WorldWideScience

Sample records for action review draft

  1. Pre-conference review of ICPD draft Programme of Action begins.

    1994-05-01

    The Preliminary Draft Document for the International Conference on Population and Development, scheduled for Cairo in September, 1994, aims to provide a shared vision of the needs and demands of population growth and development over the next 20 years, until 2015. Primary concerns focused on the link between population factors and sustainable development, and the need to empowers women and achieve greater gender equity and equality. A holistic approach was recommended in dealing with women's issues such as reproductive health. There are 30 subchapters pertaining to topics such as: poverty alleviation, environmental protection, family diversity, aging, sexuality, AIDS and other sexually transmitted diseases, adolescent health needs, gender relations, male responsibility, urbanization and education. Not only were actions outlined in the draft document, but the requirements of national, regional, and international efforts and resources were delineated. Almost all of the 162 participating countries were in agreement that population must be fully integrated into the development process. About 95% were in agreement on a reproductive health approach that widens considerably the purview of family planning. The approach was not on demographic targets, but on health and education needs of girls and women. Preparatory meetings strengthened chapters on population growth and structure, population development and education, partnerships with nongovernmental groups, child survival and health, and follow-up to the conference. The concerns were not as adequately addressed: unsafe abortion and the health needs of sexually active adolescents. Difficulties with terms such as "safe motherhood," "reproductive health," and "family planning," and several delegations' objections prevented stronger action. PMID:12179006

  2. A national program for energy-efficient mortgages and home energy rating systems: A blueprint for action. Review draft

    1992-03-01

    This Review Draft reports findings and recommendations of the National Collaborative on Home Energy Rating Systems and Mortgage Incentives for Energy Efficiency. The US Department of Energy, in cooperation with the US Department of Housing and Urban Development, formed this National Collaborative as a National Energy Strategy initiative. Participating in the Collaborative were representatives of the primary and secondary mortgage markets, builder and remodeler organizations, real estate and appraiser associations, the home energy rating system industry, utility associations, consumer and public interest groups, state and local government interest groups, and environmental organizations. The Collaborative`s purpose was to develop a voluntary national program encouraging energy efficiency in homes through mortgage incentives linked to home energy ratings.

  3. IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)

    On May 3, 2013, the Toxicological Review of Methanol (noncancer) (Revised External Review Draft) was posted for public review and comment. Subsequently, the draft Toxicological Review, Appendices, and draft IRIS Summary were reviewed internally by EPA and by other federal agenci...

  4. 77 FR 28883 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    2012-05-16

    ... HUMAN SERVICES Centers for Disease Control and Prevention Draft Public Health Action Plan--A National Public Health Action Plan for the Detection, Prevention, and Management of Infertility AGENCY: Centers... requesting public comment on the draft National Public Health Action Plan for the Detection, Prevention,...

  5. Energy market review releases draft report

    The Energy Market Review Releases draft report has made recommendations consistent with the Australian Gas Association (AGA)'s submissions in a number of areas. In particular, it has endorsed: 1. the need for an independent review of the gas access regime, to address the deficiencies with current access regulation identified by the Productivity Commission's Review of the National Access Regime; 2. the need for greater upstream gas market competition; 3. the principle that significant regulatory decisions should be subject to clear merits and judicial review; and 4. the need to avoid restrictions on retail energy prices. The report also endorses the need for a 'technology neutral' approach to greenhouse emissions abatement policy. It states that 'many of the current measures employed to reduce greenhouse gas emissions are poorly targeted', and that they 'target technologies or fuel types rather than greenhouse gas abatement.' Additionally, it explicitly recognises the key conclusions of the AGA's recently-released Research Paper, Reducing Greenhouse Emissions from Water Heating: Natural Gas as a Cost-effective Option. The draft report recommends the development of an economy-wide emissions trading system, to achieve a more cost-effective approach to greenhouse abatement

  6. 76 FR 11240 - Human Studies Review Board (HSRB); Notification of a Public Teleconference To Review a Draft...

    2011-03-01

    ... AGENCY Human Studies Review Board (HSRB); Notification of a Public Teleconference To Review a Draft Report From HSRB Meeting AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The U. S. Environmental Protection Agency (EPA) Office of the Science Advisor (OSA) announces a public teleconference...

  7. IRIS Toxicological Review of Halogenated Platinum Salts and Platinum Compounds (External Review Draft)

    EPA released the draft toxicological review for public comment under the Integrated Risk Information System (IRIS) Program. The original draft assessment (January 2009) has been archived but is available on this web page for the sake of transparency.

  8. 75 FR 16106 - Draft Toxicological Review of Dichloromethane: In Support of Summary Information on the...

    2010-03-31

    ... science-based human health assessments to support the Agency's regulatory activities. The IRIS database... AGENCY Draft Toxicological Review of Dichloromethane: In Support of Summary Information on the Integrated Risk Information System (IRIS) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of...

  9. 75 FR 26956 - Draft Toxicological Review of Hexachloroethane: In Support of the Summary Information in the...

    2010-05-13

    ... science-based human health assessments to support the Agency's regulatory activities. The IRIS database... AGENCY Draft Toxicological Review of Hexachloroethane: In Support of the Summary Information in the Integrated Risk Information System (IRIS) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...

  10. 77 FR 66626 - Deepwater Horizon Oil Spill; Draft Early Restoration Plan and Environmental Review

    2012-11-06

    ... Deepwater Horizon Oil Spill; Draft Early Restoration Plan and Environmental Review AGENCY: Interior. ACTION... Addressing Injuries Resulting from the Deepwater Horizon Oil Spill, the Federal and State natural resource... oil spill, which occurred on or about April 20, 2010, in the Gulf of Mexico. The purpose of...

  11. IRIS TOXICOLOGICAL REVIEW OF HEXAVALENT CHROMIUM (INTERAGENCY SCIENCE CONSULTATION DRAFT)

    On Septemeber 30, 2010, the draft Toxicological Review of Hexavalent Chromium and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agenc...

  12. 78 FR 65980 - Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation...

    2013-11-04

    ... AGENCY Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation... have produced draft Climate Change Adaptation Implementation Plans (``Implementation Plans'') that... health and the environment. As EPA articulated in its draft Agency Climate Change Adaptation Plan,...

  13. IRIS Toxicological Review of Urea (Interagency Science Discussion Draft)

    EPA is releasing the draft report, Toxicological Review of Urea,, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. C...

  14. 77 FR 40037 - Notice of the Peer Review Meeting for EPA's Draft Report Entitled An Assessment of Potential...

    2012-07-06

    ... AGENCY Notice of the Peer Review Meeting for EPA's Draft Report Entitled An Assessment of Potential...). ACTION: Notice of external peer review meeting. SUMMARY: The U.S. Environmental Protection Agency (EPA) is announcing that Versar, Inc., an EPA contractor for external peer review, has convened a panel...

  15. Review of Final Draft Core Standards

    R. James Milgram

    2013-04-01

    Full Text Available What follows are my comments on the nal draft of the CCSSI Core Mathematics Standards. There are a number of standards including, but not limited to 1-OA(6, 2-OA(2, 2-NBT(5, 3-OA(7, 3-NBT(2, 4-OA(4, 4-OA(6, 4-NF(1, 4-NF(2, 5-OA(3, 8-G(2, 8-G(4, F-LQE(5, G-SRT(4 that are completely unique to this document, andmost of them seem problematic to me. I have repeatedly asked for references justifying the insertions of these or similar standards in previous drafts, but references have not been provided. Consequently, to my knowledge, there is no real research base for including any of these standards in the document.

  16. Staff supplement to the draft report on human engineering guide to control room evaluation: response to comments, sample checklist, draft systems review guidelines, and evaluation procedures

    This staff supplement to Draft Report NUREG/CR-1580, Human Engineering Guide to Control Room Evaluation, provides staff responses to comments on the draft report and supplemental material not provided in the draft report. The supplemental material includes new draft guidelines for the systems review of nuclear power plant control rooms and sample checklists and corresponding human engineering guidelines

  17. 78 FR 38315 - Registration Review; Draft Human Health and Ecological Risk Assessments; Notice of Availability

    2013-06-26

    ... AGENCY Registration Review; Draft Human Health and Ecological Risk Assessments; Notice of Availability... availability of EPA's draft human health and ecological risk assessments for the registration review of... comprehensive draft risk assessments for each of the subject chemicals and is making them available for...

  18. 78 FR 17201 - Pesticide Chemicals; Registration Review; Draft Human Health and Ecological Risk Assessments...

    2013-03-20

    ... AGENCY Pesticide Chemicals; Registration Review; Draft Human Health and Ecological Risk Assessments... notice announces the availability of EPA's draft human health and ecological risk assessments for the... draft risk assessments for each of the subject chemicals and is making them available for public...

  19. Emergency action levels for light water reactors. Draft report

    United States nuclear power plants are currently preparing revised radiological emergency response plans. As part of these plans, each licensee is establishing plant-specific instrumentation readings, called emergency action levels (EALs), that indicate the presence of a problem and the need to declare one of four classes of emergency as designated by the U.S. Nuclear Regulatory Commission. In this report, the EALs prepared for a pressurized water reactor and a boiling water reactor are assessed to determine whether they meet the requirements of NUREG-0654, Rev. 1 Appendix 1. In addition, five recent nuclear incidents are studied to determine how their outcomes might have been affected by the new emergency response plans. Most of the EALs reviewed were judged adequate. In some cases, alternate EALs or sets of generic EALs are proposed to meet the intent of NUREG-0654 Rev 1 Appendix 1, and the wording of some of the initiating conditions for the four emergency classes is clarified. For three of the five incidents reviewed, the new emergency response plans probably would not have affected the outcome; in one case, the plans would probably have prevented core damage; and any effect on the outcome of the last incident is uncertain

  20. 75 FR 69064 - Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the...

    2010-11-10

    ... AGENCY Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the... period on September 30, 2010 (75 FR 60454) for the external review draft human health assessment titled, ``Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the Integrated...

  1. An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios (External Review Draft)

    EPA has released an external review draft entitled, An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios(External Review Draft). The public comment period and the external peer-review workshop are separate processes that provide opportunities ...

  2. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Second External Review Draft, 2008)

    EPA has announced that the Second External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise synthesis and evaluation...

  3. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft, 2007)

    EPA has announced that the First External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise synthesis and eva...

  4. Review of site recommendation process in Draft Environmental Assessments

    In December 1984, the US Department of Energy (DOE) published Draft Environmental Assessments (EAs) on nine potentially acceptable nuclear waste repository sites. Five sites in the states of Mississippi, Nevada, Texas, Utah, and Washington were proposed in the Draft EAs for nomination under the Nuclear Waste Policy Act as suitable for further detailed study (site characterization). The Nevada, Texas, and Washington sites were further proposed for recommendation to the President as preferred for site characterization. This paper reviews the process that DOE used in selecting the three sites proposed for site characterization. The process is consistent with DOE's implementation guidelines for selecting repository sites, and proceeds in three steps. First, the sites are ranked in order of preference for each of twenty technical guidelines based on information in the Draft EAs. The second step combines the individual guideline rankings into postclosure and preclosure guideline group rankings, and, finally, into an overall ranking. In the third step, the sensitivity of the choice of the three preferred sites is examined for a range of guideline weightings

  5. Balancing RIF & Affirmative Action: A Guidebook for Administrators. Draft.

    Ruzicka, Pat; Berard, Barbara, Ed.

    The result of two seminars bringing together educators to discuss the "often conflicting requirements of affirmative action and reductions in force" (RIF), this booklet is intended to provide practical insights and suggestions on meeting affirmative action goals "in situations characterized by staff and program cutbacks." Chapter 1 describes…

  6. 78 FR 56719 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    2013-09-13

    ...: Action Level'' that appeared in the Federal Register of July 15, 2013 (78 FR 42086). The draft guidance...-1639. SUPPLEMENTARY INFORMATION: I. Background In the Federal Register of July 15, 2013 (78 FR 42086... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Arsenic in Apple...

  7. Upstream petroleum industry flaring guide : review draft

    The Alberta requirements and expectations for upstream petroleum flaring are presented. Flaring is associated with a wide range of energy activities including oil and gas well drilling and well completion operations. The guide incorporates the recommendations made to the Alberta Energy and Utilities Board (EUB) in June 1998 by the multi-stakeholder Clean Air Strategic Alliance (CASA) on associated or solution gas flaring. Additional requirements which address flaring issues not covered in the CASA report are also included in this guide. The Guide requires a 15 per cent reduction in solution gas flare volume by the end of year 2000 from the 1996 baseline, and a 25 per cent reduction by the end of 2001. The Guide prescribes new flare performance requirements for all flares, within three years for existing solution gas flares, five years for flares at other existing permanent facilities. It sets personal consultation and public notification requirements for new and existing solution gas batteries, and new sulphur recovery requirements for facilities not covered by existing EUB regulations. The Guide also addresses the question of conflict resolution to deal with flaring concerns, the release of flaring and venting data, the proposed reduction of flare limits, progress towards minimizing requirements for electricity generators using otherwise flared gas, annual reporting to the EUB, and management framework review in 2001

  8. 75 FR 29534 - Inorganic Nitrates-Nitrite, Carbon and Carbon Dioxide, and Sulfur Registration Review; Draft...

    2010-05-26

    ... AGENCY Inorganic Nitrates-Nitrite, Carbon and Carbon Dioxide, and Sulfur Registration Review; Draft... draft ecological risk assessment for the registration review of inorganic nitrates - nitrites, carbon... occur for all inorganic nitrates- nitrites, carbon and carbon dioxide uses, as well as gas...

  9. 75 FR 60454 - Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the...

    2010-09-30

    ... AGENCY Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the..., ``Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the Integrated Risk..., 2010. The listening session on the draft assessment for hexavalent chromium will be held on November...

  10. 76 FR 20349 - Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the...

    2011-04-12

    ... AGENCY Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the..., ``Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the Integrated Risk... workshop on the draft assessment for Hexavalent Chromium will be held on May 12, 2011, beginning at 8:30...

  11. 78 FR 59685 - Registration Review; Draft Human Health and Ecological Risk Assessment; Notice of Availability

    2013-09-27

    ... AGENCY Registration Review; Draft Human Health and Ecological Risk Assessment; Notice of Availability... availability of EPA's draft human health and ecological risk assessments for the registration review for 2... providing advice on ecological risk assessment tools and scientific approaches in developing listed...

  12. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft, 2013)

    EPA is announcing the availability of the First External Review Draft of the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria for public comment and independent peer review. This draft document provides EPA’s evaluation and synthesis of the most polic...

  13. 75 FR 18205 - Notice of Peer Review Meeting for the External Peer Review Drafts of Two Documents on Using...

    2010-04-09

    ... the draft documents (74 FR 41695), and on September 17, 2009 extended the comment period to 60 days (74 FR 47794), thus closing the public comment period on October 16, 2009. The public comment period... AGENCY Notice of Peer Review Meeting for the External Peer Review Drafts of Two Documents on...

  14. Draft emergency action level guidelines for nuclear power plants

    This document is provided for interim use during the initial phases of the NRC effort to promptly improve emergency preparedness at operating nuclear power plants. Changes to the document can be expected as experience is gained in its use and public comments are received. Further, the Commission has initiated a rulemaking procedure, now scheduled for completion in January 1930 in the area of Emergency Planning and Preparedness. Additional requirements are to be expected when rulemaking is completed and some modifications to this document may be necessary. Four classes of Emergency Action Levels are established which replace the classes in Regulatory Guide 1.101, each with associated examples of initiating conditions. The classes are: - Notification of Unusual Event; - Alert; - Site Emergency; - General Emergency. The rationale for the notification and alert classes is to provide early and prompt notification of minor events which could lead to more serious consequences given operator error or equipment failure or which might be indicative of more serious conditions which are not yet fully realized. A gradation is provided to assure fuller response preparations for more serious indicators. The site emergency class reflects conditions where some significant releases are likely or are occurring but where a core melt situation is not indicated based on current information. In this situation full mobilization of emergency personnel in tie :near site environs is indicated as well as dispatch of monitoring teams and associated communications. The general emergency class involves actual or imminent substantial core degradation or malting with the potential for loss of containment. The immediate action for this class is sheltering (staying inside) rather thai evacuation until an assessment can be made that (1) an evacuation is indicated and (2) an evacuation, if indicated, can be completed prior to significant release and transport of radioactive material to the affected

  15. 75 FR 69078 - Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA)

    2010-11-10

    ... AGENCY Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA) AGENCY... a workshop to evaluate initial draft materials for the Pb Integrated Science Assessment (ISA) is... within each discipline to assist EPA in integrating within and across disciplines. This workshop...

  16. 75 FR 69065 - Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk...

    2010-11-10

    ... AGENCY Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk... the draft human health assessment titled, ``Toxicological Review of Urea: In Support of Summary... workshop on the draft assessment for Urea will be held via teleconference on December 13, 2010,...

  17. IRIS Toxicological Review of Hexavalent Chromium (2010 External Review Draft)

    [UPDATE] New Schedule for IRIS Hexavalent Chromium Assessment In Feb 2012, EPA developed a new schedule for completing the IRIS hexavalent chromium assessment. Based on the recommendations of the external peer review panel, which met in May 2011 to review the dra...

  18. Review of the draft supplement environmental impact statement

    The Draft Supplement Environmental Impact Statement (SEIS) for WIPP does not provide adequate justification to support the proposed action of shipping up to 620,000 cubic feet of transuranic (TRU) waste to WIPP before demonstrating compliance with the Environmental Protection Agency's (EPA) Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes. The ''alternative action'' of shipping no waste to WIPP prior to demonstrating compliance with the EPA Standards has been dismissed without sufficient discussion and justification. The document contains mistakes in calculations, reflects an erroneous knowledge of the history of the project, presents tables without units, and displays an indifference to the statistical precision of predictions. It also does not adequately address the environmental impacts of the potential failure to complete the demonstration of compliance with the EPA Standards by October 1993. By comparison, DOE plans to complete the demonstration of compliance with the same standards before starting construction of the high-level waste repository in Nevada. These two diametrically opposed approaches by DOE, for WIPP and for the Yucca Mountain repository, need to be addressed

  19. IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)

    EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of hydrogen cyanide and cyanide salts that will appear on the Integrated Risk Information System (IRIS) database.

  20. IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)

    EPA is seeking additional public comment and external peer review of the scientific basis supporting the human health hazard and dose-response assessment of methanol (noncancer). Teleconference Details: The public may participate in th...

  1. IRIS TOXICOLOGICAL REVIEW OF UREA (EXTERNAL REVIEW DRAFT)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Urea that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  2. IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft 2010)

    UPDATE EPA is currently revising its Integrated Risk Information System (IRIS) assessment of formaldehyde to address the 2011 NAS peer review recommendations. This assessment addresses both noncancer and cancer human health effects that are relevant to assessing ...

  3. IRIS Toxicological Review of Trichloroethylene (TCE) (External Review Draft)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroethylene (TCE) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  4. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Interagency Science Consultation Draft)

    On March 10, 2016, the public comment draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by othe...

