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Sample records for activity graphical profiles

  1. Quantitative genetic activity graphical profiles for use in chemical evaluation

    Waters, M.D. [Environmental Protection Agency, Washington, DC (United States); Stack, H.F.; Garrett, N.E.; Jackson, M.A. [Environmental Health Research and Testing, Inc., Research Triangle Park, NC (United States)

    1990-12-31

    A graphic approach, terms a Genetic Activity Profile (GAP), was developed to display a matrix of data on the genetic and related effects of selected chemical agents. The profiles provide a visual overview of the quantitative (doses) and qualitative (test results) data for each chemical. Either the lowest effective dose or highest ineffective dose is recorded for each agent and bioassay. Up to 200 different test systems are represented across the GAP. Bioassay systems are organized according to the phylogeny of the test organisms and the end points of genetic activity. The methodology for producing and evaluating genetic activity profile was developed in collaboration with the International Agency for Research on Cancer (IARC). Data on individual chemicals were compiles by IARC and by the US Environmental Protection Agency (EPA). Data are available on 343 compounds selected from volumes 1-53 of the IARC Monographs and on 115 compounds identified as Superfund Priority Substances. Software to display the GAPs on an IBM-compatible personal computer is available from the authors. Structurally similar compounds frequently display qualitatively and quantitatively similar profiles of genetic activity. Through examination of the patterns of GAPs of pairs and groups of chemicals, it is possible to make more informed decisions regarding the selection of test batteries to be used in evaluation of chemical analogs. GAPs provided useful data for development of weight-of-evidence hazard ranking schemes. Also, some knowledge of the potential genetic activity of complex environmental mixtures may be gained from an assessment of the genetic activity profiles of component chemicals. The fundamental techniques and computer programs devised for the GAP database may be used to develop similar databases in other disciplines. 36 refs., 2 figs.

  2. Graphical method for profiling hob mill that generate cycloid worms

    Teodor, V.; Berbinschi, S.; Baroiu, N.; Oancea, N.

    2015-11-01

    The hob mill for generating ordered curls of cycloid surface with non involute profiles may be profiled based on the fundamental theorems of surface enveloping - Olivier - as surface reciprocally enveloping with point like contact. In this paper, is proposed a methodology based on a complementary theorem of the surface enveloping in a graphical expression developed in a graphical design environment - CATIA. The graphical method presented in this paper is developed in two stages: determining of the rack gear model based on the solid model of the surface to be generated, using an original algorithm, following this, based on 3D modelling is determined the solid model of the primary peripheral surface of the hob mill. An application for a cycloid worm is presented - a central screw of helical pumps. In order to prove the quality of method, the analytical and graphical solutions are comparatively presented.

  3. Cereal Box Design: An Interdisciplinary Graphics Activity

    Fitzgerald, Mike; Tsosie, Teri

    2012-01-01

    The cereal box design activity is intriguing both for its simplicity and the resourcefulness that it can generate in young people. Also, it lends itself to a variety of curriculums. It covers both consumerism and Design for the Environment (DfE) concepts broadly and in depth. The activity introduces a wide range of topics. They include graphic…

  4. Graphics processing unit-assisted density profile calculations in the KSTAR reflectometer

    Seo, Seong-Heon; Oh, Dong Keun

    2014-11-01

    Wavelet transform (WT) is widely used in signal processing. The frequency modulation reflectometer in the KSTAR applies this technique to get the phase information from the mixer output measurements. Since WT is a time consuming process, it is difficult to calculate the density profile in real time. The data analysis time, however, can be significantly reduced by the use of the Graphics Processing Unit (GPU), with its powerful computing capability, in WT. A bottle neck in the KSTAR data processing exists in the data input and output (IO) process between the CPU and its peripheral devices. In this paper, the details of the WT implementation assisted by a GPU in the KSTAR reflectometer are presented and the consequent performance improvement is reported. The real time density profile calculation from the reflectometer measurements is also discussed.

  5. A graphical simulator for active learning of MRI basics

    Wilhjelm, Jens E.; Duun-Henriksen, Jonas; Hanson, Lars G.

    2014-01-01

    This paper presents a MATLAB-based graphical user interface (GUI) for simulation of a simple magnetic resonance imaging (MRI) scanner that the student can operate and obtain results with. It is intended for the students in an introductory course in medical imaging and provides the students with a...

  6. Mouse Movement and Probabilistic Graphical Models Based E-Learning Activity Recognition Improvement Possibilistic Model

    Elbahi, Anis; Omri, Mohamed Nazih; Mahjoub, Mohamed Ali,; Garrouch, Kamel

    2016-01-01

    Automatically recognizing the e-learning activities is an important task for improving the online learning process. Probabilistic graphical models such as hidden Markov models and conditional random fields have been successfully used in order to identify a Web users activity. For such models, the sequences of observation are crucial for training and inference processes. Despite the efficiency of these probabilistic graphical models in segmenting and labeling stochastic sequences, their perfor...

  7. A novel R-package graphic user interface for the analysis of metabonomic profiles

    Villa Palmira

    2009-10-01

    Full Text Available Abstract Background Analysis of the plethora of metabolites found in the NMR spectra of biological fluids or tissues requires data complexity to be simplified. We present a graphical user interface (GUI for NMR-based metabonomic analysis. The "Metabonomic Package" has been developed for metabonomics research as open-source software and uses the R statistical libraries. Results The package offers the following options: Raw 1-dimensional spectra processing: phase, baseline correction and normalization. Importing processed spectra. Including/excluding spectral ranges, optional binning and bucketing, detection and alignment of peaks. Sorting of metabolites based on their ability to discriminate, metabolite selection, and outlier identification. Multivariate unsupervised analysis: principal components analysis (PCA. Multivariate supervised analysis: partial least squares (PLS, linear discriminant analysis (LDA, k-nearest neighbor classification. Neural networks. Visualization and overlapping of spectra. Plot values of the chemical shift position for different samples. Furthermore, the "Metabonomic" GUI includes a console to enable other kinds of analyses and to take advantage of all R statistical tools. Conclusion We made complex multivariate analysis user-friendly for both experienced and novice users, which could help to expand the use of NMR-based metabonomics.

  8. Systems Biology Graphical Notation: Activity Flow language Level 1 Version 1.2.

    Mi, Huaiyu; Schreiber, Falk; Moodie, Stuart; Czauderna, Tobias; Demir, Emek; Haw, Robin; Luna, Augustin; Le Novère, Nicolas; Sorokin, Anatoly; Villéger, Alice

    2015-01-01

    The Systems Biological Graphical Notation (SBGN) is an international community effort for standardized graphical representations of biological pathways and networks. The goal of SBGN is to provide unambiguous pathway and network maps for readers with different scientific backgrounds as well as to support efficient and accurate exchange of biological knowledge between different research communities, industry, and other players in systems biology. Three SBGN languages, Process Description (PD), Entity Relationship (ER) and Activity Flow (AF), allow for the representation of different aspects of biological and biochemical systems at different levels of detail. The SBGN Activity Flow language represents the influences of activities among various entities within a network. Unlike SBGN PD and ER that focus on the entities and their relationships with others, SBGN AF puts the emphasis on the functions (or activities) performed by the entities, and their effects to the functions of the same or other entities. The nodes (elements) describe the biological activities of the entities, such as protein kinase activity, binding activity or receptor activity, which can be easily mapped to Gene Ontology molecular function terms. The edges (connections) provide descriptions of relationships (or influences) between the activities, e.g., positive influence and negative influence. Among all three languages of SBGN, AF is the closest to signaling pathways in biological literature and textbooks, but its well-defined semantics offer a superior precision in expressing biological knowledge. PMID:26528563

  9. Visual dream content, graphical representation and EEG alpha activity in congenitally blind subjects.

    Bértolo, Helder; Paiva, Teresa; Pessoa, Lara; Mestre, Tiago; Marques, Raquel; Santos, Rosa

    2003-02-01

    It is currently claimed that congenitally blind do not have visual imagery and are therefore unable to present visual contents in their dreams. The aim of our study was to quantitatively evaluate the existence of visual imagery in born-blind dreams and to correlate it with objective measures, such as sleep EEG frequency components, namely with alpha attenuation (regarded as an indicator of visual activity), and graphical analysis of dream pictorial representations. The investigation was carried out via simultaneous recordings of dream reports and polysomnography, during nocturnal sleep at volunteers' homes; scheduled regular awakenings during the night provided the data for dream and EEG analysis. In the morning, subjects were asked to make a drawing of their dream images. Congenitally blind (n=10) were comparable to normal sighted subjects (n=9): the two groups presented equivalent visual activity indices, and no differences in the analysis of graphical representation of dreaming imagery. However, blind subjects presented a lower rate of dream recall than sighted (27% versus 42%). Both groups had significant negative correlation between Visual Activity Index (VAI) and alpha power in the central and occipital O2 derivations (blind: C4: r=-0.615, Pblind in O1 (r=-0.573, PBlind individuals have significantly lower alpha activity in the central derivation. In conclusion, the congenitally blind have visual content in their dreams and are able to draw it and, as expected, their VAI is negatively correlated with EEG alpha power. PMID:12527101

  10. On active current selection for Lagrangian profilers

    Jouffroy, Jerome; Zhou, Qiuyang; Zielinski, Oliver

    2013-01-01

    Autonomous Lagrangian profilers are now widely used as measurement and monitoring platforms, notably in observation programs as Argo. In a typical mode of operation, the profilers drift passively at their parking depth before making a vertical profile to go back to the surface. This paper presents...... simple and computationally-efficient control strategies to actively select and use ocean currents so that a profiler can autonomously reach a desired destination. After briefly presenting a typical profiler and possible mechanical modifications for a coastal environment, we introduce simple mathematical...

  11. The computer graphics metafile

    Henderson, LR; Shepherd, B; Arnold, D B

    1990-01-01

    The Computer Graphics Metafile deals with the Computer Graphics Metafile (CGM) standard and covers topics ranging from the structure and contents of a metafile to CGM functionality, metafile elements, and real-world applications of CGM. Binary Encoding, Character Encoding, application profiles, and implementations are also discussed. This book is comprised of 18 chapters divided into five sections and begins with an overview of the CGM standard and how it can meet some of the requirements for storage of graphical data within a graphics system or application environment. The reader is then intr

  12. The computer graphics interface

    Steinbrugge Chauveau, Karla; Niles Reed, Theodore; Shepherd, B

    2014-01-01

    The Computer Graphics Interface provides a concise discussion of computer graphics interface (CGI) standards. The title is comprised of seven chapters that cover the concepts of the CGI standard. Figures and examples are also included. The first chapter provides a general overview of CGI; this chapter covers graphics standards, functional specifications, and syntactic interfaces. Next, the book discusses the basic concepts of CGI, such as inquiry, profiles, and registration. The third chapter covers the CGI concepts and functions, while the fourth chapter deals with the concept of graphic obje

  13. HT-BONE: a graphical user interface for the identification of bone profiles in CT images via extended Hough transform

    Campi, Cristina; Perasso, Annalisa; Beltrametti, Mauro C.; Piana, Michele; Sambuceti, Gianmario; Massone, Anna Maria

    2016-03-01

    It has been recently proved that the computational analysis of X-ray Computed Tomography (CT) images allows clinicians to assess the alteration of compact bone asset due to hematological diseases. HT-BONE implements a new method, based on an extension of the Hough transform (HT) to a wide class of algebraic curves, for accurately measuring global and regional geometric properties of trabecular and compact bone districts. In the case of CT/PET analysis, the segmentation of the CT images provides masks for Positron Emission Tomography (PET) data, extracting the metabolic activity in the region surrounded by compact bone tissue. HT-BONE offers an intuitive, user-friendly, Matlab-based Graphical User Interface (GUI) for all input/output procedures and the automatic managing of the segmentation process also from non-expert users: the CT/PET data can be loaded and browsed easily and the only pre-preprocessing required from the user is the drawing of Regions Of Interest (ROIs) around the bone districts under consideration. For each bone district, specific families of curves, whose reliability has been already tested in previous works, is automatically selected for the recognition task via HT. As output, the software returns masks of the segmented compact bone regions, images of the Standard Uptake Values (SUV) in the masked regions of PET slices, and the values of the parameters in the curve equations utilized in the HT procedure. This information can be used for all pathologies and clinical conditions for which the alteration of the compact bone asset or bone marrow distribution plays a crucial role.

  14. Using Multimedia Graphic Organizer Software in the Prewriting Activities of Primary School Students: What Are the Benefits?

    Lorenz, Barbara; Green, Tim; Brown, Abbie

    2009-01-01

    The use of multimedia graphic organizer software and how it influenced the prewriting process for primary school children were evaluated. An analysis of writing samples generated by second-grade students with diverse writing abilities was carried out. Students were given two opportunities to participate in prewriting activities--one without and…

  15. R graphics

    Murrell, Paul

    2005-01-01

    R is revolutionizing the world of statistical computing. Powerful, flexible, and best of all free, R is now the program of choice for tens of thousands of statisticians. Destined to become an instant classic, R Graphics presents the first complete, authoritative exposition on the R graphical system. Paul Murrell, widely known as the leading expert on R graphics, has developed an in-depth resource that takes nothing for granted and helps both neophyte and seasoned users master the intricacies of R graphics. After an introductory overview of R graphics facilities, the presentation first focuses

  16. Using Activity Metrics for DEVS Simulation Profiling

    Muzy A.

    2014-01-01

    Full Text Available Activity metrics can be used to profile DEVS models before and during the simulation. It is critical to get good activity metrics of models before and during their simulation. Having a means to compute a-priori activity of components (analytic activity may be worth when simulating a model (or parts of it for the first time. After, during the simulation, analytic activity can be corrected using dynamic one. In this paper, we introduce McCabe cyclomatic complexity metric (MCA to compute analytic activity. Both static and simulation activity metrics have been implemented through a plug-in of the DEVSimPy (DEVS Simulator in Python language environment and applied to DEVS models.

  17. Resurfacing Graphics

    Prof. Patty K. Wongpakdee

    2013-01-01

    “Resurfacing Graphics” deals with the subject of unconventional design, with the purpose of engaging the viewer to experience the graphics beyond paper’s passive surface. Unconventional designs serve to reinvigorate people, whose senses are dulled by the typical, printed graphics, which bombard them each day. Today’s cutting-edge designers, illustrators and artists utilize graphics in a unique manner that allows for tactile interaction. Such works serve as valuable teaching models and encoura...

  18. Graphic arts standards update: 1996

    McDowell, David Q.

    1996-03-01

    Color definition and data exchange continue to be dominant themes in both the US and international graphic arts standards activity. However, there is a growing understanding of the role that metrology and printing process definition play in helping define stable process conditions to which color characterization data can be related. Standards have already been published that define the requirements for color measurement and computation, scanner input characterization targets, four-color output characterization data sets, and graphic arts applications of densitometry. Work continues on standards relating to ink testing and ink color specifications. The numerical specifications of SWOP proof printing have been captured in ANSI standard CGATS.6-1995. Work has been completed, and Technical Report ANSI CGATS TR 001-1995 has been published, that relates the colorimetry of the printed sheet to the CMYK input for press proofing meeting SWOP and CGATS.6 specifications. Work is ongoing to provide similar data for other printing processes. Such color characterization data is key to the development of color profiles for standard printing conditions. Specifications for color profiles, to allow color definitions to be moved between color management systems, are being developed by the International Color Consortium. The existing graphic arts data exchange, process control, and color related standards are summarized and the current status of work in progress is reviewed. In addition, the interaction of the formal standards programs and other industry-driven specification activity is discussed.

  19. Graphic Storytelling

    Thompson, John

    2009-01-01

    Graphic storytelling is a medium that allows students to make and share stories, while developing their art communication skills. American comics today are more varied in genre, approach, and audience than ever before. When considering the impact of Japanese manga on the youth, graphic storytelling emerges as a powerful player in pop culture. In…

  20. Graphic Review

    Breiting, Søren

    2002-01-01

    Introduktion til 'graphic review' som en metode til at føre forståelse fra en undervisngsgang til den næste i læreruddannelse og grundskole.......Introduktion til 'graphic review' som en metode til at føre forståelse fra en undervisngsgang til den næste i læreruddannelse og grundskole....

  1. Graphics gems

    Glassner, Andrew S

    1993-01-01

    ""The GRAPHICS GEMS Series"" was started in 1990 by Andrew Glassner. The vision and purpose of the Series was - and still is - to provide tips, techniques, and algorithms for graphics programmers. All of the gems are written by programmers who work in the field and are motivated by a common desire to share interesting ideas and tools with their colleagues. Each volume provides a new set of innovative solutions to a variety of programming problems.

  2. Graphic notation

    Bergstrøm-Nielsen, Carl

    1992-01-01

    Texbook to be used along with training the practise of graphic notation. Describes method; exercises; bibliography; collection of examples. If you can read Danish, please refer to that edition which is by far much more updated.......Texbook to be used along with training the practise of graphic notation. Describes method; exercises; bibliography; collection of examples. If you can read Danish, please refer to that edition which is by far much more updated....

  3. Activity-Based Protein Profiling of Microbes

    Sadler, Natalie C.; Wright, Aaron T.

    2015-02-01

    Activity-Based Protein Profiling (ABPP) in conjunction with multimodal characterization techniques has yielded impactful findings in microbiology, particularly in pathogen, bioenergy, drug discovery, and environmental research. Using small molecule chemical probes that react irreversibly with specific proteins or protein families in complex systems has provided insights in enzyme functions in central metabolic pathways, drug-protein interactions, and regulatory protein redox, for systems ranging from photoautotrophic cyanobacteria to mycobacteria, and combining live cell or cell extract ABPP with proteomics, molecular biology, modeling, and other techniques has greatly expanded our understanding of these systems. New opportunities for application of ABPP to microbial systems include: enhancing protein annotation, characterizing protein activities in myriad environments, and reveal signal transduction and regulatory mechanisms in microbial systems.

  4. Graphical processing unit implementation of an integrated shape-based active contour: Application to digital pathology

    Sahirzeeshan Ali

    2011-01-01

    Full Text Available Commodity graphics hardware has become a cost-effective parallel platform to solve many general computational problems. In medical imaging and more so in digital pathology, segmentation of multiple structures on high-resolution images, is often a complex and computationally expensive task. Shape-based level set segmentation has recently emerged as a natural solution to segmenting overlapping and occluded objects. However the flexibility of the level set method has traditionally resulted in long computation times and therefore might have limited clinical utility. The processing times even for moderately sized images could run into several hours of computation time. Hence there is a clear need to accelerate these segmentations schemes. In this paper, we present a parallel implementation of a computationally heavy segmentation scheme on a graphical processing unit (GPU. The segmentation scheme incorporates level sets with shape priors to segment multiple overlapping nuclei from very large digital pathology images. We report a speedup of 19× compared to multithreaded C and MATLAB-based implementations of the same scheme, albeit with slight reduction in accuracy. Our GPU-based segmentation scheme was rigorously and quantitatively evaluated for the problem of nuclei segmentation and overlap resolution on digitized histopathology images corresponding to breast and prostate biopsy tissue specimens.

  5. Graphics gems

    Heckbert, Paul S

    1994-01-01

    Graphics Gems IV contains practical techniques for 2D and 3D modeling, animation, rendering, and image processing. The book presents articles on polygons and polyhedral; a mix of formulas, optimized algorithms, and tutorial information on the geometry of 2D, 3D, and n-D space; transformations; and parametric curves and surfaces. The text also includes articles on ray tracing; shading 3D models; and frame buffer techniques. Articles on image processing; algorithms for graphical layout; basic interpolation methods; and subroutine libraries for vector and matrix algebra are also demonstrated. Com

  6. An atomic orbital-based formulation of the complete active space self-consistent field method on graphical processing units

    Hohenstein, Edward G.; Luehr, Nathan; Ufimtsev, Ivan S.; Martínez, Todd J., E-mail: toddjmartinez@gmail.com [Department of Chemistry and the PULSE Institute, Stanford University, Stanford, California 94305 (United States); SLAC National Accelerator Laboratory, Menlo Park, California 94025 (United States)

    2015-06-14

    Despite its importance, state-of-the-art algorithms for performing complete active space self-consistent field (CASSCF) computations have lagged far behind those for single reference methods. We develop an algorithm for the CASSCF orbital optimization that uses sparsity in the atomic orbital (AO) basis set to increase the applicability of CASSCF. Our implementation of this algorithm uses graphical processing units (GPUs) and has allowed us to perform CASSCF computations on molecular systems containing more than one thousand atoms. Additionally, we have implemented analytic gradients of the CASSCF energy; the gradients also benefit from GPU acceleration as well as sparsity in the AO basis.

  7. An atomic orbital-based formulation of the complete active space self-consistent field method on graphical processing units

    Hohenstein, Edward G.; Luehr, Nathan; Ufimtsev, Ivan S.; Martínez, Todd J.

    2015-06-01

    Despite its importance, state-of-the-art algorithms for performing complete active space self-consistent field (CASSCF) computations have lagged far behind those for single reference methods. We develop an algorithm for the CASSCF orbital optimization that uses sparsity in the atomic orbital (AO) basis set to increase the applicability of CASSCF. Our implementation of this algorithm uses graphical processing units (GPUs) and has allowed us to perform CASSCF computations on molecular systems containing more than one thousand atoms. Additionally, we have implemented analytic gradients of the CASSCF energy; the gradients also benefit from GPU acceleration as well as sparsity in the AO basis.

  8. On Active Current Selection for Lagrangian Profilers

    J. Jouffroy

    2013-01-01

    Full Text Available Autonomous Lagrangian profilers are now widely used as measurement and monitoring platforms, notably in observation programs as Argo. In a typical mode of operation, the profilers drift passively at their parking depthbefore making a vertical profile to go back to the surface. This paperpresents simple and computationally-efficient control strategies to activelyselect and use ocean currents so that a profiler can autonomously reach adesired destination. After briefly presenting a typical profiler andpossible mechanical modifications for a coastal environment, we introducesimple mathematical models for the profiler and the currents it will use. Wethen present simple feedback controllers that, using the direction of thecurrents and taking into account the configuration of the environment(coastal or deep-sea, is able to steer the profiler to any desiredhorizontal location. To illustrate the approach, a few results are presentedusing both simulated currents and real current velocity profiles from theNorth Sea.

  9. Graphic notation

    Bergstrøm-Nielsen, Carl

    2010-01-01

    Graphic notation is taught to music therapy students at Aalborg University in both simple and elaborate forms. This is a method of depicting music visually, and notations may serve as memory aids, as aids for analysis and reflection, and for communication purposes such as supervision or within...

  10. Resurfacing Graphics

    Prof. Patty K. Wongpakdee

    2013-06-01

    Full Text Available “Resurfacing Graphics” deals with the subject of unconventional design, with the purpose of engaging the viewer to experience the graphics beyond paper’s passive surface. Unconventional designs serve to reinvigorate people, whose senses are dulled by the typical, printed graphics, which bombard them each day. Today’s cutting-edge designers, illustrators and artists utilize graphics in a unique manner that allows for tactile interaction. Such works serve as valuable teaching models and encourage students to do the following: 1 investigate the trans-disciplines of art and technology; 2 appreciate that this approach can have a positive effect on the environment; 3 examine and research other approaches of design communications and 4 utilize new mediums to stretch the boundaries of artistic endeavor. This paper examines how visuals communicators are “Resurfacing Graphics” by using atypical surfaces and materials such as textile, wood, ceramics and even water. Such non-traditional transmissions of visual language serve to demonstrate student’s overreliance on paper as an outdated medium. With this exposure, students can become forward-thinking, eco-friendly, creative leaders by expanding their creative breadth and continuing the perpetual exploration for new ways to make their mark. 

  11. Resurfacing Graphics

    Prof. Patty K. Wongpakdee

    2013-06-01

    Full Text Available “Resurfacing Graphics” deals with the subject of unconventional design, with the purpose of engaging the viewer to experience the graphics beyond paper’s passive surface. Unconventional designs serve to reinvigorate people, whose senses are dulled by the typical, printed graphics, which bombard them each day. Today’s cutting-edge designers, illustrators and artists utilize graphics in a unique manner that allows for tactile interaction. Such works serve as valuable teaching models and encourage students to do the following: 1 investigate the trans-disciplines of art and technology; 2 appreciate that this approach can have a positive effect on the environment; 3 examine and research other approaches of design communications and 4 utilize new mediums to stretch the boundaries of artistic endeavor. This paper examines how visuals communicators are “Resurfacing Graphics” by using atypical surfaces and materials such as textile, wood, ceramics and even water. Such non-traditional transmissions of visual language serve to demonstrate student’s overreliance on paper as an outdated medium. With this exposure, students can become forward-thinking, eco-friendly, creative leaders by expanding their creative breadth and continuing the perpetual exploration for new ways to make their mark.

  12. Software for Applicon graphics system support of the NNWSI area-to-location screening activity

    A comprehensive system study has been performed to screen the Nevada Research and Development Area (NRDA) of the Nevada Test Site (NTS) and nearby areas for relatively favorable locations of about 10 square miles for the permanent disposal of radioactive waste in a mined repository. The purpose of this screening was to use information available during the summer of 1981 to identify such locations. The results of this screening will allow more informed decisions by the Department of Energy's Nevada Nuclear Waste Storage Investigations Project as to where future repository exploration could be concentrated to optimize the chances that the locations chosen for characterization would qualify as a licensed repository site. The methods used for, and the results of, this study are described by S. Sinnock and J. Fernandez in their report, Summary and Conclusions of the NNWSI Area-to-Location Screening Activity (NVO-247). This report is intended to describe the computer support developed for the screening activity and, as such, should not be treated as a stand-alone document, but as a supplement to the above summary report. This report complements two other supplemental reports dealing with 16 physical data bases for screening and the objectives of the screening methodology. Together, these four reports fully describe the screening activity of the Nevada Nuclear Waste Storage Investigations Project

  13. Design Graphics

    1990-01-01

    A mathematician, David R. Hedgley, Jr. developed a computer program that considers whether a line in a graphic model of a three-dimensional object should or should not be visible. Known as the Hidden Line Computer Code, the program automatically removes superfluous lines and displays an object from a specific viewpoint, just as the human eye would see it. An example of how one company uses the program is the experience of Birdair which specializes in production of fabric skylights and stadium covers. The fabric called SHEERFILL is a Teflon coated fiberglass material developed in cooperation with DuPont Company. SHEERFILL glazed structures are either tension structures or air-supported tension structures. Both are formed by patterned fabric sheets supported by a steel or aluminum frame or cable network. Birdair uses the Hidden Line Computer Code, to illustrate a prospective structure to an architect or owner. The program generates a three- dimensional perspective with the hidden lines removed. This program is still used by Birdair and continues to be commercially available to the public.

  14. Inter-level Scaffolding and Sequences of Representational Activities in Teaching a Chemical System with Graphical Simulations

    Li, Na; Black, John B.

    2016-05-01

    Chemistry knowledge can be represented at macro-, micro- and symbolic levels, and learning a chemistry topic requires students to engage in multiple representational activities. This study focused on scaffolding for inter-level connection-making in learning chemistry knowledge with graphical simulations. We also tested whether different sequences of representational activities produced different student learning outcomes in learning a chemistry topic. A sample of 129 seventh graders participated in this study. In a simulation-based environment, participants completed three representational activities to learn several ideal gas law concepts. We conducted a 2 × 3 factorial design experiment. We compared two scaffolding conditions: (1) the inter-level scaffolding condition in which participants received inter-level questions and experienced the dynamic link function in the simulation-based environment and (2) the intra-level scaffolding condition in which participants received intra-level questions and did not experience the dynamic link function. We also compared three different sequences of representational activities: macro-symbolic-micro, micro-symbolic-macro and symbolic-micro-macro. For the scaffolding variable, we found that the inter-level scaffolding condition produced significantly better performance in both knowledge comprehension and application, compared to the intra-level scaffolding condition. For the sequence variable, we found that the macro-symbolic-micro sequence produced significantly better knowledge comprehension performance than the other two sequences; however, it did not benefit knowledge application performance. There was a trend that the treatment group who experienced inter-level scaffolding and the micro-symbolic-macro sequence achieved the best knowledge application performance.

  15. Multicomponent He I 10830 {\\AA} profiles in an active filament

    Sasso, C; Solanki, S K

    2011-01-01

    We present new spectropolarimetric observations of the chromospheric He I 10830 {\\AA} multiplet observed in a filament during its phase of activity. The data were recorded with the new Tenerife Infrared Polarimeter (TIP-II) at the German Vacuum Tower Telescope (VTT) on 2005 May 18. We inverted the He Stokes profiles using multiple atmospheric components. The observed He Stokes profiles display a remarkably wide variety of shapes. Most of the profiles show very broad Stokes I absorptions and complex and spatially variable Stokes V signatures. The inversion of the profiles shows evidence of different atmospheric blue- and redshifted components of the He I lines within the resolution element (1 arcsec), with supersonic velocities of up to 100 km/s. Up to five different atmospheric components are found in the same profile. We show that even these complex profiles can be reliably inverted.

  16. Rapid identification of Enterobacteriaceae with microbial enzyme activity profiles.

    Godsey, J H; Matteo, M R; Shen, D; Tolman, G; Gohlke, J R

    1981-01-01

    A total of 539 clinical isolates belonging to 10 species of the Enterobacteriaceae family were identified by enzyme activity profiles within 30 min of test inoculation. Each isolate was grown at 37 degrees C for 18 h on Mueller-Hinton agar and suspended to an optical density of 200 Klett units on 0.85% saline. Enzyme activity profiles were obtained by inoculating 18 fluorogenic substrates with the standardized bacterial suspension and monitoring initial rates of hydrolysis over the first 30 m...

  17. Cognitive profile and activities of daily living

    Borgwardt, Line Gutte; Thuesen, A M; Olsen, K J;

    2015-01-01

    BACKGROUND: Alpha-mannosidosis (OMIM 248500) (AM) is a rare lysosomal storage disease caused by a deficiency of the alpha-mannosidase enzyme. The typical signs consist of hearing impairment, intellectual disabilities, coarse facial features and motor function disturbances. We report on the...... cognitive function and activities of daily living in patients with AM. METHODS: Thirty five AM patients, age 6-35 years, were included in the study. As a cognitive function test, we used the Leiter international performance scale-revised (Leiter-R), which consists of two batteries: the visual function and...... assess that this group of patients has, despite their intellectual disabilities, a potential for continuous cognitive development, especially during childhood and early teenage years. This should be included and supported in the individual educational planning....

  18. Profiles and Pauses: Two Practical Activities for the Writing Class

    Ernest Hall

    1998-01-01

    Full Text Available Abstract : This article describes two classroom activities, "Profiling" and "Pause Analysis", that can be successfully used in ESL writing classes. "Profiling" addresses such problems as poor development of ideas, simplistic ideas, and lack of coherence in written texts. "Pause Analysis" focusses on the thinking processes that students engage in while drafting text, processes such as searching for ideas, evaluat­ing ideas, and postponing ideas. Both activities enable the instructor to assume the role of intervener in the students' writing processes, rather than evaluator of the text produced. In drawing The attention of the student write to both product and process, "Profiling" and "Pause Analysis" help them develop an awareness of the relation-ship between ideas in English expository text and the thinking pro­cesses that writers engage in while drafting such text.

  19. Profiles for voltage-activated currents are multiphasic, not curvilinear

    Nissen, Per

    2016-01-01

    Data for voltage-activation of a potassium channel (Matulef et al. Proc Natl Acad Sci USA 110: 17886-17891. 2013) were, as conventionally done, fitted by the authors by a Boltzmann function, i.e. by a curvilinear profile. Reanalysis of the data reveals however that this interpretation must be rejected in favor of a multiphasic profile, a series of straight lines separated by discontinuous transitions, quite often in the form of noncontiguities (jumps). In contrast to the generally very poor fits to the Boltzmann profiles, the fits to multiphasic profiles are very good. (For the four replicates, the average deviations from the Boltzmann curves were 10- to 100-fold larger than the deviations from the multiphasic profiles.) The difference in the median values was statistically highly significant, P<0.001 in most cases. For the mean values the deviations from the Boltzmann curve were 20-fold larger than the deviations from the multiphasic profile, and the difference in the median values was also highly signifi...

  20. Activity-Based Protein Profiling of Rhomboid Proteases in Liposomes

    Wolf, E. V.; Seybold, M.; Hadravová, Romana; Stříšovský, Kvido; Verhelst, S. H. L.

    2015-01-01

    Roč. 16, č. 11 (2015), s. 1616-1621. ISSN 1439-4227 R&D Projects: GA MŠk(CZ) LK11206; GA MŠk LO1302 Institutional support: RVO:61388963 Keywords : activity -based protein profiling * chemical probes * inhibitors * intramembrane proteases * liposomes Subject RIV: CE - Biochemistry Impact factor: 3.088, year: 2014

  1. Surface activity, lipid profiles and their implications in cervical cancer.

    Preetha A

    2005-01-01

    Full Text Available Background: The profiles of lipids in normal and cancerous tissues may differ revealing information about cancer development and progression. Lipids being surface active, changes in lipid profiles can manifest as altered surface activity profiles. Langmuir monolayers offer a convenient model for evaluating surface activity of biological membranes. Aims: The aims of this study were to quantify phospholipids and their effects on surface activity of normal and cancerous human cervical tissues as well as to evaluate the role of phosphatidylcholine (PC and sphingomyelin (SM in cervical cancer using Langmuir monolayers. Methods and Materials: Lipid quantification was done using thin layer chromatography and phosphorus assay. Surface activity was evaluated using Langmuir monolayers. Monolayers were formed on the surface of deionized water by spreading tissue organic phase corresponding to 1 mg of tissue and studying their surface pressure-area isotherms at body temperature. The PC and SM contents of cancerous human cervical tissues were higher than those of the normal human cervical tissues. Role of PC and SM were evaluated by adding varying amounts of these lipids to normal cervical pooled organic phase. Statistical analysis: Student′s t-test (p < 0.05 and one-way analysis of variance (ANOVA was used. Results: Our results reveals that the phosphatidylglycerol level in cancerous cervical tissue was nearly five folds higher than that in normal cervical tissue. Also PC and sphingomyelin SM were found to be the major phospholipid components in cancerous and normal cervical tissues respectively. The addition of either 1.5 µg DPPC or 0.5 µg SM /mg of tissue to the normal organic phase changed its surface activity profile to that of the cancerous tissues. Statistically significant surface activity parameters showed that PC and SM have remarkable roles in shifting the normal cervical lipophilic surface activity towards that of cancerous lipophilic

  2. Impurity profile tracking for active pharmaceutical ingredients: case reports.

    Zhou, Lili; Mao, Bing; Reamer, Robert; Novak, Tom; Ge, Zhihong

    2007-06-28

    Tracking the impurity profile of an active pharmaceutical ingredient (API) is a very important task for all stages of drug development. A systematic approach for tracking impurity profile of API is described. Various real pharmaceutical applications are presented through successful examples of impurity profile tracking for three different novel APIs. These include MK-0969, an M3 antagonist; MK-0677, an oral-active growth hormone secretagogue and API-A, a cathepsin K inhibitor. A general strategy including selection of a reversed phase high performance liquid chromatographic (RP-HPLC) impurity profile method based on screening various stationary phases and changing the pH of the mobile phase and elucidation of impurity structures through the utilization of LC-MS, preparative-LC and NMR is demonstrated. A series of studies were conducted on the peak purity check by using the LC-UV diode-array and LC-MS detections. The advantages and disadvantages of each technique in the evaluation of peak purity are discussed. PMID:17142001

  3. Graphical Rasch models

    Kreiner, Svend; Christensen, Karl Bang

    Rasch models; Partial Credit models; Rating Scale models; Item bias; Differential item functioning; Local independence; Graphical models......Rasch models; Partial Credit models; Rating Scale models; Item bias; Differential item functioning; Local independence; Graphical models...

  4. Graphic Turbulence Guidance

    National Oceanic and Atmospheric Administration, Department of Commerce — Forecast turbulence hazards identified by the Graphical Turbulence Guidance algorithm. The Graphical Turbulence Guidance product depicts mid-level and upper-level...

  5. Heart rate and activity profile for young female soccer players

    Barbero Álvarez, José Carlos; Gómez López, Maite; Barbero Álvarez, Verónica; Granda Vera, Juan; Castagna, Carlo

    2008-01-01

    The physical and physiological demands of high-level male soccer have been studied extensively, while few studies have investigated the demands placed on females during match-play, however, there is no information available about the heart rate and activity profile of young female soccer players during match play. Therefore, the aim of this study was to examine cardiovascular (heart-rates HR) and physical demands of young female soccer players during a match. Players were observed during a fr...

  6. Hidden Markov Models for the Activity Profile of Terrorist Groups

    Raghavan, Vasanthan; Tartakovsky, Alexander G

    2012-01-01

    The main focus of this work is on developing models for the activity profile of a terrorist group, detecting sudden spurts and downfalls in this profile, and in general, tracking it over a period of time. Toward this goal, a d-state hidden Markov model (HMM) that captures the latent states underlying the dynamics of the group and thus its activity profile is developed. The simplest setting of d = 2 corresponds to the case where the dynamics are coarsely quantized as Active and Inactive, respectively. Two strategies for spurt detection and tracking are developed here: a model-independent strategy that uses the exponential weighted moving-average (EWMA) filter to track the strength of the group as measured by the number of attacks perpetrated by it, and a state estimation strategy that exploits the underlying HMM structure. The EWMA strategy is robust to modeling uncertainties and errors, and tracks persistent changes (changes that last for a sufficiently long duration) in the strength of the group. On the othe...

  7. Deterministic Graphical Games Revisited

    Andersson, Daniel; Hansen, Kristoffer Arnsfelt; Miltersen, Peter Bro; Sørensen, Troels Bjerre

    2008-01-01

    We revisit the deterministic graphical games of Washburn. A deterministic graphical game can be described as a simple stochastic game (a notion due to Anne Condon), except that we allow arbitrary real payoffs but disallow moves of chance. We study the complexity of solving deterministic graphical...

  8. Enzyme activity measurement via spectral evolution profiling and PARAFAC

    Baum, Andreas; Meyer, Anne S.; Garcia, Javier Lopez;

    2013-01-01

    The recent advances in multi-way analysis provide new solutions to traditional enzyme activity assessment. In the present study enzyme activity has been determined by monitoring spectral changes of substrates and products in real time. The method relies on measurement of distinct spectral...... fingerprints of the reaction mixture at specific time points during the course of the whole enzyme catalyzed reaction and employs multi-way analysis to detect the spectral changes. The methodology is demonstrated by spectral evolution profiling of Fourier Transform Infrared (FTIR) spectral fingerprints using...

  9. Phenotype microarray profiling of the antibacterial activity of red cabbage

    Hafidh RR

    2012-06-01

    Full Text Available Background: Functional food can be a potent source of wide array of biocomonents with antimicrobial activity. We investigated the antibacterial activity of red cabbage (RC extract on Gram negative and positive ATCC strains. Most intersting, we, for the first time, explored and analysed the complete phenotypic profile of RC-treated bacteria using Omnilog Phenotype Microarray. Results: This study revealed that the phenotype microarray (PM screen was a valuable tool in the search for compounds and their antibacterial mechanisms that can inhibit bacterial growth by affecting certain metabolic pathways. It was shown that RC exerted remarkable antibacterial effect on S. aureus and E. coli bacteria, and PM showed a wide range phenotypic profile of the exerted RC antibacterial activity. RC targeted the peptide, carbon, nutriontional assembly, and sulfur metbolic pathways altogether. The peptidoglycan synthesis pathway was inferred to be targeted by RC extract at a metabolic point different from other available cell wall-targeting drugs; these could be hot targets for the discovery of new therapy for many problematic microbes.Conclusions: Taken together, the phenotype microarray for functional food and medicinal plants can be a very useful tool for profiling their antimicrobial activity. Moreover, extracts of functional food can exert antibacterial activity by hitting a wide range of metabolic pathways, at the same time leading to very difficult condition for bacteria to rapidly develop resistance. Therefore, using functional foods or medicinal plants as such, or as extracts, can be superior on mono-targeting antibiotics if the optimal concentrations and conditions of these functional foods were sought.

  10. The PC graphics handbook

    Sanchez, Julio

    2003-01-01

    Part I - Graphics Fundamentals PC GRAPHICS OVERVIEW History and Evolution Short History of PC Video PS/2 Video Systems SuperVGA Graphics Coprocessors and Accelerators Graphics Applications State-of-the-Art in PC Graphics 3D Application Programming Interfaces POLYGONAL MODELING Vector and Raster Data Coordinate Systems Modeling with Polygons IMAGE TRANSFORMATIONS Matrix-based Representations Matrix Arithmetic 3D Transformations PROGRAMMING MATRIX TRANSFORMATIONS Numeric Data in Matrix Form Array Processing PROJECTIONS AND RENDERING Perspective The Rendering Pipeline LIGHTING AND SHADING Lightin

  11. Graphics gems II

    Arvo, James

    1991-01-01

    Graphics Gems II is a collection of articles shared by a diverse group of people that reflect ideas and approaches in graphics programming which can benefit other computer graphics programmers.This volume presents techniques for doing well-known graphics operations faster or easier. The book contains chapters devoted to topics on two-dimensional and three-dimensional geometry and algorithms, image processing, frame buffer techniques, and ray tracing techniques. The radiosity approach, matrix techniques, and numerical and programming techniques are likewise discussed.Graphics artists and comput

  12. Universal Temporal Profile of Replication Origin Activation in Eukaryotes

    Goldar, Arach

    2011-03-01

    The complete and faithful transmission of eukaryotic genome to daughter cells involves the timely duplication of mother cell's DNA. DNA replication starts at multiple chromosomal positions called replication origin. From each activated replication origin two replication forks progress in opposite direction and duplicate the mother cell's DNA. While it is widely accepted that in eukaryotic organisms replication origins are activated in a stochastic manner, little is known on the sources of the observed stochasticity. It is often associated to the population variability to enter S phase. We extract from a growing Saccharomyces cerevisiae population the average rate of origin activation in a single cell by combining single molecule measurements and a numerical deconvolution technique. We show that the temporal profile of the rate of origin activation in a single cell is similar to the one extracted from a replicating cell population. Taking into account this observation we exclude the population variability as the origin of observed stochasticity in origin activation. We confirm that the rate of origin activation increases in the early stage of S phase and decreases at the latter stage. The population average activation rate extracted from single molecule analysis is in prefect accordance with the activation rate extracted from published micro-array data, confirming therefore the homogeneity and genome scale invariance of dynamic of replication process. All these observations point toward a possible role of replication fork to control the rate of origin activation.

  13. Graphical Models with R

    Højsgaard, Søren; Edwards, David; Lauritzen, Steffen

    of these software developments have taken place within the R community, either in the form of new packages or by providing an R ingerface to existing software. This book attempts to give the reader a gentle introduction to graphical modeling using R and the main features of some of these packages. In addition......Graphical models in their modern form have been around since the late 1970s and appear today in many areas of the sciences. Along with the ongoing developments of graphical models, a number of different graphical modeling software programs have been written over the years. In recent years many......, the book provides examples of how more advanced aspects of graphical modeling can be represented and handled within R. Topics covered in the seven chapters include graphical models for contingency tables, Gaussian and mixed graphical models, Bayesian networks and modeling high dimensional data...

  14. Differential migration and activation profile of monocytes after trophoblast interaction.

    Esteban Grasso

    Full Text Available Macrophages at the maternal-placental interface coordinate opposite demands under the control of trophoblast cells such as the response against pathogens on one hand, and apoptotic cell clearance and wound healing with the production of suppressor cytokines. Here, we investigated whether trophoblast cells induce maternal monocyte activation towards an alternative activated macrophage profile and whether bacterial or viral stimuli modulate their migratory properties. We used an in vitro model of the maternal-placental interface represented by co-cultures of CD14+ cells isolated from fertile women with first trimester trophoblast cell line (Swan-71 cells in the presence or absence of pathogen associated molecular pattern (PAMP stimuli lipopolysaccharide (LPS, peptidoglycan (PGN or poly [I:C]. Maternal CD14+ cells showed increased CD16 and CD39 expression, both markers associated to an alternative activation profile, with no changes in CD80 expression after trophoblast cell interaction. These changes were accompanied by increased IL-10 and decreased IL-12 production by CD14+ cells. After stimulation with LPS, PGN or poly [I:C], monocytes co-cultured with trophoblast cells had lower production of TNF-α and IL-1β compared with non co-cultured monocytes. Interestingly, monocyte migration towards trophoblast cells was prevented in the presence of LPS or PGN but not after 24h of stimulation with poly [I:C]. LPS or PGN also decreased CCR5, CXCL-8 and CCL5 expression. Finally, trophoblast cells co-cultured with monocytes in the presence of pathological stimuli failed to increase chemokine expression, indicating a bidirectional effect. In conclusion, trophoblast might 'instruct' maternal monocytes to express an alternative activation profile and restrain their early recruitment under pathological threats as one of the first strategies to avoid potential tissue damage at the maternal-placental interface.

  15. Urban exterior graphical design in botanical garden

    Despot, Katerina; Sandeva, Vaska

    2013-01-01

    Botanical Garden as an art picture and all the content is a strong source of inspiration for the creation of advertising graphics, which is an important segment for the garden, attracting tourists and description of contents. Graphic design is an activity in which a quantity of information gives a comfortable and aesthetic form. This often involves the use of typography, images, colors, and others. Graphic design incorporates in-depth knowledge of the composition and shape, color, color...

  16. Mathematics and Computer Graphic Design Arts

    徐亚非

    2001-01-01

    The relationship between arts and mathematics is very close, computer graphic design is based on digital methodology. The paper reveals the mathematical backgrounds behind graphic design by the example of computer-aided cubic modeling and mathematical exchange methodology. Furthermore, one can get incredible artistic effects if computer graphic designers pay more attention to the probability and use probable numbers and fractal operation in their design activities.Finally, the author also discusses the bidirections between arts and mathematics.

  17. A Survey on Graphical Programming Systems

    Gurudatt Kulkarni; Sathyaraj. R

    2014-01-01

    Recently there has been an increasing interest in the use of graphics to help programming and understanding of computer systems. The Graphical Programming and Program Simulations are exciting areas of active computer science research that show the signs for improving the programming process. An array of different design methodologie s have arisen from research efforts and many graphical programming systems have been developed to address both general programming tasks and speci...

  18. Dynamic Statistical Profiling of Communication Activity in Distributed Applications

    Vetter, J

    2001-10-12

    A complete trace of communication activity for a terascale application is overwhelming in terms of overhead and storage. We propose a novel alternative that enables profiling of the application's communication activity using statistical message sampling during runtime. We have implemented an operational prototype and our evidence shows that this new technique can provide an accurate, low-overhead, tractable alternative for performance analysis of communication activity. Moreover, this alternative enables an assortment of runtime analysis techniques not previously available with post-mortem, trace-based systems. Our assessment of relative performance and coverage of different sampling and analysis methods shows that purely random selection is preferred over counter- and timer-based sampling. Experiments on several applications running up to 128 processors demonstrate the viability of this approach. In particular, on one application, statistical profiling results contradict conclusions based on evidence from tracing. The design of our prototype reveals that parsimonious modifications to the MPI runtime system could facilitate such techniques on production computing systems, and it suggests that this sampling technique could execute continuously for long-running applications.

  19. Graphic arts standards update for 1995

    McDowell, David Q.

    1995-04-01

    Color continues to be an important issue in both the US and international graphic arts standards activity. Standards have been published defining color measurement and computation requirements, scanner input characterization targets, four color output characterization and reflection densitometric data. Work continues on standards relating to ink testing, reference ink color specifications, and printing characterization. Work has been completed, and is being published in an ANSI Technical Report, that relates the measured colorimetric data for printed color to the CMYK input for press proofing meeting SWOP specifications. Implementation of the color standards developed by IT8. CGATS, and ISO/TC130 is being promoted by the Open Systems Color Association (OSCA). Key among the OSCA activities is the development of measurement protocols and a registry of color output characterization data. These color standards are also finding applicability in the work of the International Color Consortium which is developing the interfaces to allow color profile data to be exchanged between color management systems. This presentation will summarize the published graphic arts color-related standards and review the current status of the work in progress.

  20. Chemoproteomic profiling of host and pathogen enzymes active in cholera.

    Hatzios, Stavroula K; Abel, Sören; Martell, Julianne; Hubbard, Troy; Sasabe, Jumpei; Munera, Diana; Clark, Lars; Bachovchin, Daniel A; Qadri, Firdausi; Ryan, Edward T; Davis, Brigid M; Weerapana, Eranthie; Waldor, Matthew K

    2016-04-01

    Activity-based protein profiling (ABPP) is a chemoproteomic tool for detecting active enzymes in complex biological systems. We used ABPP to identify secreted bacterial and host serine hydrolases that are active in animals infected with the cholera pathogen Vibrio cholerae. Four V. cholerae proteases were consistently active in infected rabbits, and one, VC0157 (renamed IvaP), was also active in human choleric stool. Inactivation of IvaP influenced the activity of other secreted V. cholerae and rabbit enzymes in vivo, and genetic disruption of all four proteases increased the abundance of intelectin, an intestinal lectin, and its binding to V. cholerae in infected rabbits. Intelectin also bound to other enteric bacterial pathogens, suggesting that it may constitute a previously unrecognized mechanism of bacterial surveillance in the intestine that is inhibited by pathogen-secreted proteases. Our work demonstrates the power of activity-based proteomics to reveal host-pathogen enzymatic dialog in an animal model of infection. PMID:26900865

  1. Graphical programming of telerobotic tasks

    With a goal of producing faster, safer, and cheaper technologies for nuclear waste cleanup, Sandia is actively developing and extending intelligent systems technologies. Graphical Programming is a key technology for robotic waste cleanup that Sandia is developing for this goal. This paper describes Sancho, Sandia most advanced Graphical Programming supervisory software. Sancho, now operational on several robot systems, incorporates all of Sandia's recent advances in supervisory control. Sancho, developed to rapidly apply Graphical Programming on a diverse set of robot systems, uses a general set of tools to implement task and operational behavior. Sancho can be rapidly reconfigured for new tasks and operations without modifying the supervisory code. Other innovations include task-based interfaces, event-based sequencing, and sophisticated GUI design. These innovations have resulted in robot control programs and approaches that are easier and safer to use than teleoperation, off-line programming, or full automation

  2. Intelligent Computer Graphics 2012

    Miaoulis, Georgios

    2013-01-01

    In Computer Graphics, the use of intelligent techniques started more recently than in other research areas. However, during these last two decades, the use of intelligent Computer Graphics techniques is growing up year after year and more and more interesting techniques are presented in this area.   The purpose of this volume is to present current work of the Intelligent Computer Graphics community, a community growing up year after year. This volume is a kind of continuation of the previously published Springer volumes “Artificial Intelligence Techniques for Computer Graphics” (2008), “Intelligent Computer Graphics 2009” (2009), “Intelligent Computer Graphics 2010” (2010) and “Intelligent Computer Graphics 2011” (2011).   Usually, this kind of volume contains, every year, selected extended papers from the corresponding 3IA Conference of the year. However, the current volume is made from directly reviewed and selected papers, submitted for publication in the volume “Intelligent Computer Gr...

  3. Plasma renin activity profile in normal and hypertensive Filipinos

    To establish a base line profile of plasma renin activity in normotensive and hypertensive Filipinos, 1.019 cases, 479 males and 540 females with an age range 14 - 89 years (mean - 46 +-20) were studied at the Santo Tomas University Hospital of various life styles from the Metro-Manila area, 248 comprised the normotensive group (male - 122 or 49.2 %, female 126 or 50.8 %) and 771 were hypertensive. Of these, 711 (92.6 %) has essential hypertension and are presented in this report. Plasma Renin Activity was determined by radioimmunoassay using Dainabot Renin-Ricket. Concurrent 24 hr. urine sodium and potassium were determined. Nomograms of plasma renin activity as related to urine sodium excretion were drawn after computerized statistical analysis of data. The normal mean value of plasma renin activity was found to be 1.64 +- 0.81 ng./ml./hr. in the upright position and 1.15 +- .68 ng./ml./hr. in the supine position. Based on the nomogram derived, the values obtained in the 711 cases of essential hypertension were classified into High Renin - 14.3 % Normal Renin - 56.1 % and Low Renin - 29.6 %. This study establishes normal levels of plasma renin activity as well as define and classify same renin activity among hypertensive Filipinos, a useful and practicable guide for treatment and can be of prognostic significance. (author)

  4. Graphical matrices in chemistry

    Nikolić, Sonja; Miličević, Ante; Trinajstić, Nenad

    2005-01-01

    Graphical matrices are presented. Their construction via selected sets of subgraphs and the replacement of subgraphs by numbers representing graph invariants are discussed. The last step of the procedure is applying the method of choice to obtain the desired double invariant from the graphical matrix in the numerical form. It is also pointed out that many so-called special graph-theoretical matrices from the literature are rooted in the corresponding graphical matrices. As examples of double ...

  5. Introduction to Graphical Modelling

    Scutari, Marco

    2010-01-01

    The aim of this chapter is twofold. In the first part we will provide a brief overview of the mathematical and statistical foundations of graphical models, along with their fundamental properties, estimation and basic inference procedures. In particular we will develop Markov networks (also known as Markov random fields) and Bayesian networks, which comprise most past and current literature on graphical models. In the second part we will review some applications of graphical models in systems biology.

  6. Graphical Models with R

    Højsgaard, Søren; Lauritzen, Steffen

    2012-01-01

    Graphical models in their modern form have been around since the late 1970s and appear today in many areas of the sciences. Along with the ongoing developments of graphical models, a number of different graphical modeling software programs have been written over the years. In recent years many of these software developments have taken place within the R community, either in the form of new packages or by providing an R interface to existing software. This book attempts to give the reader a gentle introduction to graphical modeling using R and the main features of some of these packages. In add

  7. Defining Dynamic Graphics by a Graphical Language

    毛其昌; 戴汝为

    1991-01-01

    A graphical language which can be used for defining dynamic picture and applying control actions to it is defined with an expanded attributed grammar.Based on this a system is built for developing the presentation of application data of user interface.This system provides user interface designers with a friendly and high efficient programming environment.

  8. Mathematics for computer graphics

    Vince, John

    2006-01-01

    Helps you understand the mathematical ideas used in computer animation, virtual reality, CAD, and other areas of computer graphics. This work also helps you to rediscover the mathematical techniques required to solve problems and design computer programs for computer graphic applications

  9. Molecular Graphics and Chemistry.

    Weber, Jacques; And Others

    1992-01-01

    Explains molecular graphics, i.e., the application of computer graphics techniques to investigate molecular structure, function, and interaction. Structural models and molecular surfaces are discussed, and a theoretical model that can be used for the evaluation of intermolecular interaction energies for organometallics is described. (45…

  10. Flavonoid profile and antileukemic activity of Coreopsis lanceolata flowers.

    Pardede, Antoni; Mashita, Koharu; Ninomiya, Masayuki; Tanaka, Kaori; Koketsu, Mamoru

    2016-06-15

    Coreopsis lanceolata is a perennial plant belonging to the Asteraceae family. In this study, flavonoid profile and antileukemic potential of yellow flowers of the plant were investigated. The total flavonoid content in EtOAc fraction of the flower methanol extract was found to be 420mg/g and showed the inhibition of cell proliferation and possible induction of apoptosis in human leukemia HL-60 cells. Our phytochemical research led to the isolation of rare flavonoids including a flavanone, chalcones, and aurones; in particular, 4-methoxylanceoletin demonstrated the potent antiproliferative activity. Comparison with other Asteraceaeous flowers by UPLC-MS analysis indicated that the isolates are characteristic constituents of C. lanceolata. PMID:27155901

  11. Tea and herbal infusions: Their antioxidant activity and phenolic profile

    Tea and herbal infusions have been studied for their polyphenolic content, antioxidant activity and phenolic profile. The total phenolics recovered by ethyl acetate from the water extract, were determined by the Folin-Ciocalteu procedure and ranged from 88.1 ± 0.42 (Greek mountain tea) to 1216 ± 32.0 mg (Chinese green tea) GAE (Gallic acid equivalents)/cup. The antioxidant activity was evaluated by two methods, DPPH and chemiluminescence assays, using Trolox and quercetin as standards. The EC50 of herbal extracts ranged from 0.151 ± 0.002 mg extract/mg DPPH (0.38 quercetin equivalents and 0.57 Trolox equivalents), for Chinese green tea, to 0.77 ± 0.012 mg extract/mg DPPH (0.08 quercetin equivalents and 0.13 Trolox equivalents), for Greek mountain tea. Chemiluminescence assay results showed that the IC50 ranged from 0.17 ± 3.4 x 103 lg extract/ml of the final solution in the measuring cell (1.89 quercetin and 5.89 Trolox equivalents) for Chinese green tea, to 1.10 ± 1.86 x 102 g extract/ml of the final solution in the measuring cell (0.29 quercetin and 0.90 Trolox equivalents) for Greek mountain tea. The phenolic profile in the herbal infusions was investigated by LC-DAD-MS in the positive electrospray ionization (ESI) mode. About 60 different flavo- noids, phenolic acids and their derivatives have been identified. (author)

  12. Perception in statistical graphics

    VanderPlas, Susan Ruth

    There has been quite a bit of research on statistical graphics and visualization, generally focused on new types of graphics, new software to create graphics, interactivity, and usability studies. Our ability to interpret and use statistical graphics hinges on the interface between the graph itself and the brain that perceives and interprets it, and there is substantially less research on the interplay between graph, eye, brain, and mind than is sufficient to understand the nature of these relationships. The goal of the work presented here is to further explore the interplay between a static graph, the translation of that graph from paper to mental representation (the journey from eye to brain), and the mental processes that operate on that graph once it is transferred into memory (mind). Understanding the perception of statistical graphics should allow researchers to create more effective graphs which produce fewer distortions and viewer errors while reducing the cognitive load necessary to understand the information presented in the graph. Taken together, these experiments should lay a foundation for exploring the perception of statistical graphics. There has been considerable research into the accuracy of numerical judgments viewers make from graphs, and these studies are useful, but it is more effective to understand how errors in these judgments occur so that the root cause of the error can be addressed directly. Understanding how visual reasoning relates to the ability to make judgments from graphs allows us to tailor graphics to particular target audiences. In addition, understanding the hierarchy of salient features in statistical graphics allows us to clearly communicate the important message from data or statistical models by constructing graphics which are designed specifically for the perceptual system.

