, non-invasive method for the diagnosis of Multiple Sclerosis and has proven to be diagnostically superior to CT, evoked potentials (EP) and CSF examination. In a selected group of 30 patients, with the whole battery of the relevant MS studies, MR was positive in 100%, CT in 33,3%, EP in 56% and CSF examination in 60%. In patients clinically presenting only with signs of spinal cord involvement or optic neuritis or when the clinical presentation is uncertain MR has proven to be a very useful diagnostic tool for diagnosis of MS by demonstrating unsuspected lesions in the cerebral hemispheres. (orig.)

  6. Multiple-illumination photoacoustic tomography

    Barber, Quinn M.; Zemp, Roger J.

    2016-03-01

    Previously we described the potential for multiple illumination photoacoustic tomography to provide quantitative reconstructions, however this work used only simulated data. We have developed a custom photoacoustic-ultrasound tomography system capable of multiple illuminations and parallel acquisition from a 256 element 5 MHz transducer ring array with 8-cm diameter. The multiple illumination scheme uses a free-space light delivery geometry where a rotational stage scans a pulsed laser beam onto different incident locations around the sample. For each illumination location a photoacoustic image is reconstructed using a modified backprojection algorithm. Images from different source locations have the potential to be combined to form an improved deep-tissue image using our previously developed iterative algorithms. We complement the photoacoustic imaging data with unique ultrasound imaging data. Most previous ultrasound tomography methods have used migration algorithms, iterative ray-based analysis, wave-equation modeling, or frequency-based algorithms that all demand large amounts of data and computational power. We propose a new UST method that offers isotropic resolution, provides scattering contrast, as well as the potential for measuring ultrasound scattering anisotropy and decoupling density and compressibility contributions. The imaging system is driven by a Verasonics scan engine and programmed for both ultrasound and photoacoustic imaging modes. Resolution has been measured to be 150 μm for ultrasound and 200 μm for photoacoustic images. Imaging capabilities are demonstrated on phantoms with custom-tailored ultrasound scattering and optical properties, as well as in murine models.

  7. Feature Selection Methods for Early Predictive Biomarker Discovery Using Untargeted Metabolomic Data.

    Grissa, Dhouha; Pétéra, Mélanie; Brandolini, Marion; Napoli, Amedeo; Comte, Blandine; Pujos-Guillot, Estelle

    2016-01-01

    Untargeted metabolomics is a powerful phenotyping tool for better understanding biological mechanisms involved in human pathology development and identifying early predictive biomarkers. This approach, based on multiple analytical platforms, such as mass spectrometry (MS), chemometrics and bioinformatics, generates massive and complex data that need appropriate analyses to extract the biologically meaningful information. Despite various tools available, it is still a challenge to handle such large and noisy datasets with limited number of individuals without risking overfitting. Moreover, when the objective is focused on the identification of early predictive markers of clinical outcome, few years before occurrence, it becomes essential to use the appropriate algorithms and workflow to be able to discover subtle effects among this large amount of data. In this context, this work consists in studying a workflow describing the general feature selection process, using knowledge discovery and data mining methodologies to propose advanced solutions for predictive biomarker discovery. The strategy was focused on evaluating a combination of numeric-symbolic approaches for feature selection with the objective of obtaining the best combination of metabolites producing an effective and accurate predictive model. Relying first on numerical approaches, and especially on machine learning methods (SVM-RFE, RF, RF-RFE) and on univariate statistical analyses (ANOVA), a comparative study was performed on an original metabolomic dataset and reduced subsets. As resampling method, LOOCV was applied to minimize the risk of overfitting. The best k-features obtained with different scores of importance from the combination of these different approaches were compared and allowed determining the variable stabilities using Formal Concept Analysis. The results revealed the interest of RF-Gini combined with ANOVA for feature selection as these two complementary methods allowed selecting the 48

  8. Equity Valuation with the Use of Multiples

    Stauropoulos Antonios; Samaras Ioannis; Arsenos Panagiotis

    2012-01-01

    Problem statement: Equity valuation with the use of multiples is widely used by academics and practitioners concerning its functionality. This study aims to explore the sensitivity of three multiples in terms of bias. Approach: The three multiples under consideration are the Price-To-Sales (P/S) multiple, the Price-To-Book value of equity (P/B) multiple and the Price-To-Earnings (P/E) multiple using both current and one-year-ahead earnings forecasts. Results: According to the empirical result...

  9. Radiological diagnostics of multiple myeloma

    Robust and reliable imaging methods are required to estimate the skeletal tumor load in multiple myeloma, as well as for the diagnosis of extraskeletal manifestations. Imaging also plays an essential role in the assessment of fracture risk and of vertebral fractures. The conventional skeletal survey has been the gold standard in the imaging of multiple myeloma for many years. Other modalities which have been investigated and are in use are whole-body computed tomography (WBCT), 18F-fluorodeoxyglucose positron emission tomography computed tomography (FDG PET-CT) and whole-body magnetic resonance imaging (WBMRI). These techniques are able to depict both mineralized bone and the bone marrow with a high sensitivity for myeloma lesions. Several studies have shown that cross-sectional imaging is superior to the skeletal survey in the detection of myeloma lesions and WBMRI has been shown to be significantly more sensitive than WBCT for the detection of focal myeloma lesions as well as for diffuse infiltration. The FDG PET-CT technique has a sensitivity comparable to WBMRI. Due to the higher sensitivity in the detection of myeloma lesions WBCT and WBMRI should replace the skeletal survey. A WBCT should be performed if there is suspicion of multiple myeloma. If no focal lesions are found WBMRI or at least MRI of the spine and pelvis should be additionally performed if available. If WBMRI has been initially performed and focal lesions are present, an additional WBCT may be performed to assess the extent of bone destruction and fracture risk. In cases of monoclonal gammopathy of undetermined significance (MGUS), solitary and smoldering myeloma, a WBMRI, if available, should be performed in addition to WBCT. (orig.)

  10. Multiple enchondromatosis in the dog

    The clinical and radiological findings of three related Miniature Poodles with multiple enchondromatosis (Ollier's disease) are presented. Persisting, in part ossified growth plate cartilage foci were found bilaterally in the humerus, radius, ulna, femur, tibia and fibula of each dog and in one dog in some metacarpal and metatarsal bones. The ribs and many vertebral bodies were also affected. There was evidently no bone formation in the sternebrae. All three dogs first attracted attention at the ages of four to six months, with spontaneous bilateral femoral neck fractures. The mode of inheritance of the condition is not yet clear, but based on the known pedigree data a dominant effect appears unlikely

  11. Multiple Segmentation of Image Stacks

    Smets, Jonathan; Jaeger, Manfred

    2014-01-01

    We propose a method for the simultaneous construction of multiple image segmentations by combining a recently proposed “convolution of mixtures of Gaussians” model with a multi-layer hidden Markov random field structure. The resulting method constructs for a single image several, alternative...... segmentations that capture different structural elements of the image. We also apply the method to collections of images with identical pixel dimensions, which we call image stacks. Here it turns out that the method is able to both identify groups of similar images in the stack, and to provide segmentations...

  12. Multiple imaging radiography at LNLS

    Hoennicke, M.G. [LORXI, Departamento de Fisica, Universidade Federal do Parana, Caixa Postal 19091, 81531-990 Curitiba (Brazil)], E-mail: marcelohonnicke@yahoo.com.br; Cusatis, C. [LORXI, Departamento de Fisica, Universidade Federal do Parana, Caixa Postal 19091, 81531-990 Curitiba(Brazil); Antunes, A. [Departamento de Fisica Aplicada, Instituto de Fisica, Universidade de Sao Paulo, Caixa Postal 66318, 05315-970 Sao Paulo (Brazil); Safatle, A.M.V.; Barros, P.S.M. [Laboratorio de Oftalmologia Experimental e Comparativa, Departamento de Cirurgia, Faculdade de Medicina Veterinaria, Universidade de Sao Paulo, 05508-900 Sao Paulo (Brazil); Morelhao, S.L. [Departamento de Fisica Aplicada, Instituto de Fisica, Universidade de Sao Paulo, Caixa Postal 66318, 05315-970 Sao Paulo (Brazil)

    2008-01-11

    An analyzer-based X-ray phase-contrast imaging (ABI) setup has been mounted at the Brazilian Synchrotron Light Laboratory (LNLS) for multiple imaging radiography (MIR) purposes. The algorithm employed for treating the MIR data collected at LNLS is described, and its reliability in extracting the distinct types of contrast that can be obtained with MIR is demonstrated by analyzing a test sample (thin polyamide wire). As a practical application, the possibility of studying ophthalmic tissues, corneal sequestra in this case, via MIR is investigated.

  13. Multiple chromosomes of Azotobacter vinelandii.

    1989-01-01

    The number of copies of the genes leuB, nifH, nifD, and nifK per cell of Azotobacter vinelandii has been determined to be about 80. A beta-lactamase gene was integrated into the A. vinelandii chromosome by single-point crossover. Subsequently, we have been able to detect nearly 80 copies of this beta-lactamase gene per cell of A. vinelandii when cultured for a large number of generations in the presence of ampicillin. The multiple copies of the beta-lactamase gene do not seem to be present on...

  14. Multiple intracranial dural arteriovenous fistula

    Abdolkarim Rahmanian

    2013-01-01

    Full Text Available Dural arteriovenous fistula (DAVF is also known as dural arteriovenous malformation. Two forms of DAVF have been introduced, however, here we present an exceptional case of DAVF with unique origin and drainage. In this study, we present a rare case of multiple DAVFs in a 50 year old man with right parietal intraparenchymal hemorrhage. MRI showed two round right parieto-occipital masses with flow void intensity adjacent to superior sagittal sinus (SSS. Another pathology connected to SSS by an abnormal cortical vein was detected anterior to first lesion. This study showed that both DAVFs were simultaneously drained in SSS in our patient.

  15. Moliere multiple scattering theory revisited

    Tarasov, Alexander

    2012-01-01

    We have received the rigorous relations between the screening parameters of the Moliere multiple scattering theory, instead of the approximate one obtained in the original paper by Moliere. We also calculated the relative Coulomb corrections to the first Born screening angle in the range from Z=4 to Z=82, and showed that their maximum values comprise the order of 40 percent. Additionally, we evaluated absolute and relative accuracies of the Moliere theory in determining the screening angle and have concluded that for Z~80 they are about 20, and 34 percents, respectively.

  16. Evolutionary Processes in Multiple Systems

    Eggleton, P P; Kisseleva-Eggleton, L

    2006-02-14

    There are several ways in which triple stars can evolve in somewhat unusual ways. They discuss two situations where Case A Roche-lobe overflow, followed by a merger, can produce anomalous wide binaries such as {gamma} Per; and Kozai cycles in triples with non-parallel orbits, which can produce merged rapidly-rotating stars like AB Dor, and which can also lead to the delayed ejection of one component of a multiple, as may have been observed in T Tau in 1998.

  17. Multiple q-Zeta Brackets

    Wadim Zudilin

    2015-01-01

    The multiple zeta values (MZVs) possess a rich algebraic structure of algebraic relations, which is conjecturally determined by two different (shuffle and stuffle) products of a certain algebra of noncommutative words. In a recent work, Bachmann constructed a $q$-analogue of the MZVs -- the so-called bi-brackets -- for which the two products are dual to each other, in a very natural way. We overview Bachmann's construction and discuss the radial asymptotics of the bi-brackets, its links to th...

  18. Multiple q-Zeta Brackets

    Wadim Zudilin

    2015-03-01

    Full Text Available The multiple zeta values (MZVs possess a rich algebraic structure of algebraic relations, which is conjecturally determined by two different (shuffle and stuffle products of a certain algebra of noncommutative words. In a recent work, Bachmann constructed a q-analogue of the MZVs—the so-called bi-brackets—for which the two products are dual to each other, in a very natural way. We overview Bachmann’s construction and discuss the radial asymptotics of the bi-brackets, its links to the MZVs, and related linear (independence questions of the q-analogue.

  19. Multiple piece turbine rotor blade

    Jones, Russell B; Fedock, John A

    2013-05-21

    A multiple piece turbine rotor blade with a shell having an airfoil shape and secured between a spar and a platform with the spar including a tip end piece. a snap ring fits around the spar and abuts against the spar tip end piece on a top side and abuts against a shell on the bottom side so that the centrifugal loads from the shell is passed through the snap ring and into the spar and not through a tip cap dovetail slot and projection structure.

  20. Cloaks with multiple invisible regions

    This paper proposes a general method of extending the effective invisible regions for both the shell-like interior cloak and the complementary media exterior cloak, without affecting their original cloaking regions. The proposed method is based on layered spatial mapping instead of the intact mapping. Certain interior or exterior invisible regions can be obtained by properly using a compressed or folded transformation in each space layer. Therefore, the proposal enables the as-designed cloaks to provide multiple invisible regions of different types simultaneously. Thus objects can be hidden in the interior cavity and/or in the exterior space, or even be embedded between the cloaking shells

  1. Ordering multiple soft gluon emissions

    Ángeles-Martínez, René; Seymour, Michael H

    2016-01-01

    We present an expression for the QCD amplitude for a general hard scattering process with any number of soft gluon emissions, to one-loop accuracy. The amplitude is written in two different but equivalent ways: as a product of operators ordered in dipole transverse momentum and as a product of loop-expanded currents. We hope that these results will help in the development of an all-orders algorithm for multiple emissions that includes the full colour structure and both the real and imaginary contributions to the amplitude.

  2. Vitamin D and multiple sclerosis

    Asghar Amini Harandi; Ali Amini Harandi; Hossein Pakdaman; Mohammad Ali Sahraian

    2014-01-01

    Multiple sclerosis (MS) is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immune system is under the influence of vitamin D which as a modulator of immune response could play a role in autoimmune diseases including MS. Deficiency of vitamin D or variations in DNA sequence (po...

  3. Code division multiple access (CDMA)

    Buehrer, R Michael

    2006-01-01

    This book covers the basic aspects of Code Division Multiple Access or CDMA. It begins with an introduction to the basic ideas behind fixed and random access systems in order to demonstrate the difference between CDMA and the more widely understood TDMA, FDMA or CSMA. Secondly, a review of basic spread spectrum techniques are presented which are used in CDMA systems including direct sequence, frequency-hopping and time-hopping approaches. The basic concept of CDMA is presented, followed by the four basic principles of CDMA systems that impact their performance: interference averaging, universa

  4. Very high multiplicity hadron processes

    The paper contains a description of a first attempt to understand the extremely inelastic high energy hadron collisions, when the multiplicity of produced hadrons considerably exceeds its mean value. Problems with existing model predictions are discussed. The real-time finite-temperature S-matrix theory is built to have a possibility to find model-free predictions. This allows one to include the statistical effects into consideration and build the phenomenology. The questions to experiment are formulated at the very end of the paper

  5. Therapeutic advancements in multiple myeloma

    Alessandro eGozzetti

    2014-09-01

    Full Text Available Multiple myeloma survival has significantly improved in latest years, due to a broad spectrum of novel agents available for treatment. The introduction of thalidomide, bortezomib and lenalidomide together with autologous stem cell transplantation has dramatically prolonged complete remissions rate, progression free survivals resulting ultimately in prolonged survivals in myeloma patients. Moreover, novel strategies of treatment such as consolidation and maintenance are being used to implement responses. A number of new drugs such as carfilzomib and pomalidomide are already in clinical practice, and new kids on the block are entering, making the future of myeloma patients brighter.

  6. The application of stata multiple inputation command to analyze design of experiments with multiple regression

    Clara Novoa; Suleima Alkusari

    2012-01-01

    This talk exemplifies the application of the multiple imputation technique available in STATA to analize a design of experiments with multiple responses and missing data. No imputation and multiple imputation methodologies are compared.

  7. Multiple endocrine neoplasia type 1

    R V Thakker

    2012-01-01

    Full Text Available Multiple endocrine neoplasia type 1 (MEN1 is characterized by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumors. Some patients may also develop carcinoid tumors, adrenocortical tumors, facial angiofibromas, collagenomas, and lipomas. MEN1 is an autosomal-dominant disorder, due to mutations in the tumor suppressor gene MEN1, which encodes a 610 amino acid protein, menin. Thus, the finding of MEN1 in a patient has important implications for family members because first-degree relatives have a 50% risk of developing the disease and can often be identified by MEN1 mutational analysis. Patients with MEN1 have a decreased life-expectancy and the outcomes of current treatments, which are generally similar to that for the respective tumors occurring in non-MEN1 patients, are not as successful because of multiple tumors, which may be larger, more aggressive, and resistant to treatment, and the concurrence of metastases. The prognosis for MEN1 patients might be improved by pre-symptomatic tumor detection and undertaking treatment specific for MEN1-tumors. Thus, it is recommended that MEN1 patients and their families should be cared for by multi-disciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors.

  8. Endovascular interventions for multiple trauma

    In recent years interventional radiology has significantly changed the management of injured patients with multiple trauma. Currently nearly all vessels can be reached within a reasonably short time with the help of specially preshaped catheters and guide wires to achieve bleeding control of arterial und venous bleeding. Whereas bleeding control formerly required extensive open surgery, current interventional methods allow temporary vessel occlusion (occlusion balloons), permanent embolization and stenting. In injured patients with multiple trauma preinterventional procedural planning is performed with the help of multidetector computed tomography whenever possible. Interventional radiology not only allows minimization of therapeutic trauma but also a considerably shorter treatment time. Interventional bleeding control has developed into a standard method in the management of vascular trauma of the chest and abdomen as well as in vascular injuries of the upper and lower extremities when open surgical access is associated with increased risk. Additionally, pelvic trauma, vascular trauma of the superior thoracic aperture and parenchymal arterial lacerations of organs that can be at least partially preserved are primarily managed by interventional methods. In an interdisciplinary setting interventional radiology provides a safe and efficient means of rapid bleeding control in nearly all vascular territories in addition to open surgical access. (orig.)