  5. IRIS Toxicological Review of Methanol (External Review Draft, 2013)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  6. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (Interagency Science Discussion Draft)

    EPA is releasing the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessme...

  7. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  8. 76 FR 20347 - Release of Draft Integrated Review Plan for the National Ambient Air Quality Standards for Lead

    2011-04-12

    ... (75 FR 8934). The draft IRP is being made available for consultation with CASAC and for public comment... AGENCY Release of Draft Integrated Review Plan for the National Ambient Air Quality Standards for Lead... National Ambient Air Quality Standards for Lead (draft IRP). This document contains the plans for...

  9. 76 FR 21736 - Draft Toxicological Review of Methanol (Non-Cancer) in Support of Summary Information on the...

    2011-04-18

    ... AGENCY Draft Toxicological Review of Methanol (Non-Cancer) in Support of Summary Information on the... Review of Methanol (Non-Cancer): In Support of Summary Information on the Integrated Risk Information... released an external peer review draft IRIS Toxicological Review for methanol...

  10. 78 FR 12764 - Draft Office of Health Assessment and Translation Approach for Systematic Review and Evidence...

    2013-02-25

    ... for Systematic Review and Evidence Integration for Literature-Based Health Assessments--February 2013... comments on the Draft Office of Health Assessment and Translation (OHAT) Approach for Systematic Review and... out literature-based health assessments that incorporates systematic review methodology....

  11. 76 FR 4115 - Request for the Technical Review of the Draft Current Intelligence Bulletin (CIB): Derivation of...

    2011-01-24

    ... Current Intelligence Bulletin (CIB): Derivation of Immediately Dangerous to Life and Health (IDLH) Values... Disease Control and Prevention (CDC) is conducting a public review of the draft, Current...

  12. 76 FR 58311 - Draft License Renewal Interim Staff Guidance LR-ISG-2011-05; Ongoing Review of Operating Experience

    2011-09-20

    ... Guidance (LR-ISG), LR-ISG-2011-05, ``Ongoing Review of Operating Experience.'' This LR-ISG provides... draft LR-ISG-2011-05 to clarify guidance on how the ongoing review of operating experience should be... COMMISSION Draft License Renewal Interim Staff Guidance LR-ISG-2011-05; Ongoing Review of...

  13. 77 FR 51798 - First Draft Documents Related to the Review of the National Ambient Air Quality Standards for Ozone

    2012-08-27

    ... AGENCY First Draft Documents Related to the Review of the National Ambient Air Quality Standards for... of the Ozone National Ambient Air Quality Standards: First External Review Draft. The Agency is... titled, Policy Assessment for the Review of the Ozone National Ambient Air Quality Standards:...

  14. Integrated Science Assessment (ISA) for Oxides of Nitrogen and Sulfur Environmental Criteria (First External Review Draft, Dec 2007)

    EPA is announcing that the First External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen and Sulfur – Environmental Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise ...

  15. 76 FR 67439 - External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic...

    2011-11-01

    ... AGENCY External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic... guidance for a 60 day comment period (76 FR 44586-44587). The public comment period ended on September 26... attend this peer review meeting as observers. Time will be set aside at the meeting for observers to...

  16. NPP Krsko Periodic Safety Review action plan

    In the current, internationally accepted, safety philosophy Periodic Safety Reviews (PSRs) are comprehensive reviews aimed at the verification that an operating NPP remains safe when judged against current safety objectives and practices and that adequate arrangements are in place to maintain an acceptable level of safety. These reviews are complementary to the routine and special safety reviews. They are long time-scale reviews intended to deal with the cumulative effects of plant ageing, modifications, operating experience and technical developments, which are not so easily comprehended over the shorter time-scale routine of safety reviews. The review was completed in 2005 and the next period will see the implementation of the action plan including some plant upgrades. The action plan lists issues that should be implemented at NPP Krsko together with associated milestones. The milestones were assumed based on best estimate resource availability and their ends can be potentially floated. In some cases, multiple corrective measures may be postulated to provide resolution for a given safety issue. The Slovenian Nuclear Safety Administration by decree approved the first periodic safety review and the implementation plan of activities arising from it. The entire implementation plan must be carried out by 15 October 2010. Report on the second periodic safety review must be submitted by the NEK not later than 15 December 2013. (author)

  17. Technical review of US Department of Energy draft area recommendation report for the crystalline repository project

    Foth and Van Dyke and Associates Inc. was retained by the Stockbridge-Munsee Community to evaluate the DOE's screening process for selection of candidate areas in crystalline rock terranes, and critically review the geologic and environmental factors utilized by the DOE in selecting the NC-3 area as a potentially acceptable site (PAS). We have reviewed the DOE's Draft Area Recommendation Report (ARR) issued in January 1986, and prepared our comments. In addition, geologic and environmental data pertaining to the Stockbridge-Munsee community and vicinity that was not included in the Draft ARR is presented. 24 refs., 7 figs., 4 tabs

  18. Basins 4.0 Climate Assessment Tool (Cat): Supporting Documentation and User Manual (External Review Draft)

    EPA has released of the draft document solely for the purpose of pre-dissemination peer review under applicable Information Quality Guidelines (IQGs). This document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agenc...

  19. 75 FR 51838 - Public Review of Draft Coastal and Marine Ecological Classification Standard

    2010-08-23

    ... at its July 20, 2010 meeting. The FGDC invites all stakeholders in coastal and marine ecology and... Geological Survey Public Review of Draft Coastal and Marine Ecological Classification Standard AGENCY... Marine Ecological Classification Standard. SUMMARY: The Federal Geographic Data Committee (FGDC)...

  20. 78 FR 27374 - Workshop To Review Initial Draft Materials for the Nitrogen Oxides (NOX

    2013-05-10

    ...As part of the review of the air quality criteria for nitrogen oxides (NOX) and primary (health-based) National Ambient Air Quality Standards (NAAQS) for nitrogen dioxide (NO2), EPA is announcing a workshop to evaluate preliminary draft materials that will inform the development of the NOX Integrated Science Assessment (ISA) for health effects. The workshop is......

  1. 75 FR 59716 - Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk...

    2010-09-28

    ... AGENCY Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk... Urea: In Support of Summary Information on the Integrated Risk Information System (IRIS)'' [EPA/ 635/R..., 2010. The listening session on the draft assessment for urea will be held on November 16,...

  2. Review of the draft supplement to the WIPP environmental impact statement DOE/EIS-0026-S-2

    New Mexico Environmental Evaluation Group's (EEG) review of the WIPP Disposal Phase Draft Supplemental Environmental Impact Statement (SEIS-II) concentrated on the radiological aspects of the Proposed Action, including transportation. The alternatives were reviewed in less detail. Some calculations were checked, mostly for the Proposed Action. Because of time constraints, there was little review of Hazardous Chemicals, Economics, or other Environmental Assessments. SEIS-II was written as a pre-decision document with the Alternatives all plausible and eligible to be selected. Also, the inventory of TRU waste for disposal went well beyond that portion of TRU waste that has been historically considered to be the WIPP inventory. This broadened scope is probably appropriate for an EIS but it is confusing to the reviewer who is aware of the statutory limits of wastes that are allowed to come to WIPP at the present time. EEG has attempted to keep the broadened scope of SEIS-II in mind during their review. The more important issues discussed within are: alternatives; related documents; transportation; questionable assumptions; use of the 75th percentile values; family farm scenario and inhalation doses; modification of BRAGFLO volumes; emplacement of remotely handled TRU wastes; conversion error; and remotely handled TRU casks

  3. IRIS Toxicological Review of Urea (Interagency Science Consultation Draft)

    On September 28, 2010, the Toxicological Review of Urea and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Of...

  4. 75 FR 47856 - Draft Emergency Action Level Frequently Asked Questions; Request for Comment

    2010-08-09

    ... available electronically at the NRC's Electronic Reading Room at http://www.nrc.gov/reading-rm/adams.html... Asked Questions is ML102030343. The draft question is also available on the NRC Web site at...

  5. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 6: Controls and guidance

    1991-01-01

    Viewgraphs of briefings from the Space Systems and Technology Advisory Committee (SSTAC)/ARTS review of the draft Integrated Technology Plan (ITP) on controls and guidance are included. Topics covered include: strategic avionics technology planning and bridging programs; avionics technology plan; vehicle health management; spacecraft guidance research; autonomous rendezvous and docking; autonomous landing; computational control; fiberoptic rotation sensors; precision instrument and telescope pointing; microsensors and microinstruments; micro guidance and control initiative; and earth-orbiting platforms controls-structures interaction.

  6. Four Draft Working Papers: PEER REVIEW IN ACADEMIC PROMOTION AND PUBLISHING: Its Meaning, Locus, and Future

    Harley, Diane

    2010-01-01

    As part of its Andrew W. Mellon Foundation-funded Future of Scholarly Communication Project, the Center for Studies in Higher Education (CSHE) has hosted two meetings to explore how peer review relates to scholarly communication and academic values. In preparation for an April 2010 workshop, four working papers were developed and circulated. They are presented as drafts here. (The proceedings from the April 2010 meeting will be published at a future date.) The topics covered include assessing...

  7. Drinking-water-criteria document for radium (draft). Scientific review

    This document reviews the following topics on radium; Physical and chemical properties; Toxicokinetics and human exposure; Health effects; Mechanisms of toxicity; and Quantification of toxicological effects

  8. HERBAL REMEDIES FOR GASTROPROTECTIVE ACTION: A REVIEW

    Ramesh Patel

    2012-05-01

    Full Text Available Herbal medicines have great importance in maintaining the health of every person. Demands of Herbal medicines are increasing in both developed and developing countries due to growing recognition of natural plants being lesser no. of side effect, easily available in surrounding place with low coast. Different parts of the plant have different active substances and these active substances may vary in their extent of activity and concentration. Most of active principles are present in leaves, flower, fruit, bark, root & seeds of the plant. Gastric diseases are a major and worldwide very common problem in every age of person. Its 90% arises commonly due to mostly used of non-steroidal anti-inflammatory category of drug and about 8 to 10% by used of most spicy and fast food(Junk Food. In this review we have described some medicinal plants with respect to their Gastroprotective action.

  9. Development of a draft of human factors safety review procedures for the Korean next generation reactor

    Lee, Jung Woon; Moon, B. S.; Park, J. C.; Lee, Y. H.; Oh, I. S.; Lee, H. C. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-02-01

    In this study, a draft of human factors engineering (HFE) safety review procedures (SRP) was developed for the safety review of KNGR based on HFE Safety and Regulatory Requirements and Guidelines (SRRG). This draft includes acceptance criteria, review procedure, and evaluation findings for the areas of review including HFE Program Management, Human Factors Analyses, Human Factors Design, and HFE Verification and Validation, based on Section 15.1 'Human Factors Engineering Design Process' and 15.2 'Control Room Human Factors Engineering' of KNGR Specific Safety Requirements and Chapter 15 'Human Factors Engineering' of KNGR Safety Regulatory Guides. For the effective review, human factors concerns or issues related to advanced HSI design that have been reported so far should be extensively examined. In this study, a total of 384 human factors issues related to the advanced HSI design were collected through our review of a total of 145 documents. A summary of each issue was described and the issues were identified by specific features of HSI design. These results were implemented into a database system. 8 refs., 2 figs. (Author)

  10. Development of a draft of human factors safety review procedures for the Korean Next Generation Reactor

    In this study, a draft of Human Factors Engineering (HFE) Safety Review Procedures (SRP) was developed for the safety review of KNGR based on HFE Safety and Regulatory Requirements and Guidelines (SRRG). This draft includes acceptance criteria, review procedure, and evaluation findings for the areas of review including HFE program management, human factors analyses, human factors design, and HFE verification and validation, based on section 15.1 'human factors engineering design process' and 15.2 'control room human factors engineering' of KNGR specific safety requirements and chapter 15 'human factors engineering' of KNGR safety regulatory guides. For the effective review, human factors concerns or issues related to advanced HSI design that have been reported so far should be extensively examined. In this study, a total of 384 human factors issues related to the advanced HSI design were collected through our review of a total of 145 documents. A summary of each issue was described and the issues were identified by specific features of HSI design. These results were implemented into a database system

  11. 76 FR 52995 - Draft License Renewal Interim Staff Guidance LR-ISG-2011-05: Ongoing Review of Operating...

    2011-08-24

    ... Interim Staff Guidance (LR-ISG), LR-ISG-2011-05, ``Ongoing Review of Operating Experience.'' This LR-ISG... draft LR-ISG-2011-05 to clarify guidance on how the ongoing review of operating experience should be... applicants should obligate themselves to the ongoing review of operating experience for license renewal....

  12. 75 FR 10252 - Release of Draft Documents Related to the Review of the National Ambient Air Quality Standards...

    2010-03-05

    ... Exposure Assessment to Support the Review of the Carbon Monoxide Primary National Ambient Air Quality... draft assessment document: Policy Assessment for the Review of the Carbon Monoxide National Ambient Air... Risk and Exposure Assessment to Support the Review of the Carbon Monoxide Primary National Ambient......

  13. 77 FR 56202 - Notification of an External Peer Review Meeting for the Draft Framework for Human Health Risk...

    2012-09-12

    ... AGENCY Notification of an External Peer Review Meeting for the Draft Framework for Human Health Risk... external peer review meeting. SUMMARY: The EPA Office of the Science Advisor announces that Versar, Inc., a... attend this peer review meeting as an observer. Time will be set aside for observers to give brief...

  14. Drinking-water criteria document for radon (draft). Scientific review

    The Office of Drinking Water (ODW), U.S. Environmental Protection Agency has prepared a Drinking Water Criteria Document on Radon. The document is an extensive review of radon on the following topics: Physical and chemical properties; Toxicokinetics and human exposure; Health effects of radon; Mechanisms of toxicity of radon; Quantification of toxicological effects

  15. Human-factors engineering-control-room design review: Shoreham Nuclear Power Station. Draft audit report

    A human factors engineering preliminary design review of the Shoreham control room was performed at the site on March 30 through April 3, 1981. This design review was carried out by a team from the Human Factors Engineering Branch, Division of Human Factors Safety. This report was prepared on the basis of the HFEB's review of the applicant's Preliminary Design Assessment and the human factors engineering design review/audit performed at the site. The presented sections are numbered to conform to the guidelines of the draft version of NUREG-0700. They summarize the teams's observations of the control room design and layout, and of the control room operators' interface with the control room environment

  16. 76 FR 55384 - External Peer Review Meeting for the Draft Guidance of Applying Quantitative Data To Develop Data...

    2011-09-07

    ... AGENCY External Peer Review Meeting for the Draft Guidance of Applying Quantitative Data To Develop Data... period (76 FR 33752-33753), which was subsequently extended to 60 days (76 FR 43999). The public comment... register to attend this peer review meeting as observers. Time will be set aside for observers to...

  17. 77 FR 38296 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    2012-06-27

    ... Detection, Prevention, and Management of Infertility (77 FR 28883). Written and electronic comments were to... male and female infertility, the plan outlines and summarizes actions needed to promote, preserve, and... Public Health Action Plan for the Detection, Prevention, and Management of Infertility AGENCY:...

  18. The process of consensus on EMF: SAB review of the EPA draft document on EMF and cancer

    Wilson, B. W.

    1992-06-01

    The EPA Draft Document on EMF and Cancers grew out of an earlier effort by EPA to track biological effects literature relative to radio-frequency (RF) exposure. Scope of the document was broadened to include extremely low frequency electric and magnetic fields prior to an announcement in 1986 that EPA would formally review the whole area of non-ionizing radiation. An extensive survey of the relevant bioeffects and epidemiologic literature was carried out, and writing on the document began in earnest on the document sometime in 1989. In its draft form, the document reviewed the literature on mechanisms of Interaction between electromagnetic fields and biological tissue, EMF epidemiologic studies, supporting evidence for carcinogenicity and research needs. In the early summer of 1990, a draft of the document was reviewed by some 22 individuals within the EPA and other government agencies. It was also sent out for external review to an additional 9 qualified scientists who had worked in the area and were familiar with EMF-related literature in epidemiology, biology, and physics. Many of the comments sent to EPA from this first review, prior to release of the draft for public comment, were strikingly similar to those resulting from the second (public) review process. Thus, it appears that much of the controversy that was later associated with the document could have been avoided had the authors been diligent in following the recommendations of the initial set of reviewers.

  19. 75 FR 47346 - Draft Strategic Plan for FY 2010-2015

    2010-08-05

    ..., 2010. Martin R. Melone, Director, Strategic Planning and Performance Management, United States... Draft Strategic Plan for FY 2010-2015 AGENCY: United States Department of the Treasury. ACTION: Notice... draft strategic plan for fiscal years 2010-2015 is available for public review and comment....

  20. 77 FR 2292 - Request for Nominations for Peer Reviewers for the Draft Research Report Entitled, “Investigation...

    2012-01-17

    ... December 14, 2011 (see Federal Register Vol. 76, No. 240 at http://www.gpo.gov/fdsys/pkg/FR-2011-12-14/pdf/FR-2011-12-14.pdf ). This draft report is not final as described in EPA's Information Quality... their current email address or other contact information. ADDRESSES: Peer reviewer...

  1. 75 FR 71702 - Science Advisory Board Staff Office; Request for Nominations of Experts for Review of EPA's Draft...

    2010-11-24

    ... gathered by the SAB Staff Office. Selection criteria to be used for Panel membership include: (a... AGENCY Science Advisory Board Staff Office; Request for Nominations of Experts for Review of EPA's Draft... Board (SAB) Staff Office is requesting public nominations for technical experts to augment the...

  2. 78 FR 9387 - Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation Plan

    2013-02-08

    ... AGENCY Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation Plan... Agency Climate Change Adaptation Plans in response to the President's October 2009 Executive Order (E.O... of EPA's Climate Change Adaptation Plan has been posted to a public docket and is available on...

  3. Building Capacity through Action Research Curricula Reviews

    Lee, Vanessa; Coombe, Leanne; Robinson, Priscilla

    2015-01-01

    In Australia, graduates of Master of Public Health (MPH) programmes are expected to achieve a set of core competencies, including a subset that is specifically related to Indigenous health. This paper reports on the methods utilised in a project which was designed using action research to strengthen Indigenous public health curricula within MPH…

  4. A scoping review of definitions and frameworks of intersectoral action

    Alejandra Dubois; Louise St-Pierre; Mirella Veras

    2015-01-01

    AbstractIntersectoral action is rooted in all health promotion activities because the determinants of health lie outside of the health sector. Despite the increasing use of these terms (intersectoral action, intersectoral action for health, intersectoral collaboration), often interchangeably, we noted a lack of consensus on their definitions and conceptualizations. The objective of this paper is to report the results of a scoping review of the use of definitions for a set of related terms as ...

