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  1. Nursing Activities Score e demanda de trabalho de enfermagem em terapia intensiva Nursing Activities Score y demanda de trabajo de enfermería em cuidados intensivos Nursing Activities Score and demand of nursing work in intensive care

    Illoma Rossany Lima Leite

    2012-01-01

    Full Text Available OBJETIVO: Medir e caracterizar a carga de trabalho de enfermagem em Unidade de Terapia Intensiva (UTI por meio da aplicação do Nursing Activities Score (NAS. MÉTODOS: Estudo descritivo quantitativo, retrospectivo, realizado em uma das UTIs de um Hospital Filantrópico de Teresina- PI, de setembro a outubro de 2010, com amostra de 66 pacientes. Foram realizadas 285 medidas do escore NAS. RESULTADOS: Quanto à carga de trabalho de enfermagem, foi verificada uma média do escore total do NAS de 68,1% (51,5% e 108,3%, correspondendo à porcentagem de tempo gasto pelo profissional de enfermagem na assistência direta ao paciente nas 24 horas. Houve correlação estatística entre NAS e desfecho clínico (p= 0,001. Já entre NAS e tempo de internação (p= 0,073 e NAS e idade (p=0,952, não houve significância estatística. CONCLUSÃO: Os resultados mostraram que os pacientes apresentaram elevada necessidade de cuidados, refletida pela média elevada do NAS.OBJETIVO: Medir y caracterizar la carga de trabajo de enfermería en una Unidad de Cuidados Intensivos (UCI por medio de la aplicación del Nursing Activities Score (NAS. MÉTODOS: Estudio descriptivo cuantitativo, retrospectivo, realizado en una de las UCIs de un Hospital Filantrópico de Teresina-PI, de setiembre a octubre del 2010, con una muestra de 66 pacientes. Se realizaron 285 medidas del score NAS. RESULTADOS: En cuanto a la carga de trabajo de enfermería, se verificó una media del score total del NAS del 68,1% (51,5% e 108,3%, correspondiendo al porcentaje de tiempo gastado por el profesional de enfermería en la asistencia directa al paciente en las 24 horas. Hubo correlación estadística entre NAS y deshecho clínico (p= 0,001. Ya entre NAS y tiempo de internamiento (p= 0,073 y NAS y edad (p=0,952, no hubo significancia estadística. CONCLUSIÓN: Los resultados mostraron que los pacientes presentaron elevada necesidad de cuidados, reflejada por la elevada media del NAS

  2. Nursing activities score

    Miranda, DR; Nap, R; de Rijk, A; Schaufeli, W; Lapichino, G

    2003-01-01

    Objectives. The instruments used for measuring nursing workload in the intensive care unit (e.g., Therapeutic Intervention Scoring System-28) are based on therapeutic interventions related to severity of illness. Many nursing activities are not necessarily related to severity of illness, and cost-ef

  3. APLICATIVO INFORMATIZADO COM O NURSING ACTIVITIES SCORE: INSTRUMENTO PARA GERENCIAMENTO DA ASSISTÊNCIA EM UNIDADE DE TERAPIA INTENSIVA

    Meire Cristina Novelli e Castro

    2009-01-01

    Full Text Available La gravedad de la enfermedad del paciente o el número de intervenciones no son siempre proporcionales a la carga de trabajo de la enfermería. Este estudio descriptivo tuvo como objetivo demostrar la trayectoria de la construcción de un aplicativo (software con el contenido del Nursing Activities Score y sus características operacionales. Se realizó un test piloto con 12 pacientes y se recolectaron los datos por 90 días consecutivos en 123 pacientes. Hubo compatibilidad en la transmisión de datos del Personal Digital Assistent para la computadora de mesa inalámbrica. La construcción del aplicativo resultó en un sistema con recolección y administración de datos y permitió realizar la interfaz gráfica. La utilización del aplicativo posibilita el uso de un sistema tecnológico para aplicación diaria, con alimentación de un banco de datos sobre las características de los cuidados requeridos. Conociendo la evolución de estas variables durante la hospitalización, el enfermero podrá planificar, intervenir y evaluar la calidad del cuidado.

  4. Sítios assistenciais em Unidade de Terapia Intensiva e relação do nursing activities score com a infecção hospitalar Sitios asistenciales en la Unidad de Terapia Intensiva y la relación de nursing activities score con la infección hospitalaria Assistance sites in the Intensive Care Unit and the relation from nursing activities score with the hospital infection

    Claudia Maria Silva Cyrino

    2012-12-01

    Full Text Available O Sistema de Classificação de Pacientes tornou-se essencial na prática gerencial e assistencial do enfermeiro. Este estudo analisou a implantação de Sítios Assistenciais na Unidade de Terapia Intensiva Adulto como forma de organização e classificação de pacientes, bem como suas implicações na qualidade do cuidado de acordo com o Nursing Activities Score e a relação com a Infecção Hospitalar. Trata-se de um estudo quantitativo, prospectivo, descritivo e transversal. A coleta foi realizada de julho a outubro de 2010. A amostra foi constituída por 214 pacientes, a maioria do sexo masculino, de neurocirurgia e com idade média de 57 anos. O Nursing Activities Score médio foi de 71,72%. Com relação à Infecção Hospitalar antes e após a implantação, houve redução nas taxas de pneumonia, porém, a carga de trabalho de enfermagem permaneceu constante. Ficou evidenciada a importância da utilização do Nursing Activities Score como indicador e da implantação de novas formas de classificação de pacientes para melhorar a organização da assistência.El Sistema de Clasificación de Pacientes se tornó esencial para la práctica gerencial y asistencial del enfermero. Este estudio analizó la implantación de Sitios Asistenciales en la Unidad de Terapia Intensiva Adulta como forma de organización y clasificación de pacientes, bien como sus implicaciones en la calidad del cuidado de acuerdo con el Nursing Activities Score y la relación con Infección Hospitalaria. Se trata del estudio cuantitativo, prospectivo, descriptivo y transversal. La colección de datos fue realizada de julio a octubre de 2010. La muestra fue constituida por 214 pacientes, la mayoría hombres, neurocirúrgicos y con edad media de 57 años. El Nursing Activities Score medio fue 71,72%. Con relación a la Infección Hospitalaria hubo reducción en los niveles de Neumonía, sin embargo, la carga de trabajo de enfermería permaneció constante. Qued

  5. Three New Myrsinol Diterpenes from <em>Euphorbia proliferaem> and Their Neuroprotective Activities

    Yuanqiang Guo

    2012-08-01

    Full Text Available Three new myrsinol diterpenes were isolated from the roots of<em> em>>Euphorbia proliferaem>. Their structures were elucidated as 2<em>α-O>-isobutyryl-3<em>β>,5<em>α>,7<em>β>,10,15<em>β-penta-O>-acetyl-14<em>α-O>-benzoyl-10,18-dihydromyrsinol (1, 2<em>α-O>-isobutyryl-3<em>β-O>-propion-yl-5<em>α>,7<em>β>,10,15<em>β-tetra-O>-acetyl-10,18-dihydromyrsinol (2, and 2<em>α>,14<em>α-di-O>-benzoyl-3<em>β>,5<em>α>,7<em>β>,10,15<em>β-penta-O>-acetyl-10,18-dihydromyrsinol (3 on the basis of spectroscopic data analyses (IR, ESI-MS, HR-ESI-MS, and 1D and 2D NMR. Their neuroprotective activities were evaluated and compounds 1 and 2 showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.

  6. Neonatal Phosphate Nutrition Alters <em>in em>Vivo> and <em>in em>Vitro> Satellite Cell Activity in Pigs

    Chad H. Stahl

    2012-05-01

    Full Text Available Satellite cell activity is necessary for postnatal skeletal muscle growth. Severe phosphate (PO4 deficiency can alter satellite cell activity, however the role of neonatal PO4 nutrition on satellite cell biology remains obscure. Twenty-one piglets (1 day of age, 1.8 ± 0.2 kg BW were pair-fed liquid diets that were either PO4 adequate (0.9% total P, supra-adequate (1.2% total P in PO4 requirement or deficient (0.7% total P in PO4 content for 12 days. Body weight was recorded daily and blood samples collected every 6 days. At day 12, pigs were orally dosed with BrdU and 12 h later, satellite cells were isolated. Satellite cells were also cultured <em>in vitroem> for 7 days to determine if PO4 nutrition alters their ability to proceed through their myogenic lineage. Dietary PO4 deficiency resulted in reduced (<em>P> < 0.05 sera PO4 and parathyroid hormone (PTH concentrations, while supra-adequate dietary PO4 improved (<em>P> < 0.05 feed conversion efficiency as compared to the PO4 adequate group. <em>In vivoem> satellite cell proliferation was reduced (<em>P> < 0.05 among the PO4 deficient pigs, and these cells had altered <em>in vitroem> expression of markers of myogenic progression. Further work to better understand early nutritional programming of satellite cells and the potential benefits of emphasizing early PO4 nutrition for future lean growth potential is warranted.

  7. Study of the <em>in Vitroem> Antiplasmodial, Antileishmanial and Antitrypanosomal Activities of Medicinal Plants from Saudi Arabia

    Nawal M. Al-Musayeib

    2012-09-01

    Full Text Available The present study investigated the <em>in vitroem> antiprotozoal activity of sixteen selected medicinal plants. Plant materials were extracted with methanol and screened <em>in vitroem> against erythrocytic schizonts of <em>Plasmodium falciparumem>, intracellular amastigotes of <em>Leishmania infantum em>and <em>Trypanosoma cruzi em>and free trypomastigotes of<em> T. bruceiem>. Cytotoxic activity was determined against MRC-5 cells to assess selectivity<em>. em>The criterion for activity was an IC50 < 10 µg/mL (4. Antiplasmodial activity was found in the<em> em>extracts of<em> em>>Prosopis julifloraem> and <em>Punica granatumem>. Antileishmanial activity> em>against <em>L. infantumem> was demonstrated in <em>Caralluma sinaicaem> and <em>Periploca aphylla.em> Amastigotes of<em> T. cruzi em>were affected by the methanol extract of<em> em>>Albizia lebbeckem>> em>pericarp, <em>Caralluma sinaicaem>,> Periploca aphylla em>and <em>Prosopius julifloraem>. Activity against<em> T. brucei em>was obtained in<em> em>>Prosopis julifloraem>. Cytotoxicity (MRC-5 IC50 < 10 µg/mL and hence non-specific activities were observed for<em> em>>Conocarpus lancifoliusem>.>

  8. Fumigant Antifungal Activity of Myrtaceae Essential Oils and Constituents from <em>Leptospermum petersoniiem> against Three <em>Aspergillus> Species

    Il-Kwon Park

    2012-09-01

    Full Text Available Commercial plant essential oils obtained from 11 Myrtaceae plant species were tested for their fumigant antifungal activity against <em>Aspergillus ochraceusem>, <em>A. flavusem>, and <em>A. nigerem>. Essential oils extracted from<em> em>Leptospermum> <em>petersonii> at air concentrations of 56 × 10−3 mg/mL and 28 × 10−3 mg/mL completely inhibited the growth of the three <em>Aspergillus> species. However, at an air concentration of 14 × 10−3 mg/mL, inhibition rates of <em>L. petersoniiem> essential oils were reduced to 20.2% and 18.8% in the case of <em>A. flavusem> and <em>A. nigerem>, respectively. The other Myrtaceae essential oils (56 × 10−3 mg/mL only weakly inhibited the fungi or had no detectable affect. Gas chromatography-mass spectrometry analysis identified 16 compounds in <em>L. petersoniiem>> em>essential> em>oil.> em>The antifungal activity of the identified compounds was tested individually by using standard or synthesized compounds. Of these, neral and geranial inhibited growth by 100%, at an air concentration of 56 × 10−3 mg/mL, whereas the activity of citronellol was somewhat lover (80%. The other compounds exhibited only moderate or weak antifungal activity. The antifungal activities of blends of constituents identified in <em>L. petersoniiem> oil indicated that neral and geranial were the major contributors to the fumigant and antifungal activities.

  9. Purification, Characterization and Antioxidant Activities <em>in Vitroem>> em>and <em>in Vivoem> of the Polysaccharides from <em>Boletus edulisem> Bull

    Yijun Fan

    2012-07-01

    Full Text Available A water-soluble polysaccharide (BEBP was extracted from <em>Boletus edulis em>Bull using hot water extraction followed by ethanol precipitation. The polysaccharide BEBP was further purified by chromatography on a DEAE-cellulose column, giving three major polysaccharide fractions termed BEBP-1, BEBP-2 and BEBP-3. In the next experiment, the average molecular weight (Mw, IR and monosaccharide compositional analysis of the three polysaccharide fractions were determined. The evaluation of antioxidant activities both <em>in vitroem> and <em>in vivo em>suggested that BEBP-3 had good potential antioxidant activity, and should be explored as a novel potential antioxidant.

  10. [The NAS system: Nursing Activities Score in mobile technology].

    Catalan, Vanessa Menezes; Silveira, Denise Tolfo; Neutzling, Agnes Ludwig; Martinato, Luísa Helena Machado; Borges, Gilberto Cabral de Mello

    2011-12-01

    The objective of this study was to present the computerized structure that enables the use of the Nursing Activities Score (NAS) in mobile technology. It is a project for the development of technology production based on software engineering, founded on the theory of systems development life cycle. The NAS system was built in two modules: the search module, which is accessed using a personal computer (PC), and Data Collection module, which is accessed through a mobile device (Smartphone). The NAS system was constructed to allow other forms, in addition to the NAS tool, to be included in the future. Thus, it is understood that the development of the NAS will bring nurses closer to mobile technology and facilitate their accessibility to the data of the instrument relating to patients, thus assisting in decision-making and in staffing to provide nursing care. PMID:22241201

  11. Constituents from <em>Vigna em>vexillata> and Their Anti-Inflammatory Activity

    Guo-Feng Chen

    2012-08-01

    Full Text Available The seeds of <em>Vigna em>genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of<em> V. vexillata em>demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of <em>V. vexillataem>. One new sterol (1 and two new isoflavones (2,3 were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23, abscisic acid (25, and quercetin (40 displayed the most significant inhibition of superoxide anion generation and elastase release.

  12. Activity-Guided Isolation of Antioxidant Compounds from <em>Rhizophora apiculataem>

    Hongbin Xiao

    2012-09-01

    Full Text Available <em>Rhizophora apiculataem> (<em>R. apiculataem> contains an abundance of biologically active compounds due its special salt-tolerant living surroundings. In this study, the total phenolic content and antioxidant activities of various extract and fractions of stem of <em>R. apiculataem> were investigated. Results indicated that butanol fraction possesses the highest total phenolic content (181.84 mg/g GAE/g dry extract with strongest antioxidant abilities. Following <em>in vitroem> antioxidant activity-guided phytochemical separation procedures, lyoniresinol-3α-<em>O>-β-arabinopyranoside (1, lyoniresinol-3α-<em>O>-β-rhamnoside (2, and afzelechin-3-<em>O>-L-rhamno-pyranoside (3 were separated from the butanol fraction. These compounds showed more noticeable antioxidant activity than a BHT standard in the DPPH, ABTS and hydroxyl radical scavenging assays. HPLC analysis results showed that among different plant parts, the highest content of 13 was located in the bark (0.068%, 0.066% and 0.011%, respectively. The results imply that the <em>R. apiculataem> might be a potential source of natural antioxidants and 13 are antioxidant ingredients in <em>R. apiculataem>.

  13. Auditory Short-Term Memory Activation during Score Reading

    Simoens, Veerle L; Mari Tervaniemi

    2013-01-01

    Performing music on the basis of reading a score requires reading ahead of what is being played in order to anticipate the necessary actions to produce the notes. Score reading thus not only involves the decoding of a visual score and the comparison to the auditory feedback, but also short-term storage of the musical information due to the delay of the auditory feedback during reading ahead. This study investigates the mechanisms of encoding of musical information in short-term memory during ...

  14. Development and validation of modified disease activity scores in rheumatoid arthritis

    Baker, Joshua F; Conaghan, Philip G; Smolen, Josef S;

    2014-01-01

    (from all time points) with concurrent MRI measures of synovitis and bone edema in the development cohort. Based on regression coefficients, modified versions of the Disease Activity Score in 28 joints (M-DAS28), Simplified Disease Activity Index (M-SDAI), and Clinical Disease Activity Index (M......-CDAI) were generated for each subject in the validation cohort. The M-DAS28, M-SDAI, and M-CDAI scores were compared to conventional scores of disease activity with regard to associations with MRI measures of synovitis and radiographic progression, assessed using Pearson's and Spearman's correlations, linear......'s global assessment of disease activity using a visual analog scale (EvGA score). Modified disease activity scores were generated using the regression coefficients obtained in the synovitis models for all subjects in the validation cohort; modified scores were calculated as M-DAS28 = 0.49 × ln(CRP) + 0...

  15. Antioxidant Activity of Various Parts of <em>Cinnamomum> cassiaem> Extracted with Different Extraction Methods

    Li-Yeh Chuang

    2012-06-01

    Full Text Available The aim of this study was to investigate the antioxidant activities of various parts (barks, buds, and leaves of <em>Cinnamomum cassia em>extracted with ethanol and supercritical fluid extraction (SFE. For the antioxidant activity comparison, IC50 values of the SFE and ethanol extracts in the DPPH scavenging assay were 0.562–10.090 mg/mL and 0.072–0.208 mg/mL, and the Trolox equivalent antioxidant capacity (TEAC values were 6.789–58.335 mmole Trolox/g and 133.039–335.779 mmole Trolox/g, respectively. In addition, the total flavonoid contents were 0.031–1.916 g/ 100 g dry weight of materials (DW and 2.030–3.348 g/ 100 g DW, and the total phenolic contents were 0.151–2.018 g/ 100 g DW and 6.313–9.534 g/ 100 g DW in the SFE and ethanol extracts, respectively. Based on the results, the ethanol extracts of <em>Cinnamon> barks have potential value as an antioxidant substitute and this study also provide a better technique to extract the natural antioxidant substances from <em>C. cassiaem>.

  16. Chemical Composition, Antimicrobial and Antitumor Activities of the Essential Oils and Crude Extracts of<em> Euphorbiaem>> macrorrhizaem>

    Haji Akber Aisa

    2012-05-01

    Full Text Available The present study aimed to examine the chemical composition and biological activity of essential oils extracted from <em>Euphorbia macrorrhizaem> collected from Northwest China. The major constituents of the essential oils of aerial parts and roots of <em>E. macrorrhizaem> are acorenone B (16.72% and 25.80%, (+-cycloisosativene (14.94% and 12.40%, 3a-hydroxy-5b-androstane (10.62% and 5.52%, copaene (7.37% and 6.29%, l-calamenene (4.13% and 4.65% and β-cedrene (8.40% and 7.98%, respectively. The minor components of them are thymene, γ-terpinene, thymecamphor, α-cedrene, zingiberene, trans-caryophyllene, β-chamigrene, curcumene, pentadecane, (−-α-muurolene, cuparene, γ-cadinene, (<em>Z>-3-heptadecene, 1,3,7,7-tetramethyl-2-oxabicyclo(4.4.0dec-5-en-4-one, hexahydrofarnesyl acetone, γ-elixene and palmitinic acid. The antimicrobial and antitumor activitiy of the <em>E. macrorrhizaem> essential oil against <em>Staphyloccocus aureusem>, <em>Escherichia coliem>, <em>Canidia Albicansem> and Caco-2 cells were evaluated. Among all the tested microorganisms and Caco-2 cells, the essential oils showed the strongest inhibitory effect on <em>Staphyloccocus aureus em>(MIC = 2.8 μg/mL and Caco-2 cell (IC50 = 11.86 μg/mL, whereas no effect on <em>Escherichia coliem> and <em>Candida em>albicans>. The data of this study suggested that the <em>E. macrorrhizaem> essential oils have great potential as a natural medicine for microbial infections and cancers.

  17. A disease activity score for ENT involvement in granulomatosis with polyangiitis (Wegener's)

    Del Pero, Marcos Martinez; Chaudhry, Afzal; Rasmussen, Niels;

    2013-01-01

    Accurate assessment of disease activity in patients with otorhinolaryngological manifestations of granulomatosis with polyangiitis (Wegener's) (ENT/GPA) is necessary for treatment decisions and clinical trials. We have designed a disease activity score (ENT/GPA DAS) for this purpose....

  18. Free Radical Scavenging, Antimicrobial and Immunomodulatory Activities of <em>Orthosiphon stamineusem>

    Nabil S. Harmal

    2012-05-01

    Full Text Available <em>Orthosiphon stamineus em>is considered an important traditional folk medicine. In this study ethanol and aqueous extracts of <em>O. stamineusem> were evaluated<em> in vitro em>for their antioxidant, antimicrobial as well as for their immunomodulatory properties on human peripheral blood mononuclear cells (PBMCs. The DPPH radical scavenging method was used for the determination of antioxidant activity, while the antibacterial efficacy was investigated by both disc diffusion method and Minimum Inhibitory Concentration (MIC against four bacterial strains (Gram-positive and Gram-negative. Furthermore, the immunomodulatory potential of the extracts was investigated through the MTT assay. Aqueous extract of <em>O. stamineusem> exhibited significant free radical scavenging activity with IC50 9.6 µg/mL, whereas the IC50 for the ethanol extract was 21.4 µg/mL. The best antimicrobial activity was shown by the aqueous extract of <em>O. stamineus em>against <em>Staphylococcus aureusem>, with inhibition zone of 10.5 mm and MIC value 1.56 mg/mL. Moreover, the results observed from the MTT assay showed that both plant extracts stimulated the PBMCs proliferation<em> in vitroem> in a concentration-dependent manner, but the aqueous extract has remarkable activity against PBMCs. These findings indicate that <em>O. stamineusem> showed high antioxidant activity and may be considered as an immunomodulatory agent.

  19. Butylated Hydroxytoluene Analogs: Synthesis and Evaluation of Their <em>Multipotent em>Antioxidant Activities

    Wageeh A. Yehye

    2012-06-01

    Full Text Available A computer-aided predictions of antioxidant activities were performed with the Prediction Activity Spectra of Substances (PASS program. Antioxidant activity of compounds 1, 3, 4 and 5 were studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH and lipid peroxidation assays to verify the predictions obtained by the PASS program. Compounds 3 and 5 showed more inhibition of DPPH stable free radical at 10−4 M than the well-known standard antioxidant, butylated hydroxytoluene (BHT. Compound 5 exhibited promising <em>in> <em>vitro> inhibition of Fe2+-induced <em>lipid peroxidationem> of the essential egg yolk as a lipid-rich medium<em> em>(83.99%, IC50 16.07 ± 3.51 µM/mL compared to a-tocopherol (a-TOH, 84.6%, IC50 5.6 ± 1.09 µM/mL. The parameters for drug-likeness of these BHT analogues were also evaluated according to the Lipinski’s “rule-of-five” (RO5. All the BHT analogues were found to violate one of the Lipinski’s parameters (Log<em>P> > 5, even though they have been found to be soluble in protic solvents. The predictive polar surface area (PSA and absorption percent (% ABS data allow us to conclude that they could have a good capacity for penetrating cell membranes. Therefore, one can propose these new multipotent antioxidants (MPAOs as potential antioxidants for tackling <em>oxidative stressem> and <em>lipid peroxidation processes.em>> em>

  20. Financial Distress Situation of Listed Malaysian Shipping Companies from 2008 to 2014: Using Altman’s Z- EM Score

    Saravanan Venkadasalam

    2016-05-01

    Full Text Available The main purpose of this paper is to analyse the financial distress situation of Listed Malaysian shipping companies. This paper also analyses the relationship of the company performance with financial distress variables. A secondary data of selected shipping andtransportation service provider’s annual reports from 2008 to 2014 were retrieved from Kuala Lumpur Stock Exchange website. A panel data analysis using Altman’s Z- EM score model and least squares dummy variable (LSDV model were performed. Findings reveal that most of the shipping companies in Malaysia are suffering from the burden of the financial crisis. Ordinary least squares T-tests revealed a significant positive relationship between financial variables and company performance.

  1. Toward Development of a Fibromyalgia Responder Index and Disease Activity Score: OMERACT Module Update

    Mease, Philip J; Clauw, Daniel J; Christensen, Robin;

    2011-01-01

    outcome indices of these domains from archived randomized clinical trials in FM. Possible clinical domains that could be included in a responder index and disease activity score include pain, fatigue, sleep disturbance, cognitive dysfunction, mood disturbance, tenderness, stiffness, and functional...... impairment. Outcome measures for these domains demonstrate good to adequate psychometric properties, although measures of cognitive dysfunction need to be further developed. The approach used in the development of responder indices and disease activity scores for rheumatoid arthritis and ankylosing...

  2. Evaluation of Antioxidant Activities of Aqueous Extracts and Fractionation of Different Parts of <em>Elsholtzia em>ciliata>

    Yuangang Zu

    2012-05-01

    Full Text Available The aim of this study was to investigate the antioxidant and free-radical scavenging activity of extract and fractions from various parts of <em>Elsholtzia ciliataem>. The inflorescences, leaves, stems and roots of <em>E. ciliataem> were extracted separately and two phenolic component enrichment methods: ethyl acetate-water liquid-liquid extraction and macroporous resin adsorption-desorption, were adopted in this study. The antioxidant activities of water extracts and fractions of <em>E. ciliataem> were examined using different assay model systems <em>in vitroem>. The fraction root E (purified by HPD300 macroporous resin exhibited the highest total phenolics content (497.2 ± 24.9 mg GAE/g, accompanied with the highest antioxidant activity against various antioxidant systems <em>in vitroem> compared to other fractions. On the basis of the results obtained, <em>E. ciliataem> extracts can be used potentially as a ready accessible and valuable bioactive source of natural antioxidants.

  3. Platelet-Activating Factor (PAF Antagonistic Activity of a New Biflavonoid from <em>Garcinia nervosaem> var. <em>pubescens> King

    Azura Abdul Ghani

    2012-09-01

    Full Text Available The methanol extract of the leaves of <em>Garcinia nervosaem> var. <em>pubescens> King, which showed strong inhibitory effects on platelet-activating factor (PAF receptor binding, was subjected to bioassay-guided isolation to obtain a new biflavonoid, II-3,I-5, II-5,II-7,I-4',II-4'-hexahydroxy-(I-3,II-8-flavonylflavanonol together with two known flavonoids, 6-methyl-4'-methoxyflavone and acacetin. The structures of the compounds were elucidated by spectroscopic methods. The compounds were evaluated for their ability to inhibit PAF receptor binding to rabbit platelets using 3H-PAF as a ligand. The biflavonoid and acacetin showed strong inhibition with IC50 values of 28.0 and 20.4 µM, respectively. The results suggest that these compounds could be responsible for the strong PAF antagonistic activity of the plant.

  4. Phenolic Compounds and Antioxidant Activity of Bulb Extracts of Six <em>Lilium> Species Native to China

    Lixin Niu

    2012-08-01

    Full Text Available Lily (<em>Lilium> is used as an important edible and medical plant species with a vague taxonomic classification and a long history in China. Bulbs of six <em>Lilium> species (<em>L. regaleem>,> L. concolorem>,> L. pumilumem>,> L. leucanthumem>,> L. davidii var. unicolorem> and <em>L. lancifoliumem> native to China were investigated with a view to their exploitation as a potential source of natural antioxidants due to their phenolic composition and dietary antioxidant potential. The results showed that all bulb extracts exhibited strong antioxidant activities, which generally correlated positively with the total phenolic contents (r = 0.68 to 0.94, total flavonoid contents (r = 0.51 to 0.89 and total flavanol contents (r = 0.54 to 0.95. High-performance liquid chromatography (HPLC analysis revealed that rutin and kaempferol were the major phenolic components in the extracts. Hierarchical cluster analysis showed that <em>L. regaleem> belonged to the group with high phenolic content and strong antioxidant power. <em>L. concolorem> and <em>L. pumilumem> were arranged in one group characterized by moderate phenolic content and antioxidant capacity, while <em>L. leucanthumem>, <em>L. davidii var. unicolorem> and <em>L. lancifoliumem> were clustered in the third group with low phenolic content and weak antioxidant activity. These strongly suggest that lily bulbs may serve as a potential source of natural antioxidant for food and pharmaceutical applications.

  5. <em>In Vitro em>Phytotoxicity and Antioxidant Activity of Selected Flavonoids

    Rita Patrizia Aquino

    2012-05-01

    Full Text Available The knowledge of flavonoids involved in plant-plant interactions and their mechanisms of action are poor and, moreover, the structural characteristics required for these biological activities are scarcely known. The objective of this work was to study the possible <em>in vitro em>phytotoxic effects of 27 flavonoids on the germination and early radical growth of <em>Raphanus sativus em>L.> and <em>Lepidium sativumem> L., with the aim to evaluate the possible structure/activity relationship. Moreover, the antioxidant activity of the same compounds was also evaluated. Generally, in response to various tested flavonoids, germination was only slightly affected, whereas significant differences were observed in the activity of the various tested flavonoids against radical elongation. DPPH test confirms the antioxidant activity of luteolin, quercetin, catechol, morin, and catechin. The biological activity recorded is discussed in relation to the structure of compounds and their capability to interact with cell structures and physiology. No correlation was found between phytotoxic and antioxidant activities.

  6. Why mental arithmetic counts: brain activation during single digit arithmetic predicts high school math scores.

    Price, Gavin R; Mazzocco, Michèle M M; Ansari, Daniel

    2013-01-01

    Do individual differences in the brain mechanisms for arithmetic underlie variability in high school mathematical competence? Using functional magnetic resonance imaging, we correlated brain responses to single digit calculation with standard scores on the Preliminary Scholastic Aptitude Test (PSAT) math subtest in high school seniors. PSAT math scores, while controlling for PSAT Critical Reading scores, correlated positively with calculation activation in the left supramarginal gyrus and bilateral anterior cingulate cortex, brain regions known to be engaged during arithmetic fact retrieval. At the same time, greater activation in the right intraparietal sulcus during calculation, a region established to be involved in numerical quantity processing, was related to lower PSAT math scores. These data reveal that the relative engagement of brain mechanisms associated with procedural versus memory-based calculation of single-digit arithmetic problems is related to high school level mathematical competence, highlighting the fundamental role that mental arithmetic fluency plays in the acquisition of higher-level mathematical competence. PMID:23283330

  7. Molluscicidal Activity of Methomyl and Cardenolide Extracts from <em>Calotropis proceraem> and <em>Adenium> <em>arabicum> Against the Land Snail <em>Monacha cantianaem>

    Alaa Bayoumi

    2012-05-01

    Full Text Available In this work, we have evaluated the molluscicidal activity of two cardenolide extracts from <em>Adenium arabicumem> Balf f. [the benzene (B and methanol (M extracts], one cardenolide extract from <em>Calotropis proceraem> (Aiton W.T. Aiton (extract C, and methomyl against the harmful land snail <em>Monacha cantianaem> (Montagu. The contact LD50 values for the above mentioned plant extracts were 12.62, 34.63, and 34.35 mg·kg−1 of body weight, respectively, while the LD50 for methomyl was 116.62 mg·kg−1, that is, the plant extracts were 9.24, 3.37, and 3.4 times more toxic than methomyl. In addition, a simple colorimetric method, based on Kedde reagent, was modified to determine cardenolide concentrations in plant extracts. Thin layer chromatography analysis (TLC showed several cardiac glycosidal compounds in each plant extract. The results proved that cardiac glycosides are promising candidate compounds that could be used to control land snails, or exploited to develop new, effective, and environmentally friendly molluscicides.

  8. Chemical Composition and Biological Activities of the Essential Oils from <em>Duguetia lanceolataem> St. Hil. Barks

    Maria A. C. Kaplan

    2012-09-01

    Full Text Available Essential oils of <em>Duguetia lanceolataem> barks, obtained at 2 (T2 and 4 h (T4, were identified by gas chromatography and gas chromatography/mass spectrometry. β-Elemene (12.7 and 14.9%, caryophyllene oxide (12.4 and 10.7% and β-selinene (8.4 and 10.4% were the most abundant components in T2 and T4, respectively. The essential oils inhibited the growth of <em>Staphylococcus aureusem>,> Streptococcus pyogenesem>, <em>Escherichia coliem> and <em>Candida albicansem>. The essential oils were cytotoxic against brine shrimp. The extraction time influenced the chemical composition and biological activities of essential oils obtained from the barks of <em>D. lanceolataem>.

  9. Phytochemical Composition, Antioxidant and Xanthine Oxidase Inhibitory Activities of <em>Amaranthus cruentusem> L. and <em>Amaranthus hybridusem> L. Extracts

    Jeanne F. Millogo

    2012-06-01

    Full Text Available This paper describes a preliminary assessment of the nutraceutical value of <em>Amaranthus cruentus (A. cruentusem> and <em>Amaranthus hybridus (A. hybridusem>, two food plant species found in Burkina Faso. Hydroacetonic (HAE, methanolic (ME, and aqueous extracts (AE from the aerial parts were screened for <em>in vitroem> antioxidant and xanthine oxidase inhibitory activities. Phytochemical analyses revealed the presence of polyphenols, tannins, flavonoids, steroids, terpenoids, saponins and betalains. Hydroacetonic extracts have shown the most diversity for secondary metabolites. The TLC analyses of flavonoids from HAE extracts showed the presence of rutin and other unidentified compounds. The phenolic compound contents of the HAE, ME and AE extracts were determined using the Folin–Ciocalteu method and ranged from 7.55 to 10.18 mg Gallic acid equivalent GAE/100 mg. Tannins, flavonoids, and flavonols ranged from 2.83 to 10.17 mg tannic acid equivalent (TAE/100 mg, 0.37 to 7.06 mg quercetin equivalent (QE /100 mg, and 0.09 to 1.31 mg QE/100 mg, respectively. The betacyanin contents were 40.42 and 6.35 mg Amaranthin Equivalent/100 g aerial parts (dry weight in <em>A. cruentusem> and <em>A. hybridusem>, respectively. Free-radical scavenging activity expressed as IC50 (DPPH method and iron reducing power (FRAP method ranged from 56 to 423 µg/mL and from 2.26 to 2.56 mmol AAE/g, respectively. Xanthine oxidase inhibitory activities of extracts of <em>A. cruentus em>and <em>A. hybridusem> were 3.18% and 38.22%, respectively.<em> em>The> A. hybridusem> extract showed the best antioxidant and xanthine oxidase inhibition activities. The results indicated that the phytochemical contents of the two species justify their traditional uses as nutraceutical food plants.

  10. Schizotypal perceptual aberrations of time: correlation between score, behavior and brain activity.

    Shahar Arzy

    Full Text Available A fundamental trait of the human self is its continuum experience of space and time. Perceptual aberrations of this spatial and temporal continuity is a major characteristic of schizophrenia spectrum disturbances--including schizophrenia, schizotypal personality disorder and schizotypy. We have previously found the classical Perceptual Aberration Scale (PAS scores, related to body and space, to be positively correlated with both behavior and temporo-parietal activation in healthy participants performing a task involving self-projection in space. However, not much is known about the relationship between temporal perceptual aberration, behavior and brain activity. To this aim, we composed a temporal Perceptual Aberration Scale (tPAS similar to the traditional PAS. Testing on 170 participants suggested similar performance for PAS and tPAS. We then correlated tPAS and PAS scores to participants' performance and neural activity in a task of self-projection in time. tPAS scores correlated positively with reaction times across task conditions, as did PAS scores. Evoked potential mapping and electrical neuroimaging showed self-projection in time to recruit a network of brain regions at the left anterior temporal cortex, right temporo-parietal junction, and occipito-temporal cortex, and duration of activation in this network positively correlated with tPAS and PAS scores. These data demonstrate that schizotypal perceptual aberrations of both time and space, as reflected by tPAS and PAS scores, are positively correlated with performance and brain activation during self-projection in time in healthy individuals along the schizophrenia spectrum.

  11. Scoring inflammatory activity of the spine by magnetic resonance imaging in ankylosing spondylitis: a multireader experiment

    Lukas, Cédric; Braun, Jürgen; van der Heijde, Désirée;

    2007-01-01

    OBJECTIVE: Magnetic resonance imaging (MRI) of the spine is increasingly important in the assessment of inflammatory activity in clinical trials with patients with ankylosing spondylitis (AS). We investigated feasibility, inter-reader reliability, sensitivity to change, and discriminatory ability...... of 3 different scoring methods for MRI activity and change in activity of the spine in patients with AS. METHODS: Thirty sets of spinal MRI at baseline and after 24 weeks of followup, derived from a randomized clinical trial comparing a tumor necrosis factor (TNF)-blocking drug (n = 20) with placebo...... (n = 10) and selected to cover a wide range of activity at baseline and change in activity, were presented electronically in a partial latin-square design to 9 experienced readers from different countries (Europe, Canada). Readers scored each set of MRI 3 times, using 3 different methods including...

