WorldWideScience

Sample records for action review draft

  1. Pre-conference review of ICPD draft Programme of Action begins.

    1994-05-01

    The Preliminary Draft Document for the International Conference on Population and Development, scheduled for Cairo in September, 1994, aims to provide a shared vision of the needs and demands of population growth and development over the next 20 years, until 2015. Primary concerns focused on the link between population factors and sustainable development, and the need to empowers women and achieve greater gender equity and equality. A holistic approach was recommended in dealing with women's issues such as reproductive health. There are 30 subchapters pertaining to topics such as: poverty alleviation, environmental protection, family diversity, aging, sexuality, AIDS and other sexually transmitted diseases, adolescent health needs, gender relations, male responsibility, urbanization and education. Not only were actions outlined in the draft document, but the requirements of national, regional, and international efforts and resources were delineated. Almost all of the 162 participating countries were in agreement that population must be fully integrated into the development process. About 95% were in agreement on a reproductive health approach that widens considerably the purview of family planning. The approach was not on demographic targets, but on health and education needs of girls and women. Preparatory meetings strengthened chapters on population growth and structure, population development and education, partnerships with nongovernmental groups, child survival and health, and follow-up to the conference. The concerns were not as adequately addressed: unsafe abortion and the health needs of sexually active adolescents. Difficulties with terms such as "safe motherhood," "reproductive health," and "family planning," and several delegations' objections prevented stronger action. PMID:12179006

  2. A national program for energy-efficient mortgages and home energy rating systems: A blueprint for action. Review draft

    1992-03-01

    This Review Draft reports findings and recommendations of the National Collaborative on Home Energy Rating Systems and Mortgage Incentives for Energy Efficiency. The US Department of Energy, in cooperation with the US Department of Housing and Urban Development, formed this National Collaborative as a National Energy Strategy initiative. Participating in the Collaborative were representatives of the primary and secondary mortgage markets, builder and remodeler organizations, real estate and appraiser associations, the home energy rating system industry, utility associations, consumer and public interest groups, state and local government interest groups, and environmental organizations. The Collaborative`s purpose was to develop a voluntary national program encouraging energy efficiency in homes through mortgage incentives linked to home energy ratings.

  3. IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft)

    On May 3, 2013, the Toxicological Review of Methanol (noncancer) (Revised External Review Draft) was posted for public review and comment. Subsequently, the draft Toxicological Review, Appendices, and draft IRIS Summary were reviewed internally by EPA and by other federal agenci...

  4. Energy market review releases draft report

    The Energy Market Review Releases draft report has made recommendations consistent with the Australian Gas Association (AGA)'s submissions in a number of areas. In particular, it has endorsed: 1. the need for an independent review of the gas access regime, to address the deficiencies with current access regulation identified by the Productivity Commission's Review of the National Access Regime; 2. the need for greater upstream gas market competition; 3. the principle that significant regulatory decisions should be subject to clear merits and judicial review; and 4. the need to avoid restrictions on retail energy prices. The report also endorses the need for a 'technology neutral' approach to greenhouse emissions abatement policy. It states that 'many of the current measures employed to reduce greenhouse gas emissions are poorly targeted', and that they 'target technologies or fuel types rather than greenhouse gas abatement.' Additionally, it explicitly recognises the key conclusions of the AGA's recently-released Research Paper, Reducing Greenhouse Emissions from Water Heating: Natural Gas as a Cost-effective Option. The draft report recommends the development of an economy-wide emissions trading system, to achieve a more cost-effective approach to greenhouse abatement

  5. 77 FR 28883 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    2012-05-16

    ... HUMAN SERVICES Centers for Disease Control and Prevention Draft Public Health Action Plan--A National Public Health Action Plan for the Detection, Prevention, and Management of Infertility AGENCY: Centers... requesting public comment on the draft National Public Health Action Plan for the Detection, Prevention,...

  6. 76 FR 11240 - Human Studies Review Board (HSRB); Notification of a Public Teleconference To Review a Draft...

    2011-03-01

    ... AGENCY Human Studies Review Board (HSRB); Notification of a Public Teleconference To Review a Draft Report From HSRB Meeting AGENCY: Environmental Protection Agency (EPA). ACTION: Notice. SUMMARY: The U. S. Environmental Protection Agency (EPA) Office of the Science Advisor (OSA) announces a public teleconference...

  7. IRIS Toxicological Review of Halogenated Platinum Salts and Platinum Compounds (External Review Draft)

    EPA released the draft toxicological review for public comment under the Integrated Risk Information System (IRIS) Program. The original draft assessment (January 2009) has been archived but is available on this web page for the sake of transparency.

  8. 77 FR 66626 - Deepwater Horizon Oil Spill; Draft Early Restoration Plan and Environmental Review

    2012-11-06

    ... Deepwater Horizon Oil Spill; Draft Early Restoration Plan and Environmental Review AGENCY: Interior. ACTION... Addressing Injuries Resulting from the Deepwater Horizon Oil Spill, the Federal and State natural resource... oil spill, which occurred on or about April 20, 2010, in the Gulf of Mexico. The purpose of...

  9. 75 FR 16106 - Draft Toxicological Review of Dichloromethane: In Support of Summary Information on the...

    2010-03-31

    ... science-based human health assessments to support the Agency's regulatory activities. The IRIS database... AGENCY Draft Toxicological Review of Dichloromethane: In Support of Summary Information on the Integrated Risk Information System (IRIS) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice of...

  10. 75 FR 26956 - Draft Toxicological Review of Hexachloroethane: In Support of the Summary Information in the...

    2010-05-13

    ... science-based human health assessments to support the Agency's regulatory activities. The IRIS database... AGENCY Draft Toxicological Review of Hexachloroethane: In Support of the Summary Information in the Integrated Risk Information System (IRIS) AGENCY: Environmental Protection Agency (EPA). ACTION: Notice...

  11. IRIS TOXICOLOGICAL REVIEW OF HEXAVALENT CHROMIUM (INTERAGENCY SCIENCE CONSULTATION DRAFT)

    On Septemeber 30, 2010, the draft Toxicological Review of Hexavalent Chromium and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agenc...

  12. 78 FR 65980 - Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation...

    2013-11-04

    ... AGENCY Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation... have produced draft Climate Change Adaptation Implementation Plans (``Implementation Plans'') that... health and the environment. As EPA articulated in its draft Agency Climate Change Adaptation Plan,...

  13. IRIS Toxicological Review of Urea (Interagency Science Discussion Draft)

    EPA is releasing the draft report, Toxicological Review of Urea,, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. C...

  14. 77 FR 40037 - Notice of the Peer Review Meeting for EPA's Draft Report Entitled An Assessment of Potential...

    2012-07-06

    ... AGENCY Notice of the Peer Review Meeting for EPA's Draft Report Entitled An Assessment of Potential...). ACTION: Notice of external peer review meeting. SUMMARY: The U.S. Environmental Protection Agency (EPA) is announcing that Versar, Inc., an EPA contractor for external peer review, has convened a panel...

  15. Review of Final Draft Core Standards

    R. James Milgram

    2013-04-01

    Full Text Available What follows are my comments on the nal draft of the CCSSI Core Mathematics Standards. There are a number of standards including, but not limited to 1-OA(6, 2-OA(2, 2-NBT(5, 3-OA(7, 3-NBT(2, 4-OA(4, 4-OA(6, 4-NF(1, 4-NF(2, 5-OA(3, 8-G(2, 8-G(4, F-LQE(5, G-SRT(4 that are completely unique to this document, andmost of them seem problematic to me. I have repeatedly asked for references justifying the insertions of these or similar standards in previous drafts, but references have not been provided. Consequently, to my knowledge, there is no real research base for including any of these standards in the document.

  16. Staff supplement to the draft report on human engineering guide to control room evaluation: response to comments, sample checklist, draft systems review guidelines, and evaluation procedures

    This staff supplement to Draft Report NUREG/CR-1580, Human Engineering Guide to Control Room Evaluation, provides staff responses to comments on the draft report and supplemental material not provided in the draft report. The supplemental material includes new draft guidelines for the systems review of nuclear power plant control rooms and sample checklists and corresponding human engineering guidelines

  17. 78 FR 38315 - Registration Review; Draft Human Health and Ecological Risk Assessments; Notice of Availability

    2013-06-26

    ... AGENCY Registration Review; Draft Human Health and Ecological Risk Assessments; Notice of Availability... availability of EPA's draft human health and ecological risk assessments for the registration review of... comprehensive draft risk assessments for each of the subject chemicals and is making them available for...

  18. 78 FR 17201 - Pesticide Chemicals; Registration Review; Draft Human Health and Ecological Risk Assessments...

    2013-03-20

    ... AGENCY Pesticide Chemicals; Registration Review; Draft Human Health and Ecological Risk Assessments... notice announces the availability of EPA's draft human health and ecological risk assessments for the... draft risk assessments for each of the subject chemicals and is making them available for public...

  19. Emergency action levels for light water reactors. Draft report

    United States nuclear power plants are currently preparing revised radiological emergency response plans. As part of these plans, each licensee is establishing plant-specific instrumentation readings, called emergency action levels (EALs), that indicate the presence of a problem and the need to declare one of four classes of emergency as designated by the U.S. Nuclear Regulatory Commission. In this report, the EALs prepared for a pressurized water reactor and a boiling water reactor are assessed to determine whether they meet the requirements of NUREG-0654, Rev. 1 Appendix 1. In addition, five recent nuclear incidents are studied to determine how their outcomes might have been affected by the new emergency response plans. Most of the EALs reviewed were judged adequate. In some cases, alternate EALs or sets of generic EALs are proposed to meet the intent of NUREG-0654 Rev 1 Appendix 1, and the wording of some of the initiating conditions for the four emergency classes is clarified. For three of the five incidents reviewed, the new emergency response plans probably would not have affected the outcome; in one case, the plans would probably have prevented core damage; and any effect on the outcome of the last incident is uncertain

  20. 75 FR 69064 - Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the...

    2010-11-10

    ... AGENCY Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the... period on September 30, 2010 (75 FR 60454) for the external review draft human health assessment titled, ``Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the Integrated...

  1. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Second External Review Draft, 2008)

    EPA has announced that the Second External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise synthesis and evaluation...

  2. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft, 2007)

    EPA has announced that the First External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen – Health Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise synthesis and eva...

  3. An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios (External Review Draft)

    EPA has released an external review draft entitled, An Exploratory Study: Assessment of Modeled Dioxin Exposure in Ceramic Art Studios(External Review Draft). The public comment period and the external peer-review workshop are separate processes that provide opportunities ...

  4. Review of site recommendation process in Draft Environmental Assessments

    In December 1984, the US Department of Energy (DOE) published Draft Environmental Assessments (EAs) on nine potentially acceptable nuclear waste repository sites. Five sites in the states of Mississippi, Nevada, Texas, Utah, and Washington were proposed in the Draft EAs for nomination under the Nuclear Waste Policy Act as suitable for further detailed study (site characterization). The Nevada, Texas, and Washington sites were further proposed for recommendation to the President as preferred for site characterization. This paper reviews the process that DOE used in selecting the three sites proposed for site characterization. The process is consistent with DOE's implementation guidelines for selecting repository sites, and proceeds in three steps. First, the sites are ranked in order of preference for each of twenty technical guidelines based on information in the Draft EAs. The second step combines the individual guideline rankings into postclosure and preclosure guideline group rankings, and, finally, into an overall ranking. In the third step, the sensitivity of the choice of the three preferred sites is examined for a range of guideline weightings

  5. Balancing RIF & Affirmative Action: A Guidebook for Administrators. Draft.

    Ruzicka, Pat; Berard, Barbara, Ed.

    The result of two seminars bringing together educators to discuss the "often conflicting requirements of affirmative action and reductions in force" (RIF), this booklet is intended to provide practical insights and suggestions on meeting affirmative action goals "in situations characterized by staff and program cutbacks." Chapter 1 describes…

  6. 78 FR 56719 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    2013-09-13

    ...: Action Level'' that appeared in the Federal Register of July 15, 2013 (78 FR 42086). The draft guidance...-1639. SUPPLEMENTARY INFORMATION: I. Background In the Federal Register of July 15, 2013 (78 FR 42086... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Arsenic in Apple...

  7. Upstream petroleum industry flaring guide : review draft

    The Alberta requirements and expectations for upstream petroleum flaring are presented. Flaring is associated with a wide range of energy activities including oil and gas well drilling and well completion operations. The guide incorporates the recommendations made to the Alberta Energy and Utilities Board (EUB) in June 1998 by the multi-stakeholder Clean Air Strategic Alliance (CASA) on associated or solution gas flaring. Additional requirements which address flaring issues not covered in the CASA report are also included in this guide. The Guide requires a 15 per cent reduction in solution gas flare volume by the end of year 2000 from the 1996 baseline, and a 25 per cent reduction by the end of 2001. The Guide prescribes new flare performance requirements for all flares, within three years for existing solution gas flares, five years for flares at other existing permanent facilities. It sets personal consultation and public notification requirements for new and existing solution gas batteries, and new sulphur recovery requirements for facilities not covered by existing EUB regulations. The Guide also addresses the question of conflict resolution to deal with flaring concerns, the release of flaring and venting data, the proposed reduction of flare limits, progress towards minimizing requirements for electricity generators using otherwise flared gas, annual reporting to the EUB, and management framework review in 2001

  8. 78 FR 59685 - Registration Review; Draft Human Health and Ecological Risk Assessment; Notice of Availability

    2013-09-27

    ... AGENCY Registration Review; Draft Human Health and Ecological Risk Assessment; Notice of Availability... availability of EPA's draft human health and ecological risk assessments for the registration review for 2... providing advice on ecological risk assessment tools and scientific approaches in developing listed...

  9. 75 FR 60454 - Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the...

    2010-09-30

    ... AGENCY Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the..., ``Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the Integrated Risk..., 2010. The listening session on the draft assessment for hexavalent chromium will be held on November...

  10. 76 FR 20349 - Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the...

    2011-04-12

    ... AGENCY Draft Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the..., ``Toxicological Review of Hexavalent Chromium: In Support of Summary Information on the Integrated Risk... workshop on the draft assessment for Hexavalent Chromium will be held on May 12, 2011, beginning at 8:30...

  11. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft, 2013)

    EPA is announcing the availability of the First External Review Draft of the Integrated Science Assessment for Oxides of Nitrogen – Health Criteria for public comment and independent peer review. This draft document provides EPA’s evaluation and synthesis of the most polic...

  12. 75 FR 29534 - Inorganic Nitrates-Nitrite, Carbon and Carbon Dioxide, and Sulfur Registration Review; Draft...

    2010-05-26

    ... AGENCY Inorganic Nitrates-Nitrite, Carbon and Carbon Dioxide, and Sulfur Registration Review; Draft... draft ecological risk assessment for the registration review of inorganic nitrates - nitrites, carbon... occur for all inorganic nitrates- nitrites, carbon and carbon dioxide uses, as well as gas...

  13. 75 FR 18205 - Notice of Peer Review Meeting for the External Peer Review Drafts of Two Documents on Using...

    2010-04-09

    ... the draft documents (74 FR 41695), and on September 17, 2009 extended the comment period to 60 days (74 FR 47794), thus closing the public comment period on October 16, 2009. The public comment period... AGENCY Notice of Peer Review Meeting for the External Peer Review Drafts of Two Documents on...

  14. Draft emergency action level guidelines for nuclear power plants

    This document is provided for interim use during the initial phases of the NRC effort to promptly improve emergency preparedness at operating nuclear power plants. Changes to the document can be expected as experience is gained in its use and public comments are received. Further, the Commission has initiated a rulemaking procedure, now scheduled for completion in January 1930 in the area of Emergency Planning and Preparedness. Additional requirements are to be expected when rulemaking is completed and some modifications to this document may be necessary. Four classes of Emergency Action Levels are established which replace the classes in Regulatory Guide 1.101, each with associated examples of initiating conditions. The classes are: - Notification of Unusual Event; - Alert; - Site Emergency; - General Emergency. The rationale for the notification and alert classes is to provide early and prompt notification of minor events which could lead to more serious consequences given operator error or equipment failure or which might be indicative of more serious conditions which are not yet fully realized. A gradation is provided to assure fuller response preparations for more serious indicators. The site emergency class reflects conditions where some significant releases are likely or are occurring but where a core melt situation is not indicated based on current information. In this situation full mobilization of emergency personnel in tie :near site environs is indicated as well as dispatch of monitoring teams and associated communications. The general emergency class involves actual or imminent substantial core degradation or malting with the potential for loss of containment. The immediate action for this class is sheltering (staying inside) rather thai evacuation until an assessment can be made that (1) an evacuation is indicated and (2) an evacuation, if indicated, can be completed prior to significant release and transport of radioactive material to the affected

  15. 75 FR 69078 - Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA)

    2010-11-10

    ... AGENCY Workshop To Review Draft Materials for the Lead (Pb) Integrated Science Assessment (ISA) AGENCY... a workshop to evaluate initial draft materials for the Pb Integrated Science Assessment (ISA) is... within each discipline to assist EPA in integrating within and across disciplines. This workshop...

  16. 75 FR 69065 - Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk...

    2010-11-10

    ... AGENCY Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk... the draft human health assessment titled, ``Toxicological Review of Urea: In Support of Summary... workshop on the draft assessment for Urea will be held via teleconference on December 13, 2010,...

  17. Review of the draft supplement environmental impact statement

    The Draft Supplement Environmental Impact Statement (SEIS) for WIPP does not provide adequate justification to support the proposed action of shipping up to 620,000 cubic feet of transuranic (TRU) waste to WIPP before demonstrating compliance with the Environmental Protection Agency's (EPA) Standards for Management and Disposal of Spent Nuclear Fuel, High-Level and Transuranic Radioactive Wastes. The ''alternative action'' of shipping no waste to WIPP prior to demonstrating compliance with the EPA Standards has been dismissed without sufficient discussion and justification. The document contains mistakes in calculations, reflects an erroneous knowledge of the history of the project, presents tables without units, and displays an indifference to the statistical precision of predictions. It also does not adequately address the environmental impacts of the potential failure to complete the demonstration of compliance with the EPA Standards by October 1993. By comparison, DOE plans to complete the demonstration of compliance with the same standards before starting construction of the high-level waste repository in Nevada. These two diametrically opposed approaches by DOE, for WIPP and for the Yucca Mountain repository, need to be addressed

  18. IRIS Toxicological Review of Hexavalent Chromium (2010 External Review Draft)

    [UPDATE] New Schedule for IRIS Hexavalent Chromium Assessment In Feb 2012, EPA developed a new schedule for completing the IRIS hexavalent chromium assessment. Based on the recommendations of the external peer review panel, which met in May 2011 to review the dra...

  19. IRIS Toxicological Review of Formaldehyde (Inhalation) (External Review Draft 2010)

    UPDATE EPA is currently revising its Integrated Risk Information System (IRIS) assessment of formaldehyde to address the 2011 NAS peer review recommendations. This assessment addresses both noncancer and cancer human health effects that are relevant to assessing ...

  20. IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft)

    EPA is seeking additional public comment and external peer review of the scientific basis supporting the human health hazard and dose-response assessment of methanol (noncancer). Teleconference Details: The public may participate in th...

  1. IRIS TOXICOLOGICAL REVIEW OF UREA (EXTERNAL REVIEW DRAFT)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Urea that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  2. IRIS Toxicological Review of Trichloroethylene (TCE) (External Review Draft)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of Trichloroethylene (TCE) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  3. IRIS Toxicological Review of Hydrogen Cyanide (External Review Draft)

    EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of hydrogen cyanide and cyanide salts that will appear on the Integrated Risk Information System (IRIS) database.

  4. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Interagency Science Consultation Draft)

    On March 10, 2016, the public comment draft Toxicological Review of Hexahydro-1,3,5-trinitro-1,3,5-triazine and the draft charge to external peer reviewers were released for public review and comment. The Toxicological Review and charge were reviewed internally by EPA and by othe...

  5. IRIS Toxicological Review of Methanol (External Review Draft, 2013)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  6. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (EGBE) (Interagency Science Discussion Draft)

    EPA is releasing the draft report, Toxicological Review for Ethylene Glycol Mono-Butyl Ether , that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessme...

  7. Nanomaterial Case Studies: Nanoscale Titanium Dioxide (External Review Draft)

    This draft document presents two case studies of nanoscale titanium dioxide (nano-TiO2) used (1) to remove arsenic from drinking water and (2) as an active ingredient in topical sunscreen. The draft case studies are organized around a comprehensive environmental asses...

  8. 76 FR 20347 - Release of Draft Integrated Review Plan for the National Ambient Air Quality Standards for Lead

    2011-04-12

    ... (75 FR 8934). The draft IRP is being made available for consultation with CASAC and for public comment... AGENCY Release of Draft Integrated Review Plan for the National Ambient Air Quality Standards for Lead... National Ambient Air Quality Standards for Lead (draft IRP). This document contains the plans for...

  9. 76 FR 21736 - Draft Toxicological Review of Methanol (Non-Cancer) in Support of Summary Information on the...

    2011-04-18

    ... AGENCY Draft Toxicological Review of Methanol (Non-Cancer) in Support of Summary Information on the... Review of Methanol (Non-Cancer): In Support of Summary Information on the Integrated Risk Information... released an external peer review draft IRIS Toxicological Review for methanol...

  10. 78 FR 12764 - Draft Office of Health Assessment and Translation Approach for Systematic Review and Evidence...

    2013-02-25

    ... for Systematic Review and Evidence Integration for Literature-Based Health Assessments--February 2013... comments on the Draft Office of Health Assessment and Translation (OHAT) Approach for Systematic Review and... out literature-based health assessments that incorporates systematic review methodology....

  11. 76 FR 4115 - Request for the Technical Review of the Draft Current Intelligence Bulletin (CIB): Derivation of...

    2011-01-24

    ... Current Intelligence Bulletin (CIB): Derivation of Immediately Dangerous to Life and Health (IDLH) Values... Disease Control and Prevention (CDC) is conducting a public review of the draft, Current...

  12. 76 FR 58311 - Draft License Renewal Interim Staff Guidance LR-ISG-2011-05; Ongoing Review of Operating Experience

    2011-09-20

    ... Guidance (LR-ISG), LR-ISG-2011-05, ``Ongoing Review of Operating Experience.'' This LR-ISG provides... draft LR-ISG-2011-05 to clarify guidance on how the ongoing review of operating experience should be... COMMISSION Draft License Renewal Interim Staff Guidance LR-ISG-2011-05; Ongoing Review of...

  13. Integrated Science Assessment (ISA) for Oxides of Nitrogen and Sulfur Environmental Criteria (First External Review Draft, Dec 2007)

    EPA is announcing that the First External Review Draft of the Integrated Science Assessment (ISA) for Oxides of Nitrogen and Sulfur – Environmental Criteria has been made available for independent peer review and public review. This draft ISA document represents a concise ...

  14. 77 FR 51798 - First Draft Documents Related to the Review of the National Ambient Air Quality Standards for Ozone

    2012-08-27

    ... AGENCY First Draft Documents Related to the Review of the National Ambient Air Quality Standards for... of the Ozone National Ambient Air Quality Standards: First External Review Draft. The Agency is... titled, Policy Assessment for the Review of the Ozone National Ambient Air Quality Standards:...

  15. 76 FR 67439 - External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic...

    2011-11-01

    ... AGENCY External Peer Review Meeting for Draft Microbial Risk Assessment Guideline: Pathogenic... guidance for a 60 day comment period (76 FR 44586-44587). The public comment period ended on September 26... attend this peer review meeting as observers. Time will be set aside at the meeting for observers to...

  16. Technical review of US Department of Energy draft area recommendation report for the crystalline repository project

    Foth and Van Dyke and Associates Inc. was retained by the Stockbridge-Munsee Community to evaluate the DOE's screening process for selection of candidate areas in crystalline rock terranes, and critically review the geologic and environmental factors utilized by the DOE in selecting the NC-3 area as a potentially acceptable site (PAS). We have reviewed the DOE's Draft Area Recommendation Report (ARR) issued in January 1986, and prepared our comments. In addition, geologic and environmental data pertaining to the Stockbridge-Munsee community and vicinity that was not included in the Draft ARR is presented. 24 refs., 7 figs., 4 tabs

  17. NPP Krsko Periodic Safety Review action plan

    In the current, internationally accepted, safety philosophy Periodic Safety Reviews (PSRs) are comprehensive reviews aimed at the verification that an operating NPP remains safe when judged against current safety objectives and practices and that adequate arrangements are in place to maintain an acceptable level of safety. These reviews are complementary to the routine and special safety reviews. They are long time-scale reviews intended to deal with the cumulative effects of plant ageing, modifications, operating experience and technical developments, which are not so easily comprehended over the shorter time-scale routine of safety reviews. The review was completed in 2005 and the next period will see the implementation of the action plan including some plant upgrades. The action plan lists issues that should be implemented at NPP Krsko together with associated milestones. The milestones were assumed based on best estimate resource availability and their ends can be potentially floated. In some cases, multiple corrective measures may be postulated to provide resolution for a given safety issue. The Slovenian Nuclear Safety Administration by decree approved the first periodic safety review and the implementation plan of activities arising from it. The entire implementation plan must be carried out by 15 October 2010. Report on the second periodic safety review must be submitted by the NEK not later than 15 December 2013. (author)

  18. Basins 4.0 Climate Assessment Tool (Cat): Supporting Documentation and User Manual (External Review Draft)

    EPA has released of the draft document solely for the purpose of pre-dissemination peer review under applicable Information Quality Guidelines (IQGs). This document has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agenc...

  19. 75 FR 51838 - Public Review of Draft Coastal and Marine Ecological Classification Standard

    2010-08-23

    ... at its July 20, 2010 meeting. The FGDC invites all stakeholders in coastal and marine ecology and... Geological Survey Public Review of Draft Coastal and Marine Ecological Classification Standard AGENCY... Marine Ecological Classification Standard. SUMMARY: The Federal Geographic Data Committee (FGDC)...

  20. 78 FR 27374 - Workshop To Review Initial Draft Materials for the Nitrogen Oxides (NOX

    2013-05-10

    ...As part of the review of the air quality criteria for nitrogen oxides (NOX) and primary (health-based) National Ambient Air Quality Standards (NAAQS) for nitrogen dioxide (NO2), EPA is announcing a workshop to evaluate preliminary draft materials that will inform the development of the NOX Integrated Science Assessment (ISA) for health effects. The workshop is......

  1. 75 FR 59716 - Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk...

    2010-09-28

    ... AGENCY Draft Toxicological Review of Urea: In Support of Summary Information on the Integrated Risk... Urea: In Support of Summary Information on the Integrated Risk Information System (IRIS)'' [EPA/ 635/R..., 2010. The listening session on the draft assessment for urea will be held on November 16,...

  2. Review of the draft supplement to the WIPP environmental impact statement DOE/EIS-0026-S-2

    New Mexico Environmental Evaluation Group's (EEG) review of the WIPP Disposal Phase Draft Supplemental Environmental Impact Statement (SEIS-II) concentrated on the radiological aspects of the Proposed Action, including transportation. The alternatives were reviewed in less detail. Some calculations were checked, mostly for the Proposed Action. Because of time constraints, there was little review of Hazardous Chemicals, Economics, or other Environmental Assessments. SEIS-II was written as a pre-decision document with the Alternatives all plausible and eligible to be selected. Also, the inventory of TRU waste for disposal went well beyond that portion of TRU waste that has been historically considered to be the WIPP inventory. This broadened scope is probably appropriate for an EIS but it is confusing to the reviewer who is aware of the statutory limits of wastes that are allowed to come to WIPP at the present time. EEG has attempted to keep the broadened scope of SEIS-II in mind during their review. The more important issues discussed within are: alternatives; related documents; transportation; questionable assumptions; use of the 75th percentile values; family farm scenario and inhalation doses; modification of BRAGFLO volumes; emplacement of remotely handled TRU wastes; conversion error; and remotely handled TRU casks

  3. IRIS Toxicological Review of Urea (Interagency Science Consultation Draft)

    On September 28, 2010, the Toxicological Review of Urea and the charge to external peer reviewers were released for external peer review and public comment. The Toxicological Review and charge were reviewed internally by EPA and by other federal agencies and White House Of...

  4. 75 FR 47856 - Draft Emergency Action Level Frequently Asked Questions; Request for Comment

    2010-08-09

    ... available electronically at the NRC's Electronic Reading Room at http://www.nrc.gov/reading-rm/adams.html... Asked Questions is ML102030343. The draft question is also available on the NRC Web site at...

  5. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 6: Controls and guidance

    1991-01-01

    Viewgraphs of briefings from the Space Systems and Technology Advisory Committee (SSTAC)/ARTS review of the draft Integrated Technology Plan (ITP) on controls and guidance are included. Topics covered include: strategic avionics technology planning and bridging programs; avionics technology plan; vehicle health management; spacecraft guidance research; autonomous rendezvous and docking; autonomous landing; computational control; fiberoptic rotation sensors; precision instrument and telescope pointing; microsensors and microinstruments; micro guidance and control initiative; and earth-orbiting platforms controls-structures interaction.

  6. Four Draft Working Papers: PEER REVIEW IN ACADEMIC PROMOTION AND PUBLISHING: Its Meaning, Locus, and Future

    Harley, Diane

    2010-01-01

    As part of its Andrew W. Mellon Foundation-funded Future of Scholarly Communication Project, the Center for Studies in Higher Education (CSHE) has hosted two meetings to explore how peer review relates to scholarly communication and academic values. In preparation for an April 2010 workshop, four working papers were developed and circulated. They are presented as drafts here. (The proceedings from the April 2010 meeting will be published at a future date.) The topics covered include assessing...

  7. Drinking-water-criteria document for radium (draft). Scientific review

    This document reviews the following topics on radium; Physical and chemical properties; Toxicokinetics and human exposure; Health effects; Mechanisms of toxicity; and Quantification of toxicological effects

  8. Development of a draft of human factors safety review procedures for the Korean next generation reactor

    Lee, Jung Woon; Moon, B. S.; Park, J. C.; Lee, Y. H.; Oh, I. S.; Lee, H. C. [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2000-02-01

    In this study, a draft of human factors engineering (HFE) safety review procedures (SRP) was developed for the safety review of KNGR based on HFE Safety and Regulatory Requirements and Guidelines (SRRG). This draft includes acceptance criteria, review procedure, and evaluation findings for the areas of review including HFE Program Management, Human Factors Analyses, Human Factors Design, and HFE Verification and Validation, based on Section 15.1 'Human Factors Engineering Design Process' and 15.2 'Control Room Human Factors Engineering' of KNGR Specific Safety Requirements and Chapter 15 'Human Factors Engineering' of KNGR Safety Regulatory Guides. For the effective review, human factors concerns or issues related to advanced HSI design that have been reported so far should be extensively examined. In this study, a total of 384 human factors issues related to the advanced HSI design were collected through our review of a total of 145 documents. A summary of each issue was described and the issues were identified by specific features of HSI design. These results were implemented into a database system. 8 refs., 2 figs. (Author)

  9. Development of a draft of human factors safety review procedures for the Korean Next Generation Reactor

    In this study, a draft of Human Factors Engineering (HFE) Safety Review Procedures (SRP) was developed for the safety review of KNGR based on HFE Safety and Regulatory Requirements and Guidelines (SRRG). This draft includes acceptance criteria, review procedure, and evaluation findings for the areas of review including HFE program management, human factors analyses, human factors design, and HFE verification and validation, based on section 15.1 'human factors engineering design process' and 15.2 'control room human factors engineering' of KNGR specific safety requirements and chapter 15 'human factors engineering' of KNGR safety regulatory guides. For the effective review, human factors concerns or issues related to advanced HSI design that have been reported so far should be extensively examined. In this study, a total of 384 human factors issues related to the advanced HSI design were collected through our review of a total of 145 documents. A summary of each issue was described and the issues were identified by specific features of HSI design. These results were implemented into a database system

  10. 76 FR 52995 - Draft License Renewal Interim Staff Guidance LR-ISG-2011-05: Ongoing Review of Operating...

    2011-08-24

    ... Interim Staff Guidance (LR-ISG), LR-ISG-2011-05, ``Ongoing Review of Operating Experience.'' This LR-ISG... draft LR-ISG-2011-05 to clarify guidance on how the ongoing review of operating experience should be... applicants should obligate themselves to the ongoing review of operating experience for license renewal....

  11. 75 FR 10252 - Release of Draft Documents Related to the Review of the National Ambient Air Quality Standards...

    2010-03-05

    ... Exposure Assessment to Support the Review of the Carbon Monoxide Primary National Ambient Air Quality... draft assessment document: Policy Assessment for the Review of the Carbon Monoxide National Ambient Air... Risk and Exposure Assessment to Support the Review of the Carbon Monoxide Primary National Ambient......

  12. 77 FR 56202 - Notification of an External Peer Review Meeting for the Draft Framework for Human Health Risk...

    2012-09-12

    ... AGENCY Notification of an External Peer Review Meeting for the Draft Framework for Human Health Risk... external peer review meeting. SUMMARY: The EPA Office of the Science Advisor announces that Versar, Inc., a... attend this peer review meeting as an observer. Time will be set aside for observers to give brief...

  13. HERBAL REMEDIES FOR GASTROPROTECTIVE ACTION: A REVIEW

    Ramesh Patel

    2012-05-01

    Full Text Available Herbal medicines have great importance in maintaining the health of every person. Demands of Herbal medicines are increasing in both developed and developing countries due to growing recognition of natural plants being lesser no. of side effect, easily available in surrounding place with low coast. Different parts of the plant have different active substances and these active substances may vary in their extent of activity and concentration. Most of active principles are present in leaves, flower, fruit, bark, root & seeds of the plant. Gastric diseases are a major and worldwide very common problem in every age of person. Its 90% arises commonly due to mostly used of non-steroidal anti-inflammatory category of drug and about 8 to 10% by used of most spicy and fast food(Junk Food. In this review we have described some medicinal plants with respect to their Gastroprotective action.

  14. Drinking-water criteria document for radon (draft). Scientific review

    The Office of Drinking Water (ODW), U.S. Environmental Protection Agency has prepared a Drinking Water Criteria Document on Radon. The document is an extensive review of radon on the following topics: Physical and chemical properties; Toxicokinetics and human exposure; Health effects of radon; Mechanisms of toxicity of radon; Quantification of toxicological effects

  15. Human-factors engineering-control-room design review: Shoreham Nuclear Power Station. Draft audit report

    A human factors engineering preliminary design review of the Shoreham control room was performed at the site on March 30 through April 3, 1981. This design review was carried out by a team from the Human Factors Engineering Branch, Division of Human Factors Safety. This report was prepared on the basis of the HFEB's review of the applicant's Preliminary Design Assessment and the human factors engineering design review/audit performed at the site. The presented sections are numbered to conform to the guidelines of the draft version of NUREG-0700. They summarize the teams's observations of the control room design and layout, and of the control room operators' interface with the control room environment

  16. 76 FR 55384 - External Peer Review Meeting for the Draft Guidance of Applying Quantitative Data To Develop Data...

    2011-09-07

    ... AGENCY External Peer Review Meeting for the Draft Guidance of Applying Quantitative Data To Develop Data... period (76 FR 33752-33753), which was subsequently extended to 60 days (76 FR 43999). The public comment... register to attend this peer review meeting as observers. Time will be set aside for observers to...

  17. The process of consensus on EMF: SAB review of the EPA draft document on EMF and cancer

    Wilson, B. W.

    1992-06-01

    The EPA Draft Document on EMF and Cancers grew out of an earlier effort by EPA to track biological effects literature relative to radio-frequency (RF) exposure. Scope of the document was broadened to include extremely low frequency electric and magnetic fields prior to an announcement in 1986 that EPA would formally review the whole area of non-ionizing radiation. An extensive survey of the relevant bioeffects and epidemiologic literature was carried out, and writing on the document began in earnest on the document sometime in 1989. In its draft form, the document reviewed the literature on mechanisms of Interaction between electromagnetic fields and biological tissue, EMF epidemiologic studies, supporting evidence for carcinogenicity and research needs. In the early summer of 1990, a draft of the document was reviewed by some 22 individuals within the EPA and other government agencies. It was also sent out for external review to an additional 9 qualified scientists who had worked in the area and were familiar with EMF-related literature in epidemiology, biology, and physics. Many of the comments sent to EPA from this first review, prior to release of the draft for public comment, were strikingly similar to those resulting from the second (public) review process. Thus, it appears that much of the controversy that was later associated with the document could have been avoided had the authors been diligent in following the recommendations of the initial set of reviewers.

  18. 77 FR 38296 - Draft Public Health Action Plan-A National Public Health Action Plan for the Detection...

    2012-06-27

    ... Detection, Prevention, and Management of Infertility (77 FR 28883). Written and electronic comments were to... male and female infertility, the plan outlines and summarizes actions needed to promote, preserve, and... Public Health Action Plan for the Detection, Prevention, and Management of Infertility AGENCY:...

  19. 77 FR 2292 - Request for Nominations for Peer Reviewers for the Draft Research Report Entitled, “Investigation...

    2012-01-17

    ... December 14, 2011 (see Federal Register Vol. 76, No. 240 at http://www.gpo.gov/fdsys/pkg/FR-2011-12-14/pdf/FR-2011-12-14.pdf ). This draft report is not final as described in EPA's Information Quality... their current email address or other contact information. ADDRESSES: Peer reviewer...

  20. 78 FR 9387 - Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation Plan

    2013-02-08

    ... AGENCY Notice of Availability for Public Review and Comment: Draft EPA Climate Change Adaptation Plan... Agency Climate Change Adaptation Plans in response to the President's October 2009 Executive Order (E.O... of EPA's Climate Change Adaptation Plan has been posted to a public docket and is available on...

  1. 75 FR 71702 - Science Advisory Board Staff Office; Request for Nominations of Experts for Review of EPA's Draft...

    2010-11-24

    ... gathered by the SAB Staff Office. Selection criteria to be used for Panel membership include: (a... AGENCY Science Advisory Board Staff Office; Request for Nominations of Experts for Review of EPA's Draft... Board (SAB) Staff Office is requesting public nominations for technical experts to augment the...

  2. 75 FR 47346 - Draft Strategic Plan for FY 2010-2015

    2010-08-05

    ..., 2010. Martin R. Melone, Director, Strategic Planning and Performance Management, United States... Draft Strategic Plan for FY 2010-2015 AGENCY: United States Department of the Treasury. ACTION: Notice... draft strategic plan for fiscal years 2010-2015 is available for public review and comment....

  3. Building Capacity through Action Research Curricula Reviews

    Lee, Vanessa; Coombe, Leanne; Robinson, Priscilla

    2015-01-01

    In Australia, graduates of Master of Public Health (MPH) programmes are expected to achieve a set of core competencies, including a subset that is specifically related to Indigenous health. This paper reports on the methods utilised in a project which was designed using action research to strengthen Indigenous public health curricula within MPH…

  4. A scoping review of definitions and frameworks of intersectoral action

    Alejandra Dubois; Louise St-Pierre; Mirella Veras

    2015-01-01

    AbstractIntersectoral action is rooted in all health promotion activities because the determinants of health lie outside of the health sector. Despite the increasing use of these terms (intersectoral action, intersectoral action for health, intersectoral collaboration), often interchangeably, we noted a lack of consensus on their definitions and conceptualizations. The objective of this paper is to report the results of a scoping review of the use of definitions for a set of related terms as ...