  13. Chemical profiling of Centella asiatica under different extraction solvents and its antibacterial activity, antioxidant activity

    Supawan Rattanakom; Patchanee Yasurin

    2015-01-01

    Centella asiatica (L) urban, synonym Hydrocotyle asiatica, is found almost all over the world. This plant is famous in Ayurvedic medicine and used in the management of central nervous system, skin and gastrointestinal disorder. Thus this research had been done to evaluate the effect of solvent extraction (Ethanol, Chloroform and Hexane) of C. asiatica on chemical profile, antioxidant activity and antibacterial activity against some foodborne pathogens. The result showed that all solvents (et...

  14. Bayesian Graphical Models

    Jensen, Finn Verner; Nielsen, Thomas Dyhre

    2016-01-01

    Mathematically, a Bayesian graphical model is a compact representation of the joint probability distribution for a set of variables. The most frequently used type of Bayesian graphical models are Bayesian networks. The structural part of a Bayesian graphical model is a graph consisting of nodes and...... largely due to the availability of efficient inference algorithms for answering probabilistic queries about the states of the variables in the network. Furthermore, to support the construction of Bayesian network models, learning algorithms are also available. We give an overview of the Bayesian network...

  15. Sparse Nonparametric Graphical Models

    Lafferty, John; Wasserman, Larry

    2012-01-01

    We present some nonparametric methods for graphical modeling. In the discrete case, where the data are binary or drawn from a finite alphabet, Markov random fields are already essentially nonparametric, since the cliques can take only a finite number of values. Continuous data are different. The Gaussian graphical model is the standard parametric model for continuous data, but it makes distributional assumptions that are often unrealistic. We discuss two approaches to building more flexible graphical models. One allows arbitrary graphs and a nonparametric extension of the Gaussian; the other uses kernel density estimation and restricts the graphs to trees and forests. Examples of both methods are presented. We also discuss possible future research directions for nonparametric graphical modeling.

  16. Digital Raster Graphics

    U.S. Geological Survey, Department of the Interior — A digital raster graphic (DRG) is a scanned image of a U.S. Geological Survey (USGS) topographic map. The scanned image includes all map collar information. The...

  17. Lifestyle profile assessment in active and non-active hypertensive women

    N. R. Cavichia

    2016-05-01

    Full Text Available The present study aimed to evaluate the lifestyle´s profile of 30 hypertensive women practitioners and nonpractitioners of physical activity in the city of Sinop/MT. We used the questionnaire Profile of Single Lifestyle (PSL consists of three issues of the components of Nutrition (N, Physical Activity (PA, Preventive Behavior (PB, Social Networking (SN and Stress Management (SM with scores ranging from 0 to 3 points and score calculated by the sum of questions divided by the number of questions. The data were analyzed statistically with a significance of 5%. The average of the active components of PSL (N = 2,07, PA = 2,04, PB = 2,18, SN = 2,38 and SM = 2,42 and average overall score of 2,16 inactive (N = 1,73, AF = 1,33, PB = 2,40, RS = 2,02 and SN = 2,09 and average score 1,86. In the comparison between groups all components were significant different. It was concluded that the profile of the active lifestyle of hypertensive women have significantly higher values than non-active women

  18. Graphical Potential Games

    Ortiz, Luis E.

    2015-01-01

    Potential games, originally introduced in the early 1990's by Lloyd Shapley, the 2012 Nobel Laureate in Economics, and his colleague Dov Monderer, are a very important class of models in game theory. They have special properties such as the existence of Nash equilibria in pure strategies. This note introduces graphical versions of potential games. Special cases of graphical potential games have already found applicability in many areas of science and engineering beyond economics, including ar...

  19. Computation and graphics in mathematical research

    Hoffman, D.A.; Spruck, J.

    1992-08-13

    This report discusses: The description of the GANG Project and results for prior research; the center for geometry, analysis, numerics and graphics; description of GANG Laboratory; software development at GANG; and mathematical and scientific research activities.

  20. The graphics future in scientific applications

    Computer graphics methods and tools are being used to a great extent in scientific research. The future development in this area will be influenced both by new hardware developments and by software advances. On the hardware sector, the development of the raster technology will lead to the increased use of colour workstations with more local processing power. Colour hardcopy devices for creating plots, slides, or movies will be available at a lower price than today. The first real 3D-workstations appear on the marketplace. One of the main activities on the software sector is the standardization of computer graphics systems, graphical files, and device interfaces. This will lead to more portable graphical application programs and to a common base for computer graphics education. (orig.)

  1. Graphic arts color standards update: 1998

    McDowell, David Q.

    1998-01-01

    Graphic arts related color standards activities are being pursued by ISO Technical Committee 130 (TC130) Graphic technology, and ANSI Committee CGATS (Committee for Graphic Arts Technologies Standards). The content and application of the existing graphic arts color related standards are summarized. These are focused primarily on issues of metrology, color characterization targets, and reference images. The ongoing work has grown out of the need to understand the applicability of color management in the graphic arts work flow and the associated meaning of CMYK data. This has resulted in a growing understanding that, through definition and characterization of the output printing process, CMYK data can be effectively 'device independent,' although possibly not gamut independent. The ongoing work relating to the definition and characterization of various output printing process is also summarized.

  2. Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes.

    Xu, Hao; Majmudar, Jaimeen D; Davda, Dahvid; Ghanakota, Phani; Kim, Ki H; Carlson, Heather A; Showalter, Hollis D; Martin, Brent R; Amidon, Gordon L

    2015-09-01

    Understanding the mechanistic basis of prodrug delivery and activation is critical for establishing species-specific prodrug sensitivities necessary for evaluating preclinical animal models and potential drug-drug interactions. Despite significant adoption of prodrug methodologies for enhanced pharmacokinetics, functional annotation of prodrug activating enzymes is laborious and often unaddressed. Activity-based protein profiling (ABPP) describes an emerging chemoproteomic approach to assay active site occupancy within a mechanistically similar enzyme class in native proteomes. The serine hydrolase enzyme family is broadly reactive with reporter-linked fluorophosphonates, which have shown to provide a mechanism-based covalent labeling strategy to assay the activation state and active site occupancy of cellular serine amidases, esterases, and thioesterases. Here we describe a modified ABPP approach using direct substrate competition to identify activating enzymes for an ethyl ester prodrug, the influenza neuraminidase inhibitor oseltamivir. Substrate-competitive ABPP analysis identified carboxylesterase 1 (CES1) as an oseltamivir-activating enzyme in intestinal cell homogenates. Saturating concentrations of oseltamivir lead to a four-fold reduction in the observed rate constant for CES1 inactivation by fluorophosphonates. WWL50, a reported carbamate inhibitor of mouse CES1, blocked oseltamivir hydrolysis activity in human cell homogenates, confirming CES1 is the primary prodrug activating enzyme for oseltamivir in human liver and intestinal cell lines. The related carbamate inhibitor WWL79 inhibited mouse but not human CES1, providing a series of probes for analyzing prodrug activation mechanisms in different preclinical models. Overall, we present a substrate-competitive activity-based profiling approach for broadly surveying candidate prodrug hydrolyzing enzymes and outline the kinetic parameters for activating enzyme discovery, ester prodrug design, and

  3. Substrate-competitive activity-based profiling of ester prodrug activating enzymes

    Xu, Hao; Majmudar, Jaimeen D.; Davda, Dahvid; Ghanakota, Phani; Kim, Ki H.; Carlson, Heather A.; Showalter, Hollis D.; Martin, Brent R.; Amidon, Gordon L.

    2015-01-01

    Understanding the mechanistic basis of prodrug delivery and activation is critical for establishing species-specific prodrug sensitivities necessary for evaluating pre-clinical animal models and potential drug-drug interactions. Despite significant adoption of prodrug methodologies for enhanced pharmacokinetics, functional annotation of prodrug activating enzymes is laborious and often unaddressed. Activity-based protein profiling (ABPP) describes an emerging chemoproteomic approach to assay active site occupancy within a mechanistically similar enzyme class in native proteomes. The serine hydrolase enzyme family is broadly reactive with reporter-linked fluorophosphonates, which have shown to provide a mechanism-based covalent labeling strategy to assay the activation state and active site occupancy of cellular serine amidases, esterases, and thioesterases. Here we describe a modified ABPP approach using direct substrate competition to identify activating enzymes for an ethyl ester prodrug, the influenza neuraminidase inhibitor oseltamivir. Substrate-competitive ABPP analysis identified carboxylesterase 1 (CES1) as an oseltamivir-activating enzyme in intestinal cell homogenates. Saturating concentrations of oseltamivir lead to a 4-fold reduction in the observed rate constant for CES1 inactivation by fluorophosphonates. WWL50, a reported carbamate inhibitor of mouse CES1, blocked oseltamivir hydrolysis activity in human cell homogenates, confirming CES1 is the primary prodrug activating enzyme for oseltamivir in human liver and intestinal cell lines. The related carbamate inhibitor WWL79 inhibited mouse, but not human CES1, providing a series of probes for analyzing prodrug activation mechanisms in different preclinical models. Overall, we present a substrate-competitive activity-based profiling approach for broadly surveying candidate prodrug hydrolyzing enzymes and outline the kinetic parameters for activating enzyme discovery, ester prodrug design and preclinical

  4. Graphic Conversation #1, #2, #3

    Harkins, Mike

    2008-01-01

    Exhibited at New Views 2: conversations and dialogues in graphic design: an international symposium defining graphic design for the future. London: College of Communication / Melbourne, Australia: Melbourne Museum

  5. Detecting actively translated open reading frames in ribosome profiling data.

    Calviello, Lorenzo; Mukherjee, Neelanjan; Wyler, Emanuel; Zauber, Henrik; Hirsekorn, Antje; Selbach, Matthias; Landthaler, Markus; Obermayer, Benedikt; Ohler, Uwe

    2016-02-01

    RNA-sequencing protocols can quantify gene expression regulation from transcription to protein synthesis. Ribosome profiling (Ribo-seq) maps the positions of translating ribosomes over the entire transcriptome. We have developed RiboTaper (available at https://ohlerlab.mdc-berlin.de/software/), a rigorous statistical approach that identifies translated regions on the basis of the characteristic three-nucleotide periodicity of Ribo-seq data. We used RiboTaper with deep Ribo-seq data from HEK293 cells to derive an extensive map of translation that covered open reading frame (ORF) annotations for more than 11,000 protein-coding genes. We also found distinct ribosomal signatures for several hundred upstream ORFs and ORFs in annotated noncoding genes (ncORFs). Mass spectrometry data confirmed that RiboTaper achieved excellent coverage of the cellular proteome. Although dozens of novel peptide products were validated in this manner, few of the currently annotated long noncoding RNAs appeared to encode stable polypeptides. RiboTaper is a powerful method for comprehensive de novo identification of actively used ORFs from Ribo-seq data. PMID:26657557

  6. Illustrating the Effect of pH on Enzyme Activity Using Gibbs Energy Profiles

    Bearne, Stephen L.

    2014-01-01

    Gibbs energy profiles provide students with a visual representation of the energy changes that occur during enzyme catalysis, making such profiles useful as teaching and learning tools. Traditional kinetic topics, such as the effect of pH on enzyme activity, are often not discussed in terms of Gibbs energy profiles. Herein, the symbolism of Gibbs…

  7. Graphic Cigarette Warnings May Target Brain's 'Quit Centers'

    ... scans, the smokers were shown non-graphic and graphic pictures used on cigarette pack warning labels. For example, one image included an open mouth with rotten teeth and a tumor on the lower lip. The images were accompanied by ... the graphic pictures triggered activity in areas of the brain ...

  8. Introduction to regression graphics

    Cook, R Dennis

    2009-01-01

    Covers the use of dynamic and interactive computer graphics in linear regression analysis, focusing on analytical graphics. Features new techniques like plot rotation. The authors have composed their own regression code, using Xlisp-Stat language called R-code, which is a nearly complete system for linear regression analysis and can be utilized as the main computer program in a linear regression course. The accompanying disks, for both Macintosh and Windows computers, contain the R-code and Xlisp-Stat. An Instructor's Manual presenting detailed solutions to all the problems in the book is ava

  9. Graphical recipe automation

    Kristinn Árdal 1990

    2015-01-01

    Graphical recipes are a way of representing cooking instructions and we wanted to make the process of making them automatic. The software would be able to read in a recipe text, ingredient list and instructions, and output a graphical recipe. To extract information out of written text Natural Language Processing was used. We ran into some trouble with part of speech tagging the text and in the end trained our own tagger with an accuracy of 97%. The software does not generate perfect graphi...

  10. Open|SpeedShop Graphical User Interface Technology Project

    National Aeronautics and Space Administration — We propose to create a new graphical user interface (GUI) for an existing parallel application performance and profiling tool, Open|SpeedShop. The current GUI has...

  11. TEK11 graphics user's guide

    The TEK11 graphics library was written for use on PDP-11 minicomputers running the RT-11 operating system to drive Tektronix 4010 graphics display terminals. Library subroutines are coded in FORTRAN and assembly language. The library includes routines to draw axes, either linear or semilog, to plot data in terms of logical values without first scaling to screen coordinates, to label graphs, and to plot in a maximum of four regions on the screen. Modes of plotting may be point plot with any character at the point, vector plot, or bar plot. Two features, automatic scaling and windowing, permit the researcher to use computer graphics without spending time first to learn about scaling or ''Tek points'' and preparing long parameter lists for subroutines. Regions on the screen are defined by specifying minima and maxima logical coordinates, i.e., 0K or milliseconds, and a region number. After definition, a region may be activated for plotting by calling REGN with the region number as an argument

  12. Mathematical structures for computer graphics

    Janke, Steven J

    2014-01-01

    A comprehensive exploration of the mathematics behind the modeling and rendering of computer graphics scenes Mathematical Structures for Computer Graphics presents an accessible and intuitive approach to the mathematical ideas and techniques necessary for two- and three-dimensional computer graphics. Focusing on the significant mathematical results, the book establishes key algorithms used to build complex graphics scenes. Written for readers with various levels of mathematical background, the book develops a solid foundation for graphics techniques and fills in relevant grap

  13. Pyrethroid Activity-Based Probes for Profiling Cytochrome P450 Activities Associated with Insecticide Interactions

    Ismail, Hanafy M.; O' Neill, Paul M.; Hong, David; Finn, Robert; Henderson, Colin; Wright, Aaron T.; Cravatt, Benjamin; Hemingway, Janet; Paine, Mark J.

    2014-01-18

    Pyrethroid insecticides are used to control a diverse spectrum of diseases spread by arthropods. We have developed a suite of pyrethroid mimetic activity based probes (PyABPs) to selectively label and identify P450s associated with pyrethroid metabolism. The probes were screened against pyrethroid metabolizing and non-metabolizing mosquito P450s, as well as rodent microsomes to measure labeling specificity, plus CPR and b5 knockout mouse livers to validate P450 activation and establish the role for b5 in probe activation. Using a deltamethrin mimetic PyABP we were able to profile active enzymes in rat liver microsomes and identify pyrethroid metabolizing enzymes in the target tissue. The most reactive enzyme was a P450, CYP2C11, which is known to metabolize deltamethrin. Furthermore, several other pyrethroid metabolizers were identified (CYPs 2C6, 3A4, 2C13 and 2D1) along with related detoxification enzymes, notably UDP-g’s 2B1 - 5, suggesting a network of associated pyrethroid metabolizing enzymes, or ‘pyrethrome’. Considering the central role that P450s play in metabolizing insecticides, we anticipate that PyABPs will aid the identification and profiling of P450s associated with insecticide pharmacology in a wide range of species, improving understanding of P450-insecticide interactions and aiding the development of new tools for disease control.

  14. Printer Graphics Package

    Blanchard, D. C.

    1986-01-01

    Printer Graphics Package (PGP) is tool for making two-dimensional symbolic plots on line printer. PGP created to support development of Heads-Up Display (HUD) simulation. Standard symbols defined with HUD in mind. Available symbols include circle, triangle, quadrangle, window, line, numbers, and text. Additional symbols easily added or built up from available symbols.

  15. Graphic Novels: A Roundup.

    Kan, Katherine L.

    1994-01-01

    Reviews graphic novels for young adults, including five titles from "The Adventures of Tintin," a French series that often uses ethnic and racial stereotypes which reflect the time in which they were published, and "Wolverine," a Marvel comic character adventure. (Contains six references.) (LRW)

  16. Graphics Conference Calendar

    2004-01-01

    1. The 13th International Conference in Central Europe on Computer Graphics, Visualization and Computer Vision'2005, University of West Bohemia, Campus-Bory Plzen (very close to Prague, the capital of the Czech Republic)Czech Republic, January 31 - February 4, 2005. http://wscg.zcu.cz, skala@kiv.zcu.cz

  17. The graphics future in scientific applications-trends and developments in computer graphics

    Enderle, G

    1982-01-01

    Computer graphics methods and tools are being used to a great extent in scientific research. The future development in this area will be influenced both by new hardware developments and by software advances. On the hardware sector, the development of the raster technology will lead to the increased use of colour workstations with more local processing power. Colour hardcopy devices for creating plots, slides, or movies will be available at a lower price than today. The first real 3D-workstations will appear on the marketplace. One of the main activities on the software sector is the standardization of computer graphics systems, graphical files, and device interfaces. This will lead to more portable graphical application programs and to a common base for computer graphics education.

  18. Graphics gems V (Macintosh version)

    Paeth, Alan W

    1995-01-01

    Graphics Gems V is the newest volume in The Graphics Gems Series. It is intended to provide the graphics community with a set of practical tools for implementing new ideas and techniques, and to offer working solutions to real programming problems. These tools are written by a wide variety of graphics programmers from industry, academia, and research. The books in the series have become essential, time-saving tools for many programmers.Latest collection of graphics tips in The Graphics Gems Series written by the leading programmers in the field.Contains over 50 new gems displaying some of t

  19. Topographic Digital Raster Graphics - USGS DIGITAL RASTER GRAPHICS

    NSGIC GIS Inventory (aka Ramona) — USGS Topographic Digital Raster Graphics downloaded from LABINS (http://data.labins.org/2003/MappingData/drg/drg_stpl83.cfm). A digital raster graphic (DRG) is a...

  20. Hydrodynamics on graphic cards

    In the field of high-energetic nucleus-nucleus collisions at RHIC and LHC ideal and dissipative relativistic hydrodynamics is used to calculate the evolution of hot and dense QCD matter. A large body of current numerical tools employs relativistic hydrodynamics in various facets. The acceleration of relativistic hydrodynamics using graphic cards (GPUs) is therefore of highest relevance to this fields. The results reported here are based on the Sharp And Smooth Transport Algorithm SHASTA, which is employed in many hydrodynamical models and hybrid simulation packages, e.g. the Ultrarelativistic Quantum Molecular Dynamics model (UrQMD). We have redesigned the SHASTA using the OpenCL computing framework to work on accelerators like graphic processing units (GPUs) as well as on multi-core processors. With the redesign of the algorithm the hydrodynamic calculations have been accelerated by a factor 160 allowing for event-by-event calculations and better statistics in hybrid calculations.

  1. Graphic Grown Up

    Kim, Ann

    2009-01-01

    It's no secret that children and YAs are clued in to graphic novels (GNs) and that comics-loving adults are positively giddy that this format is getting the recognition it deserves. Still, there is a whole swath of library card-carrying grown-up readers out there with no idea where to start. Splashy movies such as "300" and "Spider-Man" and their…

  2. Graphics Gems Revisited

    Guy, Stéphane; Soler, Cyril

    2004-01-01

    We present an algorithm for rendering faceted colored gemstones in real time, using graphics hardware. Beyond the technical challenge of handling the complex behavior of light in such objects, a real time high quality rendering of gemstones has direct applications in the field of jewelry prototyping, which has now become a standard practice for replacing tedious (and less interactive) wax carving methods. Our solution is based on a number of controlled approximations of the physical phenomena...

  3. Reading in public libraries: space, reading activities and user profiles

    Sequeiros, Paula

    2013-01-01

    This single case research was developed within a public library in Porto, Portugal, Biblioteca Municipal Almeida Garrett. Its main objective was to understand how public library readers interact with space, the Internet technology and reading resources, and how these interactions shape the representations of what a public library is. This case was chosen because the library has a recent and renowned building, high reader use levels, and Internet access. The design of user profiles was an i...

  4. RELATIONSHIPS BETWEEN PHYSICAL EDUCATION STUDENTS' MOTIVATIONAL PROFILES, ENJOYMENT, STATE ANXIETY, AND SELF-REPORTED PHYSICAL ACTIVITY

    Sami Yli-Piipari

    2009-09-01

    Full Text Available The purpose of this study was to analyze motivational profiles based on the self-determination theory (Deci and Ryan, 2000 and how these profiles are related to physical education students' enjoyment, state anxiety, and physical activity. The participants, 429 sixth grade students (girls = 216; boys = 213 completed SMS, Sport Enjoyment Scale, PESAS, and Physical Activity Scale. Cluster analyses identified two motivational profiles: 1 the "High motivation profile", in which the students had high intrinsic and extrinsic motivation, and low levels of amotivation, and 2 the "Low motivation profile", in which the students had low intrinsic and extrinsic motivation, and low levels of amotivation. The students in the first cluster enjoyed physical education more and were physically more active. The results revealed that students may be motivated towards physical education lessons both intrinsically and extrinsically, and still experience enjoyment in physical education.

  5. A Codesign Case Study in Computer Graphics

    Brage, Jens P.; Madsen, Jan

    1994-01-01

    The paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based on information obtained from software profiling and the resulting design is validated through cosimulation. A locally developed interface model, Merlin, is used as the basis for co-simulation. The ac...

  6. Critical frameworks for graphic design: graphic design and visual culture

    Dauppe, Michele-Anne

    2011-01-01

    The paper considers an approach to the study of graphic design which addresses the expanding nature of graphic design in the 21st century and the purposeful application of theory to the subject of graphic design. In recent years graphic design has expanded its domain from the world of print culture (e.g. books, posters) into what is sometimes called screen culture. Everything from a mobile phone to a display in an airport lounge to the A.T.M. carries graphic design. It has become ever more ub...

  7. Selecting Mangas and Graphic Novels

    Nylund, Carol

    2007-01-01

    The decision to add graphic novels, and particularly the Japanese styled called manga, was one the author has debated for a long time. In this article, the author shares her experience when she purchased graphic novels and mangas to add to her library collection. She shares how graphic novels and mangas have revitalized the library.

  8. Codesign Analysis of a Computer Graphics Application

    Madsen, Jan; Brage, Jens P.

    1996-01-01

    This paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based...... on information obtained from software profiling and the resulting design is validated through cosimulation. The achieved speed-up is estimated based on an analysis of profiling information from different sets of input data and various architectural options....

  9. A Codesign Case Study in Computer Graphics

    Brage, Jens P.; Madsen, Jan

    1994-01-01

    The paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based...... on information obtained from software profiling and the resulting design is validated through cosimulation. A locally developed interface model, Merlin, is used as the basis for co-simulation. The achieved speed-up is estimated based on an analysis of profile information....

  10. Codesign Analysis of a Computer Graphics Application

    Madsen, Jan; Brage, Jens P.

    This paper describes a codesign case study where a computer graphics application is examined with the intention to speed up its execution. The application is specified as a C program, and is characterized by the lack of a simple compute-intensive kernel. The hardware/software partitioning is based...... on information obtained from software profiling and the resulting design is validated through cosimulation. The achieved speed-up is estimated based on an analysis of profiling information from different sets of input data and various architectural options....

  11. Multicomponent He I 10 830 Å profiles in an active filament

    Sasso, C.; Lagg, A.; Solanki, S. K.

    2011-02-01

    Aims: We present new spectropolarimetric observations of the chromospheric He i 10 830 Å multiplet observed in a filament during its phase of activity. Methods: The data were recorded with the new Tenerife Infrared Polarimeter (TIP-II) at the German Vacuum Tower Telescope (VTT) on 2005 May 18. We inverted the He Stokes profiles using multiple atmospheric components. Results: The observed He Stokes profiles display a remarkably wide variety of shapes. Most of the profiles show very broad Stokes I absorptions and complex and spatially variable Stokes V signatures. The inversion of the profiles shows evidence of different atmospheric blue- and redshifted components of the He i lines within the resolution element (~1 arcsec), with supersonic velocities of up to ~100 km s-1. Up to five different atmospheric components are found in the same profile. We show that even these complex profiles can be reliably inverted.

  12. The DNA methylation profile of activated human natural killer cells.

    Wiencke, John K; Butler, Rondi; Hsuang, George; Eliot, Melissa; Kim, Stephanie; Sepulveda, Manuel A; Siegel, Derick; Houseman, E Andres; Kelsey, Karl T

    2016-05-01

    Natural killer (NK) cells are now recognized to exhibit characteristics akin to cells of the adaptive immune system. The generation of adaptive memory is linked to epigenetic reprogramming including alterations in DNA methylation. The study herein found reproducible genome wide DNA methylation changes associated with human NK cell activation. Activation led predominately to CpG hypomethylation (81% of significant loci). Bioinformatics analysis confirmed that non-coding and gene-associated differentially methylated sites (DMS) are enriched for immune related functions (i.e., immune cell activation). Known DNA methylation-regulated immune loci were also identified in activated NK cells (e.g., TNFA, LTA, IL13, CSF2). Twenty-one loci were designated high priority and further investigated as potential markers of NK activation. BHLHE40 was identified as a viable candidate for which a droplet digital PCR assay for demethylation was developed. The assay revealed high demethylation in activated NK cells and low demethylation in naïve NK, T- and B-cells. We conclude the NK cell methylome is plastic with potential for remodeling. The differentially methylated region signature of activated NKs revealed similarities with T cell activation, but also provided unique biomarker candidates of NK activation, which could be useful in epigenome-wide association studies to interrogate the role of NK subtypes in global methylation changes associated with exposures and/or disease states. PMID:26967308

  13. Evaluation of Kinase Activity Profiling Using Chemical Proteomics.

    Ruprecht, Benjamin; Zecha, Jana; Heinzlmeir, Stephanie; Médard, Guillaume; Lemeer, Simone; Kuster, Bernhard

    2015-12-18

    Protein kinases are important mediators of intracellular signaling and are reversibly activated by phosphorylation. Immobilized kinase inhibitors can be used to enrich these often low-abundance proteins, to identify targets of kinase inhibitors, or to probe their selectivity. It has been suggested that the binding of kinases to affinity beads reflects a kinase's activation status, a concept that is under considerable debate. To assess the merits of the idea, we performed a series of experiments including quantitative phosphoproteomics and purification of kinases by single or mixed affinity matrices from signaling activated or resting cancer cells. The data show that mixed affinity beads largely bind kinases independent of their activation status, and experiments using individual immobilized kinase inhibitors show mixed results in terms of preference for binding the active or inactive conformation. Taken together, activity- or conformation-dependent binding to such affinity resins depends (i) on the kinase, (ii) on the affinity probe, and (iii) on the activation status of the lysate or cell. As a result, great caution should be exercised when inferring kinase activity from such binding data. The results also suggest that assaying kinase activity using binding data is restricted to a limited number of well-chosen cases. PMID:26378887

  14. Deterministic Graphical Games Revisited

    Andersson, Klas Olof Daniel; Hansen, Kristoffer Arnsfelt; Miltersen, Peter Bro;

    2012-01-01

    as retrograde analysis, have been rediscovered independently. We then revisit Washburn’s deterministic graphical games (DGGs), a natural generalization of chess-like games to arbitrary zero-sum payoffs. We study the complexity of solving DGGs and obtain an almost-linear time comparison......Starting from Zermelo’s classical formal treatment of chess, we trace through history the analysis of two-player win/lose/draw games with perfect information and potentially infinite play. Such chess-like games have appeared in many different research communities, and methods for solving them, such...

  15. Graphics Gems III IBM version

    Kirk, David

    1994-01-01

    This sequel to Graphics Gems (Academic Press, 1990), and Graphics Gems II (Academic Press, 1991) is a practical collection of computer graphics programming tools and techniques. Graphics Gems III contains a larger percentage of gems related to modeling and rendering, particularly lighting and shading. This new edition also covers image processing, numerical and programming techniques, modeling and transformations, 2D and 3D geometry and algorithms,ray tracing and radiosity, rendering, and more clever new tools and tricks for graphics programming. Volume III also includes a

  16. Direct and two-step activity-based profiling of proteases and glycosidases

    Willems, Lianne Irene

    2014-01-01

    Activity-based protein profiling provides a powerful approach for the monitoring of active enzyme populations in complex biological samples by making use of activity-based probes (ABPs), chemical probes that are designed to bind specifically to the active site of an enzyme (family). The research described in this thesis concerns two main topics. First, new techniques are developed for the two-step labeling of enzymatic activity, a strategy that involves the targeting of enzymes with an ABP fo...

  17. ANTIOXIDANT ACTIVITIES AND PHENOLIC PROFILE OF SIX MOROCCAN SELECTED HERBS

    Madiha Bichra

    2013-02-01

    Full Text Available The present work evaluated the antioxidant capacity of six plants commonly used in traditional Moroccan medicine. The antioxidant capacity was estimated by DPPH test, ferrous ion chelating activity and ABTS test. As results, the highest antioxidant activities were found in Mentha suaveolens, Salvia officinalis and Mentha viridis. Different species showed significant differences in their total phenolic content (TPC. The highest level of phenolics was found in Salvia officinalis and the lowest in Pelargonium roseum. Linear correlation was found between TPC, especially the non-flavonoid content (NFC and the antioxidant activity. Qualitative and quantitative analyzes of major phenolics by reverse-phase high-performance liquid chromatography (RP-HPLC were also performed. On the basis of the obtained results, these studied medicinal herbs were found to serve as a potential source of natural antioxidants due to their richness in phenolic compounds and marked antioxidant activity.

  18. Molecular profiling of activated neurons by phosphorylated ribosome capture.

    Knight, Zachary A; Tan, Keith; Birsoy, Kivanc; Schmidt, Sarah; Garrison, Jennifer L; Wysocki, Robert W; Emiliano, Ana; Ekstrand, Mats I; Friedman, Jeffrey M

    2012-11-21

    The mammalian brain is composed of thousands of interacting neural cell types. Systematic approaches to establish the molecular identity of functional populations of neurons would advance our understanding of neural mechanisms controlling behavior. Here, we show that ribosomal protein S6, a structural component of the ribosome, becomes phosphorylated in neurons activated by a wide range of stimuli. We show that these phosphorylated ribosomes can be captured from mouse brain homogenates, thereby enriching directly for the mRNAs expressed in discrete subpopulations of activated cells. We use this approach to identify neurons in the hypothalamus regulated by changes in salt balance or food availability. We show that galanin neurons are activated by fasting and that prodynorphin neurons restrain food intake during scheduled feeding. These studies identify elements of the neural circuit that controls food intake and illustrate how the activity-dependent capture of cell-type-specific transcripts can elucidate the functional organization of a complex tissue. PMID:23178128

  19. ANTIOXIDANT ACTIVITIES AND PHENOLIC PROFILE OF SIX MOROCCAN SELECTED HERBS

    Madiha Bichra; Cherkaoui El-Modafar; Abdelilah El-Abbassi; Hafida Bouamama; Fatiha Benkhalti

    2013-01-01

    The present work evaluated the antioxidant capacity of six plants commonly used in traditional Moroccan medicine. The antioxidant capacity was estimated by DPPH test, ferrous ion chelating activity and ABTS test. As results, the highest antioxidant activities were found in Mentha suaveolens, Salvia officinalis and Mentha viridis. Different species showed significant differences in their total phenolic content (TPC). The highest level of phenolics was found in Salvia officinalis and the lowest...

  20. Physical activity and physical fitness profiles of South African women

    Smit, Madelein; Strydom, Gert Lukas; Wilders, Cilas Jacobus

    2011-01-01

    The purpose of this study was to determine the leisure time physical activity (LTPA) participation and physical fitness (PF) levels of South African women of the various ethnic groups. Individuals between the ages of 30 and 60 years (=41.0; ±=4.6) who were part of a cross-sectional non-randomized availability population who voluntarily participated, were used in this study. The group that formed part of the physical activity survey included 3273 subjects (Asian =262; black=1357; coloured=239;...

  1. Complement profile and activation mechanisms by different LDL apheresis systems.

    Hovland, Anders; Hardersen, Randolf; Nielsen, Erik Waage; Enebakk, Terje; Christiansen, Dorte; Ludviksen, Judith Krey; Mollnes, Tom Eirik; Lappegård, Knut Tore

    2012-07-01

    Extracorporeal removal of low-density lipoprotein (LDL) cholesterol by means of selective LDL apheresis is indicated in otherwise uncontrolled familial hypercholesterolemia. During blood-biomaterial interaction other constituents than the LDL particles are affected, including the complement system. We set up an ex vivo model in which human whole blood was passed through an LDL apheresis system with one of three different apheresis columns: whole blood adsorption, plasma adsorption and plasma filtration. The concentrations of complement activation products revealed distinctly different patterns of activation and adsorption by the different systems. Evaluated as the final common terminal complement complex (TCC) the whole blood system was inert, in contrast to the plasma systems, which generated substantial and equal amounts of TCC. Initial classical pathway activation was revealed equally for both plasma systems as increases in the C1rs-C1inh complex and C4d. Alternative pathway activation (Bb) was most pronounced for the plasma adsorption system. Although the anaphylatoxins (C3a and C5a) were equally generated by the two plasma separation systems, they were efficiently adsorbed to the plasma adsorption column before the "outlet", whereas they were left free in the plasma in the filtration system. Consequently, during blood-biomaterial interaction in LDL apheresis the complement system is modulated in different manners depending on the device composition. PMID:22373816

  2. Can we be more Graphic about Graphic Design?

    Vienne, Véronique

    2012-01-01

    Can you objectify a subjective notion? This is the question graphic designers must face when they talk about their work. Even though graphic design artifacts are omnipresent in our culture, graphic design is still an exceptionally ill-defined profession. This is one of the reasons design criticism is still a rudimentary discipline. No one knows for sure what is this thing we sometimes call “graphic communication” for lack of a better word–a technique my Webster’s dictionary describes as “the ...

  3. Dysregulation of Macrophage Activation Profiles by Engineered Nanoparticles

    Kodali, Vamsi; Littke, Matthew H.; Tilton, Susan C.; Teeguarden, Justin G.; Shi, Liang; Frevert, Charles W.; Wang, Wei; Pounds, Joel G.; Thrall, Brian D.

    2013-08-27

    Although the potential human health impacts from exposure to engineered nanoparticles (ENPs) are uncertain, past epidemiological studies have established correlations between exposure to ambient air pollution particulates and the incidence of pneumonia and lung infections. Using amorphous silica and superparamagnetic iron oxide (SPIO) as model high production volume ENPs, we examined how macrophage activation by bacterial lipopolysaccharide (LPS) or the lung pathogen Streptococcus pneumoniae is altered by ENP pretreatment. Neither silica nor SPIO treatment elicited direct cytotoxic or pro-inflammatory effects in bone marrow-derived macrophages. However, pretreatment of macrophages with SPIO caused extensive reprogramming of nearly 500 genes regulated in response to LPS challenge, hallmarked by exaggerated activation of oxidative stress response pathways and suppressed activation of both pro- and anti-inflammatory pathways. Silica pretreatment altered regulation of only 67 genes, but there was strong correlation with gene sets affected by SPIO. Macrophages exposed to SPIO displayed a phenotype suggesting an impaired ability to transition from an M1 to M2-like activation state, characterized by suppressed IL-10 induction, enhanced TNFα production, and diminished phagocytic activity toward S. pneumoniae. Studies in macrophages deficient in scavenger receptor A (SR-A) showed SR-A participates in cell uptake of both the ENPs and S. pneumonia and co-regulates the anti-inflammatory IL-10 pathway. Thus, mechanisms for dysregulation of innate immunity exist by virtue that common receptor recognition pathways are used by some ENPs and pathogenic bacteria, although the extent of transcriptional reprogramming of macrophage function depends on the physicochemical properties of the ENP after internalization. Our results also illustrate that biological effects of ENPs may be indirectly manifested only after challenging normal cell function. Finally, nanotoxicology screening

  4. Synthesising Graphical Theories

    Kissinger, Aleks

    2012-01-01

    In recent years, diagrammatic languages have been shown to be a powerful and expressive tool for reasoning about physical, logical, and semantic processes represented as morphisms in a monoidal category. In particular, categorical quantum mechanics, or "Quantum Picturalism", aims to turn concrete features of quantum theory into abstract structural properties, expressed in the form of diagrammatic identities. One way we search for these properties is to start with a concrete model (e.g. a set of linear maps or finite relations) and start composing generators into diagrams and looking for graphical identities. Naively, we could automate this procedure by enumerating all diagrams up to a given size and check for equalities, but this is intractable in practice because it produces far too many equations. Luckily, many of these identities are not primitive, but rather derivable from simpler ones. In 2010, Johansson, Dixon, and Bundy developed a technique called conjecture synthesis for automatically generating conj...

  5. [Hardware for graphics systems].

    Goetz, C

    1991-02-01

    In all personal computer applications, be it for private or professional use, the decision of which "brand" of computer to buy is of central importance. In the USA Apple computers are mainly used in universities, while in Europe computers of the so-called "industry standard" by IBM (or clones thereof) have been increasingly used for many years. Independently of any brand name considerations, the computer components purchased must meet the current (and projected) needs of the user. Graphic capabilities and standards, processor speed, the use of co-processors, as well as input and output devices such as "mouse", printers and scanners are discussed. This overview is meant to serve as a decision aid. Potential users are given a short but detailed summary of current technical features. PMID:2042260

  6. SHORT SURVEY ON GRAPHICAL DATABASE

    Harsha R Vyavahare

    2015-08-01

    Full Text Available This paper explores the features of graph databases and data models. The popularity towards work with graph models and datasets has been increased in the recent decades .Graph database has a number of advantage over the relational database. This paper take a short review on the graph and hyper graph concepts from mathematics so that graph so that we can understand the existing difficulties in the implantation of graph model. From the Past few decades saw hundreds of research contributions their vast research in the DBS field with graph database. However, the research on the existence of general purpose DBS managements and mining that suits for variety of applications is still very much active. The review is done based on the Application of graph model techniques in the database within the framework of graph based approaches with the aim of implementation of different graphical database and tabular database

  7. Application of Computer Graphics to Performance Studies of Missile Warheads

    K. Rama Rao; K.P.S. Murthy; M.R. Patkar

    1991-01-01

    Intercept geometry of target aircraft and missiles play an important role in determining the effectiveness of the warhead. Factors such as fragment spatial distribution profile, damage capabilities, target and missile characteristics have been considered and visualised through computer graphics and optimum intercept intercept angles have been arrived. Computer graphics has proved to be an important tool to enhance perception and conceptual design capabilities in the design environment.

  8. Chilean Prosopis Mesocarp Flour: Phenolic Profiling and Antioxidant Activity

    Guillermo Schmeda-Hirschmann

    2015-04-01

    Full Text Available In South America, the mesocarp flour of Prosopis species plays a prominent role as a food resource in arid areas. The aim of this work was the characterization of the phenolic antioxidants occurring in the pod mesocarp flour of Chilean Prosopis. Samples were collected in the Copiapo, Huasco and Elqui valleys from the north of Chile. The samples of P. chilensis flour exhibited a total phenolic content ranging between 0.82–2.57 g gallic acid equivalents/100 g fresh flour weight. The highest antioxidant activity, measured by the DPPH assay, was observed for samples from the Huasco valley. HPLC-MS/MS analysis allowed the tentative identification of eight anthocyanins and 13 phenolic compounds including flavonol glycosides, C-glycosyl flavones and ellagic acid derivatives. The antioxidant activity and the phenolic composition in the flour suggest that this ancient South American resource may have potential as a functional food.

  9. Chilean prosopis mesocarp flour: phenolic profiling and antioxidant activity.

    Schmeda-Hirschmann, Guillermo; Quispe, Cristina; Soriano, Maria Del Pilar C; Theoduloz, Cristina; Jiménez-Aspée, Felipe; Pérez, Maria Jorgelina; Cuello, Ana Soledad; Isla, Maria Inés

    2015-01-01

    In South America, the mesocarp flour of Prosopis species plays a prominent role as a food resource in arid areas. The aim of this work was the characterization of the phenolic antioxidants occurring in the pod mesocarp flour of Chilean Prosopis. Samples were collected in the Copiapo, Huasco and Elqui valleys from the north of Chile. The samples of P. chilensis flour exhibited a total phenolic content ranging between 0.82-2.57 g gallic acid equivalents/100 g fresh flour weight. The highest antioxidant activity, measured by the DPPH assay, was observed for samples from the Huasco valley. HPLC-MS/MS analysis allowed the tentative identification of eight anthocyanins and 13 phenolic compounds including flavonol glycosides, C-glycosyl flavones and ellagic acid derivatives. The antioxidant activity and the phenolic composition in the flour suggest that this ancient South American resource may have potential as a functional food. PMID:25898415

  10. Molecular Profiling of Activated Neurons by Phosphorylated Ribosome Capture

    Knight, Zachary A.; Tan, Keith; Birsoy, Kivanc; Schmidt, Sarah; Garrison, Jennifer L.; Wysocki, Robert W.; Emiliano, Ana; Ekstrand, Mats I.; Friedman, Jeffrey M.

    2012-01-01

    The mammalian brain is composed of thousands of interacting neural cell types. Systematic approaches to establish the molecular identity of functional populations of neurons would advance our understanding of neural mechanisms controlling behavior. Here, we show that ribosomal protein S6, a structural component of the ribosome, becomes phosphorylated in neurons activated by a wide range of stimuli. We show that these phosphorylated ribosomes can be captured from mouse brain homogenates, there...

  11. Chemicals profiling and antioxidants activities of Acacia seeds

    Ennajeh, Imen; Laajel, Mejda; Khouja, Mohamed-Larbi; Ferchichi, Ali; Nasri, Nizar

    2011-01-01

    This study reported investigations on phytochemical screening and antioxidants activities of seeds from seven Acacia species. Storage proteins and mineral contents were determined. The seed extracts of Acacia species were evaluated for their total phenols, flavonoids, carotenoids contents and total antioxidant capacity assessed by 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. Total protein content ranged from 99.49 (Acacia cyclops...

  12. Integration of rocket turbine design and analysis through computer graphics

    Hsu, Wayne; Boynton, Jim

    1988-01-01

    An interactive approach with engineering computer graphics is used to integrate the design and analysis processes of a rocket engine turbine into a progressive and iterative design procedure. The processes are interconnected through pre- and postprocessors. The graphics are used to generate the blade profiles, their stacking, finite element generation, and analysis presentation through color graphics. Steps of the design process discussed include pitch-line design, axisymmetric hub-to-tip meridional design, and quasi-three-dimensional analysis. The viscous two- and three-dimensional analysis codes are executed after acceptable designs are achieved and estimates of initial losses are confirmed.

  13. Big system: Interactive graphics for the engineer

    Quenneville, C. E.

    1975-01-01

    The BCS Interactive Graphics System (BIG System) approach to graphics was presented, along with several significant engineering applications. The BIG System precompiler, the graphics support library, and the function requirements of graphics applications are discussed. It was concluded that graphics standardization and a device independent code can be developed to assure maximum graphic terminal transferability.

  14. Computer graphics for the mining industry

    1984-01-01

    The following papers were presented: information graphics in the mining industry; role of the personal computer in graphics; the rastergraphics approach; trends in graphics software; raster technology in graphics; computer graphics in mine planning; application of computer graphics in mine fire detection. 3 papers have been abstracted separately.

  15. Graphical models for genetic analyses

    Lauritzen, Steffen Lilholt; Sheehan, Nuala A.

    2003-01-01

    This paper introduces graphical models as a natural environment in which to formulate and solve problems in genetics and related areas. Particular emphasis is given to the relationships among various local computation algorithms which have been developed within the hitherto mostly separate areas of...... graphical models and genetics. The potential of graphical models is explored and illustrated through a number of example applications where the genetic element is substantial or dominating....

  16. Performance Evaluation of Graphics Accelerator

    Vanek, Juraj

    2010-01-01

    This paper deals with possibilities and functions of modern graphic accelerators and with measuring performance under OpenGL interface. Widespread algorithms to render scene in real-time are used. It focuses on how to test every part of accelerator's graphic pipeline as well as measure performance in rendering of advanced effects and theoretical speed at general purpose calculations through graphic processor. This testing is realized by implementing multiple test series and their further eval...

  17. Phenolic Profiles and Antioxidant Activity of Lotus Root Varieties

    Yang Yi

    2016-06-01

    Full Text Available Lotus root attracts increasing attention mainly because of its phenolic compounds known as natural antioxidants. Its thirteen varieties were systematically analyzed on the content, distribution, composition and antioxidant activity of phenolic compounds for a better understanding of this aquatic vegetable. The respective mean contents of total phenolics in their flesh, peel and nodes were 1.81, 4.30 and 7.35 mg gallic acid equivalents (GAE/g fresh weight (FW, and those of total flavonoids were 3.35, 7.69 and 15.58 mg rutin equivalents/g FW. The phenolic composition determined by a high-performance liquid chromatography method varied significantly among varieties and parts. The phenolics of flesh were mainly composed of gallocatechin and catechin; those of peel and node were mainly composed of gallocatechin, gallic acid, catechin and epicatechin. The antioxidant activities of phenolic extracts in increasing order were flesh, peel and node; their mean concentrations for 50% inhibition of 2,2-diphenyl-1-picrylhydrazyl radical were 46.00, 26.43 and 21.72 µg GAE/mL, and their mean values representing ferric reducing antioxidant power were 75.91, 87.66 and 100.43 µg Trolox equivalents/100 µg GAE, respectively. “Zoumayang”, “Baheou”, “No. 5 elian” and “Guixi Fuou” were the hierarchically clustered varieties with relatively higher phenolic content and stronger antioxidant activity as compared with the others. Especially, their nodes and peels are promising sources of antioxidants for human nutrition.

  18. Enzyme activity profiles during fruit development in tomato cultivars and Solanum pennellii

    Steinhauser, Marie-Caroline; Steinhauser, Dirk; Koehl, Karin; Carrari, Fernando; Gibon, Yves; Fernie, Alisdair R.; Stitt, Mark

    2010-01-01

    Enzymes interact to generate metabolic networks. The activities of more than 22 enzymes from central metabolism were profiled during the development of fruit of the modern tomato cultivar Solanum lycopersicum 'M82' and its wild relative Solanum pennellii (LA0716). In S. pennellii, the mature fruit remains green and contains lower sugar and higher organic acid levels. These genotypes are the parents of a widely used near introgression line population. Enzymes were also profiled in a second cul...

  19. Green and roasted mate: phenolic profile and antioxidant activity

    EROL, Nihal Türkmen; Sari, Ferda; ÇALIKOĞLU, Eda; VELİOĞLU, Yakup Sedat

    2009-01-01

    Mate infusions have been recently and frequently used as dietary supplements because of their health effects to prevent atherosclerosis and coronary heart disease and to be antioxidant. The aim of this study was to determine phenolic compounds and antioxidant activities of green mate (GM) and roasted mate (RM) extracts and compare them with green tea (GT). Total polyphenol content of GM and RM extracts was found to be similar and to range from 237.20 to 438.50 mg gallic acid equivalent (GAE) ...

  20. Elite futsal refereeing: Activity profile and physiological demands

    Rebelo, António N.; Ascensão, António A.; Magalhães, José F.;

    2011-01-01

    the game. Endurance capacity was determined with the Yo-Yo IE2. The number of activity changes was as high as 1,395 ± 218 (±SD). Total distance covered, high-intensity running (HIR), sprinting (SPR), and sideways running were 5.89 ± 0.56, 0.96 ± 0.29, 0.09 ± 0.07, and 0.91 ± 0.46 km, respectively. The....... Considering the data obtained in the present study, the use of match-specific intermittent fitness tests to evaluate futsal referees seems to be required....

  1. Turtle Graphics: Exercises in Haskell

    Boiten, Eerke Albert

    2004-01-01

    This document contains a collection of programming exercises in the functional programming language Haskell. The exercises are all concerned with Turtle Graphics - interpreting and generating programs for ''turtles''.

  2. 3D for Graphic Designers

    Connell, Ellery

    2011-01-01

    Helping graphic designers expand their 2D skills into the 3D space The trend in graphic design is towards 3D, with the demand for motion graphics, animation, photorealism, and interactivity rapidly increasing. And with the meteoric rise of iPads, smartphones, and other interactive devices, the design landscape is changing faster than ever.2D digital artists who need a quick and efficient way to join this brave new world will want 3D for Graphic Designers. Readers get hands-on basic training in working in the 3D space, including product design, industrial design and visualization, modeling, ani

  3. Computer graphics in engineering education

    Rogers, David F

    2013-01-01

    Computer Graphics in Engineering Education discusses the use of Computer Aided Design (CAD) and Computer Aided Manufacturing (CAM) as an instructional material in engineering education. Each of the nine chapters of this book covers topics and cites examples that are relevant to the relationship of CAD-CAM with engineering education. The first chapter discusses the use of computer graphics in the U.S. Naval Academy, while Chapter 2 covers key issues in instructional computer graphics. This book then discusses low-cost computer graphics in engineering education. Chapter 4 discusses the uniform b

  4. Computer-assisted information graphics from the graphic design perspective

    Marcus, A.

    1983-11-01

    Computer-assisted information graphics can benefit by adopting some of the working processes, principles, and areas of concern typical of information-oriented graphic designers. A review of some basic design considerations is followed by a discussion of the creation and design of a prototype nonverbal narrative which combines symbols, charts, maps, and diagrams.

  5. Transforming Graphical System Models to Graphical Attack Models

    Ivanova, Marieta Georgieva; Probst, Christian W.; Hansen, Rene Rydhof;

    2016-01-01

    approach to transforming graphical system models to graphical attack models in the form of attack trees. Based on an asset in the model, our transformations result in an attack tree that represents attacks by all possible actors in the model, after which the actor in question has obtained the asset....

  6. Alkaloid profiling and anticholinesterase activity of South American Lycopodiaceae species.

    Konrath, Eduardo Luis; Ortega, María Gabriela; de Loreto Bordignon, Sérgio; Apel, Miriam Anders; Henriques, Amélia Teresinha; Cabrera, José Luis

    2013-02-01

    The alkaloid extracts of four Huperzia and one Lycopodiella species, from Brazilian habitats, were tested for their in vitro anticholinesterase activities. IC(50) values showed a potent acetylcholinesterase inhibition for H. reflexa (0.11 ± 0.05 μg/mL), followed by H. quadrifariata (2.0 ± 0.3 μg/mL), H. acerosa (5.5 ± 0.9 μg/mL), H. heterocarpon (25.6 ± 2.7 μg/mL) and L. cernua (42.6 ± 1.5 μg/mL). A lower inhibition of butyrylcholinesterase was observed for all species with the exception of H. heterocarpon (8.3 ± 0.9 μg/mL), whose alkaloid extract presented a selectivity for pseudocholinesterase. Moreover, the chemical study of the bioactive extracts performed by GC-MS, revealed the presence of a number of Lycopodium alkaloids belonging to the lycopodane, flabellidane and cernuane groups. Surprisingly, the potent acetylcholinesterase inhibitors huperzines A and B were not detected in the extracts, suggesting that other alkaloids may be responsible for such an effect. PMID:22117191

  7. A profile of the in vitro antitumor activity of lissoclinolide

    Lissoclinolide is a small non-nitrogenous lactone isolated from the marine ascidian Lissoclinum patella. Previous studies of lissoclinolide (isolated from a fungus and an actinomycete) have identified varying activity against both Gram-negative and Gram-positive bacteria. In this study, lissoclinolide was able to inhibit cell growth in various mammalian tumor lines at an average IC50 of 395 nM (determined by MTT conversion after 48-h treatment). Treatment of HCT 116 human colon tumor cells with 2.4 μM lissoclinolide resulted in a strong arrest in the G2/M phase of the cell cycle after 24-h exposure. A daughter cell line lacking p53 showed an identical response while there was a slight increase in cytotoxicity towards a p21 null cell line. Although treatment with 2.4 μM lissoclinolide did not result in apoptosis after 48 h, this arrest was not reversible when drug wash out was attempted. The mechanism of action does not appear to involve tubulin, ubiquitin-specific isopeptidases, p53 or p21. COMPARE analysis in the NCI 60 cell line tumor panel revealed a moderate selectivity towards colon tumor cell lines

  8. Development of computer graphics

    Nuttall, H.E. [Univ. of New Mexico, Albuquerque, NM (US). Dept. of Chemical and Nuclear Engineering

    1989-07-01

    The purpose of this project was to screen and evaluate three graphics packages as to their suitability for displaying concentration contour graphs. The information to be displayed is from computer code simulations describing air-born contaminant transport. The three evaluation programs were MONGO (John Tonry, MIT, Cambridge, MA, 02139), Mathematica (Wolfram Research Inc.), and NCSA Image (National Center for Supercomputing Applications at the University of Illinois at Urbana-Champaign). After a preliminary investigation of each package, NCSA Image appeared to be significantly superior for generating the desired concentration contour graphs. Hence subsequent work and this report describes the implementation and testing of NCSA Image on both an Apple MacII and Sun 4 computers. NCSA Image includes several utilities (Layout, DataScope, HDF, and PalEdit) which were used in this study and installed on Dr. Ted Yamada`s Mac II computer. Dr. Yamada provided two sets of air pollution plume data which were displayed using NCSA Image. Both sets were animated into a sequential expanding plume series.

  9. An atomic orbital-based formulation of analytical gradients and nonadiabatic coupling vector elements for the state-averaged complete active space self-consistent field method on graphical processing units

    Snyder, James W.; Hohenstein, Edward G.; Luehr, Nathan; Martínez, Todd J., E-mail: toddjmartinez@gmail.com [Department of Chemistry and The PULSE Institute, Stanford University, Stanford, California 94305 (United States); SLAC National Accelerator Laboratory, Menlo Park, California 94025 (United States)

    2015-10-21

    We recently presented an algorithm for state-averaged complete active space self-consistent field (SA-CASSCF) orbital optimization that capitalizes on sparsity in the atomic orbital basis set to reduce the scaling of computational effort with respect to molecular size. Here, we extend those algorithms to calculate the analytic gradient and nonadiabatic coupling vectors for SA-CASSCF. Combining the low computational scaling with acceleration from graphical processing units allows us to perform SA-CASSCF geometry optimizations for molecules with more than 1000 atoms. The new approach will make minimal energy conical intersection searches and nonadiabatic dynamics routine for molecular systems with O(10{sup 2}) atoms.