  12. Comparação dos escores dos protocolos QVV, IDV e PPAV em professores Comparison of V-RQOL, VHI and VAPP scores in teachers

    Alessandra Sayuri Tutya

    2011-09-01

    Handicap Index and VAPP (Voice Activity and Participation Profile, and to analyze the correspondence of information obtained by these instruments. METHODS: Fourty six teachers with voice complaints that sought for speech-language pathology intervention and were diagnosed with behavioral dysphonia answered randomly the V-RQOL, VHI and VAPP questionnaires. RESULTS: Dysphonic teachers presented worse quality of life than the general dysphonic population on the V-RQOL. The VHI showed no significant handicap. On the VAPP, teachers had lower scores in the effects in social communication. The physical (VHI and physical functioning (V-RQOL domains were similar to each other. The VAPP provides information about aspects not contemplated by the other protocols; self-perception of the severity of dysphonia was correlated with all domains of the three protocols. The items with greatest impact on the V-RQOL were from the physical functioning domain, and, on the VHI, from the physical domain. On the VAPP, the two questions with greater occurrence were related to the effect of voice over emotion. Hence, for this population, it is suggested the use of the VAPP questionnaire, because it comprises aspects that the others don't; in addition, the V-RQOL should also be used, because it has fewer questions and more impact (total and emotional scores than the VHI. CONCLUSION: The protocols do not show the same information for dysphonic teachers. The physical functioning (V-RQOL and physical (VHI domains provide similar results, however social-emotional domain of the V-RQOL exhibited more evidently the impact of the voice disorder in dysphonic teachers than the VHI. The VAPP present information not contemplated by the other protocols.

  13. Schizotypal Perceptual Aberrations of Time: Correlation between Score, Behavior and Brain Activity

    Shahar Arzy; Christine Mohr; Istvan Molnar-Szakacs; Olaf Blanke

    2011-01-01

    A fundamental trait of the human self is its continuum experience of space and time. Perceptual aberrations of this spatial and temporal continuity is a major characteristic of schizophrenia spectrum disturbances – including schizophrenia, schizotypal personality disorder and schizotypy. We have previously found the classical Perceptual Aberration Scale (PAS) scores, related to body and space, to be positively correlated with both behavior and temporo-parietal activation in healthy participan...

  14. Reliability of Accelerometer Scores for Measuring Sedentary and Physical Activity Behaviors in Persons With Multiple Sclerosis.

    Klaren, Rachel E; Hubbard, Elizabeth A; Zhu, Weimo; Motl, Robert W

    2016-04-01

    This brief research note examined the reliability of scores from an accelerometer as measures of sedentary and physical activity behaviors in persons with multiple sclerosis (MS). The analysis was performed on a combined data set from 2 previous longitudinal investigations of physical activity in MS. We focused on the number of days required to reliably estimate sedentary behavior, based on time spent in sedentary behavior per day and number of sedentary breaks, number of long sedentary bouts, and average length of sedentary bouts per day. We further examined the number of days required to reliably estimate physical activity behavior, based on time spent in light and moderate-to-vigorous physical activity and average length of activity bouts per day. Between 4-6 days of monitoring and 3-7 days of monitoring were necessary for good reliability of scores from all sedentary outcomes and physical activity outcomes, respectively. These results should guide research and practice examining sedentary and physical activity behaviors using accelerometry in persons with MS. PMID:27078272

  15. Characterization of the Antibacterial Activity and the Chemical Components of the Volatile Oil of the Leaves of <em>Rubus parvifoliusem> L.

    Yongqing Cai

    2012-06-01

    Full Text Available <em>Rubus parvifoliusem> L. (Rp is a medicinal herb that possesses antibacterial activity. In this study, we extracted the volatile oil from the leaves of Rp to assess its antibacterial activity and analyze its chemical composition. A uniform distribution design was used to optimize the extraction procedure, which yielded 0.36% (<em>w/w> of light yellowish oil from the water extract of Rp leaves. We found that the extracted oil effectively inhibited the growth of a wide range of Gram positive and negative bacteria, including <em>Staphylococcus aureusem>, <em>Staphylococcus epidermidisem>, <em>Enterococcus faecalisem>, <em>Escherichia coliem>, <em>Pseudomonas aeruginosaem>, <em>Acinetobacter baumaniiem>, <em>Bacillus cloacaeem>, and <em>Klebsiella pneumoniaeem>. We further analyzed the components contained in the hydro-distillated Rp volatile oil by gas chromatography-mass spectroscopy. Twenty nine compounds were identified, including 4-hydroxy-3-methoxystyrene (66%, 3,7,11,15-tetramethyl-2-hexadecen-1-ol (10% and 4-<em>tert>-butylbenzoic acid (2%. Our results suggest that one or multiple constituents contained in Rp volatile oil may account for its antibacterial activity.

  16. Identification of Volatile Components of Liverwort (<em>Porella cordaeanaem> Extracts Using GC/MS-SPME and Their Antimicrobial Activity

    Maria Elisabetta Guerzoni

    2012-06-01

    Full Text Available Chemical constituents of liverwort (<em>Porella cordaeanaem> extracts have been identified using solid-phase microextraction-gas chromatography mass spectrometry (SPME-GC/MS. The methanol, ethanol and ethyl acetate extracts were rich in terpenoids such as sesquiterpene hydrocarbons (53.12%, 51.68%, 23.16%, and monoterpene hydrocarbons (22.83%, 18.90%, 23.36%, respectively. The dominant compounds in the extracts were β-phellandrene (15.54%, 13.66%, 12.10% and β-caryophyllene (10.72%, 8.29%, 7.79%, respectively. The antimicrobial activity of the extracts was evaluated against eleven food microorganisms using the microdilution and disc diffusion methods. The minimum inhibitory concentration (MIC varied from 0.50 to 2.00 mg/mL for yeast strains (<em>Saccharomyces cerevisiae 635em>, <em>Zygosacharomyces bailii 45em>, <em>Aerobasidium pullulans L6Fem>, <em>Pichia membranaefaciens OC 71em>, <em>Pichia membranaefaciens OC 70em>, <em>Pichia anomalaem> <em>CBS 5759em>, <em>Pichia anomala DBVPG 3003em> and<em> em>>Yarrowia lipolytica RO13em>, and from 1.00 to 3.00 mg/mL for bacterial strains<em> em>(Salmonella> <em>enteritidis 155em>, <em>Escherichia coli 555em> and <em>Listeria monocytogenes 56Lyem>. Methanol extract showed better activity in comparison with ethanol and ethyl acetate extracts. High percentages of monoterpene and sesquiterpene hydrocarbons could be responsible for the better antimicrobial activity.

  17. Walkable scores for selected three east Texas counties: physical activity and policy implications

    Wycliffe W. Njororai Simiyu

    2015-09-01

    Full Text Available Introduction: Physical activity has become an important intervention against overweight and obesity cases in the USA and worldwide. One key aspect of physical activity is walking, which has been identified as a component that can easily be incorporated into one’s lifestyle. Recent studies on physical activity have focused on promoting walking as a health enhancing endeavor. In 2010, the proportion of Texas adults who reported no participation in leisure time activity (26.7% was significantly higher than the national average (24.4%. However, many Texans, like most Americans, are sedentary. Purpose: This study examined the walkability of the environments in selected counties in east Texas including Wood, Van Zandt and Smith counties. Methods and material: The data was drawn from the Walkscore.com and was based on all the zip codes in the three counties in east Texas. The community capitals were used a framework for analysis.  Results: Only three (8.82% zip codes had walkable scores between 70 and 89; five (14.71% had scores between 50 and 69; four (11.76% between 25 and 49 and 22 (64.71% had a score below 24. Discussion: The vast majority (26, 76.47% of zip codes are highly dependent on vehicle transport. Conclusions and recommendations: Stakeholders need therefore to focus on causes for the minimal walkability so that practical interventions are generated to enhance the physical activity friendly infrastructure so as to enhance the well-being of the residents in these three east Texas counties.

  18. Avaliação do EuroSCORE como preditor de mortalidade em cirurgia cardíaca valvar no Instituto do Coração de Pernambuco Assesment of the EuroSCORE as a predictor for mortality in valve cardiac surgery at the Heart Institute of Pernambuco

    Isaac Newton Guimarães Andrade

    2010-03-01

    Full Text Available OBJETIVO: Avaliar a aplicabilidade do Sistema Europeu de Risco em Operações Cardíacas (EuroSCORE em pacientes submetidos à cirurgia valvar no Instituto do Coração de Pernambuco. MÉTODOS: Foram incluídos no estudo 840 pacientes operados entre 2001 e 2009. Os prontuários desses doentes continham todas as informações que permitiram calcular o EuroSCORE. O desfecho de interesse foi óbito na internação. Com o objetivo de avaliar a aplicabilidade do EuroSCORE, foi usado o teste não paramétrico de Mann-Whitney. A calibração do modelo foi medida pela comparação da mortalidade observada com a esperada, usando-se o teste de bondade de ajuste de Hosmer-Lemershow. A acurácia do modelo foi avaliada pela curva ROC (receiver operating characteristic curve. RESULTADOS: A comparação entre a mortalidade prevista e a observada, por meio do teste de Hosmer-Lemershow, evidenciou boa capacidade preditiva (P=0,767, assim como quando comparada para cada valor do EuroSCORE Aditivo (P=0,455. Obteve-se uma área sob a curva de ROC de 0,731 (IC95% 0,660 - 0,793, com valor de P6 incluiu 131 pacientes, com mortalidade foi 20,6%. A análise de regressão logística permitiu identificar os seguintes fatores de risco para o óbito: idade acima de 60 anos, sexo feminino, operação prévia, endocardite ativa, cirurgia associada da aorta torácica e arteriopatia extracardíaca. CONCLUSÕES: O EuroSCORE, um método simples e objetivo, revelou-se um preditor satisfatório de mortalidade operatória e, por ele, foram identificados fatores de risco para o óbito em pacientes submetidos à cirurgia valvar no Instituto do Coração de Pernambuco.OBJECTIVE: To assess the applicability of the European Rysk System in Cardiac Operations (EuroSCORE in patients undergoing cardiac valve surgery at the Heart Institute of Pernambuco. METHOD: 840 patients operated on between 2001 and 2009, who medical records contained all the informations to calculate the EuroSCORE were

  19. The psychometric properties of ADCS - activities of daily living inventory and comparison of different ADL scores

    Rózsa, S.; Brandtmüller, A.; Nagy, B.; Brennan, A.(School of Physics, University of Melbourne, Victoria, Australia); Akehurst, R

    2009-01-01

    Several multi-item activities of daily living (ADL) scales have been developed for assessment of functional status of patients with Alzheimer’s Disease (AD) in the last few decades. A disadvantage of the large number of scales is that scores of different ADL scales cannot be compared directly with each other. ADL scales which are used by McNamee’s (Townsend's disability scale) and Hill’s (Medicare Beneficiary definitions and Katz index of ADL) provide suitable tools for modelling the cost-eff...

  20. EM international activities: May 1998 highlights

    NONE

    1998-05-01

    This publication is produced twice a year by the International Technology Systems Application staff. This issue is divided into the following sections: (1) Global Issues Facing Environmental Management; (2) Activities in Western Europe; (3) Activities in Central and Eastern Europe; (4) Activities in Russia; (5) Activities in Asia and the Pacific Rim; (6) Activities in South America; (7) Activities in North America; (8) Country studies; and (9) International Organizations. Some topics discussed are nuclear materials management, radioactive waste and hazardous waste management, and remedial action programs.

  1. EM international activities: May 1998 highlights

    This publication is produced twice a year by the International Technology Systems Application staff. This issue is divided into the following sections: (1) Global Issues Facing Environmental Management; (2) Activities in Western Europe; (3) Activities in Central and Eastern Europe; (4) Activities in Russia; (5) Activities in Asia and the Pacific Rim; (6) Activities in South America; (7) Activities in North America; (8) Country studies; and (9) International Organizations. Some topics discussed are nuclear materials management, radioactive waste and hazardous waste management, and remedial action programs

  2. Is there a preferred method for scoring activity of the spine by magnetic resonance imaging in ankylosing spondylitis?

    van der Heijde, Désirée; Landewé, Robert; Hermann, Kay-Geert; Rudwaleit, Martin; Østergaard, Mikkel; Oostveen, Ans; O'Connor, Phil; Maksymowych, Walter P; Lambert, Robert G; Lukas, Cédric; Jurik, Anne Grethe; Boers, Maarten; Baraliakos, Xenofon; Braun, Jürgen; NN, NN

    2007-01-01

    This report summarizes the discussion during a module update at OMERACT 8 on scoring methods for activity in the spine on magnetic resonance imaging. The conclusion was that the 3 available scoring methods are all very good with respect to discrimination and feasibility: the Ankylosing Spondylitis...

  3. Alimentary Habits, Physical Activity, and Framingham Global Risk Score in Metabolic Syndrome

    Metabolic syndrome is a complex disorder represented by a set of cardiovascular risk factors. A healthy lifestyle is strongly related to improve Quality of Life and interfere positively in the control of risk factors presented in this condition. To evaluate the effect of a program of lifestyle modification on the Framingham General Cardiovascular Risk Profile in subjects diagnosed with metabolic syndrome. A sub-analysis study of a randomized clinical trial controlled blind that lasted three months. Participants were randomized into four groups: dietary intervention + placebo (DIP), dietary intervention + supplementation of omega 3 (fish oil 3 g/day) (DIS3), dietary intervention + placebo + physical activity (DIPE) and dietary intervention + physical activity + supplementation of omega 3 (DIS3PE). The general cardiovascular risk profile of each individual was calculated before and after the intervention. The study included 70 subjects. Evaluating the score between the pre and post intervention yielded a significant value (p < 0.001). We obtained a reduction for intermediate risk in 25.7% of subjects. After intervention, there was a significant reduction (p < 0.01) on cardiovascular age, this being more significant in groups DIP (5.2%) and DIPE (5.3%). Proposed interventions produced beneficial effects for reducing cardiovascular risk score. This study emphasizes the importance of lifestyle modification in the prevention and treatment of cardiovascular diseases

  4. Disease activity score in rheumatoid arthritis with or without secondary fibromyalgia

    Objective: To correlate disease activity score (DAS-28) in the patients with rheumatoid arthritis (RA) with and without secondary fibromyalgia. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Rheumatology, Pakistan Institute of Medical Sciences, Islamabad, from November 2011 to April 2012. Methodology: Patients aged above 16 years diagnosed to have rheumatoid arthritis according to ACR/EULAR criteria 2010 were included in the study. Fibromyalgia (FM) was diagnosed by ACR 1990 criteria. Patients of other autoimmune diseases or psychiatric illnesses were excluded. DAS was determined and compared using t-test with significance at p < 0.05. Results: The mean age of study subjects was 42.9 years. Thirty one out of total 138 patients had fibromyalgia (22.4%). Female gender was predominant (92.0%); being 96.8% in patients with and in 88.2% without fibromyalgia. The average DAS score was high (5.3 + 1.5) in fibromyalgia patients compared to those without fibromyalgia (3.9 + 1.2); this difference in mean value was statistically significant (p = < 0.001). Conclusion: DAS-28 is a useful tool for assessing rheumatoid arthritis disease status in outpatient setting, however, increased disease activity must be assessed for possible co-existence of fibromyalgia which can spuriously give high DAS value and adversely affect treatment decision. (author)

  5. Alimentary Habits, Physical Activity, and Framingham Global Risk Score in Metabolic Syndrome

    Soares, Thays Soliman; Piovesan, Carla Haas; Gustavo, Andréia da Silva; Macagnan, Fabrício Edler; Bodanese, Luiz Carlos; Feoli, Ana Maria Pandolfo, E-mail: anamariafeoli@hotmail.com [Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS (Brazil)

    2014-04-15

    Metabolic syndrome is a complex disorder represented by a set of cardiovascular risk factors. A healthy lifestyle is strongly related to improve Quality of Life and interfere positively in the control of risk factors presented in this condition. To evaluate the effect of a program of lifestyle modification on the Framingham General Cardiovascular Risk Profile in subjects diagnosed with metabolic syndrome. A sub-analysis study of a randomized clinical trial controlled blind that lasted three months. Participants were randomized into four groups: dietary intervention + placebo (DIP), dietary intervention + supplementation of omega 3 (fish oil 3 g/day) (DIS3), dietary intervention + placebo + physical activity (DIPE) and dietary intervention + physical activity + supplementation of omega 3 (DIS3PE). The general cardiovascular risk profile of each individual was calculated before and after the intervention. The study included 70 subjects. Evaluating the score between the pre and post intervention yielded a significant value (p < 0.001). We obtained a reduction for intermediate risk in 25.7% of subjects. After intervention, there was a significant reduction (p < 0.01) on cardiovascular age, this being more significant in groups DIP (5.2%) and DIPE (5.3%). Proposed interventions produced beneficial effects for reducing cardiovascular risk score. This study emphasizes the importance of lifestyle modification in the prevention and treatment of cardiovascular diseases.

  6. Scoring inflammatory activity of the spine by magnetic resonance imaging in ankylosing spondylitis: a multireader experiment

    Lukas, Cédric; Braun, Jürgen; van der Heijde, Désirée;

    2007-01-01

    considered by the reader as the most abnormal, with additional scores for "depth" and "intensity." Both the order of the methods used by each reader and the timepoints (before/after treatment) were randomized. Feasibility of each scoring system was evaluated by measuring the mean time needed to score each....... Discriminatory ability was assessed using Z-scores (Mann-Whitney test) comparing change in score between patients treated with TNF-blocking drug and placebo. RESULTS: The mean time to score one set of MRI was shortest for the Berlin method. SDC was lowest for the Berlin method and highest for SPARCC. Overall...

  7. Evaluation of Antioxidant and Immunity-Enhancing Activities of <em>Sargassum pallidumem> Aqueous Extract in Gastric Cancer Rats

    Shen-Kang Zhou

    2012-07-01

    Full Text Available The effect of <em>Sargassum pallidumem> (brown seaweed aqueous extract on the immunity function and antioxidant activities in was studied gastric cancer rats. Treatment with <em>Sargassum pallidumem> aqueous extract at oral doses 400, 600 or 800 mg/kg body weight was found to provide a dose-dependent protection against <em>Nem>-methyl-N′-nitro-N>-nitrosoguanidine (MNNG-induced immunity damage and oxidative injury by enhancing serum interleukin-2 (IL-2, interleukin-4 (IL-4, interleukin-10 (IL-10 levels, decreasing interleukin-6 (IL-6, interleukin-1β (IL-1β, tumor necrosis factor-alpha (TNF-α levels, preserving normal antioxidant enzymes activities, and by inhibiting lipid peroxidation in gastric mucosa. It can be concluded that <em>Sargassum pallidumem> aqueous extract may enhance the immunity and antioxidant activities in gastric cancer rats.

  8. A multi-biomarker disease activity score for monitoring rheumatoid arthritis

    Hirata S

    2015-10-01

    physicians with a convenient measurement tool to monitor patients in a clinical setting and support rapid treatment adjustment and tighter disease control. This article examines peer-reviewed publications cited in PubMed that describe the multi-biomarker disease activity score, its development and validation, and its applications as an objective disease assessment tool in patients with RA. Keywords: algorithm, multi-biomarker disease activity score, disease activity, rheumatoid arthritis, Vectra DA

  9. Evaluation of Crohn's disease activity: Initial validation of a magnetic resonance enterography global score (MEGS) against faecal calprotectin

    To develop an MRI enterography global score (MEGS) of Crohn's disease (CD) activity compared with a reference standard of faecal calprotectin (fC), C-reactive protein (CRP) and Harvey-Bradshaw index (HBI). Calprotectin, CRP and HBI were prospectively recorded for 71 patients (median age 33, male 35) with known/suspected CD undergoing MRI enterography. Two observers in consensus scored activity for nine bowel segments, grading mural thickness, T2 signal, mesenteric oedema, T1 enhancement and pattern, and haustral loss. Segmental scores were multiplied according to disease length. Five points each were added for lymphadenopathy, comb sign, fistulae and abscesses to derive the MEGS. A previously validated MRI CD activity score (CDAS) was also calculated. MRI scores were correlated with clinical references using Spearman's rank. A logistic regression diagnostic model was built to discriminate active (fC > 100 μg/g) from inactive disease. MEGS and CDAS were significantly correlated with fC (r = 0.46, P < 0.001) and (r = 0.39, P = 0.001) respectively. MEGS correlated with CRP (r = 0.39, P = 0.002). The model for discriminating active from inactive disease achieved an area under the receiver-operating curve of 0.75 and 0.66 after leave-one-out analysis. A magnetic resonance enterography global score (MEGS) of CD activity correlated significantly with fC levels. (orig.)

  10. Reduced Photoinhibition under Low Irradiance Enhanced Kacip Fatimah (<em>Labisia pumila em>Benth) Secondary Metabolites, Phenyl Alanine Lyase and Antioxidant Activity

    Jaafar, Hawa Z. E.; Mohd Hafiz Ibrahim

    2012-01-01

    A randomized complete block design experiment was designed to characterize the relationship between production of total flavonoids and phenolics, anthocyanin, photosynthesis, maximum efficiency of photosystem II (Fv/Fm), electron transfer rate (Fm/Fo), phenyl alanine lyase activity (PAL) and antioxidant (DPPH) in <em>Labisia pumilaem> var. <em>alata,> em>under four levels of irradiance (225, 500, 625 and 900 µmol/m2/s) for...

  11. Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Xanthones Isolated from <em>Artocarpus obtususem> F.M. Jarrett

    Najihah Mohd. Hashim

    2012-05-01

    Full Text Available One of the most promising plants in biological screening test results of thirteen <em>Artocarpus em>species was <em>Artocarpus obtususem> FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1, dihydroartoindonesianin C (2 and pyranocycloartobiloxanthone B (3. These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1 exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant <em>Staphylococcus aureusem> (ATCC3359 and <em>Bacillus subtilisem> (clinically isolated with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1 displayed strong activity comparable with the standard kojic acid.

  12. Terpene Glycosides from the Roots of <em>Sanguisorba officinalisem> L. and Their Hemostatic Activities

    Wei Sun

    2012-06-01

    Full Text Available Guided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of <em>Sanguisorba officinalisem> L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified as citronellol-1-<em>O>-α-l-arabinofuranosyl-(1→6-β-d-glucopyranoside (1, geraniol-1-<em>O>-α-l-arabinofuranosyl-(1→6-β-d-glucopyranoside (2, geraniol-1-<em>O>-α-l-arabinopyranosyl-(1→6-β-d-glucopyranoside (3, 3β-[(α-l-arabinopyranosyloxy]-19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (4, 3β-[(α-l-arabinopyranosyl-oxy]-19α-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (ziyu-glycoside I, 5, 3β,19α-hydroxyolean-12-en-28-oic acid 28-β-d-glucopyranoside (6 and 3β,19α-di-hydroxyurs-12-en-28-oic acid 28-β-d-glucopyranoside (7. Compound 1 is a new mono-terpene glycoside and compounds 2, 3 and 5 were isolated from the <em>Sanguisorba> genus for the first time. Compounds 17 were assayed for their hemostatic activities with a Goat Anti-Human α2-plasmin inhibitor ELISA kit, and ziyu-glycoside I (5 showed the strongest hemostatic activity among the seven terpene glycosides. This is the first report that ziyu-glycoside Ι has strong hemostatic activity.

  13. Comparação entre provas de função pulmonar, escore de Shwachman-Kulczycki e escore de Brasfield em pacientes com fibrose cística Comparison among pulmonary function test results, the Shwachman-Kulczycki score and the Brasfield score in patients with cystic fibrosis

    Ivanice Duarte Freire

    2008-05-01

    . Spirometry findings, Shwachman-Kulczycki (S-K scores and Brasfield scores were analyzed. RESULTS: The final sample consisted of 40 patients (mean age 9.72 ± 3.27. The following mean S-K scores were obtained: total, 80.87 ± 10.24; general activity, 24.75 ± 1.1; physical examination, 18.87 ± 4.59; nutrition, 21.87 ± 4.18; radiology, 15.37 ± 5.23. The mean Brasfield score was 18.2 ± 4. The pulmonary function test results, in percentage of predicted, were as follows: forced vital capacity (FVC, 82.99 ± 14.36%; forced expiratory volume in one second (FEV1, 83.62 ± 18.26%; and forced expiratory flow between 25 and 75% of FVC (FEF25-75, 74.63 ± 2.53%. The S-K score correlated moderately with FVC, whereas it correlated strongly with FEV1 and FEF25-75. The Brasfield score correlated strongly with the S-K total and radiology score, whereas it correlated moderately with pulmonary function. Physical examination correlated moderately with FVC, FEV1 and FEF25-75; as did nutrition with FEF25-75; and radiology with FEV1 and FEF25-75. General activity was the domain that had the greatest influence on the total S-K score. CONCLUSIONS: These two scoring systems are complementary, correlating with each other, as well as with pulmonary function tests. The radiology domain of the S-K scoring system is a good alternative to the Brasfield score.

  14. Apgar Scores

    ... are more likely to have low scores than infants with normal births. These scores may reflect difficulties the baby experienced during labor or problems with her heart or respiratory system. What if Your Baby Scores Low? If your ...

  15. Escore de Framingham em motoristas de transportes coletivos urbanos de Teresina, Piauí Framingham score for public transportation drivers in the dity of Teresina, Piauí

    Maurício Batista Paes Landim

    2006-09-01

    Full Text Available OBJETIVO: Estimar o risco absoluto de contração de doença arterial coronariana, nos próximos 10 anos, em motoristas de transportes coletivos urbanos de Teresina, Piauí, segundo o escore de risco de Framingham. MÉTODOS: Foi realizado um estudo observacional, descritivo, transversal, aplicando-se o escore de Framingham, em 107 motoristas de transportes coletivos urbanos de Teresina, Piauí, para avaliação do grau de risco e sua associação com as variáveis previstas no mesmo, que foram: idade, colesterol total, colesterol HDL, pressão arterial sistólica, pressão arterial diastólica, presença de diabete melito e tabagismo. O teste de significância usado foi o c². Utilizou-se a razão de prevalência como medida de associação. RESULTADOS: O risco médio foi de 5%, com a maior parte situando-se na categoria de baixo risco (85,05%. As médias obtidas foram: 42 anos para a idade, colesterol total 200 mg%, colesterol HDL 49 mg%, pressão arterial sistólica 130 mmHg e pressão arterial diastólica 85 mmHg. As associações diabete melito, tabagismo e colesterol HDL, com o risco, não foram estatisticamente significantes, diferente do ocorrido com as outras variáveis, que tiveram grande influência no risco obtido. CONCLUSÃO: O risco absoluto médio estimado para os próximos 10 anos de doença arterial coronariana, em motoristas de transportes coletivos urbanos de Teresina, calculado pelo escore de Framingham, apresentou-se baixo. Uma parte considerável dos participantes da pesquisa (85,05% situou-se na categoria de baixo risco, ou seja, igual ou inferior a 10%.OBJECTIVE: To estimate the absolute risk of the public transportation drivers in the city of Teresina, Piauí, to develop coronary heart disease over the course of ten years based on the Framingham risk score. METHODS: An observational, descriptive, cross-sectional study using the Framingham score was conducted with 107 public transportation drivers in the city of Teresina

  16. Phenolics and Flavonoids Compounds, Phenylanine Ammonia Lyase and Antioxidant Activity Responses to Elevated CO2 in <em>Labisia pumilaem> (Myrisinaceae

    Hawa Z.E. Jaafar

    2012-05-01

    Full Text Available A split plot 3 × 3 experiment was designed to examine the impact of three concentrations of CO2 (400, 800 and 1,200 µmol·mol−1 on the phenolic and flavonoid compound profiles, phenylalanine ammonia lyase (PAL and antioxidant activity in three varieties of <em>Labisia pumilaem> Benth. (var. <em>alata,> pumila em>and> lanceolataem> after 15 weeks of exposure. HPLC analysis revealed a strong influence of increased CO2 concentration on the modification of phenolic and flavonoid profiles, whose intensity depended on the interaction between CO2 levels and <em>L. pumilaem> varieties. Gallic acid and quercetin were the most abundant phenolics and flavonoids commonly present in all the varieties. With elevated CO2 (1,200 µmol·mol−1 exposure, gallic acid increased tremendously, especially in var. <em>alata> and <em>pumila em>(101–111%, whilst a large quercetin increase was noted in var. <em>lanceolata> (260%, followed closely by <em>alata> (201%. Kaempferol, although detected under ambient CO2 conditions, was undetected in all varieties after exposure. Instead, caffeic acid was enhanced tremendously in var. <em>alata> (338~1,100% and <em>pumila em>(298~433%. Meanwhile, pyragallol and rutin were only seen in var. <em>alata> (810 µg·g−1 DW and <em>pumila> (25 µg·g−1 DW, respectively, under ambient conditions; but the former compound went undetected in all varieties while rutin continued to increase by 262% after CO2 enrichment. Interestingly, naringenin that was present in all varieties under ambient conditions went undetected under enrichment, except for var. <em>pumila em>where it was enhanced by 1,100%. PAL activity, DPPH and FRAP also increased with increasing CO2 levels implying the possible improvement of health-promoting quality of Malaysian <em>L. pumilaem

  17. Serum interleukin-18 and interleukin-10 levels in systemic lupus erythematosus: correlation with SLEDAI score and disease activity parameters

    Sahar Abou El-Fetouh

    2014-01-01

    Conclusion The circulating IL-18 and IL-10 concentrations were significantly elevated in SLE patients and correlated with the SLEDAI score. The study emphasized that there exists an upregulated proinflammatory as well as anti-inflammatory responses in patients with active SLE; however, the anti-inflammatory response is not enough to suppress the active disease. Identifying the exact contribution of the currently studied cytokines might provide future insights for targeted therapeutic strategies in SLE.

  18. CORRELATION OF PEMPHIGUS VULGARIS ANTIBODY TITERS BY INDIRECT IMMUNOFLUORESCENCE WITH ACTIVITY OF DISEASE BASED ON PEMPHIGUS AREA AND ACTIVITY SCORE (PAAS

    H. Mortazavi

    2008-06-01

    Full Text Available Indirect immunofluorescence (IIF has been used to identify and measure autoantibody levels in pemphigus vulgaris but data about relationship between clinical severity of disease and antibody titers by IIF have been conflicting. We conducted this cross-sectional study to correlate the severity of oral and/or cutaneous involvement in patients with pemphigus vulgaris based on Pemphigus Area and Activity Score with IIF titers. Sixty-one new pemphigus vulgaris patients were included in this study. Human prepuce was used as substrate for IIF and assessment of disease severity was based on Pemphigus Area and Activity Score. The mean±SD age was 44.04±30.46 years, with a range of 18 to 79 years. IIF was positive in 56 (91.8% patients. There was a significant relationship between total disease score and IIF titers ((P<0.001. Also a significant relationship was found between skin score (P=0.04 and mucosal score (P=0.04 with IIF titers. Our results show that there is a significant relationship between disease activity based on Pemphigus Area and Activity Score and antibody titers by IIF. Further studies are recommended to determine the usefulness of this technique for monitoring disease.

  19. Avaliação do Escore NNECDSG em um hospital público brasileiro Evaluation of the NNECDSG Score in a Brazilian public hospital

    Tatiana Maia Jorge de Ulhôa Barbosa

    2007-06-01

    Full Text Available OBJETIVO: Comparar as incidências observadas de mediastinite e acidente vascular cerebral (AVC versus as incidências esperadas pelo escore NNECDSG (Northern New England Cardiovascular Disease Study Group, em população submetida à cirurgia de revascularização do miocárdio. MÉTODO: Foram analisados, retrospectivamente, os prontuários de todos os pacientes submetidos à CRVM isolada, no período de 1/1/2000 a 31/12/2004, no Serviço de Cirurgia Cardíaca da Universidade Federal do Triângulo Mineiro (UFTM. Foi aplicado o escore proposto pelo NNECDSG e calculadas as incidências esperadas de mediastinite e AVC para cada paciente. Os dados de incidência observados e a incidência estimada pelo escore do NNECDSG foram submetidos ao teste de normalidade de Kolmogorov-Smirnov. A comparação foi realizada pelo teste t-Student pareado. O nível de significância foi de alfa=0,05. RESULTADOS: Foram analisados 230 pacientes, sendo 144 (62,60% homens e 86 (37,39% mulheres. Sessenta e um (26,52% doentes apresentavam diabetes, 30 (13,04%, doença pulmonar obstrutiva crônica (DPOC e 23 (10%, doença vascular periférica (DVP. Cirurgia de urgência aconteceu em 34 (14,78% casos. Trinta e sete (16,08% pacientes tinham uma fração de ejeção (FE menor que 40%. Mediastinite ocorreu em 12 (5,21% pacientes. Apesar da incidência geral de mediastinite ter sido maior nesta amostra, não houve significância estatística. AVC ocorreu em 12 (5,21% pacientes. Apesar da incidência percentual média de AVC observada ter sido maior, não atingiu nível de significância estatística. CONCLUSÃO: Apesar das incidências de mediastinite e AVC terem sido maiores na população estudada, estes valores não atingiram significância estatística, sendo o escore preconizado pela NNECDSG um método seguro e eficaz na predição de mediastinite e AVC pós-operatórios nos pacientes submetidos à CRVM na UFTM.OBJECTIVE: To compare the observed incidence of

  20. Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants

    Terrence M. Vance

    2015-01-01

    Full Text Available Background. Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US. Growing evidence suggests that oxidative stress is involved in prostate cancer. Methods. In this study, thioredoxin 1 (Trx 1, an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project. A pathologist blindly scored levels of Trx 1. The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher’s exact test. Results. Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P=0.01 and inversely associated with dietary antioxidant intake (P=0.03. In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P=0.01. No association was found for other erythrocyte enzymes. Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P=0.04. Conclusion. These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants.

  1. Chemical Composition and <em>in Vitroem> Evaluation of the Antioxidant and Antimicrobial Activities of <em>Eucalyptus gillii em>Essential Oil and Extracts<em>>

    François Couderc

    2012-08-01

    Full Text Available In this study, essential oil and various extracts (hexane, petroleum ether, acetone, ethanol, methanol and water of <em>Eucalyptus giliiem> were screened for their chemical composition, antimicrobial and antioxidant activities. The essential oil chemical composition was analyzed by gas chromatography-mass spectrometry (GC-MS and gas chromatography-flame ionization detection (GC-FID, respectively. Thirty four compounds were identified, corresponding to 99.5% of the total essential oil. Tannins [104.9–251.3 g catechin equivalent (CE/Kg dry mass], flavonoids [3.3–34.3 g quercetin equivalent (QE/Kg dry mass], phenolics [4.7–216.6 g gallic acid equivalent (GAE/Kg dry mass] and anthocyannins [1.2–45.3 mg cyanidin-3-glucoside equivalent (C3GE/Kg dry mass] of various extracts were investigated. Free radical scavenging capacity of all samples was determinedt. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH assay, the IC50 of essential oil was 163.5 ± 10.7 mg/L and in the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulphonate (ABTS assay, it was 94.7 ± 7.1 mg/L. Among the various extracts, the water extract showed the best result (IC50 = 11.4 ± 0.6 mg/L in the DPPH assay which was comparable to vitamin C (IC50 = 4.4 ± 0.2 mg/L. The antimicrobial activities were evaluated against different bacterial and fungal strains. Gram positive bacteria were found to be more sensitive to the essential oil and extracts than Gram negative ones. Anthocyanins seem to have a major effect on the growth of <em>Bacillus subtilisem> (R2 = 0.79. A significant antifungal activity was observed against the yeast and fungi. Correlations between chemical composition and antioxidant activities were studied and R2 values were about 0.96 for the effect of phenolics on the DPPH assay.

  2. A melanoma risk score in a Brazilian population Um escore de risco para melanoma em uma população brasileira

    Lucio Bakos

    2013-04-01

    Full Text Available BACKGROUND: Important risk factors for cutaneous melanoma (CM are recognized, but standardized scores for individual assessment must still be developed. OBJECTIVES: The objective of this study was to develop a risk score of CM for a Brazilian sample. METHODS: To verify the estimates of the main risk factors for melanoma, derived from a meta-analysis (Italian-based study, and externally validate them in a population in southern Brazil by means of a case-control study. A total of 117 individuals were evaluated. Different models were constructed combining the summary coefficients of different risk factors, derived from the meta-analysis, multiplied by the corresponding category of each variable for each participant according to a mathematical expression. RESULTS: the variable that best predicted the risk of CM in the studied population was hair color (AUC: 0.71; 95% CI: 0.62-0.79. Other important factors were freckles, sunburn episodes, and skin and eye color. Consideration of other variables such as common nevi, elastosis, family history, and premalignant lesions did not improve the predictive ability of the models. CONCLUSION: The discriminating capacity of the proposed model proved to be superior or comparable to that of previous risk models proposed for CM. FUNDAMENTOS: importantes fatores de risco para melanoma cutâneo são reconhecidos, mas escores padronizados para avaliação individual ainda precisam ser elaborados. OBJETIVOS: o objetivo deste estudo foi desenvolver um escore de risco de melanoma cutâneo para uma amostra brasileira. MÉTODOS: verificar as estimativas dos principais fatores de risco para melanoma, derivado de uma meta-análise (estudo de base italiano e, externamente, validar em uma população do sul do Brasil por um estudo caso-controle. Um total de 117 indivíduos foram avaliados. RESULTADOS: a variável com maior poder preditivo para o risco de melanoma cutâneo na população estudada foi a cor do cabelo (AUC: 0

  3. Anti-Hepatitis B Virus Activity of Chickweed [<em>Stellaria mediaem> (L. Vill.] Extracts in HepG2.2.15 Cells

    Donghao Xie

    2012-07-01

    Full Text Available <em>Stellaria media em>(Linn. Villars is a traditional Chinese medicine that has been used for over 200 years, mainly for the treatment of dermatitis and other skin diseases. It has also been used as an anti-viral agent. All the fresh chickweed juice samples used in this study were prepared using macroporous resin and ultrafiltration technology. The anti-hepatitis B virus (HBV activity of <em>S. media em>was evaluated<em> in vitroem> using the human HBV-transfected liver cell line HepG2.2.15. The concentrations of hepatitis B surface antigen (HBsAg and hepatitis B e antigen (HBeAg in HepG2.2.15 cell culture medium were determined by enzyme-linked immunosorbent assay (ELISA after <em>S. mediaem>-n (SM-n treatment for 6 or 9 days. HBV DNA was quantified using transcription-mediated amplification and real-time polymerase chain reaction. In HepG2.2.15 cells, 30 μg/mL SM-3 effectively suppressed the secretion of HBsAg and HBeAg with inhibition rates of 27.92% and 25.35% after 6 days of treatment, respectively. Consistent with the reduction in HBV antigens, SM-3 also reduced the level of HBV DNA in a dose-dependent manner. The characterization and quantitation of the chemical composition of SM-3 showed the presence of flavonoid C-glycosides, polysaccharides, and protein, which exhibited diverse antiviral activities. In conclusion, our results demonstrate that SM-3 possesses potential anti-HBV activity> in vitroem>. This is the first report demonstrating the anti-HBV effects of <em>S. mediaem>, which is currently under early development as a potential anti-HBV drug candidate.