  5. An early review of the performance assessment in the draft compliance certification application for the Waste Isolation Pilot Plant

    On March 31, 1995, the US Department of Energy filed a draft application for certification of compliance with the US Environmental Protection Agency (USEPA) to show the Waste Isolation Pilot Plant's compliance with the USEPA's environmental standards, making the application the first of its kind. Demonstration of compliance is by performance assessment. This paper is an early review of the performance assessment in the draft application, by the Environmental Evaluation Group, an oversight group. The performance assessment in the draft application is incomplete. Not all relevant scenarios have been analyzed. The calculation of potential consequences often does not use experimental data but rather estimates by workers developing additional data. The final compliance application, scheduled for October 1996 needs to consider additional scenarios, and be fully based on experimental data

  6. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  7. Epoxide compositions, solidifying under radiation action (Review)

    A review on radiation hardening of epoxy oligomers is presented. The coatings on their basis possess a complex of high physicomechanical properties. It is shown that the investigations on radiation hardening of epoxy oligomers are carried out in two directions: preparation of unsaturated epoxyester acrylates and application of epoxy resin mixtures with traditional hardeners

  8. [Review comments on the Draft DOE Area Recommendation Report for the Crystalline Repository Project]: Final technical report

    Research performed under the grant primarily involved review and comment on the Draft Area Recommendations Report (DARR). However, because data and ''recommendations'' included in the DARR are unquestionably tied to years of research and dozens of technical reports and documents, i.e., Screening Methodologies, Regional characterization Reports, etc., it is essential that consultants to the Menominee Tribe review all the relevant DOE documents, working papers, etc. Given the short period provided for technical comment and limited funds available to the Tribe, a well designed and thorough technical review was (and is) without question impossible. What review and comment that did occur on a geotechnical level is included in this report

  9. Draft programmatic environmental impact statement for the Uranium Mill Tailings Remedial Action Ground Water Project

    The US Department of Energy (DOE) is responsible for performing remedial action to bring surface and ground water contaminant levels at 24 inactive uranium processing sites into compliance with the US Environmental Protection Agency (EPA) standards. DOE is accomplishing this through the Uranium Mill Tailings Remedial Action (UMTRA) Surface and Ground Water Projects. Remedial action will be conducted with the concurrence of the US Nuclear Regulatory Commission (NRC) and the full participation of affected states and Indian tribes. Uranium processing activities at most of 24 the inactive mill sites resulted in the contamination of ground water beneath and, in some cases, downgradient of the sites. This contaminated ground water often has elevated levels of constituents such as uranium and nitrate. The purpose of the UMTRA Ground Water Project is to eliminate, or reduce to acceptable levels, the potential health and the environmental consequences of milling activities by meeting the EPA standards in areas where ground water has been contaminated. The first step in the UMTRA Ground Water Project is the preparation of this programmatic environmental impact statement (PEIS). This document analyzes potential impacts of four programmatic alternatives, including the proposed action. The alternatives do not address site-specific ground water compliance strategies. Rather, the PEIS is a planning document that provides a framework for conducting the Ground Water Project; assesses the potential programmatic impacts of conducting the Ground Water Project; provides a method for determining the site-specific ground water compliance strategies; and provides data and information that can be used to prepare site-specific environmental impacts analyses more efficiently

  10. Draft Hanford Remedial Action Environmental Impact Statement and Comprehensive Land Use Plan: Volume 1 of 4

    This document analyzes the potential environmental impacts associated with establishing future land-use objectives for the US Department of Energy's Hanford Site. Impact analysis is performed by examining the consequences (primarily from remediation activities) of the actions determined necessary to achieve a desired future land-use objective. It should be noted that site-specific decisions regarding remediation technologies and remediation activities would not be made by this document, but rather by processes specified in the Comprehensive Environmental Response, Compensation and Liability Act of 1980 and the Resource Conservation and Recovery Act of 1976. To facilitate the establishment of future land-use objectives, the Hanford Site was divided into four geographic areas: (1) Columbia River; (2) reactors on the river; (3) central plateau; (4) all other areas. The future land-use alternatives considered in detail for each of the geographic areas are as follows: Columbia River--unrestricted and restricted; reactors on the river--unrestricted and restricted; central plateau--exclusive; all other areas--restricted. A No-Action Alternative also is included to provide a baseline against which the potential impacts of the proposed action can be assessed

  11. Draft Hanford Remedial Action Environmental Impact Statement and Comprehensive Land Use Plan: Summary

    This document analyzes the potential environmental impacts associated with establishing future land-use objectives for the US Department of Energy's Hanford Site. Impact analysis is performed by examining the consequences (primarily from remediation activities) of the actions determined necessary to achieve a desired future land-use objective. It should be noted that site-specific decisions regarding remediation technologies and remediation activities would not be made by this document, but rather by processes specified in the Comprehensive Environmental Response, Compensation and Liability Act of 1980 and the Resource Conservation and Recovery Act of 1976. To facilitate the establishment of future land-use objectives, the Hanford Site was divided into four geographic areas: (1) Columbia River; (2) reactors on the river; (3) central plateau; (4) all other areas. The future land-use alternatives considered in detail for each of the geographic areas are as follows: Columbia River--unrestricted and restricted; reactors on the river--unrestricted and restricted; central plateau--exclusive; all other areas--restricted. A No-Action Alternative also is included to provide a baseline against which the potential impacts of the proposed action can be assessed

  12. Review of remedial actions applied at shallow land burial facilities

    Evaluation Research Corporation's Oak Ridge Operations office recently completed a review of remedial actions taken to correct problems at shallow land burial (SLB) facilities operating in the US. Two staff members from Evaluation Research Corporation's Oak Ridge Operations office recently visited eleven shallow land burial facilities to observe routine operations and remedial action activities. At each of these facilities, selected problems and remedial actions were identified and documented. The main problem areas for which remedial actions are taken include water management, subsidence, wind erosion, and biological intrusion. In addition, other site management considerations are discussed in the document prepared for the DOE-Low Level Waste Management Program. These include waste packaging, space utilization, physicochemical reactions facilitating migration of radionuclides, gas phase migration, trade-offs, improved practices, and future remedial actions. The review of remedial actions taken at SLB facilities revealed that the application and evaluation of remedial actions at operating SLB facilities are not well documented. This lack of documentation may be due to two factors. First, operations personnel are primarily involved with the implementation and modification of operating procedures, whereas research-related efforts to identify problems are more likely to find their way into the literature. Second, the recent concerns with problems at SLB facilities may have resulted in recent application of remedial actions

  13. A review of action estimation methods for galactic dynamics

    Sanders, Jason L

    2015-01-01

    We review the available methods for estimating actions, angles and frequencies of orbits in both axisymmetric and triaxial potentials. The methods are separated into two classes. Unless an orbit has been trapped by a resonance, convergent, or iterative, methods are able to recover the actions to arbitrarily high accuracy given sufficient computing time. Faster non-convergent methods rely on the potential being sufficiently close to a separable potential and the accuracy of the action estimate cannot be improved through further computation. We critically compare the accuracy of the methods and the required computation time for a range of orbits in an axisymmetric multi-component Galactic potential. We introduce a new method for estimating actions that builds on the adiabatic approximation of Sch\\"onich & Binney (2012) and discuss the accuracy required for the actions, angles and frequencies using suitable distribution functions for the thin and thick discs, the stellar halo and a star stream. We conclude t...

  14. Revised draft Hanford remedial action environmental impact statement and comprehensive land-use plan

    This report evaluates the potential environmental impacts associated with implementing a comprehensive land-use plan for the Hanford Site for at least the next 50 years. With the exception of the required No-Action Alternative, each of the six alternatives presented represents a Tribal, Federal, state, or local agency's Preferred Alternative. Each alternative is presented separately. The DOE's Preferred Alternative anticipates multiple uses of the Hanford Site, including: consolidating waste management operations in the Central Plateau, allowing industrial development in the eastern and southern portions of the site, increasing recreational access to the Columbia River, and expanding the Saddle Mountain National Wildlife Refuge to include all of the Wahluke Slope (managed by the US Fish and Wildlife Service). The Hanford Site occupies 1,517 square kilometers (km2) (586 square miles [mi2]) in southeastern Washington. Today, the Hanford Site has diverse missions associated with environmental restoration, waste management, and science and technology. These missions have resulted in the growing need for a comprehensive, long-term approach to planning and development for the Site

  15. Canadian support for population stabilization. The Rome draft Plan of Action. Dr. Jean Augustine, MP (Canada).

    1996-01-01

    Canada strongly believes in the central role to be played by the civil sector in the process leading to the World Food Summit. Dr. Augustine, Member of Parliament of Canada, described how the Canadian Government involved 350 national organizations over an eight-month period in the creation of the country's official position on food security. Canada has also negotiated with several other countries and international organizations on issues such as trade, human rights, the right to food, and follow-up to the Plan of Action. Dr. Augustine summarized Canada's 18 priorities for the World Food Summit. The priorities include human rights and good governance; poverty reduction; peace, security and conflict resolution; national responsibility for food security; national and global partnerships; nutrition and health; human resource development; gender equity; population stabilization; trade liberalization; agricultural adjustment to international markets; post-harvest marketing and food marketing; the role of the private sector; capacity building; environment and sustainable production; and research and technology transfer. PMID:12292041

  16. Revised draft Hanford remedial action environmental impact statement and comprehensive land-use plan: Executive summary

    This report evaluates the potential environmental impacts associated with implementing a comprehensive land-use plan for the Hanford Site for at least the next 50 years. With the exception of the required No-Action Alternative, each of the six alternatives presented represents a Tribal, Federal, state, or local agency's Preferred Alternative. Each alternative is presented separately. The DOE's Preferred Alternative anticipates multiple uses of the Hanford Site, including: consolidating waste management operations in the Central Plateau, allowing industrial development in the eastern and southern portions of the site, increasing recreational access to the Columbia River, and expanding the Saddle Mountain National Wildlife Refuge to include all of the Wahluke Slope (managed by the US Fish and Wildlife Service). The Hanford Site occupies 1,517 square kilometers (km2) (586 square miles [mi2]) in southeastern Washington. Today, the Hanford Site has diverse missions associated with environmental restoration, waste management, and science and technology. These missions have resulted in the growing need for a comprehensive, long-term approach to planning and development for the Site

  17. IRIS Toxicological Review of Ethylene Glycol Mono-Butyl Ether (Egbe) (External Review Draft)

    EPA has conducted a peer review of the scientific basis supporting the human health hazard and dose-response assessment of ethylene glycol monobutyl ether that will appear on the Integrated Risk Information System (IRIS) database.

  18. 76 FR 38166 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    2011-06-29

    ...-HQ-OPP-2011-0482 Eric Miederhoff, (703) 347-8028, miederhoff.eric@epa.gov . Bacillus cereus, 6053... AGENCY Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions... review dockets for the pesticides listed in the table in Unit III.A. With this document, EPA is...

  19. IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of methanol (non-cancer) that when finalized will appear on the Integrated Risk Information System (IRIS) database.

  20. A review of action estimation methods for galactic dynamics

    Sanders, Jason L.; Binney, James

    2016-04-01

    We review the available methods for estimating actions, angles and frequencies of orbits in both axisymmetric and triaxial potentials. The methods are separated into two classes. Unless an orbit has been trapped by a resonance, convergent, or iterative, methods are able to recover the actions to arbitrarily high accuracy given sufficient computing time. Faster non-convergent methods rely on the potential being sufficiently close to a separable potential, and the accuracy of the action estimate cannot be improved through further computation. We critically compare the accuracy of the methods and the required computation time for a range of orbits in an axisymmetric multicomponent Galactic potential. We introduce a new method for estimating actions that builds on the adiabatic approximation of Schönrich & Binney and discuss the accuracy required for the actions, angles and frequencies using suitable distribution functions for the thin and thick discs, the stellar halo and a star stream. We conclude that for studies of the disc and smooth halo component of the Milky Way, the most suitable compromise between speed and accuracy is the Stäckel Fudge, whilst when studying streams the non-convergent methods do not offer sufficient accuracy and the most suitable method is computing the actions from an orbit integration via a generating function. All the software used in this study can be downloaded from https://github.com/jls713/tact.

  1. Connectivity of Streams and Wetlands to Downstream Waters: A Review and Synthesis of the Scientific Evidence (External Review Draft)

    The Environmental Protection Agency – through the independent Scientific Advisory Board (SAB) - is soliciting public comment on a new draft science report titled: Connectivity of Streams and Wetlands to Downstream Waters. A public docket has been opened to receive com...

  2. [Action modes of chlorine dioxide--a review].

    Wei, Mingken; Lai, Jieling; Zhan, Ping

    2012-04-01

    Chlorine dioxide (ClO2) is a highly effective disinfectant for food and potable water treatment. Till now, the action mode of ClO2 is still unclear. ClO2, can denature proteins by oxidizing tyrosine, tryptophan, and cysteine. We reviewed the pathways by which ClO02 reacts with important bio-molecules, as well as the primary target sites at individual cellular level of ClO2-induced biocidal effects. PMID:22799207

  3. 78 FR 42086 - Draft Guidance for Industry on Arsenic in Apple Juice: Action Level; Supporting Document for...

    2013-07-15

    ... and achievable with the use of good manufacturing practices. It also describes FDA's intended sampling... to be protective of human health and to be achievable with the use of good manufacturing practices... with FDA's good guidance practices regulation (21 CFR 10.115). The draft guidance, when finalized,...

  4. Crystalline Repository Project: Review and comment of the Leech Lake Reservation Business Committee: Draft area recommendation report

    The Leech Lake Reservation Business Committee (LLRBC) has reviewed five documents related to the US Department of Energy's Crystalline Repository Project (CRP). They are the ''National Survey of Crystalline Rocks,'' ''General Guidelines for the Recommendation of Sites for the Nuclear Waste Repositories;' Final Siting Guidelines (10 CFR Part 960),'' ''Regional Characterization Reports for the North Central Region,'' the ''Region to Area Screening Methodology Document'' (SMD) and the ''Draft Area Recommendation Report'' (DARR). The comments and discussions of issues contained in this review will be considered in the preparation of the Final Area Recommendation Report, which will formally identify potentially acceptable sites for a second national repository for the permanent disposal of high level nuclear waste. Following a review of the above referenced documents, the LLRBC has concluded that the identification of potentially acceptable sites in the Draft Area Recommendation Report is based upon inferior and incomplete technical information being applied to a flawed screening process which, among other deficiencies, pays little attention to the importance of hydrological factors in the siting process. Although the DOE prefers that comments from states and tribes be directed at the Draft Area Recommendation Report alone, the Leech Lake Reservation Business Committee is extremely concerned about inadequacies in the ''National Survey of Crystalline Rocks'' (ORCD-1), which serves as the foundation for all siting work done to date. The national survey was conducted utilizing little of the time or staffing required for this important phase of the Crystalline Repository Program. As a result, the national survey is based upon out-of-date scientific literature, exaggerates certain screening variables that favor the selection of regions in the eastern US and arbitrarily eliminated the few western crystalline rock bodies that passed the questionable screening process utilized

  5. A scoping review of definitions and frameworks of intersectoral action.

    Dubois, Alejandra; St-Pierre, Louise; Veras, Mirella

    2015-10-01

    Intersectoral action is rooted in all health promotion activities because the determinants of health lie outside of the health sector. Despite the increasing use of these terms (intersectoral action, intersectoral action for health, intersectoral collaboration), often interchangeably, we noted a lack of consensus on their definitions and conceptualizations. The objective of this paper is to report the results of a scoping review of the use of definitions for a set of related terms as well as for conceptual frameworks, including the discussion of the evolution of those definitions and the sectors that use them. Finally, we propose a single definition for each term. We conducted a systematic search for documents published between January, 1960 and March, 2011 in English, French, Spanish and Portuguese. We retrieved 11 to 15 definitions per main term. Using a content analysis approach, an integrative conceptual definition was proposed for four main terms. Furthermore, in reviewing frameworks for potential use, we noted the lack of a comprehensive framework for intersectoral processes. PMID:26465838

  6. A scoping review of definitions and frameworks of intersectoral action

    Alejandra Dubois

    2015-10-01

    Full Text Available AbstractIntersectoral action is rooted in all health promotion activities because the determinants of health lie outside of the health sector. Despite the increasing use of these terms (intersectoral action, intersectoral action for health, intersectoral collaboration, often interchangeably, we noted a lack of consensus on their definitions and conceptualizations. The objective of this paper is to report the results of a scoping review of the use of definitions for a set of related terms as well as for conceptual frameworks, including the discussion of the evolution of those definitions and the sectors that use them. Finally, we propose a single definition for each term. We conducted a systematic search for documents published between January, 1960 and March, 2011 in English, French, Spanish and Portuguese. We retrieved 11 to 15 definitions per main term. Using a content analysis approach, an integrative conceptual definition was proposed for four main terms. Furthermore, in reviewing frameworks for potential use, we noted the lack of a comprehensive framework for intersectoral processes.

  7. BASINS and WEPP Climate Assessment Tools (CAT): Case Study Guide to Potential Applications (External Review Draft)

    This draft report supports application of two recently developed water modeling tools, the BASINS and WEPP climate assessment tools. The report presents a series of short case studies designed to illustrate the capabilities of these tools for conducting scenario based assessments...

  8. Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Second External Review Draft, 2015)

    This draft document provides EPA’s evaluation and synthesis of the most policy-relevant science related to the health effects of oxides of nitrogen. When final, it will provide a critical part of the scientific foundation for EPA’s decision regarding the adequacy of the current ...

  9. 78 FR 23289 - Public Review of Draft National Shoreline Data Content Standard

    2013-04-18

    ... shoreline semantics, data structures and their relationships to builders and users of shoreline data. The... on the FGDC Web site, www.fgdc.gov . DATES: Comments on the draft Coastal and Marine Ecological... providing technical guidance on shoreline semantics, data structures and their relationships to builders...

  10. 75 FR 36371 - Draft Environmental Impact Statement Addressing Campus Development at Fort Meade, MD

    2010-06-25

    ... requirements and for Intelligence Community use. The purpose of the proposed action is to provide facilities that are fully-supportive of the Intelligence Community's mission. The action is driven by the need to... participate in the public review process. The public comment period for the Draft EIS will officially end...

  11. Scales, strategies and actions for effective energy planning: A review

    This paper is a review of the most recent literature on the interaction between climate change, land-use and energy, based on the analysis of papers collected through the most relevant scientific literature databases. A total of 114 papers published between 2000 and 2011 were reviewed. The aims of this review are: in general (1) to identify the different research topics that have been developed related to the interaction between climate change, land-use and energy; more specifically, (2) to analyze what are the most suitable spatial and temporal scales of investigation to focus on for actions and strategies to reduce critical issues in the field of energy and environment; (3) to identify which actions and strategies are deemed as the most appropriate to mitigate critical issues in energy and environment; and given the research gaps found in the review, (4) to propose research recommendations in the context of effective climate-energy planning. We argue that there are certain gaps and needs for a “nested” environmental governance. It is necessary to understand how different environmental policies overlap and how they can be integrated in order to verify whether there are conflicting targets that may negate each other in the long term. - Highlights: • Energy production and consumption can directly or indirectly affect climate change. • Energy sector is influenced directly and indirectly by changes in climate conditions. • Energy sector and climate change affect and limit alternative uses of land, causing land-use changes. • The most suitable spatial scale for energy planning is the municipal level requiring short-term perspectives. • Several research recommendations to deal with the complexity of energy-land-use-climate change issue are proposed

  12. Corrective Action Investigation Plan for Corrective Action Unit 556: Dry Wells and Surface Release Points Nevada Test Site, Nevada (Draft), Revision 0

    Grant Evenson

    2007-02-01

    Corrective Action Unit  (CAU) 556, Dry Wells and Surface Release Points, is located in Areas 6 and 25 of the Nevada Test Site, 65 miles northwest of Las Vegas, Nevada. Corrective Action Unit 556 is comprised of four corrective action sites (CASs) listed below: •06-20-04, National Cementers Dry Well •06-99-09, Birdwell Test Hole •25-60-03, E-MAD Stormwater Discharge and Piping •25-64-01, Vehicle Washdown and Drainage Pit These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives. Additional information will be obtained by conducting a corrective action investigation before evaluating corrective action alternatives and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable corrective action alternatives that will be presented in the Corrective Action Decision Document.

  13. Towards new educational potentialities: Review and commentary of the Preliminary draft Act on higher education

    Madžar Ljubomir

    2005-01-01

    Full Text Available The Higher Education Act is a long-awaited legal act. A number of uncompleted attempts to prepare it have been undertaken in the course of the last three years. So far without success. Having been and still being a matter of highest social priority, the renewed effort to create and subsequently to enact this act is welcome as a worthwhile and a highly productive endeavor. Welcome also are the main innovations offered by this act, particularly its conspicuous consistency with the Bologna Declaration and other internationally launched and accepted documents. The draft act follows the international documents tracing down the paths of the future development of the educational systems of the European countries and providing for their mutual compatibility. A number of other positive contributions of the draft act are singled out, such as introducing clear and rigorous criteria and procedures for accreditation and quality control, introducing a wide coverage of arts and sciences as a precondition for an institution of higher education to qualify as a university, flexibility in the regime of studying including the domestic and international mobility of the students and requirement for the schools of higher education to have large cores of permanently employed teaching staff. A much larger part of the paper is, however, devoted to critical commentaries. To begin with, the draft is produced without any participation of the private universities, which is seen as a form of discrimination. The organizational pattern of a university is laid out with insufficient clarity and the status of departments (faculties is particularly short of precision and even contradictory. The draft seems to be laden with the old bias towards excessive and potentially disastrous centralization, drastically reducing the decision making capacity of the system. The treatment of the property of the departments (faculties is found inconsistent and legally unfounded. Inconsistency is

  14. 75 FR 81643 - Hydropower Resource Assessment at Existing Reclamation Facilities-Draft Report

    2010-12-28

    ..., 2010 (75 FR 67993). The public review period was originally to end on December 6, 2010. DATES: Submit... Bureau of Reclamation Hydropower Resource Assessment at Existing Reclamation Facilities--Draft Report AGENCIES: Bureau of Reclamation, Interior. ACTION: Reopening of comment period for review of the...

  15. Lessons learned from the preclosure performance assessment review of the Fluor Technology, Inc., draft site characterization plan conceptual design report

    This report presents the lessons learned from the preclosure performance assessment review (PAR) of the Draft Site Characterization Plan---Conceptual Design Report (SCP-CDR). The PAR analyzes the operations of the waste handling facilities as presented in the SCP-CDR against appropriate regulatory and design criteria. The PAR applies to the design presented in a working draft released in April, 1986. We will analyze the design presented in the SCP-CDR, the other is to test safety assessment methods and tools. This report addresses only the second of these objectives. The PAR analysis consists of assessments of offsite and occupational doses resulting from routine and accidental events during preclosure operations at the repository. The activities related to the PAR are divided into subject areas. These areas include (1) the description of repository facilities and operations, (2) the development of radioactive material inventories and radiation dose rates, (3) the development of radioactive material-release scenarios and source terms, (4) the assessment of offsite dose equivalents, and (5) the assessment of occupational radiation dose equivalents. This report contains a summary of the analyses in these fives areas and lists those preclosure analyses not performed as part of the PAR. Chapters detail the strengths and weaknesses of each analysis and include recommendations for improving the analyses. 15 refs., 1 fig., 1 tab

  16. Multitarget stool DNA for colorectal cancer screening: A review and commentary on the United States Preventive Services Draft Guidelines

    Berger, Barry M; Levin, Bernard; Hilsden, Robert J

    2016-01-01

    Multitarget stool DNA (mt-sDNA) testing was approved for average risk colorectal cancer (CRC) screening by the United States Food and Drug Administration and thereafter reimbursed for use by the Medicare program (2014). The United States Preventive Services Task Force (USPSTF) October 2015 draft recommendation for CRC screening included mt-sDNA as an “alternative” screening test that “may be useful in select clinical circumstances”, despite its very high sensitivity for early stage CRC. The evidence supporting mt-sDNA for routine screening use is robust. The clinical efficacy of mt-sDNA as measured by sensitivity, specificity, life-years gained (LYG), and CRC deaths averted is similar to or exceeds that of the other more specifically recommended screening options included in the draft document, especially those requiring annual testing adherence. In a population with primarily irregular screening participation, tests with the highest point sensitivity and reasonable specificity are more likely to favorably impact CRC related morbidity and mortality than those depending on annual adherence. This paper reviews the evidence supporting mt-sDNA for routine screening and demonstrates, using USPSTF’s modeling data, that mt-sDNA at three-year intervals provides significant clinical net benefits and fewer complications per LYG than annual fecal immunochemical testing, high sensitivity guaiac based fecal occult blood testing and 10-year colonoscopy screening. PMID:27190584

  17. Plan of Action: JASPER Management Prestart Review (Surrogate Material Experiments)

    undergone appropriate formal engineering design reviews. This MPR will affirm the quality of those reviews, their findings/resolutions, and will look most closely at systems integration requirements and demonstrations that will have undergone technical acceptance reviews before the formal MPR action. Closure of MPR findings will finalize requirements for a DOE/NV Real Estate/Operations Permit (REOP) for surrogate-material experiments. Upon completion of that experiment series and the establishment of capabilities for incorporating SNM into future experiments, the team will convene again as part of the process of authorizing those activities

  18. IRSN review 2011/2014. Openness to society - Review of actions, 5 years after the chart

    After having recalled the commitments defined by the Charter for Openness to Society adopted by the IRSN in 2009, this report proposes a review of undertaken and performed actions in terms of access to information, of openness to partnership (notably with local information commissions or CLIs, and also with other local actors), of influence of the openness on the Institute work orientation, and of internal culture of openness

  19. Radioactive waste isolation in salt: Peer review of the Golder Associates draft test plan for in situ testing in an exploratory shaft in salt

    Hambley, D.F.; Mraz, D.Z.; Unterberter, R.R.; Stormont, J.C.; Neuman, S.P.; Russell, J.E.; Jacoby, C.H.; Hull, A.B.; Brady, B.H.G.; Ditmars, J.D.

    1987-01-01

    This report documents the peer review conducted by Argonne National Laboratory of a document entitled ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared for Battelle Memorial Institute's Office of Nuclear Waste Isolation by Golder Associates, Inc. In general, the peer review panelists found the test plan to be technically sound, although some deficiencies were identified. Recommendations for improving the test plan are presented in this review report. A microfiche copy of the following unpublished report is attached to the inside back cover of this report: ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared by Golder Associates, Inc., for Office of Nuclear Waste Isolation, Battelle Memorial Institute, Columbus, Ohio (March 1985).

  20. Radioactive waste isolation in salt: Peer review of the Golder Associates draft test plan for in situ testing in an exploratory shaft in salt

    This report documents the peer review conducted by Argonne National Laboratory of a document entitled ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared for Battelle Memorial Institute's Office of Nuclear Waste Isolation by Golder Associates, Inc. In general, the peer review panelists found the test plan to be technically sound, although some deficiencies were identified. Recommendations for improving the test plan are presented in this review report. A microfiche copy of the following unpublished report is attached to the inside back cover of this report: ''Draft Test Plan for In Situ Testing in an Exploratory Shaft in Salt,'' prepared by Golder Associates, Inc., for Office of Nuclear Waste Isolation, Battelle Memorial Institute, Columbus, Ohio (March 1985)

  1. Standard review plan for the review of environmental restoration remedial action quality assurance program plans

    This plan establishes both the scope of the review and the acceptance criteria to be utilized for the review of Quality Assurance Program Plans (QAPPs) developed in accordance with the requirements of DOE/RL-90-28. DOE/RL-90-28, the Environmental Restoration Remedial Action Quality Assurance Requirements Document (QARD) defines all quality assurance (QA) requirements governing activities that affect the quality of the Environmental Restoration Remedial Action (ERRA) program at the Hanford Site. These requirements are defined in three parts, Part 1 of Quality Management and Administration tasks, Part 2 for Environmental Data Operations, and Part 3 of the Design and Construction of items, systems, and facilities. The purpose of this document is to identify the scope of the review by the DOE Field Office, Richland staff, and establish the acceptance criteria (Parts 1, 2, and 3) that the DOE Field Office, Richland staff will utilize to evaluate the participant QAPPs. Use of the standard review plan will (1) help ensure that participant QAPPs contain the information required by DOE/RL-90-28, (2) aid program participant and DOE Field Office, Richland staff is ensuring that the information describing the participant's QAPP is complete, (3) help persons regarding DOE/RL- 90-28 to locate information, and (4) contribute to decreasing the time needed for the review process. In addition, the Standard Review Plan (SRP) ensures the quality and uniformity of the staff reviews and presents a well-defined base from which to evaluate compliance of participant quality programs against DOE/RL-90-28

  2. Development of Action Research in China: Review and Reflection

    Zhou, Jun; Liu, Katrina Yan

    2011-01-01

    Action research in China during late 1970s and 1980s was influenced by positivist scientific research, believing the purpose of doing action research is to explore the general law of education. It was carried out through educational experimentations emphasizing the control of the experimental conditions. Starting from 1990s, action research in…

  3. [Draft] Malheur NWR habitat and wildlife management review : November 13-17, 2000

    US Fish and Wildlife Service, Department of the Interior — This report summarizes the findings and recommendations of a wildlife and habitat management review conducted by a review team during November 13-17, 2000 at the...

  4. North Mississippi Refuges Complex Biological Program 'Pulse-Check' Review - DRAFT REPORT

    US Fish and Wildlife Service, Department of the Interior — Biological review for the three refuges of the North Mississippi Refuges Complex is presented. Review is based on an assessment of addressing goals and objectives...

  5. Action Research in Graduate Teacher Education: A Review of the Literature 2000-2015

    Vaughan, Michelle; Burnaford, Gail

    2016-01-01

    This review explores the goals and challenges as well as the policy and programmatic implications of action research in graduate teacher education as evidenced in the published literature. This literature review looks specifically at how action research is being used in graduate teacher education programs as a content area and as a methodology in…

  6. 75 FR 48382 - Draft Regulatory Guide: Issuance, Availability

    2010-08-10

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1228, ``Standard Format and Content...

  7. 75 FR 28073 - Draft Regulatory Guide: Issuance, Availability

    2010-05-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-3039, ``Standard Format and Content...

  8. 77 FR 33489 - Draft Offender Tracking System Standard

    2012-06-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Draft Offender Tracking System Standard AGENCY: National Institute of Justice. ACTION: Notice of Draft Offender Tracking System Standard, Selection and Application Guide,...

  9. SSTAC/ARTS review of the draft Integrated Technology Plan (ITP). Volume 8: Aerothermodynamics Automation and Robotics (A/R) systems sensors, high-temperature superconductivity

    Viewgraphs of briefings presented at the SSTAC/ARTS review of the draft Integrated Technology Plan (ITP) on aerothermodynamics, automation and robotics systems, sensors, and high-temperature superconductivity are included. Topics covered include: aerothermodynamics; aerobraking; aeroassist flight experiment; entry technology for probes and penetrators; automation and robotics; artificial intelligence; NASA telerobotics program; planetary rover program; science sensor technology; direct detector; submillimeter sensors; laser sensors; passive microwave sensing; active microwave sensing; sensor electronics; sensor optics; coolers and cryogenics; and high temperature superconductivity

  10. Review Essay: Getting with the Act of Action Research

    Palmer, Victoria J.

    2009-01-01

    Action research (AR) prides itself on being a field of both theoretical and practical inquiry. Its scholarly identity rests heavily on framing participants as engaged, subjective, and participatory beings who learn and change through research processes. Yet, action research struggles to be considered a rigorous methodological field of inquiry and certainly there have been those who have raised questions about its validity as a research method. Where action research is used, qualifications and...

  11. Remedial action plan for the inactive Uranium Processing Site at Naturita, Colorado. Remedial action plan: Attachment 2, Geology report, Attachment 3, Ground water hydrology report: Working draft

    1994-09-01

    The uranium processing site near Naturita, Colorado, is one of 24 inactive uranium mill sites designated to be cleaned up by the US Department of Energy (DOE) under the Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), 42 USC {section}7901 et seq. Part of the UMTRCA requires that the US Nuclear Regulatory Commission (NRC) concur with the DOE`s remedial action plan (RAP) and certify that the remedial action conducted at the site complies with the standards promulgated by the US Environmental Protection Agency (EPA). This RAP serves two purposes. First, it describes the activities that are proposed by the DOE to accomplish remediation and long-term stabilization and control of the radioactive materials at the inactive uranium processing site near Naturita, Colorado. Second, this RAP, upon concurrence and execution by the DOE, the state of Colorado, and the NRC, become Appendix B of the cooperative agreement between the DOE and the state of Colorado.

  12. Remedial action plan for the inactive Uranium Processing Site at Naturita, Colorado. Remedial action plan: Attachment 2, Geology report, Attachment 3, Ground water hydrology report: Working draft

    The uranium processing site near Naturita, Colorado, is one of 24 inactive uranium mill sites designated to be cleaned up by the US Department of Energy (DOE) under the Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA), 42 USC section 7901 et seq. Part of the UMTRCA requires that the US Nuclear Regulatory Commission (NRC) concur with the DOE's remedial action plan (RAP) and certify that the remedial action conducted at the site complies with the standards promulgated by the US Environmental Protection Agency (EPA). This RAP serves two purposes. First, it describes the activities that are proposed by the DOE to accomplish remediation and long-term stabilization and control of the radioactive materials at the inactive uranium processing site near Naturita, Colorado. Second, this RAP, upon concurrence and execution by the DOE, the state of Colorado, and the NRC, become Appendix B of the cooperative agreement between the DOE and the state of Colorado

  13. 77 FR 69631 - Draft Guidance for IRBs, Clinical Investigators, and Sponsors: IRB Responsibilities for Reviewing...

    2012-11-20

    ... Reducing Burden, Delay, and Ambiguity for Investigators,'' in the Federal Register of July 26, 2011 (76 FR... Sponsors: IRB Responsibilities for Reviewing the Qualifications of Investigators, Adequacy of Research... Responsibilities for Reviewing the Qualifications of Investigators, Adequacy of Research Sites, and...

  14. THYROID FOLLICULAR CELL CARCINOGENESIS: MECHANISTIC AND SCIENCE POLICY CONSIDERATIONS (SAB REVIEW DRAFT)

    A Technical Panel of EPA's Risk Assessment Forum investigated the potential mechanisms of action of agents that cause thyroid follicular tumors in animals and potentially in humans in an effort to develop a scientifically plausible approach for assessing risk due to exposure to t...

  15. Review and comments on draft final report : environmental impact assessment on the Cambodian part of Srepok River due to hydropower development in Vietnam

    NONE

    2006-10-15

    This environmental impact assessment review was written by a coalition of partners working to support communities along the Sesan, Srepok, and Sekong Rivers in Cambodia. The review assessed the adequacy of the draft final report on the environmental impacts of a hydropower development in Vietnam on downstream communities in Cambodia. The review also examined methods of developing compensation and mitigation measures to alleviate negative impacts of the hydropower facility, and evaluated the adequacy of the report for advancing negotiations and consultations and mitigation strategies along the lower Srepok River in Cambodia. The review examined economic losses, the effects of water pollution, disease, water fluctuations, and floods. The review demonstrated that the EIA failed to demonstrate that downstream impacts are manageable or that the benefits of the proposed project outweigh the total cost. It was recommended that the draft final report should be made available for public review in Cambodia. It was concluded that alternative dam designs and operating scenarios for the Vietnamese project should be considered. 6 tabs.

  16. Radioactive waste isolation in salt: Peer review of the Office of Nuclear Waste Isolation's draft report on an issues hierarchy and data needs for site characterization

    At the request of the Salt Repository Project (SRPO), Argonne National Laboratory conducted an independent peer review of a report by the Battelle Office of Nuclear Waste Isolation entitled ''Salt Repository Project Issues Hierarchy and Data Needs for Site Characterization (Draft).'' This report provided a logical structure for evaluating the outstanding questions (issues) related to selection and licensing of a site as a high-level waste repository. It also provided a first estimate of the information and data necessary to answer or resolve those questions. As such, this report is the first step in developing a strategy for site characterization. Microfiche copies of ''Draft Issues Hierarchy, Resolution Strategy, and Information Needs for Site Characterization and Environmental/Socioeconomic Evaluation - July, 1986'' and ''Issues Hierarchy and Data Needs for Site Characterization - February, 1985'' are included in the back pocket of this report

  17. Environmental assessment of remedial action at the Slick Rock uranium mill tailings sites Slick Rock, Colorado. Draft

    NONE

    1993-06-01

    The Uranium Mill Tailings Radiation Control Act of 1978 (UMTRCA) authorized the US Department of Energy (DOE) to clean up two uranium mill tailings processing sites near Slick Rock, Colorado, in San Miguel County. The purpose of the cleanup is to reduce the potential health effects associated with the radioactive materials remaining on the sites and on vicinity properties (VP) associated with the sites. The US Environmental Protection Agency (EPA) promulgated standards for the UMTRCA that contained measures to control the contaminated materials and to protect the groundwater from further degradation. Remedial actions at the Slick Rock sites must be performed in accordance with these standards and with the concurrence of the US Nuclear Regulatory Commission (NRC).

  18. Geochemistry Review Panel report on the SRP geochemistry program and draft geochemistry summary program plan (May, 1986) and discussion of panel recommendations

    The Geochemistry Review Panel (GRP) was established by the Salt Repository Project Office (SRPO) to help evaluate geochemistry-related issues in the US Department of Energy's nuclear waste repository program. The May 1986 meeting of the GRP reviewed the Salt Repository Program (SRP) geochemistry program developed by the Office of Nuclear Waste Isolation (ONWI). This program is described in the Draft Geochemistry Plan of April 9, 1986. This report documents the GRP's comments and recommendations on this subject and the ONWI responses to the specific points raised by the GRP

  19. Review and assessments of potential environmental, health and safety impacts of MHD technology. Final draft

    1978-01-01

    The purpose of this document is to develop an environmental, health and safety (EH and S) assessment and begin a site - specific assessment of these and socio - economic impacts for the magnetohydrodynamics program of the United States Department of Energy. This assessment includes detailed scientific and technical information on the specific EH and S issues mentioned in the MHD Environmental Development Plan. A review of current literature on impact-related subjects is also included. This document addresses the coal-fired, open-cycle MHD technology and reviews and assesses potential EH and S impacts resulting from operation of commercially-installed technology.

  20. [Review of draft Crystalline Repository Project reports]: Technical progress report, CY 1985-1986

    During the period (CY 1985-86) of this report, the Wisconsin Radioactive Waste Review Board provided technical services under the contract with DOE. These included Participation in the development of variables and screening techniques that would be used in identifying those rock bodies in the Area Recommendation Report (ARR); reviewing and commenting on the report and developing a procedure in which local residents could have input into the process; sought resumption of negotiations with DOE on a full Consultation and Cooperation (CandC) agreement; and Participating in workshops and provided comments on two major DOE transportation documents, ''Transportation Business Plan: Strategy Options Document,'' and ''Transportation Institutional Plan.''

  1. Human-system interface design review guideline: The development of draft revision 1 to NUREG-0700

    O`Hara, J.; Stubler, W.; Brown, W. [Brookhaven National Lab., Upton, NY (United States)] [and others

    1996-03-01

    Advanced human-system interface (HSI) technologies are being developed in the commercial nuclear power industry. These HSIs may have significant implications for plant safety in that they will affect the ways in which the operator interacts with and supervises an increasingly complex system. The U.S. Nuclear Regulatory Commission (NRC) reviews the HSI aspects of nuclear plants to ensure that operator performance and reliability are supported. The NRC is developing guidance to support its review of these advanced designs. The guidance consists of an evaluation methodology and an extensive set of human factors guidelines which are used in one aspect of the evaluation. The paper describes the guidance development of the evaluation methodology and the guidelines.

  2. Community Addiction Response Programme CARP Killinarden: review and interim evaluation report, final revised draft.

    Bowden, Matt

    1997-01-01

    Funded by the Combat Poverty Agency, this report presented a review and evaluation of the Community Addiction Response Programme (CARP) in Killinarden, Tallaght, in south-west Dublin. The report examined the historical background to the programme and looked at its development as a particular response to the issue of drug misuse in the area. Data were gathered using internal documentation, such as reports, proposals and minutes; semi-structured interviews with staff, team members, professional...