  10. An atomic orbital-based formulation of analytical gradients and nonadiabatic coupling vector elements for the state-averaged complete active space self-consistent field method on graphical processing units

    We recently presented an algorithm for state-averaged complete active space self-consistent field (SA-CASSCF) orbital optimization that capitalizes on sparsity in the atomic orbital basis set to reduce the scaling of computational effort with respect to molecular size. Here, we extend those algorithms to calculate the analytic gradient and nonadiabatic coupling vectors for SA-CASSCF. Combining the low computational scaling with acceleration from graphical processing units allows us to perform SA-CASSCF geometry optimizations for molecules with more than 1000 atoms. The new approach will make minimal energy conical intersection searches and nonadiabatic dynamics routine for molecular systems with O(102) atoms

  11. An atomic orbital-based formulation of analytical gradients and nonadiabatic coupling vector elements for the state-averaged complete active space self-consistent field method on graphical processing units

    Snyder, James W.; Hohenstein, Edward G.; Luehr, Nathan; Martínez, Todd J.

    2015-10-01

    We recently presented an algorithm for state-averaged complete active space self-consistent field (SA-CASSCF) orbital optimization that capitalizes on sparsity in the atomic orbital basis set to reduce the scaling of computational effort with respect to molecular size. Here, we extend those algorithms to calculate the analytic gradient and nonadiabatic coupling vectors for SA-CASSCF. Combining the low computational scaling with acceleration from graphical processing units allows us to perform SA-CASSCF geometry optimizations for molecules with more than 1000 atoms. The new approach will make minimal energy conical intersection searches and nonadiabatic dynamics routine for molecular systems with O(102) atoms.

  12. System of graphics digitization (SGD)

    The system of graphics digitization (SGD) consisting of hard- and software is presented in this paper. Two variances of its realization are described: using of a semiautomatic device and using of a scanner. The data of digitization of test graphics and obtained results are analysed

  13. Activity profile of the CA125 antigen towards human red blood cells

    Mitić N.

    2010-01-01

    Full Text Available Starting from the mucin nature of the CA125 antigen and conditions associated with high serum concentrations, this study is an attempt to gain insight into its activity profile towards human erythrocytes. Carcinomaassociated and pregnancy-associated CA125 antigens were tested in agglutination/aggregation, adhesion and hemolysis assays. The results obtained indicated that CA125 antigens increased agglutination/aggregation and inhibited erythrocyte adhesion, but differed in their effective concentrations. Galectin-1 slightly modulated the effects observed. CA125 antigens had no effect on hemolysis. The activity profile of the CA125 antigen towards erythrocytes may have biomedical consequences in different microenvironments in relevant physiological and pathophysiological conditions.

  14. Activity Profiles and Physiological Responses of Representative Tag Football Players in Relation to Playing Position and Physical Fitness

    Luke W Hogarth; Burkett, Brendan J; McKean, Mark R.

    2015-01-01

    This study determined the physical fitness, match-activity profiles and physiological responses of representative tag football players and examined the relationship between physical fitness and the match-activity profile. Microtechnology devices and heart rate (HR) chest straps were used to determine the match-activity profiles of sixteen tag football players for five matches during the 2014 Australian National Championships. The relationships between lower body muscular power, straight line ...

  15. A comparison of the activity profile and physiological demands between advanced and recreational veteran tennis players

    J. Fernandez-Fernandez; D. Sanz-Rivas; C. Sanchez-Muñoz; B.M. Pluim; I. Tiemessen; A. Mendez-Villanueva

    2009-01-01

    The aim of the study was to examine whether differences in playing level influence the activity profile and physiological demands of advanced and recreational veteran men's tennis players during an hour of tennis match play. Ten advanced (International Tennis Number [ITN] 3-5, 45.3 +/- 5.1 years) an

  16. GENETIC ACTIVITY PROFILES AND PATTERN RECOGNITION IN TEST BATTERY SELECTION (JOURNAL VERSION)

    Computer-generated genetic activity profiles and pairwise matching procedures may aid in the selection of the most appropriate short-term bioassays to be used in test batteries for the evaluation of the genotoxicity of a given chemical or group of chemicals. Selection of test bat...

  17. Assimilation of active microwave observation data for soil moisture profile estimation

    Hoeben, R.; Troch, P.A.

    2000-01-01

    This paper discusses the potential of retrieving information about the soil moisture profile from measurements of the surface soil moisture content through active microwave observations of the Earth. Recently, Mancini et al. [1999] have shown through laboratory experiments that the volumetric moistu

  18. Elemental profiles of soil in and around Tirupati by reactor neutron activation using KO method

    Soil samples, representatives of various places in and around Tirupati, Andhra Pradesh, that are affected by industrial effluents and sewages, were analysed for the elemental profiles by neutron activation analysis (NAA) using Ko method. Concentrations of 23 elements were measured. Variation in concentration of important elements with respect to influence on vegetation is discussed. (author). 2 refs., 1 tab

  19. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects

    A graphical method of analysis applicable to ligands that bind reversibly to receptors or enzymes requiring the simultaneous measurement of plasma and tissue radioactivities for multiple times after the injection of a radiolabeled tracer is presented. It is shown that there is a time t after which a plot of integral of t0ROI(t')dt'/ROI(t) versus integral of t0Cp(t')dt'/ROI(t) (where ROI and Cp are functions of time describing the variation of tissue radioactivity and plasma radioactivity, respectively) is linear with a slope that corresponds to the steady-state space of the ligand plus the plasma volume,.Vp. For a two-compartment model, the slope is given by lambda + Vp, where lambda is the partition coefficient and the intercept is -1/[kappa 2(1 + Vp/lambda)]. For a three-compartment model, the slope is lambda(1 + Bmax/Kd) + Vp and the intercept is -(1 + Bmax/Kd)/k2 + [koff(1 + Kd/Bmax)]-1 [1 + Vp/lambda(1 + Bmax/Kd)]-1 (where Bmax represents the concentration of ligand binding sites and Kd the equilibrium dissociation constant of the ligand-binding site complex, koff (k4) the ligand-binding site dissociation constant, and k2 is the transfer constant from tissue to plasma). This graphical method provides the ratio Bmax/Kd from the slope for comparison with in vitro measures of the same parameter. It also provides an easy, rapid method for comparison of the reproducibility of repeated measures in a single subject, for longitudinal or drug intervention protocols, or for comparing experimental results between subjects. Although the linearity of this plot holds when ROI/Cp is constant, it can be shown that, for many systems, linearity is effectively reached some time before this. This analysis has been applied to data from [N-methyl-11C]-(-)-cocaine studies in normal human volunteers and the results are compared to the standard nonlinear least-squares analysis

  20. Stratified Graphical Models - Context-Specific Independence in Graphical Models

    Nyman, Henrik; Pensar, Johan; Koski, Timo; Corander, Jukka

    2014-01-01

    Theory of graphical models has matured over more than three decades to provide the backbone for several classes of models that are used in a myriad of applications such as genetic mapping of diseases, credit risk evaluation, reliability and computer security, etc. Despite of their generic applicability and wide adoptance, the constraints imposed by undirected graphical models and Bayesian networks have also been recognized to be unnecessarily stringent under certain circumstances. This observ...

  1. Activity based protein profiling to detect serine hydrolase alterations in virus infected cells

    MdShahiduzzaman; KevinM.Coombs

    2012-01-01

    Activity-based protein profiling (ABPP) is a newly emerging technique that uses active site-directed probes to monitor the functional status of enzymes. Serine hydrolases are one of the largest families of enzymes in mammals. More than 200 serine hydrolases have been identified, but little is known about their specific roles. Serine hydrolases are involved in a variety of physiological functions, including digestion, immune response, blood coagulation, and reproduction. ABPP has been used rec...

  2. Lipid Profile and Serum Paraoxonase1 Activity in CRF Patients Pre and Posthemodialysis

    Nitin S. Nagane1* and Jayshree V. Ganu2

    2011-01-01

    Chronic renal failure (CRF) is associated with an increased risk of cardiovascular disease (CVD). In the present study, 30 CRF patients undergoing hemodialysis and 50 healthy controls matching in age and sex were included. We have estimated blood urea, serum creatinine, lipid profile and serum Paraoxonase1 (PON1) activity in pre and post hemodialytic samples. HDL-Cholesterol (HDLC) and serum Paraoxonase1(PON1) activity was found to be significantly reduced (P

  3. Enforcing creativity in graphic design

    Erdurak, Naciye Derin

    2002-01-01

    Ankara : The Department of Graphic Design and Institute of Fine Arts of Bilkent University, 2002. Thesis (Master's) -- Bilkent University, 2002. Includes bibliographical references leaves 73-75. Erdurak, Naciye Derin Master's

  4. Digital Raster Graphics (DRG) Lambert

    Kansas Data Access and Support Center — The Digital Raster Graphic-Lambert (DRG-Lam) is a raster image of a scanned USGS topographic map with the collar information clipped out, georeferenced to the...

  5. Interaction of open graphic dynamics

    Dugowson, Stéphane

    2015-01-01

    The aim of this paper is to define what we shall call open graphic dynamics, their interactions and the dynamics produced by those interactions. It prepares the study of "open sub-categorical dynamics" and "open categorical dynamics".

  6. Mining functional modules in genetic networks with decomposable graphical models.

    Dejori, Mathäus; Schwaighofer, Anton; Tresp, Volker; Stetter, Martin

    2004-01-01

    In recent years, graphical models have become an increasingly important tool for the structural analysis of genome-wide expression profiles at the systems level. Here we present a new graphical modelling technique, which is based on decomposable graphical models, and apply it to a set of gene expression profiles from acute lymphoblastic leukemia (ALL). The new method explains probabilistic dependencies of expression levels in terms of the concerted action of underlying genetic functional modules, which are represented as so-called "cliques" in the graph. In addition, the method uses continuous-valued (instead of discretized) expression levels, and makes no particular assumption about their probability distribution. We show that the method successfully groups members of known functional modules to cliques. Our method allows the evaluation of the importance of genes for global cellular functions based on both link count and the clique membership count. PMID:15268775

  7. IAU Graphics Extension - Gnu C

    Denver, Troelz; Jørgensen, John Leif; Riis, Troels

    1999-01-01

    This document contains a description of the library GrxIau (former UtilVesa and UTILLE). The library acts as shell to the graphics commands used at the exercises at the course 50240 Image Analysis with Microcomputers.......This document contains a description of the library GrxIau (former UtilVesa and UTILLE). The library acts as shell to the graphics commands used at the exercises at the course 50240 Image Analysis with Microcomputers....

  8. Graphic design of pinhole cameras

    Edwards, H. B.; Chu, W. P.

    1979-01-01

    The paper describes a graphic technique for the analysis and optimization of pinhole size and focal length. The technique is based on the use of the transfer function of optical elements described by Scott (1959) to construct the transfer function of a circular pinhole camera. This transfer function is the response of a component or system to a pattern of lines having a sinusoidally varying radiance at varying spatial frequencies. Some specific examples of graphic design are presented.

  9. Programming Graphic Processing Units (GPUs)

    Bakke, Glenn Ruben Årthun

    2009-01-01

    In this thesis we do a broad study of the languages, libraries and frameworks for general purpose computations on graphics processors. We have also studied the different graphics processor architectures that has been developed the last decade. 8 example programs in OpenGL, CUDA, MPI and OpenMP has been made to emphasize the mechanisms for parallelization and memory managment. The example programs have been benchmarked and the source lines are been counted. We found out that programs for th...

  10. Graphics editors in CPDev environment

    Marcin Jamro

    2012-01-01

    According to IEC 61131-3 norm, controllers and distributed control systems can be programmed in textual and graphical languages. In many scenarios using a graphical language is preferred by the user, because diagrams can be more legible and easier to understand or modify also by people who do not have strong programming skills. What is more, they can be attached to the documentation to present a part of a system implementation. CPDev is an engineering environment that makes possible to progra...

  11. Positivity for Gaussian graphical models

    Draisma, Jan; Sullivant, Seth; Talaska, Kelli

    2012-01-01

    Gaussian graphical models are parametric statistical models for jointly normal random variables whose dependence structure is determined by a graph. In previous work, we introduced trek separation, which gives a necessary and sufficient condition in terms of the graph for when a subdeterminant is zero for all covariance matrices that belong to the Gaussian graphical model. Here we extend this result to give explicit cancellation-free formulas for the expansions of nonzero subdeterminants.

  12. GRAPHIC AND REPRESENTABLE FUZZIFYING MATROIDS

    Chun-E Huang

    2010-01-01

    In this paper, a fuzzifying matroid is induced respectively from a fuzzy graph and a fuzzy vector subspace. The concepts of graphic fuzzifying matroid and representable fuzzifying matroid are presented and some properties of them are discussed. In general, a graphic fuzzifying matriod can not be representable over any field. But when a fuzzifying matroid is isomorphic to a fuzzifying cycle matroid which is induced by a fuzzy tree, it is a representable over any field.

  13. Investigating the active hydrothermal field of Kolumbo Volcano using CTD profiling

    Eleni Christopoulou, Maria; Mertzimekis, Theo; Nomikou, Paraskevi; Papanikolaou, Dimitrios; Carey, Steve

    2014-05-01

    The submarine Kolumbo volcano NE of Santorini Island and the unique active hydrothermal vent field on its crater field (depth ~ 500 m) have been recently explored in multiple cruises aboard E/V Nautilus. ROV explorations showed the existence of extensive vent activity and almost completely absence of vent-specific macrofauna. Gas discharges have been found to be 99%-rich in CO2, which is sequestered at the bottom of the crater due to a special combination of physicochemical and geomorphological factors. The dynamic conditions existing along the water column in the crater have been studied in detail by means of temperature, salinity and conductivity depth profiles for the first time. CTD sensors aboard the ROV Hercules were employed to record anomalies in those parameters in an attempt to investigate several active and inactive vent locations. Temporal CTD monitoring inside and outside of the crater was carried out over a period of two years. Direct comparison between the vent field and locations outside the main cone, where no hydrothermal activity is known to exist, showed completely different characteristics. CTD profiles above the active vent field (NNE side) are correlated to Kolumbo's cone morphology. The profiles suggest the existence of four distinct zones of physicochemical properties in the water column. The layer directly above the chimneys exhibit gas discharges highly enriched in CO2. Continuous gas motoring is essential to identify the onset of geological hazards in the region.

  14. Heating and active control of profiles and transport by IBW in the HT-7 tokamak

    Significant progress on Ion Bernstein Wave (IBW) heating and control of profiles has been obtained in HT-7. Both on-axis and off-axis electron heating with global peaked and local steep electron pressure profiles were realized if the position of the resonant layer was selected to be plasma far from the plasma edge region. Reduction of electron heat transport has been observed from sawtooth heat pulse propagation. Improvement of both particle and energy confinement was slight in the on-axis and considerable in the off-axis heating cases. The improved confinement in off-axis heating mode may be due to the extension of the high performance plasma volume caused by IBW. These studies demonstrate that IBWs are potentially a tool for active control of plasma profiles and transport. (author)

  15. Comparing of 2D Graphical Applications

    Hokešová, Daniela

    2014-01-01

    This work focuses on comparison of the selected graphic editors. Editors selected for this work are programs GIMP, Zoner Draw, Adobe Photoshop, Inkscape. Individual graphics software for raster and vector graphics are analyzed and then compared in terms of installation, graphical user interface application areas supported formats orientation program to create and edit graphic images and personal experiences of the author. The best raster graphics editor was evaluated program Adobe Pho...

  16. Phytochemical profiles, antioxidant activities of functional herb Abrus cantoniensis and Abrus mollis.

    Yang, Mei; Shen, Qing; Li, Lin-Qiu; Huang, Ye-Qing; Cheung, Hon-Yeung

    2015-06-15

    It has been claimed that consumptions of Abrus cantoniensis (AC) and Abrus mollis (AM) as folk beverages and soups are good to cleanse liver toxicants and prevent liver diseases. There is scant information on the phytochemical profiles and antioxidant activities of these two varieties. Five major phytochemicals in these two cultivars were qualitatively and quantitatively compared using UPLC-PDA. A high level of total phenolic content (TPC) and total flavonoid content (TFC) was found in AC and AM. AC, in general, showed some antioxidant activities comparable to that of BHT, and stronger radical scavenging activities and higher reducing power than that of AM (pfoods or beverages to promote health function. PMID:25660890

  17. Comparative Analysis of Click Chemistry Mediated Activity-Based Protein Profiling in Cell Lysates

    Yinliang Yang

    2013-10-01

    Full Text Available Activity-based protein profiling uses chemical probes that covalently attach to active enzyme targets. Probes with conventional tags have disadvantages, such as limited cell permeability or steric hindrance around the reactive group. A tandem labeling strategy with click chemistry is now widely used to study enzyme targets in situ and in vivo. Herein, the probes are reacted in live cells, whereas the ensuing detection by click chemistry takes place in cell lysates. We here make a comparison of the efficiency of the activity-based tandem labeling strategy by using Cu(I-catalyzed and strain-promoted click chemistry, different ligands and different lysis conditions.

  18. Modeling chemical kinetics graphically

    A. Heck

    2012-01-01

    In literature on chemistry education it has often been suggested that students, at high school level and beyond, can benefit in their studies of chemical kinetics from computer supported activities. Use of system dynamics modeling software is one of the suggested quantitative approaches that could h

  19. Fluorescent profiling of modular biosynthetic enzymes by complementary metabolic and activity based probes.

    Meier, Jordan L; Mercer, Andrew C; Burkart, Michael D

    2008-04-23

    The study of the enzymes responsible for natural product biosynthesis has proven a valuable source of new enzymatic activities and been applied to a number of biotechnology applications. Protein profiling could prove highly complementary to genetics based approaches by allowing us to understand the activity, transcriptional control, and post-translational modification of these enzymes in their native and dynamic proteomic environments. Here we present a method for the fluorescent profiling of PKS, NRPS, and FAS multidomain modular synthases in their whole proteomes using complementary metabolic and activity based probes. After first examining the reactivity of these activity based probes with a variety of purified recombinant PKS, NRPS, and FAS enzymes in vitro, we apply this duel labeling strategy to the analysis of modular synthases in a human breast cancer cell line and two strains of the natural product producer Bacillus subtilis. Collectively, these studies demonstrate that complementary protein profiling approaches can prove highly useful in the identification and assignment of inhibitor specificity and domain structure of these modular biosynthetic enzymes. PMID:18376827

  20. Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation.

    Duncan, Mark T; Shin, Seungjin; Wu, Jia J; Mays, Zachary; Weng, Stanley; Bagheri, Neda; Miller, William M; Shea, Lonnie D

    2014-10-01

    The directed differentiation toward erythroid (E) or megakaryocytic (MK) lineages by the MK-E progenitor (MEP) could enhance the ex vivo generation of red blood cells and platelets for therapeutic transfusions. The lineage choice at the MEP bifurcation is controlled in large part by activity within the intracellular signal transduction network, the output of which determines the activity of transcription factors (TFs) and ultimately gene expression. Although many TFs have been implicated, E or MK differentiation is a complex process requiring multiple days, and the dynamics of TF activities during commitment and terminal maturation are relatively unexplored. Herein, we applied a living cell array for the large-scale, dynamic quantification of TF activities during MEP bifurcation. A panel of hematopoietic TFs (GATA-1, GATA-2, SCL/TAL1, FLI-1, NF-E2, PU.1, c-Myb) was characterized during E and MK differentiation of bipotent K562 cells. Dynamic TF activity profiles associated with differentiation towards each lineage were identified, and validated with previous reports. From these activity profiles, we show that GATA-1 is an important hub during early hemin- and PMA-induced differentiation, and reveal several characteristic TF interactions for E and MK differentiation that confirm regulatory mechanisms documented in the literature. Additionally, we highlight several novel TF interactions at various stages of E and MK differentiation. Furthermore, we investigated the mechanism by which nicotinamide (NIC) promoted terminal MK maturation using an MK-committed cell line, CHRF-288-11 (CHRF). Concomitant with its enhancement of ploidy, NIC strongly enhanced the activity of three TFs with known involvement in terminal MK maturation: FLI-1, NF-E2, and p53. Dynamic profiling of TF activity represents a novel tool to complement traditional assays focused on mRNA and protein expression levels to understand progenitor cell differentiation. PMID:24853077

  1. Anthropometric profile and habits of physical activity of a scho ol students Mapuches rural Temuco, Chile

    Pablo Antonio Valdés-Badilla

    2015-04-01

    Full Text Available Introduction: The nutritional status of children can be a predictor of health in adulthood element, the Mapuche population has a non-Mapuche population that increased prevalence of obesity in Chile. The aim of this study was to determine the anthropometric profile and physical activity habits of Mapuche students of a particular charter school in the rural of Temuco city.Material and Methods: The design is not experimental, descriptive, transversal, with a quantitative approach. The sample included all students of the educational establishment Mapuches (n=23, in both sexes. He underwent anthropometric assessment ISAK and total time physical activity was estimated by the International Physical Activity Questionnaire, short version in Spanish (IPAQ-A. To correlate the variables a partial correlation was used.Results: The students average about 35.4% of fat mass, muscle mass 34.1%, 11.4% of residual mass, 12% of bone mass, 7% of residual mass and somatotype 4.9–5.1–1.8 that meso-endomorph classified as balanced. Regarding the total time physical activity, students reach 2225.9 minutes/week, your energy expenditure is 9592.1 (METs/min/week and stay seated equals 228.6 minutes per week, finally negative correlation was found between BMI and total time of physical activity.Conclusions: The students have a mostly standard anthropometric profile, but with a troubling obesity rate. His activity level is high, placing them as active subjects according to normative tables.

  2. Computer graphics in architecture and engineering

    Greenberg, D. P.

    1975-01-01

    The present status of the application of computer graphics to the building profession or architecture and its relationship to other scientific and technical areas were discussed. It was explained that, due to the fragmented nature of architecture and building activities (in contrast to the aerospace industry), a comprehensive, economic utilization of computer graphics in this area is not practical and its true potential cannot now be realized due to the present inability of architects and structural, mechanical, and site engineers to rely on a common data base. Future emphasis will therefore have to be placed on a vertical integration of the construction process and effective use of a three-dimensional data base, rather than on waiting for any technological breakthrough in interactive computing.

  3. TLAPrfl: Package for calculation of depth profile for thin layer activation. Summary of contents

    TLAPrfl computer code package provides an easy means of calculating depth profiles of radioactivity induced by incident beam of charge particles in target material. The technique is commonly referred to as Thin Layer Activation (TLA). TLA profiles can be calculated for 35 reactions leading to specific activity induced by p, d, 3He or α with incident energy up to 44 MeV on 12 isotopes and elements. IonStop code for calculation of ion energy loss characteristic in medium is also included. A diskette with TLAPrfl code package is available upon request, cost-free, from the IAEA Nuclear Data Section. Users with access to Internet may download TLAPrfl.zip file (379 KB) from http://www-nds.iaea.or.at/reports/data/tlaprfl.zip. (author)

  4. Evaluation of Activation Energy (Ea) Profiles of Nanostructured Alumina Polycarbonate Composite Insulation Materials

    Sudha L. K.; Sukumar Roy; K. Uma Rao

    2014-01-01

    This paper focuses enhancement of the electrical insulation properties of commercial polycarbonate using nanostructured alumina as an additive material. Various polycarbonate composites have been prepared by varying the level of additive material and DC conductivity in presence of oxygen of the derived composite materials has been measured in which activation energy (Ea) profiles of the composites have been evaluated. Results show that the incorporation of additive significantly reduces the E...

  5. Polyphenolic Profile, Antioxidant and Anti-Inflammatory Activity of Eastern Teaberry (Gaultheria procumbens L.) Leaf Extracts

    Piotr Michel; Anna Dobrowolska; Agnieszka Kicel; Aleksandra Owczarek; Agnieszka Bazylko; Sebastian Granica; Piwowarski, Jakub P.; Olszewska, Monika A.

    2014-01-01

    Dry leaf extracts of eastern teaberry (Gaultheria procumbens L.) were evaluated as a source of bioactive phytocompounds through systematic activity testing and phytochemical profiling. The antioxidant efficiency was tested using five complementary in vitro models (DPPH; FRAP; linoleic acid (LA) peroxidation assay; O2•− and H2O2 scavenging tests) in parallel with standard antioxidants. The 75% methanol extract and its diethyl ether, ethyl acetate (EAF), n-butanol and water fractions exhibited ...

  6. Effects of Orange Juice and Hesperetin on Serum Paraoxonase Activity and Lipid Profile in Hyperuricemic Rats

    Fatemeh Haidari; Mohammad-Reza Rashidi; Majid Mohammad-Shahi

    2012-01-01

    Introduction: Hypouricemic, antioxidant and xanthine oxidase inhibitory effects of orange juice and hesperetin have been already indicated. The objective of this study was to investigate the effects of orange juice and hesperetin on paraoxonase and arylesterase activity and lipid profile of hyperuricemic rats. Methods: Forty eight male Wistar rats were divided into 8 equal groups of healthy control, healthy+orange juice, healthy+hesperetin, healthy+allopurinol, hyperuricemic control, hyperuri...

  7. Profiling Physical Activity, Diet, Screen and Sleep Habits in Portuguese Children

    Sara Pereira; Katzmarzyk, Peter T.; Thayse Natacha Gomes; Alessandra Borges; Daniel Santos; Michele Souza; dos Santos, Fernanda K.; Chaves, Raquel N.; Champagne, Catherine M.; Barreira, Tiago V.; Maia, José A. R.

    2015-01-01

    Obesity in children is partly due to unhealthy lifestyle behaviours, e.g., sedentary activity and poor dietary choices. This trend has been seen globally. To determine the extent of these behaviours in a Portuguese population of children, 686 children 9.5 to 10.5 years of age were studied. Our aims were to: (1) describe profiles of children’s lifestyle behaviours; (2) identify behaviour pattern classes; and (3) estimate combined effects of individual/ socio-demographic characteristics in pred...

  8. Cytokinin and Auxin Display Distinct but Interconnected Distribution and Signaling Profiles to Stimulate Cambial Activity.

    Immanen, Juha; Nieminen, Kaisa; Smolander, Olli-Pekka; Kojima, Mikiko; Alonso Serra, Juan; Koskinen, Patrik; Zhang, Jing; Elo, Annakaisa; Mähönen, Ari Pekka; Street, Nathaniel; Bhalerao, Rishikesh P; Paulin, Lars; Auvinen, Petri; Sakakibara, Hitoshi; Helariutta, Ykä

    2016-08-01

    Despite the crucial roles of phytohormones in plant development, comparison of the exact distribution profiles of different hormones within plant meristems has thus far remained scarce. Vascular cambium, a wide lateral meristem with an extensive developmental zonation, provides an optimal system for hormonal and genetic profiling. By taking advantage of this spatial resolution, we show here that two major phytohormones, cytokinin and auxin, display different yet partially overlapping distribution profiles across the cambium. In contrast to auxin, which has its highest concentration in the actively dividing cambial cells, cytokinins peak in the developing phloem tissue of a Populus trichocarpa stem. Gene expression patterns of cytokinin biosynthetic and signaling genes coincided with this hormonal gradient. To explore the functional significance of cytokinin signaling for cambial development, we engineered transgenic Populus tremula × tremuloides trees with an elevated cytokinin biosynthesis level. Confirming that cytokinins function as major regulators of cambial activity, these trees displayed stimulated cambial cell division activity resulting in dramatically increased (up to 80% in dry weight) production of the lignocellulosic trunk biomass. To connect the increased growth to hormonal status, we analyzed the hormone distribution and genome-wide gene expression profiles in unprecedentedly high resolution across the cambial zone. Interestingly, in addition to showing an elevated cambial cytokinin content and signaling level, the cambial auxin concentration and auxin-responsive gene expression were also increased in the transgenic trees. Our results indicate that cytokinin signaling specifies meristematic activity through a graded distribution that influences the amplitude of the cambial auxin gradient. PMID:27426519

  9. Graphics editors in CPDev environment

    Marcin Jamro

    2012-03-01

    Full Text Available According to IEC 61131-3 norm, controllers and distributed control systems can be programmed in textual and graphical languages. In many scenarios using a graphical language is preferred by the user, because diagrams can be more legible and easier to understand or modify also by people who do not have strong programming skills. What is more, they can be attached to the documentation to present a part of a system implementation. CPDev is an engineering environment that makes possible to program PLCs, PACs, softPLCs and distributed control systems with the usage of languages defined in IEC 61131-3 norm. In earlier versions, it supported only textual languages - ST and IL. Currently, graphics editors for FBD, LD and SFC languages are also available, so users can choose a suitable language depending on their skills and a specificity of a program that they have to prepare. The article presents implementation of the graphics editors, made by the author, which support creating program organization units in all graphical languages defined in IEC 61131-3 norm. They are equipped with a set of basic and complex functionalities to provide an easy and intuitive way of creating programs, function blocks and functions with visual programming. In the article the project structure and some important mechanisms are described. They include e.g. automatic connections finding (with A* algorithm, translation to ST code, conversion to and from XML format and an execution mode supporting multiple data sources and breakpoints.

  10. Configurable software for satellite graphics

    Hartzman, P D

    1977-12-01

    An important goal in interactive computer graphics is to provide users with both quick system responses for basic graphics functions and enough computing power for complex calculations. One solution is to have a distributed graphics system in which a minicomputer and a powerful large computer share the work. The most versatile type of distributed system is an intelligent satellite system in which the minicomputer is programmable by the application user and can do most of the work while the large remote machine is used for difficult computations. At New York University, the hardware was configured from available equipment. The level of system intelligence resulted almost completely from software development. Unlike previous work with intelligent satellites, the resulting system had system control centered in the satellite. It also had the ability to reconfigure software during realtime operation. The design of the system was done at a very high level using set theoretic language. The specification clearly illustrated processor boundaries and interfaces. The high-level specification also produced a compact, machine-independent virtual graphics data structure for picture representation. The software was written in a systems implementation language; thus, only one set of programs was needed for both machines. A user can program both machines in a single language. Tests of the system with an application program indicate that is has very high potential. A major result of this work is the demonstration that a gigantic investment in new hardware is not necessary for computing facilities interested in graphics.

  11. Ontogenetic changes in digestive enzyme activities and the amino acid profile of starry flounder Platichthys stellatus

    Song, Zhidong; Wang, Jiying; Qiao, Hongjin; Li, Peiyu; Zhang, Limin; Xia, Bin

    2016-09-01

    Ontogenetic changes in digestive enzyme activities and the amino acid (AA) profile of starry flounder, Platichthys stellatus, were investigated and limiting amino acids were estimated compared with the essential AA profile between larvae and live food to clarify starry flounder larval nutritional requirements. Larvae were collected at the egg stage and 0, 2, 4, 7, 12, 17, 24 days after hatching (DAH) for analysis. Larvae grew from 1.91 mm at hatching to 12.13 mm at 24 DAH. Trypsin and chymotrypsin activities changed slightly by 4 DAH and then increased significantly 4 DAH. Pepsin activity increased sharply beginning 17 DAH. Lipase activity increased significantly 4 DAH and increased progressively with larval growth. Amylase activity was also detected in newly hatched larvae and increased 7 DAH followed by a gradual decrease. High free amino acid (FAA) content was detected in starry flounder eggs (110.72 mg/g dry weight). Total FAA content dropped to 43.29 mg/g in 4-DAH larvae and then decreased gradually to 13.74 mg/g in 24-DAH larvae. Most FAAs (except lysine and methionine) decreased >50% in 4-DAH larvae compared with those in eggs and then decreased to the lowest values in 24-DAH larvae. Changes in the protein amino acid (PAA) profile were much milder than those observed for FAAs. Most PAAs increased gradually during larval development, except lysine and phenylalanine. The percentages of free threonine, valine, isoleucine, and leucine decreased until the end of the trial, whereas the protein forms of these four AAs followed the opposite trend. A comparison of the essential AA composition of live food (rotifers, Artemia nauplii, and Artemia metanauplii) and larvae suggested that methionine was potentially the first limiting AA. These results may help develop starry flounder larviculture methods by solving the AA imbalance in live food. Moreover, the increased digestive enzyme activities indicate the possibility of introducing artificial compound feed.

  12. Ontogenetic changes in digestive enzyme activities and the amino acid profile of starry flounder Platichthys stellatus

    Song, Zhidong; Wang, Jiying; Qiao, Hongjin; Li, Peiyu; Zhang, Limin; Xia, Bin

    2016-01-01

    Ontogenetic changes in digestive enzyme activities and the amino acid (AA) profile of starry flounder, Platichthys stellatus, were investigated and limiting amino acids were estimated compared with the essential AA profile between larvae and live food to clarify starry flounder larval nutritional requirements. Larvae were collected at the egg stage and 0, 2, 4, 7, 12, 17, 24 days after hatching (DAH) for analysis. Larvae grew from 1.91 mm at hatching to 12.13 mm at 24 DAH. Trypsin and chymotrypsin activities changed slightly by 4 DAH and then increased significantly 4 DAH. Pepsin activity increased sharply beginning 17 DAH. Lipase activity increased significantly 4 DAH and increased progressively with larval growth. Amylase activity was also detected in newly hatched larvae and increased 7 DAH followed by a gradual decrease. High free amino acid (FAA) content was detected in starry flounder eggs (110.72 mg/g dry weight). Total FAA content dropped to 43.29 mg/g in 4-DAH larvae and then decreased gradually to 13.74 mg/g in 24-DAH larvae. Most FAAs (except lysine and methionine) decreased >50% in 4-DAH larvae compared with those in eggs and then decreased to the lowest values in 24-DAH larvae. Changes in the protein amino acid (PAA) profile were much milder than those observed for FAAs. Most PAAs increased gradually during larval development, except lysine and phenylalanine. The percentages of free threonine, valine, isoleucine, and leucine decreased until the end of the trial, whereas the protein forms of these four AAs followed the opposite trend. A comparison of the essential AA composition of live food (rotifers, Artemia nauplii, and Artemia metanauplii) and larvae suggested that methionine was potentially the first limiting AA. These results may help develop starry flounder larviculture methods by solving the AA imbalance in live food. Moreover, the increased digestive enzyme activities indicate the possibility of introducing artificial compound feed.

  13. Lifted Graphical Models: A Survey

    Mihalkova, Lilyana

    2011-01-01

    This article presents a survey of work on lifted graphical models. We review a general form for a lifted graphical model, a par-factor graph, and show how a number of existing statistical relational representations map to this formalism. We discuss inference algorithms, including lifted inference algorithms, that efficiently compute the answers to probabilistic queries. We also review work in learning lifted graphical models from data. It is our belief that the need for statistical relational models (whether it goes by that name or another) will grow in the coming decades, as we are inundated with data which is a mix of structured and unstructured, with entities and relations extracted in a noisy manner from text, and with the need to reason effectively with this data. We hope that this synthesis of ideas from many different research groups will provide an accessible starting point for new researchers in this expanding field.

  14. Relativistic Hydrodynamics on Graphic Cards

    Gerhard, Jochen; Bleicher, Marcus

    2012-01-01

    We show how to accelerate relativistic hydrodynamics simulations using graphic cards (graphic processing units, GPUs). These improvements are of highest relevance e.g. to the field of high-energetic nucleus-nucleus collisions at RHIC and LHC where (ideal and dissipative) relativistic hydrodynamics is used to calculate the evolution of hot and dense QCD matter. The results reported here are based on the Sharp And Smooth Transport Algorithm (SHASTA), which is employed in many hydrodynamical models and hybrid simulation packages, e.g. the Ultrarelativistic Quantum Molecular Dynamics model (UrQMD). We have redesigned the SHASTA using the OpenCL computing framework to work on accelerators like graphic processing units (GPUs) as well as on multi-core processors. With the redesign of the algorithm the hydrodynamic calculations have been accelerated by a factor 160 allowing for event-by-event calculations and better statistics in hybrid calculations.

  15. Fractal geometry and computer graphics

    Sakas, Georgios; Peitgen, Heinz-Otto; Englert, Gabriele

    1992-01-01

    Fractal geometry has become popular in the last 15 years, its applications can be found in technology, science, or even arts. Fractal methods and formalism are seen today as a general, abstract, but nevertheless practical instrument for the description of nature in a wide sense. But it was Computer Graphics which made possible the increasing popularity of fractals several years ago, and long after their mathematical formulation. The two disciplines are tightly linked. The book contains the scientificcontributions presented in an international workshop in the "Computer Graphics Center" in Darmstadt, Germany. The target of the workshop was to present the wide spectrum of interrelationships and interactions between Fractal Geometry and Computer Graphics. The topics vary from fundamentals and new theoretical results to various applications and systems development. All contributions are original, unpublished papers.The presentations have been discussed in two working groups; the discussion results, together with a...

  16. Graphical Passwords Authentication: A Survey

    Nikhil Tarkeshwar Ambade

    2015-02-01

    Full Text Available In typically text-based passwords, well known users often create memorable passwords that are easy for attackers to guess, but strong system-assigned passwords are difficult for users to remember. Reusing same or easy passwords across different accounts help to memorability, but decrease in security. Text passwords are the most popular user authentication method, but have security and usability problems. Alternatives such as biometric systems and tokens have their own drawbacks Graphical passwords offer another alternative. This paper conducts a comprehensive survey of the existing graphical password techniques also classifies these techniques into three categories: recall, recognition, and cued-recall approaches. This paper discusses security and usability aspects of graphical password techniques and point out the future research directions in this area.

  17. Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

    Van Nostrand William E

    2006-09-01

    Full Text Available Abstract Background Microglia are associated with neuritic plaques in Alzheimer disease (AD and serve as a primary component of the innate immune response in the brain. Neuritic plaques are fibrous deposits composed of the amyloid beta-peptide fragments (Abeta of the amyloid precursor protein (APP. Numerous studies have shown that the immune cells in the vicinity of amyloid deposits in AD express mRNA and proteins for pro-inflammatory cytokines, leading to the hypothesis that microglia demonstrate classical (Th-1 immune activation in AD. Nonetheless, the complex role of microglial activation has yet to be fully explored since recent studies show that peripheral macrophages enter an "alternative" activation state. Methods To study alternative activation of microglia, we used quantitative RT-PCR to identify genes associated with alternative activation in microglia, including arginase I (AGI, mannose receptor (MRC1, found in inflammatory zone 1 (FIZZ1, and chitinase 3-like 3 (YM1. Results Our findings confirmed that treatment of microglia with anti-inflammatory cytokines such as IL-4 and IL-13 induces a gene profile typical of alternative activation similar to that previously observed in peripheral macrophages. We then used this gene expression profile to examine two mouse models of AD, the APPsw (Tg-2576 and Tg-SwDI, models for amyloid deposition and for cerebral amyloid angiopathy (CAA respectively. AGI, MRC1 and YM1 mRNA levels were significantly increased in the Tg-2576 mouse brains compared to age-matched controls while TNFα and NOS2 mRNA levels, genes commonly associated with classical activation, increased or did not change, respectively. Only TNFα mRNA increased in the Tg-SwDI mouse brain. Alternative activation genes were also identified in brain samples from individuals with AD and were compared to age-matched control individuals. In AD brain, mRNAs for TNFα, AGI, MRC1 and the chitinase-3 like 1 and 2 genes (CHI3L1; CHI3L2 were

  18. Differences in activity profile of bacterial cultures studied by dynamic speckle patterns

    Ramírez-Miquet, E. E.; Otero, I.; Rodríguez, D.; Darias, J. G.; Combarro, A. M.; Contreras, O. R.

    2013-02-01

    We outline the main differences in the activity profile of bacterial cultures studied by dynamic laser speckle (or biospeckle) patterns. The activity is detected in two sorts of culture mediums. The optical setup and the experimental procedure are presented. The experimentally obtained images are processed by the temporal difference method and a qualitative assessment is made with the time history of speckle patterns of the sample. The main differences are studied after changing the culture medium composition. We conclude that the EC medium is suitable to detect the E. coli bacterial presence in early hours and that Mueller Hinton agar delays some additional hours to make possible the assessment of bacteria in time.

  19. 802.16e System Profile for NASA Extra-Vehicular Activities

    Foore, Lawrence R.; Chelmins, David T.; Nguyen, Hung D.; Downey, Joseph A.; Finn, Gregory G.; Cagley, Richard E.; Bakula, Casey J.

    2009-01-01

    This report identifies an 802.16e system profile that is applicable to a lunar surface wireless network, and specifically for meeting extra-vehicular activity (EVA) data flow requirements. EVA suit communication needs are addressed. Design-driving operational scenarios are considered. These scenarios are then used to identify a configuration of the 802.16e system (system profile) that meets EVA requirements, but also aim to make the radio realizable within EVA constraints. Limitations of this system configuration are highlighted. An overview and development status is presented by Toyon Research Corporation concerning the development of an 802.16e compatible modem under NASA s Small Business Innovative Research (SBIR) Program. This modem is based on the recommended system profile developed as part of this report. Last, a path forward is outlined that presents an evolvable solution for the EVA radio system and lunar surface radio networks. This solution is based on a custom link layer, and 802.16e compliant physical layer compliant to the identified system profile, and a later progression to a fully interoperable 802.16e system.

  20. Vocational Teaching Cube System of Engineering Graphics

    YangDaofu; LiuShenli

    2003-01-01

    Based on long-time research on vocational teaching cube theory in graphics education and analyzing on the intellectual structure in the process of reading engineering drawing, the graphics intellectual three-dimensional model, which is made up of 100 cubes, is founded and tested in higher vocational graphics education. This system serves as a good guidance to the graphics teaching.

  1. Antinomies of Semiotics in Graphic Design

    Storkerson, Peter

    2010-01-01

    The following paper assesses the roles played by semiotics in graphic design and in graphic design education, which both reflects and shapes practice. It identifies a series of factors; graphic design education methods and culture; semiotic theories themselves and their application to graphic design; the two wings of Peircian semiotics and…

  2. Comprehending, Composing, and Celebrating Graphic Poetry

    Calo, Kristine M.

    2011-01-01

    The use of graphic poetry in classrooms is encouraged as a way to engage students and motivate them to read and write poetry. This article discusses how graphic poetry can help students with their comprehension of poetry while tapping into popular culture. It is organized around three main sections--reading graphic poetry, writing graphic poetry,…

  3. Generating Explanatory Captions for Information Graphics

    Mittal, Vibhu O.; Roth, Steven F.; Moore, Johanna D.; Mattis, Joe; Carenini, Giuseppe

    1995-01-01

    Graphical presentations can be used to communicate information in relational data sets succinctly and effectively. However, novel graphical presentationsabout numerous attributes and their relationships are often difficult to understand completely until explained. Automatically generated graphical presentations must therefore either be limited to simple, conventional ones, or risk incomprehensibility. One way of alleviating this problem is to design graphical presentation systems that can wor...

  4. Activity Profile and Energy Expenditure Among Active Older Adults, British Columbia, 2011–2012

    Madden, Kenneth M.; Ashe, Maureen C; Chase, Jocelyn M.

    2015-01-01

    Introduction Time spent by young adults in moderate to vigorous activity predicts daily caloric expenditure. In contrast, caloric expenditure among older adults is best predicted by time spent in light activity. We examined highly active older adults to examine the biggest contributors to energy expenditure in this population. Methods Fifty-four community-dwelling men and women aged 65 years or older (mean, 71.4 y) were enrolled in this cross-sectional observational study. All were members of...

  5. Digital Colour in Graphic Design

    Pender, Ken

    1998-01-01

    Complete, practical guide to handling colour graphics on the desktop for Mac and PC - from the scanning, creation and manipulation of images to processing for different colour output devices. Keep this handy book on your desk to help you achieve more professional-looking results in colour for a wide variety of tasks.An accompanying CD-ROM allows you to view practical examples of colour techniques in graphic design on the screen, demonstrating the techniques described in the book.The underlying principles of digital colour are explained in detail:? colour models? ways in which scanners, monitor

  6. Touch gestures for process graphics

    Andersson, Victoria

    2016-01-01

    The goal of this thesis was to explore and find ways to implement touch gestures in the context of process automation, with the limitation to one specific use case found suitable for touch interaction for ABB’s distributed control system called System 800xA. The typical way to handle the data in System 800xA today is to show and control it through the so called process graphics. It is possible to do this on a touch device today, but the current graphical user interface focus on mouse and keyb...

  7. The magic of computer graphics

    Kurachi, Noriko

    2011-01-01

    Computer graphics is a vast field that is becoming larger every day. It is impossible to cover every topic of interest, even within a specialization such as CG rendering. For many years, Noriko Kurachi has reported on the latest developments for Japanese readers in her monthly column for CG World. Being something of a pioneer herself, she selected topics that represented original and promising new directions for research. Many of these novel ideas are the topics covered in The Magic of Computer Graphics. Starting from the basic behavior of light, the first section of the book introduces the mo

  8. Future body mass index modelling based on macronutrient profiles and physical activity

    Cundiff David K

    2012-10-01

    Full Text Available Abstract Background An accurate system of determining the relationship of macronutrient profiles of foods and beverages to the long-term weight impacts of foods is necessary for evidence-based, unbiased front-of-the-package food labels. Methods Data sets on diet, physical activity, and BMI came from the Food and Agriculture Organization (FAO, the World Health Organization (WHO, the Diabetes Control and Complications Trial (DCCT, and Epidemiology Diabetes Intervention and Complications (EDIC. To predict future BMI of individuals, multiple regression derived FAO/WHO and DCCT/EDIC formulas related macronutrient profiles and physical activity (independent variables to BMI change/year (dependent variable. Similar formulas without physical activity related macronutrient profiles of individual foods and beverages to four-year weight impacts of those items and compared those forecasts to published food group profiling estimates from three large prospective studies by Harvard nutritional epidemiologists. Results FAO/WHO food and beverage formula: four-year weight impact (pounds=(0.07710 alcohol g+11.95 (381.7+carbohydrates g per serving*4/(2,613+kilocalories per serving–304.9 (30.38+dietary fiber g per serving/(2,613+kilocalories per serving+19.73 (84.44+total fat g*9/(2,613+kilocalories per serving–68.57 (20.45+PUFA g per serving*9/(2,613+kilocalories per serving*2.941–12.78 (n=334, R2=0.29, P 2=0.03, P P = 0.0004. Formula predictions did not correlate with food group profiling findings for potatoes and dairy products (n=10, r= −0.33 P=0.36. A formula based diet and exercise analysis tool is available to researchers and individuals: http://thehealtheconomy.com/healthTool/. Conclusions Two multiple regression derived formulas from dissimilar databases produced markedly similar estimates of future BMI for 1,055 individuals with type 1 diabetes and female and male cohorts from 167 countries. These formulas predicted the long-term weight impacts of

  9. Enhanced detection of hydraulically active fractures by temperature profiling in lined heated bedrock boreholes

    Pehme, P. E.; Parker, B. L.; Cherry, J. A.; Molson, J. W.; Greenhouse, J. P.

    2013-03-01

    SummaryThe effectiveness of borehole profiling using a temperature probe for identifying hydraulically active fractures in rock has improved due to the combination of two advances: improved temperature sensors, with resolution on the order of 0.001 °C, and temperature profiling within water inflated flexible impermeable liners used to temporarily seal boreholes from hydraulic cross-connection. The open-hole cross-connection effects dissipate after inflation, so that both the groundwater flow regime and the temperature distribution return to the ambient (background) condition. This paper introduces a third advancement: the use of an electrical heating cable that quickly increases the temperature of the entire static water column within the lined hole and thus places the entire borehole and its immediate vicinity into thermal disequilibrium with the broader rock mass. After heating for 4-6 h, profiling is conducted several times over a 24 h period as the temperature returns to background conditions. This procedure, referred to as the Active Line Source (ALS) method, offers two key improvements over prior methods. First, there is no depth limit for detection of fractures with flow. Second, both identification and qualitative comparison of evidence for ambient groundwater flow in fractures is improved throughout the entire test interval. The benefits of the ALS method are demonstrated by comparing results from two boreholes tested to depths of 90 and 120 m in a dolostone aquifer used for municipal water supply and in which most groundwater flow occurs in fractures. Temperature logging in the lined holes shows many fractures in the heterothermic zone both with and without heating, but only the ALS method shows many hydraulically active fractures in the deeper homothermic portion of the hole. The identification of discrete groundwater flow at many depths is supported by additional evidence concerning fracture occurrence, including continuous core visual inspection

  10. 2005 DOE Computer Graphics Forum Site Survey

    Rebecca, S; Eric, B

    2005-04-15

    The Information Management and Graphics Group supports and develops tools that enhance our ability to access, display, and understand large, complex data sets. Activities include developing visualization software for terascale data exploration; running two video production labs; supporting graphics libraries and tools for end users; maintaining four PowerWalls and assorted other advanced displays; and providing integrated tools for searching, organizing, and browsing scientific data. The Data group supports Defense and Nuclear technologies (D&NT) Directorate. The group's visualization team has developed and maintains two visualization tools: MeshTV and VisIt. These are interactive graphical analysis tools for visualizing and analyzing data on two- and three-dimensional meshes. They also provide movie production support. Researchers in the Center for Applied Scientific Computing (CASC) work on various projects including the development of visualization and data mining techniques for terascale data exploration that are funded by ASC. The researchers also have LDRD projects and collaborations with other lab researchers, academia, and industry.

  11. Yields, Phenolic Profiles and Antioxidant Activities of Ziziphus jujube Mill. in Response to Different Fertilization Treatments

    Min Wang

    2013-09-01

    Full Text Available Increasing demand for more jujube (Ziziphus jujube Mill. production requires understanding the specific fertilization needs of jujube trees. This study was conducted to compare fruit yields, phenolic profiles and antioxidant activity of jujube in response to different fertilizers. Application of organic fertilizer appeared to enhance the phenolics and antioxidant activity accumulation of jujubes, compared to conventional fertilized jujubes. Amongst inorganic fertilizers, supplemental potassium as an individual nutrient improved the accumulation of phenolics in jujubes. Our results demonstrate that phenolics levels and antioxidant activity of jujube can be manipulated through fertilizer management and tracked by following proanthocyanidin concentrations. In a practical production context, the combination of organic fertilizers and inorganic fertilizers such as more supplemental individual potassium, and less supplemental individual nitrogen and phosphorus, might be the best management combination for achieving higher phenolic concentration, stronger antioxidant activity and a good harvest.

  12. An improved user interface for an interactive graphics figure illustrator

    Beda, Thomas John

    1987-01-01

    Approved for public release; distribution is unlimited This study discusses briefly the history of technical figure illustration in the Computer Science Department of the Naval Postgraduate School. The single system experiencing the most usage is the fully automated interactive graphics figure illustrator- OZDRAW. During its short and active life, the need for perfective maintenance to include generalized documentation has been recognized. The result is a technical graphics figure illus...

  13. Porto Maphazardly - Representation of Place in Graphic Design

    Mccarthy, Alice

    2015-01-01

    This project, Porto Maphazardly, examines the role of a graphic designer in exploring alternate means of mapping a location. A square in the Portuguese city of Porto was mapped through five sensory approaches: sound, smell, taste, activity, and color perception. The data that was gathered was translated into visuals to create a generated, but totally unique, graphic portrait of a place. The portmanteau maphazardly in the title combines the word ‘map’ with the adverb, ‘haphazard...

  14. Trend Monitoring System (TMS) graphics software

    Brown, J. S.

    1979-01-01

    A prototype bus communications systems, which is being used to support the Trend Monitoring System (TMS) and to evaluate the bus concept is considered. A set of FORTRAN-callable graphics subroutines for the host MODCOMP comuter, and an approach to splitting graphics work between the host and the system's intelligent graphics terminals are described. The graphics software in the MODCOMP and the operating software package written for the graphics terminals are included.

  15. Real-time volume graphics

    Engel, Klaus; Kniss, Joe; Rezk-Salama, Christof; Weiskopf, Daniel

    2006-01-01

    Based on course notes of SIGGRAPH course teaching techniques for real-time rendering of volumetric data and effects; covers both applications in scientific visualization and real-time rendering. Starts with the basics (texture-based ray casting) and then improves and expands the algorithms incrementally. Book includes source code, algorithms, diagrams, and rendered graphics.

  16. Fluid simulation for computer graphics

    Bridson, Robert

    2008-01-01

    Animating fluids like water, smoke, and fire using physics-based simulation is increasingly important in visual effects, in particular in movies, like The Day After Tomorrow, and in computer games. This book provides a practical introduction to fluid simulation for graphics. The focus is on animating fully three-dimensional incompressible flow, from understanding the math and the algorithms to the actual implementation.

  17. Graphical fiber shaping control interface

    Basso, Eric T.; Ninomiya, Yasuyuki

    2016-03-01

    In this paper, we present an improved graphical user interface for defining single-pass novel shaping techniques on glass processing machines that allows for streamlined process development. This approach offers unique modularity and debugging capability to researchers during the process development phase not usually afforded with similar scripting languages.

  18. GRAPHIC INTERFACES FOR ENGINEERING APPLICATIONS

    Ion PANA,

    2012-05-01

    Full Text Available Using effective the method of calculating Fitness for Service requires the achievement of graphical interfaces. This paper presents an example of such interfaces, made with Visual Basic program and used in the evaluation of pipelines in a research contract [4

  19. In Defense of Graphic Novels

    Hansen, Kathryn Strong

    2012-01-01

    In the 18th century, critics grumbled about a new literary form that supposedly threatened the abilities of youth to distinguish between reality and artificiality. This form was the novel, one of the literary forms that critics now hold dearest. Currently, the graphic novel receives a great deal of criticism. Yet many teachers have shown how…

  20. Omani propolis: chemical profiling, antibacterial activity and new propolis plant sources

    2013-01-01

    Background Propolis (bee glue) is a resinous honeybee product having a long history of application in many countries as a traditional remedy for treating wounds, burns, soar throat, stomach disorders, etc. It has been proved to possess beneficial biological effects, including antimicrobial, antioxidant, anti-inflammatory, cytotoxic, antiulcer, and many others. Bees gather propolis from diverse resinous plant parts and in different phytogeographic regions its chemical composition might vary significantly. In this article we report the results of the first study on the chemical profiles of propolis from Oman, its plant origin and antibacterial activity. Results The chemical profiles of Omani propolis extracts were obtained by GC-MS analysis after silylation. Over 50 individual compounds were identified in the samples, belonging to different compound types: sugars, polyols, hydroxy acids, fatty acids, cardanols and cardols, anacardic acids, flavan derivatives, triterpenes, prenylated flavanones and chalcones. The profiles were dissimilar from other known propolis types. They demonstrate that although Oman is not a large country, the plant sources of propolis vary significantly, even in the same apiary and the same season. Based on chemical profiles, and isolation and identification of major marker compounds (new propolis constituents), new plant sources of propolis were found: Azadiracta indica (neem tree) and Acacia spp. (most probably A. nilotica). The ethanol extracts of the studied propolis samples demonstrated activity against S. aureus (MIC < 100 μg. mL-1) and E. coli (MIC < 380 μg. mL-1). Conclusion Omani propolis is different form the known propolis types and demonstrates significant chemical diversity. Its most important plant source is the resin of Azadirachta indica, and as a result its typical components are С5-prenyl flavanones. Other plant sources have been identified, too, playing some role in resin collection by bees in Oman: Acacia spp

  1. A Multi-Agent Mah Jong Playing System: Towards Real-Time Recognition of Graphic Units in Graphic Representations

    H. Achten; Jessurun, J

    2003-01-01

    In architectural design, sketching is an important means to explore the first conceptual developments in the design process. It is necessary to understand the conventions of depiction and encoding in sketches and drawings if we want to support the architect in the sketching activity. The theory of graphic units provides a comprehensive list of conventions of depiction and encoding that are widely used among architects. These graphic units form useful building blocks to understand design drawi...

  2. Molecular graphics-structural and molecular graphics descriptors in a QSAR study of 17-a-acetoxyprogesterones

    Kiralj Rudolf; Ferreira Márcia M. C.

    2003-01-01

    Quantitative Structure-Activity Relationship study on 21 oral progestogens, 19 of which are 17-alpha-acetoxyprogesterones, was performed by using Partial Least Squares. Fairly good regression models were achieved, the best being Q²=0.707, R²=0.811 with two Principal Components and four descriptors. Most of the molecular descriptors were generated from molecular graphics of DFT 6-31G** optimized geometries (molecular graphics descriptors) or were additionally combined with experimental structu...

  3. Sustained mitogen-activated protein kinase activation reprograms defense metabolism and phosphoprotein profile in Arabidopsis thaliana.