  4. A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis.

    Suppiah, Ravi

    2011-05-01

    Assessment of disease activity in vasculitis can be achieved using the BVAS, a clinical checklist of relevant symptoms, signs and features of active disease. The aim of this study was to revalidate the BVAS version 3 (BVAS v. 3) in a cohort of patients with systemic vasculitis.

  5. Modeling complexity in pathologist workload measurement: the Automatable Activity-Based Approach to Complexity Unit Scoring (AABACUS).

    Cheung, Carol C; Torlakovic, Emina E; Chow, Hung; Snover, Dale C; Asa, Sylvia L

    2015-03-01

    Pathologists provide diagnoses relevant to the disease state of the patient and identify specific tissue characteristics relevant to response to therapy and prognosis. As personalized medicine evolves, there is a trend for increased demand of tissue-derived parameters. Pathologists perform increasingly complex analyses on the same 'cases'. Traditional methods of workload assessment and reimbursement, based on number of cases sometimes with a modifier (eg, the relative value unit (RVU) system used in the United States), often grossly underestimate the amount of work needed for complex cases and may overvalue simple, small biopsy cases. We describe a new approach to pathologist workload measurement that aligns with this new practice paradigm. Our multisite institution with geographically diverse partner institutions has developed the Automatable Activity-Based Approach to Complexity Unit Scoring (AABACUS) model that captures pathologists' clinical activities from parameters documented in departmental laboratory information systems (LISs). The model's algorithm includes: 'capture', 'export', 'identify', 'count', 'score', 'attribute', 'filter', and 'assess filtered results'. Captured data include specimen acquisition, handling, analysis, and reporting activities. Activities were counted and complexity units (CUs) generated using a complexity factor for each activity. CUs were compared between institutions, practice groups, and practice types and evaluated over a 5-year period (2008-2012). The annual load of a clinical service pathologist, irrespective of subspecialty, was ∼40,000 CUs using relative benchmarking. The model detected changing practice patterns and was appropriate for monitoring clinical workload for anatomical pathology, neuropathology, and hematopathology in academic and community settings, and encompassing subspecialty and generalist practices. AABACUS is objective, can be integrated with an LIS and automated, is reproducible, backwards compatible

  6. Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules

    Nassiri, Isar; Lombardo, Rosario; Lauria, Mario; Morine, Melissa J.; Moyseos, Petros; Varma, Vijayalakshmi; Nolen, Greg T.; Knox, Bridgett; Sloper, Daniel; Kaput, Jim; Priami, Corrado

    2016-07-01

    The investigation of the complex processes involved in cellular differentiation must be based on unbiased, high throughput data processing methods to identify relevant biological pathways. A number of bioinformatics tools are available that can generate lists of pathways ranked by statistical significance (i.e. by p-value), while ideally it would be desirable to functionally score the pathways relative to each other or to other interacting parts of the system or process. We describe a new computational method (Network Activity Score Finder - NASFinder) to identify tissue-specific, omics-determined sub-networks and the connections with their upstream regulator receptors to obtain a systems view of the differentiation of human adipocytes. Adipogenesis of human SBGS pre-adipocyte cells in vitro was monitored with a transcriptomic data set comprising six time points (0, 6, 48, 96, 192, 384 hours). To elucidate the mechanisms of adipogenesis, NASFinder was used to perform time-point analysis by comparing each time point against the control (0 h) and time-lapse analysis by comparing each time point with the previous one. NASFinder identified the coordinated activity of seemingly unrelated processes between each comparison, providing the first systems view of adipogenesis in culture. NASFinder has been implemented into a web-based, freely available resource associated with novel, easy to read visualization of omics data sets and network modules.

  7. Effects of type of physical exercise and leisure activities on the depression scores of obese Brazilian adolescent girls

    S.G. Stella

    2005-11-01

    Full Text Available Several studies have indicated that depressive states may lead to hypokinesia with diminished metabolic rate and energy use. Hypokinesia associated with certain eating behaviors may lead to an unfavorable energy balance that can contribute to the emergence and prevalence of obesity among children and adults. The purpose of the present study was to examine the possibility of reducing depression inventory scores in female adolescents with third-degree obesity while testing the effectiveness of different exercise programs in reducing anxiety and depression scores. The sample consisted of 40 female subjects (mean age 16 ± 1.56 years divided into 4 groups (aerobic training, anaerobic training, leisure activities, and control. Subjects had a body mass index of 95% or more in relation to the 50th percentile. The aerobic program consisted of three ergometric bicycle sessions per week over a 3-month period (12 weeks and the activities were prescribed after determining the anaerobic ventilatory threshold (VO2 threshold. Anaerobic training was based on the Wingate anaerobic power test. The leisure program consisted of a varied range of activities (games, exercises, etc.. A nutritionist interviewed the members of these two groups and the control group every week in order to adapt them to the nutritional guidelines proposed for the study. The study showed that all three programs (aerobic exercise, anaerobic exercise and leisure activities were effective in reducing body mass. However, we found a significant reduction when analyzing the depression scores only for aerobic exercise (18.9 ± 9.33 to 10.6 ± 9.56 or 43.9% but no significant alterations for anaerobic exercise (11.36 ± 5.23 to 9.63 ± 4.78 or 15.22% and leisure (17.28 ± 7.55 to 15.07 ± 7.54 or 12.78%, thus indicating that in principle this type of activity could be included to improve emotional well-being of obese adolescent girls.

  8. Two new atom centered fragment descriptors and scoring function enhance classification of antibacterial activity.

    Kandel, Durga Datta; Raychaudhury, Chandan; Pal, Debnath

    2014-04-01

    Classification of pharmacologic activity of a chemical compound is an essential step in any drug discovery process. We develop two new atom-centered fragment descriptors (vertex indices)--one based solely on topological considerations without discriminating atom or bond types, and another based on topological and electronic features. We also assess their usefulness by devising a method to rank and classify molecules with regard to their antibacterial activity. Classification performances of our method are found to be superior compared to two previous studies on large heterogeneous data sets for hit finding and hit-to-lead studies even though we use much fewer parameters. It is found that for hit finding studies topological features (simple graph) alone provide significant discriminating power, and for hit-to-lead process small but consistent improvement can be made by additionally including electronic features (colored graph). Our approach is simple, interpretable, and suitable for design of molecules as we do not use any physicochemical properties. The singular use of vertex index as descriptor, novel range based feature extraction, and rigorous statistical validation are the key elements of this study. PMID:24664120

  9. A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis

    Suppiah, Ravi; Mukhtyar, Chetan; Flossmann, Oliver; Alberici, Federico; Baslund, Bo; Batra, Rajbir; Brown, Denise; Holle, Julia; Hruskova, Zdenka; Jayne, David R W; Judge, Andrew; Little, Mark A; Palmisano, Alessandra; Stegeman, Coen; Tesar, Vladimir; Vaglio, Augusto; Westman, Kerstin; Luqmani, Raashid

    2011-01-01

    and the vasculitis damage index (VDI) to demonstrate that the BVAS v. 3 measures disease activity. Results. WG (63%), Churg-Strauss syndrome (9%) and microscopic polyangiitis (9%) were the most common diagnoses. The BVAS v. 3 showed convergent validity with the VAI [¿¿=¿0.82 (95% CI 0.77, 0.85)], PGA...... [¿¿=¿0.85 (95% CI 0.81, 0.88)] and the physician's treatment decision [¿¿=¿0.54 (95% CI 0.44, 0.62)]. There was little or no correlation between BVAS v. 3 and the CRP level [¿¿=¿0.18 (95% CI 0.05, 0.30)] or with the VDI [¿¿=¿-0.10 (95% CI 0.22, 0.03)]. The inter-observer reliability was very high with an...

  10. Validity and predictive ability of the juvenile arthritis disease activity score based on CRP versus ESR in a Nordic population-based setting

    Nordal, E B; Zak, Marek Stanislaw; Aalto, K;

    2012-01-01

    To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS based on erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate JADAS in a population-based setting.......To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS based on erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate JADAS in a population-based setting....

  11. The creation of a healthy eating motivation score and its association with food choice and physical activity in a cross sectional sample of Irish adults

    Naughton, Paul; McCarthy, Sinéad N.; McCarthy, Mary B.

    2015-01-01

    Background This study aimed to develop a healthy eating motivation score and to determine if dietary, lifestyle and activity behaviours vary across levels of motivation to eat a healthy diet with a view to informing health promotion interventions. Methods A cross-sectional survey of food intake, physical activity, lifestyles and food choice attitudes was conducted in a nationally representative sample of 1262 adults in the Republic of Ireland aged 18 years and over. Results Increasing score f...

  12. Evaluation of Crohn's disease activity: Initial validation of a magnetic resonance enterography global score (MEGS) against faecal calprotectin

    Makanyanga, Jesica C.; Dikaios, Nikolaos [University College London, Centre for Medical Imaging, London (United Kingdom); Pendse, Doug; Atkins, Elaine; Cuthbertson, Terry [University College London Hospitals, Department of Specialist Radiology, London (United Kingdom); Bloom, Stuart; McCartney, Sara; Forbes, Alastair [University College London Hospitals, Department of Gastroenterology, London (United Kingdom); Helbren, Emma; Punwani, Shonit; Halligan, Steve; Taylor, Stuart A. [University College London, Centre for Medical Imaging, London (United Kingdom); University College London Hospitals, Department of Specialist Radiology, London (United Kingdom)

    2014-02-15

    To develop an MRI enterography global score (MEGS) of Crohn's disease (CD) activity compared with a reference standard of faecal calprotectin (fC), C-reactive protein (CRP) and Harvey-Bradshaw index (HBI). Calprotectin, CRP and HBI were prospectively recorded for 71 patients (median age 33, male 35) with known/suspected CD undergoing MRI enterography. Two observers in consensus scored activity for nine bowel segments, grading mural thickness, T2 signal, mesenteric oedema, T1 enhancement and pattern, and haustral loss. Segmental scores were multiplied according to disease length. Five points each were added for lymphadenopathy, comb sign, fistulae and abscesses to derive the MEGS. A previously validated MRI CD activity score (CDAS) was also calculated. MRI scores were correlated with clinical references using Spearman's rank. A logistic regression diagnostic model was built to discriminate active (fC > 100 μg/g) from inactive disease. MEGS and CDAS were significantly correlated with fC (r = 0.46, P < 0.001) and (r = 0.39, P = 0.001) respectively. MEGS correlated with CRP (r = 0.39, P = 0.002). The model for discriminating active from inactive disease achieved an area under the receiver-operating curve of 0.75 and 0.66 after leave-one-out analysis. A magnetic resonance enterography global score (MEGS) of CD activity correlated significantly with fC levels. (orig.)

  13. Credit scoring

    Sánchez Bilbao, Pablo

    2015-01-01

    RESUMEN: El credit scoring es un sistema de modelos de decisión a través del cual se calcula la probabilidad de que un sujeto sea capaz de devolver o no un crédito comercial. Este trabajo realiza una simulación de este modelo con la intención de familiarizarse con el funcionamiento del mismo, así como con el marco teórico que este conlleva. El uso del credit scoring da respuesta a un problema generalizado en las entidades financieras como es la correcta estimación y valoración del riesg...

  14. Variation in dietary intake and physical activity pattern as predictors of change in body mass index (BMI Z-score among Brazilian adolescents*

    Carla C. Enes

    2013-06-01

    Full Text Available Objective: To assess whether changes in dietary intake and physical activity pattern are associated with the annual body mass index (BMI z-score change among adolescents. Methods: The study was conducted in public schools in the city of Piracicaba, Sao Paulo, Brazil, with a probabilistic sample of 431 adolescents participating in wave I (2004 (hereafter, baseline and 299 in wave II (2005 (hereafter, follow-up. BMI, usual food intake, physical activity, screen time, sexual maturation and demographic variables were assessed twice. The association between annual change in food intake, physical activity, screen time, and annual BMI z-score changes were assessed by multiple regression. Results: The study showed a positive variation in BMI z-score over one-year. Among variables related to physical activity pattern only playing videogame and using computer increased over the year. The intake of fruits and vegetables and sugar-sweetened beverages increased over one year, while the others variables showed a reduction. An increased consumption of fatty foods (β = 0.04, p = 0.04 and sweetened natural fruit juices (β = 0.05, p = 0.03 was positively associated with the rise in BMI z-score. Conclusions: Unhealthy dietary habits can predict the BMI z-score gain more than the physical activity pattern. The intake of fatty foods and sweetened fruit juices is associated with the BMI z-score over one year.

  15. Analytical laboratory quality assurance guidance in support of EM environmental sampling and analysis activities

    This document introduces QA guidance pertaining to design and implementation of laboratory procedures and processes for collecting DOE Environmental Restoration and Waste Management (EM) ESAA (environmental sampling and analysis activities) data. It addresses several goals: identifying key laboratory issues and program elements to EM HQ and field office managers; providing non-prescriptive guidance; and introducing environmental data collection program elements for EM-263 assessment documents and programs. The guidance describes the implementation of laboratory QA elements within a functional QA program (development of the QA program and data quality objectives are not covered here)

  16. Analytical laboratory quality assurance guidance in support of EM environmental sampling and analysis activities

    1994-05-01

    This document introduces QA guidance pertaining to design and implementation of laboratory procedures and processes for collecting DOE Environmental Restoration and Waste Management (EM) ESAA (environmental sampling and analysis activities) data. It addresses several goals: identifying key laboratory issues and program elements to EM HQ and field office managers; providing non-prescriptive guidance; and introducing environmental data collection program elements for EM-263 assessment documents and programs. The guidance describes the implementation of laboratory QA elements within a functional QA program (development of the QA program and data quality objectives are not covered here).

  17. Avaliação da carga de trabalho no pós-operatório de cirurgia cardíaca segundo o Nursing Activities Score

    Larissa Bertacchini de Oliveira

    2015-12-01

    Full Text Available RESUMO Objetivo Identificar os fatores associados à carga de trabalho de enfermagem no cuidado a pacientes no pós-operatório de cirurgia cardíaca. Método Estudo de coorte prospectivo, conduzido com 187 pacientes da Unidade de Terapia Intensiva Cirúrgica (UTI do Instituto do Coração. Os dados foram coletados nas primeiras 24 e 72 horas do paciente na UTI. A variável dependente foi a carga de trabalho calculada por meio do Nursing Activities Score (NAS e as independentes foram de natureza demográfico-clínicas e escores de morbimortalidade. Para análise dos dados utilizou-se os testes de Wilcoxon-Mann-Whitney e de correlação de Spearman, e a regressão linear com modelo de efeitos mistos. Resultados A maioria dos pacientes era do sexo masculino (59,4%, com média de idade de 61 anos (±12,7 e 43,9% desenvolveram algum tipo de complicação no pós-operatório. Nas 24 horas, a carga de trabalho foi de 82,4% (±3,4 e foi de 58,1% (±3,4 nas 72 horas. Os fatores associados ao aumento do NAS foram: tempo de internação do paciente na UTI (p=0,036 e a presença de complicações (p<0,001. Conclusão A gravidade do paciente nas 24 horas, em oposição a inúmeros estudos, não influenciou no aumento da carga de trabalho, a qual se mostrou associada ao tempo de internação e às complicações.

  18. Terpene Glycosides from the Roots of <em>Sanguisorba officinalisem> L. and Their Hemostatic Activities

    Wei Sun; Zi-Long Zhang; Xin Liu; Shuang Zhang; Lu He; Zhe Wang; Guang-Shu Wang

    2012-01-01

    Guided by a hemostasis bioassay, seven terpene glycosides were isolated from the roots of <em>Sanguisorba officinalisem> L. by silica gel column chromatography and preparative HPLC. On the grounds of chemical and spectroscopic methods, their structures were identified as citronellol-1-<em>O>-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (1), geraniol-1-<em>O>-α-l-arabinofuranosyl-(1→6)-β-d-glucopyranoside (

  19. Score Correlation

    Fabián, Zdeněk

    2010-01-01

    Roč. 20, č. 6 (2010), s. 793-798. ISSN 1210-0552 R&D Projects: GA ČR GA205/09/1079 Institutional research plan: CEZ:AV0Z10300504 Keywords : score function * correlation * rank correlation coefficient * heavy tails Subject RIV: BB - Applied Statistics, Operational Research Impact factor: 0.511, year: 2010

  20. Score Correlation

    Fabián, Z. (Zdeněk)

    2010-01-01

    In this paper, we study a distribution-dependent correlation coefficient based on the concept of scalar score. This new measure of association of continuous random variables is compared by means of simulation experiments with the Pearson, Kendall and Spearman correlation coefficients.

  1. Therapeutic intervention scoring system application in a pediatric intensive care unit Aplicação do índice de intervenção terapêutica em unidade de terapia intensiva pediátrica

    Pedro Celiny Ramos Garcia

    2009-08-01

    Full Text Available Introduction: Indices of gravity aim to estimate the disease’s severity. The Therapeutic Intervention Scoring System – 28 (TISS-28 is used in Intensive Care Units as an indirect index to estimate the disease`s gravity interval, which has also been recently used to relate the nursing workload Objective: To review each operational item/definition of the Therapeutic Intervention Scoring System (TISS-28, making a re-reading in order to systematize the data collection practice in Pediatric Intensive Care Units (PICUs. Materials and Methods: An integrative revision research of medical and nursing literature through the base of data from Medical Literature Analysis and Retrieval System Online (MEDLINE and Scientific Electronic Library Online (SciELO using the terms Intensive Care Units, scales and Therapeutic Intervention Scoring System-28 or TISS-28. The articles were selected according to their relevance, as the authors opinion. Results: Preliminary studies show that the use of TISS-28 in ICU of adults patients, has helped in the evolutionary clinical assessment of the patient’s worsening, besides associations between death and elevated scores. The items/operational definitions evaluated in this score are reviewed in order to facilitate the interpretation of each item in the TISS -28 daily application in Pediatric Intensive Care Unit (PICU. Conclusion: The daily assessment of the 28 TISS variables allows the acquirement of an evolutionary profile of hospitalized children, which can help to increase the knowledge of the hospitalized child clinical picture and its prognosis.Introdução: Índices de gravidade buscam estimar a severidade da doença, sendo o Therapeutic Intenvention Scoring System-28 (Sistema de Escore de Intervenção Terapêutica - TISS-28, usado em Unidades de Terapia Intensiva, um índice indireto para estimar intervalos de gravidade da doença que mais recentemente tem sido usado para relacionar a carga de trabalho de

  2. Synthesis and Cytotoxic Activity of Some Novel <em>N>-Pyridinyl-2-(6-phenylimidazo[2,1-<em>b>]thiazol-3-ylacetamide Derivatives

    Huaiwei Ding

    2012-04-01

    Full Text Available A series of novel compounds bearing imidazo[2,1-<em>b>]thiazole scaffolds were designed and synthesized based on the optimization of the virtual screening hit compound <em>N>-(6-morpholinopyridin-3-yl-2-(6-phenylimidazo[2,1-b]thiazol-3-ylacetamide (5a, and tested for their cytotoxicity against human cancer cell lines, including HepG2 and MDA-MB-231. The results indicated that the compound 2-(6-(4-chlorophenylimidazo[2,1-b]thiazol-3-yl-N-(6-(4-(4-methoxybenzylpiperazin-1-ylpyridin-3-ylacetamide (5l, with slightly higher inhibition on VEGFR2 than 5a (5.72% and 3.76% inhibitory rate at 20 μM, respectively, was a potential inhibitor against MDA-MB-231 (IC50 = 1.4 μM compared with sorafenib (IC50 = 5.2 μM, and showed more selectivity against MDA-MB-231 than HepG2 cell line (IC50 = 22.6 μM.

  3. Responsiveness of the Ankylosing Spondylitis Disease Activity Score (ASDAS) and clinical and MRI measures of disease activity in a 1-year follow-up study of patients with axial spondyloarthritis treated with tumour necrosis factor alpha inhibitors

    Pedersen, Susanne Juhl; Sørensen, Inge Juul; Hermann, Kay-Geert A; Madsen, Ole Rintek; Tvede, Niels; Hansen, Michael Sejer; Thamsborg, Gorm; Andersen, Lis Smedegaard; Majgaard, Ole; Loft, Anne Gitte; Erlendsson, Jon; Asmussen, Karsten Heller; Johansen, Julia S; Jurik, Anne Grethe; Møller, Jakob Møllenbach; Hasselquist, Maria; Mikkelsen, Dorrit; Skjødt, Thomas; Hansen, Annette; Østergaard, Mikkel

    2010-01-01

    To investigate construct validity and responsiveness of the novel ankylosing spondylitis (AS) disease activity score (ASDAS) in patients with spondyloarthritis (SpA).......To investigate construct validity and responsiveness of the novel ankylosing spondylitis (AS) disease activity score (ASDAS) in patients with spondyloarthritis (SpA)....

  4. An external validation study reporting poor correlation between the claims-based index for rheumatoid arthritis severity and the disease activity score

    Desai, Rishi J; Solomon, Daniel H; Weinblatt, Michael E.; Shadick, Nancy; Kim, Seoyoung C

    2015-01-01

    Introduction: We conducted an external validation study to examine the correlation of a previously published claims-based index for rheumatoid arthritis severity (CIRAS) with disease activity score in 28 joints calculated by using C-reactive protein (DAS28-CRP) and the multi-dimensional health assessment questionnaire (MD-HAQ) physical function score. Methods: Patients enrolled in the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS) and Medicare were identified and t...

  5. Aplicação do escore CRIB como preditor de óbito em unidade de terapia intensiva neonatal: uma abordagem ampliada The use of CRIB score as mortality predictor at neonatal intensive care unit: an extended approach

    Luiz Fernando C. Nascimento

    2004-06-01

    Full Text Available OBJETIVOS: avaliar o uso do escore CRIB (Clinical Risk Index for Babies em todos os recém-nascidos internados em Unidade de Terapia Intensiva Neonatal (UTIN e comparar seus resultados com peso ao nascer e idade gestacional. MÉTODOS: estudo observacional, envolvendo todos os recém-nascidos internados na UTIN do Hospital Universitário de Taubaté. As variáveis foram escore CRIB, peso ao nascer, idade gestacional, uso de surfactante, cateterização umbilical, asfixia neonatal e óbito. Foram comparadas as médias do escore CRIB, peso ao nascer e idade gestacional segundo óbito. Foram estimados os valores da sensibilidade, especificidade, valores preditivos positivo e negativo e risco relativo e criadas curvas Receiver Operating Characteristic (ROC para CRIB, peso ao nascer e idade gestacional. Utilizou-se da técnica t de Student e qui-quadrado de tendência linear. A significância estatística foi alfa = 5%. RESULTADOS: óbito esteve associado a maiores valores do CRIB; houve tendência de mais casos com asfixia, uso de surfactante, cateterização umbilical e óbitos com as classes maiores do CRIB. A curva ROC relativa ao CRIB foi maior que as relativas ao peso ao nascer e idade gestacional. CONCLUSÕES: o escore CRIB foi bom preditor do óbito quando aplicado em todos os RN.OBJECTIVES: to evaluate the CRIB (Clinical Risk Index for Babies score as mortality predictor in all newborn at Neonatal Intensive Care Unit (NICU and to compare with birthweight and gestational age. METHODS: observational study with newborn admitted at NICU of University Hospital of Taubaté. The variables were CRIB score, birth weight, gestational age, use of surfactant, umbilical catheter, neonatal asphyxia and death. The association between CRIB score and other variables was estimated. The values of sensitivity, specificity, predictive and negative values and relative risk and 95% confidence interval of were estimated and created ROC (Receiver Operating

  6. Chemical Composition and Biological Activities of the Essential Oils from <em>Duguetia lanceolataem> St. Hil. Barks

    Kaplan, Maria A. C.; Rodarte, Mírian P.; Maria P. H. Amaral; Araújo, Aílson A. L.; Míriam A. O. Pinto; Maria S. Alves; Glauciemar Del-Vechio-Vieira; Orlando V. Sousa

    2012-01-01

    Essential oils of <em>Duguetia lanceolataem> barks, obtained at 2 (T2) and 4 h (T4), were identified by gas chromatography and gas chromatography/mass spectrometry. β-Elemene (12.7 and 14.9%), caryophyllene oxide (12.4 and 10.7%) and β-selinene (8.4 and 10.4%) were the most abundant components in T2 and T4, respectively. The essential oils inhibited the growth of <em>Staphylococcus aureusem>,> Streptococcus pyogenesem>, <em>Escherichia coli&l...

  7. Scoring of synovial membrane hypertrophy and bone erosions by MR imaging in clinically active and inactive rheumatoid arthritis of the wrist

    Østergaard, Mikkel; Gideon, P; Sørensen, K;

    1995-01-01

    MRI-scores of synovial membrane hypertrophy and bone erosions of the RA-wrist are introduced. Gadolinium-DTPA enhanced magnetic resonance imaging (MRI) and conventional radiography (CR) of the wrist were performed in 16 patients with rheumatoid arthritis (RA) and 3 healthy controls. A MRI-score of...... MRI and CR with respect to bone erosions. Bone erosions were detected by MRI in 14 wrists in contrast to only 6 wrists by CR. In all patients the erosions were more numerous on MRI. The introduced methods may be useful quantitative measures of synovitis and early joint destruction in RA....... synovial membrane hypertrophy was obtained by summation of gradings of synovial hypertrophy in 6 regions of the wrist. The score was significantly higher in wrists with than in wrists without clinical signs of active arthritis. The score was 0 in all healthy controls. Each bone of the wrist was assessed by...

  8. Activated TLR signaling in atherosclerosis among women with lower Framingham risk score: the multi-ethnic study of atherosclerosis.

    Chiang-Ching Huang

    Full Text Available BACKGROUND: Atherosclerosis is the leading cause of cardiovascular disease (CVD. Traditional risk factors can be used to identify individuals at high risk for developing CVD and are generally associated with the extent of atherosclerosis; however, substantial numbers of individuals at low or intermediate risk still develop atherosclerosis. RESULTS: A case-control study was performed using microarray gene expression profiling of peripheral blood from 119 healthy women in the Multi-Ethnic Study of Atherosclerosis cohort aged 50 or above. All participants had low (100 and carotid intima-media thickness (IMT >1.0 mm, whereas controls (N = 71 had CAC<10 and IMT <0.65 mm. We identified two major expression profiles significantly associated with significant atherosclerosis (odds ratio 4.85; P<0.001; among those with Framingham risk score <10%, the odds ratio was 5.30 (P<0.001. Ontology analysis of the gene signature reveals activation of a major innate immune pathway, toll-like receptors and IL-1R signaling, in individuals with significant atherosclerosis. CONCLUSION: Gene expression profiles of peripheral blood may be a useful tool to identify individuals with significant burden of atherosclerosis, even among those with low predicted risk by clinical factors. Furthermore, our data suggest an intimate connection between atherosclerosis and the innate immune system and inflammation via TLR signaling in lower risk individuals.

  9. Atividade de glutationa S-transferase na metabolização de acetochlor, atrazine e oxyfluorfen em milho (<em>Zea maysem> L.), sorgo (<em>Sorghum bicolorem> L.) e trigo (<em>Triticum aestivumem> L.) (Poaceae) Glutathione S-transferase activity in acetochlor, atrazine and oxyfluorfen metabolization in maize (<em>Zea maysem> L.), sorghum (<em>Sorghum bicolorem> L.) and wheat (<em>Triticum aestivumem>L.) (Poaceae)

    Ethel Lourenzi Barbosa Novelli; José Claudionir Carvalho; Guilherme Fernando Gomes Déstro; Karina Luiz Chamma; Leonardo César Ferreira; Ana Catarina Cataneo

    2002-01-01

    Este experimento foi conduzido para avaliar a seletividade em plantas dos herbicidas acetochlor, atrazine e oxyfluorfen em relação à atividade da glutationa S-transferase (GST) em plantas de milho (Zea mays L.), sorgo (Sorghum bicolor L.) e trigo (Triticum aestivum L.) (Poaceae). A atividade da GST foi detectada às 24, 48 e 72 horas após as aplicaç��es dos tratamentos. Os tratamentos do experimento consistiram de aplicação com água (controle), acetochlor (3 L.ha-1), atrazine (4 L.ha-1) e oxyf...

  10. Validity and Agreement between the 28-Joint Disease Activity Score Based on C-Reactive Protein and Erythrocyte Sedimentation Rate in Patients with Rheumatoid Arthritis

    Nielung, Louise; Christensen, Robin; Danneskiold-Samsøe, Bente;

    2015-01-01

    Objective. To validate the agreement between the 28-joint disease activity score based on erythrocyte sedimentation rate (DAS28-ESR) and the 28-joint disease activity score based on C-reactive protein (DAS28-CRP) in a group of Danish patients with rheumatoid arthritis (RA). Methods. Data from 109...... Danish RA patients initiating biologic treatment were analysed at baseline and following one year of treatment. Participants were retrospectively enrolled from a previous cohort study and were considered eligible for this project if CRP and ESR were measured at baseline and at the follow-up visit. To...

  11. Leishmanicidal, antiplasmodial and cytotoxic activity of indole alkaloids from <em>Corynanthe pachycerasem>

    Staerk, D; Lemmich, E; Christensen, J;

    2000-01-01

    -NMR resonances by COSY and NOESY experiments. These and related alkaloids showed pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquine-sensitive Plasmodium falciparum). Cytotoxicity assessed with drug...

  12. Anti-Oxidative, Anti-Tumor-Promoting, and<em> em>Anti-Carcinogensis Activities of Nitroastaxanthin and Nitrolutein, the Reaction Products of Astaxanthin and Lutein with Peroxynitrite

    Hideo Etoh

    2012-06-01

    Full Text Available Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin showed excellent singlet oxygen quenching activity. Furthermore, 15-nitroastaxanthin showed inhibitory effects of <em>in vitroem> Epstein-Barr virus early antigen activation and two-stage carcinogensis on mouse skin papillomas. These activities were slightly higher than those of astaxanthin. Similar results were obtained for the 15-nitrolutein, a major reaction product of lutein with peroxynitrite.

  13. Reduced Photoinhibition under Low Irradiance Enhanced Kacip Fatimah (<em>Labisia pumila em>Benth Secondary Metabolites, Phenyl Alanine Lyase and Antioxidant Activity

    Hawa Z.E. Jaafar

    2012-04-01

    Full Text Available A randomized complete block design experiment was designed to characterize the relationship between production of total flavonoids and phenolics, anthocyanin, photosynthesis, maximum efficiency of photosystem II (Fv/Fm, electron transfer rate (Fm/Fo, phenyl alanine lyase activity (PAL and antioxidant (DPPH in <em>Labisia pumilaem> var. <em>alata,> em>under four levels of irradiance (225, 500, 625 and 900 µmol/m2/s for 16 weeks. As irradiance levels increased from 225 to 900 µmol/m2/s, the production of plant secondary metabolites (total flavonoids, phenolics and antocyanin was found to decrease steadily. Production of total flavonoids and phenolics reached their peaks under 225 followed by 500, 625 and 900 µmol/m2/s irradiances. Significant positive correlation of production of total phenolics, flavonoids and antocyanin content with Fv/Fm, Fm/Fo and photosynthesis indicated up-regulation of carbon-based secondary metabolites (CBSM under reduced photoinhibition on the under low light levels condition. At the lowest irradiance levels, <em>Labisia pumilaem> extracts also exhibited a significantly higher antioxidant activity (DPPH than under high irradiance. The improved antioxidative activity under low light levels might be due to high availability of total flavonoids, phenolics and anthocyanin content in the plant extract. It was also found that an increase in the production of CBSM was due to high PAL activity under low light, probably signifying more availability of phenylalanine (Phe under this condition.

  14. Nutritional Quality of Breakfast and Physical Activity Independently Predict the Literacy and Numeracy Scores of Children after Adjusting for Socioeconomic Status

    O'Dea, Jennifer A.; Mugridge, Anna C.

    2012-01-01

    Health-related behaviors [physical activity (PA), nutritional quality of breakfast and sleep]; personal variables (self-esteem, attitudes to PA and gender) and socioeconomic status (SES) (school SES and parental education), were examined in relation to literacy and numeracy scores of 824 grade 3-7 children. Participants completed a questionnaire,…

  15. Quality assurance guidance for laboratory assessment plates in support of EM environmental sampling and analysis activities

    This document is one of several guidance documents developed to support the EM (DOE Environmental Restoration and Waste Management) Analytical Services program. Its purpose is to introduce assessment plates that can be used to conduct performance assessments of an organization's or project's ability to meet quality goals for analytical laboratory activities. These assessment plates are provided as non-prescriptive guidance to EM-support organizations responsible for collection of environmental data for remediation and waste management programs at DOE facilities. The assessments evaluate objectively all components of the analytical laboratory process to determine their proper selection and use

  16. Enhancement of human natural cytotoxicity by <em>Plasmodium falciparumem> antigen activated lymphocytes

    Theander, T G; Pedersen, B K; Bygbjerg, I C;

    1987-01-01

    Mononuclear cells (MNC) isolated from malaria immune donors and from donors never exposed to malaria were stimulated in vitro with soluble purified Plasmodium falciparum antigens (SPag) or PPD. After 7 days of culture the proliferative response and the cytotoxic activity against the natural killer...

  17. Evaluation of Antioxidant and Antiproliferative Properties of Three <em>Actinidia> (<em>Actinidia> <em>kolomikta>, <em>Actinidia argutaem>, <em>Actinidia> <em>chinensis> Extracts <em>in Vitroem>

    Jia-Ren Liu

    2012-05-01

    Full Text Available The total phenolic content, total flavonoid content, vitamin C content, and antioxidant activities of ethanol extracts from different kiwifruit varieties (<em>Actinidia> <em>kolomikta>, <em>Actinidia argutaem>, <em>Actinidia> <em>chinensis> were determined in this study. Multiple scavenging activity assays including the hydroxyl radical, O2·radical, DPPH, and the ABTS+ radical scavenging activity assays were used to identify the antioxidant activities of <em>Actinidia> extracts. The cell viability of HepG2 and HT-29 cells was also examined in this study. The results demonstrated that the <em>Actinidia kolomiktaem> extract had a higher antioxidant activity than the other two <em>Actinidia> extracts. There is a positive correlation between antioxidant activity and the polyphenols and vitamin C content in all three extracts (<em>R>2 ≥ 0.712, <em>p> em>< 0.05. The <em>Actinidia argutaem> extract had the highest inhibitory effect on HepG2 and HT-29 cell growth. These results provide new insight into the health functions of fruit and demonstrate that <em>Actinidia> extracts can potentially have health benefits.

  18. Variation in dietary intake and physical activity pattern as predictors of change in body mass index (BMI) Z-score among Brazilian adolescents*

    Carla C. Enes; Betzabeth Slater

    2013-01-01

    Objective: To assess whether changes in dietary intake and physical activity pattern are associated with the annual body mass index (BMI) z-score change among adolescents. Methods: The study was conducted in public schools in the city of Piracicaba, Sao Paulo, Brazil, with a probabilistic sample of 431 adolescents participating in wave I (2004) (hereafter, baseline) and 299 in wave II (2005) (hereafter, follow-up). BMI, usual food intake, physical activity, screen time, sexual maturation and ...

  19. Handedness and behavioural inhibition system/behavioural activation system (BIS/BAS) scores: A replication and extension of Wright, Hardie, and Wilson (2009).

    Beaton, Alan A; Kaack, Imogen H; Corr, Philip J

    2015-01-01

    The Annett Hand Preference Questionnaire (AHPQ) as modified by Briggs and Nebes was administered along with Carver and White's behavioural inhibition system (BIS) and behavioural activation system (BAS) scale and a shortened form of the Big Five personality questionnaire to 92 university students. After eliminating the data from five respondents who reported having changed handedness and one outlier, there was a significant sex difference in mean BIS scores, with females (n = 43) scoring higher than males (n = 43). Replicating the results of Wright, Hardie and Wilson, non-right-handers (n = 36) had significantly higher mean BIS score than right-handers (n = 50). Controlling for sex of participant, neuroticism and BAS sub-scale scores in hierarchical regression analyses left this BIS effect substantially unaffected. There was no handedness or sex difference on any of the three BAS sub-scales. Further analyses revealed no association between strength, as distinct from direction, of handedness and BIS (or BAS) scores. The findings are discussed with reference to recent developments in reinforcement sensitivity theory on which BIS/BAS variables are based. PMID:25697855

  20. Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from <em>Morinda lucidaem>

    Sittie, A A; Lemmich, E; Olsen, C E;

    1999-01-01

    Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Lei...

