Impact of actuarial assumptions on pension costs: A simulation analysis
Yusof, Shaira; Ibrahim, Rose Irnawaty
2013-04-01
This study investigates the sensitivity of pension costs to changes in the underlying assumptions of a hypothetical pension plan in order to gain a perspective on the relative importance of the various actuarial assumptions via a simulation analysis. Simulation analyses are used to examine the impact of actuarial assumptions on pension costs. There are two actuarial assumptions will be considered in this study which are mortality rates and interest rates. To calculate pension costs, Accrued Benefit Cost Method, constant amount (CA) modification, constant percentage of salary (CS) modification are used in the study. The mortality assumptions and the implied mortality experience of the plan can potentially have a significant impact on pension costs. While for interest rate assumptions, it is inversely related to the pension costs. Results of the study have important implications for analyst of pension costs.
Teachers Retirement System of Louisiana, Baton Rouge.
This report presents the results of the actuarial valuation of assets and liabilities as well as funding requirements for the Teachers Retirement System of Louisiana as of June 30, 1996. Data reported include current funding, actuarial assets and valuation assets. These include the Louisiana State University Agriculture and Extension Service Fund,…
U.S. Department of Health & Human Services — The Office of the Actuary in the Centers for Medicare and Medicaid Services (CMS) from time to time conducts studies on various aspects of the Medicare and Medicaid...
An analysis of possible applications of fuzzy set theory to the actuarial credibility theory
Ostaszewski, Krzysztof; Karwowski, Waldemar
1992-01-01
In this work, we review the basic concepts of actuarial credibility theory from the point of view of introducing applications of the fuzzy set-theoretic method. We show how the concept of actuarial credibility can be modeled through the fuzzy set membership functions and how fuzzy set methods, especially fuzzy pattern recognition, can provide an alternative tool for estimating credibility.
Jørgensen, Peter Løchte; Slipsager, Søren Kærgaard
2015-01-01
This paper provides the explicit solution to the three-factor diffusion model recently proposed by the Danish Society of Actuaries to the Danish industry of life insurance and pensions. The solution is obtained by use of the known general solution to multidimensional linear stochastic differential...... minimize discretization errors. Using our exact simulation scheme, one is able to cut these computational costs significantly and obtain even better forecasts. As probability density tail behavior is key to expected investment portfolio performance, we further conduct a risk analysis in which we compare...... well-known risk measures under both schemes. Finally, we conduct a sensitivity analysis and find that the relative performance of the two schemes depends on the chosen model parameter estimates....
The Casualty Actuarial Society: Helping Universities Train Future Actuaries
Boa, J. Michael; Gorvett, Rick
2014-01-01
The Casualty Actuarial Society (CAS) believes that the most effective way to advance the actuarial profession is to work in partnership with universities. The CAS stands ready to assist universities in creating or enhancing courses and curricula associated with property/casualty actuarial science. CAS resources for university actuarial science…
Wamala, Robert; Maswere, Dyson W.; Mwanga, Yeko
2013-01-01
This study investigates the role of prior grounding attained in mathematics in predicting the academic achievement of enrollees in Bachelor of Science in Actuarial Science (BSAS). The investigation is based on administrative records of 240 BSAS enrollees at Makerere University, School of Statistics and Planning in the 2007-2009 cohorts. Students'…
Health insurance basic actuarial models
Pitacco, Ermanno
2014-01-01
Health Insurance aims at filling a gap in actuarial literature, attempting to solve the frequent misunderstanding in regards to both the purpose and the contents of health insurance products (and ‘protection products’, more generally) on the one hand, and the relevant actuarial structures on the other. In order to cover the basic principles regarding health insurance techniques, the first few chapters in this book are mainly devoted to the need for health insurance and a description of insurance products in this area (sickness insurance, accident insurance, critical illness covers, income protection, long-term care insurance, health-related benefits as riders to life insurance policies). An introduction to general actuarial and risk-management issues follows. Basic actuarial models are presented for sickness insurance and income protection (i.e. disability annuities). Several numerical examples help the reader understand the main features of pricing and reserving in the health insurance area. A short int...
Application of Actuarial Modelling in Insurance Industry
Burcã Ana-Maria; Bãtrînca Ghiorghe
2011-01-01
In insurance industry, the financial stability of insurance companies represents an issue of vital importance. In order to maintain the financial stability and meet minimum regulatory requirements, actuaries apply actuarial modeling. Modeling has been at the center of actuarial science and of all the sciences from the beginning of their journey. In insurance industry, actuarial modeling creates a framework that allows actuaries to identify, understand, quantify and manage a wide range of risk...
An actuarial approach to motor insurance rating
Coutts, S.M.
1983-01-01
This thesis describes an actuarial structure for the practical analysis of motor insurance premium rating. An underlying theme emphasises that judgements are being made taking into account many factors e.g. economical, statistical and technical, therefore it is necessary to bring into the decision process a group of interested persons. In addition even though data are used to explain the proposed methods, it is the framework which is important and not the omission of some of the data e.g. imp...
Actuarial applications of financial models.
Goovaerts, Marc; Dhaene, Jan
1996-01-01
In the present contribution we indicate the type of situations seen from an insurance point of view, in which financial models serve as a basis for providing solutions to practical problems . In addition, some of the essential differences in the basic assumptions underlying financial models and actuarial applications are given.
Mathematical and statistical methods for actuarial sciences and finance
Pizzi, Claudio
2014-01-01
The interaction between mathematicians and statisticians has been shown to be an eﬀective approach for dealing with actuarial, insurance and ﬁnancial problems, both from an academic perspective and from an operative one. The collection of original papers presented in this volume pursues precisely this purpose. It covers a wide variety of subjects in actuarial, insurance and ﬁnance ﬁelds, all treated in the light of the successful cooperation between the above two quantitative approaches. The papers published in this volume present theoretical and methodological contributions and their applications to real contexts. With respect to the theoretical and methodological contributions, some of the considered areas of investigation are: actuarial models; alternative testing approaches; behavioral ﬁnance; clustering techniques; coherent and non-coherent risk measures; credit scoring approaches; data envelopment analysis; dynamic stochastic programming; ﬁnancial contagion models; ﬁnancial ratios; intelli...
Mathematical and statistical methods for actuarial sciences and finance
Sibillo, Marilena
2014-01-01
The interaction between mathematicians and statisticians working in the actuarial and financial fields is producing numerous meaningful scientific results. This volume, comprising a series of four-page papers, gathers new ideas relating to mathematical and statistical methods in the actuarial sciences and finance. The book covers a variety of topics of interest from both theoretical and applied perspectives, including: actuarial models; alternative testing approaches; behavioral finance; clustering techniques; coherent and non-coherent risk measures; credit-scoring approaches; data envelopment analysis; dynamic stochastic programming; financial contagion models; financial ratios; intelligent financial trading systems; mixture normality approaches; Monte Carlo-based methodologies; multicriteria methods; nonlinear parameter estimation techniques; nonlinear threshold models; particle swarm optimization; performance measures; portfolio optimization; pricing methods for structured and non-structured derivatives; r...
75 FR 63505 - Renewal of Advisory Committee on Actuarial Examinations
2010-10-15
... ENROLLMENT OF ACTUARIES Renewal of Advisory Committee on Actuarial Examinations AGENCY: Joint Board for the... of Actuaries announces the renewal of the Advisory Committee on Actuarial Examinations. FOR FURTHER... Committee is to advise the Joint Board on examinations in actuarial mathematics and methodology. The...
Developing an Actuarial Track Utilizing Existing Resources
Rodgers, Kathy V.; Sarol, Yalçin
2014-01-01
Students earning a degree in mathematics often seek information on how to apply their mathematical knowledge. One option is to follow a curriculum with an actuarial emphasis designed to prepare students as an applied mathematician in the actuarial field. By developing only two new courses and utilizing existing courses for Validation by…
Actuarial statistics with generalized linear mixed models
K. Antonio; J. Beirlant
2007-01-01
Over the last decade the use of generalized linear models (GLMs) in actuarial statistics has received a lot of attention, starting from the actuarial illustrations in the standard text by McCullagh and Nelder [McCullagh, P., Nelder, J.A., 1989. Generalized linear models. In: Monographs on Statistics
20 CFR 901.2 - Eligibility to perform actuarial services.
2010-04-01
... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Eligibility to perform actuarial services... GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 Definitions and Eligibility To Perform Actuarial Services § 901.2 Eligibility to perform actuarial...
42 CFR 403.258 - Statement of actuarial opinion.
2010-10-01
... 42 Public Health 2 2010-10-01 2010-10-01 false Statement of actuarial opinion. 403.258 Section 403... Program: Loss Ratio Provisions § 403.258 Statement of actuarial opinion. (a) For purposes of certification... actuarial opinion means a signed declaration in which a qualified actuary states that the assumptions...
Recruiting and Advising Challenges in Actuarial Science
Case, Bettye Anne; Guan, Yuanying Michelle; Paris, Stephen
2014-01-01
Some challenges to increasing actuarial science program size through recruiting broadly among potential students are identified. Possible solutions depend on the structures and culture of the school. Up to three student cohorts may result from partition of potential students by the levels of academic progress before program entry: students…
Starting an Actuarial Program with Existing Resources
Taylor, Paul T.
2014-01-01
Many institutions wish to offer a path for students pursuing actuarial careers but lack the student demand to offer new courses or hire additional faculty. Fortunately, a program training students to enter the profession can often be constructed using existing courses and well-informed advising.
Lore, Ryan; Gabel, Jon R; McDevitt, Roland; Slover, Michael
2012-08-01
In the health insurance exchanges that will come online in 2014, consumers will be able to compare health plans with respect to actuarial value, or the percentage of health care costs that a plan would pay for a standard population. This analysis illustrates the out-of-pocket costs that might result from plans with various plan designs and actuarial values. We find that average out-of-pocket expense declines as actuarial values rise, but two plans with similar actuarial values can produce very different outcomes for a given person. The overall affordability of a plan also will be influenced by age rating, income-related premium subsidies, and out-of-pocket subsidies. Actuarial value is a useful starting point for selecting a plan, but it does not pinpoint which plan will produce the best overall value for a particular person. PMID:22946140
Actuarial Nonequivalence in Early and Delayed Social Security Benefit Claims
James E. Duggan; Soares, Christopher J.
2002-01-01
Age-related adjustments to Social Security benefits are intended to be actuarially equivalent, on average, rendering lifetime benefits invariant to the timing of first receipt. This article analyzes actuarial equivalence with respect to early and delayed Social Security benefit claims using a large sample of current and former retired-worker beneficiaries. We find substantial deviations from actuarial equivalence that have resulted in â€œactuarial premiumsâ€ for males, particularly low-income...
5 CFR 839.1115 - What is an actuarial reduction?
2010-01-01
... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What is an actuarial reduction? 839.1115... COVERAGE CORRECTIONS ACT Effect of Election General Provisions § 839.1115 What is an actuarial reduction? An actuarial reduction allows you to receive benefits without having to pay an amount due in a...
Some Actuarial Formula of Life Insurance for Fuzzy Markets
Qiaoyu Huang; Liang Lin; Tao Sun
2011-01-01
This paper presents an actuarial model of life insurance for fuzzy markets based on Liu process. At first, some researches about an actuarial model of life insurance for stochastic market and concepts about fuzzy process have been reviewed. Then, an actuarial model of life insurance for fuzzy process is formulated.
29 CFR 4231.10 - Actuarial calculations and assumptions.
2010-07-01
... 29 Labor 9 2010-07-01 2010-07-01 false Actuarial calculations and assumptions. 4231.10 Section... MULTIEMPLOYER PLANS § 4231.10 Actuarial calculations and assumptions. (a) Most recent valuation. All calculations required by this part must be based on the most recent actuarial valuation as of the date...
Actuarial considerations of medical malpractice evaluations in M&As.
Frese, Richard C
2014-11-01
To best project an actuarial estimate for medical malpractice exposure for a merger and acquisition, a organization's leaders should consider the following factors, among others: How to support an unbiased actuarial estimation. Experience of the actuary. The full picture of the organization's malpractice coverage. The potential for future loss development. Frequency and severity trends. PMID:25647911
An actuarial approach to retrofit savings in buildings
Subbarao, Krishnappa; Etingov, Pavel V.; Reddy, T. A.
2014-01-01
An actuarial method has been developed for determining energy savings from retrofits from energy use data for a number of buildings. This method should be contrasted with the traditional method of using pre- and post-retrofit data on the same building. This method supports the U.S. Department of Energy Building Performance Database of real building performance data and related tools that enable engineering and financial practitioners to evaluate retrofits. The actuarial approach derives, from the database, probability density functions (PDFs) for energy savings from retrofits by creating peer groups for the user’s pre post buildings. From the energy use distribution of the two groups, the savings PDF is derived. This provides the basis for engineering analysis as well as financial risk analysis leading to investment decisions. Several technical issues are addressed: The savings PDF is obtained from the pre- and post-PDF through a convolution. Smoothing using kernel density estimation is applied to make the PDF more realistic. The low data density problem can be mitigated through a neighborhood methodology. Correlations between pre and post buildings are addressed to improve the savings PDF. Sample size effects are addressed through the Kolmogorov--Smirnov tests and quantile-quantile plots.
Actuarial pricing of energy efficiency projects: lessons foul and fair
Recent market convulsions in the energy industry have generated a plethora of post-mortem analyses on a wide range of issues, including accounting rules, corporate governance, commodity markets, and energy policy. While most of these analyses have focused on business practices related to wholesale energy trading, there has been limited analysis of retail energy services, particularly energy efficiency projects. We suggest that there were several business concepts and strategies in the energy efficiency arena whose inherent value may have been masked by the larger failure of companies such as Enron. In this paper, we describe one such concept, namely, actuarial pricing of energy efficiency projects, which leverages a portfolio-based approach to risk management. First, we discuss the business drivers, contrasting this approach with conventional industry practice. We then describe the implementation of this approach, including an actuarial database, pricing curves, and a pricing process compatible with commodity pricing. We conclude with a discussion of the prospects and barriers for the further development of transparent and quantifiable risk management products for energy efficiency, a prerequisite for developing energy efficiency as a tradeable commodity. We address these issues from an experiential standpoint, drawing mostly on our experience in developing and implementing such strategies at Enron
20 CFR 200.9 - Selection of members of Actuarial Advisory Committee.
2010-04-01
... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Selection of members of Actuarial Advisory... ADMINISTRATION § 200.9 Selection of members of Actuarial Advisory Committee. (a) Introduction. Under section 15(f... actuaries to serve on an Actuarial Advisory Committee. This section describes how the two actuaries...
An Application of Actuarial Methods in Psychiatric Diagnosis
Overall, John E.; Higgins, C. Wayne
1977-01-01
This research provides an initial evaluation of an actuarial diagnostic testing program that is being conducted by the Psychometric Laboratory at the University of Texas Medical Branch, Galveston, Texas. It was hoped that an actuarial program for psychiatric diagnosis would create greater efficiency, lower cost, and superior validity with respect…
Actuarial models of life insurance with stochastic interest rate
Wei, Xiang; Hu, Ping
2009-07-01
On the basis of general actuarial model of life insurance, this article has carried on research to continuous life insurance actuarial models under the stochastic interest rate separately. And it provide net single premium for life insurance and life annuity due over a period based on that de Moivre law of mortality and Makeham's law of mortality separately.
Potential Utility of Actuarial Methods for Identifying Specific Learning Disabilities
Benson, Nicholas; Newman, Isadore
2010-01-01
This article describes how actuarial methods can supplant discrepancy models and augment problem solving and Response to Intervention (RTI) efforts by guiding the process of identifying specific learning disabilities (SLD). Actuarial methods use routinized selection and execution of formulas derived from empirically established relationships to…
Development of an Actuarial Science Program at Salisbury University
Wainwright, Barbara A.
2014-01-01
This paper focuses on the development of an actuarial science track for the mathematics major at Salisbury University (SU). A timeline from the initial investigation into such a program through the proposal and approval processes is shared for those who might be interested in developing a new actuarial program. It is wise to start small and take…
Actuarial survival of a large Canadian cohort of preterm infants
Ohlsson Arne
2005-11-01
Full Text Available Abstract Background The increased survival of preterm and very low birth weight infants in recent years has been well documented but continued surveillance is required in order to monitor the effects of new therapeutic interventions. Gestation and birth weight specific survival rates most accurately reflect the outcome of perinatal care. Our aims were to determine survival to discharge for a large Canadian cohort of preterm infants admitted to the neonatal intensive care unit (NICU, and to examine the effect of gender on survival and the effect of increasing postnatal age on predicted survival. Methods Outcomes for all 19,507 infants admitted to 17 NICUs throughout Canada between January 1996 and October 1997 were collected prospectively. Babies with congenital anomalies were excluded from the study population. Gestation and birth weight specific survival for all infants with birth weight Results Survival to discharge at 24 weeks gestation was 54%, compared to 82% at 26 weeks and 95% at 30 weeks. In infants with birth weights 600–699, survival to discharge was 62%, compared to 79% at 700–799 g and 96% at 1,000–1,099 g. In infants born at 24 weeks gestational age, survival was higher in females but there were no significant gender differences above 24 weeks gestation. Actuarial analysis showed that risk of death was highest in the first 5 days. For infants born at 24 weeks gestation, estimated survival probability to 48 hours, 7 days and 4 weeks were 88 (CI 84,92%, 70 (CI 64, 76% and 60 (CI 53,66% respectively. For smaller birth weights, female survival probabilities were higher than males for the first 40 days of life. Conclusion Actuarial analysis provides useful information when counseling parents and highlights the importance of frequently revising the prediction for long term survival particularly after the first few days of life.
42 CFR 457.431 - Actuarial report for benchmark-equivalent coverage.
2010-10-01
... 42 Public Health 4 2010-10-01 2010-10-01 false Actuarial report for benchmark-equivalent coverage... GRANTS TO STATES State Plan Requirements: Coverage and Benefits § 457.431 Actuarial report for benchmark... § 457.430, the State must submit to CMS an actuarial report that contains an actuarial opinion that...
77 FR 63337 - Renewal of Charter of Advisory Committee on Actuarial Examinations
2012-10-16
... ENROLLMENT OF ACTUARIES Renewal of Charter of Advisory Committee on Actuarial Examinations AGENCY: Joint... Committee on Actuarial Examinations. FOR FURTHER INFORMATION CONTACT: Patrick McDonough, 202-622-8225... advise the Joint Board for the Enrollment of Actuaries (Joint Board) on examinations in...
20 CFR 901.20 - Standards of performance of actuarial services.
2010-04-01
... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Standards of performance of actuarial... GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974 Standards of Performance for Enrolled Actuaries § 901.20 Standards of performance of actuarial services....
42 CFR 440.340 - Actuarial report for benchmark-equivalent coverage.
2010-10-01
... 42 Public Health 4 2010-10-01 2010-10-01 false Actuarial report for benchmark-equivalent coverage... Benefit and Benchmark-Equivalent Coverage § 440.340 Actuarial report for benchmark-equivalent coverage. (a... described in § 440.335, must include an actuarial report. The actuarial report must contain an...
1st International Congress on Actuarial Science and Quantitative Finance
Garrido, José; Hernández-Hernández, Daniel; ICASQF
2015-01-01
Featuring contributions from industry and academia, this volume includes chapters covering a diverse range of theoretical and empirical aspects of actuarial science and quantitative finance, including portfolio management, derivative valuation, risk theory and the economics of insurance. Developed from the First International Congress on Actuarial Science and Quantitative Finance, held at the Universidad Nacional de Colombia in Bogotá in June 2014, this volume highlights different approaches to issues arising from industries in the Andean and Carribean regions. Contributions address topics such as Reverse mortgage schemes and urban dynamics, modeling spot price dynamics in the electricity market, and optimizing calibration and pricing with SABR models.
Starting an Actuarial Science Major at a Liberal Arts College
Mills, Mark A.
2014-01-01
The article provides details of the process of starting an actuarial science major at a small, liberal arts college. Some critique of the major is included, as well as some challenges that may be faced by others wanting to start such a major at their institution.
Predicting Success for Actuarial Students in Undergraduate Mathematics Courses
Smith, Richard Manning; Schumacher, Phyllis A.
2005-01-01
A study of undergraduate actuarial graduates found that math SAT scores, verbal SAT scores, percentile rank in high school graduating class, and percentage score on a college mathematics placement exam had some relevance to forecasting the students' grade point averages in their major. For both males and females, percentile rank in high school…
Actuarial Science at One Four-Year Comprehensive University
Charlwood, Kevin E.
2014-01-01
Building an Actuarial Science program designated as advanced requires dedicated faculty, support from the administration, and a core group of strong students. Washburn University may serve as a model for those wishing to start or enhance such a program at their institution. We face three main ongoing challenges: first, the hiring and retention of…
Some positive dependence notions, with applications in actuarial sciences
Denuit, M; Dhaene, Jan; Ribas, C
1999-01-01
The paper is devoted to the study of several notions of positive dependence among risks, namely association, linear positive quadrant dependence, positive orthant dependence and conditional increasingness in sequence. Various examples illustrate the usefulness of these notions in an actuarial context.
An Overview of the Society of Actuaries and Its Education Programs
Klugman, Stuart; Long, Gena
2014-01-01
The Society of Actuaries (SOA) is the world's largest actuarial organization. This article describes the SOA with particular attention paid to its education and qualification processes and resources available for university and college programs.
Strategic Curricular Decisions in Butler University's Actuarial Science Major
Wilson, Christopher James
2014-01-01
We describe specific curricular decisions employed at Butler University that have resulted in student achievement in the actuarial science major. The paper includes a discussion of how these decisions might be applied in the context of a new actuarial program.
Including an Exam P/1 Prep Course in a Growing Actuarial Science Program
Wakefield, Thomas P.
2014-01-01
The purpose of this article is to describe the actuarial science program at our university and the development of a course to enhance students' problem solving skills while preparing them for Exam P/1 of the Society of Actuaries (SOA) and the Casualty Actuary Society (CAS). The Exam P/1 prep course, formally titled Mathematical Foundations of…
29 CFR 2520.104-42 - Waiver of certain actuarial information in the annual report.
2010-07-01
... 29 Labor 9 2010-07-01 2010-07-01 false Waiver of certain actuarial information in the annual... Reporting and Disclosure Requirements § 2520.104-42 Waiver of certain actuarial information in the annual... ERISA that the annual report include as part of the actuarial statement (Schedule B) 1 the present...
2010-11-09
... Monthly Actuarial Rates, Premium Rate, and Annual Deductible Beginning January 1, 2011 AGENCY: Centers for... actuarial rates for aged (age 65 and over) and disabled (under age 65) beneficiaries enrolled in Part B of... certain threshold amounts. The monthly actuarial rates for 2011 are $230.70 for aged enrollees and...
26 CFR 301.6692-1 - Failure to file actuarial report.
2010-04-01
... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Failure to file actuarial report. 301.6692-1... Assessable Penalties Additions to the Tax and Additional Amounts § 301.6692-1 Failure to file actuarial... the actuarial report described in section 6059 and § 301.6059-1 within the time prescribed, the...
2012-11-21
... Monthly Actuarial Rates, Premium Rate, and Annual Deductible Beginning January 1, 2013 AGENCY: Centers for... actuarial rates for aged (age 65 and over) and disabled (under age 65) beneficiaries enrolled in Part B of... certain threshold amounts. The monthly actuarial rates for 2013 are $209.80 for aged enrollees and...
The Undergraduate Statistics Major--A Prelude to Actuarial Science Training.
Ratliff, Michael I.; Williams, Raymond E.
Recently there has been increased interest related to the Actuarial Science field. An actuary is a business professional who uses mathematical skills to define, analyze, and solve financial and social problems. This paper examines: (1) the interface between Statistical and Actuarial Science training; (2) statistical courses corresponding to…
2013-10-30
... Monthly Actuarial Rates, Premium Rate, and Annual Deductible Beginning January 1, 2014 AGENCY: Centers for... actuarial rates for aged (age 65 and over) and disabled (under age 65) beneficiaries enrolled in Part B of... certain threshold amounts. The monthly actuarial rates for 2014 are $209.80 for aged enrollees and...
20 CFR 901.32 - Receipt of information concerning enrolled actuaries.
2010-04-01
... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Receipt of information concerning enrolled actuaries. 901.32 Section 901.32 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE PERFORMANCE OF ACTUARIAL SERVICES UNDER THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF...
The Role of an Actuarial Director in the Development of an Introductory Program
Staples, Susan G.
2014-01-01
We describe the roles and duties of a director in developing an introductory actuarial program. Degree plan design, specialized exam courses, internship classes, coordination of efforts with Economics and Finance Departments, opportunities for creating a minor in actuarial mathematics, actuarial clubs, career advice, and interaction with actuarial…
Of pacemakers and statistics: the actuarial method extended.
Dussel, J; Wolbarst, A B; Scott-Millar, R N; Obel, I W
1980-01-01
Pacemakers cease functioning because of either natural battery exhaustion (nbe) or component failure (cf). A study of four series of pacemakers shows that a simple extension of the actuarial method, so as to incorporate Normal statistics, makes possible a quantitative differentiation between the two modes of failure. This involves the separation of the overall failure probability density function PDF(t) into constituent parts pdfnbe(t) and pdfcf(t). The approach should allow a meaningful comparison of the characteristics of different pacemaker types. PMID:6160497
Prácticas de Visual Basic aplicado al cálculo actuarial
Boj del Val, Eva; Claramunt Bielsa, M. Mercè; Morillo, Isabel
2006-01-01
[eng] This publication includes three examples of application of the Visual Basic programming language to actuarial and financial calculus. It contains the material of practical classes of the course Visual Basic aplicat al càlcul actuarial organized by the Departament de Matemàtica Econòmica, Financera i Actuarial of the Universitat de Barcelona. The objective is a docent one, so the programs included have been elaborated in a didactical way.
2011-12-28
..., 2011 (76 FR 17762) relating to the enrollment of actuaries. DATES: This correction is effective on..., the publication of the final regulations (TD 9517) which were the subject of FR Doc. 2011-7573 is... ENROLLMENT OF ACTUARIES 20 CFR Part 901 RIN 1545-BC82 Regulations Governing the Performance of...
Is More Better? Combining Actuarial Risk Scales to Predict Recidivism among Adult Sex Offenders
Seto, Michael C.
2005-01-01
The present study was conducted to determine whether combining the results of multiple actuarial risk scales increases accuracy in predicting sex offender recidivism. Multiple methods of combining 4 validated actuarial risk scales--the Violence Risk Appraisal Guide, the Sex Offender Risk Appraisal Guide, the Rapid Risk Assessment for Sexual…
Actuarial Prediction of Performance in a Six-Year A.B.-M.D. Program
Hess, Thomas G.; Brown, Donald R.
1977-01-01
Four actuarial equations for predicting an academic performance criterion were developed and assessed at the University of Michigan. It was concluded that appropriately done actuarial prediction of an individual criterion is more efficient than the efforts of an admissions committee. (LBH)
Risk Assessment in Child Protective Services: Consensus and Actuarial Model Reliability.
Baird, Christopher; Wagner, Dennis; Healy, Theresa; Johnson, Kristen
1999-01-01
Compared reliability of three widely used child protective service risk-assessment models (one actuarial, two consensus based). Found that, although no system approached 100% interrater reliability, raters employing the actuarial model made consistent estimates of risk for a high percentage of cases they assessed. Interrater reliability for the…
Clinical versus Actuarial Predictions of Violence in Patients with Mental Illness.
Gardner, William; And Others
1996-01-01
Compared accuracy of an actuarial procedure for the prediction of community violence by patients with mental illnesses to accuracy of clinicians' concern ratings of patient violence. Data came from a study of 357 pairs of patients seen in a psychiatric emergency room. Actuarial predictions based only on patients' histories of violence were more…
Criminal Behavior as a Function of Clinical and Actuarial Variables in a Sexual Offender Population.
Hall, Gordon C. Nagayama
1988-01-01
Investigated ability of clinical and actuarial variables to predict criminal behavior of 342 sexual offenders previously studied in 1987. Results suggested linear combination of actuarial variables was significantly predictive of sexual reoffenses against adults and of nonsexual reoffending. Clinical judgment was not significantly predictive of…
5 CFR 839.1119 - How is the actuarial reduction for TSP computed?
2010-01-01
... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false How is the actuarial reduction for TSP... actuarial reduction for TSP computed? (a) The part of your TSP account on the date you retired that is Government contributions and earnings on those Government contributions forms the basis for the...
Schumacher, Phyllis; Olinsky, Alan; Quinn, John; Smith, Richard
2010-01-01
The authors extended previous research by 2 of the authors who conducted a study designed to predict the successful completion of students enrolled in an actuarial program. They used logistic regression to determine the probability of an actuarial student graduating in the major or dropping out. They compared the results of this study with those…
2010-08-06
... From the Federal Register Online via the Government Publishing Office RAILROAD RETIREMENT BOARD Actuarial Advisory Committee With Respect to the Railroad Retirement Account; Notice of Public Meeting Notice is hereby given in accordance with Public Law 92-463 that the Actuarial Advisory Committee...
2011-11-02
... From the Federal Register Online via the Government Publishing Office RAILROAD RETIREMENT BOARD Actuarial Advisory Committee With Respect to the Railroad Retirement Account; Notice of Public Meeting Notice is hereby given in accordance with Public Law 92-463 that the Actuarial Advisory Committee...
2012-04-23
... From the Federal Register Online via the Government Publishing Office RAILROAD RETIREMENT BOARD Actuarial Advisory Committee With Respect to the Railroad Retirement Account; Notice of Public Meeting Notice is hereby given in accordance with Public Law 92-463 that the Actuarial Advisory Committee...
2012-03-01
... Board shall review DoD actuarial methods and assumptions to be used in the valuation of benefits under DoD retiree health care programs for Medicare-eligible beneficiaries. Agenda: 1. Meeting Objective... Actuarial Valuation Results 5. September 30, 2011 Actuarial Valuation Proposals 6. Decisions...
2010-02-09
... used in the valuation of benefits under DoD retiree health care programs for Medicare-eligible beneficiaries. Agenda --Meeting objective (Board) Approve actuarial assumptions and methods needed for...) --September 30, 2008 Actuarial Valuation Results (DoD Office of the Actuary) --September 30, 2009...
Modelización actuarial de las nuevas prestaciones sociales en Venezuela
Evaristo Diz Cruz
2014-01-01
En el presente paper se trata el tema de la valoración actuarial del nuevo esquema de prestaciones sociales contempladas en la nueva Ley Orgánica del Trabajo de Venezuela . Se desarrolla un modelo actuarial en detalle y se ilustra con un ejemplo numérico el impacto en temas de pasivo actuarial para una empresa típica. Besides the usual pension benefits the pension plan of a company may be forced by law in some countries to offer wage based Lump-sum payments for labor termination this is t...
Herranz Peinado, Patricia
2008-01-01
Full Text Available España ha seguido la tendencia de otros países en cuanto a la cobertura de las personas dependientes, es decir, aquellas que necesitan ayuda para realizar las tareas básicas de la vida diaria, y lo ha hecho mediante la aprobación de la Ley de Promoción de la Autonomía Personal y Atención a las personas en situación de Dependencia, que se basa en la financiación pública. A pesar de los esfuerzos para el desarrollo de la Ley, ésta no está dando los frutos que debiera haber dado y se hace necesaria la existencia de productos privados de cobertura que puedan atender a las necesidades de aquellos que los demandan. Dado los escasos estudios que sobre este tema existen todavía en nuestro país, el establecer una aproximación a las primas de un seguro privado de dependencia puede servir de referencia para el análisis de su comercialización por parte de las aseguradoras. En este trabajo se trata de analizar una serie de cuestiones que den respuesta a dos objetivos. Por una parte, establecer un modelo financiero-actuarial que sirva como apoyo en el diseño de productos privados que cubran la dependencia y, por otra, realizar una aproximación a las bases técnicas actuariales que lleven a la cuantificación de las primas. = Spain has followed the trend of other countries about long term care, that is, people who need help to perform the basic tasks of daily living. In December 2006, Spanish Parliament approved the law called Ley de Promoción de la Autonomía Personal y Atención a las personas en situación de Dependencia, with public financing. This law is not producing the expected results, and it makes necessary the existence of private insurance. Currently, there are few studies on long term care in our country. An approach to premiums of a private insurance can serve as reference for the studies by insurers. This work tries to study a series of questions responding simultaneously to two goals, establishing an actuarial model and, on
Estudio Actuarial de los Fondos de Cesantía 2005
David Bravo; Jaime Ruiz-Tagle V; José Luis Castillo
2007-01-01
El presente documento constituye el informe final del Centro de Microdatos del Departamento de Economía de la Universidad de Chile, que ha desarrollado el estudio actuarial correspondiente al año 2005..
Formulating a stochastic discounting model with actuarial and risk management applications
Constantinos T. Artikis
2012-01-01
Stochastic discounting models are generally recognized as extremely strong analytical tools for a very wide variety of fundamental areas in the actuarial discipline. The paper is mainly devoted to the formulation, investigation and application in the actuarial discipline of a stochastic discounting model. It is shown that the formulated stochastic discounting model can substantially support the role of proactivity in making insurance decisions. JEL Classification: C51 Keywords: Stocha...
Monitoring Actuarial Present Values of Term Life Insurance By a Statistical Process Control Chart
Hafidz Omar, M.
2015-06-01
Tracking performance of life insurance or similar insurance policy using standard statistical process control chart is complex because of many factors. In this work, we present the difficulty in doing so. However, with some modifications of the SPC charting framework, the difficulty can be manageable to the actuaries. So, we propose monitoring a simpler but natural actuarial quantity that is typically found in recursion formulas of reserves, profit testing, as well as present values. We shared some simulation results for the monitoring process. Additionally, some advantages of doing so is discussed.
2010-01-01
... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Actuarial reduction in annuity of retirees who make post-retirement elections to provide a current spouse annuity or a former spouse annuity... Actuarial reduction in annuity of retirees who make post-retirement elections to provide a current...
5 CFR 839.1121 - What is the Actuarial Reduction for the Basic Employee Death Benefit (BEDB)?
2010-01-01
... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false What is the Actuarial Reduction for the... Benefits § 839.1121 What is the Actuarial Reduction for the Basic Employee Death Benefit (BEDB)? If you... employee's death. The result is rounded to the next highest dollar amount and is the monthly...
2011-08-10
...: Background On May 7, 2009, the IRS published in the Federal Register (74 FR 21438 and 74 FR 21519) final and... Use of Actuarial Tables in Valuing Annuities, Interests for Life or Terms of Years, and Remainder or..., and 25 RIN 1545-BH67 Use of Actuarial Tables in Valuing Annuities, Interests for Life or Terms...
26 CFR 1.412(c)(2)-1 - Valuation of plan assets; reasonable actuarial valuation methods.
2010-04-01
... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Valuation of plan assets; reasonable actuarial valuation methods. 1.412(c)(2)-1 Section 1.412(c)(2)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT... Plans, Etc. § 1.412(c)(2)-1 Valuation of plan assets; reasonable actuarial valuation methods....
Applying a Forensic Actuarial Assessment (the Violence Risk Appraisal Guide) to Nonforensic Patients
Harris, Grant T.; Rice, Marnie E.; Camilleri, Joseph A..
2004-01-01
The actuarial Violence Risk Appraisal Guide (VRAG) was developed for male offenders where it has shown excellent replicability in many new forensic samples using officially recorded outcomes. Clinicians also make decisions, however, about the risk of interpersonal violence posed by nonforensic psychiatric patients of both sexes. Could an actuarial…
2011-03-31
... comprehensive amendments to the regulations regarding section 3042 in 1988 (53 FR 34484). In anticipation of... published in the Federal Register on June 30, 2004 (69 FR 39376). On December 21, 2007, the Joint Board... actuary in the Federal Register (72 FR 72606). On September 21, 2009, the Joint Board issued...
Should Actuarial Risk Assessments Be Used with Sex Offenders Who Are Intellectually Disabled?
Harris, Andrew J. R.; Tough, Susan
2004-01-01
Background: Objective actuarial assessments are critical for making risk decisions, determining the necessary level of supervision and intensity of treatment ( Andrews & Bonta 2003). This paper reviews the history of organized risk assessment and discusses some issues in current attitudes towards sexual offenders with intellectual disabilities.…
Smith, Richard Manning; Schumacher, Phyllis
2006-01-01
The authors studied beginning undergraduate actuarial concentrators in a business college. They identified four variables (math Scholastic Aptitude Test [SAT] score, verbal SAT score, percentile rank in high school graduating class, and percentage score on a college mathematics placement exam) that were available for entering college students that…
Sexual Reconviction Rates in the United Kingdom and Actuarial Risk Estimates
Craig, Leam A.; Browne, Kevin D.; Stringer, Ian; Hogue, Todd E.
2008-01-01
Objective: Assessing the risk of further offending behavior by adult sexual perpetrators of children is highly relevant and important to professionals involved in child protection. Recent progress in assessing risk in sexual offenders has established the validity of actuarial measures, although there continues to be some debate about the…
Nociones Básicas de Estadística Actuarial Vida
Fernández Morales, Antonio
2012-01-01
Con esta colección de dípticos se pretende ofrecer al estudiante de Estadística Actuarial Vida una conjunto de herramientas útiles para facilitar su proceso de aprendizaje de esta disciplina académica y profesional.
José Enrique Devesa Carpio
2015-09-01
Full Text Available El trabajo analiza, desde el punto de vista actuarial, la sostenibilidad de la Caja Nacional de Seguridad Social de Marruecos, que es un régimen contributivo que incorpora tanto a trabajadores por cuenta ajena como por cuenta propia. Para ello se llevan a cabo casi 2000 simulaciones, a partir de individuos tipo definidos en función de las peculiaridades del sistema. Además de estudiar la situación actual se analiza el efecto de la reforma que se pretende aplicar al sistema. La conclusión principal es la insostenibilidad actuarial del mismo. The paper analyzes, from the actuarial point of view, the sustainability of the National Social Security Fund in Morocco, which is a contributory scheme that incorporates both employees and self-employed. To do this, almost 2000 simulations are conducted, from different type of individuals defined according to the peculiarities of the system. In addition to studying the current situation, the effect of the reform intended to apply to the system will be analyzed. The main conclusion is the actuarial unsustainability of the system.
2013-02-06
... was published in the Federal Register on January 4, 2013 (78 FR 773). The Hartford-IDS Group is.../ Information Delivery Services (IDS)/Corporate & Financial Reporting Group, Hartford, CT; Notice of Negative... Services Group, Inc., Commercial/Actuarial/Information Delivery Services (IDS)/Corporate &...
Actuarial calculation for PSAK-24 purposes post-employment benefit using market-consistent approach
Effendie, Adhitya Ronnie
2015-12-01
In this paper we use a market-consistent approach to calculate present value of obligation of a companies' post-employment benefit in accordance with PSAK-24 (the Indonesian accounting standard). We set some actuarial assumption such as Indonesian TMI 2011 mortality tables for mortality assumptions, accumulated salary function for wages assumption, a scaled (to mortality) disability assumption and a pre-defined turnover rate for termination assumption. For economic assumption, we use binomial tree method with estimated discount rate as its average movement. In accordance with PSAK-24, the Projected Unit Credit method has been adapted to determine the present value of obligation (actuarial liability), so we use this method with a modification in its discount function.
Alice in actuarial-land: through the looking glass of changing Static-99 norms.
Sreenivasan, Shoba; Weinberger, Linda E; Frances, Allen; Cusworth-Walker, Sarah
2010-01-01
The Static-99, an actuarial rating method, is employed to conduct sexual violence risk assessment in legal contexts. The proponents of the Static-99 dismiss clinical judgment as not empirical. Two elements must be present to apply an actuarial risk model to a specific individual: sample representativeness and uniform measurement of outcome. This review demonstrates that both of these elements are lacking in the normative studies of the Static-99 and its revised version, the Static-99R. Studies conducted since the publication of the Static-99 have not replicated the original norms. Sexual recidivism rates for the same Static-99 score vary widely, from low to high, depending on the sample used. A hypothetical case example is presented to illustrate how the solitary application of the Static-99 or Static-99R recidivism rates to the exclusion of salient clinical factors for identifying sexual dangerousness can have serious consequences for public safety. PMID:20852227
A note on the computation of an actuarial Waring formula in the finite-exchangeable case
Cousin, Areski; Dorobantu, Diana; Rullière, Didier
2011-01-01
We present in this paper the actuarial Waring formula, which is used in several fields, like life-insurance or credit risk. In a particular framework where considered random variables are exchangeable, we show that some problems can occur when using this formula. We propose alternative recursions in order to improve the complexity of the calculations, and to cope with the numerical instability of the formula.