  5. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  6. An early review of the performance assessment in the draft compliance certification application for the Waste Isolation Pilot Plant

    On March 31, 1995, the US Department of Energy filed a draft application for certification of compliance with the US Environmental Protection Agency (USEPA) to show the Waste Isolation Pilot Plant's compliance with the USEPA's environmental standards, making the application the first of its kind. Demonstration of compliance is by performance assessment. This paper is an early review of the performance assessment in the draft application, by the Environmental Evaluation Group, an oversight group. The performance assessment in the draft application is incomplete. Not all relevant scenarios have been analyzed. The calculation of potential consequences often does not use experimental data but rather estimates by workers developing additional data. The final compliance application, scheduled for October 1996 needs to consider additional scenarios, and be fully based on experimental data

  7. Epoxide compositions, solidifying under radiation action (Review)

    A review on radiation hardening of epoxy oligomers is presented. The coatings on their basis possess a complex of high physicomechanical properties. It is shown that the investigations on radiation hardening of epoxy oligomers are carried out in two directions: preparation of unsaturated epoxyester acrylates and application of epoxy resin mixtures with traditional hardeners

  8. [Review comments on the Draft DOE Area Recommendation Report for the Crystalline Repository Project]: Final technical report

    Research performed under the grant primarily involved review and comment on the Draft Area Recommendations Report (DARR). However, because data and ''recommendations'' included in the DARR are unquestionably tied to years of research and dozens of technical reports and documents, i.e., Screening Methodologies, Regional characterization Reports, etc., it is essential that consultants to the Menominee Tribe review all the relevant DOE documents, working papers, etc. Given the short period provided for technical comment and limited funds available to the Tribe, a well designed and thorough technical review was (and is) without question impossible. What review and comment that did occur on a geotechnical level is included in this report

  9. Review of remedial actions applied at shallow land burial facilities

    Evaluation Research Corporation's Oak Ridge Operations office recently completed a review of remedial actions taken to correct problems at shallow land burial (SLB) facilities operating in the US. Two staff members from Evaluation Research Corporation's Oak Ridge Operations office recently visited eleven shallow land burial facilities to observe routine operations and remedial action activities. At each of these facilities, selected problems and remedial actions were identified and documented. The main problem areas for which remedial actions are taken include water management, subsidence, wind erosion, and biological intrusion. In addition, other site management considerations are discussed in the document prepared for the DOE-Low Level Waste Management Program. These include waste packaging, space utilization, physicochemical reactions facilitating migration of radionuclides, gas phase migration, trade-offs, improved practices, and future remedial actions. The review of remedial actions taken at SLB facilities revealed that the application and evaluation of remedial actions at operating SLB facilities are not well documented. This lack of documentation may be due to two factors. First, operations personnel are primarily involved with the implementation and modification of operating procedures, whereas research-related efforts to identify problems are more likely to find their way into the literature. Second, the recent concerns with problems at SLB facilities may have resulted in recent application of remedial actions

  10. Draft programmatic environmental impact statement for the Uranium Mill Tailings Remedial Action Ground Water Project

    The US Department of Energy (DOE) is responsible for performing remedial action to bring surface and ground water contaminant levels at 24 inactive uranium processing sites into compliance with the US Environmental Protection Agency (EPA) standards. DOE is accomplishing this through the Uranium Mill Tailings Remedial Action (UMTRA) Surface and Ground Water Projects. Remedial action will be conducted with the concurrence of the US Nuclear Regulatory Commission (NRC) and the full participation of affected states and Indian tribes. Uranium processing activities at most of 24 the inactive mill sites resulted in the contamination of ground water beneath and, in some cases, downgradient of the sites. This contaminated ground water often has elevated levels of constituents such as uranium and nitrate. The purpose of the UMTRA Ground Water Project is to eliminate, or reduce to acceptable levels, the potential health and the environmental consequences of milling activities by meeting the EPA standards in areas where ground water has been contaminated. The first step in the UMTRA Ground Water Project is the preparation of this programmatic environmental impact statement (PEIS). This document analyzes potential impacts of four programmatic alternatives, including the proposed action. The alternatives do not address site-specific ground water compliance strategies. Rather, the PEIS is a planning document that provides a framework for conducting the Ground Water Project; assesses the potential programmatic impacts of conducting the Ground Water Project; provides a method for determining the site-specific ground water compliance strategies; and provides data and information that can be used to prepare site-specific environmental impacts analyses more efficiently

  11. Draft Hanford Remedial Action Environmental Impact Statement and Comprehensive Land Use Plan: Summary

    This document analyzes the potential environmental impacts associated with establishing future land-use objectives for the US Department of Energy's Hanford Site. Impact analysis is performed by examining the consequences (primarily from remediation activities) of the actions determined necessary to achieve a desired future land-use objective. It should be noted that site-specific decisions regarding remediation technologies and remediation activities would not be made by this document, but rather by processes specified in the Comprehensive Environmental Response, Compensation and Liability Act of 1980 and the Resource Conservation and Recovery Act of 1976. To facilitate the establishment of future land-use objectives, the Hanford Site was divided into four geographic areas: (1) Columbia River; (2) reactors on the river; (3) central plateau; (4) all other areas. The future land-use alternatives considered in detail for each of the geographic areas are as follows: Columbia River--unrestricted and restricted; reactors on the river--unrestricted and restricted; central plateau--exclusive; all other areas--restricted. A No-Action Alternative also is included to provide a baseline against which the potential impacts of the proposed action can be assessed

  12. Draft Hanford Remedial Action Environmental Impact Statement and Comprehensive Land Use Plan: Volume 1 of 4

    This document analyzes the potential environmental impacts associated with establishing future land-use objectives for the US Department of Energy's Hanford Site. Impact analysis is performed by examining the consequences (primarily from remediation activities) of the actions determined necessary to achieve a desired future land-use objective. It should be noted that site-specific decisions regarding remediation technologies and remediation activities would not be made by this document, but rather by processes specified in the Comprehensive Environmental Response, Compensation and Liability Act of 1980 and the Resource Conservation and Recovery Act of 1976. To facilitate the establishment of future land-use objectives, the Hanford Site was divided into four geographic areas: (1) Columbia River; (2) reactors on the river; (3) central plateau; (4) all other areas. The future land-use alternatives considered in detail for each of the geographic areas are as follows: Columbia River--unrestricted and restricted; reactors on the river--unrestricted and restricted; central plateau--exclusive; all other areas--restricted. A No-Action Alternative also is included to provide a baseline against which the potential impacts of the proposed action can be assessed

  13. A review of action estimation methods for galactic dynamics

    Sanders, Jason L

    2015-01-01

    We review the available methods for estimating actions, angles and frequencies of orbits in both axisymmetric and triaxial potentials. The methods are separated into two classes. Unless an orbit has been trapped by a resonance, convergent, or iterative, methods are able to recover the actions to arbitrarily high accuracy given sufficient computing time. Faster non-convergent methods rely on the potential being sufficiently close to a separable potential and the accuracy of the action estimate cannot be improved through further computation. We critically compare the accuracy of the methods and the required computation time for a range of orbits in an axisymmetric multi-component Galactic potential. We introduce a new method for estimating actions that builds on the adiabatic approximation of Sch\\"onich & Binney (2012) and discuss the accuracy required for the actions, angles and frequencies using suitable distribution functions for the thin and thick discs, the stellar halo and a star stream. We conclude t...

  14. Revised draft Hanford remedial action environmental impact statement and comprehensive land-use plan: Executive summary

    This report evaluates the potential environmental impacts associated with implementing a comprehensive land-use plan for the Hanford Site for at least the next 50 years. With the exception of the required No-Action Alternative, each of the six alternatives presented represents a Tribal, Federal, state, or local agency's Preferred Alternative. Each alternative is presented separately. The DOE's Preferred Alternative anticipates multiple uses of the Hanford Site, including: consolidating waste management operations in the Central Plateau, allowing industrial development in the eastern and southern portions of the site, increasing recreational access to the Columbia River, and expanding the Saddle Mountain National Wildlife Refuge to include all of the Wahluke Slope (managed by the US Fish and Wildlife Service). The Hanford Site occupies 1,517 square kilometers (km2) (586 square miles [mi2]) in southeastern Washington. Today, the Hanford Site has diverse missions associated with environmental restoration, waste management, and science and technology. These missions have resulted in the growing need for a comprehensive, long-term approach to planning and development for the Site

  15. Revised draft Hanford remedial action environmental impact statement and comprehensive land-use plan

    This report evaluates the potential environmental impacts associated with implementing a comprehensive land-use plan for the Hanford Site for at least the next 50 years. With the exception of the required No-Action Alternative, each of the six alternatives presented represents a Tribal, Federal, state, or local agency's Preferred Alternative. Each alternative is presented separately. The DOE's Preferred Alternative anticipates multiple uses of the Hanford Site, including: consolidating waste management operations in the Central Plateau, allowing industrial development in the eastern and southern portions of the site, increasing recreational access to the Columbia River, and expanding the Saddle Mountain National Wildlife Refuge to include all of the Wahluke Slope (managed by the US Fish and Wildlife Service). The Hanford Site occupies 1,517 square kilometers (km2) (586 square miles [mi2]) in southeastern Washington. Today, the Hanford Site has diverse missions associated with environmental restoration, waste management, and science and technology. These missions have resulted in the growing need for a comprehensive, long-term approach to planning and development for the Site

  16. Canadian support for population stabilization. The Rome draft Plan of Action. Dr. Jean Augustine, MP (Canada).

    1996-01-01

    Canada strongly believes in the central role to be played by the civil sector in the process leading to the World Food Summit. Dr. Augustine, Member of Parliament of Canada, described how the Canadian Government involved 350 national organizations over an eight-month period in the creation of the country's official position on food security. Canada has also negotiated with several other countries and international organizations on issues such as trade, human rights, the right to food, and follow-up to the Plan of Action. Dr. Augustine summarized Canada's 18 priorities for the World Food Summit. The priorities include human rights and good governance; poverty reduction; peace, security and conflict resolution; national responsibility for food security; national and global partnerships; nutrition and health; human resource development; gender equity; population stabilization; trade liberalization; agricultural adjustment to international markets; post-harvest marketing and food marketing; the role of the private sector; capacity building; environment and sustainable production; and research and technology transfer. PMID:12292041

  17. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (External Review Draft)

    EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene glycol monobutyl ether that will appear on the Integrated Risk Information System (IRIS) database.

  18. 76 FR 38166 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    2011-06-29

    ...-HQ-OPP-2011-0482 Eric Miederhoff, (703) 347-8028, miederhoff.eric@epa.gov . Bacillus cereus, 6053... AGENCY Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions... review dockets for the pesticides listed in the table in Unit III.A. With this document, EPA is...

  19. IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  20. A review of action estimation methods for galactic dynamics

    Sanders, Jason L.; Binney, James

    2016-04-01

    We review the available methods for estimating actions, angles and frequencies of orbits in both axisymmetric and triaxial potentials. The methods are separated into two classes. Unless an orbit has been trapped by a resonance, convergent, or iterative, methods are able to recover the actions to arbitrarily high accuracy given sufficient computing time. Faster non-convergent methods rely on the potential being sufficiently close to a separable potential, and the accuracy of the action estimate cannot be improved through further computation. We critically compare the accuracy of the methods and the required computation time for a range of orbits in an axisymmetric multicomponent Galactic potential. We introduce a new method for estimating actions that builds on the adiabatic approximation of Schönrich & Binney and discuss the accuracy required for the actions, angles and frequencies using suitable distribution functions for the thin and thick discs, the stellar halo and a star stream. We conclude that for studies of the disc and smooth halo component of the Milky Way, the most suitable compromise between speed and accuracy is the Stäckel Fudge, whilst when studying streams the non-convergent methods do not offer sufficient accuracy and the most suitable method is computing the actions from an orbit integration via a generating function. All the software used in this study can be downloaded from https://github.com/jls713/tact.

  1. Connectivity of Streams and Wetlands to Downstream Waters: A Review and Synthesis of the Scientific Evidence (External Review Draft)

    The Environmental Protection Agency – through the independent Scientific Advisory Board (SAB) - is soliciting public comment on a new draft science report titled: Connectivity of Streams and Wetlands to Downstream Waters. A public docket has been opened to receive com...

  2. [Action modes of chlorine dioxide--a review].

    Wei, Mingken; Lai, Jieling; Zhan, Ping

    2012-04-01

    Chlorine dioxide (ClO2) is a highly effective disinfectant for food and potable water treatment. Till now, the action mode of ClO2 is still unclear. ClO2, can denature proteins by oxidizing tyrosine, tryptophan, and cysteine. We reviewed the pathways by which ClO02 reacts with important bio-molecules, as well as the primary target sites at individual cellular level of ClO2-induced biocidal effects. PMID:22799207

  3. 78 FR 42086 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    2013-07-15

    ... and achievable with the use of good manufacturing practices. It also describes FDA's intended sampling... to be protective of human health and to be achievable with the use of good manufacturing practices... with FDA's good guidance practices regulation (21 CFR 10.115). The draft guidance, when finalized,...

  4. Crystalline Repository Project: Review and comment of the Leech Lake Reservation Business Committee: Draft area recommendation report

    The Leech Lake Reservation Business Committee (LLRBC) has reviewed five documents related to the US Department of Energy's Crystalline Repository Project (CRP). They are the ''National Survey of Crystalline Rocks,'' ''General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories;' Final Siting Guidelines (10 CFR Part 960),'' ''Regional Characterization Reports for the North Central Region,'' the ''Region to Area Screening Methodology Document'' (SMD) and the ''Draft Area Recommendation Report'' (DARR). The comments and discussions of issues contained in this review will be considered in the preparation of the Final Area Recommendation Report, which will formally identify potentially acceptable sites for a second national repository for the permanent disposal of high level nuclear waste. Following a review of the above referenced documents, the LLRBC has concluded that the identification of potentially acceptable sites in the Draft Area Recommendation Report is based upon inferior and incomplete technical information being applied to a flawed screening process which, among other deficiencies, pays little attention to the importance of hydrological factors in the siting process. Although the DOE prefers that comments from states and tribes be directed at the Draft Area Recommendation Report alone, the Leech Lake Reservation Business Committee is extremely concerned about inadequacies in the ''National Survey of Crystalline Rocks'' (ORCD-1), which serves as the foundation for all siting work done to date. The national survey was conducted utilizing little of the time or staffing required for this important phase of the Crystalline Repository Program. As a result, the national survey is based upon out-of-date scientific literature, exaggerates certain screening variables that favor the selection of regions in the eastern US and arbitrarily eliminated the few western crystalline rock bodies that passed the questionable screening process utilized

  5. A scoping review of definitions and frameworks of intersectoral action.

    Dubois, Alejandra; St-Pierre, Louise; Veras, Mirella

    2015-10-01

    Intersectoral action is rooted in all health promotion activities because the determinants of health lie outside of the health sector. Despite the increasing use of these terms (intersectoral action, intersectoral action for health, intersectoral collaboration), often interchangeably, we noted a lack of consensus on their definitions and conceptualizations. The objective of this paper is to report the results of a scoping review of the use of definitions for a set of related terms as well as for conceptual frameworks, including the discussion of the evolution of those definitions and the sectors that use them. Finally, we propose a single definition for each term. We conducted a systematic search for documents published between January, 1960 and March, 2011 in English, French, Spanish and Portuguese. We retrieved 11 to 15 definitions per main term. Using a content analysis approach, an integrative conceptual definition was proposed for four main terms. Furthermore, in reviewing frameworks for potential use, we noted the lack of a comprehensive framework for intersectoral processes. PMID:26465838

  6. A scoping review of definitions and frameworks of intersectoral action

    Alejandra Dubois

    2015-10-01

    Full Text Available AbstractIntersectoral action is rooted in all health promotion activities because the determinants of health lie outside of the health sector. Despite the increasing use of these terms (intersectoral action, intersectoral action for health, intersectoral collaboration, often interchangeably, we noted a lack of consensus on their definitions and conceptualizations. The objective of this paper is to report the results of a scoping review of the use of definitions for a set of related terms as well as for conceptual frameworks, including the discussion of the evolution of those definitions and the sectors that use them. Finally, we propose a single definition for each term. We conducted a systematic search for documents published between January, 1960 and March, 2011 in English, French, Spanish and Portuguese. We retrieved 11 to 15 definitions per main term. Using a content analysis approach, an integrative conceptual definition was proposed for four main terms. Furthermore, in reviewing frameworks for potential use, we noted the lack of a comprehensive framework for intersectoral processes.

  7. 75 FR 36371 - Draft Environmental Impact Statement Addressing Campus Development at Fort Meade, MD

    2010-06-25

    ... requirements and for Intelligence Community use. The purpose of the proposed action is to provide facilities that are fully-supportive of the Intelligence Community's mission. The action is driven by the need to... participate in the public review process. The public comment period for the Draft EIS will officially end...

  8. 78 FR 23289 - Public Review of Draft National Shoreline Data Content Standard

    2013-04-18

    ... shoreline semantics, data structures and their relationships to builders and users of shoreline data. The... on the FGDC Web site, www.fgdc.gov . DATES: Comments on the draft Coastal and Marine Ecological... providing technical guidance on shoreline semantics, data structures and their relationships to builders...

  9. BASINS and WEPP Climate Assessment Tools (CAT): Case Study Guide to Potential Applications (External Review Draft)

    This draft report supports application of two recently developed water modeling tools, the BASINS and WEPP climate assessment tools. The report presents a series of short case studies designed to illustrate the capabilities of these tools for conducting scenario based assessments...

  10. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Second External Review Draft, 2015)

    This draft document provides EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of oxides of nitrogen. When final, it will provide a critical part of the scientific foundation for EPA’s decision regarding the adequacy of the current ...