  1. MAO-A inhibitory activity of quercetin from <em>Calluna vulgaris em>(L.) Hull

    Saaby, Lasse; Rasmussen, Hasse Bonde; Jäger, Anna Katharina

    2009-01-01

    water. The three fractions were tested in a photometric peroxidase linked MAO-A bioassay. The ethyl acetate phase showed the highest MAO-A inhibitory activity. Quercetin was isolated by VLC through bioassay-guided fractionation and purified by re-crystallisation. The structure was elucidated by LC......-MS and (1)H NMR. RESULTS: The IC(50)-value for MAO-A inhibition by quercetin was 18+/-0.2muM in an assay where the IC(50)-value for MAO-A inhibition by clorgylin was 0.2+/-0.02muM. CONCLUSION: The content of quercetin in Calluna vulgaris might explain the reported nerve calming effect of the plant....

  2. Antioxidant activity and phenylpropanoids of <em>Phlomis lychnitisem> L

    López, Víctor; Jäger, Anna Katharina; Akerreta, Silvia;

    2010-01-01

    Phlomis lychnitis L. (Lamiaceae) is consumed as a traditional herbal tea in Spain. The antioxidant-protective effects as well as its phytoconstituents have never been established. The ability of the methanolic extract to protect cells from oxidative stress was evaluated in rat pheochromocytoma...... cells (PC12) using hydrogen peroxide as toxic agent. The viability of PC12 cells pre-treated with the methanolic extract of Phlomis lychnitis, determined by the MTT and LDH assays, was significantly improved at the highest dose (p < 0.01). The antioxidant activity was confirmed evaluating the capacity...... of the plant to scavenge ABTS, DPPH, O(2) . (-) radicals and to inhibit XO. Bioassay guided fractionation led to antioxidant compounds. Qualitative HPLC/DAD/ESI/MS analysis reported phenylpropanoids, verbascoside being the major antioxidant constituent....

  3. Orbital magnetic resonance imaging combined with clinical activity score can improve the sensitivity of detection of disease activity and prediction of response to immunosuppressive therapy for Graves' ophthalmopathy

    The aim of this study was to demonstrate that the addition of orbital magnetic resonance (MR) imaging can provide improvement in sensitivity of detection of active disease and the prediction of the response to intravenous glucocorticoid therapy (ivGC), over clinical activity score (CAS) alone. A prospective case series was studied at our institution. Forty eight patients were examined by CAS and orbital MR imaging. The maximum of T2 relaxation times of extraocular muscles (maxT2RT) and other parameters were evaluated by MR imaging. Thirty five of 48 patients underwent ivGC. Twenty of 35 patients, whose CAS was 2 points or less, were evaluated for the response to ivGC. The correlation between CAS and maxT2RT was evaluated. Differentiation of active and inactive Graves' ophthalmopathy (GO) was performed by CAS and orbital MR imaging. The response to ivGC was evaluated by CAS, orbital MR imaging and ophthalmic parameters. As a result, CAS and maxT2RT showed significant positive correlation (r=0.58, p<0.0001), and 15 patients were positive by CAS and orbital MR imaging. However, 20 patients were positive by only MR imaging. In those 20 patients, there was significant improvement after ivGC. We concluded that orbital MR imaging combined with CAS could improve the sensitivity of detection of active disease and the prediction of the response to ivGC. In addition, even if only one parameter of CAS is positive, further examination with orbital MR imaging is advised. (author)

  4. Phytochemical and Biological Studies of <em>Agave em>attenuata>

    Vincenzo De Feo; Muhammad Riaz; Nasir Rasool; Muhammad Zubair; Komal Rizwan; Muhammad Zia-Ul-Haq

    2012-01-01

    The present study was conducted to examine various biological activities of a methanol extract of <em>Agave attenuataem> leaves. GC-MS analysis of the <em>n>-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), <em>n>-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable levels of total phenolic contents (10...

  5. Activation tagging of the two closely linked genes <em>LEP em>and <em>VAS em>independently affects vascular cell number

    van der Graaff, Eric; Hooykaas, Paul J J; Keller, Beat

    2002-01-01

    report that in addition to this leafy petiole phenotype, the size of the vascular bundles is increased in all aerial organs in let as a result of an increase in the number of xylem, phloem (pro)cambial and pericycle cells. This vascular phenotype is caused by activation tagging of the two genes VASCULAR......-promoting factor. The activation tagging of VAS only resulted in a specific increase in phloem (pro)cambial and pericycle cells. We conclude that activation tagging of LEP and VAS results in additive phenotypes. Insertional mutants for LEP and VAS display wild-type vascular development, indicating the relevance of...... activation tagging for functional analysis of novel genes involved in plant development....

  6. Endoproteolytic activities in pea roots inoculated with the arbuscular mycorrhizal fungus <em>Glomus mosseae em>and/or>Aphanomyces euteiches em>in relation to bioprotection

    Slezack, S; DUMAS-GAUDOT, E; Rosendahl, Søren; Kjøller, Rasmus; Paynot, M; Negrel, J; Gianinazzi, S

    1999-01-01

    Arbuscular mycorrhizal (AM) symbioses are known to play a role in increased resistance of plants against soilborne pathogens. Mechanisms involved in this phenomenon are not yet well understood. This work investigates possible roles of endoproteolytic activities in bioprotection of Pisum sativum...... roots by Glomus mosseae against Aphanomyces euteiches. First, it is demonstrated that bioprotection occurs only in pre-mycorrhizal plants. Second, endoproteolytic activities were analysed qualitatively and quantitatively during AM symbiosis, in plants infected with either zoospores or mycelium of A....... euteiches, and in mycorrhizal plants infected with the pathogen. In mycorrhizal symbiosis a progressive increase in endoproteolytic activities was observed following root colonization by G. mosseae. By contrast, in roots inoculated with A. euteiches, a drastic increase in endoproteolytic activities was...

  7. Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic <em>Lycopodium annotinumem> ssp. <em>alpestre>

    Halldórsdóttir, Elsa Steinunn; Jaroszewski, Jerzy W; Olafsdottir, Elin Soffia

    The aim of this study was to investigate structures and acetylcholinesterase inhibitory activities of lycopodane-type alkaloids isolated from an Icelandic collection of Lycopodium annotinum ssp. alpestre. Ten alkaloids were isolated, including annotinine, annotine, lycodoline, lycoposerramine M...... determined. Conformation of acrifoline was characterized using NOESY spectroscopy and molecular modelling. The isolated alkaloids were evaluated for their in vitro inhibitory activity against acetylcholinesterase and butyrylcholinesterase. Ligand docking studies based on mutated 3D structure of Torpedo...... californica acetylcholinesterase provided rationale for low inhibitory activity of the isolated alkaloids as compared to huperzine A or B, which are potent acetylcholinesterase inhibitors belonging to the lycodine class. Based on the modelling studies the lycopodane-type alkaloids seem to fit well into the...

  8. The relationship between the acoustic behaviour and surface activity of killer whales (<em>Orcinus orcaem>) that feed on herring (<em>Clupea harengusem>)

    Simon, Malene Juul; McGregor, Peter K.; Ugarte, Fernando

    2007-01-01

    We describe the acoustic behaviour of piscivorous killer whales in Norwegian and Icelandic waters. Whales were assigned to one of three activities (feeding, travelling or other), and sound recordings were made in their proximity with a single hydrophone and a digital audiotape (DAT) recorder. A...... quantitative analysis of the production of pulsed calls, whistles and echolocation clicks in the three activities revealed that there was a significant effect of activity on the production of these sound types. Both killer whales in Icelandic and Norwegian waters produced high rates of clicks and calls during...... feeding and low rates of click, calls and whistles during travelling. The differences can be used as acoustical markers and provides new possibilities for acoustic monitoring of killer whales in these areas. Based on the similarity between their prey choice, hunting strategies, phenotype and acoustic...

  9. The relationship between the acoustic behaviour and surface activity of killer whales (<em>Orcinus orcaem>) that feed on herring (<em>Clupea harengusem>)

    Simon, M.; McGregor, P.K.; Ugarte, F.

    2007-01-01

    quantitative analysis of the production of pulsed calls, whistles and echolocation clicks in the three activities revealed that there was a significant effect of activity on the production of these sound types. Both killer whales in Icelandic and Norwegian waters produced high rates of clicks and calls during......We describe the acoustic behaviour of piscivorous killer whales in Norwegian and Icelandic waters. Whales were assigned to one of three activities (feeding, travelling or other), and sound recordings were made in their proximity with a single hydrophone and a digital audiotape (DAT) recorder. A...... feeding and low rates of click, calls and whistles during travelling. The differences can be used as acoustical markers and provides new possibilities for acoustic monitoring of killer whales in these areas. Based on the similarity between their prey choice, hunting strategies, phenotype and acoustic...

  10. Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study

    Heshmat, Ramin; shafiee, Gita; Kelishadi, Roya; Babaki, Amir Eslami Shahr; Motlagh, Mohammad Esmaeil; Arefirad, Tahereh; Ardalan, Gelayol; Ataie-Jafari, Asal; Asayesh, Hamid; Mohammadi, Rasool

    2015-01-01

    BACKGROUND/OBJECTIVES Although the association of body mass index (BMI) with metabolic syndrome (MetS) is well documented, there is little knowledge on the independent and joint associations of BMI and physical activity with MetS risk based on a continuous scoring system. This study was designed to explore the effect of physical activity on interactions between excess body weight and continuous metabolic syndrome (cMetS) in a nationwide survey of Iranian children and adolescents. SUBJECTS/METHODS Data on 5,625 school students between 10 and 18 years of age were analyzed. BMI percentiles, screen time activity (STA), leisure time physical activity (LTPA) levels, and components of cMetS risk score were extracted. Standardized residuals (z-scores) were calculated for MetS components. Linear regression models were used to study the interactions between different combinations of cMetS, LTPA, and BMI percentiles. RESULTS Overall, 984 (17.5%) subjects were underweight, whereas 501 (8.9%) and 451 (8%) participants were overweight and obese, respectively. All standardized values for cMetS components, except fasting blood glucose level, were directly correlated with BMI percentiles in all models (P-trend < 0.001); these associations were independent of STA and LTPA levels. Linear associations were also observed among LTPA and standardized residuals for blood pressure, high-density lipoprotein, and waist circumference (P-trend < 0.01). CONCLUSIONS Our findings suggest that BMI percentiles are associated with cMetS risk score independent of LTPA and STA levels. PMID:26244080

  11. <em>In vitro em>activity on human gut bacteria of murta leaf extracts (<em>Ugni molinae Turcz. em>), a native plant from southern chile

    Shene, C.; Canquil, N.; Jorquera, M.;

    2012-01-01

    Despite the fact that murta infusions have been used to treat gut/urinary infections by native Chileans for centuries, the mechanisms promoting such effects still remain unclear. As a first attempt to unravel these mechanisms, human fecal samples were incubated in a medium containing water extract...... extracts was significantly (P <0.05) lower than that of penicillin (10 U), whereas the difference between activity of ML extracts and gentamicin (10 μg) was not significant (P > 0.05). No evidence of dependency between the antimicrobial activity of ML extracts and the enzymatic capability of the sensitive...

  12. Evaluation of Pseudopteroxazole and Pseudopterosin Derivatives against <em>Mycobacterium> <em>tuberculosis> and Other Pathogens

    Malcolm W. B. McCulloch

    2012-08-01

    Full Text Available Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin congeners along with simple synthetic mimics of the terpene skeleton were synthesized. In order to build structure-activity relationships, a set of 29 new and previously reported compounds was assessed for <em>in> <em>vitro> antimicrobial and cytotoxic activities. A number of congeners exhibited antimicrobial activity against a range of Gram-positive bacteria including <em>Mycobacterium> <em>tuberculosis> H37Rv, with four displaying notable antitubercular activity against both replicating and non-replicating persistent forms of <em>M.> <em>tuberculosis>. One new semi-synthetic compound, 21-((1<em>H>-imidazol-5-ylmethyl-pseudopteroxazole (7a, was more potent than the natural products pseudopterosin and pseudopteroxazole and exhibited equipotent activity against both replicating and non-replicating persistent forms of <em>M.> <em>tuberculosis> with a near absence of <em>in> <em>vitro> cytotoxicity. Pseudopteroxazole also exhibited activity against strains of <em>M.> <em>tuberculosis> H37Rv resistant to six clinically used antibiotics.

  13. Escore de cálcio na avaliação da aterosclerose em pacientes com HIV/AIDS Calcium score in the evaluation of atherosclerosis in patients with HIV/Aids

    Verônica Soares Monteiro

    2011-11-01

    Full Text Available FUNDAMENTO: A terapia antirretroviral aumentou drasticamente a expectativa de vida em pacientes com HIV/AIDS, embora a aterosclerose esteja associada a uma terapia de longo prazo. OBJETIVO: Investigar a prevalência de aterosclerose em pacientes com AIDS submetidos à terapia antirretroviral e a influência de tratamentos de diferentes regimes e durações. MÉTODOS: Pacientes com HIV/AIDS foram abordados durante consultas de rotina. Aqueles que estiveram em terapia antirretroviral por, pelo menos, dois anos tiveram o sangue coletado para análise do perfil lipídico e da glicemia em jejum e foram submetidos à tomografia computadorizada cardíaca para quantificação do escore de cálcio dentro de seis dias, no máximo. A aterosclerose foi definida como escore de cálcio maior que zero (CAC > 0. Fatores de risco tradicionais, síndrome metabólica e o escore de Framingham foram analisados. RESULTADOS: Cinquenta e três pacientes realizaram tomografia computadorizada cardíaca: 50,94% eram do sexo masculino, com idade média de 43,4 anos; 20% tinham hipertensão; 3,77% tinham diabetes; 67,92% tinham hipercolesterolemia; 37,74% tinham hipertrigliceridemia; 47,17% tinham HDL baixo; 24,53% atenderam aos critérios para síndrome metabólica; 96,23% foram classificados no escore de Framingham como "baixo risco"; e 18,87% eram tabagistas. A duração média do tratamento antirretroviral foi de 58,98 meses. A aterosclerose coronária ocorreu em 11 pacientes (20,75%. A duração da terapia antirretroviral não se relacionou à aterosclerose (p = 0,41, e não houve diferenças significativas entre os diferentes esquemas antirretrovirais (p = 0,71. Entre os fatores de risco tradicionais, o tabagismo (OR = 27,20; p = 0,023 e a idade (OR = 20,59; p = 0,033 foram significativos na presença de aterosclerose. Havia tendência para uma associação positiva da aterosclerose com a hipercolesterolemia (OR = 8,30; p = 0,0668. CONCLUSÃO: Os fatores associados

  14. Activation tagging of the <em>LEAFY PETIOLEem> gene affects leaf petiole development in <em>Arabidopsis thalianaem>

    van der Graaff, Eric; Dulk-Ras, A D; Hooykaas, P J;

    2000-01-01

    In a screen for leaf developmental mutants we have isolated an activator T-DNA-tagged mutant that produces leaves without a petiole. In addition to that leafy petiole phenotype this lettuce (let) mutant shows aberrant inflorescence branching and silique shape. The LEAFY PETIOLE (LEP) gene is...... located close to the right border of the T-DNA insert linked with these dominant phenotypes and encodes a protein with a domain with similarity to the DNA binding domain of members of the AP2/EREBP family of transcription factors. Introduction of the activation-tagged LEP gene in wild-type plants...... conferred all the phenotypic aberrations mentioned above. The leafy petiole phenotype consists of a conversion of the proximal part of the leaf from petiole into leaf blade, which means that leaf development in let is disturbed along the proximodistal axis. Therefore, LEP is involved in either cell division...

  15. The Evolution of the EM Distribution in the Core of an Active Region

    Del Zanna, Giulio; Mason, Helen; Subramanian, Srividya; O'Dwyer, Brendan

    2014-01-01

    We study the spatial distribution and evolution of the slope of the Emission Measure between 1 and 3~MK in the core active region NOAA~11193, first when it appeared near the central meridian and then again when it re-appeared after a solar rotation. We use observations recorded by the Extreme-ultraviolet Imaging Spectrometer (EIS) aboard Hinode, with a new radiometric calibration. We also use observations from the Atmospheric Imaging Assembly (AIA) aboard Solar Dynamics Observatory (SDO). We present the first spatially resolved maps of the EM slope in the 1--3~MK range within the core of the AR using several methods, both approximate and from the Differential Emission Measure (DEM). A significant variation of the slope is found at different spatial locations within the active region. We selected two regions that were not affected too much by any line-of-sight lower temperature emission. We found that the EM had a power law of the form EM~$\\propto T^{b}$, with b = 4.4$\\pm0.4$, and 4.6$\\pm0.4$, during the first...

  16. Live <em>Streptococcus pneumoniaeem>, <em>Haemophilus influenzaeem>, and <em>Neisseria meningitidisem> activate the inflammatory response trhough Toll-like receptors 2, 4, and 9 in species-specific patterns

    Mogensen, T.H.; Paludan, Søren Riis; Kilian, Mogens;

    2006-01-01

    activation by live bacteria. Here, we demonstrate that live Streptococcus pneumoniae, Haemophilus influenzae type b, and Neisseria meningitidis, the three principal causes of bacterial meningitis, use distinct sets of TLRs to trigger the inflammatory response. Using human embryonic kidney 293 cell lines....... meningitidis in cells expressing TLR2, -4, or -9. It is interesting that the ability of S. pneumoniae and N. meningitidis to activate TLR9 was severely attenuated when bacteria had been heat-inactivated prior to stimulation of the cells. In human peripheral blood mononuclear cells, we blocked TLR2, -4, or -9...... infection with live pathogens may lead to activation of PRR not targeted by inactivated bacteria....

  17. POSSUM escore como preditor de mortalidade em pacientes cirúrgicos Utilizacion del puntaje POSSUM como indicador de la mortalidad en pacientes quirúrgicos POSSUM scoring system for predicting mortality in surgical patients

    Adriana Cristina Galbiatti Parminondi Elias

    2009-03-01

    Full Text Available O estudo avaliou a utilização do escore POSSUM (Physiological and Operative Severity Score for Enumeration of Mortality and Morbidity para predizer a mortalidade na prática cirúrgica.Foram analisados 416 pacientes cirúrgicos com internação na UTI para cuidados de pós-operatório. Foram realizadas comparações entre as taxas de mortalidade predita e observada de acordo com 4 grupos de risco: 0-4%, 5-14%, 15-49%, 50% ou mais, e calculada a área sob a curva ROC do escore POSSUM e APACHE II para a mortalidade. A taxa de mortalidade foi de 22,4%. O escores POSSUM e APACHE II superestimaram o risco de morte, e a área sob a curva ROC do POSSUM foi de 0,762 e a do APACHE II de 0,737, sugerindo a utilização do POSSUM como ferramenta auxiliar na predição de risco de morte em pacientes cirúrgicos.El estudio evaluó la utilización del puntaje POSSUM (Physiological and Operative Severity Score for Enumeration of Mortality and Morbity para predecir la mortalidad en la práctica quirúrgica. Fueron analizados 416 pacientes quirúrgicos internados en la UTI para cuidados postoperatorios. Fueron realizadas comparaciones entre las tasas de mortalidad estimada y observada, de acuerdo con 4 grupos de riesgo: 0-4%, 5-14%, 15-49%, 50% o más, y calculada el área debajo de la curva ROC del puntaje POSSUM y APACHE II para la mortalidad. La tasa de mortalidad fue de 2,4%. Los puntajes POSSUM y APACHE II superestimaron el riesgo de muerte, y el área debajo de la curva ROC del POSSUM fue de 0,762 y la del APACHE II de 0,737, lo que sugiere la utilización del POSSUM como herramienta auxiliar en la predicción de riesgo de muerte en pacientes quirúrgicos.This study evaluated the use of the POSSUM (Physiological and Operative Severity Score for Enumeration of Mortality and Morbidity score for predicting mortality in surgical practice. In this study, 416 surgical patients admitted into ICUs for post-surgical care were analyzed. Both predicted and actual

  18. Litter Control Achievement - Ohio 4-H Club Score Sheet [and] Activity Guides 1 through 7. 4-H Pilot Program 918.

    Ohio State Univ., Columbus. Cooperative Extension Service.

    Seven activity guides, evaluation sheet, and club scoresheet have been prepared for Ohio 4-H clubs' litter education program. Topics of the seven activity guides include: (1) general guidelines and types of activities; (2) little known facts about waste/litter; (3) guidelines for a walking tour; (4) fact sheet (questionnaire) related to garbage;…

  19. Low bone mineral density in COPD patients with osteoporosis is related to low daily physical activity and high COPD assessment test scores

    Liu WT

    2015-09-01

    Full Text Available Wen-Te Liu,1,2,* Han-Pin Kuo,3,* Tien-Hua Liao,4 Ling-Ling Chiang,1 Li-Fei Chen,3 Min-Fang Hsu,5 Hsiao-Chi Chuang,1 Kang-Yun Lee,2,6 Chien-Da Huang,3 Shu-Chuan Ho11School of Respiratory Therapy, College of Medicine, Taipei Medical University, 2Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, 3Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 4Department of Respiratory Therapy, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, 5Department of Healthcare Administration, Asia University, Wufeng, Taichung, 6Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan*These authors contributed equally to this workAbstract: COPD patients have an increased prevalence of osteoporosis (OP compared with healthy people. Physical inactivity in COPD patients is a crucial risk factor for OP; the COPD assessment test (CAT is the newest assessment tool for the health status and daily activities of COPD patients. This study investigated the relationship among daily physical activity (DPA, CAT scores, and bone mineral density (BMD in COPD patients with or without OP. This study included 30 participants. Ambulatory DPA was measured using actigraphy and oxygen saturation by using a pulse oximeter. BMD was measured using dual-energy X-ray absorptiometry. OP was defined as a T-score (standard deviations from a young, sex-specific reference mean BMD less than or equal to -2.5 SD for the lumbar spine, total hip, and femoral neck. We quantified oxygen desaturation during DPA by using a desaturation index and recorded all DPA, except during sleep. COPD patients with OP had lower DPA and higher CAT scores than those of patients without OP. DPA was significantly positively correlated with (lumbar spine, total hip, and femoral neck BMD (r=0.399, 0.602, 0.438, respectively

  20. Fetal Biophysical Profile Scoring

    H.R. HaghighatKhah

    2009-01-01

    significance. Fetal breathing movements, amniotic fluid volume, and the non-stress test are the most powerful variables. For example, when the biophysical profile score is 2, the perinatal mortality varies between 428/1000 with only fetal movement present to 66/1000 if the non-stress test is reactive and all of the ultrasound parameters are absent (Manning 1990b. Some authors have, therefore, proposed utilization of a modified biophysical profile that incorporates only the non-stress test and amniotic fluid volume (Miller 1996. Although the positive predictive value of these 2 tests is equivalent to a biophysical profile score of 6, the perinatal mortality is still increased over a normal test score of 8 or 10 (Manning 1990b. The false positive rate with the modified biophysical profile score is also substantially higher. "nConclusions: The fetus expresses its well being or compromised status through a number of different biophysical activities that are controlled by different central nervous system centers. The utilization of the biophysical score for antepartum surveillance in high-risk patients has resulted in a reduction in perinatal mortality when compared to historical controls. The appropriate management of the viable fetus with an abnormal biophysical profile score may also decrease long-term neurological morbidity (Manning 1998. "nIt is unlikely that in the future additional variables will be added to the biophysical profile score. However, perhaps the incorporation of the fetal state (i.e., eye movements and Doppler flow studies of specific fetal vessels (umbilical artery, middle cerebral artery, ductus venosus will be incorporated into a complete assessment of the fetal condition "n "nTable 1. Components of the 30 Minute Biophysical Profile Score "nComponent "nDefinition "nFetal movements "n> 3 body or limb movements "nFetal tone "nOne episode of active extension and flexion of the limbs; opening and closing of hand "nFetal breathing movements "n>1 episode of >30

  1. Visual scoring of non-cavitated caries lesions and clinical trial efficiency, testing xylitol in caries active adults

    Brown, JP; Amaechi, BT; Bader, JD; Gilbert, GH; Makhija, SK; Lozano-Pineda, J; Leo, MC; Chuhe, C; Vollmer, WM

    2013-01-01

    Objectives To better understand the effectiveness of xylitol in caries prevention in adults, and to attempt improved clinical trial efficiency. Methods As part of the Xylitol for Adult Caries Trial (X-ACT), non-cavitated and cavitated caries lesions were assessed in subjects who were experiencing the disease. The trial was a test of the effectiveness of 5 grams/day of xylitol, consumed by dissolving in the mouth five 1 gram lozenges spaced across each day, compared with a sucralose placebo. For this analysis, seeking trial efficiency, 538 subjects aged 21–80, with complete data for four dental examinations were selected from the 691 randomized into the three year trial, conducted at three sites. Acceptable inter and intra examiner reliability before and during the trial was quantified using the kappa statistic. Results The mean annualized non-cavitated plus cavitated lesion transition scores in coronal and root surfaces, from sound to carious favoured xylitol over placebo, during the three cumulative periods of 12, 24, and 33 months, but these clinically and statistically non-significant differences declined in magnitude over time. Restricting the present assessment to those subjects with a higher baseline lifetime caries experience showed possible but inconsistent benefit. Conclusions There was no clear and clinically relevant preventive effect of xylitol on caries in adults with adequate fluoride exposure when non-cavitated plus cavitated lesions were assessed. This conformed to the X-ACT trial result assessing cavitated lesions. Including non-cavitated lesion assessment in this full scale, placebo controlled, multi site, randomized, double blinded clinical trial in adults experiencing dental caries, did not achieve added trial efficiency or demonstrate practical benefit of xylitol. Trial Registration ClinicalTrials.Gov NCT00393055 PMID:24205951

  2. Serum interleukin-18 and interleukin-10 levels in systemic lupus erythematosus: correlation with SLEDAI score and disease activity parameters

    Sahar Abou El-Fetouh; Mohammed, Reem Hamdy A.; Hanan S Mohmad Abozaid

    2014-01-01

    Aim The aim of the study was to assess serum levels of interleukin (IL)-18 and IL-10 in systemic lupus erythematosus (SLE) patients and their relationship with disease activity. Patients and methods Thirty patients with SLE and 20 healthy controls were investigated in this study. The serum IL-18 and IL-10 levels were determined using enzyme-linked immunosorbent assay and their correlations with the disease activity were measured using the Systemic Lupus Erythematosus Disease Activi...

  3. Clinical performance of two visual scoring systems in detecting and assessing activity status of occlusal caries in primary teeth

    Braga, M M; Ekstrand, K R; Martignon, S; Imparato, J C P; Ricketts, D N J; Pedersen, Lia Mendes

    2010-01-01

    reproducibility of the indices was calculated (kappa test) and ROC analysis was performed to assess their validity and related parameters were compared using McNemar's test. The association between the indices and with the histological examination was evaluated using Spearman's correlation coefficient (r......(s)). Visual criteria showed excellent reproducibility both regarding severity (NY: 0.94; ICDAS-II: 0.91) and activity (NY: 0.90; LAA: 0.91). The NY and LAA showed good association in caries activity assessment (r(s) = 0.88; 95% CI = 0.86-0.89; p <0.001). Nevertheless, considering only cavitated lesions, this...

  4. <em>α>-Glucosidase Inhibitory Constituents from <em>Acanthopanax senticosusem> Harm Leaves

    Hai-Xue Kuang

    2012-05-01

    Full Text Available A new triterpene glycoside, 3-<em>O-[(α>-L-rhamnopyranosyl(1→2]-[<em>β>-D-glucuronopyranosyl-6-<em>O>-methyl ester]-olean-12-ene-28-olic acid (1 and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5 were isolated from the leaves of <em>Acanthopanax senticosusem> Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities and compound 6 showed significant <em>α>-glucosidase inhibition activity.

  5. Decompositions of Proper Scores

    Bröcker, Jochen

    2008-01-01

    Scoring rules are an important tool for evaluating the performance of probabilistic forecasts. A popular example is the Brier score, which allows for a decomposition into terms related to the sharpness (or information content) and to the reliability of the forecast. This feature renders the Brier score a very intuitive measure of forecast quality. In this paper, it is demonstrated that all strictly proper scoring rules allow for a similar decomposition into reliability and sharpness related terms. This finding underpins the importance of proper scores and yields further credence to the practice of measuring forecast quality by proper scores. Furthermore, the effect of averaging multiple probabilistic forecasts on the score is discussed. It is well known that the Brier score of a mixture of several forecasts is never worse that the average score of the individual forecasts. This property hinges on the convexity of the Brier score, a property not universal among proper scores. Arguably, this phenomenon portends...

  6. A clinically prognostic scoring system for patients receiving highly active antiretroviral therapy: results from the EuroSIDA study

    Lundgren, Jens Dilling; Mocroft, Amanda; Gatell, Jose M; Ledergerber, Bruno; D'Arminio Monforte, Antonella; Hermans, Philippe; Goebel, Frank-Detlef; Blaxhult, Anders; Kirk, Ole; Phillips, Andrew N; NN, NN

    2002-01-01

    The risk of clinical progression for human immunodeficiency virus (HIV)-infected persons receiving treatment with highly active antiretroviral therapy (HAART) is poorly defined. From an inception cohort of 8457 HIV-infected persons, 2027 patients who started HAART during prospective follow-up wer...

  7. Desempenho de seis modelos de predição prognóstica em pacientes críticos que receberam suporte renal extracorpóreo Performance of six prognostic scores in critically ILL patients receiving renal replacement therapy

    Elizabeth R. Maccariello

    2008-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Não existe consenso sobre qual modelo prognóstico deva ser utilizado em pacientes com disfunção renal aguda (DRA. O objetivo deste estudo foi avaliar o desempenho de seis escores de prognóstico em pacientes que necessitaram de suporte renal. MÉTODO: Coorte prospectiva de pacientes internados nas unidades de terapia intensiva (UTI de três hospitais terciários que necessitaram de suporte renal por DRA durante 32 meses. Foram excluídos os pacientes crônicos em programa de diálise ou com BACKGROUND AND OBJECTIVES: There is no consensus about prognostic scores for use in patients with acute kidney injury (AKI. The aim of this study was to evaluate the performance of six prognostic scores in predicting hospital mortality in patients with AKI and need for renal replacement therapy (RRT. METHODS: Prospective cohort of patients admitted to the intensive care units (ICU of three tertiary care hospitals that required RRT for AKI over a 32-month period. Patients with end-stage renal disease and those with ICU stay < 24h were excluded. Data from the first 24h of ICU admission were used to calculate SAPS II and APACHE II scores, and data from the first 24h of RRT were used in the calculation of LOD, ODIN, Liaño and Mehta scores. Discrimination was evaluated using the area under ROC curve (AUROC and calibration using the Hosmer-Lemeshow goodness-of-fit test. The hospital mortality was the end-point of interest. RESULTS: 467 patients were evaluated. Hospital mortality rate was 75%. Mean SAPS II and APACHE II scores were 48.5 ±11.2 and 27.4 ± 6.3 points, and median LOD score was 7 (5-8 points. Except for Mehta score (p = 0.001, calibration was appropriate in all models. However, discrimination was uniformly unsatisfactory; AUROC ranged from 0.60 for ODIN to 0.72 for SAPS II and Mehta scores. In addition, except for Mehta, all models tended to underestimate hospital mortality. CONCLUSIONS: Organ dysfunction, general and

  8. Peroxidase activity in Spondias dulcis = Atividade da peroxidase em Spondias dulcis

    Lúcio Cardozo-Filho

    2010-10-01

    Full Text Available In this study, the best conditions to obtain crude extracts showingPeroxidase activity from Spondia dulcis (caja-mango were evaluated. Fresh fruits (25 g were blended in different sodium phosphate buffer (0.05 to 0.2 M with a pH varying from 3.0 to 9.0. The muddy material was centrifuged for 20 minutes. In order to improve POD activity, the crude extract was submitted to precipitation with ammonium sulfate at 90% saturation. This precipitated was re-suspended in sodium phosphate buffer 0.2 M pH 6.5 and then, optimum pH for activity assay (pH varying from 5.0 to 9.0 and thermal stability (exposure to different temperatures varying from 30 to 75ºC for periods between 0 to 15 minutes were determined. The best conditions for activity assay were in phosphate buffer 0.2 M at pH7.0. The results obtained for thermal inactivation study suggest that the heating at 75ºCfor 15 minutes inactivated 95% of initial POD activity.Foram avaliadas, neste trabalho, algumas condições para a obtenção de extratos brutos com atividade peroxidase de Spondias dulcis (cajá-manga. Frutas frescas (25 g foram trituradas com tampão fosfato de sódio (0,05 a 0,2 M em pHs diferentes (3,0 a 9,0. O material obtido foi centrifugado por 20 min. O extrato bruto foi submetido à precipitação com sulfato de amônio até 90% de saturação. Este precipitado foi ressuspenso em tampão fosfato de sódio 0,2 M pH 6,5 e, assim, o pH ótimo para o ensaio de atividade (pH que varia de 5,0 a 9,0 e a estabilidade térmica (exposição a temperaturas de 30, 60, 65, 70 e 75ºC por um período de 0 a 15 min. deste foram determinados. As melhores condições encontradas para o ensaio de atividade foram em tampão fosfato 0,2 M pH 7,0. Os resultados para a inativação térmica sugerem que o aquecimento a 75ºC por 15 mininativa 95% da atividade de POD inicial.

  9. Escore de cálcio na avaliação da aterosclerose em pacientes com HIV/AIDS Calcium score in the evaluation of atherosclerosis in patients with HIV/Aids

    Verônica Soares Monteiro; Heloisa Ramos Lacerda; Marly Uellendahl; Tien Man Chang; Valéria Maria de Albuquerque; Josefina Cláudia Zirpoli; Ricardo Araes Ximenes; Maria de Fátima Militão de Albuquerque; Demócrito de Barros Miranda Filho; Dário Sobral Filho

    2011-01-01

    FUNDAMENTO: A terapia antirretroviral aumentou drasticamente a expectativa de vida em pacientes com HIV/AIDS, embora a aterosclerose esteja associada a uma terapia de longo prazo. OBJETIVO: Investigar a prevalência de aterosclerose em pacientes com AIDS submetidos à terapia antirretroviral e a influência de tratamentos de diferentes regimes e durações. MÉTODOS: Pacientes com HIV/AIDS foram abordados durante consultas de rotina. Aqueles que estiveram em terapia antirretroviral por, pelo menos,...

  10. The Antimicrobial Efficacy of <em>Elaeis guineensisem>: Characterization, <em>in Vitroem> and <em>in Vivoem> Studies

    Sreenivasan Sasidharan

    2012-04-01

    Full Text Available The urgent need to treat multi-drug resistant pathogenic microorganisms in chronically infected patients has given rise to the development of new antimicrobials from natural resources. We have tested <em>Elaeis guineensis em>Jacq> em>(Arecaceae methanol extract against a variety of bacterial, fungal and yeast strains associated with infections. Our studies have demonstrated that <em>E. guineensisem> exhibits excellent antimicrobial activity <em>in vitroem> and <em>in vivoem> against the bacterial and fungal strains tested. A marked inhibitory effect of the <em>E. guineensisem> extracts was observed against <em>C. albicansem> whereby <em>E. guineensisem> extract at ½, 1, or 2 times the MIC significantly inhibited <em>C. albicansem> growth with a noticeable drop in optical density (OD of the bacterial culture. This finding confirmed the anticandidal activity of the extract on <em>C. albicansem>. Imaging using scanning (SEM and transmission (TEM electron microscopy was done to determine the major alterations in the microstructure of the extract-treated <em>C. albicansem>. The main abnormalities noted via SEM and TEM studies were the alteration in morphology of the yeast cells. <em>In vivoem> antimicrobial activity was studies in mice that had been inoculated with <em>C. albicansem> and exhibited good anticandidal activity. The authors conclude that the extract may be used as a candidate for the development of anticandidal agent.<em> em>

  11. Greater Independence in Activities of Daily Living is Associated with Higher Health-Related Quality of Life Scores in Nursing Home Residents with Dementia

    Charice S. Chan

    2015-06-01

    Full Text Available Health-related quality of life (HRQL for nursing home residents is important, however, the concept of quality of life is broad, encompasses many domains and is difficult to assess in people with dementia. Basic activities of daily living (ADL are measured routinely in nursing homes using the Resident Assessment Instrument-Minimum Data Set Version 2.0 (RAI-MDS and Functional Independence Measure (FIM instrument. We examined the relationship between HRQL and ADL to assess the future possibility of ADL dependency level serving as a surrogate measure of HRQL in residents with dementia. To assess ADL, measures derived from the RAI-MDS and FIM data were gathered for 111 residents at the beginning of our study and at 6-month follow-up. Higher scores for independence in ADL were correlated with higher scores for a disease-specific HRQL measure, the Quality of Life—Alzheimer’s Disease Scale. Preliminary evidence suggests that FIM-assessed ADL is associated with HRQL for these residents. The associations of the dressing and toileting items with HRQL were particularly strong. This finding suggests the importance of ADL function in HRQL. The RAI-MDS ADL scales should be used with caution to evaluate HRQL.