  9. Evolution of multiple supernova remnants

    Vasiliev, Evgenii O; Bondarev, Roman; Shchekinov, Yuri

    2014-01-01

    Heating of the interstellar medium by multiple supernovae (SNe) explosions is at the heart of producing galaxy-scale outflows in starburst galaxies. Standard models of outflows assume a high efficiency of SNe in heating the gas to X-ray emitting temperatures and to fill the central region of starburst with hot gas, in order to launch vigorous outflows. We study the efficiency of multiple SNe in heating the interstellar medium (ISM) and filling the volume with gas of high temperatures, with 2-D and 3-D hydrodynamic simulations. We argue that SNe have to be clustered in space and time (and be coherent) in order to compensate for the radiative loss. In particular, we find that in coherent cases, the filling factor of gas with $3 \\times 10^6$ K can be at the most $\\le 0.3$ and the total heating efficiency $\\le 0.3$, for gas with density $1$ cm$^{-3}$ and $0.1\\hbox{--}1$ Z$_\\odot$. The heating efficiency and filling factors are much smaller in incoherent cases. Comparing our results to the commonly adopted efficie...

  10. Multiple sclerosis and sexual dysfunction

    Zhen-Ni Guo; Si-Yuan He; Hong-Liang Zhang; Jiang Wu; Yi Yang

    2012-01-01

    Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system characterized by episodic and progressive neurologic dysfunction resulting from inflammatory and autoimmune reactions.The underlying pathogenesis of MS remains largely unclear.However,it is currently accepted as a T cell-mediated autoimmune disease.Among other clinical manifestations,sexual dysfunction (SD) is a painful but still underreported and underdiagnosed symptom of the disorder.SD in MS patients may result from a complex set of conditions and may be associated with multiple anatomic,physiologic,biologic,medical and psychological factors.SD arises primarily from lesions affecting the neural pathways involved in physiologic function.In addition,psychological factors,the side effects of medications and physical symptoms such as fatigue,muscular weakness,menstrual changes,pain and concerns about bladder and bowel incontinence may also be involved.Since MS primarily affects young people,SD secondary to MS may have a great impact on quality of life.Thus,maintaining a healthy sexual life with MS is an important priority.The treatment of SD requires multidisciplinary teamwork and cooperation among specialists,individual patients,partners and the society.

  11. Multiple production in peripheral interaction

    Multiplicity distribution at particle production in the multiperipheral shower is of the Poisson form, with the average particle number increasing as ln s. However production of several multiperipheral showers simultaneously, due to a dissociation of the colliding particles, is possible. The subject of the paper is this effect, resulting in a considerable broadening with the energy rise, of the particle multiplicity distributions. The results by Abramovsky, Gribov, Kancheli enable one to express the probability of a simultaneous production of several showers on terms of the cut contribution to the elastic scattering amplitude, that is known presently with a reasonable accuracy from handling of experimental data on basis of the complex angular momentum theory. This approach makes it possible to calculate the topological cross sections sigmasub(n)(s)=F(n) for production of n particles for some concrete cases. The NN, NN, and π+-N(K+-N) collisions are considered in detail . The calculations are fulfilled with a somewhat better accuracy than in the previous papers with account for the contributions from the non-Pomeronic singularities. The theeory results in a number of peculiar properties of the distributions curves in n, that are well confirmed by expe--rimental data. In particular, essential deviations from the KNO scaling are to be observed at very high energy

  12. Multiplicative processes in visual cognition

    Credidio, H. F.; Teixeira, E. N.; Reis, S. D. S.; Moreira, A. A.; Andrade, J. S.

    2014-03-01

    The Central Limit Theorem (CLT) is certainly one of the most important results in the field of statistics. The simple fact that the addition of many random variables can generate the same probability curve, elucidated the underlying process for a broad spectrum of natural systems, ranging from the statistical distribution of human heights to the distribution of measurement errors, to mention a few. An extension of the CLT can be applied to multiplicative processes, where a given measure is the result of the product of many random variables. The statistical signature of these processes is rather ubiquitous, appearing in a diverse range of natural phenomena, including the distributions of incomes, body weights, rainfall, and fragment sizes in a rock crushing process. Here we corroborate results from previous studies which indicate the presence of multiplicative processes in a particular type of visual cognition task, namely, the visual search for hidden objects. Precisely, our results from eye-tracking experiments show that the distribution of fixation times during visual search obeys a log-normal pattern, while the fixational radii of gyration follow a power-law behavior.

  13. Multiple Waveband Temperature Sensor (MWTS)

    Bandara, Sumith V.; Gunapala, Sarath; Wilson, Daniel; Stirbl, Robert; Blea, Anthony; Harding, Gilbert

    2006-01-01

    This slide presentation reviews the development of Multiple Waveband Temperature Sensor (MWTS). The MWTS project will result in a highly stable, monolithically integrated, high resolution infrared detector array sensor that records registered thermal imagery in four infrared wavebands to infer dynamic temperature profiles on a laser-irradiated ground target. An accurate surface temperature measurement of a target in extreme environments in a non-intrusive manner is required. The development challenge is to: determine optimum wavebands (suitable for target temperatures, nature of the targets and environments) to measure accurate target surface temperature independent of the emissivity, integrate simultaneously readable multiband Quantum Well Infrared Photodetectors (QWIPs) in a single monolithic focal plane array (FPA) sensor and to integrate the hardware/software and system calibration for remote temperature measurements. The charge was therefore to develop and demonstrate a multiband infrared imaging camera with the detectors simultaneously sensitive to multiple distinct color bands for front surface temperature measurements Wavelength ( m) measurements. Amongst the requirements are: that the measurement system will not affect target dynamics or response to the laser irradiation and that the simplest criterion for spectral band selection is to choose those practically feasible spectral bands that create the most contrast between the objects or scenes of interest in the expected environmental conditions. There is in the presentation a review of the modeling and simulation of multi-wave infrared temperature measurement and also a review of the detector development and QWIP capacities.

  14. Cognitive Impairment in Multiple Sclerosis

    Farnaz Etesam

    2014-01-01

    Full Text Available Cognitive impairment can emerge in the earliest phases of multiple sclerosis. It strongly impacts different aspects of Multiple Sclerosis (MS patients' lives, like employment, social relationships and the overall quality of life; thus, its on-time recognition and treatment is mandatory. This paper discusses issues, diagnostic methods and treatment options for cognitive dysfunctions in MS. This paper is a descriptive review of the related studies in the recent 10 years, performing a keyword search in the main databases4T. Cognitive impairment mostly involves aspects of information processing, memory and executive functioning in MS. Neuropsychological tests like MACFIMS and BRB-N are recommended for its assessment. Still, there is no fully efficient treatment for cognitive impairment. Researchers have shown some positive effects, using disease-modifying therapies and cognitive rehabilitation. Depression, pain, fatigue and other factors influencing cognitive functions must be paid attention to4T. Recognizing cognitive impairment as a major symptom for MS, makes studying this subject one of the priorities in dealing with the disease. Therefore, a consecutive research for identification and management of this part of quality of life in MS patients is obligatory4T.4T

  15. The diagnosis of multiple sclerosis

    This thesis describes recently developed research methods for the diagnosis of multiple sclerosis. In Chapter X the use of the CT-scan in the detection of hemispheral or cerebellar lesions is discussed. In chapter XIII the results of the application of all methods to a group of 89 patients with definite, probable or possible multiple sclerosis and to a group of 25 purely optic neuritis patients are presented. With the aid of the CT-scan, hypo- or hyperdense areas in the white matter of the cerebral hemispheres were found in 52% of the 114 patients. Most reports ascribe these lesions to demyelinating cerebral plaques. The CT-scan showed no cerebellar or brainstem lesions. The CT-scan is independent of the duration of, and degree of incapacitation due to, the disease and can be helpful in giving a definite diagnosis in an early stage of the disease. The CT-scan will always play an important role for the differential diagnosis. (Auth.)

  16. Is Multiple Sclerosis CNS Leprosy?

    Noha t. Abokrysha

    2008-05-01

    Full Text Available Multiple sclerosis (MS is widely believed to be an autoimmune disorder. Another exciting idea regarding the aetiology of MS may be that the immune response in MS could result from a chronic infection rather than autoimmunity in the usual sense. M. leprae-induced myelin damage in the early infectious process provides valuable insights into the pathologic mechanisms of multiple sclerosis. However, no research has hypothesized the possible involvement of mycobacterium leprae or its components in pathogenesis of MS. Most of the antigens of mycobacterium leprae and mycobacterium tuberculosis are members of stress protein families. Of the M. leprae and M. tuberculosis antigens identified by monoclonal antibodies, all except the 18-kDa M. leprae antigen and the 19-kDa M. tuberculosis antigen are strongly coded with very similar genes. I hypothesize that MS is a syndrome of diseases, induced by intradermal BCG vaccine which may contain the antigen component resembling that of leprae that can either produce central demyelination by itself, or by delayed hypersensitivity. The hypothesis should be assessed in several experimental and clinical trials. If my hypothesis can be verified experimentally and clinically, then measurements to prevent MS disease could be accomplished.

  17. Teaching Multiplication Algorithms from Other Cultures

    Lin, Cheng-Yao

    2007-01-01

    This article describes a number of multiplication algorithms from different cultures around the world: Hindu, Egyptian, Russian, Japanese, and Chinese. Students can learn these algorithms and better understand the operation and properties of multiplication.

  18. Improving Multiple Fault Diagnosability using Possible Conflicts

    National Aeronautics and Space Administration — Multiple fault diagnosis is a difficult problem for dynamic systems. Due to fault masking, compensation, and relative time of fault occurrence, multiple faults can...

  19. Child Abuse - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Child Abuse URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Child Abuse - Multiple Languages To use the sharing features on ...

  20. Dietary Fiber - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Dietary Fiber URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Dietary Fiber - Multiple Languages To use the sharing features on ...

  1. Cosmetic Dentistry - Multiple Languages: MedlinePlus

    ... Here: Home → Multiple Languages → All Health Topics → Cosmetic Dentistry URL of this page: https://www.nlm.nih. ... W XYZ List of All Topics All Cosmetic Dentistry - Multiple Languages To use the sharing features on ...

  2. Postpartum Depression - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Postpartum Depression URL of this page: https://www.nlm.nih. ... V W XYZ List of All Topics All Postpartum Depression - Multiple Languages To use the sharing features on ...

  3. Oil Spills - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Oil Spills URL of this page: https://www.nlm.nih. ... V W XYZ List of All Topics All Oil Spills - Multiple Languages To use the sharing features on ...

  4. Cosmetic Dentistry - Multiple Languages: MedlinePlus

    ... Here: Home → Multiple Languages → All Health Topics → Cosmetic Dentistry URL of this page: https://medlineplus.gov/languages/ ... W XYZ List of All Topics All Cosmetic Dentistry - Multiple Languages To use the sharing features on ...

  5. Parasitic Diseases - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Parasitic Diseases URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Parasitic Diseases - Multiple Languages To use the sharing features on ...

  6. Macular Degeneration - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Macular Degeneration URL of this page: https://www.nlm.nih. ... V W XYZ List of All Topics All Macular Degeneration - Multiple Languages To use the sharing features on ...

  7. Accelerated Cure Project for Multiple Sclerosis

    ... main content Accelerating research toward a cure for multiple sclerosis Home Contact Us Search form Search Connect Volunteer ... is to accelerate efforts toward a cure for multiple sclerosis by rapidly advancing research that determines its causes ...

  8. Postpartum Depression - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Postpartum Depression URL of this page: https://medlineplus.gov/languages/ ... V W XYZ List of All Topics All Postpartum Depression - Multiple Languages To use the sharing features on ...

  9. Mobility Aids - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Mobility Aids URL of this page: https://www.nlm.nih. ... V W XYZ List of All Topics All Mobility Aids - Multiple Languages To use the sharing features on ...

  10. Developing a combinatorial model for the multiple constant multiplication

    Firas Ali Jawad Al-Hasani

    2015-09-01

    Full Text Available A combinatoric model for the multiple constant multiplication (MCM operation is developed. The model is found by decomposing each coefficient using the A−operation into two subexpressions. The constituted subexpressions are, in turn, decomposed using the A−operation. Connecting all of the decompositions results the decomposition graph which represents the solution space. The decomposition graph itself is not feasible for routing to find the minimum solutions. Therefore, a transformation on the A−operation is proposed to make the decomposition graph routable. In this case, the A−operation is transformed into a subexpression operation by replacing the shift information attached to the arcs by the other subexpression information which is called the demand. A demand that attached to an arc will represent its cost. The resulting transformed graph is called the demand graph. The demand graph is augmented with deadheading arcs to make it routable. Deadheading arcs are with zero demand. Similarly, traversing an arc with synthesized demand is of zero cost. Enumerating all of the routes that start from the signal vertex and visit all the coefficients gives all the solutions of the MCM problem. The routing technique requires redirecting the route when encountering an unsynthesized demand. The route in this case backtrack to the first encountered synthesized ancestors for this demand. This routing style analogous to the dynamic capacitated arc routing. To prevent exhaust routing, ant colony optimization (ACO meta-heuristics is proposed to traverse the augmented demand graph. The solution space contains all the possible solutions that can be obtained from using both of the common subexpression elimination (CSE and graph dependent heuristics that traditionally used to solve the MCM operation.

  11. A Robust Two-Phase Pumped Loop With Multiple Evaporators and Multiple Radiators Project

    National Aeronautics and Space Administration — NASA's future spacecraft require advanced thermal management technologies to provide effective cooling for multiple instruments and reject heat through multiple...

  12. Spatial photon correlations in multiple scattering media

    Smolka, Stephan; Muskens, O.; Lagendijk, A.;

    2010-01-01

    We present the first angle-resolved measurements of spatial photon correlations that are induced by multiple scattering of light. The correlation relates multiple scattered photons at different spatial positions and depends on incident photon fluctuations.......We present the first angle-resolved measurements of spatial photon correlations that are induced by multiple scattering of light. The correlation relates multiple scattered photons at different spatial positions and depends on incident photon fluctuations....

  13. Intestinal perforation caused by multiple magnet ingestion

    Nergul Corduk

    2014-01-01

    Full Text Available Multiple magnet ingestion is rare, but can cause serious gastrointestinal complications. We report a case of 7-year-old girl with multiple intestinal perforations caused by multiple magnet ingestion. The aim of this report is to draw attention to magnetic toys, results of magnet ingestion and the importance of timing of operation.

  14. Identifying the Multiple Intelligences of Your Students

    McClellan, Joyce A.; Conti, Gary J.

    2008-01-01

    One way of addressing individual differences among adult learners is to identify the Multiple Intelligences of the learner. Multiple Intelligences refers to the concept developed by Howard Gardner that challenges the traditional view of intelligence and explains the presence of nine different Multiple Intelligences. The purpose of this study was…

  15. Functional Multiple-Set Canonical Correlation Analysis

    Hwang, Heungsun; Jung, Kwanghee; Takane, Yoshio; Woodward, Todd S.

    2012-01-01

    We propose functional multiple-set canonical correlation analysis for exploring associations among multiple sets of functions. The proposed method includes functional canonical correlation analysis as a special case when only two sets of functions are considered. As in classical multiple-set canonical correlation analysis, computationally, the…

  16. Suicide attempts in multiple sclerosis

    Stenager, Elsebeth Nylev; Jensen, Børge; Stenager, Maria;

    2011-01-01

    The purposes of the study were (1) to estimate the risk of suicide attempts in multiple sclerosis (MS) patients in Denmark and compare the risk to the background population in the County of Funen, Denmark; (2) to estimate the risk of suicide attempts in MS patients receiving immunomodulating...... therapy compared with untreated patients. The Danish MS Registry, the Danish MS Treatment Registry and the Suicide Attempt Registry are linked and merged together using a person identification number given to all persons residing in Denmark. Among 404 MS patients, 15 patients had attempted suicide......, although no increased risk for suicide attempts was found in MS patients. No difference in number of suicide attempts in treated and untreated patients was found....

  17. Multiplicative perturbations of local -semigroups

    Chung-Cheng Kuo

    2015-02-01

    In this paper, we establish some left and right multiplicative perturbation theorems concerning local -semigroups when the generator of a perturbed local -semigroup $S(\\cdot)$ may not be densely defined and the perturbation operator is a bounded linear operator from $\\overline{D(A)}$ into () such that = on $\\overline{D(A)}$, which can be applied to obtain some additive perturbation theorems for local -semigroups in which is a bounded linear operator from $[D(A)]$ into () such that = on $\\overline{D(A)}$. We also show that the perturbations of a (local) -semigroup $S(\\cdot)$ are exponentially bounded (resp., norm continuous, locally Lipschitz continuous, or exponentially Lipschitz continuous) if $S(\\cdot)$ is.

