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Sample records for actinium 229

  1. Extraction of actinium with di-(2-ethylhexyl)phosphoric acid from hydrochloric and nitric acid solutions

    The extraction of actinium with HDEHP from Cl- and NO3- systems has been investigated. It was found that extraction of actinium from HCl solutions is much better than from HNO3 solutions. Stability constants of actinium complexes Ac(X-)+2 with Cl- and NO3- ligands were determined. Our results show that the actinium formed less stable complexes with Cl- than with NO3- ligands. 5 refs., 3 figs., 1 tab. (author)

  2. The sorption of polonium, actinium and protactinium onto geological materials

    This paper describes a combined experimental and modeling program of generic sorption studies to increase confidence in the performance assessment for a potential high-level radioactive waste repository in Japan. The sorption of polonium, actinium and protactinium onto geological materials has been investigated. Sorption of these radioelements onto bentonite, tuff and granodiorite from equilibrated de-ionized water was studied under reducing conditions at room temperature. In addition, the sorption of actinium and protactinium was investigated at 60 C. Thermodynamic chemical modeling was carried out to aid interpretation of the results

  3. Discovery of the actinium, thorium, protactinium, and uranium isotopes

    Fry, C; Thoennessen, M

    2012-01-01

    Currently, 31 actinium, 31 thorium, 28 protactinium, and 23 uranium isotopes have so far been observed; the discovery of these isotopes is discussed. For each isotope a brief summary of the first refereed publication, including the production and identification method, is presented.

  4. Separation of Actinium 227 from the uranium minerals

    The purpose of this work was to separate Actinium 227, whose content is 18%, from the mineral carnotite found in Gomez Chihuahua mountain range in Mexico. The mineral before processing is is pre-concentrated and passed, first through anionic exchange resins, later the eluate obtained is passed through cationic resins. The resins were 20-50 MESH QOWEX and 100-200 MESH 50 X 8-20 in some cased 200-400 MESH AG 50W-X8, 1X8 in other cases. The eluates from the ionic exchange were electrodeposited on stainless steel polished disc cathode and platinum electrode as anode; under a current ODF 10mA for 2.5 to 5 hours and of 100mA for .5 of an hour. it was possible to identify the Actinium 227 by means of its descendents, TH-227 and RA-223, through alpha spectroscopy. Due to the radiochemical purity which the electro deposits were obtained the Actinium 227 was low and was not quantitatively determined. A large majority of the members of the natural radioactive series 3 were identified and even alpha energies reported in the literature with very low percentages of non-identified emissions were observed. We conclude that a more precise study is needed concerning ionic exchange and electrodeposit to obtain an Actinium 227 of radiochemical purity. (Author)

  5. Spectroscopic and computational investigation of actinium coordination chemistry.

    Ferrier, Maryline G; Batista, Enrique R; Berg, John M; Birnbaum, Eva R; Cross, Justin N; Engle, Jonathan W; La Pierre, Henry S; Kozimor, Stosh A; Lezama Pacheco, Juan S; Stein, Benjamin W; Stieber, S Chantal E; Wilson, Justin J

    2016-01-01

    Actinium-225 is a promising isotope for targeted-α therapy. Unfortunately, progress in developing chelators for medicinal applications has been hindered by a limited understanding of actinium chemistry. This knowledge gap is primarily associated with handling actinium, as it is highly radioactive and in short supply. Hence, Ac(III) reactivity is often inferred from the lanthanides and minor actinides (that is, Am, Cm), with limited success. Here we overcome these challenges and characterize actinium in HCl solutions using X-ray absorption spectroscopy and molecular dynamics density functional theory. The Ac-Cl and Ac-OH2O distances are measured to be 2.95(3) and 2.59(3) Å, respectively. The X-ray absorption spectroscopy comparisons between Ac(III) and Am(III) in HCl solutions indicate Ac(III) coordinates more inner-sphere Cl(1-) ligands (3.2±1.1) than Am(III) (0.8±0.3). These results imply diverse reactivity for the +3 actinides and highlight the unexpected and unique Ac(III) chemical behaviour. PMID:27531582

  6. Production of high-purity radium-223 from legacy actinium-beryllium neutron sources.

    Soderquist, Chuck Z; McNamara, Bruce K; Fisher, Darrell R

    2012-07-01

    Radium-223 is a short-lived alpha-particle-emitting radionuclide with potential applications in cancer treatment. Research to develop new radiopharmaceuticals employing (223)Ra has been hindered by poor availability due to the small quantities of parent actinium-227 available world-wide. The purpose of this study was to develop innovative and cost-effective methods to obtain high-purity (223)Ra from (227)Ac. We obtained (227)Ac from two surplus actinium-beryllium neutron generators. We retrieved the actinium/beryllium buttons from the sources and dissolved them in a sulfuric-nitric acid solution. A crude actinium solid was recovered from the solution by coprecipitation with thorium fluoride, leaving beryllium in solution. The crude actinium was purified to provide about 40 milligrams of actinium nitrate using anion exchange in methanol-water-nitric acid solution. The purified actinium was then used to generate high-purity (223)Ra. We extracted (223)Ra using anion exchange in a methanol-water-nitric acid solution. After the radium was separated, actinium and thorium were then eluted from the column and dried for interim storage. This single-pass separation produces high purity, carrier-free (223)Ra product, and does not disturb the (227)Ac/(227)Th equilibrium. A high purity, carrier-free (227)Th was also obtained from the actinium using a similar anion exchange in nitric acid. These methods enable efficient production of (223)Ra for research and new alpha-emitter radiopharmaceutical development. PMID:22697483

  7. Radium, thorium, and actinium extraction from seawater using an improved manganese-oxide-coated fiber

    Laboratory experiments were conducted to determine the efficiency with which improved manganese-oxide-coated acrylic fibers extract radium, thorium, and actinium from seawater. Tests were made using surface seawater spiked with 227Ac, 227Th and 223Ra. For sample volumes of approximately 30 liters and flow rates up to 0.5 liters per minute, radium and actinium are removed quantitatively. Approximately 80-95% of the thorium is removed under these same conditions. (Auth.)

  8. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    Harvey, James T.; Nolen, Jerry; Vandergrift, George; Gomes, Itacil; Kroc, Tom; Horwitz, Phil; McAlister, Dan; Bowers, Del; Sullivan, Vivian; Greene, John

    2011-12-30

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces {approx}100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 Ge

  9. Production of Actinium-225 via High Energy Proton Induced Spallation of Thorium-232

    The science of cancer research is currently expanding its use of alpha particle emitting radioisotopes. Coupled with the discovery and proliferation of molecular species that seek out and attach to tumors, new therapy and diagnostics are being developed to enhance the treatment of cancer and other diseases. This latest technology is commonly referred to as Alpha Immunotherapy (AIT). Actinium-225/Bismuth-213 is a parent/daughter alpha-emitting radioisotope pair that is highly sought after because of the potential for treating numerous diseases and its ability to be chemically compatible with many known and widely used carrier molecules (such as monoclonal antibodies and proteins/peptides). Unfortunately, the worldwide supply of actinium-225 is limited to about 1,000mCi annually and most of that is currently spoken for, thus limiting the ability of this radioisotope pair to enter into research and subsequently clinical trials. The route proposed herein utilizes high energy protons to produce actinium-225 via spallation of a thorium-232 target. As part of previous R and D efforts carried out at Argonne National Laboratory recently in support of the proposed US FRIB facility, it was shown that a very effective production mechanism for actinium-225 is spallation of thorium-232 by high energy proton beams. The base-line simulation for the production rate of actinium-225 by this reaction mechanism is 8E12 atoms per second at 200 MeV proton beam energy with 50 g/cm2 thorium target and 100 kW beam power. An irradiation of one actinium-225 half-life (10 days) produces ∼100 Ci of actinium-225. For a given beam current the reaction cross section increases slightly with energy to about 400 MeV and then decreases slightly for beam energies in the several GeV regime. The object of this effort is to refine the simulations at proton beam energies of 400 MeV and above up to about 8 GeV. Once completed, the simulations will be experimentally verified using 400 MeV and 8 GeV protons

  10. 22 CFR 229.310 - Recruitment.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Recruitment. 229.310 Section 229.310 Foreign... and Recruitment Prohibited § 229.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 229.300 through 229.310 apply shall not discriminate on the basis of sex in the recruitment...

  11. 49 CFR 229.17 - Accident reports.

    2010-10-01

    ... CFR part 225. ... 49 Transportation 4 2010-10-01 2010-10-01 false Accident reports. 229.17 Section 229.17..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS General § 229.17 Accident reports. (a)...

  12. Neutron-Induced Fission of Actinium-227, Protactinium-231 and Neptunium-237: Mass Distribution

    Results of radiochemical studies on the mass distribution in the neutron-induced fission of actinium-227, protactinium-231 and neptunium-237 have been presented. This work has been carried out as part of a programme to determine the mass distribution in the fission of heavy elements as a function of Z and A. All irradiations have been carried out in the core of the swimming-pool type reactor APSARA with cadmium shielding wherever necessary. Relative yields of several fission product nuclides have been obtained by a method involving a comparison of the fission product activities from the respective targets with those formed from uranium-235 simultaneously irradiated. Thermal-neutron fission yields of uranium-235 have been assumed. These results indicate a predominantly asymmetric mass distribution in all the three cases, and also a distinct though small symmetric peak in the case of actinium-227. (author)

  13. A new method for the determination of low-level actinium-227 in geological samples

    We developed a new method for the determination of 227Ac in geological samples. The method uses extraction chromatographic techniques and alpha-spectrometry and is applicable for a range of natural matrices. Here we report on the procedure and results of the analysis of water (fresh and seawater) and rock samples. Water samples were acidified and rock samples underwent total dissolution via acid leaching. A DGA (N,N,N',N'-tetra-n-octyldiglycolamide) extraction chromatographic column was used for the separation of actinium. The actinium fraction was prepared for alpha spectrometric measurement via cerium fluoride micro-precipitation. Recoveries of actinium in water samples were 80 ± 8 % (number of analyses n = 14) and in rock samples 70 ± 12 % (n = 30). The minimum detectable activities (MDA) were 0.017-0.5 Bq kg-1 for both matrices. Rock sample 227Ac activities ranged from 0.17 to 8.3 Bq kg-1 and water sample activities ranged from below MDA values to 14 Bq kg-1of 227Ac. From the analysis of several standard rock and water samples with the method we found very good agreement between our results and certified values. (author)

  14. Reactor production of Thorium-229.

    Hogle, Susan; Boll, Rose Ann; Murphy, Karen; Denton, David; Owens, Allison; Haverlock, Tamara J; Garland, Marc; Mirzadeh, Saed

    2016-08-01

    Limited availability of (229)Th for clinical applications of (213)Bi necessitates investigation of alternative production routes. In reactor production, (229)Th is produced from neutron transmutation of (226)Ra, (228)Ra, (227)Ac and (228)Th. Irradiations of (226)Ra, (228)Ra, and (227)Ac targets at the Oak Ridge National Laboratory High Flux Isotope Reactor result in yields of (229)Th at 26 days of 74.0±7.4MBq/g, 260±10MBq/g, and 1200±50MBq/g, respectively. Intermediate radionuclide yields and cross sections are also studied. PMID:27163437

  15. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    Momeni, M.H.

    1981-09-01

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore.

  16. Analysis of the gamma spectra of the uranium, actinium, and thorium decay series

    This report describes the identification of radionuclides in the uranium, actinium, and thorium series by analysis of gamma spectra in the energy range of 40 to 1400 keV. Energies and absolute efficiencies for each gamma line were measured by means of a high-resolution germanium detector and compared with those in the literature. A gamma spectroscopy method, which utilizes an on-line computer for deconvolution of spectra, search and identification of each line, and estimation of activity for each radionuclide, was used to analyze soil and uranium tailings, and ore

  17. 49 CFR 229.61 - Draft system.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Draft system. 229.61 Section 229.61 Transportation... TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Draft System § 229.61 Draft system. (a) A.... Suspension System...

  18. 22 CFR 229.525 - Fringe benefits.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Fringe benefits. 229.525 Section 229.525... Employment in Education Programs or Activities Prohibited § 229.525 Fringe benefits. (a) “Fringe benefits” defined. For purposes of these Title IX regulations, fringe benefits means: Any medical,...

  19. 22 CFR 229.405 - Housing.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Housing. 229.405 Section 229.405 Foreign... Programs or Activities Prohibited § 229.405 Housing. (a) Generally. A recipient shall not, on the basis of... services or benefits related to housing, except as provided in this section (including housing...

  20. 22 CFR 229.500 - Employment.

    2010-04-01

    ... in Education Programs or Activities Prohibited § 229.500 Employment. (a) General. (1) No person shall... assistance. (2) A recipient shall make all employment decisions in any education program or activity operated... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Employment. 229.500 Section 229.500...

  1. 22 CFR 229.510 - Recruitment.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Recruitment. 229.510 Section 229.510 Foreign... in Education Programs or Activities Prohibited § 229.510 Recruitment. (a) Nondiscriminatory recruitment and hiring. A recipient shall not discriminate on the basis of sex in the recruitment and...

  2. 32 CFR 229.19 - Report.

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Report. 229.19 Section 229.19 National Defense... ARCHAEOLOGICAL RESOURCES: UNIFORM REGULATIONS § 229.19 Report. (a) Each Federal land manager, when requested by... comply with section 13 of the Act and comprehensively report on activities carried out under...

  3. 12 CFR 229.57 - Consumer awareness.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Consumer awareness. 229.57 Section 229.57 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Substitute Checks § 229.57 Consumer...

  4. 12 CFR 229.12 - Availability schedule.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Availability schedule. 229.12 Section 229.12... Availability Policies § 229.12 Availability schedule. (a) Effective date. The availability schedule contained...)(1)(vii). (e) Extension of schedule for certain deposits in Alaska, Hawaii, Puerto Rico, and the...

  5. 49 CFR 234.229 - Shunting sensitivity.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Shunting sensitivity. 234.229 Section 234.229 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION..., Inspection, and Testing Maintenance Standards § 234.229 Shunting sensitivity. Each highway-rail...

  6. In-source laser spectroscopy developments at TRILIS—towards spectroscopy on actinium and scandium

    Resonance Ionization Laser Ion Sources (RILIS) have become a versatile tool for production and study of exotic nuclides at Isotope Separator On-Line (ISOL) facilities such as ISAC at TRIUMF. The recent development and addition of a grating tuned spectroscopy laser to the TRIUMF RILIS solid state laser system allows for wide range spectral scans to investigate atomic structures on short lived isotopes, e.g., those from the element actinium, produced in uranium targets at ISAC. In addition, development of new and improved laser ionization schemes for rare isotope production at ISAC is ongoing. Here spectroscopic studies on bound states, Rydberg states and autoionizing (AI) resonances on scandium using the existing off-line capabilities are reported. These results allowed to identify a suitable ionization scheme for scandium via excitation into an autoionizing state at 58,104 cm − 1 which has subsequently been used for ionization of on-line produced exotic scandium isotopes.

  7. 22 CFR 229.305 - Preference in admission.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Preference in admission. 229.305 Section 229... in Admission and Recruitment Prohibited § 229.305 Preference in admission. A recipient to which §§ 229.300 through 229.310 apply shall not give preference to applicants for admission, on the basis...

  8. Production of thorium-229 using helium nuclei

    Mirzadeh, Saed [Knoxville, TN; Garland, Marc Alan [Knoxville, TN

    2010-12-14

    A method for producing .sup.229Th includes the steps of providing .sup.226Ra as a target material, and bombarding the target material with alpha particles, helium-3, or neutrons to form .sup.229Th. When neutrons are used, the neutrons preferably include an epithermal neutron flux of at least 1.times.10.sup.13 n s.sup.-1cm.sup.-2. .sup.228Ra can also be bombarded with thermal and/or energetic neutrons to result in a neutron capture reaction to form .sup.229Th. Using .sup.230Th as a target material, .sup.229Th can be formed using neutron, gamma ray, proton or deuteron bombardment.

  9. 48 CFR 229.170-3 - Reports.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Reports. 229.170-3 Section... DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES General 229.170-3 Reports. The contracting officer shall submit a report to the designated Security Assistance Office when a foreign government or entity...

  10. 49 CFR 229.55 - Piston travel.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Piston travel. 229.55 Section 229.55... Piston travel. (a) Brake cylinder piston travel shall be sufficient to provide brake shoe clearance when... piston travel may not exceed 11/2 inches less than the total possible piston travel. The total...

  11. 22 CFR 229.430 - Financial assistance.

    2010-04-01

    ... assist in the administration of scholarships, fellowships, or other forms of financial assistance... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Financial assistance. 229.430 Section 229.430... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex...

  12. 49 CFR 229.64 - Plain bearings.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Plain bearings. 229.64 Section 229.64 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION....64 Plain bearings. A plain bearing box shall contain visible free oil and may not be cracked to...

  13. 49 CFR 229.69 - Side bearings.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Side bearings. 229.69 Section 229.69....69 Side bearings. (a) Friction side bearings with springs designed to carry weight may not have more than 25 percent of the springs in any one nest broken. (b) Friction side bearings may not be run...

  14. 22 CFR 229.540 - Advertising.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Advertising. 229.540 Section 229.540 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in...

  15. 7 CFR 2.29 - Chief Economist.

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Chief Economist. 2.29 Section 2.29 Agriculture Office... Economist. (a) The following delegations of authority are made by the Secretary of Agriculture to the Chief Economist: (1) Related to economic analysis. (i) Coordinate economic analyses of, and review...

  16. Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

    Raeder, S.; Bastin, B.; Block, M.; Creemers, P.; Delahaye, P.; Ferrer, R.; Fléchard, X.; Franchoo, S.; Ghys, L.; Gaffney, L. P.; Granados, C.; Heinke, R.; Hijazi, L.; Huyse, M.; Kron, T.; Kudryavtsev, Yu.; Laatiaoui, M.; Lecesne, N.; Luton, F.; Moore, I. D.; Martinez, Y.; Mogilevskiy, E.; Naubereit, P.; Piot, J.; Rothe, S.; Savajols, H.; Sels, S.; Sonnenschein, V.; Traykov, E.; Van Beveren, C.; Van den Bergh, P.; Van Duppen, P.; Wendt, K.; Zadvornaya, A.

    2016-06-01

    To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility that are needed for the first on-line studies of in-gas-jet laser spectroscopy. Different geometries for the gas outlet and extraction ion guides have been tested for their performance regarding the acceptance of laser ionized species as well as for their differential pumping capacities. The specifications and performance of the temporarily installed high repetition rate laser system, including a narrow bandwidth injection-locked Ti:sapphire laser, are discussed and first preliminary results on neutron-deficient actinium isotopes are presented indicating the high capability of this novel technique.

  17. Dicty_cDB: CFK229 [Dicty_cDB

    Full Text Available CF (Link to library) CFK229 (Link to dictyBase) - - - Contig-U15579-1 CFK229P (Link... to Original site) CFK229F 168 CFK229Z 401 CFK229P 549 - - Show CFK229 Library CF (Link to library) Clone ID CFK229 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U15579-1 Original site URL http://dict...e 2001.11.22 Translated Amino Acid sequence yehlinktq*ksilfiyl**hymni*klenif*KLENIIKKRNKLIFNYKKK--- ---DXICT...ni*klenif*KLENIIKKRNKLIFNYKKK--- ---DXICTXXMXNV*xnlvk*vlxvxqxqxivmimihvxxixviqx*v

  18. 48 CFR 229.170-2 - Policy.

    2010-10-01

    ... DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES General 229.170-2 Policy. (a) By law, bilateral agreements....S. assistance programs shall be exempt from taxation by the foreign government. If taxes or...

  19. 49 CFR 229.121 - Locomotive cab noise.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Locomotive cab noise. 229.121 Section 229.121... § 229.121 Locomotive cab noise. (a) Performance standards for locomotives. (1) When tested for static noise in accordance with paragraph (a)(3) of this section, all locomotives of each design or model...

  20. 48 CFR 252.229-7001 - Tax relief.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Tax relief. 252.229-7001... Clauses 252.229-7001 Tax relief. As prescribed in 229.402-70(a), use the following clause: Tax Relief (JUN 1997) (a) Prices set forth in this contract are exclusive of all taxes and duties from which the...

  1. 12 CFR 229.39 - lnsolvency of bank.

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false lnsolvency of bank. 229.39 Section 229.39 Banks... AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) Collection of Checks § 229.39 lnsolvency of bank..., collecting, depositary, or returning bank that suspends payment, and which is not paid, shall be returned...

  2. 49 CFR 229.43 - Exhaust and battery gases.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Exhaust and battery gases. 229.43 Section 229.43... § 229.43 Exhaust and battery gases. (a) Products of combustion shall be released entirely outside the... conditions. (b) Battery containers shall be vented and batteries kept from gassing excessively....

  3. 49 CFR 229.213 - Locomotive manufacturing information.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Locomotive manufacturing information. 229.213 Section 229.213 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD... Design Requirements § 229.213 Locomotive manufacturing information. (a) Each railroad operating...

  4. 49 CFR 229.105 - Steam generator number.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Steam generator number. 229.105 Section 229.105..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Steam Generators § 229.105 Steam generator number. An identification number shall be marked on the steam...

  5. 7 CFR 58.229 - Filler and packaging equipment.

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Filler and packaging equipment. 58.229 Section 58.229....229 Filler and packaging equipment. All filling and packaging equipment shall be of sanitary... equipment should comply with the 3-A Sanitary Standards for equipment for Packaging Dry Milk and Dry...

  6. 29 CFR 779.229 - Other arrangements.

    2010-07-01

    ..., Franchise and Other Business Arrangements § 779.229 Other arrangements. With respect to those arrangements...” establishment will be considered a part of the same “enterprise.” For example, whether a franchise, lease, or... the enterprise which grants the franchise, right, or concession. (S. Rept. 145, 87th Cong., 1st...

  7. Dicty_cDB: SLJ229 [Dicty_cDB

    Full Text Available ycdb.biol.tsukuba.ac.jp/CSM/SL/SLJ2-B/SLJ229Q.Seq.d/ Representative seq. ID SLJ22...9Z (Link to Original site) Representative DNA sequence >SLJ229 (SLJ229Q) /CSM/SL/SLJ2-B/SLJ229Q.Seq.d/ XXXXX...) Frame A: ---apstmkikiiapperkysvwiggsilaslstfqqmwiskeeydesgpsivhrkcf*t iktsdesashtnkyi*mynnnki*lflmvvdl...: 0.00 m_ : 1.00 44.0 %: cytoplasmic 28.0 %: mitochondrial 20.0 %: nuclear 4.0 %: plasma membrane 4.0 %: peroxisomal >> pre...yq Homology vs CSM-cDNA Score E Sequences producing significant alignments: (bits

  8. Track 8: health and radiological applications. Isotopes and radiation: general. 3. Extraction of 229Th from 233U for Medical Research Applications

    the handling of 233U. After separation, the thorium is transferred to the ORNL Radiochemical Development Laboratory (RDL) for decay and periodic extraction of actinium. The safety basis for the RMAL has recently been upgraded to allow the processing of batches containing up to 500 g of 233U. The 233U from Mound Laboratories was delivered in 20 packages, each containing 232U contamination ranges from 2 to 16 ppm. Individual packages of uranium oxide are transferred from the RDF to the RMAL, the package is opened, and the quantity of uranium is verified. The uranium oxide is dissolved in nitric acid, and the solution is adjusted to 8 M. The solution is passed over a Bio-Rad 1x4 anion exchange column at a rate of ∼5 ml/ min. Thorium and plutonium load on the column; uranium, radium, and actinium pass through. The column is washed with 8 M nitric acid to remove residual uranium. Thorium is then eluted from the resin with 0.1 M nitric acid. This solution, typically containing ∼4 mCi of 229Th, is transferred to the RDL for further purification and is then added to the existing thorium inventory. The uranium and acid wash solutions are combined and evaporated to 3O8 by heating in air to 800 deg. C. The oxide is sampled, weighed, packaged, and returned to storage in the RDF. In fiscal year 2000, the process was set up and two small batches of uranium, with 2 ppm 232U, were processed. Because of the low dose associated with this material and to allow refinements to the process, these initial batches were processed in a glove box. The process performed well, with more than 90% recovery of thorium. Just over 5 mCi of 229Th was added to the inventory. Funding already provided for fiscal year 2001 will allow the extraction of another 30 mCi of 229Th; if additional funding can be identified, a total of nearly 70 mCi can be separated by the end of the fiscal year. With this additional thorium, and with other improvements to the actinium extraction facilities at the RDL, the

  9. 40 CFR 229.2 - Transport of target vessels.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Transport of target vessels. 229.2... PERMITS § 229.2 Transport of target vessels. (a) The U.S. Navy is hereby granted a general permit to transport vessels from the United States or from any other location for the purpose of sinking such...