  11. Scales, strategies and actions for effective energy planning: A review

    This paper is a review of the most recent literature on the interaction between climate change, land-use and energy, based on the analysis of papers collected through the most relevant scientific literature databases. A total of 114 papers published between 2000 and 2011 were reviewed. The aims of this review are: in general (1) to identify the different research topics that have been developed related to the interaction between climate change, land-use and energy; more specifically, (2) to analyze what are the most suitable spatial and temporal scales of investigation to focus on for actions and strategies to reduce critical issues in the field of energy and environment; (3) to identify which actions and strategies are deemed as the most appropriate to mitigate critical issues in energy and environment; and given the research gaps found in the review, (4) to propose research recommendations in the context of effective climate-energy planning. We argue that there are certain gaps and needs for a “nested” environmental governance. It is necessary to understand how different environmental policies overlap and how they can be integrated in order to verify whether there are conflicting targets that may negate each other in the long term. - Highlights: • Energy production and consumption can directly or indirectly affect climate change. • Energy sector is influenced directly and indirectly by changes in climate conditions. • Energy sector and climate change affect and limit alternative uses of land, causing land-use changes. • The most suitable spatial scale for energy planning is the municipal level requiring short-term perspectives. • Several research recommendations to deal with the complexity of energy-land-use-climate change issue are proposed

  12. Corrective Action Investigation Plan for Corrective Action Unit 556: Dry Wells and Surface Release Points Nevada Test Site, Nevada (Draft), Revision 0

    Grant Evenson

    2007-02-01

    Corrective Action Unit  (CAU) 556, Dry Wells and Surface Release Points, is located in Areas 6 and 25 of the Nevada Test Site, 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 556 is comprised of four corrective action sites (CASs) listed below: •06-20-04, National Cementers Dry Well •06-99-09, Birdwell Test Hole •25-60-03, E-MAD Stormwater Discharge and Piping •25-64-01, Vehicle Washdown and Drainage Pit These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  13. Towards new educational potentialities: Review and commentary of the Preliminary draft Act on higher education

    Madžar Ljubomir

    2005-01-01

    Full Text Available The Higher Education Act is a long-awaited legal act. A number of uncompleted attempts to prepare it have been undertaken in the course of the last three years. So far without success. Having been and still being a matter of highest social priority, the renewed effort to create and subsequently to enact this act is welcome as a worthwhile and a highly productive endeavor. Welcome also are the main innovations offered by this act, particularly its conspicuous consistency with the Bologna Declaration and other internationally launched and accepted documents. The draft act follows the international documents tracing down the paths of the future development of the educational systems of the European countries and providing for their mutual compatibility. A number of other positive contributions of the draft act are singled out, such as introducing clear and rigorous criteria and procedures for accreditation and quality control, introducing a wide coverage of arts and sciences as a precondition for an institution of higher education to qualify as a university, flexibility in the regime of studying including the domestic and international mobility of the students and requirement for the schools of higher education to have large cores of permanently employed teaching staff. A much larger part of the paper is, however, devoted to critical commentaries. To begin with, the draft is produced without any participation of the private universities, which is seen as a form of discrimination. The organizational pattern of a university is laid out with insufficient clarity and the status of departments (faculties is particularly short of precision and even contradictory. The draft seems to be laden with the old bias towards excessive and potentially disastrous centralization, drastically reducing the decision making capacity of the system. The treatment of the property of the departments (faculties is found inconsistent and legally unfounded. Inconsistency is

  14. 75 FR 81643 - Hydropower Resource Assessment at Existing Reclamation Facilities-Draft Report

    2010-12-28

    ..., 2010 (75 FR 67993). The public review period was originally to end on December 6, 2010. DATES: Submit... Bureau of Reclamation Hydropower Resource Assessment at Existing Reclamation Facilities--Draft Report AGENCIES: Bureau of Reclamation, Interior. ACTION: Reopening of comment period for review of the...

  15. Multitarget stool DNA for colorectal cancer screening: A review and commentary on the United States Preventive Services Draft Guidelines

    Berger, Barry M; Levin, Bernard; Hilsden, Robert J

    2016-01-01

    Multitarget stool DNA (mt-sDNA) testing was approved for average risk colorectal cancer (CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program (2014). The United States Preventive Services Task Force (USPSTF) October 2015 draft recommendation for CRC screening included mt-sDNA as an “alternative” screening test that “may be useful in select clinical circumstances”, despite its very high sensitivity for early stage CRC. The evidence supporting mt-sDNA for routine screening use is robust. The clinical efficacy of mt-sDNA as measured by sensitivity, specificity, life-years gained (LYG), and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document, especially those requiring annual testing adherence. In a population with primarily irregular screening participation, tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence. This paper reviews the evidence supporting mt-sDNA for routine screening and demonstrates, using USPSTF’s modeling data, that mt-sDNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing, high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. PMID:27190584

  16. Lessons learned from the preclosure performance assessment review of the Fluor Technology, Inc., draft site characterization plan conceptual design report

    This report presents the lessons learned from the preclosure performance assessment review (PAR) of the Draft Site Characterization Plan---Conceptual Design Report (SCP-CDR). The PAR analyzes the operations of the waste handling facilities as presented in the SCP-CDR against appropriate regulatory and design criteria. The PAR applies to the design presented in a working draft released in April, 1986. We will analyze the design presented in the SCP-CDR, the other is to test safety assessment methods and tools. This report addresses only the second of these objectives. The PAR analysis consists of assessments of offsite and occupational doses resulting from routine and accidental events during preclosure operations at the repository. The activities related to the PAR are divided into subject areas. These areas include (1) the description of repository facilities and operations, (2) the development of radioactive material inventories and radiation dose rates, (3) the development of radioactive material-release scenarios and source terms, (4) the assessment of offsite dose equivalents, and (5) the assessment of occupational radiation dose equivalents. This report contains a summary of the analyses in these fives areas and lists those preclosure analyses not performed as part of the PAR. Chapters detail the strengths and weaknesses of each analysis and include recommendations for improving the analyses. 15 refs., 1 fig., 1 tab

  17. Plan of Action: JASPER Management Prestart Review (Surrogate Material Experiments)

    undergone appropriate formal engineering design reviews. This MPR will affirm the quality of those reviews, their findings/resolutions, and will look most closely at systems integration requirements and demonstrations that will have undergone technical acceptance reviews before the formal MPR action. Closure of MPR findings will finalize requirements for a DOE/NV Real Estate/Operations Permit (REOP) for surrogate-material experiments. Upon completion of that experiment series and the establishment of capabilities for incorporating SNM into future experiments, the team will convene again as part of the process of authorizing those activities

  18. IRSN review 2011/2014. Openness to society - Review of actions, 5 years after the chart

    After having recalled the commitments defined by the Charter for Openness to Society adopted by the IRSN in 2009, this report proposes a review of undertaken and performed actions in terms of access to information, of openness to partnership (notably with local information commissions or CLIs, and also with other local actors), of influence of the openness on the Institute work orientation, and of internal culture of openness

  19. Standard review plan for the review of environmental restoration remedial action quality assurance program plans

    This plan establishes both the scope of the review and the acceptance criteria to be utilized for the review of Quality Assurance Program Plans (QAPPs) developed in accordance with the requirements of DOE/RL-90-28. DOE/RL-90-28, the Environmental Restoration Remedial Action Quality Assurance Requirements Document (QARD) defines all quality assurance (QA) requirements governing activities that affect the quality of the Environmental Restoration Remedial Action (ERRA) program at the Hanford Site. These requirements are defined in three parts, Part 1 of Quality Management and Administration tasks, Part 2 for Environmental Data Operations, and Part 3 of the Design and Construction of items, systems, and facilities. The purpose of this document is to identify the scope of the review by the DOE Field Office, Richland staff, and establish the acceptance criteria (Parts 1, 2, and 3) that the DOE Field Office, Richland staff will utilize to evaluate the participant QAPPs. Use of the standard review plan will (1) help ensure that participant QAPPs contain the information required by DOE/RL-90-28, (2) aid program participant and DOE Field Office, Richland staff is ensuring that the information describing the participant's QAPP is complete, (3) help persons regarding DOE/RL- 90-28 to locate information, and (4) contribute to decreasing the time needed for the review process. In addition, the Standard Review Plan (SRP) ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate compliance of participant quality programs against DOE/RL-90-28

  20. Radioactive waste isolation in salt: Peer review of the Golder Associates draft test plan for in situ testing in an exploratory shaft in salt

    This report documents the peer review conducted by Argonne National Laboratory of a document entitled ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared for Battelle Memorial Institute's Office of Nuclear Waste Isolation by Golder Associates, Inc. In general, the peer review panelists found the test plan to be technically sound, although some deficiencies were identified. Recommendations for improving the test plan are presented in this review report. A microfiche copy of the following unpublished report is attached to the inside back cover of this report: ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared by Golder Associates, Inc., for Office of Nuclear Waste Isolation, Battelle Memorial Institute, Columbus, Ohio (March 1985)

  1. Radioactive waste isolation in salt: Peer review of the Golder Associates draft test plan for in situ testing in an exploratory shaft in salt

    Hambley, D.F.; Mraz, D.Z.; Unterberter, R.R.; Stormont, J.C.; Neuman, S.P.; Russell, J.E.; Jacoby, C.H.; Hull, A.B.; Brady, B.H.G.; Ditmars, J.D.

    1987-01-01

    This report documents the peer review conducted by Argonne National Laboratory of a document entitled ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared for Battelle Memorial Institute's Office of Nuclear Waste Isolation by Golder Associates, Inc. In general, the peer review panelists found the test plan to be technically sound, although some deficiencies were identified. Recommendations for improving the test plan are presented in this review report. A microfiche copy of the following unpublished report is attached to the inside back cover of this report: ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared by Golder Associates, Inc., for Office of Nuclear Waste Isolation, Battelle Memorial Institute, Columbus, Ohio (March 1985).

  2. Development of Action Research in China: Review and Reflection

    Zhou, Jun; Liu, Katrina Yan

    2011-01-01

    Action research in China during late 1970s and 1980s was influenced by positivist scientific research, believing the purpose of doing action research is to explore the general law of education. It was carried out through educational experimentations emphasizing the control of the experimental conditions. Starting from 1990s, action research in…

  3. [Draft] Malheur NWR habitat and wildlife management review : November 13-17, 2000

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the findings and recommendations of a wildlife and habitat management review conducted by a review team during November 13-17, 2000 at the...

  4. North Mississippi Refuges Complex Biological Program 'Pulse-Check' Review - DRAFT REPORT

    US Fish and Wildlife Service, Department of the Interior — Biological review for the three refuges of the North Mississippi Refuges Complex is presented. Review is based on an assessment of addressing goals and objectives...

  5. Action Research in Graduate Teacher Education: A Review of the Literature 2000-2015

    Vaughan, Michelle; Burnaford, Gail

    2016-01-01

    This review explores the goals and challenges as well as the policy and programmatic implications of action research in graduate teacher education as evidenced in the published literature. This literature review looks specifically at how action research is being used in graduate teacher education programs as a content area and as a methodology in…

  6. Review Essay: Getting with the Act of Action Research

    Palmer, Victoria J.

    2009-01-01

    Action research (AR) prides itself on being a field of both theoretical and practical inquiry. Its scholarly identity rests heavily on framing participants as engaged, subjective, and participatory beings who learn and change through research processes. Yet, action research struggles to be considered a rigorous methodological field of inquiry and certainly there have been those who have raised questions about its validity as a research method. Where action research is used, qualifications and...

  7. 75 FR 48382 - Draft Regulatory Guide: Issuance, Availability

    2010-08-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1228, ``Standard Format and Content...

  8. 75 FR 28073 - Draft Regulatory Guide: Issuance, Availability

    2010-05-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-3039, ``Standard Format and Content...

  9. 77 FR 33489 - Draft Offender Tracking System Standard

    2012-06-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Draft Offender Tracking System Standard AGENCY: National Institute of Justice. ACTION: Notice of Draft Offender Tracking System Standard, Selection and Application Guide,...

  10. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 8: Aerothermodynamics Automation and Robotics (A/R) systems sensors, high-temperature superconductivity

    Viewgraphs of briefings presented at the SSTAC/ARTS review of the draft Integrated Technology Plan (ITP) on aerothermodynamics, automation and robotics systems, sensors, and high-temperature superconductivity are included. Topics covered include: aerothermodynamics; aerobraking; aeroassist flight experiment; entry technology for probes and penetrators; automation and robotics; artificial intelligence; NASA telerobotics program; planetary rover program; science sensor technology; direct detector; submillimeter sensors; laser sensors; passive microwave sensing; active microwave sensing; sensor electronics; sensor optics; coolers and cryogenics; and high temperature superconductivity

  11. Remedial action plan for the inactive Uranium Processing Site at Naturita, Colorado. Remedial action plan: Attachment 2, Geology report, Attachment 3, Ground water hydrology report: Working draft

    1994-09-01

    The uranium processing site near Naturita, Colorado, is one of 24 inactive uranium mill sites designated to be cleaned up by the US Department of Energy (DOE) under the Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), 42 USC {section}7901 et seq. Part of the UMTRCA requires that the US Nuclear Regulatory Commission (NRC) concur with the DOE`s remedial action plan (RAP) and certify that the remedial action conducted at the site complies with the standards promulgated by the US Environmental Protection Agency (EPA). This RAP serves two purposes. First, it describes the activities that are proposed by the DOE to accomplish remediation and long-term stabilization and control of the radioactive materials at the inactive uranium processing site near Naturita, Colorado. Second, this RAP, upon concurrence and execution by the DOE, the state of Colorado, and the NRC, become Appendix B of the cooperative agreement between the DOE and the state of Colorado.

  12. Remedial action plan for the inactive Uranium Processing Site at Naturita, Colorado. Remedial action plan: Attachment 2, Geology report, Attachment 3, Ground water hydrology report: Working draft

    The uranium processing site near Naturita, Colorado, is one of 24 inactive uranium mill sites designated to be cleaned up by the US Department of Energy (DOE) under the Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), 42 USC section 7901 et seq. Part of the UMTRCA requires that the US Nuclear Regulatory Commission (NRC) concur with the DOE's remedial action plan (RAP) and certify that the remedial action conducted at the site complies with the standards promulgated by the US Environmental Protection Agency (EPA). This RAP serves two purposes. First, it describes the activities that are proposed by the DOE to accomplish remediation and long-term stabilization and control of the radioactive materials at the inactive uranium processing site near Naturita, Colorado. Second, this RAP, upon concurrence and execution by the DOE, the state of Colorado, and the NRC, become Appendix B of the cooperative agreement between the DOE and the state of Colorado

  13. 77 FR 69631 - Draft Guidance for IRBs, Clinical Investigators, and Sponsors: IRB Responsibilities for Reviewing...

    2012-11-20

    ... Reducing Burden, Delay, and Ambiguity for Investigators,'' in the Federal Register of July 26, 2011 (76 FR... Sponsors: IRB Responsibilities for Reviewing the Qualifications of Investigators, Adequacy of Research... Responsibilities for Reviewing the Qualifications of Investigators, Adequacy of Research Sites, and...

  14. THYROID FOLLICULAR CELL CARCINOGENESIS: MECHANISTIC AND SCIENCE POLICY CONSIDERATIONS (SAB REVIEW DRAFT)

    A Technical Panel of EPA's Risk Assessment Forum investigated the potential mechanisms of action of agents that cause thyroid follicular tumors in animals and potentially in humans in an effort to develop a scientifically plausible approach for assessing risk due to exposure to t...

  15. Review and comments on draft final report : environmental impact assessment on the Cambodian part of Srepok River due to hydropower development in Vietnam

    NONE

    2006-10-15

    This environmental impact assessment review was written by a coalition of partners working to support communities along the Sesan, Srepok, and Sekong Rivers in Cambodia. The review assessed the adequacy of the draft final report on the environmental impacts of a hydropower development in Vietnam on downstream communities in Cambodia. The review also examined methods of developing compensation and mitigation measures to alleviate negative impacts of the hydropower facility, and evaluated the adequacy of the report for advancing negotiations and consultations and mitigation strategies along the lower Srepok River in Cambodia. The review examined economic losses, the effects of water pollution, disease, water fluctuations, and floods. The review demonstrated that the EIA failed to demonstrate that downstream impacts are manageable or that the benefits of the proposed project outweigh the total cost. It was recommended that the draft final report should be made available for public review in Cambodia. It was concluded that alternative dam designs and operating scenarios for the Vietnamese project should be considered. 6 tabs.

  16. Environmental assessment of remedial action at the Slick Rock uranium mill tailings sites Slick Rock, Colorado. Draft

    NONE

    1993-06-01

    The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA) authorized the US Department of Energy (DOE) to clean up two uranium mill tailings processing sites near Slick Rock, Colorado, in San Miguel County. The purpose of the cleanup is to reduce the potential health effects associated with the radioactive materials remaining on the sites and on vicinity properties (VP) associated with the sites. The US Environmental Protection Agency (EPA) promulgated standards for the UMTRCA that contained measures to control the contaminated materials and to protect the groundwater from further degradation. Remedial actions at the Slick Rock sites must be performed in accordance with these standards and with the concurrence of the US Nuclear Regulatory Commission (NRC).

  17. Radioactive waste isolation in salt: Peer review of the Office of Nuclear Waste Isolation's draft report on an issues hierarchy and data needs for site characterization

    At the request of the Salt Repository Project (SRPO), Argonne National Laboratory conducted an independent peer review of a report by the Battelle Office of Nuclear Waste Isolation entitled ''Salt Repository Project Issues Hierarchy and Data Needs for Site Characterization (Draft).'' This report provided a logical structure for evaluating the outstanding questions (issues) related to selection and licensing of a site as a high-level waste repository. It also provided a first estimate of the information and data necessary to answer or resolve those questions. As such, this report is the first step in developing a strategy for site characterization. Microfiche copies of ''Draft Issues Hierarchy, Resolution Strategy, and Information Needs for Site Characterization and Environmental/Socioeconomic Evaluation - July, 1986'' and ''Issues Hierarchy and Data Needs for Site Characterization - February, 1985'' are included in the back pocket of this report

  18. Geochemistry Review Panel report on the SRP geochemistry program and draft geochemistry summary program plan (May, 1986) and discussion of panel recommendations

    The Geochemistry Review Panel (GRP) was established by the Salt Repository Project Office (SRPO) to help evaluate geochemistry-related issues in the US Department of Energy's nuclear waste repository program. The May 1986 meeting of the GRP reviewed the Salt Repository Program (SRP) geochemistry program developed by the Office of Nuclear Waste Isolation (ONWI). This program is described in the Draft Geochemistry Plan of April 9, 1986. This report documents the GRP's comments and recommendations on this subject and the ONWI responses to the specific points raised by the GRP

  19. Review and assessments of potential environmental, health and safety impacts of MHD technology. Final draft

    1978-01-01

    The purpose of this document is to develop an environmental, health and safety (EH and S) assessment and begin a site - specific assessment of these and socio - economic impacts for the magnetohydrodynamics program of the United States Department of Energy. This assessment includes detailed scientific and technical information on the specific EH and S issues mentioned in the MHD Environmental Development Plan. A review of current literature on impact-related subjects is also included. This document addresses the coal-fired, open-cycle MHD technology and reviews and assesses potential EH and S impacts resulting from operation of commercially-installed technology.

  20. [Review of draft Crystalline Repository Project reports]: Technical progress report, CY 1985-1986

    During the period (CY 1985-86) of this report, the Wisconsin Radioactive Waste Review Board provided technical services under the contract with DOE. These included Participation in the development of variables and screening techniques that would be used in identifying those rock bodies in the Area Recommendation Report (ARR); reviewing and commenting on the report and developing a procedure in which local residents could have input into the process; sought resumption of negotiations with DOE on a full Consultation and Cooperation (CandC) agreement; and Participating in workshops and provided comments on two major DOE transportation documents, ''Transportation Business Plan: Strategy Options Document,'' and ''Transportation Institutional Plan.''

  1. 78 FR 21618 - Mortgagee Review Board: Administrative Actions

    2013-04-11

    ...] 117. Right Mortgage Company, Lebanon, TN 118. Rokitto Enterprises, Porter Ranch, CA 119. Sacramento..., Probations, Reprimands, and Administrative Payments 1. Academy Mortgage Corporation, Sandy, UT Action: On April 27, 2012, the Board entered into a Settlement Agreement with Academy Mortgage Corporation...