  18. Multiplication circuit for particle identification

    After having commented some characteristics of the particles present in a cyclotron, and their interactions, this report addresses the development and the implementation of a method and a device for selecting and counting particles. The author presents the principle and existing techniques of selection. In comparison with an existing device, the proportional counter and the scintillator are replaced by junctions: a surface barrier type junction (a silicon N layer with a very thin oxygen layer playing the role of the P layer), and lithium-based junction (a silicon P type layer made intrinsic by migration of lithium). The author then describes the developed circuit and assembly (background of the choice of a multiplication circuit), and their operation. In the next part, he presents the performed tests and discuses the obtained results. He finally outlines the benefits of the herein presented circuit

  19. [Cognitive Impairment in Multiple Sclerosis].

    Niino, Masaaki; Miyazaki, Yusei

    2016-04-01

    While cognitive impairment is a major symptom of multiple sclerosis (MS), it is commonly overlooked. This may be explained by the fact that it is difficult to evaluate cognitive function in patients with MS using screening batteries for the detection of dementia such as the mini-mental state examination. Further more, cognitive impairment in MS typically involves domain-specific deficits such as imparement of sustained attention and information processing speed rather than global cognitive decline. Cognitive impairment may influence the daily living and social lines of affected patients. This review discusses the characteristics of cognitive impairment, appropreate tests to evaluate its symptoms, and the current status of clinical trials for the treatment of MS. PMID:27056855

  20. Multiple pathways regulate shoot branching

    Catherine eRameau

    2015-01-01

    Full Text Available Shoot branching patterns result from the spatio-temporal regulation of axillary bud outgrowth. Numerous endogenous, developmental and environmental factors are integrated at the bud and plant levels to determine numbers of growing shoots. Multiple pathways that converge to common integrators are most probably involved. We propose several pathways involving not only the classical hormones auxin, cytokinins and strigolactones, but also other signals with a strong influence on shoot branching such as gibberellins, sugars or molecular actors of plant phase transition. We also deal with recent findings about the molecular mechanisms and the pathway involved in the response to shade as an example of an environmental signal controlling branching. We propose the TCP transcription factor TB1/BRC1 and the polar auxin transport stream in the stem as possible integrators of these pathways. We finally discuss how modeling can help to represent this highly dynamic system by articulating knowledges and hypothesis and calculating the phenotype properties they imply.

  1. Autonomic Dysregulation in Multiple Sclerosis.

    Pintér, Alexandra; Cseh, Domonkos; Sárközi, Adrienn; Illigens, Ben M; Siepmann, Timo

    2015-01-01

    Multiple sclerosis (MS) is a chronic, progressive central neurological disease characterized by inflammation and demyelination. In patients with MS, dysregulation of the autonomic nervous system may present with various clinical symptoms including sweating abnormalities, urinary dysfunction, orthostatic dysregulation, gastrointestinal symptoms, and sexual dysfunction. These autonomic disturbances reduce the quality of life of affected patients and constitute a clinical challenge to the physician due to variability of clinical presentation and inconsistent data on diagnosis and treatment. Early diagnosis and initiation of individualized interdisciplinary and multimodal strategies is beneficial in the management of autonomic dysfunction in MS. This review summarizes the current literature on the most prevalent aspects of autonomic dysfunction in MS and provides reference to underlying pathophysiological mechanisms as well as means of diagnosis and treatment. PMID:26213927

  2. [Emerging therapies for multiple sclerosis].

    de Lorenzo-Pinto, Ana; Rodríguez-González, Carmen Guadalupe; Ais-Larisgoitia, Arantza

    2013-01-19

    Multiple sclerosis (MS) is an immune-mediated inflammatory disease of the central nervous system considered the second cause of disability in young adults. The prognosis of MS has improved significantly since the approval of the first interferon β in 1993 but, compared to other diseases, few new therapeutic products have been commercialized in the last years. However, currently, there are more than 600 ongoing clinical trials and new drugs that aim to improve efficacy and a more convenient schedule of administration, will appear shortly on the market. On the other hand, new safety issues will arise as well as a significant economic impact on the health system. The main efficacy and safety results of these drugs are reviewed in this paper. They can be classified into 2 groups: oral (fingolimod, laquinimod, teriflunomide, BG-12 [dimethyl fumarate], oral cladribine, dalfampridine) and monoclonal antibodies (rituximab, ocrelizumab, ofatumumab, daclizumab, alemtuzumab). PMID:22766059

  3. 2014 Multiple Sclerosis Therapeutic Update

    Cree, Bruce A. C.

    2014-01-01

    Rapid advances are occurring in multiple sclerosis disease modifying therapies. Recent therapeutic advances include modifications to improve tolerability of existing products (e.g. interferon beta and glatiramer acetate), development of novel anti-neuroinflammatory medications (e.g. fingolimod, teriflunomide and dimethyl fumarate, daclizumab, alemtuzumab, ocrelizumab) and investigation of treatments in progressive MS (e.g. natalizumab, mastinib, natalizumab, siponimod). The impact of vitamin D supplementation on the disease course in relapsing MS patients is also being studied in several clinical trials. This article reviews the current state of the field with a forward look to the next phase of MS research that could focus on strategies to promote remyelination and provide neuronal protection. PMID:24707333

  4. Clonal Evolution in Multiple Myeloma.

    Fakhri, Bita; Vij, Ravi

    2016-08-01

    Multiple myeloma (MM) is the second most common hematologic malignancy encountered among patients in the United States. The last decade has seen incremental improvements in the survival of patients with MM. These advances are, to a large extent, attributable to the addition of proteasome inhibitors and immunomodulatory drugs to the armamentarium of treatment options. The adoption of these drug classes was the result of an empiric research paradigm. However, with the application of next generation sequencing technologies, we are now starting to unravel the genomic landscape of MM. It is hoped that this will allow us to better disentangle the biology of the disease and allow for identification of new therapeutic targets. In this article, we review what we have learned to date about the mutational profile, clonal architecture, and evolution of the disease, and discuss the potential clinical implications of these findings. PMID:27521309

  5. Personality aspects in multiple sclerosis.

    Diana, R; Grosz, A; Mancini, E

    1985-12-01

    To test the claim that peculiar personality bias is detectable in multiple sclerosis (MS) we used the Szondi test to investigate the psychodynamic aspects of 110 MS patients in comparison with 200 healthy subjects. MS patients appeared to have a greater need for love in a passive form than normal people, rigid defense mechanisms, difficulty in resolving their inner conflicts either by sublimation or by internalization of satisfactory new emotional experiences, feelings of autoaggressiveness, and many symptoms of depression. Some of these aspects correlate with the severity of the disease, others seem to date back to early childhood as peculiar personality patterns. An investigation of childhood events in 110 controls confirmed that MS patients had had many more unhappy experiences in childhood than might commonly be expected. Further, the oft-reported psychiatric troubles preceding MS clinical onset suggest that at least in some MS patients there are specific gaps in personality structure dating back to early phases of their development. PMID:4086262

  6. Scheme Dependence and Multiple Couplings

    Jack, Ian

    2016-01-01

    For theories with multiple couplings the perturbative $\\beta$-functions for scalar, Yukawa couplings are expressible in terms of contributions corresponding to one particle irreducible graphs and also contributions which are one particle reducible depending on the anomalous dimension. Here we discuss redefinitions, or changes of scheme, which preserve this structure. The redefinitions allow for IPR contributions of a specific form, as is necessary to encompass the relation between MS and momentum subtraction renormalisation schemes. Many multiply 1PR terms in the transformed $\\beta$-function are generated but these can all be absorbed into antisymmetric contributions to the anomalous dimensions which are essentially arbitrary and can be discarded. As an illustration the results are applied to the scheme dependence of the anomalous dimension, which determines the $\\beta$-function, for ${\\cal N}=1$ supersymmetric scalar fermion theories in four dimensions up to four loops.

  7. Implicit Memory in Multiple Sclerosis

    G. Latchford

    1993-01-01

    Full Text Available A number of neuropsychological studies have revealed that memory problems are relatively common in patients with multiple sclerosis (MS. It may be useful to compare MS with conditions such as Huntington's disease (HD, which have been referred to as subcortical dementia. A characteristic of these conditions may be an impairment in implicit (unconscious memory, but not in explicit (conscious memory. The present study examined the functioning of explicit and implicit memory in MS. Results showed that implicit memory was not significantly impaired in the MS subjects, and that they were impaired on recall but not recognition. A correlation was found between implicit memory performance and disability status in MS patients. Findings also suggest the possibility of long-term priming of implicit memory in the control subjects. The implications of these results are discussed.

  8. Legitimacy Strategy in Institutional Multiplicities

    Rana, Mohammad Bakhtiar; Marinova, Svetla Trifonova; Sørensen, Olav Jull

    2014-01-01

    This paper focuses on ‘institutional void’ (IV) and ‘civil society’ (CS). Investigating five European MNEs in a fragmented business system by using a multiple-case-study method and a sense-making approach, we explore how IV and CS affect MNEs and how MNEs respond to them in pursuit of legitimacy....... Our study reveals three forms of IV, i.e., system void, value chain void, and void between social need and citizen services, and two broad roles of CS, being an enabler and constrainer that affect MNE operations and survival. We validate four types of legitimacy strategies presented by previous......’ or ‘collaborative engagement’. It further illustrates how, through these two strategic initiatives, MNEs can earn and maintain four levels of legitimacy, i.e., acceptance, image, endorsement, and synergy. The paper contributes to the theory and practice of institutionalism, international management, and strategic...

  9. Oral agents in multiple sclerosis.

    Lorefice, L; Fenu, G; Frau, J; Coghe, G C; Marrosu, M G; Cocco, E

    2015-01-01

    Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system. Disease-modifying drugs licensed for MS treatment have been developed to reduce relapse rates and halt disease progression. The majority of current MS drugs involve regular, parenteral administration, affecting long-term adherence and thus reducing treatment efficacy. Over the last two decades great progress has been made towards developing new MS therapies with different modes of action and biologic effects. In particular, oral drugs have generated much interest because of their convenience and positive impact on medication adherence. Fingolimod was the first launched oral treatment for relapsing-remitting MS; recently, Teriflunomide and Dimethyl fumarate have also been approved as oral disease-modifying agents. In this review, we summarize and discuss the history, pharmacodynamics, efficacy, and safety of oral agents that have been approved or are under development for the selective treatment of MS. PMID:25924620

  10. Conformal Mapping for Multiple Terminals

    Wang, Weimin; Wang, Qiang; Ren, Hao

    2015-01-01

    Conformal mapping is an important mathematical tool in many physical and engineering fields, especially in electrostatics, fluid mechanics, classical mechanics, and transformation optics. However in the existing textbooks and literatures, it is only adopted to solve the problems which have only two terminals. Two terminals with electric potential differences, pressure difference, optical path difference, etc., can be mapped conformally onto a solvable structure, e.g., a rectangle, where the two terminals are mapped onto two opposite edges of the rectangle. Here we show a conformal mapping method for multiple terminals, which is more common in practical applications. Through accurate analysis of the boundary conditions, additional terminals or boundaries are folded in the inner of the mapped rectangle. Then the solution will not be influenced. The method is described in several typical situations and two application examples are detailed. The first example is an electrostatic actuator with three electrodes. A ...

  11. Multiple phonon excitation in nuclei

    The studies of multiphonon excitations in nuclei are reviewed both from the theoretical and experimental points of view. The presence of giant resonances in nuclei is described in the framework of macroscopic and microscopic models and the relative merits of different probes to excite such states are illustrated. The existence of giant resonances built on excited states is stressed. An exhaustive description of the theoretical estimates of the properties of the multiphonon states is presented. The theory predicts that such multiple collective excitations should closely follow a harmonic pattern. Recent experimental results on the double giant dipole resonance using the (π+π-) double charge exchange reaction are shown. The status of the search for isoscalar multiphonon excitations by means of the strong nuclear potential produced by heavy ions is presented. Conclusions are drawn and new prospects are discussed. (authors) 293 refs., 67 figs., 8 tabs

  12. [Vitamin D in Multiple Sclerosis].

    Niino, Masaaki; Miyazaki, Yusei

    2015-11-01

    The geographic epidemiology of multiple sclerosis (MS) suggests that low vitamin D levels are a modifiable risk factor. Previous studies have shown that patients with MS have significantly lower vitamin D levels compared with healthy controls. Vitamin D is a potent immunomodulator important for immune function and development, and it offers potential benefits by reducing inflammation. Vitamin D has beneficial effects in experimental autoimmune encephalomyelitis, an animal model of MS. In summation, these studies suggest that vitamin D may have therapeutic potential for MS. This has not been established although preliminary clinical trials for vitamin D in MS look promising. Genetic studies suggest that genes associated with vitamin D are critical susceptible genes for MS. In this review, we discuss current research investigating the association between vitamin D and MS and the issues that need to be resolved. PMID:26560958

  13. Vitamin D and multiple sclerosis.

    Asghar Amini Harandi

    2014-03-01

    Full Text Available Multiple sclerosis (MS is a chronic demyelinating disease and also is one of the most common disabling neurological disorders in young and middle-aged adults. The main pathogenesis of MS has long been thought to be an immune mediated disorder of the central nervous system. The function of the immune system is under the influence of vitamin D which as a modulator of immune response could play a role in autoimmune diseases including MS. Deficiency of vitamin D or variations in DNA sequence (polymorphism of vitamin D receptor gene diminishes its optimal function on immune system that consequently could lead to increasing risk of MS. However, its role in development and modulating the course of MS is still under investigation. In this review we aimed to discuss the role of vitamin D in body, immune system and consequently altering the risk of MS.

  14. Cognitive dysfunction in Multiple Sclerosis

    JoanaGuimarães

    2012-05-01

    Full Text Available In Multiple Sclerosis (MS prevalence studies of community and clinical samples, indicate that 45–60% of patients are cognitively impaired. These cognitive dysfunctions have been traditionally described as heterogeneous, but more recent studies suggest that there is a specific pattern of MS-related cognitive dysfunctions. With the advent of disease-modifying medications for MS and emphasis on early intervention and treatment, detection of cognitive impairment at its earliest stage becomes particularly important. In this review the authors address: the cognitive domains most commonly impaired in MS (memory, attention, executive functions, speed of information processing and visual spatial abilities; the physiopathological mechanism implied in MS cognitive dysfunction and correlated brain MRI features; the importance of neuropsychological assessment of MS patients in different stages of the disease and the influence of its course on cognitive performance; the most used tests and batteries for neuropsychological assessment; therapeutic strategies to improve cognitive abilities.

  15. Duration judgements over multiple elements

    InciAyhan

    2012-11-01

    Full Text Available We investigated the limits of the number of events observers can simultaneously time. For single targets occurring in one of eight positions sensitivity to duration was improved for spatially pre-cued items as compared to post-cued items indicating that exogenous driven attention can improve duration discrimination. Sensitivity to duration for pre-cued items was also marginally better for single items as compared to eight items indicating that even after the allocation of focal attention, distracter items can interfere with the encoding of duration. For an eight item array discrimination was worse for post-cued locations as compared to pre-cued locations indicating both that attention can improve duration discrimination performance and that it was not possible to access a perfect memory trace of the duration of eight elements. The interference from the distracters in the pre-cued eight item array may reflect some mandatory averaging of target and distracter events. To further explore duration averaging we asked subjects to explicitly compare average durations of multiple item arrays against a single item standard duration. Duration discrimination thresholds were significantly lower for single elements as compared to multiple elements, showing that averaging, either automatically or intentionally, impairs duration discrimination. There was no set size effect. Performance was the same for averages of two and eight items, but performance with even an average of two items was worse than for one item. This was also true for sequential presentation indicating poor performance was not due to limits on the division of attention across items. Rather performance appears to be limited by an inability to remember or aggregate duration information from two or more items. Although it is possible to manipulate perceived duration locally, there appears to be no perceptual mechanisms for aggregating local durations across space.

  16. MRI diagnosis of multiple sclerosis

    Objective: It's a study of MRI diagnosis and differential diagnosis of multiple sclerosis (MS) in 49 cases. Methods: 49 patients were diagnosed as MS of brain or/and spinal cord in the year of 1995 to 2002. All cases had clinical informations, including evoked potential. MR brain scan was done in 49 patients, and spinal cord scan was performed in 10 cases out of 49. Enhanced scan were done in 29 cases. A follow-up examination was done in 17 patients within 30 days after the initial study. Results: Multiple brain lesions, located in peri-ventricular region, semi-elliptical center, cerebellum and brain stem, were revealed in 47 patients, MS plaques were speckle or patchy and the largest one was 2.2 x 5.0 cm. Simple spinal Cord lesions involving at least 2 sections were revealed in 2 patients. Two cases were initially misdiagnosed as encephalitis. Another case was defined as tumor because of the brainstem swelling and enhanced plaques. Optic nerve impairment was found in a case besides the brain lesions. Complicated brain and spinal Cord lesions were shown in 4 cases. Enhanced MRI scan was performed in 29 cases: non-enhanced lesions were revealed in 7 cases and lesions were enhanced in the rest 22. Mottling or plaque enhancement was presented in 20 cases, while ring enhancement was presented in 2. Follow-up study showed the improvement in 17 cases. Conclusion: Brain and spinal cord MS plaques can be demonstrated on MRI, while clinical manifestation is necessary for MRI diagnosis in atypical lesions. Serial study is helpful for differential diagnosis

  17. Charm production in high multiplicity pp events

    Werner, K; Karpenko, Iu; Pierog, T; Sophys, G

    2016-01-01

    Recent experimental studies of the multiplicity dependence of heavy quark (HQ) production in proton-proton collisions at 7 TeV showed a strong non-linear increase of the HQ multiplicity as a function of the charged particle multiplicity. We try to understand this behavior using the EPOS3 approach. Two issues play an important role: multiple scattering, in particular its impact on multiplicity fluctuations, and the collective hydrodynamic expansion. The results are very robust with respect to many details of the modeling, which means that these data contain valuable information about very basic features of the reaction mechanism in proton-proton collisions.