  10. 40 CFR 229.1 - Burial at sea.

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Burial at sea. 229.1 Section 229.1... Burial at sea. (a) All persons subject to title I of the Act are hereby granted a general permit to... location for the purpose of burial at sea and to bury such remains at sea subject to the...

  11. 49 CFR 190.229 - Criminal penalties generally.

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Criminal penalties generally. 190.229 Section 190... PROGRAMS AND RULEMAKING PROCEDURES Enforcement Criminal Penalties § 190.229 Criminal penalties generally... willfully and knowingly defaces, damages, removes, destroys any pipeline sign, right-of-way marker,...

  12. Dicty_cDB: CHO229 [Dicty_cDB

    Full Text Available CH (Link to library) CHO229 (Link to dictyBase) - - - Contig-U15356-1 | Contig-U15914-1 CHO229P ... a novel protein, a ribosomal protein L29 (RPL29) (HIP , HUMRPL29) pseudogene and a CpG island. 38 0.047 7 ...

  13. 17 CFR 229.801 - Securities Act industry guides.

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Securities Act industry guides. 229.801 Section 229.801 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD INSTRUCTIONS FOR FILING FORMS UNDER SECURITIES ACT OF 1933, SECURITIES EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF...

  14. 17 CFR 229.802 - Exchange Act industry guides.

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Exchange Act industry guides. 229.802 Section 229.802 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION STANDARD INSTRUCTIONS FOR FILING FORMS UNDER SECURITIES ACT OF 1933, SECURITIES EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF...

  15. 49 CFR 229.51 - Aluminum main reservoirs.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Aluminum main reservoirs. 229.51 Section 229.51... Aluminum main reservoirs. (a) Aluminum main reservoirs used on locomotives shall be designed and fabricated as follows: (1) The heads and shell shall be made of Aluminum Association Alloy No. 5083-0,...

  16. 48 CFR 252.229-7002 - Customs exemptions (Germany).

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Customs exemptions... of Provisions And Clauses 252.229-7002 Customs exemptions (Germany). As prescribed in 229.402-70(b), use the following clause: Customs Exemptions (Germany) (JUN 1997) Imported products required for...

  17. 48 CFR 229.402-70 - Additional clauses.

    2010-10-01

    ... performance will be in Spain. (f) Use the clause at 252.229-7006, Value Added Tax Exclusion (United Kingdom.... (i) Use the clause at 252.229-7009, Relief from Customs Duty and Value Added Tax on Fuel (Passenger... SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES Contract Clauses...

  18. 49 CFR 229.139 - Sanitation, servicing requirements.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Sanitation, servicing requirements. 229.139... Cab Equipment § 229.139 Sanitation, servicing requirements. (a) The sanitation compartment of each... present that prevents waste from evacuating the bowl. (c) The sanitation compartment of each...

  19. 49 CFR 229.137 - Sanitation, general requirements.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Sanitation, general requirements. 229.137 Section... Cab Equipment § 229.137 Sanitation, general requirements. (a) Sanitation compartment. Except as provided in paragraph (b) of this section, all lead locomotives in use shall be equipped with a...

  20. 49 CFR 229.33 - Out-of-use credit.

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Out-of-use credit. 229.33 Section 229.33... credit. When a locomotive is out of use for 30 or more consecutive days or is out of use when it is due... credit....

  1. New method for large scale production of medically applicable Actinium-225 and Radium-223

    Alpha-emitters (211At, 212Bi, 213Bi, 223Ra, 225Ac) are promising for targeted radiotherapy of cancer. Only two alpha decays near a cell membrane result in 50% death of cancer cell and only a single decay inside the cell is required for this. 225Ac may be used either directly or as a mother radionuclide in 213Bi isotope generator. Production of 225Ac is provided by three main suppliers - Institute for Transuranium Elements in Germany, Oak Ridge National Laboratory in USA and Institute of Physics and Power Engineering in Obninsk, Russia. The current worldwide production of 225Ac is approximately 1.7 Ci per year that corresponds to only 100-200 patients that could be treated annually. The common approach for 225Ac production is separation from mother 229Th or irradiation of 226Ra with protons in a cyclotron. Both the methods have some practical limitations to be applied routinely. 225Ac can be also produced by irradiation of natural thorium with medium energy protons . Cumulative cross sections of 225Ac, 227Ac, 227Th, 228Th formations have been obtained recently. Thorium targets (1-9 g) were irradiated by 114-91 MeV proton beam (1-50 μA) at INR linear accelerator. After dissolution in 8 M HNO3 + 0.004 M HF thorium was removed by double LLX by HDEHP in toluene (1:1). Ac and REE were pre-concentrated and separated from Ra and most fission products by DGA-Resin (Triskem). After washing out by 0.01 M HNO3 Ac was separated from REE by TRU Resin (Triskem) in 3 M HNO3 media. About 6 mCi 225Ac were separated in hot cell with chemical yield 85%. The method may be upscaled for production of Ci amounts of the radionuclide. The main impurity is 227Ac (0.1% at the EOB) but it does not hinder 225Ac from being used for medical 225Ac/213Bi generators. (author)

  2. Groundwater seepage from the Ranger uranium mine tailings dam: radioisotopes of radium, thorium and actinium. Supervising Scientist report 106

    Monitoring of bores near the Ranger uranium mine tailings dam has revealed deterioration in water quality in several bores since 1983. In a group of bores to the north of the dam, increases have been observed of up to 500 times for sulphate concentrations and of up to 5 times for 226Ra concentrations. Results are presented here of measurements of members of the uranium, thorium and actinium decay series in borewater samples collected between 1985 and 1993. In particular, measurements of all four naturally-occurring radium isotopes have been used in an investigation of the mechanism of radium concentration changes. For the most seepage-affected bores the major findings of the study include: 228Ra/226Ra 223Ra /226Ra and 224Ra/228Ra ratios all increased over the course of the study; barium concentrations show high seasonal variability, being lower in November than May, but strontium concentrations show a steady increase with time. Calculations show that the groundwater is probably saturated with respect to barite but not with respect to celestite or anglesite; sulphide concentrations are low in comparison with sulphate, and are higher in November than in May; and 227Ac concentrations have increased with time, but do not account for the high 223Ra/226Ra ratios. It is concluded on the basis of these observations that increases in Ra isotope concentrations observed in a number of seepage-affected bores arise from increases in salinity leading to desorption of radium from adsorption sites in the vicinity of the bore rather by direct transport of radium from the tailings. Increased salinity is also causing the observed increases in 227Ac and strontium concentrations, while formation of a barite solid phase in the groundwater is causing the removal of some radium from solution. This is the cause of the increasing radium isotope ratios noted above

  3. 48 CFR 252.229-7008 - Relief from import duty (United Kingdom).

    2010-10-01

    ... (United Kingdom). 252.229-7008 Section 252.229-7008 Federal Acquisition Regulations System DEFENSE... CLAUSES Text of Provisions And Clauses 252.229-7008 Relief from import duty (United Kingdom). As prescribed in 229.402-70(h), use the following clause: Relief from Import Duty (United Kingdom) (JUN...

  4. 5 CFR 532.229 - Local wage survey committee.

    2010-01-01

    ... committee members, consideration shall be given to the requirement in the prevailing rate law for labor and... PREVAILING RATE SYSTEMS Prevailing Rate Determinations § 532.229 Local wage survey committee. (a)(1) A...

  5. 49 CFR 229.57 - Foundation brake gear.

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Brake System § 229.57... to the wheel to prevent localized thermal stress in the edge of the rim or the flange....

  6. Dicty_cDB: SFF229 [Dicty_cDB

    Full Text Available SF (Link to library) SFF229 (Link to dictyBase) - - - Contig-U16287-1 SFF229Z (Link to Original ... equence. 42 4e-05 2 CF514038 |CF514038.1 CAbud0007_IVF _G07 Vitis vinifera cv. cabernet sauvignon (Clone 8 ... ) Bud - CABUD Vitis vinifera cDNA clone CAbud0007_IVF _G07 5', mRNA sequence. 60 4e-05 1 dna update 2003. ...

  7. 17 CFR 229.512 - (Item 512) Undertakings.

    2010-04-01

    ... statement to include any financial statements required by “Item 8.A. of Form 20-F (17 CFR 249.220f)” at the... with Item 1100(c)(1) of Regulation AB (17 CFR 229.1100(c)(1)) shall be deemed to be a new registration... CFR 229.1105), information provided in response to that Item pursuant to Rule 312 of Regulation...

  8. Purify of MJ229 Chymosin%MJ229凝乳酶的纯化

    程巧玲

    2011-01-01

    Chymosin is one of the key enzymes during the production of cheese. With the development of cheese industry, chymosin made by traditional method is not sufficient for its production, so the researchers are looking for the new sources of cbymosin. MJ229 can produce chymosin, that was isolated from glutinous rice wine which was a traditional food in south of China. The enzyme liquor of MJ229 solid - state fermentation was concentrated through hollow fiber ultrafiltration membrane with aperture 60kDa and 6kDa during this experiment. The volume was concentrated 15. 6 times.The enzyme was purified 2. 15 times and the yield radio was 82. 6%. The concentration was purified by Sephadex G 100. The milk -clotting activity was 2200. 0U/mg after purification and it was confirmed by SDS - PAGE pattern that showed the chymosin was nearly purified with a molecular mass of 35.0kDa.%凝乳酶是干酪生产中的关键性酶,随着世界干酪工业的不断发展,传统来源的凝乳酶已远不能满足生产需要,各国研究者不断地寻找新的来源.MJ229是从我国传统食品江米酒酒醪中筛选得到的一株凝乳酶高产菌株.本实验利用截留分子量为60kDa和6kDa的中空纤维超滤膜对MJ229固态发酵物中凝乳酶的浸提液进行浓缩,浸提液体积被浓缩了15.6倍,凝乳酶纯化倍数达2.15倍,活力回收率为82.6%.进一步通过SephadexG-100纯化,得到电泳纯的凝乳酶,活力为2200.0U/mg,同时测得其分子量为35kDa.

  9. The nuclear structure of 229Pa from the 231Pa(p,t)229Pa and 230Th(p,2nγ)229Pa reactions

    The level structure of the 229Pa nucleus has been investigated by means of the 231Pa(p,t)229Pa and 230Th(p,2nγ)229Pa reactions. Triton angular-distribution measurements were subjected to a CCBA analysis and combined with the results of in-beam conversion electron and γ-ray spectroscopy to establish a level scheme. Two low-lying bands of opposite parity were observed up to spins (23/2)- and (17/2)+, respectively. Rotational bands built on some 0+ excitations of the even-even core can be assigned. The lowest states of three further low-lying bands are observed. The level scheme is interpreted in terms of an octupole-deformed core with an unpaired proton. From the E1/E2 branching ratio the electric dipole moment can be deduced vertical stroke D0vertical stroke =(0.09 ±0.04) e .fm. ((orig.))

  10. Electron capture decay of 58-min U-229(92) and levels in Pa-229(91)

    Ahmad, I.; Chasman, R. R.; Greene, J. P.; Kondev, F. G.; Zhu, S.

    2015-08-17

    Electron capture decay of U-229 is investigated by measuring the gamma-ray and conversion electron spectra of mass-separated and unseparated U-229 sources with high-resolution germanium and silicon detectors, respectively. Gamma-gamma coincidence measurements are also performed using germanium detectors. These studies provide level energies and level ordering in Pa-229. Single-particle assignments are given to these levels which are in agreement with the systematics in this region and also with theory. In a previous study, we report the observation of a 5/2(+/-) parity doublet in the Pa-229 ground state, which is a signature of octupole deformation. The present analysis of the data still shows a splitting of 60 +/- 50 eV, but with this large uncertainty the existence of the doublet is not certain.

  11. Determination of the ^229Th isomer half-life

    Burke, Jason; Beck, Bret; Becker, John; Haydell, Michael; Norman, Rick; Scielzo, Nicholas; Sheets, Steven; Swanberg, Erik

    2009-10-01

    Recently there has been renewed interest in studying the nuclear properties of the ^229Th isomer. ^229Th has the lowest known isomer at 7.6 eV [1]. Direct laser manipulation of the ground and first excited states could lead to the realization of the world's first nuclear clock. To understand the linewidth of the isomeric state we are conducting experiments to directly observe the half-life of the isomer decay. We use a novel ``hot-atom'' technique in which we catch the recoiling ^229Th nuclei following the alpha decay of ^233U -> ^229Th + α. On average 2% of the ^229Th populate the isomeric 3/2+ state compared to the 5/2+ ground state. Recoils are collected on various catcher plate materials, rotated in vacuum in front of an einzel lense and multi-channel plate detector. The internal conversion electrons are counted as a function of time to determine the half-life. Varying the catcher plate material we can investigate the effect that the materials have on the half-life. Determination of the half-life we will provide valuable guidance to Th trapping research [2]. 1) Beck et al., PRL 98, 142501 (2007) 2) Campbell et al., PRL 102, 233004 (2009) This work performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  12. 17 CFR 229.1112 - (Item 1112) Significant obligors of pool assets.

    2010-04-01

    ... obligors of pool assets. 229.1112 Section 229.1112 Commodity and Securities Exchanges SECURITIES AND... EXCHANGE ACT OF 1934 AND ENERGY POLICY AND CONSERVATION ACT OF 1975-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1112 (Item 1112) Significant obligors of pool assets. (a) Descriptive...

  13. 33 CFR 110.229 - Straits of Juan de Fuca, Wash.

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Straits of Juan de Fuca, Wash. 110.229 Section 110.229 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Anchorage Grounds § 110.229 Straits of Juan de Fuca, Wash. (a)...

  14. 49 CFR 173.229 - Chloric acid solution or chlorine dioxide hydrate, frozen.

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Chloric acid solution or chlorine dioxide hydrate, frozen. 173.229 Section 173.229 Transportation Other Regulations Relating to Transportation PIPELINE AND... Than Class 1 and Class 7 § 173.229 Chloric acid solution or chlorine dioxide hydrate, frozen. When...

  15. 17 CFR 229.308 - (Item 308) Internal control over financial reporting.

    2010-04-01

    ... over financial reporting. 229.308 Section 229.308 Commodity and Securities Exchanges SECURITIES AND... § 229.308 (Item 308) Internal control over financial reporting. (a) Management's annual report on internal control over financial reporting. Provide a report of management on the registrant's...

  16. 17 CFR 229.308T - (Item 308T) Internal control over financial reporting.

    2010-04-01

    ... over financial reporting. 229.308T Section 229.308T Commodity and Securities Exchanges SECURITIES AND... § 229.308T (Item 308T) Internal control over financial reporting. Note to Item 308T: This is a special... internal control over financial reporting. Provide a report of management on the registrant's...

  17. 48 CFR 252.229-7010 - Relief from customs duty on fuel (United Kingdom).

    2010-10-01

    ... on fuel (United Kingdom). 252.229-7010 Section 252.229-7010 Federal Acquisition Regulations System... (United Kingdom). As prescribed in 229.402-70(j), use the following clause: Relief from Customs Duty on Fuel (United Kingdom) (JUN 1997) (a) Pursuant to an agreement between the United States Government...

  18. 50 CFR 229.33 - Harbor Porpoise Take Reduction Plan Regulations-New England.

    2010-10-01

    ... Regulations-New England. 229.33 Section 229.33 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE... Emergency Regulations § 229.33 Harbor Porpoise Take Reduction Plan Regulations—New England. (a) Restrictions... metric tons of landings. (5) Southern New England Management Area—(i) Area restrictions. From December...

  19. 48 CFR 229.170 - Reporting of foreign taxation on U.S. assistance programs.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Reporting of foreign taxation on U.S. assistance programs. 229.170 Section 229.170 Federal Acquisition Regulations System... General 229.170 Reporting of foreign taxation on U.S. assistance programs....

  20. 17 CFR 229.1103 - (Item 1103) Transaction summary and risk factors.

    2010-04-01

    ... summary and risk factors. 229.1103 Section 229.1103 Commodity and Securities Exchanges SECURITIES AND... (Regulation AB) § 229.1103 (Item 1103) Transaction summary and risk factors. (a) Prospectus summary. In... be assigned. (b) Risk factors. In providing the information required by Item 503(c) of Regulation...

  1. 36 CFR 223.229 - Contents of prospectus.

    2010-07-01

    ... AND DISPOSAL OF NATIONAL FOREST SYSTEM TIMBER Special Forest Products Advertisement and Bids § 223.229...: (a) The minimum acceptable value or unit price for a product and the amount or rate of any deposits required in addition to the unit price of a product; (b) The amount of the bid guarantee that...

  2. 17 CFR 229.406 - (Item 406) Code of ethics.

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 406) Code of ethics. 229... 406) Code of ethics. (a) Disclose whether the registrant has adopted a code of ethics that applies to... code of ethics, explain why it has not done so. (b) For purposes of this Item 406, the term code...

  3. 48 CFR 229.101 - Resolving tax problems.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Resolving tax problems..., DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS TAXES General 229.101 Resolving tax problems. (a... Counsels of the Navy and Air Force, and for the Army, the Chief, Contract Law Division, Office of the...

  4. 50 CFR 229.5 - Requirements for Category III fisheries.

    2010-10-01

    ... Certificate. (b) Reporting. Vessel owners engaged in a Category III fishery must comply with the reporting... fishery must comply with the observer requirements specified under § 229.7(d). (e) Deterrence. When necessary to deter a marine mammal from damaging fishing gear, catch, or other private property, or...

  5. 49 CFR 229.75 - Wheels and tire defects.

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Suspension System § 229... in width. (c) A broken rim, if the tread, measured from the flange at a point five-eighths inch above... crack or break in the flange, tread, rim, plate, or hub. (l) A loose wheel or tire. (m) Fusion...

  6. 32 CFR 229.4 - Prohibited acts and criminal penalties.

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Prohibited acts and criminal penalties. 229.4... and criminal penalties. (a) Under section 6(a) of the Act, no person may excavate, remove, damage, or..., regulation, ordinance, or permit in effect under any other provision of Federal law. (c) Under section (d)...

  7. 22 CFR 229.130 - Effect of employment opportunities.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Effect of employment opportunities. 229.130... Effect of employment opportunities. The obligation to comply with these Title IX regulations is not obviated or alleviated because employment opportunities in any occupation or profession are or may be...

  8. 50 CFR 229.35 - Bottlenose Dolphin Take Reduction Plan.

    2010-10-01

    ... National Oceanic and Atmospheric Administration (Coast Charts 1:80,000 scale), and as described in 33 CFR... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Bottlenose Dolphin Take Reduction Plan... § 229.35 Bottlenose Dolphin Take Reduction Plan. (a) Purpose and scope. The purpose of this section...

  9. 22 CFR 229.400 - Education programs or activities.

    2010-04-01

    ... SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 229.400 Education programs or activities... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Education programs or activities....

  10. 40 CFR 180.229 - Fluometuron; tolerances for residues.

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Fluometuron; tolerances for residues...) PESTICIDE PROGRAMS TOLERANCES AND EXEMPTIONS FOR PESTICIDE CHEMICAL RESIDUES IN FOOD Specific Tolerances § 180.229 Fluometuron; tolerances for residues. (a) General. (1) Tolerances are established for...

  11. Dicty_cDB: CHS229 [Dicty_cDB

    Full Text Available CH (Link to library) CHS229 (Link to dictyBase) - - - Contig-U15036-1 - (Link to Original site) ... ents: (bits) Value AM050060_1( AM050060 |pid:none) Azospirillum ... brasilense partial pu... 153 5e-38 CP000943_2544( ...

  12. Direct detection of the 229Th nuclear clock transition

    von der Wense, Lars; Seiferle, Benedict; Laatiaoui, Mustapha; Neumayr, Jürgen B.; Maier, Hans-Jörg; Wirth, Hans-Friedrich; Mokry, Christoph; Runke, Jörg; Eberhardt, Klaus; Düllmann, Christoph E.; Trautmann, Norbert G.; Thirolf, Peter G.

    2016-05-01

    Today’s most precise time and frequency measurements are performed with optical atomic clocks. However, it has been proposed that they could potentially be outperformed by a nuclear clock, which employs a nuclear transition instead of an atomic shell transition. There is only one known nuclear state that could serve as a nuclear clock using currently available technology, namely, the isomeric first excited state of 229Th (denoted 229mTh). Here we report the direct detection of this nuclear state, which is further confirmation of the existence of the isomer and lays the foundation for precise studies of its decay parameters. On the basis of this direct detection, the isomeric energy is constrained to between 6.3 and 18.3 electronvolts, and the half-life is found to be longer than 60 seconds for 229mTh2+. More precise determinations appear to be within reach, and would pave the way to the development of a nuclear frequency standard.

  13. CW, single-frequency 229nm laser source for Cd-cooling by harmonic conversion

    Kaneda, Yushi; Yarborough, J. M.; Merzlyak, Yevgeny

    2015-02-01

    More than 200mW of CW 229nm for Cd atom cooling application was generated by the 4th harmonic of a single frequency optically pumped semiconductor laser using a 10-mm long, Brewster-cut BBO crystal in an external cavity. With 650mW of 458nm input, 216mW of 229nm power was observed. Conversion efficiency from 458nm to 229nm was more than 33%.