  2. Human-system interface design review guideline: The development of draft revision 1 to NUREG-0700

    O`Hara, J.; Stubler, W.; Brown, W. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1996-03-01

    Advanced human-system interface (HSI) technologies are being developed in the commercial nuclear power industry. These HSIs may have significant implications for plant safety in that they will affect the ways in which the operator interacts with and supervises an increasingly complex system. The U.S. Nuclear Regulatory Commission (NRC) reviews the HSI aspects of nuclear plants to ensure that operator performance and reliability are supported. The NRC is developing guidance to support its review of these advanced designs. The guidance consists of an evaluation methodology and an extensive set of human factors guidelines which are used in one aspect of the evaluation. The paper describes the guidance development of the evaluation methodology and the guidelines.

  3. Community Addiction Response Programme CARP Killinarden: review and interim evaluation report, final revised draft.

    Bowden, Matt

    1997-01-01

    Funded by the Combat Poverty Agency, this report presented a review and evaluation of the Community Addiction Response Programme (CARP) in Killinarden, Tallaght, in south-west Dublin. The report examined the historical background to the programme and looked at its development as a particular response to the issue of drug misuse in the area. Data were gathered using internal documentation, such as reports, proposals and minutes; semi-structured interviews with staff, team members, professional...

  4. 76 FR 77492 - Draft Guidance on Improving the Process for Preparing Efficient and Timely Environmental Reviews...

    2011-12-13

    ...,563, 76 FR 3821 (January 21, 2011), available at http://www.gpo.gov/fdsys/pkg/FR-2011-01-21/pdf/2011... Regulation and Regulatory Review,'' Exec. Order 13,563, 76 FR 3821 (January 21, 2011), available at http://www.gpo.gov/fdsys/pkg/FR-2011-01-21/pdf/2011-1385.pdf . \\4\\ This guidance is not a rule or...

  5. Review of restrictive actions under the Australian drug regulatory system.

    Dukes, M N; Lunde, I

    1982-05-15

    An analysis of restrictive measures taken by the Australian Drug Evaluation Committee (ADEC) over the period of 27 months (from March, 1976, to June, 1978) was made by two non-Australian observers. During this period, the ADEC took 32 useful restrictive measures (a little more than one a month). The analysis was limited only to cases in which ADEC took substantial action; if less comprehensive measures were included, the number of valid actions to counter the occurrence of iatrogenic complications would be much greater. It is concluded that, although it is an undisputed fact that many pharmaceutical companies maintain the highest ethical standards, there is a need for the type of objective and dispassionate control exercised by the Australian Drug Evaluation Committee. PMID:7099069

  6. Five-Year Review of CERCLA Response Actions at the Idaho National Laboratory

    W. L. Jolley

    2007-02-01

    This report summarizes the documentation submitted in support of the five-year review or remedial actions implemented under the Comprehensive Environmental Response, Compensation, and Liability Act Sitewide at the Idaho National Laboratory. The report also summarizes documentation and inspections conducted at the no-further-action sites. This review covered actions conducted at 9 of the 10 waste area groups at the Idaho National Laboratory, i.e. Waste Area Groups 1, 2, 3, 4, 5, 6, 7, 9, and 10. Waste Area Group 8 was not subject to this review, because it does not fall under the jurisdiction of the U.S. Department of Energy Idaho Operations Office. The review included past site inspections and monitoring data collected in support of the remedial actions. The remedial actions have been completed at Waste Area Groups 2, 4, 5, 6, and 9. Remedial action reports have been completed for Waste Area Groups 2 and 4, and remedial action reports are expected to be completed during 2005 for Waste Area Groups 1, 5, and 9. Remediation is ongoing at Waste Area Groups 3, 7, and 10. Remedial investigations are yet to be completed for Operable Units 3-14, 7-13/14, and 10-08. The review showed that the remedies have been constructed in accordance with the requirements of the Records of Decision and are functioning as designed. Immediate threats have been addressed, and the remedies continue to be protective. Potential short-term threats are being addressed though institutional controls. Soil cover and cap remedies are being maintained properly and inspected in accordance with the appropriate requirements. Soil removal actions and equipment or system removals have successfully achieved remedial action objectives identified in the Records of Decision. The next Sitewide five-year review is scheduled for completion by 2011.

  7. Conducting need-for-power review for nuclear power plants: guidelines to states. Draft report

    The report is intended to describe the state regulatory commissions and other state agencies the standards and criteria used by NRC in conducting need-for-power evaluations for the licensing of nuclear power plants. These are intended as guidelines to states which may wish to perform a need-for-power review that will suffice for adoption by the NRC in its licensing process. Three methodologies which have been used for need-for-power evaluations and which meet NRC standards are included

  8. [Support system to the process of risk assessment in construction company: assessment, drafting, and review].

    Ramenghi, D; Golferini, M

    2012-01-01

    The aim of this study is provide a tool for perrforming risk assessment, a methodology for completing the risk assessment document and a support tool to objectively review the Risk Assessment Document (RAD) in order to its improvement. Starting from a series of documents available such as legislation, literature, best practices, guidelines, and evaluating the documents of 10 construction companies, has been defined list of content needed to RAD. In conclusion, we have implemented a support system organized into chapters that allow the Employer/competent doctor compiling/evaluating the DVR. PMID:23405703

  9. Peer Review Documents Related to the Evaluation of Benchmark Dose Software (BMDS) (External Review Draft, version 1.1b)

    BMDS is one of the Agency's premier tools for estimating risk assessments, therefore the validity and reliability of its statistical models are of paramount importance. This page provides links to peer review and expert summaries of the BMDS application and its models as they wer...

  10. 19 CFR 207.63 - Circulation of draft questionnaires.

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review....

  11. 77 FR 69619 - Draft Recommendations of Joint Outreach Team

    2012-11-20

    ... Area Power Administration Draft Recommendations of Joint Outreach Team AGENCY: Western Area Power Administration, DOE. ACTION: Notice of Availability of draft recommendations of Western/DOE Joint Outreach Team... Department of Energy (DOE), is publishing the draft recommendations of the Western/DOE Joint Outreach...

  12. 75 FR 9613 - Draft NIJ Restraints Standard for Criminal Justice

    2010-03-03

    ... of Justice Programs Draft NIJ Restraints Standard for Criminal Justice AGENCY: National Institute of Justice, Office of Justice Programs, DOJ. ACTION: Notice of Draft NIJ Restraints Standard for Criminal... Restraints Standard for Criminal Justice'' and (2) a draft companion document entitled, ``NIJ...

  13. Implementation Plan for the Hawaii Geothermal Project Environmental Impact Statement (DOE Review Draft:)

    None

    1992-09-18

    The US Department of Energy (DOE) is preparing an Environmental Impact Statement (EIS) that identifies and evaluates the environmental impacts associated with the proposed Hawaii Geothermal Project (HGP), as defined by the State of Hawaii in its 1990 proposal to Congress (DBED 1990). The location of the proposed project is shown in Figure 1.1. The EIS is being prepared pursuant to the requirements of the National Environmental Policy Act of 1969 (NEPA), as implemented by the President's Council on Environmental Quality (CEQ) regulations (40 CFR Parts 1500-1508) and the DOE NEPA Implementing Procedures (10 CFR 1021), effective May 26, 1992. The State's proposal for the four-phase HGP consists of (1) exploration and testing of the geothermal resource beneath the slopes of the active Kilauea volcano on the Island of Hawaii (Big Island), (2) demonstration of deep-water power cable technology in the Alenuihaha Channel between the Big Island and Mau, (3) verification and characterization of the geothermal resource on the Big Island, and (4) construction and operation of commercial geothermal power production facilities on the Big Island, with overland and submarine transmission of electricity from the Big Island to Oahu and possibly other islands. DOE prepared appropriate NEPA documentation for separate federal actions related to Phase 1 and 2 research projects, which have been completed. This EIS will consider Phases 3 and 4, as well as reasonable alternatives to the HGP. Such alternatives include biomass coal, solar photovoltaic, wind energy, and construction and operation of commercial geothermal power production facilities on the Island of Hawaii (for exclusive use on the Big Island). In addition, the EIs will consider the reasonable alternatives among submarine cable technologies, geothermal extraction, production, and power generating technologies; pollution control technologies; overland and submarine power transmission routes; sites reasonably suited to

  14. 24 CFR 597.300 - HUD action and review of nominations for designation.

    2010-04-01

    ... required by § 597.202(b). (c) Evaluation of nominations. In the process of reviewing each nomination... ENTERPRISE COMMUNITIES: ROUND ONE DESIGNATIONS Designation Process § 597.300 HUD action and review of... by this part. HUD will notify the State(s) and local government(s) whether or not the nomination...

  15. 5 CFR 1201.161 - Action by the Equal Employment Opportunity Commission; judicial review.

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Action by the Equal Employment Opportunity Commission; judicial review. 1201.161 Section 1201.161 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES AND PROCEDURES Procedures for Cases Involving Allegations of Discrimination Review of...

  16. Development and verification for review plan of emergency action level (EAL)

    Emergency action levels (EALs) are used as the trigger in order to implement the precautionary protective actions at the nuclear emergency. In this study the framework for applying the EAL in Japan and the process for developing the review plan, such as procedures to review the basis of EAL submitted by the licensee, have been investigated based on the survey for EAL review executed in the United States. In addition, issues to reflect the EAL framework in enhancement of the local government emergency planning and emergency response support system have been investigated. (author)

  17. Design and analysis of field studies with bees: A critical review of the draft EFSA guidance.

    Bakker, Frank

    2016-07-01

    The specific protection goal, primary assessment endpoints, acceptable effect thresholds, and experimental design proposed in the European Food Safety Authority (EFSA) update of the bee guidance document are subjected to critical review. It is concluded that the negligible effect criteria were established without sufficient regulatory definition and without convincing scientific argumentation. For the assessment endpoints, effects on hive strength lack temporal definition and the reduction to numbers of bees is inappropriate to evaluate effects. Restricting mortality assessments to homing failure is not theoretically justified and specific criteria were incorrectly derived. The combination of acute effect estimates with models for chronic stressors is biased risk assessment and a temporal basis for the acceptability of effects is missing. Effects on overwintering success cannot be experimentally assessed using the proposed criteria. The experimental methodology proposed is inappropriate and the logistical consequences, in particular those related to replication and land use are such that field studies are no longer a feasible option for the risk assessment. It may be necessary to explore new lines of thought for the set-up of field studies and to clearly separate experimentation from monitoring. Integr Environ Assess Manag 2016;12:422-428. © 2015 SETAC. PMID:26436642

  18. 77 FR 76000 - Notice of Availability of Draft Report of the NOAA Research and Development Portfolio Review Task...

    2012-12-26

    ... SAB was also asked to provide advice on an appropriate organizational approach, within NOAA, for support of this R&D portfolio. NOAA welcomes all comments on the content of the draft report. We also request comments on any perceived inconsistencies within the report, and possible omissions of...

  19. 76 FR 54227 - Draft Toxicological Review of n-Butanol: In Support of Summary Information on the Integrated Risk...

    2011-08-31

    ...) within the EPA Office of Research and Development (ORD). EPA is releasing this draft assessment solely..., contact information, any sponsorship information, whether you will be a speaker or an observer, and if you... Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, NW., Washington, DC...

  20. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Public Comment Draft)

    EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database.

  1. Reviewing Biosphere Reserves globally: effective conservation action or bureaucratic label?

    Coetzer, Kaera L; Witkowski, Edward T F; Erasmus, Barend F N

    2014-02-01

    The Biosphere Reserve (BR) model of UNESCO's Man and the Biosphere Programme reflects a shift towards more accountable conservation. Biosphere Reserves attempt to reconcile environmental protection with sustainable development; they explicitly acknowledge humans, and human interests in the conservation landscape while still maintaining the ecological values of existing protected areas. Conceptually, this model is attractive, with 610 sites currently designated globally. Yet the practical reality of implementing dual 'conservation' and 'development' goals is challenging, with few examples successfully conforming to the model's full criteria. Here, we review the history of Biosphere Reserves from first inception in 1974 to the current status quo, and examine the suitability of the designation as an effective conservation model. We track the spatial expansion of Biosphere Reserves globally, assessing the influence of the Statutory Framework of the World Network of Biosphere Reserves and Seville strategy in 1995, when the BR concept refocused its core objectives on sustainable development. We use a comprehensive range of case studies to discuss conformity to the Programme, the social and ecological consequences associated with implementation of the designation, and challenges in aligning conservation and development. Given that the 'Biosphere Reserve' label is a relatively unknown designation in the public arena, this review also provides details on popularising the Biosphere Reserve brand, as well as prospects for further research, currently unexploited, but implicit in the designation. PMID:23701641

  2. Drafting Fundamentals. Drafting Module 1. Instructor's Guide.

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. The guide contains a cross-reference table of instructional materials. Ten units cover drafting fundamentals: (1) introduction to drafting; (2) general safety;…

  3. Implementation of evidence-based practice in nursing using action research: a review

    Munten, Guus; Bogaard, Joop van den; Cox, Karen; Garretsen, Henk; Bongers, Inge

    2010-01-01

    As is often reported in the literature exploring the research-practice gap, applying the principles of evidence-based practice is easier said than done. Action research is a methodology with an explicit intent of linking the worlds of research and practice. This review attempts to answer the questio

  4. EU-stress test: Swiss national action plan. Follow-up of peer review 2012 year-end status report

    NONE

    2012-12-15

    The European Union (EU) stress test is part of the review process which Switzerland initiated immediately after the reactor accident in Japan. As a direct consequence of the accident, the Swiss Federal Nuclear Safety Inspectorate (ENSI) issued three formal orders in which the operators of the Swiss nuclear power plants (NPPs) were required to implement immediate measures and to conduct additional reassessments. The immediate measures comprised the establishment of an external emergency storage facility for the Swiss NPPs, including the necessary plant-specific connections, and back-fittings to provide external injection into the spent fuel pools. The additional reassessments focused on the design of the Swiss NPPs against earthquakes, external flooding and a combination thereof. Investigations on the coolant supply for the safety systems and the spent fuel pool cooling were also requested. ENSI carried out an analysis of the events at Fukushima providing detailed descriptions of the causes, consequences and radiological impacts of the accident. The reports analyse the contributory human and organisational factors, and specify lessons that can be derived from this information. ENSI instructed the Swiss operators to take part in the EU stress test. There was to be particular examination of the robustness of the NPPs in case of impacts beyond the design basis due to earthquakes, external flooding and extreme weather conditions, with consequential loss of power supply and heat sink, and the need for severe accident management actions. ENSI requested further clarification on plant specific issues and produced the National Report which was delivered to the EU Commission. A Country Peer Review Draft Report was drawn up for each country, including a list of issues (open points) for further follow-up by the review team. Eight new open points were identified to further improve the safety of the Swiss NPPs. These open points together with the issues identified in the analysis

  5. EU-stress test: Swiss national action plan. Follow-up of peer review 2012 year-end status report

    The European Union (EU) stress test is part of the review process which Switzerland initiated immediately after the reactor accident in Japan. As a direct consequence of the accident, the Swiss Federal Nuclear Safety Inspectorate (ENSI) issued three formal orders in which the operators of the Swiss nuclear power plants (NPPs) were required to implement immediate measures and to conduct additional reassessments. The immediate measures comprised the establishment of an external emergency storage facility for the Swiss NPPs, including the necessary plant-specific connections, and back-fittings to provide external injection into the spent fuel pools. The additional reassessments focused on the design of the Swiss NPPs against earthquakes, external flooding and a combination thereof. Investigations on the coolant supply for the safety systems and the spent fuel pool cooling were also requested. ENSI carried out an analysis of the events at Fukushima providing detailed descriptions of the causes, consequences and radiological impacts of the accident. The reports analyse the contributory human and organisational factors, and specify lessons that can be derived from this information. ENSI instructed the Swiss operators to take part in the EU stress test. There was to be particular examination of the robustness of the NPPs in case of impacts beyond the design basis due to earthquakes, external flooding and extreme weather conditions, with consequential loss of power supply and heat sink, and the need for severe accident management actions. ENSI requested further clarification on plant specific issues and produced the National Report which was delivered to the EU Commission. A Country Peer Review Draft Report was drawn up for each country, including a list of issues (open points) for further follow-up by the review team. Eight new open points were identified to further improve the safety of the Swiss NPPs. These open points together with the issues identified in the analysis

  6. 77 FR 8262 - Draft Guidance on Investigational New Drug Applications for Positron Emission Tomography Drugs...

    2012-02-14

    ... Positron Emission Tomography Drugs; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... entitled ``Investigational New Drug Applications for Positron Emission Tomography (PET) Drugs.'' The draft... Applications for Positron Emission Tomography (PET) drugs.'' The draft guidance summarizes the IND process...

  7. 75 FR 41452 - Draft Guidance, “Federal Greenhouse Gas Accounting and Reporting”

    2010-07-16

    ... Leadership in Environmental, Energy, and Economic Performance (74 FR 52117) in order to establish an... QUALITY Draft Guidance, ``Federal Greenhouse Gas Accounting and Reporting'' AGENCY: Council on Environmental Quality. ACTION: Notice of Availability, Draft Guidance, ``Federal Greenhouse Gas Accounting...

  8. Peer-review study of the draft handbook for human-reliability analysis with emphasis on nuclear-power-plant applications, NUREG/CR-1278

    This report describes a peer review of the draft Handbook for Human Reliability Analysis with Emphasis on Nuclear Power Plant Applications, NUREG/CR-1278. The purpose of the study was to determine to what extent peers agree with the human behavior models and estimates of human error probabilities (HEPs) contained in the Handbook. Twenty-nine human factors experts participated in the study. Twenty of the participants were Americans; nine were from other countries. The peers performed human reliability analyses of a variety of human performance scenarios describing operator activities in nuclear power plant settings. They also answered questionnaires pertaining to the contents and application of the Handbook. An analysis of peer solutions to the human reliability analysis problems and peer responses to the questionnaire was performed. Recommendations regarding the format and contents of the Handbook were developed from the study findings

  9. 75 FR 80496 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    2010-12-22

    ...), lindane, oleic acid sulfonates, potassium permanganate, and zinc silicate. These pesticides do not...)ethylamine, lindane, oleic acid sulfonates, potassium permanganate, and zinc silicate because these... for registration review. The revised work plan has removed a leaching/ migration...

  10. Combined action of pesticides towards aquatic organisms; a review of available literature from 1972-1998

    Deneer, J.W.

    2000-01-01

    Literature from 1972 to 1998 was critically reviewed and used to assess to what degree the concept of concentration addition can correctly predict the acute toxicity of mixtures of pesticides towards aquatic organisms. For more than 90% of 202 mixtures in 26 studies concentration addition predicted the observed toxicity within a factor of 2. There were no apparent differences between mixtures of compounds with similar or dissimilar toxic modes of action. Deviations from concentration addition...

  11. 45 CFR 2540.640 - When will the reviewing official make a decision on the proposed action?

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false When will the reviewing official make a decision... or Misleading Statements § 2540.640 When will the reviewing official make a decision on the proposed action? The reviewing official will issue a decision within 45 days of receipt of your response....

  12. 45 CFR 60.10 - Reporting negative actions or findings taken by peer review organizations or private...