Montserrat Guillen; Jens Perch Nielsen; Catalina Bolance
2000-01-01
In this paper we concentrate on the estimation of loss functions using nonparametric methods. We focus on the parametric transformation approach to kernel smoothing introduced by Wand, Marron and Ruppert (1991) and compare it with the standard kernel estimator and the multiplicative bias correction method (Hjort and Glad, 1995 and Jones, Linton and Nielsen, 1995). We advocate in this paper that the transformation method behaves excellently when it comes to estimating actuarial and financial l...
Fair value: actuarial accounting for the markets... or for the accountants?
Jerman, Lambert
2013-01-01
Fair value accounting under IAS-IFRSs is often presented as market accounting that results from expression of the financial requirements of business management and accounting practice. By showing that fair value has the features of actuarial accounting, and is the product of a conceptual shift made necessary by the contemporary context and thus in dissonance with certain aspects of current accounting practice, this article demonstrates that fair value accounting in fact represents an opportun...
ActuArial Accounting – A Branch of the Financial Accounting
Gheorghe V. Lepadatu; Doina Maria Tilea
2010-01-01
The opening of the accounting to the actuarial calculation is a normal consequence of its evolutive spirit. At the origin of the international accounting standards lies the framework for preparing, presenting and disclosing the financial statements. The framework stays as a reference matrix, as a standard of standards, as a constitution of financial accounting. According to the international framework, the financial statements use different evaluation bases: the historical cost, the current c...
Actuarial modeling of cost of voluntary pension insurance of the population of the region
Mikhailova Svetlana Sergeevna
2013-06-01
Full Text Available In article approach to determination of net value of the contract of pension insurance for the man's and female population, considering regional demographic features is offered. Results of actuarial calculation of the size pure net - rates of individual pension insurance are presented, "sensitivity" of cost of insurance is defined by methods of statistical modeling to key parameters of a pension product for the region population.
El balance actuarial como indicador de la solvencia del sistema de reparto
María del Carmen Boado Penas; Carlos Vidal- Meliá
2008-01-01
The aim of this work is twofold: on the one hand, to demonstrate the utility of the actuarial balance as an element of transparency, an indicator of the solvency, sustainability and financial solidity of the pay-as-you-go system and a tool capable of providing positive incentives to improve the financial management of the system, eliminating or at least reducing the traditional divergence between the planning horizon of the politicians and that of the system itself; and on the other, to make ...
Assink, Mark; van der Put, Claudia E; Stams, Geert Jan J M
2016-05-01
For prevention purposes, it is important that police officers can estimate the risk for delinquency among juveniles who were involved in a criminal offense, but not in the role of a suspect. In the present study, the Youth Actuarial Risk Assessment Tool for First-Time Offending (Y-ARAT-FO) was developed based solely on police records with the aim to enable Dutch police officers to predict the risk for first-time offending. For the construction of this initial screening instrument, an Exhaustive Chi-squared Automatic Interaction Detector (Exhaustive CHAID) analysis was performed on a data set that was retrieved from the Dutch police system. The Y-ARAT-FO was developed on a sample of 1,368 juveniles and validated on a different sample of 886 juveniles showing moderate predictive accuracy in the validation sample (area under the receiver operating characteristic curve [AUC] = .728). The predictive accuracy of the Y-ARAT-FO was considered sufficient to justify its use as an initial screening instrument by the Dutch police. PMID:25395478
PRESTACIONES NO CONTRIBUTIVAS DE INVALIDEZ: EL LÍMITE DE INGRESOS Y LA EQUIVALENCIA ACTUARIAL
Daniel Hernández González
2009-02-01
Full Text Available El límite de ingresos es una herramienta útil para objetivar la carencia de rentas y permitir la obtención de pensiones no contributivas. Sin embargo, su aplicación práctica da lugar a escenarios de escasa justificación técnica o social, por lo que el uso de la equivalencia actuarial sería de gran utilidad para determinar de una forma más adecuada el verdadero estado patrimonial del individuo a lo largo del tiempo y, con ello, la realidad de sus derechos en materia de seguridad social. The limit of earnings is an useful tool to define the lack of income and allow access to a non-contributory pension. However, its practical application promotes scenarios with poor technical or social justification, so the use of actuarial equivalence would be useful to determine adequately the person’s real patrimony in the long term and, thus, the reality of their rights of social security.
THE EVOLUTION AND FUTURE OF SOCIAL SECURITY IN AFRICA: AN ACTUARIAL PERSPECTIVE
Fatima Badat
2015-09-01
Full Text Available Social Security in most African countries has evolved significantly in terms of perspectives, motives, governance as well as innovation of benefits and administration. African countries are slowly, one by one, beginning to reassess the role of social security in correcting several social ills. Empowerment programs and grants are increasingly being provided via social security to women and the youth. From the roots of social security, even very low income countries, some of which have recently experienced several years of civil war and extreme economic hardships, have begun to improve benefit structures and amounts, which include national medical benefits. The attention being provided to social security and how it fits into a nation’s plans to lift itself out of poverty is increasingly involving the actuarial profession from international organisations such as ILO and ISSA as well as consulting actuaries and academics. Assessing and ensuring sustainability of social security benefits requires actuarial valuations to take long-term consequences involving demographic changes into account in the face of providing the benefits in the short term; asset liability modelling to ensure adequate resources are held; ensuring that results are appropriately reported and communicated to key stakeholders; as well as developing long-term strategic plans and dynamic systems surrounding all of these issues. In this paper, the role of actuaries is brought to the centre of the increasingly changing face and evolving culture of social security in taking Africa closer to poverty alleviation. La Seguridad Social en la mayoría de los países africanos ha evolucionado significativamente en cuanto a perspectivas, motivos, gobernanza, así como en innovación en las prestaciones y la adminsitración. Los países africanos están comenzando a reevaluar el papel de la Seguridad Social en la eliminación de determinados problemas sociales. Los programas de acción y los
NEW METHOD TO OPTION PRICING FOR THE GENERAL BLACK-SCHOLES MODEL-AN ACTUARIAL APPROACH
闫海峰; 刘三阳
2003-01-01
Using physical probability measure of price process and the principle of fairpremium, the results of Mogers Bladt and Hina Hviid Rydberg are generalized. In twocases of paying intermediate divisends and no intermediate dividends, the Black-Scholesmodel is generalized to the case where the risk-less asset (bond or bank account) earns atime-dependent interest rate and risk asset (stock) has time-dependent the continuouslycompounding expected rate of return, volatility. In these cases the accurate pricing formulaand put- call parity of European option are obtained. The general approach of option pricingis given for the general Black-Scholes of the risk asset (stock) has the continuouslycompounding expected rate of return, volatility. The accurate pricing formula and put- callparity of European option on a stock whose price process is driven by general Ornstein-Uhlenback (O-U) process are given by actuarial approach.
Optimization of Actuarial Model for Individual Account of Rural Social Pension Insurance
Wenxian; CAO
2013-01-01
This paper firstly analyzes different payment methods of individual account and the pension replacement rate under the pension payment method.Results show that it will be more scientific and reasonable for the individual account of new rural social pension insurance to adopt the actuarial model of payment according to proportion of income and periodic prestation at variable amount.The Guiding Opinions on New Rural Social Pension Insurance sets forth individual account should be paid at fixed amount,and the insured voluntarily selects payment level as per criteria set by the State.The monthly calculation and distribution amount of pension is the total amount of individual account divided by139.Therefore,it should start from continuation of policies and make adjustment of payment level in accordance with growth of per capita net income of rural residents.When condition permits,it is expected to realize transition to payment as per income proportion and periodic prestation at variable amount.
Xian-min Geng; Shu-chen Wan
2011-01-01
The compound negative binomial model, introduced in this paper, is a discrete time version. We discuss the Markov properties of the surplus process, and study the ruin probability and the joint distributions of actuarial random vectors in this model. By the strong Markov property and the mass function of a defective renewal sequence, we obtain the explicit expressions of the ruin probability, the finite-horizon ruin probability,the joint distributions of T, U(T - 1), |U(T)| and inf 0≤n＜T1 U(n) (i.e., the time of ruin, the surplus immediately before ruin, the deficit at ruin and maximal deficit from ruin to recovery) and the distributions of some actuariai random vectors.
Reproductive effort accelerates actuarial senescence in wild birds: an experimental study.
Boonekamp, Jelle J; Salomons, Martijn; Bouwhuis, Sandra; Dijkstra, Cor; Verhulst, Simon
2014-05-01
Optimality theories of ageing predict that the balance between reproductive effort and somatic maintenance determines the rate of ageing. Laboratory studies find that increased reproductive effort shortens lifespan, but through increased short-term mortality rather than ageing. In contrast, high fecundity in early life is associated with accelerated senescence in free-living vertebrates, but these studies are non-experimental. We performed lifelong brood size manipulation in free-living jackdaws. Actuarial senescence--the increase in mortality rate with age--was threefold higher in birds rearing enlarged- compared to reduced broods, confirming a key prediction of the optimality theory of ageing. Our findings contrast with the results of single-year brood size manipulation studies carried out in many species, in which there was no overall discernible manipulation effect on mortality. We suggest that our and previous findings are in agreement with predictions based on the reliability theory of ageing and propose further tests of this proposition. PMID:24818237
Hilton, N. Zoe; Harris, Grant T.; Rice, Marnie E.; Lang, Carol; Cormier, Catherine A.; Lines, Kathryn J.
2004-01-01
An actuarial assessment to predict male-to-female marital violence was constructed from a pool of potential predictors in a sample of 589 offenders identified in police records and followed up for an average of almost 5 years. Archival information in several domains (offender characteristics, domestic violence history, nondomestic criminal…
If You Build It, Will They Come? Tales of Developing a New Degree Program in Actuarial Science
Marano, Lisa E.
2014-01-01
In 2007, the B.S. in Applied Mathematics program consisting of five concentrations, including Actuarial Science, began at West Chester University of Pennsylvania, and we graduated our first class (of one) that December. We describe our program, some ideas to consider when planning your own program, and share some of the successes of our program…
2013-02-12
... in the valuation of benefits under DoD retiree health care programs for Medicare-eligible beneficiaries. Agenda 1. Meeting Objective a. Review of FY 2014 per capita full-time and part-time normal cost... Retiree Health Care Fund Update 4. September 30, 2011 Actuarial Valuation Results 5. September 30,...
Cunningham, Mark D.; Sorensen, Jon R.
2006-01-01
An investigation and extension of the Risk Assessment Scale for Prison (RASP-Potosi), an actuarially derived scale for the assessment of prison violence, was undertaken through a retrospective review of the disciplinary records of the first 12 months of confinement of a cohort of inmates entering the Florida Department of Corrections in 2002 and…
Age, actuarial risk, and long-term recidivism in a national sample of sex offenders.
Nicholaichuk, Terry P; Olver, Mark E; Gu, Deqiang; Wong, Stephen C P
2014-10-01
Age at release has become an increasing focus of study with regard to evaluating risk in the sex offender population and has been repeatedly shown to be an important component of the risk assessment equation. This study constitutes an extension of a study of sex offender outcomes prepared for the Evaluation Branch, Correctional Service of Canada. The entire cohort of 2,401 male federally incarcerated sexual offenders who reached their warrant expiry date (WED) within 1997/1998, 1998/1999, and 1999/2000 fiscal years were reviewed for the study. Sexual and violent reconviction information was obtained from CPIC criminal records over an average of 12.0 years (SD = 1.7) follow-up. This study focused upon the cohort of sex offenders who were 50 years or older at time of release (N = 542). They were stratified according to risk using a brief actuarial scale (BARS) comprising six binary variables. For the most part, older offenders showed low base rates of sexual recidivism regardless of the risk band into which they fell. The exception was a small group of elderly offenders (n = 20) who fell into the highest risk band, and who showed high levels of sexual recidivism. The results of this combination of cross-sectional and longitudinal analyses of elderly sexual offenders may have important implications for offender management, particularly in light of the increasing numbers of offenders in Canada who fall into the over 50 age cohort. PMID:23818657
Långström, Niklas
2004-04-01
Little is known about whether the accuracy of tools for assessment of sexual offender recidivism risk holds across ethnic minority offenders. I investigated the predictive validity across ethnicity for the RRASOR and the Static-99 actuarial risk assessment procedures in a national cohort of all adult male sex offenders released from prison in Sweden 1993-1997. Subjects ordered out of Sweden upon release from prison were excluded and remaining subjects (N = 1303) divided into three subgroups based on citizenship. Eighty-three percent of the subjects were of Nordic ethnicity, and non-Nordic citizens were either of non-Nordic European (n = 49, hereafter called European) or African Asian descent (n = 128). The two tools were equally accurate among Nordic and European sexual offenders for the prediction of any sexual and any violent nonsexual recidivism. In contrast, neither measure could differentiate African Asian sexual or violent recidivists from nonrecidivists. Compared to European offenders, AfricanAsian offenders had more often sexually victimized a nonrelative or stranger, had higher Static-99 scores, were younger, more often single, and more often homeless. The results require replication, but suggest that the promising predictive validity seen with some risk assessment tools may not generalize across offender ethnicity or migration status. More speculatively, different risk factors or causal chains might be involved in the development or persistence of offending among minority or immigrant sexual abusers. PMID:15208896
Ricote Gil, Fernando.
2003-01-01
Full Text Available La dependencia es un estado en el que se encuentran las personas que por razones ligadas a la falta o la pérdida de autonomía física, psíquica o intelectual tienen necesidad de asistencia y/o atención significativa para la realización los actos corrientes de la vida diaria. Dentro de la iniciativa privada, el sector asegurador juega un importante papel para la prestación de garantías derivadas de esta cobertura. Un aspecto fundamental en el estudio de esta cobertura es la consideración de los periodos de carencia y el tratamiento del contraseguro de primas durante los mismo. Se analiza el riesgo actuarial y su tratamiento en esta cobertura y la incidencia en la valoración actuarial de las primas por prestaciones de dependencia.
Luis Rojas-Torres
2014-09-01
Full Text Available This paper summarizes a study conducted in 2013 with the purpose of predicting the failure rate of math courses taken by Pharmacy, Mathematics, Actuarial Science, Physics and Meteorology students at Universidad de Costa Rica (UCR. Using the Logistics Regression statistical techniques applied to the 2010 cohort, failure rates were predicted of students in the aforementioned programs in one of their Math introductory courses (Calculus 101 for Physics and Meteorology, Math Principles for Mathematics and Actuarial Science and Applied Differential Equations for Pharmacy. For these models, the UCR admission average, the student’s genre, and the average correct answers in the Quantitative Skills Test were used as predictor variables. The most important variable for all models was the Quantitative Skills Test, and the model with the highest correct classification rate was the Logistics Regression. For the estimated Physics-Meteorology, Pharmacy and Mathematics-Actuarial Science models, correct classifications were 89.8%, 73.6%, and 93.9%, respectively.
LA ESCALA DE PORCENTAJES DE LA LEY 27/2011: UN ENFOQUE ACTUARIAL PARA UN NUEVO MODELO SOSTENIBLE
Pedro Javier Budia Aldana
2014-05-01
Full Text Available La Ley 27/2011, de 1 de agosto, sobre actualización, adecuación y modernización del sistema de seguridad social, ha variado la escala de porcentajes aplicables a la base reguladora en función del número de años cotizados. Los nuevos porcentajes afectan a los trabajadores que se vayan a jubilar con periodos de cotización entre 15 y 37 años y, especialmente, a aquellos trabajadores cuyas pensiones sean bajas y puedan ser beneficiarios de complemento a mínimos. Estas variaciones, que se han ido produciendo en la escala de porcentajes a través de sucesivos cambios legislativos, han llevado al actuario a estudiar cuáles serían los porcentajes de equilibrio financiero-actuarial según el número de años cotizados y la edad de inicio en el mercado laboral para cubrir todas las pensiones que pueda causar el trabajador. The Law 27/2011 of 1 August, about updating, improvement and modernization of the social security system has changed the scale of percentages applicable to the regulatory base depending on the number of years of contributions. The new rates affect workers who are to retire on contribution periods between 15 and 37 years, and especially to those workers whose pensions are low and can receive minimum supplements. These variations, that have they occurred in the percentage scale through successive legislative changes, have led to the actuary to study what percentage of financial and actuarial balance would be according to the number of years of contributions and the age of onset in the labor market to cover all pensions that may cause the worker.
Martin Rettenberger; Reinhard Eher
2006-01-01
The Static-99 and the RRASOR are actuarial risk assessment tools for evaluating the risk of sexual and violent recidivism in sexual offenders. The Static-99 was developed in 1999 by Karl R. Hanson (Canada) and David Thornton (Great Britain) and is in the mean time regularly used for risk assessment in North America and some countries in Europe. The RRASOR can be described as a predecessor of the Static-99 and was published by Hanson in 1997. At first we translated the revised version of the S...
Wollert, Richard; Cramer, Elliot; Waggoner, Jacqueline; Skelton, Alex; Vess, James
2010-12-01
A useful understanding of the relationship between age, actuarial scores, and sexual recidivism can be obtained by comparing the entries in equivalent cells from "age-stratified" actuarial tables. This article reports the compilation of the first multisample age-stratified table of sexual recidivism rates, referred to as the "multisample age-stratified table of sexual recidivism rates (MATS-1)," from recent research on Static-99 and another actuarial known as the Automated Sexual Recidivism Scale. The MATS-1 validates the "age invariance effect" that the risk of sexual recidivism declines with advancing age and shows that age-restricted tables underestimate risk for younger offenders and overestimate risk for older offenders. Based on data from more than 9,000 sex offenders, our conclusion is that evaluators should report recidivism estimates from age-stratified tables when they are assessing sexual recidivism risk, particularly when evaluating the aging sex offender. PMID:21098823
Antonio Fernández Morales
2010-12-01
Full Text Available En este artículo se describe el diseño y los resultados obtenidos con una estrategia didáctica innovadora para el aprendizaje de la Estadística Actuarial en la licenciatura de Ciencias Actuariales y Financieras de la Universidad de Málaga. Mediante un uso intensivo de actividades no presenciales y elementos tecnológicos que favorecen el aprendizaje en movilidad se pretende potenciar el aprendizaje autónomo, colaborativo y contextualizado. Para ello se han diseñado, entre otras, actividades de identificación y asimilación de competencias, un laboratorio virtual de supervivencia basado en un simulador gráfico interactivo y un microportal para dispositivos iPhone y iPod touch de Apple.
Tablas de mortalidad dinámicas con hoja de cálculo en la práctica actuarial
Fernández Morales, Antonio
2015-01-01
En este trabajo se presenta la aplicación de procedimientos de obtención de probabilidades de fallecimiento, mediante hoja de cálculo, para generaciones y años de calendario futuros, basadas en la información contenida en tablas de mortalidad dinámicas, desde el punto de vista actuarial.
Looman, Jan; Abracen, Jeffrey
2011-01-01
There has been relatively little research on the degree to which measures of lifetime history of substance abuse add to the prediction of risk based on actuarial measures alone among sexual offenders. This issue is of relevance in that a history of substance abuse is related to relapse to substance using behavior. Furthermore, substance use has…
Sixty-Six Years of Research on the Clinical Versus Actuarial Prediction of Violence
Hilton, N. Zoe; Harris, Grant T.; Rice, Marnie E.
2006-01-01
In their meta-analysis of clinical versus statistical prediction models, Aegisdottir et al. (this issue) extended previous findings of statistical-method superiority across such variables as clinicians' experience and familiarity with data. In this reaction, the authors are particularly interested in violence prediction, which yields the greatest…
An Actuarial Model for Assessment of Prison Violence Risk Among Maximum Security Inmates
Cunningham, Mark D.; Sorensen, Jon R.; Reidy, Thomas J.
2005-01-01
An experimental scale for the assessment of prison violence risk among maximum security inmates was developed from a logistic regression analysis involving inmates serving parole-eligible terms of varying length (n = 1,503), life-without-parole inmates (n = 960), and death-sentenced inmates who were mainstreamed into the general prison population…
Hammitt, James K; Ibarrarán, María Eugenia
2006-12-01
Compensating wage differentials are used to estimate marginal rates of substitution between income and both fatal and non-fatal occupational-injury risks in the Mexico City metropolitan area. Data are obtained by in-person survey of almost 600 workers and include workers' perceived risks of fatal and non-fatal occupational injury supplemented by actuarial-risk estimates from government statistics. Results using both actuarial- and perceived-risk estimates are reasonably consistent. Estimates of the value per statistical life are between 235,000 US dollars and 325,000 US dollars and estimates of the value per statistical non-fatal injury are between 3500 US dollars and 11,000 US dollars (2002 US dollars). These values are much smaller than corresponding estimates for higher-income countries but are compatible with the small number of prior estimates for lower-income countries. PMID:16929475
Luis Eduardo Giron
2015-12-01
Full Text Available La presente investigación pretende calcular y comparar la prima de un reaseguro usando el modelo de opciones de Black-Scholes y el modelo clásico actuarial tradicional. El período de análisis va desde enero de 2011 hasta diciembre de 2012. Los resultados obtenidos muestran que el modelo de Black-Scholes, que se utiliza normalmente para valorar opciones financieras, puede ser también usado para la estimación de primas de reaseguros de salud; y que la prima neta estimada a partir de este modelo se aproxima a las establecidas por el método actuarial, excepto cuando el deducible del reaseguro es muy alto (por encima de $200.000.000.
Martin Rettenberger
2006-12-01
Full Text Available The Static-99 and the RRASOR are actuarial risk assessment tools for evaluating the risk of sexual and violent recidivism in sexual offenders. The Static-99 was developed in 1999 by Karl R. Hanson (Canada and David Thornton (Great Britain and is in the mean time regularly used for risk assessment in North America and some countries in Europe. The RRASOR can be described as a predecessor of the Static-99 and was published by Hanson in 1997. At first we translated the revised version of the Static-99 (Harris, Phenix, Hanson & Thornton, 2003 and adapted the instrument and the manual to the forensic context in Germany and Austria (Rettenberger & Eher, 2006. In this retrospective study, interrater reliability and concurrent validity of the RRASOR and of the German adaption of the Static-99 is presented. Furthermore we evaluated the predictive accuracy of the Static-99 and the RRASOR and compared their results. The instruments were validated from file information of Austrian sexuel offenders, who were convicted between 1968 and 2002. Both the Static-99 and the RRASOR had good interrater reliability and concurrent validity. The Static-99 showed good predictive validity for general (r = .41, AUC = .74, sexual (r = .35, AUC = .74 and violent (r = .41, AUC = .76 recidivism, whereas the predictive accuracy of the RRASOR was moderate for general (r = .29, AUC = .66, sexual (r = .30, AUC = .68 and violent (r = .28, AUC = .67 recidivism. The Static-99 exhibited a higher accuracy for the prediction of sexual offender recidivism. Although further validation studies on German-speaking populations of sex offenders are necessary, these results support the utility of the German version of the revised version of the Static-99 in improving risk assessment of sexual offenders.
Resultados económicos de la gestión de los planes y fondos de pensiones: La ganancia actuarial
García González, A.; Peláez Fermoso, F. J.
1998-01-01
Uno de los objetivos que persigue el gestor de un plan de pensiones de prestación definida como el analizado en este artículo, al utilizar los métodos de valoración actuarial para la determinación del coste anual del mismo, es comprobar que los recursos financieros del fondo en cada momento de su valoración sean los adecuados para hacer frente al pago de los compromisos que respecto a los beneficiarios tiene asumido el plan. Sin embargo, este fondo no siempre es capaz de garantizar estos...
Olver, Mark E; Nicholaichuk, Terry P; Gu, Deqiang; Wong, Stephen C P
2013-08-01
The present study is an examination of sex offender treatment outcome in a large national cohort of Canadian Federally incarcerated sex offenders followed up an average of 11.7 years postrelease. A brief actuarial risk scale (BARS), which predicted sexual and violent recidivism, was created for the purposes of the present study to control for risk-related differences between treated and untreated offenders. In total, 732 offenders were identified as having completed (n = 625) or not attended (n = 107) a sex offender treatment program and for whom sufficient information was available to complete the scale. Controlling for risk and individual differences in follow-up time using Cox regression survival analyses and an 8-year fixed follow-up period, treated sex offenders demonstrated significantly lower rates of violent, but not sexual, recidivism. When the treated and untreated groups were stratified by risk level, significant differences were observed only among moderate or high risk offenders. Some significant group differences also emerged on indicators of recidivism severity, with treated offenders demonstrating slower times to sexual reoffense and lower scores on a quantified metric of sexual and violent recidivism severity after controlling for risk. Differences in recidivism base rates between treated and untreated offenders were also larger in magnitude for younger offenders (i.e., under age 50 at release), than for older offenders; however, interactions between age and treatment were not found. The findings are consistent with the risk principle and have possible implications regarding the dynamic nature of sexual violence risk. PMID:23136142
Mª Manuela Segovia
2005-01-01
Full Text Available En los países industrializados, convergen dos fenómenos demográficos, la longevidad y la escasa natalidad, que provocan un envejecimiento de la población y con ello una serie de procesos sociales que son necesarios atender. Uno de ellos, es la cobertura de la dependencia de las personas mayores, entendiendo por dependencia, la necesidad de ayuda para realizar las tareas básicas de la vida diaria. España se encuentra en la actualidad en plena discusión parlamentaria para regular mediante ley la dependencia y cubrir el avance de este problema que en los próximos años se verá agravado por nuestra evolución demográfica y social. Esta ley pretende establecer las bases para su atención mediante un seguro de dependencia, bien de cobertura pública por parte del Estado o bien por aseguradoras privadas. El trabajo presentado en este congreso forma parte de un estudio amplio sobre la dependencia en España y abordará una aproximación a la formulación actuarial de un seguro de dependencia partiendo del uso de cadenas de Markov para un modelo de múltiples estados, y un acercamiento a la aplicación práctica mediante el análisis de datos sobre discapacidad de nuestro país.
Essaky, El; Vives, Josep
2016-01-01
This book is the outcome of the CIMPA School on Statistical Methods and Applications in Insurance and Finance, held in Marrakech and Kelaat M'gouna (Morocco) in April 2013. It presents two lectures and seven refereed papers from the school, offering the reader important insights into key topics. The first of the lectures, by Frederic Viens, addresses risk management via hedging in discrete and continuous time, while the second, by Boualem Djehiche, reviews statistical estimation methods applied to life and disability insurance. The refereed papers offer diverse perspectives and extensive discussions on subjects including optimal control, financial modeling using stochastic differential equations, pricing and hedging of financial derivatives, and sensitivity analysis. Each chapter of the volume includes a comprehensive bibliography to promote further research.
Kim, JeongYeon
2014-01-01
This study reviews new pension accounting with K-IFRS and provides empirical changes in liability for retirement allowances with adoption of K-IFRS. It will help to understand the effect of pension accounting on individual firm's financial report and the importance of public announcement of actuarial assumptions. Firms that adopted K-IFRS had various changes in retirement liability compared to the previous financial report not based on K-IFRS. Their actuarial assumptions for pension accounting should be announced, but only few of them were published. Data analysis shows that the small differences of the actuarial assumption may result in a big change of retirement related liability. Firms within IT industry also have similar behaviors, which means that additional financial regulations for pension accounting are recommended. PMID:25013868
JeongYeon Kim
2014-01-01
Full Text Available This study reviews new pension accounting with K-IFRS and provides empirical changes in liability for retirement allowances with adoption of K-IFRS. It will help to understand the effect of pension accounting on individual firm’s financial report and the importance of public announcement of actuarial assumptions. Firms that adopted K-IFRS had various changes in retirement liability compared to the previous financial report not based on K-IFRS. Their actuarial assumptions for pension accounting should be announced, but only few of them were published. Data analysis shows that the small differences of the actuarial assumption may result in a big change of retirement related liability. Firms within IT industry also have similar behaviors, which means that additional financial regulations for pension accounting are recommended.
Life insurance theory actuarial perspectives
Vylder, F Etienne
1997-01-01
This book is different from all other books on Life Insurance by at least one of the following characteristics 1-4. 1. The treatment of life insurances at three different levels: time-capital, present value and price level. We call time-capital any distribution of a capital over time: (*) is the time-capital with amounts Cl, ~, ... , C at moments Tl, T , ..• , T resp. N 2 N For instance, let (x) be a life at instant 0 with future lifetime X. Then the whole oO oO life insurance A is the time-capital (I,X). The whole life annuity ä is the x x time-capital (1,0) + (1,1) + (1,2) + ... + (I,'X), where 'X is the integer part ofX. The present value at 0 of time-capital (*) is the random variable T1 T TN Cl V + ~ v , + ... + CNV . (**) In particular, the present value ofA 00 and ä 00 is x x 0 0 2 A = ~ and ä = 1 + v + v + ... + v'X resp. x x The price (or premium) of a time-capital is the expectation of its present value. In particular, the price ofA 00 and äx 00 is x 2 A = E(~) and ä = E(I + v + v + ... + v'X...
How Fair Is Actuarial Fairness?
Landes, Xavier
2015-01-01
Insurance is pervasive in many social settings. As a cooperative device based on risk pooling, it serves to attenuate the adverse consequences of various risks (health, unemployment, natural catastrophes and so forth) by offering policyholders coverage against the losses implied by adverse events...
随机利率下的反向抵押贷款精算定价模型研究%Actuarial Pricing Models of Reverse Mortgage with the Stochastic Interest Rate
贾念念; 赵雪; 杨文荟
2015-01-01
反向抵押贷款是应对养老问题的一个创新模式。本文为改进传统反向抵押贷款定价模型必须建立在固定利率基础之上的缺点，利用Wiener过程和负二项分布对利息力积累函数进行联合建模，构建了随机利率下的反向抵押贷款精算定价模型及死亡均匀分布（UDD）假设下随机利率反向抵押贷款精算定价模型。最后，本文运用Matlab软件对随机利率下精算定价模型进行数值测算，比较了不同参数的变化对贷款额的影响程度，得到随机利率下的反向抵押贷款精算定价模型对借款人具有一定的吸引力、贷款利率较房产价值年均升值率和房产折旧率更敏感、递增年金模型受贷款利率变动影响较小等结论。上述结论为我国反向抵押贷款的政策制定与定价提供了一定的理论依据。%The reverse mortgage is a creative measure to support the aged people. for improving shortcomings that the traditional reverse mortgage loan pricing model must be established on the basis of fixed interest rate, this paper builds the united model of accumulation function of interest force by process and negative-binomial distribution, and constructs reverse mortgages actuarial pricing model under the stochastic interest rate and the stochastic interest rate reverse actuarial pricing model under UDD assumption. Finally, this paper uses the Matlab software to change different parameters of actuarial pricing model under stochastic interest rate influence on the degree of the loan, it is concluded that the conclusion of the model is in line with the actual situation, therefore, it has important practical significance to study stochastic interest rate reverse mortgage loan pricing model.
Tutorial: survival analysis--a statistic for clinical, efficacy, and theoretical applications.
Gruber, F A
1999-04-01
Current demands for increased research attention to therapeutic efficacy, efficiency, and also for improved developmental models call for analysis of longitudinal outcome data. Statistical treatment of longitudinal speech and language data is difficult, but there is a family of statistical techniques in common use in medicine, actuarial science, manufacturing, and sociology that has not been used in speech or language research. Survival analysis is introduced as a method that avoids many of the statistical problems of other techniques because it treats time as the outcome. In survival analysis, probabilities are calculated not just for groups but also for individuals in a group. This is a major advantage for clinical work. This paper provides a basic introduction to nonparametric and semiparametric survival analysis using speech outcomes as examples. A brief discussion of potential conflicts between actuarial analysis and clinical intuition is also provided. PMID:10229458
Luis María Sáez de Jáuregui Sanz
2016-06-01
Full Text Available En este trabajo se analizan y se contextualizan los aspectos de índole actuarial y de seguridad social recogidos en la Ley 35/2015 de reforma del sistema para la valoración de los daños y perjuicios causados a las personas en accidentes de circulación. Los preliminares de la Ley 35/2015 comienzan en 2011 con la creación de una Comisión de Expertos. A partir de ahí, se inicia un proceso que culmina, en primer lugar, en 2014 en Junta Consultiva de Seguros y Fondos de Pensiones con la entrega de un Texto articulado, unas Tablas de indemnización y unas Bases técnicas actuariales que configuran un nuevo y novedoso sistema de valoración y que termina de finalizar –tras su trámite parlamentario con prácticamente nulas modificaciones en lo fundamental– con la entrada en vigor el 1 de enero de 2016 de la Ley 35/2015, recogiéndose por primera vez en el ordenamiento jurídico español un modelo actuarial para indemnizar el lucro cesante y el daño emergente. This paper analyzes and contextualizes the actuarial and social security features of the brand new Law 35/2015 of reform for assessing the damage caused to people in road accidents. Preliminaries of the Law 35/2015 began in 2011 with the creation of a Committee of Experts. From there, a process, culminated first in 2014, in the Advisory Board of Insurance and Pension Funds with the delivery of an articulated text, tables compensation and the actuarial technical bases that form a new and novel assessment system, and ended -after the end of its parliamentary process with virtually no changes in fundamentally- with the entry into force, on January 1st of 2016, of the Law 35/2015, introducing for the first time in the Spanish legal system an actuarial model to compensate people for loss of profits and its consequential damages.
Life Insurance Actuarial Model with Returnable Premium
YanhuaiLang
2004-01-01
Insurance is the important aspect of finance. It has been fully developed in the western developed countries. With the fast development of market economy in our country,it is necessary to introduce the alien modern theories and techniques, and at the same time,adapt them to our concrete situation. The model of general life insurance product is to be established in this paper, including deferred life annuities, increasing whole life insurance and returnable premiums. Then through the regulation of various parameters, we can obtain various insurance products.
Selecting Economic Immigrants: An Actuarial Approach
McHale, John; Rogers, Keith
2009-01-01
There is growing international interest in a Canadian-style points system for selecting economic immigrants. Although existing points systems have been influenced by the human capital literature, the findings have traditionally been incorporated in an ad hoc way. This paper explores a formal method for designing a points system based on a human capital earnings regression for predicting immigrant economic success. The method is implemented for Canada using the IMDB, a remarkable longitudinal ...
A Quasi Actuarial Prospect for Individual Assessment.
Owens, William A.
A conceptual model of individual assessment through the use of biodata responses with minimal input information is outlined. The process is considered especially applicable to industrial psychology. A scored autobiographical data form, which measures the individual's past behavior and experiences, provides for assignment to a specific subgroup…
MOACIR A. BORGES
1999-09-01
Full Text Available PROPOSTA: Determinar a idade em que surgem e desaparecem as pontas rolândicas (PR em traçados eletrencefalográficos de rotina. MÉTODO: Estudo prospectivo hospitalar, baseado em 412 eletrencefalogramas de 160 crianças que frequentaram o ambulatório de neuropediatria entre as idades de 1 e 16 anos, no período de março de 1989, a março de 1998. Usou-se o sistema 10/20 para colocação dos eletrodos. As crianças foram dividas, por idade, em quatro grupos (1 a 4; 5 a 8; 9 a 16; 1 a 16 e usou-se o método de curva atuarial, considerando-se como evento, o desaparecimento da PR. RESULTADOS: PR teve distribuição entre meninos e meninas na razão de 64/36. A idade média em que surgiu a PR foi 7 anos (7,2 para homens e 6,6 para mulheres e, num pequeno grupo de crianças que tinha EEG normal anterior ao surgimento da PR, a idade média foi 6,8 anos. Após 7 anos de seguimento, a percentagem de pacientes livres de PRs era 60% para o grupo de 1 a 4 anos na admissão, 84% para os grupos de 5 a 8 anos e 9 a 16 anos. Para o grupo total (1 a 16 anos a percentagem de livres de PR, após 7 anos de seguimento, foi 78%. CONCLUSÃO: O estudo mostra que as PR surgiram, em média, aos 7 anos e têm probabilidade de desaparecimento até 7 anos de seguimento, independetemente da faixa etária de aparecimento.This study aims to determine the age at which the rolandic spikes (RS appear and disappear in routine EEGs. METHOD: It has been carried out a hospital based prospective study of 412 EEGs records of 160 children who had been assisted at the neuropediatric out-patient department during the period between March, 1989 and March,1998. Recordings were made on 8-channel instruments and 10/20 system has been to place the electrodes. The children have been divided into 4 groups, according to their age (1 to 4; 5 to 8; 9 to 16; 1 to 16, and the actuarial curve method has been used to show the disappearance of the rolandic spikes. RESULTS: RS distribution between
Purpose: In general late side-effects after prostate cancer radiotherapy are presented by the use of actuarial incidence rates. The aim of this analysis was to describe additional relevant aspects of late side effects after prostate cancer radiotherapy. Materials and methods: All 178 primary prostate-cancer patients were treated within the Austrian–German multicenter trial by three-dimensional radiotherapy up to a local dose of 70 Gy (low/intermediate-risk) or 74 Gy (high-risk), respectively. Late gastrointestinal/urogenital (GI/GU) side-effects were prospectively assessed by the use of EORTC/RTOG score. Maximum side-effects, actuarial incidence rate and prevalence rates, initial appearance and duration of ⩾grade 2 toxicity were evaluated. Results: Median follow-up was 74 months. Late GI/GU side-effects ⩾grade 2 were detected in 15% (27/178) and 22% (40/178). The corresponding 5-year actuarial incidence rates for GI/GU side-effects were 19% and 23%, whereas the prevalence was 1–2% and 2–7% after 5 years, respectively. Late side effects ⩾grade 2 appeared within 5 years after radiotherapy in all patients with GI side-effects (27/27) and in 85% (34/40) of the patients with GU side-effects, respectively and lasted for less than 3 years in 90% (GI) and 98% (GU). Conclusions: This study demonstrates that the majority of late GI and GU side effects after primary external beam radiotherapy for prostate cancer are transient. Using only actuarial incidence rates for reporting side effects may lead to misinterpretation or overestimation. The combination of incidence and prevalence rates provides a more comprehensive view on the complex issue of late side effects.