  18. Multiple elliptic gamma functions associated to cones

    Winding, Jacob

    2016-01-01

    We define generalizations of the multiple elliptic gamma functions and the multiple sine functions, associated to good rational cones. We explain how good cones are related to collections of $SL_r(\\mathbb{Z})$-elements and prove that the generalized multiple sine and multiple elliptic gamma functions enjoy infinite product representations and modular properties determined by the cone. This generalizes the modular properties of the elliptic gamma function studied by Felder and Varchenko, and the results about the usual multiple sine and elliptic gamma functions found by Narukawa.

  19. Multiple intelligences: Can they be measured?

    Kirsi Tirri

    2013-12-01

    Full Text Available This paper is about issues relating to the assessment of multiple intelligences. The first section introduces the authors’ work on building measures of multiple intelligences and moral sensitivities. It also provides a conceptual definition of multiple intelligences based on Multiple Intelligences theory by Howard Gardner (1983. The second section discusses the context specificity of intelligences and alternative approaches to measuring multiple intelligences. The third section analyses the validity of self-evaluation instruments and provides a case example of building such an instrument. The paper ends with concluding remarks.

  20. Coulomb pairing resonances in multiple-ring aromatic molecules

    Huber, D L

    2015-01-01

    We present an analysis of the Coulomb pairing resonances observed in photo-double-ionization studies of CnHm aromatic molecules with multiple benzene-like rings. It is applied to naphthalene, anthracene, phenanthrene, pyrene and coronene, all of which have six-member rings, and azulene which is comprised of a five-member and a seven-member ring. There is a high energy resonance at ~ 40 eV that is found in all of the molecules cited and is associated with paired electrons localized on carbon sites on the perimeter of the molecule, each of which having two carbon sites as nearest neighbors. The low energy resonance at 10 eV, which is found only in pyrene and coronene, is attributed to the formation of paired electrons localized on arrays of interior carbon atoms that have the point symmetry of the molecule with each carbon atom having three nearest neighbors. The origin of the anomalous increase in the doubly charged to singly charged parent-ion ratio that is found above the 40 eV resonance in all of the cited ...

  1. Multiple-ligament injured knee

    SUN Lei; NING Zhi-jie; ZHANG Hui; TIAN Min; NING Tin-min

    2006-01-01

    Objective: To explore the clinical characteristic of the multiple-ligament injured knee and evaluate the protocol,technique and outcome of treatment for the multipleligament injured knee.Methods: From October 2001 to March 2005, 9 knees with combined anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) tears in 9 patients were identified with clinical and arthroscopic examinations. Of them, 5 knees were combined with ruptures of posteromedial corner (PMC) and medial collateral ligament (MCL), 4 with disruptions of posterolateral corner ( PLC), 2 with popliteal vascular injuries and 1 with peroneal nerve injuries. Six patients were hospitalized in acute phase of trauma, 2 received repairs of popliteal artery and 4 had repairs of PMC and MCL. Reconstructions of ACL and PCL with autografts under arthroscope were performed in all patients at 4 to 10 weeks after trauma,including reconstruction of PLC with the posterior half of biceps femoris tendon tenodesis in 4 patients and reconstructions of PMC and MCL with femoral fascia in 1 patient.Results: No severe complications occurred at early stage after operation in the 9 patients. All of them were followed up for 10-39 months with an average of 23. 00 months ± 9.46 months. Lysholm score was 70-95 with an average of 85.00 ± 8.29. International Knee Documentation Committee (IKDC) score was from severely abnormal (Grade D) in 9 knees at initial examination to normal (Grade A) in 2 knees, nearly normal (Grade B ) in 6 knees and abnormal in 1 knee at the last follow-up. Of the 9 patients, 7 returned to the same activity level before injury and 2 were under the level.Conclusions: The multiple-ligament injured knee with severe instability is usually combined with other important structure damages. Therefore, careful assessment and treatment of the combined injuries are essential. Reconstructions of ACL and PCL under arthroscope, combined with repairs or reconstructions of the extraarticular ligaments

  2. Evidence for Multiple Rhythmic Skills.

    Adam Tierney

    Full Text Available Rhythms, or patterns in time, play a vital role in both speech and music. Proficiency in a number of rhythm skills has been linked to language ability, suggesting that certain rhythmic processes in music and language rely on overlapping resources. However, a lack of understanding about how rhythm skills relate to each other has impeded progress in understanding how language relies on rhythm processing. In particular, it is unknown whether all rhythm skills are linked together, forming a single broad rhythmic competence, or whether there are multiple dissociable rhythm skills. We hypothesized that beat tapping and rhythm memory/sequencing form two separate clusters of rhythm skills. This hypothesis was tested with a battery of two beat tapping and two rhythm memory tests. Here we show that tapping to a metronome and the ability to adjust to a changing tempo while tapping to a metronome are related skills. The ability to remember rhythms and to drum along to repeating rhythmic sequences are also related. However, we found no relationship between beat tapping skills and rhythm memory skills. Thus, beat tapping and rhythm memory are dissociable rhythmic aptitudes. This discovery may inform future research disambiguating how distinct rhythm competencies track with specific language functions.

  3. Natalizumab therapy of multiple sclerosis.

    Hutchinson, Michael

    2010-10-01

    Multiple sclerosis (MS) is the commonest disabling neurological disease of young and middle-aged adults affecting 1 million persons world wide. The illness begins with a relapsing-remitting MS course in 85%–90% of patients; the other 10%–15% have a primary progressive onset MS. Our current understanding is that MS is an autoimmune disorder with an inflammatory T-cell attack on myelin or some component of the oligodendrocyte--myelin structure. Relapses of disease activity result in plaques of demyelination with destruction of myelin and, to a lesser, extent axons. Lymphocytes within the central nervous system tissue recruit more cells leading to an inflammatory cascade that causes myelin damage, axonal disruption, and neuronal death. If the plaque occurs in a vocal area of the central nervous system then symptoms relating to that area result. However, magnetic resonance imaging shows that approximately 10 times more lesions occur in asymptomatic areas of the brain. Recovery from an initial relapse may appear relatively complete but persistent inflammation results in axonal injury and residual disability results. With time and accumulated lesion load, secondary degeneration of denuded axons results in the phase of secondary progressive MS usually 15-20 years after onset. PMID:20874255

  4. Neuroendocrine Immunoregulation in Multiple Sclerosis

    Nathalie Deckx

    2013-01-01

    Full Text Available Currently, it is generally accepted that multiple sclerosis (MS is a complex multifactorial disease involving genetic and environmental factors affecting the autoreactive immune responses that lead to damage of myelin. In this respect, intrinsic or extrinsic factors such as emotional, psychological, traumatic, or inflammatory stress as well as a variety of other lifestyle interventions can influence the neuroendocrine system. On its turn, it has been demonstrated that the neuroendocrine system has immunomodulatory potential. Moreover, the neuroendocrine and immune systems communicate bidirectionally via shared receptors and shared messenger molecules, variously called hormones, neurotransmitters, or cytokines. Discrepancies at any level can therefore lead to changes in susceptibility and to severity of several autoimmune and inflammatory diseases. Here we provide an overview of the complex system of crosstalk between the neuroendocrine and immune system as well as reported dysfunctions involved in the pathogenesis of autoimmunity, including MS. Finally, possible strategies to intervene with the neuroendocrine-immune system for MS patient management will be discussed. Ultimately, a better understanding of the interactions between the neuroendocrine system and the immune system can open up new therapeutic approaches for the treatment of MS as well as other autoimmune diseases.

  5. Evidence for Multiple Rhythmic Skills.

    Tierney, Adam; Kraus, Nina

    2015-01-01

    Rhythms, or patterns in time, play a vital role in both speech and music. Proficiency in a number of rhythm skills has been linked to language ability, suggesting that certain rhythmic processes in music and language rely on overlapping resources. However, a lack of understanding about how rhythm skills relate to each other has impeded progress in understanding how language relies on rhythm processing. In particular, it is unknown whether all rhythm skills are linked together, forming a single broad rhythmic competence, or whether there are multiple dissociable rhythm skills. We hypothesized that beat tapping and rhythm memory/sequencing form two separate clusters of rhythm skills. This hypothesis was tested with a battery of two beat tapping and two rhythm memory tests. Here we show that tapping to a metronome and the ability to adjust to a changing tempo while tapping to a metronome are related skills. The ability to remember rhythms and to drum along to repeating rhythmic sequences are also related. However, we found no relationship between beat tapping skills and rhythm memory skills. Thus, beat tapping and rhythm memory are dissociable rhythmic aptitudes. This discovery may inform future research disambiguating how distinct rhythm competencies track with specific language functions. PMID:26376489

  6. Electrically actuated multiple store launcher

    Marshall, Frank P.; Travor, Bruce W.

    1991-12-01

    This invention comprises a multi-store, electrical pulse initiated launcher that fits into, and is electrically connected with a transporting vehicle and that contains sequentially stacked assemblies. An electrical pulse from the transporting vehicle causes a resistor with the least value to transfer the electric sufficient gas pressure to force the store out of the launcher. The present invention discloses an electrically-actuated, multi-store dispenser wherein an initial electrical charge ignites gas cartridges causing sequential launching of stores from their tandem position inside a launch container. In some environments, it is desirable to dispense multiple stores from a launch vehicle, for instance sonobuoys, in dense patterns. Due to physical limitations of space in the dispensing vehicle, an effort was made to miniaturize the active components inside the store and therefore reduce the overall outer dimensions thereof. Once the size of the store was reduced, in order to meet the demands of the denser patterns, the inside of the individual launch containers were modified to allow each to hold and dispense more than one store. This new type of launch container, in addition to maintaining the size requirement dictated by the transporting vehicle, is operated by the vehicle's electrical system.

  7. Multiple-measurement beam probe

    Particle accelerators are becoming smaller and are producing more intense beams; therefore, it is critical that beam-diagnostic instrumentation provide accelerator operators and automated control systems with a complete set of beam information. Traditionally, these beam data were collected and processed using limited-bandwidth interceptive techniques. For the new-generation accelerators, we are developing a multiple-measurement microstrip probe to obtain broadband beam data from inside a drift tube without perturbing the beam. The cylindrical probe's dimensions are 6-cm OD by 1.0 m long, and the probe is mounted inside a drift tube. The probe (and its associated electronics) monitors bunched-beam current, energy, and transverse position by sensing the beam's electromagnetic fields through the annular opening in the drift tube. The electrical impedance is tightly controlled through the full length of the probe and transmission lines to maintain beam-induced signal fidelity. The probe's small, cylindrical structure is matched to beam-bunch characteristics at specific beamline locations so that signal-to-noise ratios are optimized. Surrounding the probe, a mechanical structure attaches to the drift-tube interior and the quadrupole magnets; thus, the entire assembly's mechanical and electrical centers can be aligned and calibrated with respect to the rest of the linac

  8. Mechanisms of multiple chemical sensitivity.

    Winder, Chris

    2002-03-10

    Sensitivity to chemicals is a toxicological concept, contained in the dose-response relationship. Sensitivity also includes the concept of hypersensitivity, although controversy surrounds the nature of effects from very low exposures. The term multiple chemical sensitivity has been used to describe individuals with a debilitating, multi-organ sensitivity following chemical exposures. Many aspects of this condition extend the nature of sensitivity to low levels of exposure to chemicals, and is a designation with medical, immunological, neuropsychological and toxicological perspectives. The basis of MCS is still to be identified, although a large number of hypersensitivity, immunological, psychological, neurological and toxicological mechanisms have been suggested, including: allergy; autosuggestion; cacosomia; conditioned response; immunological; impairment of biochemical pathways involved in energy production; impairment of neurochemical pathways; illness belief system; limbic kindling; olfactory threshold sensitivity; panic disorder; psychosomatic condition; malingering; neurogenic inflammation; overload of biotransformation pathways (also linked with free radical production); psychological or psychiatric illness; airway reactivity; sensitisation of the neurological system; time dependent sensitisation, toxicant induced loss of tolerance. Most of these theories tend to break down into concepts involving: (1) disruption in immunological/allergy processes; (2) alteration in nervous system function; (3) changes in biochemical or biotransformation capacity; (4) changes in psychological/neurobehavioural function. Research into the possible mechanisms of MCS is far from complete. However, a number of promising avenues of investigation indicate that the possibility of alteration of the sensitivity of nervous system cells (neurogenic inflammation, limbic kindling, cacosomia, neurogenic switching) are a possible mechanism for MCS. PMID:11869820

  9. Temperature standardization of multiple spirometers.

    Linn, W S; Solomon, J C; Gong, H; Avol, E L; Peters, J M

    1998-02-01

    In respiratory health surveys involving multiple spirometers, spirometer differences may introduce important biases. We investigated temperature measurement variability as a cause of spirometer differences. Digital thermometers recorded internal (cylinder) and external (outer casing) temperatures of six similar rolling-seal spirometers during field use and in laboratory tests at controlled room temperatures. Internal and external thermometers substantially agreed in recording spirometer temperature changes, which lagged room temperature changes. Offsets of individual thermometers from overall mean readings were roughly the same in field testing of 3908 students in > 60 schools over 5 months and in subsequent laboratory tests. Thermometers differed by as much as 1.3 degrees C, causing differences as large as 0.8% in vital capacity measurements. We conclude that (1) interior and exterior temperatures of typical rolling-seal spirometers do not differ greatly, although both may differ from surrounding air temperature; and (2) variations between individual digital thermometers may be large enough to bias spirometric data appreciably in large-scale surveys. Variations should be controlled by selection of similar-reading thermometers and/or correction to a uniform standard. PMID:9503291

  10. Islamic fasting and multiple sclerosis

    2014-01-01

    Background Month-long daytime Ramadan fasting pose s major challenges to multiple sclerosis (MS) patients in Muslim countries. Physicians should have practical knowledge on the implications of fasting on MS. We present a summary of database searches (Cochrane Database of Systematic Reviews, PubMed) and a mini-symposium on Ramadan fasting and MS. In this symposium, we aimed to review the effect of fasting on MS and suggest practical guidelines on management. Discussion In general, fasting is possible for most stable patients. Appropriate amendment of drug regimens, careful monitoring of symptoms, as well as providing patients with available evidence on fasting and MS are important parts of management. Evidence from experimental studies suggests that calorie restriction before disease induction reduces inflammation and subsequent demyelination and attenuates disease severity. Fasting does not appear to have unfavorable effects on disease course in patients with mild disability (Expanded Disability Status Scale (EDSS) score ≤3). Most experts believed that during fasting (especially in summer), some MS symptoms (fatigue, fatigue perception, dizziness, spasticity, cognitive problems, weakness, vision, balance, gait) might worsen but return to normal levels during feasting. There was a general consensus that fasting is not safe for patients: on high doses of anti-convulsants, anti-spastics, and corticosteroids; with coagulopathy or active disease; during attacks; with EDSS score ≥7. Summary These data suggest that MS patients should have tailored care. Fasting in MS patients is a challenge that is directly associated with the spiritual belief of the patient. PMID:24655543

  11. Multiple-dose acetaminophen pharmacokinetics.

    Sahajwalla, C G; Ayres, J W

    1991-09-01

    Four different treatments of acetaminophen (Tylenol) were administered in multiple doses to eight healthy volunteers. Each treatment (325, 650, 825, and 1000 mg) was administered five times at 6-h intervals. Saliva acetaminophen concentration versus time profiles were determined. Noncompartmental pharmacokinetic parameters were calculated and compared to determine whether acetaminophen exhibited linear or dose-dependent pharmacokinetics. For doses less than or equal to 18 mg/kg, area under the curve (AUC), half-life (t1/2), mean residence time (MRT), and ratio of AUC to dose for the first dose were compared with the last dose. No statistically significant differences were observed in dose-corrected AUC for the first or last dose among subjects or treatments. Half-lives and MRT were not significantly different among treatments for the first or the last dose. Statistically significant differences in t1/2 and MRT were noted (p less than 0.05) among subjects for the last dose. A plot of AUC versus dose for the first and the last doses exhibited a linear relationship. Dose-corrected saliva concentration versus time curves for the treatments were superimposable. Thus, acetaminophen exhibits linear pharmacokinetics for doses of 18 mg/kg or less. Plots of AUC versus dose for one subject who received doses higher than 18 mg/kg were curved, suggesting nonlinear behavior of acetaminophen in this subject. PMID:1800709

  12. Multiple sclerosis: Prospects and promise.

    Hauser, Stephen L; Chan, Jonah R; Oksenberg, Jorge R

    2013-09-01

    We have entered a golden era in multiple sclerosis (MS) research. Two decades ago, our understanding of the disease was largely descriptive and there were no approved therapies to modify the natural history of MS. Today, delineation of immune pathways relevant to MS have been clarified; a comprehensive map of genes that influence risk compiled; clues to environmental triggers identified; noninvasive in vivo monitoring of the MS disease process has been revolutionized by high-field MRI; and many effective therapies for the early, relapsing, component of MS now exist. However, major challenges remain. We still have no useful treatment for progressive MS (the holy grail of MS research), no means to repair injured axons or protect neurons, and extremely limited evidence to guide treatment decisions. Recent advances have set in place a foundation for development of increasingly selective immunotherapy for patients; application of genetic and genomic discoveries to improve therapeutic options; development of remyelination or neuroprotection therapies for progressive MS; and integrating clinical, imaging and genomic data for personalized medicine. MS has now advanced from the backwaters of autoimmune disease research to the front-line, and definitive answers, including cures, are now realistic goals for the next decade. Many of the breakthrough discoveries in MS have also resulted from meaningful interactions across disciplines, and especially from translational and basic scientists working closely with clinicians, highlighting that the clinical value of discoveries are most often revealed when ideas developed in the laboratory are tested at the bedside. PMID:23955638

  13. Natalizumab therapy of multiple sclerosis.

    Hutchinson, Michael

    2012-02-01

    Multiple sclerosis (MS) is the commonest disabling neurological disease of young and middle-aged adults affecting 1 million persons world wide. The illness begins with a relapsing-remitting MS course in 85%-90% of patients; the other 10%-15% have a primary progressive onset MS. Our current understanding is that MS is an autoimmune disorder with an inflammatory T-cell attack on myelin or some component of the oligodendrocyte--myelin structure. Relapses of disease activity result in plaques of demyelination with destruction of myelin and, to a lesser, extent axons. Lymphocytes within the central nervous system tissue recruit more cells leading to an inflammatory cascade that causes myelin damage, axonal disruption, and neuronal death. If the plaque occurs in a vocal area of the central nervous system then symptoms relating to that area result. However, magnetic resonance imaging shows that approximately 10 times more lesions occur in asymptomatic areas of the brain. Recovery from an initial relapse may appear relatively complete but persistent inflammation results in axonal injury and residual disability results. With time and accumulated lesion load, secondary degeneration of denuded axons results in the phase of secondary progressive MS usually 15-20 years after onset.