  12. Pharmacological Classification and Activity Evaluation of Furan and Thiophene Amide Derivatives Applying Semi-Empirical <em>ab initioem> Molecular Modeling Methods

    Leszek Bober

    2012-05-01

    Full Text Available Pharmacological and physicochemical classification of the furan and thiophene amide derivatives by multiple regression analysis and partial least square (PLS based on semi-empirical <em>ab initioem> molecular modeling studies and high-performance liquid chromatography (HPLC retention data is proposed. Structural parameters obtained from the PCM (Polarizable Continuum Model method and the literature values of biological activity (antiproliferative for the A431 cells expressed as LD50 of the examined furan and thiophene derivatives was used to search for relationships. It was tested how variable molecular modeling conditions considered together, with or without HPLC retention data, allow evaluation of the structural recognition of furan and thiophene derivatives with respect to their pharmacological properties.

  13. Conclusion on the peer review of the pesticide risk assessment of the active substance [<em>Trichoderma atrovirideem> strain I-1237

    European Food Safety Authority

    2012-10-01

    Full Text Available

    The conclusions of the European Food Safety Authority (EFSA following the peer review of the initial risk assessments carried out by the competent authority of the rapporteur Member State France, for the pesticide active substance <em>Trichoderma atrovirideem> strain I-1237 are reported. The context of the peer review was that required by Commission Regulation (EU No 188/2011. The conclusions were reached on the basis of the evaluation of the representative uses of Trichoderma atroviride strain I-1237 as a fungicide in vineyards and grapevine nursery. The reliable endpoints concluded as being appropriate for use in regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are presented. Missing information identified as being required by the regulatory framework is listed.

  14. Low Diversity Bacterial Community and the Trapping Activity of Metabolites from Cultivable Bacteria Species in the Female Reproductive System of the Oriental Fruit Fly, <em>Bactrocera dorsalisem> Hendel (Diptera: Tephritidae

    Hongyu Zhang

    2012-05-01

    Full Text Available Our goal was to identify the bacteria inhabiting the reproductive system of the female oriental fruit fly, <em>Bactrocera dorsalisem> (Hendel, and evaluate the chemotaxis of <em>B>. <em>dorsalis> to the metabolites produced by the bacteria. Based on 16S rRNA-based polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE, 18 operational taxonomic units (OTUs were assigned to the five bacterial classes <em>Betaproteobacteria>, <em>Alphaproteobacteria>, <em>Gammaproteobacteria>, <em>Bacilli> and <em>Actinobacteria>. Nine OTUs were assigned to <em>Gammaproteobacteria>, which was the most highly represented class. <em>Enterobacteriaceae> constituted the dominant family, and within this family, three genera and five species were identified, including <em>Enterobacter sakazakiiem>, <em>Klebsiella> <em>oxytoca>, <em>Klebsiella> <em>pneumoniae,> Raoultellaem> <em>terrigena em>and <em>Enterobacter> <em>amnigenus>. In this set, the first two species were the dominant components, and the latter three species were the minor ones. Finally, we found that the metabolites produced by <em>R.> terrigenaem>, <em>K. oxytocaem> and <em>K.> pneumoniae em>were attractive to the <em>B.> dorsalisem> adults, and in field studies, <em>B.> dorsalisem> adults were most attracted to <em>K.> oxytocaem>. Collectively, our results suggest that the female reproductive system plays an important role in the transfer of enterobacteria from the gut to fruit. Our data may prompt the development of a female-targeted population control strategy for this fly.

  15. The integrated performance evaluation program quality assurance guidance in support of EM environmental sampling and analysis activities

    EM's (DOE's Environmental Restoration and Waste Management) Integrated Performance Evaluation Program (IPEP) has the purpose of integrating information from existing PE programs with expanded QA activities to develop information about the quality of radiological, mixed waste, and hazardous environmental sample analyses provided by all laboratories supporting EM programs. The guidance addresses the goals of identifying specific PE sample programs and contacts, identifying specific requirements for participation in DOE's internal and external (regulatory) programs, identifying key issues relating to application and interpretation of PE materials for EM headquarters and field office managers, and providing technical guidance covering PE materials for site-specific activities. (PE) Performance Evaluation materials or samples are necessary for the quality assurance/control programs covering environmental data collection

  16. Guidance for establishment and implementation of field sample management programs in support of EM environmental sampling and analysis activities

    The role of the National Sample Management Program (NSMP) proposed by the Department of Energy's Office of Environmental Management (EM) is to be a resource for EM programs and for local Field Sample Management Programs (FSMPs). It will be a source of information on sample analysis and data collection within the DOE complex. The purpose of this document is to establish the suggested scope of the FSMP activities to be performed under each Operations Office, list the drivers under which the program will operate, define terms and list references. This guidance will apply only to EM sampling and analysis activities associated with project planning, contracting, laboratory selection, sample collection, sample transportation, laboratory analysis and data management

  17. Avaliação da aplicabilidade de um modelo de credit scoring com varíaveis sistêmicas e não-sistêmicas em carteiras de crédito bancário rotativo de pessoas físicas An evaluation on the applicability of a credit scoring model, with systemic and non-systemic variables in revolving bank credit portfolio for individuals

    José Odálio dos Santos

    2007-08-01

    Full Text Available As concessões de crédito rotativo às pessoas físicas (cheque especial e cartão de crédito vêm crescendo significativamente nos últimos anos, o que, em parte, é explicado pela relativa estabilização da economia, maior geração de empregos e êxito no controle da inflação - fatores que interferem diretamente na capacidade de pagamento dos tomadores. Paralelamente, observa-se uma maior exposição histórica dos Bancos ao risco de inadimplência, ou seja, o do não-recebimento (parcial ou total de créditos rotativos utilizados pelas pessoas físicas. Considerando o tamanho e a importância desse mercado aos grandes Bancos Comerciais e a economia como um todo, direciona-se essa pesquisa para: 1. detalhar os processos de análise subjetiva e objetiva de crédito realizada pelos principais Bancos privados nacionais; 2. abordar a função seletiva das taxas de juros em créditos rotativos; 3. destacar as principais características dos modelos de credit scoring e 4. propor um modelo de credit scoring para créditos rotativos composto por variáveis sistêmicas e não-sistêmicas, direcionado à redução do risco de inadimplência. A aplicabilidade do modelo proposto de credit scoring em uma amostra extraída da carteira de crédito de pessoas físicas de um importante Banco Comercial privado nacional de médio porte (Banco X - nome fictício, apresentou satisfatório índice de acerto na identificação de clientes prospectivos (96% e não-prospectivos (92%, levando à conclusão de que incluía e ponderava, adequadamente, as variáveis representativas da capacidade de pagamento dos tomadores.The concessions of revolving credit to consumers (guaranteed check and credit card have been growing significantly in the last few years, which is in part explained by the relative stabilization of the economy, higher levels of job creation and success in controlling inflation - factors that have a direct influence in the borrowers’ payment

  18. Efficient Heterologous Transformation of <em>Chlamydomonas> reinhardtiiem> <em>npq2em> Mutant with the Zeaxanthin Epoxidase Gene Isolated and Characterized from<em> Chlorella zofingiensisem>

    Herminia Rodríguez

    2012-09-01

    Full Text Available In the violaxanthin cycle, the violaxanthin de-epoxidase and zeaxanthin epoxidase catalyze the inter-conversion between violaxanthin and zeaxanthin in both plants and green algae. The zeaxanthin epoxidase gene from the green microalga <em>Chlorella zofingiensisem> (<em>Czzep> has been isolated<em>. em>This gene encodes a polypeptide of 596 amino acids. A single copy of <em>Czzep> has been found in the <em>C. zofingiensisem> genome by Southern blot analysis. qPCR analysis has shown that transcript levels of <em>Czzep> were increased after zeaxanthin formation under high light conditions. The functionality of <em>Czzep> gene by heterologous genetic complementation in the <em>Chlamydomonas> mutant <em>npq2em>, which lacks zeaxanthin epoxidase (ZEP activity and accumulates zeaxanthin in all conditions, was analyzed. The <em>Czzep> gene was adequately inserted in the pSI105 vector and expressed in <em>npq2em>. The positive transformants were able to efficiently convert zeaxanthin into violaxanthin, as well as to restore their maximum quantum efficiency of the PSII (Fv/Fm. These results show that <em>Chlamydomonas> can be an efficient tool for heterologous expression and metabolic engineering for biotechnological applications.

  19. Translation, Validation and Cross-Cultural Adaptation of a Simplified-Chinese Version of the Tegner Activity Score in Chinese Patients with Anterior Cruciate Ligament Injury.

    Hongshi Huang

    Full Text Available To translate the English version of Tegner Activity Score into a Simplified-Chinese version (Tegner-C and evaluate its psychometric properties.Tegner-C was cross-culturally adapted according to established guidelines. The validity and reliability of Tegner-C were assessed in 78 participants, with 19-20 participants in each of the four groups: before anterior cruciate ligament reconstruction (pre-ACLR group, 2-3 months after ACLR group, 3-12 months after ACLR group, and healthy control group. Each participant was asked to complete the Tegner-C and Chinese version of International Knee Documentation Committee Subjective Knee Form (IKDC-SKF-C twice, with an interval of 5±2 days. Intra-class correlation coefficient (ICC2, 1 was used to assess the reliability and Spearman's rank correlation was used for construct validity.The ICC2,1 was higher than 0.90 for all groups except in the pre-ACLR group, for which the ICC2,1 was 0.71 (0.41, 0.87 (All with p<0.001. The absolute reliability as evaluated by the smallest detectable change was 0.43, 2.12, 0.89, and 0.44 for the healthy control group, pre-ACLR group, 2-3 months after ACLR group, and 3-12 months after ACLR group, respectively. Neither a ceiling effect nor a floor effect was observed for any group. Significant difference was observed for both Tegner-C and IKDC-SKF-C scores between the control and the other three groups (all with p<0.001, and between pre-ACLR and the 2-3 months after ACLR group (p<0.001.Tegner-C demonstrated comparable psychometric properties to the original English version and thus is reliable and valid for Chinese-speaking patients with ACL injury.

  20. Fingerprinting of music scores

    Irons, Jonathan; Schmucker, Martin

    2004-06-01

    Publishers of sheet music are generally reluctant in distributing their content via the Internet. Although online sheet music distribution's advantages are numerous the potential risk of Intellectual Property Rights (IPR) infringement, e.g. illegal online distributions, disables any innovation propensity. While active protection techniques only deter external risk factors, additional technology is necessary to adequately treat further risk factors. For several media types including music scores watermarking technology has been developed, which ebeds information in data by suitable data modifications. Furthermore, fingerprinting or perceptual hasing methods have been developed and are being applied especially for audio. These methods allow the identification of content without prior modifications. In this article we motivate the development of watermarking and fingerprinting technologies for sheet music. Outgoing from potential limitations of watermarking methods we explain why fingerprinting methods are important for sheet music and address potential applications. Finally we introduce a condept for fingerprinting of sheet music.

  1. Intervenções terapêuticas em Unidade de Terapia Intensiva: análise segundo o Therapeutic Intervention Scoring System-28 (TISS-28 Intervenciones terapéuticas en Unidad de Cuidados Intensivos: análisis según el Therapeutic Intervention Scoring System-28 (TISS-28 Therapeutic interventions in Intensive Care Units: analysis according to Therapeutic Intervention Scoring System-28 (TISS-28

    Paulo Carlos Garcia

    2005-04-01

    Full Text Available O presente estudo teve como objetivos descrever a prevalência diária das categorias de intervenções terapêuticas e identificar a prevalência dos itens componentes de cada categoria de intervenções terapêuticas, segundo o TISS-28. A amostra incluiu 89 admissões consecutivas na UTI geral de um Hospital Universitário do município de São Paulo. Das 7 categorias do TISS-28, houve prevalência na pontuação das categorias Atividades Básicas e Suportes Ventilatório, Cardiovascular e Renal, com freqüência entre 73,0% e 100,0%. A freqüência dos itens componentes da categoria Atividades Básicas foi maior do que 90,0%. O sub-iten medida quantitativa do débito urinário foi pontuado em 98,2% na categoria Suporte Renal. Os resultados obtidos podem imprimir qualidade a assistência prestada aos clientes, na medida em que contribuem para a previsão de recursos humanos e materiais na UTI.El presente estudio tuvo como objectivos, identificar las categorías de intervenciones terapéuticas realizadas en la Unidad de Cuidados Intensivos (UCI y describir la prevalencia diaria de las mismas e identificar los items que la conforman, según el TISS-28. La muestra estuvo constituida por 89 pacientes adultos admitidos consecutivamente en la UCI de un hospital universitario de la municipalidad de São Paulo. Se verificó que las categorías TISS-28 que prevalecieron fueron Actividades Básicas y Soportes Ventilatorio, Cardiovascular y Renal con frecuencias entre 73,0% y 100%. La frecuencia de los ítems componentes de la categoría Actividades Básicas fue prevaliente, ou sea, mayor que el 90,0%. La medida cuantitativa del débito urinario fue puntuado en 98,2% en la categoría Soporte Renal. Los resultados obtenidos pueden imprimir calidad a la asistencia prestada a los clientes, en la medida en que contribuyen a la previsión de recursos humanos y materiales en la UCI.The present study aimed to identify the therapeutic interventions categories

  2. Neutrophil-lymphocyte ratio, pain perception, and disease activity score may serve as important predictive markers for sustained remission in rheumatoid arthritis

    S. Chandrashekara

    2016-02-01

    Full Text Available The implementation of new treatment strategies based on current recommendations has enabled a greater number of patients with rheumatoid arthritis (RA to achieve remission. However, there are no definite predictors of sustained remission. Moreover, the absence of clear consensus on the time of withdrawal or reduction of treatment further adds to the treatment burden. This pilot study was intended to evaluate the prognostic potential of various RA-related parameters. All the enrolled subjects (n=124 were clinically evaluated on the basis of various parameters including age, gender, duration of illness before the initiation of disease-modifying anti-rheumatic drugs, tender and swollen joints (28 joints, erythrocyte sedimentation rate (ESR, C-reactive protein (CRP, hemoglobin percentage, lymphocyte count, total white-blood cell counts, and neutrophil to lymphocyte ratio (NLR. Student’s t-test and discriminant function analysis were performed. The specificity of all parameters and their best possible cut-off to predict relapse were calculated using the receiver operating characteristic (ROC analysis. A significant difference in terms of pain perception, NLR, tendency to have a significant tender joint count and absolute lymphocyte counts was identified between the patients in sustained remission and those in relapse. The ROC analysis indicated that NLR was consistent in predicting remission. CRP, ESR, and/or disease activity score may not be very effective in differentiating patients with sustainable remission/low disease activity. NLR along with patient’s perception of pain may assist in predicting sustained remission.

  3. Assessment of Disease Activity in Small Bowel Crohn’s Disease: Comparison between Endoscopy and Magnetic Resonance Enterography Using MRIA and Modified MRIA Score

    Arnaldo Scardapane

    2015-01-01

    Full Text Available Objectives. To retrospectively compare the results of the MRIA (magnetic resonance index of activity with a modified MRIA (mMRIA, which was calculated excluding from MRIA formula the data of relative contrast enhancement (RCE. Materials and Methods. MR-E and corresponding endoscopic records of 100 patients were reviewed. MRIA, mMRIA, and SES endoscopic index were calculated for all the patients. Namely, MRIA was calculated as follows: (1.5 × wall thickening + 0.02 × RCE + 5 × intramural edema + 10 × ulcers, while mMRIA was calculated with the modified formula (1.5 × wall thickening + 5 × intramural edema + 10 × ulcers. Results. Mean MRIA and mMRIA values were 19.3 and 17.68, respectively p<0.0001. A significant correlation p<0.0001 was observed between MRIA and mMRIA scores and between both MR indexes and SES p<0.0001. Conclusions. mMRIA was comparable to MRIA in the evaluation of disease activity in Crohn’s disease.

  4. Assessment of Disease Activity in Small Bowel Crohn's Disease: Comparison between Endoscopy and Magnetic Resonance Enterography Using MRIA and Modified MRIA Score

    Scardapane, Arnaldo; Ambrosi, Annalisa; Salinaro, Emanuela; Mancini, Maria Elisabetta; Principi, Mariabeatrice; Di Leo, Alfredo; Lorusso, Filomenamila; Stabile Ianora, Amato Antonio; Angelelli, Giuseppe

    2015-01-01

    Objectives. To retrospectively compare the results of the MRIA (magnetic resonance index of activity) with a modified MRIA (mMRIA), which was calculated excluding from MRIA formula the data of relative contrast enhancement (RCE). Materials and Methods. MR-E and corresponding endoscopic records of 100 patients were reviewed. MRIA, mMRIA, and SES endoscopic index were calculated for all the patients. Namely, MRIA was calculated as follows: (1.5 × wall thickening + 0.02 × RCE + 5 × intramural edema + 10 × ulcers), while mMRIA was calculated with the modified formula (1.5 × wall thickening + 5 × intramural edema + 10 × ulcers). Results. Mean MRIA and mMRIA values were 19.3 and 17.68, respectively (p < 0.0001). A significant correlation (p < 0.0001) was observed between MRIA and mMRIA scores and between both MR indexes and SES (p < 0.0001). Conclusions. mMRIA was comparable to MRIA in the evaluation of disease activity in Crohn's disease. PMID:26759554

  5. Duke Activity Status Index em Doenças Cardiovasculares: Validação de Tradução em Português

    Mariana A. Coutinho-Myrrha

    2014-04-01

    Full Text Available Fundamentos: O Duke Activity Status Index (DASI avalia a capacidade funcional de pacientes com doença cardiovascular (DCV, mas não há versão validada em português para doenças cardiovasculares. Objetivos: Traduzir e adaptar culturalmente o DASI para o idioma português do Brasil, e verificar suas propriedades psicométricas na avaliação da capacidade funcional de pacientes com doenças cardiovasculares. Métodos: O DASI foi traduzido para o português, verificado pela retrotradução para o inglês e avaliado por um comitê de especialistas. A versão pré-teste foi avaliada pela primeira vez em 30 indivíduos. As propriedades psicométricas e a correlação com o teste de esforço foram verificadas em um segundo grupo de 67 indivíduos. Uma análise fatorial exploratória foi realizada em todos os 97 pacientes para verificar a validade de construto do DASI. Resultados: O coeficiente de correlação intraclasse para a confiabilidade teste-reteste foi de 0,87 e para a confiabilidade entre avaliadores foi de 0,84. O alfa de Cronbach para consistência interna foi de 0,93. A validade concorrente foi verificada por correlações positivas significativas de pontuações do DASI com o VO2 max (r = 0,51, p < 0,001. A análise fatorial mostrou dois fatores que explicaram 54% da variância total, com o fator 1 responsável por 40 % da variância. A aplicação do DASI requer entre um e três minutos e meio por paciente. Conclusão: A versão brasileira do DASI parece ser um instrumento válido, confiável, rápido e fácil de administrar para avaliar a capacidade funcional em pacientes com doenças cardiovasculares.

  6. Atividade sérica das enzimas AST, CK e GGT em cavalos Crioulos AST, CK and GGT enzymes serum activities in Crioulo horses

    Carina Franciscato

    2006-10-01

    Full Text Available O objetivo deste trabalho foi verificar a influência da idade, sexo, manejo e estado gestacional sobre a atividade sérica das enzimas: aspartato aminotransferase (AST, creatina quinase (CK e gama-glutamiltransferase (GGT em cavalos da raça Crioula. Foram utilizados 142 eqüinos, divididos em seis grupos: potros até um ano de idade; cavalos adultos em regime de atividade livre; cavalos adultos em treinamento; machos adultos; fêmeas não gestantes; fêmeas gestantes. O valor da CK foi mais elevado em animais adultos do que em potros, o mesmo tendo ocorrido em animais em atividade livre, comparados a animais em treinamento. Fêmeas não gestantes apresentaram valores das enzimas CK e GGT maiores que os machos; o valor da CK em fêmeas gestantes foi mais elevado do que em fêmeas não gestantes. A idade, o sexo, o manejo e o estado gestacional influenciam a atividade sérica da CK, e o sexo influencia a atividade sérica da GGT.The objective of this work was to evaluate the influence of age, sex, management and pregnancy status on aspartate aminotransferase (AST, creatine kinase (CK and gamma-glutamyltransferase (GGT enzymes serum activities of Crioulo horses. One hundred and forty-two horses, divided into six group were analyzed: yearlings; free activity of adult horses; training adult horses; male adult horses; nonpregnant and pregnant females. The CK enzyme activity value was higher in adult horses than in yearlings, and the same result was found when comparing free activity and training horses. Nonpregnant females had higher values for CK and GGT comparing to male horses, and CK values were higher in pregnant comparing to nonpregnant females. Age, sex, management and pregnancy status influence on CK serum activity, and sex influences on GGT serum activity.

  7. Translation, Validation and Cross-Cultural Adaptation of a Simplified-Chinese Version of the Tegner Activity Score in Chinese Patients with Anterior Cruciate Ligament Injury

    Zhang, Dongxia; Jiang, Yanfang; Yang, Jie; Feng, Tao; Gong, Xi; Wang, Jianquan; Ao, Yingfang

    2016-01-01

    Aims To translate the English version of Tegner Activity Score into a Simplified-Chinese version (Tegner-C) and evaluate its psychometric properties. Methods Tegner-C was cross-culturally adapted according to established guidelines. The validity and reliability of Tegner-C were assessed in 78 participants, with 19–20 participants in each of the four groups: before anterior cruciate ligament reconstruction (pre-ACLR) group, 2–3 months after ACLR group, 3–12 months after ACLR group, and healthy control group. Each participant was asked to complete the Tegner-C and Chinese version of International Knee Documentation Committee Subjective Knee Form (IKDC-SKF-C) twice, with an interval of 5±2 days. Intra-class correlation coefficient (ICC2, 1) was used to assess the reliability and Spearman’s rank correlation was used for construct validity. Results The ICC2,1 was higher than 0.90 for all groups except in the pre-ACLR group, for which the ICC2,1 was 0.71 (0.41, 0.87) (All with pACL injury. PMID:27186880

  8. Carga de trabajo en tres grupos de pacientes de UCI Española según el Nursing Activities Score

    Francisco Javier Carmona-Monge

    2013-04-01

    Full Text Available Se objetivó valorizar la carga de trabajo al ingreso y al alta en tres grupos de pacientes (síndrome coronario agudo, insuficiencia respiratoria aguda y sepsis en terapia intensiva. Estudio descriptivo, prospectivo, de 27 meses, incluyéndose 563 pacientes, valorando carga de trabajo según Nursing Activities Score. Existieron diferencias significativas en la carga de trabajo al ingreso y en el alta entre los grupos de pacientes, siendo superior en ambos momentos la de pacientes con insuficiencia respiratoria aguda y sepsis frente a pacientes coronarios. Durante los siete primeros días de estancia se mantuvo esta diferencia, desapareciendo a partir del octavo día, equilibrándose la carga de trabajo para los tres grupos. Para conseguir una adecuada dotación de personal es fundamental contar con instrumentos para medir las necesidades de cuidados y conocer la carga de trabajo de los distintos grupos de enfermos que ingresan con mayor frecuencia en las unidades de terapia intensiva.

  9. Reporting Valid and Reliable Overall Scores and Domain Scores

    Yao, Lihua

    2010-01-01

    In educational assessment, overall scores obtained by simply averaging a number of domain scores are sometimes reported. However, simply averaging the domain scores ignores the fact that different domains have different score points, that scores from those domains are related, and that at different score points the relationship between overall…

  10. Sampling quality assurance guidance in support of EM environmental sampling and analysis activities

    This document introduces quality assurance guidance pertaining to the design and implementation of sampling procedures and processes for collecting environmental data for DOE's Office of EM (Environmental Restoration and Waste Management)

  11. Sampling quality assurance guidance in support of EM environmental sampling and analysis activities

    1994-05-01

    This document introduces quality assurance guidance pertaining to the design and implementation of sampling procedures and processes for collecting environmental data for DOE`s Office of EM (Environmental Restoration and Waste Management).

  12. DNA Topoisomerases Maintain Promoters in a State Competent for Transcriptional Activation in <em>Saccharomyces cerevisiaeem>

    Pedersen, Jakob Madsen; Fredsøe, Jacob Christian; Rødgaard, Morten Terpager; Andreasen, Lotte; Mundbjerg, Kamilla; Kruhøffer, Mogens; Brinch, Marie; Schierup, Mikkel Heide; Bjergbæk, Lotte; Andersen, Anni Hangaard

    -depth analysis of the inducible PHO5 gene reveals that topoisomerases are essential for binding of the Pho4p transcription factor to the PHO5 promoter, which is required for promoter nucleosome removal during activation. In contrast, topoisomerases are dispensable for constitutive transcription initiation and...... elongation of PHO5, as well as the nuclear entrance of Pho4p. Finally, we provide evidence that topoisomerases are required to maintain the PHO5 promoter in a superhelical state, which is competent for proper activation. In conclusion, our results reveal a hitherto unknown function of topoisomerases during...

  13. Variation in Minerals, Phenolics and Antioxidant Activity of Peel and Pulp of Different Varieties of Peach (<em>Prunus persicaem> L. Fruit from Pakistan

    Muhammad Ashraf

    2012-05-01

    Full Text Available Peach (<em>Prunus persicaem> L., being a potential source of bioactive compounds, has been demonstrated to have medicinal benefits. In this study variation of minerals and antioxidant characteristics (total phenolic contents, total flavonoid contents, reducing power, inhibition of peroxidation using linoleic acid system and DPPH free radical scavenging activity between peel and pulp parts of different peach varieties, namely Golden, Shireen, and Shahpasand were investigated. The peel and pulp extracts, derived from the varieties analyzed, exhibited an appreciable amount of total phenolics (TP and total flavonoids (TF, ranging from 1,209.3–1,354.5, 711.7–881.3 mg GAE/100 g and 599.7–785.5, 301.3–499.7 mg CE/100 g on a dry weight basis, respectively. Reducing power of peel and pulp extracts (12.5 mg/mL concentration ranged from 2.57–2.77 and 1.54–1.99.The inhibition of linoleic acid peroxidation and DPPH scavenging activity of the extracts varied from 70.8–80.9% and 66.8–76.5% in peels, and 51.9–60.1% and 43.4–49.1% in pulps. The mineral analysis revealed that the content of K was highest in both parts of the peach fruit followed by Mg, Ca, Fe, Mn and Zn. The results of our present study indicate that peach peel had significantly higher levels of minerals, antioxidant capacity and phenolics than those of the pulp, suggesting the intake of unpeeled peach as a potential source of high-value components. The peach peel can be a useful as a viable source of natural antioxidants for functional foods and nutraceutical applications.

  14. Comparação entre dois escores de prognóstico (PRISM e PIM em unidade de terapia intensiva pediátrica Comparison of two prognostic scores (PRISM and PIM at a pediatric intensive care unit

    Vanessa Feller Martha

    2005-06-01

    Full Text Available OBJETIVO: Comparar o desempenho do PRISM (Pediatric Risk of Mortality e o PIM (Pediatric Index of Mortality em uma unidade de terapia intensiva pediátrica geral investigando a relação existente entre a mortalidade e a sobrevivência observadas com a mortalidade e sobrevivência estimadas pelos dois escores. MÉTODOS: Estudo de coorte contemporâneo realizado entre 1° de junho de 1999 a 31 de maio de 2000 na unidade de terapia intensiva pediátrica do Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul. Os critérios de inclusão no estudo e o cálculo do PRISM e do PIM foram feitos conforme preconizado e utilizando as fórmulas de seus artigos originais. Para estatística, utilizou-se o teste z de Flora, teste de ajuste de Hosmer-Lemeshow, área sob a curva típica de um recebedor operador de características (curva ROC e teste de correlação de Spearman. O estudo foi aprovado pelo Comitê da instituição. RESULTADOS: Internaram na unidade de terapia intensiva pediátrica 498 pacientes, sendo 77 excluídos. Dos 421 pacientes estudados, 33 (7,83% foram a óbito. A mortalidade estimada pelo PRISM foi de 30,84 (7,22%, com standardized mortality rate 1,07 (0,74-1,50, z = -0,45. Pelo PIM, foi de 26,13 (6,21%, com standardized mortality rate 1,26 (0,87-1,77, z = -1,14. O teste de ajuste de Hosmer-Lemeshow obteve um qui-quadrado 9,23 (p = 0,100 para o PRISM e 27,986 (p OBJECTIVE: To compare the performance of the PRISM (Pediatric Risk of Mortality and the PIM (Pediatric Index of Mortality scores at a general pediatric intensive care unit, investigating the relation between observed mortality and survival and predicted mortality and survival. METHODS: A contemporary cohort study undertaken between 1 June 1999 and 31 May 2000 at the Pontifícia Universidade Católica do Rio Grande do Sul, Hospital São Lucas pediatric intensive care unit. The inclusion criteria and the PRISM and PIM calculations were performed as set out

  15. APHASIE HANDICAP SCORE

    Detante, Olivier

    2004-01-01

    Stroke is the leading cause of disability for adults. Handicap assessment is required to improve follow-up and for clinical trials. The modified Rankin scale is a "best-seller" which has contributed to prove efficacy of thrombolysis. This global score of disability is simple and patient-oriented. It seems interesting to developp such global scoring for aphasia. Our aim was to validate a simple and reproductible tool for handicap due to every type of aphasia. Aphasia Handicap Score (AHS) was d...

  16. The Bandim tuberculosis score

    Rudolf, Frauke; Joaquim, Luis Carlos; Vieira, Cesaltina;

    2013-01-01

    Background: This study was carried out in Guinea-Bissau's capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2...... physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method: From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and...

  17. Volleyball Scoring Systems.

    Calhoun, William; Dargahi-Noubary, G. R.; Shi, Yixun

    2002-01-01

    The widespread interest in sports in our culture provides an excellent opportunity to catch students' attention in mathematics and statistics classes. One mathematically interesting aspect of volleyball, which can be used to motivate students, is the scoring system. (MM)

  18. Relationship between the climbing up and climbing down stairs domain scores on the FES-DMD, the score on the Vignos Scale, age and timed performance of functional activities in boys with Duchenne muscular dystrophy

    Lilian A. Y. Fernandes

    2014-12-01

    Full Text Available BACKGROUND: Knowing the potential for and limitations of information generated using different evaluation instruments favors the development of more accurate functional diagnoses and therapeutic decision-making. OBJECTIVE: To investigate the relationship between the number of compensatory movements when climbing up and going down stairs, age, functional classification and time taken to perform a tested activity (TA of going up and down stairs in boys with Duchenne muscular dystrophy (DMD. METHOD: A bank of movies featuring 30 boys with DMD performing functional activities was evaluated. Compensatory movements were assessed using the climbing up and going down stairs domain of the Functional Evaluation Scale for Duchenne Muscular Dystrophy (FES-DMD; age in years; functional classification using the Vignos Scale (VS, and TA using a timer. Statistical analyses were performed using the Spearman correlation test. RESULTS: There is a moderate relationship between the climbing up stairs domain of the FES-DMD and age (r=0.53, p=0.004 and strong relationships with VS (r=0.72, p=0.001 and TA for this task (r=0.83, p<0.001. There were weak relationships between the going down stairs domain of the FES-DMD-going down stairs with age (r=0.40, p=0.032, VS (r=0.65, p=0.002 and TA for this task (r=0.40, p=0.034. CONCLUSION: These findings indicate that the evaluation of compensatory movements used when climbing up stairs can provide more relevant information about the evolution of the disease, although the activity of going down stairs should be investigated, with the aim of enriching guidance and strengthening accident prevention. Data from the FES-DMD, age, VS and TA can be used in a complementary way to formulate functional diagnoses. Longitudinal studies and with broader age groups may supplement this information.

  19. Comparação entre provas de função pulmonar, escore de Shwachman-Kulczycki e escore de Brasfield em pacientes com fibrose cística Comparison among pulmonary function test results, the Shwachman-Kulczycki score and the Brasfield score in patients with cystic fibrosis

    Ivanice Duarte Freire; FERNANDO ANTÔNIO DE ABREU E SILVA; Manuel Ângelo de Araújo

    2008-01-01

    OBJETIVO: Estudar as relações entre função pulmonar, radiologia de tórax e estado clínico em fibrose cística. MÉTODOS: Em estudo transversal e retrospectivo, analisaram-se prontuários e radiografias de pacientes do Hospital de Clínicas de Porto Alegre. Foram estudados as espirometrias e os escores de Shwachman-Kulczycki (S-K) e de Brasfield. RESULTADOS: A amostra final constituiu-se de 40 pacientes com média de idade de 9,72 ± 3,27. Foram obtidas as seguintes médias dos escores de S-K: total,...

  20. The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite <em>Plasmodium falciparum in vitroem> and rodent parasites <em>Plasmodium bergheiem> and <em>Plasmodium> <em>yoelii in vivoem>

    Chen, M; Brøgger Christensen, S; Zhai, L;

    1997-01-01

    growth of both a chloroquine-susceptible (3D7) and a chloroquine-resistant (Dd2) strain of Plasmodium falciparum in a [3H]hypoxanthine uptake assay. The in vivo activity of 2,4mbc was tested in mice infected with Plasmodium berghei or Plasmodium yoelii and in rats infected with P. berghei. 2,4mbc...... activity and might be developed into a new antimalarial drug....

  1. Fatty acid composition in serum correlates with that in the liver and non-alcoholic fatty liver disease activity scores in mice fed a high-fat diet.

    Wang, Xing-He; Li, Chun-Yan; Muhammad, Ishfaq; Zhang, Xiu-Ying

    2016-06-01

    In this study, we investigated the correlation between the serum fatty acid composition and hepatic steatosis, inflammation, hepatocellular ballooning scores, and liver fatty acids composition in mice fed a high-fat diet. Livers were collected for non-alcoholic fatty liver disease score analysis. Fatty acid compositions were analysed by gas chromatography. Correlations were determined by Pearson correlation coefficient. Exposed to a high-fat diet, mice developed fatty liver disease with varying severity without fibrosis. The serum fatty acid variation became more severe with prolonged exposure to a high-fat diet. This variation also correlated significantly with the variation in livers, with the types of fatty acids corresponding to liver steatosis, inflammation, and hepatocellular ballooning scores. Results of this study lead to the following hypothesis: the extent of serum fatty acid variation may be a preliminary biomarker of fatty liver disease caused by high-fat intake. PMID:27179602

  2. Active accumulation of internal DIC pools reduces transport limitation in large colonies of <em>Nostoc pruniformeem>

    Raun, Ane-Marie Løvendahl; Borum, Jens; Jensen, Kaj Sand

    2009-01-01

    Nostoc pruniforme is a freshwater cyanobacterium forming large spherical colonies of up to several centimeters in diameter. The size and shape result in low surface area to volume (SA/V) ratios that potentially put severe constraints on resource acquisition. In the present study we have...... polysaccharides contains declining densities of trichomes with increasing colony size. N. pruniforme is a very efficient bicarbonate (HCO3-) user and, in addition, actively accumulates large pools of DIC that can support net photosynthesis for >22 h without a supply of external DIC. Both the efficient HCO3......- utilization and the large internal DIC pools greatly reduce N. pruniforme dependence on the immediate availability and species of external DIC. The location of the trichomes in the shell, the HCO3- utilization and the internal DIC pools mean that colony size only has a minor effect on photosynthetic rates as...

  3. Rationale and study protocol for the supporting children’s outcomes using rewards, exercise and skills (SCORES) group randomized controlled trial: A physical activity and fundamental movement skills intervention for primary schools in low-income communities

    Lubans David R; Morgan Philip J; Weaver Kristen; Callister Robin; Dewar Deborah L; Costigan Sarah A; Finn Tara L; Smith Jordan; Upton Lee; Plotnikoff Ronald C

    2012-01-01

    Abstract Background Many Australian children are insufficiently active to accrue health benefits and physical activity (PA) levels are consistently lower among youth of low socio-economic position. PA levels decline dramatically during adolescence and evidence suggests that competency in a range of fundamental movement skills (FMS) may serve as a protective factor against this trend. Methods/design The Supporting Children’s Outcomes Using Rewards Exercise and Skills (SCORES) intervention is a...

  4. Atividade dos herbicidas flumioxazin e metribuzin em diferentes solos Activity of flumioxazin and metribuzin herbicides in different soils

    Maurílio F. de Oliveira; Antônio A. da Silva; Francisco A. Ferreira; Jorge M Gomes

    1998-01-01

    A atividade dos herbicidas flumioxazin e metribuzin foi avaliada, em casa-de-vegetação, em quatro tipos de solos usando areia lavada como controle. Os solos, coletados em diferentes regiões agrícolas, foram classificados como: PVc coletado em Viçosa-MG, LRd coletado em Dourados-MS, LVh em Realeza-MG e LVm em Três Marias-MG. Em vasos com capaciade de 430 cm3 foram avaliadas, para cada tipo de solo, por meio de bioensaio com pepino, dez doses de cada herbicida, com cinco repetições. O nível de ...