External beam irradiation of craniopharyngiomas: long-term analysis of tumor control and morbidity
Purpose: To delineate the long-term control and morbidity with external beam radiotherapy (EBRT) of craniopharyngiomas. Methods and Materials: Between 1971 and 1992, 24 craniopharyngioma patients underwent EBRT at the University of Pittsburgh. Most (19 of 24) were treated within 1-3 months after subtotal resection. The other prior surgical procedures were biopsy (n = 2) and gross total resection (n = 1); 2 patients did not undergo any surgical procedure. The median follow-up was 12.1 years. The median patient age was 29 years (range 5-69). The total radiation doses varied from 36 to 70 Gy (median 59.75). The normalized total dose (NTD, biologically equivalent dose given in 2 Gy/fraction [α/β ratio = 2]) varied from 28 to 83 Gy (median 55.35). Results: The actuarial survival rate at 10 and 20 years was 100% and 92.3%, respectively. The actuarial local control rate at 10 and 20 years was 89.1% and 54.0%, respectively. No local failures occurred with doses ≥60 Gy (n=12) or NTDs ≥55 Gy. The complication-free survival rate at 10 and 20 years was 80.1% and 72.1%, respectively. No complications were noted with an NTD of ≤55 Gy. The actuarial survival free from any adverse outcome (recurrence or complication) was 70.1% and 31.8% at 10 and 20 years, respectively. The adverse outcome-free survival appeared optimized (at 73%) with an NTD of 55-63 Gy. Multivariate analysis found that tumor control correlated significantly with the total dose (p=0.02), treatment complications with NTD (p=0.008), and adverse outcome with hypopituitarism on presentation (p=0.03). Conclusion: We recommend treating craniopharyngioma with 1.6-1.7-Gy dose fractions to 60 Gy to optimize outcome from EBRT
Purpose: This retrospective analysis aims to report results of patients with cervix cancer treated by external beam radiotherapy (EBR) and high-dose-rate (HDR) brachytherapy. Methods and Materials: From September 1992 to December 1996, 138 patients with FIGO Stages II and III and mean age of 56 years were treated. Median EBR to the whole pelvis was 45 Gy in 25 fractions. Parametrial boost was performed in 93% of patients, with a median dose of 14.4 Gy. Brachytherapy with HDR was performed during EBR or following its completion with a dose of 24 Gy in four weekly fractions of 6 Gy to point A. Median overall treatment time was of 60 days. Patient age, tumor stage, and overall treatment time were variables analyzed for survival and local control. Cumulative biologic effective dose (BED) at rectal and bladder reference points were correlated with late complications in these organs and dose of EBR at parametrium was correlated with small bowel complications. Results: Median follow-up time was 38 months. Overall survival, disease-free survival, and local control at 5 years was 53.7%, 52.7%, and 62%, respectively. By multivariate and univariate analysis, overall treatment time up to 50 days was the only statistically significant adverse variable for overall survival (p=0.003) and actuarial local control (p=0.008). The 5-year actuarial incidence of rectal, bladder, and small bowel late complications was 16%, 11%, and 14%, respectively. Patients treated with cumulative BED at rectum points above 110 Gy3 and at bladder point above 125 Gy3 had a higher but not statistically significant 5-year actuarial rate of complications at these organs (18% vs. 12%, p=0.49 and 17% vs. 9%, p=0.20, respectively). Patients who received parametrial doses larger than 59 Gy had a higher 5-year actuarial rate of complications in the small bowel; however, this was not statistically significant (19% vs. 10%, p=0.260). Conclusion: This series suggests that 45 Gy to the whole pelvis combined with
Introduction to modeling and analysis of stochastic systems
Kulkarni, V G
2011-01-01
This is an introductory-level text on stochastic modeling. It is suited for undergraduate students in engineering, operations research, statistics, mathematics, actuarial science, business management, computer science, and public policy. It employs a large number of examples to teach the students to use stochastic models of real-life systems to predict their performance, and use this analysis to design better systems. The book is devoted to the study of important classes of stochastic processes: discrete and continuous time Markov processes, Poisson processes, renewal and regenerative processes, semi-Markov processes, queueing models, and diffusion processes. The book systematically studies the short-term and the long-term behavior, cost/reward models, and first passage times. All the material is illustrated with many examples, and case studies. The book provides a concise review of probability in the appendix. The book emphasizes numerical answers to the problems. A collection of MATLAB programs to accompany...
Quants at the Gate: The Unique Education of Actuaries
Halfond, Jay A.; Horwitz, Lois K.
2012-01-01
An academic discipline and a profession eventually converge through the relationship, division of labor and trust between universities and professional associations--and their mutual respect for the authority and the respective roles of one another. Sometimes, professional associations evaluate academic programs or even provide an examination at…
The Evolution of an Undergraduate Actuarial Mathematics Program
Kennedy, Kristin; Schumacher, Phyllis
2014-01-01
Bryant University was originally a school for business majors and offered only a few mathematics courses. After becoming accredited by the New England Association of Colleges and Universities in the 1960s, the college was required to upgrade its offerings in the area of mathematics. In the 1970s, the department offerings were increased to include…
The Actuarial Turn in the Science of Learning Disabilities
Danforth, Scot
2011-01-01
In the mid-1970s, Donald Hammill and his colleagues authored three scathing critiques of the two most trusted scientific traditions of learning disability treatment--movement education and psycholinguistic training (Hammill, 1972; Hammill & Larsen, 1974; Hammill, Goodman, & Wiederholt, 1974). These critical reviews of research rejected the older…
29 CFR 4010.8 - Plan actuarial information.
2010-07-01
... the extent the qualification(s) are permitted under 26 CFR 301.6059-1(d). (b) Alternative compliance.... Assumptions for decrements other than mortality and retirement (such as turnover or disability) used to... than 25 years of service. Employee A is an active participant who is age 40 and has completed 5...
Actuarial evaluation of the EU proposed farm income stabilisation tool
Pigeon, Mathieu; Frahan, Bruno Henry de; Denuit, Michel
2012-01-01
Recently, the European Commission proposed to introduce several risk management tools in the rural development pillar 2 of the CAP. One of them consists in providing co-financing support to mutual funds compensating farmers who experience a severe drop in their farm income. This paper analyses this new farm income stabilization tool for the Walloon region in Belgium, considering separately three groups of farms (crop, dairy and cattle farms). Relying on FADN data from 1997 to 2007, this analy...
ACTUARIAL ESTIMATION OF TECHNICAL PROVISIONS’ ADEQUACY IN LIFE INSURANCE COMPANIES
Jasmina Selimovic
2010-01-01
When considering company doing business quality it is necessary to evaluate the amount of money that company can operate with. Insurance companies, regarding to all specifics of their business, have to evaluate all technical provisions of the company. Technical provisions, as part of the liabilities in insurers’ balance sheet, are basic measure of business operations quality and safety (i.e. they are the basic guarantee that all obligations to customers will be settled). Technical reserves ar...
Maurin, Krzysztof
1980-01-01
The extraordinarily rapid advances made in mathematics since World War II have resulted in analysis becoming an enormous organism spread ing in all directions. Gone for good surely are the days of the great French "courses of analysis" which embodied the whole of the "ana lytical" knowledge of the times in three volumes-as the classical work of Camille Jordan. Perhaps that is why present-day textbooks of anal ysis are disproportionately modest relative to the present state of the art. More: they have "retreated" to the state before Jordan and Goursat. In recent years the scene has been changing rapidly: Jean Dieudon ne is offering us his monumentel Elements d'Analyse (10 volumes) written in the spirit of the great French Course d'Analyse. To the best of my knowledge, the present book is the only one of its size: starting from scratch-from rational numbers, to be precise-it goes on to the theory of distributions, direct integrals, analysis on com plex manifolds, Kahler manifolds, the theory of sheave...
Multivariate analysis of prognostic factors for differentiated thyroid carcinoma in children
At most centres, the standard treatment for differentiated thyroid cancer (DTC) comprises total thyroidectomy, radioiodine treatment and thyroid-stimulating hormone (TSH) suppressive therapy. There is, however, considerable disagreement over the appropriate treatment for DTC in children. Some dispute the use of total thyroidectomy and/or question the routine application of iodine-131 therapy in children. The aim of this study was to perform a retrospective analysis of treatment results and prognostic factors for DTC in children treated at our centre. The study included 109 children with DTC (aged 6-17 years). The primary treatment comprised total thyroidectomy in 81 cases, radioiodine therapy in 85 cases and TSH suppressive therapy with l-thyroxine in all patients. Uni- and multivariate analysis of prognostic factors for disease-free survival was performed using the Cox regression method. The actuarial survival rate was 100%, and the 5- and 10-year actuarial disease-free survival rates were 80% and 61% respectively. Univariate analysis revealed that older age, total thyroidectomy and radioiodine treatment had a positive impact on disease-free survival whereas there were no statistical differences with regard to the child's sex, histological type of cancer or lymph node status. On multivariate analysis, radical surgery was estimated to be the most significant factor (P=0.007) for disease-free survival, while less than total thyroidectomy increased the relative risk of relapse by a factor of 10. Radioiodine treatment decreased the relative risk of relapse by a factor of 5, but with borderline significance (P=0.07). Permanent postoperative complications were observed in 17% of children: in 11 laryngeal palsy occurred, in six there was hypoparathyroidism, and one suffered from both. It is concluded that total thyroidectomy and radioiodine treatment significantly improve recurrence-free survival in children and should be routinely applied even in young children as the
Purpose: To evaluate the time of onset, method of identification, management, and outcome of pelvic relapse following subtotal lymphoid irradiation (STLI) alone (mantle and paraaortic/spleen or splenic pedicle fields, excluding the pelvis) in supradiaphragmatic Stage I-II Hodgkin's disease. Methods and Materials: A retrospective analysis was performed of the initial, relapse, and regular follow-up evaluations of patients with pelvic relapse following STLI alone from 1968 to the present for supradiaphragmatic Stage I-II Hodgkin's disease after pathologic staging (PS-laparotomy staging) and clinical staging (CS-no laparotomy staging). Results: Following staging, which included bipedal lymphangiography, 482 patients (408 PS and 74 CS), were treated with STLI alone for supradiaphragmatic Stage I-II Hodgkin's disease. The actuarial freedom from relapse at 20 years was 75% in PS patients and 81% in CS patients. The actuarial pelvic failure at 20 years was 7% for PS patients and 3% for CS patients. Of the 29 patients with pelvic relapse, 97% (28 of 29) occurred within 5 years of treatment, including 1 patient who progressed during initial treatment. Pelvic relapse was most commonly initially identified by abnormalities involving patient symptoms (62%), physical examination (55%), erythrocyte sedimentation rate (48%), and bipedal lymphangiogram and/or abdominal radiograph (38%). Relapse was limited to previously unirradiated sites in 17 patients (58%). In addition to pelvic lymph node disease, 3 patients (10%) had involvement of bone, and 4 patients (14%) had bone marrow involvement. Following relapse, all patients were treated with chemotherapy (MOP[P], MOP[P]/ABV[D], ABVD, or PAVe) and 19 of 29 patients received involved field consolidative irradiation. Twenty-one of 29 (72%) remained relapse free at the time of last follow-up evaluation, including 15 of 19 (79%) treated with combined therapy. Eight patients experienced a second relapse despite salvage therapy, and all
Skull base chordomas: analysis of dose-response characteristics
Objective: To extract dose-response characteristics from dose-volume histograms and corresponding actuarial survival statistics for 115 patients with skull base chordomas. Materials and Methods: We analyzed data for 115 patients with skull base chordoma treated with combined photon and proton conformal radiotherapy to doses in the range 66.6Gy - 79.2Gy. Data set for each patient included gender, histology, age, tumor volume, prescribed dose, overall treatment time, time to recurrence or time to last observation, target dose-volume histogram, and several dosimetric parameters (minimum/mean/median/maximum target dose, percent of the target volume receiving the prescribed dose, dose to 90% of the target volume, and the Equivalent Uniform Dose (EUD). Data were analyzed using the Kaplan-Meier survivor function estimate, the proportional hazards (Cox) model, and parametric modeling of the actuarial probability of recurrence. Parameters of dose-response characteristics were obtained using the maximum likelihood method. Results: Local failure developed in 42 (36%) of patients, with actuarial local control rates at 5 years of 59.2%. The proportional hazards model revealed significant dependence of gender on the probability of recurrence, with female patients having significantly poorer prognosis (hazard ratio of 2.3 with the p value of 0.008). The Wilcoxon and the log-rank tests of the corresponding Kaplan-Meier recurrence-free survival curves confirmed statistical significance of this effect. The Cox model with stratification by gender showed significance of tumor volume (p=0.01), the minimum target dose (p=0.02), and the EUD (p=0.02). Other parameters were not significant at the α level of significance of 0.05, including the prescribed dose (p=0.21). Parametric analysis using a combined model of tumor control probability (to account for non-uniformity of target dose distribution) and the Weibull failure time model (to account for censoring) allowed us to estimate
Hazard function analysis for flood planning under nonstationarity
Read, Laura K.; Vogel, Richard M.
2016-05-01
The field of hazard function analysis (HFA) involves a probabilistic assessment of the "time to failure" or "return period," T, of an event of interest. HFA is used in epidemiology, manufacturing, medicine, actuarial statistics, reliability engineering, economics, and elsewhere. For a stationary process, the probability distribution function (pdf) of the return period always follows an exponential distribution, the same is not true for nonstationary processes. When the process of interest, X, exhibits nonstationary behavior, HFA can provide a complementary approach to risk analysis with analytical tools particularly useful for hydrological applications. After a general introduction to HFA, we describe a new mathematical linkage between the magnitude of the flood event, X, and its return period, T, for nonstationary processes. We derive the probabilistic properties of T for a nonstationary one-parameter exponential model of X, and then use both Monte-Carlo simulation and HFA to generalize the behavior of T when X arises from a nonstationary two-parameter lognormal distribution. For this case, our findings suggest that a two-parameter Weibull distribution provides a reasonable approximation for the pdf of T. We document how HFA can provide an alternative approach to characterize the probabilistic properties of both nonstationary flood series and the resulting pdf of T.
In a previous analysis (Int J Radiat Oncol Biol Phys 70:828-835,2010), we assessed whether an adjuvant supplementation with selenium (Se) improves Se status and reduces the radiation-induced side-effects of patients treated by adjuvant radiotherapy (RT) for cervical and uterine cancer. Now, a potential relation between the planning target volume (PTV) of the RT and the Se effect concerning radiation induced diarrhoea was evaluated in detail. Whole blood Se concentrations had been measured in patients with cervical (n=11) and uterine cancer (n=70) after surgical treatment, during, and at the end of RT. Patients with initial Se concentrations of less than 84 μg/l were categorized as Se-deficient and randomized before RT to receive Se (as sodium selenite) per os on the days of RT, or to receive no supplement during RT. Diarrhoea was graded according to the Common Toxicity Criteria system (CTC, Version 2a). The evaluation of the PTV of the RT was ascertained with the help of a specialised computer-assisted treatment planning software used for radiation planning procedure. A total of 81 patients had been randomized for the initial supplementation study, 39 of which received Se [selenium group, SeG] and 42 serving as controls [control group, CG]. Mean Se levels did not differ between SeG and CG upon study initiation, but were significantly higher in the SeG compared to the CG at the end of RT. The actuarial incidence of at least CTC 2 radiation induced diarrhoea in the SeG was 20.5% compared to 44.5% in the CG (p=0.04). The median PTV in both groups was 1302 ml (916–4608). With a PTV of <= 1302 ml (n=41) the actuarial incidence of at least CTC 2 diarrhoea in the SeG was 22.3% (4 of 18 patients) compared to 34.8% (8 of 23 patients) in the CG (p=0.50). In patients with a PTV of > 1302 ml (n=40) the actuarial incidence of at least CTC 2 diarrhoea in the SeG was 19.1% (4 of 21 patients) versus 52.6% (10 of 19 patients) in the CG (p=0.046). Se supplementation during RT was
JeongYeon Kim
2014-01-01
This study reviews new pension accounting with K-IFRS and provides empirical changes in liability for retirement allowances with adoption of K-IFRS. It will help to understand the effect of pension accounting on individual firm’s financial report and the importance of public announcement of actuarial assumptions. Firms that adopted K-IFRS had various changes in retirement liability compared to the previous financial report not based on K-IFRS. Their actuarial assumptions for pension accountin...
Risk analysis of linear accelerator radiosurgery
Purpose: To evaluate the toxicity of stereotactic single-dose irradiation and to compare the own results with already existing risk prediction models. Methods and Materials: Computed tomography (CT) or magnetic-resonance (MR) images, and clinical data of 133 consecutive patients treated with linear accelerator radiosurgery were analyzed retrospectively. Using the Cox proportional hazards model the relevance of treatment parameters and dose-volume relationships on the occurrence of radiation-induced tissue changes (edema, localized blood-brain barrier breakdown) were assessed. Results: Sixty-two intraparenchymal lesions (arteriovenous malformation (AVM): 56 patients, meningioma: 6 patients) and 73 skull base tumors were selected for analysis. The median follow-up was 28.1 months (range: 9.0-58.9 months). Radiation-induced tissue changes (32 out of 135, 23.7%) were documented on CT or MR images 3.6-58.7 months after radiosurgery (median time: 17.8 months). The actuarial risk at 2 years for the development of neuroradiological changes was 25.8% for all evaluated patients, 38.4% for intraparenchymal lesions, and 14.6% for skull base tumors. The coefficient: total volume receiving a minimum dose of 10 Gy (VTREAT10) reached statistical significance in a Cox proportional hazards model calculated for all patients, intraparenchymal lesions, and AVMs. In skull base tumors, the volume of normal brain tissue covered by the 10 Gy isodose line (VBRAIN10) was the only significant variable. Conclusions: These results demonstrate the particular vulnerability of normal brain tissue to single dose irradiation. Optimal conformation of the therapeutic isodose line to the 3D configuration of the target volume may help to reduce side effects
Luis Ceferino Franco Arbeláez
2008-07-01
Full Text Available Este artículo es resultado de un proyecto de investigación sobre la gestión integral del riesgo operacional promovido por la Vicerrectoria de Investigaciones de la Universidad de Medellín, y cofinanciado por una firma comisionista. Se presenta una aplicación del modelo LDA, el cual se basa en la recopilación de los datos de pérdidas históricas (frecuencia y severidad, que se registran internamente en las organizaciones. Dichos datos pueden ser complementados con datos externos. Estas pérdidas son clasificadas en una matriz que relaciona las líneas de negocio de la organización y los eventos operacionales de pérdida, a partir de la cual se calcula la carga de capital. La aplicación se desarrolló para una entidad financiera. El artículo está organizado de la siguiente forma: la primera sección es introductoria al tema. En la segunda parte se presenta formalmente el modelo LDA; luego se realiza una aplicación, y en la cuarta sección se presentan algunas conclusiones.This paper is the result of a research project on integrated management of operational risk, promoted by Universidad de Medellin Research Vice-Principal's Office and co-financed by a financial company. It presents an application of the LDA model, which is based on data collection of historical losses (frequency and severity, which are recorded internally in organizations. Such data can be supplemented with external data. These losses are classified in a matrix that relates business lines of the organization and operational loss events, from which capital charge is estimated. The application was developed for a financial institution. The paper is organized as follows: The first section is introductory to the subject. The second part formally presents a LDA model; then an application is made, and in the fourth part some conclusions are presented.
Purpose: To present 5-year data on treatment efficacy, cosmetic results, and toxicities for patients enrolled on the American Society of Breast Surgeons MammoSite breast brachytherapy registry trial. Methods and Materials: A total of 1440 patients (1449 cases) with early-stage breast cancer receiving breast-conserving therapy were treated with the MammoSite device to deliver accelerated partial-breast irradiation (APBI) (34 Gy in 3.4-Gy fractions). Of 1449 cases, 1255 (87%) had invasive breast cancer (IBC) (median size, 10 mm) and 194 (13%) had ductal carcinoma in situ (DCIS) (median size, 8 mm). Median follow-up was 54 months. Results: Thirty-seven cases (2.6%) developed an ipsilateral breast tumor recurrence (IBTR), for a 5-year actuarial rate of 3.80% (3.86% for IBC and 3.39% for DCIS). Negative estrogen receptor status (p = 0.0011) was the only clinical, pathologic, or treatment-related variable associated with IBTR for patients with IBC and young age (<50 years; p = 0.0096) and positive margin status (p = 0.0126) in those with DCIS. The percentage of breasts with good/excellent cosmetic results at 60 months (n = 371) was 90.6%. Symptomatic breast seromas were reported in 13.0% of cases, and 2.3% developed fat necrosis. A subset analysis of the first 400 consecutive cases enrolled was performed (352 with IBC, 48 DCIS). With a median follow-up of 60.5 months, the 5-year actuarial rate of IBTR was 3.04%. Conclusion: Treatment efficacy, cosmesis, and toxicity 5 years after treatment with APBI using the MammoSite device are good and similar to those reported with other forms of APBI with similar follow-up.
Background and purpose: There is still a concern that the use of HDR brachytherapy might result in an increase of late tissue damage. This retrospective study evaluates the incidence and severity of late complications in patients with carcinoma of the cervix who underwent combined external beam radiation (EBR) and Ir-192 HDR brachytherapy and attempts to identify pretreatment and treatment parameters correlating with late complications. Material and methods: Between 1985 and 1992, 161 patients with carcinoma of the cervix (FIGO stages IB-IVB) received EBR to the pelvis (ave. max. dose 48.8 Gy) followed by 1-6 Ir-192 HDR placements (median 2). Doses to point A ranged from 8.5 to 38.7 Gy (median 17 Gy). Parameters examined included age, diabetes, obesity, history of inflammatory bowel disease or diverticulitis, prior surgery, hemoglobin level, FIGO stage, EBR dose, technique and daily dose fraction, number of HDR treatments and total dose to point A, maximum doses to bladder and rectum delivered by brachytherapy and cumulative dose to point A. Median follow-up for all patients was 37 months. Complications were rated using an in-house scoring system and according to the French-Italian Glossary (FIG). Results: Actuarial 5-year survival was 93%, 57%, 46%, and 0% for stages IB, II, IIIB, and IV, respectively. Of 161 patients, 11% developed moderate and 3.7% severe sequelae (FIG: 2.5%, 3.7%). Since some patients experienced more than one complication, the overall incidence was 13.6% and 4.9% (FIG: 3.1%, 4.9%) with respective 5-year actuarial rates of 14% and 5% for moderate, and 2% and 8% for severe bowel and genitourinary tract complications (FIG: 3.5%, 0, and 2%, 8%). All severe bowel complications occurred within 1.5 years whereas urinary tract sequelae continued to develop throughout the follow-up period. FIGO stage was associated with a significant increase in late sequelae (P=0.015). Analysis of the remaining pretreatment and treatment parameters failed to reveal
成本建模与原价分析%Cost Modeling and Original Price Analysis
王涛; 袁建新
2015-01-01
根据汽车钣金件加工特点，在建立同质作业成本库的基础上，对钣金件产品原价进行数学模型构建，通过模型的运用，实现钣金件产品原价的分析与精算工作，从而发现成本控制点，最终达到节约采购成本、降低采购价格的目的。%In the light of the processing characteristics of automotive sheet metal parts, and based on the establishment of the homogeneous cost pool, we construct the mathematical model of sheet metal products’ original price.By using the models, we make the original price analysis and carry out the sheet metal products’ actuarial work, so the cost control point is found, and ultimately it is realized to save procurement costs and reduce the purchase price.
Gamma knife radiosurgery for acoustic neurinomas. Pt. 2. The analysis of functional outcome
Forty-three patients with the unilateral type of acoustic neurinoma treated by gamma knife radiosurgery were evaluated from the viewpoint of functional preservation of cranial nerves and complications. The follow-up period ranged from 22 to 55 months (mean 36 months). The tumors, which ranged in volume from 0.1 to 18.7 ml (mean 4.0 ml), were treated with marginal radiation doses of 9-15 Gy (mean 13.4 Gy) with multiple isocenters (mean 8.7). Functional hearing was preserved in 80% of patients, and actuarial hearing preservation rates were 83% at 1 year, 77% at 2 years, and 77% at 3 years after gamma knife radiosurgery. No factor was found to correlate with hearing deterioration using Cox's proportional hazards regression model. Transient facial and trigeminal neuropathies occurred in 2.3% and 4.7% of patients, respectively. Ten patients (23%) experienced transient dizziness 3 to 6 months after radiosurgery, but only preradiosurgery canal palsy was found to correlate with this using multiple regression analysis (p=0.02). Three patients developed communicating hydrocephalus, which may have been due to the high cerebrospinal fluid protein concentration (mean 149 mg/dl). Our results show that gamma knife radiosurgery should be considered as alternative therapy for patients with small-to medium-sized acoustic neurinomas, especially in those with functional hearing, due to the high cranial nerve function preservation rates achieved with this procedure. (author)
Brown, Sarah; Harkins, Leigh; Beech, Anthony R
2012-10-01
An empathy-related component has been included in most sex offender treatment programs since the 1980s; however, research linking empathy to sexual offending and/or to treatment outcome has produced mixed findings. This study examined the relationship between victim specific empathy, general empathy, and overall treatment change (determined by responses on a battery of psychometric tests) with static risk (Risk Matrix 2000 [RM 2000]) and sexual offense reconviction data in a sample of 105 offenders who completed treatment while in prison or in the community in England and Wales and followed up for an average period of more than 10 years. Victim-specific empathy improved from pretreatment to posttreatment and related to overall treatment change. A small group of offenders, whose victim empathy scores deteriorated from pretreatment to posttreatment, had higher rates of sexual recidivism compared with the rest of the sample. In contrast, neither were any reliable pretreatment to posttreatment changes noted on general empathy scores, except for an indication on the Interpersonal Reactivity Index Personal Distress Scale, nor was any relationship found to sexual recidivism. The implications of these findings are discussed in relation to treatment goals and sexual recidivism. PMID:22179773
Composite Weibull-Inverse Transformed Gamma distribution and its actuarial application
Maghsoudi, Mastoureh; Bakar, Shaiful Anuar Abu; Hamzah, Nor Aishah
2014-07-01
This paper introduces a new composite model, namely, composite Weibull-Inverse Transformed Gamma distribution which assumes Weibull distribution for the head up to a specified threshold and inverse transformed gamma distribution beyond it. The closed form of probability density function (pdf) as well as the estimation of parameters by maximum likelihood method is presented. The model is compared with several benchmark distributions and their performances are measured. A well-known data set, Danish fire loss data, is used for this purpose and it's Value at Risk (VaR) using the new model is computed. In comparison to several standard models, the composite Weibull- Inverse Transformed Gamma model proved to be a competitor candidate.
Lindsay, William R.; Beail, Nigel
2004-01-01
Background: Research on prediction of violent and sexual offending behaviour has developed considerably in the mainstream criminological literature. Apart from one publication [Quinsey (2004) "Offenders with Developmental Disabilities," pp. 131-142] this has not been extended to the field of intellectual disabilities. Methods: Work on actuarial…
Why not private health insurance? 2. Actuarial principles meet provider dreams.
Deber, R; Gildiner, A; Baranek, P
1999-09-01
What do insurers and employers feel about proposals to expand Canadian health care financing through private insurance, in either a parallel stream or a supplementary tier? The authors conducted 10 semistructured, open-ended interviews in the autumn and early winter of 1996 with representatives of the insurance industry and benefits managers working with large employers; respondents were identified using a snowball sampling technique. The respondents felt that proposals for parallel private plans within a competitive market are incompatible with insurance principles, as long as a well-functioning and relatively comprehensive public system continues to exist; the maintenance of a strong public system was both socially and economically desirable. With the exception of serving the niche market for the private management of return-to-work strategies, respondents showed little interest in providing parallel coverage. They were receptive to a larger role for supplementary insurance but cautioned that they are not willing to cover all delisted services. As business executives they stated that they are willing to insure only services and clients that will be profitable. PMID:10497614
McMillan, Dean; Hastings, Richard P.; Coldwell, Jon
2004-01-01
Background: There is a high rate of physical violence in populations with intellectual disabilities, and this has been linked to problems for the victim, the assailant, members of staff and services. Despite the clinical significance of this behaviour, few studies have assessed methods of predicting its occurrence. The present study examined…
Pallone, Nathaniel J.; Hennessy, James J.; Voelbel, Gerald T.
1998-01-01
A scientifically sound methodology for identifying offenders about whose presence the community should be notified is demonstrated. A stepwise multiple regression was calculated among incarcerated pedophiles (N=52) including both psychological and legal data; a precision-weighted equation produced 90.4% "true positives." This methodology can be…
THE EVOLUTION AND FUTURE OF SOCIAL SECURITY IN AFRICA: AN ACTUARIAL PERSPECTIVE
Fatima Badat; Kudzai Chigiji; Johann Söhnge; Krishen Sukdev; Natalie Van Zyl
2015-01-01
Social Security in most African countries has evolved significantly in terms of perspectives, motives, governance as well as innovation of benefits and administration. African countries are slowly, one by one, beginning to reassess the role of social security in correcting several social ills. Empowerment programs and grants are increasingly being provided via social security to women and the youth. From the roots of social security, even very low income countries, some of which have recently...
Actuarial assessment of future loss scenarios in the German insurance sector
Kubik, A.; Boehm, U.; Born, K.; Broecker, U.; Buechner, M.; Burghoff, O.; Donat, M.; Gerstengarbe, F. W.; Hattermann, F. F.; Held, H.; Kuecken, M.; Leckebusch, G. C.; Ludwig, P.; Nocke, T.; Oesterle, H.; Pardowitz, T.; Pinto, J. G.; Prahl, B. F.; Ulbrich, U.; Werner, P. C.
2012-04-01
The German Insurance Association (GDV) analyzed the impacts of climate change for the German insurance market. The work was conducted in cooperation with Potsdam Institute for Climate Impact Research, Freie Universität Berlin and University of Cologne. Different approaches and data sets were used to analyze the impacts of winter storm, hail and floods. High-resolution loss records to residential buildings in Germany were provided. These daily records are available on a fine spatial level of administrative districts from 1997-2007. For the period of 1984-2008 daily losses to residential buildings were derived from motor vehicle own damage insurance, which shows a surprisingly high correlation between building losses and motor vehicle losses caused by natural hazards. Loss functions from GDVs own flood risk model were made available to estimate flood losses. As climate change will progress the mean annual losses in the private residential building insurance might increase. Until 2100 losses due to winter storm could rise by more than 50%. The increase is mainly attributable to the intensification of individual exceptionally severe storms. Climate change will also result in an increase of flood losses. By the end of the century mean losses are expected to be twice as high - depending on the given scenario they could remain constant or triple. Conversely extreme events with high cumulative losses are expected to become significantly more frequent. Storms with a today's return period of 50 years might occur every 10 years at the end of the century. Floods, now returning every 50 years, could arise every 25 years. For the first time hailstorms have been analyzed. It was noticed, that in particular East Germany might be hit more frequently. Despite these findings, i.e. the cost of insurance against natural hazards might increase, the extent of such an increase in Germany should still remain within limits that can be mastered by the insurance companies. But we have to adapt to climate change. For this purpose stakeholder usually need ascertained numbers. Because our results were achieved using ensemble techniques they display per se a considerable spread. Despite this fact our results are robust over all approaches and climate models. Therefore they can be used for strategic decisions, less for daily routine business. Higher and more frequent losses will require higher venture capital and must be taken into account when implementing the EU directive Solvency II. If we assess our results carefully and act farseeing, we will be able to draw from manifold activities to deal with climate change impacts. Smart portfolio policy can help to reduce risks. Working with limits and franchises can help to insure highly exposed risks. Therefore GDV offers to his member companies wide accepted tools and risk models such as ZÜRS Geo, HQ Kumul and detailed risk statistics. After all, well-directed information policy, increased risk awareness and preventive action can reduce climate change impacts significantly.
Reproductive effort accelerates actuarial senescence in wild birds : An experimental study
Boonekamp, Jelle J.; Salomons, Martijn; Bouwhuis, Sandra; Dijkstra, Cornelis; Verhulst, Simon
2014-01-01
Optimality theories of ageing predict that the balance between reproductive effort and somatic maintenance determines the rate of ageing. Laboratory studies find that increased reproductive effort shortens lifespan, but through increased short-term mortality rather than ageing. In contrast, high fec
Actuarial Risk Assessment and Recidivism in a Sample of UK Intellectually Disabled Sexual Offenders
Wilcox, Dan; Beech, Anthony; Markall, Helena F.; Blacker, Janine
2009-01-01
This study examines the effectiveness of three risk assessment instruments: Static-99, Risk Matrix 2000 (RM2000) and the Rapid Risk of Sex Offender Recidivism (RRASOR), in predicting sexual recidivism among 27 intellectually disabled sex offenders. The overall sexual offence reconviction rate was 30%, while non-recidivists remained offence-free…
Provision of financial security for nuclear facilities taking into account actuarial preconditions
The Atomic Energy Act clearly differentiates between financial security to be provided by the owner of the nuclear facility on the basis of his costs, and an indemnification by the Bund based thereon in cases of emergency. Questions relevant to the nuclear insurance carriers resulting from the Third Act amending the Atomic Energy Act and from the amendment and supplement to the ordinance concerning the provision of financial security are discussed in detail and model solutions are proposed. (HP/LN)
Records of 154 patients with Ewing's sarcoma treated at the National Cancer Institute were reviewed to assess the incidence and risk of developing isolated central nervous system (CNS) Ewing's sarcoma. Sixty-two of the 154 patients had received CNS irradiation and intrathecal (i.t.) methotrexate as part of their initial therapy to prevent the occurrence of isolated CNS Ewing's sarcoma. The risk of developing isolate CNS Ewing's sarcoma was greatest within the first two years after diagnosis and was approximately 10%. The overall risk of CNS recurrence in the group of patients receiving DNS treatment was similar to the group receiving no therapy directed to the CNS. The occurrence of isolated CNS involvement was not prevented by the use of CNS irradiation and i.t. methotrexate. Because of a lack of efficacy to the CNS irradiation regimen, current treatment regimens do not include therapy directed to CNS
2013-01-04
.../ Information Delivery Services (IDS)/Corporate & Financial Reporting Group, Hartford, CT; Notice of Affirmative... (IDS)/Corporate & Financial Reporting group, Hartford, Connecticut (The Hartford-IDS Group). The... basis for the negative determination. The Hartford-IDS Group is engaged in activities related to...
2011-11-01
... cost of incurred- but-not-reported benefits together with variations between actual and estimated cost... of December 2012 under the assumptions used in preparing this report. This amounts to 28.4 percent of... not included in the definition of a small entity. This notice will not have a significant impact on...
Ghia, Amol J; Chang, Eric L; Bishop, Andrew J; Pan, Hubert Y; Boehling, Nicholas S; Amini, Behrang; Allen, Pamela K; Li, Jing; Rhines, Laurence D; Tannir, Nizar M; Tatsui, Claudio E; Brown, Paul D; Yang, James N
2016-05-01
OBJECTIVE The objective of this study was to compare fractionation schemes and outcomes of patients with renal cell carcinoma (RCC) treated in institutional prospective spinal stereotactic radiosurgery (SSRS) trials who did not previously undergo radiation treatment at the site of the SSRS. METHODS Patients enrolled in 2 separate institutional prospective protocols and treated with SSRS between 2002 and 2011 were included. A secondary analysis was performed on patients with previously nonirradiated RCC spinal metastases treated with either single-fraction (SF) or multifraction (MF) SSRS. RESULTS SSRS was performed in 47 spinal sites on 43 patients. The median age of the patients was 62 years (range 38-75 years). The most common histological subtype was clear cell (n = 30). Fifteen sites underwent surgery prior to the SSRS, with laminectomy the most common procedure performed (n = 10). All SF SSRS was delivered to a dose of 24 Gy (n = 21) while MF regiments were either 27 Gy in 3 fractions (n = 20) or 30 Gy in 5 fractions (n = 6). The median overall survival duration for the entire cohort was 22.8 months. The median local control (LC) for the entire cohort was 80.6 months with 1-year and 2-year actuarial LC rates of 82% and 68%, respectively. Single-fraction SSRS correlated with improved 1- and 2-year actuarial LC relative to MF SSRS (95% vs 71% and 86% vs 55%, respectively; p = 0.009). On competing risk analysis, SF SSRS showed superior LC to MF SSRS (subhazard ratio [SHR] 6.57, p = 0.014). On multivariate analysis for LC with tumor volume (p = 0.272), number of treated levels (p = 0.819), gross tumor volume (GTV) coverage (p = 0.225), and GTV minimum point dose (p = 0.97) as covariates, MF SSRS remained inferior to SF SSRS (SHR 5.26, p = 0.033) CONCLUSIONS SSRS offers durable LC for spinal metastases from RCC. Single-fraction SSRS is associated with improved LC over MF SSRS for previously nonirradiated RCC spinal metastases. PMID:26799117
Purpose: To evaluate the long-term outcome of surgery and postoperative radiotherapy (RT) in retroperitoneal and deep-trunk soft-tissue sarcoma, and to identify the prognostic factors for local control, disease-free survival, and overall survival. Methods and Materials: Between January 1980 and December 1998, 60 patients with nonmetastatic retroperitoneal and deep-trunk soft-tissue sarcoma were treated at Wayne State University using combined surgery and RT. The location was retroperitoneal in 38 patients (63%) and deep trunk in 22 (27%). Forty-six patients (76%) were treated for primary disease and 14 (24%) for recurrent disease. The resection margins were negative in 24 patients (40%), close in 3 (5%), and positive in 33 (55%; 18 microscopic and 15 macroscopic). The median tumor size was 8.6 cm (range 2-55). External beam RT (EBRT; median dose 5220 cGy) was given to 44 patients (73%) and combined EBRT (median dose 4200 cGy) and brachytherapy (median dose 1600 cGy) to 16 patients (27%). Univariate and multivariate Cox regression analyses were conducted to identify the possible associations between patient age, race, gender, tumor site, histologic features, grade, size, stage, surgical margin, RT dose, modality (EBRT vs. EBRT plus brachytherapy), and presentation (primary vs. recurrent) and disease control. Results: The actuarial 5- and 10-year disease-free survival rate was 53% and 44%, respectively. Disease-free survival was significantly associated with female gender on univariate analysis (67% for female patients and 37% for male patients at 5 years, p=0.05). On multivariate analysis, both gender and surgical margin had borderline significance (p=0.06). The actuarial local control rate was 71% and 54% at 5 and 10 years, respectively. The median time to local relapse was 10.2 months, with 75% of all failures occurring within 29 months. The surgical margin status was significantly associated with local control (78% for patients with negative or close margins vs
CLUSTER ANALYSIS OF NATURAL DISASTER LOSSES IN POLISH AGRICULTURE
Grzegorz STRUPCZEWSKI
2015-04-01
Full Text Available Agricultural production risk is of special nature due to a great number of hazards, relative weakness of production entities on the market and high ambiguity which is greater than in industrial production. Natural disasters occurring very frequently, at simultaneous low percentage of insured farmers, cause damage of such sizes that force the state to organise current financial aid (for instance in the form of preferential natural disaster loans. This aid is usually not sufficient. On the other hand, regional diversity of the risk level does not positively affect the development of insurance. From the perspective of insurance companies and policymakers it becomes highly important to investigate the spatial structure of losses in agriculture caused by natural disasters. The purpose of the research is to classify the 16 Polish voivodeships into clusters in order to show differences between them according to the criterion of level of damage in agricultural farms caused by natural disasters. On the basis of the cluster analysis it was demonstrated that 11 voivodeships form quite a homogeneous group in terms of size of damage in agriculture (the value of damage in cultivations and the acreage of destroyed cultivations are two most important factors determining affiliation to the cluster, however, the profile of loss occurring in other five voivodeships has a very individual course and requires separate handling in the actuarial sense. It was also proved that high value of losses in agriculture in the absolute sense in given voivodeships do not have to mean high vulnerability of agricultural farms from these voivodeships to natural risks.