  14. Rehabilitation challenges in multiple sclerosis

    Burks Jack

    2009-01-01

    Full Text Available While current immunomodulating drugs aim to reduce multiple sclerosis (MS exacerbations and slow disease progression, rehabilitation aims to improve and maintain the functional abilities of patients in the face of disease progression. An increasing number of journal articles are describing the value of the many rehabilitation interventions that can be used throughout the course of the disease, from the initial symptoms to the advanced stages. An integrated team of healthcare professionals is necessary to address a myriad of problems to reduce impairments, disabilities, and handicaps. The problems may be related to fatigue, weakness, spasticity, mobility, balance, pain, cognition, mood, relationships, bowel, bladder, sexual function, swallowing, speech, transportation, employment, recreation, and activities of daily living (ADL such as dressing, eating, bathing, and household chores. The team can help prevent complications and secondary disabilities, while increasing patient safety. Improving neurologically related function, maintaining good relationships, and feeling productive and creative adds enormously to the quality of life of people with MS and their families. Rehabilitation is more than an ′extra′ service that is given after medical therapies; it is an integral part of the management of the diverse set of problems encountered throughout the course of the disease. An interdisciplinary team may have many members, including physicians, nurses, physical therapists, occupational therapists, speech and language pathologists, psychotherapists, social workers, recreational therapists, vocational rehabilitation therapists, patients, families, and other caregivers.

  15. Multiple-bandwidth photoacoustic tomography

    Photoacoustic tomography, also referred to as optoacoustic tomography, employs short laser pulses to generate ultrasonic waves in biological tissues. The reconstructed images can be characterized by the convolution of the structure of samples, the laser pulse and the impulse response of the ultrasonic transducer used for detection. Although the laser-induced ultrasonic waves cover a wide spectral range, a single transducer can receive only part of the spectrum because of its limited bandwidth. To systematically analyse this problem, we constructed a photoacoustic tomographic system that uses multiple ultrasonic transducers simultaneously, each at a different central frequency. The photoacoustic images associated with the different transducers were compared and analysed. The system was tested by imaging both mouse brains and phantom samples. The vascular vessels in the brain were revealed by all of the transducers, but the image resolutions differed. The higher frequency detectors provided better image resolution while the lower frequency detectors delineated the major structural traits with a higher signal-noise ratio

  16. Pediatric multiple sclerosis in Venezuela

    Joaquín A. Peña

    2012-04-01

    Full Text Available OBJECTIVE: To describe the epidemiological and clinical characteristics of Venezuelan pediatric patients with multiple sclerosis (MS. METHODS: Database records from the National Program for MS were searched for patients with an established diagnosis of MS whose first symptoms appeared before age 18. RESULTS: The national database held records of 1.710 patients; 3.8% had onset of the first symptoms before age 18. 46.7% were boys, yielding an F:M ratio of 1.13:1. Many children had a disease onset characterized by motor impairment (30.7%, brainstem/cerebellum and spinal cord affectation (27.6%, headache (26%. Less frequent symptoms were sensory symptoms (8% and optic neuritis (7%. DISCUSSION: Pediatric MS patients in Venezuela represent a significant proportion of all MS cases. The clinical pattern is characterized by motor symptoms at onset, and predominantly monosymptomatic presentation with a relapsing-remitting pattern. This is the first systematic attempt to estimate the prevalence of pediatric MS in Venezuela.

  17. Multiple impacts of dusty projectiles

    Kothe, Stefan; Güttler, Carsten; Blum, Jurgen

    In the context of early stages of planetesimal formation we performed laboratory and drop tower experiments to study multiple impacts of small dust-aggregate projectiles into solid sintered dust targets. Both collision partners consisted of 1.5 µm monodisperse spherical SiO2 monomers with volume filling factors of 0.15 (projectiles) and 0.35 (targets), respectively. The fragile projectiles were accelerated by a solenoid accelerator with a linear projectile magazine, which enabled us to perform 25 impacts within 4.5 s of microgravity time in the Bremen drop tower. We measured the mass-accretion efficiency for different impact velocities between 3 and 5 m s-1 , using an analytical balance and imaging methods. Furthermore, we observed random collisions among small dust aggregates with sizes around 1 mm and collision velocities of the order of 0.25 m s-1 and used them to improve the dust-aggregate collision model of Güttler et al. (2010). u

  18. Blind Estimation of Multiple Carrier Frequency Offsets

    Yu, Yuanning; Poor, H Vincent; Koivunen, Visa

    2007-01-01

    Multiple carrier-frequency offsets (CFO) arise in a distributed antenna system, where data are transmitted simultaneously from multiple antennas. In such systems the received signal contains multiple CFOs due to mismatch between the local oscillators of transmitters and receiver. This results in a time-varying rotation of the data constellation, which needs to be compensated for at the receiver before symbol recovery. This paper proposes a new approach for blind CFO estimation and symbol recovery. The received base-band signal is over-sampled, and its polyphase components are used to formulate a virtual Multiple-Input Multiple-Output (MIMO) problem. By applying blind MIMO system estimation techniques, the system response is estimated and used to subsequently transform the multiple CFOs estimation problem into many independent single CFO estimation problems. Furthermore, an initial estimate of the CFO is obtained from the phase of the MIMO system response. The Cramer-Rao Lower bound is also derived, and the la...

  19. Multiple Imputations for LInear Regression Models

    Brownstone, David

    1991-01-01

    Rubin (1987) has proposed multiple imputations as a general method for estimation in the presence of missing data. Rubin’s results only strictly apply to Bayesian models, but Schenker and Welsh (1988) directly prove the consistency  multiple imputations inference~ when there are missing values of the dependent variable in linear regression models. This paper extends and modifies Schenker and Welsh’s theorems to give conditions where multiple imputations yield consistent inferences for bo...

  20. Inventory verification measurements using neutron multiplicity counting

    Ensslin, N.; Foster, L.A.; Harker, W.C.; Krick, M.S.; Langner, D.G.

    1998-12-31

    This paper describes a series of neutron multiplicity measurements of large plutonium samples at the Los Alamos Plutonium Facility. The measurements were corrected for bias caused by neutron energy spectrum shifts and nonuniform multiplication, and are compared with calorimetry/isotopics. The results show that multiplicity counting can increase measurement throughput and yield good verification results for some inventory categories. The authors provide recommendations on the future application of the technique to inventory verification.

  1. Multiple gestation epidemiology--15 years survey

    Rodrigues, CT; Branco, MR; Ferreira, ID; Nordeste, A; Fonseca, M.; Taborda, A.; Santos-Silva, I; Almeida, MC

    2005-01-01

    Between January of 1987 and December of 2001 were born 1243 twins related to 609 multiple pregnancies, in Maternidade Bissaya-Barreto. Data were grouped in periods of three years and several parameters were studied. The rate of multiple gestation has increased probably due to the contribution of the assisted conception techniques, and to the increase of the number of multiple fetal pregnancies (two or more) and to the increase of the mother age. These more frequent obstetric problems were pre...

  2. Multiple Spatial Representations for Haptic Perception

    Tamè, Luigi

    2010-01-01

    In everyday life, our body gets in contact with multiple tactile stimuli from the outside world. How our somatosensory system identifies and localises these multiple stimuli entering in contact with our body surface, is the general framework to which the researches of the present thesis belong. Tactile stimuli on our body can be spatially coded and represented by using multiple reference frames. Touch is initially encoded into a sensory-space within primary somatosensory map and then further ...

  3. An algorithm for multiplication of Dirac numbers

    Aleksandr Cariow; Galina Cariowa

    2013-01-01

    In this work a rationalized algorithm for Dirac numbers multiplication is presented. This algorithm has a low computational complexity feature and is well suited to parallelization of computations. The computation of two Dirac numbers product using the naïve method takes 256 real multiplications and 240 real additions, while the proposed algorithm can compute the same result in only 128 real multiplications and 160 real additions. During synthesis of the discussed algorithm we use the fact th...

  4. Multiple-Valued Logic Concepts and Representations

    Miller, D Michael

    2007-01-01

    Multiple Valued Logic: Concepts and Representations begins with a survey of the use ofmultiple-valued logic in several modern application areas including electronic design automation algorithms and circuit design. The mathematical basis and concepts of various algebras and systems of multiple valued logic are provided including comparisons among various systems and examples of their application. The book also provides an examination of alternative representations of multiple-valued logic suitable for implementation as data structures in automated computer applications. Decision diagram structu

  5. The $j$-Multiplicity of Monomial Ideals

    Jeffries, Jack; Montaño, Jonathan

    2012-01-01

    We prove a characterization of the j-multiplicity of a monomial ideal as the normalized volume of a polytopal complex. Our result is an extension of Teissier's volume-theoretic interpretation of the Hilbert-Samuel multiplicity for m-primary monomial ideals. We also give a description of the epsilon-multiplicity of a monomial ideal in terms of the volume of a region.

  6. Class II HLA antigens in multiple sclerosis.

    Miller, D H; Hornabrook, R W; Dagger, J; Fong, R

    1989-01-01

    HLA typing in Wellington revealed a stronger association of multiple sclerosis with DR2 than with DQw1. The association with DQw1 appeared to be due to linkage disequilibrium of this antigen with DR2. These results, when considered in conjunction with other studies, are most easily explained by the hypothesis that susceptibility to multiple sclerosis is influenced by multiple risk factors, with DR2 being an important risk factor in Caucasoid populations. PMID:2732726

  7. New multiple aperture arrangements for speckle photography

    Angel-Toro, Luciano; Tebaldi, Myrian; Trivi, Marcelo; Bolognini, Néstor

    2000-01-01

    Abstract. We propose a multiple exposure specklegram by using an optical system whose multiple aperture pupil changes between exposures. In particular, we analyze experimentally two arrangements and we show that it is possible to store the required information by employing a minimum number of registers if an adequate selection of the pupil is done. We study the effect of the decorrelation (among the stored speckle pattern) introduced by changing the multiple aperture pupil arrangements betwee...

  8. Studies using multiple vaccinated animals

    The serological responses in vaccinated and multiple vaccinated cattle against non-structural proteins (NSP) of foot-and-mouth disease (FMD) virus were measured using four commercially available assays. Vaccines were concentrated using polyethylene glycol to contain higher antigenic payloads that those routinely used. Animals received up to five doses of polyvalent oil vaccines over six months, administered by the intra-muscular route on d 0, 90, 130, 160 and 200. Serum samples were taken 30-40 d after each vaccination. At 60 d post vaccination the antibody response to each of the vaccine strains showed high levels of antibodies against structural proteins that correlated with protection against challenge above 81%. The detection of antibodies against NSP was made with two ELISAs using expressed 3ABC as antigen; one ELISA using peptides from 3B and an enzyme-immunotransfer blot assay (EITB). Locally produced ELISA-3ABC reagents and agar gel immunodiffusion using VIAA, were also evaluated. After four doses of vaccine, animals were negative in all the assays. After the fifth immunization, two of seventeen animals were reactive in one ELISA kit, but these samples proved negative by confirmatory tests. Antibodies against NSP were not detected in primo-vaccinated cattle used for potency tests using three batches of standard vaccine. The principle of the NSP ELISA as screening test for large sero surveys in South America is established and this paper emphasises the importance using vaccines that have no demonstrated interference with NSP ELISAs and the advantages of reducing the number of false-positives that would require further confirmation by other assays. (author)

  9. Taste dysfunction in multiple sclerosis.

    Doty, Richard L; Tourbier, Isabelle A; Pham, Dzung L; Cuzzocreo, Jennifer L; Udupa, Jayaram K; Karacali, Bilge; Beals, Evan; Fabius, Laura; Leon-Sarmiento, Fidias E; Moonis, Gul; Kim, Taehoon; Mihama, Toru; Geckle, Rena J; Yousem, David M

    2016-04-01

    Empirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 % for caffeine, 21.9 % for citric acid, 24.66 % for sucrose, and 31.50 % for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain. PMID:26810729

  10. Nutrition facts in multiple sclerosis.

    Riccio, Paolo; Rossano, Rocco

    2015-01-01

    The question whether dietary habits and lifestyle have influence on the course of multiple sclerosis (MS) is still a matter of debate, and at present, MS therapy is not associated with any information on diet and lifestyle. Here we show that dietary factors and lifestyle may exacerbate or ameliorate MS symptoms by modulating the inflammatory status of the disease both in relapsing-remitting MS and in primary-progressive MS. This is achieved by controlling both the metabolic and inflammatory pathways in the human cell and the composition of commensal gut microbiota. What increases inflammation are hypercaloric Western-style diets, characterized by high salt, animal fat, red meat, sugar-sweetened drinks, fried food, low fiber, and lack of physical exercise. The persistence of this type of diet upregulates the metabolism of human cells toward biosynthetic pathways including those of proinflammatory molecules and also leads to a dysbiotic gut microbiota, alteration of intestinal immunity, and low-grade systemic inflammation. Conversely, exercise and low-calorie diets based on the assumption of vegetables, fruit, legumes, fish, prebiotics, and probiotics act on nuclear receptors and enzymes that upregulate oxidative metabolism, downregulate the synthesis of proinflammatory molecules, and restore or maintain a healthy symbiotic gut microbiota. Now that we know the molecular mechanisms by which dietary factors and exercise affect the inflammatory status in MS, we can expect that a nutritional intervention with anti-inflammatory food and dietary supplements can alleviate possible side effects of immune-modulatory drugs and the symptoms of chronic fatigue syndrome and thus favor patient wellness. PMID:25694551

  11. Knowledge repositories for multiple uses

    Williamson, Keith; Riddle, Patricia

    1991-01-01

    In the life cycle of a complex physical device or part, for example, the docking bay door of the Space Station, there are many uses for knowledge about the device or part. The same piece of knowledge might serve several uses. Given the quantity and complexity of the knowledge that must be stored, it is critical to maintain the knowledge in one repository, in one form. At the same time, because of quantity and complexity of knowledge that must be used in life cycle applications such as cost estimation, re-design, and diagnosis, it is critical to automate such knowledge uses. For each specific use, a knowledge base must be available and must be in a from that promotes the efficient performance of that knowledge base. However, without a single source knowledge repository, the cost of maintaining consistent knowledge between multiple knowledge bases increases dramatically; as facts and descriptions change, they must be updated in each individual knowledge base. A use-neutral representation of a hydraulic system for the F-111 aircraft was developed. The ability to derive portions of four different knowledge bases is demonstrated from this use-neutral representation: one knowledge base is for re-design of the device using a model-based reasoning problem solver; two knowledge bases, at different levels of abstraction, are for diagnosis using a model-based reasoning solver; and one knowledge base is for diagnosis using an associational reasoning problem solver. It was shown how updates issued against the single source use-neutral knowledge repository can be propagated to the underlying knowledge bases.

  12. Multiple endocrine neoplasia type 1

    Luzi Ettore

    2006-10-01

    Full Text Available Abstract Multiple Endocrine Neoplasia type 1 (MEN1 is a rare autosomal dominant hereditary cancer syndrome presented mostly by tumours of the parathyroids, endocrine pancreas and anterior pituitary, and characterised by a very high penetrance and an equal sex distribution. It occurs in approximately one in 30,000 individuals. Two different forms, sporadic and familial, have been described. The sporadic form presents with two of the three principal MEN1-related endocrine tumours (parathyroid adenomas, entero-pancreatic tumours and pituitary tumours within a single patient, while the familial form consists of a MEN1 case with at least one first degree relative showing one of the endocrine characterising tumours. Other endocrine and non-endocrine lesions, such as adrenal cortical tumours, carcinoids of the bronchi, gastrointestinal tract and thymus, lipomas, angiofibromas, collagenomas have been described. The responsible gene, MEN1, maps on chromosome 11q13 and encodes a 610 aminoacid nuclear protein, menin, with no sequence homology to other known human proteins. MEN1 syndrome is caused by inactivating mutations of the MEN1 tumour suppressor gene. This gene is probably involved in the regulation of several cell functions such as DNA replication and repair and transcriptional machinery. The combination of clinical and genetic investigations, together with the improving of molecular genetics knowledge of the syndrome, helps in the clinical management of patients. Treatment consists of surgery and/or drug therapy, often in association with radiotherapy or chemotherapy. Currently, DNA testing allows the early identification of germline mutations in asymptomatic gene carriers, to whom routine surveillance (regular biochemical and/or radiological screenings to detect the development of MEN1-associated tumours and lesions is recommended.