  14. Dicty_cDB: SLG229 [Dicty_cDB

    Full Text Available Dictyostelium discoideum slug cDNA, clone SLG229. 313 e-120 2 ( AU052966 ) Dictyostelium discoideum slug cDN...A, clone SLF396. 313 e-107 4 ( AU053262 ) Dictyostelium discoideum slug cDNA, clone SLI263. 313 e-107 4 ( AU...034176 ) Dictyostelium discoideum slug cDNA, clone SLC144. 313 e-107 4 ( AU033450 ) Dictyostelium discoideum slug... cDNA, clone SLA841. 313 e-107 4 ( AU033594 ) Dictyostelium discoideum slug ...cDNA, clone SLB210. 313 e-107 4 ( AU039267 ) Dictyostelium discoideum slug cDNA, clone SLH314. 313 e-107 4 (

  15. Experiments towards optical nuclear spectroscopy with thorium-229

    Zimmermann, Kai

    2010-07-01

    The discovery of the low-lying isomeric nuclear state of {sup 229}Th at 7.6{+-} 0.5 eV above the ground state opened a new field of research as a bridge between nuclear and atomic physics. Since indirect {gamma}-spectroscopy techniques were applied for detection of the isomeric state, the direct observation of the nuclear photon emission is still pending. This thesis describes the steps towards the direct observation of {sup 229m}Th. The first conducted experiments examine measurements of atoms in the isomeric state {sup 229m}Th being produced in the {alpha}-decay of {sup 229}U. Recoil atoms were ejected from a thin {sup 233}U source, accumulated in an absorber and analyzed for the emission of UV and VUV photons. No evidence for the decay of the isomeric state was found. The observed background signal has been identified as Cherenkov radiation. The main part of this theses describes the setup of a linear Paul trap with a high storage capacity that has been built and loaded with more than 8 . 10{sup 4} Th{sup +} ions using laser ablation loading. Laser ablation of thorium ions has been shown using a pulsed nitrogen laser at a wavelength of 337 nm, a pulse energy of 170 {mu}J and a pulse width of 4 ns in a time-of-flight mass spectrometer. The ratio of ablated Th{sup +} to Th{sup 2+} ions was investigated in relation to the laser pulse power. Th{sup +} ablation from a dried {sup 232}Th(NO{sub 3}){sub 4} solution has been shown from multiple substrate surfaces as a preparation for the loading of the more radioactive {sup 229}Th from a minimum amount of substance. The trapped ions were characterized by ion ejection and counting, electronic detection and optical detection methods. We investigated the loading conditions, trap potentials, the stored ion numbers, buffer gas cooling, the laser ablation velocity distribution, and the phase dependence of the radiofrequency field for the ion loading. Gas discharges were observed between the electrodes in the plasma created by

  16. 42 CFR 414.229 - Other durable medical equipment-capped rental items.

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Other durable medical equipment-capped rental items. 414.229 Section 414.229 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM PAYMENT FOR PART B MEDICAL AND OTHER HEALTH...

  17. 20 CFR 229.22 - Beginning date of increase under overall minimum.

    2010-04-01

    ... social security earnings; or (4) The month the employee attains retirement age, if a DIB O/M was paid in the previous month. A DIB O/M is changed to an age O/M in the month the employee attains retirement... minimum. 229.22 Section 229.22 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER...

  18. 20 CFR 229.40 - When an annuity increase under the overall minimum ends.

    2010-04-01

    ... on age rather than disability, and the employee is under retirement age, the increase ends with the... the employee attains retirement age (the DIB O/M is changed to an age O/M); or (3) The second month... minimum ends. 229.40 Section 229.40 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER...

  19. 20 CFR 229.10 - What the social security overall minimum guarantee is.

    2010-04-01

    ... payable before the employee attains retirement age. An overall minimum may also be payable before age 62... guarantee is. 229.10 Section 229.10 Employees' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Social Security Overall Minimum...

  20. 40 CFR 52.229 - Control strategy and regulations: Photochemical oxidants (hydrocarbons), Metropolitan Los Angeles...

    2010-07-01

    ... 40 CFR 52.223 is retained. (ii) Rule 1115, Automotive Coatings, adopted on March 16, 1984 by the...: Photochemical oxidants (hydrocarbons), Metropolitan Los Angeles Intrastate Region. 52.229 Section 52.229... oxidants (hydrocarbons), Metropolitan Los Angeles Intrastate Region. (a) (b) The following rules...

  1. 17 CFR 229.1204 - (Item 1204) Oil and gas production, production prices and production costs.

    2010-04-01

    ... conversion to synthetic oil or gas, the product's production, transfer prices, and production costs should be... production, production prices and production costs. 229.1204 Section 229.1204 Commodity and Securities... production, production prices and production costs. (a) For each of the last three fiscal years...

  2. 40 CFR 264.229 - Special requirements for ignitable or reactive waste.

    2010-07-01

    ... reactive waste. 264.229 Section 264.229 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR OWNERS AND OPERATORS OF HAZARDOUS WASTE TREATMENT, STORAGE... impoundment satisfy all applicable requirements of 40 CFR part 268, and: (a) The waste is treated,...

  3. 49 CFR Appendix D to Part 229 - Criteria for Certification of Crashworthy Event Recorder Memory Module

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Criteria for Certification of Crashworthy Event Recorder Memory Module D Appendix D to Part 229 Transportation Other Regulations Relating to Transportation... Memory Module Section 229.135(b) requires that certain locomotives be equipped with an event...

  4. 50 CFR 229.12 - Consultation with the Secretary of the Interior.

    2010-10-01

    ... Interior. 229.12 Section 229.12 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC... Secretary of the Interior. The Assistant Administrator will consult with the Secretary of the Interior prior... population stocks of marine mammals for which the Secretary of the Interior is responsible under the Act....

  5. 50 CFR 229.7 - Monitoring of incidental mortalities and serious injuries.

    2010-10-01

    ... serious injuries. 229.7 Section 229.7 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL... mortalities and serious injuries. (a) Purpose. The Assistant Administrator will establish a program to monitor incidental mortality and serious injury of marine mammals during the course of commercial fishing...

  6. 48 CFR 252.229-7006 - Value added tax exclusion (United Kingdom).

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Value added tax exclusion... CLAUSES Text of Provisions And Clauses 252.229-7006 Value added tax exclusion (United Kingdom). As prescribed in 229.402-70(f), use the following clause: Value Added Tax Exclusion (United Kingdom) (JUN...

  7. 48 CFR 252.229-7000 - Invoices exclusive of taxes or duties.

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Invoices exclusive of... CLAUSES Text of Provisions And Clauses 252.229-7000 Invoices exclusive of taxes or duties. As prescribed in 229.402-1, use the following clause: Invoices Exclusive of Taxes or Duties (JUN 1997)...

  8. 42 CFR 435.229 - Optional targeted low-income children.

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Optional targeted low-income children. 435.229... Coverage of Families and Children § 435.229 Optional targeted low-income children. The agency may provide Medicaid to— (a) All individuals under age 19 who are optional targeted low-income children as defined...

  9. 42 CFR 436.229 - Optional targeted low-income children.

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Optional targeted low-income children. 436.229..., and Disabled Individuals, Including Pregnant Women § 436.229 Optional targeted low-income children. The agency may provide Medicaid to— (a) All individuals under age 19 who are optional targeted...

  10. 46 CFR 10.229 - Issuance of duplicate merchant mariner credentials.

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Issuance of duplicate merchant mariner credentials. 10.229 Section 10.229 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN MERCHANT MARINER CREDENTIAL General Requirements for All Merchant Mariner Credentials §...

  11. Separation and estimation of 229Th and 233U by alpha and gamma ray spectrometric technique

    The individual estimation of 233U and 229Th in a plancheted source made out of liquid sample were done by using an alpha and γ-ray spectrometric techniques. Estimation of 229Th in the plancheted source was done by γ-ray spectrometry and 233U by alpha spectrometry after subtracting the estimated amount of 229Th. In spite of the same alpha energy of 4.8 MeV, the individual estimation of 233U and 229Th based on present technique is superior to conventional techniques and important in the 232Th-233U fuel reprocessing cycle of AHWR and ADSs. The activity of 229Th was also radiochemically separated from its parent activity of 233U by using an ion exchange resin and the purity was checked by the above mentioned technique. (author)

  12. 17 CFR 229.1114 - (Item 1114) Credit enhancement and other support, except for certain derivatives instruments.

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1114) Credit enhancement and other support, except for certain derivatives instruments. 229.1114 Section 229.1114 Commodity and...-REGULATION S-K Asset-Backed Securities (Regulation AB) § 229.1114 (Item 1114) Credit enhancement and...

  13. 48 CFR 252.229-7009 - Relief from customs duty and value added tax on fuel (passenger vehicles) (United Kingdom).

    2010-10-01

    ... and value added tax on fuel (passenger vehicles) (United Kingdom). 252.229-7009 Section 252.229-7009... Relief from customs duty and value added tax on fuel (passenger vehicles) (United Kingdom). As prescribed in 229.402-70(i), use the following clause: Relief from Customs Duty and Value Added Tax on...

  14. Performance of a 229Thorium solid-state nuclear clock

    The 7.8 eV nuclear isomer transition in 229thorium has been suggested as a clock transition in a new type of optical frequency standard. Here we discuss the construction of a ‘solid-state nuclear clock’ from thorium nuclei implanted into single crystals transparent in the vacuum ultraviolet range. We investigate crystal-induced line shifts and broadening effects for the specific system of calcium fluoride. At liquid nitrogen temperatures, the clock performance will be limited by decoherence due to magnetic coupling of the thorium nuclei to neighboring nuclear moments, ruling out the commonly used Rabi or Ramsey interrogation schemes. We propose clock stabilization based on a fluorescence spectroscopy method and present optimized operation parameters. Taking advantage of the large number of quantum oscillators under continuous interrogation, a fractional instability level of 10−19 might be reached within the solid-state approach. (paper)

  15. Human Coronavirus 229E Binds to CD13 in Rafts and Enters the Cell through Caveolae

    Nomura, Ryuji; Kiyota, Asuka; Suzaki, Etsuko; Kataoka, Katsuko; Ohe, Yoshihide; Miyamoto, Kaoru; Senda, Takao; Fujimoto, Toyoshi

    2004-01-01

    CD13, a receptor for human coronavirus 229E (HCoV-229E), was identified as a major component of the Triton X-100-resistant membrane microdomain in human fibroblasts. The incubation of living fibroblasts with an anti-CD13 antibody on ice gave punctate labeling that was evenly distributed on the cell surface, but raising the temperature to 37°C before fixation caused aggregation of the labeling. The aggregated labeling of CD13 colocalized with caveolin-1 in most cells. The HCoV-229E virus parti...

  16. Does a 5/2+-5/2- ground-state parity doublet exist in 229Pa?

    The 1/2[530] decoupled band in 229Pa has been identified up to the 19/2- level in (p,t) and (p,2nγ) experiments. It is found that the 3/2- band head has an excitation energy of 19(10) keV, and can thus not be identified with a 123 keV level observed in the 229U electron capture decay. This removes the evidence presented earlier for a spin-parity assignment of 5/2+-5/2- to a proposed nearly degenerate ground-state doublet in 229Pa

  17. Continuous-wave, single-frequency 229 nm laser source for laser cooling of cadmium atoms

    Kaneda, Yushi; Yarborough, J. M.; Merzlyak, Yevgeny; Yamaguchi, Atsushi; Hayashida, Keitaro; Ohmae, Noriaki; Katori, Hidetoshi

    2016-01-01

    Continuous-wave output at 229 nm for the application of laser cooling of Cd atoms was generated by the 4th harmonic using two successive second harmonic generation stages. Employing a single-frequency optically pumped semiconductor laser as a fundamental source, 0.56 W of output at 229 nm was observed with a 10-mm long, Brewster-cut BBO crystal in an external cavity with 1.62 W of 458 nm input. Conversion efficiency from 458 nm to 229 nm was more than 34%. By applying a tapered amplifier as a...

  18. The extraction of 229Th3+ from a buffer-gas stopping cell

    Wense, L. v. d.; Seiferle, B.; Laatiaoui, M.; Thirolf, P. G.

    2016-06-01

    In the whole landscape of atomic nuclei, 229Th is currently the only known nucleus which could allow for the development of a nuclear-based frequency standard, as it possesses an isomeric state of just 7.6 eV energy above the ground state. The 3+ charge state is of special importance in this context, as Th3+ allows for a simple laser-cooling scheme. Here we emphasize the direct extraction of triply-charged 229Th from a buffer-gas stopping cell. This finding will not only simplify any future approach of 229Th ion cooling, but is also used for thorium-beam purification and in this way provides a powerful tool for the direct identification of the 229Th isomer to ground state nuclear transition.

  19. 229 people, 15,000 body parts: pathologists help solve Swissair 111's grisly puzzles.

    Robb, N.

    1999-01-01

    Only 1 of the 229 passengers and crew members killed when Swissair Flight 111 crashed off Nova Scotia in September was visually identifiable. Identifying everyone else on board involved medical and dental detective work of the first order.

  20. Human Coronavirus 229E Infects Polarized Airway Epithelia from the Apical Surface

    Wang, Guoshun; Deering, Camille; Macke, Michael; Shao, Jianqiang; Burns, Royce; Blau, Dianna M.; Holmes, Kathryn V.; Davidson, Beverly L.; Perlman, Stanley; McCray, Paul B.

    2000-01-01

    Gene transfer to differentiated airway epithelia with existing viral vectors is very inefficient when they are applied to the apical surface. This largely reflects the polarized distribution of receptors on the basolateral surface. To identify new receptor-ligand interactions that might be used to redirect vectors to the apical surface, we investigated the process of infection of airway epithelial cells by human coronavirus 229E (HCoV-229E), a common cause of respiratory tract infections. Usi...

  1. Continuous-wave, single-frequency 229 nm laser source for laser cooling of cadmium atoms

    Kaneda, Yushi; Merzlyak, Yevgeny; Yamaguchi, Atsushi; Hayashida, Keitaro; Ohmae, Noriaki; Katori, Hidetoshi

    2016-01-01

    Continuous-wave output at 229 nm for the application of laser cooling of Cd atoms was generated by the 4th harmonic using two successive second harmonic generation stages. Employing a single-frequency optically pumped semiconductor laser as a fundamental source, 0.56 W of output at 229 nm was observed with a 10-mm long, Brewster-cut BBO crystal in an external cavity with 1.62 W of 458 nm input. Conversion efficiency from 458 nm to 229 nm was more than 34%. By applying a tapered amplifier as a fundamental source, we demonstrated magneto-optical trapping of all stable Cd isotopes including isotopes $^{111}$Cd and $^{113}$Cd, which are applicable to optical lattice clocks.

  2. 17 CFR 229.1201 - (Item 1201) General instructions to oil and gas industry-specific disclosures.

    2010-04-01

    ... instructions to oil and gas industry-specific disclosures. 229.1201 Section 229.1201 Commodity and Securities... instructions to oil and gas industry-specific disclosures. (a) If oil and gas producing activities are material... required tables. (c) The definitions in Rule 4-10(a) of Regulation S-X (17 CFR 210.4-10(a)) shall apply...

  3. 17 CFR 229.304 - (Item 304) Changes in and disagreements with accountants on accounting and financial disclosure.

    2010-04-01

    ... disagreements with accountants on accounting and financial disclosure. 229.304 Section 229.304 Commodity and... accounting and financial disclosure. (a)(1) If during the registrant's two most recent fiscal years or any... any matter of accounting principles or practices, financial statement disclosure, or auditing scope...

  4. 20 CFR 229.50 - Age reduction in employee or spouse benefit.

    2010-04-01

    ... RETIREMENT ACT SOCIAL SECURITY OVERALL MINIMUM GUARANTEE Computation of the Overall Minimum Rate § 229.50 Age... benefit is reduced for each month the employee is under retirement age on the date the employee becomes... under retirement age on the date the spouse is eligible for an increase under the overall minimum...

  5. 40 CFR 86.229-94 - Road load force, test weight, and inertia weight class determination.

    2010-07-01

    ... 40 Protection of Environment 18 2010-07-01 2010-07-01 false Road load force, test weight, and... § 86.229-94 Road load force, test weight, and inertia weight class determination. (a) Flywheels... adjusted to simulate the operation of a vehicle on the road at 20 °F (−7 °C). Such adjustment may be...

  6. 14 CFR 417.229 - Far-field overpressure blast effects analysis.

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Far-field overpressure blast effects... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LAUNCH SAFETY Flight Safety Analysis § 417.229 Far-field... criteria that protect the public from any hazard associated with far field blast overpressure effects...

  7. 17 CFR 229.912 - (Item 912) Source and amount of funds and transactional expenses.

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 912) Source and amount... Transactions § 229.912 (Item 912) Source and amount of funds and transactional expenses. (a) State the source... sources of capital to finance such amount. (c) If all or any part of the consideration to be used by...

  8. 17 CFR 229.1003 - (Item 1003) Identity and background of filing person.

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false (Item 1003) Identity and... (Regulation M-A) § 229.1003 (Item 1003) Identity and background of filing person. (a) Name and address. State...; (4) A statement whether or not the person was a party to any judicial or administrative...

  9. 48 CFR 252.229-7011 - Reporting of Foreign Taxes-U.S. Assistance Programs.

    2010-10-01

    ... all value added taxes and customs duties imposed by the recipient country. This exemption is in... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Reporting of Foreign Taxes... AND CONTRACT CLAUSES Text of Provisions And Clauses 252.229-7011 Reporting of Foreign...

  10. Measuring the Th-229 nuclear isomer transition with U-233 doped crystals

    Stellmer, Simon; Kazakov, Georgy; Sterba, Johannes; Schumm, Thorsten

    2015-01-01

    We propose a simple approach to measure the energy of the few-eV isomeric state in Th-229. To this end, U-229 nuclei are doped into VUV-transparent crystals, where they undergo alpha decay into Th-229, and, with a probability of 2%, populate the isomeric state. These Th-229m nuclei may decay into the nuclear ground state under emission of the sought-after VUV gamma, whose wavelength can be determined with a spectrometer. Based on measurements of the optical transmission of U:CaF2 crystals in the VUV range, we expect a signal at least 2 orders of magnitude larger compared to current schemes using surface-implantation of recoil nuclei. The signal background is dominated by Cherenkov radiation induced by beta decays of the thorium decay chain. We estimate that, even if the isomer undergoes radiative de-excitation with a probability of only 0.1%, the VUV gamma can be detected within a reasonable measurement time.

  11. 22 CFR 229.425 - Counseling and use of appraisal and counseling materials.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Counseling and use of appraisal and counseling... Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 229.425 Counseling and use of appraisal and counseling materials. (a) Counseling. A recipient shall not discriminate against any person...

  12. 77 FR 3255 - Notice of 229 Boundary Revision at the Paducah Gaseous Diffusion Plant

    2012-01-23

    ... other facilities of the Paducah Gaseous Diffusion Plant, located in McCracken County, KY, published at (30 FR 13287, October 19, 1965 and at 45 FR 30106, May 7, 1980) are amended by substitution of the... of 229 Boundary Revision at the Paducah Gaseous Diffusion Plant AGENCY: Department of Energy...

  13. 22 CFR 229.210 - Military and merchant marine educational institutions.

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Military and merchant marine educational... Coverage § 229.210 Military and merchant marine educational institutions. These Title IX regulations do not... service of the United States or for the merchant marine....

  14. BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surface

    Bone marrow stromal antigen 2 (BST2), an interferon-inducible antiviral factor, has been shown to block the release of various enveloped viruses from cells. It has also been identified as an innate immune system component. Most enveloped viruses subject to BST2 restriction bud at the plasma membrane. Here we report our findings that (a) the production of human coronavirus 229E (HCoV-229E) progeny viruses, whose budding occurs at the ER-Golgi intermediate compartment (ERGIC), markedly decreases in the presence of BST2; and (b) BST2 knockdown expression results in enhanced HCoV-229E virion production. Electron microscopy analyses indicate that HCoV-229E virions are tethered to cell surfaces or intracellular membranes by BST2. Our results suggest that BST2 exerts a broad blocking effect against enveloped virus release, regardless of whether budding occurs at the plasma membrane or intracellular compartments. - Highlights: • BST2 knockdown expression results in enhanced HCoV-229E egress. • HCoV-229E virions are tethered to cell surfaces or intracellular membranes by BST2. • HCoV-229E infection at high MOI can significantly downregulate HeLa BST2 and rescue HIV-1 egress

  15. BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surface

    Wang, Shiu-Mei [Department of Medical Research and Education, Taipei Veterans General Hospital and Institute of Clinical Medicine, Taipei 11217, Taiwan (China); Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan (China); Huang, Kuo-Jung [Department of Medical Research and Education, Taipei Veterans General Hospital and Institute of Clinical Medicine, Taipei 11217, Taiwan (China); Wang, Chin-Tien, E-mail: chintien@ym.edu.tw [Department of Medical Research and Education, Taipei Veterans General Hospital and Institute of Clinical Medicine, Taipei 11217, Taiwan (China); Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan (China)

    2014-01-20

    Bone marrow stromal antigen 2 (BST2), an interferon-inducible antiviral factor, has been shown to block the release of various enveloped viruses from cells. It has also been identified as an innate immune system component. Most enveloped viruses subject to BST2 restriction bud at the plasma membrane. Here we report our findings that (a) the production of human coronavirus 229E (HCoV-229E) progeny viruses, whose budding occurs at the ER-Golgi intermediate compartment (ERGIC), markedly decreases in the presence of BST2; and (b) BST2 knockdown expression results in enhanced HCoV-229E virion production. Electron microscopy analyses indicate that HCoV-229E virions are tethered to cell surfaces or intracellular membranes by BST2. Our results suggest that BST2 exerts a broad blocking effect against enveloped virus release, regardless of whether budding occurs at the plasma membrane or intracellular compartments. - Highlights: • BST2 knockdown expression results in enhanced HCoV-229E egress. • HCoV-229E virions are tethered to cell surfaces or intracellular membranes by BST2. • HCoV-229E infection at high MOI can significantly downregulate HeLa BST2 and rescue HIV-1 egress.

  16. Quantum interference effects in an ensemble of $^{229}$Th nuclei interacting with coherent light

    Das, Sumanta; Keitel, Christoph H

    2013-01-01

    As a unique feature, the $^{229}$Th nucleus has an isomeric transition in the vacuum ultraviolet that can be accessed by optical lasers. The interference effects occurring in the interaction between coherent optical light and an ensemble of $^{229}$Th nuclei are investigated theoretically. We consider the scenario of nuclei doped in vacuum ultraviolet-vacuum ultraviolet transparent crystals and take into account the effect of different doping sites and therefore different lattice fields that broaden the nuclear transition width. This effect is shown to come in interplay with interference effects due to the hyperfine splitting of the ground and isomeric nuclear states. We investigate possible experimentally available situations involving two-, three- and four-level schemes of quadrupole sublevels of the ground and isomeric nuclear states coupling to one or two coherent fields. Specific configurations which offer clear signatures of the isomer excitation advantageous for the more precise experimental determinat...

  17. 49 CFR Appendix B to Part 229 - Schedule of Civil Penalties 1

    2010-10-01

    ... 49 CFR part 209, appendix A. Failure to observe any condition for movement set forth in § 229.9 will...) Drilled telltale holes in welded main reservoirs 2,500 5,000 (d) Biennial tests of aluminum main... 5,000 7,500 (k) Crack of less than 1″ 5,000 7,500 (1) Crack of less than 1″ 2,500 5,000 (2) Crack...

  18. Molecular Abundances in the Atmosphere of the T Dwarf Gl 229B

    Saumon, D S; Leggett, S K; Marley, M S; Freedman, R S; Lodders, K; Fegley, B; Sen-Gupta, S K

    2000-01-01

    We present new, high resolution, infrared spectra of the T dwarf Gliese 229B in the J, H, and K bandpasses. We analyze each of these as well as previously published spectra to determine its metallicity and the abundances of NH3 and CO in terms of the surface gravity of Gl 229B, which remains poorly constrained. The metallicity increases with increasing gravity and is below the solar value unless Gl 229B is a high-gravity brown dwarf with log g(cgs) ~ 5.5. The NH3 abundance is determined from both the H and the K band spectra which probe two different levels in the atmosphere. We find that the abundance from the K band data is well below that expected from chemical equilibrium, which we interpret as strong evidence for dynamical transport of NH3 in the atmosphere. This is consistent with the previous detection of CO and provides additional constraints on the dynamics of the atmosphere of this T dwarf.