  3. 76 FR 77492 - Draft Guidance on Improving the Process for Preparing Efficient and Timely Environmental Reviews...

    2011-12-13

    ...,563, 76 FR 3821 (January 21, 2011), available at http://www.gpo.gov/fdsys/pkg/FR-2011-01-21/pdf/2011... Regulation and Regulatory Review,'' Exec. Order 13,563, 76 FR 3821 (January 21, 2011), available at http://www.gpo.gov/fdsys/pkg/FR-2011-01-21/pdf/2011-1385.pdf . \\4\\ This guidance is not a rule or...

  4. 78 FR 21618 - Mortgagee Review Board: Administrative Actions

    2013-04-11

    ...] 117. Right Mortgage Company, Lebanon, TN 118. Rokitto Enterprises, Porter Ranch, CA 119. Sacramento..., Probations, Reprimands, and Administrative Payments 1. Academy Mortgage Corporation, Sandy, UT Action: On April 27, 2012, the Board entered into a Settlement Agreement with Academy Mortgage Corporation...

  5. Conducting need-for-power review for nuclear power plants: guidelines to states. Draft report

    The report is intended to describe the state regulatory commissions and other state agencies the standards and criteria used by NRC in conducting need-for-power evaluations for the licensing of nuclear power plants. These are intended as guidelines to states which may wish to perform a need-for-power review that will suffice for adoption by the NRC in its licensing process. Three methodologies which have been used for need-for-power evaluations and which meet NRC standards are included

  6. [Support system to the process of risk assessment in construction company: assessment, drafting, and review].

    Ramenghi, D; Golferini, M

    2012-01-01

    The aim of this study is provide a tool for perrforming risk assessment, a methodology for completing the risk assessment document and a support tool to objectively review the Risk Assessment Document (RAD) in order to its improvement. Starting from a series of documents available such as legislation, literature, best practices, guidelines, and evaluating the documents of 10 construction companies, has been defined list of content needed to RAD. In conclusion, we have implemented a support system organized into chapters that allow the Employer/competent doctor compiling/evaluating the DVR. PMID:23405703

  7. 19 CFR 207.63 - Circulation of draft questionnaires.

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Circulation of draft questionnaires. 207.63... SUBSIDIZED EXPORTS TO THE UNITED STATES Five-Year Reviews § 207.63 Circulation of draft questionnaires. (a) The Director shall circulate draft questionnaires to the parties for comment in each full review....

  8. Peer Review Documents Related to the Evaluation of Benchmark Dose Software (BMDS) (External Review Draft, version 1.1b)

    BMDS is one of the Agency's premier tools for estimating risk assessments, therefore the validity and reliability of its statistical models are of paramount importance. This page provides links to peer review and expert summaries of the BMDS application and its models as they wer...

  9. Review of restrictive actions under the Australian drug regulatory system.

    Dukes, M N; Lunde, I

    1982-05-15

    An analysis of restrictive measures taken by the Australian Drug Evaluation Committee (ADEC) over the period of 27 months (from March, 1976, to June, 1978) was made by two non-Australian observers. During this period, the ADEC took 32 useful restrictive measures (a little more than one a month). The analysis was limited only to cases in which ADEC took substantial action; if less comprehensive measures were included, the number of valid actions to counter the occurrence of iatrogenic complications would be much greater. It is concluded that, although it is an undisputed fact that many pharmaceutical companies maintain the highest ethical standards, there is a need for the type of objective and dispassionate control exercised by the Australian Drug Evaluation Committee. PMID:7099069

  10. 75 FR 9613 - Draft NIJ Restraints Standard for Criminal Justice

    2010-03-03

    ... of Justice Programs Draft NIJ Restraints Standard for Criminal Justice AGENCY: National Institute of Justice, Office of Justice Programs, DOJ. ACTION: Notice of Draft NIJ Restraints Standard for Criminal... Restraints Standard for Criminal Justice'' and (2) a draft companion document entitled, ``NIJ...

  11. 77 FR 69619 - Draft Recommendations of Joint Outreach Team

    2012-11-20

    ... Area Power Administration Draft Recommendations of Joint Outreach Team AGENCY: Western Area Power Administration, DOE. ACTION: Notice of Availability of draft recommendations of Western/DOE Joint Outreach Team... Department of Energy (DOE), is publishing the draft recommendations of the Western/DOE Joint Outreach...

  12. Five-Year Review of CERCLA Response Actions at the Idaho National Laboratory

    W. L. Jolley

    2007-02-01

    This report summarizes the documentation submitted in support of the five-year review or remedial actions implemented under the Comprehensive Environmental Response, Compensation, and Liability Act Sitewide at the Idaho National Laboratory. The report also summarizes documentation and inspections conducted at the no-further-action sites. This review covered actions conducted at 9 of the 10 waste area groups at the Idaho National Laboratory, i.e. Waste Area Groups 1, 2, 3, 4, 5, 6, 7, 9, and 10. Waste Area Group 8 was not subject to this review, because it does not fall under the jurisdiction of the U.S. Department of Energy Idaho Operations Office. The review included past site inspections and monitoring data collected in support of the remedial actions. The remedial actions have been completed at Waste Area Groups 2, 4, 5, 6, and 9. Remedial action reports have been completed for Waste Area Groups 2 and 4, and remedial action reports are expected to be completed during 2005 for Waste Area Groups 1, 5, and 9. Remediation is ongoing at Waste Area Groups 3, 7, and 10. Remedial investigations are yet to be completed for Operable Units 3-14, 7-13/14, and 10-08. The review showed that the remedies have been constructed in accordance with the requirements of the Records of Decision and are functioning as designed. Immediate threats have been addressed, and the remedies continue to be protective. Potential short-term threats are being addressed though institutional controls. Soil cover and cap remedies are being maintained properly and inspected in accordance with the appropriate requirements. Soil removal actions and equipment or system removals have successfully achieved remedial action objectives identified in the Records of Decision. The next Sitewide five-year review is scheduled for completion by 2011.

  13. Implementation Plan for the Hawaii Geothermal Project Environmental Impact Statement (DOE Review Draft:)

    None

    1992-09-18

    The US Department of Energy (DOE) is preparing an Environmental Impact Statement (EIS) that identifies and evaluates the environmental impacts associated with the proposed Hawaii Geothermal Project (HGP), as defined by the State of Hawaii in its 1990 proposal to Congress (DBED 1990). The location of the proposed project is shown in Figure 1.1. The EIS is being prepared pursuant to the requirements of the National Environmental Policy Act of 1969 (NEPA), as implemented by the President's Council on Environmental Quality (CEQ) regulations (40 CFR Parts 1500-1508) and the DOE NEPA Implementing Procedures (10 CFR 1021), effective May 26, 1992. The State's proposal for the four-phase HGP consists of (1) exploration and testing of the geothermal resource beneath the slopes of the active Kilauea volcano on the Island of Hawaii (Big Island), (2) demonstration of deep-water power cable technology in the Alenuihaha Channel between the Big Island and Mau, (3) verification and characterization of the geothermal resource on the Big Island, and (4) construction and operation of commercial geothermal power production facilities on the Big Island, with overland and submarine transmission of electricity from the Big Island to Oahu and possibly other islands. DOE prepared appropriate NEPA documentation for separate federal actions related to Phase 1 and 2 research projects, which have been completed. This EIS will consider Phases 3 and 4, as well as reasonable alternatives to the HGP. Such alternatives include biomass coal, solar photovoltaic, wind energy, and construction and operation of commercial geothermal power production facilities on the Island of Hawaii (for exclusive use on the Big Island). In addition, the EIs will consider the reasonable alternatives among submarine cable technologies, geothermal extraction, production, and power generating technologies; pollution control technologies; overland and submarine power transmission routes; sites reasonably suited to

  14. Design and analysis of field studies with bees: A critical review of the draft EFSA guidance.

    Bakker, Frank

    2016-07-01

    The specific protection goal, primary assessment endpoints, acceptable effect thresholds, and experimental design proposed in the European Food Safety Authority (EFSA) update of the bee guidance document are subjected to critical review. It is concluded that the negligible effect criteria were established without sufficient regulatory definition and without convincing scientific argumentation. For the assessment endpoints, effects on hive strength lack temporal definition and the reduction to numbers of bees is inappropriate to evaluate effects. Restricting mortality assessments to homing failure is not theoretically justified and specific criteria were incorrectly derived. The combination of acute effect estimates with models for chronic stressors is biased risk assessment and a temporal basis for the acceptability of effects is missing. Effects on overwintering success cannot be experimentally assessed using the proposed criteria. The experimental methodology proposed is inappropriate and the logistical consequences, in particular those related to replication and land use are such that field studies are no longer a feasible option for the risk assessment. It may be necessary to explore new lines of thought for the set-up of field studies and to clearly separate experimentation from monitoring. Integr Environ Assess Manag 2016;12:422-428. © 2015 SETAC. PMID:26436642

  15. 24 CFR 597.300 - HUD action and review of nominations for designation.

    2010-04-01

    ... required by § 597.202(b). (c) Evaluation of nominations. In the process of reviewing each nomination... ENTERPRISE COMMUNITIES: ROUND ONE DESIGNATIONS Designation Process § 597.300 HUD action and review of... by this part. HUD will notify the State(s) and local government(s) whether or not the nomination...

  16. 5 CFR 1201.161 - Action by the Equal Employment Opportunity Commission; judicial review.

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Action by the Equal Employment Opportunity Commission; judicial review. 1201.161 Section 1201.161 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND PROCEDURES PRACTICES AND PROCEDURES Procedures for Cases Involving Allegations of Discrimination Review of...

  17. Development and verification for review plan of emergency action level (EAL)

    Emergency action levels (EALs) are used as the trigger in order to implement the precautionary protective actions at the nuclear emergency. In this study the framework for applying the EAL in Japan and the process for developing the review plan, such as procedures to review the basis of EAL submitted by the licensee, have been investigated based on the survey for EAL review executed in the United States. In addition, issues to reflect the EAL framework in enhancement of the local government emergency planning and emergency response support system have been investigated. (author)

  18. 77 FR 76000 - Notice of Availability of Draft Report of the NOAA Research and Development Portfolio Review Task...

    2012-12-26

    ... SAB was also asked to provide advice on an appropriate organizational approach, within NOAA, for support of this R&D portfolio. NOAA welcomes all comments on the content of the draft report. We also request comments on any perceived inconsistencies within the report, and possible omissions of...

  19. IRIS Toxicological Review of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine (Rdx) (Public Comment Draft)

    EPA is developing an Integrated Risk Information System (IRIS) assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) and has released the draft assessment for public comment. When final, the assessment will appear on the IRIS database.

  20. 76 FR 54227 - Draft Toxicological Review of n-Butanol: In Support of Summary Information on the Integrated Risk...

    2011-08-31

    ...) within the EPA Office of Research and Development (ORD). EPA is releasing this draft assessment solely..., contact information, any sponsorship information, whether you will be a speaker or an observer, and if you... Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, NW., Washington, DC...

  1. Reviewing Biosphere Reserves globally: effective conservation action or bureaucratic label?

    Coetzer, Kaera L; Witkowski, Edward T F; Erasmus, Barend F N

    2014-02-01

    The Biosphere Reserve (BR) model of UNESCO's Man and the Biosphere Programme reflects a shift towards more accountable conservation. Biosphere Reserves attempt to reconcile environmental protection with sustainable development; they explicitly acknowledge humans, and human interests in the conservation landscape while still maintaining the ecological values of existing protected areas. Conceptually, this model is attractive, with 610 sites currently designated globally. Yet the practical reality of implementing dual 'conservation' and 'development' goals is challenging, with few examples successfully conforming to the model's full criteria. Here, we review the history of Biosphere Reserves from first inception in 1974 to the current status quo, and examine the suitability of the designation as an effective conservation model. We track the spatial expansion of Biosphere Reserves globally, assessing the influence of the Statutory Framework of the World Network of Biosphere Reserves and Seville strategy in 1995, when the BR concept refocused its core objectives on sustainable development. We use a comprehensive range of case studies to discuss conformity to the Programme, the social and ecological consequences associated with implementation of the designation, and challenges in aligning conservation and development. Given that the 'Biosphere Reserve' label is a relatively unknown designation in the public arena, this review also provides details on popularising the Biosphere Reserve brand, as well as prospects for further research, currently unexploited, but implicit in the designation. PMID:23701641

  2. Drafting Fundamentals. Drafting Module 1. Instructor's Guide.

    Missouri Univ., Columbia. Instructional Materials Lab.

    This Missouri Vocational Instruction Management System instructor's drafting guide has been keyed to the drafting competency profile developed by state industry and education professionals. The guide contains a cross-reference table of instructional materials. Ten units cover drafting fundamentals: (1) introduction to drafting; (2) general safety;…

  3. Implementation of evidence-based practice in nursing using action research: a review

    Munten, Guus; Bogaard, Joop van den; Cox, Karen; Garretsen, Henk; Bongers, Inge

    2010-01-01

    As is often reported in the literature exploring the research-practice gap, applying the principles of evidence-based practice is easier said than done. Action research is a methodology with an explicit intent of linking the worlds of research and practice. This review attempts to answer the questio

  4. 77 FR 8262 - Draft Guidance on Investigational New Drug Applications for Positron Emission Tomography Drugs...

    2012-02-14

    ... Positron Emission Tomography Drugs; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... entitled ``Investigational New Drug Applications for Positron Emission Tomography (PET) Drugs.'' The draft... Applications for Positron Emission Tomography (PET) drugs.'' The draft guidance summarizes the IND process...

  5. 75 FR 41452 - Draft Guidance, “Federal Greenhouse Gas Accounting and Reporting”

    2010-07-16

    ... Leadership in Environmental, Energy, and Economic Performance (74 FR 52117) in order to establish an... QUALITY Draft Guidance, ``Federal Greenhouse Gas Accounting and Reporting'' AGENCY: Council on Environmental Quality. ACTION: Notice of Availability, Draft Guidance, ``Federal Greenhouse Gas Accounting...

  6. EU-stress test: Swiss national action plan. Follow-up of peer review 2012 year-end status report

    NONE

    2012-12-15

    The European Union (EU) stress test is part of the review process which Switzerland initiated immediately after the reactor accident in Japan. As a direct consequence of the accident, the Swiss Federal Nuclear Safety Inspectorate (ENSI) issued three formal orders in which the operators of the Swiss nuclear power plants (NPPs) were required to implement immediate measures and to conduct additional reassessments. The immediate measures comprised the establishment of an external emergency storage facility for the Swiss NPPs, including the necessary plant-specific connections, and back-fittings to provide external injection into the spent fuel pools. The additional reassessments focused on the design of the Swiss NPPs against earthquakes, external flooding and a combination thereof. Investigations on the coolant supply for the safety systems and the spent fuel pool cooling were also requested. ENSI carried out an analysis of the events at Fukushima providing detailed descriptions of the causes, consequences and radiological impacts of the accident. The reports analyse the contributory human and organisational factors, and specify lessons that can be derived from this information. ENSI instructed the Swiss operators to take part in the EU stress test. There was to be particular examination of the robustness of the NPPs in case of impacts beyond the design basis due to earthquakes, external flooding and extreme weather conditions, with consequential loss of power supply and heat sink, and the need for severe accident management actions. ENSI requested further clarification on plant specific issues and produced the National Report which was delivered to the EU Commission. A Country Peer Review Draft Report was drawn up for each country, including a list of issues (open points) for further follow-up by the review team. Eight new open points were identified to further improve the safety of the Swiss NPPs. These open points together with the issues identified in the analysis

  7. EU-stress test: Swiss national action plan. Follow-up of peer review 2012 year-end status report

    The European Union (EU) stress test is part of the review process which Switzerland initiated immediately after the reactor accident in Japan. As a direct consequence of the accident, the Swiss Federal Nuclear Safety Inspectorate (ENSI) issued three formal orders in which the operators of the Swiss nuclear power plants (NPPs) were required to implement immediate measures and to conduct additional reassessments. The immediate measures comprised the establishment of an external emergency storage facility for the Swiss NPPs, including the necessary plant-specific connections, and back-fittings to provide external injection into the spent fuel pools. The additional reassessments focused on the design of the Swiss NPPs against earthquakes, external flooding and a combination thereof. Investigations on the coolant supply for the safety systems and the spent fuel pool cooling were also requested. ENSI carried out an analysis of the events at Fukushima providing detailed descriptions of the causes, consequences and radiological impacts of the accident. The reports analyse the contributory human and organisational factors, and specify lessons that can be derived from this information. ENSI instructed the Swiss operators to take part in the EU stress test. There was to be particular examination of the robustness of the NPPs in case of impacts beyond the design basis due to earthquakes, external flooding and extreme weather conditions, with consequential loss of power supply and heat sink, and the need for severe accident management actions. ENSI requested further clarification on plant specific issues and produced the National Report which was delivered to the EU Commission. A Country Peer Review Draft Report was drawn up for each country, including a list of issues (open points) for further follow-up by the review team. Eight new open points were identified to further improve the safety of the Swiss NPPs. These open points together with the issues identified in the analysis

  8. Peer-review study of the draft handbook for human-reliability analysis with emphasis on nuclear-power-plant applications, NUREG/CR-1278

    This report describes a peer review of the draft Handbook for Human Reliability Analysis with Emphasis on Nuclear Power Plant Applications, NUREG/CR-1278. The purpose of the study was to determine to what extent peers agree with the human behavior models and estimates of human error probabilities (HEPs) contained in the Handbook. Twenty-nine human factors experts participated in the study. Twenty of the participants were Americans; nine were from other countries. The peers performed human reliability analyses of a variety of human performance scenarios describing operator activities in nuclear power plant settings. They also answered questionnaires pertaining to the contents and application of the Handbook. An analysis of peer solutions to the human reliability analysis problems and peer responses to the questionnaire was performed. Recommendations regarding the format and contents of the Handbook were developed from the study findings

  9. 75 FR 80496 - Registration Review; Pesticide Dockets Opened for Review and Comment and Other Docket Actions

    2010-12-22

    ...), lindane, oleic acid sulfonates, potassium permanganate, and zinc silicate. These pesticides do not...)ethylamine, lindane, oleic acid sulfonates, potassium permanganate, and zinc silicate because these... for registration review. The revised work plan has removed a leaching/ migration...

  10. Combined action of pesticides towards aquatic organisms; a review of available literature from 1972-1998

    Deneer, J.W.

    2000-01-01

    Literature from 1972 to 1998 was critically reviewed and used to assess to what degree the concept of concentration addition can correctly predict the acute toxicity of mixtures of pesticides towards aquatic organisms. For more than 90% of 202 mixtures in 26 studies concentration addition predicted the observed toxicity within a factor of 2. There were no apparent differences between mixtures of compounds with similar or dissimilar toxic modes of action. Deviations from concentration addition...

  11. 45 CFR 2540.640 - When will the reviewing official make a decision on the proposed action?

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false When will the reviewing official make a decision... or Misleading Statements § 2540.640 When will the reviewing official make a decision on the proposed action? The reviewing official will issue a decision within 45 days of receipt of your response....

  12. 45 CFR 60.10 - Reporting negative actions or findings taken by peer review organizations or private...

    2010-10-01

    ... peer review organizations or private accreditation entities. 60.10 Section 60.10 Public Welfare... negative actions or findings taken by peer review organizations or private accreditation entities. (a) What..., dentist, or entity by a peer review organization or private accreditation entity. The health...

  13. Radiological health review of the Draft Environmental Impact Statement (DOE/EIS-0026-D) Waste Isolation Pilot Plant, US Department of Energy. Report EEG-3

    This review of radiological health considerations contains a number of concerns, questions and recommendations that should be addressed by the Department of Energy in the final Environmental Impact Statement (EIS) for the Waste Isolation Pilot Plant (WIPP). Using the assumptions contained in the Draft Environmental Impact Statement (DEIS), the Environmental Evaluation Group (EEG) calculated a number of radiation doses and the results were found to be in general agreement with those presented in the DEIS. The doses resulting from the operational and long-range releases from WIPP to the general population are no more than a fraction of existing radiation doses to the public. However, there are a number of technical considerations in the assessment of radiation exposure that were not adequately evaluated in the DEIS. They are discussed in this review. A number of additional dosage estimates have been identified that need to be calculated by both DOE and EEG. As the DEIS did not contain estimates of the amounts of radioactivity to be permanently located in the repository, it was necessary to calculate these amounts. Health effects, transportation, waste acceptance criteria, site evaluation, site selection criteria, operational exposure, the experimental waste program, long term radiation releases, retrievability, and decommissioning are the categories of the DEIS which were evaluated

  14. 78 FR 70047 - Request for the Technical Review of 25 Draft Skin Notation Assignments and Skin Notation Profiles

    2013-11-22

    ... Skin Notation Assignments and Skin Notation Profiles AGENCY: National Institute for Occupational Safety... Human Services (HHS). ACTION: Request for comments. SUMMARY: The National Institute for Occupational..., such as airway hyper reactivity (asthma). Candidate chemicals may be assigned more than one...

  15. 76 FR 72725 - Draft License Renewal Interim Staff Guidance LR-ISG-2011-05: Ongoing Review of Operating Experience

    2011-11-25

    ... Guidance (LR-ISG), LR-ISG-2011-05, ``Ongoing Review of Operating Experience.'' This LR-ISG provides... on how the ongoing review of operating experience should be used to ensure the effectiveness of the... their programmatic activities for operating experience reviews are appropriate for considering...

  16. ICLUS Tools and Datasets (Version 1.2) and User's Manual: Arcgis Tools and Datasets for Modeling US Housing Density (External Review Draft)

    This draft Geographic Information System (GIS) tool can be used to generate scenarios of housing-density changes and calculate impervious surface cover for the conterminous United States. A draft User’s Guide accompanies the tool. This product distributes the population project...

  17. Draft audit report, human factors engineering control room design review: Saint Lucie Nuclear Power Plant, Unit No. 2

    A human factors engineering preliminary design review of the Saint Lucie Unit 2 control room was performed at the site on August 3 through August 7, 1981. This design review was carried out by a team from the Human Factors Engineering Branch, Division of Human Factors Safety. This report was prepared on the basis of the HFEB's review of the applicant's Preliminary Design Assessment and the human factors engineering design review/audit performed at the site. The review team included human factors consultants from BioTechnology, Inc., Falls Church, Virginia, and from Lawrence Livermore National Laboratory (University of California), Livermore, California

  18. 76 FR 174 - NIJ Draft Metal Detector Standards for Public Safety

    2011-01-03

    ... of Justice Programs NIJ Draft Metal Detector Standards for Public Safety AGENCY: National Institute of Justice. ACTION: Notice and request for comments on the Draft Metal Detector Standards for Public... the following draft standards for metal detectors: 1. Walk-through Metal Detector Standard for...

  19. A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin

    Gaurang P Mavani

    2015-03-01

    Full Text Available The pressor and antidiuretic actions of arginine vasopressin (AVP have been well documented. This review focuses on the less widely appreciated actions of AVP which also have important physiologic functions and when better understood may provide important insights into common disease states. These actions include effects on pain perception and bone structure as well as important relationships to the varied components of metabolic syndrome. These include effects on blood glucose, lipid levels, and blood pressure. AVP may also play a role in the progression of chronic kidney disease and effect physiologic changes relating to aging, abnormal social behavior and cognitive function. Important cellular responses including cell proliferation, inflammation and control of infection and their relationship to AVP are described. Finally, the effects of AVP on hemostasis and the hypothalamic-pituitary-adrenal access are noted. The goal of this summary of the various actions of AVP is to direct attention to the potential benefits of research in these underemphasized areas of importance.

  20. 75 FR 13599 - Draft Regulatory Guide: Issuance, Availability

    2010-03-22

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of issuance and availability of Draft Regulatory Guide, DG-8040, ``Health Physics Surveys During Enriched Uranium-235 Processing and...

  1. 75 FR 35508 - Draft Regulatory Guide: Issuance, Availability

    2010-06-22

    ... COMMISSION Draft Regulatory Guide: Issuance, Availability AGENCY: Nuclear Regulatory Commission. ACTION: Notice of Issuance and Availability of Draft Regulatory Guide, DG-1249, ``Criteria for Use of Computers... CFR Part 73, ``Physical Protection of Plants and Materials,'' regarding the security of digital...

  2. Actions, topological terms and boundaries in first order gravity: A review

    Corichi, Alejandro; Vukasinac, Tatjana

    2016-01-01

    In this review we consider first order gravity in four dimensions. In particular, we focus our attention in formulations where the fundamental variables are a tetrad $e_a^I$ and a SO(3,1) connection ${\\omega_{aI}}^J$. We study the most general action principle compatible with diffeomorphism invariance. This implies, in particular, considering besides the standard Einstein-Hilbert-Palatini term, other terms that either do not change the equations of motion, or are topological in nature. Having a well defined action principle sometimes involves the need for additional boundary terms, whose detailed form may depend on the particular boundary conditions at hand. In this work, we consider spacetimes that include a boundary at infinity, satisfying asymptotically flat boundary conditions and/or an internal boundary satisfying isolated horizons boundary conditions. We focus on the covariant Hamiltonian formalism where the phase space $\\Gamma$ is given by solutions to the equations of motion. For each of the possible ...

  3. 75 FR 57776 - Clean Water Act Section 303(d): Notice for the Public Review of the Draft Total Maximum Daily...

    2010-09-22

    ... and actions that together ensure that pollution controls needed to restore Bay water quality are.... Thursday, October 7, 2010: VA Watershed meeting from 6 to 8 p.m. at the Crowne Plaza Hampton Marina Hotel... and other pollution controls required by the CWA are not stringent enough to attain or maintain...

  4. Streamlined Approach for Environmental Restoration (SAFER) Plan for Corrective Action Unit 124: Storage Tanks, Nevada Test Site, Nevada (Draft), Revision 0

    Alfred Wickline

    2007-04-01

    This Streamlined Approach for Environmental Restoration (SAFER) Plan addresses closure for Corrective Action Unit (CAU) 124, Areas 8, 15, and 16 Storage Tanks, identified in the Federal Facility Agreement and Consent Order. Corrective Action Unit 124 consists of five Corrective Action Sites (CASs) located in Areas 8, 15, and 16 of the Nevada Test Site as follows: • 08-02-01, Underground Storage Tank • 15-02-01, Irrigation Piping • 16-02-03, Underground Storage Tank • 16-02-04, Fuel Oil Piping • 16-99-04, Fuel Line (Buried) and UST This plan provides the methodology of field activities necessary to gather information to close each CAS. There is sufficient information and process knowledge from historical documentation and investigations of similar sites regarding the expected nature and extent of potential contaminants to recommend closure of CAU 124 using the SAFER process.

  5. A review on alcohol: from the central action mechanism to chemical dependency

    João Victor Vezali Costardi

    2015-08-01

    Full Text Available SummaryIntroduction:alcohol is a psychotropic depressant of the central nervous system (CNS that promotes simultaneous changes in several neuronal pathways, exerting a profound neurological impact that leads to various behavioral and biological alterations.Objectives:to describe the effects of alcohol on the CNS, identifying the signaling pathways that are modified and the biological effects resulting from its consumption.Methods:a literature review was conducted and articles published in different languages over the last 15 years were retrieved.Results:the studies reviewed describe the direct effect of alcohol on several neurotransmitter receptors (gamma-aminobutyric acid [GABA], glutamate, endocannabinoids AEA and 2-AG, among others, the indirect effect of alcohol on the limbic and opioid systems, and the effect on calcium and potassium channels and on proteins regulated by GABA in the hippocampus.Discussion and conclusion:the multiple actions of alcohol on the CNS result in a general effect of psychomotor depression, difficulties in information storage and logical reasoning and motor incoordination, in addition to stimulating the reward system, a fact that may explain the development of addiction. Knowledge on the neuronal signaling pathways that are altered by alcohol allows the identification of effectors which could reduce its central action, thus, offering new therapeutic perspectives for the rehabilitation of alcohol addicts.

  6. Treatments and technologies in the rehabilitation of apraxia and action disorganisation syndrome: A review

    Worthington, Andrew

    2016-01-01

    BACKGROUND: Apraxia and Action Disorganisation Syndrome are characterised by an inability to use tools and carry out ordered sequences of movements in the absence of motor or sensory impairment. To date treatment for these complex but debilitating conditions has received little attention. OBJECTIVES: To provide an overview of apraxia and action disorganisation syndrome and its treatment, providing a state of the art summary for practitioners including likely future therapeutic directions. METHOD: Review of apraxia literature and treatment studies collated from internet searches involving MEDLINE, PubMed, PyscINFO and Google Scholar as well as the author’s own catalogue. RESULTS: Evidence for current restitution and compensatory approaches is critically reviewed, with limited evidence to date in support of either method. Strategy training is the most promising intervention type with no support for sensory and exploratory interventions, practice effects only for direct task-specific training, and modest support for gestural training. CONCLUSIONS: Larger controlled studies are needed but evidence is sufficient to indicate certain approaches over others. Advances in assistive technology have not translated into mainstream therapy but future interventions are likely to require a model-based approach which embraces current technologies in order to provide a more accessible, effective and cost-efficient approach to rehabilitation. PMID:27314872

  7. Exploring the relationship between faculty, students, and the Social and Behavioral Ethics Review Committee through action research.

    Griebling, Susan; Zayas, Vilma Reyes; Borders, Christy; Moore, Elizabeth; Sokol, Ashley; Brydon-Miller, Mary; Gerlach, Julie; Norman, Claudia

    2009-06-01

    STUDENT RESEARCHERS USED ACTION research both to study the relationship between university researchers and the ethics committee, and also to explore the ethics committee's approach to protocols involving action research and other qualitative methods. We review the existing literature on relationships between university faculty and their ethics committees and briefly discuss the basic tenets of action research. We then describe our research process and the specific recommendations that resulted from this work. Finally, we consider the ways in which action research can be used to better understand and address institutional problems through effective collaboration and dialogue. PMID:19480589

  8. The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research

    Hui Wang

    2014-01-01

    Full Text Available Rhizoma Coptidis (Huang Lian in Chinese pinyin is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions.

  9. Developing Low Carbon Transport Policies in Peru - Draft Transport NAMA

    Ramirez Brinez, C. P.; Tyler, N.

    2012-01-01

    The report is an initial draft of a Transport NAMA for Peru. NAMA stands for Nationally Appropriate Mitigation Actions and are a relatively new initiative from the UNFCCC to tackle climate change. The report covers

  10. Radioactive waste isolation in salt: Peer review of the Office of Nuclear Waste Isolation's draft report on an issues hierarchy and data needs for site characterization

    Harrison, W.; Fenster, D.F.; Ditmars, J.D.; Paddock, R.A.; Rote, D.M.; Hambley, D.F.; Seitz, M.G.; Hull, A.B.

    1986-12-01

    At the request of the Salt Repository Project (SRPO), Argonne National Laboratory conducted an independent peer review of a report by the Battelle Office of Nuclear Waste Isolation entitled ''Salt Repository Project Issues Hierarchy and Data Needs for Site Characterization (Draft).'' This report provided a logical structure for evaluating the outstanding questions (issues) related to selection and licensing of a site as a high-level waste repository. It also provided a first estimate of the information and data necessary to answer or resolve those questions. As such, this report is the first step in developing a strategy for site characterization. Microfiche copies of ''Draft Issues Hierarchy, Resolution Strategy, and Information Needs for Site Characterization and Environmental/Socioeconomic Evaluation - July, 1986'' and ''Issues Hierarchy and Data Needs for Site Characterization - February, 1985'' are included in the back pocket of this report.

  11. Actions, topological terms and boundaries in first-order gravity: A review

    Corichi, Alejandro; Rubalcava-García, Irais; Vukašinac, Tatjana

    2016-03-01

    In this review, we consider first-order gravity in four dimensions. In particular, we focus our attention in formulations where the fundamental variables are a tetrad eaI and a SO(3, 1) connection ωaIJ. We study the most general action principle compatible with diffeomorphism invariance. This implies, in particular, considering besides the standard Einstein-Hilbert-Palatini term, other terms that either do not change the equations of motion, or are topological in nature. Having a well defined action principle sometimes involves the need for additional boundary terms, whose detailed form may depend on the particular boundary conditions at hand. In this work, we consider spacetimes that include a boundary at infinity, satisfying asymptotically flat boundary conditions and/or an internal boundary satisfying isolated horizons boundary conditions. We focus on the covariant Hamiltonian formalism where the phase space Γ is given by solutions to the equations of motion. For each of the possible terms contributing to the action, we consider the well-posedness of the action, its finiteness, the contribution to the symplectic structure, and the Hamiltonian and Noether charges. For the chosen boundary conditions, standard boundary terms warrant a well posed theory. Furthermore, the boundary and topological terms do not contribute to the symplectic structure, nor the Hamiltonian conserved charges. The Noether conserved charges, on the other hand, do depend on such additional terms. The aim of this manuscript is to present a comprehensive and self-contained treatment of the subject, so the style is somewhat pedagogical. Furthermore, along the way, we point out and clarify some issues that have not been clearly understood in the literature.

  12. ERG review of ''draft test plan for in situ testing in an exploratory shaft in salt - March 1985''

    The Engineering Review Group (ERG) was established by the Office of Nuclear Waste Isolation (ONWI) to help evaluate engineering-related issues in the US Department of Energy's nuclear waste repository program. The May 1985 meeting of the ERG reviewed the proposed program which constitutes part of the overall effort to determine site suitability, provide data for repository design and performance assessment, and prepare licensing documentation for radioactive waste disposal in salt. This report documents the ERG's comments and recommendations on these subjects and the ONWI response, prepared by Golder Associates, Inc., to the specific points raised by the ERG

  13. 78 FR 15012 - Request for Nominations of Experts for a Science Advisory Board Panel To Review EPA's Draft...

    2013-03-08

    ... men of all racial and ethnic groups. The EPA SAB Staff Office will acknowledge receipt of nominations... a balanced review panel includes candidates who possess the necessary domains of knowledge, the... expertise, knowledge, and experience (primary factors); (b) availability and willingness to serve;...

  14. Development of a Relative Potency Factor (Rpf) Approach for Polycyclic Aromatic Hydrocarbon (PAH) Mixtures (External Review Draft)

    EPA is conducting a peer review and public comment of the scientific basis supporting the human health hazard and dose-response assessment of polycyclic aromatic hydrocarbon (PAH) mixtures that when finalized will appear on the Integrated Risk Information System (IRIS) database. ...

  15. 75 FR 1617 - Draft Toxicological Review of Methanol: In Support of the Summary Information in the Integrated...

    2010-01-12

    ... Office of Research and Development (ORD). The public comment period and the EPA Science Advisory Board... peer review under applicable information quality guidelines. This document has not been formally... separate processes that provide opportunities for all interested parties to comment on the document....

  16. 78 FR 36767 - Red River Hydro LLC; Notice of Availability of Draft Environmental Assessment

    2013-06-19

    ..., 52 FR 47897), the Office of Energy Projects has reviewed Red River Hydro LLC's application for an... Energy Regulatory Commission Red River Hydro LLC; Notice of Availability of Draft Environmental... prepared a draft environmental assessment (draft EA). The project would be located on the Red River...

  17. Effects of berberine in the gastrointestinal tract - a review of actions and therapeutic implications.

    Chen, Chunqiu; Yu, Zhen; Li, Yongyu; Fichna, Jakub; Storr, Martin

    2014-01-01

    Berberine is an isoquinoline alkaloid present in several plant species, including Coptis sp. and Berberis sp. In traditional medicine, extracts of berberine are used in the treatment of diarrhea of different origins. Recent studies have shown that berberine and its derivatives have significant biological effects on gastrointestinal (GI) and other functions and may become therapeutics for the treatment of diarrhea, gastroenteritis, diabetes, hyperlipidemia, cardiovascular diseases and inflammatory conditions. This paper summarizes the current knowledge on the actions of berberine in the GI tract. Binding and target sites, activated intracellular pathways, as well as the absorption and metabolism of berberine are discussed. Effects that may be useful in future clinical treatment, like antidiarrheal, anti-inflammatory and antitumor effects are critically reviewed and potential clinical applications are presented in detail. PMID:25183302

  18. Herbal Remedies for Coccidiosis Control: A Review of Plants, Compounds, and Anticoccidial Actions

    Thangarasu Muthamilselvan

    2016-01-01

    Full Text Available Coccidiosis is the bane of the poultry industry causing considerable economic loss. Eimeria species are known as protozoan parasites to cause morbidity and death in poultry. In addition to anticoccidial chemicals and vaccines, natural products are emerging as an alternative and complementary way to control avian coccidiosis. In this review, we update recent advances in the use of anticoccidial phytoextracts and phytocompounds, which cover 32 plants and 40 phytocompounds, following a database search in PubMed, Web of Science, and Google Scholar. Four plant products commercially available for coccidiosis are included and discussed. We also highlight the chemical and biological properties of the plants and compounds as related to coccidiosis control. Emphasis is placed on the modes of action of the anticoccidial plants and compounds such as interference with the life cycle of Eimeria, regulation of host immunity to Eimeria, growth regulation of gut bacteria, and/or multiple mechanisms. Biological actions, mechanisms, and prophylactic/therapeutic potential of the compounds and extracts of plant origin in coccidiosis are summarized and discussed.

  19. Viral inactivation in hemotherapy: systematic review on inactivators with action on nucleic acids

    Patricia Marial Sobral

    2012-01-01

    Full Text Available The aim of this study was to conduct a systematic review on the photoinactivators used in hemotherapy, with action on viral genomes. The SciELO, Science Direct, PubMed and Lilacs databases were searched for articles. The inclusion criterion was that these should be articles on inactivators with action on genetic material that had been published between 2000 and 2010. The key words used in identifying such articles were "hemovigilance", "viral inactivation", "photodynamics", "chemoprevention" and "transfusion safety". Twenty-four articles on viral photoinactivation were found with the main photoinactivators covered being: methylene blue, amotosalen HCl, S-303 frangible anchor linker effector (FRALE, riboflavin and inactin. The results showed that methylene blue has currently been studied least, because it diminishes coagulation factors and fibrinogen. Riboflavin has been studied most because it is a photoinactivator of endogenous origin and has few collateral effects. Amotosalen HCl is effective for platelets and is also used on plasma, but may cause changes both to plasma and to platelets, although these are not significant for hemostasis. S-303 FRALE may lead to neoantigens in erythrocytes and is less indicated for red-cell treatment; in such cases, PEN 110 is recommended. Thus, none of the methods for pathogen reduction is effective for all classes of agents and for all blood components, but despite the high cost, these photoinactivators may diminish the risk of blood-transmitted diseases.

  20. A review of ideomotor approaches to perception, cognition, action, and language: advancing a cultural recycling hypothesis.