    2010-10-01

    ... peer review organizations or private accreditation entities. 60.10 Section 60.10 Public Welfare... negative actions or findings taken by peer review organizations or private accreditation entities. (a) What..., dentist, or entity by a peer review organization or private accreditation entity. The health...

  13. Radiological health review of the Draft Environmental Impact Statement (DOE/EIS-0026-D) Waste Isolation Pilot Plant, US Department of Energy. Report EEG-3

    This review of radiological health considerations contains a number of concerns, questions and recommendations that should be addressed by the Department of Energy in the final Environmental Impact Statement (EIS) for the Waste Isolation Pilot Plant (WIPP). Using the assumptions contained in the Draft Environmental Impact Statement (DEIS), the Environmental Evaluation Group (EEG) calculated a number of radiation doses and the results were found to be in general agreement with those presented in the DEIS. The doses resulting from the operational and long-range releases from WIPP to the general population are no more than a fraction of existing radiation doses to the public. However, there are a number of technical considerations in the assessment of radiation exposure that were not adequately evaluated in the DEIS. They are discussed in this review. A number of additional dosage estimates have been identified that need to be calculated by both DOE and EEG. As the DEIS did not contain estimates of the amounts of radioactivity to be permanently located in the repository, it was necessary to calculate these amounts. Health effects, transportation, waste acceptance criteria, site evaluation, site selection criteria, operational exposure, the experimental waste program, long term radiation releases, retrievability, and decommissioning are the categories of the DEIS which were evaluated

  14. 78 FR 70047 - Request for the Technical Review of 25 Draft Skin Notation Assignments and Skin Notation Profiles

    2013-11-22

    ... Skin Notation Assignments and Skin Notation Profiles AGENCY: National Institute for Occupational Safety... Human Services (HHS). ACTION: Request for comments. SUMMARY: The National Institute for Occupational..., such as airway hyper reactivity (asthma). Candidate chemicals may be assigned more than one...

  15. 76 FR 72725 - Draft License Renewal Interim Staff Guidance LR-ISG-2011-05: Ongoing Review of Operating Experience

    2011-11-25

    ... Guidance (LR-ISG), LR-ISG-2011-05, ``Ongoing Review of Operating Experience.'' This LR-ISG provides... on how the ongoing review of operating experience should be used to ensure the effectiveness of the... their programmatic activities for operating experience reviews are appropriate for considering...

  16. A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin

    Gaurang P Mavani

    2015-03-01

    Full Text Available The pressor and antidiuretic actions of arginine vasopressin (AVP have been well documented. This review focuses on the less widely appreciated actions of AVP which also have important physiologic functions and when better understood may provide important insights into common disease states. These actions include effects on pain perception and bone structure as well as important relationships to the varied components of metabolic syndrome. These include effects on blood glucose, lipid levels, and blood pressure. AVP may also play a role in the progression of chronic kidney disease and effect physiologic changes relating to aging, abnormal social behavior and cognitive function. Important cellular responses including cell proliferation, inflammation and control of infection and their relationship to AVP are described. Finally, the effects of AVP on hemostasis and the hypothalamic-pituitary-adrenal access are noted. The goal of this summary of the various actions of AVP is to direct attention to the potential benefits of research in these underemphasized areas of importance.

  17. ICLUS Tools and Datasets (Version 1.2) and User's Manual: Arcgis Tools and Datasets for Modeling US Housing Density (External Review Draft)

    This draft Geographic Information System (GIS) tool can be used to generate scenarios of housing-density changes and calculate impervious surface cover for the conterminous United States. A draft User’s Guide accompanies the tool. This product distributes the population project...

  18. Draft audit report, human factors engineering control room design review: Saint Lucie Nuclear Power Plant, Unit No. 2

    A human factors engineering preliminary design review of the Saint Lucie Unit 2 control room was performed at the site on August 3 through August 7, 1981. This design review was carried out by a team from the Human Factors Engineering Branch, Division of Human Factors Safety. This report was prepared on the basis of the HFEB's review of the applicant's Preliminary Design Assessment and the human factors engineering design review/audit performed at the site. The review team included human factors consultants from BioTechnology, Inc., Falls Church, Virginia, and from Lawrence Livermore National Laboratory (University of California), Livermore, California

  19. Actions, topological terms and boundaries in first order gravity: A review

    Corichi, Alejandro; Vukasinac, Tatjana

    2016-01-01

    In this review we consider first order gravity in four dimensions. In particular, we focus our attention in formulations where the fundamental variables are a tetrad $e_a^I$ and a SO(3,1) connection ${\\omega_{aI}}^J$. We study the most general action principle compatible with diffeomorphism invariance. This implies, in particular, considering besides the standard Einstein-Hilbert-Palatini term, other terms that either do not change the equations of motion, or are topological in nature. Having a well defined action principle sometimes involves the need for additional boundary terms, whose detailed form may depend on the particular boundary conditions at hand. In this work, we consider spacetimes that include a boundary at infinity, satisfying asymptotically flat boundary conditions and/or an internal boundary satisfying isolated horizons boundary conditions. We focus on the covariant Hamiltonian formalism where the phase space $\\Gamma$ is given by solutions to the equations of motion. For each of the possible ...

  20. 76 FR 174 - NIJ Draft Metal Detector Standards for Public Safety

    2011-01-03

    ... of Justice Programs NIJ Draft Metal Detector Standards for Public Safety AGENCY: National Institute of Justice. ACTION: Notice and request for comments on the Draft Metal Detector Standards for Public... the following draft standards for metal detectors: 1. Walk-through Metal Detector Standard for...

  1. 75 FR 35508 - Draft Regulatory Guide: Issuance, Availability

    2010-06-22

    ... COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1249, ``Criteria for Use of Computers... CFR Part 73, ``Physical Protection of Plants and Materials,'' regarding the security of digital...

  2. 75 FR 13599 - Draft Regulatory Guide: Issuance, Availability

    2010-03-22

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Draft Regulatory Guide, DG-8040, ``Health Physics Surveys During Enriched Uranium-235 Processing and...

  3. 75 FR 57776 - Clean Water Act Section 303(d): Notice for the Public Review of the Draft Total Maximum Daily...

    2010-09-22

    ... and actions that together ensure that pollution controls needed to restore Bay water quality are.... Thursday, October 7, 2010: VA Watershed meeting from 6 to 8 p.m. at the Crowne Plaza Hampton Marina Hotel... and other pollution controls required by the CWA are not stringent enough to attain or maintain...

  4. Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 124: Storage Tanks, Nevada Test Site, Nevada (Draft), Revision 0

    Alfred Wickline

    2007-04-01

    This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses closure for Corrective Action Unit (CAU) 124, Areas 8, 15, and 16 Storage Tanks, identified in the Federal Facility Agreement and Consent Order. Corrective Action Unit 124 consists of five Corrective Action Sites (CASs) located in Areas 8, 15, and 16 of the Nevada Test Site as follows: • 08-02-01, Underground Storage Tank • 15-02-01, Irrigation Piping • 16-02-03, Underground Storage Tank • 16-02-04, Fuel Oil Piping • 16-99-04, Fuel Line (Buried) and UST This plan provides the methodology of field activities necessary to gather information to close each CAS. There is sufficient information and process knowledge from historical documentation and investigations of similar sites regarding the expected nature and extent of potential contaminants to recommend closure of CAU 124 using the SAFER process.

  5. A review on alcohol: from the central action mechanism to chemical dependency

    João Victor Vezali Costardi

    2015-08-01

    Full Text Available SummaryIntroduction:alcohol is a psychotropic depressant of the central nervous system (CNS that promotes simultaneous changes in several neuronal pathways, exerting a profound neurological impact that leads to various behavioral and biological alterations.Objectives:to describe the effects of alcohol on the CNS, identifying the signaling pathways that are modified and the biological effects resulting from its consumption.Methods:a literature review was conducted and articles published in different languages over the last 15 years were retrieved.Results:the studies reviewed describe the direct effect of alcohol on several neurotransmitter receptors (gamma-aminobutyric acid [GABA], glutamate, endocannabinoids AEA and 2-AG, among others, the indirect effect of alcohol on the limbic and opioid systems, and the effect on calcium and potassium channels and on proteins regulated by GABA in the hippocampus.Discussion and conclusion:the multiple actions of alcohol on the CNS result in a general effect of psychomotor depression, difficulties in information storage and logical reasoning and motor incoordination, in addition to stimulating the reward system, a fact that may explain the development of addiction. Knowledge on the neuronal signaling pathways that are altered by alcohol allows the identification of effectors which could reduce its central action, thus, offering new therapeutic perspectives for the rehabilitation of alcohol addicts.

  6. Treatments and technologies in the rehabilitation of apraxia and action disorganisation syndrome: A review

    Worthington, Andrew

    2016-01-01

    BACKGROUND: Apraxia and Action Disorganisation Syndrome are characterised by an inability to use tools and carry out ordered sequences of movements in the absence of motor or sensory impairment. To date treatment for these complex but debilitating conditions has received little attention. OBJECTIVES: To provide an overview of apraxia and action disorganisation syndrome and its treatment, providing a state of the art summary for practitioners including likely future therapeutic directions. METHOD: Review of apraxia literature and treatment studies collated from internet searches involving MEDLINE, PubMed, PyscINFO and Google Scholar as well as the author’s own catalogue. RESULTS: Evidence for current restitution and compensatory approaches is critically reviewed, with limited evidence to date in support of either method. Strategy training is the most promising intervention type with no support for sensory and exploratory interventions, practice effects only for direct task-specific training, and modest support for gestural training. CONCLUSIONS: Larger controlled studies are needed but evidence is sufficient to indicate certain approaches over others. Advances in assistive technology have not translated into mainstream therapy but future interventions are likely to require a model-based approach which embraces current technologies in order to provide a more accessible, effective and cost-efficient approach to rehabilitation. PMID:27314872

  7. Exploring the relationship between faculty, students, and the Social and Behavioral Ethics Review Committee through action research.

    Griebling, Susan; Zayas, Vilma Reyes; Borders, Christy; Moore, Elizabeth; Sokol, Ashley; Brydon-Miller, Mary; Gerlach, Julie; Norman, Claudia

    2009-06-01

    STUDENT RESEARCHERS USED ACTION research both to study the relationship between university researchers and the ethics committee, and also to explore the ethics committee's approach to protocols involving action research and other qualitative methods. We review the existing literature on relationships between university faculty and their ethics committees and briefly discuss the basic tenets of action research. We then describe our research process and the specific recommendations that resulted from this work. Finally, we consider the ways in which action research can be used to better understand and address institutional problems through effective collaboration and dialogue. PMID:19480589

  8. The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research

    Hui Wang

    2014-01-01

    Full Text Available Rhizoma Coptidis (Huang Lian in Chinese pinyin is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions.

  9. Actions, topological terms and boundaries in first-order gravity: A review

    Corichi, Alejandro; Rubalcava-García, Irais; Vukašinac, Tatjana

    2016-03-01

    In this review, we consider first-order gravity in four dimensions. In particular, we focus our attention in formulations where the fundamental variables are a tetrad eaI and a SO(3, 1) connection ωaIJ. We study the most general action principle compatible with diffeomorphism invariance. This implies, in particular, considering besides the standard Einstein-Hilbert-Palatini term, other terms that either do not change the equations of motion, or are topological in nature. Having a well defined action principle sometimes involves the need for additional boundary terms, whose detailed form may depend on the particular boundary conditions at hand. In this work, we consider spacetimes that include a boundary at infinity, satisfying asymptotically flat boundary conditions and/or an internal boundary satisfying isolated horizons boundary conditions. We focus on the covariant Hamiltonian formalism where the phase space Γ is given by solutions to the equations of motion. For each of the possible terms contributing to the action, we consider the well-posedness of the action, its finiteness, the contribution to the symplectic structure, and the Hamiltonian and Noether charges. For the chosen boundary conditions, standard boundary terms warrant a well posed theory. Furthermore, the boundary and topological terms do not contribute to the symplectic structure, nor the Hamiltonian conserved charges. The Noether conserved charges, on the other hand, do depend on such additional terms. The aim of this manuscript is to present a comprehensive and self-contained treatment of the subject, so the style is somewhat pedagogical. Furthermore, along the way, we point out and clarify some issues that have not been clearly understood in the literature.

  10. Developing Low Carbon Transport Policies in Peru - Draft Transport NAMA

    Ramirez Brinez, C. P.; Tyler, N.

    2012-01-01

    The report is an initial draft of a Transport NAMA for Peru. NAMA stands for Nationally Appropriate Mitigation Actions and are a relatively new initiative from the UNFCCC to tackle climate change. The report covers

  11. Radioactive waste isolation in salt: Peer review of the Office of Nuclear Waste Isolation's draft report on an issues hierarchy and data needs for site characterization

    Harrison, W.; Fenster, D.F.; Ditmars, J.D.; Paddock, R.A.; Rote, D.M.; Hambley, D.F.; Seitz, M.G.; Hull, A.B.

    1986-12-01

    At the request of the Salt Repository Project (SRPO), Argonne National Laboratory conducted an independent peer review of a report by the Battelle Office of Nuclear Waste Isolation entitled ''Salt Repository Project Issues Hierarchy and Data Needs for Site Characterization (Draft).'' This report provided a logical structure for evaluating the outstanding questions (issues) related to selection and licensing of a site as a high-level waste repository. It also provided a first estimate of the information and data necessary to answer or resolve those questions. As such, this report is the first step in developing a strategy for site characterization. Microfiche copies of ''Draft Issues Hierarchy, Resolution Strategy, and Information Needs for Site Characterization and Environmental/Socioeconomic Evaluation - July, 1986'' and ''Issues Hierarchy and Data Needs for Site Characterization - February, 1985'' are included in the back pocket of this report.

  12. ERG review of ''draft test plan for in situ testing in an exploratory shaft in salt - March 1985''

    The Engineering Review Group (ERG) was established by the Office of Nuclear Waste Isolation (ONWI) to help evaluate engineering-related issues in the US Department of Energy's nuclear waste repository program. The May 1985 meeting of the ERG reviewed the proposed program which constitutes part of the overall effort to determine site suitability, provide data for repository design and performance assessment, and prepare licensing documentation for radioactive waste disposal in salt. This report documents the ERG's comments and recommendations on these subjects and the ONWI response, prepared by Golder Associates, Inc., to the specific points raised by the ERG

  13. 78 FR 15012 - Request for Nominations of Experts for a Science Advisory Board Panel To Review EPA's Draft...

    2013-03-08

    ... men of all racial and ethnic groups. The EPA SAB Staff Office will acknowledge receipt of nominations... a balanced review panel includes candidates who possess the necessary domains of knowledge, the... expertise, knowledge, and experience (primary factors); (b) availability and willingness to serve;...

  14. Development of a Relative Potency Factor (Rpf) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of polycyclic aromatic hydrocarbon (PAH) mixtures that when finalized will appear on the Integrated Risk Information System (IRIS) database. ...

  15. 75 FR 1617 - Draft Toxicological Review of Methanol: In Support of the Summary Information in the Integrated...

    2010-01-12

    ... Office of Research and Development (ORD). The public comment period and the EPA Science Advisory Board... peer review under applicable information quality guidelines. This document has not been formally... separate processes that provide opportunities for all interested parties to comment on the document....

  16. Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications.

    Chen, Chunqiu; Yu, Zhen; Li, Yongyu; Fichna, Jakub; Storr, Martin

    2014-01-01

    Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp. and Berberis sp. In traditional medicine, extracts of berberine are used in the treatment of diarrhea of different origins. Recent studies have shown that berberine and its derivatives have significant biological effects on gastrointestinal (GI) and other functions and may become therapeutics for the treatment of diarrhea, gastroenteritis, diabetes, hyperlipidemia, cardiovascular diseases and inflammatory conditions. This paper summarizes the current knowledge on the actions of berberine in the GI tract. Binding and target sites, activated intracellular pathways, as well as the absorption and metabolism of berberine are discussed. Effects that may be useful in future clinical treatment, like antidiarrheal, anti-inflammatory and antitumor effects are critically reviewed and potential clinical applications are presented in detail. PMID:25183302

  17. A review of ideomotor approaches to perception, cognition, action, and language: advancing a cultural recycling hypothesis.

    Badets, Arnaud; Koch, Iring; Philipp, Andrea M

    2016-01-01

    The term "cultural recycling" derives from the neuronal recycling hypothesis, which suggests that representations of cultural inventions like written words, Arabic numbers, or tools can occupy brain areas dedicated to other functions. In the present selective review article, we propose a recycling hypothesis for the ideomotor mechanism. The ideomotor approach assumes that motor actions are controlled by the anticipation of the expected perceptual consequences that they aim to generate in the environment. Arguably, such action-perception mechanisms contribute to motor behaviour for human and non-human animals since millions of years. However, recent empirical studies suggest that the ideomotor mechanism can also contribute to word processing, number representation, and arithmetic. For instance, it has been shown that the anticipatory simulation of abstract semantics, like the numerical quantitative value of three items can prime processing of the associated Arabic number "3". Arabic numbers, words, or tools represent cultural inventions, so that, from a theoretical perspective, we suggest an ideomotor recycling hypothesis for the interaction with such artefacts. In this view, the ideomotor mechanism spreads its influence to other functions beyond motor control, and is recycled to flexibly adapt different human behaviours towards dealing with more abstract concepts. PMID:25535019

  18. Board-invited review: Estrogen and progesterone signaling: genomic and nongenomic actions in domestic ruminants.

    Stormshak, F; Bishop, C V

    2008-02-01

    Progesterone and estrogens play key roles in regulating various physiological phenomena related to normal growth, development, and reproduction of domestic animals. This review focuses on the mechanisms by which progesterone and estrogens regulate the reproductive processes in these animals. The majority of research on the actions of progesterone and estrogens on the reproductive systems of cattle, sheep, and pigs has been genomic in nature and represents attempts to better understand how these steroids regulate gene expression. Results of recent research suggest that progesterone and estrogens can alter target cell responses nongenomically via membrane receptors. The characteristics of membrane receptors for progesterone and estrogen in various cell types are described and the intracellular signal pathways defined. Estrogens acting via membrane receptors can suppress LH secretion by gonadotropes and stimulate rapid increases in uterine blood flow. Progesterone acting via a membrane receptor has been shown to inhibit binding of oxytocin to oxytocin receptors in isolated endometrial plasma membranes and stimulate capacitation of spermatozoa. Results of research suggest that progesterone and estrogens can act nongenomically to alter target cell responses in domestic animals. The biological implications of this mode of action in these animals are discussed. PMID:17965328

  19. Herbal Remedies for Coccidiosis Control: A Review of Plants, Compounds, and Anticoccidial Actions

    Thangarasu Muthamilselvan

    2016-01-01

    Full Text Available Coccidiosis is the bane of the poultry industry causing considerable economic loss. Eimeria species are known as protozoan parasites to cause morbidity and death in poultry. In addition to anticoccidial chemicals and vaccines, natural products are emerging as an alternative and complementary way to control avian coccidiosis. In this review, we update recent advances in the use of anticoccidial phytoextracts and phytocompounds, which cover 32 plants and 40 phytocompounds, following a database search in PubMed, Web of Science, and Google Scholar. Four plant products commercially available for coccidiosis are included and discussed. We also highlight the chemical and biological properties of the plants and compounds as related to coccidiosis control. Emphasis is placed on the modes of action of the anticoccidial plants and compounds such as interference with the life cycle of Eimeria, regulation of host immunity to Eimeria, growth regulation of gut bacteria, and/or multiple mechanisms. Biological actions, mechanisms, and prophylactic/therapeutic potential of the compounds and extracts of plant origin in coccidiosis are summarized and discussed.