  19. Anomalous Hyperfine Structure of the $^{229}$Th Ground-State Doublet in Muonic Atom

    Tkalya, E V

    2016-01-01

    The hyperfine splitting of the ground and low-energy $3/2^+(7.8 \\pm 0.5$ eV) levels in the $^{229}$Th nucleus in muonic atom ($\\mu^-_{1S_{1/2}}{}^{229}$Th$)^*$ has been calculated considering the distribution of the nuclear magnetization in the framework of collective nuclear model with the wave functions of the Nilsson model for the unpaired neutron. It is shown that (a) the hyperfine splitting of the $3/2^+$ isomeric state is anomalously weak, and the reduction of hyperfine structure in comparison with the model of a point nuclear magnetic dipole is close to 100\\%, (b) partial inversion of levels of the $^{229}$Th ground-state doublet and spontaneous decay of the ground state with excitation of the isomeric state take place, (c) the energy of the isomeric transition lies in the range of 120--140 eV, which makes possible the direct observation of the transition, registration of conversion electrons and measurement of the nuclear matrix element.

  20. Anomalous magnetic hyperfine structure of the 229Th ground-state doublet in muonic atoms

    Tkalya, E. V.

    2016-07-01

    The magnetic hyperfine (MHF) splitting of the ground and low-energy 3 /2+(7.8 ±0.5 eV) levels in the 229Th nucleus in the muonic atom (μ1S1 /2 -229Th) * is calculated considering the distribution of the nuclear magnetization in the framework of the collective nuclear model with wave functions of the Nilsson model for the unpaired neutron. It is shown that (a) deviation of the MHF structure of the isomeric state exceeds 100% from its value for a pointlike nuclear magnetic dipole (the order of sublevels is reversed); (b) partial inversion of levels of the 229Th ground-state doublet and spontaneous decay of the ground state to the isomeric state occur; (c) the E 0 transition, which is sensitive to differences in the mean-square charge radii of the doublet states, is possible between mixed sublevels with F =2 ; and (d) MHF splitting of the 3 /2+ isomeric state may be in the optical range for certain values of the intrinsic gK factor and a reduced probability of a nuclear transition between the isomeric and the ground states.

  1. Generator method of 225Ac production without a carrier for nuclear medicine

    The two-steps isotope generator scheme of 225Ac production from 229Th has been developed. The first step is used for separation of thorium, actinium, radium and daughter decay products (DDP), and removals of parent radionuclide. The second step provides additional separation of actinium from traces of radium and DDP, and conversion of actinium in the nitrate form. The chosen solutions provide optimal conditions for carry out of process. The yield of the 225Ac was 99.9% at minimal losses of parent 229Th (less than 0.1%)

  2. Direct two-photon excitation of isomeric transition in thorium-229 nucleus

    Romanenko, V. I.; Udoviskaya, Ye. G.; Yatsenko, L. P.; Romanenko, A. V.; Litvinov, A. N.; Kazakov, G. A.

    2012-01-01

    A possibility of the two-photon excitation of an isomeric state in a nucleus of thorium-229 has been discussed. The fluorescence intensity of the excitation is demonstrated to be identical for the irradiation of nuclei with either monochromatic light or polychromatic radiation consisting of a sequence of short light pulses of the same intensity. The two-photon excitation of Th^{3+} ion in an electromagnetic trap with a focused laser beam with a wavelength of about 320 nm and power of 100 mW c...

  3. The rotational bands in the nuclei 229Pa and 231Pa

    Experimental evidence is presented for the similarity between the rotational spectra built on the 1/2-[530] state in 231Pa, where the 3/2- member of the band forms the ground state, and in 229Pa, where this state lies within 20 keV of the ground state. Our findings are in contrast with earlier work invoking octupole deformations in the ground state to account for the different positions of low-lying Nilsson states in the two isotopes. (author)

  4. Improved Value for the Energy Splitting of the Ground-State Doublet in the Nucleus 229mTh

    We have made an improved estimate of the 229mTh isomer energy. The new value, 7.8(5) eV, includes an estimate of possible spectral contamination effects due to the out-of-band E2 transition from the 42.43-keV 7/2+ member of the (633) ground state band to the 3/2+ (631) 229mTh bandhead and so a weak and unresolved transition a few eV different in energy. We estimate a 2% branching ratio for this unobserved transition in the 42.43-keV 7/2+ (633) deexcitation. The excitation of the 229mTh level is increased from the previously reported value of 7.6(5) eV to the new best value of 7.8(5) eV when this branch is included in the analysis

  5. Characterization of the expression and immunogenicity of the ns4b protein of human coronavirus 229E

    Chagnon, F; Lamarre, A; Lachance, C;

    1998-01-01

    and immunogenicity of the ns4b gene product from strain 229E of human coronavirus (HCV-229E), a respiratory virus with a neurotropic potential. The gene was cloned and expressed in bacteria. A fusion protein of ns4b with maltose-binding protein was injected into rabbits to generate specific antibodies...... that were used to demonstrate the expression of ns4b in HCV-229E-infected cells using flow cytometry. Given a previously reported contiguous five amino acid shared region between ns4b and myelin basic protein, a purified recombinant histidine-tagged ns4b protein and (or) human myelin basic protein were...... injected into mice to evaluate whether myelin-viral protein cross-reactive antibody responses could be generated. Each immunogen induced specific but not cross-reactive antibodies. We conclude that ns4b is expressed in infected cells and is immunogenic, although this does not involve amino acids shared...

  6. Continuous-wave, single-frequency 229  nm laser source for laser cooling of cadmium atoms.

    Kaneda, Yushi; Yarborough, J M; Merzlyak, Yevgeny; Yamaguchi, Atsushi; Hayashida, Keitaro; Ohmae, Noriaki; Katori, Hidetoshi

    2016-02-15

    Continuous-wave output at 229 nm for the application of laser cooling of Cd atoms was generated by the fourth harmonic using two successive second-harmonic generation stages. Employing a single-frequency optically pumped semiconductor laser as a fundamental source, 0.56 W of output at 229 nm was observed with a 10-mm long, Brewster-cut BBO crystal in an external cavity with 1.62 W of 458 nm input. Conversion efficiency from 458 nm to 229 nm was more than 34%. By applying a tapered amplifier (TA) as a fundamental source, we demonstrated magneto-optical trapping of all stable Cd isotopes including isotopes Cd111 and Cd113, which are applicable to optical lattice clocks. PMID:26872168

  7. Enhanced effect of quark mass variation in 229Th and limits from Oklo data

    Flambaum, V V

    2008-01-01

    The effects of the variation of the dimensionless strong interaction parameter Xq=mq/Lambda{QCD} (mq is the quark mass, Lambda{QCD} is the QCD scale) are enhanced about 1.5 x 10**5 times in the 7.6 eV "nuclear clock" transition between the ground and first excited states in the 229Th nucleus and about 1 x 10**8 times in the relative shift of the 0.1 eV compound resonance in 150Sm.The best terrestrial limit on the temporal variation of the fundamental constants, |delta(Xq)/Xq| < 4 x 10**-9 at 1.8 billion years ago (|d(Xq/Xq)/dt| < 2.2 x 10**-18 y**-1), is obtained from the shift of this Sm resonance derived from the Oklo natural nuclear reactor data. The results for 229Th and 150Sm are obtained by extrapolation from light nuclei where the many-body calculations can be performed more accurately. The errors produced by such extrapolation may be smaller than the errors of direct calculations in heavy nuclei. The extrapolation results are compared with the "direct" estimates obtained using the Walecka model....

  8. Radiative lifetime and energy of the low-energy isomeric level in 229Th

    Tkalya, E. V.; Schneider, Christian; Jeet, Justin; Hudson, Eric R.

    2015-11-01

    We estimate the range of the radiative lifetime and energy of the anomalous, low-energy 3 /2+(7.8 ±0.5 eV) state in the 229Th nucleus. Our phenomenological calculations are based on the available experimental data for the intensities of M 1 and E 2 transitions between excited levels of the 229Th nucleus in the Kπ[N nZΛ ] =5 /2+[633 ] and 3 /2+[631 ] rotational bands. We also discuss the influence of certain branching coefficients, which affect the currently accepted measured energy of the isomeric state. From this work, we establish a favored region, 0.66 ×106seV3/ω3≤τ ≤2.2 ×106seV3/ω3 , where the transition lifetime τ as a function of transition energy ω should lie at roughly the 95% confidence level. Together with the result of Beck et al. [LLNL-PROC-415170 (2009)], we establish a favored area where transition lifetime and energy should lie at roughly the 90% confidence level. We also suggest new nuclear physics measurements, which would significantly reduce the ambiguity in the present data.

  9. Broad-Line Reverberation in the Kepler-Field Seyfert Galaxy Zw 229-015

    Barth, A J; Malkan, M A; Filippenko, A V; Li, W; Gorjian, V; Joner, M D; Bennert, V N; Botyanszki, J; Cenko, S B; Childress, M; Choi, J; Comerford, J M; Cucciara, A; da Silva, R; Duchene, G; Fumagalli, M; Ganeshalingam, M; Gates, E L; Gerke, B F; Griffith, C V; Harris, C; Hintz, E G; Hsiao, E; Kandrashoff, M T; Keel, W C; Kirkman, D; Kleiser, I K W; Laney, C D; Lee, J; Lopez, L; Lowe, T B; Moody, J W; Morton, A; Nierenberg, A M; Nugent, P; Pancoast, A; Rex, J; Rich, R M; Silverman, J M; Smith, G H; Sonnenfeld, A; Suzuki, N; Tytler, D; Walsh, J L; Woo, J -H; Yang, Y; Zeisse, C

    2011-01-01

    The Seyfert 1 galaxy Zw 229-015 is among the brightest active galaxies being monitored by the Kepler mission. In order to determine the black hole mass in Zw 229-015 from H-beta reverberation mapping, we have carried out nightly observations with the Kast Spectrograph at the Lick 3m telescope during the dark runs from June through December 2010, obtaining 54 spectroscopic observations in total. We have also obtained nightly V-band imaging with the Katzman Automatic Imaging Telescope at Lick Observatory and with the 0.9m telescope at the Brigham Young University West Mountain Observatory over the same period. We detect strong variability in the source, which exhibited more than a factor of 2 change in broad H-beta flux. From cross-correlation measurements, we find that the H-beta light curve has a rest-frame lag of 3.86(+0.69,-0.90) days with respect to the V-band continuum variations. We also measure reverberation lags for H-alpha and H-gamma and find an upper limit to the H-delta lag. Combining the H-beta la...

  10. Activity determination of 229Th by means of liquid scintillation counting

    Liquid scintillation measurements of 229Th in radioactive equilibrium with its progenies were carried out. The counting efficiency was determined by means of a free parameter model. The measurements were made in a custom-built triple-to-double coincidence ratio (TDCR) system. In addition, a new portable mini-TDCR system with three channel photomultipliers and two commercial counters were tested. The decay of the short-lived 213Po requires great care, since it often occurs during the dead time of the counter systems. Also the rather short-lived 217At may decay during the dead time caused by 221Fr decay events. The overall counting efficiency of the TDCR system of PTB was found to be about 700% (depending on the degree of chemical quenching) and the relative standard uncertainty of the activity concentration was found to be about 0.23%. The determined activity concentration was compared with the outcome of alpha spectrometry under defined solid angle and excellent agreement was found. The TDCR efficiency calculations can be easily adapted to activity determinations of 225Ra or 225Ac in equilibrium with their progenies. - Highlights: • The activity of a 229Th solution was determined by means of TDCR measurements. • The relative standard uncertainty was found to be 0.23%. • A new portable mini-TDCR system was successfully tested. • Results are in good agreement with the outcome from alpha spectrometry

  11. CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse

    Romero, [No Value; Zapater, N; Calvo, M; Kalko, SG; de la Fuente, MA; Tovar, [No Value; Ockeloen, C; Pizcueta, P; Engel, P

    2005-01-01

    CD229 is a member of the CD150 family of the Ig superfamily expressed on T and B cells. Receptors of this family regulate cytokine production and cytotoxicity of lymphocytes and NK cells. The cytoplasmic tail of CD229 binds to SAP, a protein that is defective in X-linked lymphoproliferative syndrome

  12. Creation of inverse population in the 229Th ground-state doublet by means of a narrowband laser

    A new method for obtaining inverse population between quadrupole sublevels of the ground state 5/2+(0.0) and the isomeric state 3/2+(7.6 eV) of the 229Th nucleus in a dielectric crystal with a large band gap by means of an external source of VUV radiation is proposed. The method is based on an efficient depopulation of the upper sublevels of the ground state of 229Th by resonant photons from a narrowband laser or a broader tunable free electron laser. The sublevels of the isomeric state play the role of intermediate states. The proposed scheme of optical pumping (1) results in inverse population of nuclear sublevels without using extremely low temperatures, and (2) shows a new means of creating a gamma-ray laser of optical range at the nuclear transition in 229Th (a) in crystals with isovalent substitution of host ions (e.g. Si4+ ions in the SiO2 crystal replaced by the 229Th4+ ions) and (b) in crystals such as Na2ThF6, where the substitution is not necessary. (letter)

  13. A VUV detection system for the direct photonic identification of the first excited isomeric state of 229Th

    Seiferle, Benedict; von der Wense, Lars; Laatiaoui, Mustapha; Thirolf, Peter G.

    2016-03-01

    With an expected energy of 7.6(5) eV, 229Th possesses the lowest excited nuclear state in the landscape of all presently known nuclei. The energy corresponds to a wavelength of about 160 nm and would conceptually allow for an optical laser excitation of a nuclear transition. We report on a VUV optical detection system that was designed for the direct detection of the isomeric ground-state transition of 229Th. 229(m)Th ions originating from a 233U α-recoil source are collected on a micro electrode that is placed in the focus of an annular parabolic mirror. The latter is used to parallelize the UV fluorescence that may emerge from the isomeric ground-state transition of 229Th. The parallelized light is then focused by a second annular parabolic mirror onto a CsI-coated position-sensitive MCP detector behind the mirror exit. To achieve a high signal-to-background ratio, a small spot size on the MCP detector needs to be achieved. Besides extensive ray-tracing simulations of the optical setup, we present a procedure for its alignment, as well as test measurements using a D2 lamp, where a focal-spot size of ≈100 μm has been achieved. Assuming a purely photonic decay, a signal-to-background ratio of ≈7000:1 could be achieved.

  14. 32 CFR 229.7 - Notification to Indian tribes of possible harm to, or destruction of, sites on public lands...

    2010-07-01

    ... to, or destruction of, sites on public lands having religious or cultural importance. 229.7 Section... of possible harm to, or destruction of, sites on public lands having religious or cultural importance... consider the site as having religious or cultural importance. Such notice shall not be deemed a...

  15. A VUV detection system for the direct photonic identification of the first excited isomeric state of $^{229}$Th

    Seiferle, Benedict; Laatiaoui, Mustapha; Thirolf, Peter G

    2015-01-01

    With an expected energy of 7.6(5) eV, $^{229}$Th possesses the lowest excited nuclear state in the landscape of all presently known nuclei. The energy corresponds to a wavelength of about 160 nm and would conceptually allow for an optical laser excitation of a nuclear transition. We report on a VUV optical detection system that was designed for the direct detection of the isomeric ground-state transition of $^{229}$Th. $^{229(m)}$Th ions originating from a $^{233}$U $\\alpha$-recoil source are collected on a micro electrode that is placed in the focus of an annular parabolic mirror. The latter is used to parallelize the UV fluorescence that may emerge from the isomeric ground-state transition of $^{229}$Th. The parallelized light is then focused by a second annular parabolic mirror onto a CsI-coated position-sensitive MCP detector behind the mirror exit. To achieve a high signal-to-background ratio, a small spot size on the MCP detector needs to be achieved. Besides extensive ray-tracing simulations of the opt...

  16. Direct two-photon excitation of isomeric transition in thorium-229 nucleus

    Romanenko, V I; Yatsenko, L P; Romanenko, A V; Litvinov, A N; Kazakov, G A

    2012-01-01

    A possibility of the two-photon excitation of an isomeric state in a nucleus of thorium-229 has been discussed. The fluorescence intensity of the excitation is demonstrated to be identical for the irradiation of nuclei with either monochromatic light or polychromatic radiation consisting of a sequence of short light pulses of the same intensity. The two-photon excitation of Th^{3+} ion in an electromagnetic trap with a focused laser beam with a wavelength of about 320 nm and power of 100 mW can lead to the absorption saturation, at which the fluorescence emission with the frequency of the transition in a nucleus is maximal. In crystals doped with Th^{4+} to a concentration of about 10^{18} cm^{-3} and irradiated with a laser radiation 10 W in power, the emission of several photons per second with a wavelength of about 160 nm becomes possible.

  17. Kinematics and duty cycles of the SM-229 force-reflecting servomanipulator

    This report describes the first known experimental study of servomanipulator duty cycles to appear in the literature. The servomanipulator used was TeleOperator Systems Model SM-229. The experimental approach used was to record the joint positions and motor currents of the right slave arm at a rate of 10 Hz over about 50 h of typical remote manipulation operations. The results are presented as position usage patterns in joint and real-world coordinates, time-use histograms of joint velocities and motor currents, and three-dimensional mechanical power histograms for each joint. All results are presented in dimensionless form, scaled to the design ranges of the manipulator and the total operation time recorded. Applications of this study include improvements in kinematic ranges, gear reductions, motor sizings, drive configurations, and stress relief. Included in appendices are an uncertainty analysis, calibration procedures, and analysis of the kinematics of the manipulator. 12 refs., 42 figs., 15 tabs

  18. Energy splitting of the ground-state doublet in the nucleus 229Th.

    Beck, B R; Becker, J A; Beiersdorfer, P; Brown, G V; Moody, K J; Wilhelmy, J B; Porter, F S; Kilbourne, C A; Kelley, R L

    2007-04-01

    The energy splitting of the 229Th ground-state doublet is measured to be 7.6+/-0.5 eV, significantly greater than earlier measurements. Gamma rays produced following the alpha decay of 233U (105 muCi) were counted in the NASA/electron beam ion trap x-ray microcalorimeter spectrometer with an experimental energy resolution of 26 eV (FWHM). A difference technique was applied to the gamma-ray decay of the 71.82 keV level that populates both members of the doublet. A positive correction amounting to 0.6 eV was made for the unobserved interband decay of the 29.19 keV state (29.19-->0 keV). PMID:17501268

  19. Detection of Chlamydia trachomatis inclusions in McCoy and HeLa-229 cells: an alternative staining technique using toluidine blue.

    Mohammed, N R; Hillary, I B

    1984-01-01

    Toluidine blue staining was used to detect Chlamydia trachomatis inclusions in both McCoy and HeLa-229 cells from clinical specimens. This method was more sensitive than iodine staining for detecting C trachomatis inclusions in both McCoy and HeLa-229 cells and also more sensitive than Giemsa staining for detecting chlamydial inclusions in HeLa-229 cells. While its sensitivity for detection of chlamydial inclusions in McCoy cells is equal to that of Giemsa staining, toluidine blue staining is...

  20. Update of 233U, 229-232Th and 230-233Pa Fission Data

    The influence of the 235U(n,f) and 239Pu(n,f) prompt fission neutron spectra (PFNS) on modeling of integral benchmarks was estimated to be significant. For 233U(n,f) PFNS similar sensitivities could be envisaged. For the variety of Th/U fuels and systems, ranging from metal fast to deep thermal solutions, large positive/negative swings in calculated Keff can be expected. Th/U fuelled core criticality calculations would be sensitive to the modelled soft tail of fission neutrons or deficiency of hard tail fission neutrons, as revealed for U and Pu fuels. The deficiency of the 233U(nth,f) PFNS, adopted for the ENDF/B-VII.0. could be traced back to the 'propagation' of calculated 235U(nth,f) PFNS shape at En= 0.5 MeV. At higher energies, average energies of PFNS coincide only at ∼5 MeV, at other En the average energies and spectra shapes are drastically different. However, it might be argued that the response of the criticality benchmark calculations for the 233U thermal and fast systems would be similar to that observed for the PFNS of 239Pu. Our approach allowed to solve the longstanding problem of inconsistency of 235U integral data testing and differential prompt fission neutron spectra data, a similar approach may hold for 233U. Using modified PFNS, we may avoid arbitrary tweaking of neutron cross sections or neutron multiplicities for Th/U fuel-cycle related nuclides (233U, 229,230,231,232Th and 230,231,232,233Pa) to compensate the ill-defined shape of 233U PFNS. For metal fast benchmarks much would depend on the inelastic scattering cross section of 233U, which should be considered rather uncertain at the moment. The unrealistic evaluations of poorly investigated cross sections related to the Th/U fuel cycle could be excluded by consistent analysis of the available fission data base. The evaluation of 229,230,231,232Th(n,f) and 230,231,232,233Pa(n,f) cross sections could be supplemented by description of surrogate and ratio surrogate fission data, coming from

  1. Results of a direct search using synchrotron radiation for the low-energy $^{229}$Th nuclear isomeric transition

    Jeet, Justin; Sullivan, Scott T; Rellergert, Wade G; Mirzadeh, Saed; Cassanho, A; Jenssen, H P; Tkalya, Eugene V; Hudson, Eric R

    2015-01-01

    We report the results of a direct search for the $^{229}$Th ($I^{p} = 3/2^+\\leftarrow 5/2^+$) nuclear isomeric transition, performed by exposing $^{229}$Th-doped LiSrAlF$_6$ crystals to tunable vacuum-ultraviolet synchrotron radiation and observing any resulting fluorescence. We also use existing nuclear physics data to establish a range of possible transition strengths for the isomeric transition. We find no evidence for the thorium nuclear transition between $7.3 \\mbox{eV}$ and $8.8 \\mbox{eV}$ with transition lifetime $(1-2)\\mbox{s} \\lesssim \\tau \\lesssim (2000-5600)\\mbox{s}$. This measurement excludes roughly half of the favored transition search area and can be used to direct future searches.

  2. Results of a Direct Search Using Synchrotron Radiation for the Low-Energy (229)Th Nuclear Isomeric Transition.

    Jeet, Justin; Schneider, Christian; Sullivan, Scott T; Rellergert, Wade G; Mirzadeh, Saed; Cassanho, A; Jenssen, H P; Tkalya, Eugene V; Hudson, Eric R

    2015-06-26

    We report the results of a direct search for the (229)Th (I(π)=3/2(+)←5/2(+)) nuclear isomeric transition, performed by exposing (229)Th-doped LiSrAlF(6) crystals to tunable vacuum-ultraviolet synchrotron radiation and observing any resulting fluorescence. We also use existing nuclear physics data to establish a range of possible transition strengths for the isomeric transition. We find no evidence for the thorium nuclear transition between 7.3 eV and 8.8 eV with transition lifetime (1-2) s≲τ≲(2000-5600)  s. This measurement excludes roughly half of the favored transition search area and can be used to direct future searches. PMID:26197124

  3. Above 8GHz Static T-Flip-Flop Operation using FT=22.9GHz GaAs MESFETs

    Riishøj, J; Danielsen, Per Lander

    1992-01-01

    A static SCFL Toggle Flip-Flop GaAs IC having maximum operating frequency of Fdiv=8.25GHz has been designed using a commercially available GaAs MESFET foundry service. The average Ft for the present wafer is Ft=22.9GHz giving a very high Fdiv/Ft-ratio of Fdiv/Ft=0.36. In addition output voltage...