  5. Prática de atividade física em adolescentes brasileiros Physical activity practice among brazilian adolescents

    Pedro Curi Hallal

    2010-10-01

    Full Text Available O objetivo deste estudo é descrever a prática de atividade física em adolescentes, utilizando dados da Pesquisa Nacional de Saúde do Escolar (PeNSE, coletados em todas as capitais do Brasil e no Distrito Federal em 2009. A amostra incluiu escolares do 9º ano do ensino fundamental (n=60.973. Foram investigadas a prática de atividade física nos últimos sete dias, incluindo modo de deslocamento para a escola, prática de atividade física dentro e fora da escola e participação nas aulas de educação física. Consideraram-se ativos os jovens que acumularam > 300 min/sem de atividade física. A proporção de ativos foi de 43,1%, sendo maior nos meninos (56,2% em comparação às meninas (31,3%. Metade dos adolescentes (49,2% relatou ter tido duas ou mais aulas de educação física na semana anterior à entrevista; 79,2% relataram assistir a duas horas diárias de televisão ou mais. Os dados do PeNSE indicam baixa prevalência de jovens ativos e com duas ou mais aulas de educação física por semana, além de elevada prevalência de comportamento sedentário. Tais dados podem ser utilizados como linha de base para o monitoramento de atividade física em escolares brasileiros, mas desde já sugerem a necessidade de intervenções para a promoção de atividade física em adolescentes brasileiros.The aim of this study is to describe physical activity practice among Brazilian adolescents by using data from the National Adolescent School-based Health Survey (PeNSE collected in all state capitals and the Federal District in 2009. The sample included students of the ninth year (n=60,973. It was investigated the physical activity practice seven days prior to the interview, including transportation mode, physical activity practice inside and outside the school and participation in Physical Education classes. Adolescents were classified as active if performing > 300 min/wk of physical activity. The proportion of active adolescents was 43

  6. Increasing Active Student Responding in a University Applied Behavior Analysis Course: The Effect of Daily Assessment and Response Cards on End of Week Quiz Scores

    Malanga, Paul R.; Sweeney, William J.

    2008-01-01

    The study compared the effects of daily assessment and response cards on average weekly quiz scores in an introduction to applied behavior analysis course. An alternating treatments design (Kazdin 1982, "Single-case research designs." New York: Oxford University Press; Cooper et al. 2007, "Applied behavior analysis." Upper Saddle River:…

  7. Aplicabilidade da escala London Chest Activity of Daily Living em pacientes em lista de espera para transplante de pulmão Applicability of the London Chest Activity of Daily Living scale in patients on the waiting list for lung transplantation

    Jocimar Prates Muller; Patrícia Ayres Guterres Gonçalves; Fabrício Farias da Fontoura; Rita Mattiello; Juliessa Florian

    2013-01-01

    OBJETIVO: Avaliar a aplicabilidade da escala London Chest Activity of Daily Living (LCADL), em pacientes em lista de transplante pulmonar. MÉTODOS: Estudo transversal com 26 pacientes em lista de espera para transplante de pulmão, de ambos os sexos, entre maio e setembro de 2010 tratados no Programa de Reabilitação Pulmonar, Complexo Hospitalar Santa Casa de Misericórdia de Porto Alegre, em Porto Alegre, RS. Todos os pacientes foram submetidos ao teste de caminhada de seis minutos (TC6) e a t...

  8. Atividade da redutase de nitrato em mudas de pupunheira (Bactris gasipaes Nitrate reductase activity in peach palm (Bactris gasipaes seedlings

    Maria Aparecida José de Oliveira

    2005-06-01

    Full Text Available A enzima redutase de nitrato (EC 1.6.6.1 é a principal enzima responsável pela assimilação de nitrogênio pelas plantas e tem a atividade fortemente afetada pela disponibilidade de água no solo, por isso é usada como variável na avaliação das plantas em diferentes condições ambientais. Assim, este estudo teve como objetivo a padronização de metodologia para avaliação in vivo da atividade da redutase de nitrato em folhas e raízes de pupunheira com nove meses e um ano. As mudas foram cultivadas em casa de vegetação, e os ensaios realizados de acordo com método clássico de análise in vivo. O delineamento experimental foi inteiramente casualizado, com seis repetições. A atividade máxima da enzima em folhas foi obtida com tempo de incubação ao redor de 60 minutos, pH do meio de reação em torno de 7, temperatura de 35 a 37°C e concentração de nitrato entre 28 a 30mmolL-1. A atividade desta enzima foi maior em plantas com nove meses de idade. As folhas mostraram maior atividade da enzima quando comparadas com as raízes. A atividade da enzima redutase de nitrato variou ao longo do dia, com máxima obtida às 10:00 horas, mostrando a influência do período luminoso e do estado hídrico da planta.The nitrate reductase enzyme (EC 1.6.6.1 is the main responsible enzyme for the assimilation of nitrogen by plants and its activity is strongly affected by the soil water availability. This feature allows the use of this enzyme to evaluate plants in different environmental conditions. The objective of this study was to standardize the methodology to evaluate in vivo the nitrate reductase activity in leaves and roots of nine months and one year old peach palms (Bactris gasipaes. The plants were cultivated in a nursery and the essays were conducted according to the classical method of in vivo analyses. The experimental design was entirely randomized with six repetitions. The results showed that maximum nitrate reductase activity for

  9. APHASIE HANDICAP SCORE

    Detante, Olivier

    2004-01-01

    L'accident vasculaire cérébral (AVC) est la principale cause de handicap de l'adule dont la quantification est indispensable à l'évaluation de la qualité des soins. Le score de Rankin est un " best-seller " qui a contribué à démontrer l'efficacité de la thrombolyse. Ce score global du handicap est simple et le plus " patient-orienté " des scores actuels. Il nous a semblé intéressant d'adapter cette approche globale du handicap post-AVC au problème spécifique des aphasies. L'objectif était de ...

  10. Association between salivary α-amylase activity and pain relief scale scores in cancer patients with bone metastases treated with radiotherapy

    LIU Hong; DONG Wen-yan; WANG Jian-bo; WANG Tao; HU Peng; WEI Shu-fang; YE Lin

    2013-01-01

    Background Subjective assessment tools such as visual analog scales (VAS) or pain scores are commonly used to evaluate the intensity of chronic cancer-induced pain.However,their value is limited in some cases.We measured changes in VAS pain scores and salivary a-amylase (sAA) concentrations in cancer patients receiving radiotherapy for bone metastases to ascertain the correlation between these measures.Methods We enrolled 30 patients with bone metastases attending a single institution from June 2010 to March 2011.All patients with cancer-induced bone pain received radiation therapy (RT) at the same dose (30 Gy) and fractionation (3 Gy/ fraction,5 days/week) for palliative pain relief.We assessed heart rate (HR),systolic and diastolic blood pressures (DBP/SBP) and VAS pain scores before (d0) and after five (d5) and ten fractions (d10) of irradiation,sAA and salivary cortisol (SC)concentrations were measured using a portable analyzer and automated chemiluminescence analyzer,respectively.Results Radiotherapy markedly decreased VAS scores from (82.93±9.29) to (31.43±t16.73) mm (P <0.001) and sAA concentrations from (109.40±26.38) to (36.03±19.40) U/ml (P <0.001).Moreover,there was a significant correlation between these two indices (P <0.01,r=0.541).HR decreased by 6.5% after radiotherapy,but did not correlate with VAS scores (P >0.05).SC concentrations and BP did not change significantly during the study (P >0.05).Conclusions The significant correlation between sAA concentrations and VAS pain scores identified in these preliminary results suggests that this biomarker may be a valuable,noninvasive and sensitive index for the objective assessment of pain intensity in patients with cancer-induced bone pain.

  11. Instant MuseScore

    Shinn, Maxwell

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Instant MuseScore is written in an easy-to follow format, packed with illustrations that will help you get started with this music composition software.This book is for musicians who would like to learn how to notate music digitally with MuseScore. Readers should already have some knowledge about musical terminology; however, no prior experience with music notation software is necessary.

  12. Developing Scoring Algorithms

    We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables, dairy, added sugars, whole grains, fiber, and calcium using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES.

  13. POSSUM escore como preditor de mortalidade em pacientes cirúrgicos Utilizacion del puntaje POSSUM como indicador de la mortalidad en pacientes quirúrgicos POSSUM scoring system for predicting mortality in surgical patients

    Adriana Cristina Galbiatti Parminondi Elias; Tiemi Matsuo; Cíntia Magalhães Carvalho Grion; Lucienne Tibery Queiroz Cardoso; Paulo Henrique Verri

    2009-01-01

    O estudo avaliou a utilização do escore POSSUM (Physiological and Operative Severity Score for Enumeration of Mortality and Morbidity) para predizer a mortalidade na prática cirúrgica.Foram analisados 416 pacientes cirúrgicos com internação na UTI para cuidados de pós-operatório. Foram realizadas comparações entre as taxas de mortalidade predita e observada de acordo com 4 grupos de risco: 0-4%, 5-14%, 15-49%, 50% ou mais, e calculada a área sob a curva ROC do escore POSSUM e APACHE II para a...

  14. Condição corporal, variação de peso e desempenho reprodutivo de vacas de cria em pastagem nativa no Pantanal Body condition score, weight variation and reproductive performance of beef cows in rangelands from the Pantanal region

    Sandra Aparecida Santos

    2009-02-01

    Full Text Available Objetivou-se avaliar a influência do escore de condição corporal (ECC sobre a eficiência reprodutiva de vacas de cria nos períodos pré e pós-parto e a probabilidade de parição, usando o escore de condição corporal e a variação ponderal no período crítico do ciclo reprodutivo. Utilizaram-se 248 vacas multíparas mantidas em pastagens nativas distribuídas em quatro estratégias de suplementação: mistura mineral (controle; suplemento farelado; suplemento líquido; suplemento líquido para vacas e bezerros. As avaliações de peso e ECC, na escala de 1 a 9, foram realizadas no período crítico: em agosto (período pré-parto, 60-90 dias antes da parição e em janeiro (período pós-parto e reprodutivo durante quatro anos consecutivos. Para a análise dos anos consecutivos de reprodução, criou-se um escore de reprodução, ou seja, somou-se o número de parições de cada vaca durante os quatro anos pecuários avaliados. O escore de condição corporal nos períodos pré e pós-parto e a idade da vaca influenciaram o escore de reprodução. Portanto, para avaliação da probabilidade de parição, foram utilizadas todas as vacas, classificadas em paridas e vazias. Utilizando equações de estimação generalizadas (EEG, foi modelada a probabilidade de as matrizes serem classificadas como paridas considerando variáveis exploratórias ao longo do tempo. Para se obter probabilidade de parição superior a 80%, as vacas devem possuir escore de aproximadamente 5,5 no período pré-parto. Aproximadamente 60% das vacas paridas mantiveram ou ganharam peso no período crítico do ano, o que levou a maior probabilidade de reconcepção, similar ao observado para as vacas vazias, porém com probabilidade menor de parição. O período pré-parto é o melhor para estimar a probabilidade de parição das vacas por meio da avaliação do escore corporal. A seleção de vacas adaptadas às condições bioclimáticas do Pantanal aumenta a

  15. Risk factors for sternal wound infections and application of the STS score in coronary artery bypass graft surgery Fatores de risco para infecção de ferida esternal e aplicação do escore da STS em pacientes submetidos à cirurgia de revascularização miocárdica

    Pedro Silvio Farsky

    2011-12-01

    Full Text Available BACKGROUND: Sternal wound infection (SWI after coronary artery bypass graft (CABG surgery is a major complication. Identifying patients at risk of SWI is essential for the application of preventive measures. OBJECTIVE: To identify the pre- and intra-operative risk factors, apply the STS risk score and determine the correlation between the risk score and microorganisms isolated from surgical wounds in a Brazilian hospital. METHODS: This is a retrospective analysis of a database of all CABG surgeries performed in a single institution from 2006 to 2008. Chi-square analysis was used for categorical variables and Student's t-test was used for quantitative variables. Multivariate logistic regression model was used to identify independent risk factors for SWI. P 40 kg/m² (OR 6.27, 95%CI 2.53-15.48; P40 kg/m², number of affected coronary arteries and use of bilateral internal thoracic artery were associated with a higher risk of infection. The STS risk score can be successfully used and there was no correlation between microorganisms, the score and risk factors at our institution.FUNDAMENTO: A infecção de ferida operatória esternal após cirurgia de revascularização miocárdica (CRM é uma grave complicação. Identificar pacientes com risco elevado é fundamental para introdução de medidas de preventivas. OBJETIVO: Identificar os fatores de risco pré e intra-operatórios, avaliar o escore de risco da STS e correlação entre o escore e os microorganismos isolados em ferida operatória em hospital brasileiro. MÉTODOS: Análise retrospectiva de um banco de dados prospectivamente coletado de todas as CRM realizadas em centro único, no período de 2006 a 2008. Teste do qui-quadrado foi utilizado para variáveis categóricas e teste t-Student, para variáveis quantitativas. Modelo multivariado por regressão logística foi utilizado para identificação de fatores de risco independente para infecção de ferida esternal. P40 kg/m² (OR 5,38; IC

  16. Atividade física e qualidade de vida em mulheres com 60 anos ou mais: fatores associados Physical activity and quality of life in women aged 60 or older: associated factors

    Euller Duarte de Carvalho

    2010-09-01

    a boa autopercepção da saúde aumentou o escore de qualidade de vida em 7,3 pontos; o uso de maior número de medicamentos diminuiu em 4,4 pontos; e a prática de exercícios físicos moderados ou vigorosos aumentou em 4,8 pontos o referido escore. CONCLUSÕES: as mulheres despendem muito tempo na posição sentada. Evidenciou-se a importância da prática de exercícios físicos de intensidade moderada/vigorosa contribuindo para a obtenção de uma boa qualidade de vida.PURPOSE: to evaluate the level of physical activity, quality of life and associated factors in women aged 60 or older. METHODS: a cross-sectional study was conducted on 271 women who go to a Leisure Center and women attended at a menopause ambulatory in Campinas (SP. The women were invited to take part in the research, carried out through interviews. The instruments used were the version 8 of the International Physical Activity Questionnaire (IPAQ modified for the elderly population in order to evaluate their physical activity, and the World Health Organization Questionnaire of Quality of Life specific for this group (WHOQOL-OLD to evaluate their quality of life. IPAQ results were assessed using tertiles. The association between the WHOQOL-OLD and the IPAQ results and subject characteristics was assessed by the Student's t test, Mann-Whitney test and multiple analyses. RESULTS: the average age of women was 67.4±5.3 years. Among these women, 33% were classified as being less active. Analysis of each physical activity domain showed that 60.8% of the time was spent in sitting activities (1,701.6±986.1 minutes/week. Multiple analyses indicated that attending a leisure center in Campinas (SP and being 70 years old or older increased the chances of engaging in moderate-intensity or vigorous-intensity physical activity by 11.4 and 2.8 times, respectively. The average quality of life score was 66.9±11.7. The highest value was observed in the domain related to sensory abilities (72.0±18.8 and the

  17. Built environment score related to leisure-time physical activity: application in a region of low socioeconomic status. http://dx.doi.org/10.5007/1980-0037.2013v15n2p243

    Emanuel Péricles Salvador; Vanessa Valente Guimarães; Leandro Martin Totaro Garcia; Alex Antonio Florindo; Homero Fonseca; Rodrigo Siqueira Reis; José Cazuza Farias Júnior

    2013-01-01

    There is little evidence on the relationship between leisure-time physical activity (LTPA) and built environment in Brazil, especially in areas of low socioeconomic status. The objective of this study was to describe indicators of built environment score related to LTPA for adults living in a region of low socioeconomic status. We conducted a cross-sectional study of 767 adults living in Ermelino Matarazzo district in São Paulo, 2007. The dependent variable was the practice of LTPA (in minute...

  18. Validade e equivalência da versão em português do Veterans Specific Activity Questionnaire

    Geraldo de Albuquerque Maranhão-Neto

    2011-08-01

    Full Text Available FUNDAMENTO: O Veterans Specific Activity Questionnaire (VSAQ tem sido utilizado para a individualização de testes ergométricos (TE e para avaliar indiretamente a aptidão cardiorrespiratória (ACR em estudos epidemiológicos. Apesar disso, ainda não há versão em português validada. OBJETIVO: Verificar a validade de critério da versão em português do VSAQ e examinar a equivalência de mensuração dessa versão em 95 indivíduos, sendo 8 mulheres (69 ± 7 anos, com indicação para a realização de TE. MÉTODOS: Os indivíduos realizaram teste cardiopulmonar de exercício progressivo máximo em ciclo-ergômetro. A correlação do escore do VSAQ com o MET Máximo Medido e Estimado foi comparada com os resultados de outros estudos. O Nomograma VSAQ foi calculado e seus resultados comparados com os valores reais da ACR por regressão linear. Limites de concordância e as diferenças médias (vieses foram avaliados segundo a metodologia proposta por Bland e Altman. RESULTADOS: Os escores obtidos através do VSAQ correlacionaram-se de forma significativa com o MET máximo medido (r = 0,64 e estimado (r = 0,67, resultados equivalentes àqueles obtidos com versões originais. O nomograma VSAQ obteve resultados com R múltiplo de 0,78 (para MET medido e 0,80 (para MET estimado. O nomograma, entretanto, parece subestimar os valores de indivíduos com ACR acima de 6 MET. CONCLUSÃO: A versão do VSAQ confirmou-se válida e equivalente à versão original, especialmente para avaliação de indivíduos cardiopatas e de idade avançada.

  19. EM International. Volume 1

    1993-07-01

    It is the intent of EM International to describe the Office of Environmental Restoration and Waste Management`s (EM`s) various roles and responsibilities within the international community. Cooperative agreements and programs, descriptions of projects and technologies, and synopses of visits to international sites are all highlighted in this semiannual journal. Focus on EM programs in this issue is on international collaboration in vitrification projects. Technology highlights covers: in situ sealing for contaminated sites; and remote sensors for toxic pollutants. Section on profiles of countries includes: Arctic contamination by the former Soviet Union, and EM activities with Germany--cooperative arrangements.

  20. Plasma factor VII-activating protease is increased by oral contraceptives and induces factor VII activation <em>in-vivo>

    Sidelmann, Johannes Jakobsen; Skouby, Sven O.; Kluft, Cornelis;

    2011-01-01

    Oral contraceptive (OC) use influences the hemostatic system significantly and is a risk factor for development of cardiovascular disease. Factor VII-activating protease (FSAP) has potential effects on hemostasis. The 1601GA genotype of the 1601G/A polymorphism in the FSAP gene expresses a FSAP...

  1. Music Score for Sticky

    Zhao, Enguang

    2015-01-01

    The thesis is a film composition scoring for the animated documentary film Sticky directed and produced by Jilli Rose, 2013. The film is 20 minutes long and talking about an expedition to the Ball's Pyramid Island, Australia, and the discovery of the stick insect-a type of phasmid which has disappeared on the Lord Howe Island, Australia since 1920, and how to rescue it and preserve it. The music is mainly composed based on orchestra and combining some electronic synthesis instruments with e...

  2. Dried chicory root modifies the activity and expression of porcine hepatic CYP3A but not 2C – Effect of <em>in vitroem> and<em> in vivoem> exposure

    Rasmussen, Martin Krøyer; Zamaratskaia, Galia; Andersen, Bente;

    2012-01-01

    Hepatic cytochrome P450 expression and activity are dependent on many factors, including dietary ingredients. In the present study, we investigated the in vivo and in vitro effect of chicory root on hepatic CYP3A and 2C in male pigs. Chicory feeding increased the expression of CYP3A29 mRNA but not...... CYP2C33. Correspondingly, CYP3A activity was increased by chicory feeding, while CYP2C activity was not affected. Additionally, the in vitro effect of chicory extract on the CYP3A activity was investigated. It was shown that CYP3A activity in the microsomes from male pigs was inhibited, but this...... effect was eliminated by pre-incubation. In both male and female pigs the CYP3A activity was increased in the presence of chicory after pre-incubation. Furthermore, gender-related differences in mRNA expression and activity were observed. CYP3A mRNA expression was greater in female pigs; this was not...

  3. Evaluation of Pseudopteroxazole and Pseudopterosin Derivatives against <em>Mycobacterium> <em>tuberculosis> and Other Pathogens

    McCulloch, Malcolm W. B.; Brad Haltli; Marchbank, Douglas H.; Kerr, Russell G.

    2012-01-01

    Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin congeners along with simple synthetic mimics of the terpene skeleton were synthesized. In order to build structure-activity relationships, a set of 29 new and previously reported compounds was assessed for <em>in> <em>vitro...

  4. Fatores de risco associados à mortalidade infantil em duas áreas da região metropolitana de São Paulo (Brasil, 1984-1985: proposta de instrumentos preditivos Risk factors associated with infant mortality in two municipalities of the metropolitan area of S.Paulo (Brazil, 1984-1985: proposal for a predictive scoring system

    Chester L. G. Cesar

    1990-08-01

    Full Text Available Estudou-se a aplicação do conceito de "risco" na área materno-infantil, partindo da proposta da Organização Mundial de Saúde relativa ao "enfoque de risco" na organização dos serviços de saúde. O estudo concentrou-se no desenvolvimento de instrumentos de identificação de grupos de alto risco de óbito infantil, seja no período neonatal, seja no período pós-neonatal, e baseou-se em estudo de caso-controle. O grupo de casos correspondeu a óbitos registrados de menores de um ano de idade, ocorridos nos anos de 1984 e 1985, de pais residentes nos municípios de Cotia e Vargem Grande Paulista, SP (Brasil, totalizando 149 óbitos (casos. O grupo controle foi formado por uma amostra probabilística de 216 crianças nascidas em 1984, filhas de pais residentes nos municípios estudados e que sobreviveram ao primeiro ano de vida, As mães de ambos os grupos responderam a um questionário, aplicado em entrevistas domiciliarias, para a identificação de variáveis independentes associadas ao óbito infantil. As variáveis que mostraram associação estatisticamente significante foram agrupadas em quatro escalas de risco: para uso em pré-natal; para uso por ocasião do parto; para uso no período neonatal; e para uso em puericultura após o período neonatal. As variáveis participaram nas escalas ponderadas pelos valores das razões dos produtos cruzados. As escalas apresentaram diferentes pontos de corte e a cada um destes correspondeu uma dada sensibilidade, especificidade e poder preditivo.The application of the concept of "risk" to maternal and child health was studied, the starting point being the World Health Organization's proposal for a "risk approach" in health services. The study was concerned with the development of a scoring system for the identification of groups at high risk of death during the first year of life, whether in the neonatal or the post-neonatal periods, and was based on a case-control study. The case group

  5. Estimativa do potencial produtivo em trigo utilizando sensor óptico ativo para adubação nitrogenada em taxa variável Wheat yield potential estimation using active optical sensor for site-specific nitrogen fertilization

    Christian Bredemeier

    2013-01-01

    Full Text Available A adubação nitrogenada em trigo é baseada no potencial produtivo da cultura, teor de matéria orgânica do solo e cultura antecessora. A definição do potencial produtivo é complexa, pois este varia com as condições meteorológicas de cada ano específico. O objetivo deste trabalho foi avaliar a relação entre o índice de vegetação por diferença normalizada (NDVI, medido por sensor óptico ativo e o rendimento de grãos em quatro cultivares de trigo, visando a desenvolver procedimentos para a adubação nitrogenada em cobertura em taxa variável. O experimento foi realizado em campo em 2009. Foram avaliados o NDVI em diferentes estádios de desenvolvimento e o rendimento de grãos. As leituras do NDVI ao longo do ciclo ativo foram eficientes em identificar variações de produtividade do trigo. Assim, o potencial de produtividade pode ser estimado através de medições desse índice durante a ontogenia da planta. Pode-se adotar um modelo único para descrever a relação entre NDVI e potencial produtivo para as cultivares testadas neste trabalho.Nitrogen fertilization in spring wheat is based on yield potential, soil organic matter content and previous crop. Yield potential definition is difficult, since it is affected by weather conditions. The objective of this research was to evaluate the relationship between Normalized Difference Vegetation Index (NDVI measured by an active sensor and grain yield of four wheat cultivars. The experiment was carried out at field conditions in 2009. NDVI in different growth stages and grain yield were evaluated. NDVI measured was efficient to detect growth variability generated by N availability and correlated well with grain yield for all cultivars tested, indicating that yield potential can be estimated by NDVI evaluations during crop ontogeny. One single model for the relationship between NDVI and yield potential can be used considering cultivars used in this research.

  6. A comparison of manual therapy and active rehabilitation in the treatment of non specific low back pain with particular reference to a patient's Linton & Hallden psychological screening score: a pilot study

    Stephenson Richard

    2007-11-01

    Full Text Available Abstract Background Clinical guidelines for the management of back pain frequently recommend 'manual therapy' as a first line intervention, with psychosocial screening and 'active rehabilitation' for those not improving at 6 weeks post onset. The potential for psychosocial factors to predict treatment response and therefore outcome has not been adequately explored. The purpose of this pilot study was to determine the feasibility of a study to compare manual therapy and active rehabilitation outcomes for subjects with sub-acute/chronic back pain, investigate whether any difference in outcome was related to psychosocial factors, and to inform the design of a main study. Methods A convenience sample of 39 patients with non-specific low back pain referred to the physiotherapy department of an acute NHS Trust hospital was recruited over a nine month period. Patients completed the Linton and Hallden psychological screening questionnaire (LH and were allocated to a low LH (105 or below or high LH (106 or above scoring group. The low or high LH score was used to sequentially allocate patients to one of two treatment groups – Manual Therapy comprising physiotherapy based on manual means as chosen by the treating therapist or Active Rehabilitation comprising a progressive exercise and education programme – with the first low LH scoring patient being allocated to active rehabilitation and the next to manual therapy and so on. Treatment was administered for eight sessions over a four-week period and outcome measures were taken at baseline and at four weeks. Measures used were the Roland Morris Questionnaire (RMQ, two components of the Short Form McGill (total pain rating index [PRI] and pain intensity via visual analogue scale [VAS], and the LH. Results The manual therapy group demonstrated a greater treatment effect compared with active rehabilitation for RMQ (mean difference 3.6, 95% CI 1.1 – 6.2, p = 0.006 and PRI (7.1, 95% CI 2.0 – 12.2, p = 0

  7. Olympic Scoring of English Compositions

    Follman, John; Panther, Edward

    1974-01-01

    Examines empirically the efficacy of utilizing Olympic diving and gymnastic scoring systems for grading graduate students' English compositions. Results indicated that such scoring rules do not produce ratings different in reliability or in level from conventional letter grades. (ED)

  8. Customizing Scoring Functions for Docking

    Pham, Tuan A.; Jain, Ajay N.

    2008-01-01

    Empirical scoring functions used in protein-ligand docking calculations are typically trained on a dataset of complexes with known affinities with the aim of generalizing across different docking applications. We report a novel method of scoring-function optimization that supports the use of additional information to constrain scoring function parameters, which can be used to focus a scoring function’s training towards a particular application, such as screening enrichment. The approach combi...

  9. A Comparison between Two Instruments for Assessing Dependency in Daily Activities: Agreement of the Northwick Park Dependency Score with the Functional Independence Measure

    Siv Svensson

    2012-01-01

    Full Text Available Background. There is a need for tools to assess dependency among persons with severe impairments. Objectives. The aim was to compare the Functional Independence Measure (FIM and the Northwick Park Dependency Score (NPDS, in a sample from in-patient rehabilitation. Material and Methods. Data from 115 persons (20 to 65 years of age with neurological impairments was gathered. Analyses were made of sensitivity, specificity, positive predictive value, and negative predictive value. Agreement of the scales was assessed with kappa and concordance with Goodman-Kruskal’s gamma. Scale structures were explored using the Rank-Transformable Pattern of Agreement (RTPA. Content validation was performed. Results. The sensitivity of the NPDS as compared to FIM varied between 0.53 (feeding and 1.0 (mobility and specificity between 0.64 (mobility and 1.0 (bladder. The positive predictive value varied from 0.62 (mobility to 1.0 (bladder, and the negative predictive value varied from 0.48 (bowel to 1.0 (mobility. Agreement between the scales was moderate to good (four items and excellent (three items. Concordance was good, with a gamma of −.856, an asymptotic error (ase of .025, and P<.000. The parallel reliability between the FIM and the NPDS showed a tendency for NPDS to be more sensitive (having more categories when dependency is high. Conclusion. FIM and NPDS complement each other. NPDS can be used as a measure for severely injured patients who are sensitive when there is a high need of nursing time.

  10. Novel Synthesis and Anti-HIV-1 Activity of 2-Arylthio-6-benzyl-2,3-dihydro-1<em>H>-pyrimidin-4-ones (Aryl <em>S>-DABOs)

    Aly, Youssef L.; Pedersen, Erik Bjerreg.; La Colla, Paolo;

    2007-01-01

    The synthesis and the anti-HIV-1 activity of a series of 2-arylthio-6-benzyl-2,3-dihydro-1H-pyrimidin-4-ones (aryl S-DABOs) are reported. These compounds were synthesized via a coupling reaction of the corresponding 6-benzyl-2-thiouracils with aryl iodides in the presence of neocuproine hydrate, ...

  11. Promoting an active form of learning out-of-class via answering online “study questions” leads to higher than expected exam scores in General Biology

    Susan I. Gibson

    2015-01-01

    A rising need for workers in science, technology, engineering and mathematics (STEM) fields has fueled interest in improving teaching within STEM disciplines. Numerous studies have demonstrated the benefits of active learning approaches on student learning outcomes. However, many of these studies have been conducted in experimental, rather than real-life class, settings. In addition, most of these studies have focused on in-class active learning exercises. This study tested the effects of ans...

  12. Credit Scoring Modeling

    Siana Halim

    2014-01-01

    Full Text Available It is generally easier to predict defaults accurately if a large data set (including defaults is available for estimating the prediction model. This puts not only small banks, which tend to have smaller data sets, at disadvantage. It can also pose a problem for large banks that began to collect their own historical data only recently, or banks that recently introduced a new rating system. We used a Bayesian methodology that enables banks with small data sets to improve their default probability. Another advantage of the Bayesian method is that it provides a natural way for dealing with structural differences between a bank’s internal data and additional, external data. In practice, the true scoring function may differ across the data sets, the small internal data set may contain information that is missing in the larger external data set, or the variables in the two data sets are not exactly the same but related. Bayesian method can handle such kind of problem.

  13. Using Momentary Time Sampling to Estimate Minutes of Physical Activity in Physical Education: Validation of Scores for the System for Observing Fitness Instruction Time

    Heath, Edward M.; Coleman, Karen J.; Lensegrav, Tera L.; Fallon, Jennifer A.

    2006-01-01

    The System for Observing Fitness Instruction Time (SOFIT) is a direct observation system specifically developed for use during physical education (PE; McKenzie, 1991; McKenzie, Sallis, & Nader, 1991). The purpose of this study was to validate the estimates of time spent in various physical activity intensities obtained with the paper and pencil…

  14. Orange Juice--From the Tree to the Glass! Second Grade Activity. Schools of California Online Resources for Education (SCORE): Connecting California's Classrooms to the World.

    Ricchiuti, Linda M.

    The goal of this lesson plan is for second-grade students to understand the steps in how food is made and delivered to the grocery store. Students create a play where each person plays a part in the production and distribution of food. The lesson suggests that the class perform the play on parents' night. It provides five activities for students…

  15. Synthesis, characterization, <em>in silicoem> approach and <em>in vitroem> antiproliferative activity of RPF151, a benzodioxole sulfonamide analogue designed from capsaicin scaffold

    Tavares, Mauricio T.; Pasqualoto, Kerly F. M.; van de Streek, Jacco;

    2015-01-01

    ) in order to verify its antiproliferative activity. RPF151 has significantly reduced the growth of HUVEC cells at 10 μM, suggesting that it probably would act on the angiogenesis process. RPF151 can be considered, then, as a promising anticancer lead for designing novel antitumor agents as potential......RPF151, an alkylsulfonamide capsaicin analogue, was synthesized by a simple and efficient one-step methodology. The compound was characterized by 1H and 13C NMR, elemental analysis, IR and melting point. The crystal structure of RPF151 was determined by X-ray powder diffraction and its experimental...

  16. Parâmetros genéticos para escore de umbigo e características de produção em bovinos da raça Nelore Genetics parameters for umbilicus score and production characteristics in Nellore breed beef cattle

    W. Koury Filho

    2003-10-01

    Full Text Available Utilizaram-se 11.310 medidas de escore visual da característica umbigo, medida aos 18 meses em bovinos, para estimar os componentes de variância, a herdabilidade e as correlações genéticas entre escore do umbigo e peso à desmama (PD e ganho de peso da desmama ao sobreano (GP345, utilizando-se modelo animal bi-característica Os escores de umbigo (EU variaram de 1 (mais pendulosos a 5 (mais curtos. Os valores de herdabilidade foram 0,31 (PD, 0,14 (GP345 e 0,29 (EU, e as correlações genéticas foram -0,05 (EU×PD e 0,14 (EU×GP345. A correlação entre avaliação do umbigo de machos e fêmeas foi de 0,80. Conclui-se que a característica umbigo é passível de seleção e que ela não compromete a seleção para melhores PD e GP345.In this study 11,310 visual score measurements of navel characteristic, collected from bovines, were used. Visual scores for navel (NS, ranged from 1 (the longest to 5 (the shortest. Variance components, genetic parameters and genetic correlations between navel characteristic of 18-month old animals and growth characteristics (weaning weight -WW and weight gain from weaning to over year -WG345 were estimated using a two-traits animal model. Heritability estimates were 0.31 (NS abd 0.14 (WG345, and the genetic correlation estimates were: -0.05 (NS×WW and 0.14 (WW×WG345 and the estimated correlation between navel (female ´ navel (male was 0.80. Score navel can be object of selection and selection for shorter navel does not apparently significantly affect animal performance for WW and WG345.

  17. Predictive values at risk of falling in physically active and no active elderly with Berg Balance Scale Valores preditivos para o risco de queda em idosos praticantes e não praticantes de atividade física por meio do uso da Escala de Equilíbrio de Berg

    Gilmar M. Santos

    2011-04-01

    Full Text Available BACKGROUND: The consequences of falls are a major cause of autonomy and independence loss among the elderly. In this context, the Berg Balance Scale (BBS has been widely used to detect the risk of falls in elderly. OBJECTIVE: To evaluate the predictive value of the BBS for fall risk in physically active and inactive elderly subjects. METHODS: The sample included 188 older adults with a mean age of 66 (±9 years. Of these, 91 participated in a regular physical activity program and 96 did not. We analyzed the cut-off scores of 45, 47, 49, 51 and 53 in both groups regarding the sensitivity (S, specificity (Sp, positive predictive value (PPV and negative predictive value (NPV of the test, including the positive likelihood ratio (PLR and negative likelihood ratio (RVN for diagnosing the risk of falls. RESULTS: The mean BBS score was 54.7 in physically active subjects and 50.8 in inactive subjects, which was statistically significant (ρ=0.001. The best cut-off was a score of 49 for physically inactive subjects, with a sensitivity of 91% and a specificity of 92%. On the other hand, the BBS had low sensitivity (from 0 to 15% and high specificity (between 83% and 100% for physically active subjects at the cut-off points analyzed. CONCLUSION: The scale did not achieve sufficient sensitivity to individual differences among physically active older people with higher levels of functional balance ability.CONTEXTUALIZAÇÃO: Umas das principais causas da perda da autonomia e independência do idoso são as consequências geradas pelas quedas. Nesse contexto, a Escala de Equilíbrio de Berg (EEB vem sendo amplamente utilizada para detectar o risco de queda em idosos. Objetivo: Analisar os valores preditivos para o risco de queda em idosos praticantes e não-praticantes de atividade física por meio do uso da EEB. MÉTODOS: Participaram 188 idosos, com média de idade de 66 (±9 anos. Desses, 91 participavam de projetos de atividades físicas, e 96 n

  18. Índice prognóstico de mortalidade BODE e atividade física em doentes pulmonares obstrutivos crônicos BODE prognostic index of mortality and physical activity in chronic obstructive pulmonary patients

    Karen Muriel Simon

    2009-02-01

    Full Text Available INTRODUÇÃO E OBJETIVO: A DPOC é importante causa de mortalidade no mundo. Para predizer a mortalidade em pacientes com doença pulmonar obstrutiva crônica (DPOC, o índice BODE é utilizado e sua pontuação pode ser reduzida com a prática de atividade física. Este estudo objetiva verificar a associação entre o índice BODE com atividade física em indivíduos com DPOC. MÉTODOS: Foi calculado o índice BODE usando as variáveis: distância no teste da caminhada de seis minutos (TC6'; Medical Research Council Dyspnea Score (MRC; índice de massa corpórea (IMC e grau de obstrução ao fluxo aéreo (VEF1. Os indivíduos foram divididos em grupos classificados em ativos fisicamente (AF e inativos fisicamente (IF. O teste do qui-quadrado foi utilizado para testar a independência das variáveis. O teste t foi utilizado para comparar as variáveis TC6', MRC, IMC, VEF1 entre os grupos de indivíduos AF e IF. RESULTADOS E CONCLUSÃO: Em 38 pacientes com moderada e grave obstrução ao fluxo aéreo (36,5 ± 11,9, o valor médio do BODE foi de 4,1 ± 2,1 para o grupo de indivíduos AF; para o grupo de indivíduos IF, o valor médio do BODE foi de 6 ± 2,2. Houve diferença significativa na comparação das variáveis TC6', MRC, BODE entre os grupos. Existiu maior ocorrência de indivíduos que praticam atividade física de se situar nos quartis um e dois e os indivíduos que não praticam atividade física se situarem nos quartis três e quatro. A existência da maior pontuação do BODE para os pacientes com DPOC considerados inativos fisicamente sustenta o conceito geral de que a inatividade aumenta o risco de morte.INTRODUCTION: COPD is an important cause of morbidity and mortality in the world. The BODE is an important predictive index of mortality and its scores can be reduced with the practice of physical activity. OBJECTIVE: To verify the association between BODE and physical activity in patients with chronic obstructive pulmonary disease

  19. A high-resolution computed tomography-based scoring system to differentiate the most infectious active pulmonary tuberculosis from community-acquired pneumonia in elderly and non-elderly patients

    The objective of this study was to use high-resolution computed tomography (HRCT) imaging to predict the presence of smear-positive active pulmonary tuberculosis (PTB) in elderly (at least 65 years of age) and non-elderly patients (18-65 years of age). Patients with active pulmonary infections seen from November 2010 through December 2011 received HRCT chest imaging, sputum smears for acid-fast bacilli and sputum cultures for Mycobacterium tuberculosis. Smear-positive PTB was defined as at least one positive sputum smear and a positive culture for M. tuberculosis. Multivariate logistic regression analyses were performed to determine the HRCT predictors of smear-positive active PTB, and a prediction score was developed on the basis of receiver operating characteristic curve analysis. Of 1,255 patients included, 139 were diagnosed with smear-positive active PTB. According to ROC curve analysis, the sensitivity, specificity, positive predictive value, negative predictive value, false positive rates and false negative rates were 98.6 %, 95.8 %, 78.5 %, 99.8 %, 4.2 % and 1.4 %, respectively, for diagnosing smear-positive active PTB in elderly patients, and 100.0 %, 96.9 %, 76.5 %, 100.0 %, 3.1 % and 0.0 %, respectively, for non-elderly patients. HRCT can assist in the early diagnosis of the most infectious active PTB, thereby preventing transmission and minimizing unnecessary immediate respiratory isolation. (orig.)