  13. Iron chelation and multiple sclerosis

    Kelsey J. Weigel

    2014-01-01

    Full Text Available Histochemical and MRI studies have demonstrated that MS (multiple sclerosis patients have abnormal deposition of iron in both gray and white matter structures. Data is emerging indicating that this iron could partake in pathogenesis by various mechanisms, e.g., promoting the production of reactive oxygen species and enhancing the production of proinflammatory cytokines. Iron chelation therapy could be a viable strategy to block iron-related pathological events or it can confer cellular protection by stabilizing hypoxia inducible factor 1α, a transcription factor that normally responds to hypoxic conditions. Iron chelation has been shown to protect against disease progression and/or limit iron accumulation in some neurological disorders or their experimental models. Data from studies that administered a chelator to animals with experimental autoimmune encephalomyelitis, a model of MS, support the rationale for examining this treatment approach in MS. Preliminary clinical studies have been performed in MS patients using deferoxamine. Although some side effects were observed, the large majority of patients were able to tolerate the arduous administration regimen, i.e., 6–8 h of subcutaneous infusion, and all side effects resolved upon discontinuation of treatment. Importantly, these preliminary studies did not identify a disqualifying event for this experimental approach. More recently developed chelators, deferasirox and deferiprone, are more desirable for possible use in MS given their oral administration, and importantly, deferiprone can cross the blood–brain barrier. However, experiences from other conditions indicate that the potential for adverse events during chelation therapy necessitates close patient monitoring and a carefully considered administration regimen.

  14. Hearing disorders in multiple sclerosis.

    Furst, Miriam; Levine, Robert A

    2015-01-01

    Multiple sclerosis (MS) is a disease that is both a focal inflammatory and a chronic neurodegenerative disease. The focal inflammatory component is characterized by destruction of central nervous system myelin, including the spinal cord; as such it can impair any central neural system, including the auditory system. While on the one hand auditory complaints in MS patients are rare compared to other senses, such as vision and proprioception, on the other hand auditory tests of precise neural timing are never "silent." Whenever focal MS lesions are detected involving the pontine auditory pathway, auditory tests requiring precise neural timing are always abnormal, while auditory functions not requiring such precise timing are often normal. Azimuth sound localization is accomplished by comparing the timing and loudness of the sound at the two ears. Hence tests of azimuth sound localization must obligatorily involve the central nervous system and particularly the brainstem. Whenever a focal lesion was localized to the pontine auditory pathway, timing tests were always abnormal, but loudness tests were not. Moreover, a timing test that included only high-frequency sounds was very often abnormal, even when there was no detectable focal MS lesion involving the pontine auditory pathway. This test may be a marker for the chronic neurodegenerative aspect of MS, and, as such could be used to complement the magnetic resonance imaging scan in monitoring the neurodegenerative aspect of MS. Studies of MS brainstem lesion location and auditory function have led to advances in understanding how the human brain processes sound. The brain processes binaural sounds independently for time and level in a two-stage process. The first stage is at the level of the superior olivary complex (SOC) and the second at a level rostral to the SOC. PMID:25726295

  15. Multiple scattering in optical coherence microscopy.

    Yadlowsky, M J; Schmitt, J M; Bonner, R F

    1995-09-01

    We show that the multiple-scatter rejection provided by optical coherence microscopy (low-coherence interferometry) can be incomplete in optically turbid media and that multiple scattering manifests itself in two distinct ways. Multiple small-angle scattering results in an effective probe field that is stronger than expected from a first-order beam extinction model, but that contains a distorted wave front that enhances the apparent reflectance of small structures relative to those that are larger than the unscattered incident beam. Multiple wide-angle scattering produces a broad diffuse haze that reduces the contrast of subsequent features. PMID:21060400

  16. Comparing three feedback internal multiple elimination methods

    Song, Jiawen; Verschuur, Eric; Chen, Xiaohong

    2013-08-01

    Multiple reflections have posed a great challenge for current seismic imaging and inversion methods. Compared to surface multiples, internal multiples are more difficult to remove due to poorer move-out discrimination with primaries and we are left with wave equation-based prediction and subtraction methods. In this paper, we focus on the comparison of three data-driven internal multiple elimination (IME) methods based on the feedback model, where two are well established prediction-and-subtraction methods using back-propagated data and surface data, referred to as CFP-based method and surface-based method, respectively, and the third one, an inversion-based method, has been recently extended from estimation of primaries by sparse inversion (EPSI). All these three methods are based on the separation of events from above and below a certain level, after which internal multiples are predicted by convolutions and correlations. We begin with theory review of layer-related feedback IME methods, where implementation steps for each method are discussed, and involved event separation are further analyzed. Then, recursive application of the three IME methods is demonstrated on synthetic data and field data. It shows that the two well established prediction-and-subtraction methods provide similar primary estimation results, with most of the internal multiples being removed while multiple leakage and primary distortion have been observed where primaries and internal multiples interfere. In contrast, generalized EPSI provides reduced multiple leakage and better primary restoration which is of great value for current seismic amplitude-preserved processing. As a main conclusion, with adaptive subtraction avoided, the inversion-based method is more effective than the prediction-and-subtraction methods for internal multiple elimination when primaries and internal multiples overlap. However, the inversion-based method is quite computationally intensive, and more researches on

  17. Modeling Multiple Causes of Carcinogenesis

    Jones, T.D.

    1999-01-24

    multiple causes of carcinogenesis and shifts the risk-assessment logic to considerations of �what dose does?� in contrast to the current process of the substance-specific question of �what dose is?� Whether reactive oxygen is the proximate or contributing cause of disease or simply a better estimate of biologically effective dose, it has enormous advantages for improved risk- and policy-based decisions. Various estimates of immune system modulation will be given based on radiobiology.

  18. Multiple scenarios of bentonite alteration

    Performance assessment for TRU waste repositories has shown that soluble and poorly sorbing nuclides such as I-129 and C-14 dominate the dose. These nuclides are expected to migrate with groundwater flow, hence hydraulic conditions and their evolution with time in the repository are key issues for repository safety. Cementitious material will be used for waste packaging, backfilling and structural material in a TRU waste repository. Bentonite is also expected to be used for some TRU wastes to provide the function of a hydraulic barrier in the disposal system. There is concern that the coexistence of cementitious material and bentonite cause the alteration of smectite due to interaction with hyperalkaline leachates and consequent deleterious perturbation of the function of bentonite as a hydraulic barrier. Many research studies have been performed to identify possible mechanisms of cement-bentonite interaction. However, uncertainties still exist in our understanding of the precise chemical scheme of bentonite alteration in highly alkaline conditions, especially the space and time variation of secondary mineral occurrences. In order to reflect this uncertainty, multiple scenarios of bentonite alteration were developed based on the possible mineralogical changes derived from knowledge of both experiments and observation of natural systems. It was focused that the mineral reaction involving hyperalkaline fluids would thermodynamically depend on the variable chemical condition in bentonite buffer and that kinetics would be important as well as thermodynamic stability in controlling their occurrence, i.e., the kinetic controls may operate to remain metastable minerals over the long term. The mineralogical consequences of the interaction between clays and alkaline fluids are summarized as follows. Clay → C-S-H gel and other solids which can rapidly precipitate. Clay and gel → illite. Clay and gel → metastable zeolite. Clay and gel → metastable zeolite → stable

  19. Modeling Multiple Causes of Carcinogenesis

    Jones, T D

    1999-01-24

    multiple causes of carcinogenesis and shifts the risk-assessment logic to considerations of "what dose does?" in contrast to the current process of the substance-specific question of "what dose is?" Whether reactive oxygen is the proximate or contributing cause of disease or simply a better estimate of biologically effective dose, it has enormous advantages for improved risk- and policy-based decisions. Various estimates of immune system modulation will be given based on radiobiology.

  20. Osteogenic Inhibition in Multiple Myeloma

    Nasim Kalantari

    2013-01-01

    Full Text Available Objective: Multiple myeloma (MM is a plasma cell malignancy where plasma cells are increased in the bone marrow (BM and usually do not enter peripheral blood, but produce harmful factors creating problems in these patients (e.g. malignant plasma cells over activate osteoclasts and inhibit osteoblasts with factors like RANKL and DKK. These factors are a main cause of bone lesion in MM patients. Recently SOST gene which responsible to encodes the sclerostin protein was identify. This protein specifically inhibits Wnt signaling in osteoblasts (inhibition of osteoblast differentiation and proliferation and decrease bone formation and can also cause bone lesion in MM patients.Materials and Methods: In this experimental study, human myeloma cell lines (U266 b1 were purchased from Pasteur Institute of Iran. Samples consisted of BM aspirates from the iliac crest of MM patients. BM with more than 70% plasma cell were selected for our study (6 patients and one healthy donor. RNA extraction was done with Qiagen kit. was undertaken on mRNA of samples and cell lines. Also we purchased unrestricted somatic stem cells from Bonyakhte Company to evaluate the effect of soluble factors from myeloma cell lines on osteogenic differentiation medium.Results: Our results showed that SOST is expressed significantly in primary myeloma cells derived from MM patients and myeloma cell lines. In other words, patients with more bone problems, express SOST in their plasma cells at a higher level. In addition, myeloma cells inhibit osteoblast differentiation in progenitor cells from umbilical cord blood stem cell (UCSC in osteogenic inducing medium.Conclusion: There are many osteoblast maturation inhibitory factors such as DKK, Sfrp and Sclerostin that inhibit maturation of osteoblast in bone. Among osteoblast inhibitory agents (DKK, Sfrp, Sclerostin sclerostin has the highest specificity and therefore will have less side effect versus non-specific inhibitory agents. Our

  1. Testing Programming Skills with Multiple Choice Questions

    Clark, David

    2004-01-01

    Multiple choice questions are a convenient and popular means of testing beginning students in programming courses. However, they are qualitatively different from exam questions. This paper reports on a study into which types of multiple choice programming questions discriminate well on a final exam, and how well they predict exam scores.

  2. Simultaneous Assembly of Multiple Test Forms

    Linden, van der Wim J.; Adema, Jos J.

    1998-01-01

    An algorithm for the assembly of multiple test forms is proposed in which the multiple-form problem is reduced to a series of computationally less intensive two-form problems. At each step, one form is assembled to its true specifications; the other form is a dummy assembled only to maintain a balan

  3. Lung Cancer - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Lung Cancer URL of this page: https://medlineplus.gov/languages/lungcancer.html Other topics ... V W XYZ List of All Topics All Lung Cancer - Multiple Languages ... To use the sharing features on this page, please enable JavaScript. Arabic (العربية) Bosnian (Bosanski) Chinese - ...

  4. Floods - Multiple Languages: MedlinePlus

    ... Are Here: Home → Multiple Languages → All Health Topics → Floods URL of this page: https://medlineplus.gov/languages/floods.html Other topics A-Z A B C ... V W XYZ List of All Topics All Floods - Multiple Languages To use the sharing features on ...

  5. On multiple agent models of moral hazard

    Andrea Attar; Eloisa Campioni; Gwena�l Piaser; Uday Rajan

    2006-01-01

    In multiple principal, multiple agent models of moral hazard, we provide conditions under which the outcomes of equilibria in direct mechanisms are preserved when principals can offer indirect communication schemes. We discuss the role of random allocations and recommendations and relate the result to the existing literature.

  6. MULTIPLE IONIZATION OF ATOMS THROUGH MULTIPHOTON ABSORPTION

    L'Huillier, A

    1987-01-01

    We review the main aspects of multiple ionization of rare gases in strong laser fields (above 1012W.cm-2). We discuss the mechanisms responsible for the multi-electron ejection : inner-shell ionization or outer-shell ionization, one-step or multi-step. We show the differences between one-photon and multi-photon multiple ionization.

  7. Multiple-Access Quantum-Classical Networks

    Razavi, Mohsen

    2011-10-01

    A multi-user network that supports both classical and quantum communication is proposed. By relying on optical code-division multiple access techniques, this system offers simultaneous key exchange between multiple pairs of network users. A lower bound on the secure key generation rate will be derived for decoy-state quantum key distribution protocols.

  8. Students' Reasoning with Reversible Multiplicative Relationships

    Hackenberg, Amy J.

    2010-01-01

    In an 8-month teaching experiment, I investigated how 4 sixth-grade students reasoned with reversible multiplicative relationships. One type of problem involved a known quantity that was a whole number multiple of an unknown quantity, and students were asked to determine the value of the unknown quantity. To solve these problems, students needed…

  9. Distributed video coding with multiple side information

    Huang, Xin; Brites, C.; Ascenso, J.; Pereira, F.; Forchhammer, Søren

    quality of the predictions had a major impact in predictive video coding. In this paper, a DVC solution exploiting multiple side information is proposed; the multiple side information is generated by frame interpolation and frame extrapolation targeting to improve the side information of a single...

  10. Corticosteroids for fat embolism after multiple fractures

    CHEN Huai-sheng; ZHANG Qing-mei; WEN Jun-min; WEN Shun-kang; YI Jing; ZHOU Zhi-qiang; WU Sheng-nan

    2007-01-01

    @@ Fat embolism is a common complication of multiple fractures. Corticosteroids are usually prescribed in prophylactic and treatment of fat embolism. A case of fat embolism followed multiple fractures was hospitalized, and we searched best evidences about corticosteroids for fat embolism so as to provide best therapeutics for the patient.

  11. Multiple scattering Model in GEANT4

    Urbàn, L

    2002-01-01

    We present a new multiple scattering (MSC) model to simulate the multiple scattering of charged particles in matter. This model does not use the Moliere formalism, it is based on the more complete Lewis theory. The model simulates the scattering of the particle after a given step, computes the path length correction and the lateral displacement as well.

  12. Equity Valuation with the Use of Multiples

    Stauropoulos Antonios

    2012-01-01

    Full Text Available Problem statement: Equity valuation with the use of multiples is widely used by academics and practitioners concerning its functionality. This study aims to explore the sensitivity of three multiples in terms of bias. Approach: The three multiples under consideration are the Price-To-Sales (P/S multiple, the Price-To-Book value of equity (P/B multiple and the Price-To-Earnings (P/E multiple using both current and one-year-ahead earnings forecasts. Results: According to the empirical results, the multiples P/mdfy1 and P/mnfy1 are considered to be biased, with their means being negatively biased and their medians being positively biased. The results can be considered as reliable owing to the large sample and the procedure followed for its selection. Conclusion: This study offers a better understanding of the valuation approach through the use of multiples, in order analysts assumption to be more carefully and properly chosen and their results to be more accurately produced.

  13. Reproduction and the risk of multiple sclerosis

    Magyari, Melinda; Koch-Henriksen, Nils Iørgen; Pfleger, Claudia Christina;

    2013-01-01

    The incidence of multiple sclerosis (MS) in Denmark has doubled in women since 1970, whereas it has been almost unchanged in men.......The incidence of multiple sclerosis (MS) in Denmark has doubled in women since 1970, whereas it has been almost unchanged in men....

  14. New management algorithms in multiple sclerosis

    Sorensen, Per Soelberg

    2014-01-01

    complex. The purpose of the review has been to work out new management algorithms for treatment of relapsing-remitting multiple sclerosis including new oral therapies and therapeutic monoclonal antibodies. RECENT FINDINGS: Recent large placebo-controlled trials in relapsing-remitting multiple sclerosis...

  15. 7 CFR 1437.13 - Multiple benefits.

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Multiple benefits. 1437.13 Section 1437.13... General Provisions § 1437.13 Multiple benefits. (a) If a producer is eligible to receive payments under this part and benefits under any other program administered by the Secretary for the same crop...

  16. 7 CFR 783.8 - Multiple benefits.

    2010-01-01

    ... loans or payments resulting from purchase of the additional coverage insurance, as defined in 7 CFR 400... 7 Agriculture 7 2010-01-01 2010-01-01 false Multiple benefits. 783.8 Section 783.8 Agriculture... SPECIAL PROGRAMS TREE ASSISTANCE PROGRAM § 783.8 Multiple benefits. Persons may not receive or...

  17. Managing Multiple Goals in Real Learning Contexts

    Mansfield, Caroline F.

    2009-01-01

    Understanding students' multiple goals in real learning contexts is an emerging area of importance for educators and researchers investigating student motivation in classrooms. This qualitative study conducted over an academic year investigates the multiple goals articulated by seven 11-year-old students and explores relationships between goals…

  18. Food Allergy - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Food Allergy URL of this page: https://medlineplus.gov/ ... V W XYZ List of All Topics All Food Allergy - Multiple Languages To use the sharing features on this page, ...

  19. Schooling Built on the Multiple Intelligences

    Kunkel, Christine D.