  4. Involvement of Aminopeptidase N (CD13) in Infection of Human Neural Cells by Human Coronavirus 229E

    Lachance, Claude; Arbour, Nathalie; Cashman, Neil R.; Talbot, Pierre J

    1998-01-01

    Attachment to a cell surface receptor can be a major determinant of virus tropism. Previous studies have shown that human respiratory coronavirus HCV-229E uses human aminopeptidase N (hAPN [CD13]) as its cellular receptor for infection of lung fibroblasts. Although human coronaviruses are recognized respiratory pathogens, occasional reports have suggested their possible neurotropism. We have previously shown that human neural cells, including glial cells in primary cultures, are susceptible t...

  5. Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E

    Sharon K. Hietala

    2012-12-01

    Full Text Available In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A putative additional open-reading frame was identified between the nucleocapsid gene and 3'UTR. The ACoV was genetically most similar to the common human coronavirus (HCoV 229E with 92.2% nucleotide identity over the entire genome. A comparison of spike gene sequences from ACoV and from HCoV-229E isolates recovered over a span of five decades showed the ACoV to be most similar to viruses isolated in the 1960’s to early 1980’s. The true origin of the ACoV is unknown, however a common ancestor between the ACoV and HCoV-229E appears to have existed prior to the 1960’s, suggesting virus transmission, either as a zoonosis or anthroponosis, has occurred between alpacas and humans.

  6. Extraction of chymosin produced by solid state fermentation of mucor MJ229%毛霉MJ229固态发酵凝乳酶提取工艺研究

    王艳萍; 张殿伟; 程巧玲; 白小佳

    2011-01-01

    Chymosin is a key enzyme in cheese production which causes milk curd.It plays a very important role in the formation of texture and flavor in cheese.With the development of cheese industry, chymosin made by traditional method is not sufficient for its production, so the researchers are looking for the new sources of chymosin.MJ229 can produce chymosin, that was isolated from glutinous rice wine which was a traditional food in south of China.This paper studied the extraction process of chymosin from the Mucor MJ229 solid state fermentation broth, using single factor analysis of the extraction time, salt concentration, extraction temperature, extraction times which affect extraction of chymosin.The results showed that the optimized extraction conditions were: the temperature is 40℃, NaCl concentration is 0.3 mol/L, extracted 20min for 3 times.%凝乳酶是干酪生产中的关键性酶.它对干酪的质构形成及特有风味的形成有非常重要的作用.随着干酪工业的不断发展,传统来源的凝乳酶已远不能满足生产需要,各国研究者不断地寻找新的来源.霉菌MJ229是从我国传统食品江米酒酒醪中筛选得到的一株凝乳酶高产菌株.本论文对霉菌MJ229固态发酵物中凝乳酶的提取工艺进行了研究,分别研究了提取时间、食盐浓度、提取温度、次数对固态发酵液中凝乳酶提取效果的影响.结果表明,霉菌MJ229固态发酵中凝乳酶在温度40℃条件下,用0.3mol/L的NaCl溶液提取20min,提取3次的效果为最好.

  7. Excitation of the {sup 229m}Th nuclear isomer via resonance conversion in ionized atoms

    Karpeshin, F. F., E-mail: fkarpeshin@gmail.com [D.I. Mendeleev Institute for Metrology (VNIIM) (Russian Federation); Trzhaskovskaya, M. B. [National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute (Russian Federation)

    2015-09-15

    Pressing problems concerning the optical pumping of the 7.6-eV {sup 229m}Th nuclear isomer, which is a candidate for a new nuclear optical reference point for frequencies, are examined. Physics behind the mechanism of the two-photon optical pumping of the isomer is considered. It is shown that, irrespective of the pumping scheme, a dominant contribution comes, in accord with what was proven earlier for the 3.5-eV isomer, from the resonance 8s–7s transition. Details of an optimum experimental scheme are discussed. It is shown that, after isomer excitation, the atom involved remains with a high probability in an excited state at an energy of about 0.5 eV rather than in the ground state, the required energy of the two photons being equal to the energy of the nuclear level plus the energy of the lowest 7s state of the atom. The estimated pumping time is about 1.5 s in the case where the field strength of each laser is 1 V/cm.

  8. Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas

    Marta Mellai

    2013-01-01

    Full Text Available The epithelial membrane protein 3 (EMP3 is a candidate tumor suppressor gene in the critical region 19q13.3 for several solid tumors, including tumors of the nervous systems. The aim of this study was to investigate the EMP3 promoter hypermethylation status in a series of 229 astrocytic and oligodendroglial tumors and in 16 GBM cell lines. The analysis was performed by methylation-specific PCR and capillary electrophoresis. Furthermore, the EMP3 expression at protein level was evaluated by immunohistochemistry and Western blotting analysis. Associations of EMP3 hypermethylation with total 1p/19q codeletion, MGMT promoter hypermethylation, IDH1/IDH2 and TP53 mutations, and EGFR amplification were studied, as well as its prognostic significance. The EMP3 promoter hypermethylation has been found in 39.5% of gliomas. It prevailed in low-grade tumors, especially in gliomas with an oligodendroglial component, and in sGBMs upon pGBMs. In oligodendroglial tumors, it was strongly associated with both IDH1/IDH2 mutations and total 1p/19q codeletion and inversely with EGFR gene amplification. No association was found with MGMT hypermethylation and TP53 mutations. In the whole series, the EMP3 hypermethylation status correlated with 19q13.3 loss and lack of EMP3 expression at protein level. A favorable prognostic significance on overall survival of the EMP3 promoter hypermethylation was found in patients with oligodendroglial tumors.

  9. Uranium doped LiSAF as a precursor for a 229 Th nuclear clock experiment

    Meyer, Edmund; Hehlen, Markus; Barker, Beau; Collins, Lee; Zhao, Xinxin

    2016-05-01

    We experimentally and numerically study the simple idea of growing 233 U doped LiSAF crystals. The micro-pulling-down technique is used to grow U:LiSAF single crystals with a high number density of U ions. The crystals are in the shape of rods that are geometrically well matched for imaging onto the spectrophotometer input slit. Growth is performed in an RF-heated chamber under argon inert atmosphere at elevated pressure. This reduces the evaporation of LiF and AlF3 from the melt and crystal surface during growth which otherwise tends to degrade the crystal quality. Through physical arguments and robust numerical calculation we determine the oxidation state of the U ion to likely be trivalent and occupying the Sr site. Charge compensation is numerically studied through F interstitials and Li vacancies. We determine the energetically most favorable state for U:LiSAF and investigate the effects upon α-decay of 233 U to 229 Th, which ~ 2% of the time is in the excited isomeric state. Additional charge compensation mechanisms are needed to accommodate the Th4+ ground oxidation state and we investigate F interstitial as well as Li vacancy. The band structure is calculated and analyzed for select cases.

  10. On the 7.8 eV isomer transition in {sup 229}Th

    Stellmer, Simon; Schreitl, Matthias; Winkler, Georg; Tscherne, Christoph; Kazakov, Georgy; Schumm, Thorsten [VCQ and Atominstitut / TU Wien, Vienna (Austria); Fleischmann, Andreas; Gastaldo, Loredana; Pabinger, Andreas; Enss, Christian [KIP, University of Heidelberg (Germany)

    2014-07-01

    The best atom clocks today employ an optical transition between two electronic states of an atom or ion. It seems tantalizing to utilize a nuclear transition instead, as such a transition would be well-isolated from collisional, electronic, and even chemical perturbations from the environment. In addition, such transitions are expected to be very sensitive probes of drifts in fundamental constants. The only isotope known to possess an isomer transition in the optical domain is the radioactive element {sup 229}Th. Various attempts have been carried out to measure or calculate the transition energy and linewidth. To date, all of these measurements have been refuted, corrected, or at least strongly debated. While a direct evidence of this transition is still pending, its commonly agreed-upon energy is 7.8(5) eV. In this talk, we present the current status of a novel measurement campaign. In a concerted effort of the Heidelberg and Vienna groups, we use a microcalorimeter to measure the spectrum of gamma photons originating from the decay of excited nuclear states. A double-peaked structure would reveal the existence of the isomer state and allow us to measure its energy with unprecedented precision.

  11. Prospects for measuring the {sup 229}Th isomer energy using a metallic magnetic microcalorimeter

    Kazakov, G.A., E-mail: kazakov.george@gmail.com [Wolfgang Pauli Institute, Univ. Wien – UZA 4 Nordbergstrasse 15, A, 1090 Vienna (Austria); Vienna Center for Quantum Science and Technology, Atominstitut, TU Wien, Stadionallee 2, 1020 Vienna (Austria); Schauer, V.; Schwestka, J.; Stellmer, S.P.; Sterba, J.H. [Vienna Center for Quantum Science and Technology, Atominstitut, TU Wien, Stadionallee 2, 1020 Vienna (Austria); Fleischmann, A.; Gastaldo, L.; Pabinger, A.; Enss, C. [Kirchhoff-Institute for Physics, Heidelberg University, INF 227, 69120 Heidelberg (Germany); Schumm, T. [Vienna Center for Quantum Science and Technology, Atominstitut, TU Wien, Stadionallee 2, 1020 Vienna (Austria)

    2014-01-21

    The Thorium-229 isotope features a nuclear isomer state with an extremely low energy. The currently most accepted energy value, 7.8±0.5 eV, was obtained from an indirect measurement using a NASA x-ray microcalorimeter with an instrumental resolution 26 eV. We study, how state-of-the-art magnetic metallic microcalorimeters with an energy resolution down to a few eV can be used to measure the isomer energy. In particular, resolving the 29.18 keV doublet in the γ-spectrum following the α-decay of Uranium-233, corresponding to the decay into the ground and isomer state, allows to measure the isomer transition energy without additional theoretical input parameters, and increase the energy accuracy. We study the possibility of resolving the 29.18 keV line as a doublet and the dependence of the attainable precision of the energy measurement on the signal and background count rates and the instrumental resolution.

  12. Prospects for measuring the $^{229}$Th isomer energy using a metallic magnetic microcalorimeter

    Kazakov, G A; Sterba, J H; Fleischmann, A; Enss, C; Schumm, T

    2013-01-01

    The Thorium-229 isotope features a nuclear isomer state with extremely low energy. The currently most accepted energy value, $7.8 \\pm 0.5$\\,eV, was obtained from an indirect measurements using a NASA x-ray microcalorimeter with instrumental resolution (FWHM) of 26\\,eV. We study, how state-of-the-art magnetic metallic microcalorimeters with an energy resolution down to a few eV can be used to measure the isomer energy. Resolving the 29.18\\,keV doublet in the $\\gamma$-spectrum following the $\\alpha$-decay of Uranium-233, corresponding to the decay into the ground and isomer state, allows to measure the isomer transition energy without additional theoretical input parameters and increase the energy accuracy. We study the dependence of the attainable precision of this measurement on the signal and background count rates and the instrumental energy resolution. Assuming realistic experimental parameters corresponding to the currently available detector technology, we show that such a measurement is highly feasable.

  13. The S229L Colon Tumor-associated Variant of DNA Polymerase β Induces Cellular Transformation as a Result of Decreased Polymerization Efficiency*

    Nemec, Antonia A.; Murphy, Drew L.; Donigan, Katherine A.; Sweasy, Joann B.

    2014-01-01

    DNA polymerase β (Pol β) plays a key role in base excision repair (BER) by filling in small gaps that are generated after base adducts are excised from the DNA. Pol β is mutated in a large number of colorectal tumors, and these mutations may drive carcinogenesis. In the present study, we wished to determine whether the S229L somatic Pol β variant identified in a stage 3 colorectal tumor is a driver of carcinogenesis. We show that S229L does not possess any defects in binding to either DNA or nucleotides compared with the WT enzyme, but exhibits a significant loss of polymerization efficiency, largely due to an 8-fold decrease in the polymerization rate. S229L participates in BER, but due to its lower catalytic rate, does so more slowly than WT. Expression of S229L in mammalian cells induces the accumulation of BER intermediate substrates, chromosomal aberrations, and cellular transformation. Our results are consistent with the interpretation that S229L is a driver of carcinogenesis, likely as a consequence of its slow polymerization activity during BER in vivo. PMID:24668809

  14. Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E

    Crossley, Beate M.; Mock, Richard E.; Scott A. Callison; Hietala, Sharon K.

    2012-01-01

    In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV) was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A putative additional open-reading frame was identified between the nucleocapsid gene and 3'UTR. The ACoV was genetically most similar to the common human coronavirus (HCoV) 229E with 92.2% nucleotide identity over the entire genome. A comparison of spike ...

  15. Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E

    Hietala, Sharon K.; Mock, Richard E.; Scott A. Callison; Crossley, Beate M.

    2012-01-01

    In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV) was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A putative additional open-reading frame was identified between the nucleocapsid gene and 3'UTR. The ACoV was genetically most similar to the common human coronavirus (HCoV) 229E with 92.2% nucleotide identity over the entire genome. A comparison of s...

  16. Diversity and Evolutionary Histories of Human Coronaviruses NL63 and 229E Associated with Acute Upper Respiratory Tract Symptoms in Kuala Lumpur, Malaysia.

    Al-Khannaq, Maryam Nabiel; Ng, Kim Tien; Oong, Xiang Yong; Pang, Yong Kek; Takebe, Yutaka; Chook, Jack Bee; Hanafi, Nik Sherina; Kamarulzaman, Adeeba; Tee, Kok Keng

    2016-05-01

    The human alphacoronaviruses HCoV-NL63 and HCoV-229E are commonly associated with upper respiratory tract infections (URTI). Information on their molecular epidemiology and evolutionary dynamics in the tropical region of southeast Asia however is limited. Here, we analyzed the phylogenetic, temporal distribution, population history, and clinical manifestations among patients infected with HCoV-NL63 and HCoV-229E. Nasopharyngeal swabs were collected from 2,060 consenting adults presented with acute URTI symptoms in Kuala Lumpur, Malaysia, between 2012 and 2013. The presence of HCoV-NL63 and HCoV-229E was detected using multiplex polymerase chain reaction (PCR). The spike glycoprotein, nucleocapsid, and 1a genes were sequenced for phylogenetic reconstruction and Bayesian coalescent inference. A total of 68/2,060 (3.3%) subjects were positive for human alphacoronavirus; HCoV-NL63 and HCoV-229E were detected in 45 (2.2%) and 23 (1.1%) patients, respectively. A peak in the number of HCoV-NL63 infections was recorded between June and October 2012. Phylogenetic inference revealed that 62.8% of HCoV-NL63 infections belonged to genotype B, 37.2% was genotype C, while all HCoV-229E sequences were clustered within group 4. Molecular dating analysis indicated that the origin of HCoV-NL63 was dated to 1921, before it diverged into genotype A (1975), genotype B (1996), and genotype C (2003). The root of the HCoV-229E tree was dated to 1955, before it diverged into groups 1-4 between the 1970s and 1990s. The study described the seasonality, molecular diversity, and evolutionary dynamics of human alphacoronavirus infections in a tropical region. PMID:26928836

  17. Cloning, purification, crystallization and preliminary X-ray analysis of XC229, a conserved hypothetical protein from Xanthomonas campestris

    Chin, Ko-Hsin; Kuo, Wei-Tien [Institute of Biochemistry, National Chung-Hsing University, Taichung 40227,Taiwan (China); Chou, Chia-Cheng; Shr, Hui-Lin [Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei,Taiwan (China); Core Facility for Protein Crystallography, Academia Sinica, Nankang, Taipei,Taiwan (China); Lyu, Ping-Chiang [Department of Life Science, National Tsing Hua University, Hsin-Chu,Taiwan (China); Wang, Andrew H.-J. [Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei,Taiwan (China); Core Facility for Protein Crystallography, Academia Sinica, Nankang, Taipei,Taiwan (China); Chou, Shan-Ho, E-mail: shchou@nchu.edu.tw [Institute of Biochemistry, National Chung-Hsing University, Taichung 40227,Taiwan (China)

    2005-07-01

    A conserved hypothetical protein XC229 from X. campestris pv. campestris has been overexpressed in E. coli, purified and crystallized. A crystal of the purified recombinant protein diffracted to a resolution of 1.80 Å. Xanthomonas campestris pv. campestris is a Gram-negative yellow-pigmented pathogenic bacterium that causes black rot, one of the major worldwide diseases of cruciferous crops. Its genome contains approximately 4500 genes, roughly one third of which have no known structure and/or function. However, some of these unknown genes are highly conserved among several different bacterial genuses. XC229 is one such protein containing 134 amino acids. It was overexpressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion method. The crystal diffracted to a resolution of at least 1.80 Å. It is cubic and belongs to space group I2{sub x}3, with unit-cell parameters a = b = c = 106.8 Å. It contains one or two molecules per asymmetric unit.

  18. Io-U dates of a coral formation from the last interglacial age on the Brazilian coast. Use of /sup 229/Th as a tracer

    Bernat, M. (O.R.S.T.O.M., Universite de Nice, 06 - (France)); Martin, L.; Bittencourt, A.; Vilas Boas, G. (Universidade Federal da Bahia, Salvador (Brazil))

    1983-01-24

    Four coral samples taken in a quarry near the town of Ilheux (Bahia State, Brazil) analysed by an ..cap alpha.. spectrometry method for /sup 230/Th and uranium isotopes (using /sup 229/Th and /sup 232/U as tracers) gave a mean age of 123,500 years. These first datings confirm the general stability of the atlantic coast since that time.

  19. 12 CFR 609.910 - Compliance with the Electronic Signatures in Global and National Commerce Act (Public Law 106-229...

    2010-01-01

    ... FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM ELECTRONIC COMMERCE General Rules § 609.910 Compliance with the Electronic Signatures in Global and National Commerce Act (Public Law 106-229) (E-SIGN). (a... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Compliance with the Electronic Signatures...

  20. Discovery of a ∼5 day characteristic timescale in the Kepler power spectrum of Zw 229–15

    We present time series analyses of the full Kepler data set of Zw 229–15. This Kepler light curve—with a baseline greater than 3 yr, composed of virtually continuous, evenly sampled 30 minute measurements—is unprecedented in its quality and precision. We utilize two methods of power spectral analysis to investigate the optical variability and search for evidence of a bend frequency associated with a characteristic optical variability timescale. Each method yields similar results. The first interpolates across data gaps to use the standard Fourier periodogram. The second, using the CARMA-based time-domain modeling technique of Kelly et al., does not need evenly sampled data. Both methods find excess power at high frequencies that may be due to Kepler instrumental effects. More importantly, both also show strong bends (Δα ∼ 2) at timescales of ∼5 days, a feature similar to those seen in the X-ray power spectral densities of active galactic nuclei (AGNs) but never before in the optical. This observed ∼5 day timescale may be associated with one of several physical processes potentially responsible for the variability. A plausible association could be made with light-crossing dynamical or thermal timescales depending on the assumed value of the accretion disk size and on unobserved disk parameters such as α and H/R. This timescale is not consistent with the viscous timescale, which would be years in a ∼107 M ☉ AGN such as Zw 229–15. However, there must be a second bend on long (≳ 1 yr) timescales and that feature could be associated with the viscous timescale.

  1. Discovery of a ∼5 day characteristic timescale in the Kepler power spectrum of Zw 229–15

    Edelson, R.; Smith, K. L.; Mushotzky, R. [Department of Astronomy, University of Maryland, College Park, MD 20742-2421 (United States); Vaughan, S. [X-Ray and Observational Astronomy Group, Department of Physics and Astronomy, University of Leicester, University Road, Leicester LE1 7RH (United Kingdom); Malkan, M. [Department of Physics and Astronomy, University of California, Los Angeles, CA 90095-1547 (United States); Kelly, B. C. [Department of Physics, Broida Hall, University of California, Santa Barbara, CA 93106-9530 (United States); Boyd, P. T., E-mail: redelson@astro.umd.edu [Astrophysics Science Division, NASA/GSFC, Code 660, Greenbelt, MD 20771 (United States)

    2014-11-01

    We present time series analyses of the full Kepler data set of Zw 229–15. This Kepler light curve—with a baseline greater than 3 yr, composed of virtually continuous, evenly sampled 30 minute measurements—is unprecedented in its quality and precision. We utilize two methods of power spectral analysis to investigate the optical variability and search for evidence of a bend frequency associated with a characteristic optical variability timescale. Each method yields similar results. The first interpolates across data gaps to use the standard Fourier periodogram. The second, using the CARMA-based time-domain modeling technique of Kelly et al., does not need evenly sampled data. Both methods find excess power at high frequencies that may be due to Kepler instrumental effects. More importantly, both also show strong bends (Δα ∼ 2) at timescales of ∼5 days, a feature similar to those seen in the X-ray power spectral densities of active galactic nuclei (AGNs) but never before in the optical. This observed ∼5 day timescale may be associated with one of several physical processes potentially responsible for the variability. A plausible association could be made with light-crossing dynamical or thermal timescales depending on the assumed value of the accretion disk size and on unobserved disk parameters such as α and H/R. This timescale is not consistent with the viscous timescale, which would be years in a ∼10{sup 7} M {sub ☉} AGN such as Zw 229–15. However, there must be a second bend on long (≳ 1 yr) timescales and that feature could be associated with the viscous timescale.

  2. Magnetic hyperfine structure of the ground-state doublet in highly charged ions 89+,87+229Th and the Bohr-Weisskopf effect

    Tkalya, E. V.; Nikolaev, A. V.

    2016-07-01

    Background: The search for new opportunities to investigate the low-energy level in the 229Th nucleus, which is nowadays intensively studied experimentally, has motivated us to theoretical studies of the magnetic hyperfine (MHF) structure of the 5 /2+ (0.0 eV) ground state and the low-lying 3 /2+ (7.8 eV) isomeric state in highly charged 89+229Th and 87+229Th ions. Purpose: The aim is to calculate, with the maximal precision presently achievable, the energy of levels of the hyperfine structure of the 229Th ground-state doublet in highly charged ions and the probability of radiative transitions between these levels. Methods: The distribution of the nuclear magnetization (the Bohr-Weisskopf effect) is accounted for in the framework of the collective nuclear model with Nilsson model wave functions for the unpaired neutron. Numerical calculations using precise atomic density functional theory methods, with full account of the electron self-consistent field, have been performed for the electron structure inside and outside the nuclear region. Results: The deviations of the MHF structure for the ground and isomeric states from their values in a model of a pointlike nuclear magnetic dipole are calculated. The influence of the mixing of the states with the same quantum number F on the energy of sublevels is studied. Taking into account the mixing of states, the probabilities of the transitions between the components of the MHF structure are calculated. Conclusions: Our findings are relevant for experiments with highly ionized 229Th ions in a storage ring at an accelerator facility.