Purpose: The purpose of this paper is to use the outcome of a dose escalation protocol for three-dimensional conformal radiation therapy (3D-CRT) of prostate cancer to study the dose-response for late rectal toxicity and to identify anatomic, dosimetric, and clinical factors that correlate with late rectal bleeding in multivariate analysis. Methods and Materials: Seven hundred forty-three patients with T1c-T3 prostate cancer were treated with 3D-CRT with prescribed doses of 64.8 to 81.0 Gy. The 5-year actuarial rate of late rectal toxicity was assessed using Kaplan-Meier statistics. A retrospective dosimetric analysis was performed for patients treated to 70.2 Gy (52 patients) or 75.6 Gy (119 patients) who either exhibited late rectal bleeding (RTOG Grade 2/3) within 30 months after treatment (i.e., 70.2 Gy--13 patients, 75.6 Gy--36 patients) or were nonbleeding for at least 30 months (i.e., 70.2 Gy--39 patients, 75.6 Gy--83 patients). Univariate and multivariate logistic regression was performed to correlate late rectal bleeding with several anatomic, dosimetric, and clinical variables. Results: A dose response for ≥ Grade 2 late rectal toxicity was observed. By multivariate analysis, the following factors were significantly correlated with ≥ Grade 2 late rectal bleeding for patients prescribed 70.2 Gy: 1) enclosure of the outer rectal contour by the 50% isodose on the isocenter slice (i.e., Iso50) (p max (p max
Purpose: A literature review and analysis was performed to determine whether or not efficacious high dose rate (HDR) brachytherapy fractionation schedules exist for the treatment of cervical cancer. Methods and Materials: English language publications from peer reviewed journals were assessed to calculate the total contribution of dose to Point A from both the external and intracavitary portions of radiation for each stage of cervical cancer. Using the linear quadratic formula, the biologically effective dose to the tumor, using an α/β = 10, was calculated to Point A (Gy10) in order to determine a dose response relationship for local control and survival. Significant complications were assessed by calculating the dose to the late-responding tissues at Point A using an α/β = 3 (Gy3) as a surrogate for normal tissue tolerance, since few publications list the actual bladder and rectal doses. Results: For all stages combined, the median external beam fractionation schedule to Point A was 40 Gy in 20 fractions, while the median HDR fractionation schedule was 28 Gy in 4 fractions. For stages IB, IIB, and IIIB the median biologically effective dose to Point A (Gy10) was 96, 96 and 100 Gy10s, respectively. No correlation was identified between Point A BED (Gy10s) to either survival or pelvic control. A dose response relationship could also not be identified when correlating Point A Gy3s to complications. Conclusion: A dose response relationship could not be identified for either tumor control nor late tissue complications. These findings do not necessarily question the validity of the linear quadratic model, as much as they question the quality of the current HDR brachytherapy literature as it is currently presented and reported. Most of the HDR publications report inadequate details of the dose fractionation schedules. Only a minority of publications report significant complications using the actuarial method. In the future, all HDR publications for the treatment of
G K Rath
2015-01-01
Full Text Available CONTEXT AND AIM: The prognosis of primary gliosarcoma (PGS remains dismal with current treatment modalities. We analyzed the outcome of PGS patients treated with concurrent and adjuvant temozolomide (TMZ. SETTINGS AND DESIGN: Retrospective single institutional analysis. MATERIALS AND METHODS: We retrospectively evaluated 27 patients of PGS treated with radiotherapy (RT and TMZ during 2007-2012. STATISTICAL ANALYSIS USED: Overall survival (OS was estimated by the use of Kaplan Meier method and toxicities were evaluate using common terminology criteria for adverse events version 2.0 (National Cancer Institute, USA. RESULTS: Median age at presentation and Karnofsky performance status was 45 years and 90 respectively and male: female ratio was 20:7. Patients received adjuvant RT to a total dose of 60 Gy at 2 Gy/fraction. All patients except 5 received adjuvant TMZ to a median number of 6 cycles. Grade 2 and 3 hematological toxicity was seen in 8% and 4% of patients respectively during concurrent RT. During adjuvant chemotherapy, 13.6% had Grade 3 thrombocytopenia and 9.5% had Grade 3 neutropenia. Median OS was 16.7 months (1 year and 2 year actuarial OS was 70.8% and 32.6% respectively. Adjuvant TMZ was associated with a better survival (median survival 21.21 vs. 11.93 months; P = 0.0046 on univariate analysis and also on multivariate analysis (hazard ratio 1.82, 95% confidence interval: 1.503-25.58; P = 0.012. CONCLUSIONS: The results of our study, largest series of patients with PGS treated with concurrent and adjuvant TMZ shows an impressive survival with acceptable toxicity. We suggest TMZ be included in the “standard of care” for this tumor.
Purpose: In order to obtain the standard treatment results of medically inoperable non-small cell lung cancer (NSCLC) in Stage I in the post-CT scan era, a retrospective analysis of patients who were treated by radical radiotherapy was performed. Methods and materials: 149 cases treated between 1980 and 1989 were accumulated from ten large hospitals in Japan. All patients received a total dose of 55-75 Gy (mean 64.7 Gy) with conventional fractionation. For evaluation of treatment results, complete response (CR) rate, median survival period and long-termed survival rates were used. Results: The median survival of the all cases was 27.2 months and the actuarial 3- and 5-year survival rates were 34.2% and 22.2%, respectively. CR was obtained in 57 cases (38%). The CR rate was strongly correlated with the long-term survival (5-year survival rate in CR group: 35.1% compared with PR + NC group: 14.1% (P<0.0001)). The size of tumor was also of prognostic importance. In 116 patients who died within 5 years after treatment, 66 patients (57%) died of local tumor regrowth. Conclusion: Although the medically inoperable NSCLC patients in Stage I should be offered curative radiation therapy, development of some new steps to increase the CR rate and local control rate is urgently needed
Time complexity analysis of genetic- fuzzy system for disease diagnosis
Ephzibah.E.P
2011-01-01
A new generation of tools and techniques are needed for finding interesting patterns in the data and discovering useful knowledge. Especially, Medical knowledge consists of a combination of structural information about known biological facts and probabilistic or actuarial information about exposures tohazards and recovery rates. Probabilistic information is especially difficult to use, as it requires constant maintenance and it usually comes in the form of study results which are not ideally ...
The biochemical relapse-free survival (bRFS) rate after treatment with permanent iodine-125 seed implantation (PSI) or combined seeds and external beam radiotherapy (COMB) for clinical stage T1-T2 localized prostate cancer is a clinically relevant endpoint. The goal of this work was to evaluate the influence of relevant patient- and treatment-related factors. The study population comprised 312 consecutive patients treated with permanent seed implantation. All patients were evaluable for analysis of overall survival (OS) and disease-specific survival (DSS), 230 for bRFS, of which 192 were in the PSI group and 38 in the COMB group. The prescribed minimum peripheral dose was 145 Gy for PSI, for COMB 110 Gy implant and external beam radiotherapy of 45 Gy. The median follow-up time was 33 months (range 8-66 months). bRFS was defined as a serum prostate-specific antigen (PSA) level ≤ 0.2 ng/ml at last follow-up. Overall, the actuarial bRFS at 50 months was 88.4 %. The 50-month bRFS rate for PSI and COMB was 90.9 %, and 77.2 %, respectively. In the univariate analysis, age in the categories ≤ 63 and > 63 years (p < 0.00), PSA nadir (≤ 0.5 ng/ml and > 0.5 ng/ml) and PSA bounce (yes/no) were the significant predicting factors for bRFS. None of the other patient and treatment variables (treatment modality, stage, PSA, Gleason score, risk group, number of risk factors, D90 and various other dose parameters) were found to be a statistically significant predictor of 50-month bRFS. The biochemical failure rates were low in this study. As a proof of principle, our large monocenteric analysis shows that low-dose-rate brachytherapy is an effective and safe procedure for patients with early stage prostate cancer. (orig.)
Purpose. To estimate retrospectively the rate of isolated nodal failures (INF) in NSCLC patients treated with the elective nodal irradiation (ENI) using 3D-conformal radiotherapy (3D-CRT). Materials/methods. One hundred and eighty-five patients with I-IIIB stage treated with 3D-CRT in consecutive clinical trials differing in an extent of the ENI were analyzed. According to the extent of the ENI, two groups were distinguished: extended (n=124) and limited (n=61) ENI. INF was defined as regional nodal failure occurring without local progression. Cumulative Incidence of INF (CIINF) was evaluated by univariate and multivariate analysis with regard to prognostic factors. Results. With a median follow up of 30 months, the two-year actuarial overall survival was 35%. The two-year CIINF rate was 12%. There were 16 (9%) INF, eight (6%) for extended and eight (13%) for limited ENI. In the univariate analysis bulky mediastinal disease (BMD), left side, higher N stage, and partial response to RT had a significant negative impact on the CIINF. BMD was the only independent predictor of the risk of incidence of the INF (p=0.001). Conclusions. INF is more likely to occur in case of more advanced nodal status
Kepka, Lucyna; Bujko, Krzysztof; Zolciak-Siwinska, Agnieszka (Dept. of Radiation Oncology, M. Sklodowska-Curie Memorial Cancer Center and Inst. of Oncology, Warsaw (Poland))
2008-01-15
Purpose. To estimate retrospectively the rate of isolated nodal failures (INF) in NSCLC patients treated with the elective nodal irradiation (ENI) using 3D-conformal radiotherapy (3D-CRT). Materials/methods. One hundred and eighty-five patients with I-IIIB stage treated with 3D-CRT in consecutive clinical trials differing in an extent of the ENI were analyzed. According to the extent of the ENI, two groups were distinguished: extended (n=124) and limited (n=61) ENI. INF was defined as regional nodal failure occurring without local progression. Cumulative Incidence of INF (CIINF) was evaluated by univariate and multivariate analysis with regard to prognostic factors. Results. With a median follow up of 30 months, the two-year actuarial overall survival was 35%. The two-year CIINF rate was 12%. There were 16 (9%) INF, eight (6%) for extended and eight (13%) for limited ENI. In the univariate analysis bulky mediastinal disease (BMD), left side, higher N stage, and partial response to RT had a significant negative impact on the CIINF. BMD was the only independent predictor of the risk of incidence of the INF (p=0.001). Conclusions. INF is more likely to occur in case of more advanced nodal status
Purpose: To evaluate the results of salvage radiotherapy (RT) after inadequate surgery in patients with invasive carcinoma of the cervix. Methods and Materials: Between 1996 and 2001, 105 invasive cervical carcinoma patients were treated at our center with external beam RT with or without intracavitary RT after having undergone total/subtotal hysterectomy at outside institutions. Results: The median follow-up was 34 months. The gap between surgery and RT was 23-198 days (median, 80). Clinically visible residual disease was present in 81 patients (77.1%). Total hysterectomy had been done in 82 patients (78%) and subtotal hysterectomy in 23 patients (22%). The 5-year overall survival, disease-free survival, and pelvic control rates of all patients were 55.2%, 53.3%, and 72.4%, respectively. On univariate analysis, older age, total hysterectomy, hemoglobin level >10 g% before RT, nonsquamous histologic type, use of intracavitary RT, a shorter gap between surgery and RT, and the absence of, or a small volume of, residual disease favorably affected the outcome. The 5-year actuarial rate of late toxicity (Radiation Therapy Oncology Group Criteria) was 19% in the rectum, 4.8% in the bladder, 24.8% in the skin, and 14.3% in the small intestine. Conclusions: Inadequate and inappropriate surgery in invasive cervical cancer with resulting gross residual disease is common in India. Factors such as the use of intracavitary RT, the correction of anemia, and a shorter gap between surgery and RT will enable postoperative RT to achieve acceptable results with minimal morbidity
Clinical analysis of radiotherapy for nasopharyngeal carcinoma in 145 children and adolescents
Objective: To evaluate the clinical characteristics, treatment, outcome and complications of child and adolescent nasopharyngeal carcinoma (NPC). Methods: From January 1970 to April 1997, the records of 145 NPC patients younger than 21 years of age were reviewed. The clinical stages according to 92' Chinese NPC Staging System were: stage I in 1, II in 8, III in 79 and IV in 57. All patients were treated with external beam radiotherapy. Before 1988, parallel opposed lateral pre-auricular portals were chiefly used in 75 patients and after 1988, parallel opposed lateral facio-cervical portals were adopted in 70. The radiation dose to the primary tumor ranged 45-80 Gy: 70 Gy in 50 cases and 32 of them also received chemotherapy. Results: Distant metastasis developed in 26 cases, while local and/or regional recurrence in 14. The actuarial overall survival rates of 1-, 3-, 5 , and 10-years were 96.3%, 79.9%, 76.5% and 69.4%, respectively. Among 45 dead cases, 16 did so of metastasis, 11 of local and/or regional recurrence and 18 of other reasons. Univariate analysis suggested that clinical stage, size and site of involved lymph nodes, skull base involvement were significant prognostic factors of survival, whereas sex, age,dose, therapeutic method and chemotherapy were not. Conclusions: 1. Even though the majority of pediatric and adolescent NPC were advanced , it signifies a relatively good survival. 2. As the normal tissue of pediatric and adolescent patients tolerates radiation poorly, prudence should be meticulously practiced in deciding the radiation dose and radiotherapeutic fields
Kirchheiner, Kathrin, E-mail: kathrin.kirchheiner@meduniwien.ac.at [Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna/General Hospital of Vienna (Austria); Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna (Austria); Nout, Remi A. [Department of Clinical Oncology, Leiden University Medical Center (Netherlands); Tanderup, Kari; Lindegaard, Jacob C. [Department of Oncology, Aarhus University Hospital (Denmark); Westerveld, Henrike [Department of Radiotherapy, Academic Medical Centre, University of Amsterdam (Netherlands); Haie-Meder, Christine [Department of Radiotherapy, Gustave-Roussy, Villejuif (France); Petrič, Primož [Department of Radiotherapy, Institute of Oncology Ljubljana (Slovenia); Department of Radiotherapy, National Center for Cancer Care and Research, Doha (Qatar); Mahantshetty, Umesh [Department of Radiation Oncology, Tata Memorial Hospital, Mumbai (India); Dörr, Wolfgang; Pötter, Richard [Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna/General Hospital of Vienna (Austria); Christian Doppler Laboratory for Medical Radiation Research for Radiation Oncology, Medical University of Vienna (Austria)
2014-05-01
Background and Purpose: Brachytherapy in the treatment of locally advanced cervical cancer has changed substantially because of the introduction of combined intracavitary/interstitial applicators and an adaptive target concept, which is the focus of the prospective, multi-institutional EMBRACE study ( (www.embracestudy.dk)) on image-guided adaptive brachytherapy (IGABT). So far, little has been reported about the development of early to late vaginal morbidity in the frame of IGABT. Therefore, the aim of the present EMBRACE analysis was to evaluate the manifestation pattern of vaginal morbidity during the first 2 years of follow-up. Methods and Materials: In total, 588 patients with a median follow-up time of 15 months and information on vaginal morbidity were included. Morbidity was prospectively assessed at baseline, every 3 months during the first year, and every 6 months in the second year according to the Common Terminology Criteria for Adverse Events, version 3, regarding vaginal stenosis, dryness, mucositis, bleeding, fistula, and other symptoms. Crude incidence rates, actuarial probabilities, and prevalence rates were analyzed. Results: At 2 years, the actuarial probability of severe vaginal morbidity (grade ≥3) was 3.6%. However, mild and moderate vaginal symptoms were still pronounced (grade ≥1, 89%; grade ≥2, 29%), of which the majority developed within 6 months. Stenosis was most frequently observed, followed by vaginal dryness. Vaginal bleeding and mucositis were mainly mild and infrequently reported. Conclusion: Severe vaginal morbidity within the first 2 years after definitive radiation (chemo)therapy including IGABT with intracavitary/interstitial techniques for locally advanced cervical cancer is limited and is significantly less than has been reported from earlier studies. Thus, the new adaptive target concept seems to be a safe treatment with regard to the vagina being an organ at risk. However, mild to moderate vaginal morbidity
Background and Purpose: Brachytherapy in the treatment of locally advanced cervical cancer has changed substantially because of the introduction of combined intracavitary/interstitial applicators and an adaptive target concept, which is the focus of the prospective, multi-institutional EMBRACE study ( (www.embracestudy.dk)) on image-guided adaptive brachytherapy (IGABT). So far, little has been reported about the development of early to late vaginal morbidity in the frame of IGABT. Therefore, the aim of the present EMBRACE analysis was to evaluate the manifestation pattern of vaginal morbidity during the first 2 years of follow-up. Methods and Materials: In total, 588 patients with a median follow-up time of 15 months and information on vaginal morbidity were included. Morbidity was prospectively assessed at baseline, every 3 months during the first year, and every 6 months in the second year according to the Common Terminology Criteria for Adverse Events, version 3, regarding vaginal stenosis, dryness, mucositis, bleeding, fistula, and other symptoms. Crude incidence rates, actuarial probabilities, and prevalence rates were analyzed. Results: At 2 years, the actuarial probability of severe vaginal morbidity (grade ≥3) was 3.6%. However, mild and moderate vaginal symptoms were still pronounced (grade ≥1, 89%; grade ≥2, 29%), of which the majority developed within 6 months. Stenosis was most frequently observed, followed by vaginal dryness. Vaginal bleeding and mucositis were mainly mild and infrequently reported. Conclusion: Severe vaginal morbidity within the first 2 years after definitive radiation (chemo)therapy including IGABT with intracavitary/interstitial techniques for locally advanced cervical cancer is limited and is significantly less than has been reported from earlier studies. Thus, the new adaptive target concept seems to be a safe treatment with regard to the vagina being an organ at risk. However, mild to moderate vaginal morbidity
Decision analysis multicriteria analysis
The ALARA procedure covers a wide range of decisions from the simplest to the most complex one. For the simplest one the engineering judgement is generally enough and the use of a decision aiding technique is therefore not necessary. For some decisions the comparison of the available protection option may be performed from two or a few criteria (or attributes) (protection cost, collective dose,...) and the use of rather simple decision aiding techniques, like the Cost Effectiveness Analysis or the Cost Benefit Analysis, is quite enough. For the more complex decisions, involving numerous criteria or for decisions involving large uncertainties or qualitative judgement the use of these techniques, even the extended cost benefit analysis, is not recommended and appropriate techniques like multi-attribute decision aiding techniques are more relevant. There is a lot of such particular techniques and it is not possible to present all of them. Therefore only two broad categories of multi-attribute decision aiding techniques will be presented here: decision analysis and the outranking analysis
Jinhyun Choi
Full Text Available To analyze the clinical features and prognostic factors associated with the survival of patients with a very rare occurrence of brain metastasis (BM from differentiated thyroid cancer (DTC.A total of 37 patients with DTC who were diagnosed with BM between 1995 and 2014 were included. We reviewed the clinical characteristics, treatment modalities, and image findings of BM. Factors associated with survival were evaluated, and the patients were divided into three prognostic groups (Groups A, B, and C for comparative analysis.The median age at BM was 63 years, and the median time from initial thyroid cancer diagnosis to BM was 3.8 years. The median survival and the 1-year actuarial survival rate after BM were 8.8 months and 47%, respectively. According to univariate and multivariate analyses, four good prognostic factors (GPFs were identified including age ≤ 60 years, PS ≤ ECOG 2, ≤ 3 BM sites, and without extracranial metastasis prior to BM. Three prognostic groups were designed based on age and number of remaining GPFs: patients ≤ 60 years of age with at least 2 GPFs (Group A had the most favorable prognosis with a median survival of 32.8 months; patients ≤ 60 years of age with fewer than 2 GPFs and those > 60 years of age with at least 2 GPFs (Group B had an intermediate prognosis with a median survival of 9.4 months; and patients > 60 years of age with fewer than 2 GPFs (Group C had the least favorable prognosis with a median survival of 1.5 months.The survival of patients with BM form DTC differed among the prognostic groups based on the total number of good prognostic factors.
Choi, Jinhyun; Kim, Jun Won; Keum, Yo Sup; Lee, Ik Jae
2016-01-01
Purpose To analyze the clinical features and prognostic factors associated with the survival of patients with a very rare occurrence of brain metastasis (BM) from differentiated thyroid cancer (DTC). Methods and Materials A total of 37 patients with DTC who were diagnosed with BM between 1995 and 2014 were included. We reviewed the clinical characteristics, treatment modalities, and image findings of BM. Factors associated with survival were evaluated, and the patients were divided into three prognostic groups (Groups A, B, and C) for comparative analysis. Results The median age at BM was 63 years, and the median time from initial thyroid cancer diagnosis to BM was 3.8 years. The median survival and the 1-year actuarial survival rate after BM were 8.8 months and 47%, respectively. According to univariate and multivariate analyses, four good prognostic factors (GPFs) were identified including age ≤ 60 years, PS ≤ ECOG 2, ≤ 3 BM sites, and without extracranial metastasis prior to BM. Three prognostic groups were designed based on age and number of remaining GPFs: patients ≤ 60 years of age with at least 2 GPFs (Group A) had the most favorable prognosis with a median survival of 32.8 months; patients ≤ 60 years of age with fewer than 2 GPFs and those > 60 years of age with at least 2 GPFs (Group B) had an intermediate prognosis with a median survival of 9.4 months; and patients > 60 years of age with fewer than 2 GPFs (Group C) had the least favorable prognosis with a median survival of 1.5 months. Conclusions The survival of patients with BM form DTC differed among the prognostic groups based on the total number of good prognostic factors. PMID:27128487
Primary mediastinal malignancies are uncommon. They can originate from any mediastinal organ or tissue but most commonly arise from thymic, neurogenic, lymphatic, germinal or mesenchymal tissues. The aim of this study was to review the clinical presentations, diagnostic methods adopted, the histologies and the treatment outcomes of this rare subset of tumors. Case records of 91 patients in the period 1993-2006 at our institute were retrospectively analyzed. Patients with primary mediastinal mass and supraclavicular nodes were included for the analysis. Patients with primary, extrathoracic disease of the lung and peripheral adenopathy were excluded. Actuarial method was used for calculating the disease-free survival and overall survival. Primary mediastinal tumors were seen commonly in males with mean age of 37.48 + - 17.04 years. As many as 97% of patients were symptomatic at presentation. Superior venacaval obstruction (SVCO) was seen in 28% of the patients. As many as 50% of the patients were diagnosed by a fine-needle aspiration or Trucut biopsy, while 28% of the patients required thoracotomy for a diagnosis. Majority of the tumors had anterior mediastinal presentation. Pleural effusion was seen in 20% of the patients, but diagnosis was obtained in only 1%. In adults, thymoma (39%), lymphoma (30%) and germ cell tumor (15%) were the common tumors. In the pediatric population, lymphoma, PNET and neuroblastoma were the common tumors. The 5-year DFS and OS are 50% and 55%, respectively. Primary mediastinal tumors are a challenge to the treating physician because of their unique presentation in the form of medical emergencies, like superior venacaval obstruction and stridor. Diagnosis may require invasive procedures like thoracotomy. Treatment and outcome depend on the histologic subtypes. (author)
This textbook deals with instrumental analysis, which consists of nine chapters. It has Introduction of analysis chemistry, the process of analysis and types and form of the analysis, Electrochemistry on basic theory, potentiometry and conductometry, electromagnetic radiant rays and optical components on introduction and application, Ultraviolet rays and Visible spectrophotometry, Atomic absorption spectrophotometry on introduction, flame emission spectrometry and plasma emission spectrometry. The others like infrared spectrophotometry, X-rays spectrophotometry and mass spectrometry, chromatography and the other instrumental analysis like radiochemistry.
2011-04-05
... Form 5500 Annual Return/Report for Pension Plans Electing Funding Alternatives Under Pension Relief Act... defined benefit pension plans under the Preservation of Access to Care for Medicare Beneficiaries and Pension Relief Act of 2010 (Pension Relief Act). The information that would be required either by way...
Devesa Carpio, María del Mar
2007-01-01
RESUMEN Todos los países están mostrando una preocupación creciente por la salud financiera de sus sistemas de pensiones, lo cual se ha traducido en una serie de reformas. Sin embargo, uno de los elementos a los que se le ha prestado menos atención ha sido la deuda implícita de la Seguridad Social; es decir, la cuantía de las obligaciones contraídas por el sistema de Seguridad Social con los trabajadores en activo y con los ya jubilados. Por ello, en primer lugar se va a definir la deud...
Connor-Smith, Jennifer K.; Henning, Kris; Moore, Stephanie; Holdford, Robert
2011-01-01
Recent studies support the validity of both structured risk assessment tools and victim perceptions as predictors of risk for repeat intimate partner violence (IPV). Combining structured risk assessments and victim risk assessments leads to better predictions of repeat violence than either alone, suggesting that the two forms of assessment provide…
Gabel, Jon; Pickreign, Jeremy; McDevitt, Roland; Whitmore, Heidi; Gandolfo, Laura; Lore, Ryan; Wilson, Katy
2007-01-01
Using multiple databases, this paper examines recent trends in the affordability and comprehensiveness of small-group and individual health insurance markets in California. Both became less affordable over the study period. In 2006, a single person age 32-52 earning the median income who purchased individual insurance spent on average 16 percent of income on premiums and out-of-pocket medical expenses. For individual insurance, the share of medical expenses paid by insurance as opposed to patients declined from 2002 to 2006. In the small-group market, premiums rose more than 50 percent from 2003 to 2006, but the proportion of claims paid by insurers for a standardized population remained constant. PMID:17569684
Ricote Gil, Fernando.
2003-01-01
La dependencia es un estado en el que se encuentran las personas que por razones ligadas a la falta o la pérdida de autonomía física, psíquica o intelectual tienen necesidad de asistencia y/o atención significativa para la realización los actos corrientes de la vida diaria. Dentro de la iniciativa privada, el sector asegurador juega un importante papel para la prestación de garantías derivadas de esta cobertura. Un aspecto fundamental en el estudio de esta cobertura es la consideración ...
renal cell and melanoma (100% and 94%). Intracranial recurrence outside the RS volume occurred in 27 pts (22%). The actuarial median survival(MS) from date of RS for all patients was 56 wks, with 1 and 2 year survival rates of 53% and 30%. The actuarial MS with KPS ≥ 70 was 44 wks. 19 of 77 (25%) deaths were attributed to CNS progression. Multivariate analysis revealed two statistically significant predictors of survival: baseline KPS (MS: KPS 100 > 123 wks, KPS 90=54 wks, KPS 70-80=28 wks, p <.0001) and absence of other metastasis (MS: absent=78 wks, present=42 wks, p=.008). Breast cancer patients had the longest survival (MS=115 wks); lung (MS=47 wks) and renal cell (MS=29 wks) had the shortest survival. Two deaths (1.6%) occurred within 30 days of RS, compared to 4% and 9% rates in the surgical arms from Patchell and Noordijk. CONCLUSION: RS followed by WBRT for single BM produces substantial functional survival, especially in pts with high KPS and no other metastasis. These results are similar to randomized trials of surgical resection and WBRT. The advantages of RS over surgery in terms of cost, hospitalization, morbidity, and wider applicability strongly suggest that a randomized trial to compare RS with surgery is warranted
... page: //medlineplus.gov/ency/article/003741.htm Sensitivity analysis To use the sharing features on this page, please enable JavaScript. Sensitivity analysis determines the effectiveness of antibiotics against microorganisms (germs) ...
Gionis, Aristides
2013-01-01
The objective of this report is to highlight opportunities for enhancing global research data infrastructures from the point of view of data analysis. We discuss various directions and data-analysis functionalities for supporting such infrastructures.
Cerebrospinal fluid analysis ... Analysis of CSF can help detect certain conditions and diseases. All of the following can be, but ... An abnormal CSF analysis result may be due to many different causes, ... Encephalitis (such as West Nile and Eastern Equine) Hepatic ...
Kantorovich, L V
1982-01-01
Functional Analysis examines trends in functional analysis as a mathematical discipline and the ever-increasing role played by its techniques in applications. The theory of topological vector spaces is emphasized, along with the applications of functional analysis to applied analysis. Some topics of functional analysis connected with applications to mathematical economics and control theory are also discussed. Comprised of 18 chapters, this book begins with an introduction to the elements of the theory of topological spaces, the theory of metric spaces, and the theory of abstract measure space
The neutron activation analysis, which appears to be in limits for further advance, is the most suitable for providing information on the principal as well as the microcomponents in any sample of solid form. Then, instrumental activation analysis is capable of determination of far many elements in various samples. Principally on the neutron activation analysis, the following are described in literature survey from 1982 to middle 1984: bibliography, review, data collection, etc.; problems in spectral analysis and measurement; activation analysis with neutrons; charged particle and photo-nucleus reactions; chemical separation, isotopic dilution activation analysis; molecular activation analysis; standard materials; life and its relation samples; environmental, food, court trial and archaeological samples; space and earth sciences. (Mori, K.)
An Analysis of Farmers' Insurance Choices and Federal Crop Insurance Subsidies
Feng, Hongli; Du, Xiaodong; David A. Hennessy
2013-01-01
The U.S. crop insurance has two distinct features that set itself apart from insurance in other areas: (i) it is explicitly subsidized with an average premium subsidy rate of about 60 percent in recent years; and (ii) the law requires the premium rate be set at actuarially fair level with the federal government paying the administrative and operational costs related to the sale and service of insurance policies. Bearing in mind these features, we examine to what extent farmers’ crop insurance...
Analysis of Pension Schemes Disclosures of UK - FTSE 100 Companies 2005-2006
Sun, Yulu
2007-01-01
This study aims to examine the level and quality of disclosures with regard to pension obligations, with particular focus on principal actuarial assumptions among the FTSE 100 companies under IFRS and UK GAAP in 2005 and 2006. The increasing risks behind the pension liabilities have highlighted the need for more informative and accurate pension disclosures. Investors need more information on pensions in order to understand the underlying risks and adjust their investment decisions accordi...
Purpose: Lymph node status is an important predictor of survival in pancreatic cancer. We performed a secondary analysis of Radiation Therapy Oncology Group (RTOG) 9704, an adjuvant chemotherapy and chemoradiation trial, to determine the influence of lymph node factors—number of positive nodes (NPN), total nodes examined (TNE), and lymph node ratio (LNR ratio of NPN to TNE)—on OS and disease-free survival (DFS). Patient and Methods: Eligible patients from RTOG 9704 form the basis of this secondary analysis of lymph node parameters. Actuarial estimates for OS and DFS were calculated using Kaplan-Meier methods. Cox proportional hazards models were performed to evaluate associations of NPN, TNE, and LNR with OS and DFS. Multivariate Cox proportional hazards models were also performed. Results: There were 538 patients enrolled in the RTOG 9704 trial. Of these, 445 patients were eligible with lymph nodes removed. Overall median NPN was 1 (min-max, 0–18). Increased NPN was associated with worse OS (HR = 1.06, p = 0.001) and DFS (HR = 1.05, p = 0.01). In multivariate analyses, both NPN and TNE were associated with OS and DFS. TNE > 12, and >15 were associated with increased OS for all patients, but not for node-negative patients (n = 142). Increased LNR was associated with worse OS (HR = 1.01, p < 0.0001) and DFS (HR = 1.006, p = 0.002). Conclusion: In patients who undergo surgical resection followed by adjuvant chemoradiation, TNE, NPN, and LNR are associated with OS and DFS. This secondary analysis of a prospective, cooperative group trial supports the influence of these lymph node parameters on outcomes after surgery and adjuvant therapy using contemporary techniques.
Showalter, Timothy N. [Department of Radiation Oncology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA (United States); Winter, Kathryn A. [Radiation Therapy Oncology Group, RTOG Statistical Center, Philadelphia, PA (United States); Berger, Adam C., E-mail: adam.berger@jefferson.edu [Department of Surgery, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA (United States); Regine, William F. [Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, MD (United States); Abrams, Ross A. [Department of Radiation Oncology, Rush University Medical Center, Chicago, IL (United States); Safran, Howard [Department of Medicine, Miriam Hospital, Brown University Oncology Group, Providence, RI (United States); Hoffman, John P. [Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA (United States); Benson, Al B. [Division of Hematology-Oncology, Northwestern University, Chicago, IL (United States); MacDonald, John S. [St. Vincent' s Cancer Care Center, New York, NY (United States); Willett, Christopher G. [Department of Radiation Oncology, Duke University Medical Center, Durham, NC (United States)
2011-12-01
Purpose: Lymph node status is an important predictor of survival in pancreatic cancer. We performed a secondary analysis of Radiation Therapy Oncology Group (RTOG) 9704, an adjuvant chemotherapy and chemoradiation trial, to determine the influence of lymph node factors-number of positive nodes (NPN), total nodes examined (TNE), and lymph node ratio (LNR ratio of NPN to TNE)-on OS and disease-free survival (DFS). Patient and Methods: Eligible patients from RTOG 9704 form the basis of this secondary analysis of lymph node parameters. Actuarial estimates for OS and DFS were calculated using Kaplan-Meier methods. Cox proportional hazards models were performed to evaluate associations of NPN, TNE, and LNR with OS and DFS. Multivariate Cox proportional hazards models were also performed. Results: There were 538 patients enrolled in the RTOG 9704 trial. Of these, 445 patients were eligible with lymph nodes removed. Overall median NPN was 1 (min-max, 0-18). Increased NPN was associated with worse OS (HR = 1.06, p = 0.001) and DFS (HR = 1.05, p = 0.01). In multivariate analyses, both NPN and TNE were associated with OS and DFS. TNE > 12, and >15 were associated with increased OS for all patients, but not for node-negative patients (n = 142). Increased LNR was associated with worse OS (HR = 1.01, p < 0.0001) and DFS (HR = 1.006, p = 0.002). Conclusion: In patients who undergo surgical resection followed by adjuvant chemoradiation, TNE, NPN, and LNR are associated with OS and DFS. This secondary analysis of a prospective, cooperative group trial supports the influence of these lymph node parameters on outcomes after surgery and adjuvant therapy using contemporary techniques.
Bishop, Andrew J.; Tao, Randa [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Rebueno, Neal C. [Department of Radiation Dosimetry, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Christensen, Eva N.; Allen, Pamela K. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Wang, Xin A. [Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Amini, Behrang [Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Tannir, Nizar M. [Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Tatsui, Claudio E.; Rhines, Laurence D. [Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Li, Jing [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Chang, Eric L. [Department of Radiation Oncology, USC Norris Cancer Hospital, Keck School of Medicine of USC, Los Angeles, California (United States); Brown, Paul D. [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Ghia, Amol J., E-mail: ajghia@mdanderson.org [Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas (United States)
2015-08-01
Purpose: To investigate local control, survival outcomes, and predictors of local relapse for patients treated with spine stereotactic body radiation therapy. Methods and Materials: We reviewed the records of 332 spinal metastases consecutively treated with stereotactic body radiation therapy between 2002 and 2012. The median follow-up for all living patients was 33 months (range, 0-111 months). Endpoints were overall survival and local control (LC); recurrences were classified as either in-field or marginal. Results: The 1-year actuarial LC and overall survival rates were 88% and 64%, respectively. Patients with local relapses had poorer dosimetric coverage of the gross tumor volume (GTV) compared with patients without recurrence (minimum dose [Dmin] biologically equivalent dose [BED] 23.9 vs 35.1 Gy, P<.001; D98 BED 41.8 vs 48.1 Gy, P=.001; D95 BED 47.2 vs 50.5 Gy, P=.004). Furthermore, patients with marginal recurrences had poorer prescription coverage of the GTV (86% vs 93%, P=.01) compared with those with in-field recurrences, potentially because of more upfront spinal canal disease (78% vs 24%, P=.001). Using a Cox regression univariate analysis, patients with a GTV BED Dmin ≥33.4 Gy (median dose) (equivalent to 14 Gy in 1 fraction) had a significantly higher 1-year LC rate (94% vs 80%, P=.001) compared with patients with a lower GTV BED Dmin; this factor was the only significant variable on multivariate Cox analysis associated with LC (P=.001, hazard ratio 0.29, 95% confidence interval 0.14-0.60) and also was the only variable significant in a separate competing risk multivariate model (P=.001, hazard ratio 0.30, 95% confidence interval 0.15-0.62). Conclusions: Stereotactic body radiation therapy offers durable control for spinal metastases, but there is a subset of patients that recur locally. Patients with local relapse had significantly poorer tumor coverage, which was likely attributable to treatment planning directives that prioritized the
Purpose: To investigate local control, survival outcomes, and predictors of local relapse for patients treated with spine stereotactic body radiation therapy. Methods and Materials: We reviewed the records of 332 spinal metastases consecutively treated with stereotactic body radiation therapy between 2002 and 2012. The median follow-up for all living patients was 33 months (range, 0-111 months). Endpoints were overall survival and local control (LC); recurrences were classified as either in-field or marginal. Results: The 1-year actuarial LC and overall survival rates were 88% and 64%, respectively. Patients with local relapses had poorer dosimetric coverage of the gross tumor volume (GTV) compared with patients without recurrence (minimum dose [Dmin] biologically equivalent dose [BED] 23.9 vs 35.1 Gy, P<.001; D98 BED 41.8 vs 48.1 Gy, P=.001; D95 BED 47.2 vs 50.5 Gy, P=.004). Furthermore, patients with marginal recurrences had poorer prescription coverage of the GTV (86% vs 93%, P=.01) compared with those with in-field recurrences, potentially because of more upfront spinal canal disease (78% vs 24%, P=.001). Using a Cox regression univariate analysis, patients with a GTV BED Dmin ≥33.4 Gy (median dose) (equivalent to 14 Gy in 1 fraction) had a significantly higher 1-year LC rate (94% vs 80%, P=.001) compared with patients with a lower GTV BED Dmin; this factor was the only significant variable on multivariate Cox analysis associated with LC (P=.001, hazard ratio 0.29, 95% confidence interval 0.14-0.60) and also was the only variable significant in a separate competing risk multivariate model (P=.001, hazard ratio 0.30, 95% confidence interval 0.15-0.62). Conclusions: Stereotactic body radiation therapy offers durable control for spinal metastases, but there is a subset of patients that recur locally. Patients with local relapse had significantly poorer tumor coverage, which was likely attributable to treatment planning directives that prioritized the
Bartuňková, Alena
2008-01-01
The objective of this Bachelor thesis is to carry out a strategic analysis of a Czech owned limited company, Česky národní podnik s.r.o. This company sells traditional Czech products and manufactures cosmetics and body care products. The first part of the thesis provides theoretical background and methodology that are used later for the strategic analysis of the company. The theory outlined in this paper is based on the analysis of external and internal factors. Firstly the PEST analysis has ...
Chládek, Vítězslav
2012-01-01
The objective of this Bachelor thesis is to carry out a strategic analysis of a Czech owned limited company, Česky národní podnik s.r.o. This company sells traditional Czech products and manufactures cosmetics and body care products. The first part of the thesis provides theoretical background and methodology that are used later for the strategic analysis of the company. The theory outlined in this paper is based on the analysis of external and internal factors. Firstly the PEST analysis has ...
Aims and background. To describe feasibility, tolerability and clinical outcomes of stereotactic body radiation therapy (SBRT) in the treatment of adrenal metastases in 34 consecutive cancer patients. Material and methods. Between March 2004 and July 2010, a total of 34 consecutive patients, accounting for 36 adrenal metastatic lesions, were treated with SBRT. SBRT treatments were delivered by a Linac Varian 600 with microMLC (3DLine, Elekta, Stockholm, Sweden) and a Linac ELEKTA Precise (Elekta). All 34 patients were clinically and radiologically evaluated during and after completion of SBRT. Following outcomes were taken into account: best clinical response at any time, local control, time to systemic progression, time to local progression, overall survival and toxicity. Survival was estimated by the Kaplan-Meier method and factor potentially affecting outcomes were analyzed with Cox regression analysis. Results. Total RT doses ranged from 20 Gy in 4 fractions to 45 Gy in 18 fractions (median dose: 32 Gy; median number of fractions: 4). All doses were prescribed to the 95% isodose line. No cases of Grade ≥ 3 toxicity were recorded. At a median follow-up time of 41 months (range, 12-75) 22 patients were alive. Three of 28 lesions (11%) showed complete response, 13/28 (46%) partial response, 10/28 (36%) stable disease and 2/28 (7%) progressed in the treated area. Local failure was observed in 13 cases. Actuarial local control rates at one and two years were 66% and 32%, respectively. Median time to local progression was 19 months. Median survival was 22 months. Conclusion. SBRT in adrenal gland metastasis is feasible without significant acute and late toxicities, with a good rate of local control. New SBRT fractionation schemes and the possibility to combine new systemic approaches should be investigated in order to further increase local control and reduce systemic disease progression
Li, L.; Braat, L.C.; Lei, G.; Arets, E.J.M.M.; Liu, J.; Jiang, L.; Fan, Z.; Liu, W.; He, H.; Sun, X.
2014-01-01
This chapter presents the results of the scenario analysis of China’s ecosystems focusing on forest, grassland, and wetland ecosystems. The analysis was undertaken using Conversion of Land Use Change and its Effects (CLUE) modeling and an ecosystem service matrix (as explained below) complemented by
Lanczos, Cornelius
2010-01-01
Basic text for graduate and advanced undergraduate deals with search for roots of algebraic equations encountered in vibration and flutter problems and in those of static and dynamic stability. Other topics devoted to matrices and eigenvalue problems, large-scale linear systems, harmonic analysis and data analysis, more.
We undertook a study programme at the end of 1991. To start with, we performed some exploratory studies aimed at learning some preliminary lessons on this type of analysis: Assessment of the interest of probabilistic incident analysis; possibility of using PSA scenarios; skills and resources required. At the same time, EPN created a working group whose assignment was to define a new approach for analysis of incidents on NPPs. This working group gave thought to both aspects of Operating Feedback that EPN wished to improve: Analysis of significant incidents; analysis of potential consequences. We took part in the work of this group, and for the second aspects, we proposed a method based on an adaptation of the event-tree method in order to establish a link between existing PSA models and actual incidents. Since PSA provides an exhaustive database of accident scenarios applicable to the two most common types of units in France, they are obviously of interest for this sort of analysis. With this method we performed some incident analyses, and at the same time explores some methods employed abroad, particularly ASP (Accident Sequence Precursor, a method used by the NRC). Early in 1994 EDF began a systematic analysis programme. The first, transient phase will set up methods and an organizational structure. 7 figs
Factor Analysis via Components Analysis
Bentler, Peter M.; de Leeuw, Jan
2011-01-01
When the factor analysis model holds, component loadings are linear combinations of factor loadings, and vice versa. This interrelation permits us to define new optimization criteria and estimation methods for exploratory factor analysis. Although this article is primarily conceptual in nature, an illustrative example and a small simulation show…
78 FR 25135 - Submission for OMB Review; Comment Request
2013-04-29
... currently approved collection. Title: Regulations Governing the Performance of Actuarial Services under the... Enrollment of Actuaries to perform actuarial services under the Employee Retirement Income Security Act...