    Badets, Arnaud; Koch, Iring; Philipp, Andrea M

    2016-01-01

    The term "cultural recycling" derives from the neuronal recycling hypothesis, which suggests that representations of cultural inventions like written words, Arabic numbers, or tools can occupy brain areas dedicated to other functions. In the present selective review article, we propose a recycling hypothesis for the ideomotor mechanism. The ideomotor approach assumes that motor actions are controlled by the anticipation of the expected perceptual consequences that they aim to generate in the environment. Arguably, such action-perception mechanisms contribute to motor behaviour for human and non-human animals since millions of years. However, recent empirical studies suggest that the ideomotor mechanism can also contribute to word processing, number representation, and arithmetic. For instance, it has been shown that the anticipatory simulation of abstract semantics, like the numerical quantitative value of three items can prime processing of the associated Arabic number "3". Arabic numbers, words, or tools represent cultural inventions, so that, from a theoretical perspective, we suggest an ideomotor recycling hypothesis for the interaction with such artefacts. In this view, the ideomotor mechanism spreads its influence to other functions beyond motor control, and is recycled to flexibly adapt different human behaviours towards dealing with more abstract concepts. PMID:25535019

  1. Board-invited review: Estrogen and progesterone signaling: genomic and nongenomic actions in domestic ruminants.

    Stormshak, F; Bishop, C V

    2008-02-01

    Progesterone and estrogens play key roles in regulating various physiological phenomena related to normal growth, development, and reproduction of domestic animals. This review focuses on the mechanisms by which progesterone and estrogens regulate the reproductive processes in these animals. The majority of research on the actions of progesterone and estrogens on the reproductive systems of cattle, sheep, and pigs has been genomic in nature and represents attempts to better understand how these steroids regulate gene expression. Results of recent research suggest that progesterone and estrogens can alter target cell responses nongenomically via membrane receptors. The characteristics of membrane receptors for progesterone and estrogen in various cell types are described and the intracellular signal pathways defined. Estrogens acting via membrane receptors can suppress LH secretion by gonadotropes and stimulate rapid increases in uterine blood flow. Progesterone acting via a membrane receptor has been shown to inhibit binding of oxytocin to oxytocin receptors in isolated endometrial plasma membranes and stimulate capacitation of spermatozoa. Results of research suggest that progesterone and estrogens can act nongenomically to alter target cell responses in domestic animals. The biological implications of this mode of action in these animals are discussed. PMID:17965328

  2. Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review

    F. Bafort

    2014-01-01

    Full Text Available Lactoperoxidase is a member of the family of the mammalian heme peroxidases which have a broad spectrum of activity. Their best known effect is their antimicrobial activity that arouses much interest in in vivo and in vitro applications. In this context, the proper use of lactoperoxidase needs a good understanding of its mode of action, of the factors that favor or limit its activity, and of the features and properties of the active molecules. The first part of this review describes briefly the classification of mammalian peroxidases and their role in the human immune system and in host cell damage. The second part summarizes present knowledge on the mode of action of lactoperoxidase, with special focus on the characteristics to be taken into account for in vitro or in vivo antimicrobial use. The last part looks upon the characteristics of the active molecule produced by lactoperoxidase in the presence of thiocyanate and/or iodide with implication(s on its antimicrobial activity.

  3. The Composition and Biologic Actions of Mineral Trioxide Aggregate: A Review

    Toptancı İR et al.

    2013-06-01

    Full Text Available Aim: Mineral Trioxide Aggregate (MTA is widely used in clinical application such as pulp capping, perforation repair, root-end sealing, canal filling at internal and external root resorption and pulpotomies in primary and permanent teeth. In endodontic field when using a material such as MTA the interaction between material and periapical tissue is so important for healing and life time of endodontic therapy. Although it is sealing ability, the interaction with cells or tissues and their replay to this material play major role for endodontic success. Methods: Literature review was performed using electronic and hand-searching methods for the clinical applications, experimental studies and cellular studies of MTA between 2000 and 2010. Results: MTA is a bioactive material when using vital pulpotomies, apical barrier formation for necrotic pulps and open apices. Numerous study and case reports show MTA is more effective material than other materials in these cases. Many studies have shown the effects of MTA on cementoblasts and odontoblasts. Conclusion: This review shows its composition, biologic action when used different endodontic procedure and interaction between cell and tissues.

  4. Development of a mental health action checklist for improving workplace environment as means of job stress prevention.

    Yoshikawa, Toru; Kawakami, Norito; Kogi, Kazutaka; Tsutsumi, Akizumi; Shimazu, Miyuki; Nagami, Makiko; Shimazu, Akihito

    2007-07-01

    An action checklist for improving the workplace environment by means of enhancing mental health of workers (Mental Health Action Check List: MHACL) was developed. The use of the checklist for primary prevention was examined. MHACL was developed through three steps: (1) Review of related references and collection of improvement examples for designing a draft MHACL; (2) pilot application of the draft at industrial workplaces and trials at workshops of occupational health staff; and (3) proposing a new MHACL for general use in industry. Workplace improvement actions related to mental health were listed in eight technical areas. From 84 workplaces in Japan, 201 such actions were collected. Typical improvement action phrases were extracted based on these examples, and a draft MHACL containing 40 generally applicable actions were prepared. This draft was applied to selected workplaces for its use as a tool for group discussion. Then, the utility of the checklist was discussed by 105 occupational health staff working in public service offices. The workshop suggested modifications of the draft MHACL including improved check items and usage procedures and the need to use easy-to-understand actions. The final version of the MHACL comprised 30 items in six technical areas: A) sharing work planning, B) work time and organization, C) ergonomic work methods, D) workplace environment, E) mutual support in the workplace, and F) preparedness and care. A new action checklist was proposed for use as a means of changing existing workplace environments and proposing practical actions for improving it. The checklist was confirmed to be useful for organizing workplace-level discussion for identifying immediate improvements at the workplace. The checklist is expected to be widely applied for promoting primary prevention measures in terms of better mental health. PMID:17721060

  5. 76 FR 55391 - Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental Effects of...

    2011-09-07

    ... announced on August 17, 2011 (76 FR 51034). Information about rescheduling the release of the draft... HUMAN SERVICES Notice of Postponement of Release of Draft NTP Monograph on Potential Developmental... (NIEHS), National Institutes of Health. ACTION: Notice of postponement of draft NTP monograph and...

  6. 76 FR 9590 - Fisheries and Habitat Conservation and Migratory Birds Programs; Draft Land-Based Wind Energy...

    2011-02-18

    ...; Draft Land-Based Wind Energy Guidelines AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of... comment of draft Wind Energy Guidelines (Guidelines). These draft Guidelines are intended to supersede the... intended to respond to accelerated development of land-based, wind energy generation projects in the...

  7. A Review of Training Methods and Instructional Techniques: Implications for Behavioral Skills Training in U.S. Astronauts (DRAFT)

    Hysong, Sylvia J.; Galarza, Laura; Holland, Albert W.

    2007-01-01

    Long-duration space missions (LDM) place unique physical, environmental and psychological demands on crewmembers that directly affect their ability to live and work in space. A growing body of research on crews working for extended periods in isolated, confined environments reveals the existence of psychological and performance problems in varying degrees of magnitude. The research has also demonstrated that although the environment plays a cathartic role, many of these problems are due to interpersonal frictions (Wood, Lugg, Hysong, & Harm, 1999), and affect each individual differently. Consequently, crewmembers often turn to maladaptive behaviors as coping mechanisms, resulting in decreased productivity and psychological discomfort. From this body of research, critical skills have been identified that can help a crewmember better navigate the psychological challenges of long duration space flight. Although most people lack several of these skills, most of them can be learned; thus, a training program can be designed to teach crewmembers effective leadership, teamwork, and self-care strategies that will help minimize the emergence of maladaptive behaviors. Thus, it is the purpose of this report is twofold: 1) To review the training literature to help determine the optimal instructional methods to use in delivering psychological skill training to the U.S. Astronaut Expedition Corps, and 2) To detail the structure and content of the proposed Astronaut Expedition Corps Psychological Training Program.

  8. Potential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review.

    du Jardin, Kristian Gaarn; Müller, Heidi Kaastrup; Elfving, Betina; Dale, Elena; Wegener, Gregers; Sanchez, Connie

    2016-11-01

    A single i.v. infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor antagonist, may alleviate depressive symptoms within hours of administration in treatment resistant depressed patients, and the antidepressant effect may last for several weeks. These unique therapeutic properties have prompted researchers to explore the mechanisms mediating the antidepressant effects of ketamine, but despite many efforts, no consensus on its antidepressant mechanism of action has been reached. Recent preclinical reports have associated the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) with the antidepressant-like action of ketamine. Here, we review the current evidence for a serotonergic role in ketamine's antidepressant effects. The pharmacological profile of ketamine may include equipotent activity on several non-NMDA targets, and the current hypotheses for the mechanisms responsible for ketamine's antidepressant activity do not appear to preclude the possibility that non-glutamate neurotransmitters are involved in the antidepressant effects. At multiple levels, the serotonergic and glutamatergic systems interact, and such crosstalk could support the notion that changes in serotonergic neurotransmission may impact ketamine's antidepressant potential. In line with these prospects, ketamine may increase 5-HT levels in the prefrontal cortex of rats, plausibly via hippocampal NMDA receptor inhibition and activation of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. In addition, a number of preclinical studies suggest that the antidepressant-like effects of ketamine may depend on endogenous activation of 5-HT receptors. Recent imaging and behavioral data predominantly support a role for 5-HT1A or 5-HT1B receptors, but the full range of 5-HT receptors has currently not been systematically investigated in this context. Furthermore, the nature of any 5-HT dependent mechanism in ketamine's antidepressant effect is currently not

  9. INHIBITION OF THE SODIUM-IODIDE SYMPORTER BY PERCHLORATE: AN EVALUATION OF LIFESTAGE SENSITIVITY USING PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELING (EXTERNAL REVIEW DRAFT)

    EPA first released this document in draft form as supporting material for the Preliminary Regulatory Determination on Perchlorate (FR Notice) in October 2008. The document has since been revised. The final report is available in response to comments from independent external pee...

  10. Human-factors control-room-design review draft audit report: Detroit Edison Company, Enrico Fermi Atomic Power Plant--Unit 2

    A human factors audit of the Fermi-2 control room was conducted April 27 through May 1, 1981. This report contains the audit team findings, organized according to the draft NUREG-0700 guidelines sections. The discrepancies identified during the audit are categorized according to their severity and the required schedule for their resolution

  11. 78 FR 78366 - Draft Generic Drug User Fee Act Information Technology Plan; Availability for Comment

    2013-12-26

    ...-based environment that enhances the regulatory review process for human pharmaceuticals. DATES: Submit... approvals, drug supply chain, and other topics related to human pharmaceuticals. The draft GDUFA IT...

  12. Action Research, Assessment, and Institutional Review Boards (IRB): Conflicting Demands or Productive Tension for the Academic Librarian?

    Farrell, Robert

    2014-01-01

    This article puts forward an "assessment/action research/publication" cycle that integrates aspects of the assessment, research, and Institutional Review Board (IRB) processes to provide academic librarians with a systematic approach for balancing competing workplace demands and give library managers a roadmap for creating a…

  13. Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers

    T. Dörner; N. Kinnman; P.P. Tak

    2010-01-01

    B cell-depletion therapy, particularly using anti-CD20 treatment, has provided proof of concept that targeting B cells and the humoral response may result in clinical improvements in immune-mediated inflammatory disease. In this review, the mechanisms of action of B cell-targeting drugs are investig

  14. Insights into Attempts at Using Action Research in a Collaborative Work in a Policy Review Exercise in Botswana

    Koosimile, Anthony Tsatsing

    2011-01-01

    In this paper I embrace the thinking that writing on one's experiences in the use of qualitative educational research strategies and principles could potentially contribute to furthering knowledge in the field. In adopting an action research framework to guide collaborative work in a policy review exercise in Botswana, I found that collaborative…

  15. Review of Indigenous Health Curriculum in Nutrition and Dietetics at One Australian University: An Action Research Study

    Wilson, Annabelle M.; Mehta, Kaye; Miller, Jacqueline; Yaxley, Alison; Thomas, Jolene; Jackson, Kathryn; Wray, Amanda; Miller, Michelle D.

    2015-01-01

    This article describes a review undertaken in 2012-2013 by Nutrition and Dietetics, Flinders University, to assess the Indigenous health curriculum of the Bachelor of Nutrition and Dietetics (BND) and Masters of Nutrition and Dietetics (MND). An action research framework was used to guide and inform inquiry. This involved four stages, each of…

  16. IAEA OSART/EXPERT follow-up review mission completes assessment of actions taken by Paks Nuclear Power Plant

    On 28 February 2004 the IAEA completed its follow-up review mission to assess the actions taken by Paks nuclear power plant (NPP) in response to the Agency's recommendations and suggestions made during the 2001 Operational Safety Review Team (OSART) mission and the 2003 Expert mission that investigated the fuel cleaning incident at the Paks NPP in Hungary. The mission was requested by the Hungarian Government to provide an independent assessment of the actions taken by Paks NPP. The IAEA team determined that the actions taken by Paks have resulted in tangible progress and concluded that all issues were either fully resolved or progressing satisfactorily. In a press conference, the team's conclusions in five areas were highlighted: management, Regulatory Oversight/Interface, operations and maintenance, including operating experience, radiation protection, emergency planning and preparedness, and transparency

  17. Les impacts de la révision collaborative étayée : une recherche-action en didactique de la production écrite en français langue étrangère.

    Do, Thi Bich Thuy

    2011-01-01

    This action-research aims to measure the effects of a trained peer review experiment in L2 writing instruction. A classroom-based study on peer review training was conducted during one semester with 22 Vietnamese students in a writing class. In the experimental group, the drafts were revised by pair with a peer review checklist questions, then rewritten and corrected by the teacher. In the control group, the drafts were written once and corrected by the teacher. Text and feedbacks corpus, pai...

  18. Legal contract drafting support

    Pace, Gordon; Duca, Edward

    2012-01-01

    The notary drafts the contract on her computer – fixing a highlighted typo, ignoring the complex grammar warning. More worrying is the clause highlighted with an explanation of how it conflicts with another contract her client has signed. http://www.um.edu.mt/think/legal-contract-drafting-support/

  19. Basic Drafting: Book One.

    Davis, Ronald; And Others

    The first of a two-book course in drafting, this manual consists of 13 topics in the following units: introduction to drafting, general safety, basic tools and lines, major equipment, applying for a job, media, lettering, reproduction, drawing sheet layout, architect's scale usage, civil engineer's scale usage, mechanical engineer's scale usage,…

  20. Categorizing health-related cues to action: using Yelp reviews of restaurants in Hawaii

    Ariyasriwatana, W.; Buente, W.; Oshiro, M.; Streveler, D.

    2014-10-01

    Yelp, a social media site, undeniably has an influence on consumers' food choice in spite of its ability to reflect consumers' real voice being criticized. Since unhealthy food choices contribute to health problems, such as obesity and malnourishment, we attempted to examine these problems by better understanding consumers through health-related cues to action-a construct from the Health Belief Model (HBM)- on Yelp Honolulu's restaurant reviews. Our research revealed 13 main categories: Ingredient, Type of food, Taste, Lifestyle, Cooking, Option, Price, Portion, Well-being, Nutrition, Hygiene, Emotional attachment and indulgence, and Feeling. We argue that these categories may ultimately lead consumers to make healthier food choices. In search of the most appealing way to communicate with the target group, underlying concepts that derived from these categories can be tested. Marketers in food industry (or public health policy-makers) can craft their strategies for healthy food brands/products (or healthy eating scheme) based on the concept test research. Moreover, Yelp can apply these insights in the development of their algorithm and filter system in order to help consumers find healthy food if they wish to do so. Restaurants can also improve their strategy, menu, and communication execution to meet the growing demands of health conscious consumers.

  1. Thought-action fusion: review of the literature and future directions.

    Berle, David; Starcevic, Vladan

    2005-05-01

    Thought-action fusion (TAF) is the tendency for individuals to assume that certain thoughts either imply the immorality of their character or increase the likelihood of catastrophic events. The burgeoning literature on TAF is reviewed. It is not clear whether TAF refers to a specific appraisal style, a more enduring belief, or a combination of both. Inconsistent definitions of magical thinking have hindered better understanding of the relationship between TAF and magical thinking. Much work remains to be done to improve assessment and measurement of TAF. TAF is associated with tendencies towards obsessive-compulsive disorder (OCD) and may contribute to its symptoms. However, the literature investigating TAF and other variables implicated in OCD remains inconclusive. It is suggested that TAF is not specific to OCD, but also prevalent in other anxiety disorders. TAF appears to be moderately related to depressive symptoms and a similar bias may contribute to preoccupations in eating disorders. TAF is also associated with the presence of psychological disorders in children and adolescents. Educational and cognitive therapy approaches to reduce TAF and consequent symptoms are discussed, and suggestions for further research made. PMID:15792850

  2. Drafting method of electricity and electron design

    This book concentrates on drafting of electricity and electron design. It deals with The meaning of electricity and electron drafting JIS standard regulation the types of drafting and line and letter, basics drafting with projection drafting method, plan projection and development elevation, Drafting method of shop drawing, practical method of design and drafting, Design and drafting of technic and illustration, Connection diagram, Drafting of wiring diagram for light and illumination, Drafting of development connection diagram for sequence control, Drafting of logic circuit sign of flow chart and manual, drafting for a electron circuit diagram and Drawing of PC board.

  3. Career Directions for Drafting CAD Technicians.

    Moore, Pam

    2002-01-01

    Provides information careers for drafting/computer-assisted drafting technicians, including salaries, responsibilities, employment outlook, working conditions, skills needed, and career advancement opportunities. Lists professional drafting organizations. (JOW)

  4. Evaluations for draft reports on geological disposal

    This report summarizes the results of the technical evaluations on two reports which are named as 'Overview of the Geological Disposal Facility' and Considerable Factors on Selection of Potential Sites for Geological Disposal' drafted by NUMO (Nuclear Waste Management Organization of Japan). The review of each draft report has been referred to committee (held on 9th September, 2002) and working group (held on 1st October, 2002) which were organized in order to confirm a progress of implementation of geological disposal by government. (author)

  5. Review Essay: Von lokaler Praxis zu öffentlichem Wissen: Action Research als wissenschaftlicher Forschungsansatz

    Martí, Joel

    2008-01-01

    In den letzten Jahren hat Action Research schrittweise Eingang ins akademische Denken gefunden und auch Buchveröffentlichungen nach sich gezogen wie das hier besprochene The Action Research Dissertation, das im Besonderen auf Dissertationsprojekte (Forschungsprozess und Dokumentation) zielt. Neben eher technischen Aspekten (Kriterien und "Werkzeuge" für Action-Research-Dissertationen) werden in dem Buch einige Themen behandelt, die von essenzieller Bedeutung für universitäre Projekte sind, be...

  6. The action of corticosteroids on orthodontic tooth movement: a literature review

    Luegya Amorim Henriques Knop

    2012-12-01

    Full Text Available INTRODUCTION: Tooth movement is initially characterized by an acute sterile inflammation, followed by sequential multiple reactions in the periodontal ligament in response to biomechanical forces. Pharmacological agents such as corticosteroids may affect the course of orthodontic movement. Scientific studies show antagonistic actions of these drugs on bone resorption during tooth movement. OBJECTIVE: To review the literature about the effect of corticosteroids on orthodontic tooth movement. CONCLUSION: Patients should be questioned regarding the use of these drugs in the orthodontic practice and for those who use them, the orthodontic treatment should be differentiated, with longer intervals between visits and periodic X-rays due to the delay in bone formation observed in some scientific studies.INTRODUÇÃO: a movimentação dentária é caracterizada, inicialmente, por uma inflamação aguda estéril, seguida por reações múltiplas sequenciais no ligamento periodontal em resposta às forças biomecânicas. Agentes farmacológicos, como os corticosteroides, podem alterar o curso da movimentação ortodôntica. Os estudos científicos demonstram ações antagonistas dessas drogas sobre a reabsorção óssea durante a movimentação dentária. OBJETIVO: realizar revisão de literatura sobre a ação dos corticosteroides no movimento dentário ortodôntico. CONCLUSÃO: os pacientes devem ser questionados quanto ao uso dessas drogas na clínica ortodôntica e, para aqueles que fazem uso, o tratamento ortodôntico deve ser diferenciado, com intervalos maiores entre as consultas e solicitação periódica de radiografias devido ao atraso na neoformação óssea observado em alguns estudos científicos.

  7. Natural cures for type 1 diabetes: a review of phytochemicals, biological actions, and clinical potential.

    Chang, C L T; Chen, Yi-Ching; Chen, Hui-Ming; Yang, Ning-Sun; Yang, Wen-Chin

    2013-01-01

    Autoimmune diseases are the third largest category of illness in the industrialized world, following cardiovascular diseases and cancers. Among them, type 1 diabetes, also named autoimmune diabetes, afflicts 10 million people worldwide. This disease is caused by autoimmunity-mediated destruction of pancreatic β-cells, leading to insulin deficiency, hyperglycemia and complications. Currently, there is no cure for type 1 diabetes. Insulin injection is the only medication; however, it accompanies serious medical complications. Current strategies to cure type 1 diabetes include immunotherapy, replacement therapy, and combination therapy. Despite recent advances in anti-diabetic strategies, no strategy is clinically successful. How to cure type 1 diabetes without undesirable side effects still remains a formidable challenge in drug research and development. Plants provide an extraordinary source of natural medicines for different diseases. Moreover, secondary metabolites of plant origin serve as an invaluable chemical library for drug discovery and current medicinal chemistry in the pharmaceutical industry. Over the past 25 years, 50% of prescription drugs have been developed from natural products and their derivatives. In this article, we review more than 20 plant compounds and extracts reported in the literature to prevent and treat type-1 diabetes. Emphasis is placed on their chemistry and biology in terms of regulation of immune cells and pancreatic β-cells. We summarize recent progress in understanding the biological actions, mechanisms and therapeutic potential of the compounds and extracts of plant origin in type 1 diabetes. New views on phytocompound-based strategies for prevention and treatment of type 1 diabetes are also discussed. PMID:23210779

  8. Economic evidence on identifying clinically actionable findings with whole-genome sequencing: a scoping review.

    Douglas, Michael P; Ladabaum, Uri; Pletcher, Mark J; Marshall, Deborah A; Phillips, Kathryn A

    2016-02-01

    The American College of Medical Genetics and Genomics (ACMG) recommends that mutations in 56 genes for 24 conditions are clinically actionable and should be reported as secondary findings after whole-genome sequencing (WGS). Our aim was to identify published economic evaluations of detecting mutations in these genes among the general population or among targeted/high-risk populations and conditions and identify gaps in knowledge. A targeted PubMed search from 1994 through November 2014 was performed, and we included original, English-language articles reporting cost-effectiveness or a cost-to-utility ratio or net benefits/benefit-cost focused on screening (not treatment) for conditions and genes listed by the ACMG. Articles were screened, classified as targeting a high-risk or general population, and abstracted by two reviewers. General population studies were evaluated for actual cost-effectiveness measures (e.g., incremental cost-effectiveness ratios (ICER)), whereas studies of targeted populations were evaluated for whether at least one scenario proposed was cost-effective (e.g., ICER of ≤$100,000 per life-year or quality-adjusted life-year gained). A total of 607 studies were identified, and 32 relevant studies were included. Identified studies addressed fewer than one-third (7 of 24; 29%) of the ACMG conditions. The cost-effectiveness of screening in the general population was examined for only 2 of 24 conditions (8%). The cost-effectiveness of most genetic findings that the ACMG recommends for return has not been evaluated in economic studies or in the context of screening in the general population. The individual studies do not directly address the cost-effectiveness of WGS. PMID:25996638

  9. Mechanisms of action of brief alcohol interventions remain largely unknown – A narrative review

    Jacques eGaume

    2014-08-01

    Full Text Available A growing body of evidence has shown efficacy of brief intervention (BI for hazardous and harmful alcohol use in primary health care settings. Evidence for efficacy in other settings, and effectiveness when implemented at larger scale is disappointing. Indeed, BI comprises varying content, and exploring BI content and mechanisms of action may be a promising way to enhance efficacy and effectiveness.We searched Medline and PsychInfo, as well as references of retrieved publications for original research or reviews on active ingredients (or components, or mechanisms of face-to-face BIs (and its subtypes, including brief advice and brief motivational interviewing [BMI] for alcohol. Overall, BI active ingredients have been scarcely investigated, almost only within BMI, and mostly among Emergency Room patients, young adults, and US college students. This body of research has shown that personalized feedback may be an effective component; specific MI techniques showed mixed findings; decisional balance findings tended to suggest a potential detrimental effect; while change plan exercises, advice to reduce or stop drinking, presenting alternative change options, and moderation strategies are promising but need further study. Client change talk is a potential mediator of BMI effects; change in norm perceptions and enhanced discrepancy between current behavior and broader life goals and values have received preliminary support; readiness to change was only partially supported as a mediator; while enhanced awareness of drinking, perceived risks/benefits of alcohol use, alcohol treatment seeking, and self-efficacy were seldom studied and have as yet found no significant support as such.Research is obviously limited and has provided no clear and consistent evidence on the mechanisms of alcohol BI. How BI achieves the effects seen in randomized trials remains mostly unknown and should be investigated to inform the development of more effective interventions.

  10. Impact of safety-related regulatory action on clinical practice : a systematic review

    Piening, S.; Haaijer-Ruskamp, F.M.; de Vries, J.T.; van der Elst, M.E.; de Graeff, P.A.; Straus, S.M.; Mol, P.G.

    2012-01-01

    Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of th

  11. Impact of Safety-Related Regulatory Action on Clinical Practice A Systematic Review

    Piening, Sigrid; Haaijer-Ruskamp, Flora M.; de Vries, Jonie T. N.; van der Elst, Menno E.; de Graeff, Pieter A.; Straus, Sabine M. J. M.; Mol, Peter G. M.

    2012-01-01

    Background: After market approval, new serious safety issues are regularly identified for drugs that lead to regulatory action to inform healthcare professionals. However, the effectiveness of these safety-related regulatory actions is under question. We currently lack a comprehensive overview of th

  12. Public Review Draft: A Method for Assessing Carbon Stocks, Carbon Sequestration, and Greenhouse-Gas Fluxes in Ecosystems of the United States Under Present Conditions and Future Scenarios

    Bergamaschi, Brian A.; Bernknopf, Richard; Clow, David; Dye, Dennis; Faulkner, Stephen; Forney, William; Gleason, Robert; Hawbaker, Todd; Liu, Jinxun; Liu, Shu-Guang; Prisley, Stephen; Reed, Bradley; Reeves, Matthew; Rollins, Matthew; Sleeter, Benjamin; Sohl, Terry; Stackpoole, Sarah; Stehman, Stephen; Striegl, Rob; Wein, Anne; Zhu, Zhi-Liang

    2010-01-01

    The Energy Independence and Security Act of 2007 (EISA), Section 712, authorizes the U.S. Department of the Interior to develop a methodology and conduct an assessment of the Nation's ecosystems focusing on carbon stocks, carbon sequestration, and emissions of three greenhouse gases (GHGs): carbon dioxide, methane, and nitrous oxide. The major requirements include (1) an assessment of all ecosystems (terrestrial systems, such as forests, croplands, wetlands, shrub and grasslands; and aquatic ecosystems, such as rivers, lakes, and estuaries), (2) an estimation of annual potential capacities of ecosystems to increase carbon sequestration and reduce net GHG emissions in the context of mitigation strategies (including management and restoration activities), and (3) an evaluation of the effects of controlling processes, such as climate change, land use and land cover, and wildlfires. The purpose of this draft methodology for public review is to propose a technical plan to conduct the assessment. Within the methodology, the concepts of ecosystems, carbon pools, and GHG fluxes used for the assessment follow conventional definitions in use by major national and international assessment or inventory efforts. In order to estimate current ecosystem carbon stocks and GHG fluxes and to understand the potential capacity and effects of mitigation strategies, the method will use two time periods for the assessment: 2001 through 2010, which establishes a current ecosystem GHG baseline and will be used to validate the models; and 2011 through 2050, which will be used to assess future potential conditions based on a set of projected scenarios. The scenario framework is constructed using storylines of the Intergovernmental Panel on Climate Change (IPCC) Special Report Emission Scenarios (SRES), along with initial reference land-use and land-cover (LULC) and land-management scenarios. An additional three LULC and land-management mitigation scenarios will be constructed for each

  13. Book Review ~ Action learning: Images and pathways. Author: Robert L. Dilworth and Verna J. Willis

    Reviewed by Patrick J. Fahy

    2003-01-01

    Action learning, as defined in this book, is “a process of reflecting on one’s work and beliefs in the supportive/ confrontational environment of one’s peers for the purpose of gaining new insights and resolving real business and community problems in real time” (p. 11). The claims made for action learning are impressive. Action learning: * Allows participants (who work in groups called sets) to answer the question, “What is an honest man, and what do I need to do to become one?” (p. viii)...

  14. 75 FR 7256 - Denali Commission Fiscal Year 2010 Draft Work Plan

    2010-02-18

    ...). The Denali Commission Act requires that the Commission develop proposed work plans for future spending... Commission Fiscal Year 2010 Draft Work Plan AGENCY: Denali Commission. ACTION: Denali Commission Fiscal Year 2010 Draft Work Plan request for comments. SUMMARY: The Denali Commission (Commission) is...

  15. 75 FR 69649 - Notice of Availability for the Draft Programmatic Environmental Assessment for the Development...

    2010-11-15

    ... comment period begins upon publication of a Notice of Availability (NOA) for the Draft PEA in the Federal..., present, and reasonably foreseeable future actions. Schedule: NOA of the Draft PEA will be published in... a NOA of the FONSI or Notice of Intent (NOI) to prepare an EIS will be published. Dated: November...

  16. 76 FR 54502 - Energy Northwest, Columbia Generating Station; Notice of Availability of Draft Supplement 47 to...

    2011-09-01

    ... COMMISSION Energy Northwest, Columbia Generating Station; Notice of Availability of Draft Supplement 47 to... Regulatory Commission (NRC) has published a draft plant-specific supplement to the Generic Environmental... renewal) include no action and reasonable alternative energy sources. Any interested party may...

  17. 78 FR 68852 - Draft Guidance for Industry on Acrylamide in Foods; Availability

    2013-11-15

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Acrylamide in Foods; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA or we) is announcing the availability of a draft guidance entitled ``Guidance for...

  18. 77 FR 67379 - Draft Guidance for Industry and Food and Drug Administration Staff; Highly Multiplexed...

    2012-11-09

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration... Devices; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and... pathogen nucleic acids extracted from a single appropriate human specimen or culture. This draft...

  19. A Conceptual Review on Action-Perception Coupling in the Musicians’ Brain: What Is It Good for?

    Giacomo Novembre

    2014-08-01

    Full Text Available Experience with a sensorimotor task, such as practicing a piano piece, leads to strong coupling of sensory (visual or auditory and motor cortices. Here we review behavioural and neurophysiological (M/EEG, TMS and fMRI research exploring this topic using the brain of musicians as a model system. Our review focuses on a recent body of evidence suggesting that this form of coupling might have (at least two cognitive functions. First, it leads to the generation of equivalent predictions (concerning both when and what event is more likely to occur during both perception and production of music. Second, it underpins the common coding of perception and action that supports the integration of the motor output of multiple musicians’ in the context of joint musical tasks. Essentially, training-based coupling of perception and action might scaffold the human ability to represent complex (structured actions and to entrain multiple agents – via reciprocal prediction and adaptation – in the pursuit of shared goals.

  20. MYRRHA Draft-2 Design accomplishments

    One of the main SCK-CEN research facility, namely the Materials Testing Reactor (MTR) BR2, is nowadays in operation for more than 40 years. The need for a safe and economic operation of the European nuclear park for preserving the natural resources, demand the start-up of one or more new MTRs in a very near future. On the other hand the closing of the fuel cycle as well as the development of future energy systems request clearly the use of fast spectrum irradiation facilities. The MYRRHA project started at SCK-CEN in this context, the concept of a new irradiation and testing facility to replace BR2. MYRRHA, being a fast neutron facility, would be a complementary project to the thermal MTR Jules Horowitz Reactor in France. That would give Europe a full research capacity in terms of nuclear research and development for Generation III and IV reactors. At mid-2002, a first pre-design file of MYRRHA (namely the ''MYRRHA Draft - 1'' file with a core nominal power of 30 MWth) has been submitted to an International Technical Guidance Committee (ITGC) for reviewing. No show stopper has been identified in the project. Nevertheless, the ITGC members have recommended: (1) to give more attention to safety studies and iterate to the pre-design before entering the detailed engineering phase; (2) to address some RandD topics to avoid bottlenecks such as fuel pin and assembly development and qualification; (3) to make a decision on the accelerator option (cyclotron or LINAC) and possibly revisit the beam parameters that were already at that moment fixed to 350 MeV*5 mA but mainly derived from the cyclotron technology possibilities. The objective of this effort in the period 2003-2005 was to update and progress the MYRRHA Draft-1 design based on the ITGC evaluation results, the consequences of the safety studies that had to be accomplished on basis of the Draft-1 design and holding the initial objectives of the MYRRHA facility. This resulted at mid-2005 in producing the MYRRHA Draft

  1. May spa therapy be a valid opportunity to treat hand osteoarthritis? A review of clinical trials and mechanisms of action

    Fortunati, Nicola Angelo; Fioravanti, Antonella; Seri, Gina; Cinelli, Simone; Tenti, Sara

    2016-01-01

    Osteoarthritis (OA) is the most common form of arthritis and its current treatment includes non-pharmacological and pharmacological modalities. Spa therapy represents a popular treatment for many rheumatic diseases. The aim of this review was to summarize the currently available information on clinical effects and mechanisms of action of spa therapy in OA of the hand. We conducted a search of the literature to extract articles describing randomized clinical trials (RCTs) in hand OA published in the period 1952-2015. We identified three assessable articles reporting RCTs on spa therapy in hand OA. Data from these clinical trials support a beneficial effect of spa therapy on pain, function and quality of life in hand OA. Spa therapy seems to have a role in the treatment of hand OA. However, additional RCTs are necessary to clarify the mechanisms of action and the effects of the application of thermal treatments.

  2. 77 FR 68790 - Program Comment Issued for Streamlining Section 106 Review for Actions Affecting Post-1945...

    2012-11-16

    ... Concrete and Steel Bridges AGENCY: Advisory Council on Historic Preservation. ACTION: Program Comment... Program Comment applies to effects of undertakings on certain common concrete and steel bridges lacking... post- 1945 concrete and steel bridges would remain unidentified and unprotected in the absence of...

  3. Going to Action? A Literature Review on Educational Proposals in Formal Environmental Education

    Varela-Losada, Mercedes; Vega-Marcote, Pedro; Pérez-Rodríguez, Uxío; Álvarez-Lires, María

    2016-01-01

    The current state of the planet's environmental deterioration calls for formal educational contexts to implement effective environmental proposals which nurture action competence. The aim of this paper is to examine the educational proposals in formal contexts that have been published in the two research journals of greatest impact on…

  4. What predicts intention-behavior discordance? A review of the action control framework

    R.E. Rhodes; G.J. de Bruijn

    2013-01-01

    The physical activity intention-behavior gap is a focus of considerable research. The purpose of this article is to overview contemporary evidence for predictors of this intention-behavior discordance using the action control framework developed in our laboratories. We propose the hypothesis that in

  5. Book Review ~ Action learning: Images and pathways. Author: Robert L. Dilworth and Verna J. Willis

    Reviewed by Patrick J. Fahy

    2003-10-01

    Full Text Available Action learning, as defined in this book, is “a process of reflecting on one’s work and beliefs in the supportive/ confrontational environment of one’s peers for the purpose of gaining new insights and resolving real business and community problems in real time” (p. 11. The claims made for action learning are impressive. Action learning: * Allows participants (who work in groups called sets to answer the question, “What is an honest man, and what do I need to do to become one?” (p. viii. * Is more than learning by doing, action learning “has the potential for putting control of lifelong learning directly in the hands of learners, in ways that alter their perceptions, amplify self-efficacy, and re-connect these individuals to spontaneous curiosity and confidence in the exercise of their own good judgment” (p. xi. * Is a “sleeping giant in the catalogue of individual and organizational change strategies” (p. xi. * Is believed to address the five most important needs facing organizations today: 1 problem-solving; 2 organizational learning; 3 leadership development; 4 professional growth; and 5 career development (p. xiii.

  6. Book Review: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice

    Frederik Holst; Humboldt-Universität zu Berlin

    2014-01-01

    Book Review of the edited compilation: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice; Singapore: NUS Press, ISBN 978-697-5832-67-3, 412 pages

  7. Book Review: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice

    Frederik Holst

    2013-01-01

    Book Review of the edited compilation: Gomez, Edmund Terence, and Johan Saravanamuttu (eds) (2012), The New Economic Policy in Malaysia: Affirmative Action, Ethnic Inequalities and Social Justice; Singapore: NUS Press, ISBN 978-697-5832-67-3, 412 pages

  8. 78 FR 57859 - Draft Guidance for Industry on Endocrine Disruption Potential of Drugs: Nonclinical Evaluation...

    2013-09-20

    ... Potential of Drugs: Nonclinical Evaluation; Availability AGENCY: Food and Drug Administration, HHS. ACTION... guidance for industry entitled ``Endocrine Disruption Potential of Drugs: Nonclinical Evaluation.'' This... determine the potential for a drug to disrupt the endocrine system. This draft guidance also...

  9. 76 FR 43689 - Draft Guidance for Industry and Food and Drug Administration Staff; Mobile Medical Applications...

    2011-07-21

    ... Staff; Mobile Medical Applications; Availability AGENCY: Food and Drug Administration, HHS. ACTION... guidance entitled ``Mobile Medical Applications.'' FDA is issuing this draft guidance to inform... select software applications intended for use on mobile platforms (mobile applications or ``mobile...

  10. 76 FR 50740 - Draft Guidance for Industry and Food and Drug Administration Staff; Procedures for Handling...

    2011-08-16

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff; Procedures for Handling Section 522 Postmarket Surveillance Studies; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  11. 78 FR 55727 - Draft Guidance for Industry on Recommendations for Preparation and Submission of Animal Food...

    2013-09-11

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Recommendations for Preparation and Submission of Animal Food Additive Petitions; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing...

  12. A summary of the November 1992, final guidelines for the preparation of an environmental impact statement for the proposed Conawapa project draft for review and comment

    Manitoba Hydro has proposed the Conawapa Project, which includes the design, construction, operation, maintenance, and decommissioning of the Conawapa generating station, new Riel converter station and ground electrode, new Bipole II transmission line, expansion of the existing Henday converter station, new Riel-Dorsey transmission line, upgrading of the Southern Receiver system, new Henday-Riel and Riel-Ontario transmission lines, and ancillary facilities and activities. An environmental impact statement must be prepared to identify valued environmental components of the ecosystem and components and activities of the social, economic and cultural systems of communities affected by the proposed project. The guidelines cover project need and justification, project description, description of the environmental setting, environmental impacts, and response to environmental impacts. This document includes a summary of the draft guidelines together with the guidelines themselves. 10 refs., 3 figs

  13. Minutes from Department of Energy/Hazardous Waste Remedial Actions Program, research and development technology needs assessment review meeting for FY 1990, September 1989, Oak Ridge, Tennessee

    On September 20--21, 1989, representatives of the Department of Energy (DOE) Headquarters, DOE Operations Offices, DOE contractors, and the Hazardous Waste Remedial Actions Program met in Oak Ridge, Tennessee, to select and prioritize candidate waste problems in need of research and development. The information gained will be used in planning for future research and development tasks and in restructuring current research activities to address the priority needs. Consistent with the ongoing reevaluation of DOE's plans for environmental restoration and waste management, an attempt was made to relate the needs developed in this meeting to the needs expressed in the draft Applied Research, Development, Demonstration, Testing, and Evaluation Plan. Operations Offices were represented either by DOE staff or by contractor delegates from the area. This document summarizes the results of the meeting and lists the priority waste problems established

  14. Book Review: Making British law: committees in action by Louise Thompson

    Berry, Richard

    2015-01-01

    In Making British Law: Committees in Action, Louise Thompson presents a history and statistical analysis of the work of bill committees – formerly known as standing committees – and their influence over the process of making British law. Thompson offers a well-evidenced argument that goes beyond the statistics to persuasively account for the role and importance of MPs in shaping government legislation through bill committees, writes Richard Berry.