  3. Analysis of curative effect of gamma knife radiosurgery on 229 cases of acoustic neuromas%伽玛刀治疗听神经瘤229例疗效分析

    粱恩顺; 佘永传

    2012-01-01

    Objective To evaluate the effect of the gamma Knife radiosurgery on acoustic neuromas. Methods 229 patients with acoustic neuromas were treated with OUR Rotating Gamma System, and the postoperative condition was observed. Result Follow-up ranged from 6 to 60 months in the group,tumor size reduced in 98 patients,remained unchanged in 115 and increased in 16. Functional hearing was reduced in 38 patients and preserved in 130 who had useful hearing prior to gamma knife treatment. 54 patients developed new facial paralysis and 11 developed trigeminal injury. Conclusion Gamma -knife radiosurgery achieves high tumor control rate for acoustic ncuromas with preservation of functional hearing, minimal facial and trigeminal injury. It provides an optional treatment for patients with small to medium size acoustic neuromas, and an important adjuvant therapy for treating residual and recurrent tumors.%[目的]评价伽玛刀治疗听神经瘤的疗效.[方法]采用OUR旋转式伽玛刀治疗229例听神经瘤患者,观察术后病情变化.[结果]本组伽玛刀治疗病例随访6~60个月,其中肿瘤缩小98例,肿瘤体积不变115例,肿瘤增大16例,治疗前存在有用听力病例中38例听力下降;130例患者有用听力得到保留;54例出现患侧面瘫;11例出现三叉神经功能部分受损.[结论]伽玛刀对听神经瘤有较高的肿瘤控制率,并能保留有用听力,对面神经、三又神经损伤小,是小至中等大小听神经瘤可供选择的治疗[方法],及术后残余和复发肿瘤的重要辅助治疗手段.

  4. A new assay for invasion of HeLa 229 cells by Bordetella pertussis: effects of inhibitors, phenotypic modulation, and genetic alterations.

    Lee, C. K.; Roberts, A. L.; Finn, T M; Knapp, S; Mekalanos, J J

    1990-01-01

    Invasion and intracellular survival of Bordetella pertussis in HeLa 229 cells was studied by a new assay that utilizes polymyxin B instead of gentamicin to rapidly kill extracellular organisms. Invasion measured by this assay was time and temperature dependent and was inhibited by the microfilament drug cytochalasin D. The invasion process was also dependent on a functional vir locus (also known as bvg), the positive regulator of virulence gene expression in B. pertussis. Four spontaneous Vir...

  5. The effect of HIV infection on the incidence and severity of circular external fixator pin track sepsis: a retrospective comparative study of 229 patients

    Ferreira, Nando; Marais, Leonard Charles

    2014-01-01

    Pin track sepsis is a common complication of circular external fixation. HIV status has been implicated as an independent risk factor for the development of pin track infection and has been cited as a reason not to attempt complex limb reconstruction in HIV-positive patients. This retrospective review of patients treated with circular external fixators looked at the incidence of pin track sepsis in HIV-positive, HIV-negative and patients whose HIV status was unknown. The records of 229 patien...

  6. Probing the effect of the non-active-site mutation Y229W in New Delhi metallo-β-lactamase-1 by site-directed mutagenesis, kinetic studies, and molecular dynamics simulations.

    Jiao Chen

    Full Text Available New Delhi metallo-β-lactamase-1 (NDM-1 has attracted extensive attention for its high catalytic activities of hydrolyzing almost all β-lactam antibiotics. NDM-1 shows relatively higher similarity to subclass B1 metallo-β-lactamases (MβLs, but its residue at position 229 is identical to that of B2/B3 MβLs, which is a Tyr instead of a B1-MβL-conserved Trp. To elucidate the possible role of Y229 in the bioactivity of NDM-1, we performed mutagenesis study and molecular dynamics (MD simulations. Although residue Y229 is spatially distant from the active site and not contacting directly with the substrate or zinc ions, the Y229W mutant was found to have higher kcat and Km values than those of wild-type NDM-1, resulting in 1 ∼ 7 fold increases in k(cat /K(m values against tested antibiotics. In addition, our MD simulations illustrated the enhanced flexibility of Loop 2 upon Y229W mutation, which could increase the kinetics of both substrate entrance (kon and product egress (koff. The enhanced flexibility of Loop 2 might allow the enzyme to adjust the geometry of its active site to accommodate substrates with different structures, broadening its substrate spectrum. This study indicated the possible role of the residue at position 229 in the evolution of NDM-1.

  7. K2-29 b/WASP-152 b: An Aligned and Inflated Hot Jupiter in a Young Visual Binary

    Santerne, A.; Hébrard, G.; Lillo-Box, J.; Armstrong, D. J.; Barros, S. C. C.; Demangeon, O.; Barrado, D.; Debackere, A.; Deleuil, M.; Delgado Mena, E.; Montalto, M.; Pollacco, D.; Osborn, H. P.; Sousa, S. G.; Abe, L.; Adibekyan, V.; Almenara, J.-M.; André, P.; Arlic, G.; Barthe, G.; Bendjoya, P.; Behrend, R.; Boisse, I.; Bouchy, F.; Boussier, H.; Bretton, M.; Brown, D. J. A.; Carry, B.; Cailleau, A.; Conseil, E.; Coulon, G.; Courcol, B.; Dauchet, B.; Dalouzy, J.-C.; Deldem, M.; Desormières, O.; Dubreuil, P.; Fehrenbach, J.-M.; Ferratfiat, S.; Girelli, R.; Gregorio, J.; Jaecques, S.; Kugel, F.; Kirk, J.; Labrevoir, O.; Lachurié, J.-C.; Lam, K. W. F.; Le Guen, P.; Martinez, P.; Maurin, L. P. A.; McCormac, J.; Pioppa, J.-B.; Quadri, U.; Rajpurohit, A.; Rey, J.; Rivet, J.-P.; Roy, R.; Santos, N. C.; Signoret, F.; Strabla, L.; Suarez, O.; Toublanc, D.; Tsantaki, M.; Vienney, J.-M.; Wilson, P. A.; Bachschmidt, M.; Colas, F.; Gerteis, O.; Louis, P.; Mario, J.-C.; Marlot, C.; Montier, J.; Perroud, V.; Pic, V.; Romeuf, D.; Ubaud, S.; Verilhac, D.

    2016-06-01

    In the present paper we report the discovery of a new hot Jupiter, K2-29 b, first detected by the Super-WASP observatory and then by the K2 space mission during its campaign 4. The planet has a period of 3.25 days, a mass of 0.73 ± 0.04 M ♃, and a radius of 1.19 ± 0.02 R ♃. The host star is a relatively bright (V = 12.5) G7 dwarf with a nearby K5V companion. Based on stellar rotation and the abundance of lithium, we find that the system might be as young as ~450 Myr. The observation of the Rossiter–McLaughlin effect shows that the planet is aligned with respect to the stellar spin. Given the deep transit (20 mmag), the magnitude of the star and the presence of a nearby stellar companion, the planet is a good target for both space- and ground-based transmission spectroscopy, in particular in the near-infrared where both stars are relatively bright.

  8. Computational simulations of the effects of the G229D KCNQ1 mutation on human atrial fibrillation.

    Zulfa, Indana; Shim, Eun Bo; Song, Kwang-Soup; Lim, Ki Moo

    2016-09-01

    Atrial fibrillation (AF) is related to mutations at the genetic level. This includes mutations in genes that encode KCNQ1, a subunit of the I Ks channel. Here, we investigate the mechanism of gain-of-function in I Ks towards the occurrence of AF. We used the Courtemanche-Ramirez-Nattel (CRN) human atrial cell model (Am J Physiol Heart Circ Physiol 275:H301-H321, 1998) and applied the modification proposed by Hasegawa et al. (Heart Rhythm 11:67-75, 2014) to fit the behavior of I Ks due to the G229D mutation in KCNQ1 under a heterozygous mutant form. This was incorporated into two-(2D) and three-dimensional (3D) tissue models, where the mutation sustained a reentrant wave. However, under the wild-type condition, the reentrant wave terminated before the end of our simulations (in 2D, the spiral wave terminated before 10 s, while in 3D, the spiral wave terminated before 13 s). Sustained reentry under the mutation conditions also resulted in a spiral wave breakup in the 3D model, which was sustained until the end of the simulation (20 s), indicating AF. PMID:26922794

  9. Discovery of a ~5 day characteristic timescale in the Kepler power spectrum of Zw 229-15

    Edelson, Rick; Malkan, Matt; Kelly, Brandon; Smith, Krista; Boyd, Padi; Mushotzky, Richard

    2014-01-01

    We present time series analyses of the full Kepler dataset of Zw 229-15. This Kepler light curve --- with a baseline greater than three years, composed of virtually continuous, evenly sampled 30-minute measurements --- is unprecedented in its quality and precision. We utilize two methods of power spectral analysis to investigate the optical variability and search for evidence of a bend frequency associated with a characteristic optical variability timescale. Each method yields similar results. The first interpolates across data gaps to use the standard Fourier periodogram. The second, using the CARMA-based time-domain modeling technique of Kelly et al. (2014), does not need evenly-sampled data. Both methods find excess power at high frequencies that may be due to Kepler instrumental effects. More importantly both also show strong bends ({\\Delta}{\\alpha} ~ 2) at timescales of ~5 days, a feature similar to those seen in the X-ray PSDs of AGN but never before in the optical. This observed ~5 day timescale may be...

  10. Investigation of HIV Infection and Living Condition of 229 HIV Related Died Male's Widows%229名HIV故亡者女性遗属HIV感染情况及生活现状调查

    林赟; 杨佳; 罗志; 刘汶骏; 薛皓铭; 杨丽华; 朵林

    2016-01-01

    目的通过调查了解HIV故亡者女性遗属HIV感染现状及目前的生活状况,为下一步服务提供依据。方法横断面研究,回顾性调查,滚雪球抽样方法,云南省芒市、陇川、蒙自3县HIV故亡者女性遗属为调查对象,问卷收集基本信息、高危行为、生活现状及血样检测结果,SPSS17.0进行数据分析。结果共调查229人,汉族、农民和待业或无业为主;HIV检测阳性率61.1%;41.05%的调查对象曾经注射毒品;HIV检测结果为阳性和阴性的女性遗属在丈夫去世后单身时间、月收入有统计学差异,经济来源、受歧视程度、情绪消极程度无统计学差异。结论 HIV故亡者女性遗属吸毒人员较多,面临严峻的HIV感染风险,多无固定经济来源,社会歧视和自身消极情绪明显,需要社会各部门共同关注。%Objective Based on research the status quo and requirements of subsistence among HIV related died widows, to provide them further and targeted help. Methods Cross-section study and snowball sampling, retrospective investigation chose HIV related died widows distribute in Mangshi, Longchuan and Mengzi 3 counties in Yunnan to be the investigated object. Use questionnaire to collected demography, HIV related high risk behaviors, living condition and result of blood test. Meanwhile, use SPSS17.0 to analyze the data. Results Investigated 229 people, 41.05%respondents injected drug before. Most respondents are Han people, farmer and waiting job or unemployed. The HIV positive rate is 61.14%. there is statistic difference in single living time and salary per month between positive and negative HIV widows. However, no statistic difference among source of finance, the degree of discriminate and negative degree. Conclusion Most respondents are drug users themselves, they face high risk of HIV infection, social discrimination and their own negative emotions. they have no fixed income and need more concern from

  11. Quantifying UV-B flux over the Late Triassic Carnian Pluvial Extinction Event (c. 233-229 Ma).

    Miller, Charlotte; Fraser, Wesley; Jardine, Phil; Kürschner, Wolfram

    2015-04-01

    The geological record contains numerous episodes of global environmental change associated with pronounced transient perturbations to the global carbon cycle, some of which are closely linked with ocean acidification and mass extinction. Here, we focus on the Late Triassic mass extinction during the Carnian Pluvial Event (CPE) which occurred c. 233-229 million-years-ago (Ma). The CPE extinction remains one of the least studied and most controversial biotic crises due primarily to the lack of well-dated sedimentary successions. The CPE interval features a -4 o δ13C excursion, which is interpreted as a massive atmospheric injection of 13C-depleted carbon from the Wrangellia Flood Basalts. The associated increase in atmospheric pCO2 may then have accelerated the hydrological cycle, resulting in increased weathering and enhanced siliciclastic delivery to shallow carbonate basins. Volcanic activity is known to significantly alter the amount of incoming solar UV-B radiation via dimming processes, the destruction of ozone and increased cloud formation via the addition of cloud condensation nuclei to the atmosphere. To reconstruct variations in UV-B flux we have measured the abundance of phenolic components (UV-B absorbing compounds) contained within the cell wall of Ovalipollis pollen grains across the CPE, from samples taken from the Lunz region (Austria). These phenolic components are part of the defensive system of plants, where the abundance of phenolics increases with elevated UV-B flux. Our preliminary data indicate i) that the highest abundance of phenolics occur in the latter stages of the CPE, ii) the abundance of phenolics are highly variable throughout the CPE, and iii) the abundance of phenolics broadly increase towards the end of the Late Triassic. Here we will discuss the significance of the obtained data in terms of palaeoclimatic variability and the impact of volcanism during the Carnian Pluvial Event.

  12. No-mesh inguinal hernia repair with continuous absorbable sutures: A dream or reality? (a study of 229 patients

    Desarda Mohan

    2008-01-01

    Full Text Available Background/Aim: The author has published results from two series based on his new technique of inguinal hernia repair. Interrupted sutures with a nonabsorbable material were used for repairs in both theses series. The author now describes the results of repairs done with continuous absorbable sutures. Materials and Methods: This is a prospective study of 229 patients having 256 hernias operated from December 2003 to December 2006. An undetached strip of the external oblique aponeurosis was sutured between the inguinal ligament and the muscle arch to form the new posterior wall. Continuous sutures were taken with absorbable suture material (Monofilament Polydioxanone Violet. Data of hospital stay, complications, ambulation, recurrences, and pain were recorded. Follow-up was done until June 2007. Results: A total of 224 (97.8% patients were ambulatory within 6-8 h (mean: 6.42 h and they attained free ambulation within 18-24 h (mean: 19.26 h. A total of 222 (96.4% patients returned to work within 6-14 days (mean: 8.62 days and 209 (91.26% patients had one-night stays in the hospital. A total of 216 (94.3% patients had mild pain for 2 days. There were four minor complications, but no recurrence or incidence of chronic groin pain. Patients were followed up for a mean period of 24.28 months (range: 6-42 months. Conclusions: The results of this study correlate well with the author′s previous publications. Continuous suturing saves operative time and one packet of suture material. The dream of every surgeon to give recurrence-free inguinal hernia repair without leaving any foreign body inside the patient may well become a reality in future.

  13. Resonance ionization spectroscopy of thorium isotopestowards a laser spectroscopic identification of the low-lying 7.6 eV isomer of 229Th

    Raeder, S.; Sonnenschein, V.; Gottwald, T; Moore, I. D.; Reponen, M.; Rothe, S.; Trautmann, N; Wendt, K

    2011-01-01

    Abstract In-source resonance ionization spectroscopy was used to identify an efficient and selective three step excitation/ionization scheme of thorium, suitable for titanium:sapphire (Ti:sa) lasers. The measurements were carried out in preparation of laser spectroscopic investigations for an identification of the low-lying 229 m Th isomer predicted at 7.6 ? 0.5 eV above the nuclear ground state. Using a sample of 232 Th, a multitude of optical transitions leading to over 20 previously unk...

  14. Optical/Near-IR Polarization Survey of Sh 2-29: Magnetic Fields, Dense Cloud Fragmentations and Anomalous Dust Grain Sizes

    Santos, Fábio P.; Franco, Gabriel A. P.; Roman-Lopes, Alexandre; Reis, Wilson; Román-Zúñiga, Carlos G.

    2013-01-01

    Sh 2-29 is a conspicuous star-forming region marked by the presence of massive embedded stars as well as several notable interstellar structures. In this research, our goals were to determine the role of magnetic fields and to study the size distribution of interstellar dust particles within this turbulent environment. We have used a set of optical and near-infrared polarimetric data obtained at OPD/LNA (Brazil) and CTIO (Chile), correlated with extinction maps, 2MASS data and images from DSS...

  15. In vitro activity of nonoxynol 9 on HeLa 229 cells and primary monkey cervical epithelial cells infected with Chlamydia trachomatis.

    Patton, D L; Wang, S. K.; Kuo, C C

    1992-01-01

    Nonoxynol 9 (non-9) is the active ingredient in a wide variety of vaginal contraceptive preparations. The manufacturer recommendation for optimal contraceptive practice is repeated application every 6 h. We studied the in vitro activity of non-9 against Chlamydia trachomatis (E/UW-5/Cx) and its toxicity against HeLa 229 cells and monkey cervical epithelial cells. With a contact time of 6 h, non-9 was toxic to HeLa cells at concentrations of 50 micrograms/ml or greater and to monkey cervical c...

  16. Correction to the paper “a simple model to determine the interrelation between the integral characteristics of hall thrusters” [Plasma Physics Reports 40, 229 (2014)

    Shumilin, V. P. [All-Russian Electrotechnical Institute (Russian Federation); Shumilin, A. V.; Shumilin, N. V., E-mail: vladimirshumilin@yahoo.com [Moscow Institute of Electronics and Mathematics (Russian Federation)

    2015-11-15

    The paper is devoted to comparison of experimental data with theoretical predictions concerning the dependence of the current of accelerated ions on the operating voltage of a Hall thruster with an anode layer. The error made in the paper published by the authors in Plasma Phys. Rep. 40, 229 (2014) occurred because of a misprint in the Encyclopedia of Low-Temperature Plasma. In the present paper, this error is corrected. It is shown that the simple model proposed in the above-mentioned paper is in qualitative and quantitative agreement with experimental results.

  17. Correction to the paper “a simple model to determine the interrelation between the integral characteristics of hall thrusters” [Plasma Physics Reports 40, 229 (2014)

    The paper is devoted to comparison of experimental data with theoretical predictions concerning the dependence of the current of accelerated ions on the operating voltage of a Hall thruster with an anode layer. The error made in the paper published by the authors in Plasma Phys. Rep. 40, 229 (2014) occurred because of a misprint in the Encyclopedia of Low-Temperature Plasma. In the present paper, this error is corrected. It is shown that the simple model proposed in the above-mentioned paper is in qualitative and quantitative agreement with experimental results

  18. Construction of testing facilities and verifying tests of a 22.9 kV/630 A class superconducting fault current limiter

    We have constructed and completed the preparation for a long-term operation test of a superconducting fault current limiter (SFCL) in a Korea Electric Power Corporation (KEPCO) test grid. The SFCL with rating of 22.9 kV/630 A, 3-phases, has been connected to the 22.9 kV test grid equipped with reclosers and other protection devices in Gochang Power Testing Center of KEPCO. The main goals of the test are the verification of SFCL performance and protection coordination studies. A line-commutation type SFCL was fabricated and installed for this project, and the superconducting components were cooled by a cryo-cooler to 77 K in the sub-cooled liquid nitrogen pressurized by 3 bar of helium gas. The verification test includes un-manned - long-term operation with and without loads and fault tests. Since the test site is 170 km away from the laboratory, we will adopt the un-manned operation with real-time remote monitoring and controlling using high speed internet. For the fault tests, we will apply fault currents up to around 8 kArms to the SFCL using an artificial fault generator. The fault tests may allow us not only to confirm the current limiting capability of the SFCL, but also to adjust the SFCL - recloser coordination such as resetting over-current relay parameters. This paper describes the construction of the testing facilities and discusses the plans for the verification tests.

  19. Band structure and decay channels of thorium-229 low-lying isomeric state for ensemble of thorium atoms adsorbed on calcium fluoride

    The results are presented on the study of the electronic structure of thorium atoms adsorbed by the liquid atomic layer deposition from aqueous solution of thorium nitrate on the surface of CaF2. The chemical state of the atoms and the change of the band structure in the surface layers of Th/CaF2 system on CaF2 substrate were investigated by XPS and REELS techniques. It was found that REELS spectra for Th/CaF2 system include peaks in the region of low energy losses (3-7 eV) which are missing in the similar spectra for pure CaF2. It is concluded that the presence of the observed features in the REELS spectra is associated with the chemical state of thorium atoms and is caused by the presence of uncompensated chemical bonds at the Th/CaF2 interface, and, therefore, by the presence of unbound 6d- and 7s-electrons of thorium atoms. Assuming the equivalence of the electronic configuration of thorium-229 and thorium-232 atoms, an estimate was made on the time decay of the excited state of thorium-229 nuclei through the channel of the electron conversion. It was found that the relaxation time is about 40 μs for 6d-electrons, and about 1 μs for 7s-electrons. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  20. Resonance ionization spectroscopy of thorium isotopes-towards a laser spectroscopic identification of the low-lying 7.6 eV isomer of 229Th

    In-source resonance ionization spectroscopy was used to identify an efficient and selective three-step excitation/ionization scheme of thorium, suitable for titanium:sapphire (Ti:sa) lasers. The measurements were carried out in the preparation of laser spectroscopic investigations for an identification of the low-lying 229mTh isomer predicted at 7.6 ± 0.5 eV above the nuclear ground state. Using a sample of 232Th, a multitude of optical transitions leading to over 20 previously unknown intermediate states of even parity as well as numerous high-lying odd parity auto-ionizing (AI) states were identified. Level energies were determined with an accuracy of 0.06 cm-1 for intermediate and 0.15 cm-1 for AI states. Using different excitation pathways, an assignment of total angular momenta for several energy levels was possible. One particularly efficient ionization scheme of thorium, exhibiting saturation in all three optical transitions, was studied in detail. For all three levels in this scheme, the isotope shifts of the isotopes 228Th, 229Th and 230Th relative to 232Th were measured. An overall efficiency including ionization, transport and detection of 0.6% was determined, which was predominantly limited by the transmission of the mass spectrometer ion optics.

  1. Resonance ionization spectroscopy of thorium isotopes-towards a laser spectroscopic identification of the low-lying 7.6 eV isomer of {sup 229}Th

    Raeder, S; Sonnenschein, V; Gottwald, T; Rothe, S; Wendt, K [Institute of Physics, University of Mainz, Staudingerweg 7, 55128 Mainz (Germany); Moore, I D; Reponen, M [Department of Physics, University of Jyvaeskylae, Survontie 9, 40014 Jyvaeskylae (Finland); Trautmann, N, E-mail: raeder@uni-mainz.de, E-mail: volker.t.sonnenschein@jyu.fi [Institute of Nuclear Chemistry, University of Mainz, Fritz-Strassmann-Weg 2, 55128 Mainz (Germany)

    2011-08-28

    In-source resonance ionization spectroscopy was used to identify an efficient and selective three-step excitation/ionization scheme of thorium, suitable for titanium:sapphire (Ti:sa) lasers. The measurements were carried out in the preparation of laser spectroscopic investigations for an identification of the low-lying {sup 229m}Th isomer predicted at 7.6 {+-} 0.5 eV above the nuclear ground state. Using a sample of {sup 232}Th, a multitude of optical transitions leading to over 20 previously unknown intermediate states of even parity as well as numerous high-lying odd parity auto-ionizing (AI) states were identified. Level energies were determined with an accuracy of 0.06 cm{sup -1} for intermediate and 0.15 cm{sup -1} for AI states. Using different excitation pathways, an assignment of total angular momenta for several energy levels was possible. One particularly efficient ionization scheme of thorium, exhibiting saturation in all three optical transitions, was studied in detail. For all three levels in this scheme, the isotope shifts of the isotopes {sup 228}Th, {sup 229}Th and {sup 230}Th relative to {sup 232}Th were measured. An overall efficiency including ionization, transport and detection of 0.6% was determined, which was predominantly limited by the transmission of the mass spectrometer ion optics.

  2. Resonance ionization spectroscopy of thorium isotopes-towards a laser spectroscopic identification of the low-lying 7.6 eV isomer of 229Th

    Raeder, S.; Sonnenschein, V.; Gottwald, T.; Moore, I. D.; Reponen, M.; Rothe, S.; Trautmann, N.; Wendt, K.