Khabaza, I M
1960-01-01
Numerical Analysis is an elementary introduction to numerical analysis, its applications, limitations, and pitfalls. Methods suitable for digital computers are emphasized, but some desk computations are also described. Topics covered range from the use of digital computers in numerical work to errors in computations using desk machines, finite difference methods, and numerical solution of ordinary differential equations. This book is comprised of eight chapters and begins with an overview of the importance of digital computers in numerical analysis, followed by a discussion on errors in comput
Brænder, Morten; Andersen, Lotte Bøgh
2014-01-01
Based on our 2013-article, ”Does Deployment to War Affect Soldiers' Public Service Motivation – A Panel Study of Soldiers Before and After their Service in Afghanistan”, we present Panel Analysis as a methodological discipline. Panels consist of multiple units of analysis, observed at two or more...... in research settings where it is not possible to distribute units of analysis randomly or where the independent variables cannot be manipulated. The greatest disadvantage in regard to using panel studies is that data may be difficult to obtain. This is most clearly vivid in regard to the use of panel surveys...
Tan, Qingming
2011-01-01
Dimensional analysis is an essential scientific method and a powerful tool for solving problems in physics and engineering. This book starts by introducing the Pi Theorem, which is the theoretical foundation of dimensional analysis. It also provides ample and detailed examples of how dimensional analysis is applied to solving problems in various branches of mechanics. The book covers the extensive findings on explosion mechanics and impact dynamics contributed by the author's research group over the past forty years at the Chinese Academy of Sciences. The book is intended for advanced undergra
Goodstein, R L
2010-01-01
Recursive analysis develops natural number computations into a framework appropriate for real numbers. This text is based upon primary recursive arithmetic and presents a unique combination of classical analysis and intuitional analysis. Written by a master in the field, it is suitable for graduate students of mathematics and computer science and can be read without a detailed knowledge of recursive arithmetic.Introductory chapters on recursive convergence and recursive and relative continuity are succeeded by explorations of recursive and relative differentiability, the relative integral, and
Postoperative radiotherapy for endometrial carcinoma. A retrospective analysis of 541 cases
Purpose: This retrospective study was designed to evaluate the role of adjuvant radiotherapy for surgically treated endometrial carcinoma. Patients and methods: From 1980 through 1988, 541 patients were treated with either intravaginal cuff irradiation with a high-dose-rate (HDR) Iridium-192 remote afterloading technique (n=294) or with combined HDR-brachytherapy and additional external pelvic irradiation to 54 Gy (n=247) after surgery for endometrical cancer. Afterloading irradiation was administered in 4 fractions 4 to 6 weeks after surgery. A dose of 30 Gy was delivered at a depth of 0,5 cm from the vaginal mucosa. Results: Patients with HDR-brachytherapy alone showed a 5-year survival of 94.3% for Stage I and 73.6% for Stage II (p=0.0007). Patients who received both brachytherapy and additional pelvic irradiation had a 5-year survival of 94.1% for Stage I, 81.1% for Stage II, 70.4% for Stage III and 46.9% for Stage IV (p=0.0001). The main predictors for survival in a multivariate analysis were stage and grading. Patients with combined readiotherapy had a local recurrence rate of 3.2%, whereas patients with brachytherapy alone who were better selected and had more favorable prognostic factors showed a recurrence rate of 2%. Low-risk patients (Stage I, Grade 1, low infiltration) in the HDR-brachytherapy group had 6 relapses, mainly caused by insufficient treatment on the basis of papillary histology. High-risk patients with poorly differential tumors, which infiltrate more than half the myometrial wall might benefit from additional external radiotherapy in terms of reduction of local recurrence and better survival. Five-year actuarial survival rate was 93.6% after combined radiotherapy vs 86.7% after brachytherapy alone. Complications were graded according to the RTOG scoring system. Severe late complications were fistulas of bladder and/or bowel, which occurred in 2.8% in the combined radiotherapy group, and 0.7% in the HDR brachytherapy group. (orig.)
Tao, Terence
2016-01-01
This is part one of a two-volume book on real analysis and is intended for senior undergraduate students of mathematics who have already been exposed to calculus. The emphasis is on rigour and foundations of analysis. Beginning with the construction of the number systems and set theory, the book discusses the basics of analysis (limits, series, continuity, differentiation, Riemann integration), through to power series, several variable calculus and Fourier analysis, and then finally the Lebesgue integral. These are almost entirely set in the concrete setting of the real line and Euclidean spaces, although there is some material on abstract metric and topological spaces. The book also has appendices on mathematical logic and the decimal system. The entire text (omitting some less central topics) can be taught in two quarters of 25–30 lectures each. The course material is deeply intertwined with the exercises, as it is intended that the student actively learn the material (and practice thinking and writing ri...
Tao, Terence
2016-01-01
This is part two of a two-volume book on real analysis and is intended for senior undergraduate students of mathematics who have already been exposed to calculus. The emphasis is on rigour and foundations of analysis. Beginning with the construction of the number systems and set theory, the book discusses the basics of analysis (limits, series, continuity, differentiation, Riemann integration), through to power series, several variable calculus and Fourier analysis, and then finally the Lebesgue integral. These are almost entirely set in the concrete setting of the real line and Euclidean spaces, although there is some material on abstract metric and topological spaces. The book also has appendices on mathematical logic and the decimal system. The entire text (omitting some less central topics) can be taught in two quarters of 25–30 lectures each. The course material is deeply intertwined with the exercises, as it is intended that the student actively learn the material (and practice thinking and writing ri...
2016-06-01
Fact sheet summarizing NREL's techno-economic analysis and life-cycle assessment capabilities to connect research with future commercial process integration, a critical step in the scale-up of biomass conversion technologies.
Donoho, Steve
Link analysis is a collection of techniques that operate on data that can be represented as nodes and links. This chapter surveys a variety of techniques including subgraph matching, finding cliques and K-plexes, maximizing spread of influence, visualization, finding hubs and authorities, and combining with traditional techniques (classification, clustering, etc). It also surveys applications including social network analysis, viral marketing, Internet search, fraud detection, and crime prevention.
Graffelman, Jan
2013-01-01
Factor analysis is a multivariate statistical method for data reduction that originated in psychometrics and has found applications in many branches of science. The method aims to describe the correlation structure between a large set of observed variables in terms of a few underlying latent variables called factors. Factor analysis employs a specific model, where observed variables are modelled as linear combinations of common factors plus a specific error term. This model can be estimated b...
Gorsuch, Richard L
2013-01-01
Comprehensive and comprehensible, this classic covers the basic and advanced topics essential for using factor analysis as a scientific tool in psychology, education, sociology, and related areas. Emphasizing the usefulness of the techniques, it presents sufficient mathematical background for understanding and sufficient discussion of applications for effective use. This includes not only theory but also the empirical evaluations of the importance of mathematical distinctions for applied scientific analysis.
Paul, Debra; Cadle, James
2010-01-01
Throughout the business world, public, private and not-for-profit organisations face huge challenges. Business analysts must respond by developing practical, creative and financially sound solutions. This excellent guide gives them the necessary tools. It supports everyone wanting to achieve university and industry qualifications in business analysis and information systems. It is particularly beneficial for those studying for ISEB qualifications in Business Analysis. Some important additions since the first edition (2006): the inclusion of new techniques such as Ishikawa diagrams and spaghe
Scott, L Ridgway
2011-01-01
Computational science is fundamentally changing how technological questions are addressed. The design of aircraft, automobiles, and even racing sailboats is now done by computational simulation. The mathematical foundation of this new approach is numerical analysis, which studies algorithms for computing expressions defined with real numbers. Emphasizing the theory behind the computation, this book provides a rigorous and self-contained introduction to numerical analysis and presents the advanced mathematics that underpin industrial software, including complete details that are missing from m
Radioactivation analysis is the technique of radioactivation analysis of the constituents of a very small sample of matter by making the sample artificially radioactive. The first stage is to make the sample radioactive by artificial means, e.g. subject it to neutron bombardment. Once the sample has been activated, or made radioactive, the next task is to analyze the radiations given off by the sample. This analysis would indicate the nature and quantities of the various elements present in the sample. The reason is that the radiation from a particular radioisotope. In 1959 a symposium on 'Radioactivation Analysis' was organized in Vienna by the IAEA and the Joint Commission on Applied Radioactivity (ICSU). It was pointed out that there are certain factors creating uncertainties and elaborated how to overcome them. Attention was drawn to the fact that radioactivation analysis had proven a powerful tool tackling fundamental problems in geo- and cosmochemistry, and a review was given of the recent work in this field. Because of its extreme sensitivity radioactivation analysis had been principally employed for trace detection and its most extensive use has been in control of semiconductors and very pure metals. An account of the experience gained in the USA was given, where radioactivation analysis was being used by many investigators in various scientific fields as a practical and useful tool for elemental analyses. Much of this work had been concerned with determining sub microgramme and microgramme concentration of many different elements in samples of biological materials, drugs, fertilizers, fine chemicals, foods, fuels, glass, ceramic materials, metals, minerals, paints, petroleum products, resinous materials, soils, toxicants, water and other materials. In addition to these studies, radioactivation analysis had been used by other investigators to determine isotopic ratios of the stable isotopes of some of the elements. Another paper dealt with radioactivation
Loeb, Peter A
2016-01-01
This textbook is designed for a year-long course in real analysis taken by beginning graduate and advanced undergraduate students in mathematics and other areas such as statistics, engineering, and economics. Written by one of the leading scholars in the field, it elegantly explores the core concepts in real analysis and introduces new, accessible methods for both students and instructors. The first half of the book develops both Lebesgue measure and, with essentially no additional work for the student, general Borel measures for the real line. Notation indicates when a result holds only for Lebesgue measure. Differentiation and absolute continuity are presented using a local maximal function, resulting in an exposition that is both simpler and more general than the traditional approach. The second half deals with general measures and functional analysis, including Hilbert spaces, Fourier series, and the Riesz representation theorem for positive linear functionals on continuous functions with compact support....
Jacques, Ian
1987-01-01
This book is primarily intended for undergraduates in mathematics, the physical sciences and engineering. It introduces students to most of the techniques forming the core component of courses in numerical analysis. The text is divided into eight chapters which are largely self-contained. However, with a subject as intricately woven as mathematics, there is inevitably some interdependence between them. The level of difficulty varies and, although emphasis is firmly placed on the methods themselves rather than their analysis, we have not hesitated to include theoretical material when we consider it to be sufficiently interesting. However, it should be possible to omit those parts that do seem daunting while still being able to follow the worked examples and to tackle the exercises accompanying each section. Familiarity with the basic results of analysis and linear algebra is assumed since these are normally taught in first courses on mathematical methods. For reference purposes a list of theorems used in the t...
Purpose: Induction chemotherapy has been proposed in the case of advanced laryngeal cancer in order to preserve laryngeal function in those patients who are complete responders. To clarify the treatment policies, a retrospective multicentric analysis of 116 patients with advanced carcinoma of the larynx treated by radical surgery and postoperative radiotherapy was carried out in order to evaluate prognostic factors for local control and survival. Methods and Materials: Between 1980 and 1985, 116 patients with Stage III squamous cell carcinoma of the larynx underwent radical surgery and postoperative radiotherapy with a curative intent. Treatments were very homogenous, and doses delivered were in the range of 50-65 Gy according to nodal involvement and surgical margins status. Results: The local recurrence rate and the local disease-free survival rate at 5 years were 22.5% and 76.3%, respectively. Actuarial survival at 5 years was 68.3% with 44 patients still alive with no evidence of disease (NED) with more than 5 years follow-up. For both overall survival and relapse-free survival, cervical node involvement with capsular rupture was found to be the only significant adverse pronostic factor in univariate and multivariate analysis. No other parameter was predictive either for local recurrence or for survival. Conclusions: Local prognosis and survival depend largely on nodal involvement and capsular rupture while increasing doses of radiation strategy is likely to reduce the risk of local and nodal recurrence. Preservation of functional larynx is certainly an important goal to achieve when treating advanced carcinoma of the larynx, provided that local failure rate and survival be similar. In the unique randomized study previously published in the literature comparing radical surgery and postoperative radiotherapy to induction chemotherapy and radiotherapy, the local-regional failure rate was drastically increased in the chemotherapy arm. Other results from well
Purpose: When irradiating a tumor that abuts or displaces any normal structures, the dose constraints to those structures (if lower than the prescribed dose) may cause dose inhomogeneity in the tumor volume at the tumor-critical structure interface. The low-dose region in the tumor volume may be one of the reasons for local failure. The aim of this study is to quantitate the effect of tumor dose inhomogeneity on local control and recurrence-free survival in patients with skull base chordoma. Methods and Materials: 132 patients with skull base chordoma were treated with combined photon and proton irradiation between 1978 and 1993. This study reviews 115 patients whose dose-volume data and follow-up data are available. The prescribed doses ranged from 66.6 Cobalt-Gray-Equivalent (CGE) to 79.2 CGE (median of 68.9 CGE). The dose to the optic structures (optic nerves and chiasma), the brain stem surface, and the brain stem center was limited to 60, 64, and 53 CGE, respectively. We used the dose-volume histogram data derived with the three-dimensional treatment planning system to evaluate several dose-volume parameters including the Equivalent Uniform Dose (EUD). We also analyzed several other patient and treatment factors in relation to local control and recurrence-free survival. Results: Local failure developed in 42 of 115 patients, with the actuarial local control rates at 5 and 10 years being 59% and 44%. Gender was a significant predictor for local control with the prognosis in males being significantly better than that in females (P 0.004, hazard ratio = 2.3). In a Cox univariate analysis, with stratification by gender, the significant predictors for local control (at the probability level of 0.05) were EUD, the target volume, the minimum dose, and the D5cc dose. The prescribed dose, histology, age, the maximum dose, the mean dose, the median dose, the D90% dose, and the overall treatment time were not significant factors. In a Cox multivariate analysis, the
Brezinski, C
2012-01-01
Numerical analysis has witnessed many significant developments in the 20th century. This book brings together 16 papers dealing with historical developments, survey papers and papers on recent trends in selected areas of numerical analysis, such as: approximation and interpolation, solution of linear systems and eigenvalue problems, iterative methods, quadrature rules, solution of ordinary-, partial- and integral equations. The papers are reprinted from the 7-volume project of the Journal of Computational and Applied Mathematics on '/homepage/sac/cam/na2000/index.html<
Aggarwal, Charu C
2013-01-01
With the increasing advances in hardware technology for data collection, and advances in software technology (databases) for data organization, computer scientists have increasingly participated in the latest advancements of the outlier analysis field. Computer scientists, specifically, approach this field based on their practical experiences in managing large amounts of data, and with far fewer assumptions- the data can be of any type, structured or unstructured, and may be extremely large.Outlier Analysis is a comprehensive exposition, as understood by data mining experts, statisticians and
Snell, K S; Langford, W J; Maxwell, E A
1966-01-01
Elementary Analysis, Volume 2 introduces several of the ideas of modern mathematics in a casual manner and provides the practical experience in algebraic and analytic operations that lays a sound foundation of basic skills. This book focuses on the nature of number, algebraic and logical structure, groups, rings, fields, vector spaces, matrices, sequences, limits, functions and inverse functions, complex numbers, and probability. The logical structure of analysis given through the treatment of differentiation and integration, with applications to the trigonometric and logarithmic functions, is
Cluster analysis is the name of group of multivariate techniques whose principal purpose is to distinguish similar entities from the characteristics they process.To study this analysis, there are several algorithms that can be used. Therefore, this topic focuses to discuss the algorithms, such as, similarity measures, and hierarchical clustering which includes single linkage, complete linkage and average linkage method. also, non-hierarchical clustering method, which is popular name K-mean method' will be discussed. Finally, this paper will be described the advantages and disadvantages of every methods
The 19th Scandinavian Conference on Image Analysis was held at the IT University of Copenhagen in Denmark during June 15-17, 2015. The SCIA conference series has been an ongoing biannual event for more than 30 years and over the years it has nurtured a world-class regional research and development....... The topics of the accepted papers range from novel applications of vision systems, pattern recognition, machine learning, feature extraction, segmentation, 3D vision, to medical and biomedical image analysis. The papers originate from all the Scandinavian countries and several other European countries...
Rockafellar, Ralph Tyrell
2015-01-01
Available for the first time in paperback, R. Tyrrell Rockafellar's classic study presents readers with a coherent branch of nonlinear mathematical analysis that is especially suited to the study of optimization problems. Rockafellar's theory differs from classical analysis in that differentiability assumptions are replaced by convexity assumptions. The topics treated in this volume include: systems of inequalities, the minimum or maximum of a convex function over a convex set, Lagrange multipliers, minimax theorems and duality, as well as basic results about the structure of convex sets and
Everitt, Brian S; Leese, Morven; Stahl, Daniel
2011-01-01
Cluster analysis comprises a range of methods for classifying multivariate data into subgroups. By organizing multivariate data into such subgroups, clustering can help reveal the characteristics of any structure or patterns present. These techniques have proven useful in a wide range of areas such as medicine, psychology, market research and bioinformatics.This fifth edition of the highly successful Cluster Analysis includes coverage of the latest developments in the field and a new chapter dealing with finite mixture models for structured data.Real life examples are used throughout to demons
Steuding, Jorn
2005-01-01
While its roots reach back to the third century, diophantine analysis continues to be an extremely active and powerful area of number theory. Many diophantine problems have simple formulations, they can be extremely difficult to attack, and many open problems and conjectures remain. Diophantine Analysis examines the theory of diophantine approximations and the theory of diophantine equations, with emphasis on interactions between these subjects. Beginning with the basic principles, the author develops his treatment around the theory of continued fractions and examines the classic theory, inclu
This book contains a selection of research works performed in the CEDIAC Institute (Cuyo National University) in the area of Risk Analysis, with specific orientations to the subjects of uncertainty and sensitivity studies, software reliability, severe accident modeling, etc. This volume presents important material for all those researches who want to have an insight in the risk analysis field, as a tool to solution several problems frequently found in the engineering and applied sciences field, as well as for the academic teachers who want to keep up to date, including the new developments and improvements continuously arising in this field
This paper presents the criteria, previous nuclear experience in space, analysis techniques, and possible breakup enhancement devices applicable to an acceptable SP-100 reentry from space. Reactor operation in nuclear-safe orbit will minimize the radiological risk; the remaining safeguards criteria need to be defined. A simple analytical point mass reentry technique and a more comprehensive analysis method that considers vehicle dynamics and orbit insertion malfunctions are presented. Vehicle trajectory, attitude, and possible breakup enhancement devices will be integrated in the simulation as required to ensure an adequate representation of the reentry process
To evaluate the tolerance of neurovascular structures to brachytherapy, a retrospective review of our series was undertaken. Between May 1986 and January 1994, 85 patients with soft tissue sarcomas underwent conservative surgery and low-dose rate interstitial irradiation. Thirty-eight patients had tumors extending to neurovascular structures. Brachytherapy was part of initial treatment in 30 patients and was done in 7 cases for recurrent sarcomas. Afterloading catethers for brachytherapy were inserted intraoperatively and placed direct upon or under the neurovascular structures in the tumor bed. A mean dose of 20 Gy was delivered to the target volume. Thirty patients received 45 to 50 Gy of postoperative external irradiation. With a median follow-up of 39 months, the 3-year actuarial survival was 82.9%, the 3-year disease-free survival was 71.9% and the 3-year actuarial local control was 91%. The 3-year actuarial incidence of distant metastase was 28%. Acute side effects occurred in 12 patients requiring conservative surgical procedures in 6 cases. Significant late toxicity occurred in 8 patients : 2 lymphoedemas interfering with normal activity, 1 partial artery stenosis, 5 peripheral neuropathy (2 grade 2, 3 grade 3). Late toxicity has led to significant impairment of mobility in 4 patients. Limb preservation was achieved in every patient, no amputation was required. We conclude that integration of brachytherapy in the conservative treatment of soft tissue sarcomas extending to neurovascular structures can provide excellent local control with an acceptable level of toxicity
Song Xuexia
2005-01-01
@@ In the past, more attempts had been made to explore the ways for teachers to teach English but fewer for learners to learn the language. Learner analysis is to analyze "What the learner is", including age, attitude, motivation, intelligence,aptitude, personality , and etc, with the purpose to realize the transition from "teacher-centered" into "learner-oriented".
Koornneef, M.; Alonso-Blanco, C.; Stam, P.
2006-01-01
The Mendelian analysis of genetic variation, available as induced mutants or as natural variation, requires a number of steps that are described in this chapter. These include the determination of the number of genes involved in the observed trait's variation, the determination of dominance relation
David P. MacKinnon; Fairchild, Amanda J.; Fritz, Matthew S.
2007-01-01
Mediating variables are prominent in psychological theory and research. A mediating variable transmits the effect of an independent variable on a dependent variable. Differences between mediating variables and confounders, moderators, and covariates are outlined. Statistical methods to assess mediation and modern comprehensive approaches are described. Future directions for mediation analysis are discussed.
Dovjak, M.; Simone, Angela; Kolarik, Jakub;
2011-01-01
Exergy analysis enables us to make connections among processes inside the human body and processes in a building. So far, only the effect of different combinations of air temperatures and mean radiant temperatures have been studied, with constant relative humidity in experimental conditions...
Nielsen, Kirsten
2010-01-01
The first part of this article presents the characteristics of Hebrew poetry: features associated with rhythm and phonology, grammatical features, structural elements like parallelism, and imagery and intertextuality. The second part consists of an analysis of Psalm 121. It is argued that assonance...
Assaf, A. George; Josiassen, Alexander
2016-01-01
and macro applications of these approaches, summarizing and critically reviewing the characteristics of the existing studies. We also conduct a meta-analysis to create an overview of the efficiency results of frontier applications. This allows for an investigation of the impact of frontier methodology...
The objectives of this paper are to: Provide a realistic assessment of consequences; Account for plant and site-specific characteristics; Adjust accident release characteristics to account for results of plant-containment analysis; Produce conditional risk curves for each of five health effects; and Estimate uncertainties
Moore, R; Brødsgaard, I; Miller, ML;
1997-01-01
consistency in use of descriptors within groups, validity of description, accuracy of individuals compared with others in their group, and minimum required sample size were calculated using Cronbach's alpha, factor analysis, and Bayesian probability. Ethnic and professional differences within and across...
Miller, Rupert G
2011-01-01
A concise summary of the statistical methods used in the analysis of survival data with censoring. Emphasizes recently developed nonparametric techniques. Outlines methods in detail and illustrates them with actual data. Discusses the theory behind each method. Includes numerous worked problems and numerical exercises.
Freund, Rudolf J; Sa, Ping
2006-01-01
The book provides complete coverage of the classical methods of statistical analysis. It is designed to give students an understanding of the purpose of statistical analyses, to allow the student to determine, at least to some degree, the correct type of statistical analyses to be performed in a given situation, and have some appreciation of what constitutes good experimental design
Colver, David
2010-01-01
Inclusion analysis is the name given by Operis to a black box testing technique that it has found to make the checking of key financial ratios calculated by spreadsheet models quicker, easier and more likely to find omission errors than code inspection.
The goal of exploration is to find reserves that will earn an adequate rate of return on the capital invested. Neither exploration nor economics is an exact science. The authors must therefore explore in those trends (plays) that have the highest probability of achieving this goal. Trend analysis is a technique for organizing the available data to make these strategic exploration decisions objectively and is in conformance with their goals and risk attitudes. Trend analysis differs from resource estimation in its purpose. It seeks to determine the probability of economic success for an exploration program, not the ultimate results of the total industry effort. Thus the recent past is assumed to be the best estimate of the exploration probabilities for the near future. This information is combined with economic forecasts. The computer software tools necessary for trend analysis are (1) Information data base - requirements and sources. (2) Data conditioning program - assignment to trends, correction of errors, and conversion into usable form. (3) Statistical processing program - calculation of probability of success and discovery size probability distribution. (4) Analytical processing - Monte Carlo simulation to develop the probability distribution of the economic return/investment ratio for a trend. Limited capital (short-run) effects are analyzed using the Gambler's Ruin concept in the Monte Carlo simulation and by a short-cut method. Multiple trend analysis is concerned with comparing and ranking trends, allocating funds among acceptable trends, and characterizing program risk by using risk profiles. In summary, trend analysis is a reality check for long-range exploration planning
Factor Analysis via Components Analysis
Bentler, Peter M.; Jan de Leeuw
2011-01-01
Under the null hypothesis, component loadings are linear combinations of factor loadings, and vice versa. This interrelation permits defining new optimization criteria and estimation methods for exploratory factor analysis. Although this note is primarily conceptual in nature, an illustrative example shows the methodology to be promising.
Cheng, Lizhi; Luo, Yong; Chen, Bo
2014-01-01
This book could be divided into two parts i.e. fundamental wavelet transform theory and method and some important applications of wavelet transform. In the first part, as preliminary knowledge, the Fourier analysis, inner product space, the characteristics of Haar functions, and concepts of multi-resolution analysis, are introduced followed by a description on how to construct wavelet functions both multi-band and multi wavelets, and finally introduces the design of integer wavelets via lifting schemes and its application to integer transform algorithm. In the second part, many applications are discussed in the field of image and signal processing by introducing other wavelet variants such as complex wavelets, ridgelets, and curvelets. Important application examples include image compression, image denoising/restoration, image enhancement, digital watermarking, numerical solution of partial differential equations, and solving ill-conditioned Toeplitz system. The book is intended for senior undergraduate stude...
Freitag, Eberhard
2005-01-01
The guiding principle of this presentation of ``Classical Complex Analysis'' is to proceed as quickly as possible to the central results while using a small number of notions and concepts from other fields. Thus the prerequisites for understanding this book are minimal; only elementary facts of calculus and algebra are required. The first four chapters cover the essential core of complex analysis: - differentiation in C (including elementary facts about conformal mappings) - integration in C (including complex line integrals, Cauchy's Integral Theorem, and the Integral Formulas) - sequences and series of analytic functions, (isolated) singularities, Laurent series, calculus of residues - construction of analytic functions: the gamma function, Weierstrass' Factorization Theorem, Mittag-Leffler Partial Fraction Decomposition, and -as a particular highlight- the Riemann Mapping Theorem, which characterizes the simply connected domains in C. Further topics included are: - the theory of elliptic functions based on...
Andersen, Lars
This book contains the lecture notes for the 9th semester course on elastodynamics. The first chapter gives an overview of the basic theory of stress waves propagating in viscoelastic media. In particular, the effect of surfaces and interfaces in a viscoelastic material is studied, and different ....... Thus, in Chapter 3, an alternative semi-analytic method is derived, which may be applied for the analysis of layered half-spaces subject to moving or stationary loads....
General remarks on sensitivity analysis, the study of changes in a model output produced by varying model inputs, are made first. Sampling methods are discussed, and three sensitivity measures: partial rank correlation, derivative or response surface, and partial variance are described. Some sample results for a 16-input, 13-output hydrodynamics model are given. Both agreement and disagreement were found among the sensitivity measures. 4 figures
Cecconi, Jaures
2011-01-01
G. Bottaro: Quelques resultats d'analyse spectrale pour des operateurs differentiels a coefficients constants sur des domaines non bornes.- L. Garding: Eigenfuction expansions.- C. Goulaouic: Valeurs propres de problemes aux limites irreguliers: applications.- G. Grubb: Essential spectra of elliptic systems on compact manifolds.- J.Cl. Guillot: Quelques resultats recents en Scattering.- N. Schechter: Theory of perturbations of partial differential operators.- C.H. Wilcox: Spectral analysis of the Laplacian with a discontinuous coefficient.
None
1980-06-01
The Energy Policy and Conservation Act (EPCA) mandated that minimum energy efficiency standards be established for classes of refrigerators and refrigerator-freezers, freezers, clothes dryers, water heaters, room air conditioners, home heating equipment, kitchen ranges and ovens, central air conditioners, and furnaces. EPCA requires that standards be designed to achieve the maximum improvement in energy efficiency that is technologically feasible and economically justified. Following the introductory chapter, Chapter Two describes the methodology used in the economic analysis and its relationship to legislative criteria for consumer product efficiency assessment; details how the CPES Value Model systematically compared and evaluated the economic impacts of regulation on the consumer, manufacturer and Nation. Chapter Three briefly displays the results of the analysis and lists the proposed performance standards by product class. Chapter Four describes the reasons for developing a baseline forecast, characterizes the baseline scenario from which regulatory impacts were calculated and summarizes the primary models, data sources and assumptions used in the baseline formulations. Chapter Five summarizes the methodology used to calculate regulatory impacts; describes the impacts of energy performance standards relative to the baseline discussed in Chapter Four. Also discussed are regional standards and other program alternatives to performance standards. Chapter Six describes the procedure for balancing consumer, manufacturer, and national impacts to select standard levels. Details of models and data bases used in the analysis are included in Appendices A through K.
This is the twenty-first biennial review of the inorganic and organic analytical chemistry of water. The format of this review differs somewhat from previous reviews in this series - the most recent of which appeared in Analytical Chemistry in April 1983. Changes in format have occurred in the presentation of material concerning review articles and the inorganic analysis of water sections. Organic analysis of water sections are organized as in previous reviews. Review articles have been compiled and tabulated in an Appendix with respect to subject, title, author(s), citation, and number of references cited. The inorganic water analysis sections are now grouped by constituent using the periodic chart; for example, alkali, alkaline earth, 1st series transition metals, etc. Within these groupings the references are roughly grouped by instrumental technique; for example, spectrophotometry, atomic absorption spectrometry, etc. Multiconstituent methods for determining analytes that cannot be grouped in this manner are compiled into a separate section sorted by instrumental technique. References used in preparing this review were compiled from nearly 60 major journals published during the period from October 1982 through September 1984. Conference proceedings, most foreign journals, most trade journals, and most government publications are excluded. References cited were obtained using the American Chemical Society's Chemical Abstracts for sections on inorganic analytical chemistry, organic analytical chemistry, water, and sewage waste. Cross-references of these sections were also included. 860 references
Newell, Homer E
2006-01-01
When employed with skill and understanding, vector analysis can be a practical and powerful tool. This text develops the algebra and calculus of vectors in a manner useful to physicists and engineers. Numerous exercises (with answers) not only provide practice in manipulation but also help establish students' physical and geometric intuition in regard to vectors and vector concepts.Part I, the basic portion of the text, consists of a thorough treatment of vector algebra and the vector calculus. Part II presents the illustrative matter, demonstrating applications to kinematics, mechanics, and e
Wald, Abraham
2013-01-01
In 1943, while in charge of Columbia University's Statistical Research Group, Abraham Wald devised Sequential Design, an innovative statistical inference system. Because the decision to terminate an experiment is not predetermined, sequential analysis can arrive at a decision much sooner and with substantially fewer observations than equally reliable test procedures based on a predetermined number of observations. The system's immense value was immediately recognized, and its use was restricted to wartime research and procedures. In 1945, it was released to the public and has since revolutio
Clement, J. D.; Kirby, K. D.
1973-01-01
Exploratory calculations were performed for several gas core breeder reactor configurations. The computational method involved the use of the MACH-1 one dimensional diffusion theory code and the THERMOS integral transport theory code for thermal cross sections. Computations were performed to analyze thermal breeder concepts and nonbreeder concepts. Analysis of breeders was restricted to the (U-233)-Th breeding cycle, and computations were performed to examine a range of parameters. These parameters include U-233 to hydrogen atom ratio in the gaseous cavity, carbon to thorium atom ratio in the breeding blanket, cavity size, and blanket size.
Brand, Louis
2006-01-01
The use of vectors not only simplifies treatments of differential geometry, mechanics, hydrodynamics, and electrodynamics, but also makes mathematical and physical concepts more tangible and easy to grasp. This text for undergraduates was designed as a short introductory course to give students the tools of vector algebra and calculus, as well as a brief glimpse into these subjects' manifold applications. The applications are developed to the extent that the uses of the potential function, both scalar and vector, are fully illustrated. Moreover, the basic postulates of vector analysis are brou
Popovová, Šárka
2015-01-01
The aim of this bachelor thesis is to define basic methods, which are used for the preparation of a business strategy and to use those methods in a real situation. The theoretical part describes the methodology of external and internal analysis. The practical part then applies single methods such as PEST, VRIO, Porter`s five forces and value chain in order to define competitive advantages of Dr. Popov company. At the end of the Bachelor thesis will be assessment of the current situation and s...
Abbott, Stephen
2015-01-01
This lively introductory text exposes the student to the rewards of a rigorous study of functions of a real variable. In each chapter, informal discussions of questions that give analysis its inherent fascination are followed by precise, but not overly formal, developments of the techniques needed to make sense of them. By focusing on the unifying themes of approximation and the resolution of paradoxes that arise in the transition from the finite to the infinite, the text turns what could be a daunting cascade of definitions and theorems into a coherent and engaging progression of ideas. Acutely aware of the need for rigor, the student is much better prepared to understand what constitutes a proper mathematical proof and how to write one. Fifteen years of classroom experience with the first edition of Understanding Analysis have solidified and refined the central narrative of the second edition. Roughly 150 new exercises join a selection of the best exercises from the first edition, and three more project-sty...
After ten years of operation at the Atucha I Nuclear Power Station a gear belonging to a pressurized heavy water reactor refuelling machine, failed. The gear box was used to operate the inlet-outlet heavy-water valve of the machine. Visual examination of the gear device showed an absence of lubricant and that several gear teeth were broken at the root. Motion was transmitted with a speed-reducing device with controlled adjustable times in order to produce a proper fitness of the valve closure. The aim of this paper is to discuss the results of the gear failure analysis in order to recommend the proper solution to prevent further failures. (Author)
Pharyngeal analysis studies examine the function of the oropharyngeal structures and confirms or refutes the impression formed during the bedside clinical assessment. Three test meals consisting of liquid barium, puree, and cookie crumbs are usually used. These consistencies do not help either the nurses or the relatives of the patients in choosing meals. The authors use several test meals that equate to real-life foods. The equivalent real-life foods can be produced in any kitchen. The examination is done with a radiologist, speech pathologist, and a nutritionist present, and a single multidisciplinary report is issued after review of the video study. This report indicates which foods the patient can swallow effectively without aspiration and is much more useful than the three test meals for ongoing management
Rockafellar, R Tyrrell
1998-01-01
From its origins in the minimization of integral functionals, the notion of 'variations' has evolved greatly in connection with applications in optimization, equilibrium, and control. It refers not only to constrained movement away from a point, but also to modes of perturbation and approximation that are best describable by 'set convergence', variational convergence of functions and the like. This book develops a unified framework and, in finite dimension, provides a detailed exposition of variational geometry and subdifferential calculus in their current forms beyond classical and convex analysis. Also covered are set-convergence, set-valued mappings, epi-convergence, duality, maximal monotone mappings, second-order subderivatives, measurable selections and normal integrands. The changes in this 3rd printing mainly concern various typographical corrections, and reference omissions that came to light in the previous printings. Many of these reached the authors' notice through their own re-reading, that of th...
Bone metastasis: review and critical analysis of random allocation trials of local field treatment
Purpose: Compare and contrast reports of random allocation clinical trials of local field radiation therapy of metastases to bone to determine the techniques producing the best results (frequency, magnitude, and duration of benefit), and relate these to the goals of complete relief of pain and prevention of disability for the remaining life of the patient. Methods and Materials: Review all published reports of random allocation clinical trials, and perform a systematic analysis of the processes and outcomes of the several trial reports. Results: All trials were performed on selected populations of patients with symptomatic metastases and most studies included widely diverse groups with regard to: (a) site of primary tumor, (b) location, extent, size, and nature of metastases, (c) duration of survival after treatment. All trial reports lack sufficient detail for full and complete analysis. Much collected information is not now available for reanalysis and many important data sets were apparently never collected. Several of the variations in patient and tumor characteristics were found to be much more important than treatment dose in the outcome results. Treatment planning and delivery techniques were unsophisticated and probably resulted in a systematic delivery of less than the assigned dose to some metastases. In general the use and benefit of retreatment was greater in those patients who initially received lower doses but the basis and dose of retreatment was not documented. Follow-up of patients was varied with a large proportion of surviving patients lost to follow-up in several studies. The greatest difference in the reports is the method of calculation of results. The applicability of Kaplan-Meier actuarial analysis, censoring the lost and dead patients, as used in studies with loss to follow-up of a large number of patients is questionable. The censoring involved is 'informative' (the processes of loss relate to the outcome) and not acceptable since it
Thomas, R.E.
1982-03-01
An evaluation is made of the suitability of analytical and statistical sampling methods for making uncertainty analyses. The adjoint method is found to be well-suited for obtaining sensitivity coefficients for computer programs involving large numbers of equations and input parameters. For this purpose the Latin Hypercube Sampling method is found to be inferior to conventional experimental designs. The Latin hypercube method can be used to estimate output probability density functions, but requires supplementary rank transformations followed by stepwise regression to obtain uncertainty information on individual input parameters. A simple Cork and Bottle problem is used to illustrate the efficiency of the adjoint method relative to certain statistical sampling methods. For linear models of the form Ax=b it is shown that a complete adjoint sensitivity analysis can be made without formulating and solving the adjoint problem. This can be done either by using a special type of statistical sampling or by reformulating the primal problem and using suitable linear programming software.
Bhatia, Rajendra
1997-01-01
A good part of matrix theory is functional analytic in spirit. This statement can be turned around. There are many problems in operator theory, where most of the complexities and subtleties are present in the finite-dimensional case. My purpose in writing this book is to present a systematic treatment of methods that are useful in the study of such problems. This book is intended for use as a text for upper division and gradu ate courses. Courses based on parts of the material have been given by me at the Indian Statistical Institute and at the University of Toronto (in collaboration with Chandler Davis). The book should also be useful as a reference for research workers in linear algebra, operator theory, mathe matical physics and numerical analysis. A possible subtitle of this book could be Matrix Inequalities. A reader who works through the book should expect to become proficient in the art of deriving such inequalities. Other authors have compared this art to that of cutting diamonds. One first has to...
This review is the seventh in the series compiled by using the Dialog on-line CA Search facilities at the Information Resource Center of USS Technical Center covering the period from Oct. 1984 to Nov. 1, 1986. The quest for better surface properties, through the application of various electrochemical and other coating techniques, seems to have increased and reinforces the notion that only through the value added to a steel by proper finishing steps can a major supplier hope to compete profitably. The detection, determination, and control of microalloying constituents has also been generating a lot of interest as evidenced by the number of publications devoted to this subject in the last few years. Several recent review articles amplify on the recent trends in the application of modern analytical technology to steelmaking. Another review has been devoted to the determination of trace elements and the simultaneous determination of elements in metals by mass spectrometry, atomic absorption spectrometry, and multielement emission spectrometry. Problems associated with the analysis of electroplating wastewaters have been reviewed in a recent publication that has described the use of various spectrophotometric methods for this purpose. The collection and treatment of analytical data in the modern steel making environment have been extensively reviewed emphasis on the interaction of the providers and users of the analytical data, its quality, and the cost of its collection. Raw material treatment and beneficiation was the dominant theme
... Home Visit Global Sites Search Help? Pericardial Fluid Analysis Share this page: Was this page helpful? Formal name: Pericardial Fluid Analysis Related tests: Pleural Fluid Analysis , Peritoneal Fluid Analysis , ...
... Home Visit Global Sites Search Help? Peritoneal Fluid Analysis Share this page: Was this page helpful? Formal name: Peritoneal Fluid Analysis Related tests: Pleural Fluid Analysis , Pericardial Fluid Analysis , ...