  20. Viral inactivation in hemotherapy: systematic review on inactivators with action on nucleic acids

    Patricia Marial Sobral

    2012-01-01

    Full Text Available The aim of this study was to conduct a systematic review on the photoinactivators used in hemotherapy, with action on viral genomes. The SciELO, Science Direct, PubMed and Lilacs databases were searched for articles. The inclusion criterion was that these should be articles on inactivators with action on genetic material that had been published between 2000 and 2010. The key words used in identifying such articles were "hemovigilance", "viral inactivation", "photodynamics", "chemoprevention" and "transfusion safety". Twenty-four articles on viral photoinactivation were found with the main photoinactivators covered being: methylene blue, amotosalen HCl, S-303 frangible anchor linker effector (FRALE, riboflavin and inactin. The results showed that methylene blue has currently been studied least, because it diminishes coagulation factors and fibrinogen. Riboflavin has been studied most because it is a photoinactivator of endogenous origin and has few collateral effects. Amotosalen HCl is effective for platelets and is also used on plasma, but may cause changes both to plasma and to platelets, although these are not significant for hemostasis. S-303 FRALE may lead to neoantigens in erythrocytes and is less indicated for red-cell treatment; in such cases, PEN 110 is recommended. Thus, none of the methods for pathogen reduction is effective for all classes of agents and for all blood components, but despite the high cost, these photoinactivators may diminish the risk of blood-transmitted diseases.

  1. Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review

    F. Bafort

    2014-01-01

    Full Text Available Lactoperoxidase is a member of the family of the mammalian heme peroxidases which have a broad spectrum of activity. Their best known effect is their antimicrobial activity that arouses much interest in in vivo and in vitro applications. In this context, the proper use of lactoperoxidase needs a good understanding of its mode of action, of the factors that favor or limit its activity, and of the features and properties of the active molecules. The first part of this review describes briefly the classification of mammalian peroxidases and their role in the human immune system and in host cell damage. The second part summarizes present knowledge on the mode of action of lactoperoxidase, with special focus on the characteristics to be taken into account for in vitro or in vivo antimicrobial use. The last part looks upon the characteristics of the active molecule produced by lactoperoxidase in the presence of thiocyanate and/or iodide with implication(s on its antimicrobial activity.

  2. 78 FR 36767 - Red River Hydro LLC; Notice of Availability of Draft Environmental Assessment

    2013-06-19

    ..., 52 FR 47897), the Office of Energy Projects has reviewed Red River Hydro LLC's application for an... Energy Regulatory Commission Red River Hydro LLC; Notice of Availability of Draft Environmental... prepared a draft environmental assessment (draft EA). The project would be located on the Red River...

  3. The Composition and Biologic Actions of Mineral Trioxide Aggregate: A Review

    Toptancı İR et al.

    2013-06-01

    Full Text Available Aim: Mineral Trioxide Aggregate (MTA is widely used in clinical application such as pulp capping, perforation repair, root-end sealing, canal filling at internal and external root resorption and pulpotomies in primary and permanent teeth. In endodontic field when using a material such as MTA the interaction between material and periapical tissue is so important for healing and life time of endodontic therapy. Although it is sealing ability, the interaction with cells or tissues and their replay to this material play major role for endodontic success. Methods: Literature review was performed using electronic and hand-searching methods for the clinical applications, experimental studies and cellular studies of MTA between 2000 and 2010. Results: MTA is a bioactive material when using vital pulpotomies, apical barrier formation for necrotic pulps and open apices. Numerous study and case reports show MTA is more effective material than other materials in these cases. Many studies have shown the effects of MTA on cementoblasts and odontoblasts. Conclusion: This review shows its composition, biologic action when used different endodontic procedure and interaction between cell and tissues.

  4. Development of a mental health action checklist for improving workplace environment as means of job stress prevention.

    Yoshikawa, Toru; Kawakami, Norito; Kogi, Kazutaka; Tsutsumi, Akizumi; Shimazu, Miyuki; Nagami, Makiko; Shimazu, Akihito

    2007-07-01

    An action checklist for improving the workplace environment by means of enhancing mental health of workers (Mental Health Action Check List: MHACL) was developed. The use of the checklist for primary prevention was examined. MHACL was developed through three steps: (1) Review of related references and collection of improvement examples for designing a draft MHACL; (2) pilot application of the draft at industrial workplaces and trials at workshops of occupational health staff; and (3) proposing a new MHACL for general use in industry. Workplace improvement actions related to mental health were listed in eight technical areas. From 84 workplaces in Japan, 201 such actions were collected. Typical improvement action phrases were extracted based on these examples, and a draft MHACL containing 40 generally applicable actions were prepared. This draft was applied to selected workplaces for its use as a tool for group discussion. Then, the utility of the checklist was discussed by 105 occupational health staff working in public service offices. The workshop suggested modifications of the draft MHACL including improved check items and usage procedures and the need to use easy-to-understand actions. The final version of the MHACL comprised 30 items in six technical areas: A) sharing work planning, B) work time and organization, C) ergonomic work methods, D) workplace environment, E) mutual support in the workplace, and F) preparedness and care. A new action checklist was proposed for use as a means of changing existing workplace environments and proposing practical actions for improving it. The checklist was confirmed to be useful for organizing workplace-level discussion for identifying immediate improvements at the workplace. The checklist is expected to be widely applied for promoting primary prevention measures in terms of better mental health. PMID:17721060

  5. 76 FR 55391 - Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of...

    2011-09-07

    ... announced on August 17, 2011 (76 FR 51034). Information about rescheduling the release of the draft... HUMAN SERVICES Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental... (NIEHS), National Institutes of Health. ACTION: Notice of postponement of draft NTP monograph and...

  6. 76 FR 9590 - Fisheries and Habitat Conservation and Migratory Birds Programs; Draft Land-Based Wind Energy...

    2011-02-18

    ...; Draft Land-Based Wind Energy Guidelines AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of... comment of draft Wind Energy Guidelines (Guidelines). These draft Guidelines are intended to supersede the... intended to respond to accelerated development of land-based, wind energy generation projects in the...

  7. Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review.

    du Jardin, Kristian Gaarn; Müller, Heidi Kaastrup; Elfving, Betina; Dale, Elena; Wegener, Gregers; Sanchez, Connie

    2016-11-01

    A single i.v. infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor antagonist, may alleviate depressive symptoms within hours of administration in treatment resistant depressed patients, and the antidepressant effect may last for several weeks. These unique therapeutic properties have prompted researchers to explore the mechanisms mediating the antidepressant effects of ketamine, but despite many efforts, no consensus on its antidepressant mechanism of action has been reached. Recent preclinical reports have associated the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) with the antidepressant-like action of ketamine. Here, we review the current evidence for a serotonergic role in ketamine's antidepressant effects. The pharmacological profile of ketamine may include equipotent activity on several non-NMDA targets, and the current hypotheses for the mechanisms responsible for ketamine's antidepressant activity do not appear to preclude the possibility that non-glutamate neurotransmitters are involved in the antidepressant effects. At multiple levels, the serotonergic and glutamatergic systems interact, and such crosstalk could support the notion that changes in serotonergic neurotransmission may impact ketamine's antidepressant potential. In line with these prospects, ketamine may increase 5-HT levels in the prefrontal cortex of rats, plausibly via hippocampal NMDA receptor inhibition and activation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. In addition, a number of preclinical studies suggest that the antidepressant-like effects of ketamine may depend on endogenous activation of 5-HT receptors. Recent imaging and behavioral data predominantly support a role for 5-HT1A or 5-HT1B receptors, but the full range of 5-HT receptors has currently not been systematically investigated in this context. Furthermore, the nature of any 5-HT dependent mechanism in ketamine's antidepressant effect is currently not

  8. A Review of Training Methods and Instructional Techniques: Implications for Behavioral Skills Training in U.S. Astronauts (DRAFT)

    Hysong, Sylvia J.; Galarza, Laura; Holland, Albert W.

    2007-01-01

    Long-duration space missions (LDM) place unique physical, environmental and psychological demands on crewmembers that directly affect their ability to live and work in space. A growing body of research on crews working for extended periods in isolated, confined environments reveals the existence of psychological and performance problems in varying degrees of magnitude. The research has also demonstrated that although the environment plays a cathartic role, many of these problems are due to interpersonal frictions (Wood, Lugg, Hysong, & Harm, 1999), and affect each individual differently. Consequently, crewmembers often turn to maladaptive behaviors as coping mechanisms, resulting in decreased productivity and psychological discomfort. From this body of research, critical skills have been identified that can help a crewmember better navigate the psychological challenges of long duration space flight. Although most people lack several of these skills, most of them can be learned; thus, a training program can be designed to teach crewmembers effective leadership, teamwork, and self-care strategies that will help minimize the emergence of maladaptive behaviors. Thus, it is the purpose of this report is twofold: 1) To review the training literature to help determine the optimal instructional methods to use in delivering psychological skill training to the U.S. Astronaut Expedition Corps, and 2) To detail the structure and content of the proposed Astronaut Expedition Corps Psychological Training Program.

  9. Review of Indigenous Health Curriculum in Nutrition and Dietetics at One Australian University: An Action Research Study

    Wilson, Annabelle M.; Mehta, Kaye; Miller, Jacqueline; Yaxley, Alison; Thomas, Jolene; Jackson, Kathryn; Wray, Amanda; Miller, Michelle D.

    2015-01-01

    This article describes a review undertaken in 2012-2013 by Nutrition and Dietetics, Flinders University, to assess the Indigenous health curriculum of the Bachelor of Nutrition and Dietetics (BND) and Masters of Nutrition and Dietetics (MND). An action research framework was used to guide and inform inquiry. This involved four stages, each of…

  10. Action Research, Assessment, and Institutional Review Boards (IRB): Conflicting Demands or Productive Tension for the Academic Librarian?

    Farrell, Robert

    2014-01-01

    This article puts forward an "assessment/action research/publication" cycle that integrates aspects of the assessment, research, and Institutional Review Board (IRB) processes to provide academic librarians with a systematic approach for balancing competing workplace demands and give library managers a roadmap for creating a…

  11. Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers

    T. Dörner; N. Kinnman; P.P. Tak

    2010-01-01

    B cell-depletion therapy, particularly using anti-CD20 treatment, has provided proof of concept that targeting B cells and the humoral response may result in clinical improvements in immune-mediated inflammatory disease. In this review, the mechanisms of action of B cell-targeting drugs are investig

  12. Insights into Attempts at Using Action Research in a Collaborative Work in a Policy Review Exercise in Botswana

    Koosimile, Anthony Tsatsing

    2011-01-01

    In this paper I embrace the thinking that writing on one's experiences in the use of qualitative educational research strategies and principles could potentially contribute to furthering knowledge in the field. In adopting an action research framework to guide collaborative work in a policy review exercise in Botswana, I found that collaborative…

  13. IAEA OSART/EXPERT follow-up review mission completes assessment of actions taken by Paks Nuclear Power Plant

    On 28 February 2004 the IAEA completed its follow-up review mission to assess the actions taken by Paks nuclear power plant (NPP) in response to the Agency's recommendations and suggestions made during the 2001 Operational Safety Review Team (OSART) mission and the 2003 Expert mission that investigated the fuel cleaning incident at the Paks NPP in Hungary. The mission was requested by the Hungarian Government to provide an independent assessment of the actions taken by Paks NPP. The IAEA team determined that the actions taken by Paks have resulted in tangible progress and concluded that all issues were either fully resolved or progressing satisfactorily. In a press conference, the team's conclusions in five areas were highlighted: management, Regulatory Oversight/Interface, operations and maintenance, including operating experience, radiation protection, emergency planning and preparedness, and transparency

  14. Les impacts de la révision collaborative étayée : une recherche-action en didactique de la production écrite en français langue étrangère.

    Do, Thi Bich Thuy

    2011-01-01

    This action-research aims to measure the effects of a trained peer review experiment in L2 writing instruction. A classroom-based study on peer review training was conducted during one semester with 22 Vietnamese students in a writing class. In the experimental group, the drafts were revised by pair with a peer review checklist questions, then rewritten and corrected by the teacher. In the control group, the drafts were written once and corrected by the teacher. Text and feedbacks corpus, pai...

  15. INHIBITION OF THE SODIUM-IODIDE SYMPORTER BY PERCHLORATE: AN EVALUATION OF LIFESTAGE SENSITIVITY USING PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELING (EXTERNAL REVIEW DRAFT)

    EPA first released this document in draft form as supporting material for the Preliminary Regulatory Determination on Perchlorate (FR Notice) in October 2008. The document has since been revised. The final report is available in response to comments from independent external pee...

  16. Human-factors control-room-design review draft audit report: Detroit Edison Company, Enrico Fermi Atomic Power Plant--Unit 2

    A human factors audit of the Fermi-2 control room was conducted April 27 through May 1, 1981. This report contains the audit team findings, organized according to the draft NUREG-0700 guidelines sections. The discrepancies identified during the audit are categorized according to their severity and the required schedule for their resolution

  17. 78 FR 78366 - Draft Generic Drug User Fee Act Information Technology Plan; Availability for Comment

    2013-12-26

    ...-based environment that enhances the regulatory review process for human pharmaceuticals. DATES: Submit... approvals, drug supply chain, and other topics related to human pharmaceuticals. The draft GDUFA IT...

  18. Thought-action fusion: review of the literature and future directions.

    Berle, David; Starcevic, Vladan

    2005-05-01

    Thought-action fusion (TAF) is the tendency for individuals to assume that certain thoughts either imply the immorality of their character or increase the likelihood of catastrophic events. The burgeoning literature on TAF is reviewed. It is not clear whether TAF refers to a specific appraisal style, a more enduring belief, or a combination of both. Inconsistent definitions of magical thinking have hindered better understanding of the relationship between TAF and magical thinking. Much work remains to be done to improve assessment and measurement of TAF. TAF is associated with tendencies towards obsessive-compulsive disorder (OCD) and may contribute to its symptoms. However, the literature investigating TAF and other variables implicated in OCD remains inconclusive. It is suggested that TAF is not specific to OCD, but also prevalent in other anxiety disorders. TAF appears to be moderately related to depressive symptoms and a similar bias may contribute to preoccupations in eating disorders. TAF is also associated with the presence of psychological disorders in children and adolescents. Educational and cognitive therapy approaches to reduce TAF and consequent symptoms are discussed, and suggestions for further research made. PMID:15792850

  19. Categorizing health-related cues to action: using Yelp reviews of restaurants in Hawaii

    Ariyasriwatana, W.; Buente, W.; Oshiro, M.; Streveler, D.

    2014-10-01

    Yelp, a social media site, undeniably has an influence on consumers' food choice in spite of its ability to reflect consumers' real voice being criticized. Since unhealthy food choices contribute to health problems, such as obesity and malnourishment, we attempted to examine these problems by better understanding consumers through health-related cues to action-a construct from the Health Belief Model (HBM)- on Yelp Honolulu's restaurant reviews. Our research revealed 13 main categories: Ingredient, Type of food, Taste, Lifestyle, Cooking, Option, Price, Portion, Well-being, Nutrition, Hygiene, Emotional attachment and indulgence, and Feeling. We argue that these categories may ultimately lead consumers to make healthier food choices. In search of the most appealing way to communicate with the target group, underlying concepts that derived from these categories can be tested. Marketers in food industry (or public health policy-makers) can craft their strategies for healthy food brands/products (or healthy eating scheme) based on the concept test research. Moreover, Yelp can apply these insights in the development of their algorithm and filter system in order to help consumers find healthy food if they wish to do so. Restaurants can also improve their strategy, menu, and communication execution to meet the growing demands of health conscious consumers.

  20. Basic Drafting: Book One.

    Davis, Ronald; And Others

    The first of a two-book course in drafting, this manual consists of 13 topics in the following units: introduction to drafting, general safety, basic tools and lines, major equipment, applying for a job, media, lettering, reproduction, drawing sheet layout, architect's scale usage, civil engineer's scale usage, mechanical engineer's scale usage,…

  1. Legal contract drafting support

    Pace, Gordon; Duca, Edward

    2012-01-01

    The notary drafts the contract on her computer – fixing a highlighted typo, ignoring the complex grammar warning. More worrying is the clause highlighted with an explanation of how it conflicts with another contract her client has signed. http://www.um.edu.mt/think/legal-contract-drafting-support/

  2. Review Essay: Von lokaler Praxis zu öffentlichem Wissen: Action Research als wissenschaftlicher Forschungsansatz

    Martí, Joel

    2008-01-01

    In den letzten Jahren hat Action Research schrittweise Eingang ins akademische Denken gefunden und auch Buchveröffentlichungen nach sich gezogen wie das hier besprochene The Action Research Dissertation, das im Besonderen auf Dissertationsprojekte (Forschungsprozess und Dokumentation) zielt. Neben eher technischen Aspekten (Kriterien und "Werkzeuge" für Action-Research-Dissertationen) werden in dem Buch einige Themen behandelt, die von essenzieller Bedeutung für universitäre Projekte sind, be...

  3. Drafting method of electricity and electron design

    This book concentrates on drafting of electricity and electron design. It deals with The meaning of electricity and electron drafting JIS standard regulation the types of drafting and line and letter, basics drafting with projection drafting method, plan projection and development elevation, Drafting method of shop drawing, practical method of design and drafting, Design and drafting of technic and illustration, Connection diagram, Drafting of wiring diagram for light and illumination, Drafting of development connection diagram for sequence control, Drafting of logic circuit sign of flow chart and manual, drafting for a electron circuit diagram and Drawing of PC board.