  15. Review of decision methodologies for evaluating regulatory actions affecting public health and safety

    This report examines several aspects of the problems and choices facing the governmental decision maker who must take regulatory actions with multiple decision objectives and attributes. Particular attention is given to the problems facing the U.S. Nuclear Regulatory Commission (NRC) and to the decision attribute of chief concern to NRC, the protection of human health and safety, with emphasis on nuclear power plants. The study was undertaken to provide background information for NRC to use in refining its process of value/impact assessment of proposed regulatory actions. The principal conclusion is that approaches to rationally consider the value and impact of proposed regulatory actions are available. These approaches can potentially improve the decision-making process and enable the agency to better explain and defend its decisions. They also permit consistent examination of the impacts, effects of uncertainty and sensitivity to various assumptions of the alternatives being considered. Finally, these approaches can help to assure that affected parties are heard and that technical information is used appropriately and to the extent possible. The principal aspects of the regulatory decision problem covered in the report are: the legal setting for regulatory decisions which affect human health and safety, elements of the decision-making process, conceptual approaches to decision making, current approaches to decision making in several Federal agencies, and the determination of acceptable risk levels

  16. Mechanism of Action of Ulipristal Acetate for Emergency Contraception: A Systematic Review.

    Rosato, Elena; Farris, Manuela; Bastianelli, Carlo

    2015-01-01

    Ulipristal acetate (UPA) is now recommended as first choice hormonal emergency contraception (EC), due to its higher efficacy and similar safety compared to Levonorgestrel - EC. Even though all trials demonstrated that the first mechanism of action is inhibition of ovulation, some authors still postulate that a post fertilization effect is also possible, raising the alert on medication and fostering the ethical debate. A Medline database search was performed in order to find recent articles related to UPA's effects on ovulation, on fallopian tube and on endometrium. We also analyzed the effects on sperm function and pregnancy. All studies conclude that UPA is effective in inhibition of ovulation even when administered shortly before LH peak. The effects on fallopian tube are unclear: according to some authors UPA inhibits ciliar beat through an agonistic effect on progesterone receptors, according to others it antagonizes the progesterone-induced ciliar beat decrease. Concerning the action on endometrium and on embryo implantation most of the studies concluded that low dose UPA used for EC has no significant effect on the decrease of endometrial thickness and on embryo's attachment, but these results are still matter of debate. Finally recent evidence suggests that UPA modulates human sperm functions while it has no effect on established pregnancy. To date the majority of the evidence concurs in excluding a post-fertilization effect of UPA, even though more studies are needed to clarify its mechanism of action. PMID:26793107

  17. Mechanism of action of ulipristal acetate for emergency contraception: a systematic review

    Elena eRosato

    2016-01-01

    Full Text Available SUMMARYUlipristal acetate (UPA is now recommended as first choice hormonal Emergency Contraception (EC, due to its higher efficacy and similar safety compared to Levonogestrel - EC. Even though all trials demonstrated that the first mechanism of action is inhibition of ovulation, some authors still postulate that a post fertilization effect is also possible, raising the alert on medication and fostering the ethical debate.A Medline database search was performed in order to find recent articles related to UPA’s effects on ovulation, on fallopian tube and on endometrium. We also analyzed the effects on sperm function and pregnancy. All studies conclude that UPA is effective in inhibition of ovulation even when administered shortly before LH peak. The effects on fallopian tube are unclear: according to some authors UPA inhibits ciliar beat through an agonistic effect on progesterone receptors, according to others it antagonizes the progesterone-induced ciliar beat decrease. Concerning the action on endometrium and on embryo implantation most of the studies concluded that low dose UPA used for EC has no significant effect on the decrease of endometrial thickness and on embryo’s attachment, but these results are still matter of debate. Finally recent evidence suggests that UPA modulates human sperm functions while it has no effect on established pregnancy. To date the majority of the evidence concur in excluding a post-fertilization effect of UPA, even though more studies are needed to clarify its mechanism of action.

  18. Probiotics as beneficial microbes in aquaculture: an update on their multiple modes of action: a review

    Zorriehzahra, Mohammad Jalil; Delshad, Somayeh Torabi; Adel, Milad;

    2016-01-01

    Wide and discriminate use of antibiotics has resulted in serious biological and ecological concerns, especially the emergence of antibiotic resistance. Probiotics, known as beneficial microbes, are being proposed as an effective and eco-friendly alternative to antibiotics. They were first applied...... in aquaculture species more than three decades ago, but considerable attention had been given only in the early 2000s. Probiotics are defined as live or dead, or even a component of the microorganisms that act under different modes of action in conferring beneficial effects to the host or to its...

  19. Review Essay: From Local Practices to Public Knowledge: Action Research as Scientific Contribution

    Martí, Joel

    2008-01-01

    En los últimos años la investigación acción se ha ido introduciendo progresivamente en la reflexión académica y, con ello, han aparecido publicaciones como The Action Research Dissertation, específicamente orientadas a la realización y presentación de memorias de investigación desde estas metodologías. Más allá de los aspectos puramente instrumentales (aportar criterios y herramientas para la realización de trabajos académicos mediante investigación acción), el libro plantea algunos puntos qu...

  20. Drafting the Basics

    Lamb, Carol M.; Kurtanich, David G.

    2007-01-01

    This paper outlines the work in progress undertaken by the School of Engineering Technology faculty to identify, assess, and develop a course to address the depth and breadth of drafting/plan preparation and plan reading skills required by the various engineering technology programs offered at Youngstown State University. The methodology used to…

  1. Caught in the Draft

    Edge, Ron

    2007-01-01

    We've all seen (in movies, newscasts, or perhaps in person) the violent effect of the downwash that occurs when a helicopter hovers over the ground. Leaves, grass, and debris are dramatically blown about. We've also sat in front of circulating room fans and felt a large draft, whereas there seems to be very little air movement behind the fan. The…

  2. Drafting Lab Management Guide.

    Ohio State Univ., Columbus. Instructional Materials Lab.

    This manual was developed to guide drafting instructors and vocational supervisors in sequencing laboratory instruction and controlling the flow of work for a 2-year machine trades training program. The first part of the guide provides information on program management (program description, safety concerns, academic issues, implementation…

  3. 77 FR 67635 - Fiscal Year 2013 Draft Work Plan

    2012-11-13

    ... with passage of the October 21, 1998 Denali Commission Act (Act) (Title III of Pub. L. 105-277, 42 U.S.C. 3121). The Act requires that the Commission develop proposed work plans for future spending and... Year 2013 Draft Work Plan AGENCY: Denali Commission. ACTION: Notice. SUMMARY: The Denali...

  4. Health Literacy and Health Actions: A Review and a Framework from Health Psychology

    von Wagner, Christian; Steptoe, Andrew; Wolf, Michael S.; Wardle, Jane

    2009-01-01

    The association between performance on health literacy measures and health outcomes is well established. The next step is to understand the processes through which health literacy affects health. This review introduces a framework drawing on ideas from health psychology and proposing that associations between health literacy and health outcomes…

  5. Stylizing Genderlect Online for Social Action: A Corpus Analysis of "BIC Cristal for Her" Reviews

    Ray, Brian

    2016-01-01

    This article introduces the concept of stylization and illustrates its usefulness for studying online discourse by examining how writers have employed it in order to parody sexist products such as BIC Cristal for Her, using genderlect in order to introduce dissonance into and reframe patriarchal discourse. A corpus analysis of 671 reviews, written…

  6. 78 FR 40199 - Draft Spent Fuel Storage and Transportation Interim Staff Guidance

    2013-07-03

    ... COMMISSION Draft Spent Fuel Storage and Transportation Interim Staff Guidance AGENCY: Nuclear Regulatory... Regulatory Commission (NRC) requests public comment on Draft Spent Fuel Storage and Transportation Interim... given in NUREG-1927 ``Standard Review Plan for Renewal of Spent Fuel Dry Cask Storage System...

  7. 78 FR 29153 - Notice of Availability of the Draft Resource Management Plan and Environmental Impact Statement...

    2013-05-17

    ... fall 2010 to give the public an opportunity to review the route inventory for completeness and accuracy...; and special designations. The Draft RMP/Draft EIS evaluates, in detail, five alternatives, including... that would occur if formally designated are as follows: Big Dominguez Canyon ACEC--5,626...

  8. 76 FR 28789 - Draft Alert Entitled “Preventing Occupational Respiratory Disease From Dampness in Office...

    2011-05-18

    ... HUMAN SERVICES Centers for Disease Control and Prevention Draft Alert Entitled ``Preventing Occupational... Disease Control and Prevention (CDC), announces the availability of a draft Alert entitled ``Preventing... found at: http://nioshdev.cdc.gov/niosh/docket/review/docket238/default.html . The purpose of this...

  9. 75 FR 6696 - Draft Recovery Plan for Tidal Marsh Ecosystems of Northern and Central California

    2010-02-10

    ... Fish and Wildlife Service Draft Recovery Plan for Tidal Marsh Ecosystems of Northern and Central... draft recovery plan for Tidal Marsh Ecosystems of Northern and Central California for public review and... Marsh Ecosystems of Northern and Central California features five endangered species. The biology...

  10. 76 FR 51034 - Availability of Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy...

    2011-08-17

    ... Chemotherapy During Pregnancy; Request for Comments; Announcement of a Panel Meeting To Peer Review Draft... of the Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy During Pregnancy... of Cancer Chemotherapy During Pregnancy, which has been prepared by the NTP Office of...

  11. Performance Reporting - The IASB's Proposed Formats of Financial Statements in the Exposure Draft of IAS1

    Thinggaard, Frank; Wagenhofer, Alfred; Evans, Lisa;

    2006-01-01

    This paper is a response to the Exposure Draft of proposed amendments to IAS 1 Presentation of Financial Statements published by the IASB in March 2006. The objective is to bring to the standard setter’s attention research that is relevant to the issues raised in the exposure draft. We review...

  12. Safety and health in forest harvesting operations. Diagnosis and preventive actions. A review

    P. Albizu-Urionabarrenetxea; E. Tolosana-Esteban; E. Roman-Jordan

    2013-01-01

    Aim of study: to review the present state of the art in relation to the main labour risks and the most relevant results of recent studies evaluating the safety and health conditions of the forest harvesting work and better ways to reduce accidents.Area of study: It focuses mainly on developed Countries, where the general concern about work risks prevention, together with the complex idiosyncrasy of forest work in forest harvesting operations, has led to a growing interest from the forest scie...

  13. Review of ultrasonic irrigation in endodontics: increasing action of irrigating solutions

    Mozo, Sandra; Llena, Carmen; Forner, Leopoldo

    2011-01-01

    Introduction: Effective irrigant delivery and agitation are prerequisites for successful endodontic treatment. Ultrasonic irrigation can be performed with or without simultaneous ultrasonic instrumentation. Existing literature reveals that ultrasonic irrigation may have a very positive effect on chemical, biological and physical debridement of the root canal system as investigated in many in vitro studies. Objective: The purpose of this review article was to summarize and discuss the availabl...

  14. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review.

    Majdalawieh, Amin F; Fayyad, Muneera W

    2015-09-01

    Many herbal products are now used as remedies to treat various infectious and non-infectious conditions. Even though the use of herbs and natural products is much more evident in the Eastern world, their use in Western cultures is continuously increasing. Although the immunomodulatory effects of some herbs have been extensively studied, research related to possible immunomodulatory effects of many herbs and various spices is relatively scarce. Here, we provide a comprehensive review of the immunomodulatory and anti-inflammatory properties of Nigella sativa, also known as black seed or black cumin, and its major active ingredient, thymoquinone (TQ). This review article focuses on analyzing in vitro and in vivo experimental findings that were reported with regard to the ability of N. sativa and TQ to modulate inflammation, cellular and humoral adaptive immune responses, and Th1/Th2 paradigm. The reported capability of N. sativa to augment the cytotoxic activity of natural killer (NK) cells against cancer cells is also emphasized. The molecular and cellular mechanisms underlying such immunomodulatory and anti-inflammatory effects of N. sativa and TQ are highlighted. Moreover, the signal transduction pathways implicated in the immunoregulatory functions of N. sativa and TQ are underscored. Experimental evidence suggests that N. sativa extracts and TQ can potentially be employed in the development of effective therapeutic agents towards the regulation of immune reactions implicated in various infectious and non-infectious conditions including different types of allergy, autoimmunity, and cancer. PMID:26117430

  15. 78 FR 20326 - Draft Compliance Policy Guide Sec. 100.250 Food Facility Registration-Human and Animal Food...

    2013-04-04

    ... HUMAN SERVICES Food and Drug Administration Draft Compliance Policy Guide Sec. 100.250 Food Facility Registration--Human and Animal Food; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of draft Compliance...

  16. 75 FR 12171 - Notice of Availability of a Draft Pest Risk Assessment on Honey Bees Imported from Australia

    2010-03-15

    ... Honey Bees Imported from Australia AGENCY: Animal and Plant Health Inspection Service, USDA. ACTION... importation of honey bees from Australia. The draft pest risk assessment considers potential pest risks... honey bee pathogens or parasites may have been introduced into Australia. We are making the draft...

  17. 76 FR 47612 - NextEra Energy Seabrook, LLC; Notice of Availability of Draft Supplement 46 to the Generic...

    2011-08-05

    ... COMMISSION NextEra Energy Seabrook, LLC; Notice of Availability of Draft Supplement 46 to the Generic...) has published a draft plant-specific supplement to the Generic Environmental Impact Statement for... renewal) include no action and reasonable alternative energy sources. Any interested party may...

  18. 76 FR 11506 - Fisheries and Habitat Conservation and Migratory Birds Programs; Draft Land-Based Wind Energy...

    2011-03-02

    ...; Draft Land-Based Wind Energy Guidelines; Correction AGENCY: Fish and Wildlife Service, Interior. ACTION... comment of draft Land-Based Wind Energy Guidelines (Guidelines). We are issuing a correction to that... a notice in the Federal Register on February 18, 2011 (76 FR 9590), announcing the availability...

  19. 75 FR 8968 - Draft Guidance for Industry on Adaptive Design Clinical Trials for Drugs and Biologics; Availability

    2010-02-26

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Adaptive Design Clinical Trials for Drugs and Biologics; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a draft...

  20. 76 FR 10342 - Availability of Fiscal Years 2011-2016 Draft Strategic Plan and Request for Public Comment

    2011-02-24

    ... leadership in strategic areas of importance to the Department's missions. Our goal for securing our nation is... Availability of Fiscal Years 2011-2016 Draft Strategic Plan and Request for Public Comment AGENCY: Department of Energy (DOE). ACTION: Notice of availability of DOE's Draft Strategic Plan and request for...

  1. Students' drafting strategies and text quality

    Piolat, A.; Roussey, JY

    1996-01-01

    The study reports an analysis of the drafts produced by two groups of students during an exam. Drafts were categorized as a function of some of their graphic features (e.g. their length), and of their different planning strategies used for their production (e.g. note draft, organized draft, composed draft). Grades obtained by the students on their essays related to the different categories of drafts. Results show that 2/3 of both groups of students made some kinds of draft. Drafts mostly cons...

  2. Parents’ actions, challenges, and needs while enabling participation of children with a physical disability: a scoping review

    Piškur Barbara

    2012-11-01

    Full Text Available Abstract Background Pediatric rehabilitation considers Family-centered service (FCS as a way to increase participation of children with a physical disability in daily life. An important principal is that parents greatly contribute to their child’s participation at school, at home, and in the community. However, it is unclear what kind of information is available from literature about what parents actually do to support their child’s participation and what problems and needs they experience? Hence, the aim of this study was to provide an overview of the actions, challenges, and needs of parents in enabling participation of their child with a physical disability that is neurological and non-progressive in nature. Methods Scoping review with extensive literature search (September 2011 and a thematic analysis to synthesize findings. Results Fourteen relevant articles revealed two major themes: ‘parents enable and support performance of meaningful activities’ and ‘parents enable, change and use the environment’. Each theme holds a number of actions (e.g. choosing the right type of meaningful activities for facilitating social contacts and challenges (e.g. negative attitudes of other people. Less information is available about the needs of parents. Conclusions This study indicates that parents apply a broad range of strategies to support participation of their children. They experience many challenges, especially as a result of constraints in the social and physical environments. However, this review also shows that little is known about needs of parents in facilitating participation. As Family-centered service (FCS philosophy is all about the needs of the child and the family, it is essential to further investigate the needs of the parents and to understand if and to what extent they wish to be supported in enabling their child’s participation in daily life.

  3. Oil spill impacts on mangroves: Recommendations for operational planning and action based on a global review.

    Duke, Norman C

    2016-08-30

    Mangrove tidal wetland habitats are recognised as highly vulnerable to large and chronic oil spills. This review of current literature and public databases covers the last 6 decades, summarising global data on oil spill incidents affecting, or likely to have affected, mangrove habitat. Over this period, there have been at least 238 notable oil spills along mangrove shorelines worldwide. In total, at least 5.5milliontonnes of oil has been released into mangrove-lined, coastal waters, oiling possibly up to around 1.94millionha of mangrove habitat, and killing at least 126,000ha of mangrove vegetation since 1958. However, there were assessment limitations with incomplete and unavailable data, as well as unequal coverage across world regions. To redress the gaps described here in reporting on oil spill impacts on mangroves and their recovery worldwide, a number of recommendations and suggestions are made for refreshing and updating standard operational procedures for responders, managers and researchers alike. PMID:27373945

  4. Using Social Media for Actionable Disease Surveillance and Outbreak Management: A Systematic Literature Review.

    Lauren E Charles-Smith

    Full Text Available Research studies show that social media may be valuable tools in the disease surveillance toolkit used for improving public health professionals' ability to detect disease outbreaks faster than traditional methods and to enhance outbreak response. A social media work group, consisting of surveillance practitioners, academic researchers, and other subject matter experts convened by the International Society for Disease Surveillance, conducted a systematic primary literature review using the PRISMA framework to identify research, published through February 2013, answering either of the following questions: Can social media be integrated into disease surveillance practice and outbreak management to support and improve public health?Can social media be used to effectively target populations, specifically vulnerable populations, to test an intervention and interact with a community to improve health outcomes?Examples of social media included are Facebook, MySpace, microblogs (e.g., Twitter, blogs, and discussion forums. For Question 1, 33 manuscripts were identified, starting in 2009 with topics on Influenza-like Illnesses (n = 15, Infectious Diseases (n = 6, Non-infectious Diseases (n = 4, Medication and Vaccines (n = 3, and Other (n = 5. For Question 2, 32 manuscripts were identified, the first in 2000 with topics on Health Risk Behaviors (n = 10, Infectious Diseases (n = 3, Non-infectious Diseases (n = 9, and Other (n = 10.The literature on the use of social media to support public health practice has identified many gaps and biases in current knowledge. Despite the potential for success identified in exploratory studies, there are limited studies on interventions and little use of social media in practice. However, information gleaned from the articles demonstrates the effectiveness of social media in supporting and improving public health and in identifying target populations for intervention. A primary recommendation resulting from the review

  5. Cancer Survivors in the United States: A Review of the Literature and a Call to Action

    Manuel Valdivieso, Ann M. Kujawa, Tisha Jones, Laurence H. Baker

    2012-01-01

    Full Text Available Background: The number of cancer survivors in the U.S. has increased from 3 million in 1971, when the National Cancer Act was enacted, to over 12 million today. Over 70% of children affected by cancer survive more than 10 years, and most are cured. Most cancer survivors are adults, with two-thirds of them 65 years of age or older and two-thirds alive at five years. The most common cancer diagnoses among survivors include breast, prostate and colorectal cancers. This review was conducted to better appreciate the challenges associated with cancer survivors and the opportunities healthcare providers have in making a difference for these patients.Methods: Comprehensive review of literature based on PubMed searches on topics related to cancer survivorship, and associated physical, cognitive, socio-economic, sexual/behavioral and legal issues.Results: At least 50% of cancer survivors suffer from late treatment-related side effects, often including physical, psychosocial, cognitive and sexual abnormalities, as well as concerns regarding recurrence and/or the development of new malignancies. Many are chronic in nature and some are severe and even life-threatening. Survivors also face issues involving lack of appropriate health maintenance counseling, increased unemployment rate and workplace discrimination.Conclusions: Advances in the diagnosis and treatment of cancer will lead to more survivors and better quality of life. However, tools to recognize potentially serious long-lasting side effects of cancer therapy earlier in order to treat and/or prevent them must be developed. It is incumbent upon our health care delivery systems to make meeting these patients' needs a priority.

  6. Bacillus thuringiensis: mechanism of action, resistance, and new applications: a review.

    Melo, André Luiz de Almeida; Soccol, Vanete Thomaz; Soccol, Carlos Ricardo

    2016-01-01

    Since the first report by Ishiwata in 1902 of a Bombyx mori infection, followed by the description by Berliner, Bacillus thuringiensis (Bt) has become the main microorganism used in biological control. The application of Bt to combat invertebrates of human interest gained momentum with the growing demand for food free of chemical pesticides and with the implementation of agriculture methods that were less damaging to the environment. However, the mechanisms of action of these products have not been fully elucidated. There are two proposed models: the first is that Bt causes an osmotic imbalance in response to the formation of pores in a cell membrane, and the second is that it causes an opening of ion channels that activate the process of cell death. There are various ways in which Bt resistance can develop: changes in the receptors that do not recognize the Cry toxin, the synthesis of membrane transporters that eliminate the peptides from the cytosol and the development of regulatory mechanisms that disrupt the production of toxin receptors. Besides the potential for formulation of biopesticides and the use in developing genetically modified cultivars, recent studies with Bt have discussed promising applications in other branches of science. Chitinase, an enzyme that degrades chitin, increases the efficiency of Bt insecticides, and there has been of increasing interest in the industry, given that its substrate is extremely abundant in nature. Another promising field is the potential for Bt proteins to act against cancer cells. Parasporins, toxins of Bt that do not have an entomopathogenic effect, have a cytotoxic effect on the cells changed by some cancers. This demonstrates the potential of the microorganism and new opportunities opening for future applications. PMID:25264571

  7. India's draft nuclear doctrine

    India's draft nuclear doctrine and its nuclear and missile testing are a response to recent international, regional and domestic developments. Nehru's policy of nuclear disarmament, non-discriminatory international arrangements and unilateral restraint has been overturned in favour of self-reliant security and negotiated nuclear restraints. The draft nuclear doctrine is aimed at transparency and formalization of existing capacities. It is anchored in the United Nations Charter, based on the legitimacy of self-defence and espouses minimum nuclear deterrence. After the launching of Pokhran II, the debate in India has been settled on weaponization and deployment. The doctrine is not country-specific with respect to threat perceptions, but the author posits that the long-term focus is on China and the short-term on Pakistan. The doctrine emphasizes civilian command and control. India's decision to test incurred diplomatic and other economic costs, but afforded new opportunities for the country to assert itself militarily and politically in Asia and in the world. There were no diplomatic costs in issuing the draft nuclear doctrine, but the author estimates the economic costs of a full-blown (triad) Indian nuclear deterrent. (author)

  8. Replacement Nuclear Research Reactor. Supplement to Draft Environmental Impact Statement. Volume 3

    NONE

    1999-01-01

    The Draft Environmental Impact Statement for a replacement research reactor at Lucas Heights, was available for public examination and comment for some three months during 1998. A Supplement to the Draft Environmental Impact Statement (Draft EIS) has been completed and was lodged with Environment Australia on 18 January 1999. The Supplement is an important step in the overall environmental assessment process. It reviews submissions received and provides the proponent`s response to issues raised in the public review period. General issues extracted from submissions and addressed in the Supplement include concern over liability issues, Chernobyl type accidents, the ozone layer and health issues. Further studies, relating to issues raised in the public submission process, were undertaken for the Supplementary EIS. These studies confirm, in ANSTO`s view, the findings of the Draft EIS and hence the findings of the Final EIS are unchanged from the Draft EIS

  9. Replacement Nuclear Research Reactor. Supplement to Draft Environmental Impact Statement. Volume 3

    The Draft Environmental Impact Statement for a replacement research reactor at Lucas Heights, was available for public examination and comment for some three months during 1998. A Supplement to the Draft Environmental Impact Statement (Draft EIS) has been completed and was lodged with Environment Australia on 18 January 1999. The Supplement is an important step in the overall environmental assessment process. It reviews submissions received and provides the proponent's response to issues raised in the public review period. General issues extracted from submissions and addressed in the Supplement include concern over liability issues, Chernobyl type accidents, the ozone layer and health issues. Further studies, relating to issues raised in the public submission process, were undertaken for the Supplementary EIS. These studies confirm, in ANSTO's view, the findings of the Draft EIS and hence the findings of the Final EIS are unchanged from the Draft EIS

  10. [Review of the effects of mindfulness meditation on mental and physical health and its mechanisms of action].

    Ngô, Thanh-Lan

    2013-01-01

    Interventions based on mindfulness have become increasingly popular. This article reviews the empirical literature on its effects on mental and physical health, discusses presumed mechanisms of action as well as its proposed neurobiological underpinning. Mindfulness is associated with increased well-being as well as reduced cognitive reactivity and behavioral avoidance. It seems to contribute to enhance immune functions, diminish inflammation, diminish the reactivity of the autonomic nervous system, increase telomerase activity, lead to higher levels of plasmatic melatonin and serotonin. It enhances the quality of life for patients suffering from chronic pain, fibromylagia and HIV infection. It facilitates adaptation to the diagnosis of cancer and diabetes. It seems to lead to symptomatic improvement in irritable bowel syndrome, chronic fatigue syndrome, hot flashes, insomnia, stress related hyperphagia. It diminishes craving in substance abuse. The proposed mechanism of action are enhanced metacognitive conscience, interoceptive exposure, experiential acceptance, self-management, attention control, memory, relaxation. Six mechanism of actions for which neurological underpinnings have been published are: attention regulation (anterior cingulate cortex), body awareness (insula, temporoparietal junction), emotion regulation (modulation of the amygdala by the lateral prefrontal cortex), cognitive re-evaluation (activation of the dorsal medial prefrontal cortex or diminished activity in prefrontal regions), exposure/extinction/reconsolidation (ventromedial prefrontal cortex, hippocampus, amygdala) and flexible self-concept (prefrontal median cortex, posterior cingulated cortex, insula, temporoparietal junction). The neurobiological effects of meditation are described. These are: (1) the deactivation of the default mode network that generates spontaneous thoughts, contributes to the maintenance of the autobiographical self and is associated with anxiety and depression

  11. ERG and GRG review of the draft of ''preliminary test plan for in situ testing from an exploratory shaft in salt - October 1983''

    The Engineering Review Group (ERG) and Geologic Review Group (GRG) were established by the Office of Nuclear Waste Isolation (ONWI) to help evaluate engineering- and geologic-related issues in the US Department of Energy's nuclear waste repository program. The January 1984 meeting of the ERG and GRG reviewed the In Situ Test Plan (ISTP) titled ''Preliminary Test Plan for In Situ Testing From an Exploratory Shaft in Salt - October 1983.'' This report documents the ERG's and GRG's comments and recommendations on this subject and the ONWI responses to the specific points raised by the ERG and GRG. 6 refs., 2 figs., 1 tab

  12. Mini-Review: Novel Therapeutic Strategies to Blunt Actions of Pneumolysin in the Lungs

    Martin Leustik

    2013-07-01

    Full Text Available Severe pneumonia is the main single cause of death worldwide in children under five years of age. The main etiological agent of pneumonia is the G+ bacterium Streptococcus pneumoniae, which accounts for up to 45% of all cases. Intriguingly, patients can still die days after commencing antibiotic treatment due to the development of permeability edema, although the pathogen was successfully cleared from their lungs. This condition is characterized by a dramatically impaired alveolar epithelial-capillary barrier function and a dysfunction of the sodium transporters required for edema reabsorption, including the apically expressed epithelial sodium channel (ENaC and the basolaterally expressed sodium potassium pump (Na+-K+-ATPase. The main agent inducing this edema formation is the virulence factor pneumolysin, a cholesterol-binding pore-forming toxin, released in the alveolar compartment of the lungs when pneumococci are being lysed by antibiotic treatment or upon autolysis. Sub-lytic concentrations of pneumolysin can cause endothelial barrier dysfunction and can impair ENaC-mediated sodium uptake in type II alveolar epithelial cells. These events significantly contribute to the formation of permeability edema, for which currently no standard therapy is available. This review focuses on discussing some recent developments in the search for the novel therapeutic agents able to improve lung function despite the presence of pore-forming toxins. Such treatments could reduce the potentially lethal complications occurring after antibiotic treatment of patients with severe pneumonia.

  13. Subcutaneous IgG in immune-mediate diseases: proposed mechanisms of action and literature review.

    Danieli, Maria Giovanna; Gelardi, Chiara; Pedini, Veronica; Moretti, Romina; Gabrielli, Armando; Logullo, Francesco

    2014-12-01

    Intravenous immunoglobulin (IVIg) constitutes a relevant treatment option in various immune-mediated disorders, such as chronic inflammatory neuropathies and idiopathic inflammatory myopathies (IIM). Several advantages are linked to IVIg immunomodulatory and steroid sparing effects and to the possibility to withdraw the immunosuppressant therapy. However, the use of IVIg is not always easy to manage. It is associated with the need of an intravenous route of administration, high costs, and the risk of serious systemic adverse effects. More recently, the subcutaneous administration of immunoglobulin (SCIg) has been used in immunological practice as an alternative to IVIg, administered at lower dosages and more frequent intervals. This results in higher and more stable IgG serum levels and may prevent end-of-dose reduction and adverse effects caused by sudden IgG serum elevation. Moreover, the use of SCIg is more feasible, patient-friendly and cost-effective compared to the intravenous administration. In this context we compared IVIg and SCIg long term efficacy in the treatment of chronic inflammatory neuropathies and IIM, by reviewing the current literature and reporting the data obtained from our clinical experience about the use of SCIg in patients with myositis. We also described the most recent evidence on the immunomodulatory role of immunoglobulin, the pharmacokinetic properties of SCIg compared to the IVIg treatment, and the consequent clinical, laboratory and immunological implications. PMID:25172241

  14. Anthocyanins in obesity-associated thrombogenesis: a review of the potential mechanism of action.

    Thompson, Kiara; Pederick, Wayne; Santhakumar, Abishek Bommannan

    2016-05-18

    Platelet dysfunction, oxidative stress and dyslipidemia are important contributors to pro-thrombotic progression particularly in obese and hyper-cholesterolemic populations. Becoming an increasingly widespread endemic, obesity causes a dysfunction in the metabolic system by initiating endothelial dysfunction; increasing free radical production; lipid peroxidation; platelet hyperactivity and aggregation; thereby accelerating thrombogenesis. In the event of increased free radical generation under pro-thrombotic conditions, antioxidants act as scavengers in reducing physiological oxidative stress; free radical-mediated thrombosis and hemostatic function. Anthocyanin, a subclass of the polyphenol family flavonoids has been shown to exhibit anti-dyslipidemic and anti-thrombotic properties by virtue of its antioxidant activity. Current anti-platelet/coagulant therapeutics target specific receptor pathways to relieve the extent of dysfunction and plaque acceleration in pro-thrombotic individuals. Though effective, they have been associated with high bleeding risk and increased response variability. The following review focuses on the potential role of natural dietary anthocyanins in targeting simultaneous mechanistic pathways in alleviating platelet activation, dyslipidemia, and oxidative stress-associated thrombus acceleration in obese pro-thrombotic populations. PMID:27043127

  15. Propolis: a review of its anti-inflammatory and healing actions

    A. F. N. Ramos

    2007-01-01

    Full Text Available Tissue healing is an adaptive biological response by which the organism repairs damaged tissue. The initial stage of healing is represented by an acute inflammatory reaction, in which inflammatory cells migrate to damaged tissue and phagocyte debris. At a later stage, fibroblasts and endothelial cells proliferate and generate a scar. The occurrence of inflammatory processes and healing imperfections have been a concern for hundreds of years, especially for individuals with healing difficulties, such as diabetics and carriers of peripheral circulation deficiencies. A wide variety of natural products have been used as anti-inflammatory and healing agents, with propolis being a remarkable option. Propolis has been used in popular medicine for a very long time; however, it is not a drug intended for all diseases. Currently, the determination of quality standards of propolis-containing products is a major problem due to their varying pharmacological activities and chemical compositions. The aim of this review is to discuss the use of propolis with emphasis on its anti-inflammatory and healing properties.

  16. Safety and health in forest harvesting operations. Diagnosis and preventive actions. A review.

    P. Albizu-Urionabarrenetxea

    2013-12-01

    Full Text Available Aim of study: to review the present state of the art in relation to the main labour risks and the most relevant results of recent studies evaluating the safety and health conditions of the forest harvesting work and better ways to reduce accidents.Area of study: It focuses mainly on developed Countries, where the general concern about work risks prevention, together with the complex idiosyncrasy of forest work in forest harvesting operations, has led to a growing interest from the forest scientific and technical community.Material and Methods: The main bibliographic and Internet references have been identified using common reference analysis tools. Their conclusions and recommendations have been comprehensively summarized.Main results: Collection of the principal references and their most important conclusions relating to the main accident risk factors, their causes and consequences, the means used towards their prevention, both instrumental as well as in the aspects of training and business management, besides the influence of the growing mechanization of logging operations on those risks.Research highlights: Accident risk is higher in forest harvesting than in most other work sectors, and the main risk factors such as experience, age, seasonality, training, protective equipment, mechanization degree, etc. have been identified and studied.   The paper summarizes some relevant results, one of the principal being that the proper entrepreneurial risk management is a key factor leading to the success in minimizing labour risks.Key words: labour risk; forestry; accident rates; preventive measures; entrepreneurial risk management.

  17. Safety and health in forest harvesting operations. Diagnosis and preventive actions. A review

    Albizu-Urionabarrenetxea, P. M.; Tolosana-Esteban, E.; Roman-Jordan, E.

    2013-07-01

    Aim of study: to review the present state of the art in relation to the main labour risks and the most relevant results of recent studies evaluating the safety and health conditions of the forest harvesting work and better ways to reduce accidents. Area of study: It focuses mainly on developed Countries, where the general concern about work risks prevention, together with the complex idiosyncrasy of forest work in forest harvesting operations, has led to a growing interest from the forest scientific and technical community. Material and Methods: The main bibliographic and Internet references have been identified using common reference analysis tools. Their conclusions and recommendations have been comprehensively summarized. Main results: Collection of the principal references and their most important conclusions relating to the main accident risk factors, their causes and consequences, the means used towards their prevention, both instrumental as well as in the aspects of training and business management, besides the influence of the growing mechanization of logging operations on those risks. Research highlights: Accident risk is higher in forest harvesting than in most other work sectors, and the main risk factors such as experience, age, seasonality, training, protective equipment, mechanization degree, etc. have been identified and studied. The paper summarizes some relevant results, one of the principal being that the proper entrepreneurial risk management is a key factor leading to the success in minimizing labour risks. (Author)

  18. PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Insulin action and lipotoxicity in the development of polycystic ovary syndrome: A review.

    Faubert, J; Battista, M-C; Baillargeon, J-P

    2016-05-01

    Polycystic ovary syndrome (PCOS) is a common condition affecting women of reproductive age. This disorder is characterized by hyperandrogenism and anovulation and is frequently associated with comorbidities such as infertility, metabolic syndrome, type 2 diabetes, and cardiovascular risk factors. Although the causes of PCOS are unknown, this review focuses on the most accepted theory involving insulin action but will also elaborate on a novel concept: the role of lipotoxicity in the development of androgen overproduction, in addition to its known role in insulin resistance. This review will also shed a spotlight on 2 drugs that target lipotoxicity and are, therefore, known or promising for the treatment of PCOS manifestations: peroxisome proliferator-activated receptor γ and angiotensin II type 2 receptor agonists. This paper, therefore, emphasizes the need to further explore the pathophysiology of PCOS and particularly the role of lipotoxicity. Indeed, this new mechanism deserves attention to develop therapeutic approaches that will directly target the root of this condition and not only bandage its associated consequences. PMID:27285677

  19. The sunk cost effect across species: A review of persistence in a course of action due to prior investment.

    Magalhães, Paula; Geoffrey White, K

    2016-05-01

    The sunk cost effect is the bias or tendency to persist in a course of action due to prior investments of effort, money or time. At the time of the only review on the sunk cost effect across species (Arkes & Ayton, 1999), research with nonhuman animals had been ecological in its nature, and the findings about the effect of past investments on current choice were inconclusive. However, in the last decade a new line of experimental laboratory-based research has emerged with the promise of revolutionizing the way we approach the study of the sunk cost effect in nonhumans. In the present review we challenge Arkes and Ayton's conclusion that the sunk cost effect is exclusive to humans, and describe evidence for the sunk cost effect in nonhuman animals. By doing so, we also challenge the current explanations for the sunk cost effect in humans, as they are not applicable to nonhumans. We argue that a unified theory is called for, because different independent variables, in particular, investment amount, have the same influence on the sunk cost effect across species. Finally, we suggest possible psychological mechanisms shared across different species, contrast and depreciation, that could explain the sunk cost effect. PMID:27151560

  20. {A Review of Working Group 2 (Advanced Terrestrial Systems) of the COST 296 Action}

    Warrington, E. M.; Tulunay, E.

    2009-04-01

    E.M. Warrington, E. Tulunay, N.M. Abbasi, J. Azevedo, L. Bertel, A. Bourdillon, E. Benito, C. Bianchi, A. Casimiro, L. Economou, Y. Erhel, S.M. Feeney, S.D. Gunashekar, H. Haralambous, D. Lemur, F. Marie, J.P. Monilie, M. Muriuki, M. Oger M. Pietrella, V. Rannou, H. Rothkaehl, S. Saillant, S. Salous, O. Sari, A.J. Stocker, H.J. Strangeways, Y. Tulunay and N.Y. Zaalov This paper deals with the research undertaken during the COST 296 Action in Working Group 2 on Advanced Terrestrial Systems. The Working Group comprised three work packages covering various topics: Radar and Radiolocation, HF/MF Communications, and Spectrum Management. Results from this Working Group are presented in this paper, and may be summarised as follows. Aspects of HF propagation The propagation characteristics of radio signals are important parameters to consider when designing and operating radio systems. From the point of view Working Group 2 of the COST-296 Action, interest lies with effects associated with propagation via the ionosphere of signals within the HF band. Several aspects were covered: The directions of arrival and times of flight of signals received over a path oriented along the trough have been examined and several types of propagation effects identified. Of particular note, combining the HF observations with satellite measurements has identified the presence of irregularities within the floor of the trough that result in propagation displaced from the great circle direction. An understanding of the propagation effects that result in deviations of the signal path from the great circle direction are of particular relevance to the operation of HF radiolocation systems. Inclusion of the results from the above mentioned measurements into a propagation model of the northerly ionosphere (i.e. those regions of the ionosphere located poleward of, and including, the mid-latitude trough) and the use of this model to predict the coverage expected from transmitters where the signals

  1. 75 FR 67993 - Hydropower Resource Assessment at Existing Reclamation Facilities-Draft Report

    2010-11-04

    ... Bureau of Reclamation Hydropower Resource Assessment at Existing Reclamation Facilities--Draft Report... Bureau of Reclamation has made available for public review and comment the ``Hydropower Resource... and technical potential for hydropower development at existing Bureau of Reclamation...

  2. 75 FR 26220 - Public Utility District No. 1 of Snohomish County, WA; Notice of Availability of Draft...

    2010-05-11

    ... project, with appropriate environmental protective measures, would not constitute a major federal action.... Department of Agriculture, Forest Service. Staff prepared a draft environmental assessment (EA), which... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY...

  3. Draft 1992 Resource Program : Technical Report.

    United States. Bonneville Power Administration.

    1992-01-01

    The 1992 Resource Program will propose actions to meet future loads placed on the Bonneville Power Administration (BPA). It will also discuss and attempt to resolve resource-related policy issues. The Resource Program assesses resource availability and costs, and analyzes resource requirements and alternative ways of meeting those requirements through both conservation and generation resources. These general resource conclusions are then translated to actions for both conservation and generation. The Resource Program recommends budgets for the Office of Energy Resources for Fiscal Years (FY) 1994 and 1995. BPA's Resource Program bears directly on an important BPA responsibility: the obligation under the Northwest Power Act{sup 3} to meet the power requirements of public and private utility and direct service industrial (DSI) customers according to their contractual agreements. BPA's Draft 1992 Resource Program is contained in four documents: (1) 1992 Resource Program Summary; (2) Technical Report; (3) Technical Assumptions Appendix; and, (4) Conservation Implementation Plan. This volume is the Draft 1992 Resource Program Technical Report, a comprehensive document that provides supporting data and analyses for Resource Program recommendations.