  20. A high-resolution computed tomography-based scoring system to differentiate the most infectious active pulmonary tuberculosis from community-acquired pneumonia in elderly and non-elderly patients

    Yeh, Jun-Jun [Ditmanson Medical Foundation Chia-Yi Christian Hospital, Section of Thoracic Imaging, Department of Chest Medicine and Family Medicine, Chiayi City (China); Chia Nan University of Pharmacy and Science, Tainan (China); Meiho University, Pingtung (China); Pingtung Christian Hospital, Pingtung (China); Chen, Solomon Chih-Cheng; Chen, Cheng-Ren [Ditmanson Medical Foundation Chia-Yi Christian Hospital, Department of Medical Research, Chiayi City (China); Yeh, Ting-Chun; Lin, Hsin-Kai; Hong, Jia-Bin; Wu, Bing-Tsang [Ditmanson Medical Foundation Chia-Yi Christian Hospital, Department of Family Medicine, Chiayi City (China); Wu, Ming-Ting [Department of Radiology, Kaohsiung Veterans General Hospital, Section of Thoracic and Circulation Imaging, Kaohsiung (China); School of Medicine, National Yang Ming University, Faculty of Medicine, Taipei (China)

    2014-10-15

    The objective of this study was to use high-resolution computed tomography (HRCT) imaging to predict the presence of smear-positive active pulmonary tuberculosis (PTB) in elderly (at least 65 years of age) and non-elderly patients (18-65 years of age). Patients with active pulmonary infections seen from November 2010 through December 2011 received HRCT chest imaging, sputum smears for acid-fast bacilli and sputum cultures for Mycobacterium tuberculosis. Smear-positive PTB was defined as at least one positive sputum smear and a positive culture for M. tuberculosis. Multivariate logistic regression analyses were performed to determine the HRCT predictors of smear-positive active PTB, and a prediction score was developed on the basis of receiver operating characteristic curve analysis. Of 1,255 patients included, 139 were diagnosed with smear-positive active PTB. According to ROC curve analysis, the sensitivity, specificity, positive predictive value, negative predictive value, false positive rates and false negative rates were 98.6 %, 95.8 %, 78.5 %, 99.8 %, 4.2 % and 1.4 %, respectively, for diagnosing smear-positive active PTB in elderly patients, and 100.0 %, 96.9 %, 76.5 %, 100.0 %, 3.1 % and 0.0 %, respectively, for non-elderly patients. HRCT can assist in the early diagnosis of the most infectious active PTB, thereby preventing transmission and minimizing unnecessary immediate respiratory isolation. (orig.)

  1. ADHD and Disruptive behavior scores – associations with MAO-A and 5-HTT genes and with platelet MAO-B activity in adolescents

    Larsson Jan-Olov

    2008-04-01

    Full Text Available Abstract Background Pharmacological and genetic studies suggest the importance of the dopaminergic, serotonergic, and noradrenergic systems in the pathogenesis of Attention Deficit Hyperactivity Disorder (ADHD and Disruptive Behavior Disorder (DBD. We have, in a population-based sample, studied associations between dimensions of the ADHD/DBD phenotype and Monoamine Oxidase B (MAO-B activity in platelets and polymorphisms in two serotonergic genes: the Monoamine Oxidase A Variable Number of Tandem Repeats (MAO-A VNTR and the 5-Hydroxytryptamine Transporter gene-Linked Polymorphic Region (5-HTT LPR. Methods A population-based sample of twins, with an average age of 16 years, was assessed for ADHD/DBD with a clinical interview; Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL. Blood was drawn from 247 subjects and analyzed for platelet MAO-B activity and polymorphisms in the MAO-A and 5-HTT genes. Results We found an association in girls between low platelet MAO-B activity and symptoms of Oppositional Defiant Disorder (ODD. In girls, there was also an association between the heterozygote long/short 5-HTT LPR genotype and symptoms of conduct disorder. Furthermore the heterozygote 5-HTT LPR genotype in boys was found to be associated with symptoms of Conduct Disorder (CD. In boys, hemizygosity for the short MAO-A VNTR allele was associated with disruptive behavior. Conclusion Our study suggests that the serotonin system, in addition to the dopamine system, should be further investigated when studying genetic influences on the development of Disruptive Behavior Disorders.

  2. Assessment of Disease Activity in Small Bowel Crohn’s Disease: Comparison between Endoscopy and Magnetic Resonance Enterography Using MRIA and Modified MRIA Score

    Arnaldo Scardapane; Annalisa Ambrosi; Emanuela Salinaro; Maria Elisabetta Mancini; Mariabeatrice Principi; Alfredo Di Leo; Filomenamila Lorusso; Amato Antonio Stabile Ianora; Giuseppe Angelelli

    2015-01-01

    Objectives. To retrospectively compare the results of the MRIA (magnetic resonance index of activity) with a modified MRIA (mMRIA), which was calculated excluding from MRIA formula the data of relative contrast enhancement (RCE). Materials and Methods. MR-E and corresponding endoscopic records of 100 patients were reviewed. MRIA, mMRIA, and SES endoscopic index were calculated for all the patients. Namely, MRIA was calculated as follows: (1.5 × wall thickening + 0.02 × RCE + 5 × intramural ed...

  3. Eficácia de intervenção com enoxaparina baseada em sistema de pontuação nos desfechos perinatais de gestantes com trombofilias Usefulness of a scoring system on perinatal outcomes in pregnant women with thrombophilia in the effectiveness of an enoxaparin-based intervention

    Ernesto Antonio Figueiró-Filho

    2012-10-01

    Full Text Available OBJETIVO: Avaliar se a intervenção com heparina de baixo peso molecular (HBPM - enoxaparina sódica - foi eficaz na melhora dos desfechos perinatais de mulheres com trombofillias com base em sistema de pontuação. MÉTODOS: Estudo prospectivo, não randomizado, não controlado, realizado em um Ambulatório de Gestação de Alto Risco, durante o período de novembro de 2009 a novembro de 2011. Foram incluídas gestantes com diagnóstico e intervenção terapêutica para trombofilias adquiridas e/ou hereditárias na gestação atual. Os dados obstétricos e perinatais das gestantes anteriores à intervenção foram comparados com os desfechos subsequentes à intervenção, sendo analisados estatisticamente através do teste do χ², com correção de Yates, considerando significativos quando pPURPOSES: To assess whether an enoxaparin-based intervention using a score system was effective in improving perinatal outcome in women with thrombophilia. METHODS: Study Design: Prospective, not randomized, uncontrolled, performed at a Clinic of High-Risk Pregnancy from November 2009 to November 2011. We included women with a diagnosis and therapeutic intervention for thrombophilia acquired and/or inherited in the current pregnancy. The obstetric and perinatal outcomes of pregnant women before the intervention were compared with outcomes after the intervention, and statistically analyzed using the χ2 test with Yates correction, considered significant when p<0.05. The initial dose of low-molecular-weight Heparin (LMWH was guided by a scoring system based on the clinical and gestational history of the patients and screening tests for acquired and/or inherited thrombophilia. RESULTS: We included 84 pregnant women with 175 pregnancies before diagnosis, 20.0% of which resulted in fetal ou perinatal death, 40.0% resulted in abortion, 17.7% developed preeclampsia/eclampsia, 10.3% resulted in full-term births, and 29.7% in premature births. In the 84 pregnancies

  4. O uso do custeio baseado em atividades: ABC (Activity Based Costing nas maiores empresas de Santa Catarina

    Ilse Maria Beuren

    2002-12-01

    Full Text Available Devido à globalização da economia, as empresas evoluíram para a produção de enormes variedades de produtos personalizados. Com o intuito de atender às exigências dos clientes, surgiu a necessidade de grandes alterações nos processos tecnológicos. Como conseqüência, os custos indiretos passaram a ser mais significativos, o que implicou um novo método de distribuição desses custos, capaz de distribuir melhor os custos indiretos aos produtos e serviços. A esse método foi dado o nome de custeio baseado em atividades - ABC (Activity Based Costing. Esse método foi investigado por Carlos Yorghi Khoury em 1996, numa pesquisa aplicada às 500 maiores empresas do Brasil. O objetivo deste trabalho foi replicar essa pesquisa nas maiores empresas catarinenses, a fim de observar se esses resultados obtidos assemelham-se aos obtidos na pesquisa com as empresas catarinenses.Nesta pesquisa, dos 200 questionários enviados para as maiores empresas de Santa Catarina, 81 retornaram com as questões respondidas. O trabalho levou a conclusões importantes, como: as empresas de Santa Catarina têm amplo conhecimento do sistema ABC; algumas empresas que implantaram esse sistema já estão desistindo de seu uso, em função da complexidade para apropriar os custos indiretos e as despesas às atividades e estas aos produtos.Due to the economic globalization, enterprises have started to produce enormous varieties of personalized products. In order to attend to the requirements of their clients, huge changes in the technological process were needed. Consequently, indirect costs became more significant, which led to a new method for distributing the indirect costs, capable of better distributing the indirect costs of products and services.This method was called Activity Based Costing and was investigated by Carlos Yorghi Khoury in 1996 through a research applied in the 500 biggest companies in Brazil. This paper aims to replicate the 1996 research in the

  5. Short and Long-Term Effects of <em>Baccharis articulataem> on Glucose Homeostasis

    Flávio H. Reginatto

    2012-06-01

    Full Text Available In this study, the<em> in vivoem> effect of the crude extract and <em>n>-butanol and aqueous residual fractions of <em>Baccharis articulataem> (Lam. Pers. on serum glucose levels, insulin secretion and liver and muscle glycogen content, as well as<em> in vitroem> action on serum intestinal disaccharidase activity and albumin glycation were investigated. Oral administration of the extract and fractions reduced glycemia in hyperglycemic rats. Additionally, the <em>n>-butanol fraction, which has high flavonoids content, stimulated insulin secretion, exhibiting an insulinogenic index similar to that of glipizide. Also, the <em>n>-butanol fraction treatment significantly increased glycogen content in both liver and muscle tissue. <em>In vitroem> incubation with the crude extract and <em>n>-butanol and aqueous residual fractions inhibited maltase activity and the formation of advanced glycation end-products (AGEs. Thus, the results demonstrated that <em>B. articulataem> exhibits a significant antihyperglycemic and insulin-secretagogue role. These effects on the regulation of glucose homeostasis observed for <em>B. articulataem> indicate potential anti-diabetic properties.

  6. Credit Scores and College Investment

    Nicole Simpson; Felicia Ionescu

    2010-01-01

    The private market of student loans has become an important source of college financing in the U.S. Unlike government student loans, the terms on private student loans (i.e., credit limits and interest rates) are based on credit scores We quantify the effects of credit scores on college investment in a heterogeneous life-cycle economy that exhibits a government and private market for student loans. We find that students with higher credit scores invest in more college education. Furthermore, ...

  7. Estudo comparativo entre o teste do pH e do KOH versus escore de Nugent para diagnóstico da vaginose bacteriana em gestantes Comparative study between the pH test and of the KOH versus Nugent score for diagnosis of bacterial vaginosis in pregnant women

    Ana Aurélia Salles Campos

    2012-05-01

    Full Text Available OBJETIVO: Aquilatar a prevalência da vaginose bacteriana e comparar a acurácia dos testes do pH e do KOH com o gradiente de Nugent, método padrão-ouro, no diagnóstico da vaginose bacteriana (VB em gestantes assintomáticas e sintomáticas de baixo risco. MÉTODOS: Foi realizado um estudo de corte transversal em 321 grávidas, com idade gestacional entre 14ª e 26ª semanas, 218 assintomáticas e 103 com queixa de secreção vaginal sugestiva de vaginose bacteriana. Todas as gestantes foram avaliadas pelos critérios de Nugent e submetidas à pHmetria vaginal e ao teste do KOH a 10%. O coeficiente de Kappa foi utilizado para avaliar os métodos quanto à concordância diagnóstica. RESULTADO: A maioria das gestantes era adolescente (média etária 21,0±5,6 anos, nulípara e parda. A prevalência da vaginose bacteriana foi de 33,3% pelo método de pH e KOH e de 35,5% pelo Nugent. Entre as grávidas assintomáticas, foi observada ótima concordância dos métodos, com 72,5% delas apresentando resultados negativos para ambos os métodos, o que resultou em um elevado coeficiente de Kappa (k=0,82. No grupo de gestantes sintomáticas, houve 49,5% de positividade para ambos os métodos diagnósticos, demonstrando ótima concordância (k=0,74. CONCLUSÃO: A prevalência da vaginose bacteriana foi elevada tanto pelo método de pH e KOH quanto pelo Nugent. O método do pH e KOH é tão capaz em diagnosticar a vaginose bacteriana quanto os critérios de Nugent.PURPOSE: To assess the prevalence of bacterial vaginosis and to compare the accuracy of testing pH and KOH with the Nugent gradient, the gold standard for the diagnosis of bacterial vaginosis (BV in asymptomatic and symptomatic pregnant women at low risk. METHODS: We conducted a cross-sectional study on 321 pregnant women with gestational age between 14 and 26 weeks, 218 of them asymptomatic and 103 with vaginal complaints suggestive of bacterial vaginosis. All women were assessed by the

  8. Confidence scores for prediction models

    Gerds, Thomas Alexander; van de Wiel, MA

    2011-01-01

    distinguish rival prediction models with similar prediction performances. Furthermore, on the subject level a confidence score may provide useful supplementary information for new patients who want to base a medical decision on predicted risk. The ideas are illustrated and discussed using data from cancer...... modelling strategy is applied to different training sets. For each modelling strategy we estimate a confidence score based on the same repeated bootstraps. A new decomposition of the expected Brier score is obtained, as well as the estimates of population average confidence scores. The latter can be used to...

  9. Validação do escore de Alvarado no diagnóstico de apendicite aguda em crianças e adolescentes no Instituto Materno Infantil de Pernambuco, IMIP The Alvarado score validation in diagnosing acute appendicitis in children and teenagers at the Instituto Materno Infantil de Pernambuco, IMIP

    Paulo Sérgio Gomes Nogueira Borges

    2003-12-01

    Full Text Available OBJETIVOS: determinar a acurácia do escore de Alvarado para o diagnóstico de apendicite aguda em crianças e adolescentes admitidos na emergência do Instituto Materno Infantil de Pernambuco (IMIP. MÉTODOS: foi realizado um estudo de validação de método diagnóstico (escore clínico-laboratorial para diagnóstico de apendicite aguda tendo o exame histopatológico como padrão ouro. A amostra estudada consistiu de 81 crianças e adolescentes, admitidas na emergência pediátrica do IMIP com dor abdominal suspeita de apendicite aguda, no período de março a outubro de 2002. Os pacientes foram atendidos na emergência pediátrica e avaliados quanto ao escore de Alvarado. Entretanto a decisão cirúrgica foi tomada pelo cirurgião responsável. RESULTADOS: tomando como ponto de corte o valor >5 pontos, encontramos uma sensibilidade de 92,6%, especificidade 63,6%, valor preditivo positivo de 86,2% e valor preditivo negativo de 77,8%. CONCLUSÕES: o escore de Alvarado é um procedimento pouco invasivo, simples, rápido, reprodutível, que utilizando o ponto de corte >5 pontos apresenta-se como instrumento de alto valor na triagem de crianças e adolescentes com suspeita diagnóstica de apendicite aguda.OBJECTIVES: to determine the accuracy of the Alvarado score in diagnosing acute appendicitis in children and adolescents admitted in the emergency unit of the Instituto Materno Infantil de Pernambuco (IMIP. METHODS: a diagnostic test study was carried out (clinical and laboratory score to diagnose acute appendicitis using histopathology exam as the golden standard. The sample studied consisted of 81 children and adolescents admitted in the pediatrics emergency unit of IMIP with symptoms and signs consistent with clinical suspicion of acute appendicitis from the period of March to October 2002. Patients were examined in the pediatric emergency and assessed by the Alvarado score. Nevertheless, the decision to whether or not perform the surgery was

  10. Role of physical activity on the maintenance of cognition and activities of daily living in elderly with Alzheimer's disease Papel da atividade física na manutenção da cognição e atividades de vida diária em idosos com doença de Alzheimer

    Cynthia Arcoverde

    2008-06-01

    Full Text Available BACKGROUND: The practice of physical activities has proved to be an efficient strategy in the improvement of independency and cognitive functions in the elderly with Alzheimer's disease (AD. OBJECTIVE: To evaluate the relation between the practice of physical activity, cognition and activities of daily living (ADL of patients with AD. METHOD: The cognitive and physical aspects and ADL were evaluated of 37 elders (19 normal controls, 11 sedentary with AD and 7 active with AD. RESULTS: The variable that best predicts the cognitive state (MMSE is the duration of disease for the AD sedentary group and Lawton's Scale for the AD active group. We observed a correlation between MMSE score and duration of disease in the sedentary group and between MMSE and ADL in the active group. CONCLUSION: Our study showed that physical and cognitive stimulation in patients with AD can contribute to decrease cognitive and functional decline.FUNDAMENTO: A prática de atividade física tem se mostrado uma estratégia eficaz na melhora da independência e das funções cognitivas em idosos com doença de Alzheimer (DA. OBJETIVO: Avaliar a relação entre a prática de atividade física, a cognição e as atividades de vida diária (AVD em pacientes com DA. MÉTODO: Foram avaliados os aspectos cognitivos, físicos e as AVD de 37 idosos (19 controles normais, 11 com DA sedentários e 7 com DA ativos. RESULTADOS: A variável que melhor prediz o estado cognitivo (MEEM foi o tempo de doença para o grupo DA sedentários e a Escala de Lawton para o grupo DA ativo. Observou-se correlação entre MEEM e tempo de doença no grupo sedentário e MEEM e AVD no grupo ativo. CONCLUSÃO: O nosso estudo mostrou que a estimulação física e cognitiva em pacientes com DA pode contribuir na diminuição do declínio cognitivo e funcional.

  11. The Machine Scoring of Writing

    McCurry, Doug

    2010-01-01

    This article provides an introduction to the kind of computer software that is used to score student writing in some high stakes testing programs, and that is being promoted as a teaching and learning tool to schools. It sketches the state of play with machines for the scoring of writing, and describes how these machines work and what they do.…

  12. Interpreting Linked Psychomotor Performance Scores

    Looney, Marilyn A.

    2013-01-01

    Given that equating/linking applications are now appearing in kinesiology literature, this article provides an overview of the different types of linked test scores: equated, concordant, and predicted. It also addresses the different types of evidence required to determine whether the scores from two different field tests (measuring the same…

  13. Estimativas de correlações genéticas entre escores visuais e características de carcaça medidas por ultrassonografia em bovinos Nelore utilizando modelos bayesianos linear-limiar Genetic correlation estimates between visual scores and carcass traits measured by ultrasound in Nelore cattle using linear-threshold bayesian models

    Carina Ubirajara de Faria

    2009-11-01

    Full Text Available O objetivo neste estudo foi estimar as correlações genéticas entre escores visuais e características de carcaça medidas por ultrassonografia em bovinos da raça Nelore utilizando a estatística bayesiana por meio da Amostragem de Gibbs, sob modelo animal linear-limiar. Foram estudadas as características categóricas morfológicas de musculosidade, estrutura física, conformação e sacro, avaliadas aos 15 e 22 meses de idade. Para as características de carcaça, foram avaliadas as características área de olho-de-lombo, espessura de gordura subcutânea, espessura de gordura subcutânea na garupa e altura na garupa. Os escores visuais devem ser empregados como critérios de seleção para aumentar o progresso genético para a característica área de olhode-lombo e, consequentemente, melhorar o rendimento de carcaça. As estimativas de correlação genética obtidas para musculosidade com espessura de gordura subcutânea e espessura de gordura subcutânea na garupa indicaram que a seleção para musculosidade pode levar a animais com melhor acabamento de carcaça. A seleção para a estrutura física e conformação aos 15 e 22 meses de idade pode promover resposta correlacionada para o aumento da altura na garupa.The objective of this study was to estimate the genetic correlations between visual scores and the carcass traits measured by ultrasound, in Nellore breed cattle, using the bayesian statistics by Gibbs Sampling, in the linear-threshold model. The morphological categorical traits of musculature, physical structure, conformation and sacrum were studied, evaluated at 15 and 22 months. The carcass traits of the longissimus muscle area, backfat thickness, rump fat thickness and hip height were evaluated. Visual scores should be used as selection criterion to increase genetic progress for the longissumus muscle area. The estimates of genetic correlations obtained between musculature and backfat thickness and rump fat thickness

  14. Atividade da redutase do nitrato em folhas de cafeeiro em função da adubação nitrogenada = Nitrate reductase activity on coffee leaves in relation to nitrogen supply

    André Rodrigues dos Reis

    2007-04-01

    Full Text Available A redutase de nitrato (RN é a primeira enzima no processo de redução do nitrogênio na planta. Sua incorporação, em esqueletos carbônicos, pode melhor indicar a entrada do nitrogênio na planta. O objetivo deste trabalho foi avaliar o efeito de diferentes doses e épocas de aplicação de nitrogênio sobre a atividade da RN e estabelecer correlações com a produtividade do cafeeiro. O delineamento experimental utilizado foi de blocos ao acaso, em esquema fatorial 5 x 3 x 3, constituído pela combinação de 5 doses (0, 50, 150, 250e 350 kg ha-1 de N; 3 épocas de aplicação (aplicação única em dezembro, 2 aplicações (parceladas em novembro e janeiro e 3 aplicações (parceladas em novembro, dezembro e janeiro e atividade da enzima em três posições na planta (ápice, terço médio e base.Avaliou-se a produtividade do cafeeiro, teor de nitrogênio foliar, além da atividade da RN durante a fase de frutificação. A atividade da enzima correlacionou-se positivamente tanto com o teor de N foliar (r = 0,96 quanto na produtividade de grãos (r = 0,89, ajustando-sea uma função linear e quadrática, respectivamente. A maior produtividade de grãos foi obtida com o fornecimento de 210 kg ha-1 de N.The nitrate reductase (RN is the first enzyme in the nitrogen reduction process on crops incorporated to carbonic skeletons that can indicate the nitrogen entrance level on plants. This work aims to investigate the effects of different rates and times of nitrogenapplication on RN activity and nitrogen content in leaves; and to establish correlations with coffee plants productivity. The experimental design used was completely randomized in a factorial outline 5 x 3 x 3, constituted by the combination of 5 nitrogen(urea rates (0, 50, 150, 250 and 350 kg ha-1 in three application times (a single application in December; two applications (November and January; three applications (November, December and January and enzyme activity on three plant

  15. Determinação de escore e nota de corte do módulo de asma do International Study of Asthma and Allergies in Childhood para discriminação de adultos asmáticos em estudos epidemiológicos Determining the score and cut-off point that would identify asthmatic adults in epidemiological studies using the asthma module of the International Study of Asthma and Allergies in Childhood questionnaire

    Elayne de Fátima Maçãira

    2005-12-01

    Full Text Available OBJETIVO: Validar o questionário padronizado escrito do International Study of Asthma and Allergies in Childhood, módulo sobre asma, para pesquisa de prevalência de asma, estabelecendo seu escore e a nota de corte para discriminação de adultos asmáticos. MÉTODOS: Entrevistamos pacientes ambulatoriais adultos, 40 asmáticos e 38 controles, pareados por sexo e idade, utilizando o módulo de asma do International Study of Asthma and Allergies in Childhood, composto por oito aspectos dicotômicos de asma. Determinamos o escore e a nota de corte para discriminação de asmáticos, definindo sua sensibilidade, especificidade e índice de Youden. Validamos o método em contraposição ao diagnóstico clínico e funcional. A reprodutibilidade das questões individuais foi testada por meio de reentrevistas de metade dos pacientes após algumas semanas. RESULTADOS: O escore variou de 0 a 14 pontos. Um escore = 5 pontos permitiu discriminar pacientes asmáticos (sensibilidade = 93%, especificidade = 100% e índice de Youden = 0,93. A maioria das questões apresentou boa reprodutibilidade, observada em reentrevista após 48,2 ± 11,1 dias (Kappa e Kappa ponderado variando de 0,43 a 1,00 para as questões individuais. CONCLUSÃO: A validação de uma nota de corte permite uma interpretação alternativa às informações fornecidas pelo módulo de asma do International Study of Asthma and Allergies in Childhood, levando em conta o conjunto das informações e não somente as respostas individuais de cada questão em estudos de prevalência de asma em adultos.OBJECTIVE: To validate, for use in asthma prevalence studies, the asthma module of the standardized written questionnaire developed for use in the International Study of Asthma and Allergies in Childhood, establishing the score and cut-off point that would identify asthmatic adults. METHODS: We interviewed 78 adult outpatients (40 adult asthmatics and 38 age-matched and gender-matched controls

  16. Synthesis of 1,2,3-Triazole Derivatives and <em>in Vitroem> Antifungal Evaluation on <em>Candida> Strains

    Almir G. Wanderley

    2012-05-01

    Full Text Available 1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1<em>H>-1,2,3-triazol-4-ylpropan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or <em>click chemistryem>. Next the<em> in vitroem> antifungal activity of these ten compounds was evaluated using the microdilution broth method against 42 isolates of four different <em>Candida> species. Among all tested compounds, the halogen substituted triazole 2-[1-(4-chlorophenyl-1<em>H>-(1,2,3triazol-4-yl]propan-2-ol, revealed the best antifungal profile, showing that further modifications could be done in the structure to obtain a better drug candidate in the future.

  17. Occipital intermittent rhythmic delta activity in absence epilepsy Atividade occipital delta rítmica intermitente em epilepsia ausência

    Laura M.F.F. Guilhoto

    2006-06-01

    Full Text Available Occipital intermittent rhythmic delta activity (OIRDA is considered good prognostic factor in typical absences (TA. We report electroclinical evolution in 14 patients with TA and OIRDA, which performed video-EEG. Seven patients were female; 9 had childhood absence epilepsy and the others did not present electroclinical characteristics for syndromic classification according to ILAE's classification (1989. Pyknolepsy was referred to in 13; TA was the only seizure type in 13; one had generalized tonic-clonic seizures (GTCS and three had myoclonic jerks during TA. VPA monotherapy controlled seizures in 11, diVPA and ESM, in one each. After seizure control EEG normalized in 10 while in three, spike-wave complexes (SWC persisted, accompanied by OIRDA in one. Finally in another, seizures were not controlled and SWC and OIRDA persisted. In conclusion, we observed in this series of TA and OIRDA with onset before 10 years, pyknolepsy as common finding and few GTCS. VPA controlled seizures in most cases and EEG normalized in 76.92%. We suggest that OIRDA could be considered good prognostic factor in TA associated with SWC and of epileptiform nature leading to appropriate investigation.Atividade occipital delta rítmica intermitente (AODRI é considerada fator de bom prognóstico em crises de ausência típica (AT. Neste estudo relatamos a evolução eletroclínica de 14 pacientes com AT e AODRI que realizaram vídeo-EEG. Sete pacientes eram do sexo feminino; nove tinham epilepsia ausência da infância e os outros não apresentavam características eletroclínicas para classificação sindrômica de acordo com a classificação da ILAE (1989. Picnolepsia foi relatada em 13; AT foi o único tipo de crise em 13; um tinha crises generalizadas TCG e três, abalos mioclônicos durante AT. Monoterapia com VPA controlou as crises em 11, diVPA e ESM, em um cada. Após o controle das crises, o EEG normalizou em 10; em três, complexos de espícula-onda (CEO

  18. Correlation of the National Board of Medical Examiners Emergency Medicine Advanced Clinical Examination given in July to intern American Board of Emergency Medicine in-training examination scores, a predictor of performance?

    Katherine Hiller

    2015-11-01

    Full Text Available Introduction: There is great variation in the knowledge base of Emergency Medicine (EM interns in July. The first objective knowledge assessment during residency does not occur until eight months later, in February, when the American Board of EM (ABEM administers the in-training examination (ITE. In 2013, the National Board of Medical Examiners (NBME released the EM Advanced Clinical Examination (EM-ACE, an assessment intended for fourth-year medical students. Administration of the EM-ACE to interns at the start of residency may provide an earlier opportunity to assess the new EM residents’ knowledge base. The primary objective of this study was to determine the correlation of the NBME EM-ACE, given early in residency, with the EM ITE. Secondary objectives included determination of the correlation of the United States Medical Licensing Examination (USMLE Step 1 or 2 scores with early intern EM-ACE and ITE scores and the effect, if any, of clinical EM experience on examination correlation. Methods: This was a multi-institutional, observational study. Entering EM interns at six residencies took the EM-ACE in July 2013 and the ABEM ITE in February 2014. We collected scores for the EMACE and ITE, age, gender, weeks of clinical EM experience in residency prior to the ITE, and USMLE Step 1 and 2 scores. Pearson’s correlation and linear regression were performed. Results: Sixty-two interns took the EM-ACE and the ITE. The Pearson’s correlation coefficient between the ITE and the EM-ACE was 0.62. R-squared was 0.5 (adjusted 0.4. The coefficient of determination was 0.41 (95% CI [0.3-0.8]. For every increase of one in the scaled EM-ACE score, we observed a 0.4% increase in the EM in-training score. In a linear regression model using all available variables (EM-ACE, gender, age, clinical exposure to EM, and USMLE Step 1 and Step 2 scores, only the EM-ACE score was significantly associated with the ITE (p<0.05. We observed significant colinearity

  19. Efeito do cobre na atividade da enzima pirogalol peroxidase em plantas de Myriophyllum aquaticum cultivadas em solução nutritiva Effect of copper on the activity of pirogalol peroxidase in Myriophyllum aquaticum plants cultivated in nutritives solution

    V.D. Domingos

    2005-06-01

    Full Text Available Myriophyllum aquaticum é uma planta perene, herbácea, que pode se desenvolver totalmente submersa ou com a porção terminal dos ramos acima da superfície da água. É também considerada uma planta daninha que possui elevado potencial de colonização, o qual, dependendo da densidade populacional, pode causar aumento no teor de matéria orgânica e redução de oxigênio na água, comprometendo a qualidade da água e seus usos múltiplos. O objetivo do presente trabalho foi verificar a influência do cobre na atividade da pirogalol peroxidase de plantas de M. aquaticum submetidas à solução nutritiva contendo concentrações de cobre de 1,2; 11,2; 21,2; 31,2; e 41,2 µg L-1. O experimento foi conduzido em um delineamento experimental inteiramente casualizado, com quatro repetições e cinco tratamentos, aos quais as plantas foram submetidas durante 21 dias. Aos 81 dias após a instalação das mudas em solução nutritiva contendo os diferentes níveis de cobre, as folhas foram colhidas a partir do ápice da planta até o final do ramo, que não estavam em contato com a solução. Esse material fresco foi envolvido por plástico transparente e papel-alumínio e, a seguir, congelado em nitrogênio líquido, sendo armazenado em freezer a -20 ºC até o momento da determinação da atividade da enzima pirogalol peroxidase. A atividade da enzima foi progressiva com o aumento das doses de cobre. As plantas cultivadas com 40 µg L-1 de Cu2+ após três semanas, com base em avaliação visual, apresentaram redução no desenvolvimento.Myriophyllum aquaticum is a perennial, herbaceous plant which grows totally submerged or with the terminal portion of the branches above the surface of the water. It is also considered to be a harmful plant, possessing a high colonization potential which, depending on population density, can increase the organic matter content and reduce oxygen in the water, compromising the quality of water and its multiple uses

  20. Different contributions of HtrA protease and chaperone activities to <em>Campylobacter jejuniem> stress tolerance and physiology

    Bæk, Kristoffer Torbjørn; Vegge, Christina Skovgaard; Skórko-Glonek, Joanna;

    2011-01-01

    A chaperone activity is sufficient for growth at high temperature or oxidative stress, whereas the HtrA protease activity is only essential at conditions close to the growth limit for C. jejuni. However, the protease activity was required to prevent induction of the cytoplasmic heat-shock response even at...

  1. 5-(5-Aryl-1,3,4-oxadiazole-2-carbonylfuran-3-carboxylate and New Cyclic <em>C>-Glycoside Analogues from Carbohydrate Precursors with MAO-B, Antimicrobial and Antifungal Activities

    Nagwa Said Abd El-Dayem

    2012-06-01

    Full Text Available Cyclization of acyclic <em>C>-glycoside derivatives 1a,b to 2a,b as the major isomers, and 4a,b as the minor isomers were carried out. The isopropylidene derivatives 3a,b were prepared, as well as the hydrazide derivative 6, which was condensed with a variety of aldehydes to give hydrazones 7a–e which were also prepared from the compounds 12a–e. Acetylation of 7a,d gave the corresponding acetyl derivatives 8a,d, respectively. In addition, the dicarbonyl compound 9 was prepared in the hydrate form, which reacted with a number of aroylhydrazines to give the corresponding bisaroyl-hydrazones 10a–d, which were cyclized into 1,3,4-oxadiazoles 11a–d. Furthermore, two of the prepared compounds were examined to show the ability to activate MAO-B. In addition a number of prepared compounds showed antibacterial and antiviral activities.

  2. Reguladores vegetais e atividade de invertases em cana-de-açúcar em meio de safra Growth regulators and activity invertases in the middle of the cropping season

    Glauber Henrique Pereira Leite

    2009-06-01

    Full Text Available O objetivo neste trabalho foi a avaliação da atividade das invertases ácida e neutra e a função que essas exercem no controle do acúmulo de sacarose em cana-de-açúcar, variedade SP80-3280, decorrente da aplicação de reguladores vegetais no meio de safra, em Igaraçu do Tietê (SP. O experimento foi conduzido em cana soca, em safras consecutivas (2004 e 2005. O delineamento experimental utilizado foi em blocos casualizados, com cinco repetições. Os tratamentos foram constituídos da aplicação de quatro reguladores vegetais da classe dos retardadores do crescimento (Etefon, Etil-trinexapac, KNO3 e KNO3 + Boro e uma testemunha (maturação natural, comercialmente encontrados como Ethrel, Moddus, Krista Kana e Krista Kana Plus, respectivamente, adotando-se a dosagem do produto comercial: 2L ha-1, 0,8L ha-1, 3kg ha-1 e 3kg ha-1, respectivamente, sem a adição de adjuvantes. Os reguladores vegetais promovem alterações de intensidades distintas e significativas nos níveis enzimáticos das invertases ácida e neutra. A eficiência agronômica dos maturadores foi afetada de forma significativa pelo clima e pela época de aplicação. Os tratamentos com maturadores, principalmente em 2004, cujas condições climáticas foram desfavoráveis à maturação natural, favoreceram o processo de maturação da cana-de-açúcar, implicando em melhorias da qualidade tecnológica dos colmos.The objective of this research was to evaluate the activity of acid and neutral invertases in controling the storage of sucrose in sugarcane variety SP80-3280 due to plant regulators application in the middle of the cropping season in Igaraçu do Tietê (SP, Brazil. The experiment was carried out in ratoon cane (crop 2004 and 2005 in a randomized block design with five replications. The treatments consisted of four plant regulators application of the class of growth retainers (Ethephon, Ethyl.trinexapac, Potassium nitrate and Potassium nitrate + Boron and a

  3. Rationale and study protocol for the supporting children’s outcomes using rewards, exercise and skills (SCORES group randomized controlled trial: A physical activity and fundamental movement skills intervention for primary schools in low-income communities

    Lubans David R

    2012-06-01

    Full Text Available Abstract Background Many Australian children are insufficiently active to accrue health benefits and physical activity (PA levels are consistently lower among youth of low socio-economic position. PA levels decline dramatically during adolescence and evidence suggests that competency in a range of fundamental movement skills (FMS may serve as a protective factor against this trend. Methods/design The Supporting Children’s Outcomes Using Rewards Exercise and Skills (SCORES intervention is a multi-component PA and FMS intervention for primary schools in low-income communities, which will be evaluated using a group randomized controlled trial. The socio-ecological model provided a framework for the 12-month intervention, which includes the following components: teacher professional learning, student leadership workshops (including leadership accreditation and rewards, e.g., stickers, water bottles, PA policy review, PA equipment packs, parental engagement via newsletters, FMS homework and a parent evening, and community partnerships with local sporting organizations. Outcomes will be assessed at baseline, 6- and 12-months. The primary outcomes are PA (accelerometers, FMS (Test of Gross Motor Development II and cardiorespiratory fitness (multi-stage fitness test. Secondary outcomes include body mass index [using weight (kg/height (m2], perceived competence, physical self-esteem, and resilience. Individual and environmental mediators of behavior change (e.g. social support and enjoyment will also be assessed. The System for Observing Fitness Instruction Time will be used to assess the impact of the intervention on PA within physical education lessons. Statistical analyses will follow intention-to-treat principles and hypothesized mediators of PA behavior change will be explored. Discussion SCORES is an innovative primary school-based PA and FMS intervention designed to support students attending schools in low-income communities to be more skilled

  4. Freqüência da atividade sexual em mulheres menopausadas Factors related to frequency of sexual activity of postmenopausal women

    Dino Roberto Soares De Lorenzi

    2006-08-01

    Full Text Available OBJETIVO: Identificar os fatores relacionados à freqüência da atividade sexual entre mulheres pós-menopáusicas. MÉTODOS: Estudo transversal de 206 mulheres pós-menopáusicas entre 45 e 60 anos atendidas em um serviço universitário da região Sul do Brasil entre junho e outubro de 2002. A atividade sexual foi avaliada pelo número de relações sexuais no último mês e a sintomatologia climatérica pelo Índice de Kupperman. Na análise estatística, fez-se regressão linear múltipla. RESULTADOS: Das mulheres pesquisadas, 176 (85% eram sexualmente ativas. Cerca de 60,6% relataram diminuição da atividade sexual após a menopausa, o que atribuíram principalmente à impotência sexual do parceiro (41,7%. Aproximadamente 25,7% negaram satisfação com o intercurso sexual. Na análise por regressão linear múltipla, associaram-se à atividade sexual a idade (pOBJECTIVE: To identify factors related to the frequency of sexual activity of postmenopausal women METHODS: A cross-section study of 206 postmenopausal women between 45 and 60 years of age was made at a university health care service in the South of Brazil between June and October 2002. Evaluations were made of sexual activity according to the number of sexual intercourses in the previous month and the climacteric symptoms using the Kupperman index. Statistical analysis was performed with multiple linear regression analysis. RESULTS: Of those surveyed 176 (85% women were sexually active. Although 60.6% reported a decrease in sexual activity after menopause, mostly attributing it to the husband's sexual impotence (41.7%. Approximately 25.7% stated they had no satisfaction with sexual intercourse. By means of multiple linear regression analysis the following aspects were associated to sexual activity: age (p<0.1, degree of sexual satisfaction (p=0.01, and climacteric symptomatology (p=0.02. As age increased the climacteric symptoms were more intense and sexual activity was less

  5. Bishop score and labor induction

    Radeka Gordana; Novakov-Mikić Aleksandra; Ivanović Ljiljana

    2002-01-01

    Introduction Induction of labor represents initiation of uterine contractions before their spontaneous onset. The aim of the study was to establish the role of Bishop score in prediction of labor induction in routine clinical work. Material and methods The study was a prospective blind, observational one. All patients had a vaginal examination prior to induction, during which Bishop score was evaluated. The mode of induction was either intravenous infusion of oxytocin or endovaginal prostagla...