  4. Career Directions for Drafting CAD Technicians.

    Moore, Pam

    2002-01-01

    Provides information careers for drafting/computer-assisted drafting technicians, including salaries, responsibilities, employment outlook, working conditions, skills needed, and career advancement opportunities. Lists professional drafting organizations. (JOW)

  5. The action of corticosteroids on orthodontic tooth movement: a literature review

    Luegya Amorim Henriques Knop

    2012-12-01

    Full Text Available INTRODUCTION: Tooth movement is initially characterized by an acute sterile inflammation, followed by sequential multiple reactions in the periodontal ligament in response to biomechanical forces. Pharmacological agents such as corticosteroids may affect the course of orthodontic movement. Scientific studies show antagonistic actions of these drugs on bone resorption during tooth movement. OBJECTIVE: To review the literature about the effect of corticosteroids on orthodontic tooth movement. CONCLUSION: Patients should be questioned regarding the use of these drugs in the orthodontic practice and for those who use them, the orthodontic treatment should be differentiated, with longer intervals between visits and periodic X-rays due to the delay in bone formation observed in some scientific studies.INTRODUÇÃO: a movimentação dentária é caracterizada, inicialmente, por uma inflamação aguda estéril, seguida por reações múltiplas sequenciais no ligamento periodontal em resposta às forças biomecânicas. Agentes farmacológicos, como os corticosteroides, podem alterar o curso da movimentação ortodôntica. Os estudos científicos demonstram ações antagonistas dessas drogas sobre a reabsorção óssea durante a movimentação dentária. OBJETIVO: realizar revisão de literatura sobre a ação dos corticosteroides no movimento dentário ortodôntico. CONCLUSÃO: os pacientes devem ser questionados quanto ao uso dessas drogas na clínica ortodôntica e, para aqueles que fazem uso, o tratamento ortodôntico deve ser diferenciado, com intervalos maiores entre as consultas e solicitação periódica de radiografias devido ao atraso na neoformação óssea observado em alguns estudos científicos.

  6. Mechanisms of action of brief alcohol interventions remain largely unknown – A narrative review

    Jacques eGaume

    2014-08-01

    Full Text Available A growing body of evidence has shown efficacy of brief intervention (BI for hazardous and harmful alcohol use in primary health care settings. Evidence for efficacy in other settings, and effectiveness when implemented at larger scale is disappointing. Indeed, BI comprises varying content, and exploring BI content and mechanisms of action may be a promising way to enhance efficacy and effectiveness.We searched Medline and PsychInfo, as well as references of retrieved publications for original research or reviews on active ingredients (or components, or mechanisms of face-to-face BIs (and its subtypes, including brief advice and brief motivational interviewing [BMI] for alcohol. Overall, BI active ingredients have been scarcely investigated, almost only within BMI, and mostly among Emergency Room patients, young adults, and US college students. This body of research has shown that personalized feedback may be an effective component; specific MI techniques showed mixed findings; decisional balance findings tended to suggest a potential detrimental effect; while change plan exercises, advice to reduce or stop drinking, presenting alternative change options, and moderation strategies are promising but need further study. Client change talk is a potential mediator of BMI effects; change in norm perceptions and enhanced discrepancy between current behavior and broader life goals and values have received preliminary support; readiness to change was only partially supported as a mediator; while enhanced awareness of drinking, perceived risks/benefits of alcohol use, alcohol treatment seeking, and self-efficacy were seldom studied and have as yet found no significant support as such.Research is obviously limited and has provided no clear and consistent evidence on the mechanisms of alcohol BI. How BI achieves the effects seen in randomized trials remains mostly unknown and should be investigated to inform the development of more effective interventions.

  7. Economic evidence on identifying clinically actionable findings with whole-genome sequencing: a scoping review.

    Douglas, Michael P; Ladabaum, Uri; Pletcher, Mark J; Marshall, Deborah A; Phillips, Kathryn A

    2016-02-01

    The American College of Medical Genetics and Genomics (ACMG) recommends that mutations in 56 genes for 24 conditions are clinically actionable and should be reported as secondary findings after whole-genome sequencing (WGS). Our aim was to identify published economic evaluations of detecting mutations in these genes among the general population or among targeted/high-risk populations and conditions and identify gaps in knowledge. A targeted PubMed search from 1994 through November 2014 was performed, and we included original, English-language articles reporting cost-effectiveness or a cost-to-utility ratio or net benefits/benefit-cost focused on screening (not treatment) for conditions and genes listed by the ACMG. Articles were screened, classified as targeting a high-risk or general population, and abstracted by two reviewers. General population studies were evaluated for actual cost-effectiveness measures (e.g., incremental cost-effectiveness ratios (ICER)), whereas studies of targeted populations were evaluated for whether at least one scenario proposed was cost-effective (e.g., ICER of ≤$100,000 per life-year or quality-adjusted life-year gained). A total of 607 studies were identified, and 32 relevant studies were included. Identified studies addressed fewer than one-third (7 of 24; 29%) of the ACMG conditions. The cost-effectiveness of screening in the general population was examined for only 2 of 24 conditions (8%). The cost-effectiveness of most genetic findings that the ACMG recommends for return has not been evaluated in economic studies or in the context of screening in the general population. The individual studies do not directly address the cost-effectiveness of WGS. PMID:25996638

  8. Natural cures for type 1 diabetes: a review of phytochemicals, biological actions, and clinical potential.

    Chang, C L T; Chen, Yi-Ching; Chen, Hui-Ming; Yang, Ning-Sun; Yang, Wen-Chin

    2013-01-01

    Autoimmune diseases are the third largest category of illness in the industrialized world, following cardiovascular diseases and cancers. Among them, type 1 diabetes, also named autoimmune diabetes, afflicts 10 million people worldwide. This disease is caused by autoimmunity-mediated destruction of pancreatic β-cells, leading to insulin deficiency, hyperglycemia and complications. Currently, there is no cure for type 1 diabetes. Insulin injection is the only medication; however, it accompanies serious medical complications. Current strategies to cure type 1 diabetes include immunotherapy, replacement therapy, and combination therapy. Despite recent advances in anti-diabetic strategies, no strategy is clinically successful. How to cure type 1 diabetes without undesirable side effects still remains a formidable challenge in drug research and development. Plants provide an extraordinary source of natural medicines for different diseases. Moreover, secondary metabolites of plant origin serve as an invaluable chemical library for drug discovery and current medicinal chemistry in the pharmaceutical industry. Over the past 25 years, 50% of prescription drugs have been developed from natural products and their derivatives. In this article, we review more than 20 plant compounds and extracts reported in the literature to prevent and treat type-1 diabetes. Emphasis is placed on their chemistry and biology in terms of regulation of immune cells and pancreatic β-cells. We summarize recent progress in understanding the biological actions, mechanisms and therapeutic potential of the compounds and extracts of plant origin in type 1 diabetes. New views on phytocompound-based strategies for prevention and treatment of type 1 diabetes are also discussed. PMID:23210779

  9. Evaluations for draft reports on geological disposal

    This report summarizes the results of the technical evaluations on two reports which are named as 'Overview of the Geological Disposal Facility' and Considerable Factors on Selection of Potential Sites for Geological Disposal' drafted by NUMO (Nuclear Waste Management Organization of Japan). The review of each draft report has been referred to committee (held on 9th September, 2002) and working group (held on 1st October, 2002) which were organized in order to confirm a progress of implementation of geological disposal by government. (author)

  10. Impact of safety-related regulatory action on clinical practice : a systematic review

    Piening, S.; Haaijer-Ruskamp, F.M.; de Vries, J.T.; van der Elst, M.E.; de Graeff, P.A.; Straus, S.M.; Mol, P.G.

    2012-01-01

    Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of th

  11. Impact of Safety-Related Regulatory Action on Clinical Practice A Systematic Review

    Piening, Sigrid; Haaijer-Ruskamp, Flora M.; de Vries, Jonie T. N.; van der Elst, Menno E.; de Graeff, Pieter A.; Straus, Sabine M. J. M.; Mol, Peter G. M.

    2012-01-01

    Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of th

  12. Public Review Draft: A Method for Assessing Carbon Stocks, Carbon Sequestration, and Greenhouse-Gas Fluxes in Ecosystems of the United States Under Present Conditions and Future Scenarios

    Bergamaschi, Brian A.; Bernknopf, Richard; Clow, David; Dye, Dennis; Faulkner, Stephen; Forney, William; Gleason, Robert; Hawbaker, Todd; Liu, Jinxun; Liu, Shu-Guang; Prisley, Stephen; Reed, Bradley; Reeves, Matthew; Rollins, Matthew; Sleeter, Benjamin; Sohl, Terry; Stackpoole, Sarah; Stehman, Stephen; Striegl, Rob; Wein, Anne; Zhu, Zhi-Liang

    2010-01-01

    The Energy Independence and Security Act of 2007 (EISA), Section 712, authorizes the U.S. Department of the Interior to develop a methodology and conduct an assessment of the Nation's ecosystems focusing on carbon stocks, carbon sequestration, and emissions of three greenhouse gases (GHGs): carbon dioxide, methane, and nitrous oxide. The major requirements include (1) an assessment of all ecosystems (terrestrial systems, such as forests, croplands, wetlands, shrub and grasslands; and aquatic ecosystems, such as rivers, lakes, and estuaries), (2) an estimation of annual potential capacities of ecosystems to increase carbon sequestration and reduce net GHG emissions in the context of mitigation strategies (including management and restoration activities), and (3) an evaluation of the effects of controlling processes, such as climate change, land use and land cover, and wildlfires. The purpose of this draft methodology for public review is to propose a technical plan to conduct the assessment. Within the methodology, the concepts of ecosystems, carbon pools, and GHG fluxes used for the assessment follow conventional definitions in use by major national and international assessment or inventory efforts. In order to estimate current ecosystem carbon stocks and GHG fluxes and to understand the potential capacity and effects of mitigation strategies, the method will use two time periods for the assessment: 2001 through 2010, which establishes a current ecosystem GHG baseline and will be used to validate the models; and 2011 through 2050, which will be used to assess future potential conditions based on a set of projected scenarios. The scenario framework is constructed using storylines of the Intergovernmental Panel on Climate Change (IPCC) Special Report Emission Scenarios (SRES), along with initial reference land-use and land-cover (LULC) and land-management scenarios. An additional three LULC and land-management mitigation scenarios will be constructed for each

  13. Book Review ~ Action learning: Images and pathways. Author: Robert L. Dilworth and Verna J. Willis

    Reviewed by Patrick J. Fahy

    2003-01-01

    Action learning, as defined in this book, is “a process of reflecting on one’s work and beliefs in the supportive/ confrontational environment of one’s peers for the purpose of gaining new insights and resolving real business and community problems in real time” (p. 11). The claims made for action learning are impressive. Action learning: * Allows participants (who work in groups called sets) to answer the question, “What is an honest man, and what do I need to do to become one?” (p. viii)...

  14. 76 FR 54502 - Energy Northwest, Columbia Generating Station; Notice of Availability of Draft Supplement 47 to...

    2011-09-01

    ... COMMISSION Energy Northwest, Columbia Generating Station; Notice of Availability of Draft Supplement 47 to... Regulatory Commission (NRC) has published a draft plant-specific supplement to the Generic Environmental... renewal) include no action and reasonable alternative energy sources. Any interested party may...

  15. 75 FR 7256 - Denali Commission Fiscal Year 2010 Draft Work Plan

    2010-02-18

    ...). The Denali Commission Act requires that the Commission develop proposed work plans for future spending... Commission Fiscal Year 2010 Draft Work Plan AGENCY: Denali Commission. ACTION: Denali Commission Fiscal Year 2010 Draft Work Plan request for comments. SUMMARY: The Denali Commission (Commission) is...

  16. 75 FR 69649 - Notice of Availability for the Draft Programmatic Environmental Assessment for the Development...

    2010-11-15

    ... comment period begins upon publication of a Notice of Availability (NOA) for the Draft PEA in the Federal..., present, and reasonably foreseeable future actions. Schedule: NOA of the Draft PEA will be published in... a NOA of the FONSI or Notice of Intent (NOI) to prepare an EIS will be published. Dated: November...

  17. 78 FR 68852 - Draft Guidance for Industry on Acrylamide in Foods; Availability

    2013-11-15

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Acrylamide in Foods; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA or we) is announcing the availability of a draft guidance entitled ``Guidance for...

  18. 77 FR 67379 - Draft Guidance for Industry and Food and Drug Administration Staff; Highly Multiplexed...

    2012-11-09

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Devices; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and... pathogen nucleic acids extracted from a single appropriate human specimen or culture. This draft...

  19. A Conceptual Review on Action-Perception Coupling in the Musicians’ Brain: What Is It Good for?

    Giacomo Novembre

    2014-08-01

    Full Text Available Experience with a sensorimotor task, such as practicing a piano piece, leads to strong coupling of sensory (visual or auditory and motor cortices. Here we review behavioural and neurophysiological (M/EEG, TMS and fMRI research exploring this topic using the brain of musicians as a model system. Our review focuses on a recent body of evidence suggesting that this form of coupling might have (at least two cognitive functions. First, it leads to the generation of equivalent predictions (concerning both when and what event is more likely to occur during both perception and production of music. Second, it underpins the common coding of perception and action that supports the integration of the motor output of multiple musicians’ in the context of joint musical tasks. Essentially, training-based coupling of perception and action might scaffold the human ability to represent complex (structured actions and to entrain multiple agents – via reciprocal prediction and adaptation – in the pursuit of shared goals.

  20. May spa therapy be a valid opportunity to treat hand osteoarthritis? A review of clinical trials and mechanisms of action

    Fortunati, Nicola Angelo; Fioravanti, Antonella; Seri, Gina; Cinelli, Simone; Tenti, Sara

    2016-01-01

    Osteoarthritis (OA) is the most common form of arthritis and its current treatment includes non-pharmacological and pharmacological modalities. Spa therapy represents a popular treatment for many rheumatic diseases. The aim of this review was to summarize the currently available information on clinical effects and mechanisms of action of spa therapy in OA of the hand. We conducted a search of the literature to extract articles describing randomized clinical trials (RCTs) in hand OA published in the period 1952-2015. We identified three assessable articles reporting RCTs on spa therapy in hand OA. Data from these clinical trials support a beneficial effect of spa therapy on pain, function and quality of life in hand OA. Spa therapy seems to have a role in the treatment of hand OA. However, additional RCTs are necessary to clarify the mechanisms of action and the effects of the application of thermal treatments.

  1. 77 FR 68790 - Program Comment Issued for Streamlining Section 106 Review for Actions Affecting Post-1945...

    2012-11-16

    ... Concrete and Steel Bridges AGENCY: Advisory Council on Historic Preservation. ACTION: Program Comment... Program Comment applies to effects of undertakings on certain common concrete and steel bridges lacking... post- 1945 concrete and steel bridges would remain unidentified and unprotected in the absence of...

  2. Going to Action? A Literature Review on Educational Proposals in Formal Environmental Education

    Varela-Losada, Mercedes; Vega-Marcote, Pedro; Pérez-Rodríguez, Uxío; Álvarez-Lires, María

    2016-01-01

    The current state of the planet's environmental deterioration calls for formal educational contexts to implement effective environmental proposals which nurture action competence. The aim of this paper is to examine the educational proposals in formal contexts that have been published in the two research journals of greatest impact on…

  3. What predicts intention-behavior discordance? A review of the action control framework

    R.E. Rhodes; G.J. de Bruijn

    2013-01-01

    The physical activity intention-behavior gap is a focus of considerable research. The purpose of this article is to overview contemporary evidence for predictors of this intention-behavior discordance using the action control framework developed in our laboratories. We propose the hypothesis that in

  4. Book Review ~ Action learning: Images and pathways. Author: Robert L. Dilworth and Verna J. Willis

    Reviewed by Patrick J. Fahy

    2003-10-01

    Full Text Available Action learning, as defined in this book, is “a process of reflecting on one’s work and beliefs in the supportive/ confrontational environment of one’s peers for the purpose of gaining new insights and resolving real business and community problems in real time” (p. 11. The claims made for action learning are impressive. Action learning: * Allows participants (who work in groups called sets to answer the question, “What is an honest man, and what do I need to do to become one?” (p. viii. * Is more than learning by doing, action learning “has the potential for putting control of lifelong learning directly in the hands of learners, in ways that alter their perceptions, amplify self-efficacy, and re-connect these individuals to spontaneous curiosity and confidence in the exercise of their own good judgment” (p. xi. * Is a “sleeping giant in the catalogue of individual and organizational change strategies” (p. xi. * Is believed to address the five most important needs facing organizations today: 1 problem-solving; 2 organizational learning; 3 leadership development; 4 professional growth; and 5 career development (p. xiii.

  5. Book Review: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice

    Frederik Holst; Humboldt-Universität zu Berlin

    2014-01-01

    Book Review of the edited compilation: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice; Singapore: NUS Press, ISBN 978-697-5832-67-3, 412 pages

  6. Book Review: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice

    Frederik Holst

    2013-01-01

    Book Review of the edited compilation: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice; Singapore: NUS Press, ISBN 978-697-5832-67-3, 412 pages

  7. MYRRHA Draft-2 Design accomplishments

    One of the main SCK-CEN research facility, namely the Materials Testing Reactor (MTR) BR2, is nowadays in operation for more than 40 years. The need for a safe and economic operation of the European nuclear park for preserving the natural resources, demand the start-up of one or more new MTRs in a very near future. On the other hand the closing of the fuel cycle as well as the development of future energy systems request clearly the use of fast spectrum irradiation facilities. The MYRRHA project started at SCK-CEN in this context, the concept of a new irradiation and testing facility to replace BR2. MYRRHA, being a fast neutron facility, would be a complementary project to the thermal MTR Jules Horowitz Reactor in France. That would give Europe a full research capacity in terms of nuclear research and development for Generation III and IV reactors. At mid-2002, a first pre-design file of MYRRHA (namely the ''MYRRHA Draft - 1'' file with a core nominal power of 30 MWth) has been submitted to an International Technical Guidance Committee (ITGC) for reviewing. No show stopper has been identified in the project. Nevertheless, the ITGC members have recommended: (1) to give more attention to safety studies and iterate to the pre-design before entering the detailed engineering phase; (2) to address some RandD topics to avoid bottlenecks such as fuel pin and assembly development and qualification; (3) to make a decision on the accelerator option (cyclotron or LINAC) and possibly revisit the beam parameters that were already at that moment fixed to 350 MeV*5 mA but mainly derived from the cyclotron technology possibilities. The objective of this effort in the period 2003-2005 was to update and progress the MYRRHA Draft-1 design based on the ITGC evaluation results, the consequences of the safety studies that had to be accomplished on basis of the Draft-1 design and holding the initial objectives of the MYRRHA facility. This resulted at mid-2005 in producing the MYRRHA Draft

  8. 76 FR 43689 - Draft Guidance for Industry and Food and Drug Administration Staff; Mobile Medical Applications...

    2011-07-21

    ... Staff; Mobile Medical Applications; Availability AGENCY: Food and Drug Administration, HHS. ACTION... guidance entitled ``Mobile Medical Applications.'' FDA is issuing this draft guidance to inform... select software applications intended for use on mobile platforms (mobile applications or ``mobile...

  9. 78 FR 57859 - Draft Guidance for Industry on Endocrine Disruption Potential of Drugs: Nonclinical Evaluation...

    2013-09-20

    ... Potential of Drugs: Nonclinical Evaluation; Availability AGENCY: Food and Drug Administration, HHS. ACTION... guidance for industry entitled ``Endocrine Disruption Potential of Drugs: Nonclinical Evaluation.'' This... determine the potential for a drug to disrupt the endocrine system. This draft guidance also...

  10. 76 FR 50740 - Draft Guidance for Industry and Food and Drug Administration Staff; Procedures for Handling...

    2011-08-16

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Procedures for Handling Section 522 Postmarket Surveillance Studies; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...