    Ines eLassowskat

    2014-10-01

    Full Text Available Mitogen-activated protein kinases (MAPKs target a variety of protein substrates to regulate cellular signaling processes in eukaryotes. In plants, the number of identified MAPK substrates that control plant defense responses is still limited. Here, we generated transgenic Arabidopsis thaliana plants with an inducible system to simulate in vivo activation of two stress-activated MAPKs, MPK3 and MPK6. Metabolome analysis revealed that this artificial MPK3/6 activation (without any exposure to pathogens or other stresses is sufficient to drive the production of major defense-related metabolites, including various camalexin, indole glucosinolate and agmatine derivatives. An accompanying (phosphoproteome analysis led to detection of hundreds of potential phosphoproteins downstream of MPK3/6 activation. Besides known MAPK substrates, many candidates on this list possess typical MAPK-targeted phosphosites and in many cases, the corresponding phosphopeptides were detected by mass spectrometry. Notably, several of these putative phosphoproteins have been reported to be associated with the biosynthesis of antimicrobial defense substances (e.g. WRKY transcription factors and proteins encoded by the genes from the PEN pathway required for penetration resistance to filamentous pathogens. Thus, this work provides an inventory of candidate phosphoproteins, including putative direct MAPK substrates, for future analysis of MAPK-mediated defense control. (Proteomics data are available with the identifier PXD001252 via ProteomeXchange, http://proteomecentral.proteomexchange.org.

  4. Environmental profile analysis

    The Institute for Ecological Chemistry of the GSF in Munich, West Germany, developed a test system to evaluate the potential environmental hazard of chemicals. This so-called Environmental Profile Analysis is a test system for the screening of chemicals for their environmental behavior. The test system consists of the following five tests: (1) bio-accumulation in algae; (2) bio-accumulation in fish; (3) retention, dispersion, and excretion in rats (warm-blooded animals); (4) degradation, transformation and accumulation in activated sludge (microbial process); (5) photomineralization (abiotic process). The test system involves the use of radio-labeled test materials. This allows the use of scintillation counting as the universal analytical method and avoids the significant analytical limitations other methods are faced with. Also, the very sensitive method of scintillation counting allows the detection of traces of test materials and/or transformation products. Difficulties and risks of the use of radioactive materials can be eliminated by following strictly the procedures of the guidelines. A series of more than one hundred compounds belonging to widely different classes of compounds and displaying widely different application patterns and physicochemical properties has been tested so far. The test data for all the parameters of the five tests can be graphically presented creating a profile of parameters. The profile of the unknown materials is compared with the profile of compounds which are known to impose a burden on the environment. Potentially hazardous material is identified by similarities of the profiles and additional investigation should be performed. Through this comparison of profiles, the ecotoxicological profile analysis allows a quick recognition of potentially hazardous chemicals

  5. Reverse-engineering graphical innovation: an introduction to graphical regimes

    Dominic Arsenault

    2013-03-01

    Full Text Available Technological innovation in the video games industry is a rich area of research that has barely been explored as of yet. Gamers are always clamoring for novelty and a remedy to the oft-decried “sequelitis” that “plagues” the industry, while game publishers and platform holders secretly plan a next-gen platform to capture the ever-shifting market. In this light, the importance of graphics cannot be understated, as it is usually taken for granted in game historiography that “[g]ame graphics were, and to a large extent still are, the main criteria by which advancing video game technology is benchmarked” (Wolf, 2003, p.53.

  6. Polyphenolic Profile and Antioxidant Activities of Oolong Tea Infusion under Various Steeping Conditions

    Feng Chen

    2007-11-01

    Full Text Available The phenolic profile and antioxidant activities of oolong tea extract wereinvestigated after tea was steeped in 90 or 100 oC water for 3 or 10 min. The extractionyield increased with increasing temperature and extended steeping time. However, highertemperature and longer time (100 oC water for 10 min led to loss of phenolics. Theaqueous extract of oolong tea (AEOT at 100 oC for 3 min exhibited the strongestantioxidant activity. The major polyphenolic components of the AEOT were identified as(--epigallocatechin (EGC, (--epigallocatechin gallate (EGCG and (--epicatechin-3-gallate (ECG. The two major catechins (EGC and EGCG in the tea infusion contributedsignificantly to the investigated antioxidant activities [i.e., the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH radical scavenging and superoxide radical scavengingactivities] with high correlation values in r = 0.9486 and 0.9327 for the EGC and r =0.9592 and 0.8718 for the EGCG, respectively.

  7. Activity based protein profiling to detect serine hydrolase alterations in virus infected cells

    MdShahiduzzaman

    2012-08-01

    Full Text Available Activity based protein profiling (ABPP is a newly emerging technique that uses active site-directed probes to monitor the functional status of enzymes. Serine hydrolases are one of the largest families of enzymes in mammals. More than 200 serine hydrolases have been identified but little is known about their specific roles. Serine hydrolases are involved in a variety of physiological functions, including digestion, immune response, blood coagulation and reproduction. ABPP has been used recently to investigate host-virus interactions and to understand the molecular pathogenesis of virus infections. Monitoring the altered serine hydrolases during viral infection gives insight into the catalytic activity of these enzymes that will help to identify novel targets for diagnostic and therapeutic application. This review presents the usefulness of ABPP in detecting and analyzing functional annotation of host cell serine hydrolases as a result of host-virus interaction.

  8. An Active High Impedance Surface for Low Profile Tunable and Steerable Antennas

    Costa, Filippo; Talarico, Salvatore; Valeri, Fabio M

    2009-01-01

    In this letter, an approach for designing a tunable and steerable antenna is presented. The antenna model is based on a wideband bow-tie radiating element mounted above an active Artificial Magnetic Conductor (AMC). The AMC geometry consists of a Frequency Selective Surface (FSS) printed on a thin grounded dielectric slab in which some chip-set varactor diodes are placed between the metallic elements and the backing plane through vias. The resulting antenna can be tuned over the S-Band by simply changing all varactor capacitances through an appropriate biasing voltage. Moreover, this structure can operate a beam scanning over each working frequency by applying an appropriate biasing voltage to the active elements of the AMC surface in accordance to leaky radiation principles. The low profile active antenna is characterized by an overall thickness of 5.32 mm, which corresponds to approximately lambda/24 at the centre of the operating band.

  9. Core microbial functional activities in ocean environments revealed by global metagenomic profiling analyses.

    Ferreira, Ari J S

    2014-06-12

    Metagenomics-based functional profiling analysis is an effective means of gaining deeper insight into the composition of marine microbial populations and developing a better understanding of the interplay between the functional genome content of microbial communities and abiotic factors. Here we present a comprehensive analysis of 24 datasets covering surface and depth-related environments at 11 sites around the world\\'s oceans. The complete datasets comprises approximately 12 million sequences, totaling 5,358 Mb. Based on profiling patterns of Clusters of Orthologous Groups (COGs) of proteins, a core set of reference photic and aphotic depth-related COGs, and a collection of COGs that are associated with extreme oxygen limitation were defined. Their inferred functions were utilized as indicators to characterize the distribution of light- and oxygen-related biological activities in marine environments. The results reveal that, while light level in the water column is a major determinant of phenotypic adaptation in marine microorganisms, oxygen concentration in the aphotic zone has a significant impact only in extremely hypoxic waters. Phylogenetic profiling of the reference photic/aphotic gene sets revealed a greater variety of source organisms in the aphotic zone, although the majority of individual photic and aphotic depth-related COGs are assigned to the same taxa across the different sites. This increase in phylogenetic and functional diversity of the core aphotic related COGs most probably reflects selection for the utilization of a broad range of alternate energy sources in the absence of light.

  10. Core microbial functional activities in ocean environments revealed by global metagenomic profiling analyses.

    Ari J S Ferreira

    Full Text Available Metagenomics-based functional profiling analysis is an effective means of gaining deeper insight into the composition of marine microbial populations and developing a better understanding of the interplay between the functional genome content of microbial communities and abiotic factors. Here we present a comprehensive analysis of 24 datasets covering surface and depth-related environments at 11 sites around the world's oceans. The complete datasets comprises approximately 12 million sequences, totaling 5,358 Mb. Based on profiling patterns of Clusters of Orthologous Groups (COGs of proteins, a core set of reference photic and aphotic depth-related COGs, and a collection of COGs that are associated with extreme oxygen limitation were defined. Their inferred functions were utilized as indicators to characterize the distribution of light- and oxygen-related biological activities in marine environments. The results reveal that, while light level in the water column is a major determinant of phenotypic adaptation in marine microorganisms, oxygen concentration in the aphotic zone has a significant impact only in extremely hypoxic waters. Phylogenetic profiling of the reference photic/aphotic gene sets revealed a greater variety of source organisms in the aphotic zone, although the majority of individual photic and aphotic depth-related COGs are assigned to the same taxa across the different sites. This increase in phylogenetic and functional diversity of the core aphotic related COGs most probably reflects selection for the utilization of a broad range of alternate energy sources in the absence of light.

  11. Aroma profile and volatiles odor activity along gold cultivar pineapple flesh.

    Montero-Calderón, Marta; Rojas-Graü, María Alejandra; Martín-Belloso, Olga

    2010-01-01

    Physicochemical attributes, aroma profile, and odor contribution of pineapple flesh were studied for the top, middle, and bottom cross-sections cut along the central axis of Gold cultivar pineapple. Relationships between volatile and nonvolatile compounds were also studied. Aroma profile constituents were determined by headspace solid-phase microextraction at 30 °C, followed by gas chromatography/mass spectrometry analysis. A total of 20 volatile compounds were identified and quantified. Among them, esters were the major components which accounted for 90% of total extracted aroma. Methyl butanoate, methyl 2-methyl butanoate, and methyl hexanoate were the 3 most abundant components representing 74% of total volatiles in pineapple samples. Most odor active contributors were methyl and ethyl 2-methyl butanoate and 2,5-dimethyl 4-methoxy 3(2H)-furanone (mesifuran). Aroma profile components did not vary along the fruit, but volatile compounds content significantly varied (P pineapple trays, compromising consumer perception and acceptance of the product. Such finding highlighted the need to include volatiles content and SSC/TA ratio and their variability along the fruit as selection criteria for pineapples to be processed and quality assessment of the fresh-cut fruit. PMID:21535624

  12. Cardiovascular risk profile: Cross-sectional analysis of motivational determinants, physical fitness and physical activity

    Kiers Henri

    2010-10-01

    Full Text Available Abstract Background Cardiovascular risk factors are associated with physical fitness and, to a lesser extent, physical activity. Lifestyle interventions directed at enhancing physical fitness in order to decrease the risk of cardiovascular diseases should be extended. To enable the development of effective lifestyle interventions for people with cardiovascular risk factors, we investigated motivational, social-cognitive determinants derived from the Theory of Planned Behavior (TPB and other relevant social psychological theories, next to physical activity and physical fitness. Methods In the cross-sectional Utrecht Police Lifestyle Intervention Fitness and Training (UP-LIFT study, 1298 employees (aged 18 to 62 were asked to complete online questionnaires regarding social-cognitive variables and physical activity. Cardiovascular risk factors and physical fitness (peak VO2 were measured. Results For people with one or more cardiovascular risk factors (78.7% of the total population, social-cognitive variables accounted for 39% (p In addition to the prediction of intention to engage in physical activity and physical active behavior, we explored the impact of the intensity of physical activity. The intentsity of physical activity was only significantly related to physical active behavior (beta = .253, p 2 = .06, p 2 = .23, p For people with one or more cardiovascular risk factors, 39.9% had positive intentions to engage in physical activity and were also physically active, and 10.5% had a low intentions but were physically active. 37.7% had low intentions and were physically inactive, and about 11.9% had high intentions but were physically inactive. Conclusions This study contributes to our ability to optimize cardiovascular risk profiles by demonstrating an important association between physical fitness and social-cognitive variables. Physical fitness can be predicted by physical active behavior as well as by self-efficacy and the intensity of

  13. Analysis of whey protein hydrolysates: peptide profile and ACE inhibitory activity

    Marialice Pinto Coelho Silvestre; Mauro Ramalho Silva; Viviane Dias Medeiros Silva; Mariana Wanessa Santana de Souza; Carlos de Oliveira Lopes Junior; Wendel de Oliveira Afonso

    2012-01-01

    The aim of this study was to prepare enzymatic hydrolysates from whey protein concentrate with a nutritionally adequate peptide profile and the ability to inhibit angiotensin-converting enzyme (ACE) activity. The effects of the type of enzyme used (pancreatin or papain), the enzyme:substrate ratio (E:S ratio=0.5:100, 1:100, 2:100 and 3:100) and the use of ultrafiltration (UF) were investigated. The fractionation of peptides was performed by size-exclusion-HPLC, and the quantification of the c...

  14. ON THE DIVERSITY AND COMPLEXITY OF ABSORPTION LINE PROFILES PRODUCED BY OUTFLOWS IN ACTIVE GALACTIC NUCLEI

    Understanding the origin of active galactic nucleus (AGN) absorption line profiles and their diversity could help to explain the physical structure of the accretion flow, and also to assess the impact of accretion on the evolution of the AGN host galaxies. Here, we present our first attempt to systematically address the issue of the origin of the complexities observed in absorption profiles. Using a simple method, we compute absorption line profiles against a continuum point source for several simulations of accretion disk winds. We investigate the geometrical, ionization, and dynamical effects on the absorption line shapes. We find that significant complexity and diversity of the absorption line profile shapes can be produced by the non-monotonic distribution of the wind velocity, density, and ionization state. Non-monotonic distributions of such quantities are present even in steady-state, smooth disk winds, and naturally lead to the formation of multiple and detached absorption troughs. These results demonstrate that the part of a wind where an absorption line is formed is not representative of the entire wind. Thus, the information contained in the absorption line is incomplete if not even insufficient to well estimate gross properties of the wind such as the total mass and energy fluxes. In addition, the highly dynamical nature of certain portions of disk winds can have important effects on the estimates of the wind properties. For example, the mass outflow rates can be off by up to two orders of magnitude with respect to estimates based on a spherically symmetric, homogeneous, constant velocity wind.

  15. DGLa:A Distributed Graphics Language

    潘志庚; 胡冰峰; 等

    1994-01-01

    A distributed graphics programming language called DGLa is presented,which facilitates the development of distributed graphics application.Facilities for distributed programming and graphics support are included in it,It not only supports synchronous and asynchronous communication but also provides programmer with multiple control mechanism for process communication.The graphics support of DGLa is powerful,for both sequential graphics library and parallel graphics library are provided.The design consideration and implementation experience are discussed in detail in this paper.Application examples are also given.

  16. Physical activity profiling: Activity-specific step counting and energy expenditure models using 3D wrist acceleration.

    Delgado-Gonzalo, R; Celka, P; Renevey, Ph; Dasen, S; Sola, J; Bertschi, M; Lemay, M

    2015-08-01

    In this paper, we present the evaluation of a new physical activity profiling system embedded in a wrist-located device. We propose a step counting and an energy expenditure (EE) method, and evaluate their accuracy against gold standard references. To this end, we used an actimetry sensor on the waist and an indirect calorimetry monitoring device on a population of 13 subjects to obtain step count and metabolic equivalent task (kcal/kg/h) referenced values. The subjects followed a protocol that spanned a given set of activities (lying, standing, walking, running) at a wide range of intensities. The performance of the EE model was characterized by a root-mean-square error (RMSE) of 1.22±0.34kcal/min, and step-count model at regular walking/running speeds by 0.71±0.06step/10sec. PMID:26738171

  17. Comparison of Activity Profiles and Physiological Demands Between International Rugby Sevens Matches and Training.

    Higham, Dean G; Pyne, David B; Anson, Judith M; Hopkins, Will G; Eddy, Anthony

    2016-05-01

    Higham, DG, Pyne, DB, Anson, JM, Hopkins, WG, and Eddy, A. Comparison of activity profiles and physiological demands between international rugby sevens matches and training. J Strength Cond Res 30(5): 1287-1294, 2016-The specificity of contemporary training practices of international rugby sevens players is unknown. We quantified the positional group-specific activity profiles and physiological demands of on-field training activities and compared these with match demands. Twenty-two international matches and 63 rugby-specific training drills were monitored in 25 backs and 17 forwards from a national squad of male rugby sevens players over a 21-month period. Drills were classified into 3 categories: low-intensity skill refining (n = 23 drills, 560 observations), moderate- to high-intensity skill refining (n = 28 drills, 600 observations), and game simulation (n = 12 drills, 365 observations). Movement patterns (via Global Positioning System devices) and physiological load (via heart rate monitors) were recorded for all activities, and the differences between training and matches were quantified using magnitude-based inferential statistics. Distance covered in total and at ≥3.5 m·s, maximal velocity, and frequency of accelerations and decelerations were lower for forwards during competition compared with those for backs by a small but practically important magnitude. No clear positional group differences were observed for physiological load during matches. Training demands exceeded match demands only for frequency of decelerations of forwards during moderate- to high-intensity skill-refining drills and only by a small amount. Accelerations and distance covered at ≥6 m·s were closer to match values for forwards than for backs during all training activities, but training drills consistently fell below the demands of international competition. Coaches could therefore improve physical and physiological specificity by increasing the movement demands and intensity of

  18. Representing Learning With Graphical Models

    Buntine, Wray L.; Lum, Henry, Jr. (Technical Monitor)

    1994-01-01

    Probabilistic graphical models are being used widely in artificial intelligence, for instance, in diagnosis and expert systems, as a unified qualitative and quantitative framework for representing and reasoning with probabilities and independencies. Their development and use spans several fields including artificial intelligence, decision theory and statistics, and provides an important bridge between these communities. This paper shows by way of example that these models can be extended to machine learning, neural networks and knowledge discovery by representing the notion of a sample on the graphical model. Not only does this allow a flexible variety of learning problems to be represented, it also provides the means for representing the goal of learning and opens the way for the automatic development of learning algorithms from specifications.

  19. Intuitive Music and Graphic Notation

    Bergstrøm-Nielsen, Carl

    Describes subjects existing at Aalborg University since the middle eighties. "Intuitive Music" trains free improvisation through exercises including group-dynamic exercises, awareness exercises and parameter exercises. Students also create open compositions. "Graphic notation"concerns aural scores....... Students' works are quoted. The writer discusses the theoretical context and advocates for giving more attention to music as the medium in which music therapy takes place, referring to language theory and Jakobson. NB: the description of the two subjects are, at the present moment (2011) no longer up to...... date. Intuitive music stresses less making compositions and more using the main instrument intuitively. Graphic notation has been integrated into a larger subject (also taught by the present author) which also comprises other methods of description and interpretation of music....

  20. Effect of Tomato Industrial Processing on Phenolic Profile and Antiplatelet Activity

    Iván Palomo

    2013-09-01

    Full Text Available Background: Regular consumption of fruits and vegetables (e.g., tomatoes has been shown to be beneficial in terms of reducing the incidence of cardiovascular diseases. The industrial processing of tomatoes into tomato-based products includes several thermal treatments. Very little is known on the effect of tomato industrial processing on antiaggregatory activity and phenolic profile. Methods: It was assessed the effect of tomato and by-products extracts on platelet aggregation induced by ADP, collagen, TRAP-6 and arachidonic acid. These in vitro antithrombotic properties were further supported in an in vivo model of thrombosis. A set of antiplatelet compounds has been selected for HPLC analysis in the different extracts. Results: Some natural compounds such as chlorogenic, caffeic, ferulic and p-coumaric acids were identified by HPLC in tomatoes and its products may inhibit platelet activation. Red tomatoes, tomato products (sauce, ketchup and juice and by-products extracts inhibited platelet aggregation induced adenosine 5'-diphosphate, collagen, thrombin receptor activator peptide-6 and arachidonic acid, but to a different extent. Also, pomace extract presents antithrombotic activity. Conclusions: Processed tomatoes may have a higher content of health-benefiting compounds than fresh ones. Pomace even presents the best antiplatelet activity. Finally, tomato products may be used as a functional ingredient adding antiplatelet activities to processed foods.

  1. Volatile profiling of aromatic traditional medicinal plant, Polygonum minus in different tissues and its biological activities.

    Ahmad, Rafidah; Baharum, Syarul Nataqain; Bunawan, Hamidun; Lee, Minki; Mohd Noor, Normah; Rohani, Emelda Roseleena; Ilias, Norashikin; Zin, Noraziah Mohamad

    2014-01-01

    The aim of this research was to identify the volatile metabolites produced in different organs (leaves, stem and roots) of Polygonum minus, an important essential oil producing crop in Malaysia. Two methods of extraction have been applied: Solid Phase Microextraction (SPME) and hydrodistillation coupled with Gas Chromatography-Mass Spectrometry (GC-MS). Approximately, 77 metabolites have been identified and aliphatic compounds contribute significantly towards the aroma and flavour of this plant. Two main aliphatic compounds: decanal and dodecanal were found to be the major contributor. Terpenoid metabolites were identified abundantly in leaves but not in the stem and root of this plant. Further studies on antioxidant, total phenolic content, anticholinesterase and antimicrobial activities were determined in the essential oil and five different extracts. The plant showed the highest DPPH radical scavenging activity in polar (ethanol) extract for all the tissues tested. For anti-acetylcholinesterase activity, leaf in aqueous extract and methanol extract showed the best acetylcholinesterase inhibitory activities. However, in microbial activity, the non-polar extracts (n-hexane) showed high antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA) compared to polar extracts. This study could provide the first step in the phytochemical profiles of volatile compounds and explore the additional value of pharmacology properties of this essential oil producing crop Polygonum minus. PMID:25420073

  2. Volatile Profiling of Aromatic Traditional Medicinal Plant, Polygonum minus in Different Tissues and Its Biological Activities

    Rafidah Ahmad

    2014-11-01

    Full Text Available The aim of this research was to identify the volatile metabolites produced in different organs (leaves, stem and roots of Polygonum minus, an important essential oil producing crop in Malaysia. Two methods of extraction have been applied: Solid Phase Microextraction (SPME and hydrodistillation coupled with Gas Chromatography-Mass Spectrometry (GC-MS. Approximately, 77 metabolites have been identified and aliphatic compounds contribute significantly towards the aroma and flavour of this plant. Two main aliphatic compounds: decanal and dodecanal were found to be the major contributor. Terpenoid metabolites were identified abundantly in leaves but not in the stem and root of this plant. Further studies on antioxidant, total phenolic content, anticholinesterase and antimicrobial activities were determined in the essential oil and five different extracts. The plant showed the highest DPPH radical scavenging activity in polar (ethanol extract for all the tissues tested. For anti-acetylcholinesterase activity, leaf in aqueous extract and methanol extract showed the best acetylcholinesterase inhibitory activities. However, in microbial activity, the non-polar extracts (n-hexane showed high antimicrobial activity against Methicillin-resistant Staphylococcus aureus (MRSA compared to polar extracts. This study could provide the first step in the phytochemical profiles of volatile compounds and explore the additional value of pharmacology properties of this essential oil producing crop Polygonum minus.

  3. Mixed scale joint graphical lasso

    Pircalabelu, Eugen; Claeskens, Gerda; Waldorp, Lourens

    2016-01-01

    We develop a method for estimating brain networks from fMRI datasets that have not all been measured using the same set of brain regions. Some of the coarse scale regions have been split in smaller subregions. The proposed penalized estimation procedure selects undirected graphical models with similar structures that combine information from several subjects and several coarseness scales. Both within scale edges and between scale edges that identify possible connections between a large region...

  4. Graphical Passwords Authentication: A Survey

    Nikhil Tarkeshwar Ambade; Prof. Dr. Arati Dixit

    2015-01-01

    In typically text-based passwords, well known users often create memorable passwords that are easy for attackers to guess, but strong system-assigned passwords are difficult for users to remember. Reusing same or easy passwords across different accounts help to memorability, but decrease in security. Text passwords are the most popular user authentication method, but have security and usability problems. Alternatives such as biometric systems and tokens have their own drawbacks Graphical pass...

  5. Raytracing of Virtual Graphics Scenes

    Rypák, Andrej

    2013-01-01

    This thesis is dedicated to ray tracing based rendering methods, primarily the original ray tracing. Besides introducing a brief historical overview of algorithms from the family, it presents all the essential tools, techniques and physics needed for designing a rendering application in detail. A significant part of the document consists of an implementation of a photorealistic rendering application for interactive graphics 3D virtual scenes. The focus is on rendering without u...

  6. Combinatorial Inference for Graphical Models

    Neykov, Matey; Lu, Junwei; Liu, Han

    2016-01-01

    We propose a new family of combinatorial inference problems for graphical models. Unlike classical statistical inference where the main interest is point estimation or parameter testing, combinatorial inference aims at testing the global structure of the underlying graph. Examples include testing the graph connectivity, the presence of a cycle of certain size, or the maximum degree of the graph. To begin with, we develop a unified theory for the fundamental limits of a large family of combina...

  7. Perceptual principles and computer graphics

    May, J

    2000-01-01

    Now that technology allows us to present photorealistic animations of scenically lit objects acting in realtime, the problem of computer graphics has changed fi om making displays recognisable, to ensuring that users notice what they are intended to see, without being distracted by irrelevant information. Worse than that, the use of veridical displays that are intended to be lifelike runs the risk of introducing unpredictable sources of information, that can lead users to infer all sorts of u...

  8. Antioxidant activity, cytotoxic activity and metabolic profiling of juices obtained from saffron (Crocus sativus L.) floral by-products.

    Tuberoso, Carlo I G; Rosa, Antonella; Montoro, Paola; Fenu, Maurizio Antonio; Pizza, Cosimo

    2016-05-15

    Juices obtained from cold-pressed saffron (Crocus sativus L.) floral by-products were evaluated as a potential source of compounds with antioxidant and cytotoxic activities. Floral by-products were split in two batches for extraction 24 and 48h after flower harvesting, respectively. The in vitro anti-oxidant activity of these extracts was tested using the FRAP and DPPH assays, and two biological models of lipid oxidation (activity in preventing cholesterol degradation and protection against Cu(2+)-mediated degradation of the liposomal unsaturated fatty acids). The cytotoxic activity was evaluated using the MTT assay. The results show that extracts obtained 48h post-harvest contained higher levels of total polar phenols and had the highest antioxidant activity in all of the performed assays. The LC-DAD and LC-ESI-(HR)MS(n) metabolic profiles showed high levels of kaempferol derivatives and anthocyanins. This study suggests that juices from saffron floral by-products could potentially be used to develop new products for the food and health industry. PMID:26775939

  9. An exposure:activity profiling method for interpreting high-throughput screening data for estrogenic activity--proof of concept.

    Becker, Richard A; Friedman, Katie Paul; Simon, Ted W; Marty, M Sue; Patlewicz, Grace; Rowlands, J Craig

    2015-04-01

    Rapid high throughput in vitro screening (HTS) assays are now available for characterizing dose-responses in assays that have been selected for their sensitivity in detecting estrogen-related endpoints. For example, EPA's ToxCast™ program recently released endocrine assay results for more than 1800 substances and the interagency Tox21 consortium is in the process of releasing data for approximately 10,000 chemicals. But such activity measurements alone fall short for the purposes of priority setting or screening because the relevant exposure context is not considered. Here, we extend the method of exposure:activity profiling by calculating the exposure:activity ratios (EARs) using human exposure estimates and AC50 values for a range of chemicals tested in a suite of seven estrogenic assays in ToxCast™ and Tox21. To provide additional context, relative estrogenic exposure:activity quotients (REEAQ) were derived by comparing chemical-specific EARs to the EAR of the ubiquitous dietary phytoestrogen, genistein (GEN). Although the activity of a substance in HTS-endocrine assays is not a measure of health hazard or risk, understanding how such a dose compares to human exposures provides a valuable additional metric that can be used in decision-making; substances with small EARs and REEAQs would indicate low priority for further endocrine screening or testing. PMID:25656492

  10. The profile of physical activity and coronary risk factors in Monica Jakarta survey

    Dede Kusmana

    2001-03-01

    Full Text Available A population study was done to know the profile of daily physical activity including sports, and its influence on major coronary risk factors in three districts of Jakarta using questionnaire, physicaL and laboratory examination, and 12 leads ECC. The questionnaire gave the data about physical activity (work load and sport, and smoking habit. Work load was divided into light, moderate and heavy. Sport activity was divided into regular (≥ twice a week, 20 minutes or more, irregular (≤ once or occasional, and no sport activity. In addition, blood pressure  (hypertension was grouped according to WHO criteria, total cholesterol (regarded as hypercholesterolemia when > 200 mg%, and ECG were measured. ECG interpretation was done using Minnesota Code. Statistical analysis was done using SPSS. Out of 2400 people there were  2073(86.4%  respondents that consist of 1086 females and 987 males. The profile of physical activity as a whole showed 33.4% light, 50.7% moderate and 15.8% heavy activity. OnLy 22.5% of respondents had sport regularly, while 30.3% had sport irregularly, and 47.2% had no sport activity. The type of sport was walking (45.0%, callisthenic (22.0% jogging/running (15.6%, badminton (6.5%, volley ball/soccer (4.1%, tennis (3.8%, and golf (0.1%. There was a significant difference in the prevalence of hypertension between people with heavy (12.0%, moderate (44.8% and light work load (43.2% (P<0.003, in the prevalence of hypercholesterolemia (13.2%: 50.8%: 36% (P<0.0003, and smoking (19.7%; 44.1%: 36.2% (P<0.00001, respectively. The difference also occurred in the prevalence of abnormal ECG (Q/QS, ST and T  abnormalities between people having regular sport (19.0%, irregular (22.7%, and no sport activity (58.3% (P<0.05. The number of respondents having enough physical activity (including regular sport was relatively low. Therefore, promotion should be done as a preventive method to overcome cardiovascular risk factors. (Med J Indones

  11. Graphical Classification of Entangled Qutrits

    Kentaro Honda

    2012-10-01

    Full Text Available A multipartite quantum state is entangled if it is not separable. Quantum entanglement plays a fundamental role in many applications of quantum information theory, such as quantum teleportation. Stochastic local quantum operations and classical communication (SLOCC cannot essentially change quantum entanglement without destroying it. Therefore, entanglement can be classified by dividing quantum states into equivalence classes, where two states are equivalent if each can be converted into the other by SLOCC. Properties of this classification, especially in the case of non two-dimensional quantum systems, have not been well studied. Graphical representation is sometimes used to clarify the nature and structural features of entangled states. SLOCC equivalence of quantum bits (qubits has been described graphically via a connection between tripartite entangled qubit states and commutative Frobenius algebras (CFAs in monoidal categories. In this paper, we extend this method to qutrits, i.e., systems that have three basis states. We examine the correspondence between CFAs and tripartite entangled qutrits. Using the symmetry property, which is required by the definition of a CFA, we find that there are only three equivalence classes that correspond to CFAs. We represent qutrits graphically, using the connection to CFAs. We derive equations that characterize the three equivalence classes. Moreover, we show that any qutrit can be represented as a composite of three graphs that correspond to the three classes.

  12. Graphical Language for Data Processing

    Alphonso, Keith

    2011-01-01

    A graphical language for processing data allows processing elements to be connected with virtual wires that represent data flows between processing modules. The processing of complex data, such as lidar data, requires many different algorithms to be applied. The purpose of this innovation is to automate the processing of complex data, such as LIDAR, without the need for complex scripting and programming languages. The system consists of a set of user-interface components that allow the user to drag and drop various algorithmic and processing components onto a process graph. By working graphically, the user can completely visualize the process flow and create complex diagrams. This innovation supports the nesting of graphs, such that a graph can be included in another graph as a single step for processing. In addition to the user interface components, the system includes a set of .NET classes that represent the graph internally. These classes provide the internal system representation of the graphical user interface. The system includes a graph execution component that reads the internal representation of the graph (as described above) and executes that graph. The execution of the graph follows the interpreted model of execution in that each node is traversed and executed from the original internal representation. In addition, there are components that allow external code elements, such as algorithms, to be easily integrated into the system, thus making the system infinitely expandable.

  13. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  14. Electromyographic Patterns during Golf Swing: Activation Sequence Profiling and Prediction of Shot Effectiveness.

    Verikas, Antanas; Vaiciukynas, Evaldas; Gelzinis, Adas; Parker, James; Olsson, M Charlotte

    2016-01-01

    This study analyzes muscle activity, recorded in an eight-channel electromyographic (EMG) signal stream, during the golf swing using a 7-iron club and exploits information extracted from EMG dynamics to predict the success of the resulting shot. Muscles of the arm and shoulder on both the left and right sides, namely flexor carpi radialis, extensor digitorum communis, rhomboideus and trapezius, are considered for 15 golf players (∼5 shots each). The method using Gaussian filtering is outlined for EMG onset time estimation in each channel and activation sequence profiling. Shots of each player revealed a persistent pattern of muscle activation. Profiles were plotted and insights with respect to player effectiveness were provided. Inspection of EMG dynamics revealed a pair of highest peaks in each channel as the hallmark of golf swing, and a custom application of peak detection for automatic extraction of swing segment was introduced. Various EMG features, encompassing 22 feature sets, were constructed. Feature sets were used individually and also in decision-level fusion for the prediction of shot effectiveness. The prediction of the target attribute, such as club head speed or ball carry distance, was investigated using random forest as the learner in detection and regression tasks. Detection evaluates the personal effectiveness of a shot with respect to the player-specific average, whereas regression estimates the value of target attribute, using EMG features as predictors. Fusion after decision optimization provided the best results: the equal error rate in detection was 24.3% for the speed and 31.7% for the distance; the mean absolute percentage error in regression was 3.2% for the speed and 6.4% for the distance. Proposed EMG feature sets were found to be useful, especially when used in combination. Rankings of feature sets indicated statistics for muscle activity in both the left and right body sides, correlation-based analysis of EMG dynamics and features

  15. Electromyographic Patterns during Golf Swing: Activation Sequence Profiling and Prediction of Shot Effectiveness

    Antanas Verikas

    2016-04-01

    Full Text Available This study analyzes muscle activity, recorded in an eight-channel electromyographic (EMG signal stream, during the golf swing using a 7-iron club and exploits information extracted from EMG dynamics to predict the success of the resulting shot. Muscles of the arm and shoulder on both the left and right sides, namely flexor carpi radialis, extensor digitorum communis, rhomboideus and trapezius, are considered for 15 golf players (∼5 shots each. The method using Gaussian filtering is outlined for EMG onset time estimation in each channel and activation sequence profiling. Shots of each player revealed a persistent pattern of muscle activation. Profiles were plotted and insights with respect to player effectiveness were provided. Inspection of EMG dynamics revealed a pair of highest peaks in each channel as the hallmark of golf swing, and a custom application of peak detection for automatic extraction of swing segment was introduced. Various EMG features, encompassing 22 feature sets, were constructed. Feature sets were used individually and also in decision-level fusion for the prediction of shot effectiveness. The prediction of the target attribute, such as club head speed or ball carry distance, was investigated using random forest as the learner in detection and regression tasks. Detection evaluates the personal effectiveness of a shot with respect to the player-specific average, whereas regression estimates the value of target attribute, using EMG features as predictors. Fusion after decision optimization provided the best results: the equal error rate in detection was 24.3% for the speed and 31.7% for the distance; the mean absolute percentage error in regression was 3.2% for the speed and 6.4% for the distance. Proposed EMG feature sets were found to be useful, especially when used in combination. Rankings of feature sets indicated statistics for muscle activity in both the left and right body sides, correlation-based analysis of EMG

  16. Antistaphylococcal activity and metabolite profiling of manuka honey (Leptospermum scoparium L.) after in vitro simulated digestion.

    Mannina, Luisa; Sobolev, Anatoly P; Coppo, Erika; Di Lorenzo, Arianna; Nabavi, Seyed Mohammad; Marchese, Anna; Daglia, Maria

    2016-03-16

    The antistaphylococcal activity against methicillin-susceptible and -resistant Staphylococcus aureus and the metabolite profiling of manuka honey (MH) were investigated before and after in vitro simulated gastric (GD) and gastroduodenal (GDD) digestions. Undigested manuka honey showed antibacterial activity against all the tested strains, the GD sample showed no activity against S. aureus, and the GDD honey showed an antistaphylococcal activity, which was slightly reduced in comparison with the undigested sample. To explain these results, methylglyoxal (MGO), to which most of the antibacterial activity of MH is ascribed, was subjected to in vitro simulated GD and GDD. After digestion, MGO showed antibacterial activity at concentrations definitively higher than those registered in digested MH samples. These results showed that the antistaphylococcal activity registered after digestion cannot be ascribed to MGO. Thus metabolite analysis, carried out using an explorative untargeted NMR-based approach and a targeted RP-HPLC-PAD-ESI-MSn analysis focused on bio-active substances, was used to highlight the chemical modifications occurring from digestion. The results showed that (1) the level of MGO decreases and (2) the content of aromatic compounds, such as leptosin and methyl syringate, markers of manuka honey, was stable under gastric and gastroduodenal conditions, whereas (3) the levels of acetic and lactic acids increase in particular after gastroduodenal digestion, being 1.5 and 2.8 times higher in GDD-MH than in UND-MH, respectively. Overall, the results obtained from chemical analysis provide at least a partial explanation of the registered antibacterial activity observed after gastroduodenal digestion. PMID:26948514

  17. Physiological response and activity profile in recreational small-sided football

    Randers, Morten Bredsgaard; Nielsen, Jens Jung; Bangsbo, Jens;

    2014-01-01

    We examined the effect of the number of players on the activity profile and physiological response to small-sided recreational football games with fixed relative pitch size. Twelve untrained men (age: 33.0 ± 6.4 (± standard deviation) years, fat%: 22.4 ± 6.1%, VO2 max: 43.3 ± 5.2 mL/min/kg) compl......We examined the effect of the number of players on the activity profile and physiological response to small-sided recreational football games with fixed relative pitch size. Twelve untrained men (age: 33.0 ± 6.4 (± standard deviation) years, fat%: 22.4 ± 6.1%, VO2 max: 43.3 ± 5.2 m...... accelerations (500 ± 139 vs 459 ± 143 and 396 ± 144) were higher (P < 0.05) during 3v3 than 5v5 and 7v7. In conclusion, the intensity is high during small-sided recreational football games, with similar physiological responses for 6-14 players when pitch size is adapted, providing further evidence that...... effective recreational football training is easy to organize....

  18. Inner workings of thrombolites: spatial gradients of metabolic activity as revealed by metatranscriptome profiling

    Mobberley, J. M.; Khodadad, C. L. M.; Visscher, P. T.; Reid, R. P.; Hagan, P.; Foster, J. S.

    2015-07-01

    Microbialites are sedimentary deposits formed by the metabolic interactions of microbes and their environment. These lithifying microbial communities represent one of the oldest ecosystems on Earth, yet the molecular mechanisms underlying the function of these communities are poorly understood. In this study, we used comparative metagenomic and metatranscriptomic analyses to characterize the spatial organization of the thrombolites of Highborne Cay, The Bahamas, an actively forming microbialite system. At midday, there were differences in gene expression throughout the spatial profile of the thrombolitic mat with a high abundance of transcripts encoding genes required for photosynthesis, nitrogen fixation and exopolymeric substance production in the upper three mm of the mat. Transcripts associated with denitrification and sulfate reduction were in low abundance throughout the depth profile, suggesting these metabolisms were less active during midday. Comparative metagenomics of the Bahamian thrombolites with other known microbialite ecosystems from across the globe revealed that, despite many shared core pathways, the thrombolites represented genetically distinct communities. This study represents the first time the metatranscriptome of living microbialite has been characterized and offers a new molecular perspective on those microbial metabolisms, and their underlying genetic pathways, that influence the mechanisms of carbonate precipitation in lithifying microbial mat ecosystems.

  19. Phenolic profiles and antioxidant and anticarcinogenic activities of Greek herbal infusions; balancing delight and chemoprevention?

    Kaliora, Andriana C; Kogiannou, Dimitra A A; Kefalas, Panagiotis; Papassideri, Issidora S; Kalogeropoulos, Nick

    2014-01-01

    Total phenolic content, antioxidant activity and phenolic profiles of six herbal infusions - namely rosemary, Cretan dittany, St. John's Wort, sage, marjoram and thyme were assayed. Additionally, the infusion anticarcinogenic effect as to their ability to (a) scavenge free radicals, (b) inhibit cell growth, (c) decrease IL-8 levels and (d) regulate p65 subunit in epithelial colon cancer (HT29) and prostate (PC3) cancer cells was investigated. LC-DAD-MS and GC-MS analyses showed major qualitative and quantitative differences in phenolic profiles of the infusions. All herbal infusions exhibited antiradical activity which correlated strongly with their total phenolic content. Infusions exhibited the potential to inhibit cell growth and to reduce IL-8 levels in HT29 colon and PC3 prostate cancer cells. The regulation reported in p65 subunit in HT29 treated with St John's Wort and in PC3 treated with thyme might point to the NF-κB as the molecular target underlying the effect of these infusions. PMID:24001836

  20. Physicochemical properties, fatty acid profile and antioxidant activity of peanut oil

    The oil from seeds of 4 pea nut (Arachis hypogaea L.) varieties: Golden, Bari 2000, Mongphalla, and Mongphalli 334 cultivated in arid zones, was subjected to the comparative evaluation of its physicochemical properties, fatty acid profile and antioxidant activity. Pea nut seeds were found to be a rich source of crude fat (45.09-51.63 g/100 g dry weight). The physicochemical properties of the oil were investigated as specific gravity (0.915 +-0.008-0.918+-0.008), acid value (3.96+-0.22-4.95+-0.71 mg KOH/g oil), saponification value ( 226.40+-3.59-246.56+-2.04 mg KOH/g oil) and unsaponifiable matter (3.20 +- 0.23-4.20+-0.04 g/100 g oil). The higher amounts of unsaturated fatty acids (82.06-85.93%) were found to be present in each variety. A significant variation (p<0.05) was observed among the varieties regarding crude oil content, saponification value, oleic/linoleic (O/L) ratios, phenolic acid content and total antioxidant content. Golden was found to be high in oil content, O/L ratio, antioxidant profile and DPPH scavenging activity but low in iodine value. (author)

  1. Unit 17 - Graphic Output Design Issues

    Unit 61, CC in GIS; National Center for Geographic Information and Analysis (UC Santa Barbara, SUNY at Buffalo, University of Maine)

    1990-01-01

    This unit introduces some fundamental concepts of graphic design. It discusses technical issues of label placement and general principles of graphical excellence and presents and an introduction to principles of map design.

  2. Comparing vertical profiles of natural tracers in the Williston Basin to estimate the onset of deep aquifer activation

    Hendry, M. Jim; Harrington, Glenn A.

    2014-08-01

    Comparing high-resolution depth profiles of different naturally occurring environmental tracers in aquitards should yield consistent and perhaps complementary information about solute transport mechanisms and the timing of major hydrogeological and climatological events. This study evaluated whether deep, continuous profiles of aquitard pore water chloride concentration could provide further insight into the paleohydrology of the Williston Basin, Canada, than possible using high-resolution depth profiles of stable H/O isotopes of water (δ18O, δ2H). Pore water samples were obtained from extracts of cores taken over 392 m of the thick Cretaceous shale aquitard. Water samples were also collected from wells installed in the underlying regional sandy aquifer (Mannville Group; 93 m thick) and from seepage inflows into potash mine shafts (to 825 m below ground). Numerical modeling of the 1-D vertical Cl- profile supported diffusion dominated solute transport in the shales. The modeling also showed a similar time frame for development of the Cl- profile prior to activation of the aquifer as determined from the δ18O profile (20-25 Ma); however, it provided a significantly longer and potentially better-constrained time frame for evolution of the profile during the activation phase of the aquifer (0.5-1 Ma). The dominant paleoevent reflected in present-day profiles of both tracers is the introduction of glaciogenic meteoric water to the Mannville aquifer underlying the shale during the Pleistocene. The source area of this water remains to be determined.

  3. Biological Activities and Phytochemical Profiles of Extracts from Different Parts of Bamboo (Phyllostachys pubescens

    Akinobu Tanaka

    2014-06-01

    Full Text Available Besides being a useful building material, bamboo also is a potential source of bioactive substances. Although some studies have been performed to examine its use in terms of the biological activity, only certain parts of bamboo, especially the leaves or shoots, have been studied. Comprehensive and comparative studies among different parts of bamboo would contribute to a better understanding and application of this knowledge. In this study, the biological activities of ethanol and water extracts from the leaves, branches, outer culm, inner culm, knots, rhizomes and roots of Phyllostachys pubescens, the major species of bamboo in Japan, were comparatively evaluated. The phytochemical profiles of these extracts were tentatively determined by liquid chromatography-mass spectrometry (LC-MS analysis. The results showed that extracts from different parts of bamboo had different chemical compositions and different antioxidative, antibacterial and antiallergic activities, as well as on on melanin biosynthesis. Outer culm and inner culm were found to be the most important sources of active compounds. 8-C-Glucosylapigenin, luteolin derivatives and chlorogenic acid were the most probable compounds responsible for the anti-allergy activity of these bamboo extracts. Our study suggests the potential use of bamboo as a functional ingredient in cosmetics or other health-related products.

  4. Active faults in the deformation zone off Noto Peninsula, Japan, revealed by high- resolution seismic profiles

    Inoue, T.; Okamura, Y.; Murakami, F.; Kimura, H.; Ikehara, K.

    2008-12-01

    Recently, a lot of earthquakes occur in Japan. The deformation zone which many faults and folds have concentrated exists on the Japan Sea side of Japan. The 2007 Noto Hanto Earthquake (MJMA 6.9) and 2007 Chuetsu-oki Earthquake (MJMA 6.8) were caused by activity of parts of faults in this deformation zone. The Noto Hanto Earthquake occurred on 25 March, 2007 under the northwestern coast of Noto Peninsula, Ishikawa Prefecture, Japan. This earthquake is located in Quaternary deformation zone that is continued from northern margin of Noto Peninsula to southeast direction (Okamura, 2007a). National Institute of Advanced Industrial Science and Technology (AIST) carried out high-resolution seismic survey using Boomer and 12 channels short streamer cable in the northern part off Noto Peninsula, in order to clarify distribution and activities of active faults in the deformation zone. A twelve channels short streamer cable with 2.5 meter channel spacing developed by AIST and private corporation is designed to get high resolution seismic profiles in shallow sea area. The multi-channel system is possible to equip on a small fishing boat, because the data acquisition system is based on PC and the length of the cable is short and easy to handle. Moreover, because the channel spacing is short, this cable is very effective for a high- resolution seismic profiling survey in the shallow sea, and seismic data obtained by multi-channel cable can be improved by velocity analysis and CDP stack. In the northern part off Noto Peninsula, seismic profiles depicting geologic structure up to 100 meters deep under sea floor were obtained. The most remarkable reflection surface recognized in the seismic profiles is erosion surface at the Last Glacial Maximum (LGM). In the western part, sediments about 30 meters (40 msec) thick cover the erosional surface that is distributed under the shelf shallower than 100m in depth and the sediments thin toward offshore and east. Flexures like deformation in

  5. Computer graphics from basic to application

    This book mentions conception of computer graphics, background history, necessity and applied field like construction design, image processing, auto mobile design, fashion design and TV broadcast, basic principle of computer, computer graphics hardware, computer graphics software such as adobe illustrator tool box and adobe photo shop, quarkXpress like introduction, application and operating circumstance, 3D graphics with summary, difference of versions of 3D studio and system, and Auto CAD application.

  6. Towards art content in original graphic arts

    Grdina, Sonja

    2011-01-01

    Contemporary Graphic art defines numerous graphic art techniques; from classical original graphic art techniques to the new media techniques. The new media reproduction and communication capacity influences contemporary art works in such way that more attention is on non-artistic content, while artistic content with its visual efficiency becomes less important. Reproductibility is one of the non-artistic contents which plays a key role in original graphic arts, where it is a means of making o...

  7. Introduction to Graphics Programming in Java

    Rosendahl, Mads

    Writing graphics applications in Java using Swing can be quite a daunting experience which requires understanding of some large libraries, and fairly advanced aspects of Java. In these notes we will show that by using a small subset of the Swing package we can write a write range of graphics...... programs. To make this possible we have constructed three small classes that simplifies three of the more complex aspects of graphics programming: 2D-graphics, layout of components, and event-handling....

  8. Data structures, computer graphics, and pattern recognition

    Klinger, A; Kunii, T L

    1977-01-01

    Data Structures, Computer Graphics, and Pattern Recognition focuses on the computer graphics and pattern recognition applications of data structures methodology.This book presents design related principles and research aspects of the computer graphics, system design, data management, and pattern recognition tasks. The topics include the data structure design, concise structuring of geometric data for computer aided design, and data structures for pattern recognition algorithms. The survey of data structures for computer graphics systems, application of relational data structures in computer gr

  9. Concept graphics: a language for medical knowledge.

    Preiss, B.; Kaltenbach, M; Zanazaka, J.; Echave, V

    1992-01-01

    This paper makes a case for Concept Graphics, a novel form of medical knowledge representation. Concept Graphics are assemblies of icons each of which has a precise meaning. Individual icons are metaphors of the object or process they represent. Concept Graphics are analogs of pathological situations, their symptoms, signs and other relevant components necessary for a diagnosis. We propose three principal areas of application for Concept Graphics: medical education, medical records management...

  10. Lean mainstream schemes for Stata 8 graphics

    Juul, Svend

    2003-01-01

    The new Stata 8 graphics are powerful and flexible. Now, a few months after the first release, the graphics still have some shortcomings—both in design and in the manual documenting the program—but progress is being made. The graph layout used throughout the Graphics Reference Manual has led some...

  11. Information Graphic Classification, Decomposition and Alternative Representation

    Gao, Jinglun

    2012-01-01

    This thesis work is mainly focused on two problems related to improving accessibility of information graphics for visually impaired users. The first problem is automated analysis of information graphics for information extraction and the second problem is multi-modal representations for accessibility. Information graphics are graphical…

  12. Graphic Design Is Not a Medium.

    Gruber, John Edward, Jr.

    2001-01-01

    Discusses graphic design and reviews its development from analog processes to a digital tool with the use of computers. Topics include graphical user interfaces; the need for visual communication concepts; transmedia as opposed to repurposing; and graphic design instruction in higher education. (LRW)

  13. Seismic data catalog and associated graphical capabilities

    Bishop, T.N.; Foote, H.P.; Blair, S.C.

    1979-11-01

    To facilitate the use of the enormous amount of earthquake data presently available, Pacific Northwest Laboratory (PNL) formed an extensive data base of compiled seismic data. PNL also developed many useful and unique computer techniques for analysis and display of the data. These techniques could be used in many areas of the United States to support nuclear waste management and other energy-related activities. Software associated with the data base includes programs for editing earthquake files; sorting files with respect to time, location, or magnitude; selecting data by use of various parameters; and merging files. These techniques allow the rapid formation of data files that are tailored to specific interests. The desired file may then be listed or displayed graphically by means of PNL's diversified graphic capability. From the data analysis software, an accurate and comprehensive earthquake catalog for the Pacific Northwest was created. This catalog was produced by merging data from many sources and includes microearthquake data. Duplicate events were eliminated, while all information available for a particular event was retained. Graphic displays can plot two- and three-dimensional epicenter or hypocenter information. Magnitude and/or depth information can be represented on two-dimensional plots by using color or symbol size. Plots can be produced using a variety of map projections and at a specified scale. This capability allows the use of any desired map as a base map for the display of earthquake data. Additional information such as rivers, coastlines, faults, and boundaries may also be included on the plots. Data may also be displayed using normal or two-dimensional histograms. 19 figures, 7 tables.

  14. JET steady state ITB operation with active control of the pressure profile

    Stationary operations have been achieved at JET in ITBs scenarios, with the discharge time limited only by plant constraints. Full current drive was obtained, all over the high performance phase, with the current density profile frozen by using Lower Hybrid current drive. For the first time a feed-back control on the total pressure and on the electron temperature profile was implemented by using respectively the Neutral Beams and the Ion Cyclotron waves. Although impurity accumulation could be a problem in steady state ITBs, these experiments bring some elements to answer to it. Tokamak operation in enhanced confinement regimes, characterized by edge and/or Internal Transport Barriers (respectively known as H-mode and ITB), is attractive as it represents an important step towards the approach of ignition conditions. Moreover, the necessity of steady state operation in a Tokamak reactor, has led to the concept of the Advanced Tokamak, in which the current density profile is no longer tied to the plasma conductivity and is non inductively driven. Since the bootstrap current is a consequence of the pressure gradient, one of the primary goal of the Advanced Tokamak studies is to maximize the bootstrap fraction, with a proper alignment, both in H mode and in ITB regimes. However, for several reasons, it is difficult to envisage an operational situation in which the bootstrap fraction is close to 100%: for instance, there are few chances of pressure or/and current profile control to optimize the MHD stability. So far, various experiments have been performed with improved confinement regimes lasting up to tens of the confinement time and up to some current relaxation times. In some experiments a large non inductive plasma current (< 75%) was obtained with about 50% from bootstrap and 25% from Neutral Beam Injection (NBI); however, no full current drive operation was achieved and, moreover, with the available heating systems, no active feedback control of the current

  15. Combined tomographic forward and inverse modeling of active seismic refraction profiling data

    Koulakov, I.; Kopp, H.

    2008-12-01

    We present a new code for combined forward and inverse tomographic modeling based on first-arrival travel times of active seismic refraction profiling data (PROFIT - Profile Forward and Inverse Tomographic modeling). The main features of the algorithm involve the original version of bending ray tracing, parameterization based on nodes, variable grid size definition determined by the ray density, and regularization of the inversion. The key purpose of applying the PROFIT code is rather not in solely producing the tomographic image of a continuous velocity field, but in creating a geologically reasonable synthetic model. This model then includes first-order velocity changes representing petrophysical boundaries and is thus better suited for a geological-tectonic interpretation than its smoothed tomographic counterpart. After performing forward and inverse modeling, the synthetic model will reproduce a congeneric model to the tomographic inversion result of the observed data. We demonstrate the working ability of the code using two marine datasets acquired in the Musicians Seamount Province (Pacific Ocean). The results of the tomographic inversion clearly resolve the dominating extrusive volcanism. In addition, the combined forward and inverse approach tests a large variety of synthetic models to fit the observed data tomography. Along both profiles, the preferred structural model includes a strong positive velocity anomaly extending into the seamount edifice. We suggest that this anomaly pattern represents secondary intrusive processes, which are only revealed by the combined tomographic forward and inverse modeling and could not be resolved by exclusively applying a tomographic inversion. In addition, we present examples of imaging salt domes in the Precaspian oil province as well as a higher-resolution field study that was conducted as a preinvestigative study for tunnel construction to demonstrate the capability of the code in different regimes and on different

  16. Phytochemical Profiles and Antioxidant and Antimicrobial Activities of the Leaves of Zanthoxylum bungeanum

    Yujuan Zhang

    2014-01-01

    Full Text Available The ethanol crude extracts (ECE and their subfractions from Zanthoxylum bungeanum leaves were prepared and their phytochemical profiles and antioxidant and antimicrobial activities were investigated. Moreover, the effective HPLC procedure for simultaneous quantification of twelve compounds in Z. bungeanum leaves was established. The correlation between the phytochemicals and antioxidant activity was also discussed. The ethyl acetate fraction (EAF had the highest total phenolic (97.29 mmol GAE/100 g and flavonoid content (67.93 mmol QE/100 g, while the greatest total alkaloid content (4.39 mmol GAE/100 g was observed in the chloroform fraction (CF. Twelve compounds were quantified by RP-HPLC assay. EAF exhibited the highest content of quercitrin, kaempferol-3-rhamnoside, quercetin, sesamin, and nitidine chloride (125.21, 54.95, 24.36, 26.24, and 0.20 mg/g; acetone fraction (AF contained the highest content of chlorogenic acid, rutin, hyperoside, and trifolin (5.87, 29.94, 98.33, and 31.24 mg/g, while kaempferol-3-rhamnoside, xanthyletin, and sesamin were rich in CF. EAF and AF exhibited significant DPPH, ABTS radical scavenging abilities and reducing power (FRAP, whereas CF exhibited significant antifungal activity. Moreover, EAF also showed stronger antibacterial activity. In conclusion, Z. bungeanum leaves have health benefits when consumed and could be served as an accessible source for production of functional food ingredients and medicinal exploration.

  17. Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni.

    Gordana Panic

    Full Text Available As plans to expand mass drug treatment campaigns to fight schistosomiasis form, worries about reliance on praziquantel as the sole available treatment motivate the investigation for novel antischistosomal compounds. Drug repurposing might be an inexpensive and effective source of novel antischistosomal leads.1600 FDA approved compounds were first assayed against Schistosoma mansoni schistosomula at a concentration of 10 µM. Active compounds identified from this screen were advanced to the adult worm screen at 33.33 µM, followed by hit characterization. Leads with complementary pharmacokinetic and toxicity profiles were then selected for in vivo studies.The in vitro screen identified 121 and 36 compounds active against the schistosomula and adult stage, respectively. Further, in vitro characterization and comparison with already available pharmacokinetic and toxicity data identified 11 in vivo candidates. Doramectin (10 mg/kg and clofazimine (400 mg/kg were found to be active in vivo with worm burden reductions of 60.1% and 82.7%, respectively.The work presented here expands the knowledge of antischistosomal properties of already approved compounds and underscores variations observed between target-based and phenotypic approaches and among laboratories. The two in vivo-active drugs identified in this study, doramectin and clofazimine are widely available and present as novel drug classes as starting points for further investigation.