  6. Stability Scores: Measuring Coalitional Stability

    Feldman, Michal; Meir, Reshef; Tennenholtz, Moshe

    2011-01-01

    We introduce a measure for the level of stability against coalitional deviations, called \\emph{stability scores}, which generalizes widely used notions of stability in non-cooperative games. We use the proposed measure to compare various Nash equilibria in congestion games, and to quantify the effect of game parameters on coalitional stability. For our main results, we apply stability scores to analyze and compare the Generalized Second Price (GSP) and Vickrey-Clarke-Groves (VCG) ad auctions....

  7. From Rasch scores to regression

    Christensen, Karl Bang

    2006-01-01

    Rasch models provide a framework for measurement and modelling latent variables. Having measured a latent variable in a population a comparison of groups will often be of interest. For this purpose the use of observed raw scores will often be inadequate because these lack interval scale propertie....... This paper compares two approaches to group comparison: linear regression models using estimated person locations as outcome variables and latent regression models based on the distribution of the score....

  8. Anatomy of Credit Scoring Models

    Matías Alfredo Gutiérrez Girault

    2008-01-01

    Introduced in the 70´s, the use of credit scoring techniques became widespread in the 90´s thanks to the development of better statistical and computational resources. Nowadays almost all the financial intermediaries use these techniques, at least to originate the credits they grant. Credit scoring models are algorithms that in a mechanical way assess the credit risk of a loan applicant or an existing bank client, by means of statistical, mathematic, econometric or artificial intelligence dev...

  9. The scoring of movements in sleep.

    Walters, Arthur S; Lavigne, Gilles; Hening, Wayne; Picchietti, Daniel L; Allen, Richard P; Chokroverty, Sudhansu; Kushida, Clete A; Bliwise, Donald L; Mahowald, Mark W; Schenck, Carlos H; Ancoli-Israel, Sonia

    2007-03-15

    The International Classification of Sleep Disorders (ICSD-2) has separated sleep-related movement disorders into simple, repetitive movement disorders (such as periodic limb movements in sleep [PLMS], sleep bruxism, and rhythmic movement disorder) and parasomnias (such as REM sleep behavior disorder and disorders of partial arousal, e.g., sleep walking, confusional arousals, night terrors). Many of the parasomnias are characterized by complex behaviors in sleep that appear purposeful, goal directed and voluntary but are outside the conscious awareness of the individual and therefore inappropriate. All of the sleep-related movement disorders described here have specific polysomnographic findings. For the purposes of developing and/or revising specifications and polysomnographic scoring rules, the AASM Scoring Manual Task Force on Movements in Sleep reviewed background literature and executed evidence grading of 81 relevant articles obtained by a literature search of published articles between 1966 and 2004. Subsequent evidence grading identified limited evidence for reliability and/or validity for polysomnographic scoring criteria for periodic limb movements in sleep, REM sleep behavior disorder, and sleep bruxism. Published scoring criteria for rhythmic movement disorder, excessive fragmentary myoclonus, and hypnagogic foot tremor/alternating leg muscle activation were empirical and based on descriptive studies. The literature review disclosed no published evidence defining clinical consequences of excessive fragmentary myoclonus or hypnagogic foot tremor/alternating leg muscle activation. Because of limited or absent evidence for reliability and/or validity, a standardized RAND/UCLA consensus process was employed for recommendation of specific rules for the scoring of sleep-associated movements. PMID:17557425

  10. Correlation of signal intensity ratio on orbital MRI-TIRM and clinical activity score as a possible predictor of therapy response in Graves' orbitopathy - a pilot study at 1.5 T

    This study seeks to describe the predictive value of the signal intensity ratio (SIR) in magnetic resonance imaging-turbo inversion recovery magnitude (MRI-TIRM) in patients with Graves' orbitopathy (GO) with regard to predictability of therapy response. Included in this prospective pilot study were 36 consecutive patients with GO and 25 control subjects. Patients were clinically assessed according to the European Group on Graves' Orbitopathy recommendations with active GO defined by a clinical activity score (CAS) ≥ 3. On magnetic resonance (MR) imaging, muscle inflammation was measured with a region of interest set within the brightest extra-ocular muscle both on coronal turbo inversion recovery magnitude (TIRM) and on fat suppressed gadolinium-enhanced T1-weighted sequences. To calculate the SIR, the measured signal intensity was set in proportion to that of the ipsilateral temporalis muscle. Signal intensity ratio in coronal T2-weighted TIRM sequences in either group ranged from 1.22 to 4.92 (mean 2.04) in patients with GO and from 1.18 to 2.4 (mean 1.63) in controls without GO. The observed differences were significant on the TIRM sequences (right eye p = 0.023; left eye p = 0.022), whereas, no significant differences could be detected on the T1-weighted sequences (right eye p = 0.396; left eye p = 0.498). A cut off value of SIR > 2.5 for a CAS ≥ 4 to discriminate active from inactive patients was statistically calculated. T2 relaxation time is a reliable tool in detecting active GO. The difference in T2-SIR versus T1-SIR is helpful to distinguish inflammatory oedema of the extra ocular muscles from intra-orbital congestion due to reduced venous outflow. (orig.)

  11. Correlation of signal intensity ratio on orbital MRI-TIRM and clinical activity score as a possible predictor of therapy response in Graves' orbitopathy - a pilot study at 1.5 T

    Kirsch, Eberhard C.; Kaim, Achim H. [Hirslanden Clinic Aarau, Neuroradiology and Cranio-Facial-Center Hirslanden, Aarau (Switzerland); Oliveira, Marion Gregorio de [University Eye Clinic Basel, Basel (Switzerland); Arx, Georg von [basedow.ch, Interdiscipinary Centre for Graves' Orbitopathy, Olten (Switzerland)

    2010-02-15

    This study seeks to describe the predictive value of the signal intensity ratio (SIR) in magnetic resonance imaging-turbo inversion recovery magnitude (MRI-TIRM) in patients with Graves' orbitopathy (GO) with regard to predictability of therapy response. Included in this prospective pilot study were 36 consecutive patients with GO and 25 control subjects. Patients were clinically assessed according to the European Group on Graves' Orbitopathy recommendations with active GO defined by a clinical activity score (CAS) {>=} 3. On magnetic resonance (MR) imaging, muscle inflammation was measured with a region of interest set within the brightest extra-ocular muscle both on coronal turbo inversion recovery magnitude (TIRM) and on fat suppressed gadolinium-enhanced T1-weighted sequences. To calculate the SIR, the measured signal intensity was set in proportion to that of the ipsilateral temporalis muscle. Signal intensity ratio in coronal T2-weighted TIRM sequences in either group ranged from 1.22 to 4.92 (mean 2.04) in patients with GO and from 1.18 to 2.4 (mean 1.63) in controls without GO. The observed differences were significant on the TIRM sequences (right eye p = 0.023; left eye p = 0.022), whereas, no significant differences could be detected on the T1-weighted sequences (right eye p = 0.396; left eye p = 0.498). A cut off value of SIR > 2.5 for a CAS {>=} 4 to discriminate active from inactive patients was statistically calculated. T2 relaxation time is a reliable tool in detecting active GO. The difference in T2-SIR versus T1-SIR is helpful to distinguish inflammatory oedema of the extra ocular muscles from intra-orbital congestion due to reduced venous outflow. (orig.)

  12. ACCUMULATION OF NITROGEN COMPOUNDS AND NITRATE REDUCTASE ACTIVITY IN LETTUCE CULTIVATED IN DIFFERENT CROP SYSTEMS ACÚMULO DE COMPOSTOS NITROGENADOS E ATIVIDADE DA REDUTASE DO NITRATO EM ALFACE PRODUZIDA EM DIFERENTES SISTEMAS DE CULTIVO

    Fernanda Nunes Ibrahim

    2008-09-01

    Full Text Available

    Nitrate content determination is important for food quality evaluation, therefore when ingested nitrate is reduced the nitrite, which can generate harmful compounds to the human organism. Ahead of this, the present work had as objective to study the transport and accumulation of nitrogen compounds and the nitrate reductase activity in lettuce cultivar 'Vera' produced in Registro (SP in different cropping systems. Were collected samples of the xylem sap, aerial part and root for quantification of nitrogen compounds and of the reductase activity <em>in vivoem>. The nitrate concentration in the xylem sap, the nitrate and amino acids contents, as well as the nitrate reductase activity, demonstrated more intense transport, accumulation and assimilation in plants cultivated in in hydroponic solution, followed of the conventional system and finally, of the organic. The stem of the plant in the three systems of culture presented high capacity of accumulation and assimilation the nitrogen compounds. The nitrate reductase activity in leaves was superior of the root. The content nitrate, independent of the culture system, varied of 24.32 the 800.06 mg kg-1 of FW in the different parts of the plant. However, it did not exceed the maximum

  13. Occurrence of Giardia cysts and Cryptosporidium oocysts in activated sludge samples in Campinas, SP, Brazil Ocorrência de cistos de Giardia e oocistos de Cryptosporidium em amostras de lodo ativado em Campinas, SP, Brasil

    Luciana Urbano Santos

    2004-04-01

    Full Text Available Giardia and Cryptosporidium have caused several outbreaks of gastroenteritis in humans associated with drinking water. Contaminated sewage effluents are recognized as a potential source of waterborne protozoa. Due to the lack of studies about the occurrence of these parasites in sewage samples in Brazil, we compared the efficiency of two procedures for concentrating cysts and oocysts in activated sludge samples of one sewage treatment plant. For this, the samples were submitted to i concentration by the ether clarification procedure (ECP and to ii purification by sucrose flotation method (SFM and aliquots of the pellets were examined by immunofluorescence. Giardia cysts were present in all samples (100.0%; n = 8 when using ECP and kit 1 reagents, while kit 2 resulted in six positive samples (85.7%; n = 7. As for SFM, cysts were detected in 75.0% and 100.0% of these samples (for kit 1 and 2, respectively. Regarding Cryptosporidium, two samples (25.0%; kit 1 and 28.5% for kit 2 were detected positive by using ECP, while for SFM, only one sample (examined by kit 1 was positive (12.5%. The results of the control trial revealed Giardia and Cryptosporidium recovery efficiency rates for ECP of 54.5% and 9.6%, while SFM was 10.5% and 3.2%, respectively. Considering the high concentration detected, a previous evaluation of the activated sludge before its application in agriculture is recommended and with some improvement, ECP would be an appropriate simple technique for protozoa detection in sewage samples.Giardia e Cryptosporidium causaram vários surtos epidêmicos de gastroenterite, associados à água potável. Efluentes de esgoto contaminados foram incriminados como uma fonte potencial de cistos e oocistos. Uma investigação foi conduzida para verificar a presença de cistos de Giardia e oocistos de Cryptosporidium em amostras de lodo ativado de uma Estação de Tratamento de Esgoto. Para isto as amostras foram submetidas: i a concentração pelo

  14. A Great Barrier Reef <em>Sinularia> sp. Yields Two New Cytotoxic Diterpenes

    Cherie A. Motti

    2012-07-01

    Full Text Available The methanol extract of a <em>Sinularia em>sp., collected from Bowden Reef, Queensland, Australia, yielded ten natural products. These included the new nitrogenous diterpene (4<em>R>*,5<em>R>*,9<em>S>*,10<em>R>*,11<em>Z>-4-methoxy-9-((dimethylamino-methyl-12,15-epoxy-11(13-en-decahydronaphthalen-16-ol (1, and the new lobane, (1<em>R*>,2<em>R*>,4<em>S*>,15<em>E>-loba-8,10,13(14,15(16-tetraen-17,18-diol-17-acetate (2. Also isolated were two known cembranes, sarcophytol-B and (1<em>E>,3<em>E>,7<em>E>-11,12-epoxycembratrien-15-ol, and six known lobanes, loba-8,10,13(15-triene-16,17,18-triol, 14,18-epoxyloba-8,10,13(15-trien-17-ol, lobatrientriol, lobatrienolide, 14,17-epoxyloba-8,10,13(15-trien-18-ol-18-acetate and (17<em>R>-loba-8,10,13(15-trien-17,18-diol. Structures of the new compounds were elucidated through interpretation of spectra obtained after extensive NMR and MS investigations and comparison with literature values. The tumour cell growth inhibition potential of 1 and 2 along with loba-8,10,13(15-triene-16,17,18-triol, 14,17-epoxyloba-8,10,13(15-trien-18-ol-18-acetate, lobatrienolide, (1<em>E>,3<em>E>,7<em>E>-11,12-epoxycembratrien-15-ol and sarcophytol-B were assessed against three human tumour cell lines (SF-268, MCF-7 and H460. The lobanes and cembranes tested demonstrated 50% growth inhibition in the range 6.8–18.5 µM, with no selectivity, whilst 1 was less active (GI50 70–175 µM.

  15. Atributos químicos e atividade microbiana em solos convertidos de savana para plantios de Acacia mangium Willd em Roraima. = Chemical attribuites and microbial activity in soils converted to savanna for plantations of Acacia mangium Willd. in Roraima, Brazil.

    Moisés Mourão Júnior

    2011-04-01

    Full Text Available A atividade microbiana tem sido empregada na avaliação de solos manejados, sendo um indicador importante na caracterização de solos alterados. Nesse sentido, objetivou-se com o presente trabalho avaliar o efeito de plantios de Acacia mangium com diferentes idades sobre os atributos químicos e atividade microbiana em solos representativos da Savana do Estado de Roraima. Os plantios de A. mangium de três e cinco anos encontravam-se em áreas de LATOSSOLO AMARELO Distrófico e os de quatro e seis anos em ARGISSOLO AMARELO Distrófico. As áreas próximas aos plantios com as mesmas condições de solos e com cobertura vegetal primária (savana natural constituiram as testemunhas. Foram amostrados os horizontes A e B sendo avaliados os atributos químicos dos solos e a atividade microbiana. A pobreza química e elevadasaturação por alumínio (%m dos solos estudados influenciaram significativamente nos menores valores de C-CO2 evoluído pela atividade microbiana. A maior atividade microbiana ocorreu em áreas plantadas independentemente do tipo de solo, em função das melhores condições químicas. Os maiores valores de C-CO2 evoluído correlacionaram-se melhor com os teores de carbono orgânico e matéria orgânica do solo. = Microbial activity has been used in the evaluation of soils, an important indicator in the characterization of alteredsoils. Therefore, this study has as aim to evaluate the effect of replacing natural vegetation to plantations of Acacia mangium onmicrobial activity in soils of savannas in Roraima state. The areas studied consisted of plantations of acacia with three and fiveyears in Yellow Latosol with four and six years in yellow Alfisols. Areas near the plantations with the same conditions of soiland vegetation (natural savanna were considered control. Were sampled the A and B horizons, corresponding depths 0-30 and 30-60 cm respectively, with three replications for a total of 36 experimental units. The results

  16. Herbicidas na nodulação e na atividade da nitrogenase em cultura de amendoim Influence of herbicides in nodulation and nitrogenase activities in peanuts crop

    Maria do Sarmo S. Soares Novo

    1990-01-01

    Full Text Available Com o objetivo de estudar os efeitos de trifluralin, metolachlor e linufon, aplicados, respectivamente, em pré-plantio-incorporado, pré-emergência e em pós-emergência, sobre o peso de matéria seca e número de nódulos e sobre a atividade da nitrogenase, foi conduzido um experimento de campo, em cultura de amendoim (Arachis hypogaea cv. Tatu plantada em rotação com cana-de-açúcar. Os resultados das avaliações feitas aos 30, 50 e 80 dias após a germinação mostraram não haver diferença entre tratamentos inoculados e não inoculados. Linuron foi o único herbicida prejudicial à nodulação, tendo afetado o número e o peso da matéria seca de nódulos, nas diferentes amostragens, e inibido a fixação do nitrogênio (estimada pela técnica da redução do acetileno. Não foi observado efeito prejudicial dos herbicidas metolachtor e trifluralin, na nodulação e na atividade da nitrogenase.A field investigation was carried out to determine the influence of herbicides on peanuts (Arachis hypogaea cv. Tatu Bradyrhizobium sp. symbiosis. The herbicides studied were trifluralin, metolachlor and linuron, applied, respectively, in pre-planted-incorporated, pre-emergence and post-emergence. The results evaluated 30, 50 and 80 days after germination, showed no difference between inoculated and non inoculated treatment. Linuron was the only herbicide that caused damage to nodulation, affecting the number and dry weight nodules and also inhibiting the nitrogen fixation (determined by nitrogenase activity. Metolachlor and trifluralin showed no damage effects on nodulation and in the nitrogenase activity.

  17. Avaliação da extensão da neoplasia em câncer da próstata: valor do PSA, da percentagem de fragmentos positivos e da escala de Gleason Extraprostatic disease prediction in patients with carcinoma of the prostate: role of PSA, prostatic biopsy fragments percentage and Gleason score

    Antonio Carlos Calvete

    2003-09-01

    Full Text Available OBJETIVOS: Avaliar o comportamento da percentagem de fragmentos da biópsia prostática, guiada por ultra-sonografia transretal, na previsão de doença extraprostática em pacientes com adenocarcinoma localizado de próstata e, também, comparar a eficiência deste parâmetro com aqueles obtidos pela avaliação do PSA sérico e escala de Gleason pré-operatórios. MÉTODOS: Foi realizado estudo retrospectivo não controlado de 522 pacientes portadores de adenocarcinoma localizado de próstata e submetidos a tratamento cirúrgico através da prostatectomia radical retropúbica. A idade dos pacientes variou entre 42 a 76 anos, média de 62,44 anos. Todos os pacientes foram submetidos à ultra-sonografia transretal com biópsia prostática (direta da lesão e/ou área suspeita e sextante antes da prostatectomia radical retropúbica. Os 522 pacientes foram divididos em grupos quanto à percentagem de fragmentos positivos encontrados na biópsia, que foram correlacionados com os achados anatomopatológicos de doença intraprostática (confinada à glândula e extraprostática (invasão tumoral da gordura periprostática e/ou invasão de colo vesical e/ou invasão das vesículas seminais e/ou linfonodos pélvicos positivos, do espécime cirúrgico. RESULTADOS: Na análise da percentagem de fragmentos positivos os grupos G1(0-25%, G2(26-50% e G3(51-75% apresentaram incidência de doença intraprostática duas a três vezes maior do que extraprostática. No entanto, quando mais de 75% dos fragmentos de biópsia foram positivos (G4 76-100%, a relação se inverteu, ocorrendo uma predominância de doença extraprostática sobre a doença intraprostática. Neste grupo 56,98% dos pacientes evidenciaram doença extraprostática. Houve diferença, estatisticamente, significativa da doença extraprostática entre os grupos G3 e G4 (p = 0,0068. CONCLUSÕES: Quando comparamos os três parâmetros para avaliar a ordem de eficiência em prever doença extraprost

  18. Evaluation of the antibacterial activity of Chilean plants traditionally used for wound healing therapy against multidrug-resistant <em>Staphylococcus aureusem>

    Holler, Jes Gitz; Søndergaard, Karen; Slotved, Hans-Christian;

    2012-01-01

    . Total phenolics and tannins were determined, and the antibacterial contribution of the latter was evaluated. The diffusion assay showed that 17 species were active against susceptible S. AUREUS and that 15 species were active against resistant S. AUREUS. Removal of tannins from extracts rendered only...

  19. Age-related and sex-specific differences in proteasome activity in individual <em>Drosophila> flies from wild type, longevity-selected and stress resistant strains

    Hansen, Tina Østergaard; Sarup, Pernille Merete; Loeschcke, Volker;

    2012-01-01

    that in C1 males. However, in longevity-selected LS1 flies the proteasome activity was significantly lower compared to C1 flies, but the sex differences were maintained to some extent. Five other stress resistant lines also had significantly reduced proteasome activity in both sexes. During ageing...

  20. Guidance for establishment and implementation of a national sample management program in support of EM environmental sampling and analysis activities

    The role of the National Sample Management Program (NSMP) proposed by the Department of Energy's Office of Environmental Management (EM) is to be a resource for EM programs and for local Field Sample Management Programs (FSMPs). It will be a source of information on sample analysis and data collection within the DOE complex. Therefore the NSMP's primary role is to coordinate and function as a central repository for information collected from the FSMPs. An additional role of the NSMP is to monitor trends in data collected from the FSMPs over time and across sites and laboratories. Tracking these trends will allow identification of potential problems in the sampling and analysis process

  1. A pesquisa em cognição e as atividades escolares de leitura Research on cognition and reading activities in school

    Ana Flávia Lopes Magela Gerhardt

    2010-06-01

    Full Text Available Este artigo reúne pressupostos teóricos da Linguística Cognitiva e da Psicolinguística, em especial os estudos em metacognição, a fim de discutir problemas relacionados à leitura nas aulas de língua materna e estrangeira, principalmente no que tange à validação das questões de interpretação de textos. Para tanto, analisamos questões presentes em materiais didáticos de língua materna e estrangeira, a fim de sugerir formas de trabalhar a interpretação de textos, a partir da visão de que a cognição humana opera em basicamente dois planos de percepção/conceptualização. Conscientes da necessidade de abordar em várias frentes o problema da má qualidade de leitura do aluno brasileiro, apresentamos nossa proposta como parte de um projeto de pesquisa maior, que inclui o que o aluno pode aprender acerca do funcionamento de sua própria mente, e como pode utilizá-la satisfatoriamente para realizar as atividades de leitura que lhe são solicitadas, na escola e fora dela.This paper assembles theoretical assumptions on Cognitive Linguistics and Psycholinguistics, especially those related to studies on Metacognition, in order to discuss problems on reading in native and foreign languages, mainly reading comprehension activities. We analyze activities of native and foreign language textbooks, in order to suggest interesting and relevant ways to work with reading comprehension, considering that human cognition basically operates in two levels of perception/conceptualization. Due to the need to address the problem of low quality of reading in Brazilian school in several ways, we present our proposal as a part of a greater research project, which includes how students can learn about their mind's work and how they can use it to accomplish reading activities in school and beyond.

  2. Ligand Identification Scoring Algorithm (LISA)

    Zheng, Zheng; Merz, Kenneth M.

    2011-01-01

    A central problem in de novo drug design is determining the binding affinity of a ligand with a receptor. A new scoring algorithm is presented that estimates the binding affinity of a protein-ligand complex given a three-dimensional structure. The method, LISA (Ligand Identification Scoring Algorithm), uses an empirical scoring function to describe the binding free energy. Interaction terms have been designed to account for van der Waals (VDW) contacts, hydrogen bonding, desolvation effects and metal chelation to model the dissociation equilibrium constants using a linear model. Atom types have been introduced to differentiate the parameters for VDW, H-bonding interactions and metal chelation between different atom pairs. A training set of 492 protein-ligand complexes was selected for the fitting process. Different test sets have been examined to evaluate its ability to predict experimentally measured binding affinities. By comparing with other well known scoring functions, the results show that LISA has advantages over many existing scoring functions in simulating protein-ligand binding affinity, especially metalloprotein-ligand binding affinity. Artificial Neural Network (ANN) was also used in order to demonstrate that the energy terms in LISA are well designed and do not require extra cross terms. PMID:21561101

  3. ANTIBACTERIAL ACTIVITY OF LENTINULA EDODES GROWN IN LIQUID MEDIUM Atividade antibacteriana de Lentinula edodes cultivado em meio líquido

    Noemia Kazue Ishikawa

    2001-10-01

    Full Text Available The antibacterial activity of 35 isolates of Lentinula edodes, a shiitake mushroom, against Bacillus subtilis was evaluated by diffusion technique in agar with a semi-solid overlay. All isolates inhibited B. subtilis and the isolate Le1 promoted the formation of the largest inhibition zone. L. edodes Le1 also presented antibacterial activity against foodborne pathogens and food contaminant bacteria, particularly Gram-positive species. The antibacterial activity of the culture filtrate after 18-25 days of cultivation of L. edodes in broth at 25ºC was high. The inhibitory activity was observed only in the organic layer when the culture filtrate was partitioned between ethyl acetate and water, suggesting that the inhibitory substances have low polarity. The silica gel thin-layer zone at Rf values of 0.63-0.80, developed in chloroform - acetone - ethyl acetate - methanol = 40:5:5:2, was responsible for the antibacterial activity against B. subtilis. The inhibitory activity of L. edodes was detectable in the culture filtrate after heat treatment at 100ºC for 10 min and after storage at 4ºC for 120 days.A atividade antibacteriana de 35 isolados de Lentinula edodes (shiitake contra Bacillus subtilis foi avaliada pela técnica de difusão em sobrecamada de ágar semi-sólido. Todos os isolados avaliados inibiram o crescimento de B. subtilis sendo o isolado Le1 o que apresentou maior halo de inibição. L. edodes Le1 também inibiu o crescimento de bactérias patogênicas e deterioradoras de alimentos, especialmente as Gram-positivas. Maior atividade antibacteriana do filtrado da cultura de L. edodes em meio líquido foi observada entre 18-25 dias de incubação, a 25ºC. O fracionamento do filtrado da cultura com acetato de etila e água permitiu evidenciar a atividade antagonista somente na fase orgânica, sugerindo que as substâncias inibitórias apresentam baixa poloridade. A cromatografia em camada fina, com o sistema de solventes clorof

  4. Low Apgar scores at 5 minutes in a low risk population: maternal and obstetrical factors and postnatal outcome Baixos índices de Apgar no quinto minuto de vida em população de baixo risco: fatores maternos e obstétricos e resultados pós-natais

    Eugenia Maria Assunção Salustiano

    2012-10-01

    Full Text Available OBJECTIVE: To evaluate the association between Apgar scores of less than seven at five minutes (AS5min 7 at 5 minutes who were randomly selected by a computer program. The main outcomes were neonatal death, newborn respiratory distress, need for orotracheal intubation and neonatal intensive care unit (NICU, and hypoxic-ischemic-encephalopathy. RESULTS: After multiple regression analysis, repeated late decelerations on cardiotocography (OR: 2.4; 95% CI: 1.4-4.1 and prolonged second stage of labor (OR: 3.3; 95% CI: 1.3-8.3 were associated with AS5min 0.05. CONCLUSION: Repeated late decelerations and prolonged second stage of labor in the low-risk population are predictors of AS5min OBJETIVO: Avaliar a associação entre índice de Apgar menor que sete no 5º minuto, os fatores pré-natais e resultados pós-natais. MÉTODOS: Trata-se de estudo retrospectivo com 27.252 recém-nascidos em maternidade escola com população de baixo risco obstétrico, de janeiro de 2003 a dezembro de 2010. Prontuários de todos os casos com índice de Apgar 7 no 5º minuto, escolhidos ao acaso, foram revisados. Os principais desfechos estudados foram: óbito neonatal, insuficiência respiratória neonatal, necessidade de intubação orotraqueal e de unidade terapia intensiva (UTI neonatal e encefalopatia hipóxico-isquêmica. RESULTADOS: Após análise de regressão múltipla, desacelerações tardias (DIP II (OR: 2,4; IC95%: 1,4-4,1 e período expulsivo prolongado (OR: 3,3; IC 95%: 1,3-8,3 se associaram com Apgar < 7 no 5º minuto; assim como com insuficiência respiratória ao nascimento (OR: 3,0; IC 95%: 1,3-6,9, intubação traqueal (OR: 2,5; IC 95%: 1,2-4,8, necessidade de UTI neonatal (OR: 9,5; IC 95%: 6,7-16,8 e encefalopatia hipóxico-isquêmica (OR: 14,1; IC 95%: 3,6-54,7. Nenhuma outra variável prénatal se associou com Apgar < 7 no 5º minuto (p < 0,05. CONCLUSÃO: DIP II e período expulsivo prolongado estão associados com Apgar < 7 no 5º minuto em

  5. Imobilização da pancreatina em carvão ativado e em alumina para o preparo de hidrolisados de soro de leite = Immobilization of pancreatin in activated carbon and in alumina for preparing whey hydrolysates

    Viviane Dias Medeiros Silva

    2005-07-01

    Full Text Available Tendo como objetivo a redução de custos do processo de fabricação dehidrolisados protéicos, estudou-se neste trabalho a imobilização da pancreatina, por adsorção, em carvão ativado e em alumina. Para isso, foram testadas diferentes condições de imobilização (30, 60 e 90min a 25°C, e 12h a 5°C. Para verificar a taxa de imobilização, determinou-se indiretamente a enzima não adsorvida nos suportes. Ao se utilizar o carvão ativado, não foi observada diferença significativa entre as condições testadas, tendo-se obtido 100% de imobilização enzimática. Para a alumina, a melhor condição foi a de 90min, na qual se obteve 37% de imobilização. A medida do grau de exposição da fenilalanina, pela espectrofotometria derivada segunda, foi empregada para a determinação da estabilidade operacional da enzima, tendo sido mostrado que a imobilização em carvão ativado e emalumina permitiu a reutilização da pancreatina por até 5 vezes e 2 vezes, respectivamente.Immobilization of pancreatin in activated carbon and in alumina was studied for producing protein hydrolysates, in order to reduce the process costs. Different immobilization conditions were tested (30, 60 and 90min at 25°C, and 12h at 5°C. For estimating the immobilization rate the amount of the non-adsorbed enzyme on the supports was indirectly determined. When activated carbon was used, no significant difference was observed among the tested conditions, obtaining 100% of enzymatic immobilization. In case of alumina, the best condition showed to be the 90min treatment which produced 37% of immobilization. The evaluation of the degree of exposition ofphenylalanine, by second derivative spectrophotometry, was used for the determination of the enzyme operational stability, and showed that the immobilization in activated carbon and in alumina allowed the reusability of the pancreatin for 5 times and 2 times,respectively.

  6. Interpreting Force Concept Inventory Scores: Normalized Gain and SAT Scores

    Coletta, Vincent P.; Phillips, Jeffrey A.; Steinert, Jeffrey J.

    2007-01-01

    Preinstruction SAT scores and normalized gains (G) on the force concept inventory (FCI) were examined for individual students in interactive engagement (IE) courses in introductory mechanics at one high school (N=335) and one university (N=292), and strong, positive correlations were found for both populations (r=0.57 and r=0.46, respectively).…

  7. A Bootstrap Procedure of Propensity Score Estimation

    Bai, Haiyan

    2013-01-01

    Propensity score estimation plays a fundamental role in propensity score matching for reducing group selection bias in observational data. To increase the accuracy of propensity score estimation, the author developed a bootstrap propensity score. The commonly used propensity score matching methods: nearest neighbor matching, caliper matching, and…

  8. Comparative Proteomic Analysis of <em>Lactobacillus> <em>plantarum> WCFS1 and Δ<em>ctsR> Mutant Strains Under Physiological and Heat Stress Conditions

    Daniela Fiocco

    2012-08-01

    Full Text Available Among Gram-positive bacteria, CtsR (Class Three Stress gene Repressor mainly regulates the expression of genes encoding the Clp ATPases and the ClpP protease. To gain a better understanding of the biological significance of the CtsR regulon in response to heat-shock conditions, we performed a global proteomic analysis of <em>Lactobacillus> <em>plantarum> WCFS1 and ∆<em>ctsR> mutant strains under optimal or heat stress temperatures. Total protein extracts from bacterial cells were analyzed by two-dimensional gel fractionation. By comparing maps from different culture conditions and different <em>L.> <em>plantarum> strains, image analysis revealed 23 spots with altered levels of expression. The proteomic analysis of <em>L.> <em>plantarum> WCFS1 and <em>ctsR> mutant strains confirms at the translational level the CtsR-mediated regulation of some members of the Clp family, as well as the heat induction of typical stress response genes. Heat activation of the putative CtsR regulon genes at transcriptional and translational levels, in the <em>∆ctsR> mutant, suggests additional regulative mechanisms, as is the case of <em>hsp1em>. Furthermore, isoforms of ClpE with different molecular mass were found, which might contribute to CtsR quality control. Our results could add new outlooks in order to determine the complex biological role of CtsR-mediated stress response in lactic acid bacteria.

  9. Skin scoring in systemic sclerosis

    Zachariae, Hugh; Bjerring, Peter; Halkier-Sørensen, Lars; Heickendorff, Lene; Søndergaard, Klaus

    1994-01-01

    Forty-one patients with systemic sclerosis were investigated with a new and simple skin score method measuring the degree of thickening and pliability in seven regions together with area involvement in each region. The highest values were, as expected, found in diffuse cutaneous systemic sclerosis...... (type III SS) and the lowest in limited cutaneous systemic sclerosis (type I SS) with no lesions extending above wrists and ancles. A positive correlation was found to the aminoterminal propeptide of type III procollagen, a serological marker for synthesis of type III collagen. The skin score is...

  10. Atividade do sistema antioxidante e desenvolvimento de aerênquima em raízes de milho 'Saracura' Antioxidant system activity and aerenchyma formation in 'Saracura' maize roots

    Fabricio José Pereira

    2010-05-01

    Full Text Available Este trabalho teve como objetivo avaliar a influência de sucessivos ciclos de seleção do milho 'Saracura' na atividade das enzimas do sistema antioxidante, e a relação dessas enzimas com a capacidade dessa variedade em desenvolver aerênquima. Sementes de 18 ciclos de seleção intercalados do milho 'Saracura' e da cultivar BR 107, sensível à hipoxia, foram semeadas em vasos e em casa de vegetação. As plantas foram submetidas ao alagamento intermitente de dois em dois dias. As amostras de raízes foram coletadas após 60 dias e analisaram-se as atividades das enzimas peroxidase do guaiacol, peroxidase do ascorbato e catalase, além da capacidade das plantas de cada ciclo desenvolverem aerênquima. Ao longo dos ciclos, as plantas apresentaram modificações na atividade das enzimas, com aumento na de peroxidase do ascorbato e diminuição na de catalase e de peroxidase do guaiacol. Observou-se, ainda, maior capacidade de desenvolver aerênquima nos últimos ciclos de seleção. A redução na atividade das enzimas do sistema antioxidante parece estar relacionada a um desbalanço na decomposição de H2O2.This work aimed to assess the influence of successive selection cycles in 'Saracura' maize on the enzyme activity of the antioxidant system and the relationship of these enzymes with the aerenchyma development capacity of this variety. Seeds of 18 intercalated selection cycles of the 'Saracura' maize and of the cultivar BR 107, sensitive to hipoxia, were sown in pots in the greenhouse. Plants were submitted to intermittent soil flooding each two days. After 60 days, the roots were sampled and analysis were done for the guaiacol peroxidase, ascorbate peroxidase, and catalase activities and for the capacity of the plants of each cycle to develop aerenchyma. The plants showed modifications in enzyme activity along the cycles, increasing the ascorbate peroxidase activity and decreasing the catalase and guaiacol peroxidase ones. A greater