  4. Draft 1992 Resource Program : Technical Report.

    United States. Bonneville Power Administration.

    1992-01-01

    The 1992 Resource Program will propose actions to meet future loads placed on the Bonneville Power Administration (BPA). It will also discuss and attempt to resolve resource-related policy issues. The Resource Program assesses resource availability and costs, and analyzes resource requirements and alternative ways of meeting those requirements through both conservation and generation resources. These general resource conclusions are then translated to actions for both conservation and generation. The Resource Program recommends budgets for the Office of Energy Resources for Fiscal Years (FY) 1994 and 1995. BPA`s Resource Program bears directly on an important BPA responsibility: the obligation under the Northwest Power Act{sup 3} to meet the power requirements of public and private utility and direct service industrial (DSI) customers according to their contractual agreements. BPA`s Draft 1992 Resource Program is contained in four documents: (1) 1992 Resource Program Summary; (2) Technical Report; (3) Technical Assumptions Appendix; and, (4) Conservation Implementation Plan. This volume is the Draft 1992 Resource Program Technical Report, a comprehensive document that provides supporting data and analyses for Resource Program recommendations.

  5. Draft WNP-1 [Washington Nuclear Plant] and -3 study: 1987 resource strategy

    With this study Bonneville seeks to conclude whether WNP-1 and -3 should be preserved, terminated, or completed on a fixed construction schedule. Bonneville has completed an intensive review and analysis of issues related to this question. Bonneville's draft study conclusion is that preserving both WNP-1 and -3 is the most prudent course of action in the short run, pending the resolution of several critical factors. This conclusion is based on the following key study findings. Bonneville found that, economically, continued preservation is the lower-risk alternative. Termination creates the risk that the region would have to eventually build new coal plants, costing over $2 billion more in present value than completing WNP-1 and -3. Alternatively, preservation creates the smaller risk that preservation costs, amounting to $150 million in present value, will be spent over the next 14 years on projects that turn out not to be needed

  6. 76 FR 62434 - HUD Draft Environmental Justice Strategy

    2011-10-07

    ... URBAN DEVELOPMENT HUD Draft Environmental Justice Strategy AGENCY: Office of the Sustainable Housing and... Environmental Justice Strategy for review and comment. DATES: Comment Due Date: November 14, 2011. Comments may... Strategy (EJ Strategy). HUD's EJ Strategy is a four-year plan to address environmental justice concerns...

  7. Pipe drafting and design

    Parisher, Roy A

    2011-01-01

    Pipe Drafting and Design, Third Edition provides step-by-step instructions to walk pipe designers, drafters, and students through the creation of piping arrangement and isometric drawings. It includes instructions for the proper drawing of symbols for fittings, flanges, valves, and mechanical equipment. More than 350 illustrations and photographs provide examples and visual instructions. A unique feature is the systematic arrangement of drawings that begins with the layout of the structural foundations of a facility and continues through to the development of a 3-D model. Advanced chapters

  8. 75 FR 62433 - Notice of Public Hearings and the Availability of a Draft Programmatic Environmental Impact...

    2010-10-08

    ... Notice of Public Hearings and the Availability of a Draft Programmatic Environmental Impact Statement/Overseas Environmental Impact Statement (PEIS/OEIS) AGENCY: National Science Foundation. ACTION: Notice of... agencies. The purpose of the Proposed Action is to fund the investigation of the geology and geophysics...

  9. Maintenance approaches and practices in selected foreign nuclear power programs and other US industries: Review and lessons learned: Draft report for comment

    The Commission recently published a Notice of Proposed Rulemaking on Maintenance of Nuclear Power Plants spelling out NRC's expectations in maintenance. In preparing the proposed rule, the NRC reviewed maintenance practices in other countries and considered maintenance approaches in other industries in this country. As a result of the examination of the benefits of various regulatory approaches, it is concluded that a regulatory approach similar to that adopted by the Federal Aviation Administration is most appropriate for NRC's proposed rulemaking. As a result of the review of maintenance practices, it is concluded that certain practices in the following areas have been found to contribute significantly to effective maintenance: (1) systems approach; (2) effectiveness monitoring; (3) technician qualifications and motivation; and (4) maintenance organization. 37 refs

  10. 46 CFR 167.55-1 - Draft marks and draft indicating systems.

    2010-10-01

    ... NAUTICAL SCHOOL SHIPS Special Markings Required § 167.55-1 Draft marks and draft indicating systems. (a... are of uniform height equal to the vertical spacing between consecutive marks. (f) Draft marks must...

  11. Weldon Spring Site Remedial Action Project: Report from the DOE voluntary protection program onsite review, November 17-21, 1997

    This report summarizes the Department of Energy Voluntary Protection Program (DOE-VPP) Review Team's findings from the five-day onsite evaluation of the Weldon Spring Site Remedial Action Project (WSSRAP), conducted November 17--21, 1997. The site was evaluated against the program requirements contained in ''US Department of Energy Voluntary Protection Program, Part 1: Program Elements'' to determine its success in implementing the five tenets of DOE-VPP. DOE-VPP consists of three programs, with names and functions similar to those in OSHA's VPP. These programs are STAR, MERIT, and DEMONSTRATION. The STAR program is the core of DOE-VPP. The program is aimed at truly outstanding protectors of employee safety and health. The MERIT program is a steppingstone for contractors and subcontractors that have good safety and health programs but need time and DOE guidance to achieve STAR status. The DEMONSTRATION program is rarely used; it allows DOE to recognize achievements in unusual situations about which DOE needs to learn more before determining approval requirements for the STAR status

  12. Weldon Spring Site Remedial Action Project: Report from the DOE voluntary protection program onsite review, November 17--21, 1997

    NONE

    1998-01-28

    This report summarizes the Department of Energy Voluntary Protection Program (DOE-VPP) Review Team`s findings from the five-day onsite evaluation of the Weldon Spring Site Remedial Action Project (WSSRAP), conducted November 17--21, 1997. The site was evaluated against the program requirements contained in ``US Department of Energy Voluntary Protection Program, Part 1: Program Elements`` to determine its success in implementing the five tenets of DOE-VPP. DOE-VPP consists of three programs, with names and functions similar to those in OSHA`s VPP. These programs are STAR, MERIT, and DEMONSTRATION. The STAR program is the core of DOE-VPP. The program is aimed at truly outstanding protectors of employee safety and health. The MERIT program is a steppingstone for contractors and subcontractors that have good safety and health programs but need time and DOE guidance to achieve STAR status. The DEMONSTRATION program is rarely used; it allows DOE to recognize achievements in unusual situations about which DOE needs to learn more before determining approval requirements for the STAR status.

  13. Staff review of 'Radioecological assessment of the Wyhl nuclear power plant': Analysis of the report prepared by the University of Heidelberg, West Germany. Draft summary report

    The Heidelberg Report presents an assessment of the environmental radiological impact of a proposed pressurized-water reactor to be built near Wyhl, West Germany. The assessment is based largely on mathematical models that are used to calculate doses to humans in the area surrounding a reactor site and describe the movement of radioactive materials in the environment. These are the same mathematical models that are used by the U.S. Nuclear Regulatory Commission (NRC) in licensing reactors in the United States. The NRC uses these models to make sure that any radiation exposure due to a reactor is far below national and international recommended 'safe' levels, as well as below natural radiation levels. The NRC staff reviewed certain parts of the Heidelberg Report because the report implied that the NRC may be substantially underestimating doses to individuals living near nuclear power plants by using incorrect values for parameters in the mathematical models. Although the Heidelberg Report assessment is based largely on environmental models described in four NRC Regulatory Guides, the NRC staff's review of the Heidelberg Report indicates that the Heidelberg authors used values for some model parameters that are too high

  14. 78 FR 26026 - Draft Plan for Development of the Integrated Science Assessment for Nitrogen Oxides-Health Criteria

    2013-05-03

    ...The U.S. EPA is announcing the availability of the ``Draft Plan for Development of the Integrated Science Assessment for Nitrogen Oxides--Health Criteria.'' The draft document was prepared by the National Center for Environmental Assessment (NCEA) within EPA's Office of Research and Development as part of the review of the primary (health-based) national ambient air quality standards (NAAQS)......

  15. 75 FR 39493 - United States Patent and Trademark Office Draft Strategic Plan for FY 2010-2015

    2010-07-09

    ... administration and leadership of the agency is a revision of the FY 2007-2012 strategic plan. The USPTO's current... United States Patent and Trademark Office United States Patent and Trademark Office Draft Strategic Plan...) draft strategic plan for fiscal years (FY) 2010-2015 is available for public review and comment....

  16. American Samoa Energy Action Plan

    Haase, Scott [National Renewable Energy Lab. (NREL), Golden, CO (United States); Esterly, Sean [National Renewable Energy Lab. (NREL), Golden, CO (United States); Herdrich, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bodell, Tim [National Renewable Energy Lab. (NREL), Golden, CO (United States); Visser, Charles [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-08-01

    Describes the five near-term strategies selected by the American Samoa Renewable Energy Committee (ASREC) during action planning workshops conducted in May 2013, and outlines the actions being taken to implement those strategies. Each option is tied to a priority identified in the earlier draft American Samoa Strategic Energy Plan as being an essential component of reducing American Samoa'spetroleum energy consumption. The actions described for each strategy provide a roadmap to facilitate the implementation of each strategy. This document is intended to evolve along with the advancement of the projects, and will be updated to reflect progress.

  17. Theory of reasoned action and theory of planned behavior-based dietary interventions in adolescents and young adults: a systematic review

    Hackman CL; Knowlden AP

    2014-01-01

    Christine L Hackman, Adam P KnowldenDepartment of Health Science, The University of Alabama, Tuscaloosa, AL, USABackground: Childhood obesity has reached epidemic proportions in many nations around the world. The theory of planned behavior (TPB) and the theory of reasoned action (TRA) have been used to successfully plan and evaluate numerous interventions for many different behaviors. The aim of this study was to systematically review and synthesize TPB and TRA-based dietary behavior interven...

  18. Tadalafil for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a review of clinical data in Asian men and an update on the mechanism of action

    Yokoyama, Osamu; Igawa, Yasuhiko; Takeda, Masayuki; Yamaguchi, Takafumi; Murakami, Masahiro; Viktrup, Lars

    2015-01-01

    Tadalafil, a phosphodiesterase type 5 (PDE5) inhibitor, is approved worldwide for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia (BPH-LUTS). The purpose of this narrative review is to summarize the clinical data on tadalafil 5 mg once-daily, primarily focusing on Asian men with BPH-LUTS, and to update the current understanding of the mechanism of action underlying PDE5 inhibition. Findings from studies have demonstrated that PDE5 is highly expressed in...

  19. Evaluation of Worktext in Mechanical Drafting

    Erich D. Cruz

    2015-01-01

    This study aimed to evaluate Worktext in Drafting Technology 4 (Mechanical Drafting) for Bachelor of Technology (BT) major in Drafting Technology. It was conducted at University of Rizal System with twenty Drafting and Mechanical Technology professors as respondents. The study used the descriptive evaluative method to describe and evaluate the developed Worktext in DT 4 using the questionnaire-checklist in gathering data. They were asked to evaluate the worktext through the following: objecti...

  20. Draft Transportaion Business Plan

    The Office of Civilian Radioactive Waste Management (OCRWM) is responsible for establishing a transportation system to support shipment of spent fuel and high-level radioactive waste to repositories and storage facilities developed under the Nuclear Waste Policy Act of 1982 (NWPA). An element that assists in fulfilling that responsibility is a business plan for acquiring and operating a transportation system. The Draft Transportation Business Plan is an interim step in the process of procuring the transportation system. It sets the context for business strategy decisions by providing pertinent background information, describing the legislation and policies governing transportation under the NWPA, and with establishing the transportation system. It also serves as an instrument for initiating communication between OCRWM and other interested parties. Included in the docuument are strategies for procuring shipping casks and transportation support services. Additionally, in the spirit of the NWPA directive to utilize the private sector to the maximum extent possible, opportunities for business ventures are obvious throughout the system development cycle

  1. 32 CFR 989.19 - Draft EIS.

    2010-07-01

    ... impacts, and anyone else requesting the entire draft EIS (40 CFR 1502.19 and 1506.6). (2) The EPF sponsors... comments (40 CFR 1503.4). The EPF must incorporate in the Final EIS its responses to comments on the Draft... proponent in preparation of a preliminary draft EIS (PDEIS) (40 CFR 1502.9) based on the scope of...

  2. 49 CFR 229.61 - Draft system.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Draft system. 229.61 Section 229.61 Transportation... TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Draft System § 229.61 Draft system. (a) A.... Suspension System...

  3. Accelerating Cleanup: Focus on 2006. Discussion draft

    This executive summary addresses the activities associated with the National Transuranic (TRU) Program managed by the Carlsbad Area Office (CAO). The CAO programmatically reports to the Assistant Secretary for Environmental Management and receives administrative support through the Albuquerque Operations Office. The mission of the Carlsbad Area Office (CAO) is to protect human health and the environment by opening and operating the Waste Isolation Pilot Plant for site disposal of TRU waste and by establishing an effective system for management of TRU waste from generation to disposal. It includes personnel assigned to the CAO, the Waste Isolation Pilot Plant (WIPP) site operations, and other activities associated with the National TRU Program. The CAO develops and directs implementation of the program, while the DOE Headquarters establishes policy and guidelines. The CAO assesses compliance with the program guidance, as well as the commonality of activities and assumptions among all the sites. Since the development of the February 28, 1997, database used to develop this Discussion Draft, the opening of the WIPP facility for receipt of Contact Handled waste has been delayed from November 1997 to May 1998. This slippage is significant enough to require a change in the milestones and volumes included in the documents to be reviewed by our stakeholders. Changes have been incorporated into this Discussion Draft and its supporting Project Baseline Summaries (PBSs)

  4. Inferences about Action Engage Action Systems

    Taylor, Lawrence J.; Lev-Ari, Shiri; Zwaan, Rolf A.

    2008-01-01

    Verbal descriptions of actions activate compatible motor responses [Glenberg, A. M., & Kaschak, M. P. (2002). Grounding language in action. "Psychonomic Bulletin & Review, 9", 558-565]. Previous studies have found that the motor processes for manual rotation are engaged in a direction-specific manner when a verb disambiguates the direction of…

  5. Draft 1988 mission plan amendment

    This draft 1988 amendment to the Mission Plan for the Civilian Radioactive Waste Management Program has been prepared by the US Department of Energy (DOE). The purpose is to inform the Congress of the DOE's plans for implementing the provisions of the Nuclear Waste Policy Amendments Act of 1987 (P.L. 100-203) for the Civilian Radioactive Waste Management Program. This document is being submitted in draft form to Federal agencies, states, previously affected Indian Tribes, affected units of local government, and the public. After the consideration of comments, this amendment will be revised as appropriate and submitted to the Congress. 39 refs., 7 figs., 4 tabs

  6. Nanostructured materials for solid-state hydrogen storage: A review of the achievement of COST Action MP1103

    Callini, Elsa; Aguey-Zinsou, Kondo-Francois; Ahuja, Rajeev;

    2016-01-01

    In the framework of the European Cooperation in Science and Technology (COST) Action MP1103 Nanostructured Materials for Solid-State Hydrogen Storage were synthesized, characterized and modeled. This Action dealt with the state of the art of energy storage and set up a competitive and coordinated...... structure from bulk to thin film, nanoparticles and nanoconfined composites improved the hydrogen sorption properties and opened the perspective to new technological applications. Direct imaging of the hydrogenation reactions and in situ measurements under operando conditions have been carried out in these...

  7. Critical review of the national action plans (NAcP) of the EU stress tests on nuclear power plants

    reasons as TEPCO in Japan until Fukushima. The EU tried to respond to this ''new experience'' of Fukushima by conducting the stress tests and hoping that the results will lead to higher safety. This report investigated the result, the very concrete measures each nuclear safety authority will require its operators to implement and until which date. Transparency is another important tool to control nuclear risk; while ENSREG certainly recognizes this fact, not all national nuclear regulators and operators act accordingly to fulfil this need of higher transparency. It is evident that some countries treated this task rather as a formality or paperwork than a plant safety upgrade program. (The ENSREG peer review hopefully will insist on introducing additional measures to the national plans in those cases where the national regulator required less safety measures than the stress tests peer review recommended.) In general, there are different possibilities for operator and nuclear authority to remedy the shortcomings the stress tests revealed: - A quick response, but without any guarantee that the measures are sufficient (e.g. Wylfa, UK). - A comprehensive evaluation of possible hazards and protections measures, which will take more than ten years (e.g. Gravelines and Cattenom, France). - Business-as-usual, (e.g. Temelin, Czech Republic). The idea of the stress tests is more or less ignored. Instead the already ongoing measures are listed, major hardware improvement avoided. None of those possible variants increase the nuclear safety to an acceptable level. The very obvious solution - permanent shut down - needs to be considered and is in several cases the only safe option. This applies in particular to those plants where significant improvements cannot be achieved by the planned deployment of mobile equipment only or by having plants on the grid in the current status for many more years while evaluations and assessment are under preparation and again later backfittings would

  8. Critical review of the national action plans (NAcP) of the EU stress tests on nuclear power plants

    Becker, Oda; Lorenz, Patricia

    2013-04-15

    , very much as the same reasons as TEPCO in Japan until Fukushima. The EU tried to respond to this ''new experience'' of Fukushima by conducting the stress tests and hoping that the results will lead to higher safety. This report investigated the result, the very concrete measures each nuclear safety authority will require its operators to implement and until which date. Transparency is another important tool to control nuclear risk; while ENSREG certainly recognizes this fact, not all national nuclear regulators and operators act accordingly to fulfil this need of higher transparency. It is evident that some countries treated this task rather as a formality or paperwork than a plant safety upgrade program. (The ENSREG peer review hopefully will insist on introducing additional measures to the national plans in those cases where the national regulator required less safety measures than the stress tests peer review recommended.) In general, there are different possibilities for operator and nuclear authority to remedy the shortcomings the stress tests revealed: - A quick response, but without any guarantee that the measures are sufficient (e.g. Wylfa, UK). - A comprehensive evaluation of possible hazards and protections measures, which will take more than ten years (e.g. Gravelines and Cattenom, France). - Business-as-usual, (e.g. Temelin, Czech Republic). The idea of the stress tests is more or less ignored. Instead the already ongoing measures are listed, major hardware improvement avoided. None of those possible variants increase the nuclear safety to an acceptable level. The very obvious solution - permanent shut down - needs to be considered and is in several cases the only safe option. This applies in particular to those plants where significant improvements cannot be achieved by the planned deployment of mobile equipment only or by having plants on the grid in the current status for many more years while evaluations and assessment are under

  9. Analytics4Action Evaluation Framework: A Review of Evidence-Based Learning Analytics Interventions at the Open University UK

    Rienties, Bart; Boroowa, Avinash; Cross, Simon; Kubiak, Chris; Mayles, Kevin; Murphy, Sam

    2016-01-01

    There is an urgent need to develop an evidence-based framework for learning analytics whereby stakeholders can manage, evaluate, and make decisions about which types of interventions work well and under which conditions. In this article, we will work towards developing a foundation of an Analytics4Action Evaluation Framework (A4AEF) that is…

  10. External Peer Review Team Report for Corrective Action Unit 97: Yucca Flat/Climax Mine, Nevada National Security Site, Nye County, Nevada, Revision 0

    Marutzky, Sam J.; Andrews, Robert

    2015-01-01

    The peer review team commends the Navarro-Intera, LLC (N-I), team for its efforts in using limited data to model the fate of radionuclides in groundwater at Yucca Flat. Recognizing the key uncertainties and related recommendations discussed in Section 6.0 of this report, the peer review team has concluded that U.S. Department of Energy (DOE) is ready for a transition to model evaluation studies in the corrective action decision document (CADD)/corrective action plan (CAP) stage. The DOE, National Nuclear Security Administration Nevada Field Office (NNSA/NFO) clarified the charge to the peer review team in a letter dated October 9, 2014, from Bill R. Wilborn, NNSA/NFO Underground Test Area (UGTA) Activity Lead, to Sam J. Marutzky, N-I UGTA Project Manager: “The model and supporting information should be sufficiently complete that the key uncertainties can be adequately identified such that they can be addressed by appropriate model evaluation studies. The model evaluation studies may include data collection and model refinements conducted during the CADD/CAP stage. One major input to identifying ‘key uncertainties’ is the detailed peer review provided by independent qualified peers.” The key uncertainties that the peer review team recognized and potential concerns associated with each are outlined in Section 6.0, along with recommendations corresponding to each uncertainty. The uncertainties, concerns, and recommendations are summarized in Table ES-1. The number associated with each concern refers to the section in this report where the concern is discussed in detail.

  11. Drafting with Design in Mind

    Daugherty, Michael K.; Carter, Vinson

    2011-01-01

    Design and drafting are subjects long taught in technology education, and subjects that retain high status in the profession. Admittedly, since the initial publication of Standards for Technological Literacy in 2000, design has taken on a larger role and meaning in the technology education profession. However, design continues to be delivered…

  12. AGILE DRAFTING OF OUTSOURCING CONTRACTS

    Schlichter, Bjarne Rerup; Storgaard, Kristian

    2015-01-01

    several parallel tracks using different competencies. By the use of an illustrative case-study, this paper explores how scrum can be applied to enhance the process of drafting outsourcing contracts. The analysis indicates that the use of an agile method, such as Scrum, can be beneficial in this context...

  13. RCA annual report 1996. Draft

    In accordance with Article VII.4 of the Regional Co-operative Agreement for Research, Development and Training Related to Nuclear Science and Technology 1987 and extended in 1992, a draft report of activities for the calendar year 1996 is submitted

  14. Cognitive Style and Drafting Performance.

    Guster, Dennis

    1986-01-01

    The relationships between drafting performance and the cognitive style construct of field dependence/field independence are examined. The analysis revealed that the performance of the field-independent individual is likely to be superior to that of the field-dependent student. (Author/CT)

  15. 78 FR 47410 - General Management Plan, Draft Environmental Impact Statement, Gateway National Recreation Area...

    2013-08-05

    ... Recreation Area, New Jersey and New York AGENCY: National Park Service, Interior. ACTION: Notice of... Management Plan (GMP), Gateway National Recreation Area (Gateway), New York. The draft describes and analyzes... National Recreation Area, 210 New York Avenue, Staten Island, New York 10305 or telephone at (718)...

  16. 77 FR 52365 - Notice of Availability of the Draft Environmental Impact Statement for the Arkansas Valley...

    2012-08-29

    ... are analyzed in the Draft EIS: (1) Construct and operate the Arkansas Valley Conduit (AVC) and enter... and delivery purposes, the proposed actions are independent of each other. The AVC was authorized by... annual federal funding as necessary for constructing AVC, and included a cost sharing plan with...

  17. 76 FR 30175 - Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by...

    2011-05-24

    ... HUMAN SERVICES Food and Drug Administration (Formerly FDA-1999-D-0792) Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by Clinical Investigators; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA)...

  18. 77 FR 16990 - Notification of Submission to the Secretary of Agriculture of Two Draft Regulatory Documents...

    2012-03-23

    ... of Agriculture of Two Draft Regulatory Documents Under FIFRA AGENCY: Environmental Protection Agency (EPA). ] ACTION: Notification of submission to the Secretary of Agriculture. SUMMARY: This document... (FIFRA) that the EPA has forwarded to the Secretary of the United States Department of Agriculture...

  19. 78 FR 17708 - Endangered and Threatened Wildlife and Plants; Draft Revised Supplement to the Grizzly Bear...

    2013-03-22

    ... the Grizzly Bear Recovery Plan AGENCY: Fish and Wildlife Service, Interior. ACTION: Notice of document... availability of a draft Revised Supplement to the Grizzly Bear Recovery Plan. Specifically, this supplement..., Grizzly bears (Ursus arctos horribilis) are federally listed as threatened under the Endangered...

  20. 77 FR 71194 - Draft Guidance for Industry: Preclinical Assessment of Investigational Cellular and Gene Therapy...

    2012-11-29

    ... Investigational Cellular and Gene Therapy Products; Availability AGENCY: Food and Drug Administration, HHS. ACTION...). The product areas covered by this guidance are cellular therapy, gene therapy, therapeutic vaccination... Investigational Cellular and Gene Therapy Products,'' dated November 2012. The draft guidance document...

  1. 76 FR 30754 - Notice of Availability of the Draft Environmental Impact Statement: Riverside and Orange Counties...

    2011-05-26

    ...: Riverside and Orange Counties, CA AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice of... the Draft Environmental Impact Statement for a proposed highway project in Riverside and Orange... in Riverside and Orange Counties. The State Route 91 Corridor Improvement Project proposes to...

  2. 75 FR 54177 - Notice of Availability of Draft Environmental Impact Statement for the Tonopah Solar Energy...

    2010-09-03

    ...: 14X5017] Notice of Availability of Draft Environmental Impact Statement for the Tonopah Solar Energy Crescent Dunes Solar Energy Project, Nye County, NV AGENCY: Bureau of Land Management, Interior. ACTION... (EIS) for the Crescent Dunes Solar Energy Project, Nye County, Nevada, and by this Notice is...

  3. 77 FR 10753 - Draft Guidance for Industry: Food and Drug Administration Records Access Authority Under the...

    2012-02-23

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Food and Drug Administration Records Access Authority Under the Federal Food, Drug, and Cosmetic Act; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is...

  4. 78 FR 49271 - Draft Guidance for Industry on Frequently Asked Questions About Medical Foods; Second Edition...

    2013-08-13

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry on Frequently Asked Questions About Medical Foods; Second Edition; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA or we) is announcing the availability of the...

  5. 76 FR 34999 - Draft Guidance for Industry and Food and Drug Administration Staff; Establishing the Performance...

    2011-06-15

    ... Methicillin-Resistant Staphylococcus Aureus for Culture-Based Devices; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug...

  6. 76 FR 13396 - Notice of Availability of the Draft Environmental Impact Statement for the Mountaineer Commercial...

    2011-03-11

    ... Carbon Capture and Storage Project, Mason County, WV AGENCY: U.S. Department of Energy. ACTION: Notice of... Draft Environmental Impact Statement for the Mountaineer Commercial Scale Carbon Capture and Storage... Carbon Capture and Storage (CCS) Project (Mountaineer CCS II Project). AEP's proposed project...

  7. 77 FR 2514 - National Ocean Council-National Ocean Policy Draft Implementation Plan

    2012-01-18

    ... From the Federal Register Online via the Government Publishing Office COUNCIL ON ENVIRONMENTAL... Environmental Quality. ACTION: Notice of availability; request for comments. SUMMARY: On July 19, 2010... national economy, and are essential to public health and national security. The draft Implementation...

  8. 78 FR 11654 - Draft Guidance for Industry and Food and Drug Administration Staff; Providing Information About...

    2013-02-19

    ... Food, Drug, and Cosmetic Act; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice... Pediatric Uses of Medical Devices Under Section 515A of the Federal Food, Drug, and Cosmetic Act.'' FDA is... information required under the Federal Food, Drug, and Cosmetic Act (the FD&C Act). This draft guidance is...

  9. On the origins of human handedness and language: a comparative review of hand preferences for bimanual coordinated actions and gestural communication in nonhuman primates.

    Meguerditchian, Adrien; Vauclair, Jacques; Hopkins, William D

    2013-09-01

    Within the evolutionary framework about the origin of human handedness and hemispheric specialization for language, the question of expression of population-level manual biases in nonhuman primates and their potential continuities with humans remains controversial. Nevertheless, there is a growing body of evidence showing consistent population-level handedness particularly for complex manual behaviors in both monkeys and apes. In the present article, within a large comparative approach among primates, we will review our contribution to the field and the handedness literature related to two particular sophisticated manual behaviors regarding their potential and specific implications for the origins of hemispheric specialization in humans: bimanual coordinated actions and gestural communication. Whereas bimanual coordinated actions seem to elicit predominance of left-handedness in arboreal primates and of right-handedness in terrestrial primates, all handedness studies that have investigated gestural communication in several primate species have reported stronger degree of population-level right-handedness compared to noncommunicative actions. Communicative gestures and bimanual actions seem to affect differently manual asymmetries in both human and nonhuman primates and to be related to different lateralized brain substrates. We will discuss (1) how the data of hand preferences for bimanual coordinated actions highlight the role of ecological factors in the evolution of handedness and provide additional support the postural origin theory of handedness proposed by MacNeilage [MacNeilage [2007]. Present status of the postural origins theory. In W. D. Hopkins (Ed.), The evolution of hemispheric specialization in primates (pp. 59-91). London: Elsevier/Academic Press] and (2) the hypothesis that the emergence of gestural communication might have affected lateralization in our ancestor and may constitute the precursors of the hemispheric specialization for language. PMID

  10. Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: a review of the protective action of melatonin.

    Gultekin, Fatih; Hicyilmaz, Hicran

    2007-10-01

    This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage. PMID:17823789

  11. Renal deterioration caused by carcinogens as a consequence of free radical mediated tissue damage: a review of the protective action of melatonin

    Gultekin, Fatih; Hicyilmaz, Hicran [Suleyman Demirel University, School of Medicine, Department of Biochemistry, Isparta (Turkey)

    2007-10-15

    This brief review summarizes some of the publications that document the preventive role of melatonin in kidney damage caused by carcinogens such as 2-nitropropane, arsenic, carbon tetrachloride, nitrilotriacetic acid and potassium bromate. Numerous chemicals generate excessive free radicals that eventually induce renal worsening. Melatonin partially or totally prevents free radical mediated tissue damages induced by many carcinogens. Protective actions of melatonin against the harmful effects of carcinogens are believed to stem from its direct free radical scavenging and indirect antioxidant activities. Dietary or pharmacologically given melatonin may attenuate the oxidative stress, thereby mitigating the subsequent renal damage. (orig.)

  12. Negative-pressure wound therapy for management of diabetic foot wounds: a review of the mechanism of action, clinical applications, and recent developments

    Hasan, Muhammed Y.; Teo, Rachel; Nather, Aziz

    2015-01-01

    Negative-pressure wound therapy (NPWT) plays an important role in the treatment of complex wounds. Its effect on limb salvage in the management of the diabetic foot is well described in the literature. However, a successful outcome in this subgroup of diabetic patients requires a multidisciplinary approach with careful patient selection, appropriate surgical debridement, targeted antibiotic therapy, and optimization of healing markers. Evolving NPWT technology including instillation therapy, nanocrystalline adjuncts, and portable systems can further improve results if used with correct indications. This review article summarizes current knowledge about the role of NPWT in the management of the diabetic foot and its mode of action, clinical applications, and recent developments. PMID:26140663

  13. Constructing racial hierarchies of skill – Experiencing affirmative action in a South African organisation: A qualitative review

    Shanya Reuben; Shaida Bobat

    2014-01-01

    Orientation: Apartheid in South Africa constructed racial, economic, social and political segregation, the consequences of which are still experienced today. Government has made concerted efforts to ‘deracialise’ South Africa, most notably through affirmative action (AA) measures.Research purpose: This study aimed to explore employees’ social constructions of AA in a South African organisation.Motivation for the study: Research in this field focuses mostly on attitudinal perspectives of AA wi...

  14. Review of decision methodologies for evaluating regulatory actions affecting public health and safety. [Nuclear industry site selection

    Hendrickson, P.L.; McDonald, C.L.; Schilling, A.H.

    1976-12-01

    This report examines several aspects of the problems and choices facing the governmental decision maker who must take regulatory actions with multiple decision objectives and attributes. Particular attention is given to the problems facing the U.S. Nuclear Regulatory Commission (NRC) and to the decision attribute of chief concern to NRC, the protection of human health and safety, with emphasis on nuclear power plants. The study was undertaken to provide background information for NRC to use in refining its process of value/impact assessment of proposed regulatory actions. The principal conclusion is that approaches to rationally consider the value and impact of proposed regulatory actions are available. These approaches can potentially improve the decision-making process and enable the agency to better explain and defend its decisions. They also permit consistent examination of the impacts, effects of uncertainty and sensitivity to various assumptions of the alternatives being considered. Finally, these approaches can help to assure that affected parties are heard and that technical information is used appropriately and to the extent possible. The principal aspects of the regulatory decision problem covered in the report are: the legal setting for regulatory decisions which affect human health and safety, elements of the decision-making process, conceptual approaches to decision making, current approaches to decision making in several Federal agencies, and the determination of acceptable risk levels.

  15. A Review of Diabetes Mellitus and Exposure to the Environmental 
Toxicant Cadmium with an Emphasis on Likely Mechanisms of Action

    Edwards, Joshua; Ackerman, Christopher

    2016-01-01

    There is increasing interest in how exposure to environmental substances can contribute to the onset of Type II diabetes mellitus (T2DM). Impaired insulin release is a hallmark of type I diabetes mellitus and is involved in the progression of T2DM. Both epidemiological and experimental studies show that exposure to the environmental pollutant cadmium (Cd), is associated with hyperglycemia, T2DM and reduced serum insulin. The goal of this review is to examine likely mechanisms of action of Cd-induced dysglycemia based on experimental studies in the literature and from the most recent findings in the Edwards lab. The primary focus of this review will examine how Cd may cause islet dysfunction and subsequent impaired insulin release. Recent findings in the Edwards lab indicate that Cd causes time-dependent and statistically significant changes in fasting leptin, Glucose-dependent Insulinotropic Polypeptide (GIP) and pancreas polypeptide hormone levels in a subchronic animal model of Cd-induced hyperglycemia. This review summarizes the most likely cellular mechanisms by which the ubiquitous environmental contaminant Cd disrupts glucose homeostasis. While individual cellular effects of Cd are reviewed it is likely that no one single mechanism is involved, rather multiple mechanisms exist and work synergistically resulting in islet dysfunction and ultimately dysglycemia. PMID:26264451

  16. Integrated safety assessment report: Integrated Safety Assessment Program: Millstone Nuclear Power Station, Unit 1 (Docket No. 50-245): Draft report

    The Integrated Safety Assessment Program (ISAP) was initiated in November 1984, by the US Nuclear Regulatory Commission to conduct integrated assessments for operating nuclear power reactors. The integrated assessment is conducted in a plant-specific basis to evaluate all licensing actions, licensee initiated plant improvements and selected unresolved generic/safety issues to establish implementation schedules for each item. In addition, procedures will be established to allow for a periodic updating of the schedules to account for licensing issues that arise in the future. This report documents the review of Millstone Nuclear Power Station, Unit No. 1, operated by Northeast Nuclear Energy Company (located in Waterford, Connecticut). Millstone Nuclear Power Station, Unit No. 1, is one of two plants being reviewed under the pilot program for ISAP. This report indicates how 85 topics selected for review were addressed. This report presents the staff's recommendations regarding the corrective actions to resolve the 85 topics and other actions to enhance plant safety. The report is being issued in draft form to obtain comments from the licensee, nuclear safety experts, and the Advisory Committee for Reactor Safeguards (ACRS). Once those comments have been resolved, the staff will present its positions, along with a long-term implementation schedule from the licensee, in the final version of this report

  17. Geothermal Program Review XII: proceedings. Geothermal Energy and the President's Climate Change Action Plan

    1994-12-31

    Geothermal Program Review XII, sponsored by the Geothermal Division of US Department of Energy, was held April 25--28, 1994, in San Francisco, California. This annual conference is designed to promote effective technology transfer by bringing together DOE-sponsored researchers; utility representatives; geothermal energy developers; suppliers of geothermal goods and services; representatives from federal, state, and local agencies; and others with an interest in geothermal energy. In-depth reviews of the latest technological advancements and research results are presented during the conference with emphasis on those topics considered to have the greatest potential to impact the near-term commercial development of geothermal energy.

  18. Minutes from Department of Energy/Hazardous Waste Remedial Actions Program research and development technology needs assessment review meeting

    On November 1--2, 1988, representatives of the Department of Energy (DOE) Headquarters, DOE Operations Offices, DOE contractors, and the Hazardous Waste Remedial Actions Program met in Salt Lake City, Utah, to select and prioritize candidate waste problems in need of research and development. The information gained will be used in planning for future research and development tasks and in restructuring current research activities to address the priority needs. All Operations Offices were represented by DOE staff and by contractor delegates from the area. This document summarizes the results of the meeting and lists the priority waste problems established

  19. In Brief: Geoengineering draft statement

    Showstack, Randy

    2009-04-01

    The American Meteorological Society (AMS) has prepared a draft policy statement on geoengineering the climate system, which the AMS Council is considering for approval. The statement notes, “Geoengineering will not substitute for either aggressive mitigation or proactive adaptation. It could contribute to a comprehensive risk management strategy to slow climate change and alleviate its negative impacts, but the potential for adverse and unintended consequences implies a need for adequate research, appropriate regulation, and transparent consideration.” The statement, if adopted, indicates that AMS recommends enhanced research on the scientific and technological potential for geoengineering the climate system; additional study of the historical, ethical, legal, political, and societal aspects of the geoengineering issues; and the development and analysis of policy options to promote transparency and international cooperation in exploring geoengineering options along with restrictions on reckless efforts to manipulate the climate system. AMS is accepting comments on the draft statement until 23 April. For more information, visit http://ametsoc.org/policy/draftstatements/index.html#draft.

  20. Primary chemistry as an action lever to reduce the source term. Review of the experience at Doel 3 and 4

    Dose rate reduction is of primary concern in order to make nuclear energy part of the future energy mix. This article presents the chemistry related actions undertaken at Doel 3 and 4 units in order to reduce the source term. Doel 3 and 4 are two 3 loops 1000 MWe Pressurized Water Reactors which respectively started operating commercial in 1982 and 1985. Both units have undergone a steam generators replacement: from Inconel 600MA tubing material to Incoloy 800 in 1993 for D3 and to Inconel 690TT in 1996 for D4. Until now, very similar chemistry strategies during operation, startup and shutdown have been applied in both units. They are in good accordance with the international standards. Both units operate under a coordinated chemistry, with a target pHTave=7.2. Dissolved hydrogen concentration is maintained in the range 25-35 cc/kg STD H2O. During shutdown, oxygenation is performed at full loop by means of hydrogen peroxide injections. However, significant differences in dose rates have been observed between the two units, with higher levels in Doel 3. In an attempt to understand these differences and to define new improvements pathways to lower the dose rates, this article assesses the chemistry strategy based on the available radiochemistry data, the RCS oxide layers characterization and the measured dose rates around the primary system. Primary chemistry strategy seems to be suited to maintain low level of radiation fields at Doel 4. However, Doel 3 is characterized by a contamination mainly driven by the Co-60. Specific actions have to be undertaken to minimize dose rates at Doel 3. Regarding the high contribution of Co-60 to dose rates, zinc injection seems to be a promising mitigation technique. (author)

  1. There or not there? A multidisciplinary review and research agenda on the impact of transparent barriers on human perception, action, and social behavior.