  18. Variability in HOMA-IR, Lipoprotein Profile and Selected Hormones in Young Active Men

    Lutoslawska, Grazyna; Czajkowska, Anna; Tkaczyk, Joanna; Mazurek, Krzysztof

    2013-01-01

    Resistance to insulin actions is contributing to many metabolic disturbances. Such factors as age, sex, nutrition, body fat, and physical activity determine body insulin resistance. Present study attempted to asses insulin resistance and its metabolic effects with respect to energy intake in young, lean, and active men. A total of 87 men aged 18–23 participated in the study. Plasma levels of glucose, insulin, lipoproteins, cortisol, and TSH were determined. Insulin resistance was expressed as Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and calculated using homeostatic model. The median value of HOMA-IR (1.344) was used to divide subjects into two groups. Men did not differ in anthropometric parameters, daily physical activity, and plasma TSH and cortisol levels. However, in men with higher HOMA-IR significantly lower daily energy intake was observed concomitantly with higher TG, TC, and HDL-C concentrations in plasma versus their counterparts with lower HOMA-IR. Exclusively in subjects with higher HOMA-IR significant and positive correlation was noted between HOMA-IR and TC and LDL-C. We concluded that despite a normal body weight and physical activity, a subset of young men displayed unfavorable changes in insulin sensitivity and lipid profile, probably due to insufficient energy intake. PMID:24348155

  19. Antimicrobial activity and composition profile of grape (Vitis vinifera) pomace extracts obtained by supercritical fluids.

    Oliveira, Daniela A; Salvador, Ana Augusta; Smânia, Artur; Smânia, Elza F A; Maraschin, Marcelo; Ferreira, Sandra R S

    2013-04-10

    The possibility of increasing the aggregated value of the huge amount of residues generated by wineries around the world foment studies using the grape pomace - the residue from the wine production, composed by seed, skin and stems - to obtain functional ingredients. Nowadays, consumers in general prefer natural and safe products mainly for food and cosmetic fields, where the supercritical fluid extraction is of great importance due to the purity of the extracts provided. Therefore, the objective of this work is to evaluate the global extraction yield, the antimicrobial activity and the composition profile of Merlot and Syrah grape pomace extracts obtained by supercritical CO2 (SC-CO2) and CO2 added with co-solvent at pressures up to 300 bar and temperatures of 50 and 60 °C. The results were compared with the ones obtained by Soxhlet and by ultrasound-assisted leaching extraction methods. The main components from the extracts, identified by HPLC, were gallic acid, p-OH-benzoic acid, vanillic acid and epicatechin. The antibacterial and antifungal activities of the extracts were evaluated using four strains of bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa) and three fungi strains (Candida albicans, Candida parapsilosis, Candida krusei). Despite lower extraction yield results, the supercritical fluid extracts presented the highest antimicrobial effectiveness compared to the other grape pomace extracts due to the presence of antimicrobial active compounds. Syrah extracts were less efficient against the microorganisms tested and Merlot extracts were more active against Gram-positive bacteria. PMID:23036924

  20. Phytochemical profiles and antioxidant and antimicrobial activities of the leaves of Zanthoxylum bungeanum.

    Zhang, Yujuan; Luo, Ziwen; Wang, Dongmei; He, Fengyuan; Li, Dengwu

    2014-01-01

    The ethanol crude extracts (ECE) and their subfractions from Zanthoxylum bungeanum leaves were prepared and their phytochemical profiles and antioxidant and antimicrobial activities were investigated. Moreover, the effective HPLC procedure for simultaneous quantification of twelve compounds in Z. bungeanum leaves was established. The correlation between the phytochemicals and antioxidant activity was also discussed. The ethyl acetate fraction (EAF) had the highest total phenolic (97.29 mmol GAE/100 g) and flavonoid content (67.93 mmol QE/100 g), while the greatest total alkaloid content (4.39 mmol GAE/100 g) was observed in the chloroform fraction (CF). Twelve compounds were quantified by RP-HPLC assay. EAF exhibited the highest content of quercitrin, kaempferol-3-rhamnoside, quercetin, sesamin, and nitidine chloride (125.21, 54.95, 24.36, 26.24, and 0.20 mg/g); acetone fraction (AF) contained the highest content of chlorogenic acid, rutin, hyperoside, and trifolin (5.87, 29.94, 98.33, and 31.24 mg/g), while kaempferol-3-rhamnoside, xanthyletin, and sesamin were rich in CF. EAF and AF exhibited significant DPPH, ABTS radical scavenging abilities and reducing power (FRAP), whereas CF exhibited significant antifungal activity. Moreover, EAF also showed stronger antibacterial activity. In conclusion, Z. bungeanum leaves have health benefits when consumed and could be served as an accessible source for production of functional food ingredients and medicinal exploration. PMID:25147836

  1. Expression profile of heat shock response factors during hookworm larval activation and parasitic development.

    Gelmedin, Verena; Delaney, Angela; Jennelle, Lucas; Hawdon, John M

    2015-07-01

    When organisms are exposed to an increase in temperature, they undergo a heat shock response (HSR) regulated by the transcription factor heat shock factor 1 (HSF-1). The heat shock response includes the rapid changes in gene expression initiated by binding of HSF-1 to response elements in the promoters of heat shock genes. Heat shock proteins function as molecular chaperones to protect proteins during periods of elevated temperature and other stress. During infection, hookworm infective third stage larvae (L3) undergo a temperature shift from ambient to host temperature. This increased temperature is required for the resumption of feeding and activation of L3, but whether this increase initiates a heat shock response is unknown. To investigate the role of the heat shock in hookworm L3 activation and parasitic development, we identified and characterized the expression profile of several components of the heat shock response in the hookworm Ancylostoma caninum. We cloned DNAs encoding an hsp70 family member (Aca-hsp-1) and an hsp90 family member (Aca-daf-21). Exposure to a heat shock of 42°C for one hour caused significant up-regulation of both genes, which slowly returned to near baseline levels following one hour attenuation at 22°C. Neither gene was up-regulated in response to host temperature (37°C). Conversely, levels of hsf-1 remained unchanged during heat shock, but increased in response to incubation at 37°C. During activation, both hsp-1 and daf-21 are down regulated early, although daf-21 levels increase significantly in non-activated control larvae after 12h, and slightly in activated larvae by 24h incubation. The heat shock response modulators celastrol and KNK437 were tested for their effects on gene expression during heat shock and activation. Pre-incubation with celastrol, an HSP90 inhibitor that promotes heat shock gene expression, slightly up-regulated expression of both hsp-1 and daf-21 during heat shock. KNK437, an inhibitor of heat shock

  2. Active and Passive Microwave Retrieval Algorithm for Hydrometeor Concentration Profiles: Application to the HAMP Instrument

    Orlandi, E.; Mech, M.; Crewell, S.; Lammert, A.

    2012-12-01

    Clouds and precipitation play an important role in the atmospheric water cycle and radiation budget. Unfortunately, the understanding of the processes involved in cloud and precipitation formation and their description in global and regional models are still poor. To improve our understanding of these processes and to reduce model uncertainties, new observation and retrieval techniques are needed. The upcoming Global Precipitation Mission (GPM) provides a combination of a 36 GHz cloud radar and a suite of passive microwave instruments. In the retrieval development process for this and other upcoming missions, airborne platforms are a useful tool to test the algorithms exploiting the synergy of active and passive microwave instruments, and to validate satellite retrievals. In this respect HAMP (Microwave Package for HALO, the High Altitude Long Range aircraft), consisting of a 36 GHz Doppler cloud radar and a 26-channel radiometer, is an ideal test-bed. HAMP radiometers have frequencies along absorption lines (22, 60, 118 and 183 GHz) and in window regions, overlapping with those of AMSU A and B. HAMP will participate in early 2013 in the dedicated remote sensing HALO mission NARVAL (Next-generation Aircraft Remote-sensing for VALidation studies). During NARVAL, the HALO payload will include a water vapor lidar and drop sondes in addition to HAMP. The NARVAL campaign will thus be a excellent opportunity to test a newly developed retrieval algorithm, which exploits the synergy between passive and active microwave observations. In this work we present a Bayesian algorithm to retrieve precipitation rate, liquid and frozen hydrometeor concentration, as well as temperature and humidity profiles from the synergetic use of active and passive microwave nadir observations. Temperature and humidity are derived solely from passive radiometer measurements while the combined cloud radar and radiometer observations are used to retrieve hydrometeor concentration profiles. Lidar

  3. Protein profiling and histone deacetylation activities in somaclonal variants of oil palm (Elaeis guineensis Jacq.).

    Yaacob, Jamilah Syafawati; Loh, Hwei-San; Mat Taha, Rosna

    2013-01-01

    Mantled fruits as a result of somaclonal variation are often observed from the oil palm plantlets regenerated via tissue culture. The mantling of fruits with finger-like and thick outer coating phenotypes significantly reduces the seed size and oil content, posing a threat to oil palm planters, and may jeopardize the economic growth of countries that depend particularly on oil palm plantation. The molecular aspects of the occurrence of somaclonal variations are yet to be known, possibly due to gene repression such as DNA methylation, histone methylation and histone deacetylation. Histone deacetylases (HDACs), involved in eukaryotic gene regulation by catalyzing the acetyl groups are removal from lysine residues on histone, hence transcriptionally repress gene expression. This paper described the total protein polymorphism profiles of somaclonal variants of oil palm and the effects of histone deacetylation on this phenomenon. Parallel to the different phenotypes, the protein polymorphism profiles of the mantled samples (leaves, fruits, and florets) and the phenotypically normal samples were proven to be different. Higher HDAC activity was found in mantled leaf samples than in the phenotypically normal leaf samples, leading to a preliminary conclusion that histone deacetylation suppressed gene expression and contributed to the development of somaclonal variants. PMID:23844406

  4. Metabolic profiles and free radical scavenging activity of Cordyceps bassiana fruiting bodies according to developmental stage.

    Sun-Hee Hyun

    Full Text Available The metabolic profiles of Cordyceps bassiana according to fruiting body developmental stage were investigated using gas chromatography-mass spectrometry. We were able to detect 62 metabolites, including 48 metabolites from 70% methanol extracts and 14 metabolites from 100% n-hexane extracts. These metabolites were classified as alcohols, amino acids, organic acids, phosphoric acids, purine nucleosides and bases, sugars, saturated fatty acids, unsaturated fatty acids, or fatty amides. Significant changes in metabolite levels were found according to developmental stage. Relative levels of amino acids, purine nucleosides, and sugars were higher in development stage 3 than in the other stages. Among the amino acids, valine, isoleucine, lysine, histidine, glutamine, and aspartic acid, which are associated with ABC transporters and aminoacyl-tRNA biosynthesis, also showed higher levels in stage 3 samples. The free radical scavenging activities, which were significantly higher in stage 3 than in the other stages, showed a positive correlation with purine nucleoside metabolites such as adenosine, guanosine, and inosine. These results not only show metabolic profiles, but also suggest the metabolic pathways associated with fruiting body development stages in cultivated C. bassiana.

  5. Protein Profiling and Histone Deacetylation Activities in Somaclonal Variants of Oil Palm (Elaeis guineensis Jacq.

    Jamilah Syafawati Yaacob

    2013-01-01

    Full Text Available Mantled fruits as a result of somaclonal variation are often observed from the oil palm plantlets regenerated via tissue culture. The mantling of fruits with finger-like and thick outer coating phenotypes significantly reduces the seed size and oil content, posing a threat to oil palm planters, and may jeopardize the economic growth of countries that depend particularly on oil palm plantation. The molecular aspects of the occurrence of somaclonal variations are yet to be known, possibly due to gene repression such as DNA methylation, histone methylation and histone deacetylation. Histone deacetylases (HDACs, involved in eukaryotic gene regulation by catalyzing the acetyl groups are removal from lysine residues on histone, hence transcriptionally repress gene expression. This paper described the total protein polymorphism profiles of somaclonal variants of oil palm and the effects of histone deacetylation on this phenomenon. Parallel to the different phenotypes, the protein polymorphism profiles of the mantled samples (leaves, fruits, and florets and the phenotypically normal samples were proven to be different. Higher HDAC activity was found in mantled leaf samples than in the phenotypically normal leaf samples, leading to a preliminary conclusion that histone deacetylation suppressed gene expression and contributed to the development of somaclonal variants.

  6. Graphic Design: Now in Production

    Thorel, Benjamin

    2012-01-01

    Catalogue d’une imposante exposition co-organisée par le Walker Art Center de Minneapolis et le National Design Museum Cooper-Hewitt de New York, Graphic Design : Now in Production ambitionne de cartographier les territoires du design graphique contemporain dans son acception la plus large possible. Identité visuelle, magazines, posters, typographie, webdesign ou génériques de films sont abordés dans cet ouvrage particulièrement dense. Des planches illustrées, agrémentées de commentaires, ren...

  7. Wang Tiles in Computer Graphics

    Lagae, Ares

    2009-01-01

    Many complex signals in computer graphics, such as point distributions and textures, cannot be efficiently synthesized and stored. This book presents tile-based methods based on Wang tiles and corner tiles to solve both these problems. Instead of synthesizing a complex signal when needed, the signal is synthesized beforehand over a small set of Wang tiles or corner tiles. Arbitrary large amounts of that signal can then efficiently be generated when needed by generating a stochastic tiling, and storing only a small set of tiles reduces storage requirements. A tile-based method for generating a

  8. HISPLT: A history graphics postprocessor

    HISPLT is a graphics postprocessor designed to plot time histories for wave propagation codes. HISPLT is available for CRAY UNICOS, CRAY CTSS, VAX VMS computer systems, and a variety of UNIX workstations. The original HISPLT code employs a database structure that allows the program to be used without modification to process data generated by many wave propagation codes. HISPLT has recently been modified to process time histories for the reactor safety analysis code, MELCOR. This report provides a complete set of input instructions for HISPLT and provides examples of the types of plotted output that can be generated using HISPLT. 6 refs., 8 figs., 5 tabs

  9. Graphic utilities 'GPREP' and 'LIBGR'

    Plotting utilities, which are widely appreciable to problems of computational physics, have been developed as a part of a library system for a one dimensional tokamak transport code. Utility routines are composed of two procedures, i.e., the pre-processor ''GPREP'' registrates graphic data to a data file with a set format, and ''LIBGR'' processes the data to match with the required format of ''ARGUS'' and plotts the graph. The regular form of data by ''GPREP'' enables us to read out data without any information on data recording so that these utilities are very usefull for dealing with a lot of disorder data with different type. (author)

  10. Graphic Presentation: An Empirical Examination of the Graphic Novel Approach to Communicate Business Concepts

    Short, Jeremy C.; Randolph-Seng, Brandon; McKenny, Aaron F.

    2013-01-01

    Graphic novels have been increasingly incorporated into business communication forums. Despite potential benefits, little research has examined the merits of the graphic novel approach. In response, we engage in a two-study approach. Study 1 explores the potential of graphic novels to affect learning outcomes and finds that the graphic novel was…

  11. A handbook of statistical graphics using SAS ODS

    Der, Geoff

    2014-01-01

    An Introduction to Graphics: Good Graphics, Bad Graphics, Catastrophic Graphics and Statistical GraphicsThe Challenger DisasterGraphical DisplaysA Little History and Some Early Graphical DisplaysGraphical DeceptionAn Introduction to ODS GraphicsGenerating ODS GraphsODS DestinationsStatistical Graphics ProceduresODS Graphs from Statistical ProceduresControlling ODS GraphicsControlling Labelling in GraphsODS Graphics EditorGraphs for Displaying the Characteristics of Univariate Data: Horse Racing, Mortality Rates, Forearm Lengths, Survival Times and Geyser EruptionsIntroductionPie Chart, Bar Cha

  12. Effect of seafood mediated PCB exposure on desaturase activity and PUFA profile in Faroese septuagenarians

    Tøttenborg, Sandra Søgaard; Choi, Anna L; Bjerve, Kristian S;

    2015-01-01

    Polychlorinated biphenyl (PCB) exposure may affect serum concentrations of polyunsaturated fatty acids (PUFAs) by inhibiting desaturases ∆5 and ∆6 that drive their synthesis from precursor fatty acids. Such changes in the composition of fatty acids may affect cardiovascular disease risk, which is...... thought to increase at elevated PCB exposures. This population-based cross-sectional study examined 712 Faroese men and women aged 70-74 years. The serum phospholipid fraction of fasting blood samples was used to determine the PUFA profile, including linoleic acid, dihomo-γ-linolenic acid, arachidonic...... acid, eicosatrienoic acid, and other relevant fatty acids. Ratios between precursor and metabolite fatty acids were used as proxies for ∆5 and ∆6 desaturase activity. Tertiles of serum-PCB concentrations were used in multiple regression analyses to determine the association between the exposure and...

  13. Multi-elemental profile of some Brazilian make-up products by instrumental neutron activation analysis

    Recent works have shown that analysis in cosmetics and beauty products from the European and Asian markets indicate the presence of U, Th and rare earths besides other trace elements. Considering these previous findings and health issues, it would be valuable to obtain information on elements in cosmetics available in the Brazilian market. The purpose of this study was to acquire a multi-elemental profile of some Brazilian make-up products of diverse brands. Samples of eye shadow, liquid base, facial concealer, lipstick, and compact face powder were analyzed applying neutron activation analysis, k0-standardization method at CDTN/CNEN, using the TRIGA Mark I IPR-R1 research reactor. Concentrations of more than 30 elements in samples are presented and it was found elements included in Brazilian National Health Surveillance Agency prohibitive list, rare earths, Th and U in a minimum of two cosmetic samples. (author)

  14. Gene expression profiling of porcine skeletal muscle in the early recovery phase following acute physical activity

    Hansen, Jeanette; Conley, Lene; Hedegaard, Jakob; Nielsen, Mathilde; Young, Jette F; Oksbjerg, Niels; Hornshøj, Henrik; Bendixen, Christian; Thomsen, Bo

    2012-01-01

    Acute physical activity elicits changes in gene expression in skeletal muscles to promote metabolic changes and to repair exercise-induced muscle injuries. In the present time-course study, pigs were submitted to an acute bout of treadmill running until near exhaustion to determine the impact of...... associated with proteolytic events, such as the muscle-specific E3 ubiquitin ligase atrogin-1, were significantly upregulated, suggesting that protein breakdown, prevention of protein aggregation and stabilization of unfolded proteins are important processes for restoration of cellular homeostasis. We also...... unaccustomed exercise on global transcriptional profiles in porcine skeletal muscles. Using a combined microarray and candidate gene approach, we identified a suite of genes that are differentially expressed in muscles during postexercise recovery. Several members of the heat shock protein family and proteins...

  15. Multi-elemental profile of some Brazilian make-up products by instrumental neutron activation analysis

    Dalmazio, Ilza; Menezes, Maria Angela de B.C., E-mail: id@cdtn.b, E-mail: menezes@cdtn.b [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil). Servico de Reator e Tecnicas Analiticas. Lab. de Ativacao Neutronica

    2011-07-01

    Recent works have shown that analysis in cosmetics and beauty products from the European and Asian markets indicate the presence of U, Th and rare earths besides other trace elements. Considering these previous findings and health issues, it would be valuable to obtain information on elements in cosmetics available in the Brazilian market. The purpose of this study was to acquire a multi-elemental profile of some Brazilian make-up products of diverse brands. Samples of eye shadow, liquid base, facial concealer, lipstick, and compact face powder were analyzed applying neutron activation analysis, k{sub 0}-standardization method at CDTN/CNEN, using the TRIGA Mark I IPR-R1 research reactor. Concentrations of more than 30 elements in samples are presented and it was found elements included in Brazilian National Health Surveillance Agency prohibitive list, rare earths, Th and U in a minimum of two cosmetic samples. (author)

  16. Analysis of whey protein hydrolysates: peptide profile and ACE inhibitory activity

    Marialice Pinto Coelho Silvestre

    2012-12-01

    Full Text Available The aim of this study was to prepare enzymatic hydrolysates from whey protein concentrate with a nutritionally adequate peptide profile and the ability to inhibit angiotensin-converting enzyme (ACE activity. The effects of the type of enzyme used (pancreatin or papain, the enzyme:substrate ratio (E:S ratio=0.5:100, 1:100, 2:100 and 3:100 and the use of ultrafiltration (UF were investigated. The fractionation of peptides was performed by size-exclusion-HPLC, and the quantification of the components of the chromatographic fractions was carried out by a rapid Corrected Fraction Area method. The ACE inhibitory activity (ACE-IA was determined by Reverse Phase-HPLC. All parameters tested affected both the peptide profile and the ACE-IA. The best peptide profile was achieved for the hydrolysates obtained with papain, whereas pancreatin was more advantageous in terms of ACE-IA. The beneficial effect of using a lower E:S ratio on the peptide profile and ACE-IA was observed for both enzymes depending on the conditions used to prepare the hydrolysates. The beneficial effect of not using UF on the peptide profile was observed in some cases for pancreatin and papain. However, the absence of UF yielded greater ACE-IA only when using papain.O objetivo deste estudo foi preparar hidrolisados enzimáticos do concentrado proteico do soro de leite com perfil peptídico nutricionalmente adequado e com capacidade para inibir a atividade da enzima conversora da angiotensina (ECA. Os efeitos do tipo de enzima usado (pancreatina ou papaína, da relação enzima:substrato (E:S=0,5:100, 1:100, 2:100 e 3:100 e do uso da ultrafiltração (UF foram investigados. O fracionamento dos peptídeos foi feito por CLAE de exclusão molecular e a quantificação dos componentes das frações cromatográficas foi realizada pelo método da Área Corrigida da Fração. A atividade inibitória da ECA (AI-ECA foi determinada por CLAE de fase reversa. Todos os parâmetros testados afetaram

  17. MicroRNA Profiling of Activated and Tolerogenic Human Dendritic Cells

    Zuzana Stumpfova

    2014-01-01

    Full Text Available Dendritic cells (DCs belong to the immune system and are particularly studied for their potential to direct either an activated or tolerogenic immune response. The roles of microRNAs (miRNAs in posttranscriptional gene expression regulation are being increasingly investigated. This study’s aim is to evaluate the miRNAs’ expression changes in prepared human immature (iDCs, activated (aDCs, and tolerogenic dendritic cells (tDCs. The dendritic cells were prepared using GM-CSF and IL-4 (iDC and subsequently maturated by adding LPS and IFN-γ (aDC or IL-10 and TGF-β (tDC. Surface markers, cytokine profiles, and miRNA profiles were evaluated in iDC, tDC, and aDC at 6 h and 24 h of maturation. We identified 4 miRNAs (miR-7, miR-9, miR-155 and miR-182, which were consistently overexpressed in aDC after 6 h and 24 h of maturation and 3 miRNAs (miR-17, miR-133b, and miR-203 and miR-23b cluster solely expressed in tDC. We found 5 miRNAs (miR-10a, miR-203, miR-210, miR-30a, and miR-449b upregulated and 3 miRNAs downregulated (miR-134, miR-145, and miR-149 in both tDC and aDC. These results indicate that miRNAs are specifically modulated in human DC types. This work may contribute to identifying specific modulating miRNAs for aDC and tDC, which could in the future serve as therapeutic targets in the treatment of cancer and autoimmune diseases.

  18. Antioxidant activity and phenolic profiles of the wild currant Ribes magellanicum from Chilean and Argentinean Patagonia.

    Jiménez-Aspee, Felipe; Thomas-Valdés, Samanta; Schulz, Ayla; Ladio, Ana; Theoduloz, Cristina; Schmeda-Hirschmann, Guillermo

    2016-07-01

    The Patagonian currant Ribes magellanicum is highly valued due to its pleasant flavor and sweet taste. The aim of this study was to characterize its constituents and to assess their antioxidant and cytoprotective properties. For the fruit phenolic-enriched extract (PEE), total phenolics (TP), total flavonoids (TF), and antioxidant activity (DPPH, Ferric reducing antioxidant power (FRAP), and Trolox equivalent antioxidant activity (TEAC)) were determined. Argentinean samples presented better activity in the DPPH and FRAP assays. Best cytoprotection against oxidative stress induced by H2O2 in AGS cells was found in one Argentinean sample at 500 μg mL(-1) (65.7%). HPLC MS/MS analysis allowed the tentative identification of 59 constituents, including eight anthocyanins, 11 conjugates of caffeic-, ferulic-, and coumaric acid, and 38 flavonoids, most of them quercetin and kaempferol derivatives. Argentinean samples showed a more complex pattern of anthocyanins, hydroxycinnamic acids (HCA), and flavonoids. Cyanidin rhamnoside hexoside and cyanidin hexoside were the main anthocyanins, accounting for 35 and 55% for the Argentinean and 60 and 27% for the ripe Chilean fruits. HCA content was about three times higher in Argentinean samples. The phenolic profiles of Chilean and Argentinean Ribes magellanicum show remarkable differences in chemical composition with higher HCA and flavonoid content in Argentinean samples. PMID:27386109

  19. Profiling Physical Activity, Diet, Screen and Sleep Habits in Portuguese Children

    Sara Pereira

    2015-06-01

    Full Text Available Obesity in children is partly due to unhealthy lifestyle behaviours, e.g., sedentary activity and poor dietary choices. This trend has been seen globally. To determine the extent of these behaviours in a Portuguese population of children, 686 children 9.5 to 10.5 years of age were studied. Our aims were to: (1 describe profiles of children’s lifestyle behaviours; (2 identify behaviour pattern classes; and (3 estimate combined effects of individual/ socio-demographic characteristics in predicting class membership. Physical activity and sleep time were estimated by 24-h accelerometry. Nutritional habits, screen time and socio-demographics were obtained. Latent Class Analysis was used to determine unhealthy lifestyle behaviours. Logistic regression analysis predicted class membership. About 78% of children had three or more unhealthy lifestyle behaviours, while 0.2% presented no risk. Two classes were identified: Class 1-Sedentary, poorer diet quality; and Class 2-Insufficiently active, better diet quality, 35% and 65% of the population, respectively. More mature children (Odds Ratio (OR = 6.75; 95%CI = 4.74–10.41, and boys (OR = 3.06; 95% CI = 1.98–4.72 were more likely to be overweight/obese. However, those belonging to Class 2 were less likely to be overweight/obese (OR = 0.60; 95% CI = 0.43–0.84. Maternal education level and household income did not significantly predict weight status (p ≥ 0.05.

  20. Differences in the chemical profiles and biological activities of Paeonia lactiflora and Paeonia obovata.

    Bae, Ji-Yeong; Kim, Chul Young; Kim, Hyun Jin; Park, Jong Hee; Ahn, Mi-Jeong

    2015-02-01

    Paeonia lactiflora and P. obovata are perennial herbs, each root of which has been consumed as a major oriental medicine, Paeoniae Radix and a famous folk medicine, Mountain Paeony Root, respectively. Although morphological studies have been performed comparing these two plants, there is insufficient scientific evidence that characterizes the differences in their chemical profiles and biological activities. Hence, the present study was undertaken to compare these two medicinal foods using a high-performance liquid chromatography-diode-array detector (HPLC-DAD) analysis and a gastric ulcer model in mice. HPLC analysis employed to assess the nine components revealed that P. lactiflora exhibited higher contents of phenolic compounds than P. obovata. Although a monoterpene glycoside, 6'-O-acetylpaeoniflorin was identified in P. obovata, it was not detected in P. lactiflora. Multivariate statistical analysis for HPLC data revealed that the orthogonal projections to latent structure-discriminant analysis is more appropriate than principal component analysis for differentiating the two groups. Moreover, the 50% methanol P. lactiflora extract (PL) was more effective against experimental gastric ulcer than P. obovata extract (PO) in the HCl/ethanol-induced ulcer model. In addition, PL displayed higher 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and lower nitric oxide production in a murine macrophage cell line, RAW 264.7, than PO. The DPPH radical scavenging activity of PL was as high as that of the positive control, butylated hydroxytoluene, at a concentration of 25 μg/mL. PMID:25299493

  1. Lipid Profile and Serum Paraoxonase1 Activity in CRF Patients Pre and Posthemodialysis

    Nitin S. Nagane1* and Jayshree V. Ganu2

    2011-01-01

    Full Text Available Chronic renal failure (CRF is associated with an increased risk of cardiovascular disease (CVD. In the present study, 30 CRF patients undergoing hemodialysis and 50 healthy controls matching in age and sex were included. We have estimated blood urea, serum creatinine, lipid profile and serum Paraoxonase1 (PON1 activity in pre and post hemodialytic samples. HDL-Cholesterol (HDLC and serum Paraoxonase1(PON1 activity was found to be significantly reduced (P<0.001 in CRF patients as compared to that of controls. However HDL-Cholesterol (HDLC and Paraoxonase1 (PON1 show significant elevation (P<0.001 post hemodialysis than prehemodialytic samples of CRF patients. The levels of blood urea, serum creatinine, total cholesterol, LDL-Cholesterol (LDLC and Triglyceride (TG were significantly elevated (P<0.001 in CRF patients. After hemodialysis these parameters were significantly reduced (P<0.001 as compared to pre hemodialytic samples. The low HDL-Cholesterol (HDLC and serum Paraoxonase1 (PON1 activity may be responsible factor for cardiovascular disease associated with CRF. Therefore, management of CRF patients by Hemodialysis (HD has beneficial effect.

  2. Antioxidant activity and fatty acid profile of fermented milk prepared by Pediococcus pentosaceus.

    Balakrishnan, Gayathri; Agrawal, Renu

    2014-12-01

    Probiotics are the class of beneficial microorganisms that have positive influence on the health when ingested in adequate amounts. Probiotic fermented milk is one of the dairy products that is prepared by using probiotic lactic acid bacteria. The study comprised preparation of fermented milk from various sources such as cow, goat and camel. Pediococcus pentosaceus which is a native laboratory isolate from cheese was utilized for the product formation. Changes in functional properties in the fermented milks obtained from three different species were evaluated. Antioxidant activity determined by DPPH assay showed activity in probiotic fermented milk obtained from all the products being highest in goat milk (93 %) followed by product from camel milk (86 %) and then product from cow milk (79 %). The composition of beneficial fatty acids such as stearic acid, oleic acid and linoleic acid were higher in fermented milk than the unfermented ones. Results suggested that probiotic bacteria are able to utilize the nutrients in goat and camel milk more efficiently compared to cow milk. Increase in antioxidant activity and fatty acid profile of fermented milks enhances the therapeutic value of the products. PMID:25477694

  3. Characterization of inflammatory markers and transcriptome profiles of differentially activated embryonic stem cell-derived microglia.

    Beins, Eva; Ulas, Thomas; Ternes, Svenja; Neumann, Harald; Schultze, Joachim L; Zimmer, Andreas

    2016-06-01

    Microglia, the immune cells of the CNS, are highly adaptive cells that can acquire different pro- and anti-inflammatory activation states with distinct functions in CNS homeostasis and pathologies. To study microglial function in vitro, primary microglia or immortalized cell lines are commonly used. An alternative to these cells are embryonic stem cell-derived microglia (ESdM). ESdM have previously been shown to be very similar to primary microglia in terms of expression profiles and surface molecules. In this study, ESdM and primary microglia were treated with different inflammatory stimulants to analyze their ability to adopt different activation states. Using quantitative real-time PCR, comparative transcriptomics, ELISA, and flow cytometry, we found that different activation states can be induced in ESdM, which are similar to those found in primary microglia. These states are characterized by specific sets of inflammatory marker molecules and differential transcriptome signatures. Our results show that ESdM are a valuable alternative cell model to study microglial functions and neuroinflammatory mechanisms. GLIA 2016;64:1007-1020. PMID:26959607

  4. Flavonoid profile, antioxidant and cytotoxic activity of different extracts from Algerian Rhamnus alaternus L. bark

    Soulef Boussahel

    2015-01-01

    Full Text Available Background: Rhamnus alaternus (Rhamnaceae L. has been traditionally used for treatment of many diseases. Objective: In this study, we determined the antioxidant/free radical scavenger properties, the flavonoid profile and the cytotoxicity of aqueous and methanolic extracts obtained by maceration from Algerian R. alaternus bark, like also of aqueous extract prepared by decoction according to the traditional method. This to estimate the usefulness of the drug traditional preparation and compare it with those made in the laboratory. Materials and Methods: The antioxidant activity of the extracts was evaluated using five different redox-based assays, all involving one redox reaction with the oxidant. High-performance liquid chromatography/diode array detection/electrospray ionization mass spectrometry analysis was used to identify and quantify the fl avonoids content. Cytotoxicity on human monocytic leukemia cells (U937 was also carried out. Results: All the extracts tested showed a good antioxidant/free radical scavenger activity and a similar flavonoid fingerprint. However, the methanolic one presented the best antioxidant activity that can be due to the highest flavonoid amount and significantly reduced the proliferation of leukemia cells. The results confirm that the extract prepared by decoction contains efficient antioxidant compounds and this justifies in part the therapeutic and preventive usefulness. Moreover, the methanolic extract exerted excellent cytotoxicity on U937 that could be attributed to kaempferol and rhamnocitrin glycosides.

  5. Phenolic Profile and In vitro Antioxidant Activity of Endemic Bulgarian Carduus Species

    Dimitrova-Dyulgerova, Ivanka; Zhelev, Iliya; Mihaylova, Dasha

    2015-01-01

    Background: Plant species from genus Carduus are widely distributed in the world and represented in Bulgaria by 14 species. Previous investigations on this genus demonstrated a strong antioxidant potential of extract from some Bulgarian Carduus species. Objective: The present study investigates the phenolic profile and the antioxidant potential of different extracts obtained from four endemic Compositae herbs, growing wild in Bulgaria: Carduus armatus Boiss and Heldr., Carduus candicans Waldst. et Kit ssp. globifer (Velen.) Kazmi., Carduus rhodopaeus Velen. and Carduus thracicus (Velen.) Hayek. Materials and Methods: Antioxidant capacity of the obtained extracts was estimated with 2,2-diphenyl-1-picrylhydrazyl, 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid), and ferric reducing antioxidant power and copper reduction antioxidant assays. Phenolic profile was estimated by high performance liquid chromatography. Results: Eleven phenolic acids and eight flavonoids were quantified in the inflorescences. Sinapic (2760.72 ± 15.68 μg/g dry weight [dw]), chlorogenic (2564.50 ± 19.73 μg/g dw) and ferulic acids (1648.71 ± 19.57 μg/g dw), as well as luteolin (2345.45 ± 18.61 μg/g dw) and apigenin (1332.75 ± 12.05 μg/g dw) were found to be the predominant compounds. The above contents are the highest values found in C. candicans ssp. globifer. The highest established antioxidant activity (AOA) was in favor of the ethanolic extracts, and the extract of C. rhodopaeus affirmed with the highest AOA among the investigated plant species. Conclusion: All identified phenolic compounds were reported for the 1st time in the studied endemic Carduus species, as well as their antioxidant capacities. The present study revealed that these plant species could be used as sources of antioxidants with potential medicinal properties. SUMMARY Phenolic acids and flavonoid profiles of four endemic compositae herbs, growing wild in Bulgaria: Carduus armatus, Carduus candicans ssp

  6. Interaction Design: Where’s the Graphic Designer in the Graphical user Interface?

    Wood, Dave

    2009-01-01

    This paper will, from a visual communication perspective, explore the role over the last 40 years of the graphic designer within graphical user interface design. I am specifically interested in how graphic design has had to respond to designing for interactions in the new digital media. To do this I will also examine how interactive design has impacted upon graphic design and vice versa. In order to conclude on the present position I will explore the roots and formation of the graphic design ...

  7. Distinct BOLD activation profiles following central and peripheral oxytocin administration in awake rats

    Craig F Ferris

    2015-09-01

    Full Text Available A growing body of literature has suggested that intranasal oxytocin (OT or other systemic routes of administration can alter prosocial behavior, presumably by directly activating OT sensitive neural circuits in the brain. Yet there is no clear evidence that OT given peripherally can cross the blood-brain-barrier at levels sufficient to engage the OT receptor. To address this issue we examined changes in blood oxygen level dependent (BOLD signal intensity in response to peripheral OT injections (0.1, 0.5 or 2.5 mg/kg during functional magnetic resonance (fMRI in awake rats imaged at 7.0 tesla. These data were compared to OT (1ug/5 µl given directly to the brain via the lateral cerebroventricle. Using a 3D annotated MRI atlas of the rat brain segmented into 171 brain areas and computational analysis we reconstructed the distributed integrated neural circuits identified with BOLD fMRI following central and peripheral OT. Both routes of administration caused significant changes in BOLD signal within the first 10 min of administration. As expected, central OT activated a majority of brain areas known to express a high density of OT receptors e.g., lateral septum, subiculum, shell of the accumbens, bed nucleus of the stria terminalis. This profile of activation was not matched by peripheral OT. The change in BOLD signal to peripheral OT did not show any discernible dose-response. Interestingly, peripheral OT affected all subdivisions of the olfactory bulb, in addition to the cerebellum and several brainstem areas relevant to the autonomic nervous system, including the solitary tract nucleus. The results from this imaging study do not support a direct central action of peripheral OT on the brain. Instead, the patterns of brain activity suggest that peripheral OT may interact at the level of the olfactory bulb and through sensory afferents from the autonomic nervous system to influence brain activity.

  8. Active Tectonics of off-Hokuriku, Central Japan, by two ships seismic reflection profiling

    Kato, Naoko; Sato, Hiroshi; Ishiyama, Tatsuya; Abe, Susumu; Shiraishi, Kazuya

    2015-04-01

    Along the southern to eastern margin of the Sea of Japan, active faults are densely distributed. These submarine active faults produced tsunami disasters, such as 1983 Nihonkai-chubu earthquake (M7.7) and 1993 Hokkaido Nansei-oki earthquake (M7.8). To estimate tsunami hazards, we performed deep seismic reflection profiling to obtain the information of tsunami source faults, off-Hokuriku area in the central part of Honshu, Japan. The survey is carried out as a part of research project named "the integrated research project on seismic and tsunami hazards around the Sea of Japan" funded by MEXT. To obtain long offset data in busy marine activity area, we used two vessels; a gun-ship with 3020 cu. inch air-gun and a cable-ship with a 2-km-long, streamer cable with 156 channels and 480 cu. inch air-gun. Common-midpoint reflection data were acquired using two ships at 4 km offset. The survey area consists of stretched continental crust associated with rifting and opening of the Sea of Japan in early Miocene and is marked by densely distributed syn-rift normal faults. Fault reactivation of normal faults as reverse faults is common. Two phases of fault reactivation are identified from the seismic sections after termination of opening of the Sea of Japan. One is the late Miocene NS trending shortening deformation. This is produced by NS-trending convergence of the Shikoku basin (15 Ma), which belongs to the Philippine Sea plate (PHS) to SW Japan at Nankai trough (Kimura et al., 2005). After the initiation of the subduction of PHS at Nankai trough, the strong shortening deformation is terminated and the fold-and-thrust belt was unconformably covered by sub-horizontal Pliocene sediments. Some horizons of unconformities represent multiple events of shortening driven from the subduction interface. Some normal faults reactivated as active strike-slip and reverse faults in Quaternary. Well observed example is the 2007 Noto peninsula earthquake (M6.8). The 2007 Noto peninsula

  9. Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory.

    Haberman, Rebecca P; Colantuoni, Carlo; Koh, Ming Teng; Gallagher, Michela

    2013-01-01

    Aging is often associated with cognitive decline, but many elderly individuals maintain a high level of function throughout life. Here we studied outbred rats, which also exhibit individual differences across a spectrum of outcomes that includes both preserved and impaired spatial memory. Previous work in this model identified the CA3 subfield of the hippocampus as a region critically affected by age and integral to differing cognitive outcomes. Earlier microarray profiling revealed distinct gene expression profiles in the CA3 region, under basal conditions, for aged rats with intact memory and those with impairment. Because prominent age-related deficits within the CA3 occur during neural encoding of new information, here we used microarray analysis to gain a broad perspective of the aged CA3 transcriptome under activated conditions. Behaviorally-induced CA3 expression profiles differentiated aged rats with intact memory from those with impaired memory. In the activated profile, we observed substantial numbers of genes (greater than 1000) exhibiting increased expression in aged unimpaired rats relative to aged impaired, including many involved in synaptic plasticity and memory mechanisms. This unimpaired aged profile also overlapped significantly with a learning induced gene profile previously acquired in young adults. Alongside the increased transcripts common to both young learning and aged rats with preserved memory, many transcripts behaviorally-activated in the current study had previously been identified as repressed in the aged unimpaired phenotype in basal expression. A further distinct feature of the activated profile of aged rats with intact memory is the increased expression of an ensemble of genes involved in inhibitory synapse function, which could control the phenotype of neural hyperexcitability found in the CA3 region of aged impaired rats. These data support the conclusion that aged subjects with preserved memory recruit adaptive mechanisms to

  10. Graphical programming at Sandia National Laboratories

    Sandia has developed an advanced operational control system approach, called Graphical Programming, to design, program, and operate robotic systems. The Graphical Programming approach produces robot systems that are faster to develop and use, safer in operation, and cheaper overall than altemative teleoperation or autonomous robot control systems. Graphical Programming also provides an efficient and easy-to-use interface to traditional robot systems for use in setup and programming tasks. This paper provides an overview of the Graphical Programming approach and lists key features of Graphical Programming systems. Graphical Programming uses 3-D visualization and simulation software with intuitive operator interfaces for the programming and control of complex robotic systems. Graphical Programming Supervisor software modules allow an operator to command and simulate complex tasks in a graphic preview mode and, when acceptable, command the actual robots and monitor their motions with the graphic system. Graphical Programming Supervisors maintain registration with the real world and allow the robot to perform tasks that cannot be accurately represented with models alone by using a combination of model and sensor-based control

  11. Phytochemical profiles and antioxidant activities in six species of ramie leaves.

    Yongsheng Chen

    Full Text Available Increased consumption of vegetables or plant food has been associated with decreased risk of developing major chronic diseases, such as cancers, diabetes, cardiovascular diseases, and age-related functional decline. Ramie leaves are rich in phenolics and flavonoids, which have been suggested for human health benefits. Phenolic contents, flavonoid contents, phenolic compounds, and anti-cancer properties in six species of ramie leaves were analyzed by Folin-reagent method, sodium borohydride/chloranil-based assay (SBC, HPLC method and antiproliferation, cytoxicity, respectively. Antioxidant activities were measured through peroxyl radical scavenging capacity (PSC method, oxygen radical absorbance capacity (ORAC method, and cellular antioxidant activity (CAA. Research indicated that Boehmeria penduliflora contained the highest total phenolic content (2313.7±27.28 mg GAE/100 g FW, and flavonoid content (1682.4±27.70 mg CAE/100 g FW. Boehmeria tricuspis showed the highest PSC value (9574.8±117.63 µM vit. C equiv./100 g FW, while Boehmeria penduliflora indicated the highest ORAC value (330.44±16.88 µmol Trolox equiv./g FW. The antioxidant activities were correlated with phenolic contents and flavonoid contents. Boehmeria tricuspis had the highest antiproliferative capacity with the lowest EC₅₀ (4.11±0.19 mg/mL. The results for the analyzed ramie for CAA were significantly different from each other (p<0.05, Boehmeria tricuspis had the highest CAA value (133.63±7.10 µmol QE/100 g. Benzoic acid, 4-coumaric acid, caffeic acid, and ferulic acid were the dominant phenolic ingredients in the ramie leaves according to HPLC analysis. Our research is the first report to study the phytochemical profiles and antioxidant activities in different species of ramie leaves for their health benefit.

  12. Polyphenolic Profile, Antioxidant and Anti-Inflammatory Activity of Eastern Teaberry (Gaultheria procumbens L.) Leaf Extracts.

    Michel, Piotr; Dobrowolska, Anna; Kicel, Agnieszka; Owczarek, Aleksandra; Bazylko, Agnieszka; Granica, Sebastian; Piwowarski, Jakub P; Olszewska, Monika A

    2014-01-01

    Dry leaf extracts of eastern teaberry (Gaultheria procumbens L.) were evaluated as a source of bioactive phytocompounds through systematic activity testing and phytochemical profiling. The antioxidant efficiency was tested using five complementary in vitro models (DPPH; FRAP; linoleic acid (LA) peroxidation assay; O2•- and H2O2 scavenging tests) in parallel with standard antioxidants. The 75% methanol extract and its diethyl ether, ethyl acetate (EAF), n-butanol and water fractions exhibited the dose-dependent responses in all assays, with the highest capacities found for EAF (DPPH EC50 = 2.9 μg/mL; FRAP = 12.8 mmol Fe2+/g; IC50 for LA-peroxidation = 123.9 μg/mL; O2•- SC50 = 3.9 μg/mL; H2O2 SC50 = 7.2 μg/mL). The EAF had also the highest anti-inflammatory activity in the inhibition tests of lipoxygenase and hyaluronidase (60.14% and 21.83% effects, respectively, at the concentration of 100 μg/mL). Activity parameters of the extracts correlated strongly with the levels of total phenolics (72.4-270.7 mg GAE/g), procyanidins, and phenolic acids, whereas for flavonoids only moderate effects were observed. Comprehensive UHPLC-PDA-ESI-MS3 and HPLC-PDA studies led to the identification of 35 polyphenols with a procyanidin A-type trimer, quercetin 3-O-glucuronide, isomers of caffeoylquinic acids, and (‒)-epicatechin being the dominant components. Significant activity levels, high phenolic contents and high extraction yields (39.4%-42.5% DW for defatted and crude methanol extracts, respectively) indicate the value of eastern teaberry leaves as bioactive products. PMID:25493634

  13. Activity-based protein profiling of ammonia monooxygenase in Nitrosomonas europaea.

    Bennett, Kristen; Sadler, Natalie C.; Wright, Aaron T.; Yeager, Chris; Hyman, Michael R.

    2016-01-29

    Nitrosomonas europaea is an aerobic nitrifying bacterium that oxidizes ammonia (NH3) to nitrite (NO2-) through the sequential activities of ammonia monooxygenase (AMO) and hydroxylamine oxidoreductase (HAO). Many alkynes are mechanism-based inactivators of AMO and here we describe an activity-based protein profiling method for this enzyme using 1,7-octadiyne (17OD) as a probe. Inactivation of NH4+-dependent O2 uptake by N. europaea by 17OD was time- and concentration-dependent. The effects of 17OD were specific for ammonia-oxidizing activity and de novo protein synthesis was required to reestablish this activity after cells were exposed to 17OD. Cells were reacted with AlexaFluor 647-azide using a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, solubilized and analyzed by SDS-PAGE and IR scanning. A fluorescent 28 kDa polypeptide was observed for cells previously exposed to 17OD, but not for cells treated with either allylthiourea or acetylene prior to exposure to 17OD, or for cells not previously exposed to 17OD. The 28 kDa polypeptide was membrane-associated and aggregated when heated with β-mercaptoethanol and SDS. The fluorescent 28 kDa polypeptide was also detected in cells pretreated with other diynes, but not in cells pretreated with structural homologs containing a single ethynyl functional group. The membrane fraction from 17OD-treated cells was conjugated with biotin-azide and solubilized in SDS. Streptavidin affinity-purified polypeptides were on-bead trypsin-digested and amino acid sequences of the peptide fragments were determined by LC-MS analysis. Peptide fragments from amoA were the predominant peptides detected in 17OD-treated samples. In gel digestion and MALDI-TOF/TOF analysis also confirmed the fluorescent 28 kDa polypeptide was amoA.

  14. Phytochemical profiles and antioxidant activities in six species of ramie leaves.

    Chen, Yongsheng; Wang, Gaoyan; Wang, Hong; Cheng, Chaohua; Zang, Gonggu; Guo, Xinbo; Liu, Rui Hai

    2014-01-01

    Increased consumption of vegetables or plant food has been associated with decreased risk of developing major chronic diseases, such as cancers, diabetes, cardiovascular diseases, and age-related functional decline. Ramie leaves are rich in phenolics and flavonoids, which have been suggested for human health benefits. Phenolic contents, flavonoid contents, phenolic compounds, and anti-cancer properties in six species of ramie leaves were analyzed by Folin-reagent method, sodium borohydride/chloranil-based assay (SBC), HPLC method and antiproliferation, cytoxicity, respectively. Antioxidant activities were measured through peroxyl radical scavenging capacity (PSC) method, oxygen radical absorbance capacity (ORAC) method, and cellular antioxidant activity (CAA). Research indicated that Boehmeria penduliflora contained the highest total phenolic content (2313.7±27.28 mg GAE/100 g FW), and flavonoid content (1682.4±27.70 mg CAE/100 g FW). Boehmeria tricuspis showed the highest PSC value (9574.8±117.63 µM vit. C equiv./100 g FW), while Boehmeria penduliflora indicated the highest ORAC value (330.44±16.88 µmol Trolox equiv./g FW). The antioxidant activities were correlated with phenolic contents and flavonoid contents. Boehmeria tricuspis had the highest antiproliferative capacity with the lowest EC₅₀ (4.11±0.19 mg/mL). The results for the analyzed ramie for CAA were significantly different from each other (pphenolic ingredients in the ramie leaves according to HPLC analysis. Our research is the first report to study the phytochemical profiles and antioxidant activities in different species of ramie leaves for their health benefit. PMID:25243741

  15. Activity-Based Protein Profiling of Ammonia Monooxygenase in Nitrosomonas europaea.

    Bennett, Kristen; Sadler, Natalie C; Wright, Aaron T; Yeager, Chris; Hyman, Michael R

    2016-04-01

    Nitrosomonas europaea is an aerobic nitrifying bacterium that oxidizes ammonia (NH3) to nitrite (NO2 (-)) through the sequential activities of ammonia monooxygenase (AMO) and hydroxylamine dehydrogenase (HAO). Many alkynes are mechanism-based inactivators of AMO, and here we describe an activity-based protein profiling method for this enzyme using 1,7-octadiyne (17OD) as a probe. Inactivation of NH4 (+)-dependent O2 uptake by N. europaea by 17OD was time- and concentration-dependent. The effects of 17OD were specific for ammonia-oxidizing activity, andde novoprotein synthesis was required to reestablish this activity after cells were exposed to 17OD. Cells were reacted with Alexa Fluor 647 azide using a copper-catalyzed azide-alkyne cycloaddition (CuAAC) (click) reaction, solubilized, and analyzed by SDS-PAGE and infrared (IR) scanning. A fluorescent 28-kDa polypeptide was observed for cells previously exposed to 17OD but not for cells treated with either allylthiourea or acetylene prior to exposure to 17OD or for cells not previously exposed to 17OD. The fluorescent polypeptide was membrane associated and aggregated when heated with β-mercaptoethanol and SDS. The fluorescent polypeptide was also detected in cells pretreated with other diynes, but not in cells pretreated with structural homologs containing a single ethynyl functional group. The membrane fraction from 17OD-treated cells was conjugated with biotin-azide and solubilized in SDS. Streptavidin affinity-purified polypeptides were on-bead trypsin-digested, and amino acid sequences of the peptide fragments were determined by liquid chromatography-mass spectrometry (LC-MS) analysis. Peptide fragments from AmoA were the predominant peptides detected in 17OD-treated samples. In-gel digestion and matrix-assisted laser desorption ionization-tandem time of flight (MALDI-TOF/TOF) analyses also confirmed that the fluorescent 28-kDa polypeptide was AmoA. PMID:26826234

  16. Polyphenolic Profile, Antioxidant and Anti-Inflammatory Activity of Eastern Teaberry (Gaultheria procumbens L. Leaf Extracts

    Piotr Michel

    2014-12-01

    Full Text Available Dry leaf extracts of eastern teaberry (Gaultheria procumbens L. were evaluated as a source of bioactive phytocompounds through systematic activity testing and phytochemical profiling. The antioxidant efficiency was tested using five complementary in vitro models (DPPH; FRAP; linoleic acid (LA peroxidation assay; O2•− and H2O2 scavenging tests in parallel with standard antioxidants. The 75% methanol extract and its diethyl ether, ethyl acetate (EAF, n-butanol and water fractions exhibited the dose-dependent responses in all assays, with the highest capacities found for EAF (DPPH EC50 = 2.9 μg/mL; FRAP = 12.8 mmol Fe2+/g; IC50 for LA-peroxidation = 123.9 μg/mL; O2•− SC50 = 3.9 μg/mL; H2O2 SC50 = 7.2 μg/mL. The EAF had also the highest anti-inflammatory activity in the inhibition tests of lipoxygenase and hyaluronidase (60.14% and 21.83% effects, respectively, at the concentration of 100 μg/mL. Activity parameters of the extracts correlated strongly with the levels of total phenolics (72.4–270.7 mg GAE/g, procyanidins, and phenolic acids, whereas for flavonoids only moderate effects were observed. Comprehensive UHPLC-PDA-ESI-MS3 and HPLC-PDA studies led to the identification of 35 polyphenols with a procyanidin A-type trimer, quercetin 3-O-glucuronide, isomers of caffeoylquinic acids, and (‒-epicatechin being the dominant components. Significant activity levels, high phenolic contents and high extraction yields (39.4%–42.5% DW for defatted and crude methanol extracts, respectively indicate the value of eastern teaberry leaves as bioactive products.

  17. Chromatogram Profiles and Cytotoxic Activity of Irradiated Mahkota Dewa (Phaleria Macrocarpa Scheff. Boerl Leaves

    E. Katrin1

    2011-04-01

    Full Text Available Gamma irradiation has been used by the industries for preservation of herbal medicine, but it has not been studied the effect of gamma irradiation on their efficacy, especially their bioactivity as anticancer substances. The purpose of this research was to study the effect of gamma irradiation on the mahkota dewa leaves which has been claimed to contain potent anticancer substances. Maceration of dried mahkota dewa leaves successively with n-hexane, ethyl acetate, and ethanol gave crude extracts which the ethyl acetate was the most cytotoxic extract against leukemia L1210 cells with an inhibition concentration fifty (IC50 value of 10.3 µg/ml. Further separation of ethyl acetate extract by column chromatograph gave 7 fractions, and fraction 2 showed the most cytotoxic fraction exhibited the most cytotoxic extract against leukemia L1210 cells with an IC50 value of 1.9 µg/ml. Since, the fraction 2 of ethyl acetate extract was the most potent fraction, the irradiated samples were treated with the same procedure as treatment of fraction 2 from control sample. Cytotoxic activity test of fractions 2 from irradiated samples showed that the cytotoxic activity decreased depending on increasing of irradiation dose. Gamma irradiation dose up to 7.5 kGy on mahkota dewa leaves could decreased the cytotoxic activity of fraction 2 as the most cytotoxic-potential fraction against leukemia L1210 cells, but decreasing the cytotoxic activity has not exceeded the limit of the fraction declared inactive. So that the irradiation dose up to 7.5 kGy can be used for decontamination of bacteria and fungus/yeast without eliminating the cytotoxic activity. Gamma irradiation also caused changes in the thin layer chromatograph (TLC spots and HPLC chromatograms profiles of fraction 2 which was the most cytotoxic fraction in ethyl acetate extract of mahkota dewa leaves against leukemia L1210 cells. One of the main peaks (peak 1 on HPLC chromatograms decreased with increasing

  18. Activity profiles of 309 ToxCastTM chemicals evaluated across 292 biochemical targets

    Understanding the potential health risks posed by environmental chemicals is a significant challenge elevated by the large number of diverse chemicals with generally uncharacterized exposures, mechanisms, and toxicities. The present study is a performance evaluation and critical analysis of assay results for an array of 292 high-throughput cell-free assays aimed at preliminary toxicity evaluation of 320 environmental chemicals in EPA's ToxCastTM project (Phase I). The chemicals (309 unique, 11 replicates) were mainly precursors or the active agent of commercial pesticides, for which a wealth of in vivo toxicity data is available. Biochemical HTS (high-throughput screening) profiled cell and tissue extracts using semi-automated biochemical and pharmacological methodologies to evaluate a subset of G-protein coupled receptors (GPCRs), CYP450 enzymes (CYPs), kinases, phosphatases, proteases, HDACs, nuclear receptors, ion channels, and transporters. The primary screen tested all chemicals at a relatively high concentration 25 μM concentration (or 10 μM for CYP assays), and a secondary screen re-tested 9132 chemical-assay pairs in 8-point concentration series from 0.023 to 50 μM (or 0.009-20 μM for CYPs). Mapping relationships across 93,440 chemical-assay pairs based on half-maximal activity concentration (AC50) revealed both known and novel targets in signaling and metabolic pathways. The primary dataset, summary data and details on quality control checks are available for download at (http://www.epa.gov/ncct/toxcast/).