Information security risk analysis
Peltier, Thomas R
2001-01-01
Effective Risk AnalysisQualitative Risk AnalysisValue AnalysisOther Qualitative MethodsFacilitated Risk Analysis Process (FRAP)Other Uses of Qualitative Risk AnalysisCase StudyAppendix A: QuestionnaireAppendix B: Facilitated Risk Analysis Process FormsAppendix C: Business Impact Analysis FormsAppendix D: Sample of ReportAppendix E: Threat DefinitionsAppendix F: Other Risk Analysis OpinionsIndex
This book deals with information technology and business process, information system architecture, methods of system development, plan on system development like problem analysis and feasibility analysis, cases for system development, comprehension of analysis of users demands, analysis of users demands using traditional analysis, users demands analysis using integrated information system architecture, system design using integrated information system architecture, system implementation, and system maintenance.
Theoretical numerical analysis a functional analysis framework
Atkinson, Kendall
2005-01-01
This textbook prepares graduate students for research in numerical analysis/computational mathematics by giving to them a mathematical framework embedded in functional analysis and focused on numerical analysis. This helps the student to move rapidly into a research program. The text covers basic results of functional analysis, approximation theory, Fourier analysis and wavelets, iteration methods for nonlinear equations, finite difference methods, Sobolev spaces and weak formulations of boundary value problems, finite element methods, elliptic variational inequalities and their numerical solu
Amanda B. Powers-Sawyer
2009-12-01
Full Text Available Sexual offending among youth retains a great deal of attention from public policy decision-makers in the juvenile justice system despite the low rate at which juveniles sexually reoffend. Within the judicial system, evaluators are faced with the challenge of answering questions from the court regarding sexual recidivism potential and corresponding treatment placements. Empirical investigations link empirically supported and promising risk factors to sexual reoffending among juveniles across several studies. However, there is little cumulative evidence for strong predictive strength among risk assessment tools for juvenile sexual recidivism. We found the static variables of the Juvenile Sex Offender Assessment Protocol-II to have strong predictive accuracy for sexual recidivism (AUC=.75 among 7 sexual recidivists in a sample of 96 juvenile sex offenders. The J-SOAP-II was a poor predictor for non-sexual violent recidivism and non-sexual general recidivism. Additionally, we found that the predictive accuracy of the J-SOAP-II is stronger for the sex drive/preoccupation scale (AUC=.72 than the impulsive/anti-social behavior scale (AUC=.64. These data provide preliminary evidence for the predictive validity of the J-SOAP-II and indicate much of the predictive power is due to the measure of sexual drive rather than impulsivity.
The Actuarial Model of Pension Fund balance%养老保险基金收支平衡精算模型
汤志浩
2015-01-01
In 2000, China entered the aging society ranks, then our society aging trend is increasingly serious, "Old before get-ting rich" national condition and aging population to China’s old-age insurance system brought huge impact, the reform of pension insurance system, we must first ensure that the endowment insurance fund balance, otherwise the endowment insurance system fi-nally only tends to collapse. So the study on the pension payments under the background of population aging and its relevant fac-tors, has important significance.%2000年中国步入了老年社会的行列，此后我国社会的老龄化趋势日益严重，“未富先老”的国情以及人口老龄化加剧给中国现今的养老保险制度带来了巨大冲击。改革养老保险制度，首先要保证养老保险基金的收支平衡，否则养老保险体系最终只能趋于覆灭。因此研究老龄化背景下养老金收支情况及其相关因素，具有重要意义。
Robert Meneu Gaya
2013-05-01
Full Text Available La Ley 27/2011, que reforma el sistema de pensiones español, introduce el factor de sostenibilidad, un instrumento que ajusta automáticamente los parámetros del sistema a la evolución de la esperanza de vida a partir del año 2027 y con revisiones cada 5 años, aunque la reciente Ley Orgánica 2/2012 de Estabilidad Presupuestaria y Sostenibilidad Financiera abre la posibilidad de que se anticipe su entrada en vigor si se proyecta un déficit a largo plazo en el sistema de pensiones. Dado que el diseño concreto del factor de sostenibilidad está pendiente, resulta relevante analizar cómo otros países de la Unión Europea han incorporado instrumentos similares en sus sistemas de pensiones y, desde esas experiencias, ofrecer diseños alternativos para el caso español, valorando los efectos de cada uno de ellos sobre los parámetros del sistema, utilizando para ello las recientes proyecciones de esperanza de vida del Instituto Nacional de Estadística. La Ley 27/2011, que reforma el sistema de pensiones español, introduce el factor de sostenibilidad, un instrumento que ajusta automáticamente los parámetros del sistema a la evolución de la esperanza de vida a partir del año 2027 y con revisiones cada 5 años, aunque la reciente Ley Orgánica 2/2012 de Estabilidad Presupuestaria y Sostenibilidad Financiera abre la posibilidad de que se anticipe su entrada en vigor si se proyecta un déficit a largo plazo en el sistema de pensiones. Dado que el diseño concreto del factor de sostenibilidad está pendiente, resulta relevante analizar cómo otros países de la Unión Europea han incorporado instrumentos similares en sus sistemas de pensiones y, desde esas experiencias, ofrecer diseños alternativos para el caso español, valorando los efectos de cada uno de ellos sobre los parámetros del sistema, utilizando para ello las recientes proyecciones de esperanza de vida del Instituto Nacional de Estadística.
Mª Manuela Segovia; Flor Mª Guerrero; Patricia Herranz
2005-01-01
En los países industrializados, convergen dos fenómenos demográficos, la longevidad y la escasa natalidad, que provocan un envejecimiento de la población y con ello una serie de procesos sociales que son necesarios atender. Uno de ellos, es la cobertura de la dependencia de las personas mayores, entendiendo por dependencia, la necesidad de ayuda para realizar las tareas básicas de la vida diaria. España se encuentra en la actualidad en plena discusión parlamentaria para regular mediante ...
Purpose: To assess prognostic factors for bladder relapse and distant failure following definitive radiotherapy for invasive transitional cell carcinoma (TCC) of the bladder. Methods and Materials: Retrospective review of patients treated in the period 1977 to 1990 by definitive radiotherapy. The factors studied included age, sex, T stage, histological grade, tumor multiplicity, ureteric obstruction, total radiation dose, and use of neoadjuvant chemotherapy. The endpoints studied were bladder relapse and distant failure. Results: There were 342 patients with a mean follow-up time of 7.9 years. Bladder relapse was observed in 159 patients. The overall actuarial bladder relapse rate at 5 years was 55% (SE = 3%). Prognostic factors for a higher bladder relapse rate were: tumor multiplicity (p < 0.001), presence of ureteric obstruction (p = 0.001), and higher T stage (p 0.044). Distant failure occurred in 39 patients. The overall actuarial distant failure rate at 5 years was 28% (SE = 3%). Prognostic factors for a higher distant failure rate were: ureteric obstruction (p = 0.003) and higher T stage (p = 0.030). Conclusion: In our study, patients with invasive bladder TCC fell into distinct prognostic groups determined by the three independent factors, ureteric obstruction, tumor multiplicity, and T stage. These factors provided estimated risks of bladder relapse by 5 years which ranged from 34% to 91%. Knowledge of these prognostic factors can help in the selection of patients more suited for bladder preservation by definitive radiotherapy
An example of multidimensional analysis: Discriminant analysis
Among the approaches on the data multi-dimensional analysis, lectures on the discriminant analysis including theoretical and practical aspects are presented. The discrimination problem, the analysis steps and the discrimination categories are stressed. Examples on the descriptive historical analysis, the discrimination for decision making, the demonstration and separation of the top quark are given. In the linear discriminant analysis the following subjects are discussed: Huyghens theorem, projection, discriminant variable, geometrical interpretation, case for g=2, classification method, separation of the top events. Criteria allowing the obtention of relevant results are included
Basic principles of neutron activation analysis are outlined. Examples of its use in police science include analysis for gunshot residues, toxic element determinations and multielement comparisons. Advantages of neutron activation analysis over other techniques are described. (R.L.)
Papageorgiou, Nikolaos S
2009-01-01
Offers an examination of important theoretical methods and procedures in applied analysis. This book details the important theoretical trends in nonlinear analysis and applications to different fields. It is suitable for those working on nonlinear analysis.
Wilkinson, J. Ben [Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Beitsch, Peter D. [Dallas Surgical Group, Dallas, Texas (United States); Shah, Chirag [Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri (United States); Arthur, Doug [Department of Radiation Oncology, Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia (United States); Haffty, Bruce G. [Department of Radiation Oncology, Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Camden, New Jersey (United States); Wazer, David E. [Department of Radiation Oncology, Tufts Medical Center, Boston, Massachusetts and Rhode Island Hospital/Brown University, Providence, Rhode Island (United States); Keisch, Martin [Department of Radiation Oncology, Cancer Healthcare Associates, Miami, Florida (United States); Shaitelman, Simona F. [Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas (United States); Lyden, Maureen [Biostat International, Inc, Tampa, Florida (United States); Chen, Peter Y. [Department of Radiation Oncology, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (United States); Vicini, Frank A., E-mail: fvicini@pol.net [Department of Radiation Oncology, Michigan Healthcare Professionals/21st Century Oncology, Farmington Hills, Michigan (United States)
2013-04-01
Purpose: To determine whether the American Society for Radiation Oncology (ASTRO) Consensus Statement (CS) recommendations for accelerated partial breast irradiation (APBI) are associated with significantly different outcomes in a pooled analysis from William Beaumont Hospital (WBH) and the American Society of Breast Surgeons (ASBrS) MammoSite® Registry Trial. Methods and Materials: APBI was used to treat 2127 cases of early-stage breast cancer (WBH, n=678; ASBrS, n=1449). Three forms of APBI were used at WBH (interstitial, n=221; balloon-based, n=255; or 3-dimensional conformal radiation therapy, n=206), whereas all Registry Trial patients received balloon-based brachytherapy. Patients were divided according to the ASTRO CS into suitable (n=661, 36.5%), cautionary (n=850, 46.9%), and unsuitable (n=302, 16.7%) categories. Tumor characteristics and clinical outcomes were analyzed according to CS group. Results: The median age was 65 years (range, 32-94 years), and the median tumor size was 10.0 mm (range, 0-45 mm). The median follow-up time was 60.6 months. The WBH cohort had more node-positive disease (6.9% vs 2.6%, P<.01) and cautionary patients (49.5% vs 41.8%, P=.06). The 5-year actuarial ipsilateral breast tumor recurrence (IBTR), regional nodal failure (RNF), and distant metastasis (DM) for the whole cohort were 2.8%, 0.6%, 1.6%. The rate of IBTR was not statistically higher between suitable (2.5%), cautionary (3.3%), or unsuitable (4.6%) patients (P=.20). The nonsignificant increase in IBTR for the cautionary and unsuitable categories was due to increased elsewhere failures and new primaries (P=.04), not tumor bed recurrence (P=.93). Conclusions: Excellent outcomes after breast-conserving surgery and APBI were seen in our pooled analysis. The current ASTRO CS guidelines did not adequately differentiate patients at an increased risk of IBTR or tumor bed failure in this large patient cohort.
Purpose: To determine whether the American Society for Radiation Oncology (ASTRO) Consensus Statement (CS) recommendations for accelerated partial breast irradiation (APBI) are associated with significantly different outcomes in a pooled analysis from William Beaumont Hospital (WBH) and the American Society of Breast Surgeons (ASBrS) MammoSite® Registry Trial. Methods and Materials: APBI was used to treat 2127 cases of early-stage breast cancer (WBH, n=678; ASBrS, n=1449). Three forms of APBI were used at WBH (interstitial, n=221; balloon-based, n=255; or 3-dimensional conformal radiation therapy, n=206), whereas all Registry Trial patients received balloon-based brachytherapy. Patients were divided according to the ASTRO CS into suitable (n=661, 36.5%), cautionary (n=850, 46.9%), and unsuitable (n=302, 16.7%) categories. Tumor characteristics and clinical outcomes were analyzed according to CS group. Results: The median age was 65 years (range, 32-94 years), and the median tumor size was 10.0 mm (range, 0-45 mm). The median follow-up time was 60.6 months. The WBH cohort had more node-positive disease (6.9% vs 2.6%, P<.01) and cautionary patients (49.5% vs 41.8%, P=.06). The 5-year actuarial ipsilateral breast tumor recurrence (IBTR), regional nodal failure (RNF), and distant metastasis (DM) for the whole cohort were 2.8%, 0.6%, 1.6%. The rate of IBTR was not statistically higher between suitable (2.5%), cautionary (3.3%), or unsuitable (4.6%) patients (P=.20). The nonsignificant increase in IBTR for the cautionary and unsuitable categories was due to increased elsewhere failures and new primaries (P=.04), not tumor bed recurrence (P=.93). Conclusions: Excellent outcomes after breast-conserving surgery and APBI were seen in our pooled analysis. The current ASTRO CS guidelines did not adequately differentiate patients at an increased risk of IBTR or tumor bed failure in this large patient cohort
Purpose: We reviewed our institution's experience in treating patients with clinically localized prostate cancer with external beam irradiation (RT) to determine if previously analyzed clinical and treatment related prognostic factors affected outcome when biochemical control was used as an end-point to evaluate results. Materials and methods: Between 1 January 1987 and 31 December 1991, 470 patients with clinically localized prostate cancer were treated with external beam RT using localized prostate fields at William Beaumont Hospital. Biochemical control was defined as PSA nadir ≤1.5 ng/ml within 1 year of treatment. After achieving nadir, if two consecutive increases of PSA were noted, the patient was scored a failure at the time of the first increase. Prognostic factors, including the total number of days in treatment, the method of diagnosis, a history of any pretreatment transurethral resection of the prostate (TURP) and the type of boost were analyzed. Results: Median follow-up was 48 months. No statistically significant difference in rates of biochemical control were noted for treatment time, overall time (date of biopsy to completion of RT), history of any pretreatment TURP, history of diagnosis by TURP, or boost techniques. Patients diagnosed by TURP had a significant improvement in the overall rate of biochemical control (P < 0.03) compared to transrectal/transperineal biopsy. The 5-year actuarial rates were 58 versus 39%, respectively. This improvement was not evident when pretreatment PSA, T stage, or Gleason score were controlled for. On multivariate analysis, no variable was associated with outcome. When analysis was limited to a more favorable group of patients (T1/T2 tumors, pretreatment PSA ≤20 ng/ml and Gleason score <7), none of these variables were significantly predictive of biochemical control when controlling for pretreatment PSA, T stage and Gleason score. Conclusions: No significant effect of treatment time, overall time, pretreatment
Purpose: To analyze factors influencing outcome in patients who received postoperative irradiation for advanced squamous cell carcinoma of the oral cavity. Methods and Materials: Between October 1964 and November 1993, 134 patients with 135 previously untreated primary invasive squamous cell carcinomas of the oral cavity (excluding the lip) were treated postoperatively with continuous courses of external-beam irradiation at the University of Florida. All patients had a minimum follow-up of 2 years (analysis, December 1995). No patient was lost to follow-up. Results: The 10-year actuarial rates of primary site, neck, and local-regional control were 79%, 88%, and 71%, respectively. Recurrence of cancer above the clavicles developed in 35 patients. Ninety-four percent of the recurrences were within the primary field of irradiation (anterior to the plane of the spinal cord); there were 24 recurrences at the primary site and nine in the upper neck alone. There were no failures in the neck area behind the plane of the spinal cord (i.e., the 'posterior strip'). Two failures occurred in the low neck below the level of the thyroid notch. In univariate analyses, factors that affected local-regional control included pathologic stage (I-II vs. III-IV, p = 0.04), margin status (invasive cancer at the margin vs. other, p = 0.0007), multifocal tumor (p = 0.05), peri neural invasion (p 0.04), and number of indications for postoperative irradiation (p = 0.05). Extracapsular nodal extension was marginally significant (p = 0.07). In multivariate analysis, positive margins and number of indications remained significant. These factors were used to define relatively favorable (< 4 indications, margins not positive) and unfavorable (≥ 4 indications and/or margins positive for invasive cancer) groups. For both favorable and unfavorable groups, there were nonsignificant trends toward improved local-regional control for patients who began irradiation within 45-50 days, compared with those
Badakhshi, Harun; Graf, Reinhold; Budach, Volker; Wust, Peter [University Hospital Berlin, Department for Radiation Oncology of Charite School of Medicine, Berlin (Germany)
2015-04-01
The biochemical relapse-free survival (bRFS) rate after treatment with permanent iodine-125 seed implantation (PSI) or combined seeds and external beam radiotherapy (COMB) for clinical stage T1-T2 localized prostate cancer is a clinically relevant endpoint. The goal of this work was to evaluate the influence of relevant patient- and treatment-related factors. The study population comprised 312 consecutive patients treated with permanent seed implantation. All patients were evaluable for analysis of overall survival (OS) and disease-specific survival (DSS), 230 for bRFS, of which 192 were in the PSI group and 38 in the COMB group. The prescribed minimum peripheral dose was 145 Gy for PSI, for COMB 110 Gy implant and external beam radiotherapy of 45 Gy. The median follow-up time was 33 months (range 8-66 months). bRFS was defined as a serum prostate-specific antigen (PSA) level ≤ 0.2 ng/ml at last follow-up. Overall, the actuarial bRFS at 50 months was 88.4 %. The 50-month bRFS rate for PSI and COMB was 90.9 %, and 77.2 %, respectively. In the univariate analysis, age in the categories ≤ 63 and > 63 years (p < 0.00), PSA nadir (≤ 0.5 ng/ml and > 0.5 ng/ml) and PSA bounce (yes/no) were the significant predicting factors for bRFS. None of the other patient and treatment variables (treatment modality, stage, PSA, Gleason score, risk group, number of risk factors, D90 and various other dose parameters) were found to be a statistically significant predictor of 50-month bRFS. The biochemical failure rates were low in this study. As a proof of principle, our large monocenteric analysis shows that low-dose-rate brachytherapy is an effective and safe procedure for patients with early stage prostate cancer. (orig.) [German] Das biochemisch rezidivfreie Ueberleben (bRFS) nach der Brachytherapie mit permanenter Iod-125-Seed-Implantation (PSI) oder in Kombination mit externer Radiotherapie (COMB) ist beim Patienten mit fruehem Prostatakarzinom (T1/T2) ein relevanter
NHT on FPF. Results: As has been previously demonstrated by others, the P-PSA was the single most important prognostic factor. The actuarial incidence of freedom from FPF at 4 years was 90% for patients with a PSA 6 and a PSA 71.5 Gy compared to 71.5 Gy, the use of NHT was associated with an improvement in the FPF at 4 years (70% vs 50%, p 71.5 Gy. Conclusions: This preliminary analysis suggests that the use of NHT is associated with an improved FPF and some subsets of patients may benefit from being treated to > 71.5 Gy. Longer follow-up will be required to assess the impact of these factors on survival
Shape analysis in medical image analysis
Tavares, João
2014-01-01
This book contains thirteen contributions from invited experts of international recognition addressing important issues in shape analysis in medical image analysis, including techniques for image segmentation, registration, modelling and classification, and applications in biology, as well as in cardiac, brain, spine, chest, lung and clinical practice. This volume treats topics such as, anatomic and functional shape representation and matching; shape-based medical image segmentation; shape registration; statistical shape analysis; shape deformation; shape-based abnormity detection; shape tracking and longitudinal shape analysis; machine learning for shape modeling and analysis; shape-based computer-aided-diagnosis; shape-based medical navigation; benchmark and validation of shape representation, analysis and modeling algorithms. This work will be of interest to researchers, students, and manufacturers in the fields of artificial intelligence, bioengineering, biomechanics, computational mechanics, computationa...
杜梅香
2006-01-01
This paper is about the discourse analysis and illustrate the approach to analysis the Critical discourses and the discourses about the educational situation of China. And it also includes the condensed theoretical support of the Critical discourse analysis and analysis of the sample I of the discourses between an illiterate person and the literate.
Ibsen, Lars Bo; Liingaard, Morten
This technical report concerns the basic theory and principles for experimental modal analysis. The sections within the report are: Output-only modal analysis software (section 1.1), general digital analysis (section 1.2), basics of structural dynamics and modal analysis (section 1.3) and system...
Foundations of factor analysis
Mulaik, Stanley A
2009-01-01
Introduction Factor Analysis and Structural Theories Brief History of Factor Analysis as a Linear Model Example of Factor AnalysisMathematical Foundations for Factor Analysis Introduction Scalar AlgebraVectorsMatrix AlgebraDeterminants Treatment of Variables as Vectors Maxima and Minima of FunctionsComposite Variables and Linear Transformations Introduction Composite Variables Unweighted Composite VariablesDifferentially Weighted Composites Matrix EquationsMulti
Using orCAD Pspice EDA software, the circuit simulation and the analysis such as transient analysis, noise analysis, temperature analysis, are made for charge-sensitive preamplifier. By calculation and comparison, the result shows circuit noise responses according to the temperature changes. (authors)
This report describes the methodology used in conducting the K Basins Hazard Analysis, which provides the foundation for the K Basins Final Safety Analysis Report. This hazard analysis was performed in accordance with guidance provided by DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports and implements the requirements of DOE Order 5480.23, Nuclear Safety Analysis Report
This report describes the methodology used in conducting the K Basins Hazard Analysis, which provides the foundation for the K Basins Safety Analysis Report (HNF-SD-WM-SAR-062/Rev.4). This hazard analysis was performed in accordance with guidance provided by DOE-STD-3009-94, Preparation Guide for U. S. Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports and implements the requirements of DOE Order 5480.23, Nuclear Safety Analysis Report
Quantitative analysis chemistry
This book is about quantitative analysis chemistry. It is divided into ten chapters, which deal with the basic conception of material with the meaning of analysis chemistry and SI units, chemical equilibrium, basic preparation for quantitative analysis, introduction of volumetric analysis, acid-base titration of outline and experiment examples, chelate titration, oxidation-reduction titration with introduction, titration curve, and diazotization titration, precipitation titration, electrometric titration and quantitative analysis.
Analysis of Precision of Activation Analysis Method
Heydorn, Kaj; Nørgaard, K.
1973-01-01
The precision of an activation-analysis method prescribes the estimation of the precision of a single analytical result. The adequacy of these estimates to account for the observed variation between duplicate results from the analysis of different samples and materials, is tested by the statistic T...
Santiago, John
2013-01-01
Circuits overloaded from electric circuit analysis? Many universities require that students pursuing a degree in electrical or computer engineering take an Electric Circuit Analysis course to determine who will ""make the cut"" and continue in the degree program. Circuit Analysis For Dummies will help these students to better understand electric circuit analysis by presenting the information in an effective and straightforward manner. Circuit Analysis For Dummies gives you clear-cut information about the topics covered in an electric circuit analysis courses to help
Cluster analysis for applications
Anderberg, Michael R
1973-01-01
Cluster Analysis for Applications deals with methods and various applications of cluster analysis. Topics covered range from variables and scales to measures of association among variables and among data units. Conceptual problems in cluster analysis are discussed, along with hierarchical and non-hierarchical clustering methods. The necessary elements of data analysis, statistics, cluster analysis, and computer implementation are integrated vertically to cover the complete path from raw data to a finished analysis.Comprised of 10 chapters, this book begins with an introduction to the subject o
Georgiana Cristina NUKINA
2012-07-01
Full Text Available Through Risk analysis developed model deciding whether control measures suitable for implementation. However, the analysis determines whether the benefits of a data control options cost more than the implementation.
Joint fluid analysis; Joint fluid aspiration ... El-Gabalawy HS. Synovial fluid analysis, synovial biopsy, and synovial pathology. In: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, eds. Kelly's Textbook of ...
Hostick, Donna J.; Nicholls, Andrew K.; McDonald, Sean C.; Hollomon, Jonathan B.
2005-08-01
A joint NREL, ORNL, and PNNL team conducted market analysis to help inform DOE/EERE's Weatherization and Intergovernmental Program planning and management decisions. This chapter presents the results of the market analysis for the Buildings sector.
Event history analysis: overview
Keiding, Niels
2001-01-01
Survival analysis, Multi-state models, Counting processes, Aalen-Johansen estimator, Markov processes......Survival analysis, Multi-state models, Counting processes, Aalen-Johansen estimator, Markov processes...
Durbin, Richard; Eddy, Sean; Krogh, Anders Stærmose;
This book provides an up-to-date and tutorial-level overview of sequence analysis methods, with particular emphasis on probabilistic modelling. Discussed methods include pairwise alignment, hidden Markov models, multiple alignment, profile searches, RNA secondary structure analysis, and...
Deckert, George
2010-01-01
This viewgraph presentation reviews The NASA Hazard Analysis process. The contents include: 1) Significant Incidents and Close Calls in Human Spaceflight; 2) Subsystem Safety Engineering Through the Project Life Cycle; 3) The Risk Informed Design Process; 4) Types of NASA Hazard Analysis; 5) Preliminary Hazard Analysis (PHA); 6) Hazard Analysis Process; 7) Identify Hazardous Conditions; 8) Consider All Interfaces; 9) Work a Preliminary Hazard List; 10) NASA Generic Hazards List; and 11) Final Thoughts
Whitaker, Simon
2009-01-01
It is argued that the determinates of low frequency (less than once an hour) challenging behavior are likely to be more complex than those of high frequency behavior involving setting events that may not be present when the behavior occurs. The analysis of case records is then examined as a method of identifying possible setting events to low frequency behaviours. It is suggested that time series analysis, correlational analysis and time lag sequential analysis may all be useful methods in th...
Analysis of Business Environment
Horáková, Eva
2012-01-01
This bachelor's theses deals with analysis of the entrepreneurial environment of the company ALBO okna - dveře, s.r.o. . With the help of SWOT analysis, passportisation and Porter's analysis of five rival companies an analysis of the entrepreneurial environment, in which the company ALBO okna - dveře, s.r.o. is situated, will be carried out. This theses also comprises the evaluation of opportunities and risks resulting from the given entrepreneurial environment.
Computer Programming Job Analysis
Debdulal Dutta Roy
2002-01-01
This study investigated relative uses of computer programming job characteristics across different organizations and effects of different demographic variables on job analysis ratings. Data were collected from 201 computer programers of 6 different organizations through checklist. Principal component analysis noted four mostly used job characteristics as program writing and testing, human relations, data analysis and user satisfaction. Of them only data analysis differed among different organ...
Discourse analysis and Foucault's
Jansen I.
2008-01-01
Full Text Available Discourse analysis is a method with up to now was less recognized in nursing science, althoughmore recently nursing scientists are discovering it for their purposes. However, several authors have criticized thatdiscourse analysis is often misinterpreted because of a lack of understanding of its theoretical backgrounds. In thisarticle, I reconstruct Foucault’s writings in his “Archaeology of Knowledge” to provide a theoretical base for futurearchaeological discourse analysis, which can be categorized as a socio-linguistic discourse analysis.
Extending Scalasca's analysis features
Lorenz, Daniel; Böhme, David; Mohr, Bernd; Strube, Alexandre; Szebenyi, Zoltan
2013-01-01
Scalasca is a performance analysis tool, which parses the trace of an application run for certain patterns that indicate performance inefficiencies. In this paper, we present recently developed new features in Scalasaca. In particular, we describe two newly implemented analysis methods: the root cause analysis which tries to identify the cause of a delay and the critical path analysis, which analyses the path of execution that determines the application runtime. Furthermore, we present time-s...
SOFAS: Software Analysis Services
Ghezzi, G
2010-01-01
We propose a distributed and collaborative software analysis platform to enable seamless interoperability of software analysis tools across platform, geographical and organizational boundaries. In particular, we devise software analysis tools as services that can be accessed and composed over the Internet. These distributed services shall be widely accessible through a software analysis broker where organizations and research groups can register and share their tools. To enable (semi)-automat...
Regression analysis by example
Chatterjee, Samprit
2012-01-01
Praise for the Fourth Edition: ""This book is . . . an excellent source of examples for regression analysis. It has been and still is readily readable and understandable."" -Journal of the American Statistical Association Regression analysis is a conceptually simple method for investigating relationships among variables. Carrying out a successful application of regression analysis, however, requires a balance of theoretical results, empirical rules, and subjective judgment. Regression Analysis by Example, Fifth Edition has been expanded
Computational movement analysis
Laube, Patrick
2014-01-01
This SpringerBrief discusses the characteristics of spatiotemporal movement data, including uncertainty and scale. It investigates three core aspects of Computational Movement Analysis: Conceptual modeling of movement and movement spaces, spatiotemporal analysis methods aiming at a better understanding of movement processes (with a focus on data mining for movement patterns), and using decentralized spatial computing methods in movement analysis. The author presents Computational Movement Analysis as an interdisciplinary umbrella for analyzing movement processes with methods from a range of fi
Fitzmaurice, Garrett M; Ware, James H
2012-01-01
Praise for the First Edition "". . . [this book] should be on the shelf of everyone interested in . . . longitudinal data analysis.""-Journal of the American Statistical Association Features newly developed topics and applications of the analysis of longitudinal data Applied Longitudinal Analysis, Second Edition presents modern methods for analyzing data from longitudinal studies and now features the latest state-of-the-art techniques. The book emphasizes practical, rather than theoretical, aspects of methods for the analysis of diverse types of lo
This book gives descriptions of use and method analysis, which includes handling of glass tools, boiling, filter of liquid, distillation method and a sampling process, evaporation and dry, reagent solution and concentration. It explains waster quality analysis with quantitative analysis, weight analysis and solvent extraction. It also introduces flow measurement, and test method of each item like hydrogen ion concentration, ammoniacal nitrogen, phosphate, chrome, cadmium, alkyl mercury and number of colitis germs.
Yuan, Ying; MacKinnon, David P.
2009-01-01
This article proposes Bayesian analysis of mediation effects. Compared to conventional frequentist mediation analysis, the Bayesian approach has several advantages. First, it allows researchers to incorporate prior information into the mediation analysis, thus potentially improving the efficiency of estimates. Second, under the Bayesian mediation analysis, inference is straightforward and exact, which makes it appealing for studies with small samples. Third, the Bayesian approach is conceptua...
Corliss, William R.
1968-01-01
In activation analysis, a sample of an unknown material is first irradiated (activated) with nuclear particles. In practice these nuclear particles are almost always neutrons. The success of activation analysis depends upon nuclear reactions which are completely independent of an atom's chemical associations. The value of activation analysis as a research tool was recognized almost immediately upon the discovery of artificial radioactivity. This book discusses activation analysis experiments, applications and technical considerations.
[Transcriptome analysis and epigenetic analysis during osteoclastogenesis].
Nakamura, Shinya; Tanaka, Sakae
2016-04-01
The importance of receptor activator of nuclear factor-κB ligand(RANKL)during osteoclastogenesis was discovered in 1998. After that Nfatc1, downstream gene of RANKL-RANK signaling, was identified as a master regulator of osteoclastogenesis by transcriptome analysis. In recent years, with the advancement of epigenetic analysis method and big data analysis technology, epigenetic analysis about osteoclastogenesis gradually progresses. Some papers using H3K4me3 and H3K27me3 histone modification change data, DNase-seq data and formaldehyde-assisted isolation of regulatory elements(FAIRE)-seq data during osteoclastogenesis were published recently. It will probably contribute to elucidate the crosstalk between osteoclasts and osteoblasts, osteocytes or chondrocytes in the future. PMID:27013627
Cuesta, Hector
2013-01-01
Each chapter of the book quickly introduces a key 'theme' of Data Analysis, before immersing you in the practical aspects of each theme. You'll learn quickly how to perform all aspects of Data Analysis.Practical Data Analysis is a book ideal for home and small business users who want to slice & dice the data they have on hand with minimum hassle.
Hibbert, DBrynn
2005-01-01
Based on D Brynn Hibbert''s lectures on data analysis to undergraduates and graduate students, this book covers topics including measurements, means and confidence intervals, hypothesis testing, analysis of variance, and calibration models. It is meant as an entry level book targeted at learning and teaching undergraduate data analysis.
Yuan, Ying; MacKinnon, David P.
2009-01-01
In this article, we propose Bayesian analysis of mediation effects. Compared with conventional frequentist mediation analysis, the Bayesian approach has several advantages. First, it allows researchers to incorporate prior information into the mediation analysis, thus potentially improving the efficiency of estimates. Second, under the Bayesian…
Sparse exploratory factor analysis
Fontanella, Sara; Trendafilov, Nickolay; Adachi, Kohei
2014-01-01
Sparse principal component analysis is a very active research area in the last decade. In the same time, there are very few works on sparse factor analysis. We propose a new contribution to the area by exploring a procedure for sparse factor analysis where the unknown parameters are found simultaneously.
2010-10-01
... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Policy. 2115.402 Section... NEGOTIATION Contract Pricing 2115.402 Policy. Pricing of FEGLI Program premium rates is governed by 5 U.S.C... analysis policies and procedures. To the extent that reasonable or good faith actuarial estimates are...
Harmonic and spectral analysis
Székelyhidi, László
2014-01-01
This book provides a modern introduction to harmonic analysis and synthesis on topological groups. It serves as a guide to the abstract theory of Fourier transformation. For the first time, it presents a detailed account of the theory of classical harmonic analysis together with the recent developments in spectral analysis and synthesis. Sample Chapter(s)Chapter 1: Duality of Finite Abelian Groups (254 KB) Contents:Abstract Harmonic Analysis:Duality of Finite Abelian GroupsHarmonic Analysis on Finite Abelian GroupsSet
Foundations of mathematical analysis
Johnsonbaugh, Richard
2010-01-01
This classroom-tested volume offers a definitive look at modern analysis, with views of applications to statistics, numerical analysis, Fourier series, differential equations, mathematical analysis, and functional analysis. Upper-level undergraduate students with a background in calculus will benefit from its teachings, along with beginning graduate students seeking a firm grounding in modern analysis. A self-contained text, it presents the necessary background on the limit concept, and the first seven chapters could constitute a one-semester introduction to limits. Subsequent chapters discuss
Mathematical analysis fundamentals
Bashirov, Agamirza
2014-01-01
The author's goal is a rigorous presentation of the fundamentals of analysis, starting from elementary level and moving to the advanced coursework. The curriculum of all mathematics (pure or applied) and physics programs include a compulsory course in mathematical analysis. This book will serve as can serve a main textbook of such (one semester) courses. The book can also serve as additional reading for such courses as real analysis, functional analysis, harmonic analysis etc. For non-math major students requiring math beyond calculus, this is a more friendly approach than many math-centric o
Analysis in usability evaluations
Følstad, Asbjørn; Lai-Chong Law, Effie; Hornbæk, Kasper Anders Søren
2010-01-01
While the planning and implementation of usability evaluations are well described in the literature, the analysis of the evaluation data is not. We present interviews with 11 usability professionals on how they conduct analysis, describing the resources, collaboration, creation of recommendations......, and prioritization involved. The interviews indicate a lack of structure in the analysis process and suggest activities, such as generating recommendations, that are unsupported by existing methods. We discuss how to better support analysis, and propose four themes for future research on analysis in...... usability evaluations....
Gabriel Data Analysis (GDA): from data analysis to food analysis
OLIVE, Gilles
2011-01-01
GDA is a software belonging to the Gabriel package and is devoted to data analysis. Year after year some new features have been introduced and the latest introductions are more dedicated to food. GDA is built around modules and we describe here the most widely used in food chemistry. GDA can be obtained free of charge upon request.
Split-course accelerated therapy in head and neck cancer: an analysis of toxicity
Purpose: To retrospectively assess a protocol of split-course accelerated radiation therapy (SCAT) for selected head and neck cancers. Methods and Materials: SCAT consisted of 1.8 Gy per fraction administered twice daily with a minimum gap between fractions of 6 h. The treatment protocol prescribed an initial 16 fractions followed by a planned 5 to 12 day break, and then a further 20 to 22 fractions for a total dose ranging from 64.8 to 72 Gy delivered in 5 to 6 weeks. Results: Twenty-eight patients received SCAT for histologically confirmed head and neck cancer between January 1987 and August 1991. All patients were followed up until December 1, 1993. The mean potential follow-up time was 4.2 years (range: 2.9-6.2 years). All patients completed the treatment protocol. Thirteen tumors were laryngeal in origin, eight hypopharyngeal, four paranasal sinus, and three oropharyngeal. There were no Stage I, three Stage II, nine Stage III, and 12 Stage IV tumors. Four tumors were not staged (two paranasal sinus cancers and two surgical recurrences). Early and late toxicities were moderate to severe. Confluent mucositis was experienced by 27 of the 28 patients (96%). One patient required a prolonged midtreatment break of 24 days. Nine patients (32%) required narcotic analgesia for pain relief. Eleven patients (39%) required hospitalization for nasogastric feeding or pain control. The median length of hospital stay was 14 days (range 7-98 days). The actuarial rate of severe late toxicity at 3 years was 47% (standard error (SE) = 13%). A complete tumor response was achieved in 86% of patients. The actuarial local control rate at 3 years was 43% (SE = 11%) and the actuarial survival rate at 3 years was 25% (SE = 8%). Conclusion: Given the encouraging complete response rate and local control for such advanced tumors, SCAT for locoregionally advanced tumors merits further investigation. However, because of the significant late toxicity observed, the total dose, interfraction
Amir Farbin
The ATLAS Analysis Model is a continually developing vision of how to reconcile physics analysis requirements with the ATLAS offline software and computing model constraints. In the past year this vision has influenced the evolution of the ATLAS Event Data Model, the Athena software framework, and physics analysis tools. These developments, along with the October Analysis Model Workshop and the planning for CSC analyses have led to a rapid refinement of the ATLAS Analysis Model in the past few months. This article introduces some of the relevant issues and presents the current vision of the future ATLAS Analysis Model. Event Data Model The ATLAS Event Data Model (EDM) consists of several levels of details, each targeted for a specific set of tasks. For example the Event Summary Data (ESD) stores calorimeter cells and tracking system hits thereby permitting many calibration and alignment tasks, but will be only accessible at particular computing sites with potentially large latency. In contrast, the Analysis...
Bøving, Kristian Billeskov; Simonsen, Jesper
2004-01-01
This article documents how log analysis can inform qualitative studies concerning the usage of web-based information systems (WIS). No prior research has used http log files as data to study collaboration between multiple users in organisational settings. We investigate how to perform http log...... analysis; what http log analysis says about the nature of collaborative WIS use; and how results from http log analysis may support other data collection methods such as surveys, interviews, and observation. The analysis of log files initially lends itself to research designs, which serve to test...... hypotheses using a quantitative methodology. We show that http log analysis can also be valuable in qualitative research such as case studies. The results from http log analysis can be triangulated with other data sources and for example serve as a means of supporting the interpretation of interview data. It...
Washington Safety Management Solutions, LLC developed web-based software to improve the efficiency and consistency of hazard identification and analysis, control selection and classification, and to standardize analysis reporting at Savannah River Site. In the new nuclear age, information technology provides methods to improve the efficiency of the documented safety analysis development process which includes hazard analysis activities. This software provides a web interface that interacts with a relational database to support analysis, record data, and to ensure reporting consistency. A team of subject matter experts participated in a series of meetings to review the associated processes and procedures for requirements and standard practices. Through these meetings, a set of software requirements were developed and compiled into a requirements traceability matrix from which software could be developed. The software was tested to ensure compliance with the requirements. Training was provided to the hazard analysis leads. Hazard analysis teams using the software have verified its operability. The software has been classified as NQA-1, Level D, as it supports the analysis team but does not perform the analysis. The software can be transported to other sites with alternate risk schemes. The software is being used to support the development of 14 hazard analyses. User responses have been positive with a number of suggestions for improvement which are being incorporated as time permits. The software has enforced a uniform implementation of the site procedures. The software has significantly improved the efficiency and standardization of the hazard analysis process
Establishing PIXE analysis conditions for sweat analysis
This paper describes a technical analysis of biological samples of sweat by proton induced X-ray emission (hereafter referred to as PIXE). The choice of the irradiation conditions, the preparation of the targets, and the processing treatment of spectra are described. Two excitation systems were used, one under vacuum and the other in atmospheric pressure under helium. Advantages and disadvantages of the two systems are described and detection limits obtained in both cases are presented. A comparison with results obtained by X-ray analysis induced by radioactive sources is made. (orig.)