    Marquardt, Gesine; Cross, Emily S; de Sousa, Alexandra A; Edelstein, Eve; Farnè, Alessandro; Leszczynski, Marcin; Patterson, Miles; Quadflieg, Susanne

    2015-01-01

    Through advances in production and treatment technologies, transparent glass has become an increasingly versatile material and a global hallmark of modern architecture. In the shape of invisible barriers, it defines spaces while simultaneously shaping their lighting, noise, and climate conditions. Despite these unique architectural qualities, little is known regarding the human experience with glass barriers. Is a material that has been described as being simultaneously there and not there from an architectural perspective, actually there and/or not there from perceptual, behavioral, and social points of view? In this article, we review systematic observations and experimental studies that explore the impact of transparent barriers on human cognition and action. In doing so, the importance of empirical and multidisciplinary approaches to inform the use of glass in contemporary architecture is highlighted and key questions for future inquiry are identified. PMID:26441756

  2. Negative-pressure wound therapy for management of diabetic foot wounds: a review of the mechanism of action, clinical applications, and recent developments

    Muhammed Y. Hasan

    2015-07-01

    Full Text Available Negative-pressure wound therapy (NPWT plays an important role in the treatment of complex wounds. Its effect on limb salvage in the management of the diabetic foot is well described in the literature. However, a successful outcome in this subgroup of diabetic patients requires a multidisciplinary approach with careful patient selection, appropriate surgical debridement, targeted antibiotic therapy, and optimization of healing markers. Evolving NPWT technology including instillation therapy, nanocrystalline adjuncts, and portable systems can further improve results if used with correct indications. This review article summarizes current knowledge about the role of NPWT in the management of the diabetic foot and its mode of action, clinical applications, and recent developments.

  3. Mathematical models of radiation action on living cells: From the target theory to the modern approaches. A historical and critical review.

    Bodgi, Larry; Canet, Aurélien; Pujo-Menjouet, Laurent; Lesne, Annick; Victor, Jean-Marc; Foray, Nicolas

    2016-04-01

    Cell survival is conventionally defined as the capability of irradiated cells to produce colonies. It is quantified by the clonogenic assays that consist in determining the number of colonies resulting from a known number of irradiated cells. Several mathematical models were proposed to describe the survival curves, notably from the target theory. The Linear-Quadratic (LQ) model, which is to date the most frequently used model in radiobiology and radiotherapy, dominates all the other models by its robustness and simplicity. Its usefulness is particularly important because the ratio of the values of the adjustable parameters, α and β, on which it is based, predicts the occurrence of post-irradiation tissue reactions. However, the biological interpretation of these parameters is still unknown. Throughout this review, we revisit and discuss historically, mathematically and biologically, the different models of the radiation action by providing clues for resolving the enigma of the LQ model. PMID:26807808

  4. Draft revision of human factors guideline HF-010

    Lee, Hyun Chul; Lee, Yong Hee; Oh, In Seok; Lee, Jung Woon [KAERI, Taejon (Korea, Republic of); Cha, Woo Chang [Kumoh National Institute of Technology, Gumi (Korea, Republic of); Lee, Dhong Ha [Suwon University, Suwon (Korea, Republic of)

    2003-05-01

    The Application of Human Factors to the design of Man-Machine Interfaces System(MMIS) in the nuclear power plant is essential to the safety and productivity of the nuclear power plants, human factors standards and guidelines as well as human factors analysis methods and experiments are weightily used to the design application. A Korean engineering company has developed a human factors engineering guideline, so-call HF-010, and has used it for human factors design, however the revision of HF-010 is necessary owing to lack of the contents related to the advanced MMI(Man-Machine Interfaces). As the results of the reviews of HF-010, it is found out that the revision of Section 9. Computer Displays of HF-010 is urgent, thus the revision was drafted on the basis of integrated human factors design guidelines for VDT, human factors design guidelines for PMAS SPADES display, human factors design guidelines for PMAS alarm display, and human factors design guidelines for electronic displays developed by the surveillance and operation support project of KOICS. The draft revision of HF-010 Section 9 proposed in this report can be utilized for the human factors design of the advanced MMI, and the high practical usability of the draft can be kept up through the continuous revision according to the advancement of digital technology.

  5. Draft revision of human factors guideline HF-010

    The Application of Human Factors to the design of Man-Machine Interfaces System(MMIS) in the nuclear power plant is essential to the safety and productivity of the nuclear power plants, human factors standards and guidelines as well as human factors analysis methods and experiments are weightily used to the design application. A Korean engineering company has developed a human factors engineering guideline, so-call HF-010, and has used it for human factors design, however the revision of HF-010 is necessary owing to lack of the contents related to the advanced MMI(Man-Machine Interfaces). As the results of the reviews of HF-010, it is found out that the revision of Section 9. Computer Displays of HF-010 is urgent, thus the revision was drafted on the basis of integrated human factors design guidelines for VDT, human factors design guidelines for PMAS SPADES display, human factors design guidelines for PMAS alarm display, and human factors design guidelines for electronic displays developed by the surveillance and operation support project of KOICS. The draft revision of HF-010 Section 9 proposed in this report can be utilized for the human factors design of the advanced MMI, and the high practical usability of the draft can be kept up through the continuous revision according to the advancement of digital technology

  6. The Anti-Inflammatory and Antibacterial Action of Nanocrystalline Silver and Manuka Honey on the Molecular Alternation of Diabetic Foot Ulcer: A Comprehensive Literature Review

    Tsang, Ka-Kit; Kwong, Enid Wai-Yung; Woo, Kevin Y.; To, Tony Shing-Shun; Chung, Joanne Wai-Yee; Wong, Thomas Kwok-Shing

    2015-01-01

    Honey and silver have been used since ancient times for treating wounds. Their widespread clinical application has attracted attention in light of the increasing prevalence of antibiotic-resistant bacteria. While there have been a number of studies exploring the anti-inflammatory and antibacterial effects of manuka honey and nanocrystalline silver, their advantages and limitations with regard to the treatment of chronic wounds remain a subject of debate. The aim of this paper is to examine the evidence on the use of nanocrystalline silver and manuka honey for treating diabetic foot ulcers through a critical and comprehensive review of in vitro studies, animal studies, and in vivo studies. The findings from the in vitro and animal studies suggest that both agents have effective antibacterial actions. Their anti-inflammatory action and related impact on wound healing are unclear. Besides, there is no evidence to suggest that any topical agent is more effective for use in treating diabetic foot ulcer. Overall, high-quality, clinical human studies supported by findings from the molecular science on the use of manuka honey or nanocrystalline silver are lacking. There is a need for rigorously designed human clinical studies on the subject to fill this knowledge gap and guide clinical practice. PMID:26290672

  7. 1 CFR 21.1 - Drafting.

    2010-01-01

    ... 1 General Provisions 1 2010-01-01 2010-01-01 false Drafting. 21.1 Section 21.1 General Provisions ADMINISTRATIVE COMMITTEE OF THE FEDERAL REGISTER PREPARATION, TRANSMITTAL, AND PROCESSING OF DOCUMENTS PREPARATION OF DOCUMENTS SUBJECT TO CODIFICATION General § 21.1 Drafting. (a) Each agency that prepares...

  8. Teaching Drafting 101: What Comes First?

    Carkhuff, Don

    2006-01-01

    Employers require pristine drawings that convey clarity and precision for the production of goods. Can a change in sequence of instruction be expeditious and help teachers better prepare their students for the workplace? Research suggests that combining traditional drafting and computer-aided drafting (CAD) instruction makes sense. It is analogous…

  9. Automated drafting system uses computer techniques

    Millenson, D. H.

    1966-01-01

    Automated drafting system produces schematic and block diagrams from the design engineers freehand sketches. This system codes conventional drafting symbols and their coordinate locations on standard size drawings for entry on tapes that are used to drive a high speed photocomposition machine.

  10. 27 CFR 20.101 - Drafting formulas.

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Drafting formulas. 20.101 Section 20.101 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Process Approval Policies § 20.101 Drafting formulas. (a) In preparing Form 5150.19, the...

  11. On the Drafting of Confidentiality Agreements

    Drewsen, Merete; Lando, Henrik; Cummins, Tim

    2006-01-01

    This is not a theoretical paper but an application of existing law and economic contract theory to the issue of how to draft a specific kind of contract. It is addressed to practitioners and is intended for practical use. It will be part of a Wiki (as in Wikipedia) for contract drafting, which...

  12. Complementary and alternative medicine in the treatment of refugees and survivors of torture: a review and proposal for action.

    Longacre, McKenna; Silver-Highfield, Ellen; Lama, Puja; Grodin, Michael

    2012-01-01

    Survivors of torture and refugee trauma often have increased needs for mental and physical healthcare. This is due in part to the complex sequelae of trauma, including chronic pain, major depressive disorder, posttraumatic stress disorder (PTSD) and somatization. This article reviews the scientific medical literature for the efficacy and feasibility of some complementary and alternative medicine (CAM) modalities including meditation, Ayurveda, pranayama/yogic breathing, massage/body-work, dance/movement, spirituality, yoga, music, Traditional Chinese Medicine and acupuncture, qigong, t'ai chi, chiropractic, homeopathy, aromatherapy and Reiki specifically with respect to survivors of torture and refugee trauma. We report that preliminary research suggests that the certain CAM modalities may prove effective as part of an integrated treatment plan for survivors of torture and refugee trauma. Further research is warranted. PMID:23086004

  13. Constructing racial hierarchies of skill – Experiencing affirmative action in a South African organisation: A qualitative review

    Shanya Reuben

    2014-05-01

    Full Text Available Orientation: Apartheid in South Africa constructed racial, economic, social and political segregation, the consequences of which are still experienced today. Government has made concerted efforts to ‘deracialise’ South Africa, most notably through affirmative action (AA measures. Research purpose: This study aimed to explore employees’ social constructions of AA in a South African organisation. Motivation for the study: Research in this field focuses mostly on attitudinal perspectives of AA with an emphasis on traditional approaches. Subjective, contextualised approaches to AA have received little attention. Thus, this study aimed to critically engage with the embodied nature of prejudice, particularly in reference to how we understand and experience AA. Research approach, design and method: This study aimed to explore AA from a social constructionist orientation, using semi-structured interviews. More specifically, this study used Potter and Wetherell’s discursive psychology. Main findings: The findings illustrate how participants engage in discursive devices that continue to rationalise a racial order of competence. Ultimately, AA is a controversial subject that traverses many segments of life for all South Africans. Practical/managerial implications: The findings contribute to the discipline of industrial psychology, particularly with regard to policies around preferential treatment, and can add value to the ways in which organisational policy documents are conceptualised. The findings also suggest the importance of developing an inclusive, non-discriminatory organisational culture. Contribution/value-add: This approach adds to the existing body of knowledge around the embodied nature of prejudice. The study’s methodology highlights the value of studying context in meaning-making and implied inferences that underlie talk.

  14. Constructing racial hierarchies of skill – Experiencing affirmative action in a South African organisation: A qualitative review

    Shanya Reuben

    2014-02-01

    Full Text Available Orientation: Apartheid in South Africa constructed racial, economic, social and political segregation, the consequences of which are still experienced today. Government has made concerted efforts to ‘deracialise’ South Africa, most notably through affirmative action (AA measures.Research purpose: This study aimed to explore employees’ social constructions of AA in a South African organisation.Motivation for the study: Research in this field focuses mostly on attitudinal perspectives of AA with an emphasis on traditional approaches. Subjective, contextualised approaches to AA have received little attention. Thus, this study aimed to critically engage with the embodied nature of prejudice, particularly in reference to how we understand and experience AA.Research approach, design and method: This study aimed to explore AA from a social constructionist orientation, using semi-structured interviews. More specifically, this study used Potter and Wetherell’s discursive psychology.Main findings: The findings illustrate how participants engage in discursive devices that continue to rationalise a racial order of competence. Ultimately, AA is a controversial subject that traverses many segments of life for all South Africans.Practical/managerial implications: The findings contribute to the discipline of industrial psychology, particularly with regard to policies around preferential treatment, and can add value to the ways in which organisational policy documents are conceptualised. The findings also suggest the importance of developing an inclusive, non-discriminatory organisational culture.Contribution/value-add: This approach adds to the existing body of knowledge around the embodied nature of prejudice. The study’s methodology highlights the value of studying context in meaning-making and implied inferences that underlie talk.

  15. Draft Mission Plan Amendment

    The Department of Energy's Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation's spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs

  16. Draft Mission Plan Amendment

    NONE

    1991-09-01

    The Department of Energy`s Office Civilian Radioactive Waste Management has prepared this document to report plans for the Civilian Radioactive Waste Management Program, whose mission is to manage and dispose of the nation`s spent fuel and high-level radioactive waste in a manner that protects the health and safety of the public and of workers and the quality of the environment. The Congress established this program through the Nuclear Waste Policy Act of 1982. Specifically, the Congress directed us to isolate these wastes in geologic repositories constructed in suitable rock formations deep beneath the surface of the earth. In the Nuclear Waste Policy Amendments Act of 1987, the Congress mandated that only one repository was to be developed at present and that only the Yucca Mountain candidate site in Nevada was to be characterized at this time. The Amendments Act also authorized the construction of a facility for monitored retrievable storage (MRS) and established the Office of the Nuclear Waste Negotiator and the Nuclear Waste Technical Review Board. After a reassessment in 1989, the Secretary of Energy restructured the program, focusing the repository effort scientific evaluations of the Yucca Mountain candidate site, deciding to proceed with the development of an MRS facility, and strengthening the management of the program. 48 refs., 32 figs.

  17. A Review of Human Action Recognition Based on Deep Learning%基于深度学习的人体行为识别算法综述

    朱煜; 赵江坤; 王逸宁; 郑兵兵

    2016-01-01

    人体行为识别和深度学习理论是智能视频分析领域的研究热点,近年来得到了学术界及工程界的广泛重视,是智能视频分析与理解、视频监控、人机交互等诸多领域的理论基础。近年来,被广泛关注的深度学习算法已经被成功运用于语音识别、图形识别等各个领域。深度学习理论在静态图像特征提取上取得了卓著成就,并逐步推广至具有时间序列的视频行为识别研究中。本文在回顾了基于时空兴趣点等传统行为识别方法的基础上,对近年来提出的基于不同深度学习框架的人体行为识别新进展进行了逐一介绍和总结分析;包括卷积神经网络(Convolution neural network, CNN)、独立子空间分析(Independent subspace analysis, ISA)、限制玻尔兹曼机(Restricted Boltzmann machine, RBM)以及递归神经网络(Recurrent neural network, RNN)及其在行为识别中的模型建立,对模型性能、成果进展及各类方法的优缺点进行了分析和总结。%Human action recognition is an active research topic in intelligent video analysis and is gaining extensive attention in academic and engineering communities. This technology is an important basis of intelligent video analysis, video tagging, human computer interaction and many other fields. The deep learning theory has been made remarkable achievements on still image feature extraction and gradually extends to the time sequences of human action videos. This paper reviews the traditional design of action recognition methods, such as spatial-temporal interest point, introduces and analyzes different human action recognition framework based on deep learning, including convolution neural network (CNN), independent subspace analysis (ISA) model, restricted Boltzmann machine (RBM), and recurrent neural network (RNN). Finally, this paper summarizes the advantages and disadvantages of these methods.

  18. 77 FR 61624 - Patuxent Research Refuge, Prince George's and Anne Arundel Counties, MD; Draft Comprehensive...

    2012-10-10

    ... measures to control invasive species, monitor and abate diseases affecting wildlife and plant health... Federal Register (75 FR 12563; March 16, 2010). Patuxent RR was established in 1936 by Executive Order by... Anne Arundel Counties, Maryland, for public review and comment. The draft CCP/EA describes our...

  19. 78 FR 1879 - Endangered and Threatened Wildlife and Plants; Draft Revised Indiana Bat Summer Survey Guidelines

    2013-01-09

    ... Endangered and Threatened Wildlife and Plants; Draft Revised Indiana Bat Summer Survey Guidelines AGENCY... survey guidelines for the Indiana bat (Myotis sodalis) for public review and comment. The Indiana bat is...: Field Supervisor at the above U.S. mail address; Email: indiana_bat@fws.gov ; or Fax:...

  20. Compilation of Physicochemical and Toxicological Information About Hydraulic Fracturing-Related Chemicals (Draft Database)

    The purpose of this product is to make accessible the information about the 1,173 hydraulic fracturing-related chemicals that were listed in the external review draft of the Hydraulic Fracturing Drinking Water Assessment that was released recently. The product consists of a serie...

  1. Draft Plan for Development of the Integrated Science Assessment for Nitrogen Oxides - Health Criteria

    EPA has announced a draft development plan for the next Integrated Science Assessment (ISA) for the health effects of nitrogen oxides (NOX) which will serve as the scientific basis for review of the primary (health-based) National Ambient Air Quality Standard for nitrogen dioxide...

  2. 77 FR 11140 - Availability of the Draft Supplementary Risk Assessment for the Boston University (BU) National...

    2012-02-24

    ...-emerging infectious diseases. The NIH completed and published a final Environmental Impact Statement (EIS... Environmental Policy Act. Construction of the NEIDL began at the BioSquare II Research Park on Albany Street... separate environmental review prepared pursuant to a Massachusetts law. The Draft Supplementary...

  3. 78 FR 54476 - Availability of Draft National Toxicology Program Technical Reports; Request for Comments; Notice...

    2013-09-04

    ... available by September 20, 2013, at http://ntp.niehs.nih.gov/go/36051 . The peer-review meeting is open to... the meeting and registration are available at http://ntp.niehs.nih.gov/go/36051 . DATES: Meeting...: Draft TRs should be available by September 20, 2013, at http://ntp.niehs.nih.gov/go/36051 ....

  4. 77 FR 45597 - Middle Fork American River Project; Notice of Availability of the Draft Environmental Impact...

    2012-08-01

    ... Energy Regulatory Commission Middle Fork American River Project; Notice of Availability of the Draft Environmental Impact Statement for the Middle Fork American River Hydrolectric Project and Intention To Hold... CFR part 380 ), the Office of Energy Projects has reviewed the application for license for the...

  5. Draft area recommendation report for the Crystalline Repository Project: Comments: Final technical report

    The Mille Lacs Band conducted a review of the draft area recommendation report (ARR) and provided comments as outlined in the contract. It also had staff attending the necessary training and informational meeting established by the Department of Energy. This had met all the necessary objectives as outlined in the contract

  6. Yakima Fisheries Project : Revised Draft Environmental Impact Statement.

    United States. Bonneville Power Administration.

    1995-05-01

    BPA proposes to fund several fishery-related activities in the Yakima River Basin. The Yakima Fisheries Project (YFP), included in the Northwest Power Planning Council`s fish and wildlife program, would be jointly managed by the State of Washington and the Yakima Indian Nation. Fisheries resources in the Yakima River are severely reduced from historical levels and there is a significant potential for enhancement of these resources. BPA`s proposed action is to fund (1) information gathering on the implementation of supplementation techniques and on feasibility of reintroducing coho salmon in an environment where native populations have become extinct; (2) research activities based on continuous assessment, feedback and improvement of research design and activities ({open_quotes}adaptive management{close_quotes}); and (3) the construction, operation, and maintenance of facilities for supplementing populations of upper Yakima spring chinook salmon. The project has been considerably revised from the original proposal described in the first draft EIS. Examined in addition to No Action (which would leave present anadromous fisheries resources unchanged in the, Basin) are two alternatives for action: (1) supplementation of depressed natural populations of upper Yakima spring chinook and (2) that same supplementation plus a study to determine the feasibility of re-establishing (via stock imported from another basin) naturally spawning population and a significant fall fishery for coho in the Yakima Basin. Alternative 2 has been identified as the preferred action. Major issues examined in the Revised Draft EIS include potential impacts of the project on genetic and ecological resources of existing fish populations, on water quality and quantity, on threatened and endangered species listed under the Endangered Species Act, and on the recreational fishery.

  7. Business Plan in Brief : Draft.

    United States. Bonneville Power Administration.

    1994-06-01

    Competition is revolutionizing the electricity industry, and utilities may never be the same. In the past two decades, government deregulation has transformed the airline, cable television, natural gas, and telecommunications industries. Now, with the passage of new laws which have spurred the growth of independent power and opened up transmission access, the electric utility industry has become the laboratory for change. Here in the Northwest, dramatic changes in the electric industry mean that the Bonneville Power Administration (BPA) is facing real competition. Our customers have more choices than they had in the past. BPA`s draft Business Plan is a direct response to this changing environment. The plan presents how we propose to adapt to the new competitive marketplace. This is a summary of the plan and some of the important issues it raises for regional discussion. The draft plan contains much more detail on all the topics mentioned here. Business Plan is BPA`s first attempt to integrate the long-term strategic plans of the various parts of the agency with a strategic financial plan. Change is evident throughout the plan--change in our operating environment, in our strategic direction, in our customer and constituent relationships, and in BPA itself as an organization.

  8. Business plan in brief. Draft

    Competition is revolutionizing the electricity industry, and utilities may never be the same. In the past two decades, government deregulation has transformed the airline, cable television, natural gas, and telecommunications industries. Now, with the passage of new laws which have spurred the growth of independent power and opened up transmission access, the electric utility industry has become the laboratory for change. Here in the Northwest, dramatic changes in the electric industry mean that the Bonneville Power Administration (BPA) is facing real competition. Our customers have more choices than they had in the past. BPA's draft Business Plan is a direct response to this changing environment. The plan presents how we propose to adapt to the new competitive marketplace. This is a summary of the plan and some of the important issues it raises for regional discussion. The draft plan contains much more detail on all the topics mentioned here. Business Plan is BPA's first attempt to integrate the long-term strategic plans of the various parts of the agency with a strategic financial plan. Change is evident throughout the plan--change in our operating environment, in our strategic direction, in our customer and constituent relationships, and in BPA itself as an organization

  9. Intentional Action and Action Slips.

    Heckhausen, Heinz; Beckmann, Jurgen

    1990-01-01

    An explanation of action slips is offered that examines controlled actions in the context of an intentional behavior theory. Actions are considered guided by mentally represented intentions, subdivided into goal intentions and contingent instrumental intentions. Action slips are categorized according to problem areas in the enactment of goal…

  10. Gulf of Mexico sales 147 and 150: Central and western planning areas. Draft environmental impact statement. Volume 1. Sections I through IV.C. Draft report

    The Draft Environmental Impact Statement (EIS) covers the proposed 1994 Gulf of Mexico OCS oil and gas lease sales (Central Gulf of Mexico Sale 147 (March 1994) and Western Gulf of Mexico Sale 150 (August 1994)). The document includes the purpose and background of the proposed actions, the alternatives, the description of the affected environment, and the potential environmental impacts of the proposed actions and alternatives. Proposed mitigating measures and their effects are analyzed, in addition to potential cumulative impacts resulting from proposed activities

  11. Draft Law on radiation protection in the Republic of Montenegro. Highlights and problems

    After major constitutional changes in 2003, which redefined Serbia and Montenegro as (de facto) a loose confederation of the two constituent states, all nuclear related issues went separately to the portfolios of the Republic of Serbia and of the Republic of Montenegro. Within the establishing of nuclear regulatory framework(s), and towards meeting the international requirements, draft Law on radiation protection in the Republic of Montenegro (including safety/security of sources) is prepared according to international (IAEA, EU, ...) standards. The draft is positively reviewed by IAEA expert missions. However, it turned out that the draft (in particular some of its provisions enabling the effective independence of the regulatory body) is conflicting with fundamental Montenegrian laws on the organization of State. A sound legal/institutional infrastructure for radiation protection, and safety/security of radiation sources in Montenegro cannot be established until this situation changes. (author)

  12. 75 FR 76467 - Draft Concept for Government-Wide “ExpertNet” Platform and Process To Elicit Expert Public...

    2010-12-08

    ... From the Federal Register Online via the Government Publishing Office GENERAL SERVICES ADMINISTRATION Draft Concept for Government-Wide ``ExpertNet'' Platform and Process To Elicit Expert Public Participation in Response to Government Questions AGENCY: U.S. General Services Administration. ACTION:...

  13. 78 FR 74154 - Draft Guidance for Industry on Size, Shape, and Other Physical Attributes of Generic Tablets and...

    2013-12-10

    ... Physical Attributes of Generic Tablets and Capsules; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a draft guidance for industry entitled ``Size, Shape, and Other Physical Attributes of Generic Tablets and...

  14. 76 FR 70768 - Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft...

    2011-11-15

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Common-Cause Failure Analysis in Event and Condition Assessment: Guidance and Research, Draft... November 2, 2011 (76 FR 67764). This action is necessary to correct an erroneous date for submission...

  15. 75 FR 60805 - Notice of Availability of a Draft Environmental Impact Statement for the Gasco Uinta Basin...

    2010-10-01

    ... Proposed Action and alternatives incorporate best management practices for oil and gas development and..., we cannot guarantee that we will be able to do so. Juan Palma, State Director. BILLING CODE 4310-DQ-P ... Bureau of Land Management Notice of Availability of a Draft Environmental Impact Statement for the...

  16. 78 FR 19212 - Notice of Availability of a Supplemental Draft Environmental Impact Statement for Effects of Oil...

    2013-03-29

    ... for the take of marine mammals incidental to oil and gas industry exploration activities in the U.S... Register (76 FR 82275). The 2011 DEIS includes an analysis of the proposed actions identified in the 2010... Draft Environmental Impact Statement for Effects of Oil and Gas Activities in the Arctic Ocean...

  17. 78 FR 6303 - Notice of Intent To Prepare a Supplemental Draft Environmental Impact Statement on the Effects of...

    2013-01-30

    ... Mammal Protection Act (MMPA) Incidental Take Authorizations (ITAs) to the oil and gas industry for the... to oil and gas industry exploration activities in the U.S. Arctic Ocean and BOEM's proposed action of... EIS in the Federal Register (76 FR 82275). The Draft EIS includes an analysis of the proposed...

  18. Draft Environmental Statement related to the operation of Beaver Valley Power Station, Unit 2 (Docket No. 50-412)

    This Draft Environmental Statement contains the second assessment of the environmental impact associated with Beaver Valley Power Station Unit 2 pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental benefits and costs

  19. 76 FR 77542 - Draft Guidance for Industry and Food and Drug Administration Staff on Humanitarian Use Device...

    2011-12-13

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry and Food and Drug Administration Staff on Humanitarian Use Device Designations; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is announcing the availability of a...

  20. 78 FR 39736 - Draft Guidance for Industry: Considerations for the Design of Early-Phase Clinical Trials of...

    2013-07-02

    ... HUMAN SERVICES Food and Drug Administration Draft Guidance for Industry: Considerations for the Design of Early-Phase Clinical Trials of Cellular and Gene Therapy Products; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug Administration (FDA) is...

  1. On Research in Action and Action in Research

    Blichfeldt, Bodil Stilling; Andersen, Jesper Rank

    2005-01-01

    A unique (and challenging) characteristic of social sciences is that these sci-ences are multi-paradigmatic and adhere to a wide range of research strategies. One research strategy that social scientists can choose to rely on is action re-search. However, action research qualifies as a research strategy much criticised for not being subject to scientific rigor. Drawing on an extensive review of the literature on action research, this paper discusses what action research is (not) and what it c...

  2. Theory of reasoned action and theory of planned behavior-based dietary interventions in adolescents and young adults: a systematic review

    Hackman CL

    2014-06-01

    Full Text Available Christine L Hackman, Adam P KnowldenDepartment of Health Science, The University of Alabama, Tuscaloosa, AL, USABackground: Childhood obesity has reached epidemic proportions in many nations around the world. The theory of planned behavior (TPB and the theory of reasoned action (TRA have been used to successfully plan and evaluate numerous interventions for many different behaviors. The aim of this study was to systematically review and synthesize TPB and TRA-based dietary behavior interventions targeting adolescents and young adults.Methods: The following databases were systematically searched to find articles for this review: Academic Search Premier; Cumulative Index to Nursing and Allied Health (CINAHL; Education Resources Information Center (ERIC; Health Source: Nursing/Academic Edition; Cochrane Central Register of Controlled Trials (CENTRAL; and MEDLINE. Inclusion criteria for articles were: 1 primary or secondary interventions, 2 with any quantitative design, 3 published in the English language, 4 between January 2003 and March 2014, 5 that targeted adolescents or young adults, 6 which included dietary change behavior as the outcome, and 7 utilized TPB or TRA.Results: Of the eleven intervention studies evaluated, nine resulted in dietary behavior change that was attributed to the treatment. Additionally, all but one study found there to be a change in at least one construct of TRA or TPB, while one study did not measure constructs. All of the studies utilized some type of quantitative design, with two employing quasi-experimental, and eight employing randomized control trial design. Among the studies, four utilized technology including emails, social media posts, information on school websites, web-based activities, audio messages in classrooms, interactive DVDs, and health-related websites. Two studies incorporated goal setting and four employed persuasive communication.Conclusion: Interventions directed toward changing dietary behaviors

  3. Reviews

    2002-05-01

    BOOK REVIEWS (269) The Science of Imaging - An Introduction Northern Lights Vacuum Bazookas, Electric Rainbow Jelly, and 27 other Saturday Science Projects Physics and Engineering in Medicine in the New Millennium CD-ROM REVIEWS (272) I fell in love with a STARBase trooper Aber - greatest hits... WEB WATCH (273) 'Here is the guess of their true strength and forces' Gary Williams EDITOR'S NOTE (275) Reviews of Christopher Bishop's Astrophysics (John Murray, 2000) PHYSICS TEASER (276) Why or How, Sophistry and Guestimation

  4. Draft environmental statement related to the operation of River Bend Station (Docket No. 50-458)

    This draft environmental statement contains the second assessment of the environmental impact associated with the operation of River Bend Station, pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs

  5. Draft Environmental Impact Statement: Lostwood Proposed Wilderness

    US Fish and Wildlife Service, Department of the Interior — This document is a draft of an analysis of the environmental impact wilderness designation would pose for the proposed Lostwood Wilderness area. Topics covered...

  6. Draft environmental statement : Proposed Valentine Wilderness area

    US Fish and Wildlife Service, Department of the Interior — This document is a draft of an analysis of the environmental impact wilderness designation would pose for the Valentine National Wildlife Refuge. Topics covered...

  7. Regulatory requirements for ISI qualification. Draft

    The report present drafts for the regulation documents worked out by the Committee of the Use of Atomic Energy for Peaceful Purposes. It contains the Regulatory requirements for ISI qualifications and Regulatory requirements for the Qualification Body

  8. Alaska gold rush trails study: Preliminary draft

    US Fish and Wildlife Service, Department of the Interior — Preliminary study draft, with maps, of seven gold rush trails in Alaska, to determine suitability for inclusion in the National Scenic Trails system and their...

  9. The draft Mission Plan Amendment

    The draft Mission Plan Amendment provides an opportunity for States and Indian Tribes and other involved parties to participate in a process that no other nation affords its citizens. More than just a comment period on a Department of Energy document, the amendment that is to be submitted later this year will lay before Congress, the documentary basis on which to make decisions about the scope and timing of the high-level waste program in what Secretary Herrington has called a ''crossroads'' years. The Amendment will distill the view of the participants and also preset them to Congress as an integral part of the document. After four years of effort, the Nation is being afforded an opportunity to ask itself again whether the Act passed in 1982 is working and remains the best way to protect the public interest

  10. A Review of Supplementary Medical Aspects of Post-Cold War UN Peacekeeping Operations: Trends, Lessons Learned, Courses of Action, and Recommendations.

    Johnson, Ralph J

    2015-01-01

    Post-Cold War United Nations Peace Keeping Operations (UN PKOs) have been increasingly involved in dangerous areas with ill-defined boundaries, harsh and remote geographies, simmering internecine armed conflict, and disregard on the part of some local parties for peacekeepers' security and role. In the interest of force protection and optimizing operations, a key component of UN PKOs is healthcare and medical treatment. The expectation is that UN PKO medical support will adjust to the general intent and structure of UN PKOs. To do so requires effective policies and planning informed by a review of all medical aspects of UN PKO operations, including those considered supplementary, that is, less crucial but contributing nonetheless. Medical aspects considered paramount and key to UN PKOs have received relatively thorough treatment elsewhere. The intent of this article is to report on ancillary and supplemental medical aspects practical to post-Cold War UN PKO operations assembled through an iterative inquiry of open-source articles. Recommendations are made about possible courses of action in terms of addressing trends found in such medical aspects of PKOs and relevance of US/NATO/European Union models and research. PMID:26606413

  11. GRETA’s First Years of Work: Review of the monitoring of implementation of the Council of Europe Convention on Action against Trafficking in Human Beings

    Julia Planitzer

    2012-09-01

    Full Text Available The monitoring mechanism of the Council of Europe Convention on Action against Trafficking in Human Beings (CoE Convention consists of an independent group of experts (GRETA and a Committee of Parties. GRETA, which began work in 2009, develops questionnaires for States Parties, reviews their replies and conducts study visits. It then produces a report that is used by the Committee of Parties to make recommendations. This article analyses GRETA’s work until November 2011 by assessing the available materials including the questionnaire, the three published replies of States Parties to the questionnaire and the five published final reports on the parties. The objective of the article is to examine the capacity of this process to contribute to enhancing the accountability of States Parties, and to consider whether the application of a human rights-based approach by the parties can, in fact, be effectively monitored. The article also considers the role of civil society in the monitoring process and the ways in which this could be enhanced.

  12. On the Drafting of Confidentiality Agreements

    Drewsen, Merete; Lando, Henrik; Cummins, Tim

    2006-01-01

    This is not a theoretical paper but an application of existing law and economic contract theory to the issue of how to draft a specific kind of contract. It is addressed to practitioners and is intended for practical use. It will be part of a Wiki (as in Wikipedia) for contract drafting, which IACCM (International Association for Contract and Commercial Management) has initiated. The main theoretical aspect of the article concerns the application of the value maximization principle (the Coase...

  13. The hydrodynamics of dolphin drafting

    Weihs Daniel

    2004-05-01

    Full Text Available Abstract Background Drafting in cetaceans is defined as the transfer of forces between individuals without actual physical contact between them. This behavior has long been surmised to explain how young dolphin calves keep up with their rapidly moving mothers. It has recently been observed that a significant number of calves become permanently separated from their mothers during chases by tuna vessels. A study of the hydrodynamics of drafting, initiated in the hope of understanding the mechanisms causing the separation of mothers and calves during fishing-related activities, is reported here. Results Quantitative results are shown for the forces and moments around a pair of unequally sized dolphin-like slender bodies. These include two major effects. First, the so-called Bernoulli suction, which stems from the fact that the local pressure drops in areas of high speed, results in an attractive force between mother and calf. Second is the displacement effect, in which the motion of the mother causes the water in front to move forwards and radially outwards, and water behind the body to move forwards to replace the animal's mass. Thus, the calf can gain a 'free ride' in the forward-moving areas. Utilizing these effects, the neonate can gain up to 90% of the thrust needed to move alongside the mother at speeds of up to 2.4 m/sec. A comparison with observations of eastern spinner dolphins (Stenella longirostris is presented, showing savings of up to 60% in the thrust that calves require if they are to keep up with their mothers. Conclusions A theoretical analysis, backed by observations of free-swimming dolphin schools, indicates that hydrodynamic interactions with mothers play an important role in enabling dolphin calves to keep up with rapidly moving adult school members.

  14. Mississippi Curriculum Framework for Drafting and Design Technology (Program CIP: 48.0102--Architectural Drafting Technology) (Program CIP: 48.0101--General Drafting). Postsecondary Programs.

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which is intended for use by community and junior colleges throughout Mississippi, contains curriculum frameworks for the two course sequences of the state's postsecondary-level drafting and design technology program: architectural drafting technology and drafting and design technology. Presented first are a program description and…

  15. Book review: Agroecology in action

    Agroecology extends the boundaries of modern agriculture relying primarily on reductionistic scientific investigations of how plants and animals respond to and interact with the environment to a more holistic understanding between humans and nature to produce more sustainable agricultural systems th...

  16. GCIG Consensus Review: Uterine and Ovarian Leiomyosarcomas

    Hensley, Martee L.; Barrette, Brigitte A.; Baumann, Klaus; Gaffney, David; Hamilton, Anne L.; Kim, Jae-Weon; Maenpaa, Johanna U.; Pautier, Patricia; Siddiqui, Nadeem Ahmad; Westermann, Anneke M.; Ray-Coquard, Isabelle

    2016-01-01

    Objective The GCIG aimed to provide an overview of uterine and ovarian leiomyosarcoma management. Methods Published articles and author experience were used to draft management overview. The draft manuscript was circulated to international members of the GCIG for review and comment, and appropriate revisions were made. Results The approach to management of uterine and ovarian leiomyosarcoma management is reviewed. Conclusions Uterine and ovarian leiomyosarcomas are rare, aggressive cancers that require specialized expertise for optimal management. PMID:25341583

  17. 77 FR 55222 - Notice of Availability of the Draft Resource Management Plan Amendment and the Draft...

    2012-09-07

    ... Draft Environmental Impact Statement for Oil and Gas Development for the White River Field Office in..., and/or mailings. ADDRESSES: You may submit comments related to the WRFO Oil and Gas Development Draft...-878-3805. Mail: BLM--WRFO, 220 East Market Street, Meeker, Colorado 81641. Copies of the WRFO Oil...

  18. 77 FR 3777 - Draft and Revised Draft Guidances for Industry Describing Product-Specific Bioequivalence...

    2012-01-25

    ... (ANDAs). In the Federal Register of May 31, 2007 (72 FR 30386), FDA announced the availability of a draft... FR 62793). This notice announces draft product- specific recommendations, either new or revised, that... Product-Specific Bioequivalence Recommendations; Availability AGENCY: Food and Drug Administration,...

  19. 77 FR 42756 - Draft Environmental Impact Statement and Draft Habitat Conservation Plan for Incidental Take of...

    2012-07-20

    ... Texas troglobitic water slater (Lirceolus smithii) in case they are listed during the duration of the..., and the Edwards Aquifer Authority; San Antonio Water Systems; City of New Braunfels, Texas; City of... Fish and Wildlife Service Draft Environmental Impact Statement and Draft Habitat Conservation Plan...

  20. 76 FR 55941 - Notice of Availability of the Draft Bakersfield Resource Management Plan and Draft Environmental...

    2011-09-09

    ... proposed ACEC are special status plant species and rare plant community. Proposed limitations address land... Bureau of Land Management Notice of Availability of the Draft Bakersfield Resource Management Plan and Draft Environmental Impact Statement, California AGENCY: Bureau of Land Management, Interior....

  1. Mississippi Curriculum Framework for General Drafting (Program CIP: 48.0101--Drafting, General). Secondary Programs.

    Mississippi Research and Curriculum Unit for Vocational and Technical Education, State College.

    This document, which reflects Mississippi's statutory requirement that instructional programs be based on core curricula and performance-based assessment, contains outlines of the instructional units required in local instructional management plans and daily lesson plans for two secondary-level courses in drafting: drafting I and II. Presented…

  2. Draft national health policy 2015: A critical appraisal.

    Ahmed, Faruque U

    2016-01-01

    Revising a health policy of any country is a periodic procedure dependent on the change of demographic profile, current health status of the population including epidemiological changes in disease prevalence pattern, and progress made under the earlier policies. Along with it, newer research revelation of the natural history of the existing and emerging health problems, availability of newer technology as well as changing sociopolitical commitment to improve the health status of the population are the driving forces in the change of policy. Draft National Health Policy (NHP) 2015 is an attempt for the same. A review of the draft has been undertaken. The chapter on introduction is crisp and clear. Situation analysis of the draft is sketchy and without any reference of sources. Shifting the health goal is without any basis, and the objectives defined for the policy change are incongruous with the introduction. A detailed description does not give a clear picture but rather confuses the reader as it talks of comprehensive universal health-care services to be provided with a holistic concept but maximum emphasis is made in the implementation of a national program. Private health-care services are an area to reckon but except for mere references on the involvement in private-public mode, nothing concrete is observed, especially in the primary care level. Involvement envisaged in the secondary and tertiary levels is nebulous. The implementation health insurance program as well as regulatory mechanISM with the existing is also not defined exclusively in the context of a newer health policy. PMID:26911216

  3. Standard review plan for the review and evaluation of emergency plans for research and test reactors. Technical report

    This document provides a Standard Review Plan for the guidance of the NRC staff to assure that complete and uniform reviews are made of research and test reactor emergency plans. The report is organized under ten planning standards which correspond to the guidance criteria in Draft II of ANSI/ANS 15.16 as endorsed by Revision 1 to Regulatory Guide 2.6. The applicability of the items under each planning standard is indicated by subdivisions of the steady state thermal power levels at which the reactors are licensed to operate. Standard emergency classes and example action levels for research and test reactors which should initiate these classes are given in an Appendix

  4. Health impact assessment as an agent of policy change: improving the health impacts of the mayor of London's draft transport strategy

    Mindell, J; Sheridan, L.; Joffe, M.; Samson-Barry, H.; Atkinson, S.