  19. A prospective study of injury and activity profile in elite soccer referees and assistant referees.

    Wilson, F

    2011-10-01

    Injuries to soccer players have been extensively examined, but not the injury experience of referees and assistant referees. This study aimed to determine the injury incidence and activity profile of soccer match officials. A 12 month prospective cohort study was used to collect activity and injury data of 31 participants who reported their training and match exposure and their injury incidence by means of weekly online questionnaire. Study participants spent a mean of 2632 hrs training and 1704 hrs officiating over the 12 month study period. Thirty eight injuries were recorded, (8.8 injuries\\/1000 hr of training (CI 6.2 to 12.0) and 16.4 injuries\\/1000 hr for match officiating (CI 10.9 to 23.8)), (Risk Ratio 4.3, 2.1 to 8.9). Fifty five percent (CI 40 to 70%) of the injuries were to muscles, and 76% (CI 61 to 87%) were to the lower leg. Overuse injuries represented 61% (CI 45 to 74%) of all cases. Findings showed that the injury frequency rate associated with soccer referees is higher than that in a number of other non contact sports. The injury incidence associated with training for soccer referees is higher than that associated with training for soccer players. Further prospective studies are merited to examine effectiveness and availability of injury management programmes to establish the welfare of this population.

  20. Secondary Metabolite Profile, Antioxidant Capacity, and Mosquito Repellent Activity of Bixa orellana from Brazilian Amazon Region

    Annamaria Giorgi

    2013-01-01

    Full Text Available The Brazilian flora was widely used as source of food and natural remedies to treat various diseases. Bixa orellana L. (Bixaceae, also known as annatto, urucù, or achiote, is a symbol for the Amazonian tribes that traditionally use its seeds as coloured ink to paint their bodies for religious ceremonies. The aim of this study was to investigate the volatile organic compounds (VOCs profile of B. orellana fresh fruits (in vivo sampled, dried seeds, wood, bark, and leaves analyzed with Headspace solid-phase microextraction coupled with gas chromatography and mass spectrometry. A screening on phenolic content (the Folin-Ciocalteu assay and antiradical activity (DPPH assay of seeds was also conducted. In addition, the repellent properties of seed extracts against Aedes aegypti L. were investigated. Volatile compounds detected in B. orellana samples consisted mainly of sesquiterpenes, monoterpenes, and arenes: α-humulene is the major volatile compound present in seed extracts followed by D-germacrene, γ-elemene, and caryophyllene. B. orellana proved to be a good source of antioxidants. Preliminary data on repellency against A. aegypti of three different dried seed extracts (hexane, ethanol, and ethanol/water indicated a significant skin protection activity. A protection of 90% and 73% for hexane and ethanol/water extracts was recorded.

  1. Site-directed mutation of a laccase from Thermus thermophilus: Effect on the activity profile

    Liu Xin

    2012-01-01

    Full Text Available A site-directed mutant R453T of a laccase from Thermus thermophilus HB27 (Tth-laccase was constructed in order to investigate the effect on laccase catalytic properties. The mutated gene was cloned and overexpressed in Escherichia coli. Nickel-affinity purification was achieved and followed by copper ion incorporation. The mature mutated enzyme was quantitatively equal to the wild type. A photometric assay based on the oxidation of the substrate 2,2-azino-bis-(3- ethylbenzthiazoline-6-sulfonate (ABTS was employed in comparison with the wild-type Tth-laccase on catalytic properties. The R453T mutant exhibited improvement in substrate affinity and specific activity at room temperature, whereas those parameters were not significantly influenced when the temperature increased up to 65°C or higher. The mutant had better catalytic activity than that of the wild type at acidic pH. Investigated by circular dichroism spectroscopy, the mutant Tth-laccase displayed similar profiles at low and high temperatures.

  2. Distribution of active organic matter in the soil profiles of natural and agricultural ecosystems

    Khodzhaeva, A. K.; Semenov, V. M.

    2015-12-01

    The amount of active (potentially mineralizable) organic carbon (C0) in the 1-m-deep layer of typical chernozem, dark-gray forest soil, and gray forest soil was estimated for virgin plots and arable land. It was shown that C0 is mainly found in the topsoil (0-20 cm), where its pool reaches 32-60% of the total amount of C0 in the layer of 0-100 cm. The C0 content and its portion in the total organic carbon decrease down the soil profiles. The disturbance of the structure of the pool of active organic carbon—the loss of the moderately mineralizable (0.1 > k 2 > 0.1 day-1) fraction—takes place in the upper horizon of plowed soils. The total pool of C0 in the upper meter of typical chernozem under cropland and under meadow-steppe cenosis comprises 2.8 and 5.2 t/ha, respectively; for the dark gray forest soil under cropland and forest, it reaches 5.5 and 9.8 t/ha, respectively; and for the gray forest soil under cropland and forest, 2.4 and 3.4 t/ha, respectively. The pools of C0 in the typical chernozem. dark gray forest, and gray forest soils are comparable with the values of the annual C-CO2 emission from the soils of these zones.

  3. Assessing the agonist profiles of the prostacyclin analogues treprostinil and naxaprostene, particularly their DP₁ activity.

    Syed, Nawazish-i-Husain; Jones, Robert L

    2015-04-01

    In this study, the inhibitory profiles of the prostacyclin analogues treprostinil and naxaprostene on several isolated smooth muscle preparations have been investigated. Treprostinil was an agonist for prostanoid DP1, EP2 and IP receptors, but not EP4 receptors; its DP1 potency was only 3-4 times less than PGD2 itself. Naxaprostene was much more selective for IP receptors and tended towards partial agonism. Treprostinil is a 13,14-dihydro analogue and the role of conformation around C12-15 in controlling agonist specificity is debated; the synthesis of new analogues is proposed and possible clinical usage discussed. In terms of selective prostanoid antagonists employed, BW-A868C/MK-0524 (DP1), ACA-23 (EP2) and GW-627368 (EP4) were found fit for purpose. However, the IP antagonist RO-1138452 was compromised by α1 and α2-adrenoceptor-mediated contractile activity on rat tail artery and anti-muscarinic activity on mouse trachea. There is a need for IP receptor antagonists with better selectivity and higher affinity. PMID:25542069

  4. Enhancing the T-shaped learning profile when teaching hydrology using data, modeling, and visualization activities

    Sanchez, Christopher A.; Ruddell, Benjamin L.; Schiesser, Roy; Merwade, Venkatesh

    2016-03-01

    Previous research has suggested that the use of more authentic learning activities can produce more robust and durable knowledge gains. This is consistent with calls within civil engineering education, specifically hydrology, that suggest that curricula should more often include professional perspective and data analysis skills to better develop the "T-shaped" knowledge profile of a professional hydrologist (i.e., professional breadth combined with technical depth). It was expected that the inclusion of a data-driven simulation lab exercise that was contextualized within a real-world situation and more consistent with the job duties of a professional in the field, would provide enhanced learning and appreciation of job duties beyond more conventional paper-and-pencil exercises in a lower-division undergraduate course. Results indicate that while students learned in both conditions, learning was enhanced for the data-driven simulation group in nearly every content area. This pattern of results suggests that the use of data-driven modeling and visualization activities can have a significant positive impact on instruction. This increase in learning likely facilitates the development of student perspective and conceptual mastery, enabling students to make better choices about their studies, while also better preparing them for work as a professional in the field.

  5. HPLC-TOF/MS profile and nitric oxide scavenging activity of Orthosiphon stamineus leaf extracts

    Gabriel Akyirem Akowuah; Zhari Ismail; Maraiam Ahmad

    2012-01-01

    Objective: The aim of the present study is to develop liquid chromatography (LC)/Time-of-flight mass spectrometry (TOF/MS) profile for methanol and water extracts of Orthosiphon stamineus leaf using SEN and RA as flavonoid and non-flavonoid polyphenolic markers in the extracts. The study also evaluates in vitro nitric oxide radical scavenging effect of the extracts. Method:Orthogonal Time of Flight Mass Spectrometer equipped with HPLC separation module was used in the analyses of the extract. The in vitro nitric oxide scavenging activity of the extracts was measured according to the method described by Rao. Results: The qualitative analysis of the extracts performed with HPLC-TOF/MS confirmed the presence sinensitin (SEN) and rosmarinic acid (RA) in the extracts. The extracts showed in vitro nitric oxide scavenging activities. Conclusions: The HPLC-TOF/MS method could be employed for quality determination of herbal medicinal products and formulations containing O. stamineus. The extracts may play a significant role in prevention of degenerate disease due to its ability to scavenge nitric oxide radical.

  6. Phenolic Profiles and Contribution of Individual Compounds to Antioxidant Activity of Apple Powders.

    Raudone, Lina; Raudonis, Raimondas; Liaudanskas, Mindaugas; Viskelis, Jonas; Pukalskas, Audrius; Janulis, Valdimaras

    2016-05-01

    Apples (Malus domestica L.) are the most common source of phenolic compounds in northern European diet. Besides pectins, dietary fibers, vitamins, and oligosaccharides they contain phenolic compounds of different classes. Apple powders are convenient functional forms retaining significant amounts of phenolic antioxidants. In this study reducing and radical scavenging profiles of freeze-dried powders of "Aldas,ˮ "Auksis,ˮ "Connel Red,ˮ "Ligol,ˮ "Lodel,ˮ and "Rajkaˮ were determined and phenolic constituents were identified using ultra high-performance liquid chromatography coupled to quadrupole and time-of-flight mass spectrometers. A negative ionization mode was applied and seventeen compounds: phenolic acids (coumaroylquinic, chlorogenic), flavonoids (quercetin derivatives), and procyanidin derivatives (B1, B2, and C1) were identified in all tested apple samples. Total values of Trolox equivalents varied from 7.72 ± 0.32 up to 20.02 ± 0.52 and from 11.10 ± 0.57 up to 21.42 ± 0.75 μmol/g of dry weight of apple powder in FRAP (ferric reducing antioxidant power) and ABTS (2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) postcolumn assays, respectively. The greatest Trolox equivalent values were determined for apples of "Aldasˮ cultivar. Chlorogenic acid and procyanidin C1 were the most significant contributors to total reducing and radical scavenging activity in all apple cultivars tested, therefore they could be considered as markers of antioxidant activity. PMID:27002313

  7. Insights on the Phytochemical Profile (Cyclopeptides and Biological Activities of Calotropis procera Latex Organic Fractions

    Thiago Lustosa Jucá

    2013-01-01

    Full Text Available Calotropis procera is a medicinal plant whose pharmacological properties are associated with its latex. Here, the Calotropis procera latex fractions were investigated in an attempt to trace its phytochemical profile and measure its anti-inflammatory and toxicity activity. The crude latex was partitioned, yielding five fractions (49.4% hexane, 5.2% dichloromethane, 2.0% ethyl acetate, 2.1% n-butanol, and 41.1% aqueous. Phytochemical screening and spectroscopy analysis revealed that dichloromethane is the most chemically diverse fraction. Triterpenes were detected in both the hexane and dichloromethane fractions, while flavonoids were detected in the dichloromethane and ethyl acetate fractions. These fractions were cytotoxic to cancer cell lines (LD50 0.05 to 3.9 μg/mL and lethal to brine shrimp (LD50 10.9 to 65.7 μg/mL. Reduced neutrophil migration in rats was observed in carrageenan-induced peritonitis for the dichloromethane (67%, ethyl acetate (56%, and aqueous (72% fractions. A positive reaction with tolidine and ninhydrin suggested that cyclopeptides are in the ethyl acetate fraction. It is therefore concluded that Calotropis procera latex dichloromethane and ethyl acetate fractions exhibit both in vitro and in vivo activities as well as anti-inflammatory properties. Cyclopeptide detection is especially interesting because previous attempts to investigate these low-molecular cyclic amino acid sequences in C. procera have failed.

  8. Isotope microscopy visualization of the adsorption profile of 2-methylisoborneol and geosmin in powdered activated carbon.

    Matsui, Yoshihiko; Sakamoto, Asuka; Nakao, Soichi; Taniguchi, Takuma; Matsushita, Taku; Shirasaki, Nobutaka; Sakamoto, Naoya; Yurimoto, Hisayoshi

    2014-09-16

    Decreasing the particle size of powdered activated carbon may enhance its equilibrium adsorption capacity for small molecules and micropollutants, such as 2-methylisoborneol (MIB) and geosmin, as well as for macromolecules and natural organic matter. Shell adsorption, in which adsorbates do not completely penetrate the adsorbent but instead preferentially adsorb near the outer surface of the adsorbent, may explain this enhancement in equilibrium adsorption capacity. Here, we used isotope microscopy and deuterium-doped MIB and geosmin to directly visualize the solid-phase adsorbate concentration profiles of MIB and geosmin in carbon particles. The deuterium/hydrogen ratio, which we used as an index of the solid-phase concentration of MIB and geosmin, was higher in the shell region than in the inner region of carbon particles. Solid-phase concentrations of MIB and geosmin obtained from the deuterium/hydrogen ratio roughly agreed with those predicted by shell adsorption model analyses of isotherm data. The direct visualization of the localization of micropollutant adsorbates in activated carbon particles provided direct evidence of shell adsorption. PMID:25162630

  9. Active flow control for reduction of fluctuating aerodynamic forces of a blunt trailing edge profiled body

    Naghib-Lahouti, Arash, E-mail: anaghibl@uwo.c [Boundary Layer Wind Tunnel Laboratory, University of Western Ontario, London, Ontario, N6A 5B9 (Canada); Hangan, Horia [Boundary Layer Wind Tunnel Laboratory, University of Western Ontario, London, Ontario, N6A 5B9 (Canada)

    2010-12-15

    Vortex shedding in the wake of two-dimensional bluff bodies is usually accompanied by three dimensional instabilities. These instabilities result in streamwise and vertical vorticity components which occur at a certain spanwise wavelength. The spanwise wavelength of the instabilities ({lambda}{sub Z}) depends on several parameters, including profile geometry and Reynolds number. The objective of the present work is to study the three dimensional wake instabilities for a blunt trailing edge profiled body, comprised of an elliptical leading edge and a rectangular trailing edge, and to manipulate these instabilities to control the aerodynamic forces. Results of numerical simulations of flow around the body at Re(d) = 400, 600, and 1000, as well as planar Laser Induced Fluorescence (LIF) flow visualizations at Re(d) = 600 and 1000 are analyzed to determine the wake vorticity structure and {lambda}{sub Z}. Based on the findings of these analyses, an active flow control mechanism for attenuation of the fluctuating aerodynamic forces on the body is proposed. The flow control mechanism is comprised of a series of trailing edge injection ports distributed across the span, with a spacing equal to {lambda}{sub Z}. Injection of a secondary flow leads to amplification of the three dimensional instabilities and disorganization of the von Karman vortex street. Numerical simulations indicate that the flow control mechanism can attenuate the fluctuating aerodynamic forces at lower Reynolds numbers (Re(d) = 400 and 600) where {lambda}{sub Z} is constant in time. However, the control mechanism loses its effectiveness at Re(d) = 1000, due to the temporal variations of {lambda}{sub Z}.

  10. Engineering graphic modelling a workbook for design engineers

    Tjalve, E; Frackmann Schmidt, F

    2013-01-01

    Engineering Graphic Modelling: A Practical Guide to Drawing and Design covers how engineering drawing relates to the design activity. The book describes modeled properties, such as the function, structure, form, material, dimension, and surface, as well as the coordinates, symbols, and types of projection of the drawing code. The text provides drawing techniques, such as freehand sketching, bold freehand drawing, drawing with a straightedge, a draughting machine or a plotter, and use of templates, and then describes the types of drawing. Graphic designers, design engineers, mechanical engine

  11. Inner-City Children's Graphics Call for Social Justice

    Lu, Lucia Y.

    2010-01-01

    In a graduate literacy course, the author as the teacher educator conceptualized "Visual Literacy" into the course. In-service and pre-service teachers from inner-city schools in Georgia and Virginia invited struggling writers to create graphic novels by envisioning life activities, using drawings, and invented spellings as well as…

  12. Helping Students Test Programs That Have Graphical User Interfaces

    Matthew Thornton

    2008-08-01

    Full Text Available Within computer science education, many educators are incorporating software testing activities into regular programming assignments. Tools like JUnit and its relatives make software testing tasks much easier, bringing them into the realm of even introductory students. At the same time, many introductory programming courses are now including graphical interfaces as part of student assignments to improve student interest and engagement. Unfortunately, writing software tests for programs that have significant graphical user interfaces is beyond the skills of typical students (and many educators. This paper presents initial work at combining educationally oriented and open-source tools to create an infrastructure for writing tests for Java programs that have graphical user interfaces. Critically, these tools are intended to be appropriate for introductory (CS1/CS2 student use, and to dovetail with current teaching approaches that incorporate software testing in programming assignments. We also include in our findings our proposed approach to evaluating our techniques.

  13. The research of graphics interface in nuclear plant isolation system

    The works of isolation, facility installation and testing are important operation activities between systems, structures, or components in nuclear plant. It focuses on operating facilities and preparing environment for facilities and provides the work around with credibility, felicitousness and security. The research is aiming at graphics interface in computer aided clearance system for the demands of nuclear plants. It integrates the facility virtual environment, run-time status and workflows by graphics interface. With the technology, it helps reduce maintenance periods, optimize the amount of blocked facilities, ensure the safety of work around, improve the facility reliability, and economize resource. The graphics interface technology is the first time implementation to operation system and helps improve nuclear plants operation efficiency. (authors)

  14. Potent Antidiabetic Activity and Metabolite Profiling of Melicope Lunu-ankenda Leaves.

    Al-Zuaidy, Mizher Hezam; Hamid, Azizah Abdul; Ismail, Amin; Mohamed, Suhaila; Abdul Razis, Ahmad Faizal; Mumtaz, Muhammad Waseem; Salleh, Syafiq Zikri

    2016-05-01

    Diabetes mellitus is normally characterized by chronic hyperglycemia associated with disturbances in the fat, carbohydrate, and protein metabolism. There is an increasing trend of using natural products instead of synthetic agents as alternative therapy for disorders due to their fewer side effects. In this study, antidiabetic and antioxidant activities of different Melicope lunu-ankenda (ML) ethanolic extracts were evaluated using inhibition of α-glucosidase and 2,2-diphenyl-l-picrylhydrazyl (DPPH) radicals scavenging activity, respectively; whereas, proton nuclear magnetic resonance ((1) H NMR) and ultra-high performance liquid chromatography-tandem mass spectrometric (UHPLC-MS/MS) techniques were used for metabolite profiling of ML leaf extracts at different concentrations of ethanol and water. Sixty percent of ethanolic ML extract showed highest inhibitory effect against α-glucosidase enzyme (IC50 of 37 μg/mL) and DPPH scavenging activity (IC50 of 48 μg/mL). Antidiabetic effect of ML extracts was also evaluated in vivo and it was found that the high doses (400 mg/Kg BW) of ML extract exhibited high suppression in fasting blood glucose level by 62.75%. The metabolites responsible for variation among ML samples with variable ethanolic levels have been evaluated successfully using (1) H-NMR-based metabolomics. The principal component analysis (PCA) and partial least squares(PLS) analysis scores depicted clear and distinct separations into 4 clusters representing the 4 ethanolic concentrations by PC1 and PC2, with an eigenvalue of 69.9%. Various (1) H-NMR chemical shifts related to the metabolites responsible for sample difference were also ascribed. The main bioactive compounds identified attributing toward the separation included: isorhamnetin, skimmianine, scopoletin, and melicarpinone. Hence, ML may be used as promising medicinal plant for the development of new functional foods, new generation antidiabetic drugs, as a single entity phytomedicine or in

  15. Lean mainstream schemes for Stata 8 graphics

    Svend Juul

    2003-01-01

    The new Stata 8 graphics are powerful and flexible. Now, a few months after the first release, the graphics still have some shortcomings-both in design and in the manual documenting the program-but progress is being made. The graph layout used throughout the Graphics Reference Manual has led some users to underestimate the potential of the program. This paper presents two schemes for a lean layout, conforming to the mainstream in scientific publishing. Copyright 2003 by StataCorp LP.

  16. Ambient occlusion and shadows for molecular graphics

    Easdon, Robert

    2013-01-01

    Computer based visualisations of molecules have been produced as early as the 1950s to aid researchers in their understanding of biomolecular structures. An important consideration for Molecular Graphics software is the ability to visualise the 3D structure of the molecule in a clear manner. Recent advancements in computer graphics have led to improved rendering capabilities of the visualisation tools. The capabilities of current shading languages allow the inclusion of advanced graphic ef...

  17. GRADE: a graphical programming environment for multicomputers

    Kacsuk, P.; G. Dózsa; T. Fadfyas; R. Lovas

    2012-01-01

    To provide high-level graphical support for developing message passing programs, an integrated programming environment (GRADE) is being developed. GRADE currently provides tools to construct, execute, debug, monitor and visualize message passing based parallel programs. GRADE offers the programmer an integrated graphical user interface during the whole life-cycle of program development and provides high-level graphical programming abstraction mechanisms to construct parallel applications. The...

  18. On some exact solutions of slightly variant forms of Yang's equations and their graphical representations

    Rupesh Kumar Sha; Pranab Krishna Chanda

    2008-05-01

    The equations obtained by Yang while discussing the condition of self-duality of (2) gauge fields on Euclidean four-dimensional space have been generalized. Exact solutions and their graphical representations for the generalized equation (for some particular values of the parameters) have been reported. They represent interesting physical characteristics like waves with spreading solitary profile, spreading wave packets, waves with pulsating solitary profile (between zero and a maximum), waves with oscillatory solitary profile and chaos.

  19. Guidebook to R graphics using Microsoft Windows

    Takezawa, Kunio

    2012-01-01

    Introduces the graphical capabilities of R to readers new to the software Due to its flexibility and availability, R has become the computing software of choice for statistical computing and generating graphics across various fields of research. Guidebook to R Graphics Using Microsoft® Windows offers a unique presentation of R, guiding new users through its many benefits, including the creation of high-quality graphics. Beginning with getting the program up and running, this book takes readers step by step through the process of creating histograms, boxplots, strip charts, time series gra

  20. Programming Language Software For Graphics Applications

    Beckman, Brian C.

    1993-01-01

    New approach reduces repetitive development of features common to different applications. High-level programming language and interactive environment with access to graphical hardware and software created by adding graphical commands and other constructs to standardized, general-purpose programming language, "Scheme". Designed for use in developing other software incorporating interactive computer-graphics capabilities into application programs. Provides alternative to programming entire applications in C or FORTRAN, specifically ameliorating design and implementation of complex control and data structures typifying applications with interactive graphics. Enables experimental programming and rapid development of prototype software, and yields high-level programs serving as executable versions of software-design documentation.

  1. Geometrical and Graphical Solutions of Quadratic Equations.

    Hornsby, E. John, Jr.

    1990-01-01

    Presented are several geometrical and graphical methods of solving quadratic equations. Discussed are Greek origins, Carlyle's method, von Staudt's method, fixed graph methods and imaginary solutions. (CW)

  2. Quick reference to computer graphics terms

    Stevens, Roger T

    1989-01-01

    Quick Reference to Computer Graphics Terms is a collection of technical terms used in computer graphics in a compact and convenient reference volume.The book lists a number of acronyms, phrases, and words that have specialized meanings in the field of computer graphics. The definitions provided are simple and easily understood. The author attempts to present, as much as possible, words and phrases that are widely used during the publication of the volume. Any terms not found in the book may be included in the next edition.Users of computers graphics and students will find the book useful.

  3. Solar energy in Australia: a profile of renewable energy activity in its national context

    Case, G.L.

    1980-08-01

    The following topics are included: country overview; energy summary; geopolitical, economic, and cultural aspects of Australia; the energy profile; and international agreements, contacts, manufacturers, and projects. (MHR)

  4. Activity Profiles and Physiological Responses of Representative Tag Football Players in Relation to Playing Position and Physical Fitness.

    Luke W Hogarth

    Full Text Available This study determined the physical fitness, match-activity profiles and physiological responses of representative tag football players and examined the relationship between physical fitness and the match-activity profile. Microtechnology devices and heart rate (HR chest straps were used to determine the match-activity profiles of sixteen tag football players for five matches during the 2014 Australian National Championships. The relationships between lower body muscular power, straight line running speed and Yo-Yo intermittent recovery test level 2 (Yo-Yo IR2 and the match-activity profile were examined using Pearson's correlation coefficients. Outside players had greater lower body muscular power (ES = 0.98 and straight line running speed (ES = 1.03-1.18 than inside players, and also covered greater very high-speed running (VHSR distance/min (ES = 0.67 and reached higher peak running speeds (ES = 0.95 during matches. Inside and outside players performed a similar number of repeated high-intensity effort (RHIE bouts and reported similar mean and maximum efforts per RHIE bout. However, there were differences between playing positions for mean and maximal RHIE effort durations (ES = 0.69-1.15 and mean RHIE bout recovery (ES = 0.56. Inside and outside players also reported small to moderate differences (ES = 0.43-0.80 for times spent in each HR zone. There were a number of moderate to very large correlations between physical fitness measures and match-activity profile variables. This study found lower body muscular power, straight line running speed and Yo-Yo IR2 to be related to the match-activities of representative tag football players, although differences between inside and outside players suggest that athlete testing and training practices should be modified for different playing positions.

  5. Antioxidant activity, fatty acid profile and tocopherols of Tamarindus indica L. seeds

    Débora Maria Moreno Luzia

    2011-06-01

    Full Text Available This study aimed to characterize Tamarindus indica L. seeds regarding its composition and to evaluate its antioxidant potential, fatty acid profile and content of tocopherols. In order to obtain the extract, the dried and crushed seeds were extracted with ethanol for 30 minutes in a 1:3 seeds: ethanol ratio under continuous stirring at room temperature. After that, the mixtures were filtered and subjected to roto-evaporation at 40 ºC in order to determine, through direct weighing, the dry matter yields of the extracts. According to the results, Tamarindus indica L. seeds showed high content of total carbohydrates (71.91% and offered relevant content and antioxidant activity of phenolic compounds. Tamarindus indica L. seeds oil presents high oxidative stability (15.83 hours and significant total tocopherol content (57.77 mg.kg-1, besides presenting a higher percentage of unsaturated fatty acids - the main component being linolenic (59.61%, which is considered an essential fatty acid.

  6. Kinetics of cytokine profile in response to Mycobacterium bovis BCG and Streptococcus pyogenes activated cells

    Verma, Vivek; Kumar, Parveen; Dhanda, Rakesh Singh; Yadav, Manisha

    2016-01-01

    The infection of epithelial cells is a necessary step for Mycobacterium bovis BCG dissemination, but the mechanism of mycobacterial epithelial interactions is not completely understood. Similarly, Streptococcus pyogenes is a strictly human pathogen that favorably colonizes the skin and the pharynx. Effective cytokine secretion is essential in order to fabricate a suitable inflammatory response against an infection. In this data article, the cytokine profile in BCG and S. pyogenes activated THP-1 cell line in media after the acute phase of infection by ELISA is described. The interleukin-8 level was increased in response to both BCG and S. pyogenes, but was quite prominent after 24 h and further increased upto 72 h post infection. On the other hand, an increase in IL-6 response to S. pyogenes was observed while there was no response to BCG even after 48 h of infection. A low level of TNF-α was detected upon BCG and S. pyogenes infection. PMID:27014727

  7. Chemical Profile, Antioxidant and Antibacterial Activities of Achillea moschata Wulfen, an Endemic Species from the Alps

    Sara Vitalini

    2016-06-01

    Full Text Available Aerial parts of Achillea moschata Wulfen (Asteraceae growing wild in the Italian Rhaetian Alps were investigated to describe, for the first time, their phenolic content, as well as to characterize the essential oil. Inspection of the metabolic profile combining HPLC-DAD and ESI-MS/MS data showed that the methanol extract contained glycosylated flavonoids with luteolin and apigenin as the main aglycones. Among them, the major compound was 7-O-glucosyl apigenin. Caffeoyl derivates were other phenolics identified. The essential oil obtained by steam distillation and investigated by GC/FID and GC/MS showed camphor, 1,8-cineole, and bornylacetate as the main constituents. The antioxidant capacity of three different extracts with increasing polarity and of the essential oil was evaluated by employing ABTS·+ and DPPH· radical scavenging assays. The methanolic extract was the only significantly effective sample against both synthetic radicals. All samples were also tested against Gram-positive (Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus and Gram-negative (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa bacterial species using the disk diffusion assay. The non-polar extracts (dichloromethane and petroleum ether and the essential oil possessed a broad spectrum of antimicrobial activity expressed according to inhibition zone diameter (8–24 mm.

  8. Kinetics of cytokine profile in response to Mycobacterium bovis BCG and Streptococcus pyogenes activated cells.

    Verma, Vivek; Kumar, Parveen; Dhanda, Rakesh Singh; Yadav, Manisha

    2016-06-01

    The infection of epithelial cells is a necessary step for Mycobacterium bovis BCG dissemination, but the mechanism of mycobacterial epithelial interactions is not completely understood. Similarly, Streptococcus pyogenes is a strictly human pathogen that favorably colonizes the skin and the pharynx. Effective cytokine secretion is essential in order to fabricate a suitable inflammatory response against an infection. In this data article, the cytokine profile in BCG and S. pyogenes activated THP-1 cell line in media after the acute phase of infection by ELISA is described. The interleukin-8 level was increased in response to both BCG and S. pyogenes, but was quite prominent after 24 h and further increased upto 72 h post infection. On the other hand, an increase in IL-6 response to S. pyogenes was observed while there was no response to BCG even after 48 h of infection. A low level of TNF-α was detected upon BCG and S. pyogenes infection. PMID:27014727

  9. Chemical Profile, Antioxidant and Antibacterial Activities of Achillea moschata Wulfen, an Endemic Species from the Alps.

    Vitalini, Sara; Madeo, Moira; Tava, Aldo; Iriti, Marcello; Vallone, Lisa; Avato, Pinarosa; Cocuzza, Clementina Elvezia; Simonetti, Paolo; Argentieri, Maria Pia

    2016-01-01

    Aerial parts of Achillea moschata Wulfen (Asteraceae) growing wild in the Italian Rhaetian Alps were investigated to describe, for the first time, their phenolic content, as well as to characterize the essential oil. Inspection of the metabolic profile combining HPLC-DAD and ESI-MS/MS data showed that the methanol extract contained glycosylated flavonoids with luteolin and apigenin as the main aglycones. Among them, the major compound was 7-O-glucosyl apigenin. Caffeoyl derivates were other phenolics identified. The essential oil obtained by steam distillation and investigated by GC/FID and GC/MS showed camphor, 1,8-cineole, and bornylacetate as the main constituents. The antioxidant capacity of three different extracts with increasing polarity and of the essential oil was evaluated by employing ABTS·+ and DPPH· radical scavenging assays. The methanolic extract was the only significantly effective sample against both synthetic radicals. All samples were also tested against Gram-positive (Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa) bacterial species using the disk diffusion assay. The non-polar extracts (dichloromethane and petroleum ether) and the essential oil possessed a broad spectrum of antimicrobial activity expressed according to inhibition zone diameter (8-24 mm). PMID:27347915

  10. Application of passive (SPATT) and active sampling methods in the profiling and monitoring of marine biotoxins.

    McCarthy, Moira; van Pelt, Frank N A M; Bane, Vaishali; O'Halloran, John; Furey, Ambrose

    2014-10-01

    Solid phase adsorbent and toxin tracking (SPATT) enables temporally and spatially integrated monitoring of biotoxins in aquatic environments. Monitoring using two adsorbent resins was performed over a four-month period at Lough Hyne Marine Reserve, Ireland. A range of Diarhettic Shellfish Poisoning (DSP) toxins were detected from SPATT extracts throughout the study period. The majority of biotoxins were detected in the top 20-30 m of the water column and a spike in toxin accumulation was measured during August 2010. Phytoplankton analysis confirmed the presence of toxin-producing species Dinophysis acuta and Dinophysis acuminata during the bloom. SPATT has the potential to provide useful information on phycotoxin distribution in the water column; enabling evidence-based decisions regarding appropriate depths for obtaining phytoplankton and shellfish samples in marine biotoxin monitoring programmes. Active sampling was performed continuously over 7-days and high quantities of toxins were successfully accumulated in the HP-20 resin, okadaic acid (∼13 mg), dinophysis toxin-2 (∼29 mg), pectenotoxin-2 (∼20 mg) and pectenotoxin-2-seco acid (∼6 mg) proving this an effective method for accumulating DSP toxins from the marine environment. The method has potential application as a tool for assessing toxin profiles at proposed shellfish harvesting sites. PMID:25064272

  11. Changes in Coronary Heart Disease Risk Profile of Adults with Intellectual Disabilities following a Physical Activity Intervention

    Moss, S. J.

    2009-01-01

    Background: Regular physical activity is one of the modifiable risk factors for coronary heart disease (CHD). With an increasing age profile and similar patterns of morbidity to the general population, persons with intellectual disabilities (ID) and their caregivers would benefit from data that indicate CHD risk factors. Knowledge of the CHD risk…

  12. Global endometrial transcriptomic profiling: transient immune activation precedes tissue proliferation and repair in healthy beef cows

    Foley Cathriona

    2012-09-01

    Full Text Available Abstract Background All cows experience bacterial contamination and tissue injury in the uterus postpartum, instigating a local inflammatory immune response. However mechanisms that control inflammation and achieve a physiologically functioning endometrium, while avoiding disease in the postpartum cow are not succinctly defined. This study aimed to identify novel candidate genes indicative of inflammation resolution during involution in healthy beef cows. Previous histological analysis of the endometrium revealed elevated inflammation 15 days postpartum (DPP which was significantly decreased by 30 DPP. The current study generated a genome-wide transcriptomic profile of endometrial biopsies from these cows at both time points using mRNA-Seq. The pathway analysis tool GoSeq identified KEGG pathways enriched by significantly differentially expressed genes at both time points. Novel candidate genes associated with inflammatory resolution were subsequently validated in additional postpartum animals using quantitative real-time PCR (qRT-PCR. Results mRNA-Seq revealed 1,107 significantly differentially expressed genes, 73 of which were increased 15 DPP and 1,034 were increased 30 DPP. Early postpartum, enriched immune pathways (adjusted P P SAA1/2, GATA2, IGF1, SHC2, and SERPINA14 genes were significantly elevated 30 DPP and are functionally associated with tissue repair and the restoration of uterine homeostasis postpartum. Conclusions The results of this study reveal an early activation of the immune response which undergoes a temporal functional change toward tissue proliferation and regeneration during endometrial involution in healthy postpartum cows. These molecular changes mirror the activation and resolution of endometrial inflammation during involution previously classified by the degree of neutrophil infiltration. SAA1/2, GATA2, IGF1, SHC2, and SERPINA14 genes may become potential markers for resolution of endometrial inflammation in

  13. Phenolic Profile and Antioxidant Activity of Pulp and Peel from Peach and Nectarine Fruits

    Branka T. STOJANOVIC

    2016-06-01

    Full Text Available Peach (Prunus persica L. is a fruit of high nutritional and economic value. Carbohydrates, dietary fibers, minerals and organic acids are among the major constituents of peach fruit, which contribute to the nutritional quality of both fresh fruits and juice. Polyphenolic compounds found in peach may play an important role in physiological functions related to human health. Different polyphenolics may have varied biological activities including antioxidant activity. In this study antioxidant characteristics between peel and pulp of different peach cultivars (‘Radmilovčanka’, ‘June Gold’, ‘Blake’, ‘Hale’, ‘Vesna’, ‘Adria’ and one of nectarine (‘Fantasia’ were investigated. The peel and pulp extracts showed a huge amount of total phenolics (TP, total flavonoids (TF, total hydroxycinnamates (TH and total flavonols (TFL, ranging from 42.7-211.4, 11.1-128.5 mg GAE/100 g fresh weight (f.w. (TP, 21.9 -94.9, 5.0-58.9 mg CE/100 g f.w. (TF, 28.4-389.2, 8.5-165.8 mg kg-1 f.w. (TH and 17.3-54 mg kg-1 f.w. (TFL. High contents of phenolic compounds were significantly correlated with high antioxidant capacities. Peach pulp and peel differ significantly in their phenolic profiles: the pulp contains mainly chlorogenic, neochlorogenic and p-coumaric acids, whereas the peel possesses chlorogenic, neochlorogenic and p-coumaric acids together with several flavonol glycosides in huge amounts. Our results indicate that cultivar and extraction solvent play important roles in phenolic compositions and antioxidant properties of peach and nectarine extracts, which was shown using statistical analysis (ANOVA. There are high correlations between extracted phenolic compounds and peach and nectarine cultivars, and used solvent and part of the fruit (peel and pulp.

  14. Comparison between the International Physical Activity Questionnaire and the American College of Sports Medicine/American Heart Association criteria to classify the physical activity profile in adults

    Suzana Alves de Moraes

    2013-07-01

    Full Text Available OBJECTIVE: the study aims to evaluate the reproducibility between the International Physical Activity Questionnaire and the American College of Sports Medicine/American Heart Association criteria to classify the physical activity profile in an adult population living in Ribeirão Preto, SP, Brazil. METHODS: population-based cross-sectional study, including 930 adults of both genders. The reliability was evaluated by Kappa statistics, estimated according to socio-demographic strata. RESULTS: the kappa estimates showed good agreement between the two criteria in all strata. However, higher prevalence of "actives" was found by using the American College of Sports Medicine/American Heart Association. CONCLUSIONS: although the estimates have indicated good agreement, the findings suggest caution in choosing the criteria to classify physical activity profile mainly when "walking" is the main modality of physical activity.

  15. 创意思维与图形设计%Creative Thinking and Graphic Design

    葛饶民

    2004-01-01

    In commercial activities, graphic design needs to be effective in its visual language in order to accurately communicate its message to consumers. To achieve this, designers need creative thinking, among which diffusible thinking and retrorse thinking are of the first importance. This article analyzes the various factors and methods needed to be considered during the creative graphic design.

  16. Using Interactive Graphics to Teach Multivariate Data Analysis to Psychology Students

    Valero-Mora, Pedro M.; Ledesma, Ruben D.

    2011-01-01

    This paper discusses the use of interactive graphics to teach multivariate data analysis to Psychology students. Three techniques are explored through separate activities: parallel coordinates/boxplots; principal components/exploratory factor analysis; and cluster analysis. With interactive graphics, students may perform important parts of the…

  17. Evaluation of Antioxidant, Antidiabetic and Anticholinesterase Activities of Smallanthus sonchifolius Landraces and Correlation with Their Phytochemical Profiles

    Daniela Russo; Patrícia Valentão; Andrade, Paula B.; Fernandez, Eloy C.; Luigi Milella

    2015-01-01

    The present study aimed to investigate the phytochemical profile of leaf methanol extracts of fourteen Smallanthus sonchifolius (yacon) landraces and their antioxidant, anticholinesterase and antidiabetic activities that could lead to the finding of more effective agents for the treatment and management of Alzheimer’s disease and diabetes. For this purpose, antioxidant activity was assessed using different tests: ferric reducing ability power (FRAP), 2,2-diphenyl-1-picryl hydrazyl (DPPH), ...

  18. Comparison of the free and bound phenolic profiles and cellular antioxidant activities of litchi pulp extracts from different solvents

    Su, Dongxiao; Zhang, Ruifen; Hou, Fangli; Zhang, Mingwei; Guo, Jinxin; Huang, Fei; Deng, Yuanyuan; Wei, Zhencheng

    2014-01-01

    Background The phenolic contents and antioxidant activities of fruits could be underestimated if the bound phenolic compounds are not considered. In the present study, the extraction efficiencies of various solvents were investigated in terms of the total content of the free and bound phenolic compounds, as well as the phenolic profiles and antioxidant activities of the extracts. Methods Five different solvent mixtures were used to extract the free phenolic compounds from litchi pulp. Alkalin...

  19. EFFECTS OF INTERFERON THERAPY UPON IMMUNE MARKER PROFILE AND ENZYMATIC ACTIVITY IN PERIPHERAL BLOOD LYMPHOCYTES OF PATIENTS WITH RENAL CANCER

    L. M. Kurtasova

    2014-01-01

    Full Text Available We have observed forty-four patients with metastatic renal cancer before and after interferon therapy. Immune markers of of peripheral blood lymphocytes were determined by flow cytometry. Activity of NAD (P-dependent dehydrogenase in blood lymphocytes was studied by means of bioluminescence technique. Changes of immune marker profiles and enzymatic activities of peripheral blood lymphocytes were found in patients with renal cancer after a course of interferon therapy.

  20. ERB - Graphic knowledge base editor

    The paper describes the present state and future prospects of the Expert System for Operator Support (ESOS) developed at the Nuclear Research Institute at Rez near Prague (NRI). Special emphasis is put on knowledge acquisition and knowledge base representation means - ERB. ERB is a package of programs, which enables the user to create, edit and compile a knowledge base of the Expert System RECON, to create and edit testing data and to test knowledge base (KB). The knowledge base is displayed in the form of a graph, where nodes represent the rules and arcs represent the relations ''PREDECESSOR→SUCCESSOR''. The filling of KB is integrated with the design of their graphical representation. Owing to this, the form of the KB representation makes the whole KB more understandable. The filling process of KB corresponds with general methodologies, where in the first step nodes with identifiers and texts are defined, in the second step relations between them are specified, in the third step the predecessor is defined and finally, relations between nodes are concretized. The paper contains a description of the functions offered by the ERB. (author). 2 refs, 5 figs

  1. Graphic design as urban design: towards a theory for analysing graphic objects in urban environments.

    Harland, Robert George

    2011-01-01

    This thesis presents a model for analysing the graphic object as urban object, by considering atypical fields of discourse that contribute to the formation of the object domain. The question: what is graphic design as urban design? directs the research through an epistemological design study comprising: an interrogation of graphic design studio practice and the articulation of graphic design research questions; a review and subsequent development of research strategy, design and method toward...

  2. Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors

    Mattsson, Anna; Kärrman, Anna; Pinto, Rui; Brunström, Björn

    2015-01-01

    Untargeted metabolic profiling of body fluids in experimental animals and humans exposed to chemicals may reveal early signs of toxicity and indicate toxicity pathways. Avian embryos develop separately from their mothers, which gives unique possibilities to study effects of chemicals during embryo development with minimal confounding factors from the mother. In this study we explored blood plasma and allantoic fluid from chicken embryos as matrices for revealing metabolic changes caused by exposure to chemicals during embryonic development. Embryos were exposed via egg injection on day 7 to the environmental pollutant perfluorooctanoic acid (PFOA), and effects on the metabolic profile on day 12 were compared with those caused by GW7647 and rosiglitazone, which are selective agonists to peroxisome-proliferator activated receptor α (PPARα) and PPARγ, respectively. Analysis of the metabolite concentrations from allantoic fluid by Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) showed clear separation between the embryos exposed to GW7647, rosiglitazone, and vehicle control, respectively. In blood plasma only GW7647 caused a significant effect on the metabolic profile. PFOA induced embryo mortality and increased relative liver weight at the highest dose. Sublethal doses of PFOA did not significantly affect the metabolic profile in either matrix, although single metabolites appeared to be altered. Neonatal mortality by PFOA in the mouse has been suggested to be mediated via activation of PPARα. However, we found no similarity in the metabolite profile of chicken embryos exposed to PFOA with those of embryos exposed to PPAR agonists. This indicates that PFOA does not activate PPAR pathways in our model at concentrations in eggs and embryos well above those found in wild birds. The present study suggests that allantoic fluid and plasma from chicken embryos are useful and complementary matrices for exploring effects on the metabolic profile resulting

  3. Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors.

    Mattsson, Anna; Kärrman, Anna; Pinto, Rui; Brunström, Björn

    2015-01-01

    Untargeted metabolic profiling of body fluids in experimental animals and humans exposed to chemicals may reveal early signs of toxicity and indicate toxicity pathways. Avian embryos develop separately from their mothers, which gives unique possibilities to study effects of chemicals during embryo development with minimal confounding factors from the mother. In this study we explored blood plasma and allantoic fluid from chicken embryos as matrices for revealing metabolic changes caused by exposure to chemicals during embryonic development. Embryos were exposed via egg injection on day 7 to the environmental pollutant perfluorooctanoic acid (PFOA), and effects on the metabolic profile on day 12 were compared with those caused by GW7647 and rosiglitazone, which are selective agonists to peroxisome-proliferator activated receptor α (PPARα) and PPARγ, respectively. Analysis of the metabolite concentrations from allantoic fluid by Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA) showed clear separation between the embryos exposed to GW7647, rosiglitazone, and vehicle control, respectively. In blood plasma only GW7647 caused a significant effect on the metabolic profile. PFOA induced embryo mortality and increased relative liver weight at the highest dose. Sublethal doses of PFOA did not significantly affect the metabolic profile in either matrix, although single metabolites appeared to be altered. Neonatal mortality by PFOA in the mouse has been suggested to be mediated via activation of PPARα. However, we found no similarity in the metabolite profile of chicken embryos exposed to PFOA with those of embryos exposed to PPAR agonists. This indicates that PFOA does not activate PPAR pathways in our model at concentrations in eggs and embryos well above those found in wild birds. The present study suggests that allantoic fluid and plasma from chicken embryos are useful and complementary matrices for exploring effects on the metabolic profile resulting

  4. Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA and Agonists to Peroxisome Proliferator-Activated Receptors.

    Anna Mattsson

    Full Text Available Untargeted metabolic profiling of body fluids in experimental animals and humans exposed to chemicals may reveal early signs of toxicity and indicate toxicity pathways. Avian embryos develop separately from their mothers, which gives unique possibilities to study effects of chemicals during embryo development with minimal confounding factors from the mother. In this study we explored blood plasma and allantoic fluid from chicken embryos as matrices for revealing metabolic changes caused by exposure to chemicals during embryonic development. Embryos were exposed via egg injection on day 7 to the environmental pollutant perfluorooctanoic acid (PFOA, and effects on the metabolic profile on day 12 were compared with those caused by GW7647 and rosiglitazone, which are selective agonists to peroxisome-proliferator activated receptor α (PPARα and PPARγ, respectively. Analysis of the metabolite concentrations from allantoic fluid by Orthogonal Partial Least Squares Discriminant Analysis (OPLS-DA showed clear separation between the embryos exposed to GW7647, rosiglitazone, and vehicle control, respectively. In blood plasma only GW7647 caused a significant effect on the metabolic profile. PFOA induced embryo mortality and increased relative liver weight at the highest dose. Sublethal doses of PFOA did not significantly affect the metabolic profile in either matrix, although single metabolites appeared to be altered. Neonatal mortality by PFOA in the mouse has been suggested to be mediated via activation of PPARα. However, we found no similarity in the metabolite profile of chicken embryos exposed to PFOA with those of embryos exposed to PPAR agonists. This indicates that PFOA does not activate PPAR pathways in our model at concentrations in eggs and embryos well above those found in wild birds. The present study suggests that allantoic fluid and plasma from chicken embryos are useful and complementary matrices for exploring effects on the metabolic

  5. Using Typography Grid in Graphic Design

    张悦霞

    2007-01-01

    Typography grid is one of the important tools in the process of graphic design. Thought studying the history and principles of typography grid, we can know and master the methods of design and improve understanding of the aesthetics rules of graphic design.

  6. Interactive graphical computer-aided design system

    Edge, T. M.

    1975-01-01

    System is used for design, layout, and modification of large-scale-integrated (LSI) metal-oxide semiconductor (MOS) arrays. System is structured around small computer which provides real-time support for graphics storage display unit with keyboard, slave display unit, hard copy unit, and graphics tablet for designer/computer interface.

  7. Mastering probabilistic graphical models using Python

    Ankan, Ankur

    2015-01-01

    If you are a researcher or a machine learning enthusiast, or are working in the data science field and have a basic idea of Bayesian learning or probabilistic graphical models, this book will help you to understand the details of graphical models and use them in your data science problems.

  8. Graphic Design in Libraries: A Conceptual Process

    Ruiz, Miguel

    2014-01-01

    Providing successful library services requires efficient and effective communication with users; therefore, it is important that content creators who develop visual materials understand key components of design and, specifically, develop a holistic graphic design process. Graphic design, as a form of visual communication, is the process of…

  9. Standards of Multimedia Graphic Design in Education

    Aldalalah, Osamah Ahmad; Ababneh, Ziad Waleed Mohamed

    2015-01-01

    This study aims to determine Standards of Multimedia Graphic Design in Education through the analysis of the theoretical basis and previous studies related to this subject. This study has identified the list of standards of Multimedia, Graphic Design, each of which has a set indicator through which the quality of Multimedia can be evaluated in…

  10. Spatial Ability through Engineering Graphics Education

    Marunic, Gordana; Glazar, Vladimir

    2013-01-01

    Spatial ability has been confirmed to be of particular importance for successful engineering graphics education and to be a component of human intelligence that can be improved through instruction and training. Consequently, the creation and communication by means of graphics demand careful development of spatial skills provided by the balanced…

  11. Graphic lambda calculus and knot diagrams

    Buliga, Marius

    2012-01-01

    In arXiv:1207.0332 [cs.LO] was proposed a graphic lambda calculus formalism, which has sectors corresponding to untyped lambda calculus and emergent algebras. Here we explore the sector covering knot diagrams, which are constructed as macros over the graphic lambda calculus.

  12. Teaching Media Literacy with Graphic Novels

    Monnin, Katie

    2010-01-01

    Background: A current problem in media literacy studies is whether or not to categorize graphic novels as media literacy texts. Thus, this article begins with a review of current media literacy research and its emphasis on defining media literacy texts as texts that rely on both print literacies and image literacies. Because graphic novels rely on…

  13. Exploring Literary Devices in Graphic Novels

    Dallacqua, Ashley K.

    2012-01-01

    This article explores the possibilities of graphic novels with young readers. During the 2009-2010 school year, while working with four fifth-grade students, the author examined the question "In what ways do readers engage while reading a graphic novel?" The fifth graders took part in book discussions and one-on-one interviews after reading two…

  14. Imagined Spaces: Motion Graphics in Performance Spaces

    Steijn, Arthur

    2016-01-01

    In this chapter I introduce the first steps in my work with adjoining and developing concepts relevant to the study and practical design of motion graphics in spatial experience design; performance, event and exhibition design. Based on a presentation of a practical case where motion graphics...... are used in performance design, the chapter portrays the work in progress on a design model for designing spatial experiences in performances through the use of motion graphics. The purpose of the model is to systematize and categorize different design elements e.g. space, line and shape, tone, colour......, space, movement, and rhythm, in relation to e.g. expression and atmosphere, to be considered when designing and analyzing motion graphics in performance design, one kind of spatial experience design. The analysis of the case, here a dance performance utilizing video projected motion graphics, isbe done...

  15. DS86 neutron dose: Monte Carlo analysis for depth profile of 152Eu activity in a large stone sample.

    Endo, S; Iwatani, K; Oka, T; Hoshi, M; Shizuma, K; Imanaka, T; Takada, J; Fujita, S; Hasai, H

    1999-06-01

    The depth profile of 152Eu activity induced in a large granite stone pillar by Hiroshima atomic bomb neutrons was calculated by a Monte Carlo N-Particle Transport Code (MCNP). The pillar was on the Motoyasu Bridge, located at a distance of 132 m (WSW) from the hypocenter. It was a square column with a horizontal sectional size of 82.5 cm x 82.5 cm and height of 179 cm. Twenty-one cells from the north to south surface at the central height of the column were specified for the calculation and 152Eu activities for each cell were calculated. The incident neutron spectrum was assumed to be the angular fluence data of the Dosimetry System 1986 (DS86). The angular dependence of the spectrum was taken into account by dividing the whole solid angle into twenty-six directions. The calculated depth profile of specific activity did not agree with the measured profile. A discrepancy was found in the absolute values at each depth with a mean multiplication factor of 0.58 and also in the shape of the relative profile. The results indicated that a reassessment of the neutron energy spectrum in DS86 is required for correct dose estimation. PMID:10494148

  16. Managing facts and concepts: computer graphics and information graphics from a graphic designer's perspective

    Marcus, A.

    1983-01-01

    This book emphasizes the importance of graphic design for an information-oriented society. In an environment in which many new graphic communication technologies are emerging, it raises some issues which graphic designers and managers of graphic design production should consider in using the new technology effectively. In its final sections, it gives an example of the steps taken in designing a visual narrative as a prototype for responsible information-oriented graphic design. The management of complex facts and concepts, of complex systems of ideas and issues, presented in a visual as well as verbal narrative or dialogue and conveyed through new technology will challenge the graphic design community in the coming decades. This shift to visual-verbal communication has repercussions in the educational system and the political/governance systems that go beyond the scope of this book. If there is a single goal for this book, it is to stimulate the reader and then to provide references that will help you learn more about graphic design in an era of communication when know business is show business.

  17. ENZYMATIC ACTIVITY AND ANTIBIOTIC RESISTANCE PROFILE OF LACTOBACILLUS PARACASEI SSP. PARACASEI-1 ISOLATED FROM REGIONAL YOGURTS OF BANGLADESH

    Ummay Honi

    2013-12-01

    Full Text Available Lactobacillus paracasei ssp. paracasei-1 was identified from traditional yogurts of Khulna region, Bangladesh and its enzyme and antibiotic resistance profiles were determined. A commercially available API Zym kit was employed to determine the activities of 19 different enzymes. We found that L. paracasei ssp. paracasei-1 showed strong activities for several enzymes, viz. leucine arylamidase, valine arylamidase, napthol-AS-BI-phosphohydrolase, β-galactosidase, α –Glucosidase, N-Acetyl- β- glucosaminidase while activities for other enzymes were absent. Antibiotic resistance profile was assessed by minimum inhibitory concentration (MIC test for 61 major antibiotics and 4 antifungal agents obtained from commercial sources in MRS Agar media. The strain generally showed resistance to gram negative spectrum antibiotic while it showed susceptibility towards β-lactam antibiotic to gram positive spectrum antibiotic. The findings provide the therapeutic basis of using L. paracasei ssp. paracasei-1 in finished food products.

  18. A conceptual framework for a sports knee injury performance profile (SKIPP and return to activity criteria (RTAC

    David Logerstedt

    2015-10-01

    Full Text Available ABSTRACTInjuries to the knee, including intra-articular fractures, ligamentous ruptures, and meniscal and articular cartilage lesions, are commonplace within sports. Despite advancements in surgical techniques and enhanced rehabilitation, athletes returning to cutting, pivoting, and jumping sports after a knee injury are at greater risk of sustaining a second injury. The clinical utility of objective criteria presents a decision-making challenge to ensure athletes are fully rehabilitated and safe to return to sport. A system centered on specific indicators that can be used to develop a comprehensive profile to monitor rehabilitation progression and to establish return to activity criteria is recommended to clear athletes to begin a progressive and systematic approach to activities and sports. Integration of a sports knee injury performance profile with return to activity criteria can guide clinicians in facilitating an athlete's safe return to sport, prevention of subsequent injury, and life-long knee joint health.

  19. Atividade moluscicida de plantas: uma alternativa profilática Plant molluscicidal activity: a prophylactic alternative

    Selma Patrícia D. Cantanhede

    2010-05-01

    Full Text Available Uma das formas de combate a helmintos que possuem moluscos em seu ciclo biológico é o controle da população malacológica. A tentativa de combater os criadouros naturais de hospedeiros intermediários, através de moluscicidas, tem sido uma das formas almejadas para a redução da incidência de enfermidades, como as esquistossomoses e fascioloses. Essa medida epidemiológica tem se concretizado através da utilização dos moluscicidas sintéticos que, dentre outras desvantagens, trazem danos ao ecossistema. Visando a obtenção de novos compostos, os estudos sobre a potencialidade de produtos naturais moluscicidas têm crescido consideravelmente. Alguns pesquisadores apontam os moluscicidas vegetais como fontes alternativas para o tratamento profilático de parasitoses. Tendo em vista a abrangência, endemicidade e relevância, este trabalho revela um maior enfoque à atividade moluscicida de plantas relacionada às esquistossomíases.An effective way to combat helminthes having mollusk in their life cycle is by controlling their population. The attempt to battle the natural breeding of intermediary hosts through molluscicides has been the targeted approach to reduce the incidence of such diseases as schistosomiasis and fascioloses. This epidemiological measure has been performed using synthetic molluscicides which, among other drawbacks, cause damages to the ecosystem. In order to obtain new compounds, studies on the potential of natural molluscicides products are increasing. Researchers draw attention to molluscicides plants as alternative sources for the prophylactic management of parasitoses. In view of the scope, significance and endemism, the present work highlights plant activities related to schistosomiasis.