Cost benefit analysis cost effectiveness analysis
The comparison of various protection options in order to determine which is the best compromise between cost of protection and residual risk is the purpose of the ALARA procedure. The use of decision-aiding techniques is valuable as an aid to selection procedures. The purpose of this study is to introduce two rather simple and well known decision aiding techniques: the cost-effectiveness analysis and the cost-benefit analysis. These two techniques are relevant for the great part of ALARA decisions which need the use of a quantitative technique. The study is based on an hypothetical case of 10 protection options. Four methods are applied to the data
Introduction to reliability analysis
Reliability analysis is concerned with the analysis of devices and systems whose individual components are prone to failure. This textbook presents an introduction to reliability analysis of repairable and nonrepairable systems. It is based on courses given to both undergraduate and graduate students of engineering and statistics as well as in workshops for professional engineers and scientists. The book concentrates on the methodology of the subject and on understanding theoretical results rather than on its theoretical development. An intrinsic aspect of reliability analysis is that the failure of components is best modelled using techniques drawn from probability and statistics. The author covers all the basic concepts required from these subjects and covers the main modern reliability analysis techniques thoroughly. These include: the graphical analysis of life data, maximum likelihood estimation, and Bayesian estimation. Throughout, the emphsis is on the practicalities of the subject with numerous examples drawn from industrial and engineering settings. (orig.) With 50 figs
This book provides an in-depth introduction and overview of current research in computational music analysis. Its seventeen chapters, written by leading researchers, collectively represent the diversity as well as the technical and philosophical sophistication of the work being done today in this...... well-established theories in music theory and analysis, such as Forte's pitch-class set theory, Schenkerian analysis, the methods of semiotic analysis developed by Ruwet and Nattiez, and Lerdahl and Jackendoff's Generative Theory of Tonal Music. The book is divided into six parts, covering...... music analysis, the book provides an invaluable resource for researchers, teachers and students in music theory and analysis, computer science, music information retrieval and related disciplines. It also provides a state-of-the-art reference for practitioners in the music technology industry....
Vatrapu, Ravi; Mukkamala, Raghava Rao; Hussain, Abid;
2016-01-01
automata and agent-based modeling). However, when it comes to organizational and societal units of analysis, there exists no approach to conceptualize, model, analyze, explain, and predict social media interactions as individuals' associations with ideas, values, identities, and so on. To address......Current analytical approaches in computational social science can be characterized by four dominant paradigms: text analysis (information extraction and classification), social network analysis (graph theory), social complexity analysis (complex systems science), and social simulations (cellular...... this limitation, based on the sociology of associations and the mathematics of set theory, this paper presents a new approach to big data analytics called social set analysis. Social set analysis consists of a generative framework for the philosophies of computational social science, theory of social data...
The heat transport systems of MONJU are three main heat transport loops, each loop consist of the primary, the secondary loop and the water-steam system, in addition, the auxiliary cooling system. These systems are under the influence one another on plant transient. So it is important to evaluate the flow and heat characteristics of the heat transport systems on calculating plant transient. We made the plant dynamic analysis codes of MONJU to calculate the plant transient analysis and evaluate the plant characteristics by the disturbance on the on-power operation and the performance of the plant control systems. In this paper, one of the main plant dynamic simulation code of MONJU, the calculation conditions on analysis, the plant safety analysis, the plant stability analysis and the plant thermal transient analysis are discribed. (author)
Purpose: ABMT is increasingly being utilized in the treatment of relapsed and refractory NHL. Pulmonary toxicity is often dose-limiting for conditioning regimens that contain total body irradiation (TBI). We analyze the risk factors for post-ABMT pulmonary toxicity in a single institution experience. Materials and Methods: 133 consecutive patients underwent conditioning with TBI ((12.5-15 Gy(10-12)) fractions over 4 days, with single HVL lung blocking), etoposide (VP16) (750 mg/m2) and high-dose cyclophosphamide (Cy) (120 mg/kg) or TBI/Cy alone followed by ABMT for relapsed or primary refractory NHL from 1982-1993. Boost RT ((12-20 Gy(4-10)) fractions) was given to 87 patients with bulky or residual disease just prior to ABMT Results: Median follow-up from ABMT of surviving patients is 4.8 years. The actuarial risk of grade (Gr) 3 or greater pulmonary toxicity at 3 months, 1 year, and 5 years was 48 %, 60 %, and 74 %, and for Gr 5 (fatal) toxicity: 28%, 32 %, and 36 %, respectively. Half of all cases were infectious: 21 were bacterial, including 2 Tb and 6 presumed bacterial (0-51 months post-ABMT, 4 month median, 2 fatal), 7 aspergillus (0.3-5 months, 5 fatal), 5 PCP (2-14 months, 1 fatal), 3 CMV (0.3-22 months, 1 fatal), 1 HSV (0.3 months, fatal). Of non-infectious causes, 21 patients had pulmonary hemorrhage (all but 2 cases seen within 15 days post-ABMT, 19 fatal), 15 idiopathic pneumonitis (0-3 months, 4 fatal), and one late fatal pulmonary fibrosis (onset at 46 months). Significant factors (p 25K (> 25 days vs. ≤ 25 days, n=112 evaluable patients, i.e. 1 month survivors, p=0.0004), lung involvement by tumor (n=16, p=0.001), conditioning regimen (Cy-VP16 vs. Cy alone, p=0.009), mediastinal (med) boost (n=48, p=0.03), TBI dose (> 1320 cGy vs. ≤ 1320 cGy, p=0.05). Cox proportional hazards model which included all covariates with p<0.20 in univariate analysis revealed platelet engraftment (p=0.0004) and lung involvement (p=0.05) as independently significant
Kosmidis, Kosmas; Kalampokis, Alkiviadis; Argyrakis, Panos
2006-01-01
We use the Detrended Fluctuation Analysis (DFA) and the Grassberger-Proccacia analysis (GP) methods in order to study language characteristics. Despite that we construct our signals using only word lengths or word frequencies, excluding in this way huge amount of information from language, the application of Grassberger- Proccacia (GP) analysis indicates that linguistic signals may be considered as the manifestation of a complex system of high dimensionality, different from random signals or ...
Verhoosel, C.V.; Gutiérrez, M. A.; Hulshoff, S.J.
2006-01-01
The field of fluid-structure interaction is combined with the field of stochastics to perform a stochastic flutter analysis. Various methods to directly incorporate the effects of uncertainties in the flutter analysis are investigated. The panel problem with a supersonic fluid flowing over it is considered as a testcase. The stochastic moments (mean, standard deviation, etc.) of the flutter point are computed by an uncertainty analysis. Sensitivity-based methods are used to determine the stoc...
Procházková, Gabriela
2014-01-01
The Bachelor thesis focuses on the analysis of the marketing mix which was applied to a company called Bill Ltd. The theoretical part focuses on the general description of the marketing mix and its individual elements. In the practical part is mentioned the history and present of the company Billa Ltd. It also includes a specific analysis of individual elements of the marketing mix of the company Bill Ltd. and analysis of the results of the electronic questioning, that focuses on br...
Skrypnyuk, Nataliya; Nielson, Flemming; Pilegaard, Henrik
We present the ongoing work on the pathway analysis of a stochastic calculus. Firstly we present a particular stochastic calculus that we have chosen for our modeling - the Interactive Markov Chains calculus, IMC for short. After that we specify a few restrictions that we have introduced into the...... syntax of IMC in order to make our analysis feasible. Finally we describe the analysis itself together with several theoretical results that we have proved for it....
Ranganath, Rajesh; Perotte, Adler; Elhadad, Noémie; Blei, David
2016-01-01
The electronic health record (EHR) provides an unprecedented opportunity to build actionable tools to support physicians at the point of care. In this paper, we investigate survival analysis in the context of EHR data. We introduce deep survival analysis, a hierarchical generative approach to survival analysis. It departs from previous approaches in two primary ways: (1) all observations, including covariates, are modeled jointly conditioned on a rich latent structure; and (2) the observation...
Our analysis program LULU has proven very useful in all stages of experiment analysis, from prerun detector debugging through final data reduction. It has solved our problem of having arbitrary word length events and is easy enough to use that many separate experimenters are now analyzing with LULU. The ability to use the same software for all stages of experiment analysis greatly eases the programming burden. We may even get around to making the graphics elegant someday
Crisan, Dan
2011-01-01
"Stochastic Analysis" aims to provide mathematical tools to describe and model high dimensional random systems. Such tools arise in the study of Stochastic Differential Equations and Stochastic Partial Differential Equations, Infinite Dimensional Stochastic Geometry, Random Media and Interacting Particle Systems, Super-processes, Stochastic Filtering, Mathematical Finance, etc. Stochastic Analysis has emerged as a core area of late 20th century Mathematics and is currently undergoing a rapid scientific development. The special volume "Stochastic Analysis 2010" provides a sa
The authors present a treatment of human reliability analysis incorporating an introduction to probabilistic risk assessment for nuclear power generating stations. They treat the subject according to the framework established for general systems theory. Draws upon reliability analysis, psychology, human factors engineering, and statistics, integrating elements of these fields within a systems framework. Provides a history of human reliability analysis, and includes examples of the application of the systems approach
Mastering Clojure data analysis
Rochester, Eric
2014-01-01
This book consists of a practical, example-oriented approach that aims to help you learn how to use Clojure for data analysis quickly and efficiently.This book is great for those who have experience with Clojure and who need to use it to perform data analysis. This book will also be hugely beneficial for readers with basic experience in data analysis and statistics.
Möncke, Ulrich R.
1986-01-01
This paper specifies the theoretical basis for the implementation of different generators of the OPTRAN system. Grammar Flow analysis transports the techniques of data flow analysis to the meta level of compiler construction. The analogon to the states in data flow analysis are the syntax trees together with some information, which is associated with trees by propagation functions. One example is the association of characteristic graphs, another example the association of sets of matching tre...
Machine Fault Signature Analysis
Mulchandani, K. B.; A.K. Wadhwani; Pratesh Jayaswal
2008-01-01
The objective of this paper is to present recent developments in the field of machine fault signature analysis with particular regard to vibration analysis. The different types of faults that can be identified from the vibration signature analysis are, for example, gear fault, rolling contact bearing fault, journal bearing fault, flexible coupling faults, and electrical machine fault. It is not the intention of the authors to attempt to provide a detailed coverage of all the faults while deta...
Johnson, Andrew
2009-01-01
This essay provides a detailed strategic analysis of 3rdWhale, a Vancouver-based start-up in the sustainability sector, along with an analysis of the smartphone applications industry. Porter?s five forces model is used to perform an industry analysis of the smartphone application industry and identify key success factors for application developers. Using the identified factors, 3rdWhale is compared to its indirect competitors to identify opportunities and threats and produce a range of strate...
Circuit analysis with Multisim
Baez-Lopez, David
2011-01-01
This book is concerned with circuit simulation using National Instruments Multisim. It focuses on the use and comprehension of the working techniques for electrical and electronic circuit simulation. The first chapters are devoted to basic circuit analysis.It starts by describing in detail how to perform a DC analysis using only resistors and independent and controlled sources. Then, it introduces capacitors and inductors to make a transient analysis. In the case of transient analysis, it is possible to have an initial condition either in the capacitor voltage or in the inductor current, or bo
Textile Technology Analysis Lab
Federal Laboratory Consortium — The Textile Analysis Labis built for evaluating and characterizing the physical properties of an array of textile materials, but specifically those used in aircrew...
Hazard Analysis Database Report
The Hazard Analysis Database was developed in conjunction with the hazard analysis activities conducted in accordance with DOE-STD-3009-94, Preparation Guide for U S . Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports, for HNF-SD-WM-SAR-067, Tank Farms Final Safety Analysis Report (FSAR). The FSAR is part of the approved Authorization Basis (AB) for the River Protection Project (RPP). This document describes, identifies, and defines the contents and structure of the Tank Farms FSAR Hazard Analysis Database and documents the configuration control changes made to the database. The Hazard Analysis Database contains the collection of information generated during the initial hazard evaluations and the subsequent hazard and accident analysis activities. The Hazard Analysis Database supports the preparation of Chapters 3 ,4 , and 5 of the Tank Farms FSAR and the Unreviewed Safety Question (USQ) process and consists of two major, interrelated data sets: (1) Hazard Analysis Database: Data from the results of the hazard evaluations, and (2) Hazard Topography Database: Data from the system familiarization and hazard identification
2010-01-01
Finite element analysis is an engineering method for the numerical analysis of complex structures. This book provides a bird's eye view on this very broad matter through 27 original and innovative research studies exhibiting various investigation directions. Through its chapters the reader will have access to works related to Biomedical Engineering, Materials Engineering, Process Analysis and Civil Engineering. The text is addressed not only to researchers, but also to professional engineers, engineering lecturers and students seeking to gain a better understanding of where Finite Element Analysis stands today.
Chemical Security Analysis Center
Federal Laboratory Consortium — In 2006, by Presidential Directive, DHS established the Chemical Security Analysis Center (CSAC) to identify and assess chemical threats and vulnerabilities in the...
HIRENASD analysis Information Package
National Aeronautics and Space Administration — Updated November 2, 2011 Contains summary information and analysis condition details for the Aeroelastic Prediction Workshop Information plotted in this package is...
Risk analysis methodology survey
Batson, Robert G.
1987-01-01
NASA regulations require that formal risk analysis be performed on a program at each of several milestones as it moves toward full-scale development. Program risk analysis is discussed as a systems analysis approach, an iterative process (identification, assessment, management), and a collection of techniques. These techniques, which range from simple to complex network-based simulation were surveyed. A Program Risk Analysis Handbook was prepared in order to provide both analyst and manager with a guide for selection of the most appropriate technique.
Sensitivity and uncertainty analysis
Cacuci, Dan G; Navon, Ionel Michael
2005-01-01
As computer-assisted modeling and analysis of physical processes have continued to grow and diversify, sensitivity and uncertainty analyses have become indispensable scientific tools. Sensitivity and Uncertainty Analysis. Volume I: Theory focused on the mathematical underpinnings of two important methods for such analyses: the Adjoint Sensitivity Analysis Procedure and the Global Adjoint Sensitivity Analysis Procedure. This volume concentrates on the practical aspects of performing these analyses for large-scale systems. The applications addressed include two-phase flow problems, a radiative c
Sørensen, Olav Jull
2009-01-01
The review presents the book International Market Analysis: Theories and Methods, written by John Kuiada, professor at Centre of International Business, Department of Business Studies, Aalborg University. The book is refreshingly new in its way of looking at a classical problem. It looks at market...... analysis from the point of vie of ways of thinking about markets. Furthermore, the book includes the concept of learning in the analysis of markets og how the way we understand business reality influneces our choice of methodology for market analysis....
The Krsko Source Term Analysis (STA) has been provided as integral part of the Krsko Individual Plant Examination Project (IPE) Level 2 (Containment Analysis). Based on its own definition, the STA quantifies the magnitude, time dependence and composition of the fission product releases which characterize each Release Category (RC). The Krsko STA also addresses the definition of each RC, identification and the choice of dominant accident sequences within a release category, analysis of the representative accident sequences using MAAP 3.OB (Modular Accident Analysis Program) revision 18 to estimate the source term characteristic and discussion of identified major areas of uncertainty. (author)
Murty, PSR
2007-01-01
Power system analysis is a pre-requisite course for electrical engineering students. This book introduces concepts of a power system, network model faults and analysis and the primitive network stability. It also deals with graph theory relevant to various incidence matrices, building of network matrices and power flow studies. It further discusses with short circuit analysis, unbalanced fault analysis and power system stability problems, such as, steady state stability, transient stability and dynamic stability. Salient Features: Number of worked examples are followed after explaining theory
Federal Laboratory Consortium — FUNCTION: Uses state-of-the-art instrumentation for qualitative and quantitative analysis of organic and inorganic compounds, and biomolecules from gas, liquid, and...
Thermogravimetric Analysis Laboratory
Federal Laboratory Consortium — At NETL’s Thermogravimetric Analysis Laboratory in Morgantown, WV, researchers study how chemical looping combustion (CLC) can be applied to fossil energy systems....
Hazard Analysis Database Report
GRAMS, W.H.
2000-12-28
The Hazard Analysis Database was developed in conjunction with the hazard analysis activities conducted in accordance with DOE-STD-3009-94, Preparation Guide for U S . Department of Energy Nonreactor Nuclear Facility Safety Analysis Reports, for HNF-SD-WM-SAR-067, Tank Farms Final Safety Analysis Report (FSAR). The FSAR is part of the approved Authorization Basis (AB) for the River Protection Project (RPP). This document describes, identifies, and defines the contents and structure of the Tank Farms FSAR Hazard Analysis Database and documents the configuration control changes made to the database. The Hazard Analysis Database contains the collection of information generated during the initial hazard evaluations and the subsequent hazard and accident analysis activities. The Hazard Analysis Database supports the preparation of Chapters 3 ,4 , and 5 of the Tank Farms FSAR and the Unreviewed Safety Question (USQ) process and consists of two major, interrelated data sets: (1) Hazard Analysis Database: Data from the results of the hazard evaluations, and (2) Hazard Topography Database: Data from the system familiarization and hazard identification.
National Oceanic and Atmospheric Administration, Department of Commerce — Space Weather Analysis archives are model output of ionospheric, thermospheric and magnetospheric particle populations, energies and electrodynamics
Machine Fault Signature Analysis
K. B. Mulchandani
2008-03-01
Full Text Available The objective of this paper is to present recent developments in the field of machine fault signature analysis with particular regard to vibration analysis. The different types of faults that can be identified from the vibration signature analysis are, for example, gear fault, rolling contact bearing fault, journal bearing fault, flexible coupling faults, and electrical machine fault. It is not the intention of the authors to attempt to provide a detailed coverage of all the faults while detailed consideration is given to the subject of the rolling element bearing fault signature analysis.
Risk Analysis of Marine Structures
Hansen, Peter Friis
1998-01-01
Basic concepts of risk analysis is introduced. Formulation and analysis of fault and event trees are treated.......Basic concepts of risk analysis is introduced. Formulation and analysis of fault and event trees are treated....
Total skin electron irradiation for mycosis fungoides: failure analysis and prognostic factors
From 1970 to 1980, 106 patients with mycosis fungoides received total skin electron irradiation to full tolerance. The majority received 30 Gy of 3 MeV electrons in 12 treatments over three weeks. Eighty-eight patients had received prior therapy. At five years, actuarial survival is 66.7% and disease-free survival 21.4%. The median time to relapse is 12 months; prolonged survival is seen only with complete response. In advanced stages, complete response is more likely with doses over 25 Gy (80 vs 50%). First recurrences were predominently in sites of previous involvement. Death resulted mainly from extracutaneous dissemination or failure to induce remission. Complications of the therapy are discussed
2011-12-12
... and Actuarial Information Reporting AGENCY: Pension Benefit Guaranty Corporation. ACTION: Notice of... Reduction Act, of its ] collection of information for annual financial and actuarial information reporting... and actuarial information to PBGC under certain circumstances. PBGC's regulation on Annual...
Advanced Analysis Environments - Summary
This is a summary of the panel discussion on Advanced Analysis Environments. Rene Brun, Tony Johnson, and Lassi Tuura shared their insights about the trends and challenges in analysis environments. This paper contains the initial questions, a summary of the speakers' presentation, and the questions asked by the audience
Interaction Analysis and Supervision.
Amidon, Edmund
This paper describes a model that uses interaction analysis as a tool to provide feedback to a teacher in a microteaching situation. The author explains how interaction analysis can be used for teacher improvement, describes the category system used in the model, the data collection methods used, and the feedback techniques found in the model. (JF)
Spool assembly support analysis
This document provides the wind/seismic analysis and evaluation for the pump pit spool assemblies. Hand calculations were used for the analysis. UBC, AISC, and load factors were used in this evaluation. The results show that the actual loads are under the allowable loads and all requirements are met
MEAD retrospective analysis report
Hasager, Charlotte Bay; Carstensen, J.; Frohn, L.M.;
2003-01-01
The retrospective analysis investigates links between atmospheric nitrogen deposition and algal bloom development in the Kattegat Sea from April to September 1989-1999. The analysis is based on atmospheric deposition model results from the ACDEP model,hydrodynamic deep-water flux results, phytopl...
Damkilde, Lars
2007-01-01
Limit State analysis has a long history and many prominent researchers have contributed. The theoretical foundation is based on the upper- and lower-bound theorems which give a very comprehensive and elegant formulation on complicated physical problems. In the pre-computer age Limit State analysis...
Shot loading platform analysis
This document provides the wind/seismic analysis and evaluation for the shot loading platform. Hand calculations were used for the analysis. AISC and UBC load factors were used in this evaluation. The results show that the actual loads are under the allowable loads and all requirements are met
Structural analysis for Diagnosis
Izadi-Zamanabadi, Roozbeh; Blanke, M.
2001-01-01
Aiming at design of algorithms for fault diagnosis, structural analysis of systems offers concise yet easy overall analysis. Graph-based matching, which is the essential technique to obtain redundant information for diagnosis, is re-considered in this paper. Matching is re-formulated as a problem...
Food risk analysis is a holistic approach to food safety because it considers all aspects of the problem. Risk assessment modeling is the foundation of food risk analysis. Proper design and simulation of the risk assessment model is important to properly predict and control risk. Because of knowl...
Bunke, H; Baird, H
1994-01-01
Interest in the automatic processing and analysis of document images has been rapidly increasing during the past few years. This book addresses the different subfields of document image analysis, including preprocessing and segmentation, form processing, handwriting recognition, line drawing and map processing, and contextual processing.
Analysis of Design Documentation
Hansen, Claus Thorp
1998-01-01
has been established where we seek to identify useful design work patterns by retrospective analyses of documentation created during design projects. This paper describes the analysis method, a tentatively defined metric to evaluate identified work patterns, and presents results from the first...... analysis accomplished....
Bemman, Brian; Meredith, David
Sheer Pluck (1984), a twelve-tone composition for guitar by Milton Babbitt (1916–2011). This analysis focuses on the all-partition array structure on which the piece is based. Having pre- sented this analysis, we formalize some constraints on the structure of the piece and explore some computational...
Bass, Roger
2010-01-01
Zen's challenge for behavior analysis is to explain a repertoire that renders analysis itself meaningless--a result following not from scientific or philosophical arguments but rather from a unique verbal history generated by Zen's methods. Untying Zen's verbal knots suggests how meditation's and koans' effects on verbal behavior contribute to…
Donahue, Craig J.; Rais, Elizabeth A.
2009-01-01
This lab experiment illustrates the use of thermogravimetric analysis (TGA) to perform proximate analysis on a series of coal samples of different rank. Peat and coke are also examined. A total of four exercises are described. These are dry exercises as students interpret previously recorded scans. The weight percent moisture, volatile matter,…
Interactive Controls Analysis (INCA)
Bauer, Frank H.
1989-01-01
Version 3.12 of INCA provides user-friendly environment for design and analysis of linear control systems. System configuration and parameters easily adjusted, enabling INCA user to create compensation networks and perform sensitivity analysis in convenient manner. Full complement of graphical routines makes output easy to understand. Written in Pascal and FORTRAN.
Josefsen, Knud; Nielsen, Henrik
2011-01-01
Northern blotting analysis is a classical method for analysis of the size and steady-state level of a specific RNA in a complex sample. In short, the RNA is size-fractionated by gel electrophoresis and transferred by blotting onto a membrane to which the RNA is covalently bound. Then, the membrane...... closing the gap to the more laborious nuclease protection experiments....
Analysis of Industrial Wastewaters.
Mancy, K. H.; Weber, W. J., Jr.
A comprehensive, documented discussion of certain operating principles useful as guidelines for the analysis of industrial wastewaters is presented. Intended primarily for the chemist, engineer, or other professional person concerned with all aspects of industrial wastewater analysis, it is not to be considered as a substitute for standard manuals…
The complexity of instrumentation sometimes requires data analysis to be done before the result is presented to the control room. This tutorial reviews some of the theoretical assumptions underlying the more popular forms of data analysis and presents simple examples to illuminate the advantages and hazards of different techniques
Liberdová, I.
2015-01-01
This article is focused on the dynamic drawing analysis. It deals with temporal segmentation methods for hand-drawn pictures. The automatic vectorization of segmentation results is considered as well. Dynamic drawing analysis may significantly improves tracing drawing test utilization in the clinical physiology trials.
Structural analysis for diagnosis
Izadi-Zamanabadi, Roozbeh; Blanke, M.
2002-01-01
Aiming at design of algorithms for fault diagnosis, structural analysis of systems offers concise yet easy overall analysis. Graph-based matching, which is the essential tech-nique to obtain redundant information for diagnosis, is reconsidered in this paper. Matching is reformulated as a problem of...
Louis Kaplow; Steven Shavell
1999-01-01
This entry for the forthcoming The New Palgrave Dictionary of Economics (Second Edition) surveys the economic analysis of five primary fields of law: property law; liability for accidents; contract law; litigation; and public enforcement and criminal law. It also briefly considers some criticisms of the economic analysis of law.
The objective of SCK-CEN's programme on reactor safety is to develop expertise in probabilistic and deterministic reactor safety analysis. The research programme consists of two main activities, in particular the development of software for reliability analysis of large systems and participation in the international PHEBUS-FP programme for severe accidents. Main achievements in 1999 are reported
Chakravorti, Sivaji
2015-01-01
This book prepares newcomers to dive into the realm of electric field analysis. The book details why one should perform electric field analysis and what are its practical implications. It emphasizes both the fundamentals and modern computational methods of electric machines. The book covers practical applications of the numerical methods in high voltage equipment, including transmission lines, power transformers, cables, and gas insulated systems.
The purpose of this accident safety analysis is to document in detail, analyses whose results were reported in summary form in the K Basins Safety Analysis Report WHC-SD-SNF-SAR-001. The safety analysis addressed the potential for release of radioactive and non-radioactive hazardous material located in the K Basins and their supporting facilities. The safety analysis covers the hazards associated with normal K Basin fuel storage and handling operations, fuel encapsulation, sludge encapsulation, and canister clean-up and disposal. After a review of the Criticality Safety Evaluation of the K Basin activities, the following postulated events were evaluated: Crane failure and casks dropped into loadout pit; Design basis earthquake; Hypothetical loss of basin water accident analysis; Combustion of uranium fuel following dryout; Crane failure and cask dropped onto floor of transfer area; Spent ion exchange shipment for burial; Hydrogen deflagration in ion exchange modules and filters; Release of Chlorine; Power availability and reliability; and Ashfall
Porten, D.R.; Crowe, R.D.
1994-12-16
The purpose of this accident safety analysis is to document in detail, analyses whose results were reported in summary form in the K Basins Safety Analysis Report WHC-SD-SNF-SAR-001. The safety analysis addressed the potential for release of radioactive and non-radioactive hazardous material located in the K Basins and their supporting facilities. The safety analysis covers the hazards associated with normal K Basin fuel storage and handling operations, fuel encapsulation, sludge encapsulation, and canister clean-up and disposal. After a review of the Criticality Safety Evaluation of the K Basin activities, the following postulated events were evaluated: Crane failure and casks dropped into loadout pit; Design basis earthquake; Hypothetical loss of basin water accident analysis; Combustion of uranium fuel following dryout; Crane failure and cask dropped onto floor of transfer area; Spent ion exchange shipment for burial; Hydrogen deflagration in ion exchange modules and filters; Release of Chlorine; Power availability and reliability; and Ashfall.
Systems engineering and analysis
Blanchard, Benjamin S
2010-01-01
For senior-level undergraduate and first and second year graduate systems engineering and related courses. A total life-cycle approach to systems and their analysis. This practical introduction to systems engineering and analysis provides the concepts, methodologies, models, and tools needed to understand and implement a total life-cycle approach to systems and their analysis. The authors focus first on the process of bringing systems into being--beginning with the identification of a need and extending that need through requirements determination, functional analysis and allocation, design synthesis, evaluation, and validation, operation and support, phase-out, and disposal. Next, the authors discuss the improvement of systems currently in being, showing that by employing the iterative process of analysis, evaluation, feedback, and modification, most systems in existence can be improved in their affordability, effectiveness, and stakeholder satisfaction.
Ramsay, J O
1997-01-01
Scientists today collect samples of curves and other functional observations. This monograph presents many ideas and techniques for such data. Included are expressions in the functional domain of such classics as linear regression, principal components analysis, linear modelling, and canonical correlation analysis, as well as specifically functional techniques such as curve registration and principal differential analysis. Data arising in real applications are used throughout for both motivation and illustration, showing how functional approaches allow us to see new things, especially by exploiting the smoothness of the processes generating the data. The data sets exemplify the wide scope of functional data analysis; they are drwan from growth analysis, meterology, biomechanics, equine science, economics, and medicine. The book presents novel statistical technology while keeping the mathematical level widely accessible. It is designed to appeal to students, to applied data analysts, and to experienced researc...
Prone breast radiotherapy in early-stage breast cancer: a preliminary analysis
Purpose: Women with large breasts have marked dose inhomogeneity and often an inferior cosmetic outcome when treated with breast conservation compared to smaller-sized patients. We designed a prone breast board, which both minimizes breast separation and irradiated lung or heart volume. We report feasibility, cosmesis, and preliminary local control and survival for selected women with Stage 0-II breast cancer. Materials and Methods: Fifty-six patients with clinical Stage 0-II breast cancer were treated with lumpectomy and breast irradiation utilizing a prototype prone breast board. A total of 59 breasts were treated. Indications for treatment in the prone position were large or pendulous breast size (n = 57), or a history of cardiopulmonary disease (n = 2). The median bra size was 41D (range, 34D-44EE). Cosmesis was evaluated on a 1-10 (worst-to-best) scale. Results: Acute toxicity included skin erythema (80% of patients experienced Grade I or Grade II erythema), breast edema (72% of patients experienced mild edema), pruritus (20% of patients), and fatigue (20% of patients reported mild fatigue). One patient required a treatment break. The only late toxicity was related to long-term cosmesis. The mean overall cosmesis score for 53 patients was 9.37 (range, 8-10). Actuarial 3- and 5-year local control rates are 98%. Actuarial overall survival at 3 and 5 years are 98% and 94%. Conclusion: Our data indicate that treating selected women with prone breast radiotherapy is feasible and tolerated. The approach results in excellent cosmesis, and short-term outcome is comparable to traditional treatment techniques. This technique offers an innovative alternative to women who might not otherwise be considered candidates for breast conservation
Complications from arteriovenous malformation radiosurgery: multivariate analysis and risk modeling
Purpose/Objective: To assess the relationships of radiosurgery treatment parameters to the development of complications from radiosurgery for arteriovenous malformations (AVM). Methods and Materials: We evaluated follow-up imaging and clinical data in 307 AVM patients who received gamma knife radiosurgery at the University of Pittsburgh between 1987 and 1993. All patients had regular clinical or imaging follow up for a minimum of 2 years (range: 24-96 months, median = 44 months). Results: Post-radiosurgical imaging (PRI) changes developed in 30.5% of patients with regular follow-up magnetic resonance imaging, and were symptomatic in 10.7% of all patients at 7 years. PRI changes resolved within 3 years developed significantly less often (p = 0.0274) in patients with symptoms (52.8%) compared to asymptomatic patients (94.8%). The 7-year actuarial rate for developing persistent symptomatic PRI changes was 5.05%. Multivariate logistic regression modeling found that the 12 Gy volume was the only independent variable that correlated significantly with PRI changes (p < 0.0001) while symptomatic PRI changes were correlated with both 12 Gy volume (p = 0.0013) and AVM location (p 0.0066). Conclusion: Complications from AVM radiosurgery can be predicted with a statistical model relating the risks of developing symptomatic post-radiosurgical imaging changes to 12 Gy treatment volume and location
Time complexity analysis of genetic- fuzzy system for disease diagnosis
Ephzibah.E.P
2011-08-01
Full Text Available A new generation of tools and techniques are needed for finding interesting patterns in the data and discovering useful knowledge. Especially, Medical knowledge consists of a combination of structural information about known biological facts and probabilistic or actuarial information about exposures tohazards and recovery rates. Probabilistic information is especially difficult to use, as it requires constant maintenance and it usually comes in the form of study results which are not ideally suited for making individual predictions. Patterns summarizing mutual associations between class decisions and attributevalues in a pre-classified database provide insight into the significance of attributes and are also useful in classificatory knowledge. The proposed work is an efficient method to extract significant attributes from a database. Reducing the features or attributes enhances the quality of knowledge extracted and also thespeed of computation. In this paper the design of a hybrid algorithm for heart disease diagnosis usingeffective and efficient genetic algorithm and fuzzy logic is implemented. The proposed work analyses the time complexity of genetic- fuzzy system.
Strategic analysis of the company
Matoušková, Irena
2012-01-01
Strategic analysis of the company In my thesis I developed a strategic analysis of the company Pacovské strojírny a.s. I describe the various methods of internal and external strategic analysis in the theoretical part. I followed the methods used in the practical part. In an internal strategic analysis, I focused on the identification of internal resources and capabilities, the financial analysis and the chain of creating value. External strategic analysis includes PEST analysis, Porter's fiv...
Material analysis on engineering statistics
Lee, Seung Hun
2008-03-15
This book is about material analysis on engineering statistics using mini tab, which includes technical statistics and seven tools of QC, probability distribution, presumption and checking, regression analysis, tim series analysis, control chart, process capacity analysis, measurement system analysis, sampling check, experiment planning, response surface analysis, compound experiment, Taguchi method, and non parametric statistics. It is good for university and company to use because it deals with theory first and analysis using mini tab on 6 sigma BB and MBB.
Material analysis on engineering statistics
This book is about material analysis on engineering statistics using mini tab, which includes technical statistics and seven tools of QC, probability distribution, presumption and checking, regression analysis, tim series analysis, control chart, process capacity analysis, measurement system analysis, sampling check, experiment planning, response surface analysis, compound experiment, Taguchi method, and non parametric statistics. It is good for university and company to use because it deals with theory first and analysis using mini tab on 6 sigma BB and MBB.
Raket, Lars Lau
We propose a direction it the field of statistics which we will call functional object analysis. This subfields considers the analysis of functional objects defined on continuous domains. In this setting we will focus on model-based statistics, with a particularly emphasis on mixed......-effect formulations, where the observed functional signal is assumed to consist of both fixed and random functional effects. This thesis takes the initial steps toward the development of likelihood-based methodology for functional objects. We first consider analysis of functional data defined on high...
An elemental analysis, metallographic and of phases was realized in order to determine the oxidation states of Fe contained in three metallic pieces: block, plate and cylinder of unknown material. Results are presented from the elemental analysis which was carried out in the Tandem Accelerator of ININ by Proton induced X-ray emission (PIXE). The phase analysis was carried out by X-ray diffraction which allowed to know the type of alloy or alloys formed. The combined application of nuclear techniques with metallographic techniques allows the integral characterization of industrial metals. (Author)
NASA Enterprise Visual Analysis
Lopez-Tellado, Maria; DiSanto, Brenda; Humeniuk, Robert; Bard, Richard, Jr.; Little, Mia; Edwards, Robert; Ma, Tien-Chi; Hollifield, Kenneith; White, Chuck
2007-01-01
NASA Enterprise Visual Analysis (NEVA) is a computer program undergoing development as a successor to Launch Services Analysis Tool (LSAT), formerly known as Payload Carrier Analysis Tool (PCAT). NEVA facilitates analyses of proposed configurations of payloads and packing fixtures (e.g. pallets) in a space shuttle payload bay for transport to the International Space Station. NEVA reduces the need to use physical models, mockups, and full-scale ground support equipment in performing such analyses. Using NEVA, one can take account of such diverse considerations as those of weight distribution, geometry, collision avoidance, power requirements, thermal loads, and mechanical loads.
Kosmidis, Kosmas; Kalampokis, Alkiviadis; Argyrakis, Panos
2006-10-01
We use the detrended fluctuation analysis (DFA) and the Grassberger-Proccacia analysis (GP) methods in order to study language characteristics. Despite that we construct our signals using only word lengths or word frequencies, excluding in this way huge amount of information from language, the application of GP analysis indicates that linguistic signals may be considered as the manifestation of a complex system of high dimensionality, different from random signals or systems of low dimensionality such as the Earth climate. The DFA method is additionally able to distinguish a natural language signal from a computer code signal. This last result may be useful in the field of cryptography.
Kosmidis, K; Argyrakis, P; Kosmidis, Kosmas; Kalampokis, Alkiviadis; Argyrakis, Panos
2006-01-01
We use the Detrended Fluctuation Analysis (DFA) and the Grassberger-Proccacia analysis (GP) methods in order to study language characteristics. Despite that we construct our signals using only word lengths or word frequencies, excluding in this way huge amount of information from language, the application of Grassberger- Proccacia (GP) analysis indicates that linguistic signals may be considered as the manifestation of a complex system of high dimensionality, different from random signals or systems of low dimensionality such as the earth climate. The DFA method is additionally able to distinguish a natural language signal from a computer code signal. This last result may be useful in the field of cryptography.
Nielsen, Christoffer Rosenkilde; Nielson, Hanne Riis
2006-01-01
operation blinding. In this paper we study the theoretical foundations for one of the successful approaches to validating cryptographic protocols and we extend it to handle the blinding primitive. Our static analysis approach is based on Flow Logic; this gives us a clean separation between the specification...... of the analysis and its realisation in an automatic tool. We concentrate on the former in the present paper and provide the semantic foundation for our analysis of protocols using blinding - also in the presence of malicious attackers....
Integrated Analysis Capability Program
Vos, R. G.; Beste, D. L.; Greg, J.; Frisch, H. P.
1991-01-01
Integrated Analysis Capability (IAC) software system intended to provide highly effective, interactive analysis tool for integrated design of large structures. Supports needs of engineering analysis groups concerned with interdisciplinary problems. Developed to serve as software interface between computer programs from fields of structures, thermodynamics, controls, and dynamics of systems on one hand and executive software system and data base on other hand to yield highly efficient multi-disciplinary system. Special attention given to such users' requirements as handling data and online assistance with operational features and ability to add new modules of user's choice at future date. Written in FORTRAN 77.
Bayesian nonparametric data analysis
Müller, Peter; Jara, Alejandro; Hanson, Tim
2015-01-01
This book reviews nonparametric Bayesian methods and models that have proven useful in the context of data analysis. Rather than providing an encyclopedic review of probability models, the book’s structure follows a data analysis perspective. As such, the chapters are organized by traditional data analysis problems. In selecting specific nonparametric models, simpler and more traditional models are favored over specialized ones. The discussed methods are illustrated with a wealth of examples, including applications ranging from stylized examples to case studies from recent literature. The book also includes an extensive discussion of computational methods and details on their implementation. R code for many examples is included in on-line software pages.
Finite Discrete Gabor Analysis
Søndergaard, Peter Lempel
2007-01-01
Gabor analysis is a method for analyzing signals through the use of a set of basic building blocks. The building blocks consists of a certain function (the window) that is shifted in time and frequency. The Gabor expansion of a signal contains information on the behavior of the signal in certain...... basic discrete time/frequency and Gabor analysis. It is intended to be both an educational and a computational tool. The toolbox was developed as part of this Ph.D. project to provide a solid foundation for the field of computational Gabor analysis....