    2009-01-01

    This article features a school built on multiple intelligences. As the first multiple intelligences school in the world, the Key Learning Community shapes its students' days to include significant time in the musical, spatial and bodily-kinesthetic intelligences, as well as the more traditional areas of logical-mathematical and linguistics. In…

  20. Multiple Intelligences of Students at Jordanian Universities

    Khataybeh, Abdalla; Al-Sheikh, Kholoud

    2011-01-01

    The present study aimed at investigating different intelligence types among Jordanian students at different public and private universities in Jordan. To achieve such aim, it sought to identify and rank multiple intelligences that characterize students at Jordanian universities, and to identify and rank the differences in multiple intelligences…

  1. Early Complementopathy after Multiple Injuries in Humans

    Burk, Anne-Maud; Martin, Myriam; Flierl, Michael A; Rittirsch, Daniel; Helm, Matthias; Lampl, Lorenz; Bruckner, Uwe; Stahl, Gregory L.; Blom, Anna M.; Perl, Mario; Gebhard, Florian; Huber-Lang, Markus

    2012-01-01

    After severe tissue injury, innate immunity mounts a robust systemic inflammatory response. However, little is known about the immediate impact of multiple trauma on early complement function in humans. In the present study we hypothesized that multiple trauma results in immediate activation, consumption and dysfunction of the complement cascade and that the resulting severe “complementopathy” may be associated with morbidity and mortality.

  2. Genetic variants and multiple myeloma risk

    Martino, Alessandro; Campa, Daniele; Jurczyszyn, Artur;

    2014-01-01

    BACKGROUND: Genetic background plays a role in multiple myeloma susceptibility. Several single-nucleotide polymorphisms (SNP) associated with genetic susceptibility to multiple myeloma were identified in the last years, but only a few of them were validated in independent studies. METHODS: With t...

  3. Demyelination of subcortical nuclei in multiple sclerosis

    Krutenkova, E.; Aitmagambetova, G.; Khodanovich, M.; Bowen, J.; Gangadharan, B.; Henson, L.; Mayadev, A.; Repovic, P.; Qian, P.; Yarnykh, V.

    2016-02-01

    Myelin containing in basal ganglia in multiple sclerosis patients was evaluated using new noninvasive quantitative MRI method fast whole brain macromolecular proton fraction mapping. Myelin level in globus pallidus and putamen significantly decreased in multiple sclerosis patients as compared with healthy control subjects but not in substantia nigra and caudate nucleus.

  4. Multiple Intelligence Theory and English Study

    Wu Xiao ping

    2012-01-01

      The theory of multiple inteligences was developed by Dr. Howard Gardner, proposing eight differentinteligences. These theory had alreadywon the attention to oureducated and produced increasinglyextensive and profound effect. This paper has proved the importanceof multiple intel igencetheory in Englishstudy .

  5. Autoimmune Pancreatitis Exhibiting Multiple Mass Lesions

    Shiokawa, Masahiro; Kodama, Yuzo; Hiramatsu, Yukiko; Kurita, Akira; Sawai, Yugo; Uza, Norimitsu; Watanabe, Tomohiro; Chiba, Tsutomu

    2011-01-01

    Our case is a first report of autoimmune pancreatitis with multiple masses within the pancreas which was pathologically diagnosed by endoscopic ultrasound-guided fine needle aspiration and treated by steroid. The masses disappeared by steroid therapy. Our case is informative to know that autoimmune pancreatitis sometimes exhibits multiple masses within the pancreas and to diagnose it without unnecessary surgery.

  6. Autoimmune pancreatitis exhibiting multiple mass lesions.

    Shiokawa, Masahiro; Kodama, Yuzo; Hiramatsu, Yukiko; Kurita, Akira; Sawai, Yugo; Uza, Norimitsu; Watanabe, Tomohiro; Chiba, Tsutomu

    2011-01-01

    Our case is a first report of autoimmune pancreatitis with multiple masses within the pancreas which was pathologically diagnosed by endoscopic ultrasound-guided fine needle aspiration and treated by steroid. The masses disappeared by steroid therapy. Our case is informative to know that autoimmune pancreatitis sometimes exhibits multiple masses within the pancreas and to diagnose it without unnecessary surgery.

  7. Genetics Home Reference: multiple epiphyseal dysplasia

    ... on PubMed (1 link) PubMed OMIM (6 links) COLLAGEN, TYPE IX, ALPHA-1 EPIPHYSEAL DYSPLASIA, MULTIPLE, 1 EPIPHYSEAL ... Dijkstra I, Verrips A, Taylor JA, Briggs MD. Type IX collagen gene mutations can result in multiple epiphyseal dysplasia ...

  8. Hypermnesia: the role of multiple retrieval cues.

    Otani, H; Widner, R L; Whiteman, H L; St Louis, J P

    1999-09-01

    We demonstrate that encoding multiple cues enhances hypermnesia. College students were presented with 36 (Experiment 1) or 60 (Experiments 2 and 3) sets of words and were asked to encode the sets under single- or multiple-cue conditions. In the single-cue conditions, each set consisted of a cue and a target. In the multiple-cue conditions, each set consisted of three cues and a target. Following the presentation of the word sets, the participants received either three cued recall tests (Experiments 1 and 2) or three free recall tests (Experiment 3). With this manipulation, we observed greater hypermnesia in the multiple-cue conditions than in the single-cue conditions. Furthermore, the greater hypermnesic recall resulted from increased reminiscence rather than reduced intertest forgetting. The present findings support the hypothesis that the availability of multiple retrieval cues plays an important role in hypermnesia. PMID:10540821

  9. Threshold Decryption Scheme with Multiple Policies

    FEI Ru-chun; WANG Li-na

    2005-01-01

    Based on the difficulty in computing discrete logarithm and square root on some special conditions, we propose a basic threshold secret sharing scheme for multiple secrets with multiple policies, which allows a group of users to share multiple secret keys and only one secret shadow to be kept by each user. An efficient threshold decryption scheme with multiple policies is designed on the basis of the basic threshold scheme. This decryption scheme allows multiple secret keys to be shared among a group of users, and each user to keep only one secret shadow. Different public keys can be used to encrypt documents. If and only if the number of cooperated users who keep the secret shadows is greater than or equal to the threshold value of the corresponding secret key,they can cooperate to decrypt the documents. It is proved that the proposed scheme has very strong security, unless the attackers can solve the discrete logarithm problem and the square root problem.

  10. Multiple mediastinal hydatid cysts: a case report.

    Rahimi-Rad, Mohammad Hossein; Mahmodlou, Rahim

    2009-01-01

    Hydatid cyst (HC) in mediastinum is very rare. To the best of our knowledge, a case with multiple HCs in mediastinum is not reported already. We herein report a case of multiple HCs of the mediastinum and liver in a - 50 year-old woman presented with chest pain, cough and dyspnea for about two years. She had been treated for tuberculosis for 20 years. Chest CT scan showed multiple cysts in posterior mediastinum and one cyst in left lobe of liver. Via right posterolateral thoracotomy, multiple cysts were excised in mediastinum. And then, hepatic left lobe cyst was removed trans-diaphragmatically. Histopathologic examination confirmed HCs. Despite its rarity, primary HCs should be considered in the differential diagnosis of mediastinal multiple cystic lesions in endemic regions. PMID:20067057

  11. Demyelination versus remyelination in progressive multiple sclerosis

    Bramow, Stephan; Frischer, Josa M; Lassmann, Hans;

    2010-01-01

    The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive...... multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with 34 with secondary progressive disease. In patients with secondary progressive multiple sclerosis, we found larger brain plaques, more demyelination in total and higher brain loads of active demyelination...... compared with patients with primary progressive disease. In addition, the brain density of plaques with high-grade inflammation and active demyelination was highest in secondary progressive multiple sclerosis and remained ~18% higher than in primary progressive multiple sclerosis after adjustments for...

  12. MULTIPLE PROJECT MANAGEMENT IN THE CONSTRUCTION INDSUTRY

    Luciana Hazin Alencar

    2010-06-01

    Full Text Available The field of project management has historically focused on the administration of one project at a time, a focus that is insufficient given the growing need for organizations to manage multiple projects simultaneously. The requirements of Multiple Project Management (MPM involves demands and practices that are different from those of single projects. MPM poses a special need for coordination of shared resources across multiple projects in a way that can maintain the firm’s strategic focus and facilitate effective decision making. The construction industry is noteworthy for its frequent need for the management of multiple projects. This paper offers a review of the last five years of indexed literature related to multiple project management in the construction industry, identifies gaps and suggests promising new avenues of inquiry.

  13. Chromosomal radiosensitivity in patients with multiple sclerosis

    Milenkova, Maria; Milanov, Ivan; Kmetska, Ksenia [III Neurological Clinic, University Hospital Saint Naum, Sofia (Bulgaria); Deleva, Sofia; Popova, Ljubomira; Hadjidekova, Valeria [Laboratory of Radiation Genetics, NCRRP, Sofia (Bulgaria); Groudeva, Violeta [Department of Diagnostic Imaging, University Hospital St. Ekaterina, Sofia (Bulgaria); Hadjidekova, Savina [Department of Medical Genetics, Medical University, Sofia (Bulgaria); Domínguez, Inmaculada, E-mail: idomin@us.es [Department of Cell Biology, Faculty of Biology, University of Seville, Avda. Reina Mercedes 6, 41012 (Spain)

    2013-09-15

    Highlights: • We studied radiosensitivity to in vitro γ-irradiated lymphocytes from MS patients. • Immunotherapy in RRMS patients reduced the yield of radiation induced MN. • The group of treated RRMS accounts for the low radiosensitivity in MS patients. • Spontaneous yield of MN was similar in treated and untreated RRMS patients. - Abstract: Multiple sclerosis is a clinically heterogeneous autoimmune disease leading to severe neurological disability. Although during the last years many disease-modifying agents as treatment options for multiple sclerosis have been made available, their mechanisms of action are still not fully determined. In the present study radiosensitivity in lymphocytes of patients with relapsing–remitting multiple sclerosis, secondary progressive multiple sclerosis and healthy controls was investigated. Whole blood cultures from multiple sclerosis patients and healthy controls were used to analyze the spontaneous and radiation-induced micronuclei in binucleated lymphocytes. A subgroup of patients with relapsing–remitting multiple sclerosis was treated with immunomodulatory agents, interferon β or glatiramer acetate. The secondary progressive multiple sclerosis patients group was not receiving any treatment. Our results reveal that the basal DNA damage was not different between relapsing–remitting and secondary progressive multiple sclerosis patients, and healthy controls. No differences between gamma-irradiation induced micronuclei frequencies in binucleated cells from relapsing–remitting and secondary progressive multiple sclerosis patients, and healthy controls were found either. Nevertheless, when we compared the radiation induced DNA damage in binucleated cells from healthy individuals with the whole group of patients, a reduction in the frequency of micronuclei was obtained in the patients group. Induced micronuclei yield was significantly lower in the irradiated samples from treated relapsing–remitting multiple

  14. Chromosomal radiosensitivity in patients with multiple sclerosis

    Highlights: • We studied radiosensitivity to in vitro γ-irradiated lymphocytes from MS patients. • Immunotherapy in RRMS patients reduced the yield of radiation induced MN. • The group of treated RRMS accounts for the low radiosensitivity in MS patients. • Spontaneous yield of MN was similar in treated and untreated RRMS patients. - Abstract: Multiple sclerosis is a clinically heterogeneous autoimmune disease leading to severe neurological disability. Although during the last years many disease-modifying agents as treatment options for multiple sclerosis have been made available, their mechanisms of action are still not fully determined. In the present study radiosensitivity in lymphocytes of patients with relapsing–remitting multiple sclerosis, secondary progressive multiple sclerosis and healthy controls was investigated. Whole blood cultures from multiple sclerosis patients and healthy controls were used to analyze the spontaneous and radiation-induced micronuclei in binucleated lymphocytes. A subgroup of patients with relapsing–remitting multiple sclerosis was treated with immunomodulatory agents, interferon β or glatiramer acetate. The secondary progressive multiple sclerosis patients group was not receiving any treatment. Our results reveal that the basal DNA damage was not different between relapsing–remitting and secondary progressive multiple sclerosis patients, and healthy controls. No differences between gamma-irradiation induced micronuclei frequencies in binucleated cells from relapsing–remitting and secondary progressive multiple sclerosis patients, and healthy controls were found either. Nevertheless, when we compared the radiation induced DNA damage in binucleated cells from healthy individuals with the whole group of patients, a reduction in the frequency of micronuclei was obtained in the patients group. Induced micronuclei yield was significantly lower in the irradiated samples from treated relapsing–remitting multiple

  15. A Novel Multiple-Valued CMOS Flip-Flop Employing Multiple-Valued Clock

    Yin-Shui Xia; Lun-Yao Wang; A. E. A. Almaini

    2005-01-01

    A new CMOS quaternary D flip-flop is implemented employing a multiple-valued clock. Pspice simulation shows that the proposed flip-flop has correct operation. Compared with traditional multiple-valued flip-flops, the proposed multiple-valued CMOS flip-flop is characterized by improved storage capacity, flexible logic structure and reduced power dissipation.

  16. Union of sets of uniqueness for multiple Walsh and multiple trigonometric series

    For the case of convergence over rectangles of multiple Walsh and multiple trigonometric series questions on unions of sets of uniqueness, formal multiplication of series, the localization principle for integrable functions, and analogues of Privalov's theorem on the unique representation of a function by a series are considered

  17. A Unifying View of Multiple Kernel Learning

    Kloft, Marius; Bartlett, Peter L

    2010-01-01

    Recent research on multiple kernel learning has lead to a number of approaches for combining kernels in regularized risk minimization. The proposed approaches include different formulations of objectives and varying regularization strategies. In this paper we present a unifying general optimization criterion for multiple kernel learning and show how existing formulations are subsumed as special cases. We also derive the criterion's dual representation, which is suitable for general smooth optimization algorithms. Finally, we evaluate multiple kernel learning in this framework analytically using a Rademacher complexity bound on the generalization error and empirically in a set of experiments.

  18. A Study of Multiplicities in Hadronic Interactions

    Estrada Tristan, Nora Patricia; /San Luis Potosi U.

    2006-02-01

    Using data from the SELEX (Fermilab E781) experiment obtained with a minimum-bias trigger, we study multiplicity and angular distributions of secondary particles produced in interactions in the experimental targets. We observe interactions of {Sigma}{sup -}, proton, {pi}{sup -}, and {pi}{sup +}, at beam momenta between 250 GeV/c and 650 GeV/c, in copper, polyethylene, graphite, and beryllium targets. We show that the multiplicity and angular distributions for meson and baryon beams at the same momentum are identical. We also show that the mean multiplicity increases with beam momentum, and presents only small variations with the target material.

  19. Multiple factor analysis by example using R

    Pagès, Jérôme

    2014-01-01

    Multiple factor analysis (MFA) enables users to analyze tables of individuals and variables in which the variables are structured into quantitative, qualitative, or mixed groups. Written by the co-developer of this methodology, Multiple Factor Analysis by Example Using R brings together the theoretical and methodological aspects of MFA. It also includes examples of applications and details of how to implement MFA using an R package (FactoMineR).The first two chapters cover the basic factorial analysis methods of principal component analysis (PCA) and multiple correspondence analysis (MCA). The

  20. IMPROVED MLV FILTER TO REMOVE MULTIPLICATIVE NOISE

    Li Weibin; Liu Fang; Jiao Licheng; Zhang Shuling; Li Zongling

    2006-01-01

    More methods can be used to remove the additive noise, such as the Mean of Least Variance (MLV)filter. When the signal is noised by the multiplicative noise, it is difficult to remove. The paper presents an improved filter to remove multiplicative noise by changing the multiplicative noise to the additive noise, and then using the MLV-like to remove the additive noise. The simulation results show that the performance is better than Minimum Coefficient of Variation (MCV) filter and MLV filter. Both one-dimension and image experiments demonstrate its theoretical performance.

  1. New results of the extreme multiplicity studies

    Kokoulina, E; Petukhov, Yu; Karpov, A; Kutov, A

    2009-01-01

    Extreme multiplicity studies at 50 GeV in pp interactions are discussed. Preliminary multiplicity distributions at U-70 (IHEP, Protvino) energy have been obtained for more than 20 charged particles. A new elaborated algorithm for the track reconstruction in a drift tube tracker and magnetic spectrometer, has been checked . The collective behavior of secondary particles is manifested in these interactions in the extreme multiplicity region. For the first time the ring events in pp interactions have been observed in this region. A possibility of detecting the Bose-Einstein condensation detection is discussed.

  2. Multiple mediastinal hydatic cyst: a case report.

    Mohammadi, Afshin; Khodabakhsh, Maryam

    2011-01-01

    Hydatid disease is a parasitic infection that is remains endemic in many countries, particularly the Middle East and Central Asia. Mediastinal hydatidosis is very rare (less than 0.1% of all hydatid disease cases) that have been only anecdotally in the literature. To the best of our knowledge only one case of multiple mediastineal hydatid cysts has been reported previously. We report the second cases of multiple mediastineal hydatid cysts and recommend that it can be considered in the differential diagnosis of multiple cystic mediastineal masses in endemic countries. PMID:21554233

  3. Registers of multiple sclerosis in Denmark

    Koch-Henriksen, N; Magyari, M; Laursen, B

    2015-01-01

    There are two nationwide population-based registers for multiple sclerosis (MS) in Denmark. The oldest register is The Danish Multiple Sclerosis Registry (DMSR), which is an epidemiological register for estimation of prevalence and incidence of MS and survival, and for identifying exposures earlier...... between a number of different environmental exposures in the past and the subsequent risk of MS. Some of these studies have been able to exonerate suspected risk factors. The other register, the nationwide Danish Multiple Sclerosis Treatment Register, is a follow-up register for all patients who have...