    2011-08-01

    In-source resonance ionization spectroscopy was used to identify an efficient and selective three-step excitation/ionization scheme of thorium, suitable for titanium:sapphire (Ti:sa) lasers. The measurements were carried out in the preparation of laser spectroscopic investigations for an identification of the low-lying 229mTh isomer predicted at 7.6 ± 0.5 eV above the nuclear ground state. Using a sample of 232Th, a multitude of optical transitions leading to over 20 previously unknown intermediate states of even parity as well as numerous high-lying odd parity auto-ionizing (AI) states were identified. Level energies were determined with an accuracy of 0.06 cm-1 for intermediate and 0.15 cm-1 for AI states. Using different excitation pathways, an assignment of total angular momenta for several energy levels was possible. One particularly efficient ionization scheme of thorium, exhibiting saturation in all three optical transitions, was studied in detail. For all three levels in this scheme, the isotope shifts of the isotopes 228Th, 229Th and 230Th relative to 232Th were measured. An overall efficiency including ionization, transport and detection of 0.6% was determined, which was predominantly limited by the transmission of the mass spectrometer ion optics.

  3. MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol

    Substantial data indicate that the oncogene microRNA 21 (miR-21) is significantly elevated in glioblastoma multiforme (GBM) and regulates multiple genes associated with cancer cell proliferation, apoptosis, and invasiveness. Thus, miR-21 can theoretically become a target to enhance the chemotherapeutic effect in cancer therapy. So far, the effect of downregulating miR-21 to enhance the chemotherapeutic effect to taxol has not been studied in human GBM. Human glioblastoma U251 (PTEN-mutant) and LN229 (PTEN wild-type) cells were treated with taxol and the miR-21 inhibitor (in a poly (amidoamine) (PAMAM) dendrimer), alone or in combination. The 50% inhibitory concentration and cell viability were determined by the MTT assay. The mechanism between the miR-21 inhibitor and the anticancer drug taxol was analyzed using the Zheng-Jun Jin method. Annexin V/PI staining was performed, and apoptosis and the cell cycle were evaluated by flow cytometry analysis. Expression of miR-21 was investigated by RT-PCR, and western blotting was performed to evaluate malignancy related protein alteration. IC(50) values were dramatically decreased in cells treated with miR-21 inhibitor combine with taxol, to a greater extent than those treated with taxol alone. Furthermore, the miR-21 inhibitor significantly enhanced apoptosis in both U251 cells and LN229 cells, and cell invasiveness was obviously weakened. Interestingly, the above data suggested that in both the PTEN mutant and the wild-type GBM cells, miR-21 blockage increased the chemosensitivity to taxol. It is worth noting that the miR-21 inhibitor additively interacted with taxol on U251cells and synergistically on LN229 cells. Thus, the miR-21 inhibitor might interrupt the activity of EGFR pathways, independently of PTEN status. Meanwhile, the expression of STAT3 and p-STAT3 decreased to relatively low levels after miR-21 inhibitor and taxol treatment. The data strongly suggested that a regulatory loop between miR-21 and STAT3 might

  4. User's guide to program RCN. [Set of 3 FORTRAN IV programs, RCN29, HFMOD7, and RCN229, for SCF calculations of radial wave functions; for CDC 7600 computer

    Cowan, R. D.; Rajnak, K.; Renard, P.

    1976-06-01

    This is a set of three Fortran IV programs, RCN29, HFMOD7, and RCN229, based on the Herman--Skillman and Charlotte Froese Fischer programs, with extensive modifications and additions. The programs compute self-consistent-field radial wave functions and the various radial integrals involved in the computation of atomic energy levels and spectra.

  5. Magnetic hyperfine structure of the ground-state doublet in highly charged ions $^{229}$Th$^{89+,87+}$ and the Bohr-Weisskopf effect

    Tkalya, E V

    2016-01-01

    The magnetic hyperfine (MHF) structure of the $5/2^+$(0.0 eV) ground state and the low-lying $3/2^+$(7.8 eV) isomeric state of the $^{229}$Th nucleus in highly charged ions Th$^{89+}$ and Th$^{87+}$ is calculated. The distribution of the nuclear magnetization (the Bohr-Weisskopf effect) is accounted for in the framework of the collective nuclear model with the wave functions of the Nilsson model for the unpaired neutron. The deviations of the MHF structure for the ground and isomeric states from their values in the model of point-like nuclear magnetic dipole are calculated. The influence of the mixing of the states with the same quantum number $F$ on the energy of sublevels is studied. Taking into account the mixing of states, the probabilities of the transitions between the components of MHF structure are found.

  6. Band structure and decay channels of thorium-229 low-lying isomeric state for ensemble of thorium atoms adsorbed on calcium fluoride

    Borisyuk, Petr V.; Vasilyev, Oleg S.; Krasavin, Andrey V.; Troyan, Victor I. [National Research Nuclear University ' ' MEPhI' ' (Moscow Engineering Physics Institute), Kashirskoye shosse 31, 115409 Moscow (Russian Federation); Lebedinskii, Yury Yu. [National Research Nuclear University ' ' MEPhI' ' (Moscow Engineering Physics Institute), Kashirskoye shosse 31, 115409 Moscow (Russian Federation); Moscow Institute of Physics and Technology (State University), Institutskiy per. 9, 141700 Dolgoprudny, Moscow region (Russian Federation); Tkalya, Eugene V. [Skobeltsyn Institute of Nuclear Physics, Lomonosov Moscow State University, Leninskie gory, 119991 Moscow (Russian Federation); Nuclear Safety Institute of Russian Academy of Science, Bol' shaya Tulskaya 52, 115191 Moscow (Russian Federation)

    2015-12-15

    The results are presented on the study of the electronic structure of thorium atoms adsorbed by the liquid atomic layer deposition from aqueous solution of thorium nitrate on the surface of CaF{sub 2}. The chemical state of the atoms and the change of the band structure in the surface layers of Th/CaF{sub 2} system on CaF{sub 2} substrate were investigated by XPS and REELS techniques. It was found that REELS spectra for Th/CaF{sub 2} system include peaks in the region of low energy losses (3-7 eV) which are missing in the similar spectra for pure CaF{sub 2}. It is concluded that the presence of the observed features in the REELS spectra is associated with the chemical state of thorium atoms and is caused by the presence of uncompensated chemical bonds at the Th/CaF{sub 2} interface, and, therefore, by the presence of unbound 6d- and 7s-electrons of thorium atoms. Assuming the equivalence of the electronic configuration of thorium-229 and thorium-232 atoms, an estimate was made on the time decay of the excited state of thorium-229 nuclei through the channel of the electron conversion. It was found that the relaxation time is about 40 μs for 6d-electrons, and about 1 μs for 7s-electrons. (copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  7. Assessment of contralateral neck failure in 229 cases of carcinoma of the tonsillar region treated with techniques designed to spare contralateral parotid function

    Purpose/Objective: Radiation-induced xerostomia is a frequent cause of morbidity in head and neck cancer patients. To minimize this complication unilateral techniques (UT) designed to treat the primary tumor and ipsilateral neck have been used for many years in selected cases at our institution. Although such techniques exclude the contralateral parotid from the high dose target volume, they also leave the contralateral neck nodes untreated. The purpose of the study was to evaluate the risk of failure in the opposite neck. Materials and Methods: We identified 229 patients treated with UT from a series of 641 cases with carcinoma of the tonsillar region treated with curative intent between 1970 and 1991. Detailed documentation of the tumor, the radiation dosimetry, the sites of failure, and outcome including local, regional, and distant failure, and late complications, were performed. Actuarial 5-year plots were used to calculate local control, regional control, and survival rates. Results: Median age was 61 years (74 females/155 males); median follow-up 8 years (range 6 months to 21 years). AJCC (1992) T categories were T1:73, T2:120, T3:30, T4:6. The N category distribution was: N0:136, N1:53, N2a:29, N2b:8, and N3:8 cases. Base of tongue and palate were involved in 49 and 82 cases respectively. Irradiation techniques consisted of ipsilateral wedge pairs with Cobalt of 6MV photons in 210 cases (92%), while the remainder were electrons with or without photons. Customized compensators were used in the majority of cases in addition to the use of wedge filters. 75% received 50 Gy in 4 weeks, 10% received 60 Gy in 6 weeks, while the remainder received other doses intended to be curative. A radioactive implant was also used in 20 patients. The 5-year actuarial rates were as follows: overall local control: 76%, regional node control: 80%; cause specific survival: 80%. A total of 7 patients manifested regional disease in the opposite neck (crude rate of 3% or 7 of 229

  8. Lymphocytosis and Lymphopenia Induced by Imported Infectious Diseases: A Controlled Cross-Sectional Study of 17,229 Diseased German Travelers Returning from the Tropics and Subtropics.

    Herbinger, Karl-Heinz; Hanus, Ingrid; Beissner, Marcus; Berens-Riha, Nicole; Kroidl, Inge; von Sonnenburg, Frank; Löscher, Thomas; Hoelscher, Michael; Nothdurft, Hans Dieter; Schunk, Mirjam

    2016-06-01

    The present controlled cross-sectional study aimed to assess relative and absolute lymphocytosis and lymphopenia induced by imported infectious diseases (IDs) seen among patients consulting the Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (1999-2014) after being in the tropics and subtropics. The analysis investigated data sets from 17,229 diseased German travelers returning from Latin America (3,238), Africa (5,467), and Asia (8,524), and from 1,774 healthy controls who had not recently traveled. Among the cases, the proportion of those with relative lymphopenia (10.5%) and absolute lymphopenia (8.0%) was significantly higher than among controls (3.2% and 3.6%, respectively), whereas relative lymphocytosis was significantly lower among cases (6.1%) than among controls (8.0%). The study identified IDs with significantly larger proportions of relative lymphocytosis (cytomegalovirus [CMV] infection [56%], infectious mononucleosis [51%], and dengue fever [11%]); absolute lymphocytosis (infectious mononucleosis [70%] and CMV infection [63%]); relative lymphopenia (streptococcal pharyngitis [56%], malaria [34%], Campylobacter infection [19%], salmonellosis [18%], and shigellosis [17%]); and of absolute lymphopenia (human immunodeficiency virus infection [53%], malaria [45%], dengue fever [40%], salmonellosis [16%], and Campylobacter infection [11%]). This study demonstrates that relative and absolute lymphocytosis and lymphopenia are useful laboratory findings for travelers returning from the tropics and subtropics, as they are typically caused by imported viral, bacterial, and protozoan IDs. PMID:27068397

  9. Basic design of 22.9 kV/630 A resistive superconducting fault current limiting coil using YBCO coated conductor

    Based on active developing of YBCO coated conductor (CC), various applications of the conductor have been developed recently. HTS systems offer tremendous advantages. Of them, since YBCO material has a high index number and specifications such as thickness and material of the stabilizer of the conductor can be controlled, CC has many advantages for applying to superconducting fault current limiter (SFCL). In general, coated conductor has a thick metal layer as a stabilizer above superconducting layer such as YBCO. Since SFCL plays a role of limiting fault current using high resistivity when a fault occurs, it is important for the design of SFCL to choose and design the stabilizer. In this paper, the design parameters for SFCL have been found. For optimal design, specifications of CC and reached temperature during the fault as well as winding structure are investigated by experiments. From this investigation, safe electric field intensity was 40-56 V/m under the condition of temperature limit of 300-400 K. Considering the electric field intensity and the number of stacks, total required length of coated conductor was estimated. Consequently, required length of YBCO CC already commercialized with stainless steel stabilizer is between 5.66 and 7.92 km for three-phase distribution class SFCL rated on 22.9 kV/630 A. In addition, a possible design using expected wire was also conducted

  10. Resonance ionization spectroscopy of thorium isotopes-towards a laser spectroscopic identification of the low-lying 7.6 eV isomer of (229)Th

    Raeder, S; Wendt, K; Sonnenschein, V; Trautmann, N; Rothe, S; Reponen, M; Gottwald, T

    2011-01-01

    In-source resonance ionization spectroscopy was used to identify an efficient and selective three-step excitation/ionization scheme of thorium, suitable for titanium: sapphire (Ti:sa) lasers. The measurements were carried out in the preparation of laser spectroscopic investigations for an identification of the low-lying (229m)Th isomer predicted at 7.6 +/- 0.5 eV above the nuclear ground state. Using a sample of (232)Th, a multitude of optical transitions leading to over 20 previously unknown intermediate states of even parity as well as numerous high-lying odd parity auto-ionizing (AI) states were identified. Level energies were determined with an accuracy of 0.06 cm(-1) for intermediate and 0.15 cm(-1) for AI states. Using different excitation pathways, an assignment of total angular momenta for several energy levels was possible. One particularly efficient ionization scheme of thorium, exhibiting saturation in all three optical transitions, was studied in detail. For all three levels in this scheme, the is...

  11. Optical/Near-IR Polarization Survey of Sh 2-29: Magnetic Fields, Dense Cloud Fragmentations and Anomalous Dust Grain Sizes

    Santos, Fábio P; Roman-Lopes, Alexandre; Reis, Wilson; Román-Zúñiga, Carlos G

    2013-01-01

    Sh 2-29 is a conspicuous star-forming region marked by the presence of massive embedded stars as well as several notable interstellar structures. In this research, our goals were to determine the role of magnetic fields and to study the size distribution of interstellar dust particles within this turbulent environment. We have used a set of optical and near-infrared polarimetric data obtained at OPD/LNA (Brazil) and CTIO (Chile), correlated with extinction maps, 2MASS data and images from DSS and Spitzer. The region's most striking feature is a swept out interstellar cavity whose polarimetric maps indicate that magnetic field lines were dragged outwards, pilling up along its borders. This led to a higher magnetic strength value ($\\approx400\\,\\mu$G) and an abrupt increase in polarization degree, probably due to an enhancement in alignment efficiency. Furthermore, dense cloud fragmentations with peak $A_{V}$ between 20 and 37 mag were probably triggered by its expansion. The presence of $24\\,\\mu$m point-like so...

  12. Laser excitation of 8-eV electronic states in Th{sup +}. A first pillar of the electronic bridge toward excitation of the Th-229 nucleus

    Herrera-Sancho, Oscar-Andrey

    2012-11-23

    The possibility to realize a nuclear clock based on the optical magnetic dipole transition from the ground state to the low-energy isomeric state in the {sup 229}Th nucleus has motivated experiments and proposals toward highly accurate clocks with trapped ions and highly stable optical frequency standards with Th-doped solids. These systems hold great promise to open a field of research in the borderland between atomic and nuclear physics, which will enable highly sensitive tests of postulates from fundamental physics and also will allow us to coherently excite and control nuclear states, opening a wonderful and intriguing new field in physics. A major experimental obstacle that has to be overcome before any precision spectroscopy can be performed with this system is however the insufficient knowledge on the exact transition energy. The best experimental result so far is an indirect determination from {gamma}-spectroscopy with a relative uncertainty of about 6%. To facilitate the search for the nuclear transition within a wide uncertainty range around 8 eV, we investigate two-photon excitation in the dense electronic level structure of Th{sup +}, which enables the nuclear excitation via a resonantly enhanced inverse electronic bridge process. Experiments on one- and two-photon laser excitation of buffer gas cooled {sup 232}Th{sup +} ions in a radio-frequency ion trap are reported in this thesis. The strongest resonance line at 402 nm from the (6d{sup 2}7s)J=3/2 ground state to the (6d7s7p)J=5/2 state is driven as the first excitation step. Using nanosecond laser pulses in the 250-nm wavelength range for the second step of a two-photon excitation, we have observed seven previously unknown levels in the unexplored region of the electronic level structure around 8 eV. This investigation shows that the Th{sup +} ion seems to be well suited for the search of the isomer transition because both, theory and experimental results, agree on the density of strong transitions

  13. Optical/near-infrared polarization survey of Sh 2-29: Magnetic fields, dense cloud fragmentations, and anomalous dust grain sizes

    Sh 2-29 is a conspicuous star-forming region marked by the presence of massive embedded stars as well as several notable interstellar structures. In this research, our goals were to determine the role of magnetic fields and to study the size distribution of interstellar dust particles within this turbulent environment. We have used a set of optical and near-infrared polarimetric data obtained at OPD/LNA (Brazil) and CTIO (Chile), correlated with extinction maps, Two Micron All Sky Survey data, and images from the Digitized Sky Survey and Spitzer. The region's most striking feature is a swept out interstellar cavity whose polarimetric maps indicate that magnetic field lines were dragged outward, piling up along its borders. This led to a higher magnetic strength value (≈400 μG) and an abrupt increase in polarization degree, probably due to an enhancement in alignment efficiency. Furthermore, dense cloud fragmentations with peak AV between 20 and 37 mag were probably triggered by its expansion. The presence of 24 μm point-like sources indicates possible newborn stars inside this dense environment. A statistical analysis of the angular dispersion function revealed areas where field lines are aligned in a well-ordered pattern, seemingly due to compression effects from the H II region expansion. Finally, Serkowski function fits were used to study the ratio of the total-to-selective extinction, revealing a dual population of anomalous grain particle sizes. This trend suggests that both effects of coagulation and fragmentation of interstellar grains are present in the region.

  14. Optical/near-infrared polarization survey of Sh 2-29: Magnetic fields, dense cloud fragmentations, and anomalous dust grain sizes

    Santos, Fábio P.; Franco, Gabriel A. P.; Reis, Wilson [Departamento de Física, ICEx, UFMG, Caixa Postal 702, 30.123-970 Belo Horizote, MG (Brazil); Roman-Lopes, Alexandre [Departamento de Fisica-Universidad de La Serena, Cisternas 1200, La Serena (Chile); Román-Zúñiga, Carlos G., E-mail: fabiops@fisica.ufmg.br, E-mail: franco@fisica.ufmg.br, E-mail: wilsonr@fisica.ufmg.br, E-mail: roman@dfuls.cl, E-mail: croman@astrosen.unam.mx [Instituto de Astronomía-Universidad Nacional Autónoma de México, Unidad Académica en Ensenada, Ensenada BC 22860 (Mexico)

    2014-03-01

    Sh 2-29 is a conspicuous star-forming region marked by the presence of massive embedded stars as well as several notable interstellar structures. In this research, our goals were to determine the role of magnetic fields and to study the size distribution of interstellar dust particles within this turbulent environment. We have used a set of optical and near-infrared polarimetric data obtained at OPD/LNA (Brazil) and CTIO (Chile), correlated with extinction maps, Two Micron All Sky Survey data, and images from the Digitized Sky Survey and Spitzer. The region's most striking feature is a swept out interstellar cavity whose polarimetric maps indicate that magnetic field lines were dragged outward, piling up along its borders. This led to a higher magnetic strength value (≈400 μG) and an abrupt increase in polarization degree, probably due to an enhancement in alignment efficiency. Furthermore, dense cloud fragmentations with peak A{sub V} between 20 and 37 mag were probably triggered by its expansion. The presence of 24 μm point-like sources indicates possible newborn stars inside this dense environment. A statistical analysis of the angular dispersion function revealed areas where field lines are aligned in a well-ordered pattern, seemingly due to compression effects from the H II region expansion. Finally, Serkowski function fits were used to study the ratio of the total-to-selective extinction, revealing a dual population of anomalous grain particle sizes. This trend suggests that both effects of coagulation and fragmentation of interstellar grains are present in the region.

  15. The effect of lance geometry and carbon coating of silicon lances on propidium iodide uptake in lance array nanoinjection of HeLa 229 cells

    Sessions, John W.; Lindstrom, Dallin L.; Hanks, Brad W.; Hope, Sandra; Jensen, Brian D.

    2016-04-01

    Connecting technology to biologic discovery is a core focus of non-viral gene therapy biotechnologies. One approach that leverages both the physical and electrical function of microelectromechanical systems (MEMS) in cellular engineering is a technology previously described as lance array nanoinjection (LAN). In brief, LAN consists of a silicon chip measuring 2 cm by 2 cm that has been etched to contain an array of 10 μm tall, solid lances that are spaced every 10 μm in a grid pattern. This array of lances is used to physically penetrate hundreds of thousands of cells simultaneously and to then electrically deliver molecular loads into cells. In this present work, two variables related to the microfabrication of the silicon lances, namely lance geometry and coating, are investigated. The purpose of both experimental variables is to assess these parameters’ effect on propidium iodide (PI), a cell membrane impermeable dye, uptake to injected HeLa 229 cells. For the lance geometry experimentation, three different microfabricated lance geometries were used which include a flat/narrow (FN, 1 μm diameter), flat/wide (FW, 2-2.5 μm diameter), and pointed (P, 1 μm diameter) lance geometries. From these tests, it was shown that the FN lances had a slightly better cell viability rate of 91.73% and that the P lances had the best PI uptake rate of 75.08%. For the lance coating experimentation, two different lances were fabricated, both silicon etched lances with some being carbon coated (CC) in a  <100 nm layer of carbon and the other lances being non-coated (Si). Results from this experiment showed no significant difference between lance types at three different nanoinjection protocols (0V, +1.5V DC, and  +5V Pulsed) for both cell viability and PI uptake rates. One exception to this is the comparison of CC/5V Pul and Si/5V Pul samples, where the CC/5V Pul samples had a cell viability rate 5% higher. Both outcomes were unexpected and reveal how to better

  16. The effect of lance geometry and carbon coating of silicon lances on propidium iodide uptake in lance array nanoinjection of HeLa 229 cells

    Connecting technology to biologic discovery is a core focus of non-viral gene therapy biotechnologies. One approach that leverages both the physical and electrical function of microelectromechanical systems (MEMS) in cellular engineering is a technology previously described as lance array nanoinjection (LAN). In brief, LAN consists of a silicon chip measuring 2 cm by 2 cm that has been etched to contain an array of 10 μm tall, solid lances that are spaced every 10 μm in a grid pattern. This array of lances is used to physically penetrate hundreds of thousands of cells simultaneously and to then electrically deliver molecular loads into cells. In this present work, two variables related to the microfabrication of the silicon lances, namely lance geometry and coating, are investigated. The purpose of both experimental variables is to assess these parameters’ effect on propidium iodide (PI), a cell membrane impermeable dye, uptake to injected HeLa 229 cells. For the lance geometry experimentation, three different microfabricated lance geometries were used which include a flat/narrow (FN, 1 μm diameter), flat/wide (FW, 2–2.5 μm diameter), and pointed (P, 1 μm diameter) lance geometries. From these tests, it was shown that the FN lances had a slightly better cell viability rate of 91.73% and that the P lances had the best PI uptake rate of 75.08%. For the lance coating experimentation, two different lances were fabricated, both silicon etched lances with some being carbon coated (CC) in a  <100 nm layer of carbon and the other lances being non-coated (Si). Results from this experiment showed no significant difference between lance types at three different nanoinjection protocols (0V, +1.5V DC, and  +5V Pulsed) for both cell viability and PI uptake rates. One exception to this is the comparison of CC/5V Pul and Si/5V Pul samples, where the CC/5V Pul samples had a cell viability rate 5% higher. Both outcomes were unexpected and reveal how to better

  17. Photodissociation of methyl iodide at 229.4 nm: A determination of the fragment recoil anisotropy using energy-selective electron impact ionization and time-of-flight mass spectrometry

    Energy-selective electron impact ionization of laser-produced photofragments together with time-of-flight mass spectrometry is a general and sensitive means of studying primary photodissociation processes. Low-energy electrons ionize photofragments without the production of background fragment ions from dissociative ionization of the parent molecules, and the time-of-flight mass spectral peak shapes provide direct information on the photofragment recoil anisotropy. In the first application of this combination of techniques, we have studied the photodissociation of methyl iodide at 229.4 nm, the short-wavelength end of the A band, in order to assess the contribution of transitions to the 1Q1 state to the absorption profile. The results presented here show that I(2P1/sub //2) is the primary iodine--atom product and that the transition is largely parallel [β = (1.6 +- 0.1) for I(2P1/sub //2)] at 229.4 nm. These data together with previous photofragmentation results suggest that excitation to the 3Q0 state dominates the entire A band absorption profile

  18. System for recovery of daughter isotopes from a source material

    Tranter, Troy J [Idaho Falls, ID; Todd, Terry A [Aberdeen, ID; Lewis, Leroy C [Idaho Falls, ID; Henscheid, Joseph P [Idaho Falls, ID

    2009-08-04

    A method of separating isotopes from a mixture containing at least two isotopes in a solution is disclosed. A first isotope is precipitated and is collected from the solution. A daughter isotope is generated and collected from the first isotope. The invention includes a method of producing an actinium-225/bismuth-213 product from a material containing thorium-229 and thorium-232. A solution is formed containing nitric acid and the material containing thorium-229 and thorium-232, and iodate is added to form a thorium iodate precipitate. A supernatant is separated from the thorium iodate precipitate and a second volume of nitric acid is added to the thorium iodate precipitate. The thorium iodate precipitate is stored and a decay product comprising actinium-225 and bismuth-213 is generated in the second volume of nitric acid, which is then separated from the thorium iodate precipitate, filtered, and treated using at least one chromatographic procedure. A system for producing an actinium-225/bismuth-213 product is also disclosed.