Factor analysis and scintigraphy
The goal of factor analysis is usually to achieve reduction of a large set of data, extracting essential features without previous hypothesis. Due to the development of computerized systems, the use of largest sampling, the possibility of sequential data acquisition and the increase of dynamic studies, the problem of data compression can be encountered now in routine. Thus, results obtained for compression of scintigraphic images were first presented. Then possibilities given by factor analysis for scan processing were discussed. At last, use of this analysis for multidimensional studies and specially dynamic studies were considered for compression and processing
In applying ALARA somebody has to determine what is reasonable. A decision has to be made. Decision Analysis is a procedure for structuring decision problems, and therefore it might be expected to be of use in the application of the ALARA principle. This paper explores the contribution that Decision Analysis may make in this context, particularly discussing the application of multi-attribute value theory. An example of using the theory on a problem of radioactive waste disposal is given, and the potential of an increased use of Decision Analysis in making the ALARA principle work, is discussed
The 'monazit' analytical program has been set up for routine work of Rare Earth Elements analysis in the monazite and xenotime minerals samples. Total relative error of the analysis is very low, less than 2.50%, and the reproducibility of counting statistic and stability of the instrument were very excellent. The precision and accuracy of the analytical program are very good with the maximum percentage relative are 5.22% and 1.61%, respectively. The mineral compositions of the 30 monazite samples have been also calculated using their chemical constituents, and the results were compared to the grain counting microscopic analysis
Numerical analysis of inflation
In this paper the mechanism of a cosmological phase transition is addressed in a new way which avoids weaknesses of previous approaches. The effects of inhomogeneities are included explicitly. A numerical analysis is presented in which for a wide class of models the Universe enters a period of new inflation. The analysis is classical and applies to models in which the scalar field responsible for driving inflation is weakly coupled to other fields. We derive heuristic arguments which determine the boundaries of the region in parameter space for which inflation is realized. The agreement with the numerical results is good. This paper complements a previous analytical analysis
Methods of Multivariate Analysis
Rencher, Alvin C
2012-01-01
Praise for the Second Edition "This book is a systematic, well-written, well-organized text on multivariate analysis packed with intuition and insight . . . There is much practical wisdom in this book that is hard to find elsewhere."-IIE Transactions Filled with new and timely content, Methods of Multivariate Analysis, Third Edition provides examples and exercises based on more than sixty real data sets from a wide variety of scientific fields. It takes a "methods" approach to the subject, placing an emphasis on how students and practitioners can employ multivariate analysis in real-life sit
Aven, Terje
2012-01-01
Foundations of Risk Analysis presents the issues core to risk analysis - understanding what risk means, expressing risk, building risk models, addressing uncertainty, and applying probability models to real problems. The author provides the readers with the knowledge and basic thinking they require to successfully manage risk and uncertainty to support decision making. This updated edition reflects recent developments on risk and uncertainty concepts, representations and treatment. New material in Foundations of Risk Analysis includes:An up to date presentation of how to understand, define and
Dunham, Ken
2014-01-01
The rapid growth and development of Android-based devices has resulted in a wealth of sensitive information on mobile devices that offer minimal malware protection. This has created an immediate demand for security professionals that understand how to best approach the subject of Android malware threats and analysis.In Android Malware and Analysis, Ken Dunham, renowned global malware expert and author, teams up with international experts to document the best tools and tactics available for analyzing Android malware. The book covers both methods of malware analysis: dynamic and static.This tact
The distributed analysis experience to date at LHCb has been positive: job success rates are high and wait times for high-priority jobs are low. LHCb users access the grid using the GANGA job-management package, while the LHCb virtual organization manages its resources using the DIRAC package. This clear division of labor has benefitted LHCb and its users greatly; it is a major reason why distributed analysis at LHCb has been so successful. The newly formed LHCb distributed analysis support team has also proved to be a success.
Iremonger, M J
2013-01-01
BASIC Stress Analysis aims to help students to become proficient at BASIC programming by actually using it in an important engineering subject. It also enables the student to use computing as a means of learning stress analysis because writing a program is analogous to teaching-it is necessary to understand the subject matter. The book begins by introducing the BASIC approach and the concept of stress analysis at first- and second-year undergraduate level. Subsequent chapters contain a summary of relevant theory, worked examples containing computer programs, and a set of problems. Topics c
This paper briefly describes WASH 1400 and the Lewis report. It attempts to define basic concepts such as risk and risk analysis, common mode failure, and rare event. Several probabilistic models which go beyond the WASH 1400 methodology are introduced; the common characteristic of these models is that they recognize explicitly that risk analysis is time dependent whereas WASH 1400 takes a per demand failure rate approach which obscures the important fact that accidents are time related. Further, the presentation of a realistic risk analysis should recognize that there are various risks which compete with one another for the lives of the individuals at risk. A way of doing this is suggested
Ash, Robert B; Lukacs, E
1972-01-01
Real Analysis and Probability provides the background in real analysis needed for the study of probability. Topics covered range from measure and integration theory to functional analysis and basic concepts of probability. The interplay between measure theory and topology is also discussed, along with conditional probability and expectation, the central limit theorem, and strong laws of large numbers with respect to martingale theory.Comprised of eight chapters, this volume begins with an overview of the basic concepts of the theory of measure and integration, followed by a presentation of var
Schuller, Björn W
2013-01-01
This book provides the reader with the knowledge necessary for comprehension of the field of Intelligent Audio Analysis. It firstly introduces standard methods and discusses the typical Intelligent Audio Analysis chain going from audio data to audio features to audio recognition. Further, an introduction to audio source separation, and enhancement and robustness are given. After the introductory parts, the book shows several applications for the three types of audio: speech, music, and general sound. Each task is shortly introduced, followed by a description of the specific data and methods applied, experiments and results, and a conclusion for this specific task. The books provides benchmark results and standardized test-beds for a broader range of audio analysis tasks. The main focus thereby lies on the parallel advancement of realism in audio analysis, as too often today’s results are overly optimistic owing to idealized testing conditions, and it serves to stimulate synergies arising from transfer of ...
Pesticide Instrumental Analysis
This workshop was the evaluation of the pesticides impact on the vegetable matrix with the purpose to determine the analysis by GC / M S. The working material were lettuce matrix, chard and a mix of green leaves and pesticides.
Canonical Information Analysis
Vestergaard, Jacob Schack; Nielsen, Allan Aasbjerg
2015-01-01
Canonical correlation analysis is an established multivariate statistical method in which correlation between linear combinations of multivariate sets of variables is maximized. In canonical information analysis introduced here, linear correlation as a measure of association between variables is...... replaced by the information theoretical, entropy based measure mutual information, which is a much more general measure of association. We make canonical information analysis feasible for large sample problems, including for example multispectral images, due to the use of a fast kernel density estimator...... for entropy estimation. Canonical information analysis is applied successfully to (1) simple simulated data to illustrate the basic idea and evaluate performance, (2) fusion of weather radar and optical geostationary satellite data in a situation with heavy precipitation, and (3) change detection in...
Henson, C Ward; Kechris, Alexander S; Odell, Edward; Finet, Catherine; Michaux, Christian; Cassels, J W S
2003-01-01
This volume comprises articles from four outstanding researchers who work at the cusp of analysis and logic. The emphasis is on active research topics; many results are presented that have not been published before and open problems are formulated.
Unsupervised Linear Discriminant Analysis
无
2006-01-01
An algorithm for unsupervised linear discriminant analysis was presented. Optimal unsupervised discriminant vectors are obtained through maximizing covariance of all samples and minimizing covariance of local k-nearest neighbor samples. The experimental results show our algorithm is effective.
Fischer, Paul; Hilbert, Astrid
2012-01-01
We introduce a platform which supplies an easy-to-handle, interactive, extendable, and fast analysis tool for time series analysis. In contrast to other software suits like Maple, Matlab, or R, which use a command-line-like interface and where the user has to memorize/look-up the appropriate...... commands, our application is select-and-click-driven. It allows to derive many different sequences of deviations for a given time series and to visualize them in different ways in order to judge their expressive power and to reuse the procedure found. For many transformations or model-ts, the user may...... choose between manual and automated parameter selection. The user can dene new transformations and add them to the system. The application contains efficient implementations of advanced and recent techniques for time series analysis including techniques related to extreme value analysis and filtering...
Principles of Fourier analysis
Howell, Kenneth B
2001-01-01
Fourier analysis is one of the most useful and widely employed sets of tools for the engineer, the scientist, and the applied mathematician. As such, students and practitioners in these disciplines need a practical and mathematically solid introduction to its principles. They need straightforward verifications of its results and formulas, and they need clear indications of the limitations of those results and formulas.Principles of Fourier Analysis furnishes all this and more. It provides a comprehensive overview of the mathematical theory of Fourier analysis, including the development of Fourier series, "classical" Fourier transforms, generalized Fourier transforms and analysis, and the discrete theory. Much of the author''s development is strikingly different from typical presentations. His approach to defining the classical Fourier transform results in a much cleaner, more coherent theory that leads naturally to a starting point for the generalized theory. He also introduces a new generalized theory based ...
Brackney, Larry; Parker, Andrew; Long, Nicholas; Metzger, Ian; Dean, Jesse; Lisell, Lars
2016-04-12
A building energy analysis system includes a building component library configured to store a plurality of building components, a modeling tool configured to access the building component library and create a building model of a building under analysis using building spatial data and using selected building components of the plurality of building components stored in the building component library, a building analysis engine configured to operate the building model and generate a baseline energy model of the building under analysis and further configured to apply one or more energy conservation measures to the baseline energy model in order to generate one or more corresponding optimized energy models, and a recommendation tool configured to assess the one or more optimized energy models against the baseline energy model and generate recommendations for substitute building components or modifications.
Paciesas, William S.
1993-01-01
Miscellaneous tasks related to the operation of, and analysis of data from, the Burst and Transient Experiment (BATSE) on the Compton Gamma Ray Observatory (CGRO) were performed. The results are summarized and relevant references are included.
Main: Nucleotide Analysis [KOME
Full Text Available Nucleotide Analysis GenBank blastx search ... result Result of blastx search ... against GenBank amino a ... cid sequence kome_genbank_blastx_search _result.zip kome_genbank_blastx_search _result ...
Main: Nucleotide Analysis [KOME
Full Text Available Nucleotide Analysis GenBank blastn search ... result Result of blastn search ... against GenBank nucleot ... ide sequence kome_genbank_blastn_search _result.zip kome_genbank_blastn_search _result ...
Quantitative investment analysis
DeFusco, Richard
2007-01-01
In the "Second Edition" of "Quantitative Investment Analysis," financial experts Richard DeFusco, Dennis McLeavey, Jerald Pinto, and David Runkle outline the tools and techniques needed to understand and apply quantitative methods to today's investment process.
Arent, D.; Benioff, R.; Mosey, G.; Bird, L.; Brown, J.; Brown, E.; Vimmerstedt, L.; Aabakken, J.; Parks, K.; Lapsa, M.; Davis, S.; Olszewski, M.; Cox, D.; McElhaney, K.; Hadley, S.; Hostick, D.; Nicholls, A.; McDonald, S.; Holloman, B.
2006-10-01
This paper presents the results of energy market analysis sponsored by the Department of Energy's (DOE) Weatherization and International Program (WIP) within the Office of Energy Efficiency and Renewable Energy (EERE). The analysis was conducted by a team of DOE laboratory experts from the National Renewable Energy Laboratory (NREL), Oak Ridge National Laboratory (ORNL), and Pacific Northwest National Laboratory (PNNL), with additional input from Lawrence Berkeley National Laboratory (LBNL). The analysis was structured to identify those markets and niches where government can create the biggest impact by informing management decisions in the private and public sectors. The analysis identifies those markets and niches where opportunities exist for increasing energy efficiency and renewable energy use.
Gasińksi, Leszek
2014-01-01
Exercises in Analysis will be published in two volumes. This first volume covers problems in five core topics of mathematical analysis: metric spaces; topological spaces; measure, integration, and Martingales; measure and topology; and functional analysis. Each of five topics correspond to a different chapter with inclusion of the basic theory and accompanying main definitions and results, followed by suitable comments and remarks for better understanding of the material. At least 170 exercises/problems are presented for each topic, with solutions available at the end of each chapter. The entire collection of exercises offers a balanced and useful picture for the application surrounding each topic. This nearly encyclopedic coverage of exercises in mathematical analysis is the first of its kind and is accessible to a wide readership. Graduate students will find the collection of problems valuable in preparation for their preliminary or qualifying exams as well as for testing their deeper understanding of th...
Denker, A; Rauschenberg, J; Röhrich, J; Strub, E
2006-01-01
Materials analysis with ion beams exploits the interaction of ions with the electrons and nuclei in the sample. Among the vast variety of possible analytical techniques available with ion beams we will restrain to ion beam analysis with ion beams in the energy range from one to several MeV per mass unit. It is possible to use either the back-scattered projectiles (RBS – Rutherford Back Scattering) or the recoiled atoms itself (ERDA – Elastic Recoil Detection Analysis) from the elastic scattering processes. These techniques allow the simultaneous and absolute determination of stoichiometry and depth profiles of the detected elements. The interaction of the ions with the electrons in the sample produces holes in the inner electronic shells of the sample atoms, which recombine and emit X-rays characteristic for the element in question. Particle Induced X-ray Emission (PIXE) has shown to be a fast technique for the analysis of elements with an atomic number above 11.
Crabb, J W; West, K A; Dodson, W S; Hulmes, J D
2001-05-01
Amino acid analysis (AAA) is one of the best methods to quantify peptides and proteins. Two general approaches to quantitative AAA exist, namely, classical postcolumn derivatization following ion-exchange chromatography and precolumn derivatization followed by reversed-phase HPLC (RP-HPLC). Excellent instrumentation and several specific methodologies are available for both approaches, and both have advantages and disadvantages. This unit focuses on picomole-level AAA of peptides and proteins using the most popular precolumn-derivatization method, namely, phenylthiocarbamyl amino acid analysis (PTC-AAA). It is directed primarily toward those interested in establishing the technology with a modest budget. PTC derivatization and analysis conditions are described, and support and alternate protocols describe additional techniques necessary or useful for most any AAA method--e.g., sample preparation, hydrolysis, instrument calibration, data interpretation, and analysis of difficult or unusual residues such as cysteine, tryptophan, phosphoamino acids, and hydroxyproline. PMID:18429107
Main: Nucleotide Analysis [KOME
Full Text Available Nucleotide Analysis PLACE search result Result of signal search against PLACE : cis-acting regul ... atory DNA elements Database ... kome_place_search_result.zip kome_place_search_res ...
Longitudinal categorical data analysis
Sutradhar, Brajendra C
2014-01-01
This is the first book in longitudinal categorical data analysis with parametric correlation models developed based on dynamic relationships among repeated categorical responses. This book is a natural generalization of the longitudinal binary data analysis to the multinomial data setup with more than two categories. Thus, unlike the existing books on cross-sectional categorical data analysis using log linear models, this book uses multinomial probability models both in cross-sectional and longitudinal setups. A theoretical foundation is provided for the analysis of univariate multinomial responses, by developing models systematically for the cases with no covariates as well as categorical covariates, both in cross-sectional and longitudinal setups. In the longitudinal setup, both stationary and non-stationary covariates are considered. These models have also been extended to the bivariate multinomial setup along with suitable covariates. For the inferences, the book uses the generalized quasi-likelihood as w...
13. seminar 'Activation analysis'
Collection of the abstracts of contributions to the seminar covering broad ranges of application of activation analysis and improvements of systems and process steps. Most of them have been prepared separately for the energy data bases. (RB)
Multidimensional nonlinear descriptive analysis
Nishisato, Shizuhiko
2006-01-01
Quantification of categorical, or non-numerical, data is a problem that scientists face across a wide range of disciplines. Exploring data analysis in various areas of research, such as the social sciences and biology, Multidimensional Nonlinear Descriptive Analysis presents methods for analyzing categorical data that are not necessarily sampled randomly from a normal population and often involve nonlinear relations. This reference not only provides an overview of multidimensional nonlinear descriptive analysis (MUNDA) of discrete data, it also offers new results in a variety of fields. The first part of the book covers conceptual and technical preliminaries needed to understand the data analysis in subsequent chapters. The next two parts contain applications of MUNDA to diverse data types, with each chapter devoted to one type of categorical data, a brief historical comment, and basic skills peculiar to the data types. The final part examines several problems and then concludes with suggestions for futu...
Water Quality Analysis Simulation
U.S. Environmental Protection Agency — The Water Quality analysis simulation Program, an enhancement of the original WASP. This model helps users interpret and predict water quality responses to natural...
... may experience difficulties. Several factors can affect the sperm count or other semen analysis values, including use of alcohol, tobacco, ... the News Article Index About This Site Send Us Your Comments ...
Federal Laboratory Consortium — Provides engineering design of aircraft components, subsystems and installations using Pro/E, Anvil 1000, CADKEY 97, AutoCAD 13. Engineering analysis tools include...
Piping stress analysis on Primary Sampling System, Reactor Cooling System, and Feedwater System for AP600 have been performed. Piping stress analysis is one of the requirements in the design of piping system. Piping stress is occurred due to static and dynamic loads during service. Analysis was carried out. Using PS+CAEPIPE software based on the individual and combination loads with assumption that failure could be happened during normal, upset, emergency and faulted condition as describe in ASME III/ANSI B31.1. With performing the piping stress analysis, the layout (proper pipe routing) of the piping system can be design with the requirements of piping stress and pipe supports in mind I.e sufficient flexibility for thermal expansion, etc to commensurate with the i tended service such as temperatures, pressure, seismic and anticipated loading
Main: Nucleotide Analysis [KOME
Full Text Available Nucleotide Analysis Japonica genome blast search result Result of blastn search against japonica genome... sequence kome_japonica_genome_blast_search_result.zip kome_japonica_genome_blast_search_result ...
Main: Nucleotide Analysis [KOME
Full Text Available Nucleotide Analysis Indica genome blast search result Result of blastn search against Indica genome... sequence (top hit only) kome_indica_genome_blast_search_result.zip kome_indica_genome_blast_search_result ...
US Fish and Wildlife Service, Department of the Interior — This document is an analysis and summary of progress toward achieving the interim management objectives for the Russian River during the 1979 season. Additionally,...
NOAA's Inundation Analysis Tool
National Oceanic and Atmospheric Administration, Department of Commerce — Coastal storms and other meteorological phenomenon can have a significant impact on how high water levels rise and how often. The inundation analysis program is...
Barth, Howard G.; Sun, Shao-Tang
1989-01-01
Presents a review of research focusing on scattering, elution techniques, electrozone sensing, filtration, centrifugation, comparison of techniques, data analysis, and particle size standards. The review covers the period 1986-1988. (MVL)
Systems analysis-independent analysis and verification
Badin, J.S.; DiPietro, J.P. [Energetics, Inc., Columbia, MD (United States)
1995-09-01
The DOE Hydrogen Program is supporting research, development, and demonstration activities to overcome the barriers to the integration of hydrogen into the Nation`s energy infrastructure. Much work is required to gain acceptance of hydrogen energy system concepts and to develop them for implementation. A systems analysis database has been created that includes a formal documentation of technology characterization profiles and cost and performance information. Through a systematic and quantitative approach, system developers can understand and address important issues and thereby assure effective and timely commercial implementation. This project builds upon and expands the previously developed and tested pathway model and provides the basis for a consistent and objective analysis of all hydrogen energy concepts considered by the DOE Hydrogen Program Manager. This project can greatly accelerate the development of a system by minimizing the risk of costly design evolutions, and by stimulating discussions, feedback, and coordination of key players and allows them to assess the analysis, evaluate the trade-offs, and to address any emerging problem areas. Specific analytical studies will result in the validation of the competitive feasibility of the proposed system and identify system development needs. Systems that are investigated include hydrogen bromine electrolysis, municipal solid waste gasification, electro-farming (biomass gasifier and PEM fuel cell), wind/hydrogen hybrid system for remote sites, home electrolysis and alternate infrastructure options, renewable-based electrolysis to fuel PEM fuel cell vehicle fleet, and geothermal energy used to produce hydrogen. These systems are compared to conventional and benchmark technologies. Interim results and findings are presented. Independent analyses emphasize quality, integrity, objectivity, a long-term perspective, corporate memory, and the merging of technical, economic, operational, and programmatic expertise.
Software reliability analysis in probabilistic risk analysis
Probabilistic Risk Analysis (PRA) is a tool which can reveal shortcomings of the NPP design in general. PRA analysts have not had sufficient guiding principles in modelling particular digital components malfunctions. Digital I and C systems are mostly analysed simply and the software reliability estimates are engineering judgments often lacking a proper justification. The OECD/NEA Working Group RISK's task DIGREL develops a taxonomy of failure modes of digital I and C systems. The EU FP7 project HARMONICS develops software reliability estimation method based on an analytic approach and Bayesian belief network. (author)
Gait Analysis by Multi Video Sequence Analysis
Jensen, Karsten; Juhl, Jens
2009-01-01
The project presented in this article aims to develop software so that close-range photogrammetry with sufficient accuracy can be used to point out the most frequent foot mal positions and monitor the effect of the traditional treatment. The project is carried out as a cooperation between the Ort...... Sequence Analysis (MVSA). Results show that the developed MVSA system, in the following called Fodex, can measure the navicula height with a precision of 0.5-0.8 mm. The calcaneus angle can be measured with a precision of 0.8-1.5 degrees....
Hartmanová, Dominika
2013-01-01
Bachelor Thesis Analysis of the marketing mix describes a marketing mix of company Lego Tradings, s. r. o. The theoretical part includes specification of basic concepts, such as marketing, marketing mix, tools of marketing mix, product, price, place and promotion. The second part is devoted to custom solutions. The introducion of the Lego company comes first. There are also analysis of the tools of marketing mix. In this part the results are described for a marketing research, namely a quest...
Oktavianto, Digit
2013-01-01
This book is a step-by-step, practical tutorial for analyzing and detecting malware and performing digital investigations. This book features clear and concise guidance in an easily accessible format.Cuckoo Malware Analysis is great for anyone who wants to analyze malware through programming, networking, disassembling, forensics, and virtualization. Whether you are new to malware analysis or have some experience, this book will help you get started with Cuckoo Sandbox so you can start analysing malware effectively and efficiently.
Economic Analysis of Constitutions
Roger B. Myerson
2000-01-01
This paper is a preliminary draft of an article to appear in Chicago Law Review (2000), as part of a symposium reviewing two new books on economic analysis of constitutions: Dennis Mueller's Constitutional Democracy and Robert Cooter's Strategic Constitution. Some of the basic questions of constitutional analysis are introduced, and the importance of work in this area is shown as one of the major new developments in social theory. The methods of economic theory are then shown to be particular...
MEAD retrospective analysis report
Hasager, Charlotte Bay; CARSTENSEN J.; Frohn, L. M.; Gustafson, B.; Brandt, J.; Conley, D.; Geernaert, G.; Henriksen, P.; C. A. Skjøth; Johnsson, M.
2003-01-01
The retrospective analysis investigates links between atmospheric nitrogen deposition and algal bloom development in the Kattegat Sea from April to September 1989-1999. The analysis is based on atmospheric deposition model results from the ACDEP model,hydrodynamic deep-water flux results, phytoplankton abundance observations from Danish and Swedish marine monitoring stations and optical satellite data. Approximately 70 % of the atmospheric deposition consists of wet depostion of highly episod...
Boggs, Paul T.; Althsuler, Alan (Exagrid Engineering); Larzelere, Alex R. (Exagrid Engineering); Walsh, Edward J.; Clay, Ruuobert L.; Hardwick, Michael F. (Sandia National Laboratories, Livermore, CA)
2005-08-01
The Design-through-Analysis Realization Team (DART) is chartered with reducing the time Sandia analysts require to complete the engineering analysis process. The DART system analysis team studied the engineering analysis processes employed by analysts in Centers 9100 and 8700 at Sandia to identify opportunities for reducing overall design-through-analysis process time. The team created and implemented a rigorous analysis methodology based on a generic process flow model parameterized by information obtained from analysts. They also collected data from analysis department managers to quantify the problem type and complexity distribution throughout Sandia's analyst community. They then used this information to develop a community model, which enables a simple characterization of processes that span the analyst community. The results indicate that equal opportunity for reducing analysis process time is available both by reducing the ''once-through'' time required to complete a process step and by reducing the probability of backward iteration. In addition, reducing the rework fraction (i.e., improving the engineering efficiency of subsequent iterations) offers approximately 40% to 80% of the benefit of reducing the ''once-through'' time or iteration probability, depending upon the process step being considered. Further, the results indicate that geometry manipulation and meshing is the largest portion of an analyst's effort, especially for structural problems, and offers significant opportunity for overall time reduction. Iteration loops initiated late in the process are more costly than others because they increase ''inner loop'' iterations. Identifying and correcting problems as early as possible in the process offers significant opportunity for time savings.
Submarine hydraulic control analysis
Bower, Michael J.
1980-01-01
Approved for public release; distribution unlimited A mathematical model was developed to include line effects in the submarine hydraulic system dynamic performance analysis. The project was undertaken in an effort to demonstrate the necessity of coupling the entire hydraulic power network for an accurate analysis of any of the subsystems rather than the current practice of treating a component loop as an isolated system. It was intended that the line model could be co...
Vávrová, Eva
2014-01-01
This thesis deals with the analysis of EEG during various sleep stages, which is done by calculating the selected parameters from the time and frequency domain. These parameters are calculated from individual segments of EEG signals that correspond with various sleep stages. Based on the analysis it decides which EEG parameters are appropriate for the automatic detection of the phases and which method is more suitable for evaluation of data in hypnogram. The programme MATLAB was used for the ...
Speed, T. P.
2003-01-01
This talk will review a little over a decade's research on applying certain stochastic models to biological sequence analysis. The models themselves have a longer history, going back over 30 years, although many novel variants have arisen since that time. The function of the models in biological sequence analysis is to summarize the information concerning what is known as a motif or a domain in bioinformatics, and to provide a tool for discovering instances of that motif or domain in a separa...
Mateev, Nikolay; Menon, Vijay; Pingali, Keshav
2000-01-01
Restructuring compilers use dependence analysis to prove that the meaning of a program is not changed by a transformation. A well-known limitation of dependence analysis is that it examines only the memory locations read and written by a statement, and does not assume any particular interpretation for the operations in that statement. Exploiting the semantics of these operations enables a wider set of transformations to be used, and is critical for optimizing important codes such as LU factor...
Bass, Roger
2010-01-01
Zen's challenge for behavior analysis is to explain a repertoire that renders analysis itself meaningless—a result following not from scientific or philosophical arguments but rather from a unique verbal history generated by Zen's methods. Untying Zen's verbal knots suggests how meditation's and koans' effects on verbal behavior contribute to Enlightenment and Samādhi. The concept of stimulus singularity is introduced to account for why, within Zen's frame of reference, its methods can be stu...
During normal data taking CMS expects to support potentially as many as 2000 analysis users. Since the beginning of 2008 there have been more than 800 individuals who submitted a remote analysis job to the CMS computing infrastructure. The bulk of these users will be supported at the over 40 CMS Tier-2 centres. Supporting a globally distributed community of users on a globally distributed set of computing clusters is a task that requires reconsidering the normal methods of user support for Analysis Operations. In 2008 CMS formed an Analysis Support Task Force in preparation for large-scale physics analysis activities. The charge of the task force was to evaluate the available support tools, the user support techniques, and the direct feedback of users with the goal of improving the success rate and user experience when utilizing the distributed computing environment. The task force determined the tools needed to assess and reduce the number of non-zero exit code applications submitted through the grid interfaces and worked with the CMS experiment dashboard developers to obtain the necessary information to quickly and proactively identify issues with user jobs and data sets hosted at various sites. Results of the analysis group surveys were compiled. Reference platforms for testing and debugging problems were established in various geographic regions. The task force also assessed the resources needed to make the transition to a permanent Analysis Operations task. In this presentation the results of the task force will be discussed as well as the CMS Analysis Operations plans for the start of data taking.
Provenance as Dependency Analysis
Cheney, James; Ahmed, Amal; Acar, Umut,
2007-01-01
Provenance is information recording the source, derivation, or history of some information. Provenance tracking has been studied in a variety of settings; however, although many design points have been explored, the mathematical or semantic foundations of data provenance have received comparatively little attention. In this paper, we argue that dependency analysis techniques familiar from program analysis and program slicing provide a formal foundation for forms of provenance that are intende...
Bayesian Group Factor Analysis
Virtanen, Seppo; Klami, Arto; Khan, Suleiman A; Kaski, Samuel
2011-01-01
We introduce a factor analysis model that summarizes the dependencies between observed variable groups, instead of dependencies between individual variables as standard factor analysis does. A group may correspond to one view of the same set of objects, one of many data sets tied by co-occurrence, or a set of alternative variables collected from statistics tables to measure one property of interest. We show that by assuming group-wise sparse factors, active in a subset of the sets, the variat...
Klami, Arto; Virtanen, Seppo; Leppäaho, Eemeli; Kaski, Samuel
2014-01-01
Factor analysis provides linear factors that describe relationships between individual variables of a data set. We extend this classical formulation into linear factors that describe relationships between groups of variables, where each group represents either a set of related variables or a data set. The model also naturally extends canonical correlation analysis to more than two sets, in a way that is more flexible than previous extensions. Our solution is formulated as variational inferenc...
Analysis of irradiated materials
Papers presented at the UKAEA Conference on Materials Analysis by Physical Techniques (1987) covered a wide range of techniques as applied to the analysis of irradiated materials. These varied from reactor component materials, materials associated with the Authority's radwaste disposal programme, fission products and products associated with the decommissioning of nuclear reactors. An invited paper giving a very comprehensive review of Laser Ablation Microprobe Mass Spectroscopy (LAMMS) was included in the programme. (author)
Oden, J Tinsley
2010-01-01
The textbook is designed to drive a crash course for beginning graduate students majoring in something besides mathematics, introducing mathematical foundations that lead to classical results in functional analysis. More specifically, Oden and Demkowicz want to prepare students to learn the variational theory of partial differential equations, distributions, and Sobolev spaces and numerical analysis with an emphasis on finite element methods. The 1996 first edition has been used in a rather intensive two-semester course. -Book News, June 2010
Software for Schenkerian Analysis
Marsden, Alan
2011-01-01
Software developed to automate the process of Schen-kerian analysis is described. The current state of the art is that moderately good analyses of small extracts can be generated, but more information is required about the criteria by which analysts make decisions among alternative interpretations in the course of analysis. The software described here allows the procedure of reduction to be examined while in process, allowing decision points, and potentially criteria, to become clear.
Ho, Nancy; Sommers, Marilyn
2013-01-01
Anhedonia presents itself in a myriad of disease processes. To further develop our understanding of anhedonia and effective ways to manage it, the concept requires clear boundaries. This paper critically examined the current scientific literature and conducted a concept analysis of anhedonia to provide a more accurate and lucid understanding the concept. As part of the concept analysis, this paper also provides model, borderline, related, and contrary examples of anhedonia.
The objective of SCK-CEN's programme on reactor safety is to develop expertise in probabilistic and deterministic reactor safety analysis. The research programme consists of four main activities, in particular the development of software for reliability analysis of large systems and participation in the international PHEBUS-FP programme for severe accidents, the development of an expert system for the aid to diagnosis; the development and application of a probabilistic reactor dynamics method. Main achievements in 1999 are reported
Griffel, DH
2002-01-01
A stimulating introductory text, this volume examines many important applications of functional analysis to mechanics, fluid mechanics, diffusive growth, and approximation. Detailed enough to impart a thorough understanding, the text is also sufficiently straightforward for those unfamiliar with abstract analysis. Its four-part treatment begins with distribution theory and discussions of Green's functions. Essentially independent of the preceding material, the second and third parts deal with Banach spaces, Hilbert space, spectral theory, and variational techniques. The final part outlines the
2011-04-07
... on the actuarial and economic assumptions and methods by which Trustees might more accurately measure... estimation involving economics and actuarial science. Panelists are not restricted, however, in the...
77 FR 21775 - Risk Adjustment Meeting-May 7, 2012 and May 8, 2012
2012-04-11
... following topics: The risk adjustment model, calculation of plan average actuarial risk, calculation of... risk adjustment model, calculation of plan average actuarial risk, calculation of payments and...
76 FR 58514 - Medicare Program; Meeting of the Technical Advisory Panel on Medicare Trustee Reports
2011-09-21
... on the actuarial and economic assumptions and methods by which Trustees might more accurately project... estimation involving economics and actuarial science. Panelists are not restricted, however, in the...
2012-06-05
..., corporate trust, actuarial counseling, investment counseling, investment management, and accounting; and... counseling; (4) actuarial counseling; and (5) the general public. The Department of Labor is committed...
75 FR 62401 - Agency Information Collection Activities: Proposed Collection; Comment Request
2010-10-08
..., Medicare Advantage organizations (MAO) and Prescription Drug Plans are required to submit an actuarial... Bid Pricing Tool (BPT) software to develop their actuarial pricing bid. The information provided...
Khedker, Uday P; Rawat, Prashant Singh
2011-01-01
Flow- and context-sensitive pointer analysis is generally considered too expensive for large programs; most tools relax one or both of the requirements for scalability. We formulate a flow- and context-sensitive points-to analysis that is lazy in the following sense: points-to information is computed only for live pointers and its propagation is sparse (restricted to live ranges of respective pointers). Further, our analysis (a) uses strong liveness, effectively including dead code elimination; (b) afterwards calculates must-points-to information from may-points-to information instead of using a mutual fixed-point; and (c) uses value-based termination of call strings during interprocedural analysis (which reduces the number of call strings significantly). A naive implementation of our analysis within GCC-4.6.0 gave analysis time and size of points-to measurements for SPEC2006. Using liveness reduced the amount of points-to information by an order of magnitude with no loss of precision. For all programs under ...
Integrated genetic analysis microsystems
With the completion of the Human Genome Project and the ongoing DNA sequencing of the genomes of other animals, bacteria, plants and others, a wealth of new information about the genetic composition of organisms has become available. However, as the demand for sequence information grows, so does the workload required both to generate this sequence and to use it for targeted genetic analysis. Microfabricated genetic analysis systems are well poised to assist in the collection and use of these data through increased analysis speed, lower analysis cost and higher parallelism leading to increased assay throughput. In addition, such integrated microsystems may point the way to targeted genetic experiments on single cells and in other areas that are otherwise very difficult. Concomitant with these advantages, such systems, when fully integrated, should be capable of forming portable systems for high-speed in situ analyses, enabling a new standard in disciplines such as clinical chemistry, forensics, biowarfare detection and epidemiology. This review will discuss the various technologies available for genetic analysis on the microscale, and efforts to integrate them to form fully functional robust analysis devices. (topical review)
A review of research and development on NAA as well as examples of applications of this method are presented, taken from work carried out over the last 21 years at the Radioanalytical Laboratory of the Department of Chemistry in the Greek Nuclear Research Center ''Demokritos''. Improved and faster radiochemical NAA methods have been developed for the determination of Au, Ni, Cl, As, Cu, U, Cr, Eu, Hg and Mo in several materials, for the simultaneous determination of Br and I; Mg, Sr and Ni; As and Cu; As, Sb and Hg; Mn, Sr and Ba; Cd and Zn; Se and As; Mo and Cr in biological materials. Instrumental NAA methods have also been developed for the determination of Ag, Cl and Na in lake waters, Al, Ca, Mg and V in wines, 7 trace elements in biological materials, 17 trace elements in sediments and 20 minor and trace elements in ceramics. A comprehensive computer program for routine activation analysis using Ge(Li) detectors have been worked out. A rather extended charged-particle activation analysis program is carried out for the last 10 years, including particle induced X-ray emission (PIXE) analysis, particle induced prompt gamma-ray emission analysis (PIGE), other nuclear reactions and proton activation analysis. A special neutron activation method, the delayed fission neutron counting method is used for the analysis of fissionable elements, as U, Th, Pu, in samples of the whole nuclear fuel cycle including geological, enriched and nuclear safeguards samples
Dewhurst, A.; Legger, F.
2015-12-01
The ATLAS experiment accumulated more than 140 PB of data during the first run of the Large Hadron Collider (LHC) at CERN. The analysis of such an amount of data is a challenging task for the distributed physics community. The Distributed Analysis (DA) system of the ATLAS experiment is an established and stable component of the ATLAS distributed computing operations. About half a million user jobs are running daily on DA resources, submitted by more than 1500 ATLAS physicists. The reliability of the DA system during the first run of the LHC and the following shutdown period has been high thanks to the continuous automatic validation of the distributed analysis sites and the user support provided by a dedicated team of expert shifters. During the LHC shutdown, the ATLAS computing model has undergone several changes to improve the analysis workflows, including the re-design of the production system, a new analysis data format and event model, and the development of common reduction and analysis frameworks. We report on the impact such changes have on the DA infrastructure, describe the new DA components, and include recent performance measurements.
Legger, Federica; The ATLAS collaboration
2015-01-01
The ATLAS experiment accumulated more than 140 PB of data during the first run of the Large Hadron Collider (LHC) at CERN. The analysis of such an amount of data for the distributed physics community is a challenging task. The Distributed Analysis (DA) system of the ATLAS experiment is an established and stable component of the ATLAS distributed computing operations. About half a million user jobs are daily running on DA resources, submitted by more than 1500 ATLAS physicists. The reliability of the DA system during the first run of the LHC and the following shutdown period has been high thanks to the continuous automatic validation of the distributed analysis sites and the user support provided by a dedicated team of expert shifters. During the LHC shutdown, the ATLAS computing model has undergone several changes to improve the analysis workflows, including the re-design of the production system, a new analysis data format and event model, and the development of common reduction and analysis frameworks. We r...
Activation analysis in forensic studies
Application of neutron activation analysis in forensics are grouped into 3 categories: firearms-discharge applications, elemental analysis of other nonbiological evidence materials (paint, other), and elemental analysis of biological evidence materials (multielemental analysis of hair, analysis of hair for As and Hg). 18 refs
Adjuvant postoperative radiation therapy for resectable rectal cancer
Following potentially curative surgery for resectable adenocarcinoma of the rectum, the incidence of local failure is 15% to 35% in stages T3N0 and T1N1-2 and 45% to 65% in stages T4N0, T3N1-2, and T4N1-2. In order to determine the impact of pelvic radiation therapy±chemotherapy on local failure and survival, we present a prospective analysis of our results of 25 patients treated with this approach. The median follow-up was 30 months (range: 10 to 48 months). For the total patients group the 3-year actuarial survival was 74%. In order to more accurately analyze the patterns of failure, actuarial calculations were performed. The actuarial incidence of local failure as a component of failure was 17%. For patients with node positive disesse (T1-4N1-2), the overall survival was 80%, and the actuarial incidence of local failure as a component of failure was 15%. Complications were acceptable and the incidence of small bowel obstruction requiring surgery was 8%. (author)
Effectiveness of brachytherapy in treating carcinoma of the vulva
Purpose: Radical radiotherapeutic management of vulvar cancer often incorporates brachytherapy as a portion of the treatment regimen. However, few studies using this modality alone to manage vulvar cancer have been published. Methods and Materials: Thirty four patients were treated with iridium-192 (192Ir) brachytherapy for vulvar cancer between 1975 and 1993 at Centre Alexis Vautrin. Twenty-one patients were treated at first presentation when surgery was contraindicated or declined. Of these patients, 12 had International Federation of Gynecology and Obstetrics Classification Stage III or IV disease, 8 were Stage II, 1 was Stage I, and 1 was Stage 0. Thirteen patients were treated for recurrent disease. Paris system rules for implantation and dose prescription were followed. The median reference dose was 60 Gy (range 53 to 88 Gy). At the time of analysis, 10 of 34 patients were alive. Median follow-up in these 10 patients was 31 months (range: 21 months to 107 months). Fourteen of the 24 deaths were from causes other than vulvar cancer. Results: Kaplan-Meier actuarial 5-year local control was 47% (95% confidence interval (CI) = 23 to 73%) and 5-year actuarial loco-regional control was 45% (95% CI = 21 to 70%). Kaplan-Meier actuarial 5-year disease-specific survival was 56% (95% CI = 33 to 76%) and actuarial 5-year survival was 29% (95% CI = 15 to 49%). Median time to death was 14 months. Subset analysis revealed a higher actuarial 5-year local control in patients treated at first presentation than those treated for recurrence (80 vs. 19%, log rank, p = 0.04). Similarly, actuarial 5-year loco-regional control was higher in patients treated at first presentation (80 vs. 16%, log rank, p 0.01). The two groups did not differ significantly in disease-specific or overall survival. The actuarial 5-year disease specific survival of 56% is somewhat less than the expected 5-year disease-specific survival after surgery in a group having a similar proportion of early stage
Failure Analysis for Improved Reliability
Sood, Bhanu
2016-01-01
Outline: Section 1 - What is reliability and root cause? Section 2 - Overview of failure mechanisms. Section 3 - Failure analysis techniques (1. Non destructive analysis techniques, 2. Destructive Analysis, 3. Materials Characterization). Section 4 - Summary and Closure
Renal calculi: genesis and analysis
In this paper, genesis, composition and analysis of urolithiasis is discussed. Methods of medical examination are considered, e.g. quantitative analysis, infrared spectrometry, and X-ray diffraction analysis. (Auth.)
Software engineering with analysis patterns
Geyer-Schulz, Andreas; Hahsler, Michael
2001-01-01
The purpose of this article is twofold, first to promote the use of patterns in the analysis phase of the software life-cycle by proposing an outline template for analysis patterns that strongly supports the whole analysis process from the requirements analysis to the analysis model and further on to its transformation into a flexible design. Second we present, as an example, a family of analysis patterns that deal with a series of pressing problems in cooperative work, collaborative informat...