  20. Solar energy in Argentina: a profile of renewable energy activity in its national context

    Hawkins, D.

    1981-01-01

    The following subjects are included: the country overview; the energy summary; the geopolitical, economic, and cultural aspects of the Republic of Argentina; the energy profile; and international contacts, manufacturers, and projects. (MHR)

  1. Effect of increased yeast alcohol acetyltransferase activity on flavor profiles of wine and distillates.

    Lilly, M; Lambrechts, M G; Pretorius, I S

    2000-02-01

    The distinctive flavor of wine, brandy, and other grape-derived alcoholic beverages is affected by many compounds, including esters produced during alcoholic fermentation. The characteristic fruity odors of the fermentation bouquet are primarily due to a mixture of hexyl acetate, ethyl caproate (apple-like aroma), iso-amyl acetate (banana-like aroma), ethyl caprylate (apple-like aroma), and 2-phenylethyl acetate (fruity, flowery flavor with a honey note). The objective of this study was to investigate the feasibility of improving the aroma of wine and distillates by overexpressing one of the endogenous yeast genes that controls acetate ester production during fermentation. The synthesis of acetate esters by the wine yeast Saccharomyces cerevisiae during fermentation is ascribed to at least three acetyltransferase activities, namely, alcohol acetyltransferase (AAT), ethanol acetyltransferase, and iso-amyl AAT. To investigate the effect of increased AAT activity on the sensory quality of Chenin blanc wines and distillates from Colombar base wines, we have overexpressed the alcohol acetyltransferase gene (ATF1) of S. cerevisiae. The ATF1 gene, located on chromosome XV, was cloned from a widely used commercial wine yeast strain of S. cerevisiae, VIN13, and placed under the control of the constitutive yeast phosphoglycerate kinase gene (PGK1) promoter and terminator. Chromoblot analysis confirmed the integration of the modified copy of ATF1 into the genome of three commercial wine yeast strains (VIN7, VIN13, and WE228). Northern blot analysis indicated constitutive expression of ATF1 at high levels in these yeast transformants. The levels of ethyl acetate, iso-amyl acetate, and 2-phenylethyl acetate increased 3- to 10-fold, 3.8- to 12-fold, and 2- to 10-fold, respectively, depending on the fermentation temperature, cultivar, and yeast strain used. The concentrations of ethyl caprate, ethyl caprylate, and hexyl acetate only showed minor changes, whereas the acetic acid

  2. Comparing the cloud vertical structure derived from several methods based on measured atmospheric profiles and active surface measurements

    M. Costa-Surós

    2013-06-01

    Full Text Available The cloud vertical distribution and especially the cloud base height, which is linked to cloud type, is an important characteristic in order to describe the impact of clouds in a changing climate. In this work several methods to estimate the cloud vertical structure (CVS based on atmospheric sounding profiles are compared, considering number and position of cloud layers, with a ground based system which is taken as a reference: the Active Remote Sensing of Clouds (ARSCL. All methods establish some conditions on the relative humidity, and differ on the use of other variables, the thresholds applied, or the vertical resolution of the profile. In this study these methods are applied to 125 radiosonde profiles acquired at the ARM Southern Great Plains site during all seasons of year 2009 and endorsed by GOES images, to confirm that the cloudiness conditions are homogeneous enough across their trajectory. The overall agreement for the methods ranges between 44–88%; four methods produce total agreements around 85%. Further tests and improvements are applied on one of these methods. In addition, we attempt to make this method suitable for low resolution vertical profiles, which could be useful in atmospheric modeling. The total agreement, even when using low resolution profiles, can be improved up to 91% if the thresholds for a moist layer to become a cloud layer are modified to minimize false negatives with the current data set, thus improving overall agreement.

  3. Motivational Profiles for Physical Activity Practice in Adults with Type 2 Diabetes: A Self-Determination Theory Perspective.

    Gourlan, Mathieu; Trouilloud, David; Boiché, Julie

    2016-01-01

    Drawing on Self-Determination Theory, this study explored the motivational profiles toward Physical Activity (PA) among adults with type 2 diabetes and the relationships between motivational profile, perceived competence and PA. Participants were 350 men and women (Mean age 62.77 years) who were interviewed on their motivations toward PA, perceived level of competence to practice, and PA practice. Cluster analyses reveal the existence of three distinct profiles: "High Combined" (ie, high scores on motivations ranging from intrinsic to external regulation, moderate level on amotivation), "Self-Determined" (ie, high scores on intrinsic, integrated, and identified regulations; low scores on other regulations), and "Moderate" (ie, moderate scores on all regulations). Participants with "High Combined" and "Self-Determined" profiles reported higher perceived competence and longer leisure-time PA practice in comparison to those with a "Moderate" profile. This study highlights the necessity of adopting a person-centered approach to better understand motivation toward PA among type 2 diabetics. PMID:25961448

  4. Development of a fluorescent microsphere-based multiplexed high-throughput assay system for profiling of transcription factor activation.

    Yaoi, Takuro; Jiang, Xin; Li, Xianqiang

    2006-06-01

    Transcription factors (TFs), which play crucial roles in the regulation of gene expression in the human genome, are highly regulated by a variety of mechanisms. A single extracellular stimulus can trigger multiple signaling pathways, and these in turn can activate multiple TFs to mediate the inducible expression of target genes. Alterations in the activities of TFs are often associated with human diseases, such as altered activating factor 1, estrogen receptor, and p53 function in cancer, nuclear factor kappaB in inflammatory diseases, and peroxisome proliferator-activated receptor gamma in obesity. A systematic assay for profiling the activation of TFs will aid in elucidating the mechanisms of TF activation, reveal altered TFs associated with human diseases, and aid in developing assays for drug discovery. Here, we developed a 24-plex fluorescent microsphere-based TF activation assay system with a 96-well plate format. The assay system enabled high-throughput profiling of the DNA binding activity of TFs in multiple samples with high sensitivity. PMID:16834534

  5. Comparative phenolic compound profiles and antioxidative activity of the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) according to cultivation years

    Chung, Ill-Min; Lim, Ju-Jin; Ahn, Mun-Seob; Jeong, Haet-Nim; An, Tae-Jin; Kim, Seung-Hyun

    2015-01-01

    Background The study of phenolic compounds profiles and antioxidative activity in ginseng fruit, leaves, and roots with respect to cultivation years, and has been little reported to date. Hence, this study examined the phenolic compounds profiles and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free-radical-scavenging activities in the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) as a function of cultivation year. Methods Profiling of 23 phenolic compounds in ginseng fruit, leave...

  6. Accelerating VASP electronic structure calculations using graphic processing units

    Hacene, Mohamed

    2012-08-20

    We present a way to improve the performance of the electronic structure Vienna Ab initio Simulation Package (VASP) program. We show that high-performance computers equipped with graphics processing units (GPUs) as accelerators may reduce drastically the computation time when offloading these sections to the graphic chips. The procedure consists of (i) profiling the performance of the code to isolate the time-consuming parts, (ii) rewriting these so that the algorithms become better-suited for the chosen graphic accelerator, and (iii) optimizing memory traffic between the host computer and the GPU accelerator. We chose to accelerate VASP with NVIDIA GPU using CUDA. We compare the GPU and original versions of VASP by evaluating the Davidson and RMM-DIIS algorithms on chemical systems of up to 1100 atoms. In these tests, the total time is reduced by a factor between 3 and 8 when running on n (CPU core + GPU) compared to n CPU cores only, without any accuracy loss. © 2012 Wiley Periodicals, Inc.

  7. Operations for Learning with Graphical Models

    Buntine, Wray L.

    1994-01-01

    This paper is a multidisciplinary review of empirical, statistical learning from a graphical model perspective. Well-known examples of graphical models include Bayesian net- works, directed graphs representing a Markov chain, and undirected networks representing a Markov field. These graphical models are extended to model data analysis and empirical learning using the notation of plates. Graphical operations for simplifying and manipulating a problem are provided including decomposition, differentiation, and the manipulation of probability models from the exponential family. These operations adapt existing techniques from statistics and automatic differentiation to graphs. Two standard algorithm schemes for learning are reviewed in a graphical framework: Gibbs sampling and the expectation maximization algorithm. Some algorithms are developed in this graphical framework including a generalized version of linear regression, techniques for feed-forward networks, and learning Gaussian and discrete Bayesian networks from data. The paper concludes by sketching some implications for data analysis and summarizing some popular algorithms that fall within the framework presented. The main original contributions here are the decomposition techniques and the demonstration that graphical models provide a framework for understanding and developing complex learning algorithms.

  8. A space systems perspective of graphics simulation integration

    Brown, R.; Gott, C.; Sabionski, G.; Bochsler, D.

    1987-01-01

    Creation of an interactive display environment can expose issues in system design and operation not apparent from nongraphics development approaches. Large amounts of information can be presented in a short period of time. Processes can be simulated and observed before committing resources. In addition, changes in the economics of computing have enabled broader graphics usage beyond traditional engineering and design into integrated telerobotics and Artificial Intelligence (AI) applications. The highly integrated nature of space operations often tend to rely upon visually intensive man-machine communication to ensure success. Graphics simulation activities at the Mission Planning and Analysis Division (MPAD) of NASA's Johnson Space Center are focusing on the evaluation of a wide variety of graphical analysis within the context of present and future space operations. Several telerobotics and AI applications studies utilizing graphical simulation are described. The presentation includes portions of videotape illustrating technology developments involving: (1) coordinated manned maneuvering unit and remote manipulator system operations, (2) a helmet mounted display system, and (3) an automated rendezous application utilizing expert system and voice input/output technology.

  9. Personalized Multilayer Daily Life Profiling Through Context Enabled Activity Classification and Motion Reconstruction: An Integrated System Approach.

    Xu, James Y; Wang, Yan; Barrett, Mick; Dobkin, Bruce; Pottie, Greg J; Kaiser, William J

    2016-01-01

    Profiling the daily activity of a physically disabled person in the community would enable healthcare professionals to monitor the type, quantity, and quality of their patients' compliance with recommendations for exercise, fitness, and practice of skilled movements, as well as enable feedback about performance in real-world situations. Based on our early research in in-community activity profiling, we present in this paper an end-to-end system capable of reporting a patient's daily activity at multiple levels of granularity: 1) at the highest level, information on the location categories a patient is able to visit; 2) within each location category, information on the activities a patient is able to perform; and 3) at the lowest level, motion trajectory, visualization, and metrics computation of each activity. Our methodology is built upon a physical activity prescription model coupled with MEMS inertial sensors and mobile device kits that can be sent to a patient at home. A novel context-guided activity-monitoring concept with categorical location context is used to achieve enhanced classification accuracy and throughput. The methodology is then seamlessly integrated with motion reconstruction and metrics computation to provide comprehensive layered reporting of a patient's daily life. We also present an implementation of the methodology featuring a novel location context detection algorithm using WiFi augmented GPS and overlays, with motion reconstruction and visualization algorithms for practical in-community deployment. Finally, we use a series of experimental field evaluations to confirm the accuracy of the system. PMID:25546868

  10. Real-time graphics rendering engine

    Bao, Hujun

    2011-01-01

    ""Real-Time Graphics Rendering Engine"" reveals the software architecture of the modern real-time 3D graphics rendering engine and the relevant technologies based on the authors' experience developing this high-performance, real-time system. The relevant knowledge about real-time graphics rendering such as the rendering pipeline, the visual appearance and shading and lighting models are also introduced. This book is intended to offer well-founded guidance for researchers and developers who are interested in building their own rendering engines. Hujun Bao is a professor at the State Key Lab of

  11. Practical Implementation of a Graphics Turing Test

    Borg, Mathias; Johansen, Stine Schmieg; Thomsen, Dennis Lundgaard;

    2012-01-01

    We present a practical implementation of a variation of the Turing Test for realistic computer graphics. The test determines whether virtual representations of objects appear as real as genuine objects. Two experiments were conducted wherein a real object and a similar virtual object is presented...... graphics. Based on the results from these experiments, future versions of the Graphics Turing Test could ease the restrictions currently necessary in order to test object telepresence under more general conditions. Furthermore, the test could be used to determine the minimum requirements to achieve object...

  12. OAP- OFFICE AUTOMATION PILOT GRAPHICS DATABASE SYSTEM

    Ackerson, T.

    1994-01-01

    The Office Automation Pilot (OAP) Graphics Database system offers the IBM PC user assistance in producing a wide variety of graphs and charts. OAP uses a convenient database system, called a chartbase, for creating and maintaining data associated with the charts, and twelve different graphics packages are available to the OAP user. Each of the graphics capabilities is accessed in a similar manner. The user chooses creation, revision, or chartbase/slide show maintenance options from an initial menu. The user may then enter or modify data displayed on a graphic chart. The cursor moves through the chart in a "circular" fashion to facilitate data entries and changes. Various "help" functions and on-screen instructions are available to aid the user. The user data is used to generate the graphics portion of the chart. Completed charts may be displayed in monotone or color, printed, plotted, or stored in the chartbase on the IBM PC. Once completed, the charts may be put in a vector format and plotted for color viewgraphs. The twelve graphics capabilities are divided into three groups: Forms, Structured Charts, and Block Diagrams. There are eight Forms available: 1) Bar/Line Charts, 2) Pie Charts, 3) Milestone Charts, 4) Resources Charts, 5) Earned Value Analysis Charts, 6) Progress/Effort Charts, 7) Travel/Training Charts, and 8) Trend Analysis Charts. There are three Structured Charts available: 1) Bullet Charts, 2) Organization Charts, and 3) Work Breakdown Structure (WBS) Charts. The Block Diagram available is an N x N Chart. Each graphics capability supports a chartbase. The OAP graphics database system provides the IBM PC user with an effective means of managing data which is best interpreted as a graphic display. The OAP graphics database system is written in IBM PASCAL 2.0 and assembler for interactive execution on an IBM PC or XT with at least 384K of memory, and a color graphics adapter and monitor. Printed charts require an Epson, IBM, OKIDATA, or HP Laser

  13. Graphics package, Version 4. User Reference Manual

    This manual provides the technical information that a FORTRAN programmer needs to write graphics computer programs. The purpose of this graphics package is to provide an internally consistent, easy-to-use set of graphic subprograms for making publication style plots and illustrations on a variety of display devices. The descriptions in this chapter give an introduction to simple plotting. The intent has been to present an overview in the hope that, with an idea of what is going on, more general methods will be easier to learn

  14. Mathematical optimization in computer graphics and vision

    Velho, Luiz; Gomes, Jonas; de Figueiredo, Luiz

    2011-01-01

    Mathematical optimization is used in nearly all computer graphics applications, from computer vision to animation. This book teaches readers the core set of techniques that every computer graphics professional should understand in order to envision and expand the boundaries of what is possible in their work. Study of this authoritative reference will help readers develop a very powerful tool- the ability to create and decipher mathematical models that can better realize solutions to even the toughest problems confronting computer graphics community today.*Distills down a vast a

  15. Decomposition of Binary Signed-Graphic Matroids

    Pitsoulis, Leonidas

    2010-01-01

    In this paper we employ Tutte's theory of bridges to derive a decomposition theorem for binary matroids arising from signed graphs. The proposed decomposition differs from previous decomposition results on matroids that have appeared in the literature in the sense that it is not based on $k$-sums, but rather on the operation of deletion of a cocircuit. Specifically, it is shown that certain minors resulting from the deletion of a cocircuit of a binary matroid will be graphic matroids apart from exactly one that will be signed-graphic, if and only if the matroid is signed-graphic.

  16. Sensory evaluation, physicochemical properties and aroma-active profiles in a diverse collection of Chinese bayberry (Myrica rubra) cultivars.

    Cheng, Huan; Chen, Jianle; Chen, Shiguo; Xia, Qile; Liu, Donghong; Ye, Xingqian

    2016-12-01

    The present study aimed to differentiate the flavor (taste and odor) profiles of 11 Chinese bayberry cultivars (Myrica rubra). The physicochemical analysis for taste indicated the bayberry cultivars were quite different in soluble sugars, organic acids, color, total phenolics and anthocyanin contents. Sucrose was the main soluble sugar in bayberry fruit. Principal component analysis (PCA) of physicochemical properties indicated bayberries could be divided into 5 groups, and the Bi qi cultivar contained the highest brix/acid ratio demonstrating the sweetest taste. PCA of aroma-active profile for odor (analyzed by SPME-GC-MS-O) indicated bayberries could be divided into 3 groups: α-pinene ("pine" odor) for group 1 (four cultivars), β-caryophyllene and isocaryophyllene ("woody" odor) for group 2 (six cultivars), and ethyl acetate ("overripe" odor) for group 3 (one cultivar). Our research on the physicochemical and active-aroma of 11 bayberry cultivars will help to select suitable cultivars to increase consumer satisfaction. PMID:27374545

  17. Profiles of exercise motivation, physical activity, exercise habit, and academic performance in Malaysian adolescents: A cluster analysis

    Hairul Anuar Hashim; Freddy Golok; Rosmatunisah Ali

    2011-01-01

    Objectives: This study examined Malaysian adolescents’ profiles of exercise motivation, exercise habit strength, academic performance, and levels of physical activity (PA) using cluster analysis.Methods: The sample (n = 300) consisted of 65.6% males and 34.4% females with a mean age of 13.40 ± 0.49. Statistical analysis was performed using cluster analysis.Results: Cluster analysis revealed three distinct cluster groups. Cluster 1 is characterized by a moderate level of PA, relatively high in...

  18. Pathway activation profiling reveals new insights into Age-related Macular Degeneration and provides avenues for therapeutic interventions

    Makarev, Evgeny; Cantor, Charles; Zhavoronkov, Alex; Buzdin, Anton; Aliper, Alexander; Csoka, Antonei Benjamin

    2014-01-01

    Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE). Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis, but the precise molecular pathway alterations are still poorly understood. Therefore we developed a new software program, “AMD Medicine”, and discovered differential pathway activation profiles in samples of human RPE/choro...

  19. HPLC profiling, antioxidant and in vivo anti-inflammatory activity of the ethanol extract of Syzygium jambos available in Bangladesh

    Hossain, Hemayet; Rahman, Shaikh Emdadur; Akbar, Proity Nayeeb; Khan, Tanzir Ahmed; Rahman, Md Mahfuzur; Jahan, Ismet Ara

    2016-01-01

    Background Syzygium jambos has been used as a traditional medicine for the treatment of inflammatory diseases in Bangladesh. The study investigates the high performance liquid chromatography (HPLC) profiling of phenolic compounds, and evaluates the antioxidant and anti-inflammatory activities of ethanol extract of S. jambos available in Bangladesh. Methods The extract was subjected to HPLC for the identification and quantification of the major bioactive polyphenols present in S. jambos. Antio...

  20. HCl and ClO in activated Arctic air; first retrieved vertical profiles from TELIS submillimetre limb spectra

    A. de Lange

    2012-02-01

    Full Text Available The first profile retrieval results of the Terahertz and submillimeter Limb Sounder (TELIS balloon instrument are presented. The spectra are recorded during a 13-h balloon flight on 24 January 2010 from Kiruna, Sweden. The TELIS instrument was mounted on the MIPAS-B2 gondola and shared this platform with the Michelson Interferometer for Passive Atmospheric Sounding (MIPAS and the mini-Differential Optical Absorption Spectroscopy (mini-DOAS instruments. The flight took place within the Arctic vortex at an altitude of ≈34 km in chlorine activated air, and both active (ClO and inactive chlorine (HCl were measured over an altitude range of respectively ≈16–32 km and ≈10–32 km. In this altitude range, the increase of ClO concentration levels during sunrise has been recorded with a temporal resolution of one minute. During the daytime equilibrium, a maximum ClO level of 2.1 ± 0.3 ppbv has been observed at an altitude of 23.5 km. This equilibrium profile is validated against the ClO profile by the satellite instrument Microwave Limb Sounder (MLS aboard EOS Aura. HCl profiles have been determined from two different isotopes – H35Cl and H37Cl – and are also validated against MLS. The precision of all profiles is well below 0.01 ppbv and the overall accuracy is therefore governed by systematic effects. The total uncertainty of these effects is estimated to be maximal 0.3 ppbv for ClO around its peak value at 23.5 km during the daytime equilibrium, and for HCl it ranges from 0.05 to 0.4 ppbv, depending on altitude. In both cases the main uncertainty stems from a largely unknown non-linear response in the detector.

  1. Assessing Sources of Stress to Aquatic Ecosystems: Using Biomarkers and Bioindicators to Characterize Exodure-Response Profiles of Anthropogenic Activities

    Adams, S.M.

    1999-03-29

    Establishing causal relationships between sources of environmental stressors and aquatic ecosystem health if difficult because of the many biotic and abiotic factors which can influence or modify responses of biological systems to stress, the orders of magnitude involved in extrapolation over both spatial and temporal scales, and compensatory mechanisms such as density-dependent responses that operate in populations. To address the problem of establishing causality between stressors and effects on aquatic systems, a diagnostic approach, based on exposure-response profiles for various anthropogenic activities, was developed to help identify sources of stress responsible for effects on aquatic systems at ecological significant levels of biological organization (individual, population, community). To generate these exposure-effects profiles, biomarkers of exposure were plotted against bioindicators of corresponding effects for several major anthropogenic activities including petrochemical , pulp and paper, domestic sewage, mining operations, land-development activities, and agricultural activities. Biomarkers of exposure to environmental stressors varied depending on the type of anthropogenic activity involved. Bioindicator effects, however, including histopathological lesions, bioenergetic status, individual growth, reproductive impairment, and community-level responses were similar among many of the major anthropogenic activities. This approach is valuable to help identify and diagnose sources of stressors in environments impacted by multiple stressors. By identifying the types and sources of environmental stressors, aquatic ecosystems can be more effectively protected and managed to maintain acceptable levels of environmental quality and ecosystem fitness.

  2. HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes.

    Zaugg, Janine; Eickmeier, Eva; Rueda, Diana C; Hering, Steffen; Hamburger, Matthias

    2011-04-01

    A petroleum ether extract of the traditional Chinese herbal drug Duhuo (roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan), showed significant activity in a functional two-microelectrode voltage clamp assay with Xenopus oocytes which expressed recombinant γ-aminobutyric acid type A (GABA(A)) receptors of the subtype α(1)β(2)γ(2S). HPLC-based activity profiling of the active extract revealed six compounds responsible for the GABA(A) receptor modulating activity. They were identified by microprobe NMR and high resolution mass spectrometry as columbianetin acetate (1), imperatorin (3), cnidilin (4), osthol (5), and columbianedin (6). In concentration-dependent experiments, osthol and cnidilin showed the highest potentiation of the GABA induced chloride current (273.6%±39.4% and 204.5%±33.2%, respectively at 300 μM). Bisabolangelone (2) only showed minor activity at the GABA(A) receptor. The example demonstrates that HPLC-based activity profiling is a simple and efficient method to rapidly identify GABA(A) receptor modulators in a bioactive plant extract. PMID:21147202

  3. Prevalence of human cell material: DNA and RNA profiling of public and private objects and after activity scenarios.

    van den Berge, M; Ozcanhan, G; Zijlstra, S; Lindenbergh, A; Sijen, T

    2016-03-01

    Especially when minute evidentiary traces are analysed, background cell material unrelated to the crime may contribute to detectable levels in the genetic analyses. To gain understanding on the composition of human cell material residing on surfaces contributing to background traces, we performed DNA and mRNA profiling on samplings of various items. Samples were selected by considering events contributing to cell material deposits in exemplary activities (e.g. dragging a person by the trouser ankles), and can be grouped as public objects, private samples, transfer-related samples and washing machine experiments. Results show that high DNA yields do not necessarily relate to an increased number of contributors or to the detection of other cell types than skin. Background cellular material may be found on any type of public or private item. When a major contributor can be deduced in DNA profiles from private items, this can be a different person than the owner of the item. Also when a specific activity is performed and the areas of physical contact are analysed, the "perpetrator" does not necessarily represent the major contributor in the STR profile. Washing machine experiments show that transfer and persistence during laundry is limited for DNA and cell type dependent for RNA. Skin conditions such as the presence of sebum or sweat can promote DNA transfer. Results of this study, which encompasses 549 samples, increase our understanding regarding the prevalence of human cell material in background and activity scenarios. PMID:26736139

  4. X-ray Surface Brightness Profiles of Active Galactic Nuclei in the Extended Groth Strip: Implications for AGN Feedback

    Chatterjee, Suchetana; Jeltema, Tesla; Myers, Adam D; Aird, James; Coil, Alison L; Cooper, Michael; Finoguenov, Alexis; Laird, Elise; Montero-Dorta, Antonio; Nandra, Kripal; Willmer, Christopher; Yan, Renbin

    2013-01-01

    Using data from the All Wavelength Extended Groth Strip International Survey (AEGIS) we statistically detect the extended X-ray emission in the interstellar medium (ISM) in both active and normal galaxies at 0.3 < z < 1.3 at a scale of 40-60 kpc. We study the effect of feedback from active galactic nuclei (AGN) on the diffuse interstellar gas by comparing the stacked X-ray surface brightness profiles of active and normal galaxies in the same redshift range with identical properties in optical color--magnitude space. In accordance with theoretical studies we detect a slight deficit (< 1.5 \\sigma) of X-ray photons when averaged over a scale of 0-30 kpc in the profile of AGN host galaxies at 0.3 < z < 0.7. The equivalent flux deficit is (1.25 +/- 0.75) X 10^(-19) ergs/s/cm^(-2). When averaged over a scale of 30-60 kpc, beyond the PSF scales of our AGN sources, we observe a (~ 2 \\sigma) photon excess in the profile of the AGN host galaxies with an equivalent flux excess of (1.1 +/- 0.5) X 10^{-19} ...

  5. Learning Undirected Graphical Models with Structure Penalty

    Ding, Shilin

    2011-01-01

    In undirected graphical models, learning the graph structure and learning the functions that relate the predictive variables (features) to the responses given the structure are two topics that have been widely investigated in machine learning and statistics. Learning graphical models in two stages will have problems because graph structure may change after considering the features. The main contribution of this paper is the proposed method that learns the graph structure and functions on the graph at the same time. General graphical models with binary outcomes conditioned on predictive variables are proved to be equivalent to multivariate Bernoulli model. The reparameterization of the potential functions in graphical model by conditional log odds ratios in multivariate Bernoulli model offers advantage in the representation of the conditional independence structure in the model. Additionally, we impose a structure penalty on groups of conditional log odds ratios to learn the graph structure. These groups of fu...

  6. Collaborative Graphic Rendering for Improving Visual Experience

    Wu, Xiaoxin; Pei, Guodong

    Handheld devices such as UMPC, though convenient, bear weakness of size constraint for display. To mitigate such a problem and enhance user experience for owners of small devices, in this paper we design a collaborative rendering platform. When running game graphic applications at a handheld, the generated OpenGL graphic commands are intercepted and then delivered to a device with a larger display. The graphics are rendered and displayed at that device. The performance of the collaborative rendering platform is determined by graphic computing resources and network bandwidth. Analysis and simulation prove that other than providing a better display, the collaborative system can improve game experience also by increasing frame rates. In particular, at a low computing cost, a further collaboration between GPUs of collaborators can improve frame rate by eliminating the negative impact from network delay on applications that require GPU feedback.

  7. Group Design Problems in Engineering Design Graphics.

    Kelley, David

    2001-01-01

    Describes group design techniques used within the engineering design graphics sequence at Western Washington University. Engineering and design philosophies such as concurrent engineering place an emphasis on group collaboration for the solving of design problems. (Author/DDR)

  8. Interactive Graphics: Exemplified with Real Data Applications

    Waqas Ahmed eMalik

    2011-02-01

    Full Text Available Graphics are widely used in modern applied statistics because they are easy to create, convenient to use, and they can present information effectively. Static plots do not allow interacting with graphics. User interaction, on the other hand, is crucial in exploring data. It gives flexibility and control. One can experiment with the data and the displays. One can investigate the data from different perspectives to produce views that are easily interpretable and informative. In this paper, we try to explain interactive graphics and advocate their use as a practical tool. The benefits and strengths of interactive graphics for data exploration and data quality analyses are illustrated systematically with three complex real datasets.

  9. Realtime multi-plot graphics system

    Shipkowski, Michael S.

    1990-01-01

    The increased complexity of test operations and customer requirements at Langley Research Center's National Transonic Facility (NTF) surpassed the capabilities of the initial realtime graphics system. The analysis of existing hardware and software and the enhancements made to develop a new realtime graphics system are described. The result of this effort is a cost effective system, based on hardware already in place, that support high speed, high resolution, generation and display of multiple realtime plots. The enhanced graphics system (EGS) meets the current and foreseeable future realtime graphics requirements of the NTF. While this system was developed to support wind tunnel operations, the overall design and capability of the system is applicable to other realtime data acquisition systems that have realtime plot requirements.

  10. Helping Students Test Programs That Have Graphical User Interfaces

    Matthew Thornton; Edwards, Stephen H.; Roy Patrick Tan

    2008-01-01

    Within computer science education, many educators are incorporating software testing activities into regular programming assignments. Tools like JUnit and its relatives make software testing tasks much easier, bringing them into the realm of even introductory students. At the same time, many introductory programming courses are now including graphical interfaces as part of student assignments to improve student interest and engagement. Unfortunately, writing software tests for programs that h...

  11. Control interfaces evaluation: Incident tests on graphic displays

    In order to switch successfully from conventional desk interfaces to computer graphics control in the nuclear industry, emphasis is put on matching control systems with operator capabilities. Observation of the diagnosis activity of operators in situations on a simulator helps to draw up design criteria, according to the task characteristics (detection, symptoms, interpretation, location of incidents). Two different sets of images and one desk are used to compare the operators' adaptability. (author). Poster presentation. 8 refs, 6 figs, 2 tabs

  12. Locating Tax Facilities: A Graphics-Based Microcomputer Optimization Model

    Paul D. Domich; Karla L. Hoffman; Richard H. F. Jackson; Marjorie A. McClain

    1991-01-01

    This paper presents a mathematical model that selects locations for Internal Revenue Service Posts-of-Duty. The system is microcomputer-based and uses menus and graphically displayed zip code maps of IRS districts for interactive inputs and solution outputs. The mathematical model used for this problem is the uncapacitated, fixed charge, location-allocation model which minimizes travel and facility costs, given a specified level of activity. A greedy-interchange heuristic is used to obtain "g...

  13. Graphical Models for Security : Second International Workshop

    Kordy, Barbara; Mauw, Sjouke; Jajodia, Sushil

    2016-01-01

    International audience This volume constitutes the thoroughly refereed post-conference proceedings of the Second International Workshop on Graphical Models for Security, GraMSec 2015, held in Verona, Italy, in July 2015.The 5 revised full papers presented together with one short tool paper and one invited article were carefully reviewed and selected from 13 submissions. The GraMSec workshop contributes to the development of well-founded graphical security models, efficient algorithms for t...

  14. Computer graphics in reactor safety analysis

    This paper describes a family of three computer graphics codes designed to assist the analyst in three areas: the modelling of complex three-dimensional finite element models of reactor structures; the interpretation of computational results; and the reporting of the results of numerical simulations. The purpose and key features of each code are presented. The graphics output used in actual safety analysis are used to illustrate the capabilities of each code. 5 refs., 10 figs

  15. Graphical querying of model-driven spreadsheets

    Cunha, Jácome Miguel Costa; Fernandes, João Paulo de Sousa Ferreira; Pereira, Rui Alexandre Afonso; Saraiva, João Alexandre

    2014-01-01

    This paper presents a graphical interface to query modeldriven spreadsheets, based on experience with previous work and empirical studies in querying systems, to simplify query construction for typical end-users with little to no knowledge of SQL. We briefly show our previous text based model-driven querying system. Afterwards, we detail our graphical model-driven querying interface, explaining each part of the interface and showing an example. To validate our work, we executed an empirica...

  16. Interactive Graphics: Exemplified with Real Data Applications

    Waqas Ahmed eMalik; Ali eÜnlü

    2011-01-01

    Graphics are widely used in modern applied statistics because they are easy to create, convenient to use, and they can present information effectively. Static plots do not allow interacting with graphics. User interaction, on the other hand, is crucial in exploring data. It gives flexibility and control. One can experiment with the data and the displays. One can investigate the data from different perspectives to produce views that are easily interpretable and informative. In this paper, we t...

  17. Rough surface scattering simulations using graphics cards

    In this article we present results of rough surface scattering calculations using a graphical processing unit implementation of the Finite Difference in Time Domain algorithm. Numerical results are compared to real measurements and computational performance is compared to computer processor implementation of the same algorithm. As a basis for computations, atomic force microscope measurements of surface morphology are used. It is shown that the graphical processing unit capabilities can be used to speedup presented computationally demanding algorithms without loss of precision.

  18. The pits and falls of graphical presentation

    Sperandei, Sandro

    2014-01-01

    Graphics are powerful tools to communicate research results and to gain information from data. However, researchers should be careful when deciding which data to plot and the type of graphic to use, as well as other details. The consequence of bad decisions in these features varies from making research results unclear to distortions of these results, through the creation of “chartjunk” with useless information. This paper is not another tutorial about “good graphics” and “bad graphics”. Inste...

  19. Quantifying Visual Similarity in Clinical Iconic Graphics

    Starren, Justin B; Payne, Philip R.O.

    2005-01-01

    Numerous studies have demonstrated the benefits of utilizing iconic presentation models in the context of complex medical information. However, very little literature exists that addresses the design of the graphical primitives that constitute such mediums. Utilizing a method named “Presentation Discovery”, the authors of this study examine a manner in which objective techniques may be utilized to prototype such graphical primitives in order to increase the realized expressiveness of ensuing ...

  20. Computer communications and graphics for clinical radiology

    Computer graphics has many forms. When applied in medicine, it can range from simple two dimensional charts and graphs to rendering of three-dimensional scenes. Computer graphic displays of molecular or large anatomic structures have been used to great advantage by numerous medical researchers. In addition, graphic presentations can be dynamic where displays are controlled by physician-user commands, or the presentations can be static, where views are recorded in discrete frames for later distribution or permanent archival. In medicine both interactive and static forms of computer graphics have their proper place in the effective delivery of health care. Computer graphics, however, changes constantly in the area of software techniques, hardware improvements and its clinical application. What may be medically appropriate today in the use of computer graphics can soon become inadequate and well behind the new advances that so quickly follow. In this paper the key feature of computer communication is discussed that aids in the clinical utility of computer graphics in medicine. It is distribution. Distribution in terms of instantaneous computer graphic software updates and more importantly, distribution of meaningful three-dimensional presentations to referring physicians. Physicians who, working in their private offices, have no routine access to medical work stations. In this environment three dimensional presentations of anatomy are static in nature, but must deliver realistic views of critical structures. This paper outlines how computer communication provides the essential ingredient to the provision of this service. As an illustration, the electronic distribution of software to generate three dimensional views of complex anatomoic structures is discussed. Sample views are included

  1. Computation and graphics in mathematical research. Progress report, June 1, 1991--May 31, 1992

    Hoffman, D.A.; Spruck, J.

    1992-08-13

    This report discusses: The description of the GANG Project and results for prior research; the center for geometry, analysis, numerics and graphics; description of GANG Laboratory; software development at GANG; and mathematical and scientific research activities.

  2. Phenolic Profiles and Antioxidant Activity of Litchi (Litchi Chinensis Sonn. Fruit Pericarp from Different Commercially Available Cultivars

    Xiao-Jun Tang

    2012-12-01

    Full Text Available Litchi fruit pericarp (LFP contains significant amounts of phenolics which have been found to exhibit diverse biological activities. The purpose of this work was to determine the varietal differences in phenolic profiles and antioxidant activity of LFP from nine commercially available cultivars. The total phenolic and flavonoid contents ranged from 9.39 to 30.16 mg gallic acid equivalents/g fresh weight (FW and from 7.12 to 23.46 mg catechin equivalents/g FW, respectively. The total anthocyanin contents ranged from 1.77 to 20.94 mg cyanidin-3-glucoside equivalents/100 g FW. Three anthocyanins, including cyanidin-3-rutinoside, cyanidin-3-glucoside, malvidin-3-glucoside, were detected, and cyanidin-3-rutinoside was the predominant constituent which contributes from 68.8% to 100% to total anthocyanins, The total procyanidin contents ranged from 4.35 to 11.82 mg epicatechin equivalents/g FW. Procyanidin B2, epicatechin, A-type procyanidin trimer, and procyanidin A2 were detected in all nine litchi varieties. The oxygen radical absorbance capacity activities and DPPH radical-scavenging activities ranged from 430.49 to 1752.30 μmol TE/100 g FW and from 4.70 to 11.82 mg/g (IC50, respectively. These results indicate that there are significant differences in phytochemical profiles and antioxidant activity among the tested varieties. Knowing the phenolic profiles and antioxidant activity of LFP of different varieties gives the insights into its potential application to promote health.

  3. Solar energy in Italy: a profile of renewable energy activity in its national context

    Shea, C.A.

    1980-12-01

    The following are included: country overview; energy summary; Italian Republic-geopolitical, economic, and cultural aspects; the energy profile; imported energy sources; solar energy research and development; solar energy organizations; solar energy related legislation and administration policies; and international agreements, contacts, manufacturers, and projects. (MHR)

  4. Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants

    Benned-Jensen, Tau; Rosenkilde, M M

    2010-01-01

    In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splice variants and furthe...

  5. Energy in Mexico: a profile of solar energy activity in its national context

    Hawkins, D.

    1980-04-01

    The geopolitical, economic, and cultural aspects of the United States of Mexico are presented. Mexico's energy profile includes the following: energy policy objectives, government energy structure, organizations for implementation, indigeneous energy sources, imported energy sources, solar energy research and development, solar energy organizations and solar energy related legislation and administrative policies. International agreements, contacts, manufacturers, and projects are listed. (MRH)

  6. A Linux Workstation for High Performance Graphics

    Geist, Robert; Westall, James

    2000-01-01

    The primary goal of this effort was to provide a low-cost method of obtaining high-performance 3-D graphics using an industry standard library (OpenGL) on PC class computers. Previously, users interested in doing substantial visualization or graphical manipulation were constrained to using specialized, custom hardware most often found in computers from Silicon Graphics (SGI). We provided an alternative to expensive SGI hardware by taking advantage of third-party, 3-D graphics accelerators that have now become available at very affordable prices. To make use of this hardware our goal was to provide a free, redistributable, and fully-compatible OpenGL work-alike library so that existing bodies of code could simply be recompiled. for PC class machines running a free version of Unix. This should allow substantial cost savings while greatly expanding the population of people with access to a serious graphics development and viewing environment. This should offer a means for NASA to provide a spectrum of graphics performance to its scientists, supplying high-end specialized SGI hardware for high-performance visualization while fulfilling the requirements of medium and lower performance applications with generic, off-the-shelf components and still maintaining compatibility between the two.

  7. Graphical modelling software in R - status

    Dethlefsen, Claus; Højsgaard, Søren; Lauritzen, Steffen L.

    Graphical models in their modern form have been around for nearly a quarter of a century.  Various computer programs for inference in graphical models have been developed over that period. Some examples of free software programs are BUGS (Thomas 1994), CoCo (Badsberg2001), Digram (Klein, Keiding,...... the results of the initiative so far. Specifically we will illustrate some of the R packages for graphical modelling currently on CRAN and discuss their strengths and weaknesses.......Graphical models in their modern form have been around for nearly a quarter of a century.  Various computer programs for inference in graphical models have been developed over that period. Some examples of free software programs are BUGS (Thomas 1994), CoCo (Badsberg2001), Digram (Klein, Keiding......, and Kreiner 1995), MIM (Edwards  2000), and Tetrad (Glymour, Scheines, Spirtes, and Kelley 1987). The gR initiative (Lauritzen 2002) aims at making graphical models available in R (R Development Core Team 2006). A small grant from the Danish Science Foundation supported this initiative. We will summarize...

  8. Income, cumulative risk, and longitudinal profiles of hypothalamic-pituitary-adrenal axis activity in preschool-age children.

    Zalewski, Maureen; Lengua, Liliana J; Thompson, Stephanie F; Kiff, Cara J

    2016-05-01

    Environmental risk predicts disrupted basal cortisol levels in preschool children. However, little is known about the stability or variability of diurnal cortisol morning levels or slope patterns over time in young children. This study used latent profile analysis to identify patterns of the hypothalamic-pituitary-adrenal axis activity during the preschool period. Using a community sample (N = 306), this study measured income, cumulative risk, and children's diurnal cortisol (morning level and slope) four times across 2.5 years, starting when children were 36 months old. Latent profile analysis profiles indicated that there were predominantly stable patterns of diurnal cortisol level and slope over time and that these patterns were predicted by income and cumulative risk. In addition, there were curvilinear relations of income and cumulative risk to profiles of low morning cortisol level and flattened diurnal slope across time, suggesting that both lower and higher levels of income and cumulative risk were associated with a stress-sensitive physiological system. Overall, this study provides initial evidence for the role of environmental risk in predicting lower, flattened basal cortisol patterns that remain stable over time. PMID:26040201

  9. In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae: identification of its main active constituent, structure-activity relationship studies and gene expression profiling

    van Heerden Fanie R

    2011-10-01

    Full Text Available Abstract Background Anti-malarial drug resistance threatens to undermine efforts to eliminate this deadly disease. The resulting omnipresent requirement for drugs with novel modes of action prompted a national consortium initiative to discover new anti-plasmodial agents from South African medicinal plants. One of the plants selected for investigation was Dicoma anomala subsp. gerrardii, based on its ethnomedicinal profile. Methods Standard phytochemical analysis techniques, including solvent-solvent extraction, thin-layer- and column chromatography, were used to isolate the main active constituent of Dicoma anomala subsp. gerrardii. The crystallized pure compound was identified using nuclear magnetic resonance spectroscopy, mass spectrometry and X-ray crystallography. The compound was tested in vitro on Plasmodium falciparum cultures using the parasite lactate dehydrogenase (pLDH assay and was found to have anti-malarial activity. To determine the functional groups responsible for the activity, a small collection of synthetic analogues was generated - the aim being to vary features proposed as likely to be related to the anti-malarial activity and to quantify the effect of the modifications in vitro using the pLDH assay. The effects of the pure compound on the P. falciparum transcriptome were subsequently investigated by treating ring-stage parasites (alongside untreated controls, followed by oligonucleotide microarray- and data analysis. Results The main active constituent was identified as dehydrobrachylaenolide, a eudesmanolide-type sesquiterpene lactone. The compound demonstrated an in vitro IC50 of 1.865 μM against a chloroquine-sensitive strain (D10 of P. falciparum. Synthetic analogues of the compound confirmed an absolute requirement that the α-methylene lactone be present in the eudesmanolide before significant anti-malarial activity was observed. This feature is absent in the artemisinins and suggests a different mode of action

  10. Enhancing graphical literacy skills in the high school science classroom via authentic, intensive data collection and graphical representation exposure

    Palmeri, Anthony

    This research project was developed to provide extensive practice and exposure to data collection and data representation in a high school science classroom. The student population engaged in this study included 40 high school sophomores enrolled in two microbiology classes. Laboratory investigations and activities were deliberately designed to include quantitative data collection that necessitated organization and graphical representation. These activities were embedded into the curriculum and conducted in conjunction with the normal and expected course content, rather than as a separate entity. It was expected that routine practice with graph construction and interpretation would result in improved competency when graphing data and proficiency in analyzing graphs. To objectively test the effectiveness in achieving this goal, a pre-test and post-test that included graph construction, interpretation, interpolation, extrapolation, and analysis was administered. Based on the results of a paired T-Test, graphical literacy was significantly enhanced by extensive practice and exposure to data representation.

  11. Distribution of Metabolically Active Prokaryotes (Archaea and Bacteria) throughout the Profiles of Chernozem and Brown Semidesert Soil

    Semenov, M. V.; Manucharova, N. A.; Stepanov, A. L.

    2016-02-01

    The distribution of metabolically active cells of archaea and bacteria in the profiles of typical chernozems (Voronezh oblast) and brown semidesert soils (Astrakhan oblast) of natural and agricultural ecosystems was studied using the method of fluorescent in situ hybridization (FISH). The studied soils differed sharply in the microbial biomass and in the numbers of metabolically active cells of archaea and bacteria. The number of active bacterial cells was 3.5-7.0 times greater than that of archaea. In the arable chernozem, the numbers of active cells of archaea and bacteria were 2.6 and 1.5 times, respectively, lower than those in the chernozem under the shelterbelt. The agricultural use of the brown semidesert soil had little effect on the abundances of bacteria and archaea. The soil organic carbon content was the major factor controlling the numbers of metabolically active cells of both domains. However, the dependence of the abundance of bacteria on the organic matter content was more pronounced. The decrease in the organic carbon and total nitrogen contents down the soil profiles was accompanied by the decrease in the bacteria: archaea ratio attesting to a better adaptation of archaea to the permanent deficiency of carbon and nitrogen. The bacteria: archaea ratio can serve as an ecotrophic indicator of the state of soil microbial communities.

  12. Increased antioxidant activity and changes in phenolic profile of Kalanchoe pinnata (Lamarck) Persoon (Crassulaceae) specimens grown under supplemental blue light.

    Nascimento, Luana B S; Leal-Costa, Marcos V; Coutinho, Marcela A S; Moreira, Nattacha dos S; Lage, Celso L S; Barbi, Nancy dos S; Costa, Sônia S; Tavares, Eliana S

    2013-01-01

    Antioxidant compounds protect plants against oxidative stress caused by environmental conditions. Different light qualities, such as UV-A radiation and blue light, have shown positive effects on the production of phenols in plants. Kalanchoe pinnata (Lamarck) Persoon (Crassulaceae) is used for treating wounds and inflammations. Some of these beneficial effects are attributed to the antioxidant activity of plant components. We investigated the effects of blue light and UV-A radiation supplementation on the total phenol content, antioxidant activity and chromatographic profile of aqueous extracts from leaves of K. pinnata. Monoclonal plants were grown under white light, white plus blue light and white plus UV-A radiation. Supplemental blue light improved the antioxidant activity and changed the phenolic profile of the extracts. Analysis by HPLC of supplemental blue-light plant extracts revealed a higher proportion of the major flavonoid quercetin 3-O-α-L-arabinopyranosyl (1→2) α-L-rhamnopyranoside, as well as the presence of a wide variety of other phenolic substances. These findings may explain the higher antioxidant activity observed for this extract. Blue light is proposed as a supplemental light source in the cultivation of K. pinnata, to improve its antioxidant activity. PMID:23057576

  13. An interactive graphics information system for familial data.

    Newton, C. M.

    1992-01-01

    GRIFFIN, an interactive graphics system for studying familial information, facilitates viewing of complex databases and introduces graphical representations of multivariate scalar data into a conventional pedigree display format.

  14. Graphic Notation in Music Therapy: A Discussion of What to Notate in Graphic Notation and How

    Bergstrøm-Nielsen, Carl

    2009-01-01

    This article presents graphic notations of music and related forms of communication in music therapy contexts, created by different authors and practitioners. Their purposes, objects of description, and the elements of graphic language are reflected upon in a comparative discussion. From that it...... also important concerns. Among the authors discussed, there is a large variety both in goals and methods. Keywords are proposed to circumscribe moments of possible interest connected to graphic notations. I suggest that the discipline of graphic notation can be useful for the grounding of music therapy...... presentation and research in empirical, clinical musical reality, and welcome further discussion and explorative work....

  15. Effects of solar activity and geomagnetic field on noise in CALIOP profiles above the South Atlantic Anomaly

    V. Noel

    2013-09-01

    Full Text Available By documenting noise levels in 6.5 yr of nighttime measurements by the spaceborne lidar CALIOP above the South Atlantic Anomaly (SAA, we show they contain information about the evolution of upwelling high-energy radiation levels in the area. We find the amount of noisy profiles is influenced by the 11 yr cycle of solar activity, fluctuates by ±5% between 2006 and 2013, and is anticorrelated with solar activity with a 1 yr lag. The size of the SAA grows as solar activity decreases, and an overall westward shift of the SAA region is detectable. We predict SAA noise levels will increase anew after 2014, and will affect future spaceborne lidar missions most near 2020. In other areas, supposedly unaffected by incoming sunlight, nighttime noise levels are much weaker but follow the same 11 yr cycle, superimposed with a one-year cycle that affects both hemispheres similarly and could be attributed to geomagnetic activity.

  16. Sorafenib Has sEH Inhibitory Activity Which Contributes to Its Effect Profile in vivo

    Liu, Jun-Yan; Park, See-Hyoung; Morisseau, Christophe; Hwang, Sung Hee; Hammock, Bruce D.; Robert H. Weiss

    2009-01-01

    The advent of multi-kinase inhibitors targeting the VEGF-receptor has revolutionized the treatment of highly angiogenic malignances such as renal cell carcinoma. Interestingly, several such inhibitors are commercially available, and they each possess diverse specific beneficial and adverse effect profiles. In examining the structure of sorafenib, it was hypothesized that this compound would possess inhibitory effects on the soluble epoxide hydrolase (sEH), an enzyme with pleiotropic effects o...

  17. Secondary Metabolite Profile, Antioxidant Capacity, and Mosquito Repellent Activity of Bixa orellana from Brazilian Amazon Region

    Annamaria Giorgi; Pietro De Marinis; Giuseppe Granelli; Luca Maria Chiesa; Sara Panseri

    2013-01-01

    The Brazilian flora was widely used as source of food and natural remedies to treat various diseases. Bixa orellana L. (Bixaceae), also known as annatto, urucù, or achiote, is a symbol for the Amazonian tribes that traditionally use its seeds as coloured ink to paint their bodies for religious ceremonies. The aim of this study was to investigate the volatile organic compounds (VOCs) profile of B. orellana fresh fruits (in vivo sampled), dried seeds, wood, bark, and leaves analyzed with Headsp...

  18. Flavonoid profile, antioxidant and cytotoxic activity of different extracts from Algerian Rhamnus alaternus L. bark

    Soulef Boussahel; Antonio Speciale; Saliha Dahamna; Yacine Amar; Irene Bonaccorsi; Francesco Cacciola; Francesco Cimino; Paola Donato; Guido Ferlazzo; Daoud Harzallah; Mariateresa Cristani

    2015-01-01

    Background: Rhamnus alaternus (Rhamnaceae) L. has been traditionally used for treatment of many diseases. Objective: In this study, we determined the antioxidant/free radical scavenger properties, the flavonoid profile and the cytotoxicity of aqueous and methanolic extracts obtained by maceration from Algerian R. alaternus bark, like also of aqueous extract prepared by decoction according to the traditional method. This to estimate the usefulness of the drug traditional preparation and compar...

  19. Optimization of HS-GC-FID-MS Method for Residual Solvent Profiling in Active Pharmaceutical Ingredients Using DoE.

    Poceva Panovska, Ana; Acevska, Jelena; Stefkov, Gjoshe; Brezovska, Katerina; Petkovska, Rumenka; Dimitrovska, Aneta

    2016-02-01

    Within this research, a headspace (HS) gas chromatography-flame ionization detector-mass spectrometry method was developed for profiling of residual solvents (RSs) in active pharmaceutical ingredients (APIs). Design of experiment was used for optimization of sample preparation, as well as for robustness testing of the method. HS equilibration temperature and dilution medium were detected as parameters with greater impact on the sensitivity, compared with the time used for equilibration of the samples. Regardless of the sample solubility, the use of water for sample preparation was found to be crucial for better sensitivity. The use of a well-designed strategy for method development and robustness testing, additional level of identification confidence, as well as use of internal standard provided a strong and reliable analytical tool for API fingerprinting, thus enabling the authentication of the substance based on the RS profile. PMID:26290585

  20. Neon and [CII] 158 micron Emission Line Profiles in Dusty Starbursts and Active Galactic Nuclei

    Samsonyan, Anahit; Lebouteiller, Vianney; Barry, Donald; Sargsyan, Lusine

    2016-01-01

    The sample of 379 extragalactic sources is presented that have mid-infrared, high resolution spectroscopy with the Spitzer Infrared Spectrograph (IRS) and also spectroscopy of the [CII] 158 um line with the Herschel Photodetector Array Camera and Spectrometer (PACS). The emission line profiles of [NeII] 12.81 um, [NeIII] 15.55 um, and [CII] 158 um are presented, and intrinsic line widths are determined (full width half maximum of Gaussian profiles after instrumental correction). All line profiles together with overlays comparing positions of PACS and IRS observations are made available in the Cornell Atlas of Spitzer IRS Sources (CASSIS). Sources are classified from AGN to starburst based on equivalent widths of the 6.2 um polycyclic aromatic hydrocarbon feature. It is found that intrinsic line widths do not change among classification for [CII], with median widths of 207 km per s for AGN, 248 km per s for composites, and 233 km per s for starbursts. The [NeII] line widths also do not change with classificati...

  1. Changes in growth, photosynthetic activities, biochemical parameters and amino acid profile of Thompson Seedless grapes (Vitis vinifera L.).

    Somkuwar, R G; Bahetwar, Anita; Khan, I; Satisha, J; Ramteke, S D; Itroutwar, Prerna; Bhongale, Aarti; Oulkar, Dashrath

    2014-11-01

    The study on photosynthetic activity and biochemical parameters in Thompson Seedless grapes grafted on Dog Ridge rootstock and its impact on growth, yield and amino acid profile at various stages of berry development was conducted during the year 2012-2013. Leaf and berry samples from ten year old vines of Thompson Seedless were collected at different growth and berry developmental stages. The analysis showed difference in photosynthetic activity, biochemical parameters and amino acid status with the changes in berry development stage. Higher photosynthetic rate of 17.39 umol cm(-2) s(-1) was recorded during 3-4mm berry size and the lowest (10.08 umol cm(-2) s(-1)) was recorded during the veraison stage. The photosynthetic activity showed gradual decrease with the onset of harvest while the different biochemical parameters showed increase and decrease from one stage to another in both berry and leaves. Changes in photosynthetic activity and biochemical parameters thereby affected the growth, yield and amino acid content of the berry. Positive correlation of leaf area and photosynthetic rate was recorded during the period of study. Reducing sugar (352.25 mg g(-1)) and total carbohydrate (132.52 mg g(-1)) was more in berries as compared to leaf. Amino acid profile showed variations in different stages of berry development. Marked variations in photosynthetic as well as biochemical and amino acid content at various berry development stages was recorded and thereby its cumulative effect on the development of fruit quality. PMID:25522520

  2. Dynamic Resource Access Using Graphical Game in Asymmetric Wireless Networks

    Fangwei Li

    2013-08-01

    Full Text Available In order to improve the resource utilization in asymmetric wireless networks, a novel dynamic resource access algorithm was presented. As the asymmetry of information and the locality of users' actions in distributed wireless networks, the resource access problem was expressed as a simple graphical game model. Let the graphic topology indicate the internal game structure of the realistic environment. Then the Nash equilibrium was got by minimizing the individual regret instead of the system regret. The proposed algorithm realized efficient resource access through exchanging the active information and regret in the competitive community. Theoretical analysis and simulation results show that the algorithm can converge to a suitable pure strategy Nash equilibrium point quickly with less amount of calculation, avoids conflict effectively, and improves the system capacity and power utilization especially in the condition of insufficient resources

  3. Modelling of JET diagnostics using Bayesian Graphical Models

    Svensson, J. [IPP Greifswald, Greifswald (Germany); Ford, O. [Imperial College, London (United Kingdom); McDonald, D.; Hole, M.; Nessi, G. von; Meakins, A.; Brix, M.; Thomsen, H.; Werner, A.; Sirinelli, A.