  19. Viscosity of {xCO2 + (1 − x)CH4} with x = 0.5174 for temperatures between (229 and 348) K and pressures between (1 and 32) MPa

    Highlights: • New viscosity data for CO2 + CH4 are reported for a wide range of (T,p). • The new measurements are consistent with and extend literature viscosity data. • The new data deviate systematically by up to 16% from two extended corresponding states models. • A molecular dynamics corresponding states model reproduces the data within 4.2%. - Abstract: A vibrating wire instrument, in which the wire was clamped at both ends, was used to measure the viscosity of {xCO2 + (1 − x)CH4} with x = 0.5174 with a combined uncertainty of 0.24 μPa · s (a relative uncertainty of about 0.8 %) at temperatures T between (229 and 348) K and pressures p from (1 to 32) MPa. The corresponding mass density ρ, estimated with the GERG-2008 equation of state, varied from (20 to 600) kg · m−3. The measured viscosities were consistent within combined uncertainties with data obtained previously for this system using entirely different experimental techniques. The new data were compared with three corresponding states-type models frequently used for predicting mixture viscosities: the Extended Corresponding States (ECS) model implemented in REFPROP 9.1; the SUPERTRAPP model implemented in MultiFlash 4.4; and a corresponding states model derived from molecular dynamics simulations of Lennard Jones fluids. The measured viscosities deviated systematically from the predictions of both the ECS and SUPERTRAPP models with a maximum relative deviations of 11 % at (229 K, 600 kg · m−3) and −16 % at (258 K, 470 kg · m−3), respectively. In contrast, the molecular dynamics based corresponding states model, which is predictive for mixtures in that it does not contain any binary interaction parameters, reproduced the density and temperature dependence of the measured viscosities well, with relative deviations of less than 4.2 %

  20. Genes Expression in Response to Re-watering after Drought Stress in Shaan 229 and Characterization of Ethylene Receptor Genes (TaERS) in Wheat%陕229干旱复水诱导基因表达及小麦乙烯受体(TaERS)基因特征分析

    张宏; 陈锐; 黄林周; 胡银岗

    2012-01-01

    为了解小麦响应水分胁迫后复水条件下的基因表达特征,以小麦(Triticum aestivum L.)主栽品种陕229的3叶1心期幼苗为材料,采用消减杂交技术,构建了干旱复水条件下的SSH-cDNA表达文库.从消减文库中随机挑选59个插入片段大于400bp的阳性克隆测序,去除冗余序列和嵌合序列后,获得高质量EST序列32条(GenBank登录号为ES466767~ES466798).序列比对分析表明,小麦干旱后复水的基因表达与植物对其他非生物胁迫的响应具有交叉性;17条EST序列与已知编码蛋白的基因同源性较高,涉及植物的信号传导、能量代谢、转录调控等方面;其他序列为新的EST.以其中一个与乙烯受体基因(ERS)同源性较高的EST序列为基础,采用同源克隆及RACE技术从小麦中分离了4个乙烯受体基因的全长cDNA序列,长度分别为2090、2271、2216和1886bp.4个全长cDNA序列所编码氨基酸序列的同源性极高(99%以上),且均具有ERS典型的GAF、HisKA和HATPase-c跨膜结构,分别命名为TaERS1(HM347272),TaERS2(HM601437),TaERS3(HM601438)和TaERS4(HQ111523).植物ERS氨基酸序列多重比较表明,小麦与水稻的相似性最高(93%);TaERS基因的全长cDNA序列间比较共发现SNP位点23个.定量PCR表达分析显示,小麦TaERS家族基因参与了小麦植株响应水分胁迫和复水的调控机制.研究结果有助于进一步认识小麦干旱后复水的基因表达谱和小麦水分高效利用机制,探索小麦乙烯受体在水分高效利用中的作用.%To explore more genes for the improvement of drought-tolerance and water use efficiency in crops, the differential gene expression during re-watering after serious drought stress in common wheat (Triticumaestivum L.) was investigated by constructing SSH-cDNA library with the seedlings of Shaan 229 as materials. A total of 59 positive clones with insertions more than 400 bp were randomly picked from the library and sequenced. Then

  1. Radium-228 analysis of natural waters by Cherenkov counting of Actinium-228

    The activities of 228Ra in natural waters were determined by the Cherenkov counting of the daughter nuclide 228Ac. The radium was pre-concentrated on MnO2 and the radium purified via ion exchange and, after a 2-day period of incubation to allow for secular equilibrium between the parent-daughter 228Ra(228Ac), the daughter nuclide 228Ac was isolated by ion exchange according to the method of Nour et al. [2004. Radium-228 determination of natural waters via concentration on manganese dioxide and separation using Diphonix ion exchange resin. Appl. Radiat. Isot. 61, 1173-1178]. The Cherenkov photons produced by 228Ac were counted directly without the addition of any scintillation reagents. The optimum Cherenkov counting window, sample volume, and vial type were determined experimentally to achieve optimum Cherenkov photon detection efficiency and lowest background count rates. An optimum detection efficiency of 10.9±0.1% was measured for 228Ac by Cherenkov counting with a very low Cherenkov photon background of 0.317±0.013 cpm. The addition of sodium salicylate into the sample counting vial at a concentration of 0.1 g/mL yielded a more than 3-fold increase in the Cherenkov detection efficiency of 228Ac to 38%. Tests of the Cherenkov counting technique were conducted with several water standards of known activity and the results obtained compared closely with a conventional liquid scintillation counting technique. The advantages and disadvantages of Cherenkov counting compared to liquid scintillation counting methods are discussed. Advantages include much lower Cherenkov background count rates and consequently lower minimal detectable activities for 228Ra and no need for expensive environmentally unfriendly liquid scintillation cocktails. The disadvantages of the Cherenkov counting method include the need to measure 228Ac Cherenkov photon detection efficiency and optimum Cherenkov counting volume, which are not at all required when liquid scintillation analysis is used

  2. Linear free energy relationship applied to trivalent cations with lanthanum and actinium oxide and hydroxide structure

    Linear free energy relationships for trivalent cations with crystalline M2O3 and, M(OH)3 phases of lanthanides and actinides were developed from known thermodynamic properties of the aqueous trivalent cations, modifying the Sverjensky and Molling equation. The linear free energy relationship for trivalent cations is as ΔGf,MvX0=aMvXΔGn,M3+0+bMvX+βMvXrM3+, where the coefficients aMvX, bMvX, and βMvX characterize a particular structural family of MvX, rM3+ is the ionic radius of M3+ cation, ΔGf,MvX0 is the standard Gibbs free energy of formation of MvX and ΔGn,M3+0 is the standard non-solvation free energy of the cation. The coefficients for the oxide family are: aMvX=0.2705, bMvX=-1984.75 (kJ/mol), and βMvX=197.24 (kJ/molnm). The coefficients for the hydroxide family are: aMvX=0.1587, bMvX=-1474.09 (kJ/mol), and βMvX=791.70 (kJ/molnm).

  3. Actinium: A RESTful Runtime Container for Scriptable Internet of Things Applications

    Kovatsch, Matthias; Lanter, Martin; Duquennoy, Simon

    2012-01-01

    Programming Internet of Things (IoT) applications is challenging because developers have to be knowledgeable in various technical domains, from low-power networking, over embedded operating systems, to distributed algorithms. Hence, it will be challenging to find enough experts to provide software for the vast number of expected devices, which must also be scalable and particularly safe due to the connection to the physical world. To remedy this situation, we propose an architecture that pr...

  4. Reflection asymmetry in odd-A and odd-odd actinium nuclei

    Theoretical calculations and measurements indicate that octupole correlations are at a maximum in the ground states of the odd-proton nuclei Ac and Pa. It has been expected that odd-odd nuclei should have even larger amount of octupole-octupole correlations. We have recently made measurements on the structure of 224Ac. Although spin and parity assignments could not be made, two bands starting at 354.1 and 360.0 keV have properties characteristic of reflection asymmetric shape. These two bands have very similar rotational constants and also similar alpha decay rates, which suggest similarity between the wavefunctions of these bands. These signatures provide evidence for octupole correlations in these nuclides

  5. Bestimmung der Ionisationsenergie von Actinium und Ultraspurenanalyse von Plutonium mit resonanter Ionisationsmassenspektrometrie (RIMS)

    Waldek, Achim Marcus

    2001-01-01

    ZusammenfassungDie Resonanzionisationsmassenspektrometrie (RIMS) verbindet hohe Elementselektivität mit guter Nachweiseffizienz. Aufgrund dieser Eigenschaften ist die Methode für Ultraspurenanalyse und Untersuchungen an seltenen oder schwer handhabbaren Elementen gut geeignet. Für RIMS werden neutrale Atome mit monochromatischem Laserlicht ein- oder mehrfach resonant auf energetisch hoch liegende Niveaus angeregt und anschließend durch einen weiteren Laserstrahl oder durch ein elektrisches Fe...

  6. Synthesis of chelating agents for actinium 225 complexation and its application in radioimmunotherapy

    Immunotherapy with radiolabeled antibodies should allow fairly specific targeting of certain cancers. However, iodine 131 may not be the best isotope for tumor therapy because of its limited specific activity, low beta-energy, relatively long half life and strong gamma emission. Another approach to improve therapeutic efficacy is the use of replacement isotopes with better physical properties. Chelator that can hold radio-metals with high stability under physiological conditions are essential to avoid excessive damage to non-target cells; Moreover, the development of new bifunctional chelating agents is essential for this purpose. Accordingly, our efforts have been directed, for several years, to the synthesis of original chelating agents likely to form stable complexes in vivo with the numerous potential candidates for such applications. Therefore, we have developed a new simple and efficient synthesis pathway of 2-(4-iso-thio-cyanate-benzyl)-1,4,7,10,13,16- hexa-aza-cyclo-hexadecane- 1,4,7,10,13,16-hexa-acetic acid, though functionalized on the cycle by a termination allowed coupling to an antibody or any other biological substance such as a hapten. (author)

  7. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    A technique of selenium purification from 232Th, 238U, 226,228Ra, 227Ac and 40K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  8. Purification of selenium from thorium, uranium, radium, actinium and potassium impurities for low background measurements

    Rakhimov, A.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz); Warot, G. [CEA-CNRS, Modane (France). Laboratoire Souterrain de Modane (LSM); Karaivanov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Institute for Nuclear Research and Nuclear Energy (INRNE), Sofia (Bulgaria); Kochetov, O.I.; Lebedev, N.A.; Filosofov, D.V. [Joint Institute for Nuclear Research (JINR), Dubna (Russian Federation); Mukhamedshina, N.M.; Sadikov, I.I. [Uzbek Academy of Sciences, Tashkent (Uzbekistan). Inst. of Nuclear Physics (INP AS RUz)

    2013-07-01

    A technique of selenium purification from {sup 232}Th, {sup 238}U, {sup 226,228}Ra, {sup 227}Ac and {sup 40}K was developed. This technique is simple to perform and employs a minimum number of highly pure reagents (bidistilled water, nitric acid). Operations carried out during purification (elution, evaporation) practically exclude losses of the target product (chemical yields of Se > 99%). A test purification of 100 g of selenium was carried out using this technique. The efficiency of this technique was confirmed by low background gamma spectrometry of the purified selenium sample. Distribution coefficients of Th, U, Ra and Ac on DOWEX 50W- x 8 cation-exchange resin at different concentrations of selenium and nitric acid were experimentally determinated. Instrumental neutron activation analysis of bidistilled water, deionized water and nitric acid was performed. (orig.)

  9. 49 CFR 229.129 - Locomotive horn.

    2010-10-01

    ... defectives equal to an AQL of 1% or less, as set forth in 7 CFR part 43. (2) Each locomotive built before... horn that was replaced and the mounting location and type of mounting are the same. (c) Testing of the..., such as barriers, hills, billboards, tractor trailers or other large vehicles, locomotives or rail...

  10. 49 CFR 229.5 - Definitions.

    2010-10-01

    ...% confidence limit means the noise level below which 99% of all noise level measurements must lie. Washing... sound pressure level in decibels measured on the A-weighted scale. Dead locomotive means— (1) A... excess of 110 dB(A) and/or a minimum sound level below 96 dB(A), as measured 100 feet forward of...

  11. 20 CFR 229.2 - Definitions.

    2010-04-01

    ... Retirement Act). Retirement age means age 65, with respect to an employee or spouse who attains age 62 before...), or surviving divorced spouse) after December 31, 1999, retirement age means the age provided for in...' Benefits RAILROAD RETIREMENT BOARD REGULATIONS UNDER THE RAILROAD RETIREMENT ACT SOCIAL SECURITY...

  12. 50 CFR 229.2 - Definitions.

    2010-10-01

    ... information indicating the frequency of incidental mortality and serious injury of marine mammals by a... the absence of reliable information indicating the frequency of incidental mortality and serious..., asymmetry in the shape of the body or body position, noticeable swelling or hemorrhage, laceration,...

  13. 47 CFR 22.229 - Designated entities.

    2010-10-01

    ... entrepreneur is an entity that, together with its controlling interests and affiliates, has average annual... entrepreneur, as defined in this section, or a consortium of entrepreneurs may use the bidding credit...

  14. QTL Information Table: 229 [Q-TARO

    Full Text Available ). Characterization of the main effects, epistatic effects and their environmental interactions of QTLs on the genetic basis of yield traits in rice. Theor Appl Genet 105, 248-257. ...

  15. 49 CFR 229.107 - Pressure gauge.

    2010-10-01

    ....107 Pressure gauge. (a) Each steam generator shall have an illuminated steam gauge that correctly... the allowed working pressure of the steam generator. (b) Each steam pressure gauge on a steam generator shall have a siphon that prevents steam from entering the gauge. The pipe connection...

  16. 49 CFR 229.113 - Warning notice.

    2010-10-01

    ....113 Warning notice. Whenever any steam generator has been shut down because of defects, a distinctive warning notice giving reasons for the shut-down shall be conspicuously attached near the steam generator starting controls until the necessary repairs have been made. The locomotive in which the steam...

  17. 22 CFR 229.450 - Athletics.

    2010-04-01

    ... include boxing, wrestling, rugby, ice hockey, football, basketball, and other sports the purpose or major... of each sex or unequal expenditures for male and female teams if a recipient operates or...

  18. 50 CFR 229.9 - Emergency regulations.

    2010-10-01

    ... than 180 days or until the end of the applicable commercial fishing season, whichever is earlier... having, or is likely to have, an immediate and significant adverse impact on a stock or species, the... address such adverse impact; (2) In the case of a stock or species for which a take reduction plan...

  19. 49 CFR 229.27 - Annual tests.

    2010-10-01

    ... conducting the test and that person's supervisor shall sign the form. (c) Each steam generator that is not... the previous 48 hours of locomotive operation, reveals a failure to record a regularly recurring data element or reveals that any required data element is not representative of the actual operations of...

  20. 22 CFR 229.235 - Statutory amendments.

    2010-04-01

    ... abortion. Medical procedures, benefits, services, and the use of facilities, necessary to save the life of a pregnant woman or to address complications related to an abortion are not subject to this section... legal abortion. Accordingly, subject to paragraph (d)(1) of this section, no person shall be...

  1. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy; Radium-Aufreinigung zur Herstellung von Actinium-225 am Zyklotron fuer die Alpha-Immuntherapie

    Marx, Sebastian Markus

    2014-09-23

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  2. Distribution of trace elements in land plants and botanical taxonomy with special reference to rare earth elements and actinium

    Distribution profiles of trace elements in land plants were studied by neutron activation analysis and radioactivity measurements without activation. Number of botanical samples analyzed were more than three thousand in which more than three hundred botanical species were included. New accumulator plants of Co, Cr, Zn, Cd, rare earth elements, Ac, U, etc., were found. Capabilities of accumulating trace elements can be related to the botanical taxonomy. Discussions are given from view points of inorganic chemistry as well as from botanical physiology

  3. Purification of radium-226 for the manufacturing of actinium-225 in a cyclotron for alpha-immunotherapy

    The thesis describes the development of methods for the purification of Ra-226. The objective was to obtain the radionuclide in the quality that is needed to be used as starting material in the manufacturing process for Ac-225 via proton-irradiated Ra-226. The radionuclide has been gained efficiently out of huge excesses of impurities. The high purity of the obtained radium affords its use as staring material in a pharmaceutical manufacturing process.

  4. Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody

    Schwartz, J; O' Donoghue, J A; Humm, J L [Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); Jaggi, J S [Bristol-Myers Squibb, Plainsboro, NJ (United States); Ruan, S; Larson, S M [Nuclear Medicine Service Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065 (United States); McDevitt, M; Scheinberg, D A, E-mail: schwarj1@mskcc.org [Molecular Pharmacology and Chemistry, Sloan-Kettering Institute, 1275 York Avenue, New York, NY 10065 (United States)

    2011-02-07

    Clinical therapeutic studies using {sup 225}Ac-labeled antibodies have begun. Of major concern is renal toxicity that may result from the three alpha-emitting progeny generated following the decay of {sup 225}Ac. The purpose of this study was to determine the amount of {sup 225}Ac and non-equilibrium progeny in the mouse kidney after the injection of {sup 225}Ac-huM195 antibody and examine the dosimetric consequences. Groups of mice were sacrificed at 24, 96 and 144 h after injection with {sup 225}Ac-huM195 antibody and kidneys excised. One kidney was used for gamma ray spectroscopic measurements by a high-purity germanium (HPGe) detector. The second kidney was used to generate frozen tissue sections which were examined by digital autoradiography (DAR). Two measurements were performed on each kidney specimen: (1) immediately post-resection and (2) after sufficient time for any non-equilibrium excess {sup 213}Bi to decay completely. Comparison of these measurements enabled estimation of the amount of excess {sup 213}Bi reaching the kidney ({gamma}-ray spectroscopy) and its sub-regional distribution (DAR). The average absorbed dose to whole kidney, determined by spectroscopy, was 0.77 (SD 0.21) Gy kBq{sup -1}, of which 0.46 (SD 0.16) Gy kBq{sup -1} (i.e. 60%) was due to non-equilibrium excess {sup 213}Bi. The relative contributions to renal cortex and medulla were determined by DAR. The estimated dose to the cortex from non-equilibrium excess {sup 213}Bi (0.31 (SD 0.11) Gy kBq{sup -1}) represented {approx}46% of the total. For the medulla the dose contribution from excess {sup 213}Bi (0.81 (SD 0.28) Gy kBq{sup -1}) was {approx}80% of the total. Based on these estimates, for human patients we project a kidney-absorbed dose of 0.28 Gy MBq{sup -1} following administration of {sup 225}Ac-huM195 with non-equilibrium excess {sup 213}Bi responsible for approximately 60% of the total. Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of {sup 225}Ac radioimmunotherapy.

  5. 基于FHQZn发光的新结构有机黄光器件%Novel Structure Yellow Organic Light-emitting Devices Based on (E)-2-(2-(9H-fluoren-2-yl)vinyl)Quinolato-Zinc as Emitter

    丁桂英; 姜文龙; 黄涛; 高永慧; 孟昭辉; 欧阳新华; 曾和平

    2009-01-01

    利用一种新型材料(E)-2-(2-(9H-fluoren-2-y1)vinyl)quinolato-Zinc(FHQZn)制备了一种新结构的黄光OLED,器件的结构为:indium-tin oxide(ITO)/4,4',4"-(N,-(2-naphthyl)-N-phenylamino}-triphenylamine(2T-NATA)(15 nm)/FHQZn(x nm)/4,4'-bis(2,2'-diphenylvinyl)-1,1'-biphenyl(DPVBi)(20nm)/2,2',2"-(1,3,5-phenylene)tris(1-phenyl-iH-benzimidazole-(TPBi):6%fac tris(2一phenylpyridine)iridium(Ir(ppy)3)(45 nm)/LiF(0.5 nm)/Al,FHQZn作空穴传输层和黄色发光层,DPVBi作空穴阻挡层,TPBi中掺杂Ir(ppy); 作电子传输层;研究了发光层FHQZn的厚度对该器件的发光性能的影响.当FHQZn厚度x=25时,得到了效率和亮度最大的黄光器件,最大电流效率为1.31 cd/A(at 13 V),最大亮度为5 705 cd/m2(at 14 V),此时色坐标为(0.4,0.551 6).

  6. 17 CFR 229.1111 - (Item 1111) Pool assets.

    2010-04-01

    ... legal or regulatory provisions (such as bankruptcy, consumer protection, predatory lending, privacy... receivables and student loans, the location of the asset is the underlying obligor's billing address. For... student loans). If material, provide information required by paragraph (b)(14) of this section...

  7. 17 CFR 229.407 - (Item 407) Corporate governance.

    2010-04-01

    ... company's annual report on Form 10-K (17 CFR 249.310) (or, for closed-end investment companies registered... CFR 270.30d-1) thereunder) for the last fiscal year for filing with the Commission. (ii) The name of... annual report pursuant to General Instruction G(3) to Form 10-K (17 CFR 249.310). 2. If a...

  8. 17 CFR 229.1101 - (Item 1101) Definitions.

    2010-04-01

    ...-backed securities the yield, average life, expected maturity, interest rate sensitivity, cash flow characteristics, total rate of return, option adjusted spread or other financial or statistical information relating to the class or classes under specified prepayment, interest rate, loss or other...

  9. 49 CFR 229.31 - Main reservoir tests.

    2010-10-01

    ... (b) of this section, except the requirement for a pneumatic or hydrostatic test before it is placed... tests provided for by paragraphs (a) and (b) of this section, but shall receive a hydrostatic test... shall be subjected to a pneumatic or hydrostatic pressure of at least 25 percent more than the...

  10. 50 CFR 229.20 - Issuance of permits.

    2010-10-01

    ... impact on such species or stock; (2) A recovery plan has been developed or is being developed for such... mammals from a species or stock designated as depleted because of its listing as an endangered species or threatened species under the Endangered Species Act of 1973 if the Assistant Administrator determines...