  4. Neurocutaneous spectrum of multiple endocrine neoplasia-1

    Shireen Furtado

    2012-01-01

    Full Text Available Multiple endocrine neoplasia type I or Wermer syndrome is characterized by primary hyperparathyroidism, enteropancreatic endocrine tumor, and a pituitary pathology. A 35-year-old male presented with visual field defects, hyperprolactinemia, and hypogonadism. He also had multiple infraumbilical skin-colored nodules. A syndromal association of Wermer syndrome was derived using the dermal, pituitary, parathyroid, and gastrointestinal hormonal manifestations of the tumor. The radiological and histological findings of lesion which underwent biopsy are discussed. The presence of collagenomas, lipomas, and hypopigmented macules in a patient with neuroendocrine symptoms should raise the suspicion of an underlying multiple endocrine neoplasia.

  5. Charge multiplication effect in thin diamond films

    Skukan, N.; Grilj, V.; Sudić, I.; Pomorski, M.; Kada, W.; Makino, T.; Kambayashi, Y.; Andoh, Y.; Onoda, S.; Sato, S.; Ohshima, T.; Kamiya, T.; Jakšić, M.

    2016-07-01

    Herein, we report on the enhanced sensitivity for the detection of charged particles in single crystal chemical vapour deposition (scCVD) diamond radiation detectors. The experimental results demonstrate charge multiplication in thin planar diamond membrane detectors, upon impact of 18 MeV O ions, under high electric field conditions. Avalanche multiplication is widely exploited in devices such as avalanche photo diodes, but has never before been reproducibly observed in intrinsic CVD diamond. Because enhanced sensitivity for charged particle detection is obtained for short charge drift lengths without dark counts, this effect could be further exploited in the development of sensors based on avalanche multiplication and radiation detectors with extreme radiation hardness.

  6. Are multiple runs better than one?

    Cantu-Paz, E

    2001-01-04

    This paper investigates whether it is better to use a certain constant amount of computational resources in a single run with a large population, or in multiple runs with smaller populations. The paper presents the primary tradeoffs involved in this problem and identifies the conditions under which there is an advantage to use multiple small runs. The paper uses an existing model that relates the quality of the solutions reached by a GA with its population size. The results suggest that in most cases a single run with the largest population possible reaches a better solution than multiple isolated runs. The findings are validated with experiments on functions of varying difficulty.

  7. Analysis of a multiple dispatch algorithm

    Holmberg, Johannes

    2004-01-01

    The development of the new programming language Scream, within the project Software Renaissance, led to the need of a good multiple dispatch algorithm. A multiple dispatch algorithm, called Compressed n-dimensional table with row sharing; CNT-RS, was developed from the algorithm Compressed n-dimensional table, CNT. The purpose of CNT-RS was to create a more efficient algorithm. This report is the result of the work to analyse the CNT-RS algorithm. In this report the domain of multiple dispat...

  8. Multiple eruptive keratoacanthomas arising in a tattoo.

    Vitiello, Magalys; Echeverria, Begoña; Romanelli, Paolo; Abuchar, Adriana; Kerdel, Francisco

    2010-07-01

    Keratoacanthomas are rapidly growing, keratinizing, epithelial neoplasms that tend to spontaneously involute and are rarely multiple or eruptive. There is still disagreement on whether or not this condition is a malignancy or a benign epidermal neoplasm; nevertheless, its appearance on tattoos has been reported in rare instances. When waiting for spontaneous involution is not an option, surgery is the preferred treatment. Other therapeutic modalities used for the treatment of this condition include radiotherapy; cryotherapy; laser therapy; and multiple intralesional, topical, and systemic agents. The authors report a patient who developed multiple, eruptive keratoacanthomas in the red ink portions of a tattoo and was successfully treated with acitretin. PMID:20725558

  9. Conjugation properties of tensor product multiplicities

    Coquereaux, Robert

    2014-01-01

    It was recently proven that the total multiplicity in the decomposition into irreducibles of the tensor product lambda x mu of two irreducible representations of a simple Lie algebra is invariant under conjugation of one of them; at a given level, this also applies to the fusion multiplicities of affine algebras. Here, we show that, in the case of SU(3), the lists of multiplicities, in the tensor products lambda x mu and lambda x bar{mu}, are identical up to permutations. This latter property does not hold in general for other Lie algebras.

  10. Practice of using the multiple painting method

    Drapchinsky, L V; Soloviev, S M

    1999-01-01

    A technique for the preparation of homogeneous minor-actinide layers by the multiple-painting method is described in detail. The advantages of the method used, as well as characteristics of the layers, are discussed.

  11. Multiple Wheel Throwing: And Chess Sets.

    Sapiro, Maurice

    1978-01-01

    A chess set project is suggested to teach multiple throwing, the creation on a potter's wheel of several pieces of similar configuration. Processes and finished sets are illustrated with photographs. (SJL)

  12. Scorpion bite and multiple cerebral infarcts.

    Thacker A; Lal R; Misra M

    2002-01-01

    Multiple cerebral infarcts, bilateral optic neuropathy with limb ischemia, following scorpion bite is documented. Vasospasm and autonomic storm due to envenomation is a plausible explanation for this symptom complex.

  13. Surgery for Pulmonary Multiple Ground Glass Opacities

    Qun WANG

    2016-06-01

    Full Text Available The incidence of pulmonary ground glass opacity (GGO has been increasing in recent years, with a great number of patients having multiple GGOs. Unfortunately, the management of multiple GGOs is still controversial. Pulmonary GGO is a radiological term, consisting of different pathological types. Some of the GGOs are early-staged lung cancer. GGO is an indolent nodule, only a small proportion of GGOs change during observation, which does not influence the efficacy of surgery. . The timing of surgery for multiple GGOs mainly depends on the predominant nodule and surgery is recommended if the solid component of the predominant nodule >5 mm. Either lobectomy or sub-lobectomy is feasible. GGOs other than the predominant nodule can be left unresected. Multiple GGOs with high risk factors need mediastinal lymph node dissection or sampling.

  14. Chiral geometry in multiple chiral doublet bands

    Zhang, Hao

    2015-01-01

    The chiral geometry of the multiple chiral doublet bands with identical configuration is discussed for different triaxial deformation parameters $\\gamma$ in the particle rotor model with $\\pi h_{11/2}\\otimes \

  15. Multiples least-squares reverse time migration

    Zhang, D. L.

    2013-01-01

    To enhance the image quality, we propose multiples least-squares reverse time migration (MLSRTM) that transforms each hydrophone into a virtual point source with a time history equal to that of the recorded data. Since each recorded trace is treated as a virtual source, knowledge of the source wavelet is not required. Numerical tests on synthetic data for the Sigsbee2B model and field data from Gulf of Mexico show that MLSRTM can improve the image quality by removing artifacts, balancing amplitudes, and suppressing crosstalk compared to standard migration of the free-surface multiples. The potential liability of this method is that multiples require several roundtrips between the reflector and the free surface, so that high frequencies in the multiples are attenuated compared to the primary reflections. This can lead to lower resolution in the migration image compared to that computed from primaries.

  16. Influence of Impactor Size on Momentum Multiplication

    Hoerth, T.; Poelchau, M. H.; Kenkmann, T.; Hupfer, J.; Schäfer, F.

    2015-09-01

    Hypervelocity impact experiments into sandstone targets using different projectile sizes were conducted. The momentum multiplication factor increases with increasing impactor size. This is attributed to an increased amount of spallation.

  17. A canine model of multiple portosystemic shunting.

    Howe, L M; Boothe, H W; Miller, M W; Boothe, D M

    2000-01-01

    The objective of this study was to develop and describe an experimental canine model of multiple acquired portosystemic shunts (PSS) similar in nature to spontaneously occurring PSS. Sixteen dogs were used and were divided into a control (n = 6) and a diseased group (n = 10). Dogs of the diseased group were administered dimethylnitrosamine (2 mg/kg of body weight, po) twice weekly, and clinicopathologic, ultrasonographic, and hepatic scintigraphic findings were recorded during the development of hepatic disease and PSS. Surgery was then performed to permit visual verification of multiple shunts, catheter placement for portography examination, and biopsy of the liver. All diseased dogs developed severe hepatic disease and multiple PSS as documented visually at surgery and on portography. Based on this study, dimethylnitrosamine-induced portosystemic shunting appears to be an appropriate model for spontaneously occurring multiple PSS secondary to portal hypertension. PMID:10741951

  18. The Analysis of The Multiple Choice Item

    曹吴惠

    2009-01-01

    In this article, the author analyzes in detail the advantages, disadvantages and forming of the multiple choice item in examinations. On its basis, the author also exploree some aspects the teacher should pay attention to while setting an examination paper.

  19. Parabrachial nucleus involvement in multiple system atrophy☆

    Benarroch, E.E.; Schmeichel, A.M.; Low, P. A.; Parisi, J.E.

    2013-01-01

    Multiple system atrophy (MSA) is associated with respiratory dysfunction, including sleep apnea, respiratory dysrhythmia, and laryngeal stridor. Neurons of the parabrachial nucleus (PBN) control respiratory rhythmogenesis and airway resistance.

  20. Defining the clinical course of multiple sclerosis

    Lublin, Fred D; Reingold, Stephen C; Cohen, Jeffrey A;

    2014-01-01

    Accurate clinical course descriptions (phenotypes) of multiple sclerosis (MS) are important for communication, prognostication, design and recruitment of clinical trials, and treatment decision-making. Standardized descriptions published in 1996 based on a survey of international MS experts...

  1. Multiple Chronic Conditions Among Medicare Beneficiaries...

    U.S. Department of Health & Human Services — Individuals with multiple chronic conditions (MCC) present many challenges to the health care system, such as effective coordination of care and cost containment....

  2. Vitamin D Levels Predict Multiple Sclerosis Progression

    ... Research Matters NIH Research Matters February 3, 2014 Vitamin D Levels Predict Multiple Sclerosis Progression Among people ... sclerosis (MS), those with higher blood levels of vitamin D had better outcomes during 5 years of ...

  3. Application Guide to Neutron Multiplicity Counting

    D. G. Langner; J. E. Stewart; M. M. Pickrell; M. S. Krick; N. Ensslin; W. C. Harker

    1998-11-01

    This document is intended to serve as a comprehensive applications guide to passive neutron multiplicity counting, a new nondestructive assay (NDA) technique developed over the past ten years. The document describes the principles of multiplicity counter design, electronics, and mathematics. Existing counters in Department of Energy (DOE) facilities are surveyed, and their operating requirements and procedures and defined. Current applications to plutonium material types found in DOE facilities are described, and estimates of the expected assay precision and bias are given. Lastly, guidelines for multiplicity counter selection and procurement are summarized. The document also includes a detailed collection of references on passive neutron coincidence and multiplicity publications over the last ten to fifteen years.

  4. Multiple Surveys of Students and Survey Fatigue

    Porter, Stephen R.; Whitcomb, Michael E.; Weitzer, William H.

    2004-01-01

    This chapter reviews the literature on survey fatigue and summarizes a research project that indicates that administering multiple surveys in one academic year can significantly suppress response rates in later surveys. (Contains 4 tables.)

  5. CDC WONDER: Mortality - Multiple Cause of Death

    U.S. Department of Health & Human Services — The Mortality - Multiple Cause of Death data on CDC WONDER are county-level national mortality and population data spanning the years 1999-2006. These data are...

  6. Genetics Home Reference: multiple system atrophy

    ... atrophy , known as MSA-C, is characterized by cerebellar ataxia , which causes problems with coordination and balance. This ... System Disorders Health Topic: Balance Problems Health Topic: Degenerative Nerve ... type MalaCards: multiple system atrophy, parkinsonian type Merck ...

  7. CDC WONDER: Mortality - Multiple Cause of Death

    U.S. Department of Health & Human Services — The Mortality - Multiple Cause of Death data on CDC WONDER are county-level national mortality and population data spanning the years 1999-2009. Data are based on...

  8. Recent advances in multiple sclerosis therapy

    Seven papers in this volume are in INIS scope, one dealing with autoradiographic detection of multiple sclerosis plaques with radiologands, and the others with magnetic resonance imaging of MS lesions. (H.W.). refs.; figs.; tabs

  9. Connectedness in Multiple Linear Fractional Programming

    Choo, E.U.; D. R. Atkins

    1983-01-01

    The geometric properties of the sets of efficient and weakly efficient solutions of multiple linear fractional programming problems are investigated. Weakly efficient solutions are path-connected by finitely many linear line segments when the constrained region is compact.

  10. Complementary and Alternative Medicine for Multiple Sclerosis

    ... of multiple sclerosis (MS). The American Academy of Neurology (AAN) is the world’s largest association of neurologists ... modifying and symptomatic treatments. ©2014 American Academy of Neurology AAN. com What is CAM therapy? How does ...

  11. Appendicitis - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Appendicitis URL of this page: https://medlineplus.gov/languages/appendicitis.html Other topics A-Z A B ...

  12. Blood Sugar - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Blood Sugar URL of this page: https://medlineplus.gov/languages/bloodsugar.html Other topics A-Z A B ...

  13. Breastfeeding - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Breastfeeding URL of this page: https://medlineplus.gov/languages/breastfeeding.html Other topics A-Z A B ...

  14. Breast Reconstruction - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Breast Reconstruction URL of this page: https://medlineplus.gov/languages/breastreconstruction.html Other topics A-Z A B ...

  15. Carbohydrates - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Carbohydrates URL of this page: https://medlineplus.gov/languages/carbohydrates.html Other topics A-Z A B ...

  16. Advance Directives - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Advance Directives URL of this page: https://medlineplus.gov/languages/advancedirectives.html Other topics A-Z A B ...

  17. Blood Disorders - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Blood Disorders URL of this page: https://medlineplus.gov/languages/blooddisorders.html Other topics A-Z A B ...

  18. Alzheimer's Disease - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Alzheimer's Disease URL of this page: https://medlineplus.gov/languages/alzheimersdisease.html Other topics A-Z A B ...

  19. Breast Diseases - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Breast Diseases URL of this page: https://medlineplus.gov/languages/breastdiseases.html Other topics A-Z A B ...

  20. Breast Cancer - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Breast Cancer URL of this page: https://medlineplus.gov/languages/breastcancer.html Other topics A-Z A B ...

  1. Atrial Fibrillation - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Atrial Fibrillation URL of this page: https://medlineplus.gov/languages/atrialfibrillation.html Other topics A-Z A B ...

  2. Bone Diseases - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Bone Diseases URL of this page: https://medlineplus.gov/languages/bonediseases.html Other topics A-Z A B ...

  3. Anal Disorders - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Anal Disorders URL of this page: https://medlineplus.gov/languages/analdisorders.html Other topics A-Z A B ...

  4. Arrhythmia - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Arrhythmia URL of this page: https://medlineplus.gov/languages/arrhythmia.html Other topics A-Z A B ...

  5. Bladder Diseases - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Bladder Diseases URL of this page: https://medlineplus.gov/languages/bladderdiseases.html Other topics A-Z A B ...

  6. Angioplasty - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Angioplasty URL of this page: https://medlineplus.gov/languages/angioplasty.html Other topics A-Z A B ...

  7. Animal Bites - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Animal Bites URL of this page: https://medlineplus.gov/languages/animalbites.html Other topics A-Z A B ...

  8. Brain Diseases - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Brain Diseases URL of this page: https://medlineplus.gov/languages/braindiseases.html Other topics A-Z A B ...

  9. Bacterial Infections - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Bacterial Infections URL of this page: https://medlineplus.gov/languages/bacterialinfections.html Other topics A-Z A B ...

  10. Caregivers - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Caregivers URL of this page: https://medlineplus.gov/languages/caregivers.html Other topics A-Z A B ...

  11. Bone Cancer - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Bone Cancer URL of this page: https://medlineplus.gov/languages/bonecancer.html Other topics A-Z A B ...

  12. Breathing Problems - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Breathing Problems URL of this page: https://medlineplus.gov/languages/breathingproblems.html Other topics A-Z A B ...

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    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Acute Bronchitis URL of this page: https://medlineplus.gov/languages/acutebronchitis.html Other topics A-Z A B ...

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    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Cervical Cancer URL of this page: https://medlineplus.gov/languages/cervicalcancer.html Other topics A-Z A B ...

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    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Alzheimer's Caregivers URL of this page: https://medlineplus.gov/languages/alzheimerscaregivers.html Other topics A-Z A B ...

  16. Arthritis - Multiple Languages: MedlinePlus

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Arthritis URL of this page: https://medlineplus.gov/languages/arthritis.html Other topics A-Z A B ...

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    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → After Surgery URL of this page: https://medlineplus.gov/languages/aftersurgery.html Other topics A-Z A B ...

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    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Blood Thinners URL of this page: https://medlineplus.gov/languages/bloodthinners.html Other topics A-Z A B ...

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    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Aneurysms URL of this page: https://medlineplus.gov/languages/aneurysms.html Other topics A-Z A B ...

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    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Back Injuries URL of this page: https://medlineplus.gov/languages/backinjuries.html Other topics A-Z A B ...