    2011-07-01

    The mapping between physics parameters (such as densities, currents, flows, temperatures etc) defining the plasma 'state' under a given model and the raw observations of each plasma diagnostic will 1) depend on the particular physics model used, 2) is inherently probabilistic, from uncertainties on both observations and instrumental aspects of the mapping, such as calibrations, instrument functions etc. A flexible and principled way of modelling such interconnected probabilistic systems is through so called Bayesian graphical models. Being an amalgam between graph theory and probability theory, Bayesian graphical models can simulate the complex interconnections between physics models and diagnostic observations from multiple heterogeneous diagnostic systems, making it relatively easy to optimally combine the observations from multiple diagnostics for joint inference on parameters of the underlying physics model, which in itself can be represented as part of the graph. At JET about 10 diagnostic systems have to date been modelled in this way, and has lead to a number of new results, including: the reconstruction of the flux surface topology and q-profiles without any specific equilibrium assumption, using information from a number of different diagnostic systems; profile inversions taking into account the uncertainties in the flux surface positions and a substantial increase in accuracy of JET electron density and temperature profiles, including improved pedestal resolution, through the joint analysis of three diagnostic systems. It is believed that the Bayesian graph approach could potentially be utilised for very large sets of diagnostics, providing a generic data analysis framework for nuclear fusion experiments, that would be able to optimally utilize the information from multiple diagnostics simultaneously, and where the explicit graph representation of the connections to underlying physics models could be used for sophisticated model testing. This

  4. 3-D Graphical Password Used For Authentication

    Vidya Mhaske-Dhamdhere

    2012-03-01

    Full Text Available In today’s world, security isimportant aspect in day to day life.So,everyone used various ways for securitypurpose. People use passwords for theirsecurity.Generally, everyone uses textualpassword. Textual password is combinationof alphabets and numbers. People keeptextual password as name of their favoritethings, actors or actress, dish andmeaningful word from dictionary. But theperson who is very close to that person caneasily guess the password.Graphical password is advancedversion of password. Graphical passwordshave received considerable attention latelyas Potential alternatives to text-basedpasswords.Graphical password is composedof images, parts of images, or sketches[4]-[7]. These passwords are very easy to useand remember. Biometric password is anextended feature of graphical passwords.Biometric password is consisting of facerecognition, thumb impression, eye retinaand heartbeats pulses[10].In this paper, we present andevaluate our contribution, i.e., the 3-Dpassword. The 3-D password is a multifactorauthentication scheme. To be authenticated,we present a 3-D virtual environment wherethe user navigates and interacts with variousobjects. The sequence of actions andinteractions toward the objects inside the 3-D environment constructs the user’s 3-Dpassword. The 3-D password can combinemost existing authentication schemes suchas textual passwords, graphical passwords,and various types of biometrics into a 3-Dvirtual environment. The design of the 3-Dvirtual environment and the type of objectsselected determine the 3-D password keyspace[10].

  5. Graphical calculus for Gaussian pure states

    We provide a unified graphical calculus for all Gaussian pure states, including graph transformation rules for all local and semilocal Gaussian unitary operations, as well as local quadrature measurements. We then use this graphical calculus to analyze continuous-variable (CV) cluster states, the essential resource for one-way quantum computing with CV systems. Current graphical approaches to CV cluster states are only valid in the unphysical limit of infinite squeezing, and the associated graph transformation rules only apply when the initial and final states are of this form. Our formalism applies to all Gaussian pure states and subsumes these rules in a natural way. In addition, the term 'CV graph state' currently has several inequivalent definitions in use. Using this formalism we provide a single unifying definition that encompasses all of them. We provide many examples of how the formalism may be used in the context of CV cluster states: defining the 'closest' CV cluster state to a given Gaussian pure state and quantifying the error in the approximation due to finite squeezing; analyzing the optimality of certain methods of generating CV cluster states; drawing connections between this graphical formalism and bosonic Hamiltonians with Gaussian ground states, including those useful for CV one-way quantum computing; and deriving a graphical measure of bipartite entanglement for certain classes of CV cluster states. We mention other possible applications of this formalism and conclude with a brief note on fault tolerance in CV one-way quantum computing.

  6. Graphic Novels as Great Books: A Grounded Theory Study of Faculty Teaching Graphic Novels

    Evans-Boniecki, Jeannie

    2013-01-01

    This Glaserian grounded theory study, through conceptual coding of interviews and course syllabi, aimed at exploring the motivations and aspirations university professors had when they offered courses dedicated to the study of graphic novels. As a result, the emergence of the graphic novel as a vital literary influence in 21st-century academia was…

  7. Soccer activity profile of altitude versus sea-level natives during acclimatisation to 3600 m (ISA3600)

    Aughey, Robert J; Hammond, Kristal; Varley, Matthew C; Schmidt, Walter F; Bourdon, Pitre C; Buchheit, Martin; Simpson, Ben; Garvican-Lewis, Laura A; Kley, Marlen; Soria, Rudy; Sargent, Charli; Roach, Gregory D; Claros, Jesus C Jimenez; Wachsmuth, Nadine; Gore, Christopher J

    2013-01-01

    Objectives We investigated the effect of high altitude on the match activity profile of elite youth high altitude and sea level residents. Methods Twenty Sea Level (Australian) and 19 Altitude-resident (Bolivian) soccer players played five games, two near sea level (430 m) and three in La Paz (3600 m). Match activity profile was quantified via global positioning system with the peak 5 min period for distance ((D5peak)) and high velocity running (>4.17 m/s, HIVR5peak); as well as the 5 min period immediately subsequent to the peak for both distance (D5sub) and high-velocity running (HIVR5sub) identified using a rolling 5 min epoch. The games at 3600 m were compared with the average of the two near sea-level games. Results The total distance per minute was reduced by a small magnitude in the first match at altitude in both teams, without any change in low-velocity running. There were variable changes in HiVR, D5peak and HiVR5peak from match to match for each team. There were within-team reductions in D5peak in each game at altitude compared with those at near sea level, and this reduction was greater by a small magnitude in Australians than Bolivians in game 4. The effect of altitude on HiVR5peak was moderately lower in Australians compared with Bolivians in game 3. There was no clear difference in the effect of altitude on maximal accelerations between teams. Conclusions High altitude reduces the distance covered by elite youth soccer players during matches. Neither 13 days of acclimatisation nor lifelong residence at high altitude protects against detrimental effects of altitude on match activity profile. PMID:24282196

  8. Graphical User Authentication for E-Transaction

    Dr. Manish Manoria

    2012-10-01

    Full Text Available The most common computer authentication method is to usealphanumerical usernames and passwords. This method has beenshown to have significant drawbacks. A graphical based password isone promising alternatives of textual passwords. According to humanpsychology, humans are able to remember pictures easily. Recently,E-transactions have become an important tool to carry out financialtransactions besides the orthodox banking transactions. They areincreasingly being used to make payments, access bank accounts andfacilitate other commercial transactions. In view of their increasedimportance there is a compelling need to establish ways toauthenticate user during E-transactions. In this paper, we haveproposed a new hybrid graphical password based system, which is acombination of recognition and recall based techniques that offersmany advantages over the orthodox authentication system and maybe more convenient for the user. Our scheme is resistant to Phishingattack and many other attacks on graphical passwords. This scheme isproposed for E-transactions used to make payments and commercialtransactions etc.

  9. Design considerations for parallel graphics libraries

    Crockett, Thomas W.

    1994-01-01

    Applications which run on parallel supercomputers are often characterized by massive datasets. Converting these vast collections of numbers to visual form has proven to be a powerful aid to comprehension. For a variety of reasons, it may be desirable to provide this visual feedback at runtime. One way to accomplish this is to exploit the available parallelism to perform graphics operations in place. In order to do this, we need appropriate parallel rendering algorithms and library interfaces. This paper provides a tutorial introduction to some of the issues which arise in designing parallel graphics libraries and their underlying rendering algorithms. The focus is on polygon rendering for distributed memory message-passing systems. We illustrate our discussion with examples from PGL, a parallel graphics library which has been developed on the Intel family of parallel systems.

  10. Data Sorting Using Graphics Processing Units

    M. J. Mišić

    2012-06-01

    Full Text Available Graphics processing units (GPUs have been increasingly used for general-purpose computation in recent years. The GPU accelerated applications are found in both scientific and commercial domains. Sorting is considered as one of the very important operations in many applications, so its efficient implementation is essential for the overall application performance. This paper represents an effort to analyze and evaluate the implementations of the representative sorting algorithms on the graphics processing units. Three sorting algorithms (Quicksort, Merge sort, and Radix sort were evaluated on the Compute Unified Device Architecture (CUDA platform that is used to execute applications on NVIDIA graphics processing units. Algorithms were tested and evaluated using an automated test environment with input datasets of different characteristics. Finally, the results of this analysis are briefly discussed.

  11. The graphics operator interface to control MAMI

    MAMI (Mainz Microtron), is a c.w. electron accelerator consisting of a cascade of three racetrack microtrons with an output electron beam of 855 MeV and 100 μA, is controlled by a network of computers. A new operator interface using workstations has been developed. This interface enables the operator to control the machine and display graphically the actual status of the accelerator components and systems. The graphic images were developed using a commercial graphics package. Operator actions are performed in the usual way by sending messages to the processes controlling the devices and status display is provided by using the alert feature of the MAMI run-time database. The global status of systems consisting of several components, is computed by a program generated from a logical dependency description in symbolic notation, via a C-code generator. ((orig.))

  12. Graphical Model Theory for Wireless Sensor Networks

    Information processing in sensor networks, with many small processors, demands a theory of computation that allows the minimization of processing effort, and the distribution of this effort throughout the network. Graphical model theory provides a probabilistic theory of computation that explicitly addresses complexity and decentralization for optimizing network computation. The junction tree algorithm, for decentralized inference on graphical probability models, can be instantiated in a variety of applications useful for wireless sensor networks, including: sensor validation and fusion; data compression and channel coding; expert systems, with decentralized data structures, and efficient local queries; pattern classification, and machine learning. Graphical models for these applications are sketched, and a model of dynamic sensor validation and fusion is presented in more depth, to illustrate the junction tree algorithm

  13. Graphical Model Theory for Wireless Sensor Networks

    Davis, William B.

    2002-12-08

    Information processing in sensor networks, with many small processors, demands a theory of computation that allows the minimization of processing effort, and the distribution of this effort throughout the network. Graphical model theory provides a probabilistic theory of computation that explicitly addresses complexity and decentralization for optimizing network computation. The junction tree algorithm, for decentralized inference on graphical probability models, can be instantiated in a variety of applications useful for wireless sensor networks, including: sensor validation and fusion; data compression and channel coding; expert systems, with decentralized data structures, and efficient local queries; pattern classification, and machine learning. Graphical models for these applications are sketched, and a model of dynamic sensor validation and fusion is presented in more depth, to illustrate the junction tree algorithm.

  14. Application of Probiotic (Bacillus subtilis to Enhance Immunity, Antioxidation, Digestive Enzymes Activity and Hematological Profile of Shaoxing Duck

    Imran Rashid Rajput, Wei Fen Li, Ya Li Li, Lei Jian and Min Qi Wang*

    2013-01-01

    Full Text Available The study was designed to evaluate the effects of probiotics (Bacillus subtilis to enhance immunity, antioxidation, digestive enzymes activity and hematological profile of Shaoxing duck. A population of 200 laying ducks (160 days old was divided into two groups each further divided in five replications. The control (G1 were fed on basal diet and (G2 with B. subtilis 1×108 cfu/kg in addition of basal diet for thirty five days. The results showed that, ducks were treated with probiotics (B. subtilis, their serum IL-2 increased and IL-10 decreased (P<0.05. The concentrations of IgG, IgA and sIgA were observed significantly higher in (G2 as compared to (G1. Treatment group (G2, showed significantly improvement in (SOD, T-AOC and ASAFR activity in serum and liver. However, digestive enzymes amylase and trypsin activity also improved (P<0.05 in (G2. The blood chemistry analysis showed significant decrease in FT3 and no other significant change observed in hematological profile as compared to (G1. In conclusion, application of B. subtilis (1×108 cfu/kg may be beneficial to improve antioxidation response, supportive in innate immunity and digestibility of fowls (Shaoxing duck.

  15. On the line profile changes observed during the X2.2 class flare in the active region NOAA 11158

    The solar active region NOAA 11158 produced a series of flares during its passage through the solar disk. The first major flare (of class X2.2) of the current solar cycle occurred in this active region on 2011 February 15 around 01:50 UT. We have analyzed the Dopplergrams and magnetograms obtained by the Helioseismic and Magnetic Imager (HMI) instrument onboard Solar Dynamics Observatory to examine the photospheric velocity and magnetic field changes associated with this flare. The HMI instrument provides high-quality Doppler and magnetic maps of the solar disk with 0.5″ spatial scale at a cadence of 45 s along with imaging spectroscopy. We have identified five locations of velocity transients in the active region during the flare. These transient velocity signals are located in and around the flare ribbons as observed by Hinode in the Ca II H wavelength and the footpoints of hard X-ray enhancement are in the energy range 12–25 keV from RHESSI. The changes in shape and width of two circular polarization states have been observed at the time of transients in three out of five locations. Forward modeling of the line profiles shows that the change in atmospheric parameters such as magnetic field strength, Doppler velocity and source function could explain the observed changes in the line profiles with respect to the pre-flare condition

  16. The influence of thyroid function and bone turnover on lipoprotein profile in young physically active men with different insulin sensitivity.

    Kęska, A; Lutosławska, G; Czajkowska, A; Tkaczyk, J; Mazurek, K; Tomaszewski, P

    2014-06-01

    Physical activity induces changes in the endocrine system. Previous data indicated that changes in insulin secretion and the tissue response to this hormone are very important for energy metabolism. It is believed that they are accompanied by changes in lipid metabolism, but factors contributing to this process are still disputed. The aim of this study was to assess interactions among insulin sensitivity, thyroid function, a bone turnover marker and serum lipid profile in young physically active men. Eighty-seven physical education students, aged 18-23 years, participated in the study. We measured serum levels of glucose, lipids, insulin, thyroid-stimulating hormone (TSH), osteocalcin and anthropometric parameters. Insulin sensitivity was determined using homeostatic model assessment for insulin resistance (HOMA-IR). The median value of HOMA-IR (1.344) was used to divide the study population into Group A (above the median) and Group B (below the median). Men from both groups did not differ in anthropometric parameters or in daily physical activity. Triglycerides (TG), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels were higher in Group A (P lipid profile at a certain level of insulin sensitivity. PMID:24899778

  17. N'-Alkylaminosulfonyl Analogues of 6-Fluorobenzylideneindolinones with Desirable Physicochemical Profiles and Potent Growth Inhibitory Activities on Hepatocellular Carcinoma.

    Chen, Xiao; Yang, Tianming; Deivasigamani, Amudha; Shanmugam, Muthu K; Hui, Kam-Man; Sethi, Gautam; Go, Mei-Lin

    2015-09-01

    The benzylideneindolinone 6-chloro-3-(3'-trifluoromethylbenzylidene)-1,3-dihydroindol-2-one (4) was reported to exhibit potent and selective growth inhibitory effects on hepatocellular carcinoma (HCC). Corroborative evidence supported multi-receptor tyrosine kinase (RTK) inhibition as a possible mode of action. However, the poor physicochemical properties of 4 limited its furtherance as a lead compound. In this study, the modification of 4 was investigated with the aim of improving its potency and physicochemical profile. The 6-fluorobenzylideneindolinone 3-12 bearing a 3'-N-propylaminosulfonyl substituent was found to be a promising substitute. Compound 3-12 [6-fluoro-3-(3'-N-propylaminosulfonylbenzylidene)-1,3-dihydroindol-2-one] was found to be tenfold more soluble than 4 and to have sub-micromolar growth inhibitory activities on HCC cells. It is apoptogenic and inhibits the phosphorylation of several RTKs in HuH7, of which the inhibition of FGFR4 and HER3 are prominent. Compound 3-12 decreased the tumor load in a physiologically relevant orthotopic HCC xenograft murine model. Structure-activity relationships support pivotal roles for the fluoro and N'-propylaminosulfonyl moieties in enhancing cell-based activity and moderating the physicochemical profile (solubility, permeability) of 3-12. PMID:26214403

  18. Profiling of Concanavalin A-Binding Glycoproteins in Human Hepatic Stellate Cells Activated with Transforming Growth Factor-β1

    Yannan Qin

    2014-11-01

    Full Text Available Glycoproteins play important roles in maintaining normal cell functions depending on their glycosylations. Our previous study indicated that the abundance of glycoproteins recognized by concanavalin A (ConA was increased in human hepatic stellate cells (HSCs following activation by transforming growth factor-β1 (TGF-β1; however, little is known about the ConA-binding glycoproteins (CBGs of HSCs. In this study, we employed a targeted glycoproteomics approach using lectin-magnetic particle conjugate-based liquid chromatography-tandem mass spectrometry to compare CBG profiles between LX-2 HSCs with and without activation by TGF-β1, with the aim of discovering novel CBGs and determining their possible roles in activated HSCs. A total of 54 and 77 proteins were identified in the quiescent and activated LX-2 cells, respectively. Of the proteins identified, 14.3% were glycoproteins and 73.3% were novel potential glycoproteins. Molecules involved in protein processing in the endoplasmic reticulum (e.g., calreticulin and calcium signaling (e.g., 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase β-2 [PLCB2] were specifically identified in activated LX-2 cells. Additionally, PLCB2 expression was upregulated in the cytoplasm of the activated LX-2 cells, as well as in the hepatocytes and sinusoidal cells of liver cirrhosis tissues. In conclusion, the results of this study may aid future investigations to find new molecular mechanisms involved in HSC activation and antifibrotic therapeutic targets.

  19. Evaluation of a community-based participatory physical activity promotion project: effect on cardiovascular disease risk profiles of school employees

    Kobza Cee E

    2010-06-01

    Full Text Available Abstract Background The efficacy of physical activity in improving cardiovascular disease (CVD risk profiles has been well established. However, the effectiveness of health promotion programs implemented at the community level remains controversial. This study evaluated a school-based work-site physical activity program. Methods Using a community-based participatory research model, a work-site wellness intervention was implemented in a rural public school system in Southwestern Oklahoma. During the 2005-2006 school year, 187 participants (mean age 45 years completed a pre intervention screening for CVD risk factors followed by a physical activity promotion program. Post intervention screening was conducted after a 6 month period. During both screening sessions, body composition, blood pressure, lipids, glucose and self-reported physical activity levels were assessed. The focus of the intervention was on promoting physical activity. Opportunities for in school physical activity were created by marking hallways, adding a treadmill in each school, and allowing teachers to use planning periods for physical activity. Results During the post intervention screening, compared to pre intervention levels, participants had lower total, low, and high density lipoprotein-cholesterol (t = 5.9, p Conclusions A successful participatory program was associated with improvements in several CVD risk factors among school employees. Limitations of this study such as seasonal variation in the outcome variables and lack of a control group limit our ability to draw solid conclusions about the effectiveness of the intervention.

  20. Evaluation of antioxidant and antimicrobial activities and phenolic profile for Hyssopus officinalis, Ocimum basilicum and Teucrium chamaedrys.

    Vlase, Laurian; Benedec, Daniela; Hanganu, Daniela; Damian, Grigore; Csillag, Ioan; Sevastre, Bogdan; Mot, Augustin C; Silaghi-Dumitrescu, Radu; Tilea, Ioan

    2014-01-01

    This study was designed to examine the in vitro antioxidant and antimicrobial activities and to characterize the polyphenolic composition of the ethanolic extracts of Hyssopus officinalis, Ocimum basilicum and Teucrium chamaedrys. Qualitative and quantitative analysis of the major phenolic compounds were conducted using high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS). The total polyphenols, caffeic acid derivatives and flavonoids content was spectrophotometrically determined. The phenolic profile showed the presence of phenolic acid derivatives (caftaric, gentisic, caffeic, p-coumaric, chlorogenic and ferulic acids), flavonoid glycosides (rutin, isoquercitrin and quercitrin) and free flavonoid aglycons (luteolin, quercetin), in different concentrations. DPPH radical scavenging assay, Trolox equivalent antioxidant capacity (TEAC) method, hemoglobin ascorbate peroxidase activity inhibition (HAPX) assay, and electron paramagnetic resonance (EPR) radicals detection were employed, revealing several aspects of the antioxidant activities of these species. The antimicrobial tests were performed using the disk diffusion assay. These extracts contained a large amount of the polyphenolic compounds (77.72, 175.57, and 243.65 mg/g, respectively), and they showed a good antioxidant activity, as witnessed by a number of methods. T. chamaedrys had a high antimicrobial activity. Besides their antioxidant activity, the antimicrobial effect of these extracts confirms the biological activities of these herbal medicinal products. PMID:24786688

  1. Evaluation of Antioxidant and Antimicrobial Activities and Phenolic Profile for Hyssopus officinalis, Ocimum basilicum and Teucrium chamaedrys

    Laurian Vlase

    2014-04-01

    Full Text Available This study was designed to examine the in vitro antioxidant and antimicrobial activities and to characterize the polyphenolic composition of the ethanolic extracts of Hyssopus officinalis, Ocimum basilicum and Teucrium chamaedrys. Qualitative and quantitative analysis of the major phenolic compounds were conducted using high-performance liquid chromatography coupled to mass spectrometry (HPLC-MS. The total polyphenols, caffeic acid derivatives and flavonoids content was spectrophotometrically determined. The phenolic profile showed the presence of phenolic acid derivatives (caftaric, gentisic, caffeic, p-coumaric, chlorogenic and ferulic acids, flavonoid glycosides (rutin, isoquercitrin and quercitrin and free flavonoid aglycons (luteolin, quercetin, in different concentrations. DPPH radical scavenging assay, Trolox equivalent antioxidant capacity (TEAC method, hemoglobin ascorbate peroxidase activity inhibition (HAPX assay, and electron paramagnetic resonance (EPR radicals detection were employed, revealing several aspects of the antioxidant activities of these species. The antimicrobial tests were performed using the disk diffusion assay. These extracts contained a large amount of the polyphenolic compounds (77.72, 175.57, and 243.65 mg/g, respectively, and they showed a good antioxidant activity, as witnessed by a number of methods. T. chamaedrys had a high antimicrobial activity. Besides their antioxidant activity, the antimicrobial effect of these extracts confirms the biological activities of these herbal medicinal products.

  2. Graphics server and action language interpreter greatly simplify the composition of a graphical user interface

    A new control system based on a distributed computing environment is gradually installed at BESSY, a 800 MeV storage ring dedicated to the generation of synchrotron light in the VUV and soft X-ray region. The new operator consoles are large high resolution, bitmap oriented color graphic screens with mouse and keyboard. A new graphical user interface has been developed with a user interface management system. A graphics server encapsulates completely representational aspects, mediates between user interactions and application variables and takes care of a consistent state of graphical and applicational objects. Graphical representations, semantics of user interactions and interpreter instructions are defined in a database written in a simple and comprehensible user interface definition language. (R.P.) 7 refs.; 5 figs

  3. Modern Computer Graphics Technologies Used at Educational Programs and Some Graphical output screens

    N. Suresh Kumar

    2010-06-01

    Full Text Available In This paper a new technique is implemented to teach microprocessor and to clarify the doubts in the subject microprocessor. Although a lecturer has many aids to explain the topic in the class room, but a graphical environment is more power full environment in the present education scenario, which can improve the student level of understanding. The graphical interface develops the concepts of the student graphics concepts and also a student can easily grasp any level of task. The lecturer shows a visual object or animated show to the student to explain the particular topic in the class room. This work includes the framework of graphics programming; students can concentrate on the technical subject. Thus they acquire a method to construct computer graphics programs in many ways and gain knowledge in the concerned technical paper. The project have used for six years, and convinced of the positive effect.

  4. Active core profile and transport modification by application of Ion Bernstein Wave power in PBX-M

    Application of Ion Bernstein Wave Heating (IBWH) into the Princeton Beta Experiment-Modification (PBX-M) tokamak stabilizes sawtooth oscillations and generates peaked density profiles. A transport barrier, spatially correlated with the IBWH power deposition profile, is observed in the core of IBWH assisted neutral beam injection (NBI) discharges. A precursor to the fully developed barrier is seen in the soft x-ray data during edge localized mode (ELM) activity. Sustained IBWH operation is conducive to a regime where the barrier supports large triangledown ne, triangledown Te, triangledown vphi, and triangledown Ti, delimiting the confinement zone. This regime is reminiscent of the H(high)-mode but with a confinement zone moved inwards. The core region has better than H-mode confinement while the peripheral region is L(low)-mode-like. The peaked profile enhanced NBI core deposition and increases nuclear reactivity. An increase in central Ti results from χi reduction (compared to H-mode) and better beam penetration. Bootstrap current fractions of up to 0.32--0.35 locally and 0.28 overall were obtained when an additional NBI burst is applied to this plasma

  5. Cosmological simulations of galaxy clusters with feedback from active galactic nuclei: profiles and scaling relations

    Pike, Simon R; Newton, Richard D A; Thomas, Peter A; Jenkins, Adrian

    2014-01-01

    We present results from a new set of 30 cosmological simulations of galaxy clusters, including the effects of radiative cooling, star formation, supernova feedback, black hole growth and AGN feedback. We first demonstrate that our AGN model is capable of reproducing the observed cluster pressure profile at redshift, z~0, once the AGN heating temperature of the targeted particles is made to scale with the final virial temperature of the halo. This allows the ejected gas to reach larger radii in higher-mass clusters than would be possible had a fixed heating temperature been used. Such a model also successfully reduces the star formation rate in brightest cluster galaxies and broadly reproduces a number of other observational properties at low redshift, including baryon, gas and star fractions; entropy profiles outside the core; and the X-ray luminosity-mass relation. Our results are consistent with the notion that the excess entropy is generated via selective removal of the densest material through radiative c...

  6. Metabolic profiling of the protozoan parasite Entamoeba invadens revealed activation of unpredicted pathway during encystation.

    Ghulam Jeelani

    Full Text Available Encystation, which is cellular differentiation from the motile, proliferative, labile trophozoite form to the dormant, resistant cyst form, is a crucial process found in parasitic and free-living protozoa such as Entamoeba, Giardia, Acanthamoeba, and Balamuthia. Since encystation is an essential process to deal with the adverse external environmental changes during the life cycle, and often integral to the transmission of the diseases, biochemical understanding of the process potentially provides useful measures against the infections caused by this group of protozoa. In this study, we investigated metabolic and transcriptomic changes that occur during encystation in Entamoeba invadens, the reptilian sibling of mammal-infecting E. histolytica, using capillary electrophoresis-tandem mass spectrometry-based metabolite profiling and DNA microarray-based expression profiling. As the encystation progressed, the levels of majority of metabolites involved in glycolysis and nucleotides drastically decreased, indicating energy generation is ceased. Furthermore, the flux of glycolysis was redirected toward chitin wall biosynthesis. We found remarkable temporal increases in biogenic amines such as isoamylamine, isobutylamine, and cadaverine, during the early period of encystation, when the trophozoites form large multicellular aggregates (precyst. We also found remarkable induction of γ-aminobutyric acid (GABA during encystation. This study has unveiled for the first time the dynamics of the transcriptional and metabolic regulatory networks during encystation, and should help in better understanding of the process in pathogenic eukaryotes, and further development of measures controlling infections they cause.

  7. Clustering Finnish Gambler Profiles Based on the Money and Time Consumed in Gambling Activities.

    Heiskanen, Maria; Toikka, Arho

    2016-06-01

    Gambling involves consumption of gamblers' money and time. Gamblers are a heterogeneous group, and in addition to grouping gamblers based on personality factors, it is also important to find different gambler profiles with respect to their gambling behavior. Using the nationally representative survey 'Finnish Gambling 2011' (N = 4484), this article studies the subtypes of Finnish gamblers based on the frequency of gambling and the amounts of money and time used in different gambling forms. Cluster analysis reveals six profiles of gamblers, from infrequent gamblers to omnivorous gamblers. In the further analysis of the clusters, it was found that the highest problem gambling prevalence was in the groups of sport betting + electronic gaming machine gamblers and omnivorous gamblers, which were also both dominated by men. Certain gambling consumption patterns and risk factors for problem gambling are related to both socio-demographic backgrounds of the gamblers as well as the structural and situational characteristics of the games. The results have implications for the prevention of problem gambling, as some consumption patterns may be connected with the probability of developing gambling problems. PMID:26026988

  8. Engineering Design Graphics: Into the 21st Century

    Harris, La Verne Abe; Meyers, Frederick

    2007-01-01

    Graphical plans for construction of machinery and architecture have evolved over the last 6,000 years beginning from hieroglyphics to drawings on printable media, from the "Golden Age" of engineering graphics to the innovation of computer graphics and prototyping. The evolution of engineering design graphics as a profession has also evolved. Years…

  9. 12th International Conference on Computer Graphics Theory and Applications

    2017-01-01

    The International Conference on Computer Graphics Theory and Applications aims at becoming a major point of contact between researchers, engineers and practitioners in Computer Graphics. The conference will be structured along five main tracks, covering different aspects related to Computer Graphics, from Modelling to Rendering, including Animation, Interactive Environments and Social Agents In Computer Graphics.

  10. Contributions to the integrated graphical user interface

    The Online Software is part of the distributed Data Acquisition System (DAQ) for the ATLAS experiment that will start taking data in 2007 at the Large Hadron Collider at CERN. The Online Software system is responsible for overall experiment control, including run control, configuration and monitoring of Trigger and Data Acquisition System (TDAQ) and management of data-taking partitions. The system encompasses all the software dealing with configuring, controlling and monitoring the data acquisition system but excludes anything dealing with the management, processing or transportation of physics data. In other words, the Online Software is supposed to act as the 'glue' to a quantity of heterogeneous sub-system, providing not only a uniform control interface, but also the possibility of easily abstracting the specificities of those subsystems in order to provide them with control services. The component model architecture has been adopted for the system, each component being developed as an individual package. All the hardware and software configurations of the data taking partitions are stored in configuration databases. The Process Manager component performs the basic job control of the software components. The Integrated Graphical User Interface (IGUI) is one of the integration components of the Online Software, allowing the operator to control and monitor the status of the current data taking run in terms of its main parameters, detector configuration, trigger rate, buffer occupancy and state of the subsystems. The component has been designed as a Java application, having defined some specialized panels for allowing the user to send the main DAQ commands and displaying messages, state or run specific parameters of the whole system or related to all the other components (Run Control, Run Parameters, DAQ Supervisor, Process Manager, Message Reporting, Monitoring or Data Flow). The design of this component allows the users to develop their own panel to be displayed

  11. Graphical Model Debugger Framework for Embedded Systems

    Zeng, Kebin; Guo, Yu; Angelov, Christo K.

    2010-01-01

    Model Driven Software Development has offered a faster way to design and implement embedded real-time software by moving the design to a model level, and by transforming models to code. However, the testing of embedded systems has remained at the code level. This paper presents a Graphical Model...... Debugger Framework, providing an auxiliary avenue of analysis of system models at runtime by executing generated code and updating models synchronously, which allows embedded developers to focus on the model level. With the model debugger, embedded developers can graphically test their design model and...

  12. Graphics card as a cheap supercomputer

    Přikryl, Jan

    Prague: Institute of Mathematics, Academy of Sciences of the Czech Republic, 2013 - (Chleboun, J.; Segeth, K.; Šístek, J.; Vejchodský, T.), s. 162-167 ISBN 978-80-85823-62-2. [Programy a algoritmy numerické matematiky /16./. Dolní Maxov (CZ), 03.06.2012-08.06.2012] R&D Projects: GA TA ČR TA01030603; GA MŠk(CZ) MEB091015 Keywords : GPU * graphics card * Matlab * Jacket * CUDA Subject RIV: JC - Computer Hardware ; Software http://library.utia.cas.cz/separaty/2013/AS/prikryl-graphics card as a cheap supercomputer.pdf

  13. Graphical Model Debugger Framework for Embedded Systems

    Zeng, Kebin

    2010-01-01

    Model Driven Software Development has offered a faster way to design and implement embedded real-time software by moving the design to a model level, and by transforming models to code. However, the testing of embedded systems has remained at the code level. This paper presents a Graphical Model...... Debugger Framework, providing an auxiliary avenue of analysis of system models at runtime by executing generated code and updating models synchronously, which allows embedded developers to focus on the model level. With the model debugger, embedded developers can graphically test their design model...

  14. A graphics based remote handling control system

    A control and simulation system with an interactive graphic man-machine interface is proposed for the articulated boom in JET. The system shall support 1. the study of boom movements in the planning phase, 2. the training of operators by appropriate simulations, 3. the programming of boom movements, and 4. the on-line control of the boom. A combination of computer graphic display and TV-images is proposed for providing optimum recognition of the actual situation and for echoing to the operator actions. (orig.)

  15. Fast Gridding on Commodity Graphics Hardware

    Sørensen, Thomas Sangild; Schaeffter, Tobias; Noe, Karsten Østergaard;

    2007-01-01

    far most time consuming of the three steps (Table 1). Modern graphics cards (GPUs) can be utilised as a fast parallel processor provided that algorithms are reformulated in a parallel solution. The purpose of this work is to test the hypothesis, that a non-cartesian reconstruction can be efficiently...... implemented on graphics hardware giving a significant speedup compared to CPU based alternatives. We present a novel GPU implementation of the convolution step that overcomes the problems of memory bandwidth that has limited the speed of previous GPU gridding algorithms [2]....

  16. Building probabilistic graphical models with Python

    Karkera, Kiran R

    2014-01-01

    This is a short, practical guide that allows data scientists to understand the concepts of Graphical models and enables them to try them out using small Python code snippets, without being too mathematically complicated. If you are a data scientist who knows about machine learning and want to enhance your knowledge of graphical models, such as Bayes network, in order to use them to solve real-world problems using Python libraries, this book is for you. This book is intended for those who have some Python and machine learning experience, or are exploring the machine learning field.

  17. A Linguagem Motion Graphics nos Videoclipes Brasileiros

    Herom Vargas; Luciano Souza

    2013-01-01

    Com o desenvolvimento das tecnologias digitais de edição, animação e pós-produção, a linguagem motion graphics se configurou como ferramenta criativa nas relações entre som e imagem. Este artigo tem como objetivo identificar e analisar aspectos inovadores da utilização da linguagem motion graphics nos videoclipes de artistas brasileiros, no período de 1990 a 2010. Por meio de categorias de avaliação relacionadas 1) aos softwares de composição visual, 2) à evolução da linguagem do clipe no per...

  18. Testing user experience in tablet game graphics

    Härkönen, Heli

    2015-01-01

    As playing games has grown more popular than ever and the market is oversupplied by different games, it has become increasingly important to stand out in the competition. One way for game companies to do this is to concentrate on offering the players great usability and user experience. The purpose of the thesis is to find out how game graphic artists can enhance the user experience in games and increase the playability with their graphics. One of the fastest growing fields of games is m...

  19. Object-oriented graphics programming in C++

    Stevens, Roger T

    2014-01-01

    Object-Oriented Graphics Programming in C++ provides programmers with the information needed to produce realistic pictures on a PC monitor screen.The book is comprised of 20 chapters that discuss the aspects of graphics programming in C++. The book starts with a short introduction discussing the purpose of the book. It also includes the basic concepts of programming in C++ and the basic hardware requirement. Subsequent chapters cover related topics in C++ programming such as the various display modes; displaying TGA files, and the vector class. The text also tackles subjects on the processing

  20. Graphics key element in exploration systems

    This paper reports that smaller fields and rising production costs have made reliable reservoir characterization more critical than ever. Advances in computer graphics systems, especially the use of 3D imaging software, help geoscientist better understand formations. Visual user interface systems and advanced workstations with 3D graphics capabilities help users better interpret seismic data. The use of visualization techniques with stratigraphic interpretation and data management software allows a geoscientist to experiment with a number of possible scenarios on screen. The following applications represent a small portion of the wide range of systems available to explorationists and geoscientist

  1. The construction of tactile graphics for blind students

    Bruno Zucherato

    2011-06-01

    Full Text Available After 1990's access expansion to education for students with special needs has emerged as a very pertinent issue regarding educational policies. In this scenario, we emphasize the teaching of geography for the visually impaired, blind and low vision students, focusing more specifically on the graphics in teaching geography. The  objective of this paper is to report the experiences obtained from August 2008 to August 2009 by UNESP at Rio Claro extension group entitled "Tactile Cartography and MAPAVOX: An alternative way to construct tactile maps and games". During practices conducted for this paper histograms and pie charts were constructed with active participation of students in the whole process. The methodology used in this article was the qualitative research in education, creating an unparalleled analysis of the results and building reports from practices at special school. The final built tactile charts turned to be an important alternative method for teaching graphics for blind and low vision students, using simple features such as low cost materials and taking into account the concern and understanding of visually impaired students in the construction of tactile graphics. The survey results used as the basis for the article will also serve as the basis for the construction of a guide book for teachers who have students who are blind or have low vision in her classroom.

  2. Evaluation of Antioxidant, Antidiabetic and Anticholinesterase Activities of Smallanthus sonchifolius Landraces and Correlation with Their Phytochemical Profiles.

    Russo, Daniela; Valentão, Patrícia; Andrade, Paula B; Fernandez, Eloy C; Milella, Luigi

    2015-01-01

    The present study aimed to investigate the phytochemical profile of leaf methanol extracts of fourteen Smallanthus sonchifolius (yacon) landraces and their antioxidant, anticholinesterase and antidiabetic activities that could lead to the finding of more effective agents for the treatment and management of Alzheimer's disease and diabetes. For this purpose, antioxidant activity was assessed using different tests: ferric reducing ability power (FRAP), 2,2-diphenyl-1-picryl hydrazyl (DPPH), nitric oxide (˙NO) and superoxide (O2˙-) scavenging and lipid peroxidation inhibition assays. Anticholinesterase activity was investigated by quantifying the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities, whereas antidiabetic activity was investigated by α-amylase and α-glucosidase inhibition tests. To understand the contribution of metabolites, phytochemical screening was also performed by high performance liquid chromatography-diode array detector (HPLC-DAD) system. Among all, methanol extract of PER09, PER04 and ECU44 landraces exhibited the highest relative antioxidant capacity index (RACI). ECU44 was found to be rich in 4,5-di-O-caffeoylquinic acid (CQA) and 3,5-di-O-CQA and displayed a good α-amylase and α-glucosidase inhibition, showing the lowest IC50 values. Flavonoids, instead, seem to be involved in the AChE and BChE inhibition. The results of this study revealed that the bioactive compound content differences could be determinant for the medicinal properties of this plant especially for antioxidant and antidiabetic activities. PMID:26263984

  3. Proteomic and activity profiles of ascorbate-glutathione cycle enzymes in germinating barley embryo

    Bønsager, Birgit Christine; Shahpiri, Azar; Finnie, Christine;

    2010-01-01

    Enzymes involved in redox control are important during seed germination and seedling growth. Ascorbate-glutathione cycle enzymes in barley embryo extracts were monitored both by 2D-gel electrophoresis and activity measurements from 4 to 144 h post imbibition (PI). Strikingly different activity...

  4. Stages of Concern Profiles for Active Learning Strategies of Agricultural Technical School Teachers in Egypt

    Myers, Brian E.; Barrick, R. Kirby; Samy, Mohamed M.

    2012-01-01

    Purpose: The purpose of the study was to assess Egyptian Agricultural Technical School (ATS) teachers' implementation of active learning strategies in their classrooms. Methods: The Stages of Concern Questionnaire was administered to 230 participants in active learning workshops. After eliminating headmasters, supervisors and people no longer…

  5. Cognitive and behavioural strategies for fostering creativity in graphic design education / Hanri Elisabet de la Harpe

    De la Harpe, Hanri Elisabet

    2006-01-01

    This study developed a Methodology for the systematic and strategic fostering of creativity in graphic design education at university level. The thesis identified four social-psychological factors that have an effect on graphic design students' creative ability, namely their level of intrinsic motivation for creative activities; their ability to maintain autonomous, self-regulative behaviour that is conducive to creativity; a healthy self-belief in their creative ability and the ...

  6. Stability and activity profile of alkaline protease produced from bacillus subtilis

    The present study gives an insight into the effect of different activators and inhibitors on the activity and stability of alkaline proteases produced by Bacillus subtilis IH-72. The alkaline protease was strongly activated both by bivalent and monovalent cations such as Mg/sup 2+/, Mn/sup 2+/, Na/sup +/ and K/sup +/. The enzyme activity was considerably enhanced in the presence of fructose, galactose, glucose and mannitol. The enzyme was stabilized up to 10 days by immobilization on activated charcoal and was efficiently stabilized up to 2 months by lyophilization. The enzyme remained stable up to 19 days both at 4 degree C and 30 degree C in the presence of Mn/sup 2+/. However, it exhibited significant stability up to 22 days at 4 degree C and 30 degree C in the presence of fructose, galactose and polyethylene glycol. (author)

  7. Effects of high hydrostatic pressure on genomic expression profiling of porcine parthenogenetic activated and cloned embryos

    Lin, Lin; Luo, Yonglun; Sørensen, Peter;

    2014-01-01

    mechanism underlying the effects of HHP treatment on embryonic development is poorly understood and so was investigated in the present study. Thus, in the present study, we undertook genome-wide gene expression analysis in HHP-treated and untreated oocytes, as well as in 4-cell and blastocyst stage embryos...... derived by PA or HMC. Hierarchical clustering depicted stage-specific genomic expression profiling. At the 4-cell and blastocyst stages, 103 and 163 transcripts were differentially expressed between the HMC and PA embryos, respectively (P < 0.05). These transcripts are predominantly involved in regulating...... cellular differentiation, gene expression and cell-to-cell signalling. We found that 44 transcripts were altered by HHP treatment, with most exhibiting lower expression in HHP-treated oocytes. Genes involved in embryonic development were prominent among the transcripts affected by HHP. Two of these genes...

  8. Control of plasma transport by active tailoring of potential profile along open magnetic fields

    Tatematsu, Y.; Kiwamoto, Y.; Saito, T.; Yoshimura, Y.; Takahashi, T.; Katanuma, I.; Inutake, M.; Tamano, T.

    1995-04-01

    This paper studies modifications of convective heat transport in terms of electric and magnetic forces acting on electrons streaming along open field lines. The heat transport is greatly affected by the potential profile along the field lines. One important mechanism of the transport is associated with the exchange of impingig warm electrons with cold electrons produced near or on the surface of plasma-facing walls such as end plates and divertor plates. A recently developed potential model predicts that the end plate potential deepens associated with reduction of cold electron emission. In the GAMMA 10 tandem mirror a negatively biased mesh placed in front of the end plate has successfully suppressed secondary electron emission and leads to deepening of the end plate potential. In the thermal dike ECRH works to mirror reflect colder electrons back to the plate by increasing their pitch angles. The consequent potential depression enhances reflection of warm electrons reaching the plate.

  9. Control of plasma transport by active tailoring of potential profile along open magnetic fields

    This paper studies modifications of convective heat transport in terms of electric and magnetic forces acting on electrons streaming along open field lines. The heat transport is greatly affected by the potential profile along the field lines. One important mechanism of the transport is associated with the exchange of impinging warm electrons with cold electrons produced near or on the surface of plasma-facing walls such as end plates and divertor plates. A recently developed potential model predicts that the end plate potential deepens associated with reduction of cold electron emission. In the GAMMA 10 tandem mirror a negatively biased mesh placed in front of the end plate has successfully suppressed secondary electron emission and leads to deepening of the end plate potential. In the thermal dike ECRH works to mirror-reflect colder electrons back to the plate by increasing their pitch angles. The consequent potential depression enhances reflection of warm electrons reaching the plate. ((orig.))

  10. Application of graphics editors in primary school education

    Pantović, Dijana

    2011-01-01

    This diploma paper presents the problems of the use of graphic programmes in primary schools. Computer graphics is continuously improving its significance in computer science and it is impossible for a teacher or a pupil to avoid working with graphics in today's world. Information displayed in a graphic way are the most suitable and understandable method of processing information. The first part of the diploma paper explains the term computer graphics, its meaning in everyday life and in ...

  11. Making and using shaders in modern computer graphics

    HUČ, ALEKS

    2012-01-01

    In the area of consumer computer graphic was a major turning point in the development of graphics and it's rendering, when new graphic cards with programmable pipeline emerged. What and how something will be done in a single stage of programmable pipeline is provided with a small program called shader. The aim of the thesis is to present the basics of modern computer graphics and use of shaders in computer graphics. We start by presenting the theoretical basis of shaders and comparing program...

  12. The effect of sauna bathing on lipid profile in young, physically active, male subjects

    Dorota Gryka

    2014-08-01

    Full Text Available Objectives: The aim of the study was to evaluate effects of Finnish sauna bathing on lipid profile in healthy, young men. Material and Methods: Sixteen male subjects (20–23 years were subjected to 10 sauna bathing sessions in a Finnish sauna every 1 or 2 days. The mean sauna temperature was 90±2°C, while humidity was 5–16%. Each session consisted of three 15-minute parts and a 2-minute cool-down between them. The following measurements were taken before and after the sauna sessions: body mass, heart rate, body skinfold thickness. The percentage fat content and then, the lean body mass were calculated. Total cholesterol, triacylglycerols, lipoprotein cholesterol LDL and HDL were measured in blood samples. Results: A statistically significant decrease of total cholesterol and LDL cholesterol was observed during 3 weeks of sauna treatment and in the week afterwards. A significant decline in triacylglycerols was found directly after the 1st and 24 h directly after the 10th sauna session. After the 10th sauna session the level of HDL cholesterol remained slightly increased, but this change was not statistically significant. A decrease in blood plasma volume was found directly after the 1st and the last sauna bathing session due to perspiration. An adaptive increase in blood plasma volume was also found after the series of 10 sauna sessions. Conclusions: Ten complete sauna bathing sessions in a Finnish sauna caused a reduction in total cholesterol and LDL cholesterol fraction levels during the sessions and a gradual return of these levels to the initial level during the 1st and the 2nd week after the experiment. A small, statistically insignificant increase in HDL-C level and a transient decline in triacylglycerols were observed after those sauna sessions. The positive effect of sauna on lipid profile is similar to the effect that can be obtained through a moderate-intensity physical exercise.

  13. The effects of repeated exposure to graphic fear appeals on cigarette packages: A field experiment.

    Dijkstra, Arie; Bos, Colin

    2015-03-01

    Experimental studies on the effects of graphic fear appeals on cigarette packages typically expose smokers in a single session to a fear appeal, although in practice the exposure is always repeated. The present study applied an improved study design with repeated exposure to fear appeals on cigarette packages. In this field-experiment, 118 smokers were assigned to 1 of 2 conditions with either graphic fear appeals or textual warnings on their cigarette packages. During 3 weeks, fear and disgust were assessed 6 times. The intention to quit smoking after 3 weeks and quitting activity during the 3 weeks were the dependent measures. The effects of 3 pretest individual difference moderators were tested: disengagement beliefs, number of cigarettes smoked a day, and readiness to quit. Three weeks of exposure to the graphic fear appeals led to a stronger intention to quit, but only when smokers scored low on disengagement beliefs, or were heavier smokers. In addition, smokers low in disengagement more often reported to have cut down on smoking in the graphic condition. There were no indications of habituation of fear and disgust over the 3 weeks. The effects of graphic fear appeals depended on smokers' characteristics: The moderators may explain the mixed findings in the literature. The lack of habituation may be caused by the renewal of the graphics every few days. The used field-experimental design with natural repeated exposure to graphics is promising. PMID:25621418

  14. Phosphoproteomics Profiling of Tobacco Mature Pollen and Pollen Activated in vitro.

    Fíla, Jan; Radau, Sonja; Matros, Andrea; Hartmann, Anja; Scholz, Uwe; Feciková, Jana; Mock, Hans-Peter; Čapková, Věra; Zahedi, René Peiman; Honys, David

    2016-04-01

    Tobacco mature pollen has extremely desiccated cytoplasm, and is metabolically quiescent. Upon re-hydration it becomes metabolically active and that results in later emergence of rapidly growing pollen tube. These changes in cytoplasm hydration and metabolic activity are accompanied by protein phosphorylation. In this study, we subjected mature pollen, 5-min-activated pollen, and 30-min-activated pollen to TCA/acetone protein extraction, trypsin digestion and phosphopeptide enrichment by titanium dioxide. The enriched fraction was subjected to nLC-MS/MS. We identified 471 phosphopeptides that carried 432 phosphorylation sites, position of which was exactly matched by mass spectrometry. These 471 phosphopeptides were assigned to 301 phosphoproteins, because some proteins carried more phosphorylation sites. Of the 13 functional groups, the majority of proteins were put into these categories: transcription, protein synthesis, protein destination and storage, and signal transduction. Many proteins were of unknown function, reflecting the fact that male gametophyte contains many specific proteins that have not been fully functionally annotated. The quantitative data highlighted the dynamics of protein phosphorylation during pollen activation; the identified phosphopeptides were divided into seven groups based on the regulatory trends. The major group comprised mature pollen-specific phosphopeptides that were dephosphorylated during pollen activation. Several phosphopeptides representing the same phosphoprotein had different regulation, which pinpointed the complexity of protein phosphorylation and its clear functional context. Collectively, we showed the first phosphoproteomics data on activated pollen where the position of phosphorylation sites was clearly demonstrated and regulatory kinetics was resolved. PMID:26792808

  15. Bioactive metabolite profiles and antimicrobial activity of ethanolic extracts from Muntingia calabura L. leaves and stems

    William Patrick Cruiz Buhian; Raquel Orejudos Rubio; Demetrio Lim Valle Jr; Juliana Janet Martin-Puzon

    2016-01-01

    Objective: To determine the bioactive phytochemicals and antimicrobial activity of leaf and stem ethanolic extracts from Muntingia calabura L. (M. calabura). Methods: Dried leaves and stems of M. calabura were extracted with 95%ethanol. The antibacterial and antifungal activities of the extracts were examined using the disc diffusion assay. The minimum inhibitory concentration (MIC) of each extract showing antimicrobial activity was determined. The dried extracts were subjected to phyto-chemical screening to determine the presence of bioactive components. Total phenolic and flavonoid contents were also determined by the Folin-Ciocalteu method and the aluminum chloride method, respectively. Results: Varying degrees of antimicrobial activity were exhibited by the leaf and stem extracts against Pseudomonas aeruginosa (P. aeruginosa), Salmonella typhimurium, Staphylococcus aureus (S. aureus), Bacillus subtilis, and Candida albicans (C. albicans), with minimal activity against Escherichia coli. Based on the MIC, the extracts showed the highest activity against C. albicans, S. aureus and P. aeruginosa. Phytochemical screening revealed the presence of sterols, flavonoids, alkaloids, saponins, glycosides and tannins in the leaf extract; however, no triterpenes were detected. In the stem extract, triterpenes were detected along with relative amounts of flavonoids, saponins, glycosides and tannins. Alkaloids and sterols were absent in the stem extract. Conclusions: M. calabura leaf and stem ethanol extracts are potential sources of anti-bacterial agents against P. aeruginosa and S. aureus. This study reports for the first time the high degree of antifungal activity of M. calabura ethanolic extract, especially against C. albicans.

  16. Toward Optimized Surface δ-Profiles of Nitrogen-Vacancy Centers Activated by Helium Irradiation in Diamond.

    Fávaro de Oliveira, Felipe; Momenzadeh, S Ali; Antonov, Denis; Scharpf, Jochen; Osterkamp, Christian; Naydenov, Boris; Jelezko, Fedor; Denisenko, Andrej; Wrachtrup, Jörg

    2016-04-13

    The negatively charged nitrogen-vacancy (NV) center in diamond has been shown recently as an excellent sensor for external spins. Nevertheless, their optimum engineering in the near-surface region still requires quantitative knowledge in regard to their activation by vacancy capture during thermal annealing. To this aim, we report on the depth profiles of near-surface helium-induced NV centers (and related helium defects) by step-etching with nanometer resolution. This provides insights into the efficiency of vacancy diffusion and recombination paths concurrent to the formation of NV centers. It was found that the range of efficient formation of NV centers is limited only to approximately 10 to 15 nm (radius) around the initial ion track of irradiating helium atoms. Using this information we demonstrate the fabrication of nanometric-thin (δ) profiles of NV centers for sensing external spins at the diamond surface based on a three-step approach, which comprises (i) nitrogen-doped epitaxial CVD diamond overgrowth, (ii) activation of NV centers by low-energy helium irradiation and thermal annealing, and (iii) controlled layer thinning by low-damage plasma etching. Spin coherence times (Hahn echo) ranging up to 50 μs are demonstrated at depths of less than 5 nm in material with 1.1% of (13)C (depth estimated by spin relaxation (T1) measurements). At the end, the limits of the helium irradiation technique at high ion fluences are also experimentally investigated. PMID:26938259

  17. Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C

    Griffithsin (GRFT) is possibly the most potent anti-HIV peptide found in natural sources. Due to its potent and broad-spectrum antiviral activity and unique safety profile it has great potential as topical microbicide component. Here, we evaluated various combinations of GRFT against HIV-1 clade B and clade C isolates in primary peripheral blood mononuclear cells (PBMCs) and in CD4+ MT-4 cells. In all combinations tested, GRFT showed synergistic activity profile with tenofovir, maraviroc and enfuvirtide based on the median effect principle with combination indices (CI) varying between 0.34 and 0.79 at the calculated EC95 level. Furthermore, the different glycosylation patterns on the viral envelope of clade B and clade C gp120 had no observable effect on the synergistic interactions. Overall, we can conclude that the evaluated two-drug combination increases their antiviral potency and supports further clinical investigations in pre-exposure prophylaxis for GRFT combinations in the context of HIV-1 clade C infection.

  18. Toward Optimized Surface δ-Profiles of Nitrogen-Vacancy Centers Activated by Helium Irradiation in Diamond

    Fávaro de Oliveira, Felipe; Momenzadeh, S. Ali; Antonov, Denis; Scharpf, Jochen; Osterkamp, Christian; Naydenov, Boris; Jelezko, Fedor; Denisenko, Andrej; Wrachtrup, Jörg

    2016-04-01

    The negatively-charged nitrogen-vacancy (NV) center in diamond has been shown recently as an excellent sensor for external spins. Nevertheless, their optimum engineering in the near-surface region still requires quantitative knowledge in regard to their activation by vacancy capture during thermal annealing. To this aim, we report on the depth profiles of near-surface helium-induced NV centers (and related helium defects) by step-etching with nanometer resolution. This provides insights into the efficiency of vacancy diffusion and recombination paths concurrent to the formation of NV centers. It was found that the range of efficient formation of NV centers is limited only to approximately $10$ to $15\\,$nm (radius) around the initial ion track of irradiating helium atoms. Using this information we demonstrate the fabrication of nanometric-thin ($\\delta$) profiles of NV centers for sensing external spins at the diamond surface based on a three-step approach, which comprises (i) nitrogen-doped epitaxial CVD diamond overgrowth, (ii) activation of NV centers by low-energy helium irradiation and thermal annealing, and (iii) controlled layer thinning by low-damage plasma etching. Spin coherence times (Hahn echo) ranging up to $50\\,$ $\\mu$s are demonstrated at depths of less than $5\\,$nm in material with $1.1\\,\\%$ of $^{13}$C (depth estimated by spin relaxation (T$_1$) measurements). At the end, the limits of the helium irradiation technique at high ion fluences are also experimentally investigated.

  19. Offshore active faults of the Mikata fault zone in Fukui, Japan, revealed by high-resolution seismic profiles

    Inoue, T.; Sugiyama, Y.; Sakamoto, I.; Takino, Y.; Murakami, F.; Hosoya, T.; Usami, T.

    2014-12-01

    The Mikata fault zone are located in coastal and shallow sea area off Fukui Prefecture, West Japan. National Institute of Advanced Industrial Science and Technology (AIST) and Tokai University conducted, as part of MEXT 2013 nearshore active fault survey project, a high-resolution multi-channel seismic survey using Boomer and a 12-channel streamer cable, acoustic profiling survey using parametric sub-bottom profiler and shallow-sea offshore drilling, in order to clarify distribution and activity of the Mikata fault zone. The seismic reflection surveys identified four reflection surfaces as vertical displacement markers in the post-glacial deposits at a depth ranging from ca. 4.5m to ca. 17m below the sea bottom on the downthrown side. We estimated the age of each marker reflection surface by using the C14 age and others from 4m-long core obtained on the downthrown side of fault and the sea level change in the latest Pleistocene and early Holocene around Japan. The results of these surveys have revealed that the fault system was reactivated three times since the latest Pleistocene. The vertical slip rate and average recurrence interval of the fault system are estimated at ca. 0.8-1.0 m/ky and 2,000-3,800 years, respectively.

  20. Effects of gamma irradiation on chickpea seeds vis-a-vis total seed storage proteins, antioxidant activity and protein profiling.

    Bhagyawant, S S; Gupta, N; Shrivastava, N

    2015-01-01

    The present work describes radiation—induced effects on seed composition vis—à—vis total seed proteins, antioxidant levels and protein profiling employing two dimensional gel electrophoresis (2D—GE) in kabuli and desi chickpea varities. Seeds were exposed to the radiation doses of 1,2,3,4 and 5 kGy. The total protein concentrations decreased and antioxidant levels were increased with increasing dose compared to control seed samples. Radiation induced effects were dose dependent to these seed parameters while it showed tolerance to 1 kGy dose. Increase in the dose was complimented with increase in antioxidant levels, like 5 kGy enhanced % scavenging activities in all the seed extracts. Precisely, the investigations reflected that the dose range from 2 to 5 kGy was effective for total seed storage proteins, as depicted quantitatively and qualitative 2D—GE means enhance antioxidant activities in vitro. PMID:26516115