    2004-01-01

    Objective: To increase the positive and mitigate the negative health impacts of the mayor's draft transport strategy for London.Design: A rapid prospective health impact assessment (HIA) of the penultimate draft of the strategy, using a review commissioned by the regional director of public health; an appraisal of congestion charging; and a participatory workshop. Two audits of changes were performed to assess the impact on policy of the HIA process.Setting: Regional government policy develop...

  5. Stem cell therapy to protect and repair the developing brain: a review of mechanisms of action of cord blood and amnion epithelial derived cells

    Margie eCastillo-Melendez

    2013-10-01

    Full Text Available In the research, clinical and wider community there is great interest in the use of stem cells to reduce the progression, or indeed repair brain injury. Perinatal brain injury may result from acute or chronic insults sustained during fetal development, during the process of birth, or in the newborn period. The most readily identifiable outcome of perinatal brain injury is cerebral palsy, however this is just one consequence in a spectrum of mild to severe neurological deficits. As we review, there are now clinical trials taking place worldwide targeting cerebral palsy with stem cell therapies. It will likely be many years before strong evidence-based results emerge from these trials. With such trials underway, it is both appropriate and timely to address the physiological basis for the efficacy of stem-like cells in preventing damage to, or regenerating, the newborn brain. Appropriate experimental animal models are best placed to deliver this information. Cell availability, the potential for immunological rejection, ethical and logistical considerations, together with the propensity for native cells to form terratomas, make it unlikely that embryonic or fetal stem cells will be practical. Fortunately, these issues do not pertain to the use of human amnion epithelial cells (hAECs, or umbilical cord blood (UCB stem cells that are readily and economically obtained from the placenta and umbilical cord discarded at birth. These cells have the potential for transplantation to the newborn where brain injury is diagnosed or even suspected. We will explore the novel characteristics of hAECs and undifferentiated UCB cells, as well as UCB-derived endothelial progenitor cells and mesenchymal stem cells, and how immunomodulation and anti-inflammatory properties are principal mechanisms of action that are common to these cells, and which in turn may ameliorate the cerebral hypoxia and inflammation that are final pathways in the pathogenesis of perinatal brain

  6. School District Uses Computer Aided Design and Drafting.

    Lorentz, Gordon S.

    1988-01-01

    Computer Aided Design and Drafting (CADD) programs are used to teach drafting at an Indiana high school. The school system's maintenance department shared use of the software and equipment to produce original drawings of school buildings. (MLF)

  7. Indiana Bat (Myotis sodalis) Draft Recovery Plan: First Revision

    US Fish and Wildlife Service, Department of the Interior — U.S. Fish and Wildlife Service's Draft recovery plan for Indiana bats, a Federally endangered species. First revision. The purpose of this draft recovery plan is to...

  8. The Physics of Bump Drafting in Car Racing

    Fiolhais, Miguel C. N.; Amor dos Santos, Susana

    2014-01-01

    The technique of bump drafting, also known as two-car drafting in motorsports, is analysed in the framework of Newtonian mechanics and simple aerodynamic drag forces. As an apparent unnatural effect that often pleases the enthusiasts of car racing, bump drafting provides a unique pedagogical opportunity for students to gain insights into the…

  9. 75 FR 57956 - Draft Revision of the Federalwide Assurance

    2010-09-23

    ... HUMAN SERVICES Draft Revision of the Federalwide Assurance AGENCY: Department of Health and Human... Assistant Secretary for Health, is announcing the availability of the draft revised Federalwide Assurance (FWA) form and Terms of Assurance, and is seeking comment on these draft documents. OHRP is...

  10. 76 FR 50231 - Mobile Medical Applications Draft Guidance; Public Workshop

    2011-08-12

    ... notice of availability for the draft guidance (76 FR 43689, July 21, 2011): FDA's recently- issued draft... workshop discussion, a ``mobile medical app'' is a mobile application that meets the definition of ``device... HUMAN SERVICES Food and Drug Administration Mobile Medical Applications Draft Guidance; Public...

  11. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October - December 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  12. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July - September 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  13. Supplement to the Surplus Plutonium Disposition Draft Environmental Impact Statement

    N/A

    1999-05-14

    services. The procurement process included the environmental review specified in DOE's NEPA regulations in 10 CFR 1021.216. The six reactors selected are Catawba Nuclear Station Units 1 and 2 in South Carolina McGuire Nuclear Station Units 1 and 2 in North Carolina, and North Anna Power Station Units 1 and 2 in Virginia. The Supplement describes the potential environmental impacts of using MOX fuel in these six specific reactors named in the DCS proposal as well as other program changes made since the SPD Draft EIS was published.

  14. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1989) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. Also included are a number of enforcement actions that had been previously resolved but not published in this NUREG. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  15. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1990) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. Also included are a number of enforcement actions that had been previously resolved but not published in this NUREG. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  16. Reviews.

    Adoption & Fostering, 1994

    1994-01-01

    Reviews 17 publications covering a variety of topics including abused disabled children; child placement; helping attachment disordered children; open adoption; family empowerment; teenage fostering; the Children Act of 1989 (Great Britain); family law; social services and child care law; and challenging racism in the early years. (TJQ)

  17. Reviews

    2002-07-01

    BOOK REVIEWS (353) Dr Dyer's Academy Further Advanced Physics Physics 11-14, with Biology 11-14 and Chemistry 11-14 Nelson Modular Science: Books 1 and 2 Key Science: Physics, 3rd Edition Nelson Science: Physics, 2nd Edition Physics for AQA: Separate Award, Coordinated Award Physical Processes: A Visual Approach WEB WATCH (359) Physics Favourites: John Miller's selection

  18. Review

    Prud’homme van Reine, W.F.

    1998-01-01

    The two published parts of the Desmid Flora of Austria are well-illustrated review volumes on a group of precious freshwater microalgae. Volume 1 contains a pretty, visual key to the genera, completed by figures of one or more characteristic species. In all keys of the separate genera many visual ai

  19. US Food and Drug Administration draft recommendations on radioactive contamination of food

    Recommendations on accidental radioactive contamination of human food were issued in 1982 by the Food and Drug Administration (FDA). The recommendations provided guidance to State and local government officials in the exercise of their respective authorities, and were applicable to emergency response planning and to the conduct of radiation protection activities associated with the production, processing, distribution, and use of human food accidentally contaminated with radioactive material. Review of the 1982 FDA recommendations, stimulated by the events following the 1986 accident at Chernobyl, indicated that it would be appropriate to update the recommendations to incorporate newer scientific information and radiation protection philosophy, to include experience gained since 1982, and to take into account international advances. This paper presents a brief outline of the FDA's approach to its draft revision. the most recent draft was circulated for interagency review in November 1994. Modification made in response to the comments received are included in this paper. 20 refs., 6 tabs

  20. Eicosanoid actions in insect immunology

    In this chapter we review eicosanoid actions in insect immunity. Eicosanoids are oxygenated metabolites of arachidonic acid (AA) and two other C20 polyunsaturated polyunsaturated fatty acids. Groups of eicosanoids include prostaglandins, lipoxygenase products and epoxyeicosatrienoic acids. These ...

  1. 78 FR 15931 - Sunshine Act Meeting; Request for Comments on Draft Evaluation of Recommended Practice on Fatigue...

    2013-03-13

    ... INVESTIGATION BOARD Sunshine Act Meeting; Request for Comments on Draft Evaluation of Recommended Practice on... issued an ANSI-approved Recommended Practice (RP 755) in April 2010. After review, the CSB staff found... Institute (API) and the United Steelworkers International Union (USW) in March 2007. This...

  2. 76 FR 55728 - Notice of the Extension of the Comment Period for the Draft Environmental Impact Report...

    2011-09-08

    ... High-Speed Rail Authority (Authority) is the lead state agency for the environmental review process..., electric powered, passenger rail, high-speed railroad along a 114-mile corridor between Fresno and.... ADDRESSES: Written comments on the Draft EIR/EIS should be sent to the California High-Speed Rail...

  3. 76 FR 72006 - Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon...

    2011-11-21

    ... COMMISSION Draft Interim Staff Guidance: Evaluations of Uranium Recovery Facility Surveys of Radon and Radon... Recovery Facility Surveys of Radon and Radon Progeny in Air and Demonstrations of Compliance with 10 CFR 20... that existing guidance does not sufficiently detail how the NRC staff reviews surveys of radon...

  4. Reviews

    Philip Barker

    1998-12-01

    Full Text Available There were two copy-editing blunders in Clive Betts's review, in ALT-J 5 (3, of Shirley Fletcher's Designing Competence-Based Training, one in paragraph 2 line 1, the other in paragraph 3 line 8. The errors (the result of the Editor, Gabriel Jacobs, trying to perform a final proof of the journal at lightning speed in order to meet the printing deadline, and not of any mistake on the part of either Philip Barker or the University of Wales Press hardly affected meaning, but the fact that they appeared in a review of a book on competence makes the embarrassment all the more telling. The Editor apologizes, and thanks eagle-eyed readers. He has decided to read the book in the hope that such errors will not recur.

  5. CFD modeling of a spouted bed with a porous draft tube

    Salar Azizi; Seyyed Hossein Hosseini; M. Moraveji; Goodarz Ahmadi

    2010-01-01

    Spouted bed with a porous draft tube is used for drying of grains and chemical products and thermal disinfestations process. This work provides a computational fluid dynamics (CFD) simulation of binary mixtures of glass particles in a spouted bed with a porous draft tube. The simulation used the multi-fluid Eulerian-Eulerian approach based on kinetic theory of granular flows, incorporating a kinetic-frictional constitutive model for dense assemblies of particulate solids and Gidaspow's drag model for the inter-action between gas and particles. Influences of solids mass fraction and inlet gas flow rate on pressure distribution, gas and particle velocities were studied. The modeling results were compared with the exper-imental work of Ishikura, Nagashima, and lde (2003) for the flow condition along the axis of the spouted bed. Good agreement between the modeling results and experimental data was observed.

  6. DRAFT CAREER PATH - DESCRIPTIONS AND EVALUATION GUIDE

    1999-01-01

    As indicated in the summary of the Standing Concertation Committee meeting of 3 March 1999, the Committee has approved the above draft guide concerning Career Paths II to VII on a test basis for at least one year.During this period, Personnel Division has been asked to monitor the applicability of this guide for possible future implementation (establishment of vacancies for recruitment, change of career path evaluations, salary survey comparisons) and to report back to the Standing Concertation Committee after approximately one year.Copies of the draft guide are available on request in divisional secretariats.Personnel DivisionTel.74480

  7. Review

    Van Den Hazel, H B; Kielland-Brandt, Morten; Winther, Jakob R.

    1996-01-01

    The yeast vacuole, which is equivalent to the lysosome of higher eukaryotes, is one of the best characterized degradative organelles. This review describes the biosynthesis and function of yeast vacuolar proteases. Most of these enzymes are delivered to the vacuole via the early compartments of the...... vacuolar proteolysis are described. Substrates of the vacuolar proteases are mostly imported via endocytosis or autophagocytosis, and vacuolar proteolysis appears to be mainly important under nutritional stress conditions and sporulation....

  8. Prioritization strategies for pandemic influenza vaccine in 27 countries of the European Union and the Global Health Security Action Group: a review

    Haas Walter

    2007-09-01

    Full Text Available Abstract Background Although there is rapid progress in vaccine research regarding influenza pandemic vaccines it is expected that pandemic influenza vaccine production can only start once the pandemic virus has been recognized. Therefore, pandemic vaccine capacity will be limited at least during the first phase of an influenza pandemic, requiring vaccine prioritization strategies. WHO recommends developing preliminary priorities for pandemic vaccine use. The goal of this review is to provide a thorough overview of pandemic vaccine prioritization concepts in the 27 European Union (EU member states and the four non-EU countries of the Global Health Security Action Group. Methods Between September and December 2006 data was collected for each country through two data sources: (i the national influenza pandemic plan; (ii contacting key persons involved in pandemic planning by email and/or phone and/or fax Results Twenty-six (84% countries had established at least one vaccine priority group. Most common reported vaccine priority groups were health care workers (HCW (100%, essential service providers (ESP (92% and high risk individuals (HRI (92%. Ranking of at least one vaccine priority group was done by 17 (65% of 26 countries. Fifteen (88% of these 17 countries including a ranking strategy, decided that HCW with close contact to influenza patients should be vaccinated first; in most countries followed and/or ranked equally by ESP and subsequently HRI. Rationales for prioritization were provided by 22 (85% of 26 countries that established vaccine priority groups. There was large variation in the phrasing and level of detailed specification of rationales. Seven (32% of 22 countries providing rationales clearly associated each vaccine priority group with the specific rationale. Ten (32% of the 31 countries studied countries have consulted and involved ethical experts to guide decisions related to vaccine prioritization. Conclusion In the majority of

  9. Radioactive waste isolation in salt: Peer review of the Office of Nuclear Waste Isolation's draft report on a multifactor test design to investigate uniform corrosion of low-carbon steel

    Paddock, R.A.; Lerman, A.; Ditmars, J.D.; Macdonald, D.D.; Peerenboom, J.P.; Was, G.S.; Harrison, W.

    1987-01-01

    This report documents Argonne National Laboratory's review of an internal technical memorandum prepared by Battelle Memorial Institute's Office of Nuclear Waste Isolation (ONWI) entitled Multifactor Test Design to Investigate Uniform Corrosion of Low-Carbon Steel in a Nuclear Waste Salt Repository Environment. The several major areas of concern identified by peer review panelists are important to the credibility of the test design proposed in the memorandum and are to adequately addressed there. These areas of concern, along with specific recommendations to improve their treatment, are discussed in detail in Sec. 2 of this report. The twenty recommendations, which were abstracted from those discussions, are presented essentially in the order in which they are introduced in Sec. 2.

  10. 46 CFR 169.755 - Draft marks and draft indicating systems.

    2010-10-01

    ... SCHOOL VESSELS Vessel Control, Miscellaneous Systems, and Equipment Markings § 169.755 Draft marks and... projections of the marks onto a vertical plane are of uniform height equal to the vertical spacing...

  11. The UK's Draft Guidance for Health in SEA in light of HIA community priorities and the UNECE SEA Protocol

    The Protocol on Strategic Environmental Assessment (SEA) to the United Nations Economic Commission for Europe (UNECE) Espoo Convention came into force on 11 July 2010. This Protocol, to which the European Union is party, gives a legal basis for enhanced attention to human health in the SEA process. In this context, the United Kingdom's (UK's) 2007 Draft Guidance on Health in Strategic Environmental Assessment represents an important early government-led effort to bring health issues and public health considerations more significantly into the SEA process. Since the UK is a worldwide leader in environmental and various other types of impact assessment, and since other countries may eventually consider its example in efforts to meet UNECE SEA Protocol requirements, scrutiny of its outputs is warranted. This paper thus examines the UK's Draft Guidance from both HIA academic and practitioner perspectives. First it assesses the extent to which the Draft Guidance reflects recent issues and lessons learned in the academic literature. In order to make the assessment, a meta-analysis of 70 HIA-related peer-reviewed articles was undertaken to extract authors' priority recommendations. These recommendations were subsequently compared with the contents of the Draft Guidance. Secondly, the Draft Guidance was assessed for its accordance with recommendations of the UNECE SEA Protocol background paper written by two HIA practitioners. Overall, the Draft Guidance's accordance with both sets of recommendations was found to be high, with only a few easily-remedied gaps. This evaluation suggests that the UK's Draft Guidance can be a useful starting point in the creation of future guidance on health in SEA in both the UK and other countries.

  12. BPA/Puget Power Northwest Washington Transmission Project. Supplemental Draft Environmental Impact Statement

    Bonneville Power Administration and Puget Sound Power ampersand Light Company propose to upgrade the existing high-voltage transmission system in the Whatcom and Skagit County area between the towns of Custer and Sedro Woolley, including within the City of Bellingham, starting in 1995. The upgrades of the interconnected 230-kV and 115-kV systems are needed to increase the import capacity on a nearby U.S.-Canada 500-kV intertie by about 850 megawatts (MW). BPA and Puget Power would share the increase in north-south transfer capability. An existing BPA 230-kV single-circuit, wood-pole H-frame transmission line would be upgraded to a 230-kV lattice-steel double-circuit line. A Draft Environmental Impact Statement (DEIS) for the project was issued in November 1993. New 1994 studies showed that other improvements to Puget Power's system, and the addition of local generation has lessened local reliability problems. Also in 1994, BPA reevaluated all existing projects with this goal in mind. BPA and Puget determined that benefits would still result from this project, and that additional transfer capacity and improved system integrity warrant the expenditures. Given the changes in need, BPA decided to issue a Supplemental DEIS, and provide a second public review-and-comment period. The proposed action is designated Option 1. Impacts would be low to moderate and localized. Effects on soils and water resources in sensitive areas would be low to moderate; there would be little increase in magnetic fields, noise levels would approximate existing levels; and land use and property value impacts would be low. Threatened and endangered species would not be adversely affected, and all proposed Sections in wetlands would be covered by Nationwide Permit. Visual and socioeconomic impacts would be low to moderate. No cultural resources listed on the National Register of Historic Places would be affected

  13. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1990) and includes copies of letters, notices, and orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  14. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  15. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  16. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1990) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  17. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  18. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April-June 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  19. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1989) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  20. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  1. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (January--March 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  2. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April--June 1990) and includes copies of letters, notices, and orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  3. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April--June 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  4. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1991) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  5. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (July--September 1993) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  6. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (October--December 1989) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  7. Enforcement actions: Significant actions resolved

    This compilation summarizes significant enforcement actions that have been resolved during one quarterly period (April--June 1992) and includes copies of letters, Notices, and Orders sent by the Nuclear Regulatory Commission to licensees with respect to these enforcement actions. It is anticipated that the information in this publication will be widely disseminated to managers and employees engaged in activities licensed by the NRC, so that actions can be taken to improve safety by avoiding future violations similar to those described in this publication

  8. IMPLICATIONS OF THE CURRENT EXPOSURE DRAFT ON AUDIT REPORTING

    George Silviu CORDOȘ

    2015-04-01

    Full Text Available The regulatory changes come as a response to perceived deficiencies in the postfinancial crisis, and their goal is to improve users' perception of the usefulness and quality of the audit report. The article approaches the subject of these proposals to revise the standards and their implications for the audit report. The article is divided into five parts: the first part the authors present a brief introduction to the subject matter; the second part presents the research methodology; the third part the authors present a review of the literature research; the fourth section presents an analysis of the responses of EU respondents to the Exposure Draft issued by the IAASB in July 2013 and the last part the authors present research findings, limitations and perspectives.

  9. Reduced order model of draft tube flow

    Swirling flow with compact coherent structures is very good candidate for proper orthogonal decomposition (POD), i.e. for decomposition into eigenmodes, which are the cornerstones of the flow field. Present paper focuses on POD of steady flows, which correspond to different operating points of Francis turbine draft tube flow. Set of eigenmodes is built using a limited number of snapshots from computational simulations. Resulting reduced order model (ROM) describes whole operating range of the draft tube. ROM enables to interpolate in between the operating points exploiting the knowledge about significance of particular eigenmodes and thus reconstruct the velocity field in any operating point within the given range. Practical example, which employs axisymmetric simulations of the draft tube flow, illustrates accuracy of ROM in regions without vortex breakdown together with need for higher resolution of the snapshot database close to location of sudden flow changes (e.g. vortex breakdown). ROM based on POD interpolation is very suitable tool for insight into flow physics of the draft tube flows (especially energy transfers in between different operating points), for supply of data for subsequent stability analysis or as an initialization database for advanced flow simulations

  10. Drafting International Commercial Agreements - a Primer

    Wautelet, Patrick

    2011-01-01

    This presentation is used as a basis for a course on drafting international commercial agreements. It is complemented by two cases studies. The course is mainly addressed to non lawyers and is hence rather practice than law oriented. The course is not linked to one jurisdiction or one type of contract in particular, but attempts to address general issues related to international commercial agreements.

  11. Parallel-End-Point Drafting Compass

    Cronander, J.

    1986-01-01

    Parallelogram linkage ensures greater accuracy in drafting and scribing. Two members of arm of compass remain parallel for all angles pair makes with hub axis. They maintain opposing end members in parallelism. Parallelogram-linkage principle used on dividers as well as on compasses.

  12. Drafting. Advanced Print Reading--Electrical.

    Oregon State Dept. of Education, Salem.

    This document is a workbook for drafting students learning advanced print reading for electricity applications. The workbook contains seven units covering the following material: architectural working drawings; architectural symbols and dimensions; basic architectural electrical symbols; wiring symbols; riser diagrams; schematic diagrams; and…

  13. 75 FR 63851 - Draft Friends Organizations Policy

    2010-10-18

    ... Fish and Wildlife Service Draft Friends Organizations Policy AGENCY: Fish and Wildlife Service... effectiveness in achieving the Service's mission through partnerships with Friends organizations (volunteer/advocate). Today, Friends organizations play a vital role in helping to fulfill the Service's mission...

  14. Draft Genome Sequence of Lactobacillus rhamnosus 2166.

    Karlyshev, Andrey V.; Melnikov, Vyacheslav G.; Kosarev, Igor V.; Abramov, Vyacheslav M.

    2014-01-01

    In this report, we present a draft sequence of the genome of Lactobacillus rhamnosus strain 2166, a potential novel probiotic. Genome annotation and read mapping onto a reference genome of L. rhamnosus strain GG allowed for the identification of the differences and similarities in the genomic contents and gene arrangements of these strains.

  15. Incorporating CAD Instruction into the Drafting Curriculum.

    Yuen, Steve Chi-Yin

    1990-01-01

    If education is to meet the challenged posed by the U.S. productivity crisis and the large number of computer-assisted design (CAD) workstations forecast as necessary in the future, schools must integrate CAD into the drafting curriculum and become aggressive in providing CAD training. Teachers need to maintain close contact with local industries…

  16. First Draft of the Research Agenda

    Dahl, Hanne Marlene; Pieper, Michael; Fahnøe, Kristian

    This report is a draft of a research agenda that the consortium INNOSERV has provided to the European Commission. It is the result of the work of researchers and insights provided by users, practitioners, experts and policy-makers involving around 20 examples of innovative practices from differen...... context, New Technologies and Measuring outcomes, quality and challenges....

  17. Illinois Occupational Skill Standards: Architectural Drafting Cluster.

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    This document, which is intended as a guide for work force preparation program providers, details the Illinois occupational skill standards for programs preparing students for employment in occupations in the architectural drafting cluster. The document begins with a brief overview of the Illinois perspective on occupational skill standards and…

  18. Illinois Occupational Skill Standards: Mechanical Drafting Cluster.

    Illinois Occupational Skill Standards and Credentialing Council, Carbondale.

    This document, which is intended as a guide for work force preparation program providers, details the Illinois occupational skill standards for programs preparing students for employment in occupations in the mechanical drafting cluster. The document begins with a brief overview of the Illinois perspective on occupational skill standards and…

  19. 75 FR 57958 - Solicitation of Written Comments on Draft Tier 2 Strategies/Modules for Inclusion in the “HHS...

    2010-09-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND HUMAN SERVICES Solicitation of Written Comments on Draft Tier 2 Strategies/ Modules for Inclusion in the ``HHS Action Plan to Prevent Healthcare- Associated Infections'' AGENCY: Department of Health and...

  20. Draft supplement to final environmental statement related to construction and operation of Clinch River Breeder Reactor Plant. Docket No. 50-537

    Information is presented concerning the site and environs; facility description; environmental impacts due to construction; environmental impacts of plant operation; environmental measurement and monitoring programs; environmental impacts of postulated accidents; need for the proposed facility; alternatives; evaluation of the proposed action; and discussion of comments received on the draft environmental statement

  1. CFD based draft tube hydraulic design optimization

    The draft tube design of a hydraulic turbine, particularly in low to medium head applications, plays an important role in determining the efficiency and power characteristics of the overall machine, since an important proportion of the available energy, being in kinetic form leaving the runner, needs to be recovered by the draft tube into static head. For large units, these efficiency and power characteristics can equate to large sums of money when considering the anticipated selling price of the energy produced over the machine's life-cycle. This same draft tube design is also a key factor in determining the overall civil costs of the powerhouse, primarily in excavation and concreting, which can amount to similar orders of magnitude as the price of the energy produced. Therefore, there is a need to find the optimum compromise between these two conflicting requirements. In this paper, an elaborate approach is described for dealing with this optimization problem. First, the draft tube's detailed geometry is defined as a function of a comprehensive set of design parameters (about 20 of which a subset is allowed to vary during the optimization process) and are then used in a non-uniform rational B-spline based geometric modeller to fully define the wetted surfaces geometry. Since the performance of the draft tube is largely governed by 3D viscous effects, such as boundary layer separation from the walls and swirling flow characteristics, which in turn governs the portion of the available kinetic energy which will be converted into pressure, a full 3D meshing and Navier-Stokes analysis is performed for each design. What makes this even more challenging is the fact that the inlet velocity distribution to the draft tube is governed by the runner at each of the various operating conditions that are of interest for the exploitation of the powerhouse. In order to determine these inlet conditions, a combined steady-state runner and an initial draft tube analysis

  2. Corrective actions

    The variety of corrective actions which have been attempted at many radioactive waste disposal sites points to less than ideal performance by present-day standards at many closed and presently-operating sites. In humid regions, most of the problems have encompassed some kind of water intrusion into the buried waste. In arid regions, the problems have centered on trench subsidence and intrusion by plant roots and animals. It is overwhelmingly apparent that any protective barrier for the buried waste, whether for water or biological intrusion, will depend on stable support from the underlying burial trenches. Trench subsidence must be halted, prevented, or circumscribed in some manner to assure this necessary long-term support. Final corrective actions will differ considerably from site to site, depending on unique geological, pedological, and meteorological environments. In the meantime, many of the shorter-term corrective actions described in this chapter can be implemented as immediate needs dictate

  3. An Interim Report on NASA's Draft Space Technology Roadmaps

    2011-01-01

    NASA has developed a set of 14 draft roadmaps to guide the development of space technologies under the leadership of the NASA Office of the Chief Technologist (OCT). Each of these roadmaps focuses on a particular technology area (TA). The roadmaps are intended to foster the development of advanced technologies and concepts that address NASA's needs and contribute to other aerospace and national needs. OCT requested that the National Research Council conduct a study to review the draft roadmaps, gather and assess relevant community input, and make recommendations and suggest priorities to inform NASA's decisions as it finalizes its roadmaps. The statement of task states that "based on the results of the community input and its own deliberations, the steering committee will prepare a brief interim report that addresses high-level issues associated with the roadmaps, such as the advisability of modifying the number or technical focus of the draft NASA roadmaps." This interim report, which does not include formal recommendations, addresses that one element of the study charge. NASA requested this interim report so that it would have the opportunity to make an early start in modifying the draft roadmaps based on feedback from the panels and steering committee. The final report will address all other tasks in the statement of task. In particular, the final report will include a prioritization of technologies, will describe in detail the prioritization process and criteria, and will include specific recommendations on a variety of topics, including many of the topics mentioned in this interim report. In developing both this interim report and the final report to come, the steering committee draws on the work of six study panels organized by technical area, loosely following the organization of the 14 roadmaps, as follows: A Panel 1: Propulsion and Power TA01 Launch Propulsion Systems TA02 In-Space Propulsion Technologies TA03 Space Power and Energy Storage Systems TA13

  4. 75 FR 20595 - Review of the Secondary National Ambient Air Quality Standards for Oxides of Nitrogen and Oxides...

    2010-04-20

    ...The EPA is announcing an extension of the public comment period for a draft assessment document titled, Policy Assessment for the Review of the Secondary National Ambient Air Quality Standards for Oxides of Nitrogen and Oxides of Sulfur: First External Review Draft (75 FR 11877; March 12, 2010). The comment period was originally scheduled to end on April 29, 2010. The extended comment period......

  5. Review of Literature for Model Assisted Probability of Detection

    Meyer, Ryan M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Crawford, Susan L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lareau, John P. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Anderson, Michael T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-09-30

    This is a draft technical letter report for NRC client documenting a literature review of model assisted probability of detection (MAPOD) for potential application to nuclear power plant components for improvement of field NDE performance estimations.

  6. Willed action and its impairments.

    Jahanshahi, M

    1998-09-01

    Actions are goal-directed behaviours that usually involve movem ent. There is evidence that intentional self-generated actions (willed actions) are controlled differently from routine, stereotyped actions that are externally triggered by environmental stimuli. We review evidence from investigations using positron emission tomography (PET), recordings of movement-related cortical potentials (MRCPs) or transcranial magnetic stimulation (TMS), and conclude that willed actions are controlled by a network of frontal cortical (dorsolateral prefrontal cortex, supplementary motor area, anterior cingulate) and subcortical (thalamus and basal ganglia) areas. We also consider evidence suggesting that some of the cognitive and motor deficits of patients with frontal lesions, Parkinson's disease, or schizophrenia as well as apathy and abulia and rarer phenomena such as primary obsessional slowness can be considered as reflecting im pairment of willed actions. We propose that the concept of a willed action system based on the frontostriatal circuits provides a useful framework for integrating the cognitive, motor, and motivational deficits found in these disorders. Problems remaining to be resolved include: identification of the component processes of willed actions; the specific and differential role played by each of the frontal cortical and subcortical areas in the control of willed actions; the specific mechanisms of impairm ent of willed actions in Parkinson's disease, schizophrenia, and frontal damage; and the precise role of the neurotransmitter dopamine in the willed action system. PMID:22448836

  7. Draft environmental statement related to the operation of Millstone Nuclear Power Station, Unit No. 3 (Docket No. 50-423)

    This Draft Environmental Statement contains the second assessment of the environmental impact associated with the operation of Millstone Nuclear Power Station, Unit 3, pursuant to the National Environmental Policy Act of 1969 (NEPA) and Title 10 of the Code of Federal Regulations, Part 51, as amended, of the Nuclear Regulatory Commission regulations. This statement examines the environment, environmental consequences and mitigating actions, and environmental and economic benefits and costs

  8. Identities-in-action

    Stentoft, Diana; Valero, Paola

    2009-01-01

    The notion of identity is often used in mathematics education research in an attempt to link individual and social understandings of mathematical learning. In this paper we review existing research making use of the notion of identity, and we point to some of the strengths and weaknesses in the w...... identities in action allows us to bring attention to what is normally considered as ”noise” or ”impossibilities” in our understandings of mathematics education and classroom interaction....

  9. Overview of remedial action technology development milestone D

    The work on remedial action technology development has the same general bases as that on improved shallow land burial technology development. The major components of work aimed at remedial action technology development involve the following general problem areas: (1) water movement; (2) subsidence; (3) erosion; (4) intrusion; and (5) radionuclide migration. Each of these components are addressed in terms of its content and ongoing research, development and demonstration work. The four principal sites active in the remedial action technology development work of the Low-Level Waste Management Program are: Oak Ridge National Laboratory (ORNL); Los Alamo National Laboratory (LANL); Rockwell Hanford Operations (RHO); and Savannah River Laboratory (SRL). The final remedial action manual is to be prepared by December of 1984. Typical important deliverables for this activity are as follows: (1) Draft State-of-the-Art Remedial Action Manual - ORNL - 6/81; (2) Draft Remedial Action Criteria - ORNL - 9/81; (3) Report on Barriers - LANL - 9/83; (4) Report on Water Management - ORNL - 9/83; (5) Reports on Subsidence Studies - LANL and ORNL - 9/84; (6) Final Remedial Action Manual - ORNL - 12/84

  10. A Meta-Analytic Review of the Theories of Reasoned Action and Planned Behavior in Physical Activity: Predictive Validity and the Contribution of Additional Variables.

    Hagger, Martin S.; Chatzisarantis, Nikos L. D.; Biddle, Stuart J. H.

    2002-01-01

    Examined relations between behavior, intentions, attitudes, subjective norms, perceived behavioral control, self-efficacy, and past behaviors using the Theories of Reasoned Action (TRA) and Planned Behavior (TPB) in physical activity. This quantitative integration of the physical activity literature supported the major relationships of the…

  11. Action Research

    Milton-Brkich, Katie Lynn; Shumbera, Kristen; Beran, Becky

    2010-01-01

    Defined as "any systemic inquiry conducted by teachers... for the purpose of gathering information about how their particular schools operate, how they teach, and how their students learn" (Mertler, 2009), "action research" is empowering and professional research done by teachers to inform and improves their own practices. Although there are many…

  12. China's Actions

    2010-01-01

    @@ China's National Development and Reform Commission publicized the country's policies and actions for addressing climate change in a report released on November 26,2009.The report highlighted China's efforts in cutting greenhouse gas emissions in 2009 by: (1)Rigorously checking the blind expansion of its energy-and pollution-intensive industries.

  13. Actions Needed to Ensure Scientific and Technical Information is Adequately Reviewed at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center

    2008-01-01

    This audit was initiated in response to a hotline complaint regarding the review, approval, and release of scientific and technical information (STI) at Johnson Space Center. The complainant alleged that Johnson personnel conducting export control reviews of STI were not fully qualified to conduct those reviews and that the reviews often did not occur until after the STI had been publicly released. NASA guidance requires that STI, defined as the results of basic and applied scientific, technical, and related engineering research and development, undergo certain reviews prior to being released outside of NASA or to audiences that include foreign nationals. The process includes technical, national security, export control, copyright, and trade secret (e.g., proprietary data) reviews. The review process was designed to preclude the inappropriate dissemination of sensitive information while ensuring that NASA complies with a requirement of the National Aeronautics and Space Act of 1958 (the Space Act)1 to provide for the widest practicable and appropriate dissemination of information resulting from NASA research activities. We focused our audit on evaluating the STI review process: specifically, determining whether the roles and responsibilities for the review, approval, and release of STI were adequately defined and documented in NASA and Center-level guidance and whether that guidance was effectively implemented at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center. Johnson was included in the review because it was the source of the initial complaint, and Goddard, Langley, and Marshall were included because those Centers consistently produce significant amounts of STI.

  14. 77 FR 40586 - Draft NIST Interagency Report (NISTIR) 7823, Advanced Metering Infrastructure Smart Meter...

    2012-07-10

    ... Metering Infrastructure Smart Meter Upgradeability Test Framework; Request for Comments AGENCY: National... Metering Infrastructure Smart Meter Upgradeability Test Framework (Draft NISTIR 7823). This draft document... process for the Advanced Metering Infrastructure (AMI) Smart Meters. The target audience for Draft...

  15. 78 FR 74162 - Draft Criminal Justice Offender Tracking System Standard and Companion Documents

    2013-12-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Office of Justice Programs Draft Criminal Justice Offender Tracking System Standard and Companion Documents... draft documents: (1) A draft standard entitled, ``Criminal Justice Offender Tracking System...

  16. 40 CFR 300.415 - Removal action.

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false Removal action. 300.415 Section 300... PLAN Hazardous Substance Response § 300.415 Removal action. (a)(1) In determining the appropriate extent of action to be taken in response to a given release, the lead agency shall first review...

  17. Milestone 4.1 ∙ First draft on complemented LCA methodology

    Larsen, Henrik Fred; Olsen, Stig Irving; Hauschild, Michael Zwicky

    this methodology is presented here. Special issues of waste water have been addressed by including novel development on LCIA methodology for possible impact from pathogens and whole effluent toxicity. Special focus is also allocated to micropollutants with specific toxic mode of action (i.e. endocrine...... al. 1997, Hauschild and Wenzel 1998) for which the impact assessment on toxicity is PNEC based. However, in order to include the newest development on especially best available practice as regards ecotoxicity a new revised and updated EDIP 200X LCIA methodology has been developed. A first draft of...

  18. Draft environment statement related to operation of Moab uranium mill (Grand County, Utah)

    This draft environmental impact statement was prepared by the staff of the U.S. Nuclear Regulatory Commission and issued by the Commission's Office of Nuclear Material Safety and Safeguards. The proposed action is the continuation of Source Material License SUA-917 issued to Atlas Corporation for the operation of the Atlas Uranium Mill in Grand County, Utah, near Moab (Docket No. 40-3453). This authorizes a 600-ton (450-MT) per day acid leach circuit (for recovery of vanadium as well as uranium) and a 600-ton (450-MT) per day alkaline leach circuit

  19. Puget Sound area electric reliability plan. Draft environmental impact statement

    1991-09-01

    The Puget Sound Area Electric Reliability Plan Draft Environmental Impact Statement (DEIS) identifies the alternatives for solving a power system problem in the Puget Sound area. This Plan is undertaken by Bonneville Power Administration (BPA), Puget Sound Power & Light, Seattle City Light, Snohomish Public Utility District No. 1 (PUD), and Tacoma Public Utilities. The Plan consists of potential actions in Puget Sound and other areas in the State of Washington. A specific need exists in the Puget Sound area for balance between east-west transmission capacity and the increasing demand to import power generated east of the Cascades. At certain times of the year, there is more demand for power than the electric system can supply in the Puget Sound area. This high demand, called peak demand, occurs during the winter months when unusually cold weather increases electricity use for heating. The existing power system can supply enough power if no emergencies occur. However, during emergencies, the system will not operate properly. As demand grows, the system becomes more strained. To meet demand, the rate of growth of demand must be reduced or the ability to serve the demand must be increased, or both. The plan to balance Puget Sound`s power demand and supply has these purposes: The plan should define a set of actions that would accommodate ten years of load growth (1994--2003). Federal and State environmental quality requirements should be met. The plan should be consistent with the plans of the Northwest Power Planning Council. The plan should serve as a consensus guideline for coordinated utility action. The plan should be flexible to accommodate uncertainties and differing utility needs. The plan should balance environmental impacts and economic costs. The plan should provide electric system reliability consistent with customer expectations. 29 figs., 24 tabs.

  20. Puget Sound Area Electric Reliability Plan : Draft Environmental Impact State.

    United States. Bonneville Power Administration.

    1991-09-01

    The Puget Sound Area Electric Reliability Plan Draft Environmental Impact Statement (DEIS) identifies the alternatives for solving a power system problem in the Puget Sound area. This Plan is undertaken by Bonneville Power Administration (BPA), Puget Sound Power Light, Seattle City Light, Snohomish Public Utility District No. 1 (PUD), and Tacoma Public Utilities. The Plan consists of potential actions in Puget Sound and other areas in the State of Washington. A specific need exists in the Puget Sound area for balance between east-west transmission capacity and the increasing demand to import power generated east of the Cascades. At certain times of the year, there is more demand for power than the electric system can supply in the Puget Sound area. This high demand, called peak demand, occurs during the winter months when unusually cold weather increases electricity use for heating. The existing power system can supply enough power if no emergencies occur. However, during emergencies, the system will not operate properly. As demand grows, the system becomes more strained. To meet demand, the rate of growth of demand must be reduced or the ability to serve the demand must be increased, or both. The plan to balance Puget Sound's power demand and supply has these purposes: The plan should define a set of actions that would accommodate ten years of load growth (1994--2003). Federal and State environmental quality requirements should be met. The plan should be consistent with the plans of the Northwest Power Planning Council. The plan should serve as a consensus guideline for coordinated utility action. The plan should be flexible to accommodate uncertainties and differing utility needs. The plan should balance environmental impacts and economic costs. The plan should provide electric system reliability consistent with customer expectations. 29 figs., 